{"text_format":"3","workbook":"xls","n_sheets":3,"sheets":["Sheet1","Sheet2","Sheet3"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Sheet1","index":0,"n_rows":95,"n_cols":7,"rows_kept":95,"merged":[[3,3,3,4],[3,5,4,5],[3,6,4,6],[89,0,89,6]],"flags":["formulas_cached_only"]}
["Electronic supplementary material"]
["ESM Table 1"]
[]
[{"$nulls":3},"Average delta (Ct)",null,"Fold change","p value"]
["Well","Symbol","Gene Description","Insulin group","Control group"]
["A01","ACACA","Acetyl-Coenzyme A carboxylase alpha",2.261889,2.403778,1.1033,0.702925]
["A02","ACOX1","Acyl-Coenzyme A oxidase 1, palmitoyl",3.944722,3.853278,0.9386,0.775418]
["A03","ADRB3","Adrenergic, beta-3-, receptor",9.490222,9.373278,0.9221,0.840872]
["A04","AEBP1","AE binding protein 1",2.638722,2.399778,0.8474,0.386172]
["A05","AKT1","V-akt murine thymoma viral oncogene homolog 1",2.357222,2.336611,0.9858,0.912175]
["A06","AKT2","V-akt murine thymoma viral oncogene homolog 2",6.266889,5.996778,0.8293,0.499891]
["A07","AKT3","V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)",0.086556,"–0.208389",0.8151,0.493581]
["A08","ANG","Angiogenin, ribonuclease, RNase A family, 5",6.937722,6.244944,0.6187,0.062596]
["A09","ARAF","V-raf murine sarcoma 3611 viral oncogene homolog",4.712056,4.501944,0.8645,0.258196]
["A10","BCL2L1","BCL2-like 1",3.182056,3.138278,0.9701,0.903822]
["A11","BRAF","V-raf murine sarcoma viral oncogene homolog B1",5.654889,5.706778,1.0366,0.787321]
["A12","CAP1","CAP, adenylate cyclase-associated protein 1 (yeast)","–1.310778","–1.286056",1.0173,0.918145]
["B01","CBL","Cas-Br-M (murine) ecotropic retroviral transforming sequence",6.379222,6.334278,0.9693,0.785161]
["B02","CEBPA","CCAAT/enhancer binding protein (C/EBP), alpha",9.490222,9.432444,0.9607,0.922611]
["B03","CEBPB","CCAAT/enhancer binding protein (C/EBP), beta",2.010056,1.798944,0.8639,0.599005]
["B04","DOK1","Docking protein 1, 62kDa (downstream of tyrosine kinase 1)",4.539556,3.984611,0.6807,0.180031]
["B05","DOK2","Docking protein 2, 56kDa",9.330056,9.410444,1.0573,0.910012]
["B06","DOK3","Docking protein 3",6.779222,7.158778,1.3009,0.544326]
["B07","DUSP14","Dual specificity phosphatase 14",1.402556,1.222278,0.8825,0.581784]
["B08","EIF2B1","Eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa",2.314056,2.424778,1.0798,0.743741]
["B09","EIF4EBP1","Eukaryotic translation initiation factor 4E binding protein 1",2.165556,2.127278,0.9738,0.938869]
["B10","ERCC1","Excision repair cross-complementing rodent repair deficiency, complementation group 1",1.752556,1.497944,0.8382,0.281079]
["B11","FASN","Fatty acid synthase",0.982889,1.301278,1.2469,0.236985]
["B12","FBP1","Fructose-1,6-bisphosphatase 1",9.045556,9.212278,1.1225,0.748068]
["C01","FOS","V-fos FBJ murine osteosarcoma viral oncogene homolog",5.514556,4.817111,0.6167,0.290352]
["C02","FRAP1","FK506 binding protein 12-rapamycin associated protein 1",3.364889,3.277944,0.9415,0.745483]
["C03","FRS2","Fibroblast growth factor receptor substrate 2",5.871222,5.513278,0.7803,0.095007]
["C04","FRS3","Fibroblast growth factor receptor substrate 3",4.731722,4.670611,0.9585,0.850371]
["C05","G6PC","Glucose-6-phosphatase, catalytic subunit",9.490222,9.468611,0.9851,0.971117]
["C06","GAB1","GRB2-associated binding protein 1",3.495056,3.284278,0.8641,0.093499]
["C07","GCK","Glucokinase (hexokinase 4)",9.490222,9.468611,0.9851,0.971117]
["C08","GPD1","Glycerol-3-phosphate dehydrogenase 1 (soluble)",9.330389,9.026278,0.8099,0.635508]
["C09","GRB2","Growth factor receptor-bound protein 2",4.222056,4.076611,0.9041,0.395907]
["C10","GSK3A","Glycogen synthase kinase 3 alpha",2.080722,1.988944,0.9384,0.757117]
["C11","GSK3B","Glycogen synthase kinase 3 beta",3.416222,3.239944,0.885,0.455193]
["C12","HK2","Hexokinase 2",7.853556,7.941278,1.0627,0.801406]
["D01","HRAS","V-Ha-ras Harvey rat sarcoma viral oncogene homolog",4.919556,4.947944,1.0199,0.915368]
["D02","IGF1R","Insulin-like growth factor 1 receptor",7.507722,6.843444,0.631,0.027718]
["D03","IGF2","Insulin-like growth factor 2 (somatomedin A)",1.914556,1.611278,0.8104,0.639266]
["D04","IGFBP1","Insulin-like growth factor binding protein 1",9.294056,9.468611,1.1286,0.767013]
["D05","INS","Insulin",9.490222,9.468611,0.9851,0.971117]
["D06","INSL3","Insulin-like 3 (Leydig cell)",9.484722,9.468611,0.9889,0.978439]
["D07","INSR","Insulin receptor",7.793556,7.111444,0.6233,0.19262]
["D08","IRS1","Insulin receptor substrate 1",3.149389,3.083611,0.9554,0.822964]
["D09","IRS2","Insulin receptor substrate 2",6.024056,5.345778,0.6249,0.098243]
["D10","IRS4","Insulin receptor substrate 4",9.442722,9.285111,0.8965,0.790009]
["D11","JUN","Jun oncogene",1.943722,1.900111,0.9702,0.916007]
["D12","KRAS","V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog",2.047222,2.075944,1.0201,0.919655]
["E01","LDLR","Low density lipoprotein receptor (familial hypercholesterolemia)",5.588889,5.687611,1.0708,0.875975]
["E02","LEP","Leptin",8.723722,9.016278,1.2248,0.725123]
["E03","MAP2K1","Mitogen-activated protein kinase kinase 1",3.717722,3.622611,0.9362,0.74389]
["E04","MAPK1","Mitogen-activated protein kinase 1",0.375056,0.334778,0.9725,0.741644]
["E05","NCK1","NCK adaptor protein 1",2.080389,1.914444,0.8913,0.710595]
["E06","NOS2A","Nitric oxide synthase 2A (inducible, hepatocytes)",8.636222,8.877111,1.1817,0.789115]
["E07","NPY","Neuropeptide Y",9.336389,9.318778,0.9879,0.975491]
["E08","PCK2","Phosphoenolpyruvate carboxykinase 2 (mitochondrial)",1.995722,1.863611,0.9125,0.807683]
["E09","PDPK1","3-phosphoinositide dependent protein kinase-1",3.966556,3.748944,0.86,0.270982]
["E10","PIK3CA","Phosphoinositide-3-kinase, catalytic, alpha polypeptide",1.836889,1.580278,0.8371,0.551163]
["E11","PIK3R1","Phosphoinositide-3-kinase, regulatory subunit 1 (alpha)",2.446056,2.573778,1.0926,0.611761]
["E12","PIK3R2","Phosphoinositide-3-kinase, regulatory subunit 2 (beta)",3.472889,3.302944,0.8889,0.446894]
["F01","PKM2","Pyruvate kinase, muscle","–2.245778","–2.213556",1.0226,0.91838]
["F02","PPARG","Peroxisome proliferator-activated receptor gamma",7.444722,7.629778,1.1369,0.779792]
["F03","PPP1CA","Protein phosphatase 1, catalytic subunit, alpha isoform",1.217389,1.190278,0.9814,0.914261]
["F04","PRKCG","Protein kinase C, gamma",9.490222,9.468611,0.9851,0.971117]
["F05","PRKCI","Protein kinase C, iota",0.931556,0.797111,0.911,0.68172]
["F06","PRKCZ","Protein kinase C, zeta",4.165056,4.129278,0.9755,0.912902]
["F07","PRL","Prolactin",9.194222,9.468611,1.2095,0.716621]
["F08","PTPN1","Protein tyrosine phosphatase, non-receptor type 1",4.502722,4.254444,0.8419,0.523982]
["F09","PTPRF","Protein tyrosine phosphatase, receptor type, F",4.173389,4.154111,0.9867,0.978863]
["F10","RAF1","V-raf-1 murine leukemia viral oncogene homolog 1",3.559556,3.514444,0.9692,0.776774]
["F11","RETN","Resistin",9.419889,9.445778,1.0181,0.964361]
["F12","RPS6KA1","Ribosomal protein S6 kinase, 90kDa, polypeptide 1",9.490222,9.468611,0.9851,0.971117]
["G01","RRAS","Related RAS viral (r-ras) oncogene homolog",0.424722,0.352778,0.9514,0.702311]
["G02","RRAS2","Related RAS viral (r-ras) oncogene homolog 2",0.668056,0.535944,0.9125,0.566036]
["G03","SERPINE1","Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1","–2.165111","–2.054389",1.0798,0.877626]
["G04","SHC1","SHC (Src homology 2 domain containing) transforming protein 1","–0.433778","–0.346722",1.0622,0.814467]
["G05","SLC2A1","Solute carrier family 2 (facilitated glucose transporter), member 1",9.268722,9.468611,1.1486,0.736219]
["G06","SLC2A4","Solute carrier family 2 (facilitated glucose transporter), member 4 (GLUT4)",8.412889,8.782944,1.2924,0.402892]
["G07","SORBS1","Sorbin and SH3 domain containing 1",7.481222,8.443444,1.9483,0.022429]
["G08","SOS1","Son of sevenless homolog 1 (Drosophila)",0.440222,0.310278,0.9139,0.75991]
["G09","SREBF1","Sterol regulatory element binding transcription factor 1",6.020056,6.519111,1.4133,0.121763]
["G10","TG","Thyroglobulin",9.046722,8.951611,0.9362,0.846458]
["G11","UCP1","Uncoupling protein 1 (mitochondrial, proton carrier)",9.296222,9.253111,0.9706,0.937356]
["G12","VEGFA","Vascular endothelial growth factor A",1.025222,0.872944,0.8998,0.633425]
["Housekeeping genes"]
["H01","B2M","Beta-2-microglobulin","–0.447611","–0.420222",1.0192,0.922791]
["H02","HPRT1","Hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)",4.894889,4.880944,0.9904,0.893694]
["H03","RPL13A","Ribosomal protein L13a",0.952222,0.684944,0.8309,0.296757]
["H04","GAPDH","Glyceraldehyde-3-phosphate dehydrogenase",0.315389,0.457278,1.1033,0.603979]
["H05","ACTB","Actin, beta","–4.447278","–4.460722",0.9907,0.94891]

{"sheet":"Sheet2","index":1,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}

{"sheet":"Sheet3","index":2,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}