CompuSyn Report
Experiment Name:MCF7 Combination
Date: 10.1.2025
File Name:D:\Work\DR HEBA RAD\combination MCF7.cse
DescriptionMCF7 Abe Cobination 2, 6, 10 Gy

Drug:Abemaciclib (Abe) [uM]
Drug:GY (Gy) [Gy]
Drug Combo:Abe+10 (Abe10G) (Abe+Gy)

Data for Drug: Abe [uM]
DoseEffect
1.56     0.27
3.12     0.32
6.25     0.36
12.5     0.4
25.0     0.42
50.0     0.46
6 data points entered.
X-int:1.94784
Y-int:-0.4521 +/- 0.01800
m:0.23213 +/- 0.01671
Dm:88.6821
r:0.98979
Data for Drug: Gy [Gy]
DoseEffect
2.0     0.01
6.0     0.073
10.0     0.108
3 data points entered.
X-int:1.53235
Y-int:-2.4443 +/- 0.18500
m:1.59514 +/- 0.24604
Dm:34.0679
r:0.98831
Data for Non-Constant Combo: Abe10G (Abe+Gy)
Dose AbeDose GyEffect
1.56     10.0     0.4
3.12     10.0     0.46
6.25     10.0     0.52
12.5     10.0     0.54
25.0     10.0     0.56
50.0     10.0     0.61
6 data points entered.
Dose-Effect Curve
Median-Effect Plot
CI Data for Non-Constant Combo: Abe10G (Abe+Gy)
Dose AbeDose GyEffectCI
1.56     10.0     0.4     0.47938
3.12     10.0     0.46     0.39477
6.25     10.0     0.52     0.32909
12.5     10.0     0.54     0.33611
25.0     10.0     0.56     0.35209
50.0     10.0     0.61     0.30383
Combination Index Plot
DRI Data for Non-Constant Combo: Abe10G (Abe+Gy)
FaDose AbeDose GyDRI AbeDRI Gy
0.4     15.4612     26.4212     9.91101     2.64212     
0.46     44.4475     30.8099     14.2460     3.08099     
0.52     125.196     35.8210     20.0313     3.58210     
0.54     176.939     37.6704     14.1552     3.76704     
0.56     250.629     39.6282     10.0252     3.96282     
0.61     609.147     45.0953     12.1829     4.50953     
DRI Plot for Non-Constant Combo: Abe10G (Abe+Gy)
Normalized Isobologram for Combo: Abe10G (Abe+Gy)
Summary Table
Experiment Name:MCF7 Combination
Date: 10.1.2025
File Name:D:\Work\DR HEBA RAD\combination MCF7.cse
DescriptionMCF7 Abe Cobination 2, 6, 10 Gy

Drug:Abemaciclib (Abe) [uM]
Drug:GY (Gy) [Gy]
Drug Combo:Abe+10 (Abe10G) (Abe+Gy)

Drug/ComboDmmr
Abe88.6821     0.23213     0.98979
Gy34.0679     1.59514     0.98831
CI values at:
ComboED50ED75ED90ED95
Data for Fa = 0.5
Drug/Combo CI valueDose AbeDose Gy
Abe88.6821
Gy34.0679
Data for Fa = 0.75
Drug/Combo CI valueDose AbeDose Gy
Abe10075.2
Gy67.8351
Data for Fa = 0.9
Drug/Combo CI valueDose AbeDose Gy
Abe1144647
Gy135.071
Data for Fa = 0.95
Drug/Combo CI valueDose AbeDose Gy
Abe2.862E7
Gy215.775
Data for Fa = 0.97
Drug/Combo CI valueDose AbeDose Gy
Abe2.827E8
Gy301.128