CompuSyn Report
Experiment Name:MDA-MB-231
Date: 10/1/2025
File Name:D:\Work\DR HEBA RAD\MDA-MB-231.cse
DescriptionCombination between Abemaciclib and 2.4.6.10 GY

Drug:Abemaciclib (Abe) [µM]
Drug:GY (GY) [Gy]
Drug Combo:Combination 10 GY (COMB10) (Abe+GY)

Data for Drug: Abe [µM]
DoseEffect
1.56     0.19
3.12     0.22
6.25     0.226
12.5     0.297
25.0     0.505
50.0     0.719
6 data points entered.
X-int:1.36430
Y-int:-0.9090 +/- 0.14851
m:0.66626 +/- 0.13790
Dm:23.1367
r:0.92397
Data for Drug: GY [Gy]
DoseEffect
2.0     0.02
6.0     0.14
10.0     0.206
3 data points entered.
X-int:1.32006
Y-int:-2.1506 +/- 0.17609
m:1.62919 +/- 0.23419
Dm:20.8959
r:0.98983
Data for Non-Constant Combo: COMB10 (Abe+GY)
Dose AbeDose GYEffect
1.56     10.0     0.48
3.12     10.0     0.49
6.25     10.0     0.55
12.5     10.0     0.56
25.0     10.0     0.7
50.0     10.0     0.8
6 data points entered.
Dose-Effect Curve
Median-Effect Plot
CI Data for Non-Constant Combo: COMB10 (Abe+GY)
Dose AbeDose GYEffectCI
1.56     10.0     0.48     0.57869
3.12     10.0     0.49     0.63366
6.25     10.0     0.55     0.62298
12.5     10.0     0.56     0.78891
25.0     10.0     0.7     0.58742
50.0     10.0     0.8     0.47415
Combination Index Plot
DRI Data for Non-Constant Combo: COMB10 (Abe+GY)
FaDose AbeDose GYDRI AbeDRI GY
0.48     20.5175     19.8941     13.1523     1.98941     
0.49     21.7883     20.3891     6.98343     2.03891     
0.55     31.2684     23.6349     5.00295     2.36349     
0.56     33.2277     24.2297     2.65821     2.42297     
0.7     82.5284     35.1500     3.30114     3.51500     
0.8     185.329     48.9335     3.70658     4.89335     
DRI Plot for Non-Constant Combo: COMB10 (Abe+GY)
Normalized Isobologram for Combo: COMB10 (Abe+GY)
Summary Table
Experiment Name:MDA-MB-231
Date: 10/1/2025
File Name:D:\Work\DR HEBA RAD\MDA-MB-231.cse
DescriptionCombination between Abemaciclib and 2.4.6.10 GY

Drug:Abemaciclib (Abe) [µM]
Drug:GY (GY) [Gy]
Drug Combo:Combination 10 GY (COMB10) (Abe+GY)

Drug/ComboDmmr
Abe23.1367     0.66626     0.92397
GY20.8959     1.62919     0.98983
CI values at:
ComboED50ED75ED90ED95
Data for Fa = 0.5
Drug/Combo CI valueDose AbeDose GY
Abe23.1367
GY20.8959
Data for Fa = 0.75
Drug/Combo CI valueDose AbeDose GY
Abe120.343
GY41.0127
Data for Fa = 0.9
Drug/Combo CI valueDose AbeDose GY
Abe625.951
GY80.4963
Data for Fa = 0.95
Drug/Combo CI valueDose AbeDose GY
Abe1921.34
GY127.339
Data for Fa = 0.97
Drug/Combo CI valueDose AbeDose GY
Abe4267.39
GY176.476