Model (all analyses): lm(formula = log(x) ~ cell.line + cell.line:treatment + compartment:cell.line + compartment:treatment + compartment:cell.line:treatment) Intercept corresponds to cell.line=EFO-27, treatment=N, compartment=intra _________________________________________________________________________ *** let7a $ConfidenceIntervals est LL UL p.value (Intercept) 8.06 3.22 20.18 0.000 cell.lineOAW-42 0.36 0.10 1.32 0.127 cell.lineSK-OV-3 0.38 0.10 1.39 0.148 cell.lineEFO-27:treatmentAc 1.20 0.33 4.41 0.780 cell.lineOAW-42:treatmentAc 0.99 0.25 3.94 0.993 cell.lineSK-OV-3:treatmentAc 1.02 0.28 3.75 0.974 cell.lineEFO-27:treatmentHx 0.86 0.23 3.14 0.817 cell.lineOAW-42:treatmentHx 0.99 0.27 3.63 0.988 cell.lineSK-OV-3:treatmentHx 1.00 0.27 3.66 0.997 cell.lineEFO-27:compartmentextra 0.11 0.03 0.40 0.001 cell.lineOAW-42:compartmentextra 0.26 0.07 0.97 0.048 cell.lineSK-OV-3:compartmentextra 0.83 0.23 3.03 0.775 treatmentAc:compartmentextra 0.84 0.13 5.28 0.854 treatmentHx:compartmentextra 1.51 0.24 9.49 0.660 cell.lineOAW-42:treatmentAc:compartmentextra 1.21 0.09 16.87 0.889 cell.lineSK-OV-3:treatmentAc:compartmentextra 0.74 0.06 9.97 0.823 cell.lineOAW-42:treatmentHx:compartmentextra 0.58 0.04 7.80 0.683 cell.lineSK-OV-3:treatmentHx:compartmentextra 0.54 0.04 7.25 0.644 *** let7d $ConfidenceIntervals est LL UL p.value (Intercept) 4.25 2.30 7.82 0.000 cell.lineOAW-42 0.40 0.17 0.95 0.041 cell.lineSK-OV-3 0.35 0.15 0.83 0.020 cell.lineEFO-27:treatmentAc 1.20 0.51 2.86 0.674 cell.lineOAW-42:treatmentAc 0.99 0.40 2.49 0.989 cell.lineSK-OV-3:treatmentAc 1.03 0.43 2.44 0.953 cell.lineEFO-27:treatmentHx 0.89 0.38 2.12 0.799 cell.lineOAW-42:treatmentHx 0.99 0.42 2.36 0.987 cell.lineSK-OV-3:treatmentHx 1.01 0.42 2.39 0.985 cell.lineEFO-27:compartmentextra 0.18 0.07 0.42 0.000 cell.lineOAW-42:compartmentextra 0.46 0.20 1.10 0.087 cell.lineSK-OV-3:compartmentextra 1.28 0.54 3.05 0.574 treatmentAc:compartmentextra 1.36 0.40 4.61 0.626 treatmentHx:compartmentextra 1.36 0.40 4.63 0.621 cell.lineOAW-42:treatmentAc:compartmentextra 0.77 0.13 4.47 0.774 cell.lineSK-OV-3:treatmentAc:compartmentextra 0.47 0.08 2.66 0.398 cell.lineOAW-42:treatmentHx:compartmentextra 0.98 0.17 5.55 0.985 cell.lineSK-OV-3:treatmentHx:compartmentextra 0.44 0.08 2.50 0.359 *** miR.10a $ConfidenceIntervals est LL UL p.value (Intercept) 0.99 0.23 4.28 0.985 cell.lineOAW-42 0.06 0.01 0.44 0.008 cell.lineSK-OV-3 0.18 0.02 1.40 0.105 cell.lineEFO-27:treatmentAc 1.20 0.15 9.60 0.861 cell.lineOAW-42:treatmentAc 0.83 0.09 7.46 0.865 cell.lineSK-OV-3:treatmentAc 1.08 0.14 8.61 0.942 cell.lineEFO-27:treatmentHx 0.88 0.11 7.03 0.906 cell.lineOAW-42:treatmentHx 0.85 0.09 7.64 0.882 cell.lineSK-OV-3:treatmentHx 0.96 0.12 7.68 0.973 cell.lineEFO-27:compartmentextra 0.70 0.09 5.61 0.741 cell.lineOAW-42:compartmentextra 4.20 0.46 37.92 0.206 cell.lineSK-OV-3:compartmentextra 3.33 0.42 26.49 0.260 treatmentAc:compartmentextra 1.11 0.06 20.92 0.944 treatmentHx:compartmentextra 1.28 0.06 26.31 0.874 cell.lineOAW-42:treatmentAc:compartmentextra 2.82 0.04 216.32 0.641 cell.lineSK-OV-3:treatmentAc:compartmentextra 0.39 0.01 24.50 0.655 cell.lineOAW-42:treatmentHx:compartmentextra 1.07 0.01 81.86 0.977 cell.lineSK-OV-3:treatmentHx:compartmentextra 0.73 0.01 49.08 0.882 *** miR.15a $ConfidenceIntervals est LL UL p.value (Intercept) 0.26 0.03 2.00 0.198 cell.lineOAW-42 0.72 0.04 13.13 0.822 cell.lineSK-OV-3 0.49 0.03 8.99 0.632 cell.lineEFO-27:treatmentAc 1.07 0.05 23.34 0.967 cell.lineOAW-42:treatmentAc 1.51 0.07 32.98 0.795 cell.lineSK-OV-3:treatmentAc 0.92 0.05 16.80 0.953 cell.lineEFO-27:treatmentHx 1.08 0.06 19.89 0.956 cell.lineOAW-42:treatmentHx 1.05 0.06 19.27 0.973 cell.lineSK-OV-3:treatmentHx 0.95 0.05 17.42 0.973 cell.lineEFO-27:compartmentextra 428.64 23.38 7859.65 0.000 cell.lineOAW-42:compartmentextra 438.58 23.92 8041.82 0.000 cell.lineSK-OV-3:compartmentextra 536.59 29.26 9838.90 0.000 treatmentAc:compartmentextra 1.07 0.02 73.99 0.977 treatmentHx:compartmentextra 0.51 0.01 31.24 0.750 cell.lineOAW-42:treatmentAc:compartmentextra 0.16 0.00 63.34 0.548 cell.lineSK-OV-3:treatmentAc:compartmentextra 0.54 0.00 197.82 0.837 cell.lineOAW-42:treatmentHx:compartmentextra 4.63 0.01 1556.21 0.607 cell.lineSK-OV-3:treatmentHx:compartmentextra 1.08 0.00 364.76 0.978 *** miR.15b $ConfidenceIntervals est LL UL p.value (Intercept) 3.91 2.30 6.65 0.000 cell.lineOAW-42 0.77 0.36 1.62 0.489 cell.lineSK-OV-3 0.58 0.27 1.23 0.157 cell.lineEFO-27:treatmentAc 1.11 0.52 2.35 0.789 cell.lineOAW-42:treatmentAc 0.97 0.44 2.15 0.936 cell.lineSK-OV-3:treatmentAc 0.98 0.46 2.07 0.953 cell.lineEFO-27:treatmentHx 1.04 0.49 2.20 0.920 cell.lineOAW-42:treatmentHx 1.09 0.52 2.32 0.818 cell.lineSK-OV-3:treatmentHx 0.99 0.46 2.09 0.969 cell.lineEFO-27:compartmentextra 0.48 0.23 1.02 0.060 cell.lineOAW-42:compartmentextra 0.68 0.32 1.44 0.314 cell.lineSK-OV-3:compartmentextra 1.21 0.57 2.56 0.622 treatmentAc:compartmentextra 1.60 0.55 4.63 0.388 treatmentHx:compartmentextra 0.99 0.34 2.86 0.982 cell.lineOAW-42:treatmentAc:compartmentextra 0.60 0.13 2.76 0.514 cell.lineSK-OV-3:treatmentAc:compartmentextra 0.39 0.09 1.77 0.228 cell.lineOAW-42:treatmentHx:compartmentextra 1.44 0.32 6.46 0.637 cell.lineSK-OV-3:treatmentHx:compartmentextra 0.67 0.15 3.02 0.605 *** miR.19b $ConfidenceIntervals est LL UL p.value (Intercept) 0.21 0.09 0.50 0.001 cell.lineOAW-42 1.01 0.30 3.36 0.986 cell.lineSK-OV-3 1.01 0.30 3.34 0.990 cell.lineEFO-27:treatmentAc 1.18 0.33 4.21 0.800 cell.lineOAW-42:treatmentAc 0.94 0.26 3.34 0.918 cell.lineSK-OV-3:treatmentAc 0.83 0.23 2.97 0.779 cell.lineEFO-27:treatmentHx 1.19 0.36 3.93 0.782 cell.lineOAW-42:treatmentHx 0.59 0.17 2.12 0.424 cell.lineSK-OV-3:treatmentHx 1.16 0.35 3.86 0.807 cell.lineEFO-27:compartmentextra 3.15 0.95 10.44 0.065 cell.lineOAW-42:compartmentextra 2.07 0.62 6.86 0.240 cell.lineSK-OV-3:compartmentextra 2.15 0.65 7.15 0.214 treatmentAc:compartmentextra 0.77 0.13 4.45 0.775 treatmentHx:compartmentextra 0.49 0.09 2.70 0.419 cell.lineOAW-42:treatmentAc:compartmentextra 2.86 0.24 33.93 0.408 cell.lineSK-OV-3:treatmentAc:compartmentextra 2.81 0.24 33.28 0.416 cell.lineOAW-42:treatmentHx:compartmentextra 6.81 0.60 77.90 0.127 cell.lineSK-OV-3:treatmentHx:compartmentextra 4.97 0.45 54.77 0.195 *** miR.20a $ConfidenceIntervals est LL UL p.value (Intercept) 0.47 0.23 0.97 0.043 cell.lineOAW-42 0.80 0.29 2.20 0.662 cell.lineSK-OV-3 1.20 0.44 3.32 0.722 cell.lineEFO-27:treatmentAc 1.72 0.62 4.73 0.301 cell.lineOAW-42:treatmentAc 1.32 0.45 3.88 0.612 cell.lineSK-OV-3:treatmentAc 1.00 0.34 2.95 0.994 cell.lineEFO-27:treatmentHx 1.20 0.44 3.32 0.723 cell.lineOAW-42:treatmentHx 1.25 0.45 3.45 0.666 cell.lineSK-OV-3:treatmentHx 1.26 0.46 3.49 0.652 cell.lineEFO-27:compartmentextra 3.73 1.35 10.28 0.013 cell.lineOAW-42:compartmentextra 5.74 2.08 15.83 0.001 cell.lineSK-OV-3:compartmentextra 5.08 1.84 14.00 0.002 treatmentAc:compartmentextra 1.05 0.25 4.42 0.945 treatmentHx:compartmentextra 0.79 0.19 3.31 0.747 cell.lineOAW-42:treatmentAc:compartmentextra 1.21 0.15 9.49 0.858 cell.lineSK-OV-3:treatmentAc:compartmentextra 0.83 0.11 6.52 0.861 cell.lineOAW-42:treatmentHx:compartmentextra 1.33 0.17 10.10 0.785 cell.lineSK-OV-3:treatmentHx:compartmentextra 0.67 0.09 5.10 0.700 *** miR.21 $ConfidenceIntervals est LL UL p.value (Intercept) 21.55 4.51 103.06 0.000 cell.lineOAW-42 0.65 0.07 5.95 0.705 cell.lineSK-OV-3 0.25 0.03 2.25 0.219 cell.lineEFO-27:treatmentAc 0.78 0.07 8.18 0.838 cell.lineOAW-42:treatmentAc 1.45 0.14 15.15 0.758 cell.lineSK-OV-3:treatmentAc 1.31 0.14 11.99 0.811 cell.lineEFO-27:treatmentHx 1.11 0.12 10.18 0.924 cell.lineOAW-42:treatmentHx 0.63 0.07 5.80 0.688 cell.lineSK-OV-3:treatmentHx 1.12 0.12 10.25 0.920 cell.lineEFO-27:compartmentextra 0.31 0.03 2.86 0.308 cell.lineOAW-42:compartmentextra 0.50 0.05 4.56 0.540 cell.lineSK-OV-3:compartmentextra 0.38 0.04 3.99 0.423 treatmentAc:compartmentextra 1.91 0.08 48.09 0.695 treatmentHx:compartmentextra 1.49 0.07 34.09 0.803 cell.lineOAW-42:treatmentAc:compartmentextra 1.35 0.01 129.47 0.897 cell.lineSK-OV-3:treatmentAc:compartmentextra 1.43 0.01 137.29 0.877 cell.lineOAW-42:treatmentHx:compartmentextra 2.37 0.03 197.76 0.704 cell.lineSK-OV-3:treatmentHx:compartmentextra 3.00 0.03 268.45 0.633 *** miR.100 $ConfidenceIntervals est LL UL p.value (Intercept) 0.08 0.03 0.25 0.000 cell.lineOAW-42 3.20 0.68 15.20 0.148 cell.lineSK-OV-3 10.29 2.17 48.83 0.005 cell.lineEFO-27:treatmentAc 1.07 0.20 5.57 0.938 cell.lineOAW-42:treatmentAc 1.07 0.21 5.58 0.937 cell.lineSK-OV-3:treatmentAc 0.95 0.20 4.51 0.948 cell.lineEFO-27:treatmentHx 0.87 0.18 4.14 0.863 cell.lineOAW-42:treatmentHx 0.97 0.21 4.62 0.973 cell.lineSK-OV-3:treatmentHx 0.96 0.20 4.56 0.960 cell.lineEFO-27:compartmentextra 0.40 0.08 1.90 0.252 cell.lineOAW-42:compartmentextra 0.51 0.10 2.64 0.423 cell.lineSK-OV-3:compartmentextra 0.48 0.10 2.27 0.358 treatmentAc:compartmentextra 0.59 0.06 6.09 0.659 treatmentHx:compartmentextra 0.95 0.10 9.18 0.964 cell.lineOAW-42:treatmentAc:compartmentextra 2.31 0.08 62.83 0.621 cell.lineSK-OV-3:treatmentAc:compartmentextra 3.06 0.12 79.56 0.503 cell.lineOAW-42:treatmentHx:compartmentextra 2.03 0.08 52.74 0.671 cell.lineSK-OV-3:treatmentHx:compartmentextra 3.22 0.13 79.75 0.478 *** miR.125b $ConfidenceIntervals est LL UL p.value (Intercept) 0.01 0.00 0.06 0.000 cell.lineOAW-42 95.99 14.66 628.61 0.000 cell.lineSK-OV-3 70.14 10.71 459.31 0.000 cell.lineEFO-27:treatmentAc 0.76 0.07 7.99 0.822 cell.lineOAW-42:treatmentAc 1.01 0.18 5.65 0.995 cell.lineSK-OV-3:treatmentAc 0.96 0.19 4.88 0.960 cell.lineEFO-27:treatmentHx 0.65 0.08 5.30 0.687 cell.lineOAW-42:treatmentHx 0.26 0.05 1.32 0.109 cell.lineSK-OV-3:treatmentHx 0.93 0.18 4.76 0.935 cell.lineEFO-27:compartmentextra 6.05 0.92 39.61 0.065 cell.lineOAW-42:compartmentextra 1.28 0.20 8.41 0.795 cell.lineSK-OV-3:compartmentextra 0.47 0.09 2.38 0.365 treatmentAc:compartmentextra 0.48 0.03 8.86 0.624 treatmentHx:compartmentextra 0.57 0.04 8.18 0.683 cell.lineOAW-42:treatmentAc:compartmentextra 2.79 0.06 140.22 0.609 cell.lineSK-OV-3:treatmentAc:compartmentextra 2.42 0.06 99.44 0.642 cell.lineOAW-42:treatmentHx:compartmentextra 2.61 0.07 99.16 0.608 cell.lineSK-OV-3:treatmentHx:compartmentextra 3.55 0.11 119.51 0.483 *** miR.155 No result due to missing data *** miR.222 $ConfidenceIntervals est LL UL p.value (Intercept) 2.64 1.14 6.11 0.027 cell.lineOAW-42 0.61 0.19 2.00 0.416 cell.lineSK-OV-3 0.16 0.05 0.53 0.004 cell.lineEFO-27:treatmentAc 1.07 0.30 3.76 0.921 cell.lineOAW-42:treatmentAc 0.97 0.28 3.43 0.964 cell.lineSK-OV-3:treatmentAc 1.12 0.34 3.67 0.856 cell.lineEFO-27:treatmentHx 0.97 0.29 3.17 0.954 cell.lineOAW-42:treatmentHx 1.13 0.34 3.71 0.840 cell.lineSK-OV-3:treatmentHx 1.05 0.32 3.44 0.940 cell.lineEFO-27:compartmentextra 0.12 0.03 0.42 0.002 cell.lineOAW-42:compartmentextra 0.14 0.04 0.48 0.003 cell.lineSK-OV-3:compartmentextra 0.36 0.11 1.18 0.097 treatmentAc:compartmentextra 1.47 0.22 9.91 0.695 treatmentHx:compartmentextra 0.58 0.10 3.28 0.540 cell.lineOAW-42:treatmentAc:compartmentextra 0.45 0.03 6.11 0.549 cell.lineSK-OV-3:treatmentAc:compartmentextra 0.84 0.07 10.69 0.893 cell.lineOAW-42:treatmentHx:compartmentextra 2.10 0.18 24.39 0.554 cell.lineSK-OV-3:treatmentHx:compartmentextra 3.24 0.29 36.23 0.343