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{"sheet":"Supplementary Table 6","index":0,"n_rows":79,"n_cols":7,"rows_kept":79,"merged":[[78,0,78,4]],"flags":["formulas_cached_only"]}
["ID","Description","GeneRatio","BgRatio","pvalue","p.adjust","geneID"]
["GO:0060070","canonical Wnt signaling pathway","18/133","222/9213",2.57929966747095e-09,7.08275688687523e-06,"WNT6/MAD2L2/PIN1/LRP6/NKD1/WNT9A/FZD7/FZD1/WNT1/NKD2/DVL3/KREMEN1/RSPO1/RSPO3/FZD6/WNT2B/DAAM2/WNT8A"]
["GO:0016055","Wnt signaling pathway","19/133","318/9213",1.3161755782520598e-07,0.00010391854948088701,"WNT6/MAD2L2/PIN1/LRP6/NKD1/WNT9A/FZD7/WIF1/FZD1/WNT1/NKD2/DVL3/KREMEN1/RSPO1/RSPO3/FZD6/WNT2B/DAAM2/WNT8A"]
["GO:0198738","cell-cell signaling by wnt","19/133","320/9213",1.4523224674716899e-07,0.00010391854948088701,"WNT6/MAD2L2/PIN1/LRP6/NKD1/WNT9A/FZD7/WIF1/FZD1/WNT1/NKD2/DVL3/KREMEN1/RSPO1/RSPO3/FZD6/WNT2B/DAAM2/WNT8A"]
["GO:1905114","cell surface receptor signaling pathway involved in cell-cell signaling","21/133","389/9213",1.51374434786434e-07,0.00010391854948088701,"STX1A/WNT6/MAD2L2/PIN1/LRP6/NKD1/WNT9A/FZD7/WIF1/FZD1/WNT1/NKD2/DVL3/MAPK8IP2/KREMEN1/RSPO1/RSPO3/FZD6/WNT2B/DAAM2/WNT8A"]
["GO:0006470","protein dephosphorylation","14/133","216/9213",2.59322436800541e-06,0.00142419882290857,"PPP2CB/PPP3R1/PIN1/PPP1R1B/CAMK2G/PPP2R2A/PPP4R2/PPP1R15B/YWHAB/PPP1CB/FKBP1A/PPP4R1/NCK1/DUSP7"]
["GO:0031396","regulation of protein ubiquitination","12/133","164/9213",4.03453394950239e-06,0.0016883480869437702,"MAD2L2/NMI/PIN1/PRKCE/CDC20/UBE2D1/DAXX/SPRY2/FZR1/FKBP1A/DCUN1D2/ANGPT1"]
["GO:0018105","peptidyl-serine phosphorylation","15/133","258/9213",4.303873491844999e-06,0.0016883480869437702,"MAD2L2/AKT3/BRAF/TDGF1/PRKCE/MAPK7/CDK5R1/MLXIPL/MAPKAPK2/SPRY2/TCL1A/NCK1/RPS6KA2/NOS1/ANGPT1"]
["GO:0016311","dephosphorylation","16/133","303/9213",6.96937581836304e-06,0.0023856656436299904,"PPP2CB/PPP3R1/PIN1/PPP1R1B/CAMK2G/PPP2R2A/PPP1R17/PPP4R2/PFKFB2/PPP1R15B/YWHAB/PPP1CB/FKBP1A/PPP4R1/NCK1/DUSP7"]
["GO:0018209","peptidyl-serine modification","15/133","272/9213",8.18762411045023e-06,0.0023856656436299904,"MAD2L2/AKT3/BRAF/TDGF1/PRKCE/MAPK7/CDK5R1/MLXIPL/MAPKAPK2/SPRY2/TCL1A/NCK1/RPS6KA2/NOS1/ANGPT1"]
["GO:0035567","non-canonical Wnt signaling pathway","7/133","52/9213",8.68778457257825e-06,0.0023856656436299904,"NKD1/FZD7/FZD1/DVL3/RSPO3/FZD6/DAAM2"]
["GO:0070935","3'-UTR-mediated mRNA stabilization","4/133","12/9213",1.8785471296816803e-05,0.00438019644841854,"HNRNPA0/MAPKAPK2/ELAVL1/HNRNPC"]
["GO:1903320","regulation of protein modification by small protein conjugation or removal","12/133","191/9213",1.91569776959553e-05,0.00438019644841854,"MAD2L2/NMI/PIN1/PRKCE/CDC20/UBE2D1/DAXX/SPRY2/FZR1/FKBP1A/DCUN1D2/ANGPT1"]
["GO:0060071","Wnt signaling pathway, planar cell polarity pathway","6/133","40/9213",2.07365454586457e-05,0.00438019644841854,"NKD1/FZD7/FZD1/DVL3/RSPO3/FZD6"]
["GO:0090175","regulation of establishment of planar polarity","6/133","41/9213",2.40057946085496e-05,0.0047085651425055105,"NKD1/FZD7/FZD1/DVL3/RSPO3/FZD6"]
["GO:0090101","negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway","8/133","84/9213",2.65034625218934e-05,0.00485190053900795,"PIN1/FZD1/WNT1/DAND5/UBE2D1/SPRY2/CER1/FKBP1A"]
["GO:0009798","axis specification","7/133","63/9213",3.14917952234942e-05,0.00540477935523219,"WNT6/TDRD1/WNT1/TDGF1/ETS2/CER1/WNT8A"]
["GO:0009792","embryo development ending in birth or egg hatching","19/133","477/9213",5.0904260535712e-05,0.008222535260650891,"LRP6/COPS3/WNT9A/FZD1/CCNB2/WNT1/TDGF1/PLG/DVL3/CDK5R1/RSPO3/FZD6/RRM2/EIF2S2/NKX3-1/GRB2/PRMT1/WNT8A/ANGPT1"]
["GO:0060828","regulation of canonical Wnt signaling pathway","11/133","180/9213",5.568871114340691e-05,0.0084956222666553,"MAD2L2/PIN1/NKD1/FZD7/FZD1/NKD2/KREMEN1/RSPO1/RSPO3/FZD6/DAAM2"]
["GO:0031398","positive regulation of protein ubiquitination","8/133","95/9213",6.470542740777361e-05,0.00935163703482875,"NMI/PIN1/CDC20/UBE2D1/FZR1/FKBP1A/DCUN1D2/ANGPT1"]
["GO:0001763","morphogenesis of a branching structure","10/133","158/9213",9.156042779792561e-05,0.0125712467366552,"WNT6/WNT1/TDGF1/RSPO3/EPHA7/WNT2B/ENG/SPRY2/NKX3-1/GRB2"]
["GO:0030111","regulation of Wnt signaling pathway","12/133","226/9213",9.937204606301932e-05,0.012696098493797001,"MAD2L2/PIN1/NKD1/FZD7/WIF1/FZD1/NKD2/KREMEN1/RSPO1/RSPO3/FZD6/DAAM2"]
["GO:0001736","establishment of planar polarity","6/133","53/9213",0.00010636923992059801,0.012696098493797001,"NKD1/FZD7/FZD1/DVL3/RSPO3/FZD6"]
["GO:0007164","establishment of tissue polarity","6/133","53/9213",0.00010636923992059801,0.012696098493797001,"NKD1/FZD7/FZD1/DVL3/RSPO3/FZD6"]
["GO:0031400","negative regulation of protein modification process","16/133","381/9213",0.00011394651659279301,0.012696098493797001,"GADD45B/MAD2L2/PPP1R1B/LRP6/PRKCE/MLXIPL/PPP4R2/PPP1R15B/CDC20/YWHAB/ENG/SPRY2/FKBP1A/NCK1/DUSP7/ANGPT1"]
["GO:0009948","anterior/posterior axis specification","5/133","34/9213",0.000115587204058604,0.012696098493797001,"TDRD1/TDGF1/ETS2/CER1/WNT8A"]
["GO:0048598","embryonic morphogenesis","17/133","424/9213",0.00012104318208761701,0.0127840222312537,"MAP2K5/WNT6/MMP8/FZD7/FZD1/WNT1/MAPK7/DVL3/RSPO3/FZD6/ETS2/WNT2B/ENG/SPRY2/CER1/TH/GRB2"]
["GO:0070262","peptidyl-serine dephosphorylation","4/133","19/9213",0.00013598391231127102,0.0136809258397145,"PPP2CB/PPP2R2A/PPP1R15B/NCK1"]
["GO:0007507","heart development","17/133","429/9213",0.000139499607979609,0.0136809258397145,"MAP2K5/MYL7/SLC9A1/FZD7/FZD1/TDGF1/DAND5/ENG/TNFRSF1B/NKX3-1/CER1/TH/MYH11/FKBP1A/PRMT1/RPS6KA2/WNT8A"]
["GO:0048255","mRNA stabilization","5/133","36/9213",0.000153021870376389,0.0144895881397781,"HNRNPA0/E2F1/MAPKAPK2/ELAVL1/HNRNPC"]
["GO:0009952","anterior/posterior pattern specification","9/133","140/9213",0.000184365034287755,0.016185159584704,"TDRD1/LRP6/WNT1/TDGF1/ETS2/WNT2B/NKX3-1/CER1/WNT8A"]
["GO:1903322","positive regulation of protein modification by small protein conjugation or removal","8/133","111/9213",0.00019379504437573,0.016185159584704,"NMI/PIN1/CDC20/UBE2D1/FZR1/FKBP1A/DCUN1D2/ANGPT1"]
["GO:0080135","regulation of cellular response to stress","18/133","484/9213",0.00019438968978304402,0.016185159584704,"GADD45B/MAD2L2/MMP8/COPS3/FZD7/FZD1/WNT1/MAPK7/MAPK8IP2/KREMEN1/PPP4R2/MAPKAPK2/PPP1R15B/RPA2/NKX3-1/INS/PRMT1/NCK1"]
["GO:1901019","regulation of calcium ion transmembrane transporter activity","6/133","59/9213",0.00019450483113446103,0.016185159584704,"SLC9A1/CACNB3/STAC3/HSPA2/FKBP1A/NOS1"]
["GO:0022898","regulation of transmembrane transporter activity","10/133","176/9213",0.00022293757392672202,0.017717926092815,"SLC9A1/CACNA1D/CACNB3/PRKCE/STAC3/MAPK8IP2/HSPA2/INS/FKBP1A/NOS1"]
["GO:0045936","negative regulation of phosphate metabolic process","14/133","323/9213",0.00022582935660907602,0.017717926092815,"GADD45B/PPP1R1B/LRP6/MLXIPL/PPP4R2/PPP1R15B/YWHAB/ENG/IRS2/SPRY2/FKBP1A/NCK1/DUSP7/ANGPT1"]
["GO:0010563","negative regulation of phosphorus metabolic process","14/133","324/9213",0.00023315172060313903,0.0177842951326727,"GADD45B/PPP1R1B/LRP6/MLXIPL/PPP4R2/PPP1R15B/YWHAB/ENG/IRS2/SPRY2/FKBP1A/NCK1/DUSP7/ANGPT1"]
["GO:0051347","positive regulation of transferase activity","17/133","449/9213",0.000240370062011043,0.0178393564941168,"MAP2K5/PIN1/TDGF1/DVL3/CDK5R1/IL23R/HNRNPA2B1/PFKFB2/EPHA7/CDC20/DAXX/SPRY2/FZR1/INS/TCL1A/DCUN1D2/ANGPT1"]
["GO:0030514","negative regulation of BMP signaling pathway","5/133","40/9213",0.000255024220865433,0.018428855539381003,"FZD1/WNT1/DAND5/UBE2D1/CER1"]
["GO:0051924","regulation of calcium ion transport","10/133","180/9213",0.000267416584105657,0.0187402482436267,"SLC9A1/CACNA1D/CACNB3/PRKCE/CAMK2G/STAC3/MYLK/HSPA2/FKBP1A/NOS1"]
["GO:0033135","regulation of peptidyl-serine phosphorylation","8/133","117/9213",0.00027844060947724203,0.0187402482436267,"MAD2L2/BRAF/MLXIPL/SPRY2/TCL1A/NCK1/NOS1/ANGPT1"]
["GO:1903312","negative regulation of mRNA metabolic process","6/133","63/9213",0.000279807056805788,0.0187402482436267,"HNRNPA0/E2F1/HNRNPA2B1/MAPKAPK2/ELAVL1/HNRNPC"]
["GO:0043489","RNA stabilization","5/133","41/9213",0.000287110113401111,0.0187715326523679,"HNRNPA0/E2F1/MAPKAPK2/ELAVL1/HNRNPC"]
["GO:2000027","regulation of animal organ morphogenesis","7/133","90/9213",0.000307962879428015,0.0196666527188216,"NKD1/FZD7/FZD1/DVL3/RSPO3/FZD6/WNT2B"]
["GO:1902373","negative regulation of mRNA catabolic process","5/133","42/9213",0.00032216856773274104,0.0201062474316842,"HNRNPA0/E2F1/MAPKAPK2/ELAVL1/HNRNPC"]
["GO:0032409","regulation of transporter activity","10/133","188/9213",0.00037890917059493404,0.0223457786481525,"SLC9A1/CACNA1D/CACNB3/PRKCE/STAC3/MAPK8IP2/HSPA2/INS/FKBP1A/NOS1"]
["GO:0043009","chordate embryonic development","17/133","467/9213",0.000380593329604418,0.0223457786481525,"LRP6/COPS3/WNT9A/FZD1/CCNB2/WNT1/PLG/DVL3/RSPO3/FZD6/RRM2/EIF2S2/NKX3-1/GRB2/PRMT1/WNT8A/ANGPT1"]
["GO:0007389","pattern specification process","13/133","300/9213",0.00038246598560202704,0.0223457786481525,"WNT6/TDRD1/LRP6/WNT1/TDGF1/DAND5/ETS2/WNT2B/ENG/NKX3-1/CER1/DAAM2/WNT8A"]
["GO:1904953","Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation","3/133","11/9213",0.000445886556336682,0.025508426743761,"LRP6/FZD1/WNT1"]
["GO:0001738","morphogenesis of a polarized epithelium","6/133","69/9213",0.00046000987821047504,0.025779329093183003,"NKD1/FZD7/FZD1/DVL3/RSPO3/FZD6"]
["GO:0070979","protein K11-linked ubiquitination","4/133","26/9213",0.00048498527140279505,0.0266353911054415,"ANAPC11/CDC26/CDC23/FZR1"]
["GO:0048013","ephrin receptor signaling pathway","5/133","46/9213",0.000495729965886732,0.026691656594607198,"NGEF/CDK5R1/EPHA7/NCK1/YES1"]
["GO:0051783","regulation of nuclear division","8/133","128/9213",0.000511376498558855,0.0270046127892811,"MAD2L2/PIN1/ANAPC11/CDC20/CDC23/FZR1/INS/RPS6KA2"]
["GO:0090288","negative regulation of cellular response to growth factor stimulus","6/133","72/9213",0.0005787600367105281,0.0299863219020209,"FZD1/WNT1/DAND5/UBE2D1/SPRY2/CER1"]
["GO:0051443","positive regulation of ubiquitin-protein transferase activity","4/133","28/9213",0.000649546710218829,0.0330306530789056,"PIN1/CDC20/FZR1/DCUN1D2"]
["GO:0007346","regulation of mitotic cell cycle","14/133","361/9213",0.000693267611833602,0.0338806995787395,"RPA3/MAD2L2/PIN1/E2F1/ANAPC11/RRM2/RPA2/CDC26/NKX3-1/HSPA2/CDC23/FZR1/INS/EIF4E"]
["GO:0030510","regulation of BMP signaling pathway","6/133","75/9213",0.000720063390348149,0.0338806995787395,"FZD1/WNT1/DAND5/ENG/UBE2D1/CER1"]
["GO:0051438","regulation of ubiquitin-protein transferase activity","5/133","50/9213",0.000731733387059706,0.0338806995787395,"MAD2L2/PIN1/CDC20/FZR1/DCUN1D2"]
["GO:1902369","negative regulation of RNA catabolic process","5/133","50/9213",0.000731733387059706,0.0338806995787395,"HNRNPA0/E2F1/MAPKAPK2/ELAVL1/HNRNPC"]
["GO:0032412","regulation of ion transmembrane transporter activity","9/133","169/9213",0.0007393298066143121,0.0338806995787395,"SLC9A1/CACNA1D/CACNB3/PRKCE/STAC3/MAPK8IP2/HSPA2/FKBP1A/NOS1"]
["GO:1901021","positive regulation of calcium ion transmembrane transporter activity","4/133","29/9213",0.000745111020318595,0.0338806995787395,"SLC9A1/CACNB3/STAC3/HSPA2"]
["GO:0038092","nodal signaling pathway","3/133","13/9213",0.0007566802314563331,0.0338806995787395,"TDGF1/DAND5/CER1"]
["GO:0048729","tissue morphogenesis","16/133","452/9213",0.0007727378917024771,0.0338806995787395,"WNT6/NKD1/FZD7/FZD1/WNT1/DVL3/RSPO3/FZD6/MYLK/EPHA7/WNT2B/ENG/SPRY2/NKX3-1/GRB2/FKBP1A"]
["GO:0042326","negative regulation of phosphorylation","12/133","283/9213",0.000781317559247172,0.0338806995787395,"GADD45B/PPP1R1B/LRP6/MLXIPL/PPP4R2/PPP1R15B/ENG/IRS2/SPRY2/NCK1/DUSP7/ANGPT1"]
["GO:0030512","negative regulation of transforming growth factor beta receptor signaling pathway","5/133","51/9213",0.0008019830563066521,0.0338806995787395,"PIN1/WNT1/DAND5/SPRY2/FKBP1A"]
["GO:0071300","cellular response to retinoic acid","5/133","51/9213",0.0008019830563066521,0.0338806995787395,"WNT6/SERPINF1/WNT9A/FZD7/YES1"]
["GO:1903169","regulation of calcium ion transmembrane transport","7/133","106/9213",0.000830128371611937,0.0345383713400967,"SLC9A1/CACNB3/PRKCE/STAC3/HSPA2/FKBP1A/NOS1"]
["GO:0002009","morphogenesis of an epithelium","14/133","373/9213",0.0009537235972720581,0.0390884328075981,"WNT6/NKD1/FZD7/FZD1/WNT1/DVL3/RSPO3/FZD6/EPHA7/WNT2B/ENG/SPRY2/NKX3-1/GRB2"]
["GO:0042770","signal transduction in response to DNA damage","8/133","142/9213",0.0010139448244948302,0.0407762908258374,"MAD2L2/COPS3/WNT1/SP100/E2F1/RPA2/GRB2/FZR1"]
["GO:0001933","negative regulation of protein phosphorylation","11/133","252/9213",0.001024604540052,0.0407762908258374,"GADD45B/PPP1R1B/LRP6/MLXIPL/PPP4R2/PPP1R15B/ENG/SPRY2/NCK1/DUSP7/ANGPT1"]
["GO:0042772","DNA damage response, signal transduction resulting in transcription","3/133","15/9213",0.0011786250122782,0.045584567376281006,"MAD2L2/COPS3/SP100"]
["GO:1904948","midbrain dopaminergic neuron differentiation","3/133","15/9213",0.0011786250122782,0.045584567376281006,"LRP6/FZD1/WNT1"]
["GO:0000723","telomere maintenance","7/133","113/9213",0.00121042459445846,0.0459890718061914,"RPA3/RPA1/CCT7/SP100/HNRNPA2B1/RPA2/HNRNPC"]
["GO:0007169","transmembrane receptor protein tyrosine kinase signaling pathway","16/133","472/9213",0.0012225791121092402,0.0459890718061914,"NGEF/BRAF/WNT1/CDK5R1/JAK1/MAPKAPK2/EPHA7/EIF4EBP2/IRS2/SPRY2/NKX3-1/GRB2/INS/NCK1/YES1/ANGPT1"]
["GO:0061138","morphogenesis of a branching epithelium","8/133","147/9213",0.00126820895961001,0.0470608351768795,"WNT6/WNT1/RSPO3/WNT2B/ENG/SPRY2/NKX3-1/GRB2"]
["GO:0032526","response to retinoic acid","6/133","84/9213",0.0013078691615090801,0.0478854495667191,"WNT6/SERPINF1/WNT9A/FZD7/YES1/WNT8A"]
[]
[]
["\nSupplementary Table 6 - Top-associated Gene Ontology Biological Process Terms after enrichment analysis of genes which are part of the detected network module. Terms associated at p.adjust<0.05 are reported. \nGeneRatio: number of genes in the module annotated to the Term/number of genes in the module\t\nBgRatio: number of genes annotated to the Term/number of genes in background universe\t\npvalue: pvalue from over-representation analysis\np.adjust: adjusted p-value after application of Benjamini-Hochberg procedure\ngeneID: gene symbols for genes in the module annotated to the Term\n"]