Feature ID Fold change (YOUNGER_1 vs. OLDER_1) Fold change (YOUNGER_2 vs. OLDER_2) Fold change (YOUNGER_3 vs. OLDER_3) Fold change (YOUNGER_4 vs. OLDER_4) Fold change (YOUNGER_5 vs. OLDER_5) Fold change (YOUNGER_6 vs. OLDER_6) Fold change (YOUNGER_7 vs. OLDER_7) Fold change (YOUNGER_8 vs. OLDER_8) Fold change (YOUNGER_9 vs. OLDER_9) Fold change (YOUNGER_0 vs. OLDER_0) COLLECTIVE AVERAGE PTHLH -2.35E+00 -2.86E+00 -8.89E+00 -6.34E+00 -7.60E+00 -5.77E+00 2.23E+00 -2.34E+00 -3.21E+00 1.94E+00 -3.52E+01 -3.52E+00 PCSK6 -1.34E+00 -1.91E+00 -4.94E+00 -1.14E+00 -1.25E+00 -1.14E+00 -2.31E+00 -1.95E+00 -1.22E+00 -2.22E+00 -1.94E+01 -1.94E+00 ACE2 -2.63E+00 -2.18E+00 -1.83E+01 2.56E+00 3.29E+00 -2.42E+00 2.58E+00 -3.71E+00 -1.40E+00 5.99E+00 -1.62E+01 -1.62E+00 IGFBP5 -1.51E+00 1.32E+00 -4.89E+00 -1.34E+00 -1.49E+00 -1.95E+00 1.51E+00 -6.96E+00 -1.56E+00 1.10E+00 -1.58E+01 -1.58E+00 FER1L4 -2.43E+00 -1.65E+00 1.73E+00 -3.15E+00 -4.67E+00 2.81E+00 -1.22E+01 1.39E+01 3.48E+00 -1.26E+01 -1.48E+01 -1.48E+00 RHOBTB3 -1.64E+00 -1.48E+00 -6.05E+00 1.66E+00 -1.46E+00 -1.43E+00 1.54E+00 -3.59E+00 -2.19E+00 2.63E+00 -1.20E+01 -1.20E+00 THBS1 -1.78E+00 1.34E+00 -4.05E+00 -1.21E+00 -1.72E+00 1.19E+00 2.78E+00 -4.99E+00 -1.53E+00 -1.59E+00 -1.16E+01 -1.16E+00 CHGB -1.34E+00 -2.55E+00 -1.03E+01 3.15E+00 -2.33E+00 1.27E+00 2.03E+00 -2.53E+00 -1.98E+00 3.42E+00 -1.12E+01 -1.12E+00 NPTX2 -2.66E+00 2.07E+00 -3.68E+00 4.38E+00 -3.84E+00 1.62E+00 -1.24E+00 -3.29E+00 -2.52E+00 2.59E+00 -6.57E+00 -6.57E-01 GJA1 -1.41E+00 1.15E+00 -2.05E+00 1.26E+00 -1.71E+00 -1.38E+00 1.12E+00 -1.91E+00 -1.63E+00 1.57E+00 -4.99E+00 -4.99E-01 DUOX2 1.09E+00 1.37E+00 -2.07E+00 1.87E+00 1.26E+00 1.70E+00 -2.63E+00 -6.43E+00 -2.94E+00 2.04E+00 -4.74E+00 -4.74E-01 CSDC2 -1.21E+00 1.22E+00 1.72E+00 -3.34E+00 -1.59E+00 -1.27E+00 1.54E+00 2.18E+00 1.64E+00 -5.56E+00 -4.67E+00 -4.67E-01 DCBLD2 -1.62E+00 -1.40E+00 -1.25E+00 -1.23E+00 -1.45E+00 -2.14E+00 -1.68E+00 1.62E+00 2.71E+00 1.90E+00 -4.54E+00 -4.54E-01 COL6A3 -1.28E+00 1.18E+00 -1.60E+00 1.11E+00 1.51E+00 -1.15E+00 -1.21E+00 -3.05E+00 -1.59E+00 1.57E+00 -4.51E+00 -4.51E-01 IL6ST 1.27E+00 -1.12E+00 -1.15E+00 1.26E+00 -1.24E+00 -1.62E+00 1.19E+00 -1.77E+00 -2.56E+00 1.89E+00 -3.85E+00 -3.85E-01 PFKP -1.19E+00 1.33E+00 1.46E+00 -1.34E+00 1.56E+00 1.43E+00 -2.37E+00 -1.38E+00 -1.17E+00 -1.88E+00 -3.55E+00 -3.55E-01 COL4A1 -1.47E+00 -2.28E+00 -1.20E+00 -1.61E+00 1.67E+00 -1.94E+00 1.42E+00 1.75E+00 1.24E+00 -1.10E+00 -3.52E+00 -3.52E-01 ALDOA -1.24E+00 1.21E+00 1.33E+00 -1.10E+00 1.29E+00 1.31E+00 -2.53E+00 -1.23E+00 -1.09E+00 -1.32E+00 -3.37E+00 -3.37E-01 PRKAR2B 1.17E+00 -1.59E+00 1.79E+00 -1.58E+00 -1.79E+00 -1.36E+00 1.14E+00 1.49E+00 -1.15E+00 -1.44E+00 -3.32E+00 -3.32E-01 C2CD2 -1.23E+00 -1.80E+00 2.13E+00 -1.87E+00 -2.33E+00 1.22E+00 1.51E+00 2.91E+00 -1.35E+00 -2.18E+00 -2.99E+00 -2.99E-01 DDIT4 1.17E+00 1.69E+00 -2.10E+00 2.85E+00 -1.22E+00 1.48E+00 -2.47E+00 -2.88E+00 -2.96E+00 1.85E+00 -2.59E+00 -2.59E-01 SLC6A6 1.94E+00 -2.88E+00 -1.20E+00 2.27E+00 -1.69E+00 1.30E+00 -1.16E+00 2.70E+00 1.31E+00 -4.57E+00 -1.98E+00 -1.98E-01 HSD3B2 -1.29E+00 2.73E+00 1.36E+00 2.23E+00 1.22E+00 -1.47E+00 -1.91E+00 -4.98E+00 -4.23E+00 4.62E+00 -1.72E+00 -1.72E-01 SERPINE1 -2.38E+00 -1.57E+00 1.29E+00 -2.04E+00 -1.45E+00 -2.50E+00 4.28E+00 3.11E+00 1.76E+00 -1.68E+00 -1.18E+00 -1.18E-01 EZR -1.30E+00 -1.33E+00 1.94E+00 -1.88E+00 1.26E+00 -1.15E+00 1.19E+00 1.28E+00 1.14E+00 -1.92E+00 -7.70E-01 -7.70E-02 AHNAK 1.15E+00 -1.54E+00 -1.21E+00 -1.18E+00 -1.65E+00 1.14E+00 1.07E+00 2.04E+00 1.76E+00 -1.75E+00 -1.70E-01 -1.70E-02 SMARCA1 1.27E+00 -1.60E+00 1.12E+00 -1.87E+00 2.07E+00 1.22E+00 1.94E+00 -1.31E+00 -1.40E+00 -1.15E+00 2.90E-01 2.90E-02 MT-ND2 1.10E+00 -1.05E+00 -1.28E+00 -1.68E+00 1.27E+00 1.37E+00 -1.24E+00 1.11E+00 2.16E+00 -1.19E+00 5.70E-01 5.70E-02 ATP1A1 -1.44E+00 -1.28E+00 1.28E+00 -1.47E+00 1.65E+00 -1.38E+00 1.15E+00 1.92E+00 1.31E+00 -1.16E+00 5.80E-01 5.80E-02 INSIG1 1.77E+00 1.32E+00 -1.22E+00 2.09E+00 1.84E+00 2.17E+00 -5.20E+00 -2.37E+00 -1.28E+00 2.12E+00 1.24E+00 1.24E-01 CYB5R3 -1.47E+00 1.21E+00 1.74E+00 -1.25E+00 1.30E+00 1.25E+00 -1.84E+00 1.44E+00 1.26E+00 -2.16E+00 1.48E+00 1.48E-01 TPT1 1.29E+00 1.59E+00 -1.62E+00 -1.20E+00 1.25E+00 1.27E+00 1.14E+00 -1.97E+00 -1.32E+00 1.76E+00 2.19E+00 2.19E-01 TIMP1 -1.19E+00 1.64E+00 -2.03E+00 1.70E+00 3.70E+00 1.28E+00 -1.79E+00 -1.82E+00 -1.46E+00 2.37E+00 2.40E+00 2.40E-01 DHCR24 -1.11E+00 1.15E+00 1.14E+00 1.12E+00 1.48E+00 -1.15E+00 -1.56E+00 1.45E+00 -1.07E+00 1.05E+00 2.50E+00 2.50E-01 IL1R1 -1.26E+00 1.25E+00 -1.94E+00 1.57E+00 1.25E+00 -1.20E+00 1.31E+00 1.24E+00 1.35E+00 1.98E+00 5.55E+00 5.55E-01 S100A10 1.14E+00 1.18E+00 1.61E+00 -1.45E+00 1.69E+00 1.61E+00 -1.35E+00 1.51E+00 1.65E+00 -1.60E+00 5.99E+00 5.99E-01 MT-CYB 1.11E+00 -1.14E+00 1.25E+00 -1.27E+00 2.64E+00 1.33E+00 1.46E+00 -1.07E+00 1.93E+00 2.37E+00 8.61E+00 8.61E-01 OLFML2B 1.88E+00 -3.66E+00 1.51E+00 -4.54E+00 1.77E+00 1.98E+00 2.98E+00 7.83E+00 5.47E+00 -4.89E+00 1.03E+01 1.03E+00 B2M 1.18E+00 -1.30E+00 2.38E+00 1.73E+00 1.82E+00 -1.10E+00 1.36E+00 1.12E+00 1.13E+00 2.22E+00 1.05E+01 1.05E+00 MT-CO3 1.07E+00 1.58E+00 1.49E+00 -1.18E+00 2.13E+00 -1.21E+00 2.24E+00 1.05E+00 1.49E+00 2.15E+00 1.08E+01 1.08E+00 MT-ND4 1.04E+00 1.15E+00 1.60E+00 -1.39E+00 2.04E+00 1.21E+00 1.40E+00 1.16E+00 2.03E+00 1.80E+00 1.20E+01 1.20E+00 MTRNR2L8 -1.40E+00 -1.58E+00 1.39E+00 -1.47E+00 3.28E+00 1.24E+00 5.78E+00 3.55E+00 2.82E+00 -1.18E+00 1.24E+01 1.24E+00 MT-ATP6 1.26E+00 1.17E+00 1.47E+00 -1.46E+00 2.66E+00 1.28E+00 1.51E+00 1.35E+00 2.53E+00 2.23E+00 1.40E+01 1.40E+00 CD24 1.95E+00 1.36E+00 -1.93E+00 1.15E+00 4.10E+00 1.86E+00 2.09E+00 1.58E+00 2.58E+00 1.99E+00 1.67E+01 1.67E+00 DLK1 3.00E+00 -2.67E+00 -2.02E+00 2.44E+00 7.26E+00 1.86E+00 2.31E+00 2.08E+00 3.39E+00 1.84E+00 1.95E+01 1.95E+00 TNC 2.81E+00 2.04E+00 -1.28E+00 2.53E+00 2.23E+01 1.44E+00 -1.11E+00 -2.36E+00 3.28E+00 4.89E+00 3.45E+01 3.45E+00