CompuSyn Report
Experiment Name:MDA-MB-231
Date: 10/1/2025
File Name:D:\Work\DR HEBA RAD\MDA-MB-231.cse
DescriptionCombination between Abemaciclib and 2.4.6.10 GY

Drug:Abemaciclib (Abe) [µM]
Drug:GY (GY) [Gy]
Drug Combo:Combination index (Comb) (Abe+GY)

Data for Drug: Abe [µM]
DoseEffect
1.56     0.19
3.12     0.22
6.25     0.226
12.5     0.297
25.0     0.505
50.0     0.719
6 data points entered.
X-int:1.36430
Y-int:-0.9090 +/- 0.14851
m:0.66626 +/- 0.13790
Dm:23.1367
r:0.92397
Data for Drug: GY [Gy]
DoseEffect
2.0     0.02
6.0     0.14
10.0     0.206
3 data points entered.
X-int:1.32006
Y-int:-2.1506 +/- 0.17609
m:1.62919 +/- 0.23419
Dm:20.8959
r:0.98983
Data for Non-Constant Combo: Comb (Abe+GY)
Dose AbeDose GYEffect
1.56     2.0     0.4
3.12     2.0     0.42
6.25     2.0     0.4
12.5     2.0     0.44
25.0     2.0     0.8
50.0     2.0     0.82
6 data points entered.
Dose-Effect Curve
Median-Effect Plot
CI Data for Non-Constant Combo: Comb (Abe+GY)
Dose AbeDose GYEffectCI
1.56     2.0     0.4     0.24667
3.12     2.0     0.42     0.33559
6.25     2.0     0.4     0.61921
12.5     2.0     0.44     0.88689
25.0     2.0     0.8     0.17577
50.0     2.0     0.82     0.25968
Combination Index Plot
DRI Data for Non-Constant Combo: Comb (Abe+GY)
FaDose AbeDose GYDRI AbeDRI GY
0.4     12.5893     16.2921     8.07007     8.14604     
0.42     14.2529     17.1404     4.56824     8.57018     
0.4     12.5893     16.2921     2.01429     8.14604     
0.44     16.1102     18.0208     1.28882     9.01042     
0.8     185.329     48.9335     7.41316     24.4667     
0.82     225.277     52.9998     4.50554     26.4999     
DRI Plot for Non-Constant Combo: Comb (Abe+GY)
Normalized Isobologram for Combo: Comb (Abe+GY)
Summary Table
Experiment Name:MDA-MB-231
Date: 10/1/2025
File Name:D:\Work\DR HEBA RAD\MDA-MB-231.cse
DescriptionCombination between Abemaciclib and 2.4.6.10 GY

Drug:Abemaciclib (Abe) [µM]
Drug:GY (GY) [Gy]
Drug Combo:Combination index (Comb) (Abe+GY)

Drug/ComboDmmr
Abe23.1367     0.66626     0.92397
GY20.8959     1.62919     0.98983
CI values at:
ComboED50ED75ED90ED95
Data for Fa = 0.5
Drug/Combo CI valueDose AbeDose GY
Abe23.1367
GY20.8959
Data for Fa = 0.75
Drug/Combo CI valueDose AbeDose GY
Abe120.343
GY41.0127
Data for Fa = 0.9
Drug/Combo CI valueDose AbeDose GY
Abe625.951
GY80.4963
Data for Fa = 0.95
Drug/Combo CI valueDose AbeDose GY
Abe1921.34
GY127.339
Data for Fa = 0.97
Drug/Combo CI valueDose AbeDose GY
Abe4267.39
GY176.476