{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["S4"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"S4","index":0,"n_rows":172,"n_cols":4,"rows_kept":172,"flags":["formulas_cached_only"]}
["Subclass","p.value","LUCA.Mean","Modern.Life.Mean"]
["1-hydroxy-2-unsubstituted benzenoids",0.00727110777322912,0,0.00222968432185156]
["1-hydroxy-4-unsubstituted benzenoids",0.00717872847066845,0,0.00221793179271146]
["1,3,5-triazines",0.745055236107321,0,{"v":4.45026923753993e-05,"d":"4.45E-05"}]
["1,4-dihydroxy-2-halobenzenoids",0.694703194047038,0,{"v":6.61129296973584e-05,"d":"6.61E-05"}]
["2-phenoxypropionic acids",0.95989525937061,0,{"v":2.41844970604928e-06,"d":"2.42E-06"}]
["Acrylic acids and derivatives",0.151640242217239,0.00422076945505885,0.00690820638421508]
["Acyl chlorides",0.0133612258161867,0,0.00193870060211407]
["Alcohols and polyols",0.00517509654034794,0.00805691919212522,0.0187486155589817]
["Alkanes",0.289321127583512,0,0.000439385385125043]
["Alkylthiols",0.000757078030549377,0,0.00313109054778797]
["Alpha hydroxy acids and derivatives",0.000766135506239225,0.00924739538260141,0.0207030225848578]
["Alpha-halocarboxylic acids and derivatives",0.000455376124534838,0,0.00495171446194499]
["Alpha-keto acids and derivatives",0.057406576691183,0.0266265821506818,0.0186978841606432]
["Amines",0.0148596281477544,0.0212806648376603,0.0289926689984841]
["Amino acids, peptides, and analogues",0.218297015175834,0.201954680321948,0.144928802806831]
["Aminotriazines",0.832046085786825,0,{"v":2.03890922843067e-05,"d":"2.04E-05"}]
["Aminoxides",0.338626446125627,0,0.000456297602248825]
["Androstane steroids",0.205073900716684,0,0.00154224974985817]
["Aniline and substituted anilines",0.333319402427597,0,0.000393299329440909]
["Arylsulfates",0.322688746360348,0,0.000462784690957178]
["Benzenediols",0.000225301841152587,0,0.00970785664951106]
["Benzenesulfonic acids and derivatives",0.119401470094256,0,0.000984233110642348]
["Benzo-p-dioxins",0.942066968500729,0,{"v":2.35228136234062e-06,"d":"2.35E-06"}]
["Benzoic acids and derivatives",0.211449692820199,0.00844153891011771,0.0142461287253479]
["Benzonitriles",0.00180272508102029,0.00422076945505885,0.000780047522612185]
["Benzoxazinones",0.901245723546748,0,{"v":5.88213256694031e-06,"d":"5.88E-06"}]
["Benzoyl derivatives",0.193424005805489,0,0.00193137254482574]
["Benzyl alcohols",0.0485998137785323,0,0.00252893635673173]
["Benzyl cyanides",0.00183892405387518,0.00422076945505885,0.000619403635939169]
["Benzylisoquinolines",0.978854939907348,0,{"v":3.57296111653606e-07,"d":"3.57E-07"}]
["Benzyloxycarbonyls",0.95989525937061,0,{"v":1.46447469501575e-06,"d":"1.46E-06"}]
["Beta hydroxy acids and derivatives",0.000116802133213419,0,0.00977077239882096]
["Beta lactams",0.875322923511273,0,{"v":1.12713645489892e-05,"d":"1.13E-05"}]
["Biphenyls and derivatives",0.85204763087816,0,{"v":2.76269021803435e-05,"d":"2.76E-05"}]
["Branched unsaturated hydrocarbons",0.76688982405472,0,{"v":3.57865728045534e-05,"d":"3.58E-05"}]
["Bromohydrins",0.500919769679701,0,0.000171560148616844]
["Carbohydrates and carbohydrate conjugates",0.0862401142950546,0.0703603854793084,0.0572870987942084]
["Carbonyl compounds",0.00283992712042095,0.0353627992665714,0.069940661081456]
["Carboximidic acids",0.674698774653127,0.0126623083651766,0.00886467553285786]
["Carboxylic acid derivatives",0.0418706780046727,0,0.00163679741890194]
["Carboxylic acids",0.33481699742541,0.0299899627737318,0.0244970419593794]
["Chalcones and dihydrochalcones",0.729161628431737,0,{"v":4.44251006287601e-05,"d":"4.44E-05"}]
["Chlorohydrins",0.701018564471593,0.00922514349119064,0.00728765578461057]
["Cinnamic acids",0.114011052600373,0,0.000934668643537041]
["Cresols",0.0666491835097903,0,0.00161045914257289]
["Cyanates",0.233802829626667,0,0.000535993575288427]
["Cycloalkanes",0.363355222242082,0,0.000327860382536064]
["Cyclohexyl halides",0.408041363676709,0,0.000279734376141726]
["Cyclopropanecarboxylic acids and derivatives",0.913805691687998,0,{"v":5.75504359322981e-06,"d":"5.76E-06"}]
["Dialkylthioethers",0.2596665370361,0,0.000557225360798504]
["Dibenzazepines",0.35636120874477,0,0.000309997905429292]
["Dibenzofurans",0.942066968500729,0,{"v":2.35228136234062e-06,"d":"2.35E-06"}]
["Dibenzothiophenes",0.917246262501206,0,{"v":4.31450284391963e-06,"d":"4.31E-06"}]
["Dicarboxylic acids and derivatives",0.676950160984009,0.0218198668775702,0.0223863432766922]
["Diphenylethers","NaN",0,0]
["Diphenylmethanes",0.882487838684167,0,{"v":8.91484390838469e-06,"d":"8.91E-06"}]
["Diterpenoids",0.703824011221119,0,{"v":7.19843242771157e-05,"d":"7.20E-05"}]
["Fatty acid esters",0.362072043206863,0,0.000337453358494376]
["Fatty acids and conjugates",{"v":3.24904092011788e-05,"d":"3.25E-05"},0.00807917108353599,0.0291892794583736]
["Fatty alcohols",0.569270408032301,0.00922514349119064,0.00626680903852968]
["Fatty aldehydes",0.230748382194747,0,0.0010882279910721]
["Flavans",0.729161628431737,0,{"v":8.81054476741384e-05,"d":"8.81E-05"}]
["Furanones",0.0160026017223501,0,0.0107173853167601]
["Furoic acid and derivatives",0.653149094403499,0,{"v":9.29698224628683e-05,"d":"9.30E-05"}]
["Gamma butyrolactones",0.947334628633119,0,{"v":4.32142337954803e-06,"d":"4.32E-06"}]
["Gamma-keto acids and derivatives",0.907310366809309,0,{"v":6.89619174253499e-06,"d":"6.90E-06"}]
["Glycerophosphates",0.0264171282672445,0.0034443474465299,0.00715984623064243]
["Guanidines",0.8955367620425,0,{"v":6.64272017787505e-06,"d":"6.64E-06"}]
["Halobenzenes",0.478500825249585,0,0.000191008602701264]
["Halogen hydrides",0.000370863783488872,0,0.00518638043146389]
["Halomethanes",0.303541081195285,0,0.000438357631927449]
["Halophenols",0.475350215460743,0,0.000195410468913987]
["Hydrazines and derivatives",0.507252645685364,0,0.000166116112319979]
["Hydropyridines",0.166726760103996,0,0.000968445793262306]
["Hydroxycinnamic acids and derivatives",0.806735472373188,0,{"v":2.36533008583259e-05,"d":"2.37E-05"}]
["Hydroxycoumarins",0.91380569064583,0,{"v":4.48818095468925e-06,"d":"4.49E-06"}]
["Imidazoles",0.0207990912711631,0.0273555314222251,0.0164002905370524]
["Imidazolidines",0.167391639632299,0.000862068965517241,0.00236268378425617]
["Imidazolines",0.0282149257199456,0,0.00158006146494614]
["Imines",0.50285589801774,0,0.000174252987560183]
["Indoles",0.514555530072981,0.00844153891011771,0.00493277665005345]
["Indolines",0.81425767317496,0,{"v":2.42187144225746e-05,"d":"2.42E-05"}]
["Indolyl carboxylic acids and derivatives",0.736447558744403,0,{"v":4.24398016264029e-05,"d":"4.24E-05"}]
["Isofamides",0.356361213034478,0,0.000319787490982124]
["Isoprenoid phosphates",0.907566511815067,0.0193065840661111,0.0187633794725194]
["Isoquinolones and derivatives",0.184673705610262,0,0.000665063223937318]
["Ketene acetals",0.726104510821084,0,{"v":4.62068762117128e-05,"d":"4.62E-05"}]
["Lineolic acids and derivatives",0.748366165106024,0,{"v":3.80430684184965e-05,"d":"3.80E-05"}]
["Lipoamides",0.0320712698113468,0.0123819953044926,0.00460133242654538]
["Lipoic acids and derivatives",0.541279560289044,0.0034443474465299,0.00209727620540464]
["Medium-chain hydroxy acids and derivatives",0.00265193797920927,0,0.00257607866665168]
["Medium-chain keto acids and derivatives",0.182869282926005,0,0.00127698201312549]
["Methoxybenzenes",0.967963421248709,0,{"v":7.97976015300134e-07,"d":"7.98E-07"}]
["Methoxyphenols",0.0324913741805062,0,0.0019379644295434]
["Miscellaneous metallic oxoanionic compounds",{"v":1.87574238532983e-05,"d":"1.88E-05"},0,0.0102596073974388]
["Monoterpenoids",0.00181972905766767,0,0.00922570456205014]
["Nitrobenzenes",0.292364398072201,0,0.000403542710816797]
["Nitrogen mustard compounds",0.642549175747154,0.00922514349119064,0.00679777696991489]
["Nitronaphthalenes",0.00916898622823866,0,0.00440201493703755]
["Nitrophenols",0.00373395666785264,0,0.00231521779366511]
["Non-metal chlorates",0.967963421248709,0,{"v":7.82685882681445e-07,"d":"7.83E-07"}]
["Non-metal chlorites",0.913805691687998,0,{"v":6.75616932937972e-06,"d":"6.76E-06"}]
["Non-metal hypochlorites",0.607992151286838,0,0.000100150578651123]
["Non-metal nitrates",0.00412583780191951,0,0.00229077460698475]
["Non-metal nitrites",0.16681320224523,0.00203029326458266,0.00300377280739036]
["Non-metal phosphates",0.0312861888279401,0.025216816733064,0.00972057560270187]
["Non-metal phosphonates",0.750600227052744,0,{"v":4.55358271758971e-05,"d":"4.55E-05"}]
["Non-metal pyrophosphates",{"v":1.8735753988405e-05,"d":"1.87E-05"},0.025216816733064,0.00553465911018158]
["Non-metal selenates",0.494402685129458,0.00480304793607151,0.00294412544915934]
["Non-metal selenites",0.0439615896322184,0.0174473931741667,0.00523626257174569]
["Non-metal selenophosphates",0.123758844278952,0.00693654326458266,0.00177582173490748]
["Non-metal sulfates",0.171442612774897,0.00580304793607151,0.00374224801531387]
["Non-metal sulfites",0.758548859072784,0.00422076945505885,0.00494825081858366]
["Non-metal superoxides",0.01456241520963,0.0024443474465299,0.00486885624886553]
["Non-metal tetrathionates",0.102666865892122,0,0.00108345716532573]
["Non-metal thiosulfates",0.890425248599684,0.00422076945505885,0.00407348653017819]
["O-methylated flavonoids","NaN",0,0]
["Organic carbonic acids",0.00610082956587828,0.0195090147595514,0.00890704355613543]
["Organic cyanides",0.770291599941704,0.00422076945505885,0.00505194261623466]
["Organic isocyanides",0.452808087286563,0,0.00022182559705724]
["Organic nitro compounds",0.0124311609768501,0,0.00201995535455953]
["Organic phosphonic acids",0.0386191411764042,0,0.00264032261348834]
["Organic phosphoramides",0.35636120874477,0,0.000619995810858584]
["Organic pyrophosphates",0.789831438931287,0,{"v":6.61399352421841e-05,"d":"6.61E-05"}]
["Organoarsenic compounds",0.206346509594047,0,0.000693060146457752]
["Organoselenium compounds",0.0507284258500605,0.0174473931741667,0.00539216152075935]
["Organosulfonic acids and derivatives",0.00145375073175308,0.000862068965517241,0.00619272074711159]
["Other non-metal hydrides",0.0774219603129219,0,0.00142879788995918]
["Other non-metal nitrides",0.0622097575077219,0.00205254515599343,0.00438121858718587]
["Other non-metal oxides",0.00149108489627403,0.0337578903700701,0.0132072904858585]
["Other non-metal sulfides",0.435810271257726,0.00422076945505885,0.0059634597110759]
["Oximes",0.895536761898635,0,{"v":2.48712126488034e-05,"d":"2.49E-05"}]
["Peroxycarboxylic acids and derivatives",0.28982620789577,0,0.00130070641658792]
["Phenethylamines",0.04294168029615,0,0.0012630062009763]
["Phenoxyacetic acid derivatives",0.725093867450725,0,{"v":9.55699648165139e-05,"d":"9.56E-05"}]
["Phenylacetaldehydes",0.444003511484346,0.00461257174559532,0.00588766468700047]
["Phenylacetamides",0.310226826878468,0.00422076945505885,0.0024277317696221]
["Phenylpropanes",0.95989525937061,0,{"v":1.46447469501575e-06,"d":"1.46E-06"}]
["Phenylpyruvic acid derivatives",0.00265567668542688,0.0162882453044926,0.005622681766881]
["Phosphate esters",0.478410150668996,0.0580348484606015,0.0493725301497241]
["Piperidinecarboxylic acids and derivatives",0.118729721869389,0,0.000939587726227049]
["Purines and purine derivatives",0.171392264627729,0.0391389280228248,0.0334957608162327]
["Pyranones and derivatives",0.937240980010706,0,{"v":5.14005722012905e-06,"d":"5.14E-06"}]
["Pyrazines",0.947334628771297,0,{"v":1.6839066093078e-06,"d":"1.68E-06"}]
["Pyrazinium compounds",0.858007135702534,0,{"v":1.4219851331325e-05,"d":"1.42E-05"}]
["Pyridinecarboxylic acids and derivatives",0.00232394886062391,0.00491461412151067,0.0146571867335887]
["Pyrimidine deoxyribonucleotides",0.00273850984494827,0,0.00250673092473727]
["Pyrimidines and pyrimidine derivatives",0.674894169323301,0.0265798986771634,0.0323724978961016]
["Pyrrolidinylpyridines",0.882487838620169,0,{"v":1.8693395003188e-05,"d":"1.87E-05"}]
["Pyrrolo[2,3-d]pyrimidines",0.00552572835967291,0,0.00251938771754321]
["Quaternary ammonium salts",0.802506559332517,0.00922514349119064,0.0103635815870833]
["Quinonimines",0.890128040397119,0,{"v":7.01336874741447e-06,"d":"7.01E-06"}]
["Sesquiterpenoids",0.00460852133826334,0,0.00323272903742952]
["Short-chain keto acids and derivatives",0.80309421193796,0.0497664939413374,0.0521817600287335]
["Styrenes",0.650071765720191,0,{"v":9.64871605592068e-05,"d":"9.65E-05"}]
["Substituted pyrroles",0.814257669598907,0,{"v":2.12671387522911e-05,"d":"2.13E-05"}]
["Sulfanilides",0.602702838970958,0,0.000103716534127268]
["Sulfinic acids",0.558081186758076,0.000862068965517241,0.000929207539419378]
["Sulfones",0.369519472348647,0,0.000316395951535513]
["Sulfuric acid esters",0.340116693171205,0,0.000366737451217572]
["Terpene lactones",0.953192144074014,0,{"v":1.37983749962225e-06,"d":"1.38E-06"}]
["Thiazoles",0.161567442045772,0.0236519788029532,0.00888347355670973]
["Thiophosphoric acid esters",0.334784498817833,0,0.000516404107493899]
["Toluenes",0.523360728155688,0,0.000184230432080563]
["Transition metal alkyls",0.730189280849299,0,{"v":5.48072878279188e-05,"d":"5.48E-05"}]
["Triazinones",0.832046085786825,0,{"v":4.02942518604243e-05,"d":"4.03E-05"}]
["Tyrosols and derivatives",0.404382419742045,0,0.000292676762681246]
["Unsaturated aliphatic hydrocarbons",0.314058090117504,0,0.000514398260547598]
["Ureas",0.283255696423065,0.00361257174559532,0.00529553742824674]
["Vinyl chlorides",0.895103898458235,0.00922514349119064,0.00919268677020249]
["Xylenes",0.100131656292093,0,0.00104657807297171]