LOCUS eG101_heavy_variable 405 bp mRNA linear PRI 23-JUN-2022 DEFINITION Homo sapiens 2M18 monoclonal AChR-binding IgG1 antibody heavy chain mRNA, partial cds. ACCESSION eG101_heavy_variable VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 405) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities JOURNAL unpublished REFERENCE 2 (bases 1 to 405) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Direct Submission JOURNAL Submitted (23-JUN-2022) Department of Biomedicine, University of Basel, Hebelstrasse 20, Basel, 4031, Switzerland COMMENT Bankit Comment: ALT EMAIL:tobias.derfuss@usb.ch Bankit Comment: TOTAL # OF SEQS:12 ##Assembly-Data-START## Assembly Method :: EGAssembler v. https://www.genome.jp/tools- bin/eassembler4.cgi 2019 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..405 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 1..405 /codon_start=1 /product="immunoglobulin heavy chain" /translation="MEFGLTWLFLVAILKGVQCEVQLLESGGGLVQPGGSLRLSCAAS EFPFSTYAMTWVRQAPGKGLEWVSGISGNGGNTDYADSVKGRFTVSRDNSKNTLYLQM NSLRVDDTAVYYCATRRIFMDVWGKGTTVTVSS" BASE COUNT 83 a 96 c 126 g 100 t ORIGIN 1 atggagtttg ggctgacctg gctttttctt gtggctattt taaaaggtgt ccagtgtgag 61 gtgcagctgt tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctct 121 tgtgcagcct ctgaattccc ctttagtacc tatgccatga cctgggtccg gcaggctcca 181 gggaaggggc tggagtgggt ctcaggtatt agtggtaatg gtggtaatac agactacgca 241 gactccgtga agggccggtt caccgtctcc agagacaatt ccaagaacac gctgtacttg 301 caaatgaaca gcctgagagt cgatgacacg gccgtatatt actgtgccac ccggcggata 361 ttcatggacg tctggggcaa agggaccacg gtcaccgtct cctca // LOCUS eG101_kappa_variable 384 bp mRNA linear PRI 23-JUN-2022 DEFINITION Homo sapiens 2M18 monoclonal AChR-binding IgG1 antibody kappa chain mRNA, partial cds. ACCESSION eG101_kappa_variable VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 384) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities JOURNAL unpublished REFERENCE 2 (bases 1 to 384) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Direct Submission JOURNAL Submitted (23-JUN-2022) Department of Biomedicine, University of Basel, Hebelstrasse 20, Basel, 4031, Switzerland COMMENT Bankit Comment: ALT EMAIL:tobias.derfuss@usb.ch Bankit Comment: TOTAL # OF SEQS:12 ##Assembly-Data-START## Assembly Method :: EGAssembler v. https://www.genome.jp/tools- bin/eassembler4.cgi 2019 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..384 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 1..384 /codon_start=1 /product="immunoglobulin kappa chain" /translation="METPAQLLFLLLLWLPDTTGEIVLTQSPGTLSLSPGERATLSCR ASQSVSSSHLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPE DFAVYYCQQYGSSPRTFGQGTKVEIK" BASE COUNT 87 a 115 c 100 g 82 t ORIGIN 1 atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga 61 gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 121 ctctcctgca gggccagtca gagtgttagc agcagccact tagcctggta ccagcagaaa 181 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 241 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 301 cctgaagatt ttgcagtgta ttactgtcag cagtatggta gttcacctcg gacgttcggc 361 caagggacca aggtggaaat caaa // LOCUS bG401_heavy_variable 429 bp mRNA linear PRI 23-JUN-2022 DEFINITION Homo sapiens 5D2 monoclonal AChR-binding IgG4 antibody heavy chain mRNA, partial cds. ACCESSION bG401_heavy_variable VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 429) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities JOURNAL unpublished REFERENCE 2 (bases 1 to 429) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Direct Submission JOURNAL Submitted (23-JUN-2022) Department of Biomedicine, University of Basel, Hebelstrasse 20, Basel, 4031, Switzerland COMMENT Bankit Comment: ALT EMAIL:tobias.derfuss@usb.ch Bankit Comment: TOTAL # OF SEQS:12 ##Assembly-Data-START## Assembly Method :: EGAssembler v. https://www.genome.jp/tools- bin/eassembler4.cgi 2019 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..429 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 1..429 /codon_start=1 /product="immunoglobulin heavy chain" /translation="MDWTWRILFLVAAATGAPSQVQLIQSGAEVKKPGASVKVSCKAS GYTFTGYYMHWVRQAPGQGLEWMGWINANNGGTNYAQKFQGRVSMTRDTSTYTASMEL SSLRTDDTAVYYCARDRWVHLGSYYFGLDVWGQGTTVTVSS" BASE COUNT 95 a 116 c 131 g 87 t ORIGIN 1 atggactgga cctggaggat cctcttcttg gtggcagcag ccacaggagc cccctcccag 61 gtgcagttga tacagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc 121 tgcaaggcct ctggatacac tttcaccggc tactatatgc actgggtgcg acaggcccct 181 ggacaagggc ttgagtggat gggctggatc aacgctaaca atggtggcac aaactatgca 241 cagaagtttc agggcagggt ctccatgacc agggacacgt ccacttacac agcctccatg 301 gaactgagca gcctgagaac tgacgacacg gccgtgtatt actgtgcgag agatcggtgg 361 gtacatctag ggtcctacta cttcggtctg gacgtctggg gccaagggac cacggtcacc 421 gtctcctca // LOCUS bG401_lambda_variable 402 bp mRNA linear PRI 23-JUN-2022 DEFINITION Homo sapiens 5D2 monoclonal AChR-binding IgG4 antibody lambda chain mRNA, partial cds. ACCESSION bG401_lambda_variable VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 402) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities JOURNAL unpublished REFERENCE 2 (bases 1 to 402) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Direct Submission JOURNAL Submitted (23-JUN-2022) Department of Biomedicine, University of Basel, Hebelstrasse 20, Basel, 4031, Switzerland COMMENT Bankit Comment: ALT EMAIL:tobias.derfuss@usb.ch Bankit Comment: TOTAL # OF SEQS:12 ##Assembly-Data-START## Assembly Method :: EGAssembler v. https://www.genome.jp/tools- bin/eassembler4.cgi 2019 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..402 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 1..402 /codon_start=1 /product="immunoglobulin lambda chain" /translation="MAWTPLLLLFLSHCTGSLSQAVLTQPSSLSASPGASASLTCTLR SGINVDTYRIYWYQQKPGSPPQYLLRYKSDSDKQQGSGVPSRFSGSKDASANAGTLLI SGLQSEDEADYYCVIWHSSAWVFGGGTKLTVL" BASE COUNT 80 a 124 c 98 g 100 t ORIGIN 1 atggcctgga ctcctctcct cctcctgttc ctctctcact gcacaggttc cctctcgcag 61 gctgtgctga ctcagccgtc ttccctctct gcatctcctg gagcatcagc cagtctcacc 121 tgcaccttac gcagtggcat caatgttgat acctacagga tatactggta ccagcagaag 181 ccagggagtc ctccccagta tctcctgagg tacaaatcag actcagataa acagcagggc 241 tctggagtcc ccagccggtt ctctggatcc aaagatgctt cggccaatgc aggtacttta 301 ctcatctctg ggctccagtc tgaggatgag gctgactatt actgtgtgat ttggcacagc 361 agcgcttggg tgttcggcgg agggaccaaa ctgaccgtcc tg // LOCUS dG101_heavy_variable 426 bp mRNA linear PRI 23-JUN-2022 DEFINITION Homo sapiens 5H10 monoclonal AChR-binding IgG1 antibody heavy chain mRNA, partial cds. ACCESSION dG101_heavy_variable VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 426) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities JOURNAL unpublished REFERENCE 2 (bases 1 to 426) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Direct Submission JOURNAL Submitted (23-JUN-2022) Department of Biomedicine, University of Basel, Hebelstrasse 20, Basel, 4031, Switzerland COMMENT Bankit Comment: ALT EMAIL:tobias.derfuss@usb.ch Bankit Comment: TOTAL # OF SEQS:12 ##Assembly-Data-START## Assembly Method :: EGAssembler v. https://www.genome.jp/tools- bin/eassembler4.cgi 2019 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..426 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 1..426 /codon_start=1 /product="immunoglobulin heavy chain" /translation="MKHLWFFLLLVAAPRWVLSQVQLQESGPGLVKPSETLSLTCTVS GVPIRSYSWSWIRQPAGKGLEWIGRVFTSGSTNYNPSLKSRVTMSVDTSKNQFSLRLS SVTAADTAVYYCARNVGASYYYEYYYMDVWGIGTTVTVSS" BASE COUNT 85 a 121 c 122 g 98 t ORIGIN 1 atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt cctgtcccag 61 gtgcagctgc aggagtcggg cccaggactg gtgaagcctt cggagaccct gtccctcacc 121 tgcactgtct ctggtgtccc catcaggagt tattcctgga gctggatccg acagcccgcc 181 gggaagggac tggagtggat tgggcgtgtc tttactagtg ggagcaccaa ctacaacccc 241 tccctcaaga gtcgagtcac catgtcagta gacacgtcca agaatcaatt ctccctgagg 301 ctgagctctg tgaccgccgc ggacacggcc gtttattact gtgcgagaaa tgtgggggcc 361 agttattatt atgagtacta ctatatggac gtctggggca tagggaccac ggtcaccgtc 421 tcctca // LOCUS dG101_kappa_variable 387 bp mRNA linear PRI 23-JUN-2022 DEFINITION Homo sapiens 5H10 monoclonal AChR-binding IgG1 antibody kappa chain mRNA, partial cds. ACCESSION dG101_kappa_variable VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 387) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities JOURNAL unpublished REFERENCE 2 (bases 1 to 387) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Direct Submission JOURNAL Submitted (23-JUN-2022) Department of Biomedicine, University of Basel, Hebelstrasse 20, Basel, 4031, Switzerland COMMENT Bankit Comment: ALT EMAIL:tobias.derfuss@usb.ch Bankit Comment: TOTAL # OF SEQS:12 ##Assembly-Data-START## Assembly Method :: EGAssembler v. https://www.genome.jp/tools- bin/eassembler4.cgi 2019 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..387 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 1..387 /codon_start=1 /product="immunoglobulin kappa chain" /translation="MDMRVPAQLLGLLLLWFPGSRCDIQMTQSPSSVAASVGDRVAIT CRASQGITTWLAWYQQKPGKAPKLLIYGASNLQSGVPSRFSGRGSGTDFTLTISSLQP EDFATYYCQQANSFPWTFGRGTKVEIK" BASE COUNT 88 a 106 c 104 g 89 t ORIGIN 1 atggacatga gggtccccgc tcagctcctg gggctcctgc tgctctggtt cccaggttcc 61 agatgcgaca tccagatgac ccagtctcca tcttccgtgg ctgcatctgt aggagacaga 121 gtcgccatca cttgtcgggc gagtcagggt attaccactt ggttagcctg gtatcagcag 181 aaaccaggga aagcccctaa gctcctgatc tatggtgcat ccaatttgca aagtggggtc 241 ccatcaaggt tcagcggcag aggatctggg acagatttca ctctcaccat cagcagcctg 301 cagcctgaag attttgcaac ttactattgt caacaggcta acagtttccc gtggacgttc 361 ggccgaggga ccaaggtgga aatcaag // LOCUS bG402_heavy_variable 429 bp mRNA linear PRI 23-JUN-2022 DEFINITION Homo sapiens 6J2 monoclonal AChR-binding IgG4 antibody heavy chain mRNA, partial cds. ACCESSION bG402_heavy_variable VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 429) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities JOURNAL unpublished REFERENCE 2 (bases 1 to 429) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Direct Submission JOURNAL Submitted (23-JUN-2022) Department of Biomedicine, University of Basel, Hebelstrasse 20, Basel, 4031, Switzerland COMMENT Bankit Comment: ALT EMAIL:tobias.derfuss@usb.ch Bankit Comment: TOTAL # OF SEQS:12 ##Assembly-Data-START## Assembly Method :: EGAssembler v. https://www.genome.jp/tools- bin/eassembler4.cgi 2019 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..429 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 1..429 /codon_start=1 /product="immunoglobulin heavy chain" /translation="MDWTWRILFLVAAATGAPSRVQLIQSGAEVKKPGASVKVSCKAS GYTFTAYYLHWVRQAPGQGLEWMGWINGNNGGTNYAQNFQGRVSMTRDTSTYTASMEL SSLRTDDTAVYYCARDRWVHVGSYYFGLDVWGQGTTVTVSS" BASE COUNT 93 a 117 c 132 g 87 t ORIGIN 1 atggactgga cctggaggat cctcttcttg gtggcagcag ccacaggagc cccctcccgg 61 gtgcagttga tacagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc 121 tgcaaggcct ctggatacac tttcaccgcc tactatttgc actgggtgcg acaggcccct 181 ggacaagggc ttgagtggat gggctggatc aacggcaaca atggtggcac aaactatgca 241 cagaattttc agggcagggt ctccatgacc agggacacgt ccacctacac agcctccatg 301 gaactgagca gcctgagaac tgacgacacg gccgtctatt actgtgcgag agatcggtgg 361 gtacatgtgg ggtcatacta cttcggtctg gacgtctggg gccaagggac cacggtcacc 421 gtctcctca // LOCUS bG402_lambda_variable 402 bp mRNA linear PRI 23-JUN-2022 DEFINITION Homo sapiens 6J2 monoclonal AChR-binding IgG4 antibody lambda chain mRNA, partial cds. ACCESSION bG402_lambda_variable VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 402) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities JOURNAL unpublished REFERENCE 2 (bases 1 to 402) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Direct Submission JOURNAL Submitted (23-JUN-2022) Department of Biomedicine, University of Basel, Hebelstrasse 20, Basel, 4031, Switzerland COMMENT Bankit Comment: ALT EMAIL:tobias.derfuss@usb.ch Bankit Comment: TOTAL # OF SEQS:12 ##Assembly-Data-START## Assembly Method :: EGAssembler v. https://www.genome.jp/tools- bin/eassembler4.cgi 2019 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..402 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 1..402 /codon_start=1 /product="immunoglobulin lambda chain" /translation="MAWTPLLLLFLSHCTGSLSQAVLTQPSSLSASPGASARLTCTLR SDINVDTYRIYWYQQKPGSPPQYLLRYKSHSDKQQGSGVPSRFSGSKDASANAGTLVI SGLQSEDEADYYCVIWHSSAWVFGGGTKLTVL" BASE COUNT 84 a 124 c 95 g 99 t ORIGIN 1 atggcctgga ctcctctcct cctcctgttc ctctctcact gcacaggttc cctctcgcag 61 gctgtgctga ctcagccgtc ttccctctct gcatctcctg gagcatcagc cagactcacc 121 tgcaccttac gcagtgacat caatgttgac acctacagaa tatattggta ccagcagaag 181 ccagggagtc ctccccagta tctcctgaga tacaaatcac actcagataa gcaacagggc 241 tctggagtcc ccagccggtt ctctggatcc aaagatgctt cggccaatgc aggtacttta 301 gtcatctctg ggctccagtc tgaggatgag gccgactatt actgtgtgat ttggcacagc 361 agcgcttggg tgttcggcgg agggaccaaa ttgaccgtcc tg // LOCUS bG301_heavy_variable 459 bp mRNA linear PRI 23-JUN-2022 DEFINITION Homo sapiens 3I3 monoclonal AChR-binding IgG3 antibody heavy chain mRNA, partial cds. ACCESSION bG301_heavy_variable VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 459) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities JOURNAL unpublished REFERENCE 2 (bases 1 to 459) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Direct Submission JOURNAL Submitted (23-JUN-2022) Department of Biomedicine, University of Basel, Hebelstrasse 20, Basel, 4031, Switzerland COMMENT Bankit Comment: ALT EMAIL:tobias.derfuss@usb.ch Bankit Comment: TOTAL # OF SEQS:12 ##Assembly-Data-START## Assembly Method :: EGAssembler v. https://www.genome.jp/tools- bin/eassembler4.cgi 2019 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..459 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 1..456 /codon_start=1 /product="immunoglobulin heavy chain" /translation="MEFGLSWIFLAAILKGVQCEVQLVESGGGLVKPGGSLRLSCAAS GFTFTKAWMNWVRQAPGKGLEWVGLIKSKTDGGTTDYAAPVKGRYTLSRDDSKQMVYL QMNSLKAEDTAMYYCTAYPRGLRGVVIMGGEEFHYYGMDVWGQGTTVTVS" BASE COUNT 106 a 102 c 144 g 107 t ORIGIN 1 atggagtttg ggctgagctg gattttcctt gctgctattt taaaaggtgt ccagtgtgag 61 gtgcagctgg tggagtctgg gggaggcttg gtaaagcctg gggggtccct tagactctcc 121 tgtgcagcct ctggattcac tttcactaag gcctggatga actgggtccg ccaggctcca 181 gggaaggggc tggagtgggt tggccttatt aaaagtaaaa ctgatggtgg gacaacagac 241 tacgctgcac ccgtgaaagg cagatacact ctctcgagag atgattcaaa acaaatggtg 301 tatctgcaaa tgaacagcct gaaagccgag gacacagcca tgtattactg taccgcctat 361 ccaagggggc ttcggggagt tgtcataatg ggtggtgagg agttccacta ctacggcatg 421 gacgtctggg gccaagggac cacggtcacc gtctcccca // LOCUS bG301_kappa_variable 369 bp mRNA linear PRI 23-JUN-2022 DEFINITION Homo sapiens 3I3 monoclonal AChR-binding IgG3 antibody kappa chain mRNA, partial cds. ACCESSION bG301_kappa_variable VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 369) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities JOURNAL unpublished REFERENCE 2 (bases 1 to 369) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Direct Submission JOURNAL Submitted (23-JUN-2022) Department of Biomedicine, University of Basel, Hebelstrasse 20, Basel, 4031, Switzerland COMMENT Bankit Comment: ALT EMAIL:tobias.derfuss@usb.ch Bankit Comment: TOTAL # OF SEQS:12 ##Assembly-Data-START## Assembly Method :: EGAssembler v. https://www.genome.jp/tools- bin/eassembler4.cgi 2019 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..369 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 1..369 /codon_start=1 /product="immunoglobulin kappa chain" /translation="MRVPAQLLGLLLLWLPGARCDIQLTQSPSFLSASVGDRVTITCR ASQAISSYLAWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSGTAFTLTISSLQPED FATYYCQQLNSFGQGTRLEIK" BASE COUNT 87 a 105 c 89 g 88 t ORIGIN 1 atgagggtcc ccgctcagct cctggggctc ctgctgctct ggctcccagg tgccagatgt 61 gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 121 atcacttgcc gggccagtca ggccattagc agttatttag cctggtatca gcaaaaacca 181 gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca 241 aggttcagcg gcagtggatc tgggacagca ttcactctca caatcagcag cctgcagcct 301 gaagattttg caacttatta ctgtcaacag cttaatagtt tcggccaagg gacacgactg 361 gagattaaa // LOCUS aG101_heavy_variable 447 bp mRNA linear PRI 23-JUN-2022 DEFINITION Homo sapiens 1J7 monoclonal AChR-binding IgG1 antibody heavy chain mRNA, partial cds. ACCESSION aG101_heavy_variable VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 447) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities JOURNAL unpublished REFERENCE 2 (bases 1 to 447) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Direct Submission JOURNAL Submitted (23-JUN-2022) Department of Biomedicine, University of Basel, Hebelstrasse 20, Basel, 4031, Switzerland COMMENT Bankit Comment: ALT EMAIL:tobias.derfuss@usb.ch Bankit Comment: TOTAL # OF SEQS:12 ##Assembly-Data-START## Assembly Method :: EGAssembler v. https://www.genome.jp/tools- bin/eassembler4.cgi 2019 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..447 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 1..447 /codon_start=1 /product="immunoglobulin heavy chain" /translation="MEFGLSWVFLVALLRGVQCQVQLVESGGGVVQPGRSLRLSCFVS GFTFKTYNMYWVRQAPGKGLEWLTIIWYDGTIKFYSDSVRGRFTISRDNSQNTLYLEM NSLRVEDTAVYFCGREMSAAYSSNWARGEFSYGIDVWGQGTTVIVSS" BASE COUNT 99 a 100 c 135 g 113 t ORIGIN 1 atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgtcag 61 gtgcagttgg tggagtcggg ggggggcgtg gtccagcctg ggaggtccct gagactctcc 121 tgttttgtct ctggattcac cttcaagacc tataatatgt actgggtccg ccaggctcca 181 ggcaaggggc tggagtggct gacaattata tggtatgacg gcaccattaa attctattcg 241 gactccgtga ggggccgatt caccatctcc agagacaact cccagaatac actatatctc 301 gaaatgaaca gtctgagagt cgaggacacg gctgtatatt tttgtgggag agaaatgagc 361 gcagcctaca gcagcaactg ggccagggga gaattttcat atggcataga cgtctggggc 421 caagggacta cggtcatcgt ctcctca // LOCUS aG101_kappa_variable 387 bp mRNA linear PRI 23-JUN-2022 DEFINITION Homo sapiens 1J7 monoclonal AChR-binding IgG1 antibody kappa chain mRNA, partial cds. ACCESSION aG101_kappa_variable VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 387) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificities JOURNAL unpublished REFERENCE 2 (bases 1 to 387) AUTHORS Sanderson,N.S.R., Rose,N., Holdermann,S. and Derfuss,T. TITLE Direct Submission JOURNAL Submitted (23-JUN-2022) Department of Biomedicine, University of Basel, Hebelstrasse 20, Basel, 4031, Switzerland COMMENT Bankit Comment: ALT EMAIL:tobias.derfuss@usb.ch Bankit Comment: TOTAL # OF SEQS:12 ##Assembly-Data-START## Assembly Method :: EGAssembler v. https://www.genome.jp/tools- bin/eassembler4.cgi 2019 Sequencing Technology :: Illumina ##Assembly-Data-END## FEATURES Location/Qualifiers source 1..387 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" CDS 1..387 /codon_start=1 /product="immunoglobulin kappa chain" /translation="METPAQLLFLLLLWLPDTAGKIVLTQSPDTLSLSPGERGTLSCR ATQSLGGTSLAWYQQKPGQAPRLLIYSASRRATGIPDRFSGSVSGTNFTLSIAGLEPE DSAVYYCQQYEPTPMWTFGQGTRVEIK" BASE COUNT 88 a 119 c 95 g 85 t ORIGIN 1 atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga caccgccgga 61 aaaattgtgt tgacgcagtc tccggacacc ctgtctttgt ctccagggga aagaggcacc 121 ctctcttgta gggccactca gagtcttggc ggcacctctt tagcctggta ccagcagaaa 181 cctggccagg cccccagact cctcatctat agtgcatcca ggcgggccac tggcatccca 241 gacagattca gtggcagtgt gtctgggaca aacttcactc tctccatcgc cggactggag 301 cctgaagatt ctgcagtata ttactgtcaa caatatgaac ctacacctat gtggacgttc 361 ggccaaggga ccagggtgga gatcaaa //