1Differentiation, WHO classification, whole tumor
1 = Well
2 = Moderate
3 = Poor

3Degree of keratinization, whole tumor:
1 = Highly keratinized (>50 % of tumor areal)
2 = Moderately keratinized (20-50% of tumor areal)
3 = Minimal keratinisation (5-20% of tumor areal)
4 = No keratinisation (0-5 % of tumor areal)

4Degree of keratinization, within the lowest differentiated parts of the most invasive 2-3 cell layers at the advancing front of tumors (Bryne et al 1998):
1 = Highly keratinized (>50 % of the cells)
2 = Moderately keratinized (20-50% of the cells)
3 = Minimal keratinisation (5-20% of the cells)
4 = No keratinisation (0-5 % of the cells)
5 = Not evaluable
9 = Missing/ not evaluable

5Nuclear polymorphism, whole tumor:
1 = Little nuclear polymorphism (in less than 25% of the cells)
2 = Moderately abundant nuclear polymorphism (in 25-50% of the cells)
3 = Abundant nuclear polymorphism (in 50-75% of the cells)
4 = Extreme nuclear polymorphism (in 75-100% of cells)

6Nuclear polymorphism, within the lowest differentiated parts of the most invasive 2-3 cell layers at the advancing front of tumors (Bryne et al 1998):
1 = Little nuclear polymorphism (In less than 25% of the cells)
2 = Moderately abundant nuclear polymorphism (In 25-50% of the cells)
3 = Abundant nuclear polymorphism (In 50-75% of the cells)
4 = Extreme nuclear polymorphism (In 75-100% of the cells)
5 = Not evaluable
9 = Missing/ not evaluable

7Perineural infiltration
1 = None
2 = Nerves at invasive front
3 = Nerves in tumor center
4 = Not evaluable
9 = Missing/ not evaluable

8Lymfocytic infiltrate
1 = Marked
2 = Moderate
3 = Slight/none
4 = Not evaluable
9 = Missing/ not evaluable

9Worst pattern of invasion (WPOI) (Brandwein-Gensler 2005, 2012, POI 1-4 based on Bryne et al 1998)
0 = Not evaluable
1 = Pushing, well delineated infiltrating borders
2 = Infiltrating, solid cords, bands and/or strands
3 = Small grous of cords of infiltrating cells (n>15 cells)
4 = Marked and widespread celleular dissociation in small groups and/or in single cells (n<15 cells)
5 = Tumor satellites of any size with 1 mm or greater distance of intervening normal tissue (not fibrosis) at the tumor host
9 = Missing/ not evaluable

Category 1.1
1 = Lowgrade
2 = Highgrade

Category 7.1
1 = No
2 = Yes

Category 8.1
1 = Marked
2 = Not marked

Category 9.1
1 = Lowgrade
2 = Intermediate grade
3 = Highgrade

Category 8.2
1 = Abundant
2 = Little

0 = No lymph node metastases (cN0/pN0)
1 = Lymph node metastases (cN+/pN+)
9 = No information

1 = Male
2 = Female

Group of age
1 = <50 years
2 = 51-60
3 = 61-70
4 = 71-80
5 = >81

Speciment
1 = Biopsy
2 = Resection

2 = Well + marked
3 = well + moderate/moderate+marked
4 = Well+slight/moderate+moderate/poor+marked
5 = Moderate+slicght/poor + moderate
6 = Poor + slight

Histo-score 2-4 versus 5-6
0 = Histo-score 2-4
1 = Histo-score 5-6

Low versus high stage
1 = Low-stage disease
2 = High-stage disease
9 = unknown

1 = Stage I
2 = Stage II
3 = Stage III
4 = Stage IV
5 = LK metastases, high grade without T status
9 = Unknown