CompuSyn Report
Experiment Name:MCF7 Combination
Date: 10.1.2025
File Name:D:\Work\DR HEBA RAD\combination MCF7.cse
DescriptionMCF7 Abe Cobination 2, 6, 10 Gy

Drug:Abemaciclib (Abe) [uM]
Drug:GY (Gy) [Gy]
Drug Combo:Abe+2 Gy (Abe2gy) (Abe+Gy)

Data for Drug: Abe [uM]
DoseEffect
1.56     0.27
3.12     0.32
6.25     0.36
12.5     0.4
25.0     0.42
50.0     0.46
6 data points entered.
X-int:1.94784
Y-int:-0.4521 +/- 0.01800
m:0.23213 +/- 0.01671
Dm:88.6821
r:0.98979
Data for Drug: Gy [Gy]
DoseEffect
2.0     0.01
6.0     0.073
10.0     0.108
3 data points entered.
X-int:1.53235
Y-int:-2.4443 +/- 0.18500
m:1.59514 +/- 0.24604
Dm:34.0679
r:0.98831
Data for Non-Constant Combo: Abe2gy (Abe+Gy)
Dose AbeDose GyEffect
1.56     2.0     0.32
3.12     2.0     0.38
6.25     2.0     0.396
12.5     2.0     0.4
25.0     2.0     0.48
50.0     2.0     0.51
6 data points entered.
Dose-Effect Curve
Median-Effect Plot
CI Data for Non-Constant Combo: Abe2gy (Abe+Gy)
Dose AbeDose GyEffectCI
1.56     2.0     0.32     0.54658
3.12     2.0     0.38     0.36968
6.25     2.0     0.396     0.51088
12.5     2.0     0.4     0.88417
25.0     2.0     0.48     0.45970
50.0     2.0     0.51     0.53181
Combination Index Plot
DRI Data for Non-Constant Combo: Abe2gy (Abe+Gy)
FaDose AbeDose GyDRI AbeDRI Gy
0.32     3.44816     21.2384     2.21036     10.6192     
0.38     10.7629     25.0646     3.44965     12.5323     
0.396     14.3882     26.1461     2.30212     13.0731     
0.4     15.4612     26.4212     1.23689     13.2106     
0.48     62.8177     32.4006     2.51271     16.2003     
0.51     105.362     34.9331     2.10723     17.4666     
DRI Plot for Non-Constant Combo: Abe2gy (Abe+Gy)
Normalized Isobologram for Combo: Abe2gy (Abe+Gy)
Summary Table
Experiment Name:MCF7 Combination
Date: 10.1.2025
File Name:D:\Work\DR HEBA RAD\combination MCF7.cse
DescriptionMCF7 Abe Cobination 2, 6, 10 Gy

Drug:Abemaciclib (Abe) [uM]
Drug:GY (Gy) [Gy]
Drug Combo:Abe+2 Gy (Abe2gy) (Abe+Gy)

Drug/ComboDmmr
Abe88.6821     0.23213     0.98979
Gy34.0679     1.59514     0.98831
CI values at:
ComboED50ED75ED90ED95
Data for Fa = 0.5
Drug/Combo CI valueDose AbeDose Gy
Abe88.6821
Gy34.0679
Data for Fa = 0.75
Drug/Combo CI valueDose AbeDose Gy
Abe10075.2
Gy67.8351
Data for Fa = 0.9
Drug/Combo CI valueDose AbeDose Gy
Abe1144647
Gy135.071
Data for Fa = 0.95
Drug/Combo CI valueDose AbeDose Gy
Abe2.862E7
Gy215.775
Data for Fa = 0.97
Drug/Combo CI valueDose AbeDose Gy
Abe2.827E8
Gy301.128