category	subcategory	ID	Description	GeneRatio	BgRatio	RichFactor	FoldEnrichment	zScore	pvalue	p.adjust	qvalue	geneID	Count
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	37/211	203/8542	0.182266009852217	7.37875002918311	14.637726784179	2.31310043749467e-22	6.47668122498509e-20	3.60356699736012e-20	VEGFA/KDR/ITGA1/PRKCA/RHOA/PDGFRB/PDGFRA/ITGB1/SHC1/ITGB7/XIAP/FLNA/LAMA1/COL1A2/COL1A1/COL2A1/COL4A1/COL6A1/COL4A2/COL6A2/COL4A3/COL6A3/COL4A4/COL4A5/COL4A6/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/RAF1/BRAF/PDGFA/FLT1/HGF/BCL2	37
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	44/211	362/8542	0.121546961325967	4.92063575187871	12.1305683903792	3.029174220029e-19	4.2408439080406e-17	2.35956728718049e-17	VEGFA/KDR/NTRK1/NTRK2/ITGA1/CDK2/PRKCA/PDGFRB/PDGFRA/ITGB1/IKBKB/CHUK/ITGB7/CDKN1B/TP53/MDM2/IGF2/NR4A1/LAMA1/COL1A2/COL1A1/COL2A1/COL4A1/COL6A1/COL4A2/COL6A2/COL4A3/COL6A3/COL4A4/COL4A5/COL4A6/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/RAF1/PDGFA/FLT1/INS/HGF/BCL2L1/BCL2	44
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	24/211	93/8542	0.258064516129032	10.4473322122	14.5779020555062	1.76281524554362e-18	1.64529422917404e-16	9.15426864352476e-17	CDK2/SKP2/ITGB1/IKBKB/CHUK/XIAP/CDKN1B/TP53/LAMA1/COL4A1/COL4A2/COL4A3/COL4A4/COL4A5/COL4A6/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/BCL2L1/BCL2/PTGS2	24
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	22/211	89/8542	0.247191011235955	10.0071356302253	13.5932496346569	1.376071224656e-16	9.63249857259198e-15	5.35943529602862e-15	ITGA1/ITGB1/ITGB7/LAMA1/COL1A2/COL1A1/COL2A1/COL4A1/COL6A1/COL4A2/COL6A2/COL4A3/COL6A3/COL4A4/COL4A5/COL4A6/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3	22
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	38/211	333/8542	0.114114114114114	4.61972873347281	10.7225982791965	9.89477853468775e-16	5.54107597942514e-14	3.08300468028166e-14	VEGFA/ITGA1/CDK2/CCNA2/PDGFRB/ITGB1/IKBKB/CHUK/ITGB7/ATM/ATR/CDKN1B/TP53/MDM2/LAMA1/COL1A2/COL1A1/COL2A1/COL4A1/COL6A1/COL4A2/COL6A2/COL4A3/COL6A3/COL4A4/COL4A5/COL4A6/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/RAF1/HLA-A/TNF/PRKCZ/PTGS2	38
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	22/211	103/8542	0.213592233009709	8.64694243776745	12.4253308434356	3.84044751341254e-15	1.79220883959252e-13	9.97168828043957e-14	PRKCA/ITGB2/IL1R1/CXCL8/LAMA1/IL12B/COL1A2/COL1A1/COL3A1/COL4A1/COL4A2/COL4A3/COL4A4/COL4A5/COL4A6/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/TNF	22
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	21/211	101/8542	0.207920792079208	8.41734315611656	11.9332607342462	2.969967760565e-14	1.187987104226e-12	6.60985306110707e-13	VEGFA/MMP2/PRKCA/ICAM1/EGR1/PRKCD/CXCL8/CDKN1B/COL1A2/COL1A1/COL3A1/COL4A1/COL4A2/COL4A3/COL4A4/COL4A5/COL4A6/TGFBR1/TNF/PRKCZ/BCL2	21
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	21/211	105/8542	0.2	8.09668246445498	11.644022067226	6.74817288710953e-14	2.36186051048834e-12	1.31411787801607e-12	CPB2/COL1A2/COL1A1/COL2A1/COL3A1/COL4A1/COL5A1/COL6A1/COL11A1/COL18A1/COL27A1/COL4A2/COL5A2/COL6A2/COL11A2/COL4A3/COL6A3/COL4A4/COL4A5/COL4A6/CTRL	21
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	18/211	98/8542	0.183673469387755	7.43572879388722	10.1972644270496	2.0479651177466e-11	6.37144703298944e-10	3.54501564241518e-10	CDK2/PDGFRB/PDGFRA/MMP9/PLAU/IKBKB/CHUK/MMP3/CDKN1B/TP53/MDM2/RAF1/BRAF/PLAT/PDGFA/INS/AR/BCL2	18
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	26/211	232/8542	0.112068965517241	4.53693413956529	8.69195511345679	7.71877214492356e-11	2.1612562005786e-09	1.20250344994599e-09	TPM3/ITGA1/MYH9/ITGB1/ITGB7/LMNA/MYH7/LAMA1/COL1A2/COL1A1/COL3A1/COL4A1/COL5A1/COL6A1/COL11A1/COL27A1/COL4A2/COL5A2/COL6A2/COL11A2/COL4A3/COL6A3/COL4A4/COL4A5/COL4A6/PLEC	26
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	18/211	112/8542	0.160714285714286	6.50626269465132	9.33467436426598	2.08169652417763e-10	5.29886387972488e-09	2.94824005338076e-09	ITGB1/IKBKB/CHUK/HSPA1A/XIAP/LAMA1/IL12B/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/HSPA8/TNF/ALOX5/BCL2L1/BCL2	18
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	19/211	130/8542	0.146153846153846	5.91680641633248	8.98984440630331	3.47672472269286e-10	8.11235768628334e-09	4.51364262244336e-09	VEGFA/MMP2/MMP1/PRKCA/SHC1/MMP9/MMP13/COL1A2/COL1A1/COL3A1/COL4A1/COL4A2/COL4A3/COL4A4/COL4A5/COL4A6/RAF1/TGFBR1/PRKCZ	19
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	17/211	115/8542	0.147826086956522	5.98450443024933	8.56409410669093	2.57032623035968e-09	5.53608726539009e-08	3.08022900480351e-08	PRKCA/HTR3A/MAOA/MAOB/HTR3B/CYP2C9/CYP2C19/CYP2D6/HTR1A/HTR2A/RAF1/BRAF/ALOX5/PTGS1/ALOX15/PTGS2/SLC6A4	17
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	23/211	216/8542	0.106481481481481	4.31073371950149	7.84295901890433	2.84355353330953e-09	5.68710706661906e-08	3.16425505962264e-08	MMP1/PRKCA/RHOA/APOA1/ICAM1/MMP9/IKBKB/CHUK/CXCL8/MMP3/HSPA1A/HSPA5/CYP1A1/CYP2C9/TP53/ABCA1/IL12B/HSPA8/OLR1/TNF/PPP3CA/BCL2L1/BCL2	23
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	26/211	300/8542	0.0866666666666667	3.50856240126382	7.0390856935647	2.00203448986948e-08	3.73713104775636e-07	2.07930599649602e-07	VEGFA/KDR/NTRK1/NTRK2/PRKCA/PDGFRB/PDGFRA/IL1R1/IKBKB/CHUK/HSPA1A/TP53/FLNA/IGF2/NR4A1/RAF1/BRAF/HSPA8/TGFBR1/PDGFA/FLT1/INS/TNF/PPP3CA/HGF/MAPT	26
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	21/211	204/8542	0.102941176470588	4.16741009199888	7.28677661327461	2.64523156150517e-08	4.62915523263404e-07	2.57562020462345e-07	VEGFA/KDR/MMP2/PRKCA/RHOA/ITGB1/MMP9/ESR1/PLAU/PLAUR/TP53/FLNA/MDM2/IGF2/IL12B/COL1A2/COL1A1/RAF1/BRAF/TNF/HGF	21
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/211	41/8542	0.24390243902439	9.8740030054329	9.06407547331064	3.92653670870734e-08	6.46723693198857e-07	3.59831227794853e-07	VEGFA/MMP2/MMP1/MMP9/CXCL8/TP53/CDKN2A/MDM2/RAF1/BRAF	10
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	21/211	238/8542	0.0882352941176471	3.5720657931419	6.40433296739347	3.759910431858e-07	5.848749560668e-06	3.25419148488295e-06	VEGFA/KDR/NTRK1/NTRK2/PRKCA/RHOA/PDGFRB/PDGFRA/SHC1/PLA2G2A/IKBKB/CHUK/PLA2G5/PLA2G10/IGF2/RAF1/PDGFA/FLT1/INS/HGF/BCL2L1	21
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	8/211	30/8542	0.266666666666667	10.7955766192733	8.55306647045893	4.45080099982811e-07	6.55907515764142e-06	3.6494102380862e-06	PLA2G2A/PLA2G5/PLA2G10/CYP3A4/CYP1A2/CYP2C9/CYP2C19/ALOX15	8
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/211	80/8542	0.15	6.07251184834123	7.25401709098194	5.19232129924627e-07	7.26924981894478e-06	4.04454501204446e-06	VEGFA/KDR/PRKCA/PDGFRB/PDGFRA/SHC1/RAF1/BRAF/PDGFA/HGF/BCL2L1/BCL2	12
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	20/211	224/8542	0.0892857142857143	3.6145903859174	6.31052123389752	5.98994164611058e-07	7.98658886148078e-06	4.44366598307953e-06	CDK2/CCNA2/ITGAL/ICAM1/ITGB2/IL1R1/EGR1/IKBKB/CHUK/ATM/ATR/XIAP/TP53/CDKN2A/TGFBR1/NRP1/HLA-A/TNF/PPP3CA/BCL2L1	20
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	13/211	99/8542	0.131313131313131	5.31600363827852	6.87381795413544	8.38544959004998e-07	1.06723903873363e-05	5.93802171926984e-06	MMP2/SHC1/MMP9/ESR1/ESR2/CDKN1B/CYP2D6/TP53/CDKN2A/MDM2/RAF1/BRAF/BCL2	13
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	12/211	88/8542	0.136363636363636	5.52046531667385	6.78328988548459	1.48778918788059e-06	1.81122162002854e-05	1.00774736753468e-05	CPB2/ITGB2/MASP2/PLAU/PLAUR/F2/FGA/FGB/FGG/PLAT/F13A1/PLG	12
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	13/211	105/8542	0.123809523809524	5.01223200180546	6.58314898571993	1.66096382117209e-06	1.93779112470077e-05	1.07816949795381e-05	ICAM1/IL1R1/PRKCQ/PLAU/IKBKB/CHUK/ATM/CXCL8/XIAP/TNF/BCL2L1/BCL2/PTGS2	13
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/211	141/8542	0.106382978723404	4.30674599173137	6.30074525601088	1.85581816780411e-06	2.07851634794061e-05	1.15646774246319e-05	VEGFA/KDR/MMP2/RHOA/ICAM1/IL1R1/MMP9/IKBKB/CHUK/TP53/PLAT/PDGFA/TNF/PRKCZ/BCL2	15
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	11/211	77/8542	0.142857142857143	5.78334461746784	6.70981542366096	2.5761680350818e-06	2.77433480701117e-05	1.54361485502877e-05	SHC1/IKBKB/CHUK/CDKN1B/TP53/CDKN2A/MDM2/RAF1/BRAF/TGFBR1/BCL2L1	11
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	10/211	63/8542	0.158730158730159	6.42593846385316	6.87891340712847	2.7850996051275e-06	2.88825144235444e-05	1.6069970431145e-05	PLA2G2A/PLA2G5/PLA2G10/CYP2C9/CYP2C19/LTA4H/ALOX5/PTGS1/ALOX15/PTGS2	10
Human Diseases	Cancer: specific types	hsa05214	Glioma	10/211	76/8542	0.131578947368421	5.32676477924669	6.02945379230048	1.5723363988333e-05	0.00015723363988333	8.74833785817024e-05	PRKCA/PDGFRB/PDGFRA/SHC1/TP53/CDKN2A/MDM2/RAF1/BRAF/PDGFA	10
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	12/211	115/8542	0.104347826086957	4.22435606841129	5.53990656238077	2.48741602891401e-05	0.000226199883182011	0.000125855574101269	NR4A2/PDE4A/PDE4D/PDE4B/PRKCA/RHOA/EGR1/MMP13/MMP14/RAF1/BRAF/BCL2	12
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	13/211	134/8542	0.0970149253731343	3.92749522529532	5.43562220915279	2.50435584951513e-05	0.000226199883182011	0.000125855574101269	PRKCA/RHOA/MYH9/EDNRA/PRKCD/PRKCH/PRKCQ/PLA2G2A/PLA2G5/PLA2G10/RAF1/BRAF/NPR2	13
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	13/211	134/8542	0.0970149253731343	3.92749522529532	5.43562220915279	2.50435584951513e-05	0.000226199883182011	0.000125855574101269	PRKCA/SHC1/ITGAL/ICAM1/ITGB2/RAF1/BRAF/KLRK1/MICA/HLA-A/FCGR3A/TNF/PPP3CA	13
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	16/211	198/8542	0.0808080808080808	3.27138685432524	5.14616345938329	2.94298279503974e-05	0.000257510994565977	0.00014327679396904	NTRK1/CCNA2/NR4A3/MMP9/PLAU/ITGB7/ATM/CXCL8/MMP3/CDKN1B/TP53/MDM2/PLAT/PDGFA/FLT1/BCL2L1	16
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	17/211	226/8542	0.0752212389380531	3.04521243132156	4.9588665891257	4.15242268017778e-05	0.00035232677286357	0.000196031437533114	VEGFA/PRKCA/RHOA/PDGFRA/IL1R1/IKBKB/CHUK/CXCL8/TP53/CDKN2A/MDM2/RAF1/HLA-A/TNF/PPP3CA/CXCR2/PTGS2	17
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	14/211	163/8542	0.0858895705521472	3.4771028988457	5.08146309620377	4.80953174177135e-05	0.000396079084616464	0.000220374829034724	DDB1/CDK2/CCNA2/PRKCA/MMP9/IKBKB/CHUK/CXCL8/TP53/RAF1/BRAF/TGFBR1/TNF/BCL2	14
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	11/211	105/8542	0.104761904761905	4.24111938614308	5.31793071534341	5.24579069376004e-05	0.000419663255500803	0.000233496848925259	RHOA/PRKCD/IKBKB/CHUK/MDM2/IL12B/RAF1/CLEC7A/TNF/PPP3CA/PTGS2	11
Organismal Systems	Immune system	hsa04611	Platelet activation	12/211	126/8542	0.0952380952380952	3.85556307831189	5.13891209142649	6.18893330966006e-05	0.000481361479640227	0.000267825184160728	RHOA/ITGB1/FCGR2A/F2/FGA/FGB/FGG/COL1A2/COL1A1/COL3A1/PRKCZ/PTGS1	12
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	16/211	212/8542	0.0754716981132075	3.05535187337924	4.82257104508023	6.74885375113825e-05	0.000510724067653705	0.000284162263205821	VEGFA/KDR/PRKCA/RHOA/PDGFRB/PDGFRA/ITGB1/ITGAL/ITGB2/RAF1/BRAF/PDGFA/FLT1/INS/PRKCZ/HGF	16
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/211	73/8542	0.123287671232877	4.99110562877362	5.44986327550402	7.11684491555737e-05	0.000524399099041069	0.000291770927286009	PDGFRB/PDGFRA/TP53/CDKN2A/MDM2/RAF1/BRAF/PDGFA/HGF	9
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/211	75/8542	0.12	4.85800947867299	5.34042922010603	8.82247715835804e-05	0.000633408616497501	0.000352422839254249	CDK2/ATM/ATR/CDK1/TP53/CDKN2A/MDM2/BCL2L1/BCL2	9
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	9/211	77/8542	0.116883116883117	4.73182741429187	5.2348043357394	0.000108588813859184	0.000737790182395978	0.000410499800731597	VEGFA/IKBKB/CHUK/TP53/CDKN2A/RAF1/BRAF/TGFBR1/BCL2L1	9
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	10/211	95/8542	0.105263157894737	4.26141182339736	5.08701734217296	0.000110668527359397	0.000737790182395978	0.000410499800731597	MMP1/MMP9/IKBKB/CHUK/MMP13/CXCL8/MMP3/IL17RA/TNF/PTGS2	10
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	10/211	95/8542	0.105263157894737	4.26141182339736	5.08701734217296	0.000110668527359397	0.000737790182395978	0.000410499800731597	VEGFA/MMP1/ITGAL/ICAM1/ITGB2/CXCL8/MMP3/FLT1/TNFSF13/TNF	10
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	13/211	157/8542	0.0828025477707006	3.35212968273614	4.73376371733582	0.000130476936246429	0.000849617259279072	0.000472719377343243	CDK2/CCNA2/ATM/ATR/CXCL8/CDK1/TP53/CDKN2A/MDM2/RAF1/TGFBR1/HLA-A/PPP3CA	13
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	11/211	120/8542	0.0916666666666667	3.7109794628752	4.75944435250307	0.000176859696734534	0.00112547079740158	0.000626201797050504	NTRK1/NTRK2/RHOA/SHC1/PRKCD/IKBKB/TP53/NTRK3/RAF1/BRAF/BCL2	11
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	7/211	50/8542	0.14	5.66767772511848	5.26778321050111	0.000205773016703201	0.00128036543726436	0.000712383777124533	ITGAL/ICAM1/ITGB2/CXCL8/KLRK1/TNF/HGF	7
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	19/211	312/8542	0.0608974358974359	2.4653360068052	4.19625258838491	0.000250448666479454	0.00151709780107652	0.000844099528418513	VEGFA/PRKCA/RHOA/PDGFRB/PDGFRA/SHC1/MMP9/PLAU/IKBKB/ATM/CDKN1B/CYP1B1/TP53/CDKN2A/MDM2/RAF1/PDGFA/BCL2/PTGS2	19
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/211	37/8542	0.162162162162162	6.56487767388241	5.39841598152414	0.000259304996457772	0.00151709780107652	0.000844099528418513	PRKCA/APOA1/ICAM1/IL12B/LAMA4/TNF	6
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	16/211	238/8542	0.0672268907563025	2.72157393763192	4.28664490386668	0.000260073908755974	0.00151709780107652	0.000844099528418513	MMP1/PRKCA/MASP2/IKBKB/CHUK/FCGR2A/CXCL8/MMP3/F2/FGA/FGB/FGG/IL12B/F13A1/NRP1/TNF	16
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/211	149/8542	0.0805369127516778	3.26040904608925	4.42964151387389	0.000306627727235093	0.00174791729919527	0.00097252541458985	PRKCA/RHOA/PDGFRB/PDGFRA/SHC1/CXCL8/F2/RAF1/CXCR1/PDGFA/INS/CXCR2	12
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	11/211	128/8542	0.0859375	3.4790432464455	4.49712392480675	0.000312128089142013	0.00174791729919527	0.00097252541458985	PDE5A/PDE4A/PDE3A/PDE6H/PDE4D/PDE4B/PDE6A/PDE3B/PDE6C/PDE8B/NPR2	11
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/211	56/8542	0.125	5.06042654028436	4.85133403790203	0.000421531181554582	0.00231428883990751	0.00128764942972297	ITGB2/EEF1A1/CXCL8/HSPA1A/IL12B/HSPA8/TNF	7
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	11/211	133/8542	0.0827067669172932	3.34825214695507	4.34355568563864	0.000434602530874997	0.00234016747394229	0.00130204806820849	CDK2/SKP2/IKBKB/CHUK/ATM/CDKN1B/MDM2/RAF1/BRAF/TGFBR1/INS	11
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	11/211	136/8542	0.0808823529411765	3.27439364371341	4.25488097410472	0.000525796937007623	0.0027777951389082	0.00154554015247524	NTRK1/IKBKB/CHUK/ATM/XIAP/TP53/LMNA/RAF1/TNF/BCL2L1/BCL2	11
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	10/211	119/8542	0.0840336134453782	3.40196742203991	4.19908063474996	0.000696930997924952	0.0035777780262557	0.00199064341310468	ICAM1/MMP9/IKBKB/CHUK/MMP3/XIAP/MMP14/IL18R1/TNF/PTGS2	10
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	8/211	79/8542	0.10126582278481	4.09958605795189	4.4045555870641	0.000702777826585942	0.0035777780262557	0.00199064341310468	ITGB1/ITGB2/EEF1A1/FCGR2A/IL12B/FCGR3A/TNF/PTGS2	8
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	15/211	250/8542	0.06	2.42900473933649	3.64939647409541	0.00131144425354834	0.0065572212677417	0.00364837875047283	RHOA/ITGB1/IL1R1/PRKCD/PRKCQ/IKBKB/CHUK/ATM/CXCL8/MAP1LC3A/TP53/MDM2/TNF/BCL2L1/BCL2	15
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	13/211	204/8542	0.0637254901960784	2.57982529504693	3.6344627562081	0.001600636604831	0.007862776304433	0.00437477779344392	CDK2/CCNA2/SKP2/ITGAL/ICAM1/IKBKB/CHUK/CDKN1B/TP53/MDM2/HLA-A/TNF/BCL2	13
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/211	71/8542	0.0985915492957746	3.99132234163273	4.02783869204374	0.00176924045850691	0.00844740803163621	0.00470006161158706	CYP3A4/CYP1A1/CYP1A2/CYP2C9/CYP2C19/CYP1B1/PTGS2	7
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	14/211	232/8542	0.0603448275862069	2.442964536689	3.54606065261715	0.00179221944101218	0.00844740803163621	0.00470006161158706	ITGA1/RHOA/PDGFRB/PDGFRA/MYH9/ITGB1/ITGAL/ITGB2/ITGB7/F2/RAF1/BRAF/PDGFA/INS	14
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	11/211	158/8542	0.069620253164557	2.81846541484192	3.67159674090304	0.00181015886392204	0.00844740803163621	0.00470006161158706	CDC7/CDK2/CCNA2/SKP2/ATM/ATR/CDK1/CDKN1B/TP53/CDKN2A/MDM2	11
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	7/211	73/8542	0.0958904109589041	3.8819710446017	3.93533762770067	0.00207953722297434	0.0095454167611937	0.00531098376186717	MAOA/MAOB/CYP3A4/CYP1A2/CYP2C9/CYP2C19/CYP2D6	7
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	10/211	139/8542	0.0719424460431655	2.91247570663848	3.61770513987261	0.00227711429122742	0.0101205079610108	0.0056309593166526	MMP2/SHC1/MMP9/ESR1/PRKCD/HSPA1A/ESR2/RAF1/HSPA8/BCL2	10
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/211	139/8542	0.0719424460431655	2.91247570663848	3.61770513987261	0.00227711429122742	0.0101205079610108	0.0056309593166526	CDK2/IKBKB/CHUK/HSPA1A/CDKN1B/TP53/IL12B/HSPA8/BCL2L1/BCL2	10
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	13/211	213/8542	0.0610328638497653	2.47081859243931	3.45938982033788	0.00234929679890734	0.0102781734952196	0.00571868299734025	DDB1/PRKCA/IKBKB/CHUK/ATM/ATR/CDK1/RAF1/HLA-A/TNF/PPP3CA/BCL2L1/BCL2	13
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/211	75/8542	0.0933333333333333	3.77845181674566	3.84605723517013	0.00243035859681882	0.0104692370324503	0.00582498902557385	ATM/XIAP/TP53/CDKN2A/MDM2/BCL2L1/BCL2	7
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	13/211	215/8542	0.0604651162790698	2.44783423343988	3.42169117823461	0.00254974151267645	0.010817085205294	0.00601852861046435	VEGFA/PRKCA/ESR1/ESR2/XIAP/CYP3A4/CYP1A1/CYP1A2/CYP1B1/RAF1/AHR/AR/BCL2	13
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	11/211	166/8542	0.0662650602409639	2.68263575629532	3.48395746816777	0.00267225181256864	0.0111676195152122	0.00621356273778727	PDE5A/PDE3A/PDE3B/RHOA/EDNRA/MYH7/RAF1/INS/PPP3CA/NPR2/ADORA3	11
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	12/211	193/8542	0.0621761658031088	2.51710335682538	3.39252935807887	0.00294584564388028	0.0121202543534569	0.00674360016658504	RHOA/SHC1/PRKCD/IKBKB/CHUK/CXCL8/RAF1/BRAF/CXCR1/PF4/CXCR2/PRKCZ	12
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/211	99/8542	0.0808080808080808	3.27138685432524	3.61748993943747	0.00303006358836422	0.0121202543534569	0.00674360016658504	NTRK1/PRKCA/IL1R1/PRKCD/PRKCH/PRKCQ/HTR2A/TRPA1	8
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/211	99/8542	0.0808080808080808	3.27138685432524	3.61748993943747	0.00303006358836422	0.0121202543534569	0.00674360016658504	TPM3/ITGA1/ITGB1/ITGB7/LMNA/MYH7/LAMA1/TNF	8
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	11/211	170/8542	0.0647058823529412	2.61951491497073	3.39423434972279	0.00321356146099267	0.0126732001278584	0.00705125420647761	PRKCA/SHC1/SMARCA4/TP53/CDKN2A/IGF2/RAF1/BRAF/TGFBR1/HGF/BCL2L1	11
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/211	79/8542	0.0886075949367089	3.5871378007079	3.67635937236803	0.00326727420267824	0.0127060663437487	0.00706954067246169	CYP3A4/CYP1A1/CYP1A2/CYP2C9/CYP2D6/CYP1B1/CYP2S1	7
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	12/211	196/8542	0.0612244897959184	2.47857626462907	3.33257242969793	0.00334166900879435	0.012817360581677	0.00713146378228644	VEGFA/ICAM1/IKBKB/CHUK/CXCL8/MAP1LC3A/TP53/RAF1/MICA/HLA-A/PPP3CA/PTGS2	12
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/211	60/8542	0.1	4.04834123222749	3.77083120978231	0.00348757522168344	0.0131962305685319	0.00734226362459672	VEGFA/KDR/PRKCA/RAF1/PPP3CA/PTGS2	6
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/211	42/8542	0.119047619047619	4.81945384788987	3.94878483654915	0.00354662753500802	0.0132407427973633	0.00736702982710437	MAOA/MAOB/CYP1A1/CYP1A2/CYP1B1	5
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/211	102/8542	0.0784313725490196	3.17516959390391	3.51697278481529	0.00364501980809525	0.0134290203456141	0.00747178575620634	ITGAL/ICAM1/ITGB2/MASP2/FCGR2A/FGG/FCGR3A/PLG	8
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/211	43/8542	0.116279069767442	4.70737352584592	3.87849895577102	0.00393419059146975	0.0143061476053445	0.00795981144959019	APOA1/PLA2G2A/PLA2G5/PLA2G10/ABCA1	5
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	14/211	254/8542	0.0551181102362205	2.23136918311751	3.17049657939983	0.00410020494288446	0.0147186844103545	0.00818934320576114	VEGFA/KDR/NTRK1/NTRK2/PRKCA/PDGFRB/PDGFRA/EDNRA/NTRK3/HTR2A/PDGFA/FLT1/PPP3CA/HGF	14
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/211	105/8542	0.0761904761904762	3.08445046264952	3.42010330977863	0.00435253709985616	0.0154267137716421	0.00858328435414673	TPM3/ITGA1/ITGB1/ITGB7/LMNA/MYH7/LAMA1/TNF	8
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	8/211	106/8542	0.0754716981132075	3.05535187337924	3.38858084582532	0.00461045852608419	0.0161366048412947	0.00897826134026922	PRKCA/RHOA/CPB2/PLA2G2A/PLA2G5/PLA2G10/CTRL/CA2	8
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/211	109/8542	0.073394495412844	2.97125961998348	3.29619613573506	0.00545511085696081	0.018857173332704	0.0104919611024068	IL1R1/PRKCQ/RORA/IKBKB/CHUK/TGFBR1/PPP3CA/AHR	8
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/211	47/8542	0.106382978723404	4.30674599173137	3.61755459853638	0.00579017127249736	0.0196944401653211	0.0109578088137877	PRKCD/IKBKB/INS/TNF/PRKCZ	5
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	11/211	184/8542	0.0597826086956522	2.4202039975273	3.09924193828359	0.00583799476329161	0.0196944401653211	0.0109578088137877	PRKCA/RHOA/ITGB1/EPHB2/EPHB3/EPHB1/EPHB4/RAF1/NRP1/PPP3CA/PRKCZ	11
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/211	69/8542	0.0869565217391304	3.52029672367608	3.34506559416977	0.00695534202261504	0.0231844734087168	0.0128996318213913	PRKCA/MAOA/MAOB/PDYN/PPP3CA/SLC6A3	6
Human Diseases	Substance dependence	hsa05032	Morphine addiction	7/211	91/8542	0.0769230769230769	3.11410864017499	3.22656908092701	0.00712091489566087	0.0234571314210005	0.0130513362793537	PDE4A/PDE3A/PDE4D/PDE4B/PDE3B/PDE8B/PRKCA	7
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/211	70/8542	0.0857142857142857	3.4700067704807	3.30218356437581	0.00745475647632559	0.0242713001554787	0.013504332417334	ITGAL/ICAM1/ITGB2/MYH7/LAMA1/HLA-A	6
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/211	92/8542	0.0760869565217391	3.08025963321657	3.19249423988349	0.00755022807459434	0.0242995846078898	0.0135200696314575	PRKCA/PDGFRB/PDGFRA/CDK1/HTR2A/RAF1/PDGFA	7
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/211	116/8542	0.0689655172413793	2.79195947050172	3.09238438321106	0.00788301178421716	0.0250823102225091	0.0139555711012457	MMP2/PRKCA/RHOA/ITGB1/ITGAL/ICAM1/ITGB2/MMP9	8
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/211	71/8542	0.0845070422535211	3.4211334356852	3.26007491574138	0.00797957333950885	0.0251042756748593	0.0139677924807488	NTRK1/PDGFRB/PDGFRA/TP53/NTRK3/RAF1	6
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/211	52/8542	0.0961538461538462	3.89263580021874	3.32957348906364	0.00888475506777198	0.0276414602108462	0.0153794590646813	CYP1A1/CYP1B1/INS/ALOX5/PTGS2	5
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/211	73/8542	0.0821917808219178	3.32740375251574	3.178074803799	0.00910818312730227	0.0280251788532378	0.0155929566551849	PRKCA/TP53/CDKN2A/RAF1/BRAF/HGF	6
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/211	18/8542	0.166666666666667	6.74723538704581	3.88436952412053	0.00921920059963068	0.0280584366075716	0.0156114609696263	HEXA/MAN2B1/MANBA	3
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	8/211	122/8542	0.0655737704918033	2.65464998834589	2.92938889943511	0.0105450853511291	0.0314108925352781	0.0174767372000795	PRKCA/RHOA/TP53/RAF1/TNF/PRKCZ/BCL2/ADORA3	8
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	8/211	122/8542	0.0655737704918033	2.65464998834589	2.92938889943511	0.0105450853511291	0.0314108925352781	0.0174767372000795	PRKCA/ESR1/THRA/TP53/MYH7/MDM2/THRB/RAF1	8
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	9/211	150/8542	0.06	2.42900473933649	2.80991758635572	0.0119115773359652	0.0351078068849502	0.0195336669886189	CDK2/SHC1/CDKN1B/TP53/RAF1/BRAF/TGFBR1/HGF/BCL2	9
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/211	78/8542	0.0769230769230769	3.11410864017499	2.98492756422323	0.0124220274593021	0.0361432168959293	0.0201097597766825	RHOA/ITGB1/ITGB2/CXCL8/IL12B/TNF	6
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/211	37/8542	0.108108108108108	4.37658511592161	3.275581624789	0.0126297879138367	0.0361432168959293	0.0201097597766825	NTRK1/TPM3/TP53/BRAF	4
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	11/211	205/8542	0.0536585365853659	2.17228066119524	2.70365113458702	0.0126501259135753	0.0361432168959293	0.0201097597766825	DDB1/CDK2/CCNA2/SKP2/RHOA/CDK1/CDKN1B/TP53/CDKN2A/MDM2/HLA-A	11
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	10/211	182/8542	0.0549450549450549	2.22436331441071	2.65698978648534	0.014673241704914	0.0415000775492516	0.0230902687116137	RHOA/ITGB2/FCGR2A/IL12B/RAF1/CLEC7A/FCGR3A/TNF/PPP3CA/BCL2	10
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/211	59/8542	0.0847457627118644	3.43079765443007	2.98158436432455	0.0149056415051669	0.0417357962144674	0.0232214204501548	FABP4/PDE3B/INS/PTGS1/PTGS2	5
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	9/211	158/8542	0.0569620253164557	2.30601715759794	2.63693128297239	0.0162834808257495	0.0451423230812858	0.0251167812632718	PRKCA/SKP2/RHOA/IKBKB/CHUK/RAF1/BRAF/INS/TNF	9
Cellular Processes	Transport and catabolism	hsa04142	Lysosome	8/211	133/8542	0.0601503759398496	2.43509247051277	2.65448668610639	0.0170768610620944	0.0468776578175141	0.0260823058533537	HEXA/PSAP/CTSA/GLA/MAN2B1/ARSA/MANBA/LIPA	8
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/211	23/8542	0.130434782608696	5.28044508551412	3.27118841908267	0.0182811451768376	0.0496963169855779	0.0276505823829531	CTSA/ANPEP/LNPEP	3