--------------- TRANSPORTS ----------
Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|VenousBlood_pls_VenousBlood_bc|Surface area (blood cells/plasma)(45398.077535931 [dm²])

Transport: MassTransferBloodPool2OrgPl_lng
	Source: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1
	Formula: (Q*(1-HCT)+Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|Lung|Blood flow rate(6.08968311677683 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Lung|Lymph flow rate(0.000114900141047345 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgRBC_lng
	Source: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|Lung|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Lung|Blood flow rate(6.08968311677683 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_ArterialBlood_bc|Surface area (blood cells/plasma)(19738.1072965671 [dm²])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|Bone|Lymph flow rate(0.000114014111293118 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Bone|Endosome|Volume(0.00229047099250863 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Bone|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|Bone|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_bc|Surface area (blood cells/plasma)(18924.1124423161 [dm²])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Bone|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|Bone|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|Partition coefficient (intracellular/water)(1.96634360525929)

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|Bone|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Bone|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Bone|Endosome|Volume(0.00229047099250863 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Bone|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Bone|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Bone|Endosome|Volume(0.00229047099250863 [l])

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|Bone|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Bone|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Bone|Endosome|Volume(0.00229047099250863 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Bone|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Bone|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Bone|Endosome|Volume(0.00229047099250863 [l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)(3817.45165418105 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|Bone|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Bone|Fluid recirculation flow rate(5.33261345230804E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Bone|Lymph flow rate(0.000114014111293118 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|P (large endothelial pores)(3.10534206964146E-08 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Peclet number (large pores)(0.0769999022300142)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Peclet number (small pores)(269763186557.621)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)(3817.45165418105 [dm²])

Transport: MassTransferOrgPl2BloodPool
	Source: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|Bone|Blood flow rate(0.324956140036248 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Bone|Lymph flow rate(0.000114014111293118 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferOrgRBC2BloodPool
	Source: PBPK_model_human_Ab|Organism|Bone|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Bone|Blood flow rate(0.324956140036248 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|Bone|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferOrgPl2BloodPool
	Source: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|Brain|Blood flow rate(0.779859603835287 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Brain|Lymph flow rate(3.00487703953774E-05 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|Brain|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Brain|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Brain|Endosome|Volume(0.000335486772970652 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Brain|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Brain|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Brain|Endosome|Volume(0.000335486772970652 [l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|Surface area (plasma/interstitial)(559.144621617753 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|Brain|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Brain|Fluid recirculation flow rate(5.58665816421524E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Brain|Lymph flow rate(3.00487703953774E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|P (large endothelial pores)(1.7251900386897E-10 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Peclet number (large pores)(17.6768906004709)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Peclet number (small pores)(500544313172.706)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|Surface area (plasma/interstitial)(559.144621617753 [dm²])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|Brain|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Brain|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Brain|Endosome|Volume(0.000335486772970652 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Brain|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Brain|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Brain|Endosome|Volume(0.000335486772970652 [l])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Brain|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|Brain|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|Partition coefficient (intracellular/water)(1.2177816930632)

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Brain|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|Brain|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_bc|Surface area (blood cells/plasma)(2771.82703268068 [dm²])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|Brain|Lymph flow rate(3.00487703953774E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferOrgRBC2BloodPool
	Source: PBPK_model_human_Ab|Organism|Brain|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Brain|Blood flow rate(0.779859603835287 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|Brain|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Brain|Endosome|Volume(0.000335486772970652 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Fat|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|Fat|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_bc|Surface area (blood cells/plasma)(12425.6689247944 [dm²])

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|Fat|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Fat|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Fat|Endosome|Volume(0.00150393495713527 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Fat|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Fat|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Fat|Endosome|Volume(0.00150393495713527 [l])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Fat|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|Fat|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|Partition coefficient (intracellular/water)(6.3237501733623)

Transport: MassTransferOrgRBC2BloodPool
	Source: PBPK_model_human_Ab|Organism|Fat|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Fat|Blood flow rate(0.320135862220607 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|Fat|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Fat|Endosome|Volume(0.00150393495713527 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: MassTransferOrgPl2BloodPool
	Source: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|Fat|Blood flow rate(0.320135862220607 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Fat|Lymph flow rate(0.00127932693260599 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|Fat|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Fat|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Fat|Endosome|Volume(0.00150393495713527 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Fat|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Fat|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Fat|Endosome|Volume(0.00150393495713527 [l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|Surface area (plasma/interstitial)(2506.55826189211 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|Fat|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Fat|Fluid recirculation flow rate(1.77855852400894E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Fat|Lymph flow rate(0.00127932693260599 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|P (large endothelial pores)(3.10534206964146E-08 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Peclet number (large pores)(0.868915940156526)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Peclet number (small pores)(4777766465446.5)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|Surface area (plasma/interstitial)(2506.55826189211 [dm²])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|Fat|Lymph flow rate(0.00127932693260599 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|Surface area (plasma/interstitial)(21.0405821679742 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|Gonads|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Gonads|Fluid recirculation flow rate(3.20596453218297E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Gonads|Lymph flow rate(1.90943705999462E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|P (large endothelial pores)(3.10534206964146E-08 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Peclet number (large pores)(5.26822635612042)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Peclet number (small pores)(7097563849966.31)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|Surface area (plasma/interstitial)(21.0405821679742 [dm²])

Transport: MassTransferOrgPl2BloodPool
	Source: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|Gonads|Blood flow rate(0.00324568597653343 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Gonads|Lymph flow rate(1.90943705999462E-05 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Gonads|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|Gonads|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_bc|Surface area (blood cells/plasma)(104.303702801955 [dm²])

Transport: MassTransferOrgRBC2BloodPool
	Source: PBPK_model_human_Ab|Organism|Gonads|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Gonads|Blood flow rate(0.00324568597653343 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|Gonads|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Gonads|Endosome|Volume(1.26243493007845E-05 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|Gonads|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Gonads|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Gonads|Endosome|Volume(1.26243493007845E-05 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Gonads|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Gonads|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Gonads|Endosome|Volume(1.26243493007845E-05 [l])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|Gonads|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Gonads|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Gonads|Endosome|Volume(1.26243493007845E-05 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Gonads|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Gonads|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Gonads|Endosome|Volume(1.26243493007845E-05 [l])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|Gonads|Lymph flow rate(1.90943705999462E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Gonads|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|Gonads|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|Partition coefficient (intracellular/water)(1.22025216765946)

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|Heart|Lymph flow rate(0.000202809065392218 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|Surface area (plasma/interstitial)(555.410181164296 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|Heart|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Heart|Fluid recirculation flow rate(1.13227091465884E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Heart|Lymph flow rate(0.000202809065392218 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|P (large endothelial pores)(4.94554477757715E-08 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Peclet number (large pores)(0.646446707650362)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Peclet number (small pores)(3265080639967.15)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|Surface area (plasma/interstitial)(555.410181164296 [dm²])

Transport: MassTransferOrgPl2BloodPool
	Source: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|Heart|Blood flow rate(0.260311982277266 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Heart|Lymph flow rate(0.000202809065392218 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|Heart|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Heart|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Heart|Endosome|Volume(0.000333246108698578 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Heart|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Heart|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Heart|Endosome|Volume(0.000333246108698578 [l])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Heart|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|Heart|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_bc|Surface area (blood cells/plasma)(2753.31442860541 [dm²])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Heart|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|Heart|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|Partition coefficient (intracellular/water)(1.31873161968723)

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Heart|Endosome|Volume(0.000333246108698578 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|Heart|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Heart|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Heart|Endosome|Volume(0.000333246108698578 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Heart|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Heart|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Heart|Endosome|Volume(0.000333246108698578 [l])

Transport: MassTransferOrgRBC2BloodPool
	Source: PBPK_model_human_Ab|Organism|Heart|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Heart|Blood flow rate(0.260311982277266 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|Heart|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferOrgRBC2BloodPool
	Source: PBPK_model_human_Ab|Organism|Kidney|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Kidney|Blood flow rate(1.32718989688807 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|Kidney|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: DrugAbsorption_trans
	Source: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CDA1
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])

Transport: MassTransferMucosaToPvePlasma
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Formula: MassTransferMucosaToPvePlasmaRate
		MassTransferMucosaToPvePlasmaRate: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)(0 [µmol/min])

Transport: MassTransferMucosaToPveBC
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: MassTransferMucosaToPveBCRate
		MassTransferMucosaToPveBCRate: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)(0 [µmol/min])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|Kidney|Lymph flow rate(0.000498718147553631 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Kidney|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|Kidney|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_bc|Surface area (blood cells/plasma)(4749.0515950945 [dm²])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|Kidney|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Kidney|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Kidney|Endosome|Volume(0.000574799212044817 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Kidney|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Kidney|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Kidney|Endosome|Volume(0.000574799212044817 [l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)(957.998686741362 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|Kidney|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Kidney|Fluid recirculation flow rate(3.32038716868045E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Kidney|Lymph flow rate(0.000498718147553631 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|P (large endothelial pores)(4.31297509672425E-07 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Peclet number (large pores)(0.116412201846868)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Peclet number (small pores)(4598945432668.34)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)(957.998686741362 [dm²])

Transport: MassTransferOrgPl2BloodPool
	Source: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|Kidney|Blood flow rate(1.32718989688807 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Kidney|Lymph flow rate(0.000498718147553631 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|Kidney|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Kidney|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Kidney|Endosome|Volume(0.000574799212044817 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Kidney|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Kidney|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Kidney|Endosome|Volume(0.000574799212044817 [l])

Transport: DrugAbsorption_para
	Source: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_pls|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Kidney|Endosome|Volume(0.000574799212044817 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Kidney|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|Kidney|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|Partition coefficient (intracellular/water)(1.24720705329081)

Transport: LumenDrugTransport_uje
	Source: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1
	Target: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1
	Formula: (OralApplicationsEnabled AND IsFloatingInLumen) ? w*Drug*FillLevelFlagNext : 0
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		Drug: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1(0 [µmol])
		IsFloatingInLumen: PBPK_model_human_Ab|CDA1|Is floating in lumen(1)
		w: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Intestinal transit rate (absolute)(1.62619861602195 [1/min])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|FillLevelFlag(1)

Transport: DrugAbsorption_para
	Source: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_pls|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])

Transport: LumenDrugTransport_lil
	Source: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1
	Target: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1
	Formula: (OralApplicationsEnabled AND IsFloatingInLumen) ? w*Drug*FillLevelFlagNext : 0
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		Drug: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1(0 [µmol])
		IsFloatingInLumen: PBPK_model_human_Ab|CDA1|Is floating in lumen(1)
		w: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Intestinal transit rate (absolute)(0.0473069588772936 [1/min])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|FillLevelFlag(1)

Transport: LumenDrugTransport_colasc
	Source: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1
	Target: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1
	Formula: (OralApplicationsEnabled AND IsFloatingInLumen) ? w*Drug*FillLevelFlagNext : 0
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		Drug: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1(0 [µmol])
		IsFloatingInLumen: PBPK_model_human_Ab|CDA1|Is floating in lumen(1)
		w: PBPK_model_human_Ab|Organism|Lumen|Caecum|Intestinal transit rate (absolute)(0.00723156893249226 [1/min])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|FillLevelFlag(1)

Transport: LumenDrugTransport_uil
	Source: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1
	Target: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1
	Formula: (OralApplicationsEnabled AND IsFloatingInLumen) ? w*Drug*FillLevelFlagNext : 0
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		Drug: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1(0 [µmol])
		IsFloatingInLumen: PBPK_model_human_Ab|CDA1|Is floating in lumen(1)
		w: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Intestinal transit rate (absolute)(0.0703218749800801 [1/min])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|FillLevelFlag(1)

Transport: LumenDrugTransport_cae
	Source: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1
	Target: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1
	Formula: (OralApplicationsEnabled AND IsFloatingInLumen) ? w*Drug*FillLevelFlagNext : 0
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		Drug: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1(0 [µmol])
		IsFloatingInLumen: PBPK_model_human_Ab|CDA1|Is floating in lumen(1)
		w: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Intestinal transit rate (absolute)(0.0473069588772936 [1/min])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|Caecum|FillLevelFlag(1)

Transport: LumenDrugTransport_coltrans
	Source: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1
	Target: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1
	Formula: (OralApplicationsEnabled AND IsFloatingInLumen) ? w*Drug*FillLevelFlagNext : 0
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		Drug: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1(0 [µmol])
		IsFloatingInLumen: PBPK_model_human_Ab|CDA1|Is floating in lumen(1)
		w: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Intestinal transit rate (absolute)(0.00394449931681272 [1/min])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|FillLevelFlag(1)

Transport: LumenDrugTransport_coldesc
	Source: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1
	Target: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1
	Formula: (OralApplicationsEnabled AND IsFloatingInLumen) ? w*Drug*FillLevelFlagNext : 0
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		Drug: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1(0 [µmol])
		IsFloatingInLumen: PBPK_model_human_Ab|CDA1|Is floating in lumen(1)
		w: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Intestinal transit rate (absolute)(0.00131481995727318 [1/min])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|FillLevelFlag(1)

Transport: LumenDrugTransport_rect
	Source: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1
	Target: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1
	Formula: (OralApplicationsEnabled AND IsFloatingInLumen) ? w*Drug*FillLevelFlagNext : 0
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		Drug: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1(0 [µmol])
		IsFloatingInLumen: PBPK_model_human_Ab|CDA1|Is floating in lumen(1)
		w: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Intestinal transit rate (absolute)(0.00160702846666267 [1/min])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|Rectum|FillLevelFlag(1)

Transport: LumenDrugTransport_fec
	Source: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1
	Target: PBPK_model_human_Ab|Organism|Lumen|Feces|CDA1
	Formula: OralApplicationsEnabled ? w*Drug : 0
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		Drug: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1(0 [µmol])
		w: PBPK_model_human_Ab|Organism|Lumen|Rectum|Intestinal transit rate (absolute)(0.12449549853738 [1/min])

Transport: LumenDrugTransport_colsigm
	Source: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1
	Target: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1
	Formula: (OralApplicationsEnabled AND IsFloatingInLumen) ? w*Drug*FillLevelFlagNext : 0
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		Drug: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1(0 [µmol])
		IsFloatingInLumen: PBPK_model_human_Ab|CDA1|Is floating in lumen(1)
		w: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Intestinal transit rate (absolute)(0.00197224965840636 [1/min])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|FillLevelFlag(1)

Transport: LumenDrugTransport_lje
	Source: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1
	Target: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1
	Formula: (OralApplicationsEnabled AND IsFloatingInLumen) ? w*Drug*FillLevelFlagNext : 0
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		Drug: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1(0 [µmol])
		IsFloatingInLumen: PBPK_model_human_Ab|CDA1|Is floating in lumen(1)
		w: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Intestinal transit rate (absolute)(0.0703218749800801 [1/min])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|FillLevelFlag(1)

Transport: MassTransferMucosaToPvePlasma
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Formula: MassTransferMucosaToPvePlasmaRate
		MassTransferMucosaToPvePlasmaRate: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)(0 [µmol/min])

Transport: DrugAbsorption_trans
	Source: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CDA1
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])

Transport: LumenDrugTransport_duo
	Source: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1
	Target: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1
	Formula: (OralApplicationsEnabled AND IsFloatingInLumen) ? w*Drug*FillLevelFlagNext : 0
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		Drug: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1(0 [µmol])
		IsFloatingInLumen: PBPK_model_human_Ab|CDA1|Is floating in lumen(1)
		w: PBPK_model_human_Ab|Organism|Lumen|Stomach|Intestinal transit rate (absolute)(0.0666666664926786 [1/min])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|Duodenum|FillLevelFlag(1)

Transport: MassTransferMucosaToPveBC
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: MassTransferMucosaToPveBCRate
		MassTransferMucosaToPveBCRate: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)(0 [µmol/min])

Transport: MassTransferMucosaToPveBC
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: MassTransferMucosaToPveBCRate
		MassTransferMucosaToPveBCRate: PBPK_model_human_Ab|Neighborhoods|UpperIleum_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)(0 [µmol/min])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)(51.2375108392571 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|Stomach|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Stomach|Fluid recirculation flow rate(5.57959880187978E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Stomach|Lymph flow rate(7.03591004386913E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|P (large endothelial pores)(1.37056764184793E-07 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Peclet number (large pores)(1.07177377725536)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Peclet number (small pores)(11956386173221.3)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)(51.2375108392571 [dm²])

Transport: MassTransferOrgPl2BloodPool_pve
	Source: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|Stomach|Blood flow rate(0.0650750096547275 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Stomach|Lymph flow rate(7.03591004386913E-05 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferOrgRBC2BloodPool_Pve
	Source: PBPK_model_human_Ab|Organism|Stomach|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Stomach|Blood flow rate(0.0650750096547275 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|Stomach|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Stomach|Endosome|Volume(3.07425065035542E-05 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|Stomach|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Stomach|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Stomach|Endosome|Volume(3.07425065035542E-05 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Stomach|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Stomach|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Stomach|Endosome|Volume(3.07425065035542E-05 [l])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|Stomach|Lymph flow rate(7.03591004386913E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Stomach|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|Stomach|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_bc|Surface area (blood cells/plasma)(253.997824785681 [dm²])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|Stomach|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Stomach|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Stomach|Endosome|Volume(3.07425065035542E-05 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Stomach|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Stomach|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Stomach|Endosome|Volume(3.07425065035542E-05 [l])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Stomach|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|Stomach|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|Partition coefficient (intracellular/water)(1.22908131578533)

Transport: DrugAbsorption_trans
	Source: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CDA1
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])

Transport: DrugAbsorption_para
	Source: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_pls|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])

Transport: MassTransferMucosaToPvePlasma
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Formula: MassTransferMucosaToPvePlasmaRate
		MassTransferMucosaToPvePlasmaRate: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)(0 [µmol/min])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|Volume(7.95236170849708E-05 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: MassTransferSINToMucosaBC
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|CDA1
	Formula: MassTransferIntestineToMucosaBCRate
		MassTransferIntestineToMucosaBCRate: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_bc_LowerJejunum_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)(0 [µmol/min])

Transport: MassTransferSINToMucosaPlasma
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1
	Formula: MassTransferIntestineToMucosaPlasmaRate
		MassTransferIntestineToMucosaPlasmaRate: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_LowerJejunum_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)(0 [µmol/min])

Transport: DrugAbsorption_para
	Source: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_pls|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])

Transport: MassTransferSinPlasma2BloodPool_Pve
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Formula: ((1-fractQ)*Q*(1-HCT)-Q_lymph)*C
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Blood flow rate(0.650318551621488 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow rate(0.000539296428616088 [l/min])
		fractQ: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa blood flow fraction(0.75)
		C: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: DrugAbsorption_trans
	Source: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CDA1
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_bc|Surface area (blood cells/plasma)(657.03249526309 [dm²])

Transport: MassTransferSINToMucosaBC
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|CDA1
	Formula: MassTransferIntestineToMucosaBCRate
		MassTransferIntestineToMucosaBCRate: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_bc_UpperIleum_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)(0 [µmol/min])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|SmallIntestine|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|Volume(7.95236170849708E-05 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|SmallIntestine|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|Volume(7.95236170849708E-05 [l])

Transport: MassTransferSINToMucosaPlasma
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1
	Formula: MassTransferIntestineToMucosaPlasmaRate
		MassTransferIntestineToMucosaPlasmaRate: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_UpperIleum_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)(0 [µmol/min])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)(132.539361808285 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Fluid recirculation flow rate(9.19788233160212E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow rate(0.000539296428616088 [l/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|P (large endothelial pores)(5.30975156352275E-07 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Peclet number (large pores)(0.425117328598339)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Peclet number (small pores)(37961079485312)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)(132.539361808285 [dm²])

Transport: MassTransferMucosaToPveBC
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: MassTransferMucosaToPveBCRate
		MassTransferMucosaToPveBCRate: PBPK_model_human_Ab|Neighborhoods|LowerIleum_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)(0 [µmol/min])

Transport: MassTransferMucosaToPvePlasma
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Formula: MassTransferMucosaToPvePlasmaRate
		MassTransferMucosaToPvePlasmaRate: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)(0 [µmol/min])

Transport: MassTransferSINToMucosaBC
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|CDA1
	Formula: MassTransferIntestineToMucosaBCRate
		MassTransferIntestineToMucosaBCRate: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_bc_LowerIleum_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)(0 [µmol/min])

Transport: MassTransferSINToMucosaPlasma
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1
	Formula: MassTransferIntestineToMucosaPlasmaRate
		MassTransferIntestineToMucosaPlasmaRate: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_LowerIleum_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)(0 [µmol/min])

Transport: MassTransferSINToMucosaBC
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|CDA1
	Formula: MassTransferIntestineToMucosaBCRate
		MassTransferIntestineToMucosaBCRate: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_bc_Duodenum_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)(0 [µmol/min])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|Partition coefficient (intracellular/water)(1.22908131578533)

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|SmallIntestine|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|Volume(7.95236170849708E-05 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|SmallIntestine|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|Volume(7.95236170849708E-05 [l])

Transport: MassTransferSINToMucosaPlasma
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1
	Formula: MassTransferIntestineToMucosaPlasmaRate
		MassTransferIntestineToMucosaPlasmaRate: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_UpperJejunum_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)(0 [µmol/min])

Transport: MassTransferSINToMucosaPlasma
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1
	Formula: MassTransferIntestineToMucosaPlasmaRate
		MassTransferIntestineToMucosaPlasmaRate: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_Duodenum_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)(0 [µmol/min])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow rate(0.000539296428616088 [l/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferSINToMucosaBC
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|CDA1
	Formula: MassTransferIntestineToMucosaBCRate
		MassTransferIntestineToMucosaBCRate: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_bc_UpperJejunum_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)(0 [µmol/min])

Transport: MassTransferSinRBC2BloodPool_Pve
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: (1-fractQ)*Q*HCT*C
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Blood flow rate(0.650318551621488 [l/min])
		fractQ: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa blood flow fraction(0.75)
		C: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|LargeIntestine|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|Volume(4.49501725481372E-05 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|LargeIntestine|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|Volume(4.49501725481372E-05 [l])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|Volume(4.49501725481372E-05 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|Partition coefficient (intracellular/water)(1.22908131578533)

Transport: MassTransferLinRBC2BloodPool_Pve
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: (1-fractQ)*Q*HCT*C
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Blood flow rate(0.260069878412351 [l/min])
		fractQ: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa blood flow fraction(0.75)
		C: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferLinPlasma2BloodPool_Pve
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Formula: ((1-fractQ)*Q*(1-HCT)-Q_lymph)*C
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Blood flow rate(0.260069878412351 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate(0.0015811341483735 [l/min])
		fractQ: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa blood flow fraction(0.75)
		C: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|LargeIntestine|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|Volume(4.49501725481372E-05 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|LargeIntestine|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|Volume(4.49501725481372E-05 [l])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate(0.0015811341483735 [l/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)(74.9169542468954 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Fluid recirculation flow rate(2.46800420274831E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate(0.0015811341483735 [l/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|P (large endothelial pores)(6.45029386687872E-07 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Peclet number (large pores)(1.77598794053127)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Peclet number (small pores)(197204680005871)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)(74.9169542468954 [dm²])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_bc|Surface area (blood cells/plasma)(371.38305718982 [dm²])

Transport: MassTransferLINToMucosaPlasma
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1
	Formula: MassTransferIntestineToMucosaPlasmaRate
		MassTransferIntestineToMucosaPlasmaRate: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_ColonDescendens_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)(0 [µmol/min])

Transport: MassTransferLINToMucosaPlasma
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1
	Formula: MassTransferIntestineToMucosaPlasmaRate
		MassTransferIntestineToMucosaPlasmaRate: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_ColonTransversum_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)(0 [µmol/min])

Transport: MassTransferLINToMucosaPlasma
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1
	Formula: MassTransferIntestineToMucosaPlasmaRate
		MassTransferIntestineToMucosaPlasmaRate: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_ColonAscendens_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)(0 [µmol/min])

Transport: MassTransferLINToMucosaBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|CDA1
	Formula: MassTransferIntestineToMucosaBCRate
		MassTransferIntestineToMucosaBCRate: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_Caecum_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)(0 [µmol/min])

Transport: MassTransferLINToMucosaBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|CDA1
	Formula: MassTransferIntestineToMucosaBCRate
		MassTransferIntestineToMucosaBCRate: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_ColonDescendens_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)(0 [µmol/min])

Transport: MassTransferLINToMucosaBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|CDA1
	Formula: MassTransferIntestineToMucosaBCRate
		MassTransferIntestineToMucosaBCRate: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_ColonTransversum_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)(0 [µmol/min])

Transport: MassTransferLINToMucosaBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|CDA1
	Formula: MassTransferIntestineToMucosaBCRate
		MassTransferIntestineToMucosaBCRate: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_ColonAscendens_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)(0 [µmol/min])

Transport: MassTransferLINToMucosaPlasma
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1
	Formula: MassTransferIntestineToMucosaPlasmaRate
		MassTransferIntestineToMucosaPlasmaRate: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_ColonSigmoid_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)(0 [µmol/min])

Transport: MassTransferLINToMucosaPlasma
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1
	Formula: MassTransferIntestineToMucosaPlasmaRate
		MassTransferIntestineToMucosaPlasmaRate: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_Caecum_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)(0 [µmol/min])

Transport: MassTransferLINToMucosaBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|CDA1
	Formula: MassTransferIntestineToMucosaBCRate
		MassTransferIntestineToMucosaBCRate: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_Rectum_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)(0 [µmol/min])

Transport: MassTransferLINToMucosaPlasma
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1
	Formula: MassTransferIntestineToMucosaPlasmaRate
		MassTransferIntestineToMucosaPlasmaRate: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_Rectum_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)(0 [µmol/min])

Transport: MassTransferLINToMucosaBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|CDA1
	Formula: MassTransferIntestineToMucosaBCRate
		MassTransferIntestineToMucosaBCRate: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_ColonSigmoid_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)(0 [µmol/min])

Transport: GallbladderEmptying
	Source: PBPK_model_human_Ab|Organism|Gallbladder|CDA1
	Target: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1
	Formula: EHC_Active ? ln(2) / EHC_Halftime * M * EHC_EjectionFraction : 0
		M: PBPK_model_human_Ab|Organism|Gallbladder|CDA1(0 [µmol])
		EHC_EjectionFraction: PBPK_model_human_Ab|Organism|Gallbladder|Gallbladder ejection fraction(0.65)
		EHC_Halftime: PBPK_model_human_Ab|Organism|Gallbladder|Gallbladder ejection half-time(19.7 [min])
		EHC_Active: PBPK_model_human_Ab|Organism|Gallbladder|Gallbladder emptying active(0)

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|Surface area (plasma/interstitial)(3838.19602558808 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|Liver|Periportal|Flow fraction via large pores(0.8)
		J_iso: PBPK_model_human_Ab|Organism|Liver|Periportal|Fluid recirculation flow rate(7.07876482920826E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Liver|Periportal|Lymph flow rate(0.00449682523507667 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|P (large endothelial pores)(1.64194864611518E-06 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|P (small endothelial pores)(1.8023805824505E-07 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Peclet number (large pores)(0.520953407333685)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Peclet number (small pores)(0.28114689432112)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Reflection coefficient (large pores)(0.104991965143301)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Reflection coefficient (small pores)(0.765267156885655)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|Surface area (plasma/interstitial)(3838.19602558808 [dm²])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Liver|Periportal|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume(0.00230291761535285 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Liver|Periportal|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume(0.00230291761535285 [l])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_bc|Surface area (blood cells/plasma)(19026.9477504258 [dm²])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|Partition coefficient (intracellular/water)(1.28715961852841)

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Liver|Periportal|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume(0.00230291761535285 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Liver|Periportal|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume(0.00230291761535285 [l])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_bc|Surface area (blood cells/plasma)(0 [dm²])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Liver|Pericentral|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume(0 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Liver|Pericentral|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume(0 [l])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|Partition coefficient (intracellular/water)(1.28715961852841)

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Liver|Pericentral|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume(0 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Liver|Pericentral|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume(0 [l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|Surface area (plasma/interstitial)(0 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|Liver|Pericentral|Flow fraction via large pores(0.8)
		J_iso: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fluid recirculation flow rate(0 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Liver|Pericentral|Lymph flow rate(0 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|P (large endothelial pores)(1.64194864611518E-06 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|P (small endothelial pores)(1.8023805824505E-07 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Peclet number (large pores)(NaN)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Peclet number (small pores)(NaN)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Reflection coefficient (large pores)(0.104991965143301)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Reflection coefficient (small pores)(0.765267156885655)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|Surface area (plasma/interstitial)(0 [dm²])

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|Lung|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Lung|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Lung|Endosome|Volume(0.00401473234706272 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Lung|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Lung|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Lung|Endosome|Volume(0.00401473234706272 [l])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|Lung|Lymph flow rate(0.000114900141047345 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferOrgPl2BloodPool_Lng
	Source: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1
	Formula: Q*(1-HCT)*C_pls
		Q: PBPK_model_human_Ab|Organism|Lung|Blood flow rate(6.08968311677683 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Lung|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|Lung|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_bc|Surface area (blood cells/plasma)(33170.1412548371 [dm²])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Lung|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|Lung|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|Partition coefficient (intracellular/water)(1.19511249832262)

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)(6691.22057843786 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|Lung|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Lung|Fluid recirculation flow rate(4.76380931227607E-08 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Lung|Lymph flow rate(0.000114900141047345 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|P (large endothelial pores)(1.95521537718166E-08 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Peclet number (large pores)(0.0366305942783084)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Peclet number (small pores)(163060677230.473)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)(6691.22057843786 [dm²])

Transport: MassTransferOrgRBC2BloodPool_Lng
	Source: PBPK_model_human_Ab|Organism|Lung|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Lung|Blood flow rate(6.08968311677683 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|Lung|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Lung|Endosome|Volume(0.00401473234706272 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|Lung|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Lung|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Lung|Endosome|Volume(0.00401473234706272 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Lung|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Lung|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Lung|Endosome|Volume(0.00401473234706272 [l])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Muscle|Endosome|Volume(0.00465123297332342 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|Muscle|Lymph flow rate(0.00118884232037053 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Muscle|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|Muscle|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|Partition coefficient (intracellular/water)(1.19080760296443)

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|Muscle|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Muscle|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Muscle|Endosome|Volume(0.00465123297332342 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Muscle|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Muscle|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Muscle|Endosome|Volume(0.00465123297332342 [l])

Transport: MassTransferOrgRBC2BloodPool
	Source: PBPK_model_human_Ab|Organism|Muscle|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Muscle|Blood flow rate(1.1159695112837 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|Muscle|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferOrgPl2BloodPool
	Source: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|Muscle|Blood flow rate(1.1159695112837 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Muscle|Lymph flow rate(0.00118884232037053 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)(7752.05495553904 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|Muscle|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Muscle|Fluid recirculation flow rate(2.2292095155886E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Muscle|Lymph flow rate(0.00118884232037053 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|P (large endothelial pores)(3.10534206964146E-08 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Peclet number (large pores)(0.280895367290855)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Peclet number (small pores)(1428147911161.36)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)(7752.05495553904 [dm²])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|Muscle|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Muscle|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Muscle|Endosome|Volume(0.00465123297332342 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Muscle|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Muscle|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Muscle|Endosome|Volume(0.00465123297332342 [l])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Muscle|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|Muscle|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_bc|Surface area (blood cells/plasma)(38428.976429069 [dm²])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_bc|Surface area (blood cells/plasma)(1793.69915056893 [dm²])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|Pancreas|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Pancreas|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Pancreas|Endosome|Volume(0.000217099527715695 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Pancreas|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Pancreas|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Pancreas|Endosome|Volume(0.000217099527715695 [l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)(361.832546192824 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|Pancreas|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Pancreas|Fluid recirculation flow rate(8.76759089031544E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Pancreas|Lymph flow rate(0.0010456145699991 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|P (large endothelial pores)(1.11178913604447E-07 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Peclet number (large pores)(1.09320443024707)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Peclet number (small pores)(27428629426862.6)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)(361.832546192824 [dm²])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|Partition coefficient (intracellular/water)(1.36774874200018)

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|Pancreas|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Pancreas|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Pancreas|Endosome|Volume(0.000217099527715695 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Pancreas|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Pancreas|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Pancreas|Endosome|Volume(0.000217099527715695 [l])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Pancreas|Endosome|Volume(0.000217099527715695 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|Pancreas|Lymph flow rate(0.0010456145699991 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferOrgPl2BloodPool_pve
	Source: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|Pancreas|Blood flow rate(0.0651108144964877 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Pancreas|Lymph flow rate(0.0010456145699991 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferOrgRBC2BloodPool_Pve
	Source: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Pancreas|Blood flow rate(0.0651108144964877 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferMucosaToPvePlasma
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Formula: MassTransferMucosaToPvePlasmaRate
		MassTransferMucosaToPvePlasmaRate: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)(0 [µmol/min])

Transport: MassTransferMucosaToPveBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: MassTransferMucosaToPveBCRate
		MassTransferMucosaToPveBCRate: PBPK_model_human_Ab|Neighborhoods|Rectum_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)(0 [µmol/min])

Transport: DrugAbsorption_trans
	Source: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|CDA1
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|PortalVein_pls_PortalVein_bc|Surface area (blood cells/plasma)(48857.0356599865 [dm²])

Transport: MassTransferOrgPl2BloodPool
	Source: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|Skin|Blood flow rate(0.325306825387192 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Skin|Lymph flow rate(0.000606892413442345 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Skin|Endosome|Volume(0.000986644876998516 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|Skin|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Skin|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Skin|Endosome|Volume(0.000986644876998516 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Skin|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Skin|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Skin|Endosome|Volume(0.000986644876998516 [l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)(1644.40812833086 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|Skin|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Skin|Fluid recirculation flow rate(3.26924996641784E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Skin|Lymph flow rate(0.000606892413442345 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|P (large endothelial pores)(6.71864909427472E-08 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Peclet number (large pores)(0.472032370689744)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Peclet number (small pores)(3307301172599.32)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)(1644.40812833086 [dm²])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|Skin|Lymph flow rate(0.000606892413442345 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferOrgRBC2BloodPool
	Source: PBPK_model_human_Ab|Organism|Skin|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Skin|Blood flow rate(0.325306825387192 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|Skin|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|Skin|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Skin|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Skin|Endosome|Volume(0.000986644876998516 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Skin|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Skin|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Skin|Endosome|Volume(0.000986644876998516 [l])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Skin|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|Skin|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|Partition coefficient (intracellular/water)(1.51789558967143)

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Skin|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|Skin|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_bc|Surface area (blood cells/plasma)(8151.76383111721 [dm²])

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|Spleen|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Spleen|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Spleen|Endosome|Volume(0.0003892258435406 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Spleen|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Spleen|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Spleen|Endosome|Volume(0.0003892258435406 [l])

Transport: MassTransferOrgRBC2BloodPool_Pve
	Source: PBPK_model_human_Ab|Organism|Spleen|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Spleen|Blood flow rate(0.165772755931134 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|Spleen|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Spleen|Endosome|Volume(0.0003892258435406 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|Spleen|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|Spleen|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|Partition coefficient (intracellular/water)(1.23528605190271)

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|Spleen|Lymph flow rate(0.00174840525680567 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferOrgPl2BloodPool_pve
	Source: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|Spleen|Blood flow rate(0.165772755931134 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Spleen|Lymph flow rate(0.00174840525680567 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Spleen|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|Spleen|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_bc|Surface area (blood cells/plasma)(3215.82489047386 [dm²])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|Spleen|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|Spleen|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|Spleen|Endosome|Volume(0.0003892258435406 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|Spleen|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|Spleen|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Spleen|Endosome|Volume(0.0003892258435406 [l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)(648.709739234333 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|Spleen|Flow fraction via large pores(0.8)
		J_iso: PBPK_model_human_Ab|Organism|Spleen|Fluid recirculation flow rate(2.75110022586197E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Spleen|Lymph flow rate(0.00174840525680567 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|P (large endothelial pores)(1.64194864611518E-06 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|P (small endothelial pores)(1.8023805824505E-07 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Peclet number (large pores)(1.17553197897659)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Peclet number (small pores)(0.701466970346817)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Reflection coefficient (large pores)(0.104991965143301)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Reflection coefficient (small pores)(0.765267156885655)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)(648.709739234333 [dm²])

Transport: NetMassTransfer_PlasmaToEndosomal_LigandEndo
	Source: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo
	Target: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo
	Formula: f_uptake_vas * K_uptake * V_end * C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|EndogenousIgG|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|EndogenousIgG|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo|Concentration(70 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Transport: NetMassTransfer_PlasmaToEndosomal_FcRn
	Source: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn
	Target: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn
	Formula: f_mem_pls * f_uptake_vas * K_uptake * C_pls * V_end
		f_mem_pls: PBPK_model_human_Ab|Organism|EndogenousIgG|f_membrane_pls(92.9824561403509)
		f_uptake_vas: PBPK_model_human_Ab|Organism|EndogenousIgG|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|EndogenousIgG|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo_Complex
	Target: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|EndogenousIgG|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|EndogenousIgG|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo_Complex|Concentration(227.004075589996 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Transport: NetMassTransfer_InterstitialToEndosomal_LigandEndo
	Source: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo
	Target: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo
	Formula: (1-f_uptake_vas) * K_uptake * V_end * C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|EndogenousIgG|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|EndogenousIgG|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo|Concentration(10.4171706807922 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Transport: NetMassTransfer_InterstitialToEndosomal_FcRn
	Source: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn
	Target: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn
	Formula: f_mem_int * (1-f_uptake_vas) * K_uptake * C_int * V_end
		f_mem_int: PBPK_model_human_Ab|Organism|EndogenousIgG|f_membrane_int(608.420708380725)
		f_uptake_vas: PBPK_model_human_Ab|Organism|EndogenousIgG|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|EndogenousIgG|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo_Complex
	Target: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|EndogenousIgG|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|EndogenousIgG|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo_Complex|Concentration(227.004075589996 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Transport: IgG_SrcToPlasma
	Source: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_Source|LigandEndo
	Target: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo
	Formula: IgG_kin
		IgG_kin: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kin(0.00756579573170419 [µmol/min])

Transport: MassTransferLymphOrgInt2BloodPool_igg
	Source: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo
	Target: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|EndogenousIgG|Lymph flow rate(0.0140728079701645 [l/min])
		C_int: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo|Concentration(10.4171706807922 [µmol/l])

Transport: TwoPoresTransportLink_igg
	Source: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo
	Target: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int)*Pe_s/(exp(Pe_s)-1)
		alpha_l: PBPK_model_human_Ab|Organism|EndogenousIgG|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|EndogenousIgG|Fluid recirculation flow rate(0.000246405447880628 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|EndogenousIgG|Lymph flow rate(0.0140728079701645 [l/min])
		P_endothelial_l: PBPK_model_human_Ab|Organism|EndogenousIgG|P (large endothelial pores)(6.37361108653678E-08 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Organism|EndogenousIgG|P (small endothelial pores)(1E-22 [dm/min])
		Pe_l: PBPK_model_human_Ab|Organism|EndogenousIgG|Peclet number (large pores)(0.416435454772092)
		Pe_s: PBPK_model_human_Ab|Organism|EndogenousIgG|Peclet number (small pores)(4431461283438.54)
		sigma_l: PBPK_model_human_Ab|Organism|EndogenousIgG|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Organism|EndogenousIgG|Reflection coefficient (small pores)(0.999)
		C_int: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo|Concentration(10.4171706807922 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo|Concentration(70 [µmol/l])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_int_EndogenousIgG_pls|Surface area (plasma/interstitial)(29612.719787982 [dm²])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo
	Target: PBPK_model_human_Ab|Organism|EndogenousIgG|EndosomalClearance|LigandEndo
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo|Concentration(2.05671582655156 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: PassiveDiffusionPlsToSaliva
	Source: PBPK_model_human_Ab|Organism|Saliva|SalivaGland|CDA1
	Target: PBPK_model_human_Ab|Organism|Saliva|Saliva|CDA1
	Formula: fu * (C_pls_art - C_slv / K_slv_pls) * Q_slv
		Q_slv: PBPK_model_human_Ab|Organism|Saliva|Saliva flow rate(0.001 [l/min])
		C_pls_art: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		C_slv: PBPK_model_human_Ab|Organism|Saliva|Saliva|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_slv_pls: PBPK_model_human_Ab|Neighborhoods|Saliva_slv_Saliva_slv|CDA1|Partition coefficient (intracellular/plasma)(1)

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume(1.21431096502194E-05 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume(1.21431096502194E-05 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume(1.21431096502194E-05 [l])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_bc|Surface area (blood cells/plasma)(100.327650152181 [dm²])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume(1.21431096502194E-05 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume(1.21431096502194E-05 [l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)(20.238516083699 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fluid recirculation flow rate(2.59292246187488E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Lymph flow rate(1.52029975265403E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|P (large endothelial pores)(5.30975156352275E-07 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Peclet number (large pores)(0.0784831991258472)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Peclet number (small pores)(7008199289596.06)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)(20.238516083699 [dm²])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume(3.47544172747659E-05 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)(57.9240287912764 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fluid recirculation flow rate(7.42112290812464E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Lymph flow rate(4.35120274035463E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|P (large endothelial pores)(5.30975156352275E-07 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Peclet number (large pores)(0.0784831991258473)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Peclet number (small pores)(7008199289596.06)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)(57.9240287912764 [dm²])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume(3.47544172747659E-05 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume(3.47544172747659E-05 [l])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_bc|Surface area (blood cells/plasma)(287.144653883829 [dm²])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume(3.47544172747659E-05 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume(3.47544172747659E-05 [l])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume(2.56819790303491E-05 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume(2.56819790303491E-05 [l])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_bc|Surface area (blood cells/plasma)(212.187214114958 [dm²])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume(2.56819790303491E-05 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume(2.56819790303491E-05 [l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)(42.8032983839151 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fluid recirculation flow rate(5.48388198833307E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Lymph flow rate(3.21534660331426E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|P (large endothelial pores)(5.30975156352275E-07 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Peclet number (large pores)(0.0784831991258473)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Peclet number (small pores)(7008199289596.07)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)(42.8032983839151 [dm²])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume(2.56819790303491E-05 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume(2.26113076245465E-05 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume(2.26113076245465E-05 [l])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_bc|Surface area (blood cells/plasma)(186.817003731648 [dm²])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume(2.26113076245465E-05 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume(2.26113076245465E-05 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume(2.26113076245465E-05 [l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)(37.6855127075774 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fluid recirculation flow rate(4.82820044624977E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Lymph flow rate(2.8309029877006E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|P (large endothelial pores)(5.30975156352275E-07 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Peclet number (large pores)(0.0784831991258473)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Peclet number (small pores)(7008199289596.07)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)(37.6855127075774 [dm²])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume(1.08869258933002E-05 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume(1.08869258933002E-05 [l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)(18.1448764888336 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fluid recirculation flow rate(2.32468910374989E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Lymph flow rate(1.36302736444844E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|P (large endothelial pores)(5.30975156352275E-07 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Peclet number (large pores)(0.0784831991258473)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Peclet number (small pores)(7008199289596.07)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)(18.1448764888336 [dm²])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume(1.08869258933002E-05 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume(1.08869258933002E-05 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume(1.08869258933002E-05 [l])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_bc|Surface area (blood cells/plasma)(89.9489277226451 [dm²])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume(4.91915300807037E-06 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)(8.19858834678396 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fluid recirculation flow rate(4.98623511035952E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Lymph flow rate(3.19444618288292E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|P (large endothelial pores)(6.45029386687872E-07 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Peclet number (large pores)(0.327874696713464)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Peclet number (small pores)(36407017847237.7)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)(8.19858834678396 [dm²])

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume(4.91915300807037E-06 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume(4.91915300807037E-06 [l])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_bc|Surface area (blood cells/plasma)(40.6425599582572 [dm²])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume(4.91915300807037E-06 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume(4.91915300807037E-06 [l])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume(9.01844756861792E-06 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume(9.01844756861792E-06 [l])

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume(9.01844756861792E-06 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume(9.01844756861792E-06 [l])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_bc|Surface area (blood cells/plasma)(74.5113631221917 [dm²])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume(9.01844756861792E-06 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)(15.0307459476965 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fluid recirculation flow rate(9.14143142809429E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Lymph flow rate(5.85648492003344E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|P (large endothelial pores)(6.45029386687872E-07 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Peclet number (large pores)(0.327874696713464)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Peclet number (small pores)(36407017847237.7)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)(15.0307459476965 [dm²])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume(1.8959650986912E-05 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume(1.8959650986912E-05 [l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)(31.59941831152 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fluid recirculation flow rate(2.08197191093004E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Lymph flow rate(0.000133382142569294 [l/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|P (large endothelial pores)(6.45029386687872E-07 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Peclet number (large pores)(0.355197588106253)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Peclet number (small pores)(39440936001174.1)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)(31.59941831152 [dm²])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_bc|Surface area (blood cells/plasma)(156.646632206603 [dm²])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume(1.8959650986912E-05 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume(1.8959650986912E-05 [l])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume(1.8959650986912E-05 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_bc|Surface area (blood cells/plasma)(78.3233161033013 [dm²])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume(9.47982549345601E-06 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume(9.47982549345601E-06 [l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)(15.79970915576 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fluid recirculation flow rate(1.04098595546502E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Lymph flow rate(6.66910712846469E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|P (large endothelial pores)(6.45029386687872E-07 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Peclet number (large pores)(0.355197588106253)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Peclet number (small pores)(39440936001174.1)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)(15.79970915576 [dm²])

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume(9.47982549345601E-06 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume(9.47982549345601E-06 [l])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume(9.47982549345601E-06 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume(7.61771691438429E-06 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume(7.61771691438429E-06 [l])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume(7.61771691438429E-06 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_bc|Surface area (blood cells/plasma)(62.9383790115814 [dm²])

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume(7.61771691438429E-06 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume(7.61771691438429E-06 [l])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)(12.6961948573072 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fluid recirculation flow rate(1.25475985703373E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Lymph flow rate(8.0386559137744E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|P (large endothelial pores)(6.45029386687872E-07 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Peclet number (large pores)(0.53279638215938)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Peclet number (small pores)(59161404001761.2)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)(12.6961948573072 [dm²])

Transport: PassiveDiffusionInt2Cell
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|CDA1
	Formula: K_water_int * PA_int_cell * C_int - K_water_cell * PA_cell_int * C_cell
		C_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1|Concentration(0 [µmol/l])
		PA_int_cell: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|P*SA interstitial -> intracellular(0 [l/min])
		PA_cell_int: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|P*SA intracellular -> interstitial(0 [l/min])
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Transport: PassiveDiffusionPl2RBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|CDA1
	Formula: SA_bc * fu * (P_pls_rbc * C_pls - P_rbc_pls * C_bc  /K_rbc)
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_rbc_pls: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)(0 [dm/min])
		P_pls_rbc: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)(0 [dm/min])
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)
		SA_bc: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_bc|Surface area (blood cells/plasma)(25.6415618195332 [dm²])

Transport: PassiveDiffusionPl2Int
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1
	Formula: fu * P_endothelial * SA * (C_pls - C_int / K_int_pls)
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|P (plasma<->interstitial)(0 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		SA: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)(5.17252383075477 [dm²])

Transport: TwoPoresTransportLink
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1
	Formula: fu * ((J_iso+alpha_l*Q_lymph)*(1-sigma_l)*C_pl+(P_endothelial_l*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_l/(exp(Pe_l)-1) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)*C_pl+(P_endothelial_s*SA_pls_int)*(C_pl-C_int/K_int_pls)*Pe_s/(exp(Pe_s)-1))
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fluid recirculation flow rate(5.11198460273E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Lymph flow rate(3.27500796487105E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pl: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|P (large endothelial pores)(6.45029386687872E-07 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)
		Pe_l: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Peclet number (large pores)(0.53279638215938)
		Pe_s: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Peclet number (small pores)(59161404001761.2)
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)(5.17252383075477 [dm²])

Transport: NetMassTransfer_PlasmaToEndosomal
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1
	Formula: f_uptake_vas*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_pls
		f_uptake_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Rate constant for endosomal uptake(0.294 [1/min])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume(3.10351429845286E-06 [l])

Transport: NetMassTransfer_EndosomalToPlasma_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1-FcRn_Complex
	Formula: f_rec_vas * K_rec * C_IgG_FcRn * V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume(3.10351429845286E-06 [l])

Transport: NetMassTransfer_InterstitialToEndosomal
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1
	Formula: (1-f_uptake_vas)*(IsSmallMolecule ? 0 : K_uptake)*V_end*C_int
		f_uptake_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Rate constant for endosomal uptake(0.294 [1/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1|Concentration(0 [µmol/l])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume(3.10351429845286E-06 [l])

Transport: NetMassTransfer_EndosomalToInterstitial_FcRn_Complex
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1-FcRn_Complex
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1-FcRn_Complex
	Formula: (1-f_rec_vas)*K_rec*C_IgG_FcRn*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Rate constant for recycling from endosomal space(0.0888 [1/min])
		C_IgG_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume(3.10351429845286E-06 [l])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume(3.10351429845286E-06 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: MassTransferMucosaToPvePlasma
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Formula: MassTransferMucosaToPvePlasmaRate
		MassTransferMucosaToPvePlasmaRate: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)(0 [µmol/min])

Transport: MassTransferMucosaToPveBC
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: MassTransferMucosaToPveBCRate
		MassTransferMucosaToPveBCRate: PBPK_model_human_Ab|Neighborhoods|Duodenum_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)(0 [µmol/min])

Transport: DrugAbsorption_trans
	Source: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CDA1
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])

Transport: DrugAbsorption_para
	Source: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_pls|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])

Transport: MassTransferBloodPool2OrgRBC
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|Bone|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Bone|Blood flow rate(0.324956140036248 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgPl
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1
	Formula: Q*(1-HCT)*C_pls
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Blood flow rate(0.260069878412351 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgRBC
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Blood flow rate(0.650318551621488 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgRBC
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|Spleen|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Spleen|Blood flow rate(0.165772755931134 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgRBC
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|Stomach|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Stomach|Blood flow rate(0.0650750096547275 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgPl
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1
	Formula: Q*(1-HCT)*C_pls
		Q: PBPK_model_human_Ab|Organism|Bone|Blood flow rate(0.324956140036248 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgPl
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1
	Formula: Q*(1-HCT)*C_pls
		Q: PBPK_model_human_Ab|Organism|Brain|Blood flow rate(0.779859603835287 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgPl
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1
	Formula: Q*(1-HCT)*C_pls
		Q: PBPK_model_human_Ab|Organism|Fat|Blood flow rate(0.320135862220607 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgPl
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1
	Formula: Q*(1-HCT)*C_pls
		Q: PBPK_model_human_Ab|Organism|Gonads|Blood flow rate(0.00324568597653343 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgPl
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1
	Formula: Q*(1-HCT)*C_pls
		Q: PBPK_model_human_Ab|Organism|Kidney|Blood flow rate(1.32718989688807 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgPl
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1
	Formula: Q*(1-HCT)*C_pls
		Q: PBPK_model_human_Ab|Organism|Muscle|Blood flow rate(1.1159695112837 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgPl
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1
	Formula: Q*(1-HCT)*C_pls
		Q: PBPK_model_human_Ab|Organism|Pancreas|Blood flow rate(0.0651108144964877 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgPl
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1
	Formula: Q*(1-HCT)*C_pls
		Q: PBPK_model_human_Ab|Organism|Skin|Blood flow rate(0.325306825387192 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgPl
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1
	Formula: Q*(1-HCT)*C_pls
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Blood flow rate(0.650318551621488 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgPl
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1
	Formula: Q*(1-HCT)*C_pls
		Q: PBPK_model_human_Ab|Organism|Spleen|Blood flow rate(0.165772755931134 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgPl
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1
	Formula: Q*(1-HCT)*C_pls
		Q: PBPK_model_human_Ab|Organism|Stomach|Blood flow rate(0.0650750096547275 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgPl
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1
	Formula: Q*(1-HCT)*C_pls
		Q: PBPK_model_human_Ab|Organism|Heart|Blood flow rate(0.260311982277266 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgRBC
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|Skin|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Skin|Blood flow rate(0.325306825387192 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgRBC
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|Brain|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Brain|Blood flow rate(0.779859603835287 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgRBC
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|Fat|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Fat|Blood flow rate(0.320135862220607 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgRBC
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|Gonads|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Gonads|Blood flow rate(0.00324568597653343 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgRBC
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|Heart|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Heart|Blood flow rate(0.260311982277266 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgRBC
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|Kidney|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Kidney|Blood flow rate(1.32718989688807 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgRBC
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Blood flow rate(0.260069878412351 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgRBC
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Pancreas|Blood flow rate(0.0651108144964877 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgRBC
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|Muscle|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Muscle|Blood flow rate(1.1159695112837 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferMucosaToPveBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: MassTransferMucosaToPveBCRate
		MassTransferMucosaToPveBCRate: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)(0 [µmol/min])

Transport: MassTransferMucosaToPvePlasma
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Formula: MassTransferMucosaToPvePlasmaRate
		MassTransferMucosaToPvePlasmaRate: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)(0 [µmol/min])

Transport: DrugAbsorption_trans
	Source: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|CDA1
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])

Transport: MassTransferMucosaToPveBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: MassTransferMucosaToPveBCRate
		MassTransferMucosaToPveBCRate: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)(0 [µmol/min])

Transport: MassTransferMucosaToPvePlasma
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Formula: MassTransferMucosaToPvePlasmaRate
		MassTransferMucosaToPvePlasmaRate: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)(0 [µmol/min])

Transport: DrugAbsorption_trans
	Source: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|CDA1
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])

Transport: MassTransferMucosaToPveBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: MassTransferMucosaToPveBCRate
		MassTransferMucosaToPveBCRate: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)(0 [µmol/min])

Transport: MassTransferMucosaToPveBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: MassTransferMucosaToPveBCRate
		MassTransferMucosaToPveBCRate: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)(0 [µmol/min])

Transport: MassTransferMucosaToPvePlasma
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Formula: MassTransferMucosaToPvePlasmaRate
		MassTransferMucosaToPvePlasmaRate: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)(0 [µmol/min])

Transport: DrugAbsorption_trans
	Source: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|CDA1
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])

Transport: MassTransferMucosaToPveBC
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Formula: MassTransferMucosaToPveBCRate
		MassTransferMucosaToPveBCRate: PBPK_model_human_Ab|Neighborhoods|Caecum_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)(0 [µmol/min])

Transport: MassTransferMucosaToPvePlasma
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Formula: MassTransferMucosaToPvePlasmaRate
		MassTransferMucosaToPvePlasmaRate: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)(0 [µmol/min])

Transport: DrugAbsorption_trans
	Source: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|CDA1
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])

Transport: MassTransferMucosaToPvePlasma
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Formula: MassTransferMucosaToPvePlasmaRate
		MassTransferMucosaToPvePlasmaRate: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)(0 [µmol/min])

Transport: DrugAbsorption_trans
	Source: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1
	Target: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|CDA1
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Lymph flow rate(6.66910712846469E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Lymph flow rate(0.000133382142569294 [l/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Lymph flow rate(5.85648492003344E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Lymph flow rate(3.19444618288292E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Lymph flow rate(1.36302736444844E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Lymph flow rate(2.8309029877006E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Lymph flow rate(4.35120274035463E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Lymph flow rate(3.21534660331426E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Lymph flow rate(8.0386559137744E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Lymph flow rate(3.27500796487105E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Lymph flow rate(1.52029975265403E-05 [l/min])
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|Liver|Periportal|Lymph flow rate(0.00449682523507667 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransferOrgPl2BloodPool_Liv_Pericentral
	Source: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: IsLiverZonated ? ((Q_liv+Q_pve)*(1-HCT)-Q_lymph_periportal-Q_lymph_pericentral-Q_lymph_pve)*C_pls : 0
		Q_liv: PBPK_model_human_Ab|Organism|Liver|Pericentral|Blood flow rate(0.426360598755729 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)
		Q_pve: PBPK_model_human_Ab|Organism|PortalVein|Blood flow rate(1.20634701011619 [l/min])
		Q_lymph_pve: PBPK_model_human_Ab|Organism|PortalVein|Lymph flow rate(0.00552133646238733 [l/min])
		Q_lymph_periportal: PBPK_model_human_Ab|Organism|Liver|Periportal|Lymph flow rate(0.00449682523507667 [l/min])
		Q_lymph_pericentral: PBPK_model_human_Ab|Organism|Liver|Pericentral|Lymph flow rate(0 [l/min])

Transport: MassTransferOrgPl2BloodPool_Liv
	Source: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: IsLiverZonated ? 0 : ((Q_liv+Q_pve)*(1-HCT)-Q_lymph_periportal-Q_lymph_pve)*C_pls
		Q_liv: PBPK_model_human_Ab|Organism|Liver|Periportal|Blood flow rate(0.426360598755729 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)
		Q_pve: PBPK_model_human_Ab|Organism|PortalVein|Blood flow rate(1.20634701011619 [l/min])
		Q_lymph_pve: PBPK_model_human_Ab|Organism|PortalVein|Lymph flow rate(0.00552133646238733 [l/min])
		Q_lymph_periportal: PBPK_model_human_Ab|Organism|Liver|Periportal|Lymph flow rate(0.00449682523507667 [l/min])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume(0.00230291761535285 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: EndosomalSpecificClearance_FirstOrder
	Source: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1
	Target: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1
	Formula: CLspec*C_end*V_end
		C_end: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1|Concentration(0 [µmol/l])
		V_end: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume(0 [l])
		CLspec: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Transport: MassTransfer_PeriportalToPericentral_BC
	Source: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|CDA1
	Formula: IsLiverZonated ? (Q_liv +Q_pve)*HCT*C_bc : 0
		Q_liv: PBPK_model_human_Ab|Organism|Liver|Periportal|Blood flow rate(0.426360598755729 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1|Concentration(0 [µmol/l])
		Q_pve: PBPK_model_human_Ab|Organism|PortalVein|Blood flow rate(1.20634701011619 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)

Transport: MassTransferLymphOrgInt2BloodPool
	Source: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: Q_lymph*C_int
		Q_lymph: PBPK_model_human_Ab|Organism|Liver|Pericentral|Lymph flow rate(0 [l/min])
		C_int: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Concentration(0 [µmol/l])

Transport: MassTransfer_PeriportalToPericentral_Plasma
	Source: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1
	Formula: IsLiverZonated ? ((Q_liv +Q_pve)*(1-HCT)-Q_lymph_periportal-Q_lymph_pve)*C_pls : 0
		Q_liv: PBPK_model_human_Ab|Organism|Liver|Periportal|Blood flow rate(0.426360598755729 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1|Concentration(0 [µmol/l])
		Q_pve: PBPK_model_human_Ab|Organism|PortalVein|Blood flow rate(1.20634701011619 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)
		Q_lymph_pve: PBPK_model_human_Ab|Organism|PortalVein|Lymph flow rate(0.00552133646238733 [l/min])
		Q_lymph_periportal: PBPK_model_human_Ab|Organism|Liver|Periportal|Lymph flow rate(0.00449682523507667 [l/min])

Transport: MassTransferBloodPool2OrgRBC
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|Liver|Periportal|Blood flow rate(0.426360598755729 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgPl
	Source: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1
	Formula: Q*(1-HCT)*C_pls
		Q: PBPK_model_human_Ab|Organism|Liver|Periportal|Blood flow rate(0.426360598755729 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgRBC_liv
	Source: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|PortalVein|Blood flow rate(1.20634701011619 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferBloodPool2OrgPl_liv
	Source: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1
	Target: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|PortalVein|Blood flow rate(1.20634701011619 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|PortalVein|Lymph flow rate(0.00552133646238733 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Transport: MassTransferOrgRBC2BloodPool_Liv_Pericentral
	Source: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1
	Formula: IsLiverZonated ? (Q_liv +Q_pve)*HCT*C_bc : 0
		Q_liv: PBPK_model_human_Ab|Organism|Liver|Pericentral|Blood flow rate(0.426360598755729 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)
		Q_pve: PBPK_model_human_Ab|Organism|PortalVein|Blood flow rate(1.20634701011619 [l/min])

Transport: MassTransferOrgRBC2BloodPool_Liv
	Source: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1
	Formula: IsLiverZonated ? 0 : (Q_liv +Q_pve)*HCT*C_bc
		Q_liv: PBPK_model_human_Ab|Organism|Liver|Periportal|Blood flow rate(0.426360598755729 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)
		Q_pve: PBPK_model_human_Ab|Organism|PortalVein|Blood flow rate(1.20634701011619 [l/min])

Transport: Intravenous_Transport
	Source: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: ApplicationRate
		ApplicationRate: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|Application rate(0 [µmol/min])

Transport: Intravenous_Transport
	Source: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|CDA1
	Target: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1
	Formula: ApplicationRate
		ApplicationRate: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|Application rate(0 [µmol/min])

--------------- REACTIONS ----------
Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Bone|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Bone|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Bone|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Brain|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Brain|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Brain|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Fat|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Fat|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Fat|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Gonads|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Gonads|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Gonads|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Heart|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Heart|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Heart|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Kidney|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Kidney|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Kidney|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Stomach|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Stomach|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Stomach|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Lung|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Lung|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Lung|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Muscle|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Muscle|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Muscle|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Pancreas|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Pancreas|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Skin|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Skin|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Skin|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Spleen|Plasma|FcRn concentration in container(0.737391752667387 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Spleen|Interstitial|FcRn concentration in container(0 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1|Kd (FcRn) in endosomal space of container(999999 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding tissue CDA1
	Educts:
		1 * PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1
	Products:
		1 * PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1-FcRn_Complex
	Formula: kass_FcRn * drug * FcRn - Kd_FcRn_drug * kass_FcRn * drug_FcRn
		FcRn: PBPK_model_human_Ab|Organism|Spleen|Endosome|FcRn concentration in container(80.8 [µmol/l])
		drug: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1|Kd (FcRn) in endosomal space of container(0.63 [µmol/l])
		drug_FcRn: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1-FcRn_Complex(0 [µmol])

Reaction: FcRn binding CDA1 in plasma
	Educts:
		1 * PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn
	Products:
	Formula: kass_FcRn*FcRn*(M_bon+M_brn+M_fat+M_tes+M_hrt+M_kid+M_lin+M_liv_periportal + (IsLiverZonated ? M_liv_pericentral : 0)+M_lng+M_mus+M_pan+M_skn+M_sin+M_spl+M_sto+M_duo+M_uje+M_lje+M_uil+M_lil+M_cae+M_colasc+M_coltrans+M_coldesc+M_colsigm+M_rect) - Kd_FcRn_drug*kass_FcRn*(MC_bon+MC_brn+MC_fat+MC_tes+MC_hrt+MC_kid+MC_lin+MC_liv_periportal + (IsLiverZonated ? MC_liv_pericentral : 0)+MC_lng+MC_mus+MC_pan+MC_skn+MC_sin+MC_spl+MC_sto+MC_duo+MC_uje+MC_lje+MC_uil+MC_lil+MC_cae+MC_colasc+MC_coltrans+MC_coldesc+MC_colsigm+MC_rect)
		M_bon: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1(0 [µmol])
		M_brn: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1(0 [µmol])
		M_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1(0 [µmol])
		M_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1(0 [µmol])
		M_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1(0 [µmol])
		M_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1(0 [µmol])
		M_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1(0 [µmol])
		M_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1(0 [µmol])
		M_fat: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1(0 [µmol])
		M_hrt: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1(0 [µmol])
		M_kid: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1(0 [µmol])
		M_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1(0 [µmol])
		M_lin: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1(0 [µmol])
		M_liv_pericentral: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1(0 [µmol])
		M_liv_periportal: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1(0 [µmol])
		M_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1(0 [µmol])
		M_lng: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1(0 [µmol])
		M_mus: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1(0 [µmol])
		M_pan: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1(0 [µmol])
		M_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1(0 [µmol])
		M_sin: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1(0 [µmol])
		M_skn: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1(0 [µmol])
		M_spl: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1(0 [µmol])
		M_sto: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1(0 [µmol])
		M_tes: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1(0 [µmol])
		M_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1(0 [µmol])
		M_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])
		MC_bon: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_brn: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_fat: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_hrt: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_kid: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_lin: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_liv_pericentral: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_liv_periportal: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_lng: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_mus: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_pan: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_sin: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_skn: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_spl: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_sto: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_tes: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		MC_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)

Reaction: FcRn binding endogenous Igg
	Educts:
		1 * PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn
		1 * PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo
	Products:
		1 * PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo_Complex
	Formula: kass_FcRn*FcRn*LigandEndo - Kd_FcRn_IgGendo*kass_FcRn*IgG_endo_FcRn
		Kd_FcRn_IgGendo: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Kd (FcRn, endogenous IgG) in endosomal space of container(10000 [µmol/l])
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn(1.22914255534983 [µmol])
		LigandEndo: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo|Concentration(70 [µmol/l])
		IgG_endo_FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo_Complex(0.00864553442897442 [µmol])
		kass_FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|kass (FcRn, endogenous IgG)(0.87 [l/µmol/min])

Reaction: FcRn binding CDA1 in interstitial
	Educts:
		1 * PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn
	Products:
	Formula: kass_FcRn*FcRn*(M_bon+M_brn+M_fat+M_tes+M_hrt+M_kid+M_lin+M_liv_periportal + (IsLiverZonated ? M_liv_pericentral : 0)+M_lng+M_mus+M_pan+M_skn+M_sin+M_spl+M_sto+M_duo+M_uje+M_lje+M_uil+M_lil+M_cae+M_colasc+M_coltrans+M_coldesc+M_colsigm+M_rect) - Kd_FcRn_drug*kass_FcRn*(MC_bon+MC_brn+MC_fat+MC_tes+MC_hrt+MC_kid+MC_lin+MC_liv_periportal + (IsLiverZonated ? MC_liv_pericentral : 0)+MC_lng+MC_mus+MC_pan+MC_skn+MC_sin+MC_spl+MC_sto+MC_duo+MC_uje+MC_lje+MC_uil+MC_lil+MC_cae+MC_colasc+MC_coltrans+MC_coldesc+MC_colsigm+MC_rect)
		M_bon: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1(0 [µmol])
		M_brn: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1(0 [µmol])
		M_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1(0 [µmol])
		M_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1(0 [µmol])
		M_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1(0 [µmol])
		M_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1(0 [µmol])
		M_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1(0 [µmol])
		M_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1(0 [µmol])
		M_fat: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1(0 [µmol])
		M_hrt: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1(0 [µmol])
		M_kid: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1(0 [µmol])
		M_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1(0 [µmol])
		M_lin: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1(0 [µmol])
		M_liv_pericentral: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1(0 [µmol])
		M_liv_periportal: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1(0 [µmol])
		M_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1(0 [µmol])
		M_lng: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1(0 [µmol])
		M_mus: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1(0 [µmol])
		M_pan: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1(0 [µmol])
		M_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1(0 [µmol])
		M_sin: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1(0 [µmol])
		M_skn: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1(0 [µmol])
		M_spl: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1(0 [µmol])
		M_sto: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1(0 [µmol])
		M_tes: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1(0 [µmol])
		M_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1(0 [µmol])
		M_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])
		MC_bon: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_brn: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_fat: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_hrt: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_kid: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_lin: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_liv_pericentral: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_liv_periportal: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_lng: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_mus: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_pan: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_sin: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_skn: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_spl: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_sto: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_tes: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		MC_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)

Reaction: FcRn binding endogenous Igg
	Educts:
		1 * PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn
		1 * PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo
	Products:
		1 * PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo_Complex
	Formula: kass_FcRn*FcRn*LigandEndo - Kd_FcRn_IgGendo*kass_FcRn*IgG_endo_FcRn
		Kd_FcRn_IgGendo: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|Kd (FcRn, endogenous IgG) in endosomal space of container(10000 [µmol/l])
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn(0 [µmol])
		LigandEndo: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo|Concentration(10.4171706807922 [µmol/l])
		IgG_endo_FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo_Complex(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|kass (FcRn, endogenous IgG)(0.87 [l/µmol/min])

Reaction: FcRn binding CDA1 in endosomal space
	Educts:
		1 * PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn
	Products:
	Formula: kass_FcRn*FcRn*(M_bon+M_brn+M_fat+M_tes+M_hrt+M_kid+M_lin+M_liv_periportal + (IsLiverZonated ? M_liv_pericentral : 0)+M_lng+M_mus+M_pan+M_skn+M_sin+M_spl+M_sto+M_duo+M_uje+M_lje+M_uil+M_lil+M_cae+M_colasc+M_coltrans+M_coldesc+M_colsigm+M_rect) - Kd_FcRn_drug*kass_FcRn*(MC_bon+MC_brn+MC_fat+MC_tes+MC_hrt+MC_kid+MC_lin+MC_liv_periportal + (IsLiverZonated ? MC_liv_pericentral : 0)+MC_lng+MC_mus+MC_pan+MC_skn+MC_sin+MC_spl+MC_sto+MC_duo+MC_uje+MC_lje+MC_uil+MC_lil+MC_cae+MC_colasc+MC_coltrans+MC_coldesc+MC_colsigm+MC_rect)
		M_bon: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1(0 [µmol])
		M_brn: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1(0 [µmol])
		M_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1(0 [µmol])
		M_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1(0 [µmol])
		M_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1(0 [µmol])
		M_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1(0 [µmol])
		M_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1(0 [µmol])
		M_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1(0 [µmol])
		M_fat: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1(0 [µmol])
		M_hrt: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1(0 [µmol])
		M_kid: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1(0 [µmol])
		M_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1(0 [µmol])
		M_lin: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1(0 [µmol])
		M_liv_pericentral: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1(0 [µmol])
		M_liv_periportal: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1(0 [µmol])
		M_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1(0 [µmol])
		M_lng: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1(0 [µmol])
		M_mus: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1(0 [µmol])
		M_pan: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1(0 [µmol])
		M_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1(0 [µmol])
		M_sin: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1(0 [µmol])
		M_skn: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1(0 [µmol])
		M_spl: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1(0 [µmol])
		M_sto: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1(0 [µmol])
		M_tes: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1(0 [µmol])
		M_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1(0 [µmol])
		M_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1(0 [µmol])
		kass_FcRn: PBPK_model_human_Ab|CDA1|kass (FcRn)(0.87 [l/µmol/min])
		Kd_FcRn_drug: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])
		MC_bon: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_brn: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_fat: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_hrt: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_kid: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_lin: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_liv_pericentral: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_liv_periportal: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_lng: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_mus: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_pan: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_sin: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_skn: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_spl: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_sto: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_tes: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		MC_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)

Reaction: FcRn binding endogenous Igg
	Educts:
		1 * PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn
		1 * PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo
	Products:
		1 * PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo_Complex
	Formula: kass_FcRn*FcRn*LigandEndo - Kd_FcRn_IgGendo*kass_FcRn*IgG_endo_FcRn
		Kd_FcRn_IgGendo: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Kd (FcRn, endogenous IgG) in endosomal space of container(0.63 [µmol/l])
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn(1.44848607997901 [µmol])
		LigandEndo: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo|Concentration(2.05671582655156 [µmol/l])
		IgG_endo_FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo_Complex(4.06945846027984 [µmol])
		kass_FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|kass (FcRn, endogenous IgG)(0.87 [l/µmol/min])

--------------- SWITCHES ----------
Event: Application_StartEvent
	Path: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|Application_StartEvent
	Condition: Time=StartTime
		StartTime: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|ProtocolSchemaItem|Start time(0 [min])
		Time: PBPK_model_human_Ab|Time(0 [min])
	Assignments:
		Path: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|Application rate
		UseAsValue: False
			Formula: DrugMass/InfusionTime
				DrugMass: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|ProtocolSchemaItem|DrugMass(0.584000000823388 [µmol])
				InfusionTime: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|ProtocolSchemaItem|Infusion time(30 [min])
				Time: PBPK_model_human_Ab|Time(0 [min])

Event: Application_StopEvent
	Path: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|Application_StopEvent
	Condition: Time=StartTime+InfusionTime
		InfusionTime: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|ProtocolSchemaItem|Infusion time(30 [min])
		StartTime: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|ProtocolSchemaItem|Start time(0 [min])
		Time: PBPK_model_human_Ab|Time(0 [min])
	Assignments:
		Path: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|Application rate
		UseAsValue: False
			Formula: 0

Event: Application_StartEvent
	Path: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|Application_StartEvent
	Condition: Time=StartTime
		StartTime: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|ProtocolSchemaItem|Start time(30 [min])
		Time: PBPK_model_human_Ab|Time(0 [min])
	Assignments:
		Path: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|Application rate
		UseAsValue: False
			Formula: DrugMass/InfusionTime
				DrugMass: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|ProtocolSchemaItem|DrugMass(9.14933334623307 [µmol])
				InfusionTime: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|ProtocolSchemaItem|Infusion time(150 [min])
				Time: PBPK_model_human_Ab|Time(0 [min])

Event: Application_StopEvent
	Path: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|Application_StopEvent
	Condition: Time=StartTime+InfusionTime
		InfusionTime: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|ProtocolSchemaItem|Infusion time(150 [min])
		StartTime: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|ProtocolSchemaItem|Start time(30 [min])
		Time: PBPK_model_human_Ab|Time(0 [min])
	Assignments:
		Path: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|Application rate
		UseAsValue: False
			Formula: 0

--------------- PARAMETER ----------
Parameter: PBPK_model_human_Ab|Organism|Surface area scaling exponent
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Volume (plasma)
	IsFixed: False
	Value: 2.94976831696389 [l]
	Formula: V_pls_art+V_pls_bon+V_pls_brn+V_pls_cae+V_pls_colasc+V_pls_coldesc+V_pls_colsigm+V_pls_coltrans+V_pls_duo+V_pls_fat+V_pls_tes+V_pls_hrt+V_pls_kid+V_pls_lin+V_pls_lil+V_pls_lje+V_pls_lng+V_pls_mus+V_pls_pan+V_pls_prc+V_pls_prp+V_pls_pve+V_pls_rect+V_pls_skn+V_pls_sin+V_pls_spl+V_pls_sto+V_pls_uil+V_pls_uje+V_pls_ven
		V_pls_art: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|Volume(0.222134387972578 [l])
		V_pls_bon: PBPK_model_human_Ab|Organism|Bone|Plasma|Volume(0.21297361860168 [l])
		V_pls_brn: PBPK_model_human_Ab|Organism|Brain|Plasma|Volume(0.0311943841534115 [l])
		V_pls_fat: PBPK_model_human_Ab|Organism|Fat|Plasma|Volume(0.139839566189771 [l])
		V_pls_tes: PBPK_model_human_Ab|Organism|Gonads|Plasma|Volume(0.00117384300516067 [l])
		V_pls_hrt: PBPK_model_human_Ab|Organism|Heart|Plasma|Volume(0.0309860416860081 [l])
		V_pls_kid: PBPK_model_human_Ab|Organism|Kidney|Plasma|Volume(0.0534462425234655 [l])
		V_pls_lin: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|Volume(0.00417957744745837 [l])
		V_pls_lng: PBPK_model_human_Ab|Organism|Lung|Plasma|Volume(0.373299674376007 [l])
		V_pls_mus: PBPK_model_human_Ab|Organism|Muscle|Plasma|Volume(0.432483065940599 [l])
		V_pls_pan: PBPK_model_human_Ab|Organism|Pancreas|Plasma|Volume(0.0201864473139155 [l])
		V_pls_pve: PBPK_model_human_Ab|Organism|PortalVein|Plasma|Volume(0.549841357705713 [l])
		V_pls_skn: PBPK_model_human_Ab|Organism|Skin|Plasma|Volume(0.0917406640016164 [l])
		V_pls_sin: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|Volume(0.00739430123772535 [l])
		V_pls_spl: PBPK_model_human_Ab|Organism|Spleen|Plasma|Volume(0.0361911749257049 [l])
		V_pls_sto: PBPK_model_human_Ab|Organism|Stomach|Plasma|Volume(0.00285851376261118 [l])
		V_pls_ven: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|Volume(0.510913940078214 [l])
		V_pls_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Volume(0.001129096160459 [l])
		V_pls_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Volume(0.00323155107993437 [l])
		V_pls_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Volume(0.00238797348878684 [l])
		V_pls_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Volume(0.00210245491947537 [l])
		V_pls_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Volume(0.00101229310937703 [l])
		V_pls_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|Volume(0.000457394928820579 [l])
		V_pls_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Volume(0.00083855740550307 [l])
		V_pls_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Volume(0.00176291491632691 [l])
		V_pls_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Volume(0.000881457458163453 [l])
		V_pls_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Volume(0.000708314028881347 [l])
		V_pls_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|Volume(0.000288572382136845 [l])
		V_pls_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|Volume(0.214130936164388 [l])
		V_pls_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Specific clearance (endosome)
	IsFixed: False
	Value: 0.2052 [1/min]
	Formula: K_uptake-K_rec>=0 ? K_uptake-K_rec : 0
		K_uptake: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])
		K_rec: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|SA proportionality factor
	IsFixed: False
	Value: 9500 [1/dm]
	Formula: 9500

Parameter: PBPK_model_human_Ab|Organism|Weight
	IsFixed: False
	Value: 73.0000001029235 [kg]
	Formula: M_art + M_sto + M_sin + M_lin + M_pan + M_spl + M_liv + M_lng + M_mus + M_fat + M_skn + M_kid + M_brn + M_hrt + M_bon + M_tes + M_pve + M_ven
		M_art: PBPK_model_human_Ab|Organism|ArterialBlood|Weight (tissue)(0.419121486740713 [kg])
		M_bon: PBPK_model_human_Ab|Organism|Bone|Weight (tissue)(11.8187357714584 [kg])
		M_brn: PBPK_model_human_Ab|Organism|Brain|Weight (tissue)(1.50916227157288 [kg])
		M_fat: PBPK_model_human_Ab|Organism|Fat|Weight (tissue)(14.6582354496615 [kg])
		M_tes: PBPK_model_human_Ab|Organism|Gonads|Weight (tissue)(0.0402690567808118 [kg])
		M_hrt: PBPK_model_human_Ab|Organism|Heart|Weight (tissue)(0.417601639973155 [kg])
		M_kid: PBPK_model_human_Ab|Organism|Kidney|Weight (tissue)(0.438443334893072 [kg])
		M_lin: PBPK_model_human_Ab|Organism|LargeIntestine|Weight (tissue)(0.412481964175021 [kg])
		M_liv: PBPK_model_human_Ab|Organism|Liver|Weight (tissue)(2.37659196630841 [kg])
		M_lng: PBPK_model_human_Ab|Organism|Lung|Weight (tissue)(1.21437760044244 [kg])
		M_mus: PBPK_model_human_Ab|Organism|Muscle|Weight (tissue)(32.6402313917433 [kg])
		M_pan: PBPK_model_human_Ab|Organism|Pancreas|Weight (tissue)(0.19043818220675 [kg])
		M_pve: PBPK_model_human_Ab|Organism|PortalVein|Weight (tissue)(1.03743652397304 [kg])
		M_skn: PBPK_model_human_Ab|Organism|Skin|Weight (tissue)(3.76294766208435 [kg])
		M_sin: PBPK_model_human_Ab|Organism|SmallIntestine|Weight (tissue)(0.724467834480575 [kg])
		M_spl: PBPK_model_human_Ab|Organism|Spleen|Weight (tissue)(0.206924956693567 [kg])
		M_sto: PBPK_model_human_Ab|Organism|Stomach|Weight (tissue)(0.168544443550188 [kg])
		M_ven: PBPK_model_human_Ab|Organism|VenousBlood|Weight (tissue)(0.963988566185309 [kg])

Parameter: PBPK_model_human_Ab|Organism|Estimated gestational age
	IsFixed: False
	Value: 1605.35714285714 [week(s)]
	Formula: Age* 365.25/7 + GA
		Age: PBPK_model_human_Ab|Organism|Age(30 [year(s)])
		GA: PBPK_model_human_Ab|Organism|Gestational age(40 [week(s)])

Parameter: PBPK_model_human_Ab|Organism|BMI
	IsFixed: False
	Value: 0.235666322646318 [kg/dm²]
	Formula: Height>0 ? BW / (Height)^2 : 0
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		BW: PBPK_model_human_Ab|Organism|Weight(73.0000001029235 [kg])

Parameter: PBPK_model_human_Ab|Organism|Vf (protein,blood cells)
	IsFixed: False
	Value: 0.325
	Formula: 0.325

Parameter: PBPK_model_human_Ab|Organism|Vf (protein,plasma)
	IsFixed: False
	Value: 0.067
	Formula: 0.067

Parameter: PBPK_model_human_Ab|Organism|Vf (water,interstitial)
	IsFixed: False
	Value: 0.935
	Formula: 0.935

Parameter: PBPK_model_human_Ab|Organism|Vf (lipid, blood cells)
	IsFixed: False
	Value: 0.005
	Formula: 0.005

Parameter: PBPK_model_human_Ab|Organism|Vf (water,blood cells)
	IsFixed: False
	Value: 0.625
	Formula: 0.625

Parameter: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)
	IsFixed: False
	Value: 0.37
	Formula: 0.37

Parameter: PBPK_model_human_Ab|Organism|Vf (neutral lipid, blood cells)-WS
	IsFixed: False
	Value: 0.003
	Formula: 0.003

Parameter: PBPK_model_human_Ab|Organism|Vf (lipid, plasma)
	IsFixed: False
	Value: 0.007
	Formula: 0.007

Parameter: PBPK_model_human_Ab|Organism|Vf (neutral lipid, plasma)-RR
	IsFixed: False
	Value: 0.0032
	Formula: 0.0032

Parameter: PBPK_model_human_Ab|Organism|Vf (water,plasma)
	IsFixed: False
	Value: 0.926
	Formula: 0.926

Parameter: PBPK_model_human_Ab|Organism|Scaling exponent for fluid recirculation flow rate
	IsFixed: False
	Value: 0.667
	Formula: 0.667

Parameter: PBPK_model_human_Ab|Organism|Thickness (endothelium)
	IsFixed: False
	Value: 3E-06 [dm]
	Formula: 3E-06

Parameter: PBPK_model_human_Ab|Organism|pH (plasma)
	IsFixed: False
	Value: 7.4
	Formula: 7.4

Parameter: PBPK_model_human_Ab|Organism|pH (intracellular)
	IsFixed: False
	Value: 7
	Formula: 7

Parameter: PBPK_model_human_Ab|Organism|pH (interstitial)
	IsFixed: False
	Value: 7.4
	Formula: 7.4

Parameter: PBPK_model_human_Ab|Organism|pH (blood cells)
	IsFixed: False
	Value: 7.22
	Formula: 7.22

Parameter: PBPK_model_human_Ab|Organism|Gestational age
	IsFixed: False
	Value: 40 [week(s)]
	Formula: 40

Parameter: PBPK_model_human_Ab|Organism|Age
	IsFixed: False
	Value: 30 [year(s)]
	Formula: 30

Parameter: PBPK_model_human_Ab|Organism|R*T
	IsFixed: False
	Value: 928.8 [(kg*dm/min²)*dm/µmol]
	Formula: 928.8

Parameter: PBPK_model_human_Ab|Organism|Na
	IsFixed: False
	Value: 6.022E+17 [1/µmol]
	Formula: 6.022E+17

Parameter: PBPK_model_human_Ab|Organism|Fraction endosomal (global)
	IsFixed: False
	Value: 0.2
	Formula: 0.2

Parameter: PBPK_model_human_Ab|Organism|Vf (neutral phospholipid, plasma)-RR
	IsFixed: False
	Value: 0.0021
	Formula: 0.0021

Parameter: PBPK_model_human_Ab|Organism|Vf (neutral phospholipid, blood cells)-WS
	IsFixed: False
	Value: 0.0059
	Formula: 0.0059

Parameter: PBPK_model_human_Ab|Organism|Vf (neutral lipid, plasma)-PT
	IsFixed: False
	Value: 0.0035
	Formula: 0.0035

Parameter: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)
	IsFixed: False
	Value: 167000 [1/dm]
	Formula: 167000

Parameter: PBPK_model_human_Ab|Organism|Vf (acidic phospholipids, blood cells)-WS
	IsFixed: False
	Value: 0.001
	Formula: 0.001

Parameter: PBPK_model_human_Ab|Organism|Vf (neutral lipid, blood cells)-RR
	IsFixed: False
	Value: 0.0012
	Formula: 0.0012

Parameter: PBPK_model_human_Ab|Organism|Vf (phospholipid, plasma)-PT
	IsFixed: False
	Value: 0.00225
	Formula: 0.00225

Parameter: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Ontogeny factor (albumin)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Height
	IsFixed: False
	Value: 17.6 [dm]
	Formula: 17.6

Parameter: PBPK_model_human_Ab|Organism|Ontogeny factor (alpha1-acid glycoprotein)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Plasma protein scale factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Vf (water,plasma)-PT
	IsFixed: False
	Value: 0.945
	Formula: 0.945

Parameter: PBPK_model_human_Ab|Organism|Vf (neutral phospholipid, blood cells)-RR
	IsFixed: False
	Value: 0.0033
	Formula: 0.0033

Parameter: PBPK_model_human_Ab|Organism|Acidic phospholipids (blood cells) [mg/g] - RR
	IsFixed: False
	Value: 0.57
	Formula: 0.57

Parameter: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Vf (intracellular water, blood cells)-RR
	IsFixed: False
	Value: 0.63
	Formula: 0.63

Parameter: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: 0.294

Parameter: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: 0.0888

Parameter: PBPK_model_human_Ab|Organism|Hematocrit
	IsFixed: False
	Value: 0.47
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|MeanBW
	IsFixed: False
	Value: 73 [kg]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|MeanHeight
	IsFixed: False
	Value: 17.6 [dm]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|VenousBlood|Weight (tissue)
	IsFixed: False
	Value: 0.963988566185309 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|VenousBlood|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|VenousBlood|Volume(0.963988566185309 [l])

Parameter: PBPK_model_human_Ab|Organism|VenousBlood|Allometric scale factor
	IsFixed: False
	Value: 0.75
	Formula: 0.75

Parameter: PBPK_model_human_Ab|Organism|VenousBlood|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|VenousBlood|Fraction vascular
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|VenousBlood|Volume
	IsFixed: False
	Value: 0.963988566185309 [l]
	Percentile: 0.500859582308646

Parameter: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.510913940078214 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|Volume(0.510913940078214 [l])

Parameter: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|Volume
	IsFixed: False
	Value: 0.510913940078214 [l]
	Formula: (1-HCT)*V
		f_vas: PBPK_model_human_Ab|Organism|VenousBlood|Fraction vascular(1)
		V: PBPK_model_human_Ab|Organism|VenousBlood|Volume(0.963988566185309 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|Volume(0.510913940078214 [l])

Parameter: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.453074626107095 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|Volume(0.453074626107095 [l])

Parameter: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|Volume
	IsFixed: False
	Value: 0.453074626107095 [l]
	Formula: HCT*V
		V: PBPK_model_human_Ab|Organism|VenousBlood|Volume(0.963988566185309 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|Volume(0.453074626107095 [l])

Parameter: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|ArterialBlood|Weight (tissue)
	IsFixed: False
	Value: 0.419121486740713 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|ArterialBlood|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|ArterialBlood|Volume(0.419121486740713 [l])

Parameter: PBPK_model_human_Ab|Organism|ArterialBlood|Allometric scale factor
	IsFixed: False
	Value: 0.75
	Formula: 0.75

Parameter: PBPK_model_human_Ab|Organism|ArterialBlood|Peripheral blood flow fraction
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|Organism|ArterialBlood|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|ArterialBlood|Fraction vascular
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|ArterialBlood|Volume
	IsFixed: False
	Value: 0.419121486740713 [l]
	Percentile: 0.500783874398467

Parameter: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.222134387972578 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|Volume(0.222134387972578 [l])

Parameter: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|Volume
	IsFixed: False
	Value: 0.222134387972578 [l]
	Formula: (1-HCT)*V
		f_vas: PBPK_model_human_Ab|Organism|ArterialBlood|Fraction vascular(1)
		V: PBPK_model_human_Ab|Organism|ArterialBlood|Volume(0.419121486740713 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|Volume(0.222134387972578 [l])

Parameter: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.196987098768135 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|Volume(0.196987098768135 [l])

Parameter: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|Volume
	IsFixed: False
	Value: 0.196987098768135 [l]
	Formula: HCT*V
		V: PBPK_model_human_Ab|Organism|ArterialBlood|Volume(0.419121486740713 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|Volume(0.196987098768135 [l])

Parameter: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|Bone|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Bone|Weight (tissue)
	IsFixed: False
	Value: 11.8187357714584 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|Bone|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|Bone|Volume(11.8187357714584 [l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Bone|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Bone|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Bone|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|Bone|Blood flow rate
	IsFixed: False
	Value: 0.324956140036248 [l/min]
	Formula: Qspec * Weight
		Qspec: PBPK_model_human_Ab|Organism|Bone|Specific blood flow rate(0.027495 [l/min/kg organ])
		Weight: PBPK_model_human_Ab|Organism|Bone|Weight (tissue)(11.8187357714584 [kg])

Parameter: PBPK_model_human_Ab|Organism|Bone|Volume (endothelium)
	IsFixed: False
	Value: 0.0114523549625432 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)(3817.45165418105 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Bone|Lymph flow rate
	IsFixed: False
	Value: 0.000114014111293118 [l/min]
	Formula: f_lymph*Q*(1-HCT)
		Q: PBPK_model_human_Ab|Organism|Bone|Blood flow rate(0.324956140036248 [l/min])
		f_lymph: PBPK_model_human_Ab|Organism|Bone|Lymph flow proportionality factor(0.000662)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Bone|Fluid recirculation flow rate
	IsFixed: False
	Value: 5.33261345230804E-06 [l/min]
	Formula: f_Jiso * (1-alpha_l) * Q_lymph * (V/V_mouse)^(exp_Jiso_scale - 1)
		alpha_l: PBPK_model_human_Ab|Organism|Bone|Flow fraction via large pores(0.05)
		f_Jiso: PBPK_model_human_Ab|Organism|Bone|Fluid recirculation flow proportionality factor(0.96)
		Q_lymph: PBPK_model_human_Ab|Organism|Bone|Lymph flow rate(0.000114014111293118 [l/min])
		V_mouse: PBPK_model_human_Ab|Organism|Bone|Organ volume mouse(0.00158 [l])
		V: PBPK_model_human_Ab|Organism|Bone|Volume(11.8187357714584 [l])
		exp_Jiso_scale: PBPK_model_human_Ab|Organism|Scaling exponent for fluid recirculation flow rate(0.667)

Parameter: PBPK_model_human_Ab|Organism|Bone|Fraction intracellular
	IsFixed: False
	Value: 0.866
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|Bone|Fraction interstitial(0.1)
		f_vas: PBPK_model_human_Ab|Organism|Bone|Fraction vascular(0.034)

Parameter: PBPK_model_human_Ab|Organism|Bone|Lymph flow proportionality factor
	IsFixed: False
	Value: 0.000662
	Formula: 0.000662

Parameter: PBPK_model_human_Ab|Organism|Bone|Organ volume mouse
	IsFixed: False
	Value: 0.00158 [l]
	Formula: 0.00158

Parameter: PBPK_model_human_Ab|Organism|Bone|Fluid recirculation flow proportionality factor
	IsFixed: False
	Value: 0.96
	Formula: 0.96

Parameter: PBPK_model_human_Ab|Organism|Bone|Allometric scale factor
	IsFixed: False
	Value: 2
	Formula: 2

Parameter: PBPK_model_human_Ab|Organism|Bone|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Bone|Peripheral blood flow fraction
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|Organism|Bone|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Bone|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|Bone|Hydraulic conductivity
	IsFixed: False
	Value: 9E-12 [l/min/(kg*dm/min²)]
	Formula: 9E-12

Parameter: PBPK_model_human_Ab|Organism|Bone|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|Bone|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|Bone|Vf (lipid)
	IsFixed: False
	Value: 0.268
	Formula: 0.268

Parameter: PBPK_model_human_Ab|Organism|Bone|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.074
	Formula: 0.074

Parameter: PBPK_model_human_Ab|Organism|Bone|Fraction vascular
	IsFixed: False
	Value: 0.034
	Formula: 0.034

Parameter: PBPK_model_human_Ab|Organism|Bone|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0011
	Formula: 0.0011

Parameter: PBPK_model_human_Ab|Organism|Bone|Vf (protein)
	IsFixed: False
	Value: 0.268
	Formula: 0.268

Parameter: PBPK_model_human_Ab|Organism|Bone|Vf (water)
	IsFixed: False
	Value: 0.465
	Formula: 0.465

Parameter: PBPK_model_human_Ab|Organism|Bone|Vf (water)-PT
	IsFixed: False
	Value: 0.439
	Formula: 0.439

Parameter: PBPK_model_human_Ab|Organism|Bone|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|Bone|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|Bone|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.1
	Formula: 0.1

Parameter: PBPK_model_human_Ab|Organism|Bone|Fraction interstitial
	IsFixed: False
	Value: 0.1
	Formula: 0.1

Parameter: PBPK_model_human_Ab|Organism|Bone|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0174
	Formula: 0.0174

Parameter: PBPK_model_human_Ab|Organism|Bone|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.017
	Formula: 0.017

Parameter: PBPK_model_human_Ab|Organism|Bone|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0022
	Formula: 0.0022

Parameter: PBPK_model_human_Ab|Organism|Bone|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0016
	Formula: 0.0016

Parameter: PBPK_model_human_Ab|Organism|Bone|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.1
	Formula: 0.1

Parameter: PBPK_model_human_Ab|Organism|Bone|Vf (protein)-WS
	IsFixed: False
	Value: 0.21
	Formula: 0.21

Parameter: PBPK_model_human_Ab|Organism|Bone|Vf (water)-WS
	IsFixed: False
	Value: 0.26
	Formula: 0.26

Parameter: PBPK_model_human_Ab|Organism|Bone|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.317
	Formula: 0.317

Parameter: PBPK_model_human_Ab|Organism|Bone|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0008
	Formula: 0.0008

Parameter: PBPK_model_human_Ab|Organism|Bone|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 0.67
	Formula: 0.67

Parameter: PBPK_model_human_Ab|Organism|Bone|Specific blood flow rate
	IsFixed: False
	Value: 0.027495 [l/min/kg organ]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Bone|Volume
	IsFixed: False
	Value: 11.8187357714584 [l]
	Percentile: 0.502770573008906

Parameter: PBPK_model_human_Ab|Organism|Bone|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.21297361860168 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Bone|Plasma|Volume(0.21297361860168 [l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Plasma|Volume
	IsFixed: False
	Value: 0.21297361860168 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|Bone|Fraction vascular(0.034)
		V_org: PBPK_model_human_Ab|Organism|Bone|Volume(11.8187357714584 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Bone|Plasma|Volume(0.21297361860168 [l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Bone|Plasma|Volume(0.21297361860168 [l])

Parameter: PBPK_model_human_Ab|Organism|Bone|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.188863397627905 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Bone|BloodCells|Volume(0.188863397627905 [l])

Parameter: PBPK_model_human_Ab|Organism|Bone|BloodCells|Volume
	IsFixed: False
	Value: 0.188863397627905 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|Bone|Fraction vascular(0.034)
		V: PBPK_model_human_Ab|Organism|Bone|Volume(11.8187357714584 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Bone|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Bone|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Bone|BloodCells|Volume(0.188863397627905 [l])

Parameter: PBPK_model_human_Ab|Organism|Bone|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|Bone|Interstitial|Volume of protein container
	IsFixed: False
	Value: 1.18187357714584 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Bone|Interstitial|Volume(1.18187357714584 [l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Interstitial|Volume
	IsFixed: False
	Value: 1.18187357714584 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|Bone|Fraction interstitial(0.1)
		V: PBPK_model_human_Ab|Organism|Bone|Volume(11.8187357714584 [l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Bone|Interstitial|Volume(1.18187357714584 [l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Bone|Interstitial|Volume(1.18187357714584 [l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Intracellular|Volume of protein container
	IsFixed: False
	Value: 11.8187357714584 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Bone|Volume(11.8187357714584 [l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Intracellular|Volume
	IsFixed: False
	Value: 10.2350251780829 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|Bone|Fraction intracellular(0.866)
		V: PBPK_model_human_Ab|Organism|Bone|Volume(11.8187357714584 [l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Intracellular|pH
	IsFixed: False
	Value: 7
	Formula: 7

Parameter: PBPK_model_human_Ab|Organism|Bone|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Bone|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Bone|Intracellular|Volume(10.2350251780829 [l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.96634360525929
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|Partition coefficient (intracellular/water)(1.96634360525929)

Parameter: PBPK_model_human_Ab|Organism|Bone|Endosome|Volume of protein container
	IsFixed: False
	Value: 0.00229047099250863 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Bone|Endosome|Volume(0.00229047099250863 [l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Endosome|Volume
	IsFixed: False
	Value: 0.00229047099250863 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|Bone|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)(3817.45165418105 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Bone|Endosome|Volume(0.00229047099250863 [l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Bone|Endosome|Volume(0.00229047099250863 [l])

Parameter: PBPK_model_human_Ab|Organism|Gallbladder|Time to complete gallbladder refilling
	IsFixed: False
	Value: 118.2 [min]
	Formula: 6*EHC_HalfTime
		EHC_HalfTime: PBPK_model_human_Ab|Organism|Gallbladder|Gallbladder ejection half-time(19.7 [min])
		Time: PBPK_model_human_Ab|Time(0 [min])

Parameter: PBPK_model_human_Ab|Organism|Gallbladder|Gallbladder emptying active
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|Organism|Gallbladder|Volume
	IsFixed: False
	Value: 1 [l]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Gallbladder|Gallbladder ejection half-time
	IsFixed: False
	Value: 19.7 [min]
	Formula: 19.7

Parameter: PBPK_model_human_Ab|Organism|Gallbladder|Gallbladder ejection fraction
	IsFixed: False
	Value: 0.65
	Formula: 0.65

Parameter: PBPK_model_human_Ab|Organism|Gallbladder|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Gallbladder|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Gallbladder|Volume(1 [l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Brain|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Brain|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Brain|Weight (tissue)
	IsFixed: False
	Value: 1.50916227157288 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|Brain|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|Brain|Volume(1.50916227157288 [l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|Brain|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Brain|Lymph flow rate
	IsFixed: False
	Value: 3.00487703953774E-05 [l/min]
	Formula: f_lymph*Q*(1-HCT)
		Q: PBPK_model_human_Ab|Organism|Brain|Blood flow rate(0.779859603835287 [l/min])
		f_lymph: PBPK_model_human_Ab|Organism|Brain|Lymph flow proportionality factor(7.27E-05)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Brain|Fluid recirculation flow rate
	IsFixed: False
	Value: 5.58665816421524E-07 [l/min]
	Formula: f_Jiso * (1-alpha_l) * Q_lymph * (V/V_mouse)^(exp_Jiso_scale - 1)
		alpha_l: PBPK_model_human_Ab|Organism|Brain|Flow fraction via large pores(0.05)
		f_Jiso: PBPK_model_human_Ab|Organism|Brain|Fluid recirculation flow proportionality factor(0.404)
		Q_lymph: PBPK_model_human_Ab|Organism|Brain|Lymph flow rate(3.00487703953774E-05 [l/min])
		V_mouse: PBPK_model_human_Ab|Organism|Brain|Organ volume mouse(0.00017 [l])
		V: PBPK_model_human_Ab|Organism|Brain|Volume(1.50916227157288 [l])
		exp_Jiso_scale: PBPK_model_human_Ab|Organism|Scaling exponent for fluid recirculation flow rate(0.667)

Parameter: PBPK_model_human_Ab|Organism|Brain|Volume (endothelium)
	IsFixed: False
	Value: 0.00167743386485326 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|Surface area (plasma/interstitial)(559.144621617753 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Brain|Fraction intracellular
	IsFixed: False
	Value: 0.957
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|Brain|Fraction interstitial(0.004)
		f_vas: PBPK_model_human_Ab|Organism|Brain|Fraction vascular(0.039)

Parameter: PBPK_model_human_Ab|Organism|Brain|Blood flow rate
	IsFixed: False
	Value: 0.779859603835287 [l/min]
	Formula: Qspec * Weight
		Qspec: PBPK_model_human_Ab|Organism|Brain|Specific blood flow rate(0.51675 [l/min/kg organ])
		Weight: PBPK_model_human_Ab|Organism|Brain|Weight (tissue)(1.50916227157288 [kg])

Parameter: PBPK_model_human_Ab|Organism|Brain|Lymph flow proportionality factor
	IsFixed: False
	Value: 7.27E-05
	Formula: 7.27E-05

Parameter: PBPK_model_human_Ab|Organism|Brain|Organ volume mouse
	IsFixed: False
	Value: 0.00017 [l]
	Formula: 0.00017

Parameter: PBPK_model_human_Ab|Organism|Brain|Fluid recirculation flow proportionality factor
	IsFixed: False
	Value: 0.404
	Formula: 0.404

Parameter: PBPK_model_human_Ab|Organism|Brain|Allometric scale factor
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|Organism|Brain|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Brain|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Brain|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|Brain|Hydraulic conductivity
	IsFixed: False
	Value: 5E-14 [l/min/(kg*dm/min²)]
	Formula: 5E-14

Parameter: PBPK_model_human_Ab|Organism|Brain|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|Brain|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|Brain|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.051
	Formula: 0.051

Parameter: PBPK_model_human_Ab|Organism|Brain|Vf (lipid)
	IsFixed: False
	Value: 0.11
	Formula: 0.11

Parameter: PBPK_model_human_Ab|Organism|Brain|Fraction vascular
	IsFixed: False
	Value: 0.039
	Formula: 0.039

Parameter: PBPK_model_human_Ab|Organism|Brain|Vf (protein)
	IsFixed: False
	Value: 0.081
	Formula: 0.081

Parameter: PBPK_model_human_Ab|Organism|Brain|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0565
	Formula: 0.0565

Parameter: PBPK_model_human_Ab|Organism|Brain|Vf (water)
	IsFixed: False
	Value: 0.808
	Formula: 0.808

Parameter: PBPK_model_human_Ab|Organism|Brain|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.048
	Formula: 0.048

Parameter: PBPK_model_human_Ab|Organism|Brain|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|Brain|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.041
	Formula: 0.041

Parameter: PBPK_model_human_Ab|Organism|Brain|Vf (water)-PT
	IsFixed: False
	Value: 0.77
	Formula: 0.77

Parameter: PBPK_model_human_Ab|Organism|Brain|Fraction interstitial
	IsFixed: False
	Value: 0.004
	Formula: 0.004

Parameter: PBPK_model_human_Ab|Organism|Brain|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0429
	Formula: 0.0429

Parameter: PBPK_model_human_Ab|Organism|Brain|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0391
	Formula: 0.0391

Parameter: PBPK_model_human_Ab|Organism|Brain|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0528
	Formula: 0.0528

Parameter: PBPK_model_human_Ab|Organism|Brain|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0015
	Formula: 0.0015

Parameter: PBPK_model_human_Ab|Organism|Brain|Vf (protein)-WS
	IsFixed: False
	Value: 0.08
	Formula: 0.08

Parameter: PBPK_model_human_Ab|Organism|Brain|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.162
	Formula: 0.162

Parameter: PBPK_model_human_Ab|Organism|Brain|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.591
	Formula: 0.591

Parameter: PBPK_model_human_Ab|Organism|Brain|Vf (water)-WS
	IsFixed: False
	Value: 0.79
	Formula: 0.79

Parameter: PBPK_model_human_Ab|Organism|Brain|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0143
	Formula: 0.0143

Parameter: PBPK_model_human_Ab|Organism|Brain|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 0.4
	Formula: 0.4

Parameter: PBPK_model_human_Ab|Organism|Brain|Volume
	IsFixed: False
	Value: 1.50916227157288 [l]
	Percentile: 0.50191572963298

Parameter: PBPK_model_human_Ab|Organism|Brain|Specific blood flow rate
	IsFixed: False
	Value: 0.51675 [l/min/kg organ]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Brain|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.0311943841534115 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Brain|Plasma|Volume(0.0311943841534115 [l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Plasma|Volume
	IsFixed: False
	Value: 0.0311943841534115 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|Brain|Fraction vascular(0.039)
		V_org: PBPK_model_human_Ab|Organism|Brain|Volume(1.50916227157288 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Brain|Plasma|Volume(0.0311943841534115 [l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Brain|Plasma|Volume(0.0311943841534115 [l])

Parameter: PBPK_model_human_Ab|Organism|Brain|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.0276629444379309 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Brain|BloodCells|Volume(0.0276629444379309 [l])

Parameter: PBPK_model_human_Ab|Organism|Brain|BloodCells|Volume
	IsFixed: False
	Value: 0.0276629444379309 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|Brain|Fraction vascular(0.039)
		V: PBPK_model_human_Ab|Organism|Brain|Volume(1.50916227157288 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Brain|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Brain|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Brain|BloodCells|Volume(0.0276629444379309 [l])

Parameter: PBPK_model_human_Ab|Organism|Brain|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|Brain|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.00603664908629153 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Brain|Interstitial|Volume(0.00603664908629153 [l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Interstitial|Volume
	IsFixed: False
	Value: 0.00603664908629153 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|Brain|Fraction interstitial(0.004)
		V: PBPK_model_human_Ab|Organism|Brain|Volume(1.50916227157288 [l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Brain|Interstitial|Volume(0.00603664908629153 [l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Brain|Interstitial|Volume(0.00603664908629153 [l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Intracellular|Volume of protein container
	IsFixed: False
	Value: 1.50916227157288 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Brain|Volume(1.50916227157288 [l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Intracellular|Volume
	IsFixed: False
	Value: 1.44426829389525 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|Brain|Fraction intracellular(0.957)
		V: PBPK_model_human_Ab|Organism|Brain|Volume(1.50916227157288 [l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Intracellular|pH
	IsFixed: False
	Value: 7.1
	Formula: 7.1

Parameter: PBPK_model_human_Ab|Organism|Brain|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Brain|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Brain|Intracellular|Volume(1.44426829389525 [l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.2177816930632
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|Partition coefficient (intracellular/water)(1.2177816930632)

Parameter: PBPK_model_human_Ab|Organism|Brain|Endosome|Volume of protein container
	IsFixed: False
	Value: 0.000335486772970652 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Brain|Endosome|Volume(0.000335486772970652 [l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Endosome|Volume
	IsFixed: False
	Value: 0.000335486772970652 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|Brain|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|Surface area (plasma/interstitial)(559.144621617753 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Brain|Endosome|Volume(0.000335486772970652 [l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Brain|Endosome|Volume(0.000335486772970652 [l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Fat|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Fat|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Fat|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|Fat|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Fat|Weight (tissue)
	IsFixed: False
	Value: 14.6582354496615 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|Fat|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|Fat|Volume(14.6582354496615 [l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Lymph flow rate
	IsFixed: False
	Value: 0.00127932693260599 [l/min]
	Formula: f_lymph*Q*(1-HCT)
		Q: PBPK_model_human_Ab|Organism|Fat|Blood flow rate(0.320135862220607 [l/min])
		f_lymph: PBPK_model_human_Ab|Organism|Fat|Lymph flow proportionality factor(0.00754)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Fat|Volume (endothelium)
	IsFixed: False
	Value: 0.00751967478567634 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|Surface area (plasma/interstitial)(2506.55826189211 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Fat|Fluid recirculation flow rate
	IsFixed: False
	Value: 1.77855852400894E-05 [l/min]
	Formula: f_Jiso * (1-alpha_l) * Q_lymph * (V/V_mouse)^(exp_Jiso_scale - 1)
		alpha_l: PBPK_model_human_Ab|Organism|Fat|Flow fraction via large pores(0.05)
		f_Jiso: PBPK_model_human_Ab|Organism|Fat|Fluid recirculation flow proportionality factor(0.357)
		Q_lymph: PBPK_model_human_Ab|Organism|Fat|Lymph flow rate(0.00127932693260599 [l/min])
		V_mouse: PBPK_model_human_Ab|Organism|Fat|Organ volume mouse(0.001 [l])
		V: PBPK_model_human_Ab|Organism|Fat|Volume(14.6582354496615 [l])
		exp_Jiso_scale: PBPK_model_human_Ab|Organism|Scaling exponent for fluid recirculation flow rate(0.667)

Parameter: PBPK_model_human_Ab|Organism|Fat|Fraction intracellular
	IsFixed: False
	Value: 0.822
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|Fat|Fraction interstitial(0.16)
		f_vas: PBPK_model_human_Ab|Organism|Fat|Fraction vascular(0.018)

Parameter: PBPK_model_human_Ab|Organism|Fat|Blood flow rate
	IsFixed: False
	Value: 0.320135862220607 [l/min]
	Formula: Qspec * Weight
		Qspec: PBPK_model_human_Ab|Organism|Fat|Specific blood flow rate(0.02184 [l/min/kg organ])
		Weight: PBPK_model_human_Ab|Organism|Fat|Weight (tissue)(14.6582354496615 [kg])

Parameter: PBPK_model_human_Ab|Organism|Fat|Lymph flow proportionality factor
	IsFixed: False
	Value: 0.00754
	Formula: 0.00754

Parameter: PBPK_model_human_Ab|Organism|Fat|Organ volume mouse
	IsFixed: False
	Value: 0.001 [l]
	Formula: 0.001

Parameter: PBPK_model_human_Ab|Organism|Fat|Fluid recirculation flow proportionality factor
	IsFixed: False
	Value: 0.357
	Formula: 0.357

Parameter: PBPK_model_human_Ab|Organism|Fat|Allometric scale factor
	IsFixed: False
	Value: 2
	Formula: 2

Parameter: PBPK_model_human_Ab|Organism|Fat|Peripheral blood flow fraction
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|Organism|Fat|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Fat|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Fat|Hydraulic conductivity
	IsFixed: False
	Value: 9E-12 [l/min/(kg*dm/min²)]
	Formula: 9E-12

Parameter: PBPK_model_human_Ab|Organism|Fat|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|Fat|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|Fat|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|Fat|Fraction vascular
	IsFixed: False
	Value: 0.018
	Formula: 0.018

Parameter: PBPK_model_human_Ab|Organism|Fat|Vf (protein)
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|Fat|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.049
	Formula: 0.049

Parameter: PBPK_model_human_Ab|Organism|Fat|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|Organism|Fat|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.068
	Formula: 0.068

Parameter: PBPK_model_human_Ab|Organism|Fat|Vf (protein)-WS
	IsFixed: False
	Value: 0.06
	Formula: 0.06

Parameter: PBPK_model_human_Ab|Organism|Fat|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.000552
	Formula: 0.000552

Parameter: PBPK_model_human_Ab|Organism|Fat|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 0.4
	Formula: 0.4

Parameter: PBPK_model_human_Ab|Organism|Fat|Volume
	IsFixed: False
	Value: 14.6582354496615 [l]
	Percentile: 0.48602247246561

Parameter: PBPK_model_human_Ab|Organism|Fat|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.79
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Fat|Vf (lipid)
	IsFixed: False
	Value: 0.8
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Fat|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.002
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Fat|Fraction interstitial
	IsFixed: False
	Value: 0.16
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Fat|Vf (water)-PT
	IsFixed: False
	Value: 0.18
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Fat|Vf (water)
	IsFixed: False
	Value: 0.15
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Fat|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.92
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Fat|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.853
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Fat|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.002024
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Fat|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0016
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Fat|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.135
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Fat|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.00899999999999998
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Fat|Vf (water)-WS
	IsFixed: False
	Value: 0.03
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Fat|Specific blood flow rate
	IsFixed: False
	Value: 0.02184 [l/min/kg organ]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Fat|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.139839566189771 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Fat|Plasma|Volume(0.139839566189771 [l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Plasma|Volume
	IsFixed: False
	Value: 0.139839566189771 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|Fat|Fraction vascular(0.018)
		V_org: PBPK_model_human_Ab|Organism|Fat|Volume(14.6582354496615 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Fat|Plasma|Volume(0.139839566189771 [l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Fat|Plasma|Volume(0.139839566189771 [l])

Parameter: PBPK_model_human_Ab|Organism|Fat|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.124008671904136 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Fat|BloodCells|Volume(0.124008671904136 [l])

Parameter: PBPK_model_human_Ab|Organism|Fat|BloodCells|Volume
	IsFixed: False
	Value: 0.124008671904136 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|Fat|Fraction vascular(0.018)
		V: PBPK_model_human_Ab|Organism|Fat|Volume(14.6582354496615 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Fat|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Fat|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Fat|BloodCells|Volume(0.124008671904136 [l])

Parameter: PBPK_model_human_Ab|Organism|Fat|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|Fat|Interstitial|Volume of protein container
	IsFixed: False
	Value: 2.34531767194584 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Fat|Interstitial|Volume(2.34531767194584 [l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Interstitial|Volume
	IsFixed: False
	Value: 2.34531767194584 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|Fat|Fraction interstitial(0.16)
		V: PBPK_model_human_Ab|Organism|Fat|Volume(14.6582354496615 [l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Fat|Interstitial|Volume(2.34531767194584 [l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Fat|Interstitial|Volume(2.34531767194584 [l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Intracellular|Volume of protein container
	IsFixed: False
	Value: 14.6582354496615 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Fat|Volume(14.6582354496615 [l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Intracellular|Volume
	IsFixed: False
	Value: 12.0490695396217 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|Fat|Fraction intracellular(0.822)
		V: PBPK_model_human_Ab|Organism|Fat|Volume(14.6582354496615 [l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Intracellular|pH
	IsFixed: False
	Value: 7.1
	Formula: 7.1

Parameter: PBPK_model_human_Ab|Organism|Fat|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Fat|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Fat|Intracellular|Volume(12.0490695396217 [l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 6.3237501733623
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|Partition coefficient (intracellular/water)(6.3237501733623)

Parameter: PBPK_model_human_Ab|Organism|Fat|Endosome|Volume of protein container
	IsFixed: False
	Value: 0.00150393495713527 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Fat|Endosome|Volume(0.00150393495713527 [l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Endosome|Volume
	IsFixed: False
	Value: 0.00150393495713527 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|Fat|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|Surface area (plasma/interstitial)(2506.55826189211 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Fat|Endosome|Volume(0.00150393495713527 [l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Fat|Endosome|Volume(0.00150393495713527 [l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Gonads|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Gonads|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|Gonads|Weight (tissue)
	IsFixed: False
	Value: 0.0402690567808118 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|Gonads|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|Gonads|Volume(0.0402690567808118 [l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Fluid recirculation flow rate
	IsFixed: False
	Value: 3.20596453218297E-06 [l/min]
	Formula: f_Jiso * (1-alpha_l) * Q_lymph * (V/V_mouse)^(exp_Jiso_scale - 1)
		alpha_l: PBPK_model_human_Ab|Organism|Gonads|Flow fraction via large pores(0.05)
		f_Jiso: PBPK_model_human_Ab|Organism|Gonads|Fluid recirculation flow proportionality factor(0.96)
		Q_lymph: PBPK_model_human_Ab|Organism|Gonads|Lymph flow rate(1.90943705999462E-05 [l/min])
		V_mouse: PBPK_model_human_Ab|Organism|Gonads|Organ volume mouse(0.00025 [l])
		V: PBPK_model_human_Ab|Organism|Gonads|Volume(0.0402690567808118 [l])
		exp_Jiso_scale: PBPK_model_human_Ab|Organism|Scaling exponent for fluid recirculation flow rate(0.667)

Parameter: PBPK_model_human_Ab|Organism|Gonads|Lymph flow rate
	IsFixed: False
	Value: 1.90943705999462E-05 [l/min]
	Formula: f_lymph*Q*(1-HCT)
		Q: PBPK_model_human_Ab|Organism|Gonads|Blood flow rate(0.00324568597653343 [l/min])
		f_lymph: PBPK_model_human_Ab|Organism|Gonads|Lymph flow proportionality factor(0.0111)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Gonads|Volume (endothelium)
	IsFixed: False
	Value: 6.31217465039226E-05 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|Surface area (plasma/interstitial)(21.0405821679742 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Fraction intracellular
	IsFixed: False
	Value: 0.876
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|Gonads|Fraction interstitial(0.069)
		f_vas: PBPK_model_human_Ab|Organism|Gonads|Fraction vascular(0.055)

Parameter: PBPK_model_human_Ab|Organism|Gonads|Blood flow rate
	IsFixed: False
	Value: 0.00324568597653343 [l/min]
	Formula: Qspec * Weight
		Qspec: PBPK_model_human_Ab|Organism|Gonads|Specific blood flow rate(0.0806 [l/min/kg organ])
		Weight: PBPK_model_human_Ab|Organism|Gonads|Weight (tissue)(0.0402690567808118 [kg])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Lymph flow proportionality factor
	IsFixed: False
	Value: 0.0111
	Formula: 0.0111

Parameter: PBPK_model_human_Ab|Organism|Gonads|Organ volume mouse
	IsFixed: False
	Value: 0.00025 [l]
	Formula: 0.00025

Parameter: PBPK_model_human_Ab|Organism|Gonads|Fluid recirculation flow proportionality factor
	IsFixed: False
	Value: 0.96
	Formula: 0.96

Parameter: PBPK_model_human_Ab|Organism|Gonads|Allometric scale factor
	IsFixed: False
	Value: 0.75
	Formula: 0.75

Parameter: PBPK_model_human_Ab|Organism|Gonads|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Gonads|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Gonads|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|Gonads|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|Gonads|Hydraulic conductivity
	IsFixed: False
	Value: 9E-12 [l/min/(kg*dm/min²)]
	Formula: 9E-12

Parameter: PBPK_model_human_Ab|Organism|Gonads|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|Gonads|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0048
	Formula: 0.0048

Parameter: PBPK_model_human_Ab|Organism|Gonads|Vf (lipid)
	IsFixed: False
	Value: 0.031
	Formula: 0.031

Parameter: PBPK_model_human_Ab|Organism|Gonads|Fraction vascular
	IsFixed: False
	Value: 0.055
	Formula: 0.055

Parameter: PBPK_model_human_Ab|Organism|Gonads|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.01405
	Formula: 0.01405

Parameter: PBPK_model_human_Ab|Organism|Gonads|Vf (protein)
	IsFixed: False
	Value: 0.12
	Formula: 0.12

Parameter: PBPK_model_human_Ab|Organism|Gonads|Vf (water)-PT
	IsFixed: False
	Value: 0.8
	Formula: 0.8

Parameter: PBPK_model_human_Ab|Organism|Gonads|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|Gonads|Vf (water)
	IsFixed: False
	Value: 0.8
	Formula: 0.8

Parameter: PBPK_model_human_Ab|Organism|Gonads|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.048
	Formula: 0.048

Parameter: PBPK_model_human_Ab|Organism|Gonads|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.041
	Formula: 0.041

Parameter: PBPK_model_human_Ab|Organism|Gonads|Fraction interstitial
	IsFixed: False
	Value: 0.069
	Formula: 0.069

Parameter: PBPK_model_human_Ab|Organism|Gonads|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|Organism|Gonads|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0048
	Formula: 0.0048

Parameter: PBPK_model_human_Ab|Organism|Gonads|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0249
	Formula: 0.0249

Parameter: PBPK_model_human_Ab|Organism|Gonads|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0116
	Formula: 0.0116

Parameter: PBPK_model_human_Ab|Organism|Gonads|Vf (protein)-WS
	IsFixed: False
	Value: 0.13
	Formula: 0.13

Parameter: PBPK_model_human_Ab|Organism|Gonads|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.03
	Formula: 0.03

Parameter: PBPK_model_human_Ab|Organism|Gonads|Vf (water)-WS
	IsFixed: False
	Value: 0.78
	Formula: 0.78

Parameter: PBPK_model_human_Ab|Organism|Gonads|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.83
	Formula: 0.83

Parameter: PBPK_model_human_Ab|Organism|Gonads|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0054
	Formula: 0.0054

Parameter: PBPK_model_human_Ab|Organism|Gonads|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.45
	Formula: 2.45

Parameter: PBPK_model_human_Ab|Organism|Gonads|Volume
	IsFixed: False
	Value: 0.0402690567808118 [l]
	Percentile: 0.50017876895685

Parameter: PBPK_model_human_Ab|Organism|Gonads|Specific blood flow rate
	IsFixed: False
	Value: 0.0806 [l/min/kg organ]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Gonads|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.00117384300516067 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Gonads|Plasma|Volume(0.00117384300516067 [l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Plasma|Volume
	IsFixed: False
	Value: 0.00117384300516067 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|Gonads|Fraction vascular(0.055)
		V_org: PBPK_model_human_Ab|Organism|Gonads|Volume(0.0402690567808118 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Gonads|Plasma|Volume(0.00117384300516067 [l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Gonads|Plasma|Volume(0.00117384300516067 [l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.00104095511778399 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Gonads|BloodCells|Volume(0.00104095511778399 [l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|BloodCells|Volume
	IsFixed: False
	Value: 0.00104095511778399 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|Gonads|Fraction vascular(0.055)
		V: PBPK_model_human_Ab|Organism|Gonads|Volume(0.0402690567808118 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Gonads|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Gonads|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Gonads|BloodCells|Volume(0.00104095511778399 [l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|Gonads|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.00277856491787602 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Gonads|Interstitial|Volume(0.00277856491787602 [l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Interstitial|Volume
	IsFixed: False
	Value: 0.00277856491787602 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|Gonads|Fraction interstitial(0.069)
		V: PBPK_model_human_Ab|Organism|Gonads|Volume(0.0402690567808118 [l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Gonads|Interstitial|Volume(0.00277856491787602 [l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Gonads|Interstitial|Volume(0.00277856491787602 [l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.0402690567808118 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Gonads|Volume(0.0402690567808118 [l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Intracellular|Volume
	IsFixed: False
	Value: 0.0352756937399912 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|Gonads|Fraction intracellular(0.876)
		V: PBPK_model_human_Ab|Organism|Gonads|Volume(0.0402690567808118 [l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Intracellular|pH
	IsFixed: False
	Value: 7
	Formula: 7

Parameter: PBPK_model_human_Ab|Organism|Gonads|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Gonads|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Gonads|Intracellular|Volume(0.0352756937399912 [l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.22025216765946
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|Partition coefficient (intracellular/water)(1.22025216765946)

Parameter: PBPK_model_human_Ab|Organism|Gonads|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Endosome|Volume of protein container
	IsFixed: False
	Value: 1.26243493007845E-05 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Gonads|Endosome|Volume(1.26243493007845E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Endosome|Volume
	IsFixed: False
	Value: 1.26243493007845E-05 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|Gonads|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|Surface area (plasma/interstitial)(21.0405821679742 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Gonads|Endosome|Volume(1.26243493007845E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Gonads|Endosome|Volume(1.26243493007845E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Heart|Weight (tissue)
	IsFixed: False
	Value: 0.417601639973155 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|Heart|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|Heart|Volume(0.417601639973155 [l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Heart|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Heart|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|Heart|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Heart|Lymph flow rate
	IsFixed: False
	Value: 0.000202809065392218 [l/min]
	Formula: f_lymph*Q*(1-HCT)
		Q: PBPK_model_human_Ab|Organism|Heart|Blood flow rate(0.260311982277266 [l/min])
		f_lymph: PBPK_model_human_Ab|Organism|Heart|Lymph flow proportionality factor(0.00147)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Heart|Volume (endothelium)
	IsFixed: False
	Value: 0.00166623054349289 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|Surface area (plasma/interstitial)(555.410181164296 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Heart|Fluid recirculation flow rate
	IsFixed: False
	Value: 1.13227091465884E-05 [l/min]
	Formula: f_Jiso * (1-alpha_l) * Q_lymph * (V/V_mouse)^(exp_Jiso_scale - 1)
		alpha_l: PBPK_model_human_Ab|Organism|Heart|Flow fraction via large pores(0.05)
		f_Jiso: PBPK_model_human_Ab|Organism|Heart|Fluid recirculation flow proportionality factor(0.96)
		Q_lymph: PBPK_model_human_Ab|Organism|Heart|Lymph flow rate(0.000202809065392218 [l/min])
		V_mouse: PBPK_model_human_Ab|Organism|Heart|Organ volume mouse(9.5E-05 [l])
		V: PBPK_model_human_Ab|Organism|Heart|Volume(0.417601639973155 [l])
		exp_Jiso_scale: PBPK_model_human_Ab|Organism|Scaling exponent for fluid recirculation flow rate(0.667)

Parameter: PBPK_model_human_Ab|Organism|Heart|Fraction intracellular
	IsFixed: False
	Value: 0.76
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|Heart|Fraction interstitial(0.1)
		f_vas: PBPK_model_human_Ab|Organism|Heart|Fraction vascular(0.14)

Parameter: PBPK_model_human_Ab|Organism|Heart|Blood flow rate
	IsFixed: False
	Value: 0.260311982277266 [l/min]
	Formula: Qspec * Weight
		Qspec: PBPK_model_human_Ab|Organism|Heart|Specific blood flow rate(0.62335 [l/min/kg organ])
		Weight: PBPK_model_human_Ab|Organism|Heart|Weight (tissue)(0.417601639973155 [kg])

Parameter: PBPK_model_human_Ab|Organism|Heart|Lymph flow proportionality factor
	IsFixed: False
	Value: 0.00147
	Formula: 0.00147

Parameter: PBPK_model_human_Ab|Organism|Heart|Organ volume mouse
	IsFixed: False
	Value: 9.5E-05 [l]
	Formula: 9.5E-05

Parameter: PBPK_model_human_Ab|Organism|Heart|Fluid recirculation flow proportionality factor
	IsFixed: False
	Value: 0.96
	Formula: 0.96

Parameter: PBPK_model_human_Ab|Organism|Heart|Allometric scale factor
	IsFixed: False
	Value: 0.75
	Formula: 0.75

Parameter: PBPK_model_human_Ab|Organism|Heart|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Heart|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Heart|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|Heart|Hydraulic conductivity
	IsFixed: False
	Value: 1.43333333333333E-11 [l/min/(kg*dm/min²)]
	Formula: 1.43333333333333E-11

Parameter: PBPK_model_human_Ab|Organism|Heart|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|Heart|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|Heart|Vf (lipid)
	IsFixed: False
	Value: 0.1
	Formula: 0.1

Parameter: PBPK_model_human_Ab|Organism|Heart|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0115
	Formula: 0.0115

Parameter: PBPK_model_human_Ab|Organism|Heart|Fraction vascular
	IsFixed: False
	Value: 0.14
	Formula: 0.14

Parameter: PBPK_model_human_Ab|Organism|Heart|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0166
	Formula: 0.0166

Parameter: PBPK_model_human_Ab|Organism|Heart|Vf (protein)
	IsFixed: False
	Value: 0.168
	Formula: 0.168

Parameter: PBPK_model_human_Ab|Organism|Heart|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|Heart|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.16
	Formula: 0.16

Parameter: PBPK_model_human_Ab|Organism|Heart|Vf (water)
	IsFixed: False
	Value: 0.731
	Formula: 0.731

Parameter: PBPK_model_human_Ab|Organism|Heart|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.157
	Formula: 0.157

Parameter: PBPK_model_human_Ab|Organism|Heart|Vf (water)-PT
	IsFixed: False
	Value: 0.758
	Formula: 0.758

Parameter: PBPK_model_human_Ab|Organism|Heart|Fraction interstitial
	IsFixed: False
	Value: 0.1
	Formula: 0.1

Parameter: PBPK_model_human_Ab|Organism|Heart|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0528
	Formula: 0.0528

Parameter: PBPK_model_human_Ab|Organism|Heart|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0135
	Formula: 0.0135

Parameter: PBPK_model_human_Ab|Organism|Heart|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0106
	Formula: 0.0106

Parameter: PBPK_model_human_Ab|Organism|Heart|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0473
	Formula: 0.0473

Parameter: PBPK_model_human_Ab|Organism|Heart|Vf (protein)-WS
	IsFixed: False
	Value: 0.19
	Formula: 0.19

Parameter: PBPK_model_human_Ab|Organism|Heart|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.32
	Formula: 0.32

Parameter: PBPK_model_human_Ab|Organism|Heart|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.248
	Formula: 0.248

Parameter: PBPK_model_human_Ab|Organism|Heart|Vf (water)-WS
	IsFixed: False
	Value: 0.7
	Formula: 0.7

Parameter: PBPK_model_human_Ab|Organism|Heart|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.25
	Formula: 2.25

Parameter: PBPK_model_human_Ab|Organism|Heart|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0099
	Formula: 0.0099

Parameter: PBPK_model_human_Ab|Organism|Heart|Volume
	IsFixed: False
	Value: 0.417601639973155 [l]
	Percentile: 0.502004184577859

Parameter: PBPK_model_human_Ab|Organism|Heart|Specific blood flow rate
	IsFixed: False
	Value: 0.62335 [l/min/kg organ]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Heart|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.0309860416860081 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Heart|Plasma|Volume(0.0309860416860081 [l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Plasma|Volume
	IsFixed: False
	Value: 0.0309860416860081 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|Heart|Fraction vascular(0.14)
		V_org: PBPK_model_human_Ab|Organism|Heart|Volume(0.417601639973155 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Heart|Plasma|Volume(0.0309860416860081 [l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Heart|Plasma|Volume(0.0309860416860081 [l])

Parameter: PBPK_model_human_Ab|Organism|Heart|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.0274781879102336 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Heart|BloodCells|Volume(0.0274781879102336 [l])

Parameter: PBPK_model_human_Ab|Organism|Heart|BloodCells|Volume
	IsFixed: False
	Value: 0.0274781879102336 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|Heart|Fraction vascular(0.14)
		V: PBPK_model_human_Ab|Organism|Heart|Volume(0.417601639973155 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Heart|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Heart|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Heart|BloodCells|Volume(0.0274781879102336 [l])

Parameter: PBPK_model_human_Ab|Organism|Heart|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|Heart|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.0417601639973155 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Heart|Interstitial|Volume(0.0417601639973155 [l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Interstitial|Volume
	IsFixed: False
	Value: 0.0417601639973155 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|Heart|Fraction interstitial(0.1)
		V: PBPK_model_human_Ab|Organism|Heart|Volume(0.417601639973155 [l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Heart|Interstitial|Volume(0.0417601639973155 [l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Heart|Interstitial|Volume(0.0417601639973155 [l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.417601639973155 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Heart|Volume(0.417601639973155 [l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Intracellular|Volume
	IsFixed: False
	Value: 0.317377246379598 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|Heart|Fraction intracellular(0.76)
		V: PBPK_model_human_Ab|Organism|Heart|Volume(0.417601639973155 [l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Intracellular|pH
	IsFixed: False
	Value: 7.1
	Formula: 7.1

Parameter: PBPK_model_human_Ab|Organism|Heart|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Heart|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Heart|Intracellular|Volume(0.317377246379598 [l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.31873161968723
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|Partition coefficient (intracellular/water)(1.31873161968723)

Parameter: PBPK_model_human_Ab|Organism|Heart|Endosome|Volume of protein container
	IsFixed: False
	Value: 0.000333246108698578 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Heart|Endosome|Volume(0.000333246108698578 [l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Endosome|Volume
	IsFixed: False
	Value: 0.000333246108698578 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|Heart|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|Surface area (plasma/interstitial)(555.410181164296 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Heart|Endosome|Volume(0.000333246108698578 [l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Heart|Endosome|Volume(0.000333246108698578 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Kidney|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Weight (tissue)
	IsFixed: False
	Value: 0.438443334893072 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|Kidney|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|Kidney|Volume(0.438443334893072 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Kidney|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|Kidney|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Fluid recirculation flow rate
	IsFixed: False
	Value: 3.32038716868045E-05 [l/min]
	Formula: f_Jiso * (1-alpha_l) * Q_lymph * (V/V_mouse)^(exp_Jiso_scale - 1)
		alpha_l: PBPK_model_human_Ab|Organism|Kidney|Flow fraction via large pores(0.05)
		f_Jiso: PBPK_model_human_Ab|Organism|Kidney|Fluid recirculation flow proportionality factor(0.761)
		Q_lymph: PBPK_model_human_Ab|Organism|Kidney|Lymph flow rate(0.000498718147553631 [l/min])
		V_mouse: PBPK_model_human_Ab|Organism|Kidney|Organ volume mouse(0.00034 [l])
		V: PBPK_model_human_Ab|Organism|Kidney|Volume(0.438443334893072 [l])
		exp_Jiso_scale: PBPK_model_human_Ab|Organism|Scaling exponent for fluid recirculation flow rate(0.667)

Parameter: PBPK_model_human_Ab|Organism|Kidney|Volume (endothelium)
	IsFixed: False
	Value: 0.00287399606022409 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)(957.998686741362 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Lymph flow rate
	IsFixed: False
	Value: 0.000498718147553631 [l/min]
	Formula: f_lymph*Q*(1-HCT)
		Q: PBPK_model_human_Ab|Organism|Kidney|Blood flow rate(1.32718989688807 [l/min])
		f_lymph: PBPK_model_human_Ab|Organism|Kidney|Lymph flow proportionality factor(0.000709)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Kidney|Fraction intracellular
	IsFixed: False
	Value: 0.57
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|Kidney|Fraction interstitial(0.2)
		f_vas: PBPK_model_human_Ab|Organism|Kidney|Fraction vascular(0.23)

Parameter: PBPK_model_human_Ab|Organism|Kidney|GFR
	IsFixed: False
	Value: 0.116625927081557 [l/min]
	Formula: GFRspec * Weight_Kidney
		GFRspec: PBPK_model_human_Ab|Organism|Kidney|GFR (specific)(0.266 [l/min/kg organ])
		Weight_Kidney: PBPK_model_human_Ab|Organism|Kidney|Weight (tissue)(0.438443334893072 [kg])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Renal aging scaling factor
	IsFixed: False
	Value: 1
	Formula: Age <= Age_onset ? 1 : 1 - Decrease_Factor*(Age-Age_onset)^Hill/(TA50^Hill+(Age-Age_onset)^Hill)
		Age: PBPK_model_human_Ab|Organism|Age(30 [year(s)])
		Age_onset: PBPK_model_human_Ab|Organism|Kidney|Age of aging onset(30 [year(s)])
		TA50: PBPK_model_human_Ab|Organism|Kidney|Aging half-time(54 [year(s)])
		Hill: PBPK_model_human_Ab|Organism|Kidney|Hill coefficient for aging GFR(1.5)
		Decrease_Factor: PBPK_model_human_Ab|Organism|Kidney|Maximal decreasing rate factor(0.9)

Parameter: PBPK_model_human_Ab|Organism|Kidney|GFR (specific)
	IsFixed: False
	Value: 0.266 [l/min/kg organ]
	Formula: (PMA^Hill/(TM50^Hill+PMA^Hill)*(1-GFR_premat)+GFR_premat) * GFR_mat / V_kid_std * Renal_aging_scaling_factor
		PMA: PBPK_model_human_Ab|Organism|Estimated gestational age(1605.35714285714 [week(s)])
		GFR_premat: PBPK_model_human_Ab|Organism|Kidney|fGFRpremat(0.258)
		GFR_mat: PBPK_model_human_Ab|Organism|Kidney|GFRmat(0.11704 [l/min])
		Hill: PBPK_model_human_Ab|Organism|Kidney|Hill coefficient for GFR(15)
		Renal_aging_scaling_factor: PBPK_model_human_Ab|Organism|Kidney|Renal aging scaling factor(1)
		TM50: PBPK_model_human_Ab|Organism|Kidney|TM50 for GFR(44.4 [week(s)])
		V_kid_std: PBPK_model_human_Ab|Organism|Kidney|Volume (standard kidney)(0.44 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Blood flow rate
	IsFixed: False
	Value: 1.32718989688807 [l/min]
	Formula: Qspec * Weight
		Qspec: PBPK_model_human_Ab|Organism|Kidney|Specific blood flow rate(3.02705 [l/min/kg organ])
		Weight: PBPK_model_human_Ab|Organism|Kidney|Weight (tissue)(0.438443334893072 [kg])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Lymph flow proportionality factor
	IsFixed: False
	Value: 0.000709
	Formula: 0.000709

Parameter: PBPK_model_human_Ab|Organism|Kidney|Organ volume mouse
	IsFixed: False
	Value: 0.00034 [l]
	Formula: 0.00034

Parameter: PBPK_model_human_Ab|Organism|Kidney|Fluid recirculation flow proportionality factor
	IsFixed: False
	Value: 0.761
	Formula: 0.761

Parameter: PBPK_model_human_Ab|Organism|Kidney|Allometric scale factor
	IsFixed: False
	Value: 0.75
	Formula: 0.75

Parameter: PBPK_model_human_Ab|Organism|Kidney|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Kidney|Volume (standard kidney)
	IsFixed: False
	Value: 0.44 [l]
	Formula: 0.44

Parameter: PBPK_model_human_Ab|Organism|Kidney|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Kidney|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|Kidney|Hydraulic conductivity
	IsFixed: False
	Value: 1.25E-10 [l/min/(kg*dm/min²)]
	Formula: 1.25E-10

Parameter: PBPK_model_human_Ab|Organism|Kidney|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|Kidney|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|Kidney|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0207
	Formula: 0.0207

Parameter: PBPK_model_human_Ab|Organism|Kidney|Vf (lipid)
	IsFixed: False
	Value: 0.052
	Formula: 0.052

Parameter: PBPK_model_human_Ab|Organism|Kidney|Fraction vascular
	IsFixed: False
	Value: 0.23
	Formula: 0.23

Parameter: PBPK_model_human_Ab|Organism|Kidney|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0162
	Formula: 0.0162

Parameter: PBPK_model_human_Ab|Organism|Kidney|Vf (protein)
	IsFixed: False
	Value: 0.171
	Formula: 0.171

Parameter: PBPK_model_human_Ab|Organism|Kidney|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.13
	Formula: 0.13

Parameter: PBPK_model_human_Ab|Organism|Kidney|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|Kidney|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.137
	Formula: 0.137

Parameter: PBPK_model_human_Ab|Organism|Kidney|Vf (water)
	IsFixed: False
	Value: 0.774
	Formula: 0.774

Parameter: PBPK_model_human_Ab|Organism|Kidney|Vf (water)-PT
	IsFixed: False
	Value: 0.783
	Formula: 0.783

Parameter: PBPK_model_human_Ab|Organism|Kidney|Fraction interstitial
	IsFixed: False
	Value: 0.2
	Formula: 0.2

Parameter: PBPK_model_human_Ab|Organism|Kidney|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0121
	Formula: 0.0121

Parameter: PBPK_model_human_Ab|Organism|Kidney|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0156
	Formula: 0.0156

Parameter: PBPK_model_human_Ab|Organism|Kidney|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.024
	Formula: 0.024

Parameter: PBPK_model_human_Ab|Organism|Kidney|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0366
	Formula: 0.0366

Parameter: PBPK_model_human_Ab|Organism|Kidney|Vf (protein)-WS
	IsFixed: False
	Value: 0.21
	Formula: 0.21

Parameter: PBPK_model_human_Ab|Organism|Kidney|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.273
	Formula: 0.273

Parameter: PBPK_model_human_Ab|Organism|Kidney|Vf (water)-WS
	IsFixed: False
	Value: 0.73
	Formula: 0.73

Parameter: PBPK_model_human_Ab|Organism|Kidney|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.399
	Formula: 0.399

Parameter: PBPK_model_human_Ab|Organism|Kidney|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 5.03
	Formula: 5.03

Parameter: PBPK_model_human_Ab|Organism|Kidney|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0078
	Formula: 0.0078

Parameter: PBPK_model_human_Ab|Organism|Kidney|fGFRpremat
	IsFixed: False
	Value: 0.258
	Formula: 0.258

Parameter: PBPK_model_human_Ab|Organism|Kidney|Volume
	IsFixed: False
	Value: 0.438443334893072 [l]
	Percentile: 0.502676825589636

Parameter: PBPK_model_human_Ab|Organism|Kidney|Hill coefficient for GFR
	IsFixed: False
	Value: 15
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Kidney|TM50 for GFR
	IsFixed: False
	Value: 44.4 [week(s)]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Kidney|Maximal decreasing rate factor
	IsFixed: False
	Value: 0.9
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Kidney|Aging half-time
	IsFixed: False
	Value: 54 [year(s)]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Kidney|Age of aging onset
	IsFixed: False
	Value: 30 [year(s)]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Kidney|Hill coefficient for aging GFR
	IsFixed: False
	Value: 1.5
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Kidney|GFRmat
	IsFixed: False
	Value: 0.11704 [l/min]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Kidney|Specific blood flow rate
	IsFixed: False
	Value: 3.02705 [l/min/kg organ]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Kidney|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.0534462425234655 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Kidney|Plasma|Volume(0.0534462425234655 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Plasma|Volume
	IsFixed: False
	Value: 0.0534462425234655 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|Kidney|Fraction vascular(0.23)
		V_org: PBPK_model_human_Ab|Organism|Kidney|Volume(0.438443334893072 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Kidney|Plasma|Volume(0.0534462425234655 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Kidney|Plasma|Volume(0.0534462425234655 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.0473957245019411 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Kidney|BloodCells|Volume(0.0473957245019411 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|BloodCells|Volume
	IsFixed: False
	Value: 0.0473957245019411 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|Kidney|Fraction vascular(0.23)
		V: PBPK_model_human_Ab|Organism|Kidney|Volume(0.438443334893072 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Kidney|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Kidney|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Kidney|BloodCells|Volume(0.0473957245019411 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|Kidney|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.0876886669786144 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Kidney|Interstitial|Volume(0.0876886669786144 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Interstitial|Volume
	IsFixed: False
	Value: 0.0876886669786144 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|Kidney|Fraction interstitial(0.2)
		V: PBPK_model_human_Ab|Organism|Kidney|Volume(0.438443334893072 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Kidney|Interstitial|Volume(0.0876886669786144 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Kidney|Interstitial|Volume(0.0876886669786144 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.438443334893072 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Kidney|Volume(0.438443334893072 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Intracellular|Volume
	IsFixed: False
	Value: 0.249912700889051 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|Kidney|Fraction intracellular(0.57)
		V: PBPK_model_human_Ab|Organism|Kidney|Volume(0.438443334893072 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Intracellular|pH
	IsFixed: False
	Value: 7.22
	Formula: 7.22

Parameter: PBPK_model_human_Ab|Organism|Kidney|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Kidney|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Kidney|Intracellular|Volume(0.249912700889051 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.24720705329081
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|Partition coefficient (intracellular/water)(1.24720705329081)

Parameter: PBPK_model_human_Ab|Organism|Kidney|Endosome|Volume of protein container
	IsFixed: False
	Value: 0.000574799212044817 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Kidney|Endosome|Volume(0.000574799212044817 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Endosome|Volume
	IsFixed: False
	Value: 0.000574799212044817 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|Kidney|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)(957.998686741362 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Kidney|Endosome|Volume(0.000574799212044817 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Kidney|Endosome|Volume(0.000574799212044817 [l])

Parameter: PBPK_model_human_Ab|Organism|Kidney|Urine|Volume
	IsFixed: False
	Value: 1 [l]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Kidney|Urine|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Kidney|Urine|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Kidney|Urine|Volume(1 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|Paracellular absorption sink condition
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|Transcellular absorption sink condition
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|Effective surface area variability factor
	IsFixed: False
	Value: 1.00000000260982
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Secretion of liquid
	IsFixed: False
	Value: 0.00315929029220502 [l/min]
	Formula: SteadyStateFillLevel*V/StomachInflowTime
		SteadyStateFillLevel: PBPK_model_human_Ab|Organism|Lumen|Stomach|Fractional steady state fill level(0.030169)
		StomachInflowTime: PBPK_model_human_Ab|Organism|Lumen|Stomach|Inverse rate of inflow of liquid into stomach(15 [min])
		V: PBPK_model_human_Ab|Organism|Lumen|Stomach|Volume(1.5707963267949 [l])
		Time: PBPK_model_human_Ab|Time(0 [min])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Volume (gut wall)
	IsFixed: False
	Value: 0.142427244543147 [l]
	Formula: Area*d
		Area: PBPK_model_human_Ab|Organism|Lumen|Stomach|Geometric surface area(6.28318530717959 [dm²])
		d: PBPK_model_human_Ab|Organism|Lumen|Stomach|Thickness of gut wall(0.022668 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Intestinal transit rate (absolute)
	IsFixed: False
	Value: 0.0666666664926786 [1/min]
	Formula: 1/GET
		GET: PBPK_model_human_Ab|Organism|Lumen|Stomach|Gastric emptying time(15.0000000391473 [min])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Liquid transfer rate
	IsFixed: False
	Value: 0.00315929028395984 [l/min]
	Formula: w*Liquid*FillLevelFlagNext
		w: PBPK_model_human_Ab|Organism|Lumen|Stomach|Intestinal transit rate (absolute)(0.0666666664926786 [1/min])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Stomach|Liquid(0.0473893543830752 [l])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|Duodenum|FillLevelFlag(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Geometric surface area
	IsFixed: False
	Value: 6.28318530717959 [dm²]
	Formula: PI*(r1+r2)*L
		r2: PBPK_model_human_Ab|Organism|Lumen|Stomach|Distal radius(0.5 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|Stomach|Length(2 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|Stomach|Proximal radius(0.5 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|pH
	IsFixed: False
	Value: 2
	Formula: pH_fasted
		pH_fasted: PBPK_model_human_Ab|Organism|Lumen|Stomach|pH in fasted state(2)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Fraction of geometric volume filled with liquid
	IsFixed: False
	Value: 0.030169
	Formula: Liquid/V
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Stomach|Liquid(0.0473893543830752 [l])
		V: PBPK_model_human_Ab|Organism|Lumen|Stomach|Volume(1.5707963267949 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Volume
	IsFixed: False
	Value: 1.5707963267949 [l]
	Formula: PI*(r1*r1+r1*r2+r2*r2)/3*L
		r2: PBPK_model_human_Ab|Organism|Lumen|Stomach|Distal radius(0.5 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|Stomach|Length(2 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|Stomach|Proximal radius(0.5 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|GET of non-disintegrated moiety
	IsFixed: False
	Value: 60 [min]
	Formula: 60

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Volume of protein container
	IsFixed: False
	Value: 1.5707963267949 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lumen|Stomach|Volume(1.5707963267949 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Absorption of liquid
	IsFixed: False
	Value: 0 [1/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|FillLevelFlag
	IsFixed: False
	Value: 1
	Formula: (FillLevel<0.9?1:1/(1+exp((FillLevel-1)/0.01)))
		FillLevel: PBPK_model_human_Ab|Organism|Lumen|Stomach|Fraction of geometric volume filled with liquid(0.030169)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Liquid
	IsFixed: False
	Value: 0.0473893543830752 [l]
	Formula: V*SteadyStateFillLevel
		SteadyStateFillLevel: PBPK_model_human_Ab|Organism|Lumen|Stomach|Fractional steady state fill level(0.030169)
		V: PBPK_model_human_Ab|Organism|Lumen|Stomach|Volume(1.5707963267949 [l])
	RHS_Formula: OralApplicationsEnabled ? -LT_sto + Inflow*FillLevelFlag : 0
		FillLevelFlag: PBPK_model_human_Ab|Organism|Lumen|Stomach|FillLevelFlag(1)
		LT_sto: PBPK_model_human_Ab|Organism|Lumen|Stomach|Liquid transfer rate(0.00315929028395984 [l/min])
		Inflow: PBPK_model_human_Ab|Organism|Lumen|Stomach|Secretion of liquid(0.00315929029220502 [l/min])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Thickness of gut wall
	IsFixed: False
	Value: 0.022668 [dm]
	Formula: 0.022668

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|pH in fed state
	IsFixed: False
	Value: 5.5
	Formula: 5.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Fractional steady state fill level
	IsFixed: False
	Value: 0.030169
	Formula: 0.030169

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Inverse rate of inflow of liquid into stomach
	IsFixed: False
	Value: 15 [min]
	Formula: 15

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|pH in fasted state
	IsFixed: False
	Value: 2
	Formula: 2

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Proximal radius
	IsFixed: False
	Value: 0.5 [dm]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Length
	IsFixed: False
	Value: 2 [dm]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Gastric emptying time
	IsFixed: False
	Value: 15.0000000391473 [min]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|GET_alpha (Weibull function) variability factor
	IsFixed: False
	Value: 1.00000002079922
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|GET_beta (Weibull function) variability factor
	IsFixed: False
	Value: 0.999999963215789
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|Distal radius
	IsFixed: False
	Value: 0.5 [dm]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lumen|Stomach|Volume(1.5707963267949 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|Stomach|pH(2)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|Stomach|pH(2)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|Stomach|pH(2)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|Solubility_pKa_pH_Factor
	IsFixed: False
	Value: 1
	Formula: K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)
		K1: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_K8(0)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		base: PBPK_model_human_Ab|CDA1|Solubility gain per charge(1000)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|Solubility
	IsFixed: False
	Value: 0.000999 [kg/l]
	Formula: Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor
		Solubility_pKa_pH_Factor: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|Solubility_pKa_pH_Factor(1)
		Solubility: PBPK_model_human_Ab|CDA1|Solubility at reference pH(0.000999 [kg/l])
		Solubility_pKa_REFpH_Factor: PBPK_model_human_Ab|CDA1|Solubility_pKa_pH_Factor(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Volume (gut wall)
	IsFixed: False
	Value: 0.06302870159981 [l]
	Formula: V_Intestine * 0.087
		V_Intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Volume of protein container
	IsFixed: False
	Value: 0.200858715939871 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Volume(0.200858715939871 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Volume
	IsFixed: False
	Value: 0.200858715939871 [l]
	Formula: PI*(r1*r1+r1*r2+r2*r2)/3*L
		r2: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Distal radius(0.1608833079 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Length(2.252366346 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Proximal radius(0.1759661202 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Length
	IsFixed: False
	Value: 2.252366346 [dm]
	Formula: L_p0 + Height*L_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		L_p0: PBPK_model_human_Ab|Organism|Lumen|Duodenum|L_p0(-0.0289872252 [dm])
		L_p1: PBPK_model_human_Ab|Organism|Lumen|Duodenum|L_p1(0.129622362)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Absorption of liquid
	IsFixed: False
	Value: -0.881716648412967 [1/min]
	Formula: (k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)
		alpha: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Fractional steady state fill level(0.06)
		k: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Intestinal transit rate (absolute)(1.62619861602195 [1/min])
		inflow: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Secretion of liquid(0.00581285123929987 [l/min])
		V: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Volume(0.200858715939871 [l])
		alpha_p: PBPK_model_human_Ab|Organism|Lumen|Stomach|Fractional steady state fill level(0.030169)
		k_p: PBPK_model_human_Ab|Organism|Lumen|Stomach|Intestinal transit rate (absolute)(0.0666666664926786 [1/min])
		V_p: PBPK_model_human_Ab|Organism|Lumen|Stomach|Volume(1.5707963267949 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Distal radius
	IsFixed: False
	Value: 0.1608833079 [dm]
	Formula: r2_p0 + Height*r2_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r2_p0: PBPK_model_human_Ab|Organism|Lumen|Duodenum|r2_p0(-0.0020705161 [dm])
		r2_p1: PBPK_model_human_Ab|Organism|Lumen|Duodenum|r2_p1(0.00925874)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Effective surface area
	IsFixed: False
	Value: 697.637922302124 [dm²]
	Formula: Ageom*AeffFactor*AeffVariabilityFactor
		AeffFactor: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Effective surface area enhancement factor(292.6883)
		Ageom: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Geometric surface area(2.38355247026073 [dm²])
		AeffVariabilityFactor: PBPK_model_human_Ab|Organism|Lumen|Effective surface area variability factor(1.00000000260982)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|FillLevelFlag
	IsFixed: False
	Value: 1
	Formula: (FillLevel<0.9?1:1/(1+exp((FillLevel-1)/0.01)))
		FillLevel: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Fraction of geometric volume filled with liquid(0.06)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Fraction of geometric volume filled with liquid
	IsFixed: False
	Value: 0.06
	Formula: Liquid/V
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Liquid(0.0120515229563923 [l])
		V: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Volume(0.200858715939871 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Geometric surface area
	IsFixed: False
	Value: 2.38355247026073 [dm²]
	Formula: PI*(r1+r2)*L
		r2: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Distal radius(0.1608833079 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Length(2.252366346 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Proximal radius(0.1759661202 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Liquid
	IsFixed: False
	Value: 0.0120515229563923 [l]
	Formula: V*SteadyStateFillLevel
		SteadyStateFillLevel: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Fractional steady state fill level(0.06)
		V: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Volume(0.200858715939871 [l])
	RHS_Formula: OralApplicationsEnabled ? LT_sto - LT_duo + Inflow*FillLevelFlag - Outflow*Liquid : 0
		Outflow: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Absorption of liquid(-0.881716648412967 [1/min])
		FillLevelFlag: PBPK_model_human_Ab|Organism|Lumen|Duodenum|FillLevelFlag(1)
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Liquid(0.0120515229563923 [l])
		LT_duo: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Liquid transfer rate(0.0195981699526418 [l/min])
		Inflow: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Secretion of liquid(0.00581285123929987 [l/min])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		LT_sto: PBPK_model_human_Ab|Organism|Lumen|Stomach|Liquid transfer rate(0.00315929028395984 [l/min])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Liquid transfer rate
	IsFixed: False
	Value: 0.0195981699526418 [l/min]
	Formula: w*Liquid*FillLevelFlagNext
		w: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Intestinal transit rate (absolute)(1.62619861602195 [1/min])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Liquid(0.0120515229563923 [l])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|FillLevelFlag(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Proximal radius
	IsFixed: False
	Value: 0.1759661202 [dm]
	Formula: r1_p0 + Height*r1_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r1_p0: PBPK_model_human_Ab|Organism|Lumen|Duodenum|r1_p0(-0.002264627 [dm])
		r1_p1: PBPK_model_human_Ab|Organism|Lumen|Duodenum|r1_p1(0.010126747)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Secretion of liquid
	IsFixed: False
	Value: 0.00581285123929987 [l/min]
	Formula: 0.02894*V
		V: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Volume(0.200858715939871 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Thickness of gut wall
	IsFixed: False
	Value: 0.0252518777358106 [dm]
	Formula: Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		Thickness_p1: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Thickness_p1(-0.0186500479 [dm])
		Thickness_p2: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Thickness_p2(0.0441002752 [dm])
		Thickness_p3: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Thickness_p3(-0.30705627 [1/dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Intestinal transit rate (absolute)
	IsFixed: False
	Value: 1.62619861602195 [1/min]
	Formula: LuminalVelocity/SITT_fact
		LuminalVelocity: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Intestinal transit rate(116 [1/min])
		SITT_fact: PBPK_model_human_Ab|Organism|SmallIntestine|Small intestinal transit time factor(71.3320001979601)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|L_p1
	IsFixed: False
	Value: 0.129622362
	Formula: 0.129622362

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Thickness_p3
	IsFixed: False
	Value: -0.30705627 [1/dm]
	Formula: -0.30705627

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|r1_p0
	IsFixed: False
	Value: -0.002264627 [dm]
	Formula: -0.002264627

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|r1_p1
	IsFixed: False
	Value: 0.010126747
	Formula: 0.010126747

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|r2_p0
	IsFixed: False
	Value: -0.0020705161 [dm]
	Formula: -0.0020705161

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|r2_p1
	IsFixed: False
	Value: 0.00925874
	Formula: 0.00925874

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Thickness_p2
	IsFixed: False
	Value: 0.0441002752 [dm]
	Formula: 0.0441002752

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Thickness_p1
	IsFixed: False
	Value: -0.0186500479 [dm]
	Formula: -0.0186500479

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|L_p0
	IsFixed: False
	Value: -0.0289872252 [dm]
	Formula: -0.0289872252

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Microvilli factor
	IsFixed: False
	Value: 25
	Formula: 25

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Intestinal transit rate
	IsFixed: False
	Value: 116 [1/min]
	Formula: 116

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Fractional steady state fill level
	IsFixed: False
	Value: 0.06
	Formula: 0.06

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|pH
	IsFixed: False
	Value: 6
	Formula: 6

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Effective surface area enhancement factor
	IsFixed: False
	Value: 292.6883
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Volume(0.200858715939871 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|Solubility
	IsFixed: False
	Value: 0.000999 [kg/l]
	Formula: Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor
		Solubility_pKa_pH_Factor: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|Solubility_pKa_pH_Factor(1)
		Solubility: PBPK_model_human_Ab|CDA1|Solubility at reference pH(0.000999 [kg/l])
		Solubility_pKa_REFpH_Factor: PBPK_model_human_Ab|CDA1|Solubility_pKa_pH_Factor(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|Duodenum|pH(6)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|Duodenum|pH(6)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|Solubility_pKa_pH_Factor
	IsFixed: False
	Value: 1
	Formula: K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)
		K1: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_K8(0)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		base: PBPK_model_human_Ab|CDA1|Solubility gain per charge(1000)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|Duodenum|pH(6)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|Oral mass absorbed segment
	IsFixed: False
	Value: 0 [µmol]
	Formula: 0
	RHS_Formula: PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)
		ActiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_pls|CDA1|Sum of active process rates(0 [µmol/min])
		ActiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|Sum of active process rates(0 [µmol/min])
		PassiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_pls|CDA1|Sum of passive process rates(0 [µmol/min])
		PassiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|Sum of passive process rates(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Volume
	IsFixed: False
	Value: 0.397618584412149 [l]
	Formula: PI*(r1*r1+r1*r2+r2*r2)/3*L
		r2: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Distal radius(0.1508281056 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Length(5.208597173 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Proximal radius(0.1608833079 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Volume (gut wall)
	IsFixed: False
	Value: 0.180392490785663 [l]
	Formula: V_Intestine * 0.249
		V_Intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Volume of protein container
	IsFixed: False
	Value: 0.397618584412149 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Volume(0.397618584412149 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Thickness of gut wall
	IsFixed: False
	Value: 0.0337735795268098 [dm]
	Formula: Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		Thickness_p1: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Thickness_p1(-0.024936327 [dm])
		Thickness_p2: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Thickness_p2(0.0589752766 [dm])
		Thickness_p3: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Thickness_p3(-0.30703115 [1/dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Geometric surface area
	IsFixed: False
	Value: 5.10062444686524 [dm²]
	Formula: PI*(r1+r2)*L
		r2: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Distal radius(0.1508281056 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Length(5.208597173 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Proximal radius(0.1608833079 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Absorption of liquid
	IsFixed: False
	Value: 0.738519260697634 [1/min]
	Formula: (k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)
		alpha: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Fractional steady state fill level(0.064841)
		k: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Intestinal transit rate (absolute)(0.0703218749800801 [1/min])
		inflow: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Secretion of liquid(0.00125536139470604 [l/min])
		V: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Volume(0.397618584412149 [l])
		alpha_p: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Fractional steady state fill level(0.06)
		k_p: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Intestinal transit rate (absolute)(1.62619861602195 [1/min])
		V_p: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Volume(0.200858715939871 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Distal radius
	IsFixed: False
	Value: 0.1508281056 [dm]
	Formula: r2_p0 + Height*r2_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r2_p0: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|r2_p0(-0.0019411088 [dm])
		r2_p1: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|r2_p1(0.008680069)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Effective surface area
	IsFixed: False
	Value: 2285.01702047842 [dm²]
	Formula: Ageom*AeffFactor*AeffVariabilityFactor
		AeffFactor: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Effective surface area enhancement factor(447.9877)
		Ageom: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Geometric surface area(5.10062444686524 [dm²])
		AeffVariabilityFactor: PBPK_model_human_Ab|Organism|Lumen|Effective surface area variability factor(1.00000000260982)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Fraction of geometric volume filled with liquid
	IsFixed: False
	Value: 0.064841
	Formula: Liquid/V
		Liquid: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Liquid(0.0257819866318681 [l])
		V: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Volume(0.397618584412149 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Intestinal transit rate (absolute)
	IsFixed: False
	Value: 0.0703218749800801 [1/min]
	Formula: LuminalVelocity/SITT_fact
		LuminalVelocity: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Intestinal transit rate(5.0162 [1/min])
		SITT_fact: PBPK_model_human_Ab|Organism|SmallIntestine|Small intestinal transit time factor(71.3320001979601)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Length
	IsFixed: False
	Value: 5.208597173 [dm]
	Formula: L_p0 + Height*L_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		L_p0: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|L_p0(-0.0670329582 [dm])
		L_p1: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|L_p1(0.299751712)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Liquid
	IsFixed: False
	Value: 0.0257819866318681 [l]
	Formula: V*SteadyStateFillLevel
		SteadyStateFillLevel: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Fractional steady state fill level(0.064841)
		V: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Volume(0.397618584412149 [l])
	RHS_Formula: OralApplicationsEnabled ? LT_duo - LT_uje + Inflow*FillLevelFlag - Outflow*Liquid : 0
		Outflow: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Absorption of liquid(0.738519260697634 [1/min])
		FillLevelFlag: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|FillLevelFlag(1)
		Liquid: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Liquid(0.0257819866318681 [l])
		LT_uje: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Liquid transfer rate(0.00181303764066433 [l/min])
		Inflow: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Secretion of liquid(0.00125536139470604 [l/min])
		LT_duo: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Liquid transfer rate(0.0195981699526418 [l/min])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Liquid transfer rate
	IsFixed: False
	Value: 0.00181303764066433 [l/min]
	Formula: w*Liquid*FillLevelFlagNext
		w: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Intestinal transit rate (absolute)(0.0703218749800801 [1/min])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Liquid(0.0257819866318681 [l])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|FillLevelFlag(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Proximal radius
	IsFixed: False
	Value: 0.1608833079 [dm]
	Formula: r1_p0 + Height*r1_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r1_p0: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|r1_p0(-0.0020705161 [dm])
		r1_p1: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|r1_p1(0.00925874)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Secretion of liquid
	IsFixed: False
	Value: 0.00125536139470604 [l/min]
	Formula: 0.0031572*V
		V: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Volume(0.397618584412149 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|FillLevelFlag
	IsFixed: False
	Value: 1
	Formula: (FillLevel<0.9?1:1/(1+exp((FillLevel-1)/0.01)))
		FillLevel: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Fraction of geometric volume filled with liquid(0.064841)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Microvilli factor
	IsFixed: False
	Value: 25
	Formula: 25

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Thickness_p3
	IsFixed: False
	Value: -0.30703115 [1/dm]
	Formula: -0.30703115

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Thickness_p2
	IsFixed: False
	Value: 0.0589752766 [dm]
	Formula: 0.0589752766

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Thickness_p1
	IsFixed: False
	Value: -0.024936327 [dm]
	Formula: -0.024936327

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|r2_p1
	IsFixed: False
	Value: 0.008680069
	Formula: 0.008680069

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|r2_p0
	IsFixed: False
	Value: -0.0019411088 [dm]
	Formula: -0.0019411088

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|r1_p1
	IsFixed: False
	Value: 0.00925874
	Formula: 0.00925874

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|r1_p0
	IsFixed: False
	Value: -0.0020705161 [dm]
	Formula: -0.0020705161

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Fractional steady state fill level
	IsFixed: False
	Value: 0.064841
	Formula: 0.064841

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Intestinal transit rate
	IsFixed: False
	Value: 5.0162 [1/min]
	Formula: 5.0162

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|L_p0
	IsFixed: False
	Value: -0.0670329582 [dm]
	Formula: -0.0670329582

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|L_p1
	IsFixed: False
	Value: 0.299751712
	Formula: 0.299751712

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|pH
	IsFixed: False
	Value: 6.25
	Formula: 6.25

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Effective surface area enhancement factor
	IsFixed: False
	Value: 447.9877
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Volume(0.397618584412149 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|pH(6.25)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|Oral mass absorbed segment
	IsFixed: False
	Value: 0 [µmol]
	Formula: 0
	RHS_Formula: PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)
		ActiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_pls|CDA1|Sum of active process rates(0 [µmol/min])
		ActiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|Sum of active process rates(0 [µmol/min])
		PassiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_pls|CDA1|Sum of passive process rates(0 [µmol/min])
		PassiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|Sum of passive process rates(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|pH(6.25)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|pH(6.25)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|Solubility
	IsFixed: False
	Value: 0.000999 [kg/l]
	Formula: Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor
		Solubility_pKa_pH_Factor: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|Solubility_pKa_pH_Factor(1)
		Solubility: PBPK_model_human_Ab|CDA1|Solubility at reference pH(0.000999 [kg/l])
		Solubility_pKa_REFpH_Factor: PBPK_model_human_Ab|CDA1|Solubility_pKa_pH_Factor(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|Solubility_pKa_pH_Factor
	IsFixed: False
	Value: 1
	Formula: K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)
		K1: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|pKa_pH_WS_lum_K8(0)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		base: PBPK_model_human_Ab|CDA1|Solubility gain per charge(1000)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Volume (gut wall)
	IsFixed: False
	Value: 0.133302081544426 [l]
	Formula: V_Intestine * 0.184
		V_Intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Length
	IsFixed: False
	Value: 5.208597173 [dm]
	Formula: L_p0 + Height*L_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		L_p0: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|L_p0(-0.0670329582 [dm])
		L_p1: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|L_p1(0.299751712)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Absorption of liquid
	IsFixed: False
	Value: 0.0487432162951318 [1/min]
	Formula: (k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)
		alpha: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Fractional steady state fill level(0.064841)
		k: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Intestinal transit rate (absolute)(0.0703218749800801 [1/min])
		inflow: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Secretion of liquid(0.000873512494869936 [l/min])
		V: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Volume(0.347985218257484 [l])
		alpha_p: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Fractional steady state fill level(0.064841)
		k_p: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Intestinal transit rate (absolute)(0.0703218749800801 [1/min])
		V_p: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Volume(0.397618584412149 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Distal radius
	IsFixed: False
	Value: 0.1407729032 [dm]
	Formula: r2_p0 + Height*r2_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r2_p0: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|r2_p0(-0.0018117016 [dm])
		r2_p1: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|r2_p1(0.008101398)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Effective surface area
	IsFixed: False
	Value: 1779.48258579791 [dm²]
	Formula: Ageom*AeffFactor*AeffVariabilityFactor
		AeffFactor: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Effective surface area enhancement factor(372.9358)
		Ageom: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Geometric surface area(4.77155205038986 [dm²])
		AeffVariabilityFactor: PBPK_model_human_Ab|Organism|Lumen|Effective surface area variability factor(1.00000000260982)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|FillLevelFlag
	IsFixed: False
	Value: 1
	Formula: (FillLevel<0.9?1:1/(1+exp((FillLevel-1)/0.01)))
		FillLevel: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Fraction of geometric volume filled with liquid(0.064841)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Fraction of geometric volume filled with liquid
	IsFixed: False
	Value: 0.064841
	Formula: Liquid/V
		Liquid: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Liquid(0.0225637095370335 [l])
		V: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Volume(0.347985218257484 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Intestinal transit rate (absolute)
	IsFixed: False
	Value: 0.0703218749800801 [1/min]
	Formula: LuminalVelocity/SITT_fact
		LuminalVelocity: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Intestinal transit rate(5.0162 [1/min])
		SITT_fact: PBPK_model_human_Ab|Organism|SmallIntestine|Small intestinal transit time factor(71.3320001979601)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Volume of protein container
	IsFixed: False
	Value: 0.347985218257484 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Volume(0.347985218257484 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Liquid
	IsFixed: False
	Value: 0.0225637095370335 [l]
	Formula: V*SteadyStateFillLevel
		SteadyStateFillLevel: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Fractional steady state fill level(0.064841)
		V: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Volume(0.347985218257484 [l])
	RHS_Formula: OralApplicationsEnabled ? LT_uje - LT_lje + Inflow*FillLevelFlag - Outflow*Liquid : 0
		Outflow: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Absorption of liquid(0.0487432162951318 [1/min])
		FillLevelFlag: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|FillLevelFlag(1)
		Liquid: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Liquid(0.0225637095370335 [l])
		LT_lje: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Liquid transfer rate(0.00158672236115011 [l/min])
		Inflow: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Secretion of liquid(0.000873512494869936 [l/min])
		LT_uje: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Liquid transfer rate(0.00181303764066433 [l/min])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Liquid transfer rate
	IsFixed: False
	Value: 0.00158672236115011 [l/min]
	Formula: w*Liquid*FillLevelFlagNext
		w: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Intestinal transit rate (absolute)(0.0703218749800801 [1/min])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Liquid(0.0225637095370335 [l])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|FillLevelFlag(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Proximal radius
	IsFixed: False
	Value: 0.1508281056 [dm]
	Formula: r1_p0 + Height*r1_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r1_p0: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|r1_p0(-0.0019411088 [dm])
		r1_p1: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|r1_p1(0.008680069)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Secretion of liquid
	IsFixed: False
	Value: 0.000873512494869936 [l/min]
	Formula: 0.0025102*V
		V: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Volume(0.347985218257484 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Thickness of gut wall
	IsFixed: False
	Value: 0.0266783683244172 [dm]
	Formula: Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		Thickness_p1: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Thickness_p1(-0.0196976609 [dm])
		Thickness_p2: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Thickness_p2(0.0465856499 [dm])
		Thickness_p3: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Thickness_p3(-0.30703115 [1/dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Volume
	IsFixed: False
	Value: 0.347985218257484 [l]
	Formula: PI*(r1*r1+r1*r2+r2*r2)/3*L
		r2: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Distal radius(0.1407729032 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Length(5.208597173 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Proximal radius(0.1508281056 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Geometric surface area
	IsFixed: False
	Value: 4.77155205038986 [dm²]
	Formula: PI*(r1+r2)*L
		r2: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Distal radius(0.1407729032 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Length(5.208597173 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Proximal radius(0.1508281056 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|r1_p0
	IsFixed: False
	Value: -0.0019411088 [dm]
	Formula: -0.0019411088

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Microvilli factor
	IsFixed: False
	Value: 25
	Formula: 25

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|L_p1
	IsFixed: False
	Value: 0.299751712
	Formula: 0.299751712

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|L_p0
	IsFixed: False
	Value: -0.0670329582 [dm]
	Formula: -0.0670329582

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Intestinal transit rate
	IsFixed: False
	Value: 5.0162 [1/min]
	Formula: 5.0162

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Fractional steady state fill level
	IsFixed: False
	Value: 0.064841
	Formula: 0.064841

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|r2_p0
	IsFixed: False
	Value: -0.0018117016 [dm]
	Formula: -0.0018117016

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|r2_p1
	IsFixed: False
	Value: 0.008101398
	Formula: 0.008101398

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|r1_p1
	IsFixed: False
	Value: 0.008680069
	Formula: 0.008680069

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Thickness_p1
	IsFixed: False
	Value: -0.0196976609 [dm]
	Formula: -0.0196976609

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Thickness_p2
	IsFixed: False
	Value: 0.0465856499 [dm]
	Formula: 0.0465856499

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Thickness_p3
	IsFixed: False
	Value: -0.30703115 [1/dm]
	Formula: -0.30703115

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|pH
	IsFixed: False
	Value: 6.9167
	Formula: 6.9167

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Effective surface area enhancement factor
	IsFixed: False
	Value: 372.9358
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Volume(0.347985218257484 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|Solubility
	IsFixed: False
	Value: 0.000999 [kg/l]
	Formula: Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor
		Solubility_pKa_pH_Factor: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|Solubility_pKa_pH_Factor(1)
		Solubility: PBPK_model_human_Ab|CDA1|Solubility at reference pH(0.000999 [kg/l])
		Solubility_pKa_REFpH_Factor: PBPK_model_human_Ab|CDA1|Solubility_pKa_pH_Factor(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|pH(6.9167)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|pH(6.9167)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|Solubility_pKa_pH_Factor
	IsFixed: False
	Value: 1
	Formula: K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)
		K1: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_K8(0)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		base: PBPK_model_human_Ab|CDA1|Solubility gain per charge(1000)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|pH(6.9167)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|Oral mass absorbed segment
	IsFixed: False
	Value: 0 [µmol]
	Formula: 0
	RHS_Formula: PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)
		ActiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_pls|CDA1|Sum of active process rates(0 [µmol/min])
		ActiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|Sum of active process rates(0 [µmol/min])
		PassiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_pls|CDA1|Sum of passive process rates(0 [µmol/min])
		PassiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|Sum of passive process rates(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Distal radius
	IsFixed: False
	Value: 0.1206624809 [dm]
	Formula: r2_p0 + Height*r2_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r2_p0: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|r2_p0(-0.0015528871 [dm])
		r2_p1: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|r2_p1(0.006944055)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Effective surface area
	IsFixed: False
	Value: 1658.15372565961 [dm²]
	Formula: Ageom*AeffFactor*AeffVariabilityFactor
		AeffFactor: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Effective surface area enhancement factor(260.7527)
		Ageom: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Geometric surface area(6.35910470469577 [dm²])
		AeffVariabilityFactor: PBPK_model_human_Ab|Organism|Lumen|Effective surface area variability factor(1.00000000260982)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|FillLevelFlag
	IsFixed: False
	Value: 1
	Formula: (FillLevel<0.9?1:1/(1+exp((FillLevel-1)/0.01)))
		FillLevel: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Fraction of geometric volume filled with liquid(0.064841)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Fraction of geometric volume filled with liquid
	IsFixed: False
	Value: 0.064841
	Formula: Liquid/V
		Liquid: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Liquid(0.0270026140608501 [l])
		V: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Volume(0.416443516615261 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Geometric surface area
	IsFixed: False
	Value: 6.35910470469577 [dm²]
	Formula: PI*(r1+r2)*L
		r2: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Distal radius(0.1206624809 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Length(7.7425093078 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Proximal radius(0.1407729032 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Intestinal transit rate (absolute)
	IsFixed: False
	Value: 0.0473069588772936 [1/min]
	Formula: LuminalVelocity/SITT_fact
		LuminalVelocity: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Intestinal transit rate(3.3745 [1/min])
		SITT_fact: PBPK_model_human_Ab|Organism|SmallIntestine|Small intestinal transit time factor(71.3320001979601)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Length
	IsFixed: False
	Value: 7.7425093078 [dm]
	Formula: L_p0 + Height*L_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		L_p0: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|L_p0(-0.0996435866 [dm])
		L_p1: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|L_p1(0.445576869)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Liquid
	IsFixed: False
	Value: 0.0270026140608501 [l]
	Formula: V*SteadyStateFillLevel
		SteadyStateFillLevel: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Fractional steady state fill level(0.064841)
		V: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Volume(0.416443516615261 [l])
	RHS_Formula: OralApplicationsEnabled ? LT_lje - LT_uil + Inflow*FillLevelFlag - Outflow*Liquid : 0
		Outflow: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Absorption of liquid(0.0570818420996891 [1/min])
		FillLevelFlag: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|FillLevelFlag(1)
		Liquid: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Liquid(0.0270026140608501 [l])
		LT_uil: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Liquid transfer rate(0.00127741155295607 [l/min])
		Inflow: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Secretion of liquid(0.00123204814390625 [l/min])
		LT_lje: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Liquid transfer rate(0.00158672236115011 [l/min])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Liquid transfer rate
	IsFixed: False
	Value: 0.00127741155295607 [l/min]
	Formula: w*Liquid*FillLevelFlagNext
		w: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Intestinal transit rate (absolute)(0.0473069588772936 [1/min])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Liquid(0.0270026140608501 [l])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|FillLevelFlag(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Proximal radius
	IsFixed: False
	Value: 0.1407729032 [dm]
	Formula: r1_p0 + Height*r1_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r1_p0: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|r1_p0(-0.0018117016 [dm])
		r1_p1: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|r1_p1(0.008101398)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Thickness of gut wall
	IsFixed: False
	Value: 0.0352492706383363 [dm]
	Formula: Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		Thickness_p1: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Thickness_p1(-0.0260258863 [dm])
		Thickness_p2: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Thickness_p2(0.061552122 [dm])
		Thickness_p3: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Thickness_p3(-0.30703115 [1/dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Volume
	IsFixed: False
	Value: 0.416443516615261 [l]
	Formula: PI*(r1*r1+r1*r2+r2*r2)/3*L
		r2: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Distal radius(0.1206624809 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Length(7.7425093078 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Proximal radius(0.1407729032 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Volume (gut wall)
	IsFixed: False
	Value: 0.234727578371706 [l]
	Formula: V_Intestine * 0.324
		V_Intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Volume of protein container
	IsFixed: False
	Value: 0.416443516615261 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Volume(0.416443516615261 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Secretion of liquid
	IsFixed: False
	Value: 0.00123204814390625 [l/min]
	Formula: 0.0029585*V
		V: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Volume(0.416443516615261 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Absorption of liquid
	IsFixed: False
	Value: 0.0570818420996891 [1/min]
	Formula: (k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)
		alpha: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Fractional steady state fill level(0.064841)
		k: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Intestinal transit rate (absolute)(0.0473069588772936 [1/min])
		inflow: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Secretion of liquid(0.00123204814390625 [l/min])
		V: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Volume(0.416443516615261 [l])
		alpha_p: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Fractional steady state fill level(0.064841)
		k_p: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Intestinal transit rate (absolute)(0.0703218749800801 [1/min])
		V_p: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Volume(0.347985218257484 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Thickness_p1
	IsFixed: False
	Value: -0.0260258863 [dm]
	Formula: -0.0260258863

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|L_p1
	IsFixed: False
	Value: 0.445576869
	Formula: 0.445576869

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Fractional steady state fill level
	IsFixed: False
	Value: 0.064841
	Formula: 0.064841

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Thickness_p3
	IsFixed: False
	Value: -0.30703115 [1/dm]
	Formula: -0.30703115

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|L_p0
	IsFixed: False
	Value: -0.0996435866 [dm]
	Formula: -0.0996435866

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Thickness_p2
	IsFixed: False
	Value: 0.061552122 [dm]
	Formula: 0.061552122

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Microvilli factor
	IsFixed: False
	Value: 25
	Formula: 25

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|r1_p0
	IsFixed: False
	Value: -0.0018117016 [dm]
	Formula: -0.0018117016

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|r1_p1
	IsFixed: False
	Value: 0.008101398
	Formula: 0.008101398

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|r2_p0
	IsFixed: False
	Value: -0.0015528871 [dm]
	Formula: -0.0015528871

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|r2_p1
	IsFixed: False
	Value: 0.006944055
	Formula: 0.006944055

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Intestinal transit rate
	IsFixed: False
	Value: 3.3745 [1/min]
	Formula: 3.3745

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|pH
	IsFixed: False
	Value: 7.2083
	Formula: 7.2083

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Effective surface area enhancement factor
	IsFixed: False
	Value: 260.7527
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Volume(0.416443516615261 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|pH(7.2083)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|pH(7.2083)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|pH(7.2083)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|Solubility
	IsFixed: False
	Value: 0.000999 [kg/l]
	Formula: Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor
		Solubility_pKa_pH_Factor: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|Solubility_pKa_pH_Factor(1)
		Solubility: PBPK_model_human_Ab|CDA1|Solubility at reference pH(0.000999 [kg/l])
		Solubility_pKa_REFpH_Factor: PBPK_model_human_Ab|CDA1|Solubility_pKa_pH_Factor(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|Solubility_pKa_pH_Factor
	IsFixed: False
	Value: 1
	Formula: K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)
		K1: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_K8(0)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		base: PBPK_model_human_Ab|CDA1|Solubility gain per charge(1000)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|Oral mass absorbed segment
	IsFixed: False
	Value: 0 [µmol]
	Formula: 0
	RHS_Formula: PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)
		ActiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_pls|CDA1|Sum of active process rates(0 [µmol/min])
		ActiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|Sum of active process rates(0 [µmol/min])
		PassiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_pls|CDA1|Sum of passive process rates(0 [µmol/min])
		PassiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|Sum of passive process rates(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Absorption of liquid
	IsFixed: False
	Value: 0.0459460674607501 [1/min]
	Formula: (k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)
		alpha: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Fractional steady state fill level(0.064841)
		k: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Intestinal transit rate (absolute)(0.0473069588772936 [1/min])
		inflow: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Secretion of liquid(0.00052687876732521 [l/min])
		V: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Volume(0.298396538101155 [l])
		alpha_p: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Fractional steady state fill level(0.064841)
		k_p: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Intestinal transit rate (absolute)(0.0473069588772936 [1/min])
		V_p: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Volume(0.416443516615261 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Distal radius
	IsFixed: False
	Value: 0.1005520763 [dm]
	Formula: r2_p0 + Height*r2_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r2_p0: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|r2_p0(-0.0012940725 [dm])
		r2_p1: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|r2_p1(0.005786713)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Effective surface area
	IsFixed: False
	Value: 788.634160322344 [dm²]
	Formula: Ageom*AeffFactor*AeffVariabilityFactor
		AeffFactor: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Effective surface area enhancement factor(146.565)
		Ageom: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Geometric surface area(5.380780938588 [dm²])
		AeffVariabilityFactor: PBPK_model_human_Ab|Organism|Lumen|Effective surface area variability factor(1.00000000260982)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|FillLevelFlag
	IsFixed: False
	Value: 1
	Formula: (FillLevel<0.9?1:1/(1+exp((FillLevel-1)/0.01)))
		FillLevel: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Fraction of geometric volume filled with liquid(0.064841)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Fraction of geometric volume filled with liquid
	IsFixed: False
	Value: 0.064841
	Formula: Liquid/V
		Liquid: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Liquid(0.019348329927017 [l])
		V: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Volume(0.298396538101155 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Length
	IsFixed: False
	Value: 7.7425093078 [dm]
	Formula: L_p0 + Height*L_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		L_p0: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|L_p0(-0.0996435866 [dm])
		L_p1: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|L_p1(0.445576869)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Geometric surface area
	IsFixed: False
	Value: 5.380780938588 [dm²]
	Formula: PI*(r1+r2)*L
		r2: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Distal radius(0.1005520763 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Length(7.7425093078 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Proximal radius(0.1206624809 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Liquid
	IsFixed: False
	Value: 0.019348329927017 [l]
	Formula: V*SteadyStateFillLevel
		SteadyStateFillLevel: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Fractional steady state fill level(0.064841)
		V: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Volume(0.298396538101155 [l])
	RHS_Formula: OralApplicationsEnabled ? LT_uil - LT_lil + Inflow*FillLevelFlag - Outflow*Liquid : 0
		Outflow: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Absorption of liquid(0.0459460674607501 [1/min])
		FillLevelFlag: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|FillLevelFlag(1)
		Liquid: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Liquid(0.019348329927017 [l])
		LT_lil: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Liquid transfer rate(0.000915310648201703 [l/min])
		Inflow: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Secretion of liquid(0.00052687876732521 [l/min])
		LT_uil: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Liquid transfer rate(0.00127741155295607 [l/min])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Liquid transfer rate
	IsFixed: False
	Value: 0.000915310648201703 [l/min]
	Formula: w*Liquid*FillLevelFlagNext
		w: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Intestinal transit rate (absolute)(0.0473069588772936 [1/min])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Liquid(0.019348329927017 [l])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|Caecum|FillLevelFlag(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Proximal radius
	IsFixed: False
	Value: 0.1206624809 [dm]
	Formula: r1_p0 + Height*r1_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r1_p0: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|r1_p0(-0.0015528871 [dm])
		r1_p1: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|r1_p1(0.006944055)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Secretion of liquid
	IsFixed: False
	Value: 0.00052687876732521 [l/min]
	Formula: 0.0017657*V
		V: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Volume(0.298396538101155 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Thickness of gut wall
	IsFixed: False
	Value: 0.0200575758678131 [dm]
	Formula: Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		Thickness_p1: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Thickness_p1(-0.0148137399 [dm])
		Thickness_p2: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Thickness_p2(0.0350288649 [dm])
		Thickness_p3: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Thickness_p3(-0.30705627 [1/dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Volume
	IsFixed: False
	Value: 0.298396538101155 [l]
	Formula: PI*(r1*r1+r1*r2+r2*r2)/3*L
		r2: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Distal radius(0.1005520763 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Length(7.7425093078 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Proximal radius(0.1206624809 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Volume of protein container
	IsFixed: False
	Value: 0.298396538101155 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Volume(0.298396538101155 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Intestinal transit rate (absolute)
	IsFixed: False
	Value: 0.0473069588772936 [1/min]
	Formula: LuminalVelocity/SITT_fact
		LuminalVelocity: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Intestinal transit rate(3.3745 [1/min])
		SITT_fact: PBPK_model_human_Ab|Organism|SmallIntestine|Small intestinal transit time factor(71.3320001979601)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Volume (gut wall)
	IsFixed: False
	Value: 0.11301698217897 [l]
	Formula: V_Intestine * 0.156
		V_Intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Thickness_p3
	IsFixed: False
	Value: -0.30705627 [1/dm]
	Formula: -0.30705627

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Thickness_p2
	IsFixed: False
	Value: 0.0350288649 [dm]
	Formula: 0.0350288649

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Thickness_p1
	IsFixed: False
	Value: -0.0148137399 [dm]
	Formula: -0.0148137399

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|r2_p1
	IsFixed: False
	Value: 0.005786713
	Formula: 0.005786713

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|r2_p0
	IsFixed: False
	Value: -0.0012940725 [dm]
	Formula: -0.0012940725

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|r1_p1
	IsFixed: False
	Value: 0.006944055
	Formula: 0.006944055

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|r1_p0
	IsFixed: False
	Value: -0.0015528871 [dm]
	Formula: -0.0015528871

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|pH
	IsFixed: False
	Value: 7.4583
	Formula: 7.4583

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Microvilli factor
	IsFixed: False
	Value: 25
	Formula: 25

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|L_p1
	IsFixed: False
	Value: 0.445576869
	Formula: 0.445576869

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|L_p0
	IsFixed: False
	Value: -0.0996435866 [dm]
	Formula: -0.0996435866

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Intestinal transit rate
	IsFixed: False
	Value: 3.3745 [1/min]
	Formula: 3.3745

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Fractional steady state fill level
	IsFixed: False
	Value: 0.064841
	Formula: 0.064841

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Effective surface area enhancement factor
	IsFixed: False
	Value: 146.565
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Volume(0.298396538101155 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|Oral mass absorbed segment
	IsFixed: False
	Value: 0 [µmol]
	Formula: 0
	RHS_Formula: PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)
		ActiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_pls|CDA1|Sum of active process rates(0 [µmol/min])
		ActiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|Sum of active process rates(0 [µmol/min])
		PassiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_pls|CDA1|Sum of passive process rates(0 [µmol/min])
		PassiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|Sum of passive process rates(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|pH(7.4583)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|pH(7.4583)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|pH(7.4583)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|Solubility
	IsFixed: False
	Value: 0.000999 [kg/l]
	Formula: Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor
		Solubility_pKa_pH_Factor: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|Solubility_pKa_pH_Factor(1)
		Solubility: PBPK_model_human_Ab|CDA1|Solubility at reference pH(0.000999 [kg/l])
		Solubility_pKa_REFpH_Factor: PBPK_model_human_Ab|CDA1|Solubility_pKa_pH_Factor(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|Solubility_pKa_pH_Factor
	IsFixed: False
	Value: 1
	Formula: K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)
		K1: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_K8(0)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		base: PBPK_model_human_Ab|CDA1|Solubility gain per charge(1000)

Parameter: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Volume (gut wall)
	IsFixed: False
	Value: 0.0349396477595736 [l]
	Formula: V_Intestine * 0.08470588
		V_Intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Volume of protein container
	IsFixed: False
	Value: 0.217489335565001 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lumen|Caecum|Volume(0.217489335565001 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Thickness of gut wall
	IsFixed: False
	Value: 0.0266806331014496 [dm]
	Formula: Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		Thickness_p1: PBPK_model_human_Ab|Organism|Lumen|Caecum|Thickness_p1(-0.00877 [dm])
		Thickness_p2: PBPK_model_human_Ab|Organism|Lumen|Caecum|Thickness_p2(0.0446435379 [dm])
		Thickness_p3: PBPK_model_human_Ab|Organism|Lumen|Caecum|Thickness_p3(-0.0897885 [1/dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Absorption of liquid
	IsFixed: False
	Value: 0.694085095490314 [1/min]
	Formula: (k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)
		alpha: PBPK_model_human_Ab|Organism|Lumen|Caecum|Fractional steady state fill level(0.0060009)
		k: PBPK_model_human_Ab|Organism|Lumen|Caecum|Intestinal transit rate (absolute)(0.00723156893249226 [1/min])
		inflow: PBPK_model_human_Ab|Organism|Lumen|Caecum|Secretion of liquid(0 [l/min])
		V: PBPK_model_human_Ab|Organism|Lumen|Caecum|Volume(0.217489335565001 [l])
		alpha_p: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Fractional steady state fill level(0.064841)
		k_p: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Intestinal transit rate (absolute)(0.0473069588772936 [1/min])
		V_p: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Volume(0.298396538101155 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Volume
	IsFixed: False
	Value: 0.217489335565001 [l]
	Formula: PI*(r1*r1+r1*r2+r2*r2)/3*L
		r2: PBPK_model_human_Ab|Organism|Lumen|Caecum|Distal radius(0.3430963586 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|Caecum|Length(0.5881063603 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|Caecum|Proximal radius(0.3430963586 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Distal radius
	IsFixed: False
	Value: 0.3430963586 [dm]
	Formula: r2_p0 + Height*r2_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r2_p0: PBPK_model_human_Ab|Organism|Lumen|Caecum|r2_p0(0.067256381 [dm])
		r2_p1: PBPK_model_human_Ab|Organism|Lumen|Caecum|r2_p1(0.015672726)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Effective surface area
	IsFixed: False
	Value: 2.28204581730992 [dm²]
	Formula: Ageom*AeffFactor*AeffVariabilityFactor
		AeffFactor: PBPK_model_human_Ab|Organism|Lumen|Caecum|Effective surface area enhancement factor(1.8)
		Ageom: PBPK_model_human_Ab|Organism|Lumen|Caecum|Geometric surface area(1.2678032285301 [dm²])
		AeffVariabilityFactor: PBPK_model_human_Ab|Organism|Lumen|Effective surface area variability factor(1.00000000260982)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|FillLevelFlag
	IsFixed: False
	Value: 1
	Formula: (FillLevel<0.9?1:1/(1+exp((FillLevel-1)/0.01)))
		FillLevel: PBPK_model_human_Ab|Organism|Lumen|Caecum|Fraction of geometric volume filled with liquid(0.0060009)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Fraction of geometric volume filled with liquid
	IsFixed: False
	Value: 0.0060009
	Formula: Liquid/V
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Caecum|Liquid(0.00130513175379201 [l])
		V: PBPK_model_human_Ab|Organism|Lumen|Caecum|Volume(0.217489335565001 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Geometric surface area
	IsFixed: False
	Value: 1.2678032285301 [dm²]
	Formula: PI*(r1+r2)*L
		r2: PBPK_model_human_Ab|Organism|Lumen|Caecum|Distal radius(0.3430963586 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|Caecum|Length(0.5881063603 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|Caecum|Proximal radius(0.3430963586 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Intestinal transit rate (absolute)
	IsFixed: False
	Value: 0.00723156893249226 [1/min]
	Formula: LuminalVelocity/LITT_fact
		LuminalVelocity: PBPK_model_human_Ab|Organism|Lumen|Caecum|Intestinal transit rate(18.3333 [1/min])
		LITT_fact: PBPK_model_human_Ab|Organism|LargeIntestine|Large intestinal transit time factor(2535.176)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Length
	IsFixed: False
	Value: 0.5881063603 [dm]
	Formula: L_p0 + Height*L_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		L_p0: PBPK_model_human_Ab|Organism|Lumen|Caecum|L_p0(0.1152851235 [dm])
		L_p1: PBPK_model_human_Ab|Organism|Lumen|Caecum|L_p1(0.026864843)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Liquid
	IsFixed: False
	Value: 0.00130513175379201 [l]
	Formula: V*SteadyStateFillLevel
		SteadyStateFillLevel: PBPK_model_human_Ab|Organism|Lumen|Caecum|Fractional steady state fill level(0.0060009)
		V: PBPK_model_human_Ab|Organism|Lumen|Caecum|Volume(0.217489335565001 [l])
	RHS_Formula: OralApplicationsEnabled ? LT_lil - LT_cae + Inflow*FillLevelFlag - Outflow*Liquid : 0
		Outflow: PBPK_model_human_Ab|Organism|Lumen|Caecum|Absorption of liquid(0.694085095490314 [1/min])
		FillLevelFlag: PBPK_model_human_Ab|Organism|Lumen|Caecum|FillLevelFlag(1)
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Caecum|Liquid(0.00130513175379201 [l])
		LT_cae: PBPK_model_human_Ab|Organism|Lumen|Caecum|Liquid transfer rate(9.43815024353147E-06 [l/min])
		Inflow: PBPK_model_human_Ab|Organism|Lumen|Caecum|Secretion of liquid(0 [l/min])
		LT_lil: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Liquid transfer rate(0.000915310648201703 [l/min])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Liquid transfer rate
	IsFixed: False
	Value: 9.43815024353147E-06 [l/min]
	Formula: w*Liquid*FillLevelFlagNext
		w: PBPK_model_human_Ab|Organism|Lumen|Caecum|Intestinal transit rate (absolute)(0.00723156893249226 [1/min])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Caecum|Liquid(0.00130513175379201 [l])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|FillLevelFlag(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Proximal radius
	IsFixed: False
	Value: 0.3430963586 [dm]
	Formula: r1_p0 + Height*r1_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r1_p0: PBPK_model_human_Ab|Organism|Lumen|Caecum|r1_p0(0.067256381 [dm])
		r1_p1: PBPK_model_human_Ab|Organism|Lumen|Caecum|r1_p1(0.015672726)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Secretion of liquid
	IsFixed: False
	Value: 0 [l/min]
	Formula: 0*V
		V: PBPK_model_human_Ab|Organism|Lumen|Caecum|Volume(0.217489335565001 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|pH
	IsFixed: False
	Value: 5.7
	Formula: 5.7

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Fractional steady state fill level
	IsFixed: False
	Value: 0.0060009
	Formula: 0.0060009

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Intestinal transit rate
	IsFixed: False
	Value: 18.3333 [1/min]
	Formula: 18.3333

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Thickness_p3
	IsFixed: False
	Value: -0.0897885 [1/dm]
	Formula: -0.0897885

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Thickness_p2
	IsFixed: False
	Value: 0.0446435379 [dm]
	Formula: 0.0446435379

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Thickness_p1
	IsFixed: False
	Value: -0.00877 [dm]
	Formula: -0.00877

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|r2_p1
	IsFixed: False
	Value: 0.015672726
	Formula: 0.015672726

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|r2_p0
	IsFixed: False
	Value: 0.067256381 [dm]
	Formula: 0.067256381

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|r1_p0
	IsFixed: False
	Value: 0.067256381 [dm]
	Formula: 0.067256381

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Microvilli factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|L_p1
	IsFixed: False
	Value: 0.026864843
	Formula: 0.026864843

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|L_p0
	IsFixed: False
	Value: 0.1152851235 [dm]
	Formula: 0.1152851235

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|r1_p1
	IsFixed: False
	Value: 0.015672726
	Formula: 0.015672726

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|Effective surface area enhancement factor
	IsFixed: False
	Value: 1.8
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lumen|Caecum|Volume(0.217489335565001 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|Solubility
	IsFixed: False
	Value: 0.000999 [kg/l]
	Formula: Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor
		Solubility_pKa_pH_Factor: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|Solubility_pKa_pH_Factor(1)
		Solubility: PBPK_model_human_Ab|CDA1|Solubility at reference pH(0.000999 [kg/l])
		Solubility_pKa_REFpH_Factor: PBPK_model_human_Ab|CDA1|Solubility_pKa_pH_Factor(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|Solubility_pKa_pH_Factor
	IsFixed: False
	Value: 1
	Formula: K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)
		K1: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_K8(0)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		base: PBPK_model_human_Ab|CDA1|Solubility gain per charge(1000)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|Oral mass absorbed segment
	IsFixed: False
	Value: 0 [µmol]
	Formula: 0
	RHS_Formula: PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)
		ActiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_pls|CDA1|Sum of active process rates(0 [µmol/min])
		ActiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|Sum of active process rates(0 [µmol/min])
		PassiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_pls|CDA1|Sum of passive process rates(0 [µmol/min])
		PassiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|Sum of passive process rates(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|Caecum|pH(5.7)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|Caecum|pH(5.7)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|Caecum|pH(5.7)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Volume of protein container
	IsFixed: False
	Value: 0.608168079265237 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Volume(0.608168079265237 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Length
	IsFixed: False
	Value: 1.6445289817 [dm]
	Formula: L_p0 + Height*L_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		L_p0: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|L_p0(0.3117189273 [dm])
		L_p1: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|L_p1(0.075727844)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Absorption of liquid
	IsFixed: False
	Value: 0.162660340501137 [1/min]
	Formula: (k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)
		alpha: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Fractional steady state fill level(0.0060009)
		k: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Intestinal transit rate (absolute)(0.00394449931681272 [1/min])
		inflow: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Secretion of liquid(0.000598595513697603 [l/min])
		V: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Volume(0.608168079265237 [l])
		alpha_p: PBPK_model_human_Ab|Organism|Lumen|Caecum|Fractional steady state fill level(0.0060009)
		k_p: PBPK_model_human_Ab|Organism|Lumen|Caecum|Intestinal transit rate (absolute)(0.00723156893249226 [1/min])
		V_p: PBPK_model_human_Ab|Organism|Lumen|Caecum|Volume(0.217489335565001 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Distal radius
	IsFixed: False
	Value: 0.3430963586 [dm]
	Formula: r2_p0 + Height*r2_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r2_p0: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|r2_p0(0.067256381 [dm])
		r2_p1: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|r2_p1(0.015672726)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Effective surface area
	IsFixed: False
	Value: 8.86293406514235 [dm²]
	Formula: Ageom*AeffFactor*AeffVariabilityFactor
		AeffFactor: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Effective surface area enhancement factor(2.5)
		Ageom: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Geometric surface area(3.54517361680467 [dm²])
		AeffVariabilityFactor: PBPK_model_human_Ab|Organism|Lumen|Effective surface area variability factor(1.00000000260982)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|FillLevelFlag
	IsFixed: False
	Value: 1
	Formula: (FillLevel<0.9?1:1/(1+exp((FillLevel-1)/0.01)))
		FillLevel: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Fraction of geometric volume filled with liquid(0.0060009)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Fraction of geometric volume filled with liquid
	IsFixed: False
	Value: 0.0060009
	Formula: Liquid/V
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Liquid(0.00364955582686276 [l])
		V: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Volume(0.608168079265237 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Intestinal transit rate (absolute)
	IsFixed: False
	Value: 0.00394449931681272 [1/min]
	Formula: LuminalVelocity/LITT_fact
		LuminalVelocity: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Intestinal transit rate(10 [1/min])
		LITT_fact: PBPK_model_human_Ab|Organism|LargeIntestine|Large intestinal transit time factor(2535.176)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Liquid
	IsFixed: False
	Value: 0.00364955582686276 [l]
	Formula: V*SteadyStateFillLevel
		SteadyStateFillLevel: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Fractional steady state fill level(0.0060009)
		V: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Volume(0.608168079265237 [l])
	RHS_Formula: OralApplicationsEnabled ? LT_cae - LT_colasc + Inflow*FillLevelFlag - Outflow*Liquid : 0
		Outflow: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Absorption of liquid(0.162660340501137 [1/min])
		FillLevelFlag: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|FillLevelFlag(1)
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Liquid(0.00364955582686276 [l])
		LT_colasc: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Liquid transfer rate(1.439567046573E-05 [l/min])
		Inflow: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Secretion of liquid(0.000598595513697603 [l/min])
		LT_cae: PBPK_model_human_Ab|Organism|Lumen|Caecum|Liquid transfer rate(9.43815024353147E-06 [l/min])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Liquid transfer rate
	IsFixed: False
	Value: 1.439567046573E-05 [l/min]
	Formula: w*Liquid*FillLevelFlagNext
		w: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Intestinal transit rate (absolute)(0.00394449931681272 [1/min])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Liquid(0.00364955582686276 [l])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|FillLevelFlag(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Proximal radius
	IsFixed: False
	Value: 0.3430963586 [dm]
	Formula: r1_p0 + Height*r1_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r1_p0: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|r1_p0(0.067256381 [dm])
		r1_p1: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|r1_p1(0.015672726)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Secretion of liquid
	IsFixed: False
	Value: 0.000598595513697603 [l/min]
	Formula: 0.00098426*V
		V: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Volume(0.608168079265237 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Thickness of gut wall
	IsFixed: False
	Value: 0.0168329998029135 [dm]
	Formula: Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		Thickness_p1: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Thickness_p1(-0.00554 [dm])
		Thickness_p2: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Thickness_p2(0.0280138174 [dm])
		Thickness_p3: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Thickness_p3(-0.09106073 [1/dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Volume
	IsFixed: False
	Value: 0.608168079265237 [l]
	Formula: PI*(r1*r1+r1*r2+r2*r2)/3*L
		r2: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Distal radius(0.3430963586 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Length(1.6445289817 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Proximal radius(0.3430963586 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Volume (gut wall)
	IsFixed: False
	Value: 0.0640560236424314 [l]
	Formula: V_Intestine * 0.15529412
		V_Intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Geometric surface area
	IsFixed: False
	Value: 3.54517361680467 [dm²]
	Formula: PI*(r1+r2)*L
		r2: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Distal radius(0.3430963586 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Length(1.6445289817 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Proximal radius(0.3430963586 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Microvilli factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|L_p1
	IsFixed: False
	Value: 0.075727844
	Formula: 0.075727844

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|L_p0
	IsFixed: False
	Value: 0.3117189273 [dm]
	Formula: 0.3117189273

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Intestinal transit rate
	IsFixed: False
	Value: 10 [1/min]
	Formula: 10

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|pH
	IsFixed: False
	Value: 5.6
	Formula: 5.6

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Fractional steady state fill level
	IsFixed: False
	Value: 0.0060009
	Formula: 0.0060009

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Thickness_p3
	IsFixed: False
	Value: -0.09106073 [1/dm]
	Formula: -0.09106073

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Thickness_p2
	IsFixed: False
	Value: 0.0280138174 [dm]
	Formula: 0.0280138174

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Thickness_p1
	IsFixed: False
	Value: -0.00554 [dm]
	Formula: -0.00554

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|r2_p1
	IsFixed: False
	Value: 0.015672726
	Formula: 0.015672726

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|r2_p0
	IsFixed: False
	Value: 0.067256381 [dm]
	Formula: 0.067256381

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|r1_p1
	IsFixed: False
	Value: 0.015672726
	Formula: 0.015672726

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|r1_p0
	IsFixed: False
	Value: 0.067256381 [dm]
	Formula: 0.067256381

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Effective surface area enhancement factor
	IsFixed: False
	Value: 2.5
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Volume(0.608168079265237 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|Oral mass absorbed segment
	IsFixed: False
	Value: 0 [µmol]
	Formula: 0
	RHS_Formula: PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)
		ActiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_pls|CDA1|Sum of active process rates(0 [µmol/min])
		ActiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|Sum of active process rates(0 [µmol/min])
		PassiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_pls|CDA1|Sum of passive process rates(0 [µmol/min])
		PassiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|Sum of passive process rates(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|pH(5.6)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|pH(5.6)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|pH(5.6)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|Solubility
	IsFixed: False
	Value: 0.000999 [kg/l]
	Formula: Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor
		Solubility_pKa_pH_Factor: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|Solubility_pKa_pH_Factor(1)
		Solubility: PBPK_model_human_Ab|CDA1|Solubility at reference pH(0.000999 [kg/l])
		Solubility_pKa_REFpH_Factor: PBPK_model_human_Ab|CDA1|Solubility_pKa_pH_Factor(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|Solubility_pKa_pH_Factor
	IsFixed: False
	Value: 1
	Formula: K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)
		K1: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_K8(0)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		base: PBPK_model_human_Ab|CDA1|Solubility gain per charge(1000)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Volume
	IsFixed: False
	Value: 0.756567144275064 [l]
	Formula: PI*(r1*r1+r1*r2+r2*r2)/3*L
		r2: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Distal radius(0.1960550545 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Length(3.2337004261 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Proximal radius(0.3430963586 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Effective surface area
	IsFixed: False
	Value: 13.6930569430801 [dm²]
	Formula: Ageom*AeffFactor*AeffVariabilityFactor
		AeffFactor: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Effective surface area enhancement factor(2.5)
		Ageom: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Geometric surface area(5.47722276293745 [dm²])
		AeffVariabilityFactor: PBPK_model_human_Ab|Organism|Lumen|Effective surface area variability factor(1.00000000260982)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|FillLevelFlag
	IsFixed: False
	Value: 1
	Formula: (FillLevel<0.9?1:1/(1+exp((FillLevel-1)/0.01)))
		FillLevel: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Fraction of geometric volume filled with liquid(0.0060009)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Fraction of geometric volume filled with liquid
	IsFixed: False
	Value: 0.0060009
	Formula: Liquid/V
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Liquid(0.00454008377608023 [l])
		V: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Volume(0.756567144275064 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Geometric surface area
	IsFixed: False
	Value: 5.47722276293745 [dm²]
	Formula: PI*(r1+r2)*L
		r2: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Distal radius(0.1960550545 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Length(3.2337004261 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Proximal radius(0.3430963586 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Intestinal transit rate (absolute)
	IsFixed: False
	Value: 0.00131481995727318 [1/min]
	Formula: LuminalVelocity/LITT_fact
		LuminalVelocity: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Intestinal transit rate(3.3333 [1/min])
		LITT_fact: PBPK_model_human_Ab|Organism|LargeIntestine|Large intestinal transit time factor(2535.176)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Length
	IsFixed: False
	Value: 3.2337004261 [dm]
	Formula: L_p0 + Height*L_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		L_p0: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|L_p0(0.6886041141 [dm])
		L_p1: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|L_p1(0.144607745)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Liquid
	IsFixed: False
	Value: 0.00454008377608023 [l]
	Formula: V*SteadyStateFillLevel
		SteadyStateFillLevel: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Fractional steady state fill level(0.0060009)
		V: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Volume(0.756567144275064 [l])
	RHS_Formula: OralApplicationsEnabled ? LT_colasc - LT_coltrans + Inflow*FillLevelFlag - Outflow*Liquid : 0
		Outflow: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Absorption of liquid(0.0356592369018398 [1/min])
		FillLevelFlag: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|FillLevelFlag(1)
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Liquid(0.00454008377608023 [l])
		LT_coltrans: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Liquid transfer rate(5.96939275648248E-06 [l/min])
		Inflow: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Secretion of liquid(0.000153469645216197 [l/min])
		LT_colasc: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Liquid transfer rate(1.439567046573E-05 [l/min])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Liquid transfer rate
	IsFixed: False
	Value: 5.96939275648248E-06 [l/min]
	Formula: w*Liquid*FillLevelFlagNext
		w: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Intestinal transit rate (absolute)(0.00131481995727318 [1/min])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Liquid(0.00454008377608023 [l])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|FillLevelFlag(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Proximal radius
	IsFixed: False
	Value: 0.3430963586 [dm]
	Formula: r1_p0 + Height*r1_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r1_p0: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|r1_p0(0.067256381 [dm])
		r1_p1: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|r1_p1(0.015672726)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Secretion of liquid
	IsFixed: False
	Value: 0.000153469645216197 [l/min]
	Formula: 0.00020285*V
		V: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Volume(0.756567144275064 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Volume (gut wall)
	IsFixed: False
	Value: 0.131994228536007 [l]
	Formula: V_Intestine * 0.32
		V_Intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Volume of protein container
	IsFixed: False
	Value: 0.756567144275064 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Volume(0.756567144275064 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Thickness of gut wall
	IsFixed: False
	Value: 0.0232585538759707 [dm]
	Formula: Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		Thickness_p1: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Thickness_p1(-0.0076 [dm])
		Thickness_p2: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Thickness_p2(0.0394956146 [dm])
		Thickness_p3: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Thickness_p3(-0.08637087 [1/dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Distal radius
	IsFixed: False
	Value: 0.1960550545 [dm]
	Formula: r2_p0 + Height*r2_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r2_p0: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|r2_p0(0.0384322177 [dm])
		r2_p1: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|r2_p1(0.008955843)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Absorption of liquid
	IsFixed: False
	Value: 0.0356592369018398 [1/min]
	Formula: (k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)
		alpha: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Fractional steady state fill level(0.0060009)
		k: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Intestinal transit rate (absolute)(0.00131481995727318 [1/min])
		inflow: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Secretion of liquid(0.000153469645216197 [l/min])
		V: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Volume(0.756567144275064 [l])
		alpha_p: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Fractional steady state fill level(0.0060009)
		k_p: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Intestinal transit rate (absolute)(0.00394449931681272 [1/min])
		V_p: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Volume(0.608168079265237 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Fractional steady state fill level
	IsFixed: False
	Value: 0.0060009
	Formula: 0.0060009

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Thickness_p3
	IsFixed: False
	Value: -0.08637087 [1/dm]
	Formula: -0.08637087

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Thickness_p2
	IsFixed: False
	Value: 0.0394956146 [dm]
	Formula: 0.0394956146

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Thickness_p1
	IsFixed: False
	Value: -0.0076 [dm]
	Formula: -0.0076

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|r2_p1
	IsFixed: False
	Value: 0.008955843
	Formula: 0.008955843

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|r2_p0
	IsFixed: False
	Value: 0.0384322177 [dm]
	Formula: 0.0384322177

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|r1_p1
	IsFixed: False
	Value: 0.015672726
	Formula: 0.015672726

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|r1_p0
	IsFixed: False
	Value: 0.067256381 [dm]
	Formula: 0.067256381

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|pH
	IsFixed: False
	Value: 5.7
	Formula: 5.7

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Microvilli factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|L_p1
	IsFixed: False
	Value: 0.144607745
	Formula: 0.144607745

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Intestinal transit rate
	IsFixed: False
	Value: 3.3333 [1/min]
	Formula: 3.3333

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|L_p0
	IsFixed: False
	Value: 0.6886041141 [dm]
	Formula: 0.6886041141

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Effective surface area enhancement factor
	IsFixed: False
	Value: 2.5
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Volume(0.756567144275064 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|Oral mass absorbed segment
	IsFixed: False
	Value: 0 [µmol]
	Formula: 0
	RHS_Formula: PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)
		ActiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_pls|CDA1|Sum of active process rates(0 [µmol/min])
		ActiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|Sum of active process rates(0 [µmol/min])
		PassiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_pls|CDA1|Sum of passive process rates(0 [µmol/min])
		PassiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|Sum of passive process rates(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|pH(5.7)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|pH(5.7)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|pH(5.7)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|Solubility
	IsFixed: False
	Value: 0.000999 [kg/l]
	Formula: Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor
		Solubility_pKa_pH_Factor: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|Solubility_pKa_pH_Factor(1)
		Solubility: PBPK_model_human_Ab|CDA1|Solubility at reference pH(0.000999 [kg/l])
		Solubility_pKa_REFpH_Factor: PBPK_model_human_Ab|CDA1|Solubility_pKa_pH_Factor(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|Solubility_pKa_pH_Factor
	IsFixed: False
	Value: 1
	Formula: K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)
		K1: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_K8(0)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		base: PBPK_model_human_Ab|CDA1|Solubility gain per charge(1000)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Liquid transfer rate
	IsFixed: False
	Value: 3.08215859051085E-06 [l/min]
	Formula: w*Liquid*FillLevelFlagNext
		w: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Intestinal transit rate (absolute)(0.00197224965840636 [1/min])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Liquid(0.00156276289737139 [l])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|FillLevelFlag(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Proximal radius
	IsFixed: False
	Value: 0.1960550545 [dm]
	Formula: r1_p0 + Height*r1_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r1_p0: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|r1_p0(0.0384322177 [dm])
		r1_p1: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|r1_p1(0.008955843)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Secretion of liquid
	IsFixed: False
	Value: 5.99073433837115E-05 [l/min]
	Formula: 0.00023004*V
		V: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Volume(0.260421419682279 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Thickness of gut wall
	IsFixed: False
	Value: 0.035965107966664 [dm]
	Formula: Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		Thickness_p1: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Thickness_p1(-0.0118 [dm])
		Thickness_p2: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Thickness_p2(0.0601543776 [dm])
		Thickness_p3: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Thickness_p3(-0.08977747 [1/dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Volume
	IsFixed: False
	Value: 0.260421419682279 [l]
	Formula: PI*(r1*r1+r1*r2+r2*r2)/3*L
		r2: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Distal radius(0.1960550545 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Length(2.1566056703 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Proximal radius(0.1960550545 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Volume (gut wall)
	IsFixed: False
	Value: 0.0989956714020051 [l]
	Formula: V_Intestine * 0.24
		V_Intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Volume of protein container
	IsFixed: False
	Value: 0.260421419682279 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Volume(0.260421419682279 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Intestinal transit rate (absolute)
	IsFixed: False
	Value: 0.00197224965840636 [1/min]
	Formula: LuminalVelocity/LITT_fact
		LuminalVelocity: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Intestinal transit rate(5 [1/min])
		LITT_fact: PBPK_model_human_Ab|Organism|LargeIntestine|Large intestinal transit time factor(2535.176)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Liquid
	IsFixed: False
	Value: 0.00156276289737139 [l]
	Formula: V*SteadyStateFillLevel
		SteadyStateFillLevel: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Fractional steady state fill level(0.0060009)
		V: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Volume(0.260421419682279 [l])
	RHS_Formula: OralApplicationsEnabled ? LT_coltrans - LT_coldesc + Inflow*FillLevelFlag - Outflow*Liquid : 0
		Outflow: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Absorption of liquid(0.0401817688756915 [1/min])
		FillLevelFlag: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|FillLevelFlag(1)
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Liquid(0.00156276289737139 [l])
		LT_coldesc: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Liquid transfer rate(3.08215859051085E-06 [l/min])
		Inflow: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Secretion of liquid(5.99073433837115E-05 [l/min])
		LT_coltrans: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Liquid transfer rate(5.96939275648248E-06 [l/min])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Length
	IsFixed: False
	Value: 2.1566056703 [dm]
	Formula: L_p0 + Height*L_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		L_p0: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|L_p0(0.4227543951 [dm])
		L_p1: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|L_p1(0.098514277)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Absorption of liquid
	IsFixed: False
	Value: 0.0401817688756915 [1/min]
	Formula: (k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)
		alpha: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Fractional steady state fill level(0.0060009)
		k: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Intestinal transit rate (absolute)(0.00197224965840636 [1/min])
		inflow: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Secretion of liquid(5.99073433837115E-05 [l/min])
		V: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Volume(0.260421419682279 [l])
		alpha_p: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Fractional steady state fill level(0.0060009)
		k_p: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Intestinal transit rate (absolute)(0.00131481995727318 [1/min])
		V_p: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Volume(0.756567144275064 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Distal radius
	IsFixed: False
	Value: 0.1960550545 [dm]
	Formula: r2_p0 + Height*r2_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r2_p0: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|r2_p0(0.0384322177 [dm])
		r2_p1: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|r2_p1(0.008955843)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Effective surface area
	IsFixed: False
	Value: 6.6415380370092 [dm²]
	Formula: Ageom*AeffFactor*AeffVariabilityFactor
		AeffFactor: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Effective surface area enhancement factor(2.5)
		Ageom: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Geometric surface area(2.65661520787039 [dm²])
		AeffVariabilityFactor: PBPK_model_human_Ab|Organism|Lumen|Effective surface area variability factor(1.00000000260982)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|FillLevelFlag
	IsFixed: False
	Value: 1
	Formula: (FillLevel<0.9?1:1/(1+exp((FillLevel-1)/0.01)))
		FillLevel: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Fraction of geometric volume filled with liquid(0.0060009)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Fraction of geometric volume filled with liquid
	IsFixed: False
	Value: 0.0060009
	Formula: Liquid/V
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Liquid(0.00156276289737139 [l])
		V: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Volume(0.260421419682279 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Geometric surface area
	IsFixed: False
	Value: 2.65661520787039 [dm²]
	Formula: PI*(r1+r2)*L
		r2: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Distal radius(0.1960550545 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Length(2.1566056703 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Proximal radius(0.1960550545 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Thickness_p2
	IsFixed: False
	Value: 0.0601543776 [dm]
	Formula: 0.0601543776

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Fractional steady state fill level
	IsFixed: False
	Value: 0.0060009
	Formula: 0.0060009

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Thickness_p1
	IsFixed: False
	Value: -0.0118 [dm]
	Formula: -0.0118

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Thickness_p3
	IsFixed: False
	Value: -0.08977747 [1/dm]
	Formula: -0.08977747

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Intestinal transit rate
	IsFixed: False
	Value: 5 [1/min]
	Formula: 5

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|L_p0
	IsFixed: False
	Value: 0.4227543951 [dm]
	Formula: 0.4227543951

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|L_p1
	IsFixed: False
	Value: 0.098514277
	Formula: 0.098514277

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Microvilli factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|pH
	IsFixed: False
	Value: 6.6
	Formula: 6.6

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|r1_p0
	IsFixed: False
	Value: 0.0384322177 [dm]
	Formula: 0.0384322177

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|r2_p1
	IsFixed: False
	Value: 0.008955843
	Formula: 0.008955843

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|r2_p0
	IsFixed: False
	Value: 0.0384322177 [dm]
	Formula: 0.0384322177

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|r1_p1
	IsFixed: False
	Value: 0.008955843
	Formula: 0.008955843

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Effective surface area enhancement factor
	IsFixed: False
	Value: 2.5
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Volume(0.260421419682279 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|pH(6.6)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|Solubility
	IsFixed: False
	Value: 0.000999 [kg/l]
	Formula: Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor
		Solubility_pKa_pH_Factor: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|Solubility_pKa_pH_Factor(1)
		Solubility: PBPK_model_human_Ab|CDA1|Solubility at reference pH(0.000999 [kg/l])
		Solubility_pKa_REFpH_Factor: PBPK_model_human_Ab|CDA1|Solubility_pKa_pH_Factor(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|Solubility_pKa_pH_Factor
	IsFixed: False
	Value: 1
	Formula: K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)
		K1: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_K8(0)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		base: PBPK_model_human_Ab|CDA1|Solubility gain per charge(1000)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|pH(6.6)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|pH(6.6)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|Oral mass absorbed segment
	IsFixed: False
	Value: 0 [µmol]
	Formula: 0
	RHS_Formula: PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)
		ActiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_pls|CDA1|Sum of active process rates(0 [µmol/min])
		ActiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|Sum of active process rates(0 [µmol/min])
		PassiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_pls|CDA1|Sum of passive process rates(0 [µmol/min])
		PassiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|Sum of passive process rates(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Effective surface area
	IsFixed: False
	Value: 8.21854246352471 [dm²]
	Formula: Ageom*AeffFactor*AeffVariabilityFactor
		AeffFactor: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Effective surface area enhancement factor(2.5)
		Ageom: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Geometric surface area(3.28741697683031 [dm²])
		AeffVariabilityFactor: PBPK_model_human_Ab|Organism|Lumen|Effective surface area variability factor(1.00000000260982)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Distal radius
	IsFixed: False
	Value: 0.1960550545 [dm]
	Formula: r2_p0 + Height*r2_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r2_p0: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|r2_p0(0.0384322177 [dm])
		r2_p1: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|r2_p1(0.008955843)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|FillLevelFlag
	IsFixed: False
	Value: 1
	Formula: (FillLevel<0.9?1:1/(1+exp((FillLevel-1)/0.01)))
		FillLevel: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Fraction of geometric volume filled with liquid(0.0060009)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Fraction of geometric volume filled with liquid
	IsFixed: False
	Value: 0.0060009
	Formula: Liquid/V
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Liquid(0.00193383417529163 [l])
		V: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Volume(0.322257357278346 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Geometric surface area
	IsFixed: False
	Value: 3.28741697683031 [dm²]
	Formula: PI*(r1+r2)*L
		r2: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Distal radius(0.1960550545 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Length(2.6686823413 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Proximal radius(0.1960550545 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Intestinal transit rate (absolute)
	IsFixed: False
	Value: 0.00160702846666267 [1/min]
	Formula: LuminalVelocity/LITT_fact
		LuminalVelocity: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Intestinal transit rate(4.0741 [1/min])
		LITT_fact: PBPK_model_human_Ab|Organism|LargeIntestine|Large intestinal transit time factor(2535.176)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Length
	IsFixed: False
	Value: 2.6686823413 [dm]
	Formula: L_p0 + Height*L_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		L_p0: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|L_p0(0.5337898629 [dm])
		L_p1: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|L_p1(0.121300709)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Liquid
	IsFixed: False
	Value: 0.00193383417529163 [l]
	Formula: V*SteadyStateFillLevel
		SteadyStateFillLevel: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Fractional steady state fill level(0.0060009)
		V: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Volume(0.322257357278346 [l])
	RHS_Formula: OralApplicationsEnabled ? LT_coldesc - LT_colsigm + Inflow*FillLevelFlag - Outflow*Liquid : 0
		Outflow: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Absorption of liquid(0.0218151710161709 [1/min])
		FillLevelFlag: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|FillLevelFlag(1)
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Liquid(0.00193383417529163 [l])
		LT_colsigm: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Liquid transfer rate(3.10772656949877E-06 [l/min])
		Inflow: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Secretion of liquid(4.22124912298906E-05 [l/min])
		LT_coldesc: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Liquid transfer rate(3.08215859051085E-06 [l/min])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Liquid transfer rate
	IsFixed: False
	Value: 3.10772656949877E-06 [l/min]
	Formula: w*Liquid*FillLevelFlagNext
		w: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Intestinal transit rate (absolute)(0.00160702846666267 [1/min])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Liquid(0.00193383417529163 [l])
		FillLevelFlagNext: PBPK_model_human_Ab|Organism|Lumen|Rectum|FillLevelFlag(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Proximal radius
	IsFixed: False
	Value: 0.1960550545 [dm]
	Formula: r1_p0 + Height*r1_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r1_p0: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|r1_p0(0.0384322177 [dm])
		r1_p1: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|r1_p1(0.008955843)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Secretion of liquid
	IsFixed: False
	Value: 4.22124912298906E-05 [l/min]
	Formula: 0.00013099*V
		V: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Volume(0.322257357278346 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Absorption of liquid
	IsFixed: False
	Value: 0.0218151710161709 [1/min]
	Formula: (k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)
		alpha: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Fractional steady state fill level(0.0060009)
		k: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Intestinal transit rate (absolute)(0.00160702846666267 [1/min])
		inflow: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Secretion of liquid(4.22124912298906E-05 [l/min])
		V: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Volume(0.322257357278346 [l])
		alpha_p: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Fractional steady state fill level(0.0060009)
		k_p: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Intestinal transit rate (absolute)(0.00197224965840636 [1/min])
		V_p: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Volume(0.260421419682279 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Volume
	IsFixed: False
	Value: 0.322257357278346 [l]
	Formula: PI*(r1*r1+r1*r2+r2*r2)/3*L
		r2: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Distal radius(0.1960550545 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Length(2.6686823413 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Proximal radius(0.1960550545 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Thickness of gut wall
	IsFixed: False
	Value: 0.01634327810061 [dm]
	Formula: Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		Thickness_p1: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Thickness_p1(-0.00536 [dm])
		Thickness_p2: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Thickness_p2(0.0274432593 [dm])
		Thickness_p3: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Thickness_p3(-0.0889014 [1/dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Volume (gut wall)
	IsFixed: False
	Value: 0.0556850651636279 [l]
	Formula: V_Intestine * 0.135
		V_Intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Volume of protein container
	IsFixed: False
	Value: 0.322257357278346 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Volume(0.322257357278346 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Thickness_p2
	IsFixed: False
	Value: 0.0274432593 [dm]
	Formula: 0.0274432593

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|pH
	IsFixed: False
	Value: 6.6
	Formula: 6.6

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Fractional steady state fill level
	IsFixed: False
	Value: 0.0060009
	Formula: 0.0060009

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Intestinal transit rate
	IsFixed: False
	Value: 4.0741 [1/min]
	Formula: 4.0741

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|L_p0
	IsFixed: False
	Value: 0.5337898629 [dm]
	Formula: 0.5337898629

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Microvilli factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Thickness_p3
	IsFixed: False
	Value: -0.0889014 [1/dm]
	Formula: -0.0889014

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|r1_p0
	IsFixed: False
	Value: 0.0384322177 [dm]
	Formula: 0.0384322177

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|r1_p1
	IsFixed: False
	Value: 0.008955843
	Formula: 0.008955843

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|r2_p0
	IsFixed: False
	Value: 0.0384322177 [dm]
	Formula: 0.0384322177

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|r2_p1
	IsFixed: False
	Value: 0.008955843
	Formula: 0.008955843

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Thickness_p1
	IsFixed: False
	Value: -0.00536 [dm]
	Formula: -0.00536

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|L_p1
	IsFixed: False
	Value: 0.121300709
	Formula: 0.121300709

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Effective surface area enhancement factor
	IsFixed: False
	Value: 2.5
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Volume(0.322257357278346 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|Oral mass absorbed segment
	IsFixed: False
	Value: 0 [µmol]
	Formula: 0
	RHS_Formula: PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)
		ActiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|CDA1|Sum of active process rates(0 [µmol/min])
		ActiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|Sum of active process rates(0 [µmol/min])
		PassiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|CDA1|Sum of passive process rates(0 [µmol/min])
		PassiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|Sum of passive process rates(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|pH(6.6)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|pH(6.6)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|pH(6.6)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|Solubility
	IsFixed: False
	Value: 0.000999 [kg/l]
	Formula: Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor
		Solubility_pKa_pH_Factor: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|Solubility_pKa_pH_Factor(1)
		Solubility: PBPK_model_human_Ab|CDA1|Solubility at reference pH(0.000999 [kg/l])
		Solubility_pKa_REFpH_Factor: PBPK_model_human_Ab|CDA1|Solubility_pKa_pH_Factor(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|Solubility_pKa_pH_Factor
	IsFixed: False
	Value: 1
	Formula: K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)
		K1: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_K8(0)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		base: PBPK_model_human_Ab|CDA1|Solubility gain per charge(1000)

Parameter: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Liquid
	IsFixed: False
	Value: 0.000525578833597355 [l]
	Formula: V*SteadyStateFillLevel
		SteadyStateFillLevel: PBPK_model_human_Ab|Organism|Lumen|Rectum|Fractional steady state fill level(0.0060009)
		V: PBPK_model_human_Ab|Organism|Lumen|Rectum|Volume(0.0875833347660109 [l])
	RHS_Formula: OralApplicationsEnabled ? LT_colsigm - LT_rect + Inflow*FillLevelFlag : 0
		FillLevelFlag: PBPK_model_human_Ab|Organism|Lumen|Rectum|FillLevelFlag(1)
		LT_rect: PBPK_model_human_Ab|Organism|Lumen|Rectum|Liquid transfer rate(6.54321989093972E-05 [l/min])
		Inflow: PBPK_model_human_Ab|Organism|Lumen|Rectum|Secretion of liquid(6.24004985207398E-05 [l/min])
		LT_colsigm: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Liquid transfer rate(3.10772656949877E-06 [l/min])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Absorption of liquid
	IsFixed: False
	Value: 0.000144652288070653 [1/min]
	Formula: (k_p*alpha_p*V_p+inflow-k*alpha*V)/(alpha*V)
		alpha: PBPK_model_human_Ab|Organism|Lumen|Rectum|Fractional steady state fill level(0.0060009)
		k: PBPK_model_human_Ab|Organism|Lumen|Rectum|Intestinal transit rate (absolute)(0.12449549853738 [1/min])
		inflow: PBPK_model_human_Ab|Organism|Lumen|Rectum|Secretion of liquid(6.24004985207398E-05 [l/min])
		V: PBPK_model_human_Ab|Organism|Lumen|Rectum|Volume(0.0875833347660109 [l])
		alpha_p: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Fractional steady state fill level(0.0060009)
		k_p: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Intestinal transit rate (absolute)(0.00160702846666267 [1/min])
		V_p: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Volume(0.322257357278346 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Distal radius
	IsFixed: False
	Value: 0.1225344113 [dm]
	Formula: r2_p0 + Height*r2_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r2_p0: PBPK_model_human_Ab|Organism|Lumen|Rectum|r2_p0(0.0240201361 [dm])
		r2_p1: PBPK_model_human_Ab|Organism|Lumen|Rectum|r2_p1(0.005597402)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Effective surface area
	IsFixed: False
	Value: 3.84643425864822 [dm²]
	Formula: Ageom*AeffFactor*AeffVariabilityFactor
		AeffFactor: PBPK_model_human_Ab|Organism|Lumen|Rectum|Effective surface area enhancement factor(3.56)
		Ageom: PBPK_model_human_Ab|Organism|Lumen|Rectum|Geometric surface area(1.08045905859824 [dm²])
		AeffVariabilityFactor: PBPK_model_human_Ab|Organism|Lumen|Effective surface area variability factor(1.00000000260982)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|FillLevelFlag
	IsFixed: False
	Value: 1
	Formula: (FillLevel<0.9?1:1/(1+exp((FillLevel-1)/0.01)))
		FillLevel: PBPK_model_human_Ab|Organism|Lumen|Rectum|Fraction of geometric volume filled with liquid(0.0060009)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Fraction of geometric volume filled with liquid
	IsFixed: False
	Value: 0.0060009
	Formula: Liquid/V
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Rectum|Liquid(0.000525578833597355 [l])
		V: PBPK_model_human_Ab|Organism|Lumen|Rectum|Volume(0.0875833347660109 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Geometric surface area
	IsFixed: False
	Value: 1.08045905859824 [dm²]
	Formula: PI*(r1+r2)*L
		r2: PBPK_model_human_Ab|Organism|Lumen|Rectum|Distal radius(0.1225344113 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|Rectum|Length(1.0795108969 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|Rectum|Proximal radius(0.1960550545 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Length
	IsFixed: False
	Value: 1.0795108969 [dm]
	Formula: L_p0 + Height*L_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		L_p0: PBPK_model_human_Ab|Organism|Lumen|Rectum|L_p0(0.1569046761 [dm])
		L_p1: PBPK_model_human_Ab|Organism|Lumen|Rectum|L_p1(0.052420808)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Liquid transfer rate
	IsFixed: False
	Value: 6.54321989093972E-05 [l/min]
	Formula: w*Liquid
		w: PBPK_model_human_Ab|Organism|Lumen|Rectum|Intestinal transit rate (absolute)(0.12449549853738 [1/min])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Rectum|Liquid(0.000525578833597355 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Proximal radius
	IsFixed: False
	Value: 0.1960550545 [dm]
	Formula: r1_p0 + Height*r1_p1
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		r1_p0: PBPK_model_human_Ab|Organism|Lumen|Rectum|r1_p0(0.0384322177 [dm])
		r1_p1: PBPK_model_human_Ab|Organism|Lumen|Rectum|r1_p1(0.008955843)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Secretion of liquid
	IsFixed: False
	Value: 6.24004985207398E-05 [l/min]
	Formula: 0.00071247*V
		V: PBPK_model_human_Ab|Organism|Lumen|Rectum|Volume(0.0875833347660109 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Thickness of gut wall
	IsFixed: False
	Value: 0.0202494798532162 [dm]
	Formula: Thickness_p1 + Thickness_p2*(1-exp(Thickness_p3*Height))
		Height: PBPK_model_human_Ab|Organism|Height(17.6 [dm])
		Thickness_p1: PBPK_model_human_Ab|Organism|Lumen|Rectum|Thickness_p1(-0.00665 [dm])
		Thickness_p2: PBPK_model_human_Ab|Organism|Lumen|Rectum|Thickness_p2(0.0324721331 [dm])
		Thickness_p3: PBPK_model_human_Ab|Organism|Lumen|Rectum|Thickness_p3(-0.10014267 [1/dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Volume
	IsFixed: False
	Value: 0.0875833347660109 [l]
	Formula: PI*(r1*r1+r1*r2+r2*r2)/3*L
		r2: PBPK_model_human_Ab|Organism|Lumen|Rectum|Distal radius(0.1225344113 [dm])
		L: PBPK_model_human_Ab|Organism|Lumen|Rectum|Length(1.0795108969 [dm])
		r1: PBPK_model_human_Ab|Organism|Lumen|Rectum|Proximal radius(0.1960550545 [dm])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Volume (gut wall)
	IsFixed: False
	Value: 0.0226865080296262 [l]
	Formula: V_Intestine * 0.055
		V_Intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Volume of protein container
	IsFixed: False
	Value: 0.0875833347660109 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lumen|Rectum|Volume(0.0875833347660109 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Intestinal transit rate (absolute)
	IsFixed: False
	Value: 0.12449549853738 [1/min]
	Formula: LuminalVelocity/LITT_fact
		LuminalVelocity: PBPK_model_human_Ab|Organism|Lumen|Rectum|Intestinal transit rate(315.618 [1/min])
		LITT_fact: PBPK_model_human_Ab|Organism|LargeIntestine|Large intestinal transit time factor(2535.176)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|r2_p0
	IsFixed: False
	Value: 0.0240201361 [dm]
	Formula: 0.0240201361

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|r1_p1
	IsFixed: False
	Value: 0.008955843
	Formula: 0.008955843

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|r1_p0
	IsFixed: False
	Value: 0.0384322177 [dm]
	Formula: 0.0384322177

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|pH
	IsFixed: False
	Value: 6.6
	Formula: 6.6

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Microvilli factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|L_p1
	IsFixed: False
	Value: 0.052420808
	Formula: 0.052420808

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|L_p0
	IsFixed: False
	Value: 0.1569046761 [dm]
	Formula: 0.1569046761

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Intestinal transit rate
	IsFixed: False
	Value: 315.618 [1/min]
	Formula: 315.618

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Fractional steady state fill level
	IsFixed: False
	Value: 0.0060009
	Formula: 0.0060009

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Thickness_p1
	IsFixed: False
	Value: -0.00665 [dm]
	Formula: -0.00665

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|r2_p1
	IsFixed: False
	Value: 0.005597402
	Formula: 0.005597402

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Thickness_p2
	IsFixed: False
	Value: 0.0324721331 [dm]
	Formula: 0.0324721331

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Thickness_p3
	IsFixed: False
	Value: -0.10014267 [1/dm]
	Formula: -0.10014267

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|Effective surface area enhancement factor
	IsFixed: False
	Value: 3.56
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lumen|Rectum|Volume(0.0875833347660109 [l])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|Oral mass absorbed segment
	IsFixed: False
	Value: 0 [µmol]
	Formula: 0
	RHS_Formula: PassiveRates_para+PassiveRates_trans-(ActiveRates_para+ActiveRates_trans)
		ActiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_pls|CDA1|Sum of active process rates(0 [µmol/min])
		ActiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|Sum of active process rates(0 [µmol/min])
		PassiveRates_para: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_pls|CDA1|Sum of passive process rates(0 [µmol/min])
		PassiveRates_trans: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|Sum of passive process rates(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|Rectum|pH(6.6)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|Rectum|pH(6.6)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|Solubility
	IsFixed: False
	Value: 0.000999 [kg/l]
	Formula: Solubility * Solubility_pKa_REFpH_Factor / Solubility_pKa_pH_Factor
		Solubility_pKa_pH_Factor: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|Solubility_pKa_pH_Factor(1)
		Solubility: PBPK_model_human_Ab|CDA1|Solubility at reference pH(0.000999 [kg/l])
		Solubility_pKa_REFpH_Factor: PBPK_model_human_Ab|CDA1|Solubility_pKa_pH_Factor(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|Solubility_pKa_pH_Factor
	IsFixed: False
	Value: 1
	Formula: K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)
		K1: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_K8(0)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		base: PBPK_model_human_Ab|CDA1|Solubility gain per charge(1000)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|Lumen|Rectum|pH(6.6)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Feces|Liquid
	IsFixed: False
	Value: 0 [l]
	Formula: 0
	RHS_Formula: OralApplicationsEnabled ? LT_rec : 0
		LT_rec: PBPK_model_human_Ab|Organism|Lumen|Rectum|Liquid transfer rate(6.54321989093972E-05 [l/min])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)

Parameter: PBPK_model_human_Ab|Organism|Lumen|Feces|Volume
	IsFixed: False
	Value: 1 [l]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lumen|Feces|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lumen|Feces|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lumen|Feces|Volume(1 [l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Stomach|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|Stomach|Weight (tissue)
	IsFixed: False
	Value: 0.168544443550188 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|Stomach|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|Stomach|Volume(0.168544443550188 [l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Stomach|Lymph flow rate
	IsFixed: False
	Value: 7.03591004386913E-05 [l/min]
	Formula: f_lymph*Q*(1-HCT)
		Q: PBPK_model_human_Ab|Organism|Stomach|Blood flow rate(0.0650750096547275 [l/min])
		f_lymph: PBPK_model_human_Ab|Organism|Stomach|Lymph flow proportionality factor(0.00204)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Stomach|Volume (endothelium)
	IsFixed: False
	Value: 0.000153712532517771 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)(51.2375108392571 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Fluid recirculation flow rate
	IsFixed: False
	Value: 5.57959880187978E-06 [l/min]
	Formula: f_Jiso * (1-alpha_l) * Q_lymph * (V/V_mouse)^(exp_Jiso_scale - 1)
		alpha_l: PBPK_model_human_Ab|Organism|Stomach|Flow fraction via large pores(0.05)
		f_Jiso: PBPK_model_human_Ab|Organism|Stomach|Fluid recirculation flow proportionality factor(0.96)
		Q_lymph: PBPK_model_human_Ab|Organism|Stomach|Lymph flow rate(7.03591004386913E-05 [l/min])
		V_mouse: PBPK_model_human_Ab|Organism|Stomach|Organ volume mouse(0.00011 [l])
		V: PBPK_model_human_Ab|Organism|Stomach|Volume(0.168544443550188 [l])
		exp_Jiso_scale: PBPK_model_human_Ab|Organism|Scaling exponent for fluid recirculation flow rate(0.667)

Parameter: PBPK_model_human_Ab|Organism|Stomach|Fraction intracellular
	IsFixed: False
	Value: 0.868
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|Stomach|Fraction interstitial(0.1)
		f_vas: PBPK_model_human_Ab|Organism|Stomach|Fraction vascular(0.032)

Parameter: PBPK_model_human_Ab|Organism|Stomach|Blood flow rate
	IsFixed: False
	Value: 0.0650750096547275 [l/min]
	Formula: Qspec * Weight
		Qspec: PBPK_model_human_Ab|Organism|Stomach|Specific blood flow rate(0.3861 [l/min/kg organ])
		Weight: PBPK_model_human_Ab|Organism|Stomach|Weight (tissue)(0.168544443550188 [kg])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Lymph flow proportionality factor
	IsFixed: False
	Value: 0.00204
	Formula: 0.00204

Parameter: PBPK_model_human_Ab|Organism|Stomach|Organ volume mouse
	IsFixed: False
	Value: 0.00011 [l]
	Formula: 0.00011

Parameter: PBPK_model_human_Ab|Organism|Stomach|Fluid recirculation flow proportionality factor
	IsFixed: False
	Value: 0.96
	Formula: 0.96

Parameter: PBPK_model_human_Ab|Organism|Stomach|Allometric scale factor
	IsFixed: False
	Value: 0.75
	Formula: 0.75

Parameter: PBPK_model_human_Ab|Organism|Stomach|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Stomach|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Stomach|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|Stomach|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|Stomach|Hydraulic conductivity
	IsFixed: False
	Value: 3.97222222222222E-11 [l/min/(kg*dm/min²)]
	Formula: 3.97222222222222E-11

Parameter: PBPK_model_human_Ab|Organism|Stomach|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|Stomach|Vf (lipid)
	IsFixed: False
	Value: 0.062
	Formula: 0.062

Parameter: PBPK_model_human_Ab|Organism|Stomach|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0487
	Formula: 0.0487

Parameter: PBPK_model_human_Ab|Organism|Stomach|Fraction vascular
	IsFixed: False
	Value: 0.032
	Formula: 0.032

Parameter: PBPK_model_human_Ab|Organism|Stomach|Vf (protein)
	IsFixed: False
	Value: 0.133
	Formula: 0.133

Parameter: PBPK_model_human_Ab|Organism|Stomach|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0163
	Formula: 0.0163

Parameter: PBPK_model_human_Ab|Organism|Stomach|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.158
	Formula: 0.158

Parameter: PBPK_model_human_Ab|Organism|Stomach|Vf (water)-PT
	IsFixed: False
	Value: 0.718
	Formula: 0.718

Parameter: PBPK_model_human_Ab|Organism|Stomach|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.141
	Formula: 0.141

Parameter: PBPK_model_human_Ab|Organism|Stomach|Vf (water)
	IsFixed: False
	Value: 0.792
	Formula: 0.792

Parameter: PBPK_model_human_Ab|Organism|Stomach|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|Stomach|Fraction interstitial
	IsFixed: False
	Value: 0.1
	Formula: 0.1

Parameter: PBPK_model_human_Ab|Organism|Stomach|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0483
	Formula: 0.0483

Parameter: PBPK_model_human_Ab|Organism|Stomach|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0375
	Formula: 0.0375

Parameter: PBPK_model_human_Ab|Organism|Stomach|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0124
	Formula: 0.0124

Parameter: PBPK_model_human_Ab|Organism|Stomach|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0182
	Formula: 0.0182

Parameter: PBPK_model_human_Ab|Organism|Stomach|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.282
	Formula: 0.282

Parameter: PBPK_model_human_Ab|Organism|Stomach|Vf (protein)-WS
	IsFixed: False
	Value: 0.15
	Formula: 0.15

Parameter: PBPK_model_human_Ab|Organism|Stomach|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.456
	Formula: 0.456

Parameter: PBPK_model_human_Ab|Organism|Stomach|Vf (water)-WS
	IsFixed: False
	Value: 0.78
	Formula: 0.78

Parameter: PBPK_model_human_Ab|Organism|Stomach|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0035
	Formula: 0.0035

Parameter: PBPK_model_human_Ab|Organism|Stomach|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.41
	Formula: 2.41

Parameter: PBPK_model_human_Ab|Organism|Stomach|Volume
	IsFixed: False
	Value: 0.168544443550188 [l]
	Percentile: 0.501069890510121

Parameter: PBPK_model_human_Ab|Organism|Stomach|Specific blood flow rate
	IsFixed: False
	Value: 0.3861 [l/min/kg organ]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Stomach|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.00285851376261118 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Stomach|Plasma|Volume(0.00285851376261118 [l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Plasma|Volume
	IsFixed: False
	Value: 0.00285851376261118 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|Stomach|Fraction vascular(0.032)
		V_org: PBPK_model_human_Ab|Organism|Stomach|Volume(0.168544443550188 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Stomach|Plasma|Volume(0.00285851376261118 [l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Stomach|Plasma|Volume(0.00285851376261118 [l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.00253490843099482 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Stomach|BloodCells|Volume(0.00253490843099482 [l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|BloodCells|Volume
	IsFixed: False
	Value: 0.00253490843099482 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|Stomach|Fraction vascular(0.032)
		V: PBPK_model_human_Ab|Organism|Stomach|Volume(0.168544443550188 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Stomach|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Stomach|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Stomach|BloodCells|Volume(0.00253490843099482 [l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|Stomach|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.0168544443550188 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Stomach|Interstitial|Volume(0.0168544443550188 [l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Interstitial|Volume
	IsFixed: False
	Value: 0.0168544443550188 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|Stomach|Fraction interstitial(0.1)
		V: PBPK_model_human_Ab|Organism|Stomach|Volume(0.168544443550188 [l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Stomach|Interstitial|Volume(0.0168544443550188 [l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Stomach|Interstitial|Volume(0.0168544443550188 [l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.168544443550188 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Stomach|Volume(0.168544443550188 [l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Intracellular|Volume
	IsFixed: False
	Value: 0.146296577001563 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|Stomach|Fraction intracellular(0.868)
		V: PBPK_model_human_Ab|Organism|Stomach|Volume(0.168544443550188 [l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Intracellular|pH
	IsFixed: False
	Value: 7.4
	Formula: 7.4

Parameter: PBPK_model_human_Ab|Organism|Stomach|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Stomach|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Stomach|Intracellular|Volume(0.146296577001563 [l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.22908131578533
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|Partition coefficient (intracellular/water)(1.22908131578533)

Parameter: PBPK_model_human_Ab|Organism|Stomach|Endosome|Volume of protein container
	IsFixed: False
	Value: 3.07425065035542E-05 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Stomach|Endosome|Volume(3.07425065035542E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Endosome|Volume
	IsFixed: False
	Value: 3.07425065035542E-05 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|Stomach|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)(51.2375108392571 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Stomach|Endosome|Volume(3.07425065035542E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Stomach|Endosome|Volume(3.07425065035542E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Weight (tissue)
	IsFixed: False
	Value: 0.724467834480575 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|SmallIntestine|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Small intestinal transit time factor
	IsFixed: False
	Value: 71.3320001979601
	Formula: P1*SITT+P2
		SITT: PBPK_model_human_Ab|Organism|SmallIntestine|Small intestinal transit time(126.000000328837 [min])
		P2: PBPK_model_human_Ab|Organism|SmallIntestine|Small intestinal transit time factor intercept(-4.52)
		P1: PBPK_model_human_Ab|Organism|SmallIntestine|Small intestinal transit time factor slope(0.602 [1/min])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow rate (incl. mucosa)
	IsFixed: False
	Value: 0.000672104223100808 [l/min]
	Formula: f_lymph*Q*(1-HCT)
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Blood flow rate(0.650318551621488 [l/min])
		f_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow proportionality factor(0.00195)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Volume (endothelium)
	IsFixed: False
	Value: 0.000397618085424854 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)(132.539361808285 [dm²])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow rate
	IsFixed: False
	Value: 0.000539296428616088 [l/min]
	Formula: Q_lymph_incl_Mucosa-Q_lymph_duo-Q_lymph_uje-Q_lymph_lje-Q_lymph_uil-Q_lymph_lil
		Q_lymph_incl_Mucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow rate (incl. mucosa)(0.000672104223100808 [l/min])
		Q_lymph_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Lymph flow rate(1.52029975265403E-05 [l/min])
		Q_lymph_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Lymph flow rate(1.36302736444844E-05 [l/min])
		Q_lymph_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Lymph flow rate(3.21534660331426E-05 [l/min])
		Q_lymph_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Lymph flow rate(2.8309029877006E-05 [l/min])
		Q_lymph_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Lymph flow rate(4.35120274035463E-05 [l/min])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Fluid recirculation flow rate (incl. mucosa)
	IsFixed: False
	Value: 1.14629640224353E-05 [l/min]
	Formula: f_Jiso * (1-alpha_l) * Q_lymph * (V/V_mouse)^(exp_Jiso_scale - 1)
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Flow fraction via large pores(0.05)
		f_Jiso: PBPK_model_human_Ab|Organism|SmallIntestine|Fluid recirculation flow proportionality factor(0.179)
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow rate(0.000539296428616088 [l/min])
		V_mouse: PBPK_model_human_Ab|Organism|SmallIntestine|Organ volume mouse(0.001406 [l])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		exp_Jiso_scale: PBPK_model_human_Ab|Organism|Scaling exponent for fluid recirculation flow rate(0.667)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Fluid recirculation flow rate
	IsFixed: False
	Value: 9.19788233160212E-06 [l/min]
	Formula: J_iso_incl_Mucosa-J_iso_duo-J_iso_uje-J_iso_lje-J_iso_uil-J_iso_lil
		J_iso_incl_Mucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Fluid recirculation flow rate (incl. mucosa)(1.14629640224353E-05 [l/min])
		J_iso_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fluid recirculation flow rate(2.59292246187488E-07 [l/min])
		J_iso_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fluid recirculation flow rate(2.32468910374989E-07 [l/min])
		J_iso_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fluid recirculation flow rate(5.48388198833307E-07 [l/min])
		J_iso_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fluid recirculation flow rate(4.82820044624977E-07 [l/min])
		J_iso_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fluid recirculation flow rate(7.42112290812464E-07 [l/min])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction intracellular
	IsFixed: False
	Value: 0.882
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction interstitial(0.094)
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction vascular(0.024)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Blood flow rate
	IsFixed: False
	Value: 0.650318551621488 [l/min]
	Formula: Qspec * Weight
		Qspec: PBPK_model_human_Ab|Organism|SmallIntestine|Specific blood flow rate(0.89765 [l/min/kg organ])
		Weight: PBPK_model_human_Ab|Organism|SmallIntestine|Weight (tissue)(0.724467834480575 [kg])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Volume (mucosa)
	IsFixed: False
	Value: 0.143154844093362 [l]
	Formula: V_duo+V_uje+V_lje+V_uil+V_lil
		V_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Volume(0.0163874624159506 [l])
		V_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Volume(0.0146922076832661 [l])
		V_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Volume(0.0346585412015507 [l])
		V_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Volume(0.0305145851883218 [l])
		V_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Volume(0.0469020476042724 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow proportionality factor
	IsFixed: False
	Value: 0.00195
	Formula: 0.00195

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Organ volume mouse
	IsFixed: False
	Value: 0.001406 [l]
	Formula: 0.001406

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Fluid recirculation flow proportionality factor
	IsFixed: False
	Value: 0.179
	Formula: 0.179

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Allometric scale factor
	IsFixed: False
	Value: 0.75
	Formula: 0.75

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Small intestinal transit time factor intercept
	IsFixed: False
	Value: -4.52
	Formula: -4.52

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa blood flow fraction
	IsFixed: False
	Value: 0.75
	Formula: 0.75

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Small intestinal transit time factor slope
	IsFixed: False
	Value: 0.602 [1/min]
	Formula: 0.602

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Hydraulic conductivity
	IsFixed: False
	Value: 1.53888888888889E-10 [l/min/(kg*dm/min²)]
	Formula: 1.53888888888889E-10

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0487
	Formula: 0.0487

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (lipid)
	IsFixed: False
	Value: 0.062
	Formula: 0.062

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction vascular
	IsFixed: False
	Value: 0.024
	Formula: 0.024

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0163
	Formula: 0.0163

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (protein)
	IsFixed: False
	Value: 0.133
	Formula: 0.133

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (water)
	IsFixed: False
	Value: 0.792
	Formula: 0.792

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.158
	Formula: 0.158

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.141
	Formula: 0.141

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (water)-PT
	IsFixed: False
	Value: 0.718
	Formula: 0.718

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction interstitial
	IsFixed: False
	Value: 0.094
	Formula: 0.094

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0375
	Formula: 0.0375

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0483
	Formula: 0.0483

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0182
	Formula: 0.0182

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0124
	Formula: 0.0124

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.282
	Formula: 0.282

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (protein)-WS
	IsFixed: False
	Value: 0.15
	Formula: 0.15

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.456
	Formula: 0.456

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (water)-WS
	IsFixed: False
	Value: 0.78
	Formula: 0.78

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0035
	Formula: 0.0035

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.41
	Formula: 2.41

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Small intestinal transit time
	IsFixed: False
	Value: 126.000000328837 [min]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Volume
	IsFixed: False
	Value: 0.724467834480575 [l]
	Percentile: 0.501743832222423

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Specific blood flow rate
	IsFixed: False
	Value: 0.89765 [l/min/kg organ]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.00739430123772535 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|Volume(0.00739430123772535 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|Volume
	IsFixed: False
	Value: 0.00739430123772535 [l]
	Formula: f_vas*(1-HCT)*(V-V_Mucosa)
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction vascular(0.024)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_Mucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Volume (mucosa)(0.143154844093362 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|Volume(0.00739430123772535 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|Volume(0.00739430123772535 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.00655721053156776 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|Volume(0.00655721053156776 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|Volume
	IsFixed: False
	Value: 0.00655721053156776 [l]
	Formula: f_vas*HCT*(V-V_Mucosa)
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction vascular(0.024)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_Mucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Volume (mucosa)(0.143154844093362 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|Volume(0.00655721053156776 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.054643421096398 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|Volume(0.054643421096398 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|Volume
	IsFixed: False
	Value: 0.054643421096398 [l]
	Formula: f_int*(V-V_Mucosa)
		f_int: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction interstitial(0.094)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_Mucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Volume (mucosa)(0.143154844093362 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|Volume(0.054643421096398 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|Volume(0.054643421096398 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.581312990387213 [l]
	Formula: Volume-V_Mucosa
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_Mucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Volume (mucosa)(0.143154844093362 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|Volume
	IsFixed: False
	Value: 0.512718057521522 [l]
	Formula: f_cell*(V-V_Mucosa)
		f_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction intracellular(0.882)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_Mucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Volume (mucosa)(0.143154844093362 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|pH
	IsFixed: False
	Value: 7.4
	Formula: 7.4

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|Volume(0.512718057521522 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.22908131578533
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|Partition coefficient (intracellular/water)(1.22908131578533)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|Volume of protein container
	IsFixed: False
	Value: 7.95236170849708E-05 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|Volume(7.95236170849708E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|Volume
	IsFixed: False
	Value: 7.95236170849708E-05 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)(132.539361808285 [dm²])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|Volume(7.95236170849708E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|Volume(7.95236170849708E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Weight (tissue)
	IsFixed: False
	Value: 0.0163874624159506 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Volume(0.0163874624159506 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Volume
	IsFixed: False
	Value: 0.0163874624159506 [l]
	Formula: V_GutWall*fractionMucosa
		fractionMucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction mucosa(0.26)
		V_GutWall: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Volume (gut wall)(0.06302870159981 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fluid recirculation flow rate
	IsFixed: False
	Value: 2.59292246187488E-07 [l/min]
	Formula: J_iso_intestine * V_seg / V_intestine
		J_iso_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Fluid recirculation flow rate (incl. mucosa)(1.14629640224353E-05 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_seg: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Volume(0.0163874624159506 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Lymph flow rate
	IsFixed: False
	Value: 1.52029975265403E-05 [l/min]
	Formula: Q_lymph_intestine * V_seg / V_intestine
		Q_lymph_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow rate (incl. mucosa)(0.000672104223100808 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_seg: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Volume(0.0163874624159506 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Volume (endothelium)
	IsFixed: False
	Value: 6.0715548251097E-05 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)(20.238516083699 [dm²])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Blood flow rate
	IsFixed: False
	Value: 0.0453597189755988 [l/min]
	Formula: Q * fractQ * regionalFractQ
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Blood flow rate(0.650318551621488 [l/min])
		regionalFractQ: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction of regional blood flow rate(0.093)
		fractQ: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa blood flow fraction(0.75)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction intracellular
	IsFixed: False
	Value: 0.45
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction interstitial(0.42)
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction vascular(0.13)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction mucosa
	IsFixed: False
	Value: 0.26
	Formula: 0.26

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction of regional blood flow rate
	IsFixed: False
	Value: 0.093
	Formula: 0.093

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Hydraulic conductivity
	IsFixed: False
	Value: 1.53888888888889E-10 [l/min/(kg*dm/min²)]
	Formula: 1.53888888888889E-10

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0487
	Formula: 0.0487

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (lipid)
	IsFixed: False
	Value: 0.06
	Formula: 0.06

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction vascular
	IsFixed: False
	Value: 0.13
	Formula: 0.13

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (protein)
	IsFixed: False
	Value: 0.08
	Formula: 0.08

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0163
	Formula: 0.0163

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (water)-PT
	IsFixed: False
	Value: 0.718
	Formula: 0.718

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.141
	Formula: 0.141

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.158
	Formula: 0.158

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (water)
	IsFixed: False
	Value: 0.8
	Formula: 0.8

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction interstitial
	IsFixed: False
	Value: 0.42
	Formula: 0.42

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0483
	Formula: 0.0483

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0375
	Formula: 0.0375

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0124
	Formula: 0.0124

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0182
	Formula: 0.0182

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (protein)-WS
	IsFixed: False
	Value: 0.15
	Formula: 0.15

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.282
	Formula: 0.282

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (water)-WS
	IsFixed: False
	Value: 0.78
	Formula: 0.78

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.456
	Formula: 0.456

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0035
	Formula: 0.0035

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.41
	Formula: 2.41

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.001129096160459 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Volume(0.001129096160459 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Volume
	IsFixed: False
	Value: 0.001129096160459 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction vascular(0.13)
		V_org: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Volume(0.0163874624159506 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Volume(0.001129096160459 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Volume(0.001129096160459 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.00100127395361458 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|Volume(0.00100127395361458 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|Volume
	IsFixed: False
	Value: 0.00100127395361458 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction vascular(0.13)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Volume(0.0163874624159506 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|Volume(0.00100127395361458 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.00688273421469925 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume(0.00688273421469925 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume
	IsFixed: False
	Value: 0.00688273421469925 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction interstitial(0.42)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Volume(0.0163874624159506 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume(0.00688273421469925 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume(0.00688273421469925 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.0163874624159506 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Volume(0.0163874624159506 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Volume
	IsFixed: False
	Value: 0.00737435808717777 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction intracellular(0.45)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Volume(0.0163874624159506 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|pH
	IsFixed: False
	Value: 7.3
	Formula: 7.3

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Volume(0.00737435808717777 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume of protein container
	IsFixed: False
	Value: 1.21431096502194E-05 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume(1.21431096502194E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume
	IsFixed: False
	Value: 1.21431096502194E-05 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)(20.238516083699 [dm²])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume(1.21431096502194E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume(1.21431096502194E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Weight (tissue)
	IsFixed: False
	Value: 0.0469020476042724 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Volume(0.0469020476042724 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Volume
	IsFixed: False
	Value: 0.0469020476042724 [l]
	Formula: V_GutWall*fractionMucosa
		fractionMucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction mucosa(0.26)
		V_GutWall: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Volume (gut wall)(0.180392490785663 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Lymph flow rate
	IsFixed: False
	Value: 4.35120274035463E-05 [l/min]
	Formula: Q_lymph_intestine * V_seg / V_intestine
		Q_lymph_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow rate (incl. mucosa)(0.000672104223100808 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_seg: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Volume(0.0469020476042724 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Volume (endothelium)
	IsFixed: False
	Value: 0.000173772086373829 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)(57.9240287912764 [dm²])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fluid recirculation flow rate
	IsFixed: False
	Value: 7.42112290812464E-07 [l/min]
	Formula: J_iso_intestine * V_seg / V_intestine
		J_iso_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Fluid recirculation flow rate (incl. mucosa)(1.14629640224353E-05 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_seg: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Volume(0.0469020476042724 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Blood flow rate
	IsFixed: False
	Value: 0.106814822103829 [l/min]
	Formula: Q * fractQ * regionalFractQ
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Blood flow rate(0.650318551621488 [l/min])
		regionalFractQ: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction of regional blood flow rate(0.219)
		fractQ: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa blood flow fraction(0.75)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction intracellular
	IsFixed: False
	Value: 0.52
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction interstitial(0.35)
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction vascular(0.13)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction mucosa
	IsFixed: False
	Value: 0.26
	Formula: 0.26

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction of regional blood flow rate
	IsFixed: False
	Value: 0.219
	Formula: 0.219

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Hydraulic conductivity
	IsFixed: False
	Value: 1.53888888888889E-10 [l/min/(kg*dm/min²)]
	Formula: 1.53888888888889E-10

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0487
	Formula: 0.0487

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (lipid)
	IsFixed: False
	Value: 0.06
	Formula: 0.06

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction vascular
	IsFixed: False
	Value: 0.13
	Formula: 0.13

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0163
	Formula: 0.0163

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (protein)
	IsFixed: False
	Value: 0.08
	Formula: 0.08

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.158
	Formula: 0.158

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.141
	Formula: 0.141

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (water)
	IsFixed: False
	Value: 0.8
	Formula: 0.8

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (water)-PT
	IsFixed: False
	Value: 0.718
	Formula: 0.718

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction interstitial
	IsFixed: False
	Value: 0.35
	Formula: 0.35

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0375
	Formula: 0.0375

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0483
	Formula: 0.0483

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0124
	Formula: 0.0124

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0182
	Formula: 0.0182

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.282
	Formula: 0.282

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (protein)-WS
	IsFixed: False
	Value: 0.15
	Formula: 0.15

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.456
	Formula: 0.456

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (water)-WS
	IsFixed: False
	Value: 0.78
	Formula: 0.78

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.41
	Formula: 2.41

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0035
	Formula: 0.0035

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.00323155107993437 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Volume(0.00323155107993437 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Volume
	IsFixed: False
	Value: 0.00323155107993437 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction vascular(0.13)
		V_org: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Volume(0.0469020476042724 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Volume(0.00323155107993437 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Volume(0.00323155107993437 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.00286571510862104 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|Volume(0.00286571510862104 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|Volume
	IsFixed: False
	Value: 0.00286571510862104 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction vascular(0.13)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Volume(0.0469020476042724 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|Volume(0.00286571510862104 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.0164157166614953 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume(0.0164157166614953 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume
	IsFixed: False
	Value: 0.0164157166614953 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction interstitial(0.35)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Volume(0.0469020476042724 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume(0.0164157166614953 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume(0.0164157166614953 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.0469020476042724 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Volume(0.0469020476042724 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Volume
	IsFixed: False
	Value: 0.0243890647542217 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction intracellular(0.52)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Volume(0.0469020476042724 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|pH
	IsFixed: False
	Value: 7.3
	Formula: 7.3

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Volume(0.0243890647542217 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume of protein container
	IsFixed: False
	Value: 3.47544172747659E-05 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume(3.47544172747659E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume
	IsFixed: False
	Value: 3.47544172747659E-05 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)(57.9240287912764 [dm²])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume(3.47544172747659E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume(3.47544172747659E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Weight (tissue)
	IsFixed: False
	Value: 0.0346585412015507 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Volume(0.0346585412015507 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Volume
	IsFixed: False
	Value: 0.0346585412015507 [l]
	Formula: V_GutWall*fractionMucosa
		fractionMucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction mucosa(0.26)
		V_GutWall: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Volume (gut wall)(0.133302081544426 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Volume (endothelium)
	IsFixed: False
	Value: 0.000128409895151745 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)(42.8032983839151 [dm²])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Lymph flow rate
	IsFixed: False
	Value: 3.21534660331426E-05 [l/min]
	Formula: Q_lymph_intestine * V_seg / V_intestine
		Q_lymph_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow rate (incl. mucosa)(0.000672104223100808 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_seg: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Volume(0.0346585412015507 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fluid recirculation flow rate
	IsFixed: False
	Value: 5.48388198833307E-07 [l/min]
	Formula: J_iso_intestine * V_seg / V_intestine
		J_iso_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Fluid recirculation flow rate (incl. mucosa)(1.14629640224353E-05 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_seg: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Volume(0.0346585412015507 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Blood flow rate
	IsFixed: False
	Value: 0.106814822103829 [l/min]
	Formula: Q * fractQ * regionalFractQ
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Blood flow rate(0.650318551621488 [l/min])
		regionalFractQ: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction of regional blood flow rate(0.219)
		fractQ: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa blood flow fraction(0.75)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction intracellular
	IsFixed: False
	Value: 0.55
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction interstitial(0.32)
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction vascular(0.13)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction of regional blood flow rate
	IsFixed: False
	Value: 0.219
	Formula: 0.219

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction mucosa
	IsFixed: False
	Value: 0.26
	Formula: 0.26

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Hydraulic conductivity
	IsFixed: False
	Value: 1.53888888888889E-10 [l/min/(kg*dm/min²)]
	Formula: 1.53888888888889E-10

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (lipid)
	IsFixed: False
	Value: 0.06
	Formula: 0.06

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0487
	Formula: 0.0487

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction vascular
	IsFixed: False
	Value: 0.13
	Formula: 0.13

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (protein)
	IsFixed: False
	Value: 0.08
	Formula: 0.08

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0163
	Formula: 0.0163

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (water)-PT
	IsFixed: False
	Value: 0.718
	Formula: 0.718

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (water)
	IsFixed: False
	Value: 0.8
	Formula: 0.8

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.141
	Formula: 0.141

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.158
	Formula: 0.158

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction interstitial
	IsFixed: False
	Value: 0.32
	Formula: 0.32

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0483
	Formula: 0.0483

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0375
	Formula: 0.0375

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0124
	Formula: 0.0124

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0182
	Formula: 0.0182

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (protein)-WS
	IsFixed: False
	Value: 0.15
	Formula: 0.15

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.282
	Formula: 0.282

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (water)-WS
	IsFixed: False
	Value: 0.78
	Formula: 0.78

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.456
	Formula: 0.456

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0035
	Formula: 0.0035

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.41
	Formula: 2.41

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.00238797348878684 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Volume(0.00238797348878684 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Volume
	IsFixed: False
	Value: 0.00238797348878684 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction vascular(0.13)
		V_org: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Volume(0.0346585412015507 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Volume(0.00238797348878684 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Volume(0.00238797348878684 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.00211763686741475 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|Volume(0.00211763686741475 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|Volume
	IsFixed: False
	Value: 0.00211763686741475 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction vascular(0.13)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Volume(0.0346585412015507 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|Volume(0.00211763686741475 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.0110907331844962 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume(0.0110907331844962 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume
	IsFixed: False
	Value: 0.0110907331844962 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction interstitial(0.32)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Volume(0.0346585412015507 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume(0.0110907331844962 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume(0.0110907331844962 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.0346585412015507 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Volume(0.0346585412015507 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Volume
	IsFixed: False
	Value: 0.0190621976608529 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction intracellular(0.55)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Volume(0.0346585412015507 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|pH
	IsFixed: False
	Value: 7.3
	Formula: 7.3

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Volume(0.0190621976608529 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume of protein container
	IsFixed: False
	Value: 2.56819790303491E-05 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume(2.56819790303491E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume
	IsFixed: False
	Value: 2.56819790303491E-05 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)(42.8032983839151 [dm²])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume(2.56819790303491E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume(2.56819790303491E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Weight (tissue)
	IsFixed: False
	Value: 0.0305145851883218 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Volume(0.0305145851883218 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Volume
	IsFixed: False
	Value: 0.0305145851883218 [l]
	Formula: V_GutWall*fractionMucosa
		fractionMucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction mucosa(0.13)
		V_GutWall: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Volume (gut wall)(0.234727578371706 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fluid recirculation flow rate
	IsFixed: False
	Value: 4.82820044624977E-07 [l/min]
	Formula: J_iso_intestine * V_seg / V_intestine
		J_iso_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Fluid recirculation flow rate (incl. mucosa)(1.14629640224353E-05 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_seg: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Volume(0.0305145851883218 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Lymph flow rate
	IsFixed: False
	Value: 2.8309029877006E-05 [l/min]
	Formula: Q_lymph_intestine * V_seg / V_intestine
		Q_lymph_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow rate (incl. mucosa)(0.000672104223100808 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_seg: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Volume(0.0305145851883218 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Volume (endothelium)
	IsFixed: False
	Value: 0.000113056538122732 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)(37.6855127075774 [dm²])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Blood flow rate
	IsFixed: False
	Value: 0.114374775266429 [l/min]
	Formula: Q * fractQ * regionalFractQ
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Blood flow rate(0.650318551621488 [l/min])
		regionalFractQ: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction of regional blood flow rate(0.2345)
		fractQ: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa blood flow fraction(0.75)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction intracellular
	IsFixed: False
	Value: 0.56
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction interstitial(0.31)
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction vascular(0.13)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction mucosa
	IsFixed: False
	Value: 0.13
	Formula: 0.13

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction of regional blood flow rate
	IsFixed: False
	Value: 0.2345
	Formula: 0.2345

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Hydraulic conductivity
	IsFixed: False
	Value: 1.53888888888889E-10 [l/min/(kg*dm/min²)]
	Formula: 1.53888888888889E-10

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (lipid)
	IsFixed: False
	Value: 0.06
	Formula: 0.06

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0487
	Formula: 0.0487

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction vascular
	IsFixed: False
	Value: 0.13
	Formula: 0.13

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (protein)
	IsFixed: False
	Value: 0.08
	Formula: 0.08

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0163
	Formula: 0.0163

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (water)
	IsFixed: False
	Value: 0.8
	Formula: 0.8

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (water)-PT
	IsFixed: False
	Value: 0.718
	Formula: 0.718

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.158
	Formula: 0.158

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.141
	Formula: 0.141

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction interstitial
	IsFixed: False
	Value: 0.31
	Formula: 0.31

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0483
	Formula: 0.0483

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0375
	Formula: 0.0375

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0124
	Formula: 0.0124

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0182
	Formula: 0.0182

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.282
	Formula: 0.282

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (protein)-WS
	IsFixed: False
	Value: 0.15
	Formula: 0.15

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.456
	Formula: 0.456

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (water)-WS
	IsFixed: False
	Value: 0.78
	Formula: 0.78

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0035
	Formula: 0.0035

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.41
	Formula: 2.41

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.00210245491947537 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Volume(0.00210245491947537 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Volume
	IsFixed: False
	Value: 0.00210245491947537 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction vascular(0.13)
		V_org: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Volume(0.0305145851883218 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Volume(0.00210245491947537 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Volume(0.00210245491947537 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.00186444115500646 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|Volume(0.00186444115500646 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|Volume
	IsFixed: False
	Value: 0.00186444115500646 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction vascular(0.13)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Volume(0.0305145851883218 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|Volume(0.00186444115500646 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.00945952140837976 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume(0.00945952140837976 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume
	IsFixed: False
	Value: 0.00945952140837976 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction interstitial(0.31)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Volume(0.0305145851883218 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume(0.00945952140837976 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume(0.00945952140837976 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.0305145851883218 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Volume(0.0305145851883218 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Volume
	IsFixed: False
	Value: 0.0170881677054602 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction intracellular(0.56)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Volume(0.0305145851883218 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|pH
	IsFixed: False
	Value: 7.3
	Formula: 7.3

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Volume(0.0170881677054602 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume of protein container
	IsFixed: False
	Value: 2.26113076245465E-05 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume(2.26113076245465E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume
	IsFixed: False
	Value: 2.26113076245465E-05 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)(37.6855127075774 [dm²])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume(2.26113076245465E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume(2.26113076245465E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Weight (tissue)
	IsFixed: False
	Value: 0.0146922076832661 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Volume(0.0146922076832661 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Volume
	IsFixed: False
	Value: 0.0146922076832661 [l]
	Formula: V_GutWall*fractionMucosa
		fractionMucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction mucosa(0.13)
		V_GutWall: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Volume (gut wall)(0.11301698217897 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fluid recirculation flow rate
	IsFixed: False
	Value: 2.32468910374989E-07 [l/min]
	Formula: J_iso_intestine * V_seg / V_intestine
		J_iso_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Fluid recirculation flow rate (incl. mucosa)(1.14629640224353E-05 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_seg: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Volume(0.0146922076832661 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Lymph flow rate
	IsFixed: False
	Value: 1.36302736444844E-05 [l/min]
	Formula: Q_lymph_intestine * V_seg / V_intestine
		Q_lymph_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow rate (incl. mucosa)(0.000672104223100808 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_seg: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Volume(0.0146922076832661 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Volume (endothelium)
	IsFixed: False
	Value: 5.44346294665008E-05 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)(18.1448764888336 [dm²])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Blood flow rate
	IsFixed: False
	Value: 0.114374775266429 [l/min]
	Formula: Q * fractQ * regionalFractQ
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Blood flow rate(0.650318551621488 [l/min])
		regionalFractQ: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction of regional blood flow rate(0.2345)
		fractQ: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa blood flow fraction(0.75)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction intracellular
	IsFixed: False
	Value: 0.55
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction interstitial(0.32)
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction vascular(0.13)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction mucosa
	IsFixed: False
	Value: 0.13
	Formula: 0.13

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction of regional blood flow rate
	IsFixed: False
	Value: 0.2345
	Formula: 0.2345

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Hydraulic conductivity
	IsFixed: False
	Value: 1.53888888888889E-10 [l/min/(kg*dm/min²)]
	Formula: 1.53888888888889E-10

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0487
	Formula: 0.0487

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (lipid)
	IsFixed: False
	Value: 0.06
	Formula: 0.06

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction vascular
	IsFixed: False
	Value: 0.13
	Formula: 0.13

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (protein)
	IsFixed: False
	Value: 0.08
	Formula: 0.08

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0163
	Formula: 0.0163

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.141
	Formula: 0.141

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (water)
	IsFixed: False
	Value: 0.8
	Formula: 0.8

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (water)-PT
	IsFixed: False
	Value: 0.718
	Formula: 0.718

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.158
	Formula: 0.158

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction interstitial
	IsFixed: False
	Value: 0.32
	Formula: 0.32

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0375
	Formula: 0.0375

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0483
	Formula: 0.0483

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0182
	Formula: 0.0182

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0124
	Formula: 0.0124

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.282
	Formula: 0.282

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (protein)-WS
	IsFixed: False
	Value: 0.15
	Formula: 0.15

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (water)-WS
	IsFixed: False
	Value: 0.78
	Formula: 0.78

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.456
	Formula: 0.456

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.41
	Formula: 2.41

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0035
	Formula: 0.0035

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.00101229310937703 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Volume(0.00101229310937703 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Volume
	IsFixed: False
	Value: 0.00101229310937703 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction vascular(0.13)
		V_org: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Volume(0.0146922076832661 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Volume(0.00101229310937703 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Volume(0.00101229310937703 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.000897693889447556 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|Volume(0.000897693889447556 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|Volume
	IsFixed: False
	Value: 0.000897693889447556 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction vascular(0.13)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Volume(0.0146922076832661 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|Volume(0.000897693889447556 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.00470150645864514 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume(0.00470150645864514 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume
	IsFixed: False
	Value: 0.00470150645864514 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction interstitial(0.32)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Volume(0.0146922076832661 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume(0.00470150645864514 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume(0.00470150645864514 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.0146922076832661 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Volume(0.0146922076832661 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Volume
	IsFixed: False
	Value: 0.00808071422579633 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction intracellular(0.55)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Volume(0.0146922076832661 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|pH
	IsFixed: False
	Value: 7.3
	Formula: 7.3

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Volume(0.00808071422579633 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume of protein container
	IsFixed: False
	Value: 1.08869258933002E-05 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume(1.08869258933002E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume
	IsFixed: False
	Value: 1.08869258933002E-05 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)(18.1448764888336 [dm²])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume(1.08869258933002E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume(1.08869258933002E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Large intestinal transit time factor
	IsFixed: False
	Value: 2535.176
	Formula: P1*LITT+P2
		LITT: PBPK_model_human_Ab|Organism|LargeIntestine|Large intestinal transit time(2652 [min])
		P2: PBPK_model_human_Ab|Organism|LargeIntestine|Large intestinal transit time factor intercept(47.6)
		P1: PBPK_model_human_Ab|Organism|LargeIntestine|Large intestinal transit time factor slope(0.938 [1/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Weight (tissue)
	IsFixed: False
	Value: 0.412481964175021 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|LargeIntestine|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Volume (mucosa)
	IsFixed: False
	Value: 0.0838988315131993 [l]
	Formula: V_cae+V_ca+V_ct+V_cd+V_cs+V_rec
		V_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Volume(0.00663853307431899 [l])
		V_ca: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Volume(0.012170644492062 [l])
		V_cd: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Volume(0.0138593939962807 [l])
		V_cs: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Volume(0.0167055195490884 [l])
		V_ct: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Volume(0.0277187879925614 [l])
		V_rec: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Volume(0.00680595240888785 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Fluid recirculation flow rate (incl. mucosa)
	IsFixed: False
	Value: 3.09817248650303E-05 [l/min]
	Formula: f_Jiso * (1-alpha_l) * Q_lymph * (V/V_mouse)^(exp_Jiso_scale - 1)
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Flow fraction via large pores(0.05)
		f_Jiso: PBPK_model_human_Ab|Organism|LargeIntestine|Fluid recirculation flow proportionality factor(0.179)
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate(0.0015811341483735 [l/min])
		V_mouse: PBPK_model_human_Ab|Organism|LargeIntestine|Organ volume mouse(0.000627 [l])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		exp_Jiso_scale: PBPK_model_human_Ab|Organism|Scaling exponent for fluid recirculation flow rate(0.667)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate
	IsFixed: False
	Value: 0.0015811341483735 [l/min]
	Formula: Q_lymph_incl_Mucosa-Q_lymph_cae-Q_lymph_colasc-Q_lymph_coltrans-Q_lymph_coldesc-Q_lymph_colsigm-Q_lymph_rect
		Q_lymph_incl_Mucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate (incl. mucosa)(0.00198485331204306 [l/min])
		Q_lymph_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Lymph flow rate(3.19444618288292E-05 [l/min])
		Q_lymph_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Lymph flow rate(5.85648492003344E-05 [l/min])
		Q_lymph_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Lymph flow rate(6.66910712846469E-05 [l/min])
		Q_lymph_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Lymph flow rate(8.0386559137744E-05 [l/min])
		Q_lymph_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Lymph flow rate(0.000133382142569294 [l/min])
		Q_lymph_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Lymph flow rate(3.27500796487105E-05 [l/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate (incl. mucosa)
	IsFixed: False
	Value: 0.00198485331204306 [l/min]
	Formula: f_lymph*Q*(1-HCT)
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Blood flow rate(0.260069878412351 [l/min])
		f_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow proportionality factor(0.0144)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Volume (endothelium)
	IsFixed: False
	Value: 0.000224750862740686 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)(74.9169542468954 [dm²])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Fluid recirculation flow rate
	IsFixed: False
	Value: 2.46800420274831E-05 [l/min]
	Formula: J_iso_incl_Mucosa-J_iso_cae-J_iso_colasc-J_iso_coltrans-J_iso_coldesc-J_iso_colsigm-J_iso_rect
		J_iso_incl_Mucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Fluid recirculation flow rate (incl. mucosa)(3.09817248650303E-05 [l/min])
		J_iso_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fluid recirculation flow rate(4.98623511035952E-07 [l/min])
		J_iso_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fluid recirculation flow rate(9.14143142809429E-07 [l/min])
		J_iso_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fluid recirculation flow rate(1.04098595546502E-06 [l/min])
		J_iso_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fluid recirculation flow rate(1.25475985703373E-06 [l/min])
		J_iso_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fluid recirculation flow rate(2.08197191093004E-06 [l/min])
		J_iso_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fluid recirculation flow rate(5.11198460273E-07 [l/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction intracellular
	IsFixed: False
	Value: 0.882
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction interstitial(0.094)
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction vascular(0.024)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Blood flow rate
	IsFixed: False
	Value: 0.260069878412351 [l/min]
	Formula: Qspec * Weight
		Qspec: PBPK_model_human_Ab|Organism|LargeIntestine|Specific blood flow rate(0.6305 [l/min/kg organ])
		Weight: PBPK_model_human_Ab|Organism|LargeIntestine|Weight (tissue)(0.412481964175021 [kg])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow proportionality factor
	IsFixed: False
	Value: 0.0144
	Formula: 0.0144

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Organ volume mouse
	IsFixed: False
	Value: 0.000627 [l]
	Formula: 0.000627

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Fluid recirculation flow proportionality factor
	IsFixed: False
	Value: 0.179
	Formula: 0.179

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Allometric scale factor
	IsFixed: False
	Value: 0.75
	Formula: 0.75

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa blood flow fraction
	IsFixed: False
	Value: 0.75
	Formula: 0.75

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Large intestinal transit time factor slope
	IsFixed: False
	Value: 0.938 [1/min]
	Formula: 0.938

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Large intestinal transit time factor intercept
	IsFixed: False
	Value: 47.6
	Formula: 47.6

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Hydraulic conductivity
	IsFixed: False
	Value: 1.86944444444444E-10 [l/min/(kg*dm/min²)]
	Formula: 1.86944444444444E-10

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (lipid)
	IsFixed: False
	Value: 0.062
	Formula: 0.062

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0487
	Formula: 0.0487

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction vascular
	IsFixed: False
	Value: 0.024
	Formula: 0.024

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0163
	Formula: 0.0163

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (protein)
	IsFixed: False
	Value: 0.133
	Formula: 0.133

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.158
	Formula: 0.158

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (water)-PT
	IsFixed: False
	Value: 0.718
	Formula: 0.718

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.141
	Formula: 0.141

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (water)
	IsFixed: False
	Value: 0.792
	Formula: 0.792

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction interstitial
	IsFixed: False
	Value: 0.094
	Formula: 0.094

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0483
	Formula: 0.0483

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0375
	Formula: 0.0375

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0124
	Formula: 0.0124

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0182
	Formula: 0.0182

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (protein)-WS
	IsFixed: False
	Value: 0.15
	Formula: 0.15

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.282
	Formula: 0.282

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.456
	Formula: 0.456

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (water)-WS
	IsFixed: False
	Value: 0.78
	Formula: 0.78

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0035
	Formula: 0.0035

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.41
	Formula: 2.41

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Large intestinal transit time
	IsFixed: False
	Value: 2652 [min]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Volume
	IsFixed: False
	Value: 0.412481964175021 [l]
	Percentile: 0.50153664121401

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Specific blood flow rate
	IsFixed: False
	Value: 0.6305 [l/min/kg organ]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.00417957744745837 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|Volume(0.00417957744745837 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|Volume
	IsFixed: False
	Value: 0.00417957744745837 [l]
	Formula: f_vas*(1-HCT)*(V-V_Mucosa)
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction vascular(0.024)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_Mucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Volume (mucosa)(0.0838988315131993 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|Volume(0.00417957744745837 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|Volume(0.00417957744745837 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.00370641773642535 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|Volume(0.00370641773642535 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|Volume
	IsFixed: False
	Value: 0.00370641773642535 [l]
	Formula: f_vas*HCT*(V-V_Mucosa)
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction vascular(0.024)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_Mucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Volume (mucosa)(0.0838988315131993 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|Volume(0.00370641773642535 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.0308868144702113 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|Volume(0.0308868144702113 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|Volume
	IsFixed: False
	Value: 0.0308868144702113 [l]
	Formula: f_int*(V-V_Mucosa)
		f_int: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction interstitial(0.094)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_Mucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Volume (mucosa)(0.0838988315131993 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|Volume(0.0308868144702113 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|Volume(0.0308868144702113 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.328583132661822 [l]
	Formula: Volume-V_Mucosa
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_Mucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Volume (mucosa)(0.0838988315131993 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|Volume
	IsFixed: False
	Value: 0.289810323007727 [l]
	Formula: f_cell*(V-V_Mucosa)
		f_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction intracellular(0.882)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_Mucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Volume (mucosa)(0.0838988315131993 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|pH
	IsFixed: False
	Value: 7.4
	Formula: 7.4

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|Volume(0.289810323007727 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.22908131578533
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|Partition coefficient (intracellular/water)(1.22908131578533)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|Volume of protein container
	IsFixed: False
	Value: 4.49501725481372E-05 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|Volume(4.49501725481372E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|Volume
	IsFixed: False
	Value: 4.49501725481372E-05 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)(74.9169542468954 [dm²])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|Volume(4.49501725481372E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|Volume(4.49501725481372E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Weight (tissue)
	IsFixed: False
	Value: 0.00663853307431899 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Volume(0.00663853307431899 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Volume
	IsFixed: False
	Value: 0.00663853307431899 [l]
	Formula: V_GutWall*fractionMucosa
		fractionMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction mucosa(0.19)
		V_GutWall: PBPK_model_human_Ab|Organism|Lumen|Caecum|Volume (gut wall)(0.0349396477595736 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Lymph flow rate
	IsFixed: False
	Value: 3.19444618288292E-05 [l/min]
	Formula: Q_lymph_intestine * V_seg / V_intestine
		Q_lymph_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate (incl. mucosa)(0.00198485331204306 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_seg: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Volume(0.00663853307431899 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fluid recirculation flow rate
	IsFixed: False
	Value: 4.98623511035952E-07 [l/min]
	Formula: J_iso_intestine * V_seg / V_intestine
		J_iso_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Fluid recirculation flow rate (incl. mucosa)(3.09817248650303E-05 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_seg: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Volume(0.00663853307431899 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Volume (endothelium)
	IsFixed: False
	Value: 2.45957650403519E-05 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)(8.19858834678396 [dm²])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Blood flow rate
	IsFixed: False
	Value: 0.0165221093405974 [l/min]
	Formula: Q * fractQ * regionalFractQ
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Blood flow rate(0.260069878412351 [l/min])
		regionalFractQ: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction of regional blood flow rate(0.084706)
		fractQ: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa blood flow fraction(0.75)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction intracellular
	IsFixed: False
	Value: 0.14
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction interstitial(0.73)
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction vascular(0.13)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction mucosa
	IsFixed: False
	Value: 0.19
	Formula: 0.19

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction of regional blood flow rate
	IsFixed: False
	Value: 0.084706
	Formula: 0.084706

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Hydraulic conductivity
	IsFixed: False
	Value: 1.86944444444444E-10 [l/min/(kg*dm/min²)]
	Formula: 1.86944444444444E-10

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (lipid)
	IsFixed: False
	Value: 0.06
	Formula: 0.06

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0487
	Formula: 0.0487

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction vascular
	IsFixed: False
	Value: 0.13
	Formula: 0.13

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0163
	Formula: 0.0163

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (protein)
	IsFixed: False
	Value: 0.08
	Formula: 0.08

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (water)-PT
	IsFixed: False
	Value: 0.718
	Formula: 0.718

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (water)
	IsFixed: False
	Value: 0.8
	Formula: 0.8

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.158
	Formula: 0.158

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.141
	Formula: 0.141

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction interstitial
	IsFixed: False
	Value: 0.73
	Formula: 0.73

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0483
	Formula: 0.0483

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0375
	Formula: 0.0375

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0182
	Formula: 0.0182

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0124
	Formula: 0.0124

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (protein)-WS
	IsFixed: False
	Value: 0.15
	Formula: 0.15

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.282
	Formula: 0.282

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.456
	Formula: 0.456

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (water)-WS
	IsFixed: False
	Value: 0.78
	Formula: 0.78

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.41
	Formula: 2.41

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0035
	Formula: 0.0035

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.000457394928820579 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|Volume(0.000457394928820579 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|Volume
	IsFixed: False
	Value: 0.000457394928820579 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction vascular(0.13)
		V_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Volume(0.00663853307431899 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|Volume(0.000457394928820579 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|Volume(0.000457394928820579 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.00040561437084089 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|Volume(0.00040561437084089 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|Volume
	IsFixed: False
	Value: 0.00040561437084089 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction vascular(0.13)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Volume(0.00663853307431899 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|Volume(0.00040561437084089 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.00484612914425286 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume(0.00484612914425286 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume
	IsFixed: False
	Value: 0.00484612914425286 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction interstitial(0.73)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Volume(0.00663853307431899 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume(0.00484612914425286 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume(0.00484612914425286 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.00663853307431899 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Volume(0.00663853307431899 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Volume
	IsFixed: False
	Value: 0.000929394630404659 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction intracellular(0.14)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Volume(0.00663853307431899 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|pH
	IsFixed: False
	Value: 7.3
	Formula: 7.3

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Volume(0.000929394630404659 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume of protein container
	IsFixed: False
	Value: 4.91915300807037E-06 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume(4.91915300807037E-06 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume
	IsFixed: False
	Value: 4.91915300807037E-06 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)(8.19858834678396 [dm²])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume(4.91915300807037E-06 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume(4.91915300807037E-06 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Weight (tissue)
	IsFixed: False
	Value: 0.012170644492062 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Volume(0.012170644492062 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Volume
	IsFixed: False
	Value: 0.012170644492062 [l]
	Formula: V_GutWall*fractionMucosa
		fractionMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction mucosa(0.19)
		V_GutWall: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Volume (gut wall)(0.0640560236424314 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Volume (endothelium)
	IsFixed: False
	Value: 4.50922378430896E-05 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)(15.0307459476965 [dm²])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fluid recirculation flow rate
	IsFixed: False
	Value: 9.14143142809429E-07 [l/min]
	Formula: J_iso_intestine * V_seg / V_intestine
		J_iso_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Fluid recirculation flow rate (incl. mucosa)(3.09817248650303E-05 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_seg: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Volume(0.012170644492062 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Lymph flow rate
	IsFixed: False
	Value: 5.85648492003344E-05 [l/min]
	Formula: Q_lymph_intestine * V_seg / V_intestine
		Q_lymph_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate (incl. mucosa)(0.00198485331204306 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_seg: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Volume(0.012170644492062 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Blood flow rate
	IsFixed: False
	Value: 0.0302896885639905 [l/min]
	Formula: Q * fractQ * regionalFractQ
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Blood flow rate(0.260069878412351 [l/min])
		regionalFractQ: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction of regional blood flow rate(0.15529)
		fractQ: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa blood flow fraction(0.75)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction intracellular
	IsFixed: False
	Value: 0.14
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction interstitial(0.73)
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction vascular(0.13)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction mucosa
	IsFixed: False
	Value: 0.19
	Formula: 0.19

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction of regional blood flow rate
	IsFixed: False
	Value: 0.15529
	Formula: 0.15529

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Hydraulic conductivity
	IsFixed: False
	Value: 1.86944444444444E-10 [l/min/(kg*dm/min²)]
	Formula: 1.86944444444444E-10

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (lipid)
	IsFixed: False
	Value: 0.06
	Formula: 0.06

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0487
	Formula: 0.0487

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction vascular
	IsFixed: False
	Value: 0.13
	Formula: 0.13

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0163
	Formula: 0.0163

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (protein)
	IsFixed: False
	Value: 0.08
	Formula: 0.08

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.158
	Formula: 0.158

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.141
	Formula: 0.141

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (water)-PT
	IsFixed: False
	Value: 0.718
	Formula: 0.718

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (water)
	IsFixed: False
	Value: 0.8
	Formula: 0.8

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction interstitial
	IsFixed: False
	Value: 0.73
	Formula: 0.73

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0375
	Formula: 0.0375

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0483
	Formula: 0.0483

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0124
	Formula: 0.0124

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0182
	Formula: 0.0182

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (protein)-WS
	IsFixed: False
	Value: 0.15
	Formula: 0.15

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.282
	Formula: 0.282

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (water)-WS
	IsFixed: False
	Value: 0.78
	Formula: 0.78

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.456
	Formula: 0.456

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0035
	Formula: 0.0035

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.41
	Formula: 2.41

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.00083855740550307 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Volume(0.00083855740550307 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Volume
	IsFixed: False
	Value: 0.00083855740550307 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction vascular(0.13)
		V_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Volume(0.012170644492062 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Volume(0.00083855740550307 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Volume(0.00083855740550307 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.000743626378464987 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|Volume(0.000743626378464987 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|Volume
	IsFixed: False
	Value: 0.000743626378464987 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction vascular(0.13)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Volume(0.012170644492062 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|Volume(0.000743626378464987 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.00888457047920524 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume(0.00888457047920524 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume
	IsFixed: False
	Value: 0.00888457047920524 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction interstitial(0.73)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Volume(0.012170644492062 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume(0.00888457047920524 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume(0.00888457047920524 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.012170644492062 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Volume(0.012170644492062 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Volume
	IsFixed: False
	Value: 0.00170389022888868 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction intracellular(0.14)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Volume(0.012170644492062 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|pH
	IsFixed: False
	Value: 7.3
	Formula: 7.3

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Volume(0.00170389022888868 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume of protein container
	IsFixed: False
	Value: 9.01844756861792E-06 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume(9.01844756861792E-06 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume
	IsFixed: False
	Value: 9.01844756861792E-06 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)(15.0307459476965 [dm²])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume(9.01844756861792E-06 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume(9.01844756861792E-06 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Weight (tissue)
	IsFixed: False
	Value: 0.0277187879925614 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Volume(0.0277187879925614 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Volume
	IsFixed: False
	Value: 0.0277187879925614 [l]
	Formula: V_GutWall*fractionMucosa
		fractionMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction mucosa(0.21)
		V_GutWall: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Volume (gut wall)(0.131994228536007 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fluid recirculation flow rate
	IsFixed: False
	Value: 2.08197191093004E-06 [l/min]
	Formula: J_iso_intestine * V_seg / V_intestine
		J_iso_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Fluid recirculation flow rate (incl. mucosa)(3.09817248650303E-05 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_seg: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Volume(0.0277187879925614 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Lymph flow rate
	IsFixed: False
	Value: 0.000133382142569294 [l/min]
	Formula: Q_lymph_intestine * V_seg / V_intestine
		Q_lymph_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate (incl. mucosa)(0.00198485331204306 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_seg: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Volume(0.0277187879925614 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Volume (endothelium)
	IsFixed: False
	Value: 9.47982549345601E-05 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)(31.59941831152 [dm²])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Blood flow rate
	IsFixed: False
	Value: 0.0624167708189642 [l/min]
	Formula: Q * fractQ * regionalFractQ
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Blood flow rate(0.260069878412351 [l/min])
		regionalFractQ: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction of regional blood flow rate(0.32)
		fractQ: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa blood flow fraction(0.75)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction intracellular
	IsFixed: False
	Value: 0.14
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction interstitial(0.74)
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction vascular(0.12)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction of regional blood flow rate
	IsFixed: False
	Value: 0.32
	Formula: 0.32

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction mucosa
	IsFixed: False
	Value: 0.21
	Formula: 0.21

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Hydraulic conductivity
	IsFixed: False
	Value: 1.86944444444444E-10 [l/min/(kg*dm/min²)]
	Formula: 1.86944444444444E-10

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (lipid)
	IsFixed: False
	Value: 0.06
	Formula: 0.06

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0487
	Formula: 0.0487

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction vascular
	IsFixed: False
	Value: 0.12
	Formula: 0.12

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0163
	Formula: 0.0163

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (protein)
	IsFixed: False
	Value: 0.08
	Formula: 0.08

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.141
	Formula: 0.141

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (water)-PT
	IsFixed: False
	Value: 0.718
	Formula: 0.718

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.158
	Formula: 0.158

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (water)
	IsFixed: False
	Value: 0.8
	Formula: 0.8

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction interstitial
	IsFixed: False
	Value: 0.74
	Formula: 0.74

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0483
	Formula: 0.0483

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0375
	Formula: 0.0375

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0182
	Formula: 0.0182

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0124
	Formula: 0.0124

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (protein)-WS
	IsFixed: False
	Value: 0.15
	Formula: 0.15

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.282
	Formula: 0.282

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.456
	Formula: 0.456

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (water)-WS
	IsFixed: False
	Value: 0.78
	Formula: 0.78

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.41
	Formula: 2.41

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0035
	Formula: 0.0035

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.00176291491632691 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Volume(0.00176291491632691 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Volume
	IsFixed: False
	Value: 0.00176291491632691 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction vascular(0.12)
		V_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Volume(0.0277187879925614 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Volume(0.00176291491632691 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Volume(0.00176291491632691 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.00156333964278046 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|Volume(0.00156333964278046 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|Volume
	IsFixed: False
	Value: 0.00156333964278046 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction vascular(0.12)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Volume(0.0277187879925614 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|Volume(0.00156333964278046 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.0205119031144955 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume(0.0205119031144955 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume
	IsFixed: False
	Value: 0.0205119031144955 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction interstitial(0.74)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Volume(0.0277187879925614 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume(0.0205119031144955 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume(0.0205119031144955 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.0277187879925614 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Volume(0.0277187879925614 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Volume
	IsFixed: False
	Value: 0.0038806303189586 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction intracellular(0.14)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Volume(0.0277187879925614 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|pH
	IsFixed: False
	Value: 7.3
	Formula: 7.3

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Volume(0.0038806303189586 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume of protein container
	IsFixed: False
	Value: 1.8959650986912E-05 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume(1.8959650986912E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume
	IsFixed: False
	Value: 1.8959650986912E-05 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)(31.59941831152 [dm²])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume(1.8959650986912E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume(1.8959650986912E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Weight (tissue)
	IsFixed: False
	Value: 0.0138593939962807 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Volume(0.0138593939962807 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Volume
	IsFixed: False
	Value: 0.0138593939962807 [l]
	Formula: V_GutWall*fractionMucosa
		fractionMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction mucosa(0.14)
		V_GutWall: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Volume (gut wall)(0.0989956714020051 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Lymph flow rate
	IsFixed: False
	Value: 6.66910712846469E-05 [l/min]
	Formula: Q_lymph_intestine * V_seg / V_intestine
		Q_lymph_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate (incl. mucosa)(0.00198485331204306 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_seg: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Volume(0.0138593939962807 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fluid recirculation flow rate
	IsFixed: False
	Value: 1.04098595546502E-06 [l/min]
	Formula: J_iso_intestine * V_seg / V_intestine
		J_iso_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Fluid recirculation flow rate (incl. mucosa)(3.09817248650303E-05 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_seg: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Volume(0.0138593939962807 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Volume (endothelium)
	IsFixed: False
	Value: 4.739912746728E-05 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)(15.79970915576 [dm²])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Blood flow rate
	IsFixed: False
	Value: 0.0468125781142232 [l/min]
	Formula: Q * fractQ * regionalFractQ
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Blood flow rate(0.260069878412351 [l/min])
		regionalFractQ: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction of regional blood flow rate(0.24)
		fractQ: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa blood flow fraction(0.75)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction intracellular
	IsFixed: False
	Value: 0.14
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction interstitial(0.74)
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction vascular(0.12)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction of regional blood flow rate
	IsFixed: False
	Value: 0.24
	Formula: 0.24

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction mucosa
	IsFixed: False
	Value: 0.14
	Formula: 0.14

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Hydraulic conductivity
	IsFixed: False
	Value: 1.86944444444444E-10 [l/min/(kg*dm/min²)]
	Formula: 1.86944444444444E-10

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (lipid)
	IsFixed: False
	Value: 0.06
	Formula: 0.06

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0487
	Formula: 0.0487

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction vascular
	IsFixed: False
	Value: 0.12
	Formula: 0.12

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (protein)
	IsFixed: False
	Value: 0.08
	Formula: 0.08

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0163
	Formula: 0.0163

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.158
	Formula: 0.158

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.141
	Formula: 0.141

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (water)
	IsFixed: False
	Value: 0.8
	Formula: 0.8

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (water)-PT
	IsFixed: False
	Value: 0.718
	Formula: 0.718

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction interstitial
	IsFixed: False
	Value: 0.74
	Formula: 0.74

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0483
	Formula: 0.0483

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0375
	Formula: 0.0375

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0124
	Formula: 0.0124

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0182
	Formula: 0.0182

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.282
	Formula: 0.282

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (protein)-WS
	IsFixed: False
	Value: 0.15
	Formula: 0.15

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.456
	Formula: 0.456

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (water)-WS
	IsFixed: False
	Value: 0.78
	Formula: 0.78

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0035
	Formula: 0.0035

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.41
	Formula: 2.41

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.000881457458163453 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Volume(0.000881457458163453 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Volume
	IsFixed: False
	Value: 0.000881457458163453 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction vascular(0.12)
		V_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Volume(0.0138593939962807 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Volume(0.000881457458163453 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Volume(0.000881457458163453 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.000781669821390232 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|Volume(0.000781669821390232 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|Volume
	IsFixed: False
	Value: 0.000781669821390232 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction vascular(0.12)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Volume(0.0138593939962807 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|Volume(0.000781669821390232 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.0102559515572477 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume(0.0102559515572477 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume
	IsFixed: False
	Value: 0.0102559515572477 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction interstitial(0.74)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Volume(0.0138593939962807 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume(0.0102559515572477 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume(0.0102559515572477 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.0138593939962807 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Volume(0.0138593939962807 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Volume
	IsFixed: False
	Value: 0.0019403151594793 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction intracellular(0.14)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Volume(0.0138593939962807 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|pH
	IsFixed: False
	Value: 7.3
	Formula: 7.3

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Volume(0.0019403151594793 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume of protein container
	IsFixed: False
	Value: 9.47982549345601E-06 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume(9.47982549345601E-06 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume
	IsFixed: False
	Value: 9.47982549345601E-06 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)(15.79970915576 [dm²])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume(9.47982549345601E-06 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume(9.47982549345601E-06 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Weight (tissue)
	IsFixed: False
	Value: 0.0167055195490884 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Volume(0.0167055195490884 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Volume
	IsFixed: False
	Value: 0.0167055195490884 [l]
	Formula: V_GutWall*fractionMucosa
		fractionMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction mucosa(0.3)
		V_GutWall: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Volume (gut wall)(0.0556850651636279 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fluid recirculation flow rate
	IsFixed: False
	Value: 1.25475985703373E-06 [l/min]
	Formula: J_iso_intestine * V_seg / V_intestine
		J_iso_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Fluid recirculation flow rate (incl. mucosa)(3.09817248650303E-05 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_seg: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Volume(0.0167055195490884 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Volume (endothelium)
	IsFixed: False
	Value: 3.80885845719215E-05 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)(12.6961948573072 [dm²])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Lymph flow rate
	IsFixed: False
	Value: 8.0386559137744E-05 [l/min]
	Formula: Q_lymph_intestine * V_seg / V_intestine
		Q_lymph_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate (incl. mucosa)(0.00198485331204306 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_seg: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Volume(0.0167055195490884 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Blood flow rate
	IsFixed: False
	Value: 0.0263320751892505 [l/min]
	Formula: Q * fractQ * regionalFractQ
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Blood flow rate(0.260069878412351 [l/min])
		regionalFractQ: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction of regional blood flow rate(0.135)
		fractQ: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa blood flow fraction(0.75)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction intracellular
	IsFixed: False
	Value: 0.14
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction interstitial(0.78)
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction vascular(0.08)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction of regional blood flow rate
	IsFixed: False
	Value: 0.135
	Formula: 0.135

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction mucosa
	IsFixed: False
	Value: 0.3
	Formula: 0.3

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Hydraulic conductivity
	IsFixed: False
	Value: 1.86944444444444E-10 [l/min/(kg*dm/min²)]
	Formula: 1.86944444444444E-10

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (lipid)
	IsFixed: False
	Value: 0.06
	Formula: 0.06

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0487
	Formula: 0.0487

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction vascular
	IsFixed: False
	Value: 0.08
	Formula: 0.08

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0163
	Formula: 0.0163

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (protein)
	IsFixed: False
	Value: 0.08
	Formula: 0.08

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.158
	Formula: 0.158

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (water)
	IsFixed: False
	Value: 0.8
	Formula: 0.8

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.141
	Formula: 0.141

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (water)-PT
	IsFixed: False
	Value: 0.718
	Formula: 0.718

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction interstitial
	IsFixed: False
	Value: 0.78
	Formula: 0.78

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0375
	Formula: 0.0375

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0483
	Formula: 0.0483

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0182
	Formula: 0.0182

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0124
	Formula: 0.0124

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.282
	Formula: 0.282

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (protein)-WS
	IsFixed: False
	Value: 0.15
	Formula: 0.15

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (water)-WS
	IsFixed: False
	Value: 0.78
	Formula: 0.78

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.456
	Formula: 0.456

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.41
	Formula: 2.41

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0035
	Formula: 0.0035

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.000708314028881347 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Volume(0.000708314028881347 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Volume
	IsFixed: False
	Value: 0.000708314028881347 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction vascular(0.08)
		V_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Volume(0.0167055195490884 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Volume(0.000708314028881347 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Volume(0.000708314028881347 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.000628127535045722 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|Volume(0.000628127535045722 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|Volume
	IsFixed: False
	Value: 0.000628127535045722 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction vascular(0.08)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Volume(0.0167055195490884 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|Volume(0.000628127535045722 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.0130303052482889 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume(0.0130303052482889 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume
	IsFixed: False
	Value: 0.0130303052482889 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction interstitial(0.78)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Volume(0.0167055195490884 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume(0.0130303052482889 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume(0.0130303052482889 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.0167055195490884 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Volume(0.0167055195490884 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Volume
	IsFixed: False
	Value: 0.00233877273687237 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction intracellular(0.14)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Volume(0.0167055195490884 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|pH
	IsFixed: False
	Value: 7.3
	Formula: 7.3

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Volume(0.00233877273687237 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume of protein container
	IsFixed: False
	Value: 7.61771691438429E-06 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume(7.61771691438429E-06 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume
	IsFixed: False
	Value: 7.61771691438429E-06 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)(12.6961948573072 [dm²])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume(7.61771691438429E-06 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume(7.61771691438429E-06 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Weight (tissue)
	IsFixed: False
	Value: 0.00680595240888785 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Volume(0.00680595240888785 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Volume
	IsFixed: False
	Value: 0.00680595240888785 [l]
	Formula: V_GutWall*fractionMucosa
		fractionMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction mucosa(0.3)
		V_GutWall: PBPK_model_human_Ab|Organism|Lumen|Rectum|Volume (gut wall)(0.0226865080296262 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Volume (endothelium)
	IsFixed: False
	Value: 1.55175714922643E-05 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)(5.17252383075477 [dm²])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Lymph flow rate
	IsFixed: False
	Value: 3.27500796487105E-05 [l/min]
	Formula: Q_lymph_intestine * V_seg / V_intestine
		Q_lymph_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate (incl. mucosa)(0.00198485331204306 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_seg: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Volume(0.00680595240888785 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fluid recirculation flow rate
	IsFixed: False
	Value: 5.11198460273E-07 [l/min]
	Formula: J_iso_intestine * V_seg / V_intestine
		J_iso_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Fluid recirculation flow rate (incl. mucosa)(3.09817248650303E-05 [l/min])
		V_intestine: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_seg: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Volume(0.00680595240888785 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Blood flow rate
	IsFixed: False
	Value: 0.0107278824845095 [l/min]
	Formula: Q * fractQ * regionalFractQ
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Blood flow rate(0.260069878412351 [l/min])
		regionalFractQ: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction of regional blood flow rate(0.055)
		fractQ: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa blood flow fraction(0.75)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction intracellular
	IsFixed: False
	Value: 0.23
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction interstitial(0.69)
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction vascular(0.08)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction of regional blood flow rate
	IsFixed: False
	Value: 0.055
	Formula: 0.055

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction mucosa
	IsFixed: False
	Value: 0.3
	Formula: 0.3

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Hydraulic conductivity
	IsFixed: False
	Value: 1.86944444444444E-10 [l/min/(kg*dm/min²)]
	Formula: 1.86944444444444E-10

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (lipid)
	IsFixed: False
	Value: 0.06
	Formula: 0.06

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0487
	Formula: 0.0487

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction vascular
	IsFixed: False
	Value: 0.08
	Formula: 0.08

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (protein)
	IsFixed: False
	Value: 0.08
	Formula: 0.08

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0163
	Formula: 0.0163

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (water)-PT
	IsFixed: False
	Value: 0.718
	Formula: 0.718

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (water)
	IsFixed: False
	Value: 0.8
	Formula: 0.8

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.158
	Formula: 0.158

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.141
	Formula: 0.141

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction interstitial
	IsFixed: False
	Value: 0.69
	Formula: 0.69

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0483
	Formula: 0.0483

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0375
	Formula: 0.0375

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0124
	Formula: 0.0124

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0182
	Formula: 0.0182

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.282
	Formula: 0.282

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (protein)-WS
	IsFixed: False
	Value: 0.15
	Formula: 0.15

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.456
	Formula: 0.456

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (water)-WS
	IsFixed: False
	Value: 0.78
	Formula: 0.78

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0035
	Formula: 0.0035

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.41
	Formula: 2.41

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.000288572382136845 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|Volume(0.000288572382136845 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|Volume
	IsFixed: False
	Value: 0.000288572382136845 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction vascular(0.08)
		V_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Volume(0.00680595240888785 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|Volume(0.000288572382136845 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|Volume(0.000288572382136845 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.000255903810574183 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|Volume(0.000255903810574183 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|Volume
	IsFixed: False
	Value: 0.000255903810574183 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction vascular(0.08)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Volume(0.00680595240888785 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|Volume(0.000255903810574183 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.00469610716213262 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume(0.00469610716213262 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume
	IsFixed: False
	Value: 0.00469610716213262 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction interstitial(0.69)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Volume(0.00680595240888785 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume(0.00469610716213262 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume(0.00469610716213262 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.00680595240888785 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Volume(0.00680595240888785 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Volume
	IsFixed: False
	Value: 0.00156536905404421 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction intracellular(0.23)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Volume(0.00680595240888785 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|pH
	IsFixed: False
	Value: 7.3
	Formula: 7.3

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Volume(0.00156536905404421 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume of protein container
	IsFixed: False
	Value: 3.10351429845286E-06 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume(3.10351429845286E-06 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume
	IsFixed: False
	Value: 3.10351429845286E-06 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)(5.17252383075477 [dm²])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume(3.10351429845286E-06 [l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume(3.10351429845286E-06 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Liver|Weight (tissue)
	IsFixed: False
	Value: 2.37659196630841 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|Liver|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|Liver|Volume(2.37659196630841 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Liver|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|Liver|Fluid recirculation flow rate
	IsFixed: False
	Value: 7.07876482920826E-05 [l/min]
	Formula: f_Jiso * (1-alpha_l) * Q_lymph * (V/V_mouse)^(exp_Jiso_scale - 1)
		alpha_l: PBPK_model_human_Ab|Organism|Liver|Flow fraction via large pores(0.8)
		f_Jiso: PBPK_model_human_Ab|Organism|Liver|Fluid recirculation flow proportionality factor(0.96)
		Q_lymph: PBPK_model_human_Ab|Organism|Liver|Lymph flow rate(0.00449682523507667 [l/min])
		V_mouse: PBPK_model_human_Ab|Organism|Liver|Organ volume mouse(0.0013 [l])
		V: PBPK_model_human_Ab|Organism|Liver|Volume(2.37659196630841 [l])
		exp_Jiso_scale: PBPK_model_human_Ab|Organism|Scaling exponent for fluid recirculation flow rate(0.667)

Parameter: PBPK_model_human_Ab|Organism|Liver|Lymph flow rate
	IsFixed: False
	Value: 0.00449682523507667 [l/min]
	Formula: f_lymph*Q*(1-HCT)
		Q: PBPK_model_human_Ab|Organism|Liver|Blood flow rate(0.426360598755729 [l/min])
		f_lymph: PBPK_model_human_Ab|Organism|Liver|Lymph flow proportionality factor(0.0199)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Liver|Volume (endothelium)
	IsFixed: False
	Value: 0.0115145880767643 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)(3838.19602558808 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction intracellular
	IsFixed: False
	Value: 0.667
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|Liver|Fraction interstitial(0.163)
		f_vas: PBPK_model_human_Ab|Organism|Liver|Fraction vascular(0.17)

Parameter: PBPK_model_human_Ab|Organism|Liver|Is liver zonated
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction of periportal zone
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|Liver|Blood flow rate
	IsFixed: False
	Value: 0.426360598755729 [l/min]
	Formula: Qspec * Weight
		Qspec: PBPK_model_human_Ab|Organism|Liver|Specific blood flow rate(0.1794 [l/min/kg organ])
		Weight: PBPK_model_human_Ab|Organism|Liver|Weight (tissue)(2.37659196630841 [kg])

Parameter: PBPK_model_human_Ab|Organism|Liver|Lymph flow proportionality factor
	IsFixed: False
	Value: 0.0199
	Formula: 0.0199

Parameter: PBPK_model_human_Ab|Organism|Liver|Organ volume mouse
	IsFixed: False
	Value: 0.0013 [l]
	Formula: 0.0013

Parameter: PBPK_model_human_Ab|Organism|Liver|Fluid recirculation flow proportionality factor
	IsFixed: False
	Value: 0.96
	Formula: 0.96

Parameter: PBPK_model_human_Ab|Organism|Liver|Allometric scale factor
	IsFixed: False
	Value: 0.75
	Formula: 0.75

Parameter: PBPK_model_human_Ab|Organism|Liver|EHC continuous fraction
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|Organism|Liver|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Liver|Flow fraction via large pores
	IsFixed: False
	Value: 0.8
	Formula: 0.8

Parameter: PBPK_model_human_Ab|Organism|Liver|Hydraulic conductivity
	IsFixed: False
	Value: 3.88888888888889E-11 [l/min/(kg*dm/min²)]
	Formula: 3.88888888888889E-11

Parameter: PBPK_model_human_Ab|Organism|Liver|Radius (small pores)
	IsFixed: False
	Value: 9E-08 [dm]
	Formula: 9E-08

Parameter: PBPK_model_human_Ab|Organism|Liver|Radius (large pores)
	IsFixed: False
	Value: 3.3E-07 [dm]
	Formula: 3.3E-07

Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (lipid)
	IsFixed: False
	Value: 0.069
	Formula: 0.069

Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0348
	Formula: 0.0348

Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction vascular
	IsFixed: False
	Value: 0.17
	Formula: 0.17

Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (protein)
	IsFixed: False
	Value: 0.184
	Formula: 0.184

Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0252
	Formula: 0.0252

Parameter: PBPK_model_human_Ab|Organism|Liver|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.161
	Formula: 0.161

Parameter: PBPK_model_human_Ab|Organism|Liver|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|Liver|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.086
	Formula: 0.086

Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (water)-PT
	IsFixed: False
	Value: 0.751
	Formula: 0.751

Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (water)
	IsFixed: False
	Value: 0.747
	Formula: 0.747

Parameter: PBPK_model_human_Ab|Organism|Liver|Number of cells/g tissue
	IsFixed: False
	Value: 139000 [x10^6/kg]
	Formula: 139000

Parameter: PBPK_model_human_Ab|Organism|Liver|Microsomal protein mass/g tissue
	IsFixed: False
	Value: 0.04 [kg/kg]
	Formula: 0.04

Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction interstitial
	IsFixed: False
	Value: 0.163
	Formula: 0.163

Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0135
	Formula: 0.0135

Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0232
	Formula: 0.0232

Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0238
	Formula: 0.0238

Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0472
	Formula: 0.0472

Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (protein)-WS
	IsFixed: False
	Value: 0.21
	Formula: 0.21

Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.161
	Formula: 0.161

Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.481
	Formula: 0.481

Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (water)-WS
	IsFixed: False
	Value: 0.68
	Formula: 0.68

Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0088
	Formula: 0.0088

Parameter: PBPK_model_human_Ab|Organism|Liver|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 4.56
	Formula: 4.56

Parameter: PBPK_model_human_Ab|Organism|Liver|Volume
	IsFixed: False
	Value: 2.37659196630841 [l]
	Percentile: 0.513559681776457

Parameter: PBPK_model_human_Ab|Organism|Liver|Specific blood flow rate
	IsFixed: False
	Value: 0.1794 [l/min/kg organ]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction of endosomal uptake from plasma(1)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Rate constant for recycling from endosomal space(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Weight (tissue)
	IsFixed: False
	Value: 2.37659196630841 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|Liver|Periportal|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|Liver|Periportal|Volume(2.37659196630841 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Rate constant for endosomal uptake(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction recycled to plasma(1)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction of blood for sampling(1)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction endosomal(0.2)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Density (tissue)(1 [kg/dm³])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Allometric scale factor
	IsFixed: False
	Value: 0.75
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Allometric scale factor(0.75)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Volume
	IsFixed: False
	Value: 2.37659196630841 [l]
	Formula: V_liv * (IsLiverZonated ? f_periportal : 1)
		f_periportal: PBPK_model_human_Ab|Organism|Liver|Fraction of periportal zone(0.5)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)
		V_liv: PBPK_model_human_Ab|Organism|Liver|Volume(2.37659196630841 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Hydraulic conductivity
	IsFixed: False
	Value: 3.88888888888889E-11 [l/min/(kg*dm/min²)]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Hydraulic conductivity(3.88888888888889E-11 [l/min/(kg*dm/min²)])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Radius (small pores)
	IsFixed: False
	Value: 9E-08 [dm]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Radius (small pores)(9E-08 [dm])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Volume (endothelium)
	IsFixed: False
	Value: 0.0115145880767643 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|Surface area (plasma/interstitial)(3838.19602558808 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Radius (large pores)
	IsFixed: False
	Value: 3.3E-07 [dm]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Radius (large pores)(3.3E-07 [dm])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Lymph flow rate
	IsFixed: False
	Value: 0.00449682523507667 [l/min]
	Formula: Q_lymph * (IsLiverZonated?  f_periportal : 1)
		Q_lymph: PBPK_model_human_Ab|Organism|Liver|Lymph flow rate(0.00449682523507667 [l/min])
		f_periportal: PBPK_model_human_Ab|Organism|Liver|Fraction of periportal zone(0.5)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Fluid recirculation flow rate
	IsFixed: False
	Value: 7.07876482920826E-05 [l/min]
	Formula: J_iso * (IsLiverZonated?  f_periportal : 1)
		J_iso: PBPK_model_human_Ab|Organism|Liver|Fluid recirculation flow rate(7.07876482920826E-05 [l/min])
		f_periportal: PBPK_model_human_Ab|Organism|Liver|Fraction of periportal zone(0.5)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Flow fraction via large pores
	IsFixed: False
	Value: 0.8
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Flow fraction via large pores(0.8)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0348
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (neutral lipid)-PT(0.0348)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (lipid)
	IsFixed: False
	Value: 0.069
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (lipid)(0.069)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0252
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (phospholipid)-PT(0.0252)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (protein)
	IsFixed: False
	Value: 0.184
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (protein)(0.184)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Microsomal protein mass/g tissue
	IsFixed: False
	Value: 0.04 [kg/kg]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Microsomal protein mass/g tissue(0.04 [kg/kg])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.086
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Albumin ratio (tissue/plasma)(0.086)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Albumin ratio (tissue/plasma)-PT(0.5)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (water)-PT
	IsFixed: False
	Value: 0.751
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (water)-PT(0.751)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (water)
	IsFixed: False
	Value: 0.747
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (water)(0.747)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Number of cells/g tissue
	IsFixed: False
	Value: 139000 [x10^6/kg]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Number of cells/g tissue(139000 [x10^6/kg])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.161
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Lipoprotein ratio (tissue/plasma)(0.161)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction vascular
	IsFixed: False
	Value: 0.17
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction vascular(0.17)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction intracellular
	IsFixed: False
	Value: 0.667
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction intracellular(0.667)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction interstitial
	IsFixed: False
	Value: 0.163
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction interstitial(0.163)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0135
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (neutral lipid)-RR(0.0135)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0232
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (neutral lipid)-WS(0.0232)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0472
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (neutral phospholipid, plasma)-WS(0.0472)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0238
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (neutral phospholipid)-RR(0.0238)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.161
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (extracellular water)-RR(0.161)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (protein)-WS
	IsFixed: False
	Value: 0.21
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (protein)-WS(0.21)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.481
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (intracellular water)-RR(0.481)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (water)-WS
	IsFixed: False
	Value: 0.68
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (water)-WS(0.68)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0088
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (acidic phospholipids)-WS(0.0088)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 4.56
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Acidic phospholipids [mg/g] - RR(4.56)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Specific blood flow rate
	IsFixed: False
	Value: 0.1794 [l/min/kg organ]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Specific blood flow rate(0.1794 [l/min/kg organ])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Blood flow rate
	IsFixed: False
	Value: 0.426360598755729 [l/min]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Blood flow rate(0.426360598755729 [l/min])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.214130936164388 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|Volume(0.214130936164388 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|Volume
	IsFixed: False
	Value: 0.214130936164388 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction vascular(0.17)
		V_org: PBPK_model_human_Ab|Organism|Liver|Periportal|Volume(2.37659196630841 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|Volume(0.214130936164388 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|Volume(0.214130936164388 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.189889698108042 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|Volume(0.189889698108042 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|Volume
	IsFixed: False
	Value: 0.189889698108042 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction vascular(0.17)
		V: PBPK_model_human_Ab|Organism|Liver|Periportal|Volume(2.37659196630841 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|Volume(0.189889698108042 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.387384490508271 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|Volume(0.387384490508271 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|Volume
	IsFixed: False
	Value: 0.387384490508271 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction interstitial(0.163)
		V: PBPK_model_human_Ab|Organism|Liver|Periportal|Volume(2.37659196630841 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|Volume(0.387384490508271 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|Volume(0.387384490508271 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|Volume of protein container
	IsFixed: False
	Value: 2.37659196630841 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Liver|Periportal|Volume(2.37659196630841 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|Volume
	IsFixed: False
	Value: 1.58518684152771 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction intracellular(0.667)
		V: PBPK_model_human_Ab|Organism|Liver|Periportal|Volume(2.37659196630841 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|pH
	IsFixed: False
	Value: 7.23
	Formula: pH_cell_Liver
		pH_cell_Liver: PBPK_model_human_Ab|Organism|Liver|Intracellular|pH(7.23)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|Volume(1.58518684152771 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.28715961852841
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|Partition coefficient (intracellular/water)(1.28715961852841)

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume of protein container
	IsFixed: False
	Value: 0.00230291761535285 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume(0.00230291761535285 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume
	IsFixed: False
	Value: 0.00230291761535285 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|Surface area (plasma/interstitial)(3838.19602558808 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume(0.00230291761535285 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume(0.00230291761535285 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction of endosomal uptake from plasma(1)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Weight (tissue)
	IsFixed: False
	Value: 0 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|Liver|Pericentral|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|Liver|Pericentral|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Rate constant for recycling from endosomal space(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Rate constant for endosomal uptake(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction recycled to plasma(1)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction of blood for sampling(1)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction endosomal(0.2)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Density (tissue)(1 [kg/dm³])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Allometric scale factor
	IsFixed: False
	Value: 0.75
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Allometric scale factor(0.75)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Volume
	IsFixed: False
	Value: 0 [l]
	Formula: V_liv * (IsLiverZonated ? 1 - f_periportal : 0)
		f_periportal: PBPK_model_human_Ab|Organism|Liver|Fraction of periportal zone(0.5)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)
		V_liv: PBPK_model_human_Ab|Organism|Liver|Volume(2.37659196630841 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Flow fraction via large pores
	IsFixed: False
	Value: 0.8
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Flow fraction via large pores(0.8)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Hydraulic conductivity
	IsFixed: False
	Value: 3.88888888888889E-11 [l/min/(kg*dm/min²)]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Hydraulic conductivity(3.88888888888889E-11 [l/min/(kg*dm/min²)])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Radius (large pores)
	IsFixed: False
	Value: 3.3E-07 [dm]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Radius (large pores)(3.3E-07 [dm])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Radius (small pores)
	IsFixed: False
	Value: 9E-08 [dm]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Radius (small pores)(9E-08 [dm])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Volume (endothelium)
	IsFixed: False
	Value: 0 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|Surface area (plasma/interstitial)(0 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fluid recirculation flow rate
	IsFixed: False
	Value: 0 [l/min]
	Formula: J_iso * (IsLiverZonated?  1-f_periportal : 0)
		J_iso: PBPK_model_human_Ab|Organism|Liver|Fluid recirculation flow rate(7.07876482920826E-05 [l/min])
		f_periportal: PBPK_model_human_Ab|Organism|Liver|Fraction of periportal zone(0.5)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Lymph flow rate
	IsFixed: False
	Value: 0 [l/min]
	Formula: Q_lymph * (IsLiverZonated?  1-f_periportal : 0)
		Q_lymph: PBPK_model_human_Ab|Organism|Liver|Lymph flow rate(0.00449682523507667 [l/min])
		f_periportal: PBPK_model_human_Ab|Organism|Liver|Fraction of periportal zone(0.5)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (lipid)
	IsFixed: False
	Value: 0.069
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (lipid)(0.069)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0348
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (neutral lipid)-PT(0.0348)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction vascular
	IsFixed: False
	Value: 0.17
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction vascular(0.17)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0252
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (phospholipid)-PT(0.0252)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (protein)
	IsFixed: False
	Value: 0.184
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (protein)(0.184)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.161
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Lipoprotein ratio (tissue/plasma)(0.161)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Number of cells/g tissue
	IsFixed: False
	Value: 139000 [x10^6/kg]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Number of cells/g tissue(139000 [x10^6/kg])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (water)-PT
	IsFixed: False
	Value: 0.751
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (water)-PT(0.751)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (water)
	IsFixed: False
	Value: 0.747
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (water)(0.747)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Microsomal protein mass/g tissue
	IsFixed: False
	Value: 0.04 [kg/kg]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Microsomal protein mass/g tissue(0.04 [kg/kg])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Albumin ratio (tissue/plasma)-PT(0.5)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.086
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Albumin ratio (tissue/plasma)(0.086)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction intracellular
	IsFixed: False
	Value: 0.667
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction intracellular(0.667)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction interstitial
	IsFixed: False
	Value: 0.163
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Fraction interstitial(0.163)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0135
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (neutral lipid)-RR(0.0135)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0232
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (neutral lipid)-WS(0.0232)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0238
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (neutral phospholipid)-RR(0.0238)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0472
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (neutral phospholipid, plasma)-WS(0.0472)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (protein)-WS
	IsFixed: False
	Value: 0.21
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (protein)-WS(0.21)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.161
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (extracellular water)-RR(0.161)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (water)-WS
	IsFixed: False
	Value: 0.68
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (water)-WS(0.68)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.481
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (intracellular water)-RR(0.481)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0088
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Vf (acidic phospholipids)-WS(0.0088)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 4.56
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Acidic phospholipids [mg/g] - RR(4.56)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Specific blood flow rate
	IsFixed: False
	Value: 0.1794 [l/min/kg organ]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Specific blood flow rate(0.1794 [l/min/kg organ])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Blood flow rate
	IsFixed: False
	Value: 0.426360598755729 [l/min]
	Formula: Liver_Parameter
		Liver_Parameter: PBPK_model_human_Ab|Organism|Liver|Blood flow rate(0.426360598755729 [l/min])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|Volume of protein container
	IsFixed: False
	Value: 0 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|Volume
	IsFixed: False
	Value: 0 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction vascular(0.17)
		V_org: PBPK_model_human_Ab|Organism|Liver|Pericentral|Volume(0 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|Volume
	IsFixed: False
	Value: 0 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction vascular(0.17)
		V: PBPK_model_human_Ab|Organism|Liver|Pericentral|Volume(0 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|Volume
	IsFixed: False
	Value: 0 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction interstitial(0.163)
		V: PBPK_model_human_Ab|Organism|Liver|Pericentral|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Liver|Pericentral|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|Volume
	IsFixed: False
	Value: 0 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction intracellular(0.667)
		V: PBPK_model_human_Ab|Organism|Liver|Pericentral|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|pH
	IsFixed: False
	Value: 7.23
	Formula: pH_cell_Liver
		pH_cell_Liver: PBPK_model_human_Ab|Organism|Liver|Intracellular|pH(7.23)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.28715961852841
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|Partition coefficient (intracellular/water)(1.28715961852841)

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume of protein container
	IsFixed: False
	Value: 0 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume
	IsFixed: False
	Value: 0 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|Surface area (plasma/interstitial)(0 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume(0 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Plasma|Volume
	IsFixed: False
	Value: 0.214130936164388 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|Liver|Fraction vascular(0.17)
		V_org: PBPK_model_human_Ab|Organism|Liver|Volume(2.37659196630841 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Liver|BloodCells|Volume
	IsFixed: False
	Value: 0.189889698108042 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|Liver|Fraction vascular(0.17)
		V: PBPK_model_human_Ab|Organism|Liver|Volume(2.37659196630841 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Liver|Interstitial|Volume
	IsFixed: False
	Value: 0.387384490508271 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|Liver|Fraction interstitial(0.163)
		V: PBPK_model_human_Ab|Organism|Liver|Volume(2.37659196630841 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|Liver|Intracellular|Volume
	IsFixed: False
	Value: 1.58518684152771 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|Liver|Fraction intracellular(0.667)
		V: PBPK_model_human_Ab|Organism|Liver|Volume(2.37659196630841 [l])

Parameter: PBPK_model_human_Ab|Organism|Liver|Intracellular|pH
	IsFixed: False
	Value: 7.23
	Formula: 7.23

Parameter: PBPK_model_human_Ab|Organism|Liver|Endosome|Volume
	IsFixed: False
	Value: 0.00230291761535285 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|Liver|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)(3838.19602558808 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Lung|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Lung|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Lung|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Lung|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|Lung|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Lung|Weight (tissue)
	IsFixed: False
	Value: 1.21437760044244 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|Lung|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|Lung|Volume(1.21437760044244 [l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Volume (endothelium)
	IsFixed: False
	Value: 0.0200736617353136 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)(6691.22057843786 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Lung|Fluid recirculation flow rate
	IsFixed: False
	Value: 4.76380931227607E-08 [l/min]
	Formula: f_Jiso * (1-alpha_l) * Q_lymph * (V/V_mouse)^(exp_Jiso_scale - 1)
		alpha_l: PBPK_model_human_Ab|Organism|Lung|Flow fraction via large pores(0.05)
		f_Jiso: PBPK_model_human_Ab|Organism|Lung|Fluid recirculation flow proportionality factor(0.01)
		Q_lymph: PBPK_model_human_Ab|Organism|Lung|Lymph flow rate(0.000114900141047345 [l/min])
		V_mouse: PBPK_model_human_Ab|Organism|Lung|Organ volume mouse(0.0001 [l])
		V: PBPK_model_human_Ab|Organism|Lung|Volume(1.21437760044244 [l])
		exp_Jiso_scale: PBPK_model_human_Ab|Organism|Scaling exponent for fluid recirculation flow rate(0.667)

Parameter: PBPK_model_human_Ab|Organism|Lung|Lymph flow rate
	IsFixed: False
	Value: 0.000114900141047345 [l/min]
	Formula: f_lymph*Q*(1-HCT)
		Q: PBPK_model_human_Ab|Organism|Lung|Blood flow rate(6.08968311677683 [l/min])
		f_lymph: PBPK_model_human_Ab|Organism|Lung|Lymph flow proportionality factor(3.56E-05)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Lung|Fraction intracellular
	IsFixed: False
	Value: 0.232
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|Lung|Fraction interstitial(0.188)
		f_vas: PBPK_model_human_Ab|Organism|Lung|Fraction vascular(0.58)

Parameter: PBPK_model_human_Ab|Organism|Lung|Blood flow rate
	IsFixed: False
	Value: 6.08968311677683 [l/min]
	Formula: Q_sto + Q_sin + Q_lin + Q_pan + Q_spl + Q_liv + Q_mus + Q_fat + Q_skn + Q_kid + Q_brn + Q_hrt + Q_bon + Q_tes
		Q_bon: PBPK_model_human_Ab|Organism|Bone|Blood flow rate(0.324956140036248 [l/min])
		Q_brn: PBPK_model_human_Ab|Organism|Brain|Blood flow rate(0.779859603835287 [l/min])
		Q_fat: PBPK_model_human_Ab|Organism|Fat|Blood flow rate(0.320135862220607 [l/min])
		Q_tes: PBPK_model_human_Ab|Organism|Gonads|Blood flow rate(0.00324568597653343 [l/min])
		Q_hrt: PBPK_model_human_Ab|Organism|Heart|Blood flow rate(0.260311982277266 [l/min])
		Q_kid: PBPK_model_human_Ab|Organism|Kidney|Blood flow rate(1.32718989688807 [l/min])
		Q_lin: PBPK_model_human_Ab|Organism|LargeIntestine|Blood flow rate(0.260069878412351 [l/min])
		Q_liv: PBPK_model_human_Ab|Organism|Liver|Blood flow rate(0.426360598755729 [l/min])
		Q_mus: PBPK_model_human_Ab|Organism|Muscle|Blood flow rate(1.1159695112837 [l/min])
		Q_pan: PBPK_model_human_Ab|Organism|Pancreas|Blood flow rate(0.0651108144964877 [l/min])
		Q_skn: PBPK_model_human_Ab|Organism|Skin|Blood flow rate(0.325306825387192 [l/min])
		Q_sin: PBPK_model_human_Ab|Organism|SmallIntestine|Blood flow rate(0.650318551621488 [l/min])
		Q_spl: PBPK_model_human_Ab|Organism|Spleen|Blood flow rate(0.165772755931134 [l/min])
		Q_sto: PBPK_model_human_Ab|Organism|Stomach|Blood flow rate(0.0650750096547275 [l/min])

Parameter: PBPK_model_human_Ab|Organism|Lung|Lymph flow proportionality factor
	IsFixed: False
	Value: 3.56E-05
	Formula: 3.56E-05

Parameter: PBPK_model_human_Ab|Organism|Lung|Organ volume mouse
	IsFixed: False
	Value: 0.0001 [l]
	Formula: 0.0001

Parameter: PBPK_model_human_Ab|Organism|Lung|Fluid recirculation flow proportionality factor
	IsFixed: False
	Value: 0.01
	Formula: 0.01

Parameter: PBPK_model_human_Ab|Organism|Lung|Allometric scale factor
	IsFixed: False
	Value: 0.75
	Formula: 0.75

Parameter: PBPK_model_human_Ab|Organism|Lung|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lung|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lung|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|Lung|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|Lung|Hydraulic conductivity
	IsFixed: False
	Value: 5.66666666666667E-12 [l/min/(kg*dm/min²)]
	Formula: 5.66666666666667E-12

Parameter: PBPK_model_human_Ab|Organism|Lung|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|Lung|Vf (lipid)
	IsFixed: False
	Value: 0.01
	Formula: 0.01

Parameter: PBPK_model_human_Ab|Organism|Lung|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.003
	Formula: 0.003

Parameter: PBPK_model_human_Ab|Organism|Lung|Vf (protein)
	IsFixed: False
	Value: 0.183
	Formula: 0.183

Parameter: PBPK_model_human_Ab|Organism|Lung|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.009
	Formula: 0.009

Parameter: PBPK_model_human_Ab|Organism|Lung|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lung|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.212
	Formula: 0.212

Parameter: PBPK_model_human_Ab|Organism|Lung|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.168
	Formula: 0.168

Parameter: PBPK_model_human_Ab|Organism|Lung|Vf (water)
	IsFixed: False
	Value: 0.807
	Formula: 0.807

Parameter: PBPK_model_human_Ab|Organism|Lung|Vf (water)-PT
	IsFixed: False
	Value: 0.811
	Formula: 0.811

Parameter: PBPK_model_human_Ab|Organism|Lung|Fraction interstitial
	IsFixed: False
	Value: 0.188
	Formula: 0.188

Parameter: PBPK_model_human_Ab|Organism|Lung|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0204
	Formula: 0.0204

Parameter: PBPK_model_human_Ab|Organism|Lung|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0215
	Formula: 0.0215

Parameter: PBPK_model_human_Ab|Organism|Lung|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0152
	Formula: 0.0152

Parameter: PBPK_model_human_Ab|Organism|Lung|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0123
	Formula: 0.0123

Parameter: PBPK_model_human_Ab|Organism|Lung|Vf (protein)-WS
	IsFixed: False
	Value: 0.11
	Formula: 0.11

Parameter: PBPK_model_human_Ab|Organism|Lung|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.336
	Formula: 0.336

Parameter: PBPK_model_human_Ab|Organism|Lung|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.238
	Formula: 0.238

Parameter: PBPK_model_human_Ab|Organism|Lung|Vf (water)-WS
	IsFixed: False
	Value: 0.74
	Formula: 0.74

Parameter: PBPK_model_human_Ab|Organism|Lung|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 3.91
	Formula: 3.91

Parameter: PBPK_model_human_Ab|Organism|Lung|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0044
	Formula: 0.0044

Parameter: PBPK_model_human_Ab|Organism|Lung|Volume
	IsFixed: False
	Value: 1.21437760044244 [l]
	Percentile: 0.403969897554758

Parameter: PBPK_model_human_Ab|Organism|Lung|Fraction vascular
	IsFixed: False
	Value: 0.58
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Lung|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.373299674376007 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lung|Plasma|Volume(0.373299674376007 [l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Plasma|Volume
	IsFixed: False
	Value: 0.373299674376007 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|Lung|Fraction vascular(0.58)
		V_org: PBPK_model_human_Ab|Organism|Lung|Volume(1.21437760044244 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lung|Plasma|Volume(0.373299674376007 [l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lung|Plasma|Volume(0.373299674376007 [l])

Parameter: PBPK_model_human_Ab|Organism|Lung|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.33103933388061 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lung|BloodCells|Volume(0.33103933388061 [l])

Parameter: PBPK_model_human_Ab|Organism|Lung|BloodCells|Volume
	IsFixed: False
	Value: 0.33103933388061 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|Lung|Fraction vascular(0.58)
		V: PBPK_model_human_Ab|Organism|Lung|Volume(1.21437760044244 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Lung|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lung|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lung|BloodCells|Volume(0.33103933388061 [l])

Parameter: PBPK_model_human_Ab|Organism|Lung|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|Lung|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.228302988883179 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lung|Interstitial|Volume(0.228302988883179 [l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Interstitial|Volume
	IsFixed: False
	Value: 0.228302988883179 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|Lung|Fraction interstitial(0.188)
		V: PBPK_model_human_Ab|Organism|Lung|Volume(1.21437760044244 [l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lung|Interstitial|Volume(0.228302988883179 [l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lung|Interstitial|Volume(0.228302988883179 [l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Intracellular|Volume of protein container
	IsFixed: False
	Value: 1.21437760044244 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lung|Volume(1.21437760044244 [l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Intracellular|Volume
	IsFixed: False
	Value: 0.281735603302647 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|Lung|Fraction intracellular(0.232)
		V: PBPK_model_human_Ab|Organism|Lung|Volume(1.21437760044244 [l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Intracellular|pH
	IsFixed: False
	Value: 6.6
	Formula: 6.6

Parameter: PBPK_model_human_Ab|Organism|Lung|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lung|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lung|Intracellular|Volume(0.281735603302647 [l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.19511249832262
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|Partition coefficient (intracellular/water)(1.19511249832262)

Parameter: PBPK_model_human_Ab|Organism|Lung|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Endosome|Volume of protein container
	IsFixed: False
	Value: 0.00401473234706272 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Lung|Endosome|Volume(0.00401473234706272 [l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Endosome|Volume
	IsFixed: False
	Value: 0.00401473234706272 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|Lung|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)(6691.22057843786 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lung|Endosome|Volume(0.00401473234706272 [l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lung|Endosome|Volume(0.00401473234706272 [l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Muscle|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Weight (tissue)
	IsFixed: False
	Value: 32.6402313917433 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|Muscle|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|Muscle|Volume(32.6402313917433 [l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Muscle|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|Muscle|Lymph flow rate
	IsFixed: False
	Value: 0.00118884232037053 [l/min]
	Formula: f_lymph*Q*(1-HCT)
		Q: PBPK_model_human_Ab|Organism|Muscle|Blood flow rate(1.1159695112837 [l/min])
		f_lymph: PBPK_model_human_Ab|Organism|Muscle|Lymph flow proportionality factor(0.00201)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Muscle|Volume (endothelium)
	IsFixed: False
	Value: 0.0232561648666171 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)(7752.05495553904 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Fluid recirculation flow rate
	IsFixed: False
	Value: 2.2292095155886E-05 [l/min]
	Formula: f_Jiso * (1-alpha_l) * Q_lymph * (V/V_mouse)^(exp_Jiso_scale - 1)
		alpha_l: PBPK_model_human_Ab|Organism|Muscle|Flow fraction via large pores(0.05)
		f_Jiso: PBPK_model_human_Ab|Organism|Muscle|Fluid recirculation flow proportionality factor(0.292)
		Q_lymph: PBPK_model_human_Ab|Organism|Muscle|Lymph flow rate(0.00118884232037053 [l/min])
		V_mouse: PBPK_model_human_Ab|Organism|Muscle|Organ volume mouse(0.01 [l])
		V: PBPK_model_human_Ab|Organism|Muscle|Volume(32.6402313917433 [l])
		exp_Jiso_scale: PBPK_model_human_Ab|Organism|Scaling exponent for fluid recirculation flow rate(0.667)

Parameter: PBPK_model_human_Ab|Organism|Muscle|Fraction intracellular
	IsFixed: False
	Value: 0.815
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|Muscle|Fraction interstitial(0.16)
		f_vas: PBPK_model_human_Ab|Organism|Muscle|Fraction vascular(0.025)

Parameter: PBPK_model_human_Ab|Organism|Muscle|Blood flow rate
	IsFixed: False
	Value: 1.1159695112837 [l/min]
	Formula: Qspec * Weight
		Qspec: PBPK_model_human_Ab|Organism|Muscle|Specific blood flow rate(0.03419 [l/min/kg organ])
		Weight: PBPK_model_human_Ab|Organism|Muscle|Weight (tissue)(32.6402313917433 [kg])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Lymph flow proportionality factor
	IsFixed: False
	Value: 0.00201
	Formula: 0.00201

Parameter: PBPK_model_human_Ab|Organism|Muscle|Organ volume mouse
	IsFixed: False
	Value: 0.01 [l]
	Formula: 0.01

Parameter: PBPK_model_human_Ab|Organism|Muscle|Fluid recirculation flow proportionality factor
	IsFixed: False
	Value: 0.292
	Formula: 0.292

Parameter: PBPK_model_human_Ab|Organism|Muscle|Allometric scale factor
	IsFixed: False
	Value: 2
	Formula: 2

Parameter: PBPK_model_human_Ab|Organism|Muscle|Peripheral blood flow fraction
	IsFixed: False
	Value: 0.287
	Formula: 0.287

Parameter: PBPK_model_human_Ab|Organism|Muscle|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Muscle|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Muscle|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|Muscle|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|Muscle|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|Muscle|Hydraulic conductivity
	IsFixed: False
	Value: 9E-12 [l/min/(kg*dm/min²)]
	Formula: 9E-12

Parameter: PBPK_model_human_Ab|Organism|Muscle|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.059
	Formula: 0.059

Parameter: PBPK_model_human_Ab|Organism|Muscle|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.064
	Formula: 0.064

Parameter: PBPK_model_human_Ab|Organism|Muscle|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Fraction vascular
	IsFixed: False
	Value: 0.025
	Formula: 0.025

Parameter: PBPK_model_human_Ab|Organism|Muscle|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 2.42
	Formula: 2.42

Parameter: PBPK_model_human_Ab|Organism|Muscle|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0009
	Formula: 0.0009

Parameter: PBPK_model_human_Ab|Organism|Muscle|Volume
	IsFixed: False
	Value: 32.6402313917433 [l]
	Percentile: 0.538793766449486

Parameter: PBPK_model_human_Ab|Organism|Muscle|Vf (lipid)
	IsFixed: False
	Value: 0.013
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0238
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Vf (protein)
	IsFixed: False
	Value: 0.177
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0072
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Vf (water)
	IsFixed: False
	Value: 0.811
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Vf (water)-PT
	IsFixed: False
	Value: 0.76
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Fraction interstitial
	IsFixed: False
	Value: 0.16
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0049
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.022
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0078
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0042
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.079
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Vf (protein)-WS
	IsFixed: False
	Value: 0.19
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.666
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Vf (water)-WS
	IsFixed: False
	Value: 0.76
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Specific blood flow rate
	IsFixed: False
	Value: 0.03419 [l/min/kg organ]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Muscle|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.432483065940599 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Muscle|Plasma|Volume(0.432483065940599 [l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Plasma|Volume
	IsFixed: False
	Value: 0.432483065940599 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|Muscle|Fraction vascular(0.025)
		V_org: PBPK_model_human_Ab|Organism|Muscle|Volume(32.6402313917433 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Muscle|Plasma|Volume(0.432483065940599 [l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Muscle|Plasma|Volume(0.432483065940599 [l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.383522718852984 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Muscle|BloodCells|Volume(0.383522718852984 [l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|BloodCells|Volume
	IsFixed: False
	Value: 0.383522718852984 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|Muscle|Fraction vascular(0.025)
		V: PBPK_model_human_Ab|Organism|Muscle|Volume(32.6402313917433 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Muscle|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Muscle|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Muscle|BloodCells|Volume(0.383522718852984 [l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|Muscle|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Interstitial|Volume of protein container
	IsFixed: False
	Value: 5.22243702267893 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Muscle|Interstitial|Volume(5.22243702267893 [l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Interstitial|Volume
	IsFixed: False
	Value: 5.22243702267893 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|Muscle|Fraction interstitial(0.16)
		V: PBPK_model_human_Ab|Organism|Muscle|Volume(32.6402313917433 [l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Muscle|Interstitial|Volume(5.22243702267893 [l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Muscle|Interstitial|Volume(5.22243702267893 [l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Intracellular|Volume of protein container
	IsFixed: False
	Value: 32.6402313917433 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Muscle|Volume(32.6402313917433 [l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Intracellular|Volume
	IsFixed: False
	Value: 26.6017885842708 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|Muscle|Fraction intracellular(0.815)
		V: PBPK_model_human_Ab|Organism|Muscle|Volume(32.6402313917433 [l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Intracellular|pH
	IsFixed: False
	Value: 6.81
	Formula: 6.81

Parameter: PBPK_model_human_Ab|Organism|Muscle|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Muscle|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Muscle|Intracellular|Volume(26.6017885842708 [l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.19080760296443
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|Partition coefficient (intracellular/water)(1.19080760296443)

Parameter: PBPK_model_human_Ab|Organism|Muscle|Endosome|Volume of protein container
	IsFixed: False
	Value: 0.00465123297332342 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Muscle|Endosome|Volume(0.00465123297332342 [l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Endosome|Volume
	IsFixed: False
	Value: 0.00465123297332342 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|Muscle|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)(7752.05495553904 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Muscle|Endosome|Volume(0.00465123297332342 [l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Muscle|Endosome|Volume(0.00465123297332342 [l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Weight (tissue)
	IsFixed: False
	Value: 0.19043818220675 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|Pancreas|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|Pancreas|Volume(0.19043818220675 [l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Fluid recirculation flow rate
	IsFixed: False
	Value: 8.76759089031544E-07 [l/min]
	Formula: f_Jiso * (1-alpha_l) * Q_lymph * (V/V_mouse)^(exp_Jiso_scale - 1)
		alpha_l: PBPK_model_human_Ab|Organism|Pancreas|Flow fraction via large pores(0.05)
		f_Jiso: PBPK_model_human_Ab|Organism|Pancreas|Fluid recirculation flow proportionality factor(0.01)
		Q_lymph: PBPK_model_human_Ab|Organism|Pancreas|Lymph flow rate(0.0010456145699991 [l/min])
		V_mouse: PBPK_model_human_Ab|Organism|Pancreas|Organ volume mouse(0.00013 [l])
		V: PBPK_model_human_Ab|Organism|Pancreas|Volume(0.19043818220675 [l])
		exp_Jiso_scale: PBPK_model_human_Ab|Organism|Scaling exponent for fluid recirculation flow rate(0.667)

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Lymph flow rate
	IsFixed: False
	Value: 0.0010456145699991 [l/min]
	Formula: f_lymph*Q*(1-HCT)
		Q: PBPK_model_human_Ab|Organism|Pancreas|Blood flow rate(0.0651108144964877 [l/min])
		f_lymph: PBPK_model_human_Ab|Organism|Pancreas|Lymph flow proportionality factor(0.0303)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Volume (endothelium)
	IsFixed: False
	Value: 0.00108549763857847 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)(361.832546192824 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Fraction intracellular
	IsFixed: False
	Value: 0.68
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|Pancreas|Fraction interstitial(0.12)
		f_vas: PBPK_model_human_Ab|Organism|Pancreas|Fraction vascular(0.2)

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Blood flow rate
	IsFixed: False
	Value: 0.0651108144964877 [l/min]
	Formula: Qspec * Weight
		Qspec: PBPK_model_human_Ab|Organism|Pancreas|Specific blood flow rate(0.3419 [l/min/kg organ])
		Weight: PBPK_model_human_Ab|Organism|Pancreas|Weight (tissue)(0.19043818220675 [kg])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Lymph flow proportionality factor
	IsFixed: False
	Value: 0.0303
	Formula: 0.0303

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Organ volume mouse
	IsFixed: False
	Value: 0.00013 [l]
	Formula: 0.00013

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Fluid recirculation flow proportionality factor
	IsFixed: False
	Value: 0.01
	Formula: 0.01

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Allometric scale factor
	IsFixed: False
	Value: 0.75
	Formula: 0.75

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Hydraulic conductivity
	IsFixed: False
	Value: 3.22222222222222E-11 [l/min/(kg*dm/min²)]
	Formula: 3.22222222222222E-11

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Vf (lipid)
	IsFixed: False
	Value: 0.08
	Formula: 0.08

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0403
	Formula: 0.0403

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Vf (protein)
	IsFixed: False
	Value: 0.13
	Formula: 0.13

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.01067
	Formula: 0.01067

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.06
	Formula: 0.06

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Vf (water)
	IsFixed: False
	Value: 0.71
	Formula: 0.71

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.06
	Formula: 0.06

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Vf (water)-PT
	IsFixed: False
	Value: 0.71
	Formula: 0.71

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Fraction vascular
	IsFixed: False
	Value: 0.2
	Formula: 0.2

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Fraction interstitial
	IsFixed: False
	Value: 0.12
	Formula: 0.12

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.0403
	Formula: 0.0403

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0403
	Formula: 0.0403

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.009
	Formula: 0.009

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.009
	Formula: 0.009

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Vf (protein)-WS
	IsFixed: False
	Value: 0.13
	Formula: 0.13

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.12
	Formula: 0.12

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.521
	Formula: 0.521

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Vf (water)-WS
	IsFixed: False
	Value: 0.71
	Formula: 0.71

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 1.67
	Formula: 1.67

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.00167
	Formula: 0.00167

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Volume
	IsFixed: False
	Value: 0.19043818220675 [l]
	Percentile: 0.501348473412321

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Specific blood flow rate
	IsFixed: False
	Value: 0.3419 [l/min/kg organ]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.0201864473139155 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Pancreas|Plasma|Volume(0.0201864473139155 [l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Plasma|Volume
	IsFixed: False
	Value: 0.0201864473139155 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|Pancreas|Fraction vascular(0.2)
		V_org: PBPK_model_human_Ab|Organism|Pancreas|Volume(0.19043818220675 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Pancreas|Plasma|Volume(0.0201864473139155 [l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Pancreas|Plasma|Volume(0.0201864473139155 [l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.0179011891274345 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|Volume(0.0179011891274345 [l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|Volume
	IsFixed: False
	Value: 0.0179011891274345 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|Pancreas|Fraction vascular(0.2)
		V: PBPK_model_human_Ab|Organism|Pancreas|Volume(0.19043818220675 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|Volume(0.0179011891274345 [l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.02285258186481 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|Volume(0.02285258186481 [l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|Volume
	IsFixed: False
	Value: 0.02285258186481 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|Pancreas|Fraction interstitial(0.12)
		V: PBPK_model_human_Ab|Organism|Pancreas|Volume(0.19043818220675 [l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|Volume(0.02285258186481 [l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|Volume(0.02285258186481 [l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.19043818220675 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Pancreas|Volume(0.19043818220675 [l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|Volume
	IsFixed: False
	Value: 0.12949796390059 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|Pancreas|Fraction intracellular(0.68)
		V: PBPK_model_human_Ab|Organism|Pancreas|Volume(0.19043818220675 [l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|pH
	IsFixed: False
	Value: 7.4
	Formula: 7.4

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|Volume(0.12949796390059 [l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.36774874200018
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|Partition coefficient (intracellular/water)(1.36774874200018)

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Endosome|Volume of protein container
	IsFixed: False
	Value: 0.000217099527715695 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Pancreas|Endosome|Volume(0.000217099527715695 [l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Endosome|Volume
	IsFixed: False
	Value: 0.000217099527715695 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|Pancreas|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)(361.832546192824 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Pancreas|Endosome|Volume(0.000217099527715695 [l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Pancreas|Endosome|Volume(0.000217099527715695 [l])

Parameter: PBPK_model_human_Ab|Organism|PortalVein|Weight (tissue)
	IsFixed: False
	Value: 1.03743652397304 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|PortalVein|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|PortalVein|Volume(1.03743652397304 [l])

Parameter: PBPK_model_human_Ab|Organism|PortalVein|Lymph flow rate
	IsFixed: False
	Value: 0.00552133646238733 [l/min]
	Formula: Q_Lymph_sto + Q_Lymph_sin_incl_Mucosa + Q_Lymph_lin_incl_Mucosa + Q_Lymph_pan + Q_Lymph_spl
		Q_Lymph_lin_incl_Mucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate (incl. mucosa)(0.00198485331204306 [l/min])
		Q_Lymph_pan: PBPK_model_human_Ab|Organism|Pancreas|Lymph flow rate(0.0010456145699991 [l/min])
		Q_Lymph_sin_incl_Mucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow rate (incl. mucosa)(0.000672104223100808 [l/min])
		Q_Lymph_spl: PBPK_model_human_Ab|Organism|Spleen|Lymph flow rate(0.00174840525680567 [l/min])
		Q_Lymph_sto: PBPK_model_human_Ab|Organism|Stomach|Lymph flow rate(7.03591004386913E-05 [l/min])

Parameter: PBPK_model_human_Ab|Organism|PortalVein|Blood flow rate
	IsFixed: False
	Value: 1.20634701011619 [l/min]
	Formula: Q_sto + Q_sin + Q_lin + Q_pan + Q_spl
		Q_lin: PBPK_model_human_Ab|Organism|LargeIntestine|Blood flow rate(0.260069878412351 [l/min])
		Q_pan: PBPK_model_human_Ab|Organism|Pancreas|Blood flow rate(0.0651108144964877 [l/min])
		Q_sin: PBPK_model_human_Ab|Organism|SmallIntestine|Blood flow rate(0.650318551621488 [l/min])
		Q_spl: PBPK_model_human_Ab|Organism|Spleen|Blood flow rate(0.165772755931134 [l/min])
		Q_sto: PBPK_model_human_Ab|Organism|Stomach|Blood flow rate(0.0650750096547275 [l/min])

Parameter: PBPK_model_human_Ab|Organism|PortalVein|Allometric scale factor
	IsFixed: False
	Value: 0.75
	Formula: 0.75

Parameter: PBPK_model_human_Ab|Organism|PortalVein|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|PortalVein|Fraction vascular
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|PortalVein|Volume
	IsFixed: False
	Value: 1.03743652397304 [l]
	Percentile: 0.50163653006359

Parameter: PBPK_model_human_Ab|Organism|PortalVein|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.549841357705713 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|PortalVein|Plasma|Volume(0.549841357705713 [l])

Parameter: PBPK_model_human_Ab|Organism|PortalVein|Plasma|Volume
	IsFixed: False
	Value: 0.549841357705713 [l]
	Formula: (1-HCT)*V
		f_vas: PBPK_model_human_Ab|Organism|PortalVein|Fraction vascular(1)
		V: PBPK_model_human_Ab|Organism|PortalVein|Volume(1.03743652397304 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|PortalVein|Plasma|Volume(0.549841357705713 [l])

Parameter: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.48759516626733 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|Volume(0.48759516626733 [l])

Parameter: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|Volume
	IsFixed: False
	Value: 0.48759516626733 [l]
	Formula: HCT*V
		V: PBPK_model_human_Ab|Organism|PortalVein|Volume(1.03743652397304 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|Volume(0.48759516626733 [l])

Parameter: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|Skin|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Skin|Weight (tissue)
	IsFixed: False
	Value: 3.76294766208435 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|Skin|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|Skin|Volume(3.76294766208435 [l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Skin|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Skin|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Skin|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|Skin|Fluid recirculation flow rate
	IsFixed: False
	Value: 3.26924996641784E-05 [l/min]
	Formula: f_Jiso * (1-alpha_l) * Q_lymph * (V/V_mouse)^(exp_Jiso_scale - 1)
		alpha_l: PBPK_model_human_Ab|Organism|Skin|Flow fraction via large pores(0.05)
		f_Jiso: PBPK_model_human_Ab|Organism|Skin|Fluid recirculation flow proportionality factor(0.617)
		Q_lymph: PBPK_model_human_Ab|Organism|Skin|Lymph flow rate(0.000606892413442345 [l/min])
		V_mouse: PBPK_model_human_Ab|Organism|Skin|Organ volume mouse(0.0029 [l])
		V: PBPK_model_human_Ab|Organism|Skin|Volume(3.76294766208435 [l])
		exp_Jiso_scale: PBPK_model_human_Ab|Organism|Scaling exponent for fluid recirculation flow rate(0.667)

Parameter: PBPK_model_human_Ab|Organism|Skin|Lymph flow rate
	IsFixed: False
	Value: 0.000606892413442345 [l/min]
	Formula: f_lymph*Q*(1-HCT)
		Q: PBPK_model_human_Ab|Organism|Skin|Blood flow rate(0.325306825387192 [l/min])
		f_lymph: PBPK_model_human_Ab|Organism|Skin|Lymph flow proportionality factor(0.00352)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Skin|Volume (endothelium)
	IsFixed: False
	Value: 0.00493322438499258 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)(1644.40812833086 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Skin|Fraction intracellular
	IsFixed: False
	Value: 0.652
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|Skin|Fraction interstitial(0.302)
		f_vas: PBPK_model_human_Ab|Organism|Skin|Fraction vascular(0.046)

Parameter: PBPK_model_human_Ab|Organism|Skin|Blood flow rate
	IsFixed: False
	Value: 0.325306825387192 [l/min]
	Formula: Qspec * Weight
		Qspec: PBPK_model_human_Ab|Organism|Skin|Specific blood flow rate(0.08645 [l/min/kg organ])
		Weight: PBPK_model_human_Ab|Organism|Skin|Weight (tissue)(3.76294766208435 [kg])

Parameter: PBPK_model_human_Ab|Organism|Skin|Lymph flow proportionality factor
	IsFixed: False
	Value: 0.00352
	Formula: 0.00352

Parameter: PBPK_model_human_Ab|Organism|Skin|Organ volume mouse
	IsFixed: False
	Value: 0.0029 [l]
	Formula: 0.0029

Parameter: PBPK_model_human_Ab|Organism|Skin|Fluid recirculation flow proportionality factor
	IsFixed: False
	Value: 0.617
	Formula: 0.617

Parameter: PBPK_model_human_Ab|Organism|Skin|Allometric scale factor
	IsFixed: False
	Value: 1.6
	Formula: 1.6

Parameter: PBPK_model_human_Ab|Organism|Skin|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Skin|Peripheral blood flow fraction
	IsFixed: False
	Value: 0.713
	Formula: 0.713

Parameter: PBPK_model_human_Ab|Organism|Skin|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Skin|Fraction vascular
	IsFixed: False
	Value: 0.046
	Formula: 0.046

Parameter: PBPK_model_human_Ab|Organism|Skin|Hydraulic conductivity
	IsFixed: False
	Value: 1.94722E-11 [l/min/(kg*dm/min²)]
	Formula: 1.94722E-11

Parameter: PBPK_model_human_Ab|Organism|Skin|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|Skin|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|Skin|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|Skin|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0284
	Formula: 0.0284

Parameter: PBPK_model_human_Ab|Organism|Skin|Vf (lipid)
	IsFixed: False
	Value: 0.1
	Formula: 0.1

Parameter: PBPK_model_human_Ab|Organism|Skin|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0111
	Formula: 0.0111

Parameter: PBPK_model_human_Ab|Organism|Skin|Vf (protein)
	IsFixed: False
	Value: 0.288
	Formula: 0.288

Parameter: PBPK_model_human_Ab|Organism|Skin|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.277
	Formula: 0.277

Parameter: PBPK_model_human_Ab|Organism|Skin|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|Skin|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.096
	Formula: 0.096

Parameter: PBPK_model_human_Ab|Organism|Skin|Vf (water)
	IsFixed: False
	Value: 0.612
	Formula: 0.612

Parameter: PBPK_model_human_Ab|Organism|Skin|Vf (water)-PT
	IsFixed: False
	Value: 0.718
	Formula: 0.718

Parameter: PBPK_model_human_Ab|Organism|Skin|Fraction interstitial
	IsFixed: False
	Value: 0.302
	Formula: 0.302

Parameter: PBPK_model_human_Ab|Organism|Skin|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0603
	Formula: 0.0603

Parameter: PBPK_model_human_Ab|Organism|Skin|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.126
	Formula: 0.126

Parameter: PBPK_model_human_Ab|Organism|Skin|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0112
	Formula: 0.0112

Parameter: PBPK_model_human_Ab|Organism|Skin|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0044
	Formula: 0.0044

Parameter: PBPK_model_human_Ab|Organism|Skin|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.382
	Formula: 0.382

Parameter: PBPK_model_human_Ab|Organism|Skin|Vf (protein)-WS
	IsFixed: False
	Value: 0.41
	Formula: 0.41

Parameter: PBPK_model_human_Ab|Organism|Skin|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.276
	Formula: 0.276

Parameter: PBPK_model_human_Ab|Organism|Skin|Vf (water)-WS
	IsFixed: False
	Value: 0.47
	Formula: 0.47

Parameter: PBPK_model_human_Ab|Organism|Skin|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.0028
	Formula: 0.0028

Parameter: PBPK_model_human_Ab|Organism|Skin|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 1.32
	Formula: 1.32

Parameter: PBPK_model_human_Ab|Organism|Skin|Volume
	IsFixed: False
	Value: 3.76294766208435 [l]
	Percentile: 0.504316615526718

Parameter: PBPK_model_human_Ab|Organism|Skin|Specific blood flow rate
	IsFixed: False
	Value: 0.08645 [l/min/kg organ]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Skin|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.0917406640016164 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Skin|Plasma|Volume(0.0917406640016164 [l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Plasma|Volume
	IsFixed: False
	Value: 0.0917406640016164 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|Skin|Fraction vascular(0.046)
		V_org: PBPK_model_human_Ab|Organism|Skin|Volume(3.76294766208435 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Skin|Plasma|Volume(0.0917406640016164 [l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Skin|Plasma|Volume(0.0917406640016164 [l])

Parameter: PBPK_model_human_Ab|Organism|Skin|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.0813549284542636 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Skin|BloodCells|Volume(0.0813549284542636 [l])

Parameter: PBPK_model_human_Ab|Organism|Skin|BloodCells|Volume
	IsFixed: False
	Value: 0.0813549284542636 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|Skin|Fraction vascular(0.046)
		V: PBPK_model_human_Ab|Organism|Skin|Volume(3.76294766208435 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Skin|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Skin|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Skin|BloodCells|Volume(0.0813549284542636 [l])

Parameter: PBPK_model_human_Ab|Organism|Skin|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|Skin|Interstitial|Volume of protein container
	IsFixed: False
	Value: 1.13641019394947 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Skin|Interstitial|Volume(1.13641019394947 [l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Interstitial|Volume
	IsFixed: False
	Value: 1.13641019394947 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|Skin|Fraction interstitial(0.302)
		V: PBPK_model_human_Ab|Organism|Skin|Volume(3.76294766208435 [l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Skin|Interstitial|Volume(1.13641019394947 [l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Skin|Interstitial|Volume(1.13641019394947 [l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Intracellular|Volume of protein container
	IsFixed: False
	Value: 3.76294766208435 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Skin|Volume(3.76294766208435 [l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Intracellular|Volume
	IsFixed: False
	Value: 2.45344187567899 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|Skin|Fraction intracellular(0.652)
		V: PBPK_model_human_Ab|Organism|Skin|Volume(3.76294766208435 [l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Intracellular|pH
	IsFixed: False
	Value: 7
	Formula: 7

Parameter: PBPK_model_human_Ab|Organism|Skin|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Skin|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Skin|Intracellular|Volume(2.45344187567899 [l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.51789558967143
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|Partition coefficient (intracellular/water)(1.51789558967143)

Parameter: PBPK_model_human_Ab|Organism|Skin|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Endosome|Volume of protein container
	IsFixed: False
	Value: 0.000986644876998516 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Skin|Endosome|Volume(0.000986644876998516 [l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Endosome|Volume
	IsFixed: False
	Value: 0.000986644876998516 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|Skin|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)(1644.40812833086 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Skin|Endosome|Volume(0.000986644876998516 [l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Skin|Endosome|Volume(0.000986644876998516 [l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Spleen|Fraction endosomal
	IsFixed: False
	Value: 0.2
	Formula: f_endo_global
		f_endo_global: PBPK_model_human_Ab|Organism|Fraction endosomal (global)(0.2)

Parameter: PBPK_model_human_Ab|Organism|Spleen|Weight (tissue)
	IsFixed: False
	Value: 0.206924956693567 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|Spleen|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|Spleen|Volume(0.206924956693567 [l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|Spleen|Fluid recirculation flow rate
	IsFixed: False
	Value: 2.75110022586197E-07 [l/min]
	Formula: f_Jiso * (1-alpha_l) * Q_lymph * (V/V_mouse)^(exp_Jiso_scale - 1)
		alpha_l: PBPK_model_human_Ab|Organism|Spleen|Flow fraction via large pores(0.8)
		f_Jiso: PBPK_model_human_Ab|Organism|Spleen|Fluid recirculation flow proportionality factor(0.01)
		Q_lymph: PBPK_model_human_Ab|Organism|Spleen|Lymph flow rate(0.00174840525680567 [l/min])
		V_mouse: PBPK_model_human_Ab|Organism|Spleen|Organ volume mouse(0.0001 [l])
		V: PBPK_model_human_Ab|Organism|Spleen|Volume(0.206924956693567 [l])
		exp_Jiso_scale: PBPK_model_human_Ab|Organism|Scaling exponent for fluid recirculation flow rate(0.667)

Parameter: PBPK_model_human_Ab|Organism|Spleen|Lymph flow rate
	IsFixed: False
	Value: 0.00174840525680567 [l/min]
	Formula: f_lymph*Q*(1-HCT)
		Q: PBPK_model_human_Ab|Organism|Spleen|Blood flow rate(0.165772755931134 [l/min])
		f_lymph: PBPK_model_human_Ab|Organism|Spleen|Lymph flow proportionality factor(0.0199)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Spleen|Volume (endothelium)
	IsFixed: False
	Value: 0.001946129217703 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)(648.709739234333 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Fraction intracellular
	IsFixed: False
	Value: 0.52
	Formula: 1 - f_int - f_vas
		f_int: PBPK_model_human_Ab|Organism|Spleen|Fraction interstitial(0.15)
		f_vas: PBPK_model_human_Ab|Organism|Spleen|Fraction vascular(0.33)

Parameter: PBPK_model_human_Ab|Organism|Spleen|Blood flow rate
	IsFixed: False
	Value: 0.165772755931134 [l/min]
	Formula: Qspec * Weight
		Qspec: PBPK_model_human_Ab|Organism|Spleen|Specific blood flow rate(0.801125 [l/min/kg organ])
		Weight: PBPK_model_human_Ab|Organism|Spleen|Weight (tissue)(0.206924956693567 [kg])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Lymph flow proportionality factor
	IsFixed: False
	Value: 0.0199
	Formula: 0.0199

Parameter: PBPK_model_human_Ab|Organism|Spleen|Organ volume mouse
	IsFixed: False
	Value: 0.0001 [l]
	Formula: 0.0001

Parameter: PBPK_model_human_Ab|Organism|Spleen|Fluid recirculation flow proportionality factor
	IsFixed: False
	Value: 0.01
	Formula: 0.01

Parameter: PBPK_model_human_Ab|Organism|Spleen|Allometric scale factor
	IsFixed: False
	Value: 0.75
	Formula: 0.75

Parameter: PBPK_model_human_Ab|Organism|Spleen|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Spleen|Fraction of blood for sampling
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Spleen|Flow fraction via large pores
	IsFixed: False
	Value: 0.8
	Formula: 0.8

Parameter: PBPK_model_human_Ab|Organism|Spleen|Radius (small pores)
	IsFixed: False
	Value: 9E-08 [dm]
	Formula: 9E-08

Parameter: PBPK_model_human_Ab|Organism|Spleen|Hydraulic conductivity
	IsFixed: False
	Value: 3.88888888888889E-11 [l/min/(kg*dm/min²)]
	Formula: 3.88888888888889E-11

Parameter: PBPK_model_human_Ab|Organism|Spleen|Radius (large pores)
	IsFixed: False
	Value: 3.3E-07 [dm]
	Formula: 3.3E-07

Parameter: PBPK_model_human_Ab|Organism|Spleen|Vf (lipid)
	IsFixed: False
	Value: 0.016
	Formula: 0.016

Parameter: PBPK_model_human_Ab|Organism|Spleen|Vf (neutral lipid)-PT
	IsFixed: False
	Value: 0.0201
	Formula: 0.0201

Parameter: PBPK_model_human_Ab|Organism|Spleen|Vf (protein)
	IsFixed: False
	Value: 0.194
	Formula: 0.194

Parameter: PBPK_model_human_Ab|Organism|Spleen|Vf (phospholipid)-PT
	IsFixed: False
	Value: 0.0198
	Formula: 0.0198

Parameter: PBPK_model_human_Ab|Organism|Spleen|Fraction vascular
	IsFixed: False
	Value: 0.33
	Formula: 0.33

Parameter: PBPK_model_human_Ab|Organism|Spleen|Albumin ratio (tissue/plasma)
	IsFixed: False
	Value: 0.097
	Formula: 0.097

Parameter: PBPK_model_human_Ab|Organism|Spleen|Vf (water)-PT
	IsFixed: False
	Value: 0.788
	Formula: 0.788

Parameter: PBPK_model_human_Ab|Organism|Spleen|Vf (water)
	IsFixed: False
	Value: 0.778
	Formula: 0.778

Parameter: PBPK_model_human_Ab|Organism|Spleen|Albumin ratio (tissue/plasma)-PT
	IsFixed: False
	Value: 0.5
	Formula: 0.5

Parameter: PBPK_model_human_Ab|Organism|Spleen|Lipoprotein ratio (tissue/plasma)
	IsFixed: False
	Value: 0.207
	Formula: 0.207

Parameter: PBPK_model_human_Ab|Organism|Spleen|Fraction interstitial
	IsFixed: False
	Value: 0.15
	Formula: 0.15

Parameter: PBPK_model_human_Ab|Organism|Spleen|Vf (neutral lipid)-WS
	IsFixed: False
	Value: 0.006
	Formula: 0.006

Parameter: PBPK_model_human_Ab|Organism|Spleen|Vf (neutral lipid)-RR
	IsFixed: False
	Value: 0.0071
	Formula: 0.0071

Parameter: PBPK_model_human_Ab|Organism|Spleen|Vf (neutral phospholipid, plasma)-WS
	IsFixed: False
	Value: 0.0108
	Formula: 0.0108

Parameter: PBPK_model_human_Ab|Organism|Spleen|Vf (neutral phospholipid)-RR
	IsFixed: False
	Value: 0.0107
	Formula: 0.0107

Parameter: PBPK_model_human_Ab|Organism|Spleen|Vf (extracellular water)-RR
	IsFixed: False
	Value: 0.207
	Formula: 0.207

Parameter: PBPK_model_human_Ab|Organism|Spleen|Vf (protein)-WS
	IsFixed: False
	Value: 0.23
	Formula: 0.23

Parameter: PBPK_model_human_Ab|Organism|Spleen|Vf (intracellular water)-RR
	IsFixed: False
	Value: 0.355
	Formula: 0.355

Parameter: PBPK_model_human_Ab|Organism|Spleen|Vf (water)-WS
	IsFixed: False
	Value: 0.75
	Formula: 0.75

Parameter: PBPK_model_human_Ab|Organism|Spleen|Vf (acidic phospholipids)-WS
	IsFixed: False
	Value: 0.003
	Formula: 0.003

Parameter: PBPK_model_human_Ab|Organism|Spleen|Acidic phospholipids [mg/g] - RR
	IsFixed: False
	Value: 3.18
	Formula: 3.18

Parameter: PBPK_model_human_Ab|Organism|Spleen|Volume
	IsFixed: False
	Value: 0.206924956693567 [l]
	Percentile: 0.344385294678753

Parameter: PBPK_model_human_Ab|Organism|Spleen|Specific blood flow rate
	IsFixed: False
	Value: 0.801125 [l/min/kg organ]
	Percentile: 0.5

Parameter: PBPK_model_human_Ab|Organism|Spleen|Plasma|Volume of protein container
	IsFixed: False
	Value: 0.0361911749257049 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Spleen|Plasma|Volume(0.0361911749257049 [l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Plasma|FcRn concentration in container
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration(0.737391752667387 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Plasma|Volume
	IsFixed: False
	Value: 0.0361911749257049 [l]
	Formula: f_vas*(1-HCT)*V_org
		f_vas: PBPK_model_human_Ab|Organism|Spleen|Fraction vascular(0.33)
		V_org: PBPK_model_human_Ab|Organism|Spleen|Volume(0.206924956693567 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Spleen|Plasma|Volume(0.0361911749257049 [l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Spleen|Plasma|Volume(0.0361911749257049 [l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|BloodCells|Volume of protein container
	IsFixed: False
	Value: 0.0320940607831723 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Spleen|BloodCells|Volume(0.0320940607831723 [l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|BloodCells|Volume
	IsFixed: False
	Value: 0.0320940607831723 [l]
	Formula: f_vas*HCT*V
		f_vas: PBPK_model_human_Ab|Organism|Spleen|Fraction vascular(0.33)
		V: PBPK_model_human_Ab|Organism|Spleen|Volume(0.206924956693567 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Organism|Spleen|BloodCells|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Spleen|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Spleen|BloodCells|Volume(0.0320940607831723 [l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|BloodCells|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 0.677819142596308
	Formula: K_rbc/fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_rbc: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)(0.677819142596308)

Parameter: PBPK_model_human_Ab|Organism|Spleen|Interstitial|Volume of protein container
	IsFixed: False
	Value: 0.0310387435040351 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Spleen|Interstitial|Volume(0.0310387435040351 [l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Interstitial|FcRn concentration in container
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration(0 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Interstitial|Volume
	IsFixed: False
	Value: 0.0310387435040351 [l]
	Formula: f_int*V
		f_int: PBPK_model_human_Ab|Organism|Spleen|Fraction interstitial(0.15)
		V: PBPK_model_human_Ab|Organism|Spleen|Volume(0.206924956693567 [l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Spleen|Interstitial|Volume(0.0310387435040351 [l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial(999999 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.03909058791745
	Formula: K_water_int
		K_water_int: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|Partition coefficient (interstitial/water)(1.03909058791745)

Parameter: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Spleen|Interstitial|Volume(0.0310387435040351 [l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Intracellular|Volume of protein container
	IsFixed: False
	Value: 0.206924956693567 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Spleen|Volume(0.206924956693567 [l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Intracellular|Volume
	IsFixed: False
	Value: 0.107600977480655 [l]
	Formula: f_cell*V
		f_cell: PBPK_model_human_Ab|Organism|Spleen|Fraction intracellular(0.52)
		V: PBPK_model_human_Ab|Organism|Spleen|Volume(0.206924956693567 [l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Intracellular|pH
	IsFixed: False
	Value: 7
	Formula: 7

Parameter: PBPK_model_human_Ab|Organism|Spleen|Intracellular|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Spleen|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Spleen|Intracellular|Volume(0.107600977480655 [l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Intracellular|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1.23528605190271
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|Partition coefficient (intracellular/water)(1.23528605190271)

Parameter: PBPK_model_human_Ab|Organism|Spleen|Endosome|Volume of protein container
	IsFixed: False
	Value: 0.0003892258435406 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|Spleen|Endosome|Volume(0.0003892258435406 [l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Endosome|FcRn concentration in container
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: FcRn
		FcRn: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration(80.8 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Endosome|Volume
	IsFixed: False
	Value: 0.0003892258435406 [l]
	Formula: f_endo*SA_pls_int*d_endo
		f_endo: PBPK_model_human_Ab|Organism|Spleen|Fraction endosomal(0.2)
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)(648.709739234333 [dm²])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Spleen|Endosome|Volume(0.0003892258435406 [l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1|Partition coefficient (water/container)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1|Kd (FcRn) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn
		Kd_FcRn: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1-FcRn_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1-FcRn_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Spleen|Endosome|Volume(0.0003892258435406 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|krpls
	IsFixed: False
	Value: 0.490062317574971 [l/min]
	Formula: f_mem_pls* f_uptake_vas * K_uptake * V_end
		f_mem_pls: PBPK_model_human_Ab|Organism|EndogenousIgG|f_membrane_pls(92.9824561403509)
		f_uptake_vas: PBPK_model_human_Ab|Organism|EndogenousIgG|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|EndogenousIgG|Rate constant for endosomal uptake(0.294 [1/min])
		V_end: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|krint
	IsFixed: False
	Value: 0 [l/min]
	Formula: f_mem_int* (1- f_uptake_vas)* K_uptake * V_end
		f_mem_int: PBPK_model_human_Ab|Organism|EndogenousIgG|f_membrane_int(608.420708380725)
		f_uptake_vas: PBPK_model_human_Ab|Organism|EndogenousIgG|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|EndogenousIgG|Rate constant for endosomal uptake(0.294 [1/min])
		V_end: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|f_membrane_int
	IsFixed: False
	Value: 608.420708380725
	Formula: Volume_EndogenIgG_int / Volume_EndogenIgG_endosom
		Volume_EndogenIgG_endosom: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])
		Volume_EndogenIgG_int: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|Volume(10.9070411740154 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|f_membrane_pls
	IsFixed: False
	Value: 92.9824561403509
	Formula: Volume_EndogenIgG_pls / Volume_EndogenIgG_endosom
		Volume_EndogenIgG_endosom: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])
		Volume_EndogenIgG_pls: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Volume(1.66687863120739 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Fraction of endosomal uptake from plasma
	IsFixed: False
	Value: 1
	Formula: f_uptake_vas_global
		f_uptake_vas_global: PBPK_model_human_Ab|Organism|Fraction of endosomal uptake from plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e_endog) : 1e-22
		alpha_l: PBPK_model_human_Ab|Organism|EndogenousIgG|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|EndogenousIgG|Hydraulic conductivity(1.84722E-11 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius (small pores)(4.5E-08 [dm])
		gamma: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius ratio (solute/small pores)(1.18666666666667)
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])
		a_e_endog: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius (endogeneous IgG)(5.34E-08 [dm])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|P (large endothelial pores)
	IsFixed: False
	Value: 6.37361108653678E-08 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e_endog) : 1e-22
		alpha_l: PBPK_model_human_Ab|Organism|EndogenousIgG|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|EndogenousIgG|Hydraulic conductivity(1.84722E-11 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius (large pores)(2.5E-07 [dm])
		gamma: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius ratio (solute/large pores)(0.2136)
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])
		a_e_endog: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius (endogeneous IgG)(5.34E-08 [dm])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kpe
	IsFixed: False
	Value: 0.00527048152863649 [l/min]
	Formula: f_uptake_vas*K_uptake*V_end
		f_uptake_vas: PBPK_model_human_Ab|Organism|EndogenousIgG|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|EndogenousIgG|Rate constant for endosomal uptake(0.294 [1/min])
		V_end: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kin
	IsFixed: False
	Value: 0.00756579573170419 [µmol/min]
	Formula: Cpl*kdeg*(k_diff_pls*kei*kie+k_diff_pls*Kd*ka*Ve*kie+k_diff_pls*kep*kie+k_conv*kei*kie+k_conv*Kd*ka*Ve*kie+k_conv*kep*kie+kpe*kep*kie+kpe*kep*k_diff_int+kpe*kep*Ql+kpe*Kd*ka*Ve*Ql+kpe*kei*k_diff_int+kpe*kei*Ql+kpe*Kd*ka*Ve*kie+kpe*Kd*ka*Ve*k_diff_int+kpe*kei*kie)/(kdeg*kep*Ql+kdeg*kep*kie+kdeg*kep*k_diff_int+ka*FcRnEnd*Ve*kei*Ql+ka*FcRnEnd*Ve*kei*k_diff_int+ka*FcRnEnd*Ve*kep*Ql+ka*FcRnEnd*Ve*kep*kie+ka*FcRnEnd*Ve*kep*k_diff_int+kdeg*Kd*ka*Ve*Ql+kdeg*Kd*ka*Ve*kie+kdeg*Kd*ka*Ve*k_diff_int+kdeg*kei*Ql+kdeg*kei*kie+kdeg*kei*k_diff_int)
		k_conv: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_conv(0.000799102869318376 [l/min])
		k_diff_int: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_int(0.00152160685833196 [l/min])
		k_diff_pls: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_pls(0.00152160685833196 [l/min])
		kdeg: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kdeg(0.00367858098529322 [l/min])
		kei: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kei(0 [l/min])
		kep: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kep(0.00159190054334327 [l/min])
		kie: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kie(0 [l/min])
		kpe: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kpe(0.00527048152863649 [l/min])
		ka: PBPK_model_human_Ab|Organism|EndogenousIgG|kass (FcRn, endogenous IgG)(0.87 [l/µmol/min])
		Kd: PBPK_model_human_Ab|Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in endosomal space(0.63 [µmol/l])
		Ql: PBPK_model_human_Ab|Organism|EndogenousIgG|Lymph flow rate(0.0140728079701645 [l/min])
		Ve: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])
		FcRnEnd: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Start concentration of free FcRn (endosome)(80.8 [µmol/l])
		Cpl: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Start concentration of free endogenous IgG (plasma)(70 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Peclet number (large pores)
	IsFixed: False
	Value: 0.416435454772092
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		alpha_l: PBPK_model_human_Ab|Organism|EndogenousIgG|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|EndogenousIgG|Fluid recirculation flow rate(0.000246405447880628 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|EndogenousIgG|Lymph flow rate(0.0140728079701645 [l/min])
		P_endothelial_l: PBPK_model_human_Ab|Organism|EndogenousIgG|P (large endothelial pores)(6.37361108653678E-08 [dm/min])
		sigma_l: PBPK_model_human_Ab|Organism|EndogenousIgG|Reflection coefficient (large pores)(0.172692444072958)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_int_EndogenousIgG_pls|Surface area (plasma/interstitial)(29612.719787982 [dm²])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Rate constant for recycling from endosomal space
	IsFixed: False
	Value: 0.0888 [1/min]
	Formula: Rrec_global
		Rrec_global: PBPK_model_human_Ab|Organism|Rate constant for recycling from endosomal space (global)(0.0888 [1/min])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Rate constant for endosomal uptake
	IsFixed: False
	Value: 0.294 [1/min]
	Formula: Rendo_v_global
		Rendo_v_global: PBPK_model_human_Ab|Organism|Rate constant for endosomal uptake (global)(0.294 [1/min])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e_endog / r_s
		r_s: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius (small pores)(4.5E-08 [dm])
		a_e_endog: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius (endogeneous IgG)(5.34E-08 [dm])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e_endog / r_l
		r_l: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius (large pores)(2.5E-07 [dm])
		a_e_endog: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius (endogeneous IgG)(5.34E-08 [dm])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Peclet number (small pores)
	IsFixed: False
	Value: 4431461283438.54
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		alpha_l: PBPK_model_human_Ab|Organism|EndogenousIgG|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|EndogenousIgG|Fluid recirculation flow rate(0.000246405447880628 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|EndogenousIgG|Lymph flow rate(0.0140728079701645 [l/min])
		P_endothelial_s: PBPK_model_human_Ab|Organism|EndogenousIgG|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Organism|EndogenousIgG|Reflection coefficient (small pores)(0.999)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_int_EndogenousIgG_pls|Surface area (plasma/interstitial)(29612.719787982 [dm²])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kdeg
	IsFixed: False
	Value: 0.00367858098529322 [l/min]
	Formula: CLspec*V_end
		CLspec: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Specific endosomal clearance(0.2052 [1/min])
		V_end: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kie
	IsFixed: False
	Value: 0 [l/min]
	Formula: (1-f_uptake_vas)*K_uptake*V_end
		f_uptake_vas: PBPK_model_human_Ab|Organism|EndogenousIgG|Fraction of endosomal uptake from plasma(1)
		K_uptake: PBPK_model_human_Ab|Organism|EndogenousIgG|Rate constant for endosomal uptake(0.294 [1/min])
		V_end: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kep
	IsFixed: False
	Value: 0.00159190054334327 [l/min]
	Formula: f_rec_vas*K_rec*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|EndogenousIgG|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|EndogenousIgG|Rate constant for recycling from endosomal space(0.0888 [1/min])
		V_end: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kei
	IsFixed: False
	Value: 0 [l/min]
	Formula: (1-f_rec_vas)*K_rec*V_end
		f_rec_vas: PBPK_model_human_Ab|Organism|EndogenousIgG|Fraction recycled to plasma(1)
		K_rec: PBPK_model_human_Ab|Organism|EndogenousIgG|Rate constant for recycling from endosomal space(0.0888 [1/min])
		V_end: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_pls
	IsFixed: False
	Value: 0.00152160685833196 [l/min]
	Formula: P_endothelial_l*SA_pls_int*Pe_l/(exp(Pe_l)-1) + P_endothelial_s*SA_pls_int*Pe_s/(exp(Pe_s)-1)
		P_endothelial_l: PBPK_model_human_Ab|Organism|EndogenousIgG|P (large endothelial pores)(6.37361108653678E-08 [dm/min])
		P_endothelial_s: PBPK_model_human_Ab|Organism|EndogenousIgG|P (small endothelial pores)(1E-22 [dm/min])
		Pe_l: PBPK_model_human_Ab|Organism|EndogenousIgG|Peclet number (large pores)(0.416435454772092)
		Pe_s: PBPK_model_human_Ab|Organism|EndogenousIgG|Peclet number (small pores)(4431461283438.54)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_int_EndogenousIgG_pls|Surface area (plasma/interstitial)(29612.719787982 [dm²])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_int
	IsFixed: False
	Value: 0.00152160685833196 [l/min]
	Formula: k_diff_pls
		k_diff_pls: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_pls(0.00152160685833196 [l/min])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_conv
	IsFixed: False
	Value: 0.000799102869318376 [l/min]
	Formula: (J_iso + alpha_l*Q_lymph)*(1-sigma_l) + (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)
		alpha_l: PBPK_model_human_Ab|Organism|EndogenousIgG|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|EndogenousIgG|Fluid recirculation flow rate(0.000246405447880628 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|EndogenousIgG|Lymph flow rate(0.0140728079701645 [l/min])
		sigma_l: PBPK_model_human_Ab|Organism|EndogenousIgG|Reflection coefficient (large pores)(0.172692444072958)
		sigma_s: PBPK_model_human_Ab|Organism|EndogenousIgG|Reflection coefficient (small pores)(0.999)

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Fraction recycled to plasma
	IsFixed: False
	Value: 1
	Formula: f_rec_vas_global
		f_rec_vas_global: PBPK_model_human_Ab|Organism|Fraction recycled to plasma (global)(1)

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in plasma/interstitial
	IsFixed: False
	Value: 10000 [µmol/l]
	Formula: 10000

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|kass (FcRn, endogenous IgG)
	IsFixed: False
	Value: 0.87 [l/µmol/min]
	Formula: 0.87

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Lymph flow rate
	IsFixed: False
	Value: 0.0140728079701645 [l/min]
	Formula: Q_lymph_bon+Q_lymph_brn+Q_lymph_fat+Q_lymph_tes+Q_lymph_hrt+Q_lymph_kid+Q_lymph_lin+Q_lymph_liv+Q_lymph_lng+Q_lymph_mus+Q_lymph_pan+Q_lymph_skn+Q_lymph_sin+Q_lymph_spl+Q_lymph_sto
		Q_lymph_bon: PBPK_model_human_Ab|Organism|Bone|Lymph flow rate(0.000114014111293118 [l/min])
		Q_lymph_brn: PBPK_model_human_Ab|Organism|Brain|Lymph flow rate(3.00487703953774E-05 [l/min])
		Q_lymph_fat: PBPK_model_human_Ab|Organism|Fat|Lymph flow rate(0.00127932693260599 [l/min])
		Q_lymph_tes: PBPK_model_human_Ab|Organism|Gonads|Lymph flow rate(1.90943705999462E-05 [l/min])
		Q_lymph_hrt: PBPK_model_human_Ab|Organism|Heart|Lymph flow rate(0.000202809065392218 [l/min])
		Q_lymph_kid: PBPK_model_human_Ab|Organism|Kidney|Lymph flow rate(0.000498718147553631 [l/min])
		Q_lymph_lin: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate (incl. mucosa)(0.00198485331204306 [l/min])
		Q_lymph_liv: PBPK_model_human_Ab|Organism|Liver|Lymph flow rate(0.00449682523507667 [l/min])
		Q_lymph_lng: PBPK_model_human_Ab|Organism|Lung|Lymph flow rate(0.000114900141047345 [l/min])
		Q_lymph_mus: PBPK_model_human_Ab|Organism|Muscle|Lymph flow rate(0.00118884232037053 [l/min])
		Q_lymph_pan: PBPK_model_human_Ab|Organism|Pancreas|Lymph flow rate(0.0010456145699991 [l/min])
		Q_lymph_skn: PBPK_model_human_Ab|Organism|Skin|Lymph flow rate(0.000606892413442345 [l/min])
		Q_lymph_sin: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow rate (incl. mucosa)(0.000672104223100808 [l/min])
		Q_lymph_spl: PBPK_model_human_Ab|Organism|Spleen|Lymph flow rate(0.00174840525680567 [l/min])
		Q_lymph_sto: PBPK_model_human_Ab|Organism|Stomach|Lymph flow rate(7.03591004386913E-05 [l/min])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Volume (endothelium)
	IsFixed: False
	Value: 0.088838159363946 [l]
	Formula: SA_pls_int*d_endo
		d_endo: PBPK_model_human_Ab|Organism|Thickness (endothelium)(3E-06 [dm])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_int_EndogenousIgG_pls|Surface area (plasma/interstitial)(29612.719787982 [dm²])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Fluid recirculation flow rate
	IsFixed: False
	Value: 0.000246405447880628 [l/min]
	Formula: J_iso_bon+J_iso_brn+J_iso_fat+J_iso_tes+J_iso_hrt+J_iso_kid+J_iso_lin+J_iso_liv+J_iso_lng+J_iso_mus+J_iso_pan+J_iso_skn+J_iso_sin+J_iso_spl+J_iso_sto
		J_iso_bon: PBPK_model_human_Ab|Organism|Bone|Fluid recirculation flow rate(5.33261345230804E-06 [l/min])
		J_iso_brn: PBPK_model_human_Ab|Organism|Brain|Fluid recirculation flow rate(5.58665816421524E-07 [l/min])
		J_iso_fat: PBPK_model_human_Ab|Organism|Fat|Fluid recirculation flow rate(1.77855852400894E-05 [l/min])
		J_iso_tes: PBPK_model_human_Ab|Organism|Gonads|Fluid recirculation flow rate(3.20596453218297E-06 [l/min])
		J_iso_hrt: PBPK_model_human_Ab|Organism|Heart|Fluid recirculation flow rate(1.13227091465884E-05 [l/min])
		J_iso_kid: PBPK_model_human_Ab|Organism|Kidney|Fluid recirculation flow rate(3.32038716868045E-05 [l/min])
		J_iso_lin: PBPK_model_human_Ab|Organism|LargeIntestine|Fluid recirculation flow rate (incl. mucosa)(3.09817248650303E-05 [l/min])
		J_iso_liv: PBPK_model_human_Ab|Organism|Liver|Fluid recirculation flow rate(7.07876482920826E-05 [l/min])
		J_iso_lng: PBPK_model_human_Ab|Organism|Lung|Fluid recirculation flow rate(4.76380931227607E-08 [l/min])
		J_iso_mus: PBPK_model_human_Ab|Organism|Muscle|Fluid recirculation flow rate(2.2292095155886E-05 [l/min])
		J_iso_pan: PBPK_model_human_Ab|Organism|Pancreas|Fluid recirculation flow rate(8.76759089031544E-07 [l/min])
		J_iso_skn: PBPK_model_human_Ab|Organism|Skin|Fluid recirculation flow rate(3.26924996641784E-05 [l/min])
		J_iso_sin: PBPK_model_human_Ab|Organism|SmallIntestine|Fluid recirculation flow rate (incl. mucosa)(1.14629640224353E-05 [l/min])
		J_iso_spl: PBPK_model_human_Ab|Organism|Spleen|Fluid recirculation flow rate(2.75110022586197E-07 [l/min])
		J_iso_sto: PBPK_model_human_Ab|Organism|Stomach|Fluid recirculation flow rate(5.57959880187978E-06 [l/min])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in endosomal space
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: 0.63

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius (endogeneous IgG)
	IsFixed: False
	Value: 5.34E-08 [dm]
	Formula: 5.34E-08

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Flow fraction via large pores
	IsFixed: False
	Value: 0.05
	Formula: 0.05

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius (small pores)
	IsFixed: False
	Value: 4.5E-08 [dm]
	Formula: 4.5E-08

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Hydraulic conductivity
	IsFixed: False
	Value: 1.84722E-11 [l/min/(kg*dm/min²)]
	Formula: 1.84722E-11

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Radius (large pores)
	IsFixed: False
	Value: 2.5E-07 [dm]
	Formula: 2.5E-07

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Volume of protein container
	IsFixed: False
	Value: 1.66687863120739 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Volume(1.66687863120739 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Kd (FcRn, endogenous IgG) in endosomal space of container
	IsFixed: False
	Value: 10000 [µmol/l]
	Formula: Kd_FcRn_LigandEndo
		Kd_FcRn_LigandEndo: PBPK_model_human_Ab|Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in plasma/interstitial(10000 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Volume
	IsFixed: False
	Value: 1.66687863120739 [l]
	Formula: V_bon+V_brn+V_fat+V_tes+V_hrt+V_kid+V_lin+V_liv+V_lng+V_mus+V_pan+V_skn+V_sin+V_spl+V_sto+V_duo+V_uje+V_lje+V_uil+V_lil+V_cae+V_colasc+V_coltrans+V_coldesc+V_colsigm+V_rect
		V_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|Volume(0.000457394928820579 [l])
		V_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Volume(0.00083855740550307 [l])
		V_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Volume(0.000881457458163453 [l])
		V_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Volume(0.000708314028881347 [l])
		V_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Volume(0.00176291491632691 [l])
		V_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Volume(0.001129096160459 [l])
		V_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Volume(0.00101229310937703 [l])
		V_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Volume(0.00238797348878684 [l])
		V_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|Volume(0.000288572382136845 [l])
		V_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Volume(0.00210245491947537 [l])
		V_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Volume(0.00323155107993437 [l])
		V_bon: PBPK_model_human_Ab|Organism|Bone|Plasma|Volume(0.21297361860168 [l])
		V_brn: PBPK_model_human_Ab|Organism|Brain|Plasma|Volume(0.0311943841534115 [l])
		V_fat: PBPK_model_human_Ab|Organism|Fat|Plasma|Volume(0.139839566189771 [l])
		V_tes: PBPK_model_human_Ab|Organism|Gonads|Plasma|Volume(0.00117384300516067 [l])
		V_hrt: PBPK_model_human_Ab|Organism|Heart|Plasma|Volume(0.0309860416860081 [l])
		V_kid: PBPK_model_human_Ab|Organism|Kidney|Plasma|Volume(0.0534462425234655 [l])
		V_lin: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|Volume(0.00417957744745837 [l])
		V_liv: PBPK_model_human_Ab|Organism|Liver|Plasma|Volume(0.214130936164388 [l])
		V_lng: PBPK_model_human_Ab|Organism|Lung|Plasma|Volume(0.373299674376007 [l])
		V_mus: PBPK_model_human_Ab|Organism|Muscle|Plasma|Volume(0.432483065940599 [l])
		V_pan: PBPK_model_human_Ab|Organism|Pancreas|Plasma|Volume(0.0201864473139155 [l])
		V_skn: PBPK_model_human_Ab|Organism|Skin|Plasma|Volume(0.0917406640016164 [l])
		V_sin: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|Volume(0.00739430123772535 [l])
		V_spl: PBPK_model_human_Ab|Organism|Spleen|Plasma|Volume(0.0361911749257049 [l])
		V_sto: PBPK_model_human_Ab|Organism|Stomach|Plasma|Volume(0.00285851376261118 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Start concentration of free endogenous IgG (plasma)
	IsFixed: False
	Value: 70 [µmol/l]
	Formula: 70

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo|Concentration
	IsFixed: False
	Value: 70 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo(116.681504184517 [µmol])
		V: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Volume(1.66687863120739 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn|Concentration
	IsFixed: False
	Value: 0.737391752667387 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn(1.22914255534983 [µmol])
		V: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Volume(1.66687863120739 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo_Complex|Concentration
	IsFixed: False
	Value: 0.0051866610244515 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo_Complex(0.00864553442897442 [µmol])
		V: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Volume(1.66687863120739 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn kinetics plasma|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn kinetics plasma(0 [µmol])
		V: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Volume(1.66687863120739 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|Kd (FcRn, endogenous IgG) in endosomal space of container
	IsFixed: False
	Value: 10000 [µmol/l]
	Formula: Kd_FcRn_LigandEndo
		Kd_FcRn_LigandEndo: PBPK_model_human_Ab|Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in plasma/interstitial(10000 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|Volume of protein container
	IsFixed: False
	Value: 10.9070411740154 [l]
	Formula: Volume
		Volume: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|Volume(10.9070411740154 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|Volume
	IsFixed: False
	Value: 10.9070411740154 [l]
	Formula: V_bon+V_brn+V_fat+V_tes+V_hrt+V_kid+V_lin+V_liv+V_lng+V_mus+V_pan+V_skn+V_sin+V_spl+V_sto+V_duo+V_uje+V_lje+V_uil+V_lil+V_cae+V_colasc+V_coltrans+V_coldesc+V_colsigm+V_rect
		V_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume(0.00484612914425286 [l])
		V_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume(0.00888457047920524 [l])
		V_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume(0.0102559515572477 [l])
		V_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume(0.0130303052482889 [l])
		V_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume(0.0205119031144955 [l])
		V_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume(0.00688273421469925 [l])
		V_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume(0.00470150645864514 [l])
		V_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume(0.0110907331844962 [l])
		V_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume(0.00469610716213262 [l])
		V_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume(0.00945952140837976 [l])
		V_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume(0.0164157166614953 [l])
		V_bon: PBPK_model_human_Ab|Organism|Bone|Interstitial|Volume(1.18187357714584 [l])
		V_brn: PBPK_model_human_Ab|Organism|Brain|Interstitial|Volume(0.00603664908629153 [l])
		V_fat: PBPK_model_human_Ab|Organism|Fat|Interstitial|Volume(2.34531767194584 [l])
		V_tes: PBPK_model_human_Ab|Organism|Gonads|Interstitial|Volume(0.00277856491787602 [l])
		V_hrt: PBPK_model_human_Ab|Organism|Heart|Interstitial|Volume(0.0417601639973155 [l])
		V_kid: PBPK_model_human_Ab|Organism|Kidney|Interstitial|Volume(0.0876886669786144 [l])
		V_lin: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|Volume(0.0308868144702113 [l])
		V_liv: PBPK_model_human_Ab|Organism|Liver|Interstitial|Volume(0.387384490508271 [l])
		V_lng: PBPK_model_human_Ab|Organism|Lung|Interstitial|Volume(0.228302988883179 [l])
		V_mus: PBPK_model_human_Ab|Organism|Muscle|Interstitial|Volume(5.22243702267893 [l])
		V_pan: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|Volume(0.02285258186481 [l])
		V_skn: PBPK_model_human_Ab|Organism|Skin|Interstitial|Volume(1.13641019394947 [l])
		V_sin: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|Volume(0.054643421096398 [l])
		V_spl: PBPK_model_human_Ab|Organism|Spleen|Interstitial|Volume(0.0310387435040351 [l])
		V_sto: PBPK_model_human_Ab|Organism|Stomach|Interstitial|Volume(0.0168544443550188 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|pH
	IsFixed: False
	Value: 7.4
	Formula: pH_int
		pH_int: PBPK_model_human_Ab|Organism|pH (interstitial)(7.4)

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo|Concentration
	IsFixed: False
	Value: 10.4171706807922 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo(113.620509532146 [µmol])
		V: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|Volume(10.9070411740154 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn(0 [µmol])
		V: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|Volume(10.9070411740154 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo_Complex|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo_Complex(0 [µmol])
		V: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|Volume(10.9070411740154 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn kinetics interstitial|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn kinetics interstitial(0 [µmol])
		V: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|Volume(10.9070411740154 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Specific endosomal clearance
	IsFixed: False
	Value: 0.2052 [1/min]
	Formula: CLspec_endosomal_global
		CLspec_endosomal_global: PBPK_model_human_Ab|Organism|Specific clearance (endosome)(0.2052 [1/min])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Kd (FcRn, endogenous IgG) in endosomal space of container
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: Kd_FcRn_LigandEndo
		Kd_FcRn_LigandEndo: PBPK_model_human_Ab|Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in endosomal space(0.63 [µmol/l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume
	IsFixed: False
	Value: 0.0179268079205323 [l]
	Formula: V_bon+V_brn+V_fat+V_tes+V_hrt+V_kid+V_lin+V_liv+V_lng+V_mus+V_pan+V_skn+V_sin+V_spl+V_sto+V_duo+V_uje+V_lje+V_uil+V_lil+V_cae+V_colasc+V_coltrans+V_coldesc+V_colsigm+V_rect
		V_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume(4.91915300807037E-06 [l])
		V_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume(9.01844756861792E-06 [l])
		V_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume(9.47982549345601E-06 [l])
		V_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume(7.61771691438429E-06 [l])
		V_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume(1.8959650986912E-05 [l])
		V_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume(1.21431096502194E-05 [l])
		V_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume(1.08869258933002E-05 [l])
		V_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume(2.56819790303491E-05 [l])
		V_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume(3.10351429845286E-06 [l])
		V_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume(2.26113076245465E-05 [l])
		V_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume(3.47544172747659E-05 [l])
		V_bon: PBPK_model_human_Ab|Organism|Bone|Endosome|Volume(0.00229047099250863 [l])
		V_brn: PBPK_model_human_Ab|Organism|Brain|Endosome|Volume(0.000335486772970652 [l])
		V_fat: PBPK_model_human_Ab|Organism|Fat|Endosome|Volume(0.00150393495713527 [l])
		V_tes: PBPK_model_human_Ab|Organism|Gonads|Endosome|Volume(1.26243493007845E-05 [l])
		V_hrt: PBPK_model_human_Ab|Organism|Heart|Endosome|Volume(0.000333246108698578 [l])
		V_kid: PBPK_model_human_Ab|Organism|Kidney|Endosome|Volume(0.000574799212044817 [l])
		V_lin: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|Volume(4.49501725481372E-05 [l])
		V_liv: PBPK_model_human_Ab|Organism|Liver|Endosome|Volume(0.00230291761535285 [l])
		V_lng: PBPK_model_human_Ab|Organism|Lung|Endosome|Volume(0.00401473234706272 [l])
		V_mus: PBPK_model_human_Ab|Organism|Muscle|Endosome|Volume(0.00465123297332342 [l])
		V_pan: PBPK_model_human_Ab|Organism|Pancreas|Endosome|Volume(0.000217099527715695 [l])
		V_skn: PBPK_model_human_Ab|Organism|Skin|Endosome|Volume(0.000986644876998516 [l])
		V_sin: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|Volume(7.95236170849708E-05 [l])
		V_spl: PBPK_model_human_Ab|Organism|Spleen|Endosome|Volume(0.0003892258435406 [l])
		V_sto: PBPK_model_human_Ab|Organism|Stomach|Endosome|Volume(3.07425065035542E-05 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Start concentration of free FcRn (endosome)
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: 80.8

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo|Concentration
	IsFixed: False
	Value: 2.05671582655156 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo(0.0368703495697085 [µmol])
		V: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn|Concentration
	IsFixed: False
	Value: 80.8 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn(1.44848607997901 [µmol])
		V: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn kinetics endosome|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn kinetics endosome(0 [µmol])
		V: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo_Complex|Concentration
	IsFixed: False
	Value: 227.004075589996 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo_Complex(4.06945846027984 [µmol])
		V: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_Source|Volume
	IsFixed: False
	Value: 1 [l]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_Source|LigandEndo|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_Source|LigandEndo(0 [µmol])
		V: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_Source|Volume(1 [l])

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|EndosomalClearance|Volume
	IsFixed: False
	Value: 1 [l]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|EndogenousIgG|EndosomalClearance|LigandEndo|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|EndogenousIgG|EndosomalClearance|LigandEndo(0 [µmol])
		V: PBPK_model_human_Ab|Organism|EndogenousIgG|EndosomalClearance|Volume(1 [l])

Parameter: PBPK_model_human_Ab|Organism|Saliva|Weight (tissue)
	IsFixed: False
	Value: 0.00600000000845946 [kg]
	Formula: Volume * Density
		Density: PBPK_model_human_Ab|Organism|Saliva|Density (tissue)(1 [kg/dm³])
		Volume: PBPK_model_human_Ab|Organism|Saliva|Volume(0.00600000000845946 [l])

Parameter: PBPK_model_human_Ab|Organism|Saliva|Volume
	IsFixed: False
	Value: 0.00600000000845946 [l]
	Formula: 0.006 * BW / 73
		BW: PBPK_model_human_Ab|Organism|Weight(73.0000001029235 [kg])

Parameter: PBPK_model_human_Ab|Organism|Saliva|Saliva flow rate
	IsFixed: False
	Value: 0.001 [l/min]
	Formula: 0.001

Parameter: PBPK_model_human_Ab|Organism|Saliva|Density (tissue)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|Saliva|Saliva|Volume
	IsFixed: False
	Value: 0.00600000000845946 [l]
	Formula: V_slv
		V_slv: PBPK_model_human_Ab|Organism|Saliva|Volume(0.00600000000845946 [l])

Parameter: PBPK_model_human_Ab|Organism|Saliva|Saliva|pH (saliva)
	IsFixed: False
	Value: 7.4
	Formula: 7.4

Parameter: PBPK_model_human_Ab|Organism|Saliva|Saliva|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Saliva|Saliva|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Saliva|Saliva|Volume(0.00600000000845946 [l])

Parameter: PBPK_model_human_Ab|Organism|Saliva|SalivaGland|Volume
	IsFixed: False
	Value: 0.00600000000845946 [l]
	Formula: V_slv
		V_slv: PBPK_model_human_Ab|Organism|Saliva|Volume(0.00600000000845946 [l])

Parameter: PBPK_model_human_Ab|Organism|Saliva|SalivaGland|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Saliva|SalivaGland|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Saliva|SalivaGland|Volume(0.00600000000845946 [l])

Parameter: PBPK_model_human_Ab|Organism|EndosomalClearance|Volume
	IsFixed: False
	Value: 1 [l]
	Formula: 1

Parameter: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1|Concentration
	IsFixed: False
	Value: 0 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|EndosomalClearance|Volume(1 [l])

Parameter: PBPK_model_human_Ab|Neighborhoods|VenousBlood_pls_VenousBlood_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 45398.077535931 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V
		V: PBPK_model_human_Ab|Organism|VenousBlood|Volume(0.963988566185309 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_ArterialBlood_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 19738.1072965671 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V
		V: PBPK_model_human_Ab|Organism|ArterialBlood|Volume(0.419121486740713 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 18924.1124423161 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|Bone|Fraction vascular(0.034)
		V: PBPK_model_human_Ab|Organism|Bone|Volume(11.8187357714584 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 92627.8185575828 [dm²]
	Formula: (V_bon * 1000 / 28.2)^0.75 * 10 * 1E2
		V_bon: PBPK_model_human_Ab|Organism|Bone|Volume(11.8187357714584 [l])

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|P_int_cell_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|Surface area (interstitial/intracellular)(92627.8185575828 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|P_cell_int_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.50855811635634
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|Bone|Vf (lipid)(0.268)
		f_proteins: PBPK_model_human_Ab|Organism|Bone|Vf (protein)(0.268)
		f_water: PBPK_model_human_Ab|Organism|Bone|Vf (water)(0.465)

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.96634360525929
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|Partition coefficient (intracellular/plasma)(0.50855811635634)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|Surface area (interstitial/intracellular)(92627.8185575828 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 3817.45165418105 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|Bone|Fraction vascular(0.034)
		V_org: PBPK_model_human_Ab|Organism|Bone|Volume(11.8187357714584 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 269763186557.621
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|Bone|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Bone|Fluid recirculation flow rate(5.33261345230804E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Bone|Lymph flow rate(0.000114014111293118 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)(3817.45165418105 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 3.10534206964146E-08 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Bone|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Bone|Hydraulic conductivity(9E-12 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Bone|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Bone|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Bone|Hydraulic conductivity(9E-12 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Bone|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.0769999022300142
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|P (large endothelial pores)(3.10534206964146E-08 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|Bone|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Bone|Fluid recirculation flow rate(5.33261345230804E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Bone|Lymph flow rate(0.000114014111293118 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)(3817.45165418105 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|Bone|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|Bone|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 559.144621617753 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|Brain|Fraction vascular(0.039)
		V_org: PBPK_model_human_Ab|Organism|Brain|Volume(1.50916227157288 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 1.7251900386897E-10 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Brain|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Brain|Hydraulic conductivity(5E-14 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Brain|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Brain|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Brain|Hydraulic conductivity(5E-14 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Brain|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 17.6768906004709
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|P (large endothelial pores)(1.7251900386897E-10 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|Brain|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Brain|Fluid recirculation flow rate(5.58665816421524E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Brain|Lymph flow rate(3.00487703953774E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|Surface area (plasma/interstitial)(559.144621617753 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 500544313172.706
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|Brain|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Brain|Fluid recirculation flow rate(5.58665816421524E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Brain|Lymph flow rate(3.00487703953774E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|Surface area (plasma/interstitial)(559.144621617753 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|Brain|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|Brain|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 9.88486784853925 [dm²]
	Formula: (V_brn  * 1000 / 1.671)^0.75 * 0.0006 * 1E2
		V_brn: PBPK_model_human_Ab|Organism|Brain|Volume(1.50916227157288 [l])

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2177816930632
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|Partition coefficient (intracellular/plasma)(0.821165243077849)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.821165243077849
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|Brain|Vf (lipid)(0.11)
		f_proteins: PBPK_model_human_Ab|Organism|Brain|Vf (protein)(0.081)
		f_water: PBPK_model_human_Ab|Organism|Brain|Vf (water)(0.808)

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|P_int_cell_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|P_cell_int_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|Surface area (interstitial/intracellular)(9.88486784853925 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|Surface area (interstitial/intracellular)(9.88486784853925 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 2771.82703268068 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|Brain|Fraction vascular(0.039)
		V: PBPK_model_human_Ab|Organism|Brain|Volume(1.50916227157288 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 12425.6689247944 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|Fat|Fraction vascular(0.018)
		V: PBPK_model_human_Ab|Organism|Fat|Volume(14.6582354496615 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 91057.3518774694 [dm²]
	Formula: (V_fat * 1000 / 14.2)^0.75 * 5 * 1E2
		V_fat: PBPK_model_human_Ab|Organism|Fat|Volume(14.6582354496615 [l])

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|P_int_cell_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|P_cell_int_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|Surface area (interstitial/intracellular)(91057.3518774694 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|Surface area (interstitial/intracellular)(91057.3518774694 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.158134014245586
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|Fat|Vf (lipid)(0.8)
		f_proteins: PBPK_model_human_Ab|Organism|Fat|Vf (protein)(0.05)
		f_water: PBPK_model_human_Ab|Organism|Fat|Vf (water)(0.15)

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 6.3237501733623
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|Partition coefficient (intracellular/plasma)(0.158134014245586)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 2506.55826189211 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|Fat|Fraction vascular(0.018)
		V_org: PBPK_model_human_Ab|Organism|Fat|Volume(14.6582354496615 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Fat|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Fat|Hydraulic conductivity(9E-12 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Fat|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.868915940156526
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|P (large endothelial pores)(3.10534206964146E-08 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|Fat|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Fat|Fluid recirculation flow rate(1.77855852400894E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Fat|Lymph flow rate(0.00127932693260599 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|Surface area (plasma/interstitial)(2506.55826189211 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 4777766465446.5
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|Fat|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Fat|Fluid recirculation flow rate(1.77855852400894E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Fat|Lymph flow rate(0.00127932693260599 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|Surface area (plasma/interstitial)(2506.55826189211 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|Fat|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|Fat|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 3.10534206964146E-08 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Fat|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Fat|Hydraulic conductivity(9E-12 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Fat|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 21.0405821679742 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|Gonads|Fraction vascular(0.055)
		V_org: PBPK_model_human_Ab|Organism|Gonads|Volume(0.0402690567808118 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|Gonads|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 7097563849966.31
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|Gonads|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Gonads|Fluid recirculation flow rate(3.20596453218297E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Gonads|Lymph flow rate(1.90943705999462E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|Surface area (plasma/interstitial)(21.0405821679742 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|Gonads|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 3.10534206964146E-08 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Gonads|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Gonads|Hydraulic conductivity(9E-12 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Gonads|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Gonads|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Gonads|Hydraulic conductivity(9E-12 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Gonads|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 5.26822635612042
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|P (large endothelial pores)(3.10534206964146E-08 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|Gonads|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Gonads|Fluid recirculation flow rate(3.20596453218297E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Gonads|Lymph flow rate(1.90943705999462E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|Surface area (plasma/interstitial)(21.0405821679742 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 104.303702801955 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|Gonads|Fraction vascular(0.055)
		V: PBPK_model_human_Ab|Organism|Gonads|Volume(0.0402690567808118 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 1608.0649356657 [dm²]
	Formula: (V_tes * 1000 / 2.5)^0.75 * 2 * 1E2
		V_tes: PBPK_model_human_Ab|Organism|Gonads|Volume(0.0402690567808118 [l])

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|P_int_cell_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|P_cell_int_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|Surface area (interstitial/intracellular)(1608.0649356657 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.819502744189406
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|Gonads|Vf (lipid)(0.031)
		f_proteins: PBPK_model_human_Ab|Organism|Gonads|Vf (protein)(0.12)
		f_water: PBPK_model_human_Ab|Organism|Gonads|Vf (water)(0.8)

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.22025216765946
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|Partition coefficient (intracellular/plasma)(0.819502744189406)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|Surface area (interstitial/intracellular)(1608.0649356657 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 555.410181164296 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|Heart|Fraction vascular(0.14)
		V_org: PBPK_model_human_Ab|Organism|Heart|Volume(0.417601639973155 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 4.94554477757715E-08 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Heart|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Heart|Hydraulic conductivity(1.43333333333333E-11 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Heart|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Heart|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Heart|Hydraulic conductivity(1.43333333333333E-11 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Heart|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.646446707650362
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|P (large endothelial pores)(4.94554477757715E-08 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|Heart|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Heart|Fluid recirculation flow rate(1.13227091465884E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Heart|Lymph flow rate(0.000202809065392218 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|Surface area (plasma/interstitial)(555.410181164296 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 3265080639967.15
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|Heart|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Heart|Fluid recirculation flow rate(1.13227091465884E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Heart|Lymph flow rate(0.000202809065392218 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|Surface area (plasma/interstitial)(555.410181164296 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|Heart|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|Heart|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 2753.31442860541 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|Heart|Fraction vascular(0.14)
		V: PBPK_model_human_Ab|Organism|Heart|Volume(0.417601639973155 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 60751.5073467475 [dm²]
	Formula: (V_hrt * 1000 / 1.2)^0.75 * 7.54 * 1E2
		V_hrt: PBPK_model_human_Ab|Organism|Heart|Volume(0.417601639973155 [l])

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|P_int_cell_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|P_cell_int_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|Surface area (interstitial/intracellular)(60751.5073467475 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|Surface area (interstitial/intracellular)(60751.5073467475 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.31873161968723
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|Partition coefficient (intracellular/plasma)(0.758304407865169)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.758304407865169
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|Heart|Vf (lipid)(0.1)
		f_proteins: PBPK_model_human_Ab|Organism|Heart|Vf (protein)(0.168)
		f_water: PBPK_model_human_Ab|Organism|Heart|Vf (water)(0.731)

Parameter: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|pH(6.25)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|pH(6.25)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: P_1
		P_1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|DrugAbsorption_trans|ProcessRate(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|pH(6.25)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_trans*Aeff*(P_int_trans_lum_cell_factor*min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		Aeff: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Effective surface area(2285.01702047842 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Liquid(0.0257819866318681 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_trans: PBPK_model_human_Ab|CDA1|Intestinal permeability (transcellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		P_int_trans_cell_lum_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|P_int_trans_cell_lum_factor(1)
		P_int_trans_lum_cell_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|P_int_trans_lum_cell_factor(1)
		Solubility: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_trans: PBPK_model_human_Ab|Organism|Lumen|Transcellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|P_int_trans_cell_lum_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_cell_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|P_int_trans_lum_cell_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|pKa_pH_WS_lum_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|DrugAbsorption_trans|ProcessRate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])
	Tags: DrugAbsorption_trans, ProcessRate, CDA1, Lumen_uje_UpperJejunum_cell, Passive
Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Blood flow rate(0.106814822103829 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Lymph flow rate(4.35120274035463E-05 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		C_bc: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Blood flow rate(0.106814822103829 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_cell_Kidney_ur|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.24720705329081
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|Partition coefficient (intracellular/water)(1.24720705329081)

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 4749.0515950945 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|Kidney|Fraction vascular(0.23)
		V: PBPK_model_human_Ab|Organism|Kidney|Volume(0.438443334893072 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 957.998686741362 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|Kidney|Fraction vascular(0.23)
		V_org: PBPK_model_human_Ab|Organism|Kidney|Volume(0.438443334893072 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Kidney|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Kidney|Hydraulic conductivity(1.25E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Kidney|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 4.31297509672425E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Kidney|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Kidney|Hydraulic conductivity(1.25E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Kidney|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.116412201846868
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|P (large endothelial pores)(4.31297509672425E-07 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|Kidney|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Kidney|Fluid recirculation flow rate(3.32038716868045E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Kidney|Lymph flow rate(0.000498718147553631 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)(957.998686741362 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 4598945432668.34
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|Kidney|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Kidney|Fluid recirculation flow rate(3.32038716868045E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Kidney|Lymph flow rate(0.000498718147553631 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)(957.998686741362 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|Kidney|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|Kidney|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_pls|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_para*Aeff*(min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0
		Aeff: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Effective surface area(2285.01702047842 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Liquid(0.0257819866318681 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_para: PBPK_model_human_Ab|CDA1|Intestinal permeability (paracellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_para: PBPK_model_human_Ab|Organism|Lumen|Paracellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_pls|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_pls|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: P_1
		P_1: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_pls|CDA1|DrugAbsorption_para|ProcessRate(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_pls|CDA1|DrugAbsorption_para|ProcessRate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_pls|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])
	Tags: DrugAbsorption_para, ProcessRate, CDA1, Lumen_uje_UpperJejunum_pls, Passive
Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 2226442.96531805 [dm²]
	Formula: (V_kid * 1000 / 7)^0.75 * 1000 * 1E2
		V_kid: PBPK_model_human_Ab|Organism|Kidney|Volume(0.438443334893072 [l])

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|P_cell_int_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|Surface area (interstitial/intracellular)(2226442.96531805 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|Surface area (interstitial/intracellular)(2226442.96531805 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.801791488719904
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|Kidney|Vf (lipid)(0.052)
		f_proteins: PBPK_model_human_Ab|Organism|Kidney|Vf (protein)(0.171)
		f_water: PBPK_model_human_Ab|Organism|Kidney|Vf (water)(0.774)

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.24720705329081
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|Partition coefficient (intracellular/plasma)(0.801791488719904)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|P_int_cell_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_pls|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_para*Aeff*(min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0
		Aeff: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Effective surface area(1779.48258579791 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Liquid(0.0225637095370335 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_para: PBPK_model_human_Ab|CDA1|Intestinal permeability (paracellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_para: PBPK_model_human_Ab|Organism|Lumen|Paracellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_pls|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_pls|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: P_1
		P_1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_pls|CDA1|DrugAbsorption_para|ProcessRate(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_pls|CDA1|DrugAbsorption_para|ProcessRate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_pls|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])
	Tags: DrugAbsorption_para, ProcessRate, CDA1, Lumen_lje_LowerJejunum_pls, Passive
Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Blood flow rate(0.106814822103829 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Lymph flow rate(3.21534660331426E-05 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: P_1
		P_1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|DrugAbsorption_trans|ProcessRate(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|pH(6.9167)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|pH(6.9167)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_trans*Aeff*(P_int_trans_lum_cell_factor*min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		Aeff: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Effective surface area(1779.48258579791 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Liquid(0.0225637095370335 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_trans: PBPK_model_human_Ab|CDA1|Intestinal permeability (transcellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		P_int_trans_cell_lum_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|P_int_trans_cell_lum_factor(1)
		P_int_trans_lum_cell_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|P_int_trans_lum_cell_factor(1)
		Solubility: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_trans: PBPK_model_human_Ab|Organism|Lumen|Transcellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|P_int_trans_cell_lum_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|P_int_trans_lum_cell_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|pH(6.9167)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|DrugAbsorption_trans|ProcessRate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])
	Tags: DrugAbsorption_trans, ProcessRate, CDA1, Lumen_lje_LowerJejunum_cell, Passive
Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_sto_Lumen_duo|CDA1|Oral mass absorbed
	IsFixed: False
	Value: 0 [µmol]
	Formula: MAbs_duo + MAbs_uje + MAbs_lje + MAbs_uil + MAbs_lil + MAbs_cae + MAbs_colasc + MAbs_coltrans + MAbs_coldesc + MAbs_colsigm + MAbs_rect
		MAbs_cae: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|Oral mass absorbed segment(0 [µmol])
		MAbs_colasc: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|Oral mass absorbed segment(0 [µmol])
		MAbs_coldesc: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|Oral mass absorbed segment(0 [µmol])
		MAbs_colsigm: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|Oral mass absorbed segment(0 [µmol])
		MAbs_coltrans: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|Oral mass absorbed segment(0 [µmol])
		MAbs_duo: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|Oral mass absorbed segment(0 [µmol])
		MAbs_lil: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|Oral mass absorbed segment(0 [µmol])
		MAbs_lje: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|Oral mass absorbed segment(0 [µmol])
		MAbs_rect: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|Oral mass absorbed segment(0 [µmol])
		MAbs_uil: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|Oral mass absorbed segment(0 [µmol])
		MAbs_uje: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|Oral mass absorbed segment(0 [µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		C_bc: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Blood flow rate(0.106814822103829 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		C_bc: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Blood flow rate(0.114374775266429 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 51.2375108392571 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|Stomach|Fraction vascular(0.032)
		V_org: PBPK_model_human_Ab|Organism|Stomach|Volume(0.168544443550188 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Stomach|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Stomach|Hydraulic conductivity(3.97222222222222E-11 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Stomach|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 1.07177377725536
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|P (large endothelial pores)(1.37056764184793E-07 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|Stomach|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Stomach|Fluid recirculation flow rate(5.57959880187978E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Stomach|Lymph flow rate(7.03591004386913E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)(51.2375108392571 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 11956386173221.3
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|Stomach|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Stomach|Fluid recirculation flow rate(5.57959880187978E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Stomach|Lymph flow rate(7.03591004386913E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)(51.2375108392571 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|Stomach|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|Stomach|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 1.37056764184793E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Stomach|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Stomach|Hydraulic conductivity(3.97222222222222E-11 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Stomach|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 253.997824785681 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|Stomach|Fraction vascular(0.032)
		V: PBPK_model_human_Ab|Organism|Stomach|Volume(0.168544443550188 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 4355031.65253801 [dm²]
	Formula: (V_sto * 1000 / 1.1)^0.75 * 1000 * 1E2
		V_sto: PBPK_model_human_Ab|Organism|Stomach|Volume(0.168544443550188 [l])

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|P_int_cell_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|P_cell_int_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|Surface area (interstitial/intracellular)(4355031.65253801 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|Surface area (interstitial/intracellular)(4355031.65253801 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813615817893258
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|Stomach|Vf (lipid)(0.062)
		f_proteins: PBPK_model_human_Ab|Organism|Stomach|Vf (protein)(0.133)
		f_water: PBPK_model_human_Ab|Organism|Stomach|Vf (water)(0.792)

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.22908131578533
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813615817893258)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: P_1
		P_1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|DrugAbsorption_trans|ProcessRate(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|pH(7.2083)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|pH(7.2083)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|pH(7.2083)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_trans*Aeff*(P_int_trans_lum_cell_factor*min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		Aeff: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Effective surface area(1658.15372565961 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Liquid(0.0270026140608501 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_trans: PBPK_model_human_Ab|CDA1|Intestinal permeability (transcellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		P_int_trans_cell_lum_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|P_int_trans_cell_lum_factor(1)
		P_int_trans_lum_cell_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|P_int_trans_lum_cell_factor(1)
		Solubility: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_trans: PBPK_model_human_Ab|Organism|Lumen|Transcellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|P_int_trans_cell_lum_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_cell_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|P_int_trans_lum_cell_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|pKa_pH_WS_lum_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|DrugAbsorption_trans|ProcessRate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])
	Tags: DrugAbsorption_trans, ProcessRate, CDA1, Lumen_uil_UpperIleum_cell, Passive
Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_pls|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_para*Aeff*(min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0
		Aeff: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Effective surface area(1658.15372565961 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Liquid(0.0270026140608501 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_para: PBPK_model_human_Ab|CDA1|Intestinal permeability (paracellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_para: PBPK_model_human_Ab|Organism|Lumen|Paracellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_pls|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_pls|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: P_1
		P_1: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_pls|CDA1|DrugAbsorption_para|ProcessRate(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_pls|CDA1|DrugAbsorption_para|ProcessRate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_pls|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])
	Tags: DrugAbsorption_para, ProcessRate, CDA1, Lumen_uil_UpperIleum_pls, Passive
Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Blood flow rate(0.114374775266429 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Lymph flow rate(2.8309029877006E-05 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_bc_LowerJejunum_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Blood flow rate(0.106814822103829 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_LowerJejunum_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Blood flow rate(0.106814822103829 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Lymph flow rate(3.21534660331426E-05 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_pls|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_para*Aeff*(min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0
		Aeff: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Effective surface area(788.634160322344 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Liquid(0.019348329927017 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_para: PBPK_model_human_Ab|CDA1|Intestinal permeability (paracellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_para: PBPK_model_human_Ab|Organism|Lumen|Paracellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_pls|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_pls|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: P_1
		P_1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_pls|CDA1|DrugAbsorption_para|ProcessRate(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_pls|CDA1|DrugAbsorption_para|ProcessRate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_pls|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])
	Tags: DrugAbsorption_para, ProcessRate, CDA1, Lumen_lil_LowerIleum_pls, Passive
Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_trans*Aeff*(P_int_trans_lum_cell_factor*min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		Aeff: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Effective surface area(788.634160322344 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Liquid(0.019348329927017 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_trans: PBPK_model_human_Ab|CDA1|Intestinal permeability (transcellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		P_int_trans_cell_lum_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|P_int_trans_cell_lum_factor(1)
		P_int_trans_lum_cell_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|P_int_trans_lum_cell_factor(1)
		Solubility: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_trans: PBPK_model_human_Ab|Organism|Lumen|Transcellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|P_int_trans_lum_cell_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|P_int_trans_cell_lum_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|pH(7.4583)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: P_1
		P_1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|DrugAbsorption_trans|ProcessRate(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|pH(7.4583)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|pH(7.4583)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|DrugAbsorption_trans|ProcessRate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])
	Tags: DrugAbsorption_trans, ProcessRate, CDA1, Lumen_lil_LowerIleum_cell, Passive
Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 657.03249526309 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * (V-V_Mucosa) * f_vas
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction vascular(0.024)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_Mucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Volume (mucosa)(0.143154844093362 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_bc_UpperIleum_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Blood flow rate(0.114374775266429 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_UpperIleum_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Blood flow rate(0.114374775266429 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Lymph flow rate(2.8309029877006E-05 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 132.539361808285 [dm²]
	Formula: k * f_vas_org * (V_org-V_Mucosa)
		f_vas_org: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction vascular(0.024)
		V_org: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_Mucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Volume (mucosa)(0.143154844093362 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.425117328598339
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|P (large endothelial pores)(5.30975156352275E-07 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Fluid recirculation flow rate(9.19788233160212E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow rate(0.000539296428616088 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)(132.539361808285 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 5.30975156352275E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|SmallIntestine|Hydraulic conductivity(1.53888888888889E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|SmallIntestine|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 37961079485312
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Fluid recirculation flow rate(9.19788233160212E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Lymph flow rate(0.000539296428616088 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)(132.539361808285 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|SmallIntestine|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|SmallIntestine|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|SmallIntestine|Hydraulic conductivity(1.53888888888889E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|SmallIntestine|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		C_bc: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Blood flow rate(0.114374775266429 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Blood flow rate(0.114374775266429 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Lymph flow rate(1.36302736444844E-05 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_bc_LowerIleum_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Blood flow rate(0.114374775266429 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_LowerIleum_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Blood flow rate(0.114374775266429 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Lymph flow rate(1.36302736444844E-05 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_bc_Duodenum_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Blood flow rate(0.0453597189755988 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 1946772.87733529 [dm²]
	Formula: ((V_sin-V_Mucosa) * 1000 / 11.1)^0.75 * 1000 * 1E2
		V_sin: PBPK_model_human_Ab|Organism|SmallIntestine|Volume(0.724467834480575 [l])
		V_Mucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Volume (mucosa)(0.143154844093362 [l])

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|Surface area (interstitial/intracellular)(1946772.87733529 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|Surface area (interstitial/intracellular)(1946772.87733529 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813615817893258
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (lipid)(0.062)
		f_proteins: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (protein)(0.133)
		f_water: PBPK_model_human_Ab|Organism|SmallIntestine|Vf (water)(0.792)

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.22908131578533
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813615817893258)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|P_cell_int_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|P_int_cell_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_UpperJejunum_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Blood flow rate(0.106814822103829 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Lymph flow rate(4.35120274035463E-05 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_Duodenum_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Blood flow rate(0.0453597189755988 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Lymph flow rate(1.52029975265403E-05 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_bc_UpperJejunum_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Blood flow rate(0.106814822103829 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 1269087.93467593 [dm²]
	Formula: ((V_lin-V_Mucosa) * 1000 / 11.1)^0.75 * 1000 * 1E2
		V_lin: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_Mucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Volume (mucosa)(0.0838988315131993 [l])

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813615817893258
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (lipid)(0.062)
		f_proteins: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (protein)(0.133)
		f_water: PBPK_model_human_Ab|Organism|LargeIntestine|Vf (water)(0.792)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.22908131578533
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813615817893258)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|Surface area (interstitial/intracellular)(1269087.93467593 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|Surface area (interstitial/intracellular)(1269087.93467593 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|P_int_cell_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|P_cell_int_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 74.9169542468954 [dm²]
	Formula: k * f_vas_org * (V_org-V_Mucosa)
		f_vas_org: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction vascular(0.024)
		V_org: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_Mucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Volume (mucosa)(0.0838988315131993 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|LargeIntestine|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 6.45029386687872E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|LargeIntestine|Hydraulic conductivity(1.86944444444444E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|LargeIntestine|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|LargeIntestine|Hydraulic conductivity(1.86944444444444E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|LargeIntestine|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 1.77598794053127
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|P (large endothelial pores)(6.45029386687872E-07 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Fluid recirculation flow rate(2.46800420274831E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate(0.0015811341483735 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)(74.9169542468954 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|LargeIntestine|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 197204680005871
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Fluid recirculation flow rate(2.46800420274831E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Lymph flow rate(0.0015811341483735 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)(74.9169542468954 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 371.38305718982 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * (V-V_Mucosa) * f_vas
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction vascular(0.024)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Volume(0.412481964175021 [l])
		V_Mucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Volume (mucosa)(0.0838988315131993 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_ColonDescendens_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Blood flow rate(0.0468125781142232 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Lymph flow rate(6.66910712846469E-05 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_ColonTransversum_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Blood flow rate(0.0624167708189642 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Lymph flow rate(0.000133382142569294 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_ColonAscendens_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Blood flow rate(0.0302896885639905 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Lymph flow rate(5.85648492003344E-05 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_Caecum_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Blood flow rate(0.0165221093405974 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_ColonDescendens_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Blood flow rate(0.0468125781142232 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_ColonTransversum_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Blood flow rate(0.0624167708189642 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_ColonAscendens_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Blood flow rate(0.0302896885639905 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_ColonSigmoid_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Blood flow rate(0.0263320751892505 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Lymph flow rate(8.0386559137744E-05 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_Caecum_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Blood flow rate(0.0165221093405974 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Lymph flow rate(3.19444618288292E-05 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_Rectum_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Blood flow rate(0.0107278824845095 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_Rectum_pls|CDA1|Mass transfer rate (intestine to mucosa plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Blood flow rate(0.0107278824845095 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Lymph flow rate(3.27500796487105E-05 [l/min])
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_ColonSigmoid_bc|CDA1|Mass transfer rate (intestine to mucosa blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Blood flow rate(0.0263320751892505 [l/min])
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 3838.19602558808 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|Liver|Fraction vascular(0.17)
		V_org: PBPK_model_human_Ab|Organism|Liver|Volume(2.37659196630841 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Liver_pls_Liver_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 19026.9477504258 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|Liver|Fraction vascular(0.17)
		V: PBPK_model_human_Ab|Organism|Liver|Volume(2.37659196630841 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Liver_int_Liver_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 496340.62236405 [dm²]
	Formula: (V_liv * 1000 / 10)^0.75 * 82 * 1E2
		V_liv: PBPK_model_human_Ab|Organism|Liver|Volume(2.37659196630841 [l])

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 3838.19602558808 [dm²]
	Formula: SA_pls_int * (IsLiverZonated?  f_periportal : 1)
		f_periportal: PBPK_model_human_Ab|Organism|Liver|Fraction of periportal zone(0.5)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)(3838.19602558808 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 0.593333333333333
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|Liver|Periportal|Radius (small pores)(9E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 1.64194864611518E-06 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Radius ratio (solute/large pores)(0.161818181818182)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Liver|Periportal|Flow fraction via large pores(0.8)
		Lp: PBPK_model_human_Ab|Organism|Liver|Periportal|Hydraulic conductivity(3.88888888888889E-11 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Liver|Periportal|Radius (large pores)(3.3E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1.8023805824505E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Radius ratio (solute/small pores)(0.593333333333333)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Liver|Periportal|Flow fraction via large pores(0.8)
		Lp: PBPK_model_human_Ab|Organism|Liver|Periportal|Hydraulic conductivity(3.88888888888889E-11 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Liver|Periportal|Radius (small pores)(9E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.520953407333685
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|P (large endothelial pores)(1.64194864611518E-06 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Reflection coefficient (large pores)(0.104991965143301)
		alpha_l: PBPK_model_human_Ab|Organism|Liver|Periportal|Flow fraction via large pores(0.8)
		J_iso: PBPK_model_human_Ab|Organism|Liver|Periportal|Fluid recirculation flow rate(7.07876482920826E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Liver|Periportal|Lymph flow rate(0.00449682523507667 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|Surface area (plasma/interstitial)(3838.19602558808 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 0.28114689432112
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|P (small endothelial pores)(1.8023805824505E-07 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Reflection coefficient (small pores)(0.765267156885655)
		alpha_l: PBPK_model_human_Ab|Organism|Liver|Periportal|Flow fraction via large pores(0.8)
		J_iso: PBPK_model_human_Ab|Organism|Liver|Periportal|Fluid recirculation flow rate(7.07876482920826E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Liver|Periportal|Lymph flow rate(0.00449682523507667 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|Surface area (plasma/interstitial)(3838.19602558808 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.161818181818182
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|Liver|Periportal|Radius (large pores)(3.3E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.104991965143301
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Radius ratio (solute/large pores)(0.161818181818182)

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.765267156885655
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Radius ratio (solute/small pores)(0.593333333333333)

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 19026.9477504258 [dm²]
	Formula: SA_pls_bc * (IsLiverZonated?  f_periportal : 1)
		f_periportal: PBPK_model_human_Ab|Organism|Liver|Fraction of periportal zone(0.5)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)
		SA_pls_bc: PBPK_model_human_Ab|Neighborhoods|Liver_pls_Liver_bc|Surface area (blood cells/plasma)(19026.9477504258 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 496340.62236405 [dm²]
	Formula: SA_int_cell * (IsLiverZonated?  f_periportal : 1)
		f_periportal: PBPK_model_human_Ab|Organism|Liver|Fraction of periportal zone(0.5)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)
		SA_int_cell: PBPK_model_human_Ab|Neighborhoods|Liver_int_Liver_cell|Surface area (interstitial/intracellular)(496340.62236405 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|P_int_cell_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|P_cell_int_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|Surface area (interstitial/intracellular)(496340.62236405 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|Surface area (interstitial/intracellular)(496340.62236405 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.776904422423756
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (lipid)(0.069)
		f_proteins: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (protein)(0.184)
		f_water: PBPK_model_human_Ab|Organism|Liver|Periportal|Vf (water)(0.747)

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.28715961852841
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|Partition coefficient (intracellular/plasma)(0.776904422423756)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 0 [dm²]
	Formula: SA_pls_bc * (IsLiverZonated?  1-f_periportal : 0)
		f_periportal: PBPK_model_human_Ab|Organism|Liver|Fraction of periportal zone(0.5)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)
		SA_pls_bc: PBPK_model_human_Ab|Neighborhoods|Liver_pls_Liver_bc|Surface area (blood cells/plasma)(19026.9477504258 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 0 [dm²]
	Formula: SA_int_cell * (IsLiverZonated?  1-f_periportal : 0)
		f_periportal: PBPK_model_human_Ab|Organism|Liver|Fraction of periportal zone(0.5)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)
		SA_int_cell: PBPK_model_human_Ab|Neighborhoods|Liver_int_Liver_cell|Surface area (interstitial/intracellular)(496340.62236405 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.776904422423756
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (lipid)(0.069)
		f_proteins: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (protein)(0.184)
		f_water: PBPK_model_human_Ab|Organism|Liver|Pericentral|Vf (water)(0.747)

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.28715961852841
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|Partition coefficient (intracellular/plasma)(0.776904422423756)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|Surface area (interstitial/intracellular)(0 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|P_cell_int_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|Surface area (interstitial/intracellular)(0 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|P_int_cell_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 0 [dm²]
	Formula: SA_pls_int * (IsLiverZonated?  1-f_periportal : 0)
		f_periportal: PBPK_model_human_Ab|Organism|Liver|Fraction of periportal zone(0.5)
		IsLiverZonated: PBPK_model_human_Ab|Organism|Liver|Is liver zonated(0)
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)(3838.19602558808 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.765267156885655
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Radius ratio (solute/small pores)(0.593333333333333)

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 0.593333333333333
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|Liver|Pericentral|Radius (small pores)(9E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.104991965143301
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Radius ratio (solute/large pores)(0.161818181818182)

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 1.64194864611518E-06 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Radius ratio (solute/large pores)(0.161818181818182)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Liver|Pericentral|Flow fraction via large pores(0.8)
		Lp: PBPK_model_human_Ab|Organism|Liver|Pericentral|Hydraulic conductivity(3.88888888888889E-11 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Liver|Pericentral|Radius (large pores)(3.3E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.161818181818182
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|Liver|Pericentral|Radius (large pores)(3.3E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1.8023805824505E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Radius ratio (solute/small pores)(0.593333333333333)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Liver|Pericentral|Flow fraction via large pores(0.8)
		Lp: PBPK_model_human_Ab|Organism|Liver|Pericentral|Hydraulic conductivity(3.88888888888889E-11 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Liver|Pericentral|Radius (small pores)(9E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: NaN
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|P (small endothelial pores)(1.8023805824505E-07 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Reflection coefficient (small pores)(0.765267156885655)
		alpha_l: PBPK_model_human_Ab|Organism|Liver|Pericentral|Flow fraction via large pores(0.8)
		J_iso: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fluid recirculation flow rate(0 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Liver|Pericentral|Lymph flow rate(0 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|Surface area (plasma/interstitial)(0 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: NaN
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|P (large endothelial pores)(1.64194864611518E-06 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1|Reflection coefficient (large pores)(0.104991965143301)
		alpha_l: PBPK_model_human_Ab|Organism|Liver|Pericentral|Flow fraction via large pores(0.8)
		J_iso: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fluid recirculation flow rate(0 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Liver|Pericentral|Lymph flow rate(0 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|Surface area (plasma/interstitial)(0 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 33170.1412548371 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|Lung|Fraction vascular(0.58)
		V: PBPK_model_human_Ab|Organism|Lung|Volume(1.21437760044244 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 1093.25011921034 [dm²]
	Formula: (V_lng * 1000  / 2.2)^0.75 * 0.096 * 1E2
		V_lng: PBPK_model_human_Ab|Organism|Lung|Volume(1.21437760044244 [l])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|P_int_cell_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|P_cell_int_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|Surface area (interstitial/intracellular)(1093.25011921034 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|Surface area (interstitial/intracellular)(1093.25011921034 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.836741312138844
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|Lung|Vf (lipid)(0.01)
		f_proteins: PBPK_model_human_Ab|Organism|Lung|Vf (protein)(0.183)
		f_water: PBPK_model_human_Ab|Organism|Lung|Vf (water)(0.807)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.19511249832262
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|Partition coefficient (intracellular/plasma)(0.836741312138844)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 6691.22057843786 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|Lung|Fraction vascular(0.58)
		V_org: PBPK_model_human_Ab|Organism|Lung|Volume(1.21437760044244 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Lung|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Lung|Hydraulic conductivity(5.66666666666667E-12 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Lung|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.0366305942783084
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|P (large endothelial pores)(1.95521537718166E-08 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|Lung|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Lung|Fluid recirculation flow rate(4.76380931227607E-08 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Lung|Lymph flow rate(0.000114900141047345 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)(6691.22057843786 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 163060677230.473
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|Lung|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Lung|Fluid recirculation flow rate(4.76380931227607E-08 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Lung|Lymph flow rate(0.000114900141047345 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)(6691.22057843786 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|Lung|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|Lung|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 1.95521537718166E-08 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Lung|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Lung|Hydraulic conductivity(5.66666666666667E-12 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Lung|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 53869.851493137 [dm²]
	Formula: (V_mus * 1000 / 110.1)^0.75 * 7.54 * 1E2
		V_mus: PBPK_model_human_Ab|Organism|Muscle|Volume(32.6402313917433 [l])

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|P_cell_int_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|P_int_cell_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|Surface area (interstitial/intracellular)(53869.851493137 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|Surface area (interstitial/intracellular)(53869.851493137 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.839766220429374
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|Muscle|Vf (lipid)(0.013)
		f_proteins: PBPK_model_human_Ab|Organism|Muscle|Vf (protein)(0.177)
		f_water: PBPK_model_human_Ab|Organism|Muscle|Vf (water)(0.811)

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.19080760296443
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|Partition coefficient (intracellular/plasma)(0.839766220429374)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 7752.05495553904 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|Muscle|Fraction vascular(0.025)
		V_org: PBPK_model_human_Ab|Organism|Muscle|Volume(32.6402313917433 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 1428147911161.36
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|Muscle|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Muscle|Fluid recirculation flow rate(2.2292095155886E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Muscle|Lymph flow rate(0.00118884232037053 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)(7752.05495553904 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|Muscle|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|Muscle|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Muscle|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Muscle|Hydraulic conductivity(9E-12 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Muscle|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.280895367290855
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|P (large endothelial pores)(3.10534206964146E-08 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|Muscle|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Muscle|Fluid recirculation flow rate(2.2292095155886E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Muscle|Lymph flow rate(0.00118884232037053 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)(7752.05495553904 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 3.10534206964146E-08 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Muscle|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Muscle|Hydraulic conductivity(9E-12 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Muscle|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 38428.976429069 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|Muscle|Fraction vascular(0.025)
		V: PBPK_model_human_Ab|Organism|Muscle|Volume(32.6402313917433 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 1793.69915056893 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|Pancreas|Fraction vascular(0.2)
		V: PBPK_model_human_Ab|Organism|Pancreas|Volume(0.19043818220675 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 361.832546192824 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|Pancreas|Fraction vascular(0.2)
		V_org: PBPK_model_human_Ab|Organism|Pancreas|Volume(0.19043818220675 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|Pancreas|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 1.11178913604447E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Pancreas|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Pancreas|Hydraulic conductivity(3.22222222222222E-11 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Pancreas|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Pancreas|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Pancreas|Hydraulic conductivity(3.22222222222222E-11 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Pancreas|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 1.09320443024707
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|P (large endothelial pores)(1.11178913604447E-07 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|Pancreas|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Pancreas|Fluid recirculation flow rate(8.76759089031544E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Pancreas|Lymph flow rate(0.0010456145699991 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)(361.832546192824 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 27428629426862.6
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|Pancreas|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Pancreas|Fluid recirculation flow rate(8.76759089031544E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Pancreas|Lymph flow rate(0.0010456145699991 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)(361.832546192824 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|Pancreas|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 4210735.93126953 [dm²]
	Formula: (V_pan * 1000 / 1.3)^0.75 * 1000 * 1E2
		V_pan: PBPK_model_human_Ab|Organism|Pancreas|Volume(0.19043818220675 [l])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.731128437038523
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|Pancreas|Vf (lipid)(0.08)
		f_proteins: PBPK_model_human_Ab|Organism|Pancreas|Vf (protein)(0.13)
		f_water: PBPK_model_human_Ab|Organism|Pancreas|Vf (water)(0.71)

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|P_int_cell_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|P_cell_int_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|Surface area (interstitial/intracellular)(4210735.93126953 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|Surface area (interstitial/intracellular)(4210735.93126953 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.36774874200018
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|Partition coefficient (intracellular/plasma)(0.731128437038523)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Blood flow rate(0.0107278824845095 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Lymph flow rate(3.27500796487105E-05 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Blood flow rate(0.0107278824845095 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|Rectum|pH(6.6)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|Rectum|pH(6.6)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|Rectum|pH(6.6)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: P_1
		P_1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|DrugAbsorption_trans|ProcessRate(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_trans*Aeff*(P_int_trans_lum_cell_factor*min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		Aeff: PBPK_model_human_Ab|Organism|Lumen|Rectum|Effective surface area(3.84643425864822 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Rectum|Liquid(0.000525578833597355 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_trans: PBPK_model_human_Ab|CDA1|Intestinal permeability (transcellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		P_int_trans_cell_lum_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|P_int_trans_cell_lum_factor(1)
		P_int_trans_lum_cell_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|P_int_trans_lum_cell_factor(1)
		Solubility: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_trans: PBPK_model_human_Ab|Organism|Lumen|Transcellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|P_int_trans_cell_lum_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|P_int_trans_lum_cell_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_lum_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|pKa_pH_WS_cell_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|DrugAbsorption_trans|ProcessRate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])
	Tags: DrugAbsorption_trans, ProcessRate, CDA1, Lumen_rect_Rectum_cell, Passive
Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_pls|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_para*Aeff*(min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0
		Aeff: PBPK_model_human_Ab|Organism|Lumen|Rectum|Effective surface area(3.84643425864822 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Rectum|Liquid(0.000525578833597355 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_para: PBPK_model_human_Ab|CDA1|Intestinal permeability (paracellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_para: PBPK_model_human_Ab|Organism|Lumen|Paracellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_pls|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_pls|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|PortalVein_pls_PortalVein_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 48857.0356599865 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V
		V: PBPK_model_human_Ab|Organism|PortalVein|Volume(1.03743652397304 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 1644.40812833086 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|Skin|Fraction vascular(0.046)
		V_org: PBPK_model_human_Ab|Organism|Skin|Volume(3.76294766208435 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 6.71864909427472E-08 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Skin|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Skin|Hydraulic conductivity(1.94722E-11 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Skin|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Skin|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|Skin|Hydraulic conductivity(1.94722E-11 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Skin|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.472032370689744
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|P (large endothelial pores)(6.71864909427472E-08 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|Skin|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Skin|Fluid recirculation flow rate(3.26924996641784E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Skin|Lymph flow rate(0.000606892413442345 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)(1644.40812833086 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 3307301172599.32
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|Skin|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|Skin|Fluid recirculation flow rate(3.26924996641784E-05 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Skin|Lymph flow rate(0.000606892413442345 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)(1644.40812833086 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|Skin|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|Skin|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 340.965220839807 [dm²]
	Formula: (V_skn * 1000 / 43.4)^0.75 * 0.12 * 1E2
		V_skn: PBPK_model_human_Ab|Organism|Skin|Volume(3.76294766208435 [l])

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|P_int_cell_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|P_cell_int_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|Surface area (interstitial/intracellular)(340.965220839807 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|Surface area (interstitial/intracellular)(340.965220839807 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.51789558967143
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|Partition coefficient (intracellular/plasma)(0.658806842054575)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.658806842054575
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|Skin|Vf (lipid)(0.1)
		f_proteins: PBPK_model_human_Ab|Organism|Skin|Vf (protein)(0.288)
		f_water: PBPK_model_human_Ab|Organism|Skin|Vf (water)(0.612)

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 8151.76383111721 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|Skin|Fraction vascular(0.046)
		V: PBPK_model_human_Ab|Organism|Skin|Volume(3.76294766208435 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 4481280.62005514 [dm²]
	Formula: (V_spl * 1000 / 1.3)^0.75 * 1000 * 1E2
		V_spl: PBPK_model_human_Ab|Organism|Spleen|Volume(0.206924956693567 [l])

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.809529095272873
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|Spleen|Vf (lipid)(0.016)
		f_proteins: PBPK_model_human_Ab|Organism|Spleen|Vf (protein)(0.194)
		f_water: PBPK_model_human_Ab|Organism|Spleen|Vf (water)(0.778)

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.23528605190271
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|Partition coefficient (intracellular/plasma)(0.809529095272873)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|Surface area (interstitial/intracellular)(4481280.62005514 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|P_int_cell_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|P_cell_int_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|Surface area (interstitial/intracellular)(4481280.62005514 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 3215.82489047386 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|Spleen|Fraction vascular(0.33)
		V: PBPK_model_human_Ab|Organism|Spleen|Volume(0.206924956693567 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 648.709739234333 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|Spleen|Fraction vascular(0.33)
		V_org: PBPK_model_human_Ab|Organism|Spleen|Volume(0.206924956693567 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.104991965143301
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Radius ratio (solute/large pores)(0.161818181818182)

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 1.64194864611518E-06 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Radius ratio (solute/large pores)(0.161818181818182)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Spleen|Flow fraction via large pores(0.8)
		Lp: PBPK_model_human_Ab|Organism|Spleen|Hydraulic conductivity(3.88888888888889E-11 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Spleen|Radius (large pores)(3.3E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1.8023805824505E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Radius ratio (solute/small pores)(0.593333333333333)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|Spleen|Flow fraction via large pores(0.8)
		Lp: PBPK_model_human_Ab|Organism|Spleen|Hydraulic conductivity(3.88888888888889E-11 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|Spleen|Radius (small pores)(9E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 1.17553197897659
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|P (large endothelial pores)(1.64194864611518E-06 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Reflection coefficient (large pores)(0.104991965143301)
		alpha_l: PBPK_model_human_Ab|Organism|Spleen|Flow fraction via large pores(0.8)
		J_iso: PBPK_model_human_Ab|Organism|Spleen|Fluid recirculation flow rate(2.75110022586197E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Spleen|Lymph flow rate(0.00174840525680567 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)(648.709739234333 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 0.701466970346817
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|P (small endothelial pores)(1.8023805824505E-07 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Reflection coefficient (small pores)(0.765267156885655)
		alpha_l: PBPK_model_human_Ab|Organism|Spleen|Flow fraction via large pores(0.8)
		J_iso: PBPK_model_human_Ab|Organism|Spleen|Fluid recirculation flow rate(2.75110022586197E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|Spleen|Lymph flow rate(0.00174840525680567 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)(648.709739234333 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 0.593333333333333
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|Spleen|Radius (small pores)(9E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.765267156885655
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Radius ratio (solute/small pores)(0.593333333333333)

Parameter: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.161818181818182
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|Spleen|Radius (large pores)(3.3E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_int_EndogenousIgG_pls|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 29612.719787982 [dm²]
	Formula: SA_pls_int_bon+SA_pls_int_brn+SA_pls_int_fat+SA_pls_int_tes+SA_pls_int_hrt+SA_pls_int_kid+SA_pls_int_lin+SA_pls_int_liv+SA_pls_int_lng+SA_pls_int_mus+SA_pls_int_pan+SA_pls_int_skn+SA_pls_int_sin+SA_pls_int_spl+SA_pls_int_sto
		SA_pls_int_bon: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|Surface area (plasma/interstitial)(3817.45165418105 [dm²])
		SA_pls_int_brn: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|Surface area (plasma/interstitial)(559.144621617753 [dm²])
		SA_pls_int_fat: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|Surface area (plasma/interstitial)(2506.55826189211 [dm²])
		SA_pls_int_tes: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|Surface area (plasma/interstitial)(21.0405821679742 [dm²])
		SA_pls_int_hrt: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|Surface area (plasma/interstitial)(555.410181164296 [dm²])
		SA_pls_int_kid: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|Surface area (plasma/interstitial)(957.998686741362 [dm²])
		SA_pls_int_lin: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|Surface area (plasma/interstitial)(74.9169542468954 [dm²])
		SA_pls_int_liv: PBPK_model_human_Ab|Neighborhoods|Liver_pls_Liver_int|Surface area (plasma/interstitial)(3838.19602558808 [dm²])
		SA_pls_int_lng: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|Surface area (plasma/interstitial)(6691.22057843786 [dm²])
		SA_pls_int_mus: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|Surface area (plasma/interstitial)(7752.05495553904 [dm²])
		SA_pls_int_pan: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|Surface area (plasma/interstitial)(361.832546192824 [dm²])
		SA_pls_int_skn: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|Surface area (plasma/interstitial)(1644.40812833086 [dm²])
		SA_pls_int_sin: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|Surface area (plasma/interstitial)(132.539361808285 [dm²])
		SA_pls_int_spl: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|Surface area (plasma/interstitial)(648.709739234333 [dm²])
		SA_pls_int_sto: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|Surface area (plasma/interstitial)(51.2375108392571 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Saliva_slv_Saliva_slv|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 1
	Formula: R * fu
		R: PBPK_model_human_Ab|Neighborhoods|Saliva_slv_Saliva_slv|CDA1|SalivaPlasmaRatio(1)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Saliva_slv_Saliva_slv|CDA1|SalivaPlasmaRatio
	IsFixed: False
	Value: 1
	Formula: 1
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH_slv: PBPK_model_human_Ab|Organism|Saliva|Saliva|pH (saliva)(7.4)
		pH_PLS: PBPK_model_human_Ab|Organism|pH (plasma)(7.4)

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 27.905516892085 [dm²]
	Formula: Aeff / MicrovilliFactor
		Aeff: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Effective surface area(697.637922302124 [dm²])
		MicrovilliFactor: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Microvilli factor(25)

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|Surface area (interstitial/intracellular)(27.905516892085 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor * P_int_scalefactor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|P_int_cell_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor * P_int_scalefactor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|P_cell_int_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|Surface area (interstitial/intracellular)(27.905516892085 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (lipid)(0.06)
		f_proteins: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (protein)(0.08)
		f_water: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Vf (water)(0.8)

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 100.327650152181 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction vascular(0.13)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Volume(0.0163874624159506 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 20.238516083699 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fraction vascular(0.13)
		V_org: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Volume(0.0163874624159506 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 5.30975156352275E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Hydraulic conductivity(1.53888888888889E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Hydraulic conductivity(1.53888888888889E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.0784831991258472
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|P (large endothelial pores)(5.30975156352275E-07 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fluid recirculation flow rate(2.59292246187488E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Lymph flow rate(1.52029975265403E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)(20.238516083699 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 7008199289596.06
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Fluid recirculation flow rate(2.59292246187488E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Lymph flow rate(1.52029975265403E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|Surface area (plasma/interstitial)(20.238516083699 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 57.9240287912764 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction vascular(0.13)
		V_org: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Volume(0.0469020476042724 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 5.30975156352275E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Hydraulic conductivity(1.53888888888889E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Hydraulic conductivity(1.53888888888889E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.0784831991258473
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|P (large endothelial pores)(5.30975156352275E-07 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fluid recirculation flow rate(7.42112290812464E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Lymph flow rate(4.35120274035463E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)(57.9240287912764 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 7008199289596.06
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fluid recirculation flow rate(7.42112290812464E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Lymph flow rate(4.35120274035463E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|Surface area (plasma/interstitial)(57.9240287912764 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 287.144653883829 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Fraction vascular(0.13)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Volume(0.0469020476042724 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 91.4006808191366 [dm²]
	Formula: Aeff / MicrovilliFactor
		Aeff: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Effective surface area(2285.01702047842 [dm²])
		MicrovilliFactor: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Microvilli factor(25)

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor * P_int_scalefactor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|P_int_cell_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor * P_int_scalefactor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|P_cell_int_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Surface area (interstitial/intracellular)(91.4006808191366 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|Surface area (interstitial/intracellular)(91.4006808191366 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (lipid)(0.06)
		f_proteins: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (protein)(0.08)
		f_water: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Vf (water)(0.8)

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 212.187214114958 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction vascular(0.13)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Volume(0.0346585412015507 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 71.1793034319165 [dm²]
	Formula: Aeff / MicrovilliFactor
		Aeff: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Effective surface area(1779.48258579791 [dm²])
		MicrovilliFactor: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Microvilli factor(25)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor * P_int_scalefactor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|P_int_cell_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor * P_int_scalefactor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|P_cell_int_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Surface area (interstitial/intracellular)(71.1793034319165 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|Surface area (interstitial/intracellular)(71.1793034319165 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (lipid)(0.06)
		f_proteins: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (protein)(0.08)
		f_water: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Vf (water)(0.8)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 42.8032983839151 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fraction vascular(0.13)
		V_org: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Volume(0.0346585412015507 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 5.30975156352275E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Hydraulic conductivity(1.53888888888889E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Hydraulic conductivity(1.53888888888889E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.0784831991258473
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|P (large endothelial pores)(5.30975156352275E-07 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fluid recirculation flow rate(5.48388198833307E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Lymph flow rate(3.21534660331426E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)(42.8032983839151 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 7008199289596.07
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Fluid recirculation flow rate(5.48388198833307E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Lymph flow rate(3.21534660331426E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|Surface area (plasma/interstitial)(42.8032983839151 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 66.3261490263844 [dm²]
	Formula: Aeff / MicrovilliFactor
		Aeff: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Effective surface area(1658.15372565961 [dm²])
		MicrovilliFactor: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Microvilli factor(25)

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor * P_int_scalefactor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|P_int_cell_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor * P_int_scalefactor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|P_cell_int_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|Surface area (interstitial/intracellular)(66.3261490263844 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|Surface area (interstitial/intracellular)(66.3261490263844 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (lipid)(0.06)
		f_proteins: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (protein)(0.08)
		f_water: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Vf (water)(0.8)

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 186.817003731648 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction vascular(0.13)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Volume(0.0305145851883218 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 37.6855127075774 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fraction vascular(0.13)
		V_org: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Volume(0.0305145851883218 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 5.30975156352275E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Hydraulic conductivity(1.53888888888889E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Hydraulic conductivity(1.53888888888889E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.0784831991258473
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|P (large endothelial pores)(5.30975156352275E-07 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fluid recirculation flow rate(4.82820044624977E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Lymph flow rate(2.8309029877006E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)(37.6855127075774 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 7008199289596.07
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Fluid recirculation flow rate(4.82820044624977E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Lymph flow rate(2.8309029877006E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|Surface area (plasma/interstitial)(37.6855127075774 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 18.1448764888336 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction vascular(0.13)
		V_org: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Volume(0.0146922076832661 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Hydraulic conductivity(1.53888888888889E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 5.30975156352275E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Hydraulic conductivity(1.53888888888889E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.0784831991258473
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|P (large endothelial pores)(5.30975156352275E-07 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fluid recirculation flow rate(2.32468910374989E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Lymph flow rate(1.36302736444844E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)(18.1448764888336 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 7008199289596.07
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fluid recirculation flow rate(2.32468910374989E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Lymph flow rate(1.36302736444844E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|Surface area (plasma/interstitial)(18.1448764888336 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 31.5453664128938 [dm²]
	Formula: Aeff / MicrovilliFactor
		Aeff: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Effective surface area(788.634160322344 [dm²])
		MicrovilliFactor: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Microvilli factor(25)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor * P_int_scalefactor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|P_int_cell_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor * P_int_scalefactor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|P_cell_int_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|Surface area (interstitial/intracellular)(31.5453664128938 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (lipid)(0.06)
		f_proteins: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (protein)(0.08)
		f_water: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Vf (water)(0.8)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|Surface area (interstitial/intracellular)(31.5453664128938 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 89.9489277226451 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Fraction vascular(0.13)
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Volume(0.0146922076832661 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 8.19858834678396 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction vascular(0.13)
		V_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Volume(0.00663853307431899 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Hydraulic conductivity(1.86944444444444E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 6.45029386687872E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Hydraulic conductivity(1.86944444444444E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.327874696713464
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|P (large endothelial pores)(6.45029386687872E-07 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fluid recirculation flow rate(4.98623511035952E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Lymph flow rate(3.19444618288292E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)(8.19858834678396 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 36407017847237.7
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fluid recirculation flow rate(4.98623511035952E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Lymph flow rate(3.19444618288292E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|Surface area (plasma/interstitial)(8.19858834678396 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 2.28204581730992 [dm²]
	Formula: Aeff / MicrovilliFactor
		Aeff: PBPK_model_human_Ab|Organism|Lumen|Caecum|Effective surface area(2.28204581730992 [dm²])
		MicrovilliFactor: PBPK_model_human_Ab|Organism|Lumen|Caecum|Microvilli factor(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor * P_int_scalefactor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|P_int_cell_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor * P_int_scalefactor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|P_cell_int_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|Surface area (interstitial/intracellular)(2.28204581730992 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|Surface area (interstitial/intracellular)(2.28204581730992 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (lipid)(0.06)
		f_proteins: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (protein)(0.08)
		f_water: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Vf (water)(0.8)

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 40.6425599582572 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Fraction vascular(0.13)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Volume(0.00663853307431899 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 74.5113631221917 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction vascular(0.13)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Volume(0.012170644492062 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 8.86293406514235 [dm²]
	Formula: Aeff / MicrovilliFactor
		Aeff: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Effective surface area(8.86293406514235 [dm²])
		MicrovilliFactor: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Microvilli factor(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor * P_int_scalefactor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|P_int_cell_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor * P_int_scalefactor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|P_cell_int_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Surface area (interstitial/intracellular)(8.86293406514235 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|Surface area (interstitial/intracellular)(8.86293406514235 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (lipid)(0.06)
		f_proteins: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (protein)(0.08)
		f_water: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Vf (water)(0.8)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 15.0307459476965 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fraction vascular(0.13)
		V_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Volume(0.012170644492062 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 6.45029386687872E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Hydraulic conductivity(1.86944444444444E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Hydraulic conductivity(1.86944444444444E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.327874696713464
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|P (large endothelial pores)(6.45029386687872E-07 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fluid recirculation flow rate(9.14143142809429E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Lymph flow rate(5.85648492003344E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)(15.0307459476965 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 36407017847237.7
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Fluid recirculation flow rate(9.14143142809429E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Lymph flow rate(5.85648492003344E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|Surface area (plasma/interstitial)(15.0307459476965 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 31.59941831152 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction vascular(0.12)
		V_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Volume(0.0277187879925614 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 6.45029386687872E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Hydraulic conductivity(1.86944444444444E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Hydraulic conductivity(1.86944444444444E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.355197588106253
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|P (large endothelial pores)(6.45029386687872E-07 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fluid recirculation flow rate(2.08197191093004E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Lymph flow rate(0.000133382142569294 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)(31.59941831152 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 39440936001174.1
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fluid recirculation flow rate(2.08197191093004E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Lymph flow rate(0.000133382142569294 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|Surface area (plasma/interstitial)(31.59941831152 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 156.646632206603 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Fraction vascular(0.12)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Volume(0.0277187879925614 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 13.6930569430801 [dm²]
	Formula: Aeff / MicrovilliFactor
		Aeff: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Effective surface area(13.6930569430801 [dm²])
		MicrovilliFactor: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Microvilli factor(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor * P_int_scalefactor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|P_int_cell_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor * P_int_scalefactor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|P_cell_int_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Surface area (interstitial/intracellular)(13.6930569430801 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|Surface area (interstitial/intracellular)(13.6930569430801 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (lipid)(0.06)
		f_proteins: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (protein)(0.08)
		f_water: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Vf (water)(0.8)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 6.6415380370092 [dm²]
	Formula: Aeff / MicrovilliFactor
		Aeff: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Effective surface area(6.6415380370092 [dm²])
		MicrovilliFactor: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Microvilli factor(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (lipid)(0.06)
		f_proteins: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (protein)(0.08)
		f_water: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Vf (water)(0.8)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor * P_int_scalefactor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|P_int_cell_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor * P_int_scalefactor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|P_cell_int_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Surface area (interstitial/intracellular)(6.6415380370092 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|Surface area (interstitial/intracellular)(6.6415380370092 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 78.3233161033013 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction vascular(0.12)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Volume(0.0138593939962807 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 15.79970915576 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fraction vascular(0.12)
		V_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Volume(0.0138593939962807 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.355197588106253
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|P (large endothelial pores)(6.45029386687872E-07 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fluid recirculation flow rate(1.04098595546502E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Lymph flow rate(6.66910712846469E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)(15.79970915576 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 6.45029386687872E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Hydraulic conductivity(1.86944444444444E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Hydraulic conductivity(1.86944444444444E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 39440936001174.1
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Fluid recirculation flow rate(1.04098595546502E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Lymph flow rate(6.66910712846469E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|Surface area (plasma/interstitial)(15.79970915576 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 8.21854246352471 [dm²]
	Formula: Aeff / MicrovilliFactor
		Aeff: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Effective surface area(8.21854246352471 [dm²])
		MicrovilliFactor: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Microvilli factor(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor * P_int_scalefactor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|P_int_cell_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor * P_int_scalefactor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|P_cell_int_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Surface area (interstitial/intracellular)(8.21854246352471 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|Surface area (interstitial/intracellular)(8.21854246352471 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (lipid)(0.06)
		f_proteins: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (protein)(0.08)
		f_water: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Vf (water)(0.8)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 62.9383790115814 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction vascular(0.08)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Volume(0.0167055195490884 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 12.6961948573072 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fraction vascular(0.08)
		V_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Volume(0.0167055195490884 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 6.45029386687872E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Hydraulic conductivity(1.86944444444444E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Hydraulic conductivity(1.86944444444444E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.53279638215938
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|P (large endothelial pores)(6.45029386687872E-07 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fluid recirculation flow rate(1.25475985703373E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Lymph flow rate(8.0386559137744E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)(12.6961948573072 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 59161404001761.2
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Fluid recirculation flow rate(1.25475985703373E-06 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Lymph flow rate(8.0386559137744E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|Surface area (plasma/interstitial)(12.6961948573072 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|Surface area (interstitial/intracellular)
	IsFixed: False
	Value: 3.84643425864822 [dm²]
	Formula: Aeff / MicrovilliFactor
		Aeff: PBPK_model_human_Ab|Organism|Lumen|Rectum|Effective surface area(3.84643425864822 [dm²])
		MicrovilliFactor: PBPK_model_human_Ab|Organism|Lumen|Rectum|Microvilli factor(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|P (intracellular->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_cell_int_factor * P_int_scalefactor
		P_cell_int_factor: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|P_cell_int_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|P (interstitial->intracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_int_cell_factor * P_int_scalefactor
		P_int_cell_factor: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|P_int_cell_factor(1)
		P_int_scalefactor: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)(0)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: (f_water + f_lipids * 10^LogMA + f_proteins * KProt) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (lipid)(0.06)
		f_proteins: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (protein)(0.08)
		f_water: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Vf (water)(0.8)

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|P_int_cell_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|P_cell_int_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|P*SA intracellular -> interstitial
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_cell_int * SA
		P_cell_int: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|P (intracellular->interstitial)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|Surface area (interstitial/intracellular)(3.84643425864822 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|P*SA interstitial -> intracellular
	IsFixed: False
	Value: 0 [l/min]
	Formula: P_int_cell * SA
		P_int_cell: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|P (interstitial->intracellular)(0 [dm/min])
		SA: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|Surface area (interstitial/intracellular)(3.84643425864822 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: fu/K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1|Partition coefficient (interstitial/water)
	IsFixed: False
	Value: 1.03909058791745
	Formula: fu/K_int_pls
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		K_int_pls: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1|Partition coefficient (interstitial/plasma)(0.96238)

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_bc|Surface area (blood cells/plasma)
	IsFixed: False
	Value: 25.6415618195332 [dm²]
	Formula: HCT * A_to_V_bc * 0.6 * V * f_vas
		f_vas: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction vascular(0.08)
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Volume(0.00680595240888785 [l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		A_to_V_bc: PBPK_model_human_Ab|Organism|Surface/Volume ratio (blood cells)(167000 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)
	IsFixed: False
	Value: 5.17252383075477 [dm²]
	Formula: k * f_vas_org * V_org
		f_vas_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fraction vascular(0.08)
		V_org: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Volume(0.00680595240888785 [l])
		k: PBPK_model_human_Ab|Organism|SA proportionality factor(9500 [1/dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|P (plasma<->interstitial)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P/2
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Reflection coefficient (large pores)
	IsFixed: False
	Value: 0.172692444072958
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Radius ratio (solute/large pores)(0.2136)

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|P (small endothelial pores)
	IsFixed: False
	Value: 1E-22 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* (1-alpha_l)*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Hydraulic conductivity(1.86944444444444E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Radius (small pores)(4.5E-08 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Partition coefficient (interstitial/plasma)
	IsFixed: False
	Value: 0.96238
	Formula: (f_water_int + f_proteins_int_to_pls * (1/fu - f_water_pls)) * fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		f_proteins_int_to_pls: PBPK_model_human_Ab|Organism|Protein ratio (interstial/plasma)(0.37)
		f_water_int: PBPK_model_human_Ab|Organism|Vf (water,interstitial)(0.935)
		f_water_pls: PBPK_model_human_Ab|Organism|Vf (water,plasma)(0.926)

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Peclet number (large pores)
	IsFixed: False
	Value: 0.53279638215938
	Formula: (J_iso+alpha_l*Q_lymph)*(1-sigma_l)/(P_endothelial_l*SA_pls_int)
		P_endothelial_l: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|P (large endothelial pores)(6.45029386687872E-07 [dm/min])
		sigma_l: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Reflection coefficient (large pores)(0.172692444072958)
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fluid recirculation flow rate(5.11198460273E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Lymph flow rate(3.27500796487105E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)(5.17252383075477 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Peclet number (small pores)
	IsFixed: False
	Value: 59161404001761.2
	Formula: (-J_iso+(1-alpha_l)*Q_lymph)*(1-sigma_s)/(P_endothelial_s*SA_pls_int)
		P_endothelial_s: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|P (small endothelial pores)(1E-22 [dm/min])
		sigma_s: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Reflection coefficient (small pores)(0.999)
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Flow fraction via large pores(0.05)
		J_iso: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Fluid recirculation flow rate(5.11198460273E-07 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Lymph flow rate(3.27500796487105E-05 [l/min])
		SA_pls_int: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|Surface area (plasma/interstitial)(5.17252383075477 [dm²])

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Radius ratio (solute/large pores)
	IsFixed: False
	Value: 0.2136
	Formula: a_e / r_l
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Radius (large pores)(2.5E-07 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Reflection coefficient (small pores)
	IsFixed: False
	Value: 0.999
	Formula: gamma<1 ? 1-(1-gamma)^2*(2-(1-gamma)^2)*(1-gamma/3)/(1-gamma/3+2/3*gamma^2) : 0.999
		gamma: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Radius ratio (solute/small pores)(1.18666666666667)

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Radius ratio (solute/small pores)
	IsFixed: False
	Value: 1.18666666666667
	Formula: a_e / r_s
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		r_s: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Radius (small pores)(4.5E-08 [dm])

Parameter: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|P (large endothelial pores)
	IsFixed: False
	Value: 6.45029386687872E-07 [dm/min]
	Formula: gamma<1 ? (1-gamma)^4.5/(1-0.3956*gamma+1.0616*gamma^2)* alpha_l*8*Lp/(r)^2 * RT/(6*Pi*Na*a_e) : 1e-22
		gamma: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1|Radius ratio (solute/large pores)(0.2136)
		a_e: PBPK_model_human_Ab|CDA1|Radius (solute)(5.34E-08 [dm])
		alpha_l: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Flow fraction via large pores(0.05)
		Lp: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Hydraulic conductivity(1.86944444444444E-10 [l/min/(kg*dm/min²)])
		r: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Radius (large pores)(2.5E-07 [dm])
		Na: PBPK_model_human_Ab|Organism|Na(6.022E+17 [1/µmol])
		RT: PBPK_model_human_Ab|Organism|R*T(928.8 [(kg*dm/min²)*dm/µmol])

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		C_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Blood flow rate(0.0453597189755988 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Lymph flow rate(1.52029975265403E-05 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|Duodenum_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		C_bc: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Blood flow rate(0.0453597189755988 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_trans*Aeff*(P_int_trans_lum_cell_factor*min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		Aeff: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Effective surface area(697.637922302124 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Liquid(0.0120515229563923 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_trans: PBPK_model_human_Ab|CDA1|Intestinal permeability (transcellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		P_int_trans_cell_lum_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|P_int_trans_cell_lum_factor(1)
		P_int_trans_lum_cell_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|P_int_trans_lum_cell_factor(1)
		Solubility: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_trans: PBPK_model_human_Ab|Organism|Lumen|Transcellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|P_int_trans_cell_lum_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|P_int_trans_lum_cell_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|Duodenum|pH(6)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|Duodenum|pH(6)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|Duodenum|pH(6)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_cell_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: P_1
		P_1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|DrugAbsorption_trans|ProcessRate(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|DrugAbsorption_trans|ProcessRate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])
	Tags: DrugAbsorption_trans, ProcessRate, CDA1, Lumen_duo_Duodenum_cell, Passive
Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_pls|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_para*Aeff*(min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0
		Aeff: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Effective surface area(697.637922302124 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Liquid(0.0120515229563923 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_para: PBPK_model_human_Ab|CDA1|Intestinal permeability (paracellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_para: PBPK_model_human_Ab|Organism|Lumen|Paracellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_pls|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_pls|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: P_1
		P_1: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_pls|CDA1|DrugAbsorption_para|ProcessRate(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_pls|CDA1|DrugAbsorption_para|ProcessRate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_pls|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])
	Tags: DrugAbsorption_para, ProcessRate, CDA1, Lumen_duo_Duodenum_pls, Passive
Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_pls|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_para*Aeff*(min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0
		Aeff: PBPK_model_human_Ab|Organism|Lumen|Caecum|Effective surface area(2.28204581730992 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Caecum|Liquid(0.00130513175379201 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_para: PBPK_model_human_Ab|CDA1|Intestinal permeability (paracellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_para: PBPK_model_human_Ab|Organism|Lumen|Paracellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_pls|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_pls|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_pls|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_pls|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_pls|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_para*Aeff*(min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0
		Aeff: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Effective surface area(13.6930569430801 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Liquid(0.00454008377608023 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_para: PBPK_model_human_Ab|CDA1|Intestinal permeability (paracellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_para: PBPK_model_human_Ab|Organism|Lumen|Paracellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_para*Aeff*(min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0
		Aeff: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Effective surface area(8.21854246352471 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Liquid(0.00193383417529163 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_para: PBPK_model_human_Ab|CDA1|Intestinal permeability (paracellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_para: PBPK_model_human_Ab|Organism|Lumen|Paracellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Blood flow rate(0.0468125781142232 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Blood flow rate(0.0468125781142232 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Lymph flow rate(6.66910712846469E-05 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|pH(6.6)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|pH(6.6)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|pH(6.6)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: P_1
		P_1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|DrugAbsorption_trans|ProcessRate(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_trans*Aeff*(P_int_trans_lum_cell_factor*min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		Aeff: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Effective surface area(6.6415380370092 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Liquid(0.00156276289737139 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_trans: PBPK_model_human_Ab|CDA1|Intestinal permeability (transcellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		P_int_trans_cell_lum_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|P_int_trans_cell_lum_factor(1)
		P_int_trans_lum_cell_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|P_int_trans_lum_cell_factor(1)
		Solubility: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_trans: PBPK_model_human_Ab|Organism|Lumen|Transcellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|P_int_trans_cell_lum_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|P_int_trans_lum_cell_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_lum_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|DrugAbsorption_trans|ProcessRate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])
	Tags: DrugAbsorption_trans, ProcessRate, CDA1, Lumen_coldesc_ColonDescendens_cell, Passive
Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_pls|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_pls|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_para*Aeff*(min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0
		Aeff: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Effective surface area(6.6415380370092 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Liquid(0.00156276289737139 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_para: PBPK_model_human_Ab|CDA1|Intestinal permeability (paracellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_para: PBPK_model_human_Ab|Organism|Lumen|Paracellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_pls|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Blood flow rate(0.0624167708189642 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Blood flow rate(0.0263320751892505 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Lymph flow rate(8.0386559137744E-05 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: P_1
		P_1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|DrugAbsorption_trans|ProcessRate(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_trans*Aeff*(P_int_trans_lum_cell_factor*min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		Aeff: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Effective surface area(13.6930569430801 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Liquid(0.00454008377608023 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_trans: PBPK_model_human_Ab|CDA1|Intestinal permeability (transcellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		P_int_trans_cell_lum_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|P_int_trans_cell_lum_factor(1)
		P_int_trans_lum_cell_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|P_int_trans_lum_cell_factor(1)
		Solubility: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_trans: PBPK_model_human_Ab|Organism|Lumen|Transcellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|P_int_trans_cell_lum_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|P_int_trans_lum_cell_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|pH(5.7)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|pH(5.7)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|pH(5.7)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|DrugAbsorption_trans|ProcessRate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])
	Tags: DrugAbsorption_trans, ProcessRate, CDA1, Lumen_coltrans_ColonTransversum_cell, Passive
Parameter: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Blood flow rate(0.0263320751892505 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Blood flow rate(0.0302896885639905 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Blood flow rate(0.0302896885639905 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Lymph flow rate(5.85648492003344E-05 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|pH(5.6)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|pH(5.6)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|pH(5.6)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: P_1
		P_1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|DrugAbsorption_trans|ProcessRate(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_trans*Aeff*(P_int_trans_lum_cell_factor*min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		Aeff: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Effective surface area(8.86293406514235 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Liquid(0.00364955582686276 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_trans: PBPK_model_human_Ab|CDA1|Intestinal permeability (transcellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		P_int_trans_cell_lum_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|P_int_trans_cell_lum_factor(1)
		P_int_trans_lum_cell_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|P_int_trans_lum_cell_factor(1)
		Solubility: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_trans: PBPK_model_human_Ab|Organism|Lumen|Transcellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|P_int_trans_cell_lum_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|P_int_trans_lum_cell_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_lum_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|DrugAbsorption_trans|ProcessRate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])
	Tags: DrugAbsorption_trans, ProcessRate, CDA1, Lumen_colasc_ColonAscendens_cell, Passive
Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_pls|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_para*Aeff*(min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_para ? fu*DrugMucosa : 0)) : 0
		Aeff: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Effective surface area(8.86293406514235 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Liquid(0.00364955582686276 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_para: PBPK_model_human_Ab|CDA1|Intestinal permeability (paracellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_para: PBPK_model_human_Ab|Organism|Lumen|Paracellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_pls|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_pls|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_bc_PortalVein_bc|CDA1|Mass transfer rate (mucosa to portal vein blood cells)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: Q*HCT*C_bc
		C_bc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Blood flow rate(0.0165221093405974 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Blood flow rate(0.0165221093405974 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Lymph flow rate(3.19444618288292E-05 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|P_int_trans_cell_lum_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_trans*Aeff*(P_int_trans_lum_cell_factor*min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		Aeff: PBPK_model_human_Ab|Organism|Lumen|Caecum|Effective surface area(2.28204581730992 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Caecum|Liquid(0.00130513175379201 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_trans: PBPK_model_human_Ab|CDA1|Intestinal permeability (transcellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		P_int_trans_cell_lum_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|P_int_trans_cell_lum_factor(1)
		P_int_trans_lum_cell_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|P_int_trans_lum_cell_factor(1)
		Solubility: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_trans: PBPK_model_human_Ab|Organism|Lumen|Transcellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|Caecum|pH(5.7)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|Caecum|pH(5.7)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|Caecum|pH(5.7)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|P_int_trans_lum_cell_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|pKa_pH_WS_lum_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: P_1
		P_1: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|DrugAbsorption_trans|ProcessRate(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|DrugAbsorption_trans|ProcessRate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])
	Tags: DrugAbsorption_trans, ProcessRate, CDA1, Lumen_cae_Caecum_cell, Passive
Parameter: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_PortalVein_pls|CDA1|Mass transfer rate (mucosa to portal vein plasma)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: (Q*(1-HCT)-Q_lymph)*C_pls
		C_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1|Concentration(0 [µmol/l])
		Q: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Blood flow rate(0.0624167708189642 [l/min])
		Q_lymph: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Lymph flow rate(0.000133382142569294 [l/min])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|Drug absorption rate (lumen to mucosa)
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: OralApplicationsEnabled ? P_int_trans*Aeff*(P_int_trans_lum_cell_factor*min(Solubility/ MW ;DrugLiquid/(Liquid))-(NOT SinkCondition_trans ? P_int_trans_cell_lum_factor*fu/K_cell_pls*DrugMucosa : 0)) : 0
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)
		Aeff: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Effective surface area(8.21854246352471 [dm²])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Liquid(0.00193383417529163 [l])
		DrugLiquid: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1(0 [µmol])
		DrugMucosa: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		P_int_trans: PBPK_model_human_Ab|CDA1|Intestinal permeability (transcellular)(0 [dm/min])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		P_int_trans_cell_lum_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|P_int_trans_cell_lum_factor(1)
		P_int_trans_lum_cell_factor: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|P_int_trans_lum_cell_factor(1)
		Solubility: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|Solubility(0.000999 [kg/l])
		OralApplicationsEnabled: PBPK_model_human_Ab|Organism|Lumen|OralApplicationsEnabled(1)
		SinkCondition_trans: PBPK_model_human_Ab|Organism|Lumen|Transcellular absorption sink condition(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|P_int_trans_cell_lum_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|P_int_trans_lum_cell_factor
	IsFixed: False
	Value: 1
	Formula: UsePenaltyFactor ? K1+ (K2 +K3 +K4)* base ^ 1 + K5* base ^ max(CT0+CT1;-CT0-CT1) +K6* base ^ max(CT0+CT2;-CT0-CT2) +K7* base ^ max(CT2+CT1;-CT2-CT1) +K8* base ^ max(CT0+CT1+CT2;-CT0-CT1-CT2) : 1
		K1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_K1(1)
		K2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_K2(0)
		K3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_K3(0)
		K4: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_K4(0)
		K5: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_K5(0)
		K6: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_K6(0)
		K7: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_K7(0)
		K8: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_K8(0)
		base: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor(0.1)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		UsePenaltyFactor: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|Partition coefficient (intracellular/plasma)
	IsFixed: False
	Value: 0.813002222792937
	Formula: K_cell_pls
		K_cell_pls: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|Partition coefficient (intracellular/plasma)(0.813002222792937)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|Partition coefficient (intracellular/water)
	IsFixed: False
	Value: 1.2300089372015
	Formula: K_water_cell
		K_water_cell: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1|Partition coefficient (intracellular/water)(1.2300089372015)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|pH(7.3)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|pH(6.6)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|pH(6.6)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		pH: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|pH(6.6)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_cell_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|Sum of active process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|Sum of passive process rates
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: P_1
		P_1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|DrugAbsorption_trans|ProcessRate(0 [µmol/min])

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F1(1)
		F2: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F2(1)
		F3: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|pKa_pH_WS_lum_F3(1)

Parameter: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|DrugAbsorption_trans|ProcessRate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: DrugAbsorptionLumenToMucosaRate
		DrugAbsorptionLumenToMucosaRate: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1|Drug absorption rate (lumen to mucosa)(0 [µmol/min])
	Tags: DrugAbsorption_trans, ProcessRate, CDA1, Lumen_colsigm_ColonSigmoid_cell, Passive
Parameter: PBPK_model_human_Ab|CDA1|P (blood cells->plasma)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_rbc_pls_factor
		P_rbc_pls_factor: PBPK_model_human_Ab|CDA1|P_bc_pls_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|CDA1|Mucosa permeability scale factor (transcellular)
	IsFixed: False
	Value: 0
	Formula: P_int_trans_default >0 ? P_int_trans / P_int_trans_default : 0
		P_int_trans_default: PBPK_model_human_Ab|CDA1|Default Intestinal permeability (transcellular)(0 [dm/min])
		P_int_trans: PBPK_model_human_Ab|CDA1|Intestinal permeability (transcellular)(0 [dm/min])

Parameter: PBPK_model_human_Ab|CDA1|P (plasma->blood cells)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: P * P_pls_rbc_factor
		P_pls_rbc_factor: PBPK_model_human_Ab|CDA1|P_pls_bc_factor(1)
		P: PBPK_model_human_Ab|CDA1|Permeability(0 [dm/min])

Parameter: PBPK_model_human_Ab|CDA1|P_bc_pls_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|CDA1|P_pls_bc_factor
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|CDA1|Partition coefficient (blood cells/plasma)
	IsFixed: False
	Value: 0.677819142596308
	Formula: (f_water_rbc + f_lipids_rbc * 10^LogMA + f_proteins_rbc * KProt)*fu
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		f_lipids_rbc: PBPK_model_human_Ab|Organism|Vf (lipid, blood cells)(0.005)
		f_proteins_rbc: PBPK_model_human_Ab|Organism|Vf (protein,blood cells)(0.325)
		f_water_rbc: PBPK_model_human_Ab|Organism|Vf (water,blood cells)(0.625)

Parameter: PBPK_model_human_Ab|CDA1|Intestinal permeability (transcellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: 10 ^ (m * log10 (P_int_InVitro) + b)
		b: PBPK_model_human_Ab|CDA1|Parameter b for correlation of intestinal permeability (transcellular)(0)
		m: PBPK_model_human_Ab|CDA1|Parameter m for correlation of intestinal permeability (transcellular)(1)
		P_int_InVitro: PBPK_model_human_Ab|CDA1|Specific intestinal permeability (transcellular)(0 [dm/min])

Parameter: PBPK_model_human_Ab|CDA1|Intestinal permeability (paracellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|CDA1|Default Intestinal permeability (transcellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: 10 ^ (m * log10 (P_int_InVitro) + b)
		P_int_InVitro: PBPK_model_human_Ab|CDA1|Calculated specific intestinal permeability (transcellular)(0 [dm/min])
		b: PBPK_model_human_Ab|CDA1|Parameter b for correlation of intestinal permeability (transcellular)(0)
		m: PBPK_model_human_Ab|CDA1|Parameter m for correlation of intestinal permeability (transcellular)(1)

Parameter: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)
	IsFixed: False
	Value: 1
	Formula: 1 / (1 + (BindingPartner = Albumin ? AlbuminOntgenyFactor : (BindingPartner = Agp ? AgpOntogenyFactor : 1) ) * (1 - fu_ref) / fu_ref) * PlasmaProteinScaleFactor
		Agp: PBPK_model_human_Ab|CDA1|BP_AGP(0)
		Albumin: PBPK_model_human_Ab|CDA1|BP_ALBUMIN(1)
		fu_ref: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma, reference value)(1)
		BindingPartner: PBPK_model_human_Ab|CDA1|Plasma protein binding partner(1)
		AlbuminOntgenyFactor: PBPK_model_human_Ab|Organism|Ontogeny factor (albumin)(1)
		AgpOntogenyFactor: PBPK_model_human_Ab|Organism|Ontogeny factor (alpha1-acid glycoprotein)(1)
		PlasmaProteinScaleFactor: PBPK_model_human_Ab|Organism|Plasma protein scale factor(1)

Parameter: PBPK_model_human_Ab|CDA1|Blood/Plasma concentration ratio
	IsFixed: False
	Value: 0.848574997020265
	Formula: (f_water_rbc + f_lipids_rbc * 10^LogP + f_proteins_rbc * KProt) * fu * HCT - HCT + 1
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		LogP: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])
		KProt: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)(0.162520284911717)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)
		f_lipids_rbc: PBPK_model_human_Ab|Organism|Vf (lipid, blood cells)(0.005)
		f_proteins_rbc: PBPK_model_human_Ab|Organism|Vf (protein,blood cells)(0.325)
		f_water_rbc: PBPK_model_human_Ab|Organism|Vf (water,blood cells)(0.625)

Parameter: PBPK_model_human_Ab|CDA1|Plasma protein binding partner
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_K6
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*(1-F3)
		F1: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F1(1)
		F2: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F2(1)
		F3: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F3(1)

Parameter: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_K7
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F1(1)
		F2: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F2(1)
		F3: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F3(1)

Parameter: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_K8
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*(1-F3)
		F1: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F1(1)
		F2: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F2(1)
		F3: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F3(1)

Parameter: PBPK_model_human_Ab|CDA1|pKa_ThreeAcids_0
	IsFixed: False
	Value: 0
	Formula: IsTriproticAcid ? Min (pKa_0; Min (pKa_1; pKa_2)) : 0
		IsTriproticAcid: PBPK_model_human_Ab|CDA1|Is triprotic acid(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)

Parameter: PBPK_model_human_Ab|CDA1|pKa_ThreeAcids_1
	IsFixed: False
	Value: 0
	Formula: IsTriproticAcid ? (pKa_0 <= pKa_Acid_0 ? min(pKa_1; pKa_2) : (pKa_0 >= pKa_Acid_2 ? max(pKa_1; pKa_2) : pKa_0)) : 0
		IsTriproticAcid: PBPK_model_human_Ab|CDA1|Is triprotic acid(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pKa_Acid_0: PBPK_model_human_Ab|CDA1|pKa_Acid_0(0)
		pKa_Acid_2: PBPK_model_human_Ab|CDA1|pKa_Acid_2(0)

Parameter: PBPK_model_human_Ab|CDA1|pKa_ThreeBases_0
	IsFixed: False
	Value: 0
	Formula: IsTriproticBase ? Min (pKa_0; Min (pKa_1; pKa_2)) : 0
		IsTriproticBase: PBPK_model_human_Ab|CDA1|Is triprotic base(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)

Parameter: PBPK_model_human_Ab|CDA1|pKa_ThreeBases_1
	IsFixed: False
	Value: 0
	Formula: IsTriproticBase ? (pKa_0 <= pKa_Base_0 ? min(pKa_1; pKa_2) : (pKa_0 >= pKa_Base_2 ? max(pKa_1; pKa_2) : pKa_0)) : 0
		IsTriproticBase: PBPK_model_human_Ab|CDA1|Is triprotic base(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pKa_Base_0: PBPK_model_human_Ab|CDA1|pKa_Base_0(0)
		pKa_Base_2: PBPK_model_human_Ab|CDA1|pKa_Base_2(0)

Parameter: PBPK_model_human_Ab|CDA1|pKa_TwoAcids_0
	IsFixed: False
	Value: 0
	Formula: pKa_Acids_Count=2 ? (CT0 != CT_ACID ? Min(pKa_1;pKa_2) : (CT1 != CT_ACID ? Min(pKa_0;pKa_2) : Min(pKa_0;pKa_1))) : 0
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_ACID: PBPK_model_human_Ab|CDA1|CT_ACID(-1)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pKa_Acids_Count: PBPK_model_human_Ab|CDA1|pKa_Acids_Count(0)

Parameter: PBPK_model_human_Ab|CDA1|pKa_TwoAcids_1
	IsFixed: False
	Value: 0
	Formula: pKa_Acids_Count=2 ? (CT0 != CT_ACID ? Max(pKa_1;pKa_2) : (CT1 != CT_ACID ? Max(pKa_0;pKa_2) : Max(pKa_0;pKa_1))) : 0
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_ACID: PBPK_model_human_Ab|CDA1|CT_ACID(-1)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pKa_Acids_Count: PBPK_model_human_Ab|CDA1|pKa_Acids_Count(0)

Parameter: PBPK_model_human_Ab|CDA1|pKa_TwoBases_1
	IsFixed: False
	Value: 0
	Formula: pKa_Bases_Count=2 ? (CT0 != CT_BASE ? Max(pKa_1;pKa_2) : (CT1 != CT_BASE ? Max(pKa_0;pKa_2) : Max(pKa_0;pKa_1))) : 0
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_BASE: PBPK_model_human_Ab|CDA1|CT_BASE(1)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pKa_Bases_Count: PBPK_model_human_Ab|CDA1|pKa_Bases_Count(0)

Parameter: PBPK_model_human_Ab|CDA1|Solubility_pKa_pH_Factor
	IsFixed: False
	Value: 1
	Formula: K1+K2/base^(CT0^2)+K3/base^(CT1^2)+K4/base^(CT2^2)+K5/base^max(CT0+CT1;-CT0-CT1)+K6/base^max(CT0+CT2;-CT0-CT2)+K7/base^max(CT1+CT2;-CT1-CT2)+K8/base^max(CT0+CT1+CT2;-CT0-CT1-CT2)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		K1: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_K1(1)
		K2: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_K2(0)
		K3: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_K3(0)
		K4: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_K4(0)
		K5: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_K5(0)
		K6: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_K6(0)
		K7: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_K7(0)
		K8: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_K8(0)
		base: PBPK_model_human_Ab|CDA1|Solubility gain per charge(1000)

Parameter: PBPK_model_human_Ab|CDA1|Total drug mass
	IsFixed: False
	Value: 9.73333334705646 [µmol]
	Formula: P_1 + P_2
		P_1: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|ProtocolSchemaItem|DrugMass(0.584000000823388 [µmol])
		P_2: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|ProtocolSchemaItem|DrugMass(9.14933334623307 [µmol])

Parameter: PBPK_model_human_Ab|CDA1|Total oral drug mass
	IsFixed: False
	Value: 0 [µmol]
	Formula: 0

Parameter: PBPK_model_human_Ab|CDA1|pKa_TwoBases_0
	IsFixed: False
	Value: 0
	Formula: pKa_Bases_Count=2 ? (CT0 != CT_BASE ? Min(pKa_1;pKa_2) : (CT1 != CT_BASE ? Min(pKa_0;pKa_2) : Min(pKa_0;pKa_1))) : 0
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_BASE: PBPK_model_human_Ab|CDA1|CT_BASE(1)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pKa_Bases_Count: PBPK_model_human_Ab|CDA1|pKa_Bases_Count(0)

Parameter: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_K3
	IsFixed: False
	Value: 0
	Formula: F1*(1-F2)*F3
		F1: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F1(1)
		F2: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F2(1)
		F3: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F3(1)

Parameter: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_K5
	IsFixed: False
	Value: 0
	Formula: (1-F1)*(1-F2)*F3
		F1: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F1(1)
		F2: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F2(1)
		F3: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F3(1)

Parameter: PBPK_model_human_Ab|CDA1|base_For_logD_Factor
	IsFixed: False
	Value: 0.001
	Formula: 0.001

Parameter: PBPK_model_human_Ab|CDA1|base_For_KaPL_Factor
	IsFixed: False
	Value: 20
	Formula: 20

Parameter: PBPK_model_human_Ab|CDA1|base_For_P_cell_Factor
	IsFixed: False
	Value: 0.001
	Formula: 0.001

Parameter: PBPK_model_human_Ab|CDA1|base_For_Pint_Factor
	IsFixed: False
	Value: 0.1
	Formula: 0.1

Parameter: PBPK_model_human_Ab|CDA1|BP_AGP
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|CDA1|BP_ALBUMIN
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|CDA1|BP_UNKNOWN
	IsFixed: False
	Value: 2
	Formula: 2

Parameter: PBPK_model_human_Ab|CDA1|Br
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|CDA1|Calculated specific intestinal permeability (transcellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: IsSmallMolecule ? 266 * (MWEff * 1E9) ^ ( - 4.5) * 10^LogMA * 60 *1E-1 : 0
		MWEff: PBPK_model_human_Ab|CDA1|Effective molecular weight(0.00015 [kg/µmol])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])

Parameter: PBPK_model_human_Ab|CDA1|Cl
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|CDA1|Compound type 0
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|CDA1|CT_ACID
	IsFixed: False
	Value: -1
	Formula: -1

Parameter: PBPK_model_human_Ab|CDA1|pKa_Base_2
	IsFixed: False
	Value: 0
	Formula: IsTriproticBase ? Max (pKa_0; Max (pKa_1; pKa_2)) : 0
		IsTriproticBase: PBPK_model_human_Ab|CDA1|Is triprotic base(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)

Parameter: PBPK_model_human_Ab|CDA1|Molecular weight
	IsFixed: False
	Value: 0.00015 [kg/µmol]
	Formula: 0.00015

Parameter: PBPK_model_human_Ab|CDA1|pKa value 0
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|CDA1|pKa value 1
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|CDA1|pKa value 2
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|CDA1|pKa_Acid_0
	IsFixed: False
	Value: 0
	Formula: pKa_OneAcid_0+pKa_TwoAcids_0+pKa_ThreeAcids_0
		pKa_OneAcid_0: PBPK_model_human_Ab|CDA1|pKa_OneAcid_0(0)
		pKa_ThreeAcids_0: PBPK_model_human_Ab|CDA1|pKa_ThreeAcids_0(0)
		pKa_TwoAcids_0: PBPK_model_human_Ab|CDA1|pKa_TwoAcids_0(0)

Parameter: PBPK_model_human_Ab|CDA1|pKa_Acid_1
	IsFixed: False
	Value: 0
	Formula: pKa_TwoAcids_1+pKa_ThreeAcids_1
		pKa_ThreeAcids_1: PBPK_model_human_Ab|CDA1|pKa_ThreeAcids_1(0)
		pKa_TwoAcids_1: PBPK_model_human_Ab|CDA1|pKa_TwoAcids_1(0)

Parameter: PBPK_model_human_Ab|CDA1|pKa_Acid_2
	IsFixed: False
	Value: 0
	Formula: IsTriproticAcid ? Max (pKa_0; Max (pKa_1; pKa_2)) : 0
		IsTriproticAcid: PBPK_model_human_Ab|CDA1|Is triprotic acid(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)

Parameter: PBPK_model_human_Ab|CDA1|pKa_Acids_Count
	IsFixed: False
	Value: 0
	Formula: (CT0 = CT_ACID ? 1 : 0) + (CT1 = CT_ACID ? 1 : 0) + (CT2 = CT_ACID ? 1 : 0)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_ACID: PBPK_model_human_Ab|CDA1|CT_ACID(-1)

Parameter: PBPK_model_human_Ab|CDA1|Compound type 1
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|CDA1|pKa_Base_1
	IsFixed: False
	Value: 0
	Formula: pKa_TwoBases_1+pKa_ThreeBases_1
		pKa_ThreeBases_1: PBPK_model_human_Ab|CDA1|pKa_ThreeBases_1(0)
		pKa_TwoBases_1: PBPK_model_human_Ab|CDA1|pKa_TwoBases_1(0)

Parameter: PBPK_model_human_Ab|CDA1|Is triprotic base
	IsFixed: False
	Value: 0
	Formula: pKa_Acids_Count=0 & pKa_Bases_Count = 3 ? 1 : 0
		pKa_Acids_Count: PBPK_model_human_Ab|CDA1|pKa_Acids_Count(0)
		pKa_Bases_Count: PBPK_model_human_Ab|CDA1|pKa_Bases_Count(0)

Parameter: PBPK_model_human_Ab|CDA1|pKa_Bases_Count
	IsFixed: False
	Value: 0
	Formula: (CT0 = CT_BASE ? 1 : 0) + (CT1 = CT_BASE ? 1 : 0) + (CT2 = CT_BASE ? 1 : 0)
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_BASE: PBPK_model_human_Ab|CDA1|CT_BASE(1)

Parameter: PBPK_model_human_Ab|CDA1|pKa_OneAcid_0
	IsFixed: False
	Value: 0
	Formula: pKa_Acids_Count=1 ? (CT0=CT_ACID ? pKa_0 : (CT1=CT_ACID ? pKa_1 : pKa_2)) : 0
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_ACID: PBPK_model_human_Ab|CDA1|CT_ACID(-1)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pKa_Acids_Count: PBPK_model_human_Ab|CDA1|pKa_Acids_Count(0)

Parameter: PBPK_model_human_Ab|CDA1|pKa_OneBase_0
	IsFixed: False
	Value: 0
	Formula: pKa_Bases_Count=1 ? (CT0=CT_BASE ? pKa_0 : (CT1=CT_BASE ? pKa_1 : pKa_2)) : 0
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_BASE: PBPK_model_human_Ab|CDA1|CT_BASE(1)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pKa_Bases_Count: PBPK_model_human_Ab|CDA1|pKa_Bases_Count(0)

Parameter: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F1
	IsFixed: False
	Value: 1
	Formula: CT0 != CT_NEUTRAL ?  1/(1+10^(CT0*(pKa_0-pH))) : 1
		CT0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pH: PBPK_model_human_Ab|CDA1|Reference pH(7)

Parameter: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F2
	IsFixed: False
	Value: 1
	Formula: CT1 != CT_NEUTRAL ?  1/(1+10^(CT1*(pKa_1-pH))) : 1
		CT1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pH: PBPK_model_human_Ab|CDA1|Reference pH(7)

Parameter: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F3
	IsFixed: False
	Value: 1
	Formula: CT2 != CT_NEUTRAL ?  1/(1+10^(CT2*(pKa_2-pH))) : 1
		CT2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		CT_NEUTRAL: PBPK_model_human_Ab|CDA1|CT_NEUTRAL(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)
		pH: PBPK_model_human_Ab|CDA1|Reference pH(7)

Parameter: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_K1
	IsFixed: False
	Value: 1
	Formula: F1*F2*F3
		F1: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F1(1)
		F2: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F2(1)
		F3: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F3(1)

Parameter: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_K2
	IsFixed: False
	Value: 0
	Formula: (1-F1)*F2*F3
		F1: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F1(1)
		F2: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F2(1)
		F3: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F3(1)

Parameter: PBPK_model_human_Ab|CDA1|pKa_Base_0
	IsFixed: False
	Value: 0
	Formula: pKa_OneBase_0+pKa_TwoBases_0+pKa_ThreeBases_0
		pKa_OneBase_0: PBPK_model_human_Ab|CDA1|pKa_OneBase_0(0)
		pKa_ThreeBases_0: PBPK_model_human_Ab|CDA1|pKa_ThreeBases_0(0)
		pKa_TwoBases_0: PBPK_model_human_Ab|CDA1|pKa_TwoBases_0(0)

Parameter: PBPK_model_human_Ab|CDA1|Is diprotic base monoprotic acid
	IsFixed: False
	Value: 0
	Formula: pKa_Acids_Count=1 & pKa_Bases_Count = 2 ? 1 : 0
		pKa_Acids_Count: PBPK_model_human_Ab|CDA1|pKa_Acids_Count(0)
		pKa_Bases_Count: PBPK_model_human_Ab|CDA1|pKa_Bases_Count(0)

Parameter: PBPK_model_human_Ab|CDA1|CT_BASE
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|CDA1|CT_NEUTRAL
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|CDA1|Effective molecular weight
	IsFixed: False
	Value: 0.00015 [kg/µmol]
	Formula: MW - F * 0.000000017 - Cl * 0.000000022 - Br * 0.000000062 - I * 0.000000098
		Br: PBPK_model_human_Ab|CDA1|Br(0)
		Cl: PBPK_model_human_Ab|CDA1|Cl(0)
		F: PBPK_model_human_Ab|CDA1|F(0)
		I: PBPK_model_human_Ab|CDA1|I(0)
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])

Parameter: PBPK_model_human_Ab|CDA1|F
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|CDA1|Has halogens
	IsFixed: False
	Value: 0
	Formula: Br + Chlor + F + I > 0
		Br: PBPK_model_human_Ab|CDA1|Br(0)
		Chlor: PBPK_model_human_Ab|CDA1|Cl(0)
		F: PBPK_model_human_Ab|CDA1|F(0)
		I: PBPK_model_human_Ab|CDA1|I(0)

Parameter: PBPK_model_human_Ab|CDA1|I
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|CDA1|Is diprotic base
	IsFixed: False
	Value: 0
	Formula: pKa_Acids_Count=0 & pKa_Bases_Count = 2 ? 1 : 0
		pKa_Acids_Count: PBPK_model_human_Ab|CDA1|pKa_Acids_Count(0)
		pKa_Bases_Count: PBPK_model_human_Ab|CDA1|pKa_Bases_Count(0)

Parameter: PBPK_model_human_Ab|CDA1|Is floating in lumen
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|CDA1|Is monoprotic acid
	IsFixed: False
	Value: 0
	Formula: pKa_Acids_Count=1 & pKa_Bases_Count = 0 ? 1 : 0
		pKa_Acids_Count: PBPK_model_human_Ab|CDA1|pKa_Acids_Count(0)
		pKa_Bases_Count: PBPK_model_human_Ab|CDA1|pKa_Bases_Count(0)

Parameter: PBPK_model_human_Ab|CDA1|Is monoprotic base
	IsFixed: False
	Value: 0
	Formula: pKa_Acids_Count=0 & pKa_Bases_Count = 1 ? 1 : 0
		pKa_Acids_Count: PBPK_model_human_Ab|CDA1|pKa_Acids_Count(0)
		pKa_Bases_Count: PBPK_model_human_Ab|CDA1|pKa_Bases_Count(0)

Parameter: PBPK_model_human_Ab|CDA1|Is monoprotic base diprotic acid
	IsFixed: False
	Value: 0
	Formula: pKa_Acids_Count=2 & pKa_Bases_Count = 1 ? 1 : 0
		pKa_Acids_Count: PBPK_model_human_Ab|CDA1|pKa_Acids_Count(0)
		pKa_Bases_Count: PBPK_model_human_Ab|CDA1|pKa_Bases_Count(0)

Parameter: PBPK_model_human_Ab|CDA1|Is monoprotic base monoprotic acid
	IsFixed: False
	Value: 0
	Formula: pKa_Acids_Count=1 & pKa_Bases_Count = 1 ? 1 : 0
		pKa_Acids_Count: PBPK_model_human_Ab|CDA1|pKa_Acids_Count(0)
		pKa_Bases_Count: PBPK_model_human_Ab|CDA1|pKa_Bases_Count(0)

Parameter: PBPK_model_human_Ab|CDA1|Is neutral
	IsFixed: False
	Value: 1
	Formula: CT_0 = 0 AND CT_1 = 0 AND CT_2 = 0
		CT_0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_2: PBPK_model_human_Ab|CDA1|Compound type 2(0)

Parameter: PBPK_model_human_Ab|CDA1|Is small molecule
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|CDA1|Is strong base
	IsFixed: False
	Value: 0
	Formula: (CT_0=1 AND pKa_0>=7) OR (CT_1=1 AND pKa_1>=7) OR (CT_2=1 AND pKa_2>=7)
		CT_0: PBPK_model_human_Ab|CDA1|Compound type 0(0)
		CT_1: PBPK_model_human_Ab|CDA1|Compound type 1(0)
		CT_2: PBPK_model_human_Ab|CDA1|Compound type 2(0)
		pKa_0: PBPK_model_human_Ab|CDA1|pKa value 0(0)
		pKa_1: PBPK_model_human_Ab|CDA1|pKa value 1(0)
		pKa_2: PBPK_model_human_Ab|CDA1|pKa value 2(0)

Parameter: PBPK_model_human_Ab|CDA1|Is triprotic acid
	IsFixed: False
	Value: 0
	Formula: pKa_Acids_Count=3 & pKa_Bases_Count = 0 ? 1 : 0
		pKa_Acids_Count: PBPK_model_human_Ab|CDA1|pKa_Acids_Count(0)
		pKa_Bases_Count: PBPK_model_human_Ab|CDA1|pKa_Bases_Count(0)

Parameter: PBPK_model_human_Ab|CDA1|Compound type 2
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|CDA1|Is diprotic acid
	IsFixed: False
	Value: 0
	Formula: pKa_Acids_Count=2 & pKa_Bases_Count = 0 ? 1 : 0
		pKa_Acids_Count: PBPK_model_human_Ab|CDA1|pKa_Acids_Count(0)
		pKa_Bases_Count: PBPK_model_human_Ab|CDA1|pKa_Bases_Count(0)

Parameter: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_K4
	IsFixed: False
	Value: 0
	Formula: F1*F2*(1-F3)
		F1: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F1(1)
		F2: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F2(1)
		F3: PBPK_model_human_Ab|CDA1|pKa_pH_WS_sol_F3(1)

Parameter: PBPK_model_human_Ab|CDA1|Lipophilicity
	IsFixed: False
	Value: -5 [Log Units]
	Formula: -5

Parameter: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma, reference value)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|CDA1|Solubility at reference pH
	IsFixed: False
	Value: 0.000999 [kg/l]
	Formula: 0.000999

Parameter: PBPK_model_human_Ab|CDA1|Reference pH
	IsFixed: False
	Value: 7
	Formula: 7

Parameter: PBPK_model_human_Ab|CDA1|Solubility gain per charge
	IsFixed: False
	Value: 1000
	Formula: 1000

Parameter: PBPK_model_human_Ab|CDA1|Permeability
	IsFixed: False
	Value: 0 [dm/min]
	Formula: IsSmallMolecule ? (MWEff *1E9 / 336) ^ (-6) * 10^LogMA / 5 * 1E-4 *1E-1: 0
		MWEff: PBPK_model_human_Ab|CDA1|Effective molecular weight(0.00015 [kg/µmol])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])

Parameter: PBPK_model_human_Ab|CDA1|Specific intestinal permeability (transcellular)
	IsFixed: False
	Value: 0 [dm/min]
	Formula: IsSmallMolecule ? 266 * (MWEff * 1E9) ^ ( - 4.5) * 10^LogMA * 60 *1E-1 : 0
		MWEff: PBPK_model_human_Ab|CDA1|Effective molecular weight(0.00015 [kg/µmol])
		IsSmallMolecule: PBPK_model_human_Ab|CDA1|Is small molecule(0)
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])

Parameter: PBPK_model_human_Ab|CDA1|Partition coefficient (water/protein)
	IsFixed: False
	Value: 0.162520284911717
	Formula: (0.81 + 0.11 * 10^LogMA) / 24.92 * 5.0
		LogMA: PBPK_model_human_Ab|CDA1|Lipophilicity(-5 [Log Units])

Parameter: PBPK_model_human_Ab|CDA1|Treat precipitated drug as
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|CDA1|Aqueous diffusion coefficient
	IsFixed: False
	Value: 1.90322787174852E-07 [dm²/min]
	Formula: 60 * 10^(-4.113-0.4609*Log10(MW * 1E9)) *1E-2
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])

Parameter: PBPK_model_human_Ab|CDA1|Density (drug)
	IsFixed: False
	Value: 1 [kg/dm³]
	Formula: 1

Parameter: PBPK_model_human_Ab|CDA1|Immediately dissolve particles smaller than
	IsFixed: False
	Value: 1E-07 [dm]
	Formula: 1E-07

Parameter: PBPK_model_human_Ab|CDA1|Radius (solute)
	IsFixed: True
	Value: 5.34E-08 [dm]
	Formula: 0,0333 * (MW * 1E9) ^ 0,4226 * 1E-8
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])

Parameter: PBPK_model_human_Ab|CDA1|Kd (FcRn) in endosomal space
	IsFixed: False
	Value: 0.63 [µmol/l]
	Formula: 0.63

Parameter: PBPK_model_human_Ab|CDA1|Kd (FcRn) in plasma/interstitial
	IsFixed: False
	Value: 999999 [µmol/l]
	Formula: 999999

Parameter: PBPK_model_human_Ab|CDA1|kass (FcRn)
	IsFixed: False
	Value: 0.87 [l/µmol/min]
	Formula: 0.87

Parameter: PBPK_model_human_Ab|CDA1|Use pH- and pKa-dependent penalty factor for charged molecule fraction
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|CDA1|Parameter m for correlation of intestinal permeability (transcellular)
	IsFixed: False
	Value: 1
	Formula: 1

Parameter: PBPK_model_human_Ab|CDA1|Parameter b for correlation of intestinal permeability (transcellular)
	IsFixed: False
	Value: 0
	Formula: 0

Parameter: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|Application rate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|Volume
	IsFixed: False
	Value: 1 [l]
	Formula: 1

Parameter: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|ProtocolSchemaItem|Start time
	IsFixed: False
	Value: 0 [min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|ProtocolSchemaItem|Dose
	IsFixed: False
	Value: 8.76000001235081E-05 [kg]
	Formula: DosePerBodyWeight * BW
		DosePerBodyWeight: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|ProtocolSchemaItem|DosePerBodyWeight(1.2E-06 [kg/kg])
		BW: PBPK_model_human_Ab|Organism|Weight(73.0000001029235 [kg])

Parameter: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|ProtocolSchemaItem|DrugMass
	IsFixed: False
	Value: 0.584000000823388 [µmol]
	Formula: Dose / MW
		Dose: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|ProtocolSchemaItem|Dose(8.76000001235081E-05 [kg])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
	Tags: CDA1
Parameter: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|ProtocolSchemaItem|DosePerBodyWeight
	IsFixed: False
	Value: 1.2E-06 [kg/kg]
	Formula: 1.2E-06

Parameter: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|ProtocolSchemaItem|Infusion time
	IsFixed: False
	Value: 30 [min]
	Formula: 30

Parameter: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|CDA1|Concentration
	IsFixed: False
	Value: 0.584000000823388 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|CDA1(0.584000000823388 [µmol])
		V: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|Volume(1 [l])

Parameter: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|Application rate
	IsFixed: False
	Value: 0 [µmol/min]
	Formula: 0

Parameter: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|Volume
	IsFixed: False
	Value: 1 [l]
	Formula: 1

Parameter: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|ProtocolSchemaItem|Start time
	IsFixed: False
	Value: 30 [min]
	Formula: 30

Parameter: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|ProtocolSchemaItem|Dose
	IsFixed: False
	Value: 0.00137240000193496 [kg]
	Formula: DosePerBodyWeight * BW
		DosePerBodyWeight: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|ProtocolSchemaItem|DosePerBodyWeight(1.88E-05 [kg/kg])
		BW: PBPK_model_human_Ab|Organism|Weight(73.0000001029235 [kg])

Parameter: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|ProtocolSchemaItem|DrugMass
	IsFixed: False
	Value: 9.14933334623307 [µmol]
	Formula: Dose / MW
		Dose: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|ProtocolSchemaItem|Dose(0.00137240000193496 [kg])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
	Tags: CDA1
Parameter: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|ProtocolSchemaItem|DosePerBodyWeight
	IsFixed: False
	Value: 1.88E-05 [kg/kg]
	Formula: 1.88E-05

Parameter: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|ProtocolSchemaItem|Infusion time
	IsFixed: False
	Value: 150 [min]
	Formula: 150

Parameter: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|CDA1|Concentration
	IsFixed: False
	Value: 9.14933334623307 [µmol/l]
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|CDA1(9.14933334623307 [µmol])
		V: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|Volume(1 [l])

--------------- OBSERVER (Non zero only) ----------
Observer: Blood Cells
	Path: PBPK_model_human_Ab|Organism|PeripheralVenousBlood|CDA1|Blood Cells
	Formula: fQ_art*C_bc_art+fQ_bon*C_bc_bon+fQ_fat*C_bc_fat+fQ_mus*C_bc_mus+fQ_skn*C_bc_skn
		C_bc_art: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_bc_bon: PBPK_model_human_Ab|Organism|Bone|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_bc_fat: PBPK_model_human_Ab|Organism|Fat|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_bc_mus: PBPK_model_human_Ab|Organism|Muscle|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_bc_skn: PBPK_model_human_Ab|Organism|Skin|BloodCells|CDA1|Concentration(0 [µmol/l])
		fQ_art: PBPK_model_human_Ab|Organism|ArterialBlood|Peripheral blood flow fraction(0)
		fQ_bon: PBPK_model_human_Ab|Organism|Bone|Peripheral blood flow fraction(0)
		fQ_fat: PBPK_model_human_Ab|Organism|Fat|Peripheral blood flow fraction(0)
		fQ_mus: PBPK_model_human_Ab|Organism|Muscle|Peripheral blood flow fraction(0.287)
		fQ_skn: PBPK_model_human_Ab|Organism|Skin|Peripheral blood flow fraction(0.713)

Observer: Plasma (Peripheral Venous Blood)
	Path: PBPK_model_human_Ab|Organism|PeripheralVenousBlood|CDA1|Plasma (Peripheral Venous Blood)
	Formula: fQ_art*C_pls_art+fQ_bon*C_pls_bon+fQ_fat*C_pls_fat+fQ_mus*C_pls_mus+fQ_skn*C_pls_skn
		C_pls_art: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		C_pls_bon: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1|Concentration(0 [µmol/l])
		C_pls_fat: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1|Concentration(0 [µmol/l])
		C_pls_mus: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1|Concentration(0 [µmol/l])
		C_pls_skn: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1|Concentration(0 [µmol/l])
		fQ_art: PBPK_model_human_Ab|Organism|ArterialBlood|Peripheral blood flow fraction(0)
		fQ_bon: PBPK_model_human_Ab|Organism|Bone|Peripheral blood flow fraction(0)
		fQ_fat: PBPK_model_human_Ab|Organism|Fat|Peripheral blood flow fraction(0)
		fQ_mus: PBPK_model_human_Ab|Organism|Muscle|Peripheral blood flow fraction(0.287)
		fQ_skn: PBPK_model_human_Ab|Organism|Skin|Peripheral blood flow fraction(0.713)

Observer: Plasma Unbound (Peripheral Venous Blood)
	Path: PBPK_model_human_Ab|Organism|PeripheralVenousBlood|CDA1|Plasma Unbound (Peripheral Venous Blood)
	Formula: (fQ_art*C_pls_art+fQ_bon*C_pls_bon+fQ_fat*C_pls_fat+fQ_mus*C_pls_mus+fQ_skn*C_pls_skn)*fu
		C_pls_art: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		C_pls_bon: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1|Concentration(0 [µmol/l])
		C_pls_fat: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1|Concentration(0 [µmol/l])
		C_pls_mus: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1|Concentration(0 [µmol/l])
		C_pls_skn: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)
		fQ_art: PBPK_model_human_Ab|Organism|ArterialBlood|Peripheral blood flow fraction(0)
		fQ_bon: PBPK_model_human_Ab|Organism|Bone|Peripheral blood flow fraction(0)
		fQ_fat: PBPK_model_human_Ab|Organism|Fat|Peripheral blood flow fraction(0)
		fQ_mus: PBPK_model_human_Ab|Organism|Muscle|Peripheral blood flow fraction(0.287)
		fQ_skn: PBPK_model_human_Ab|Organism|Skin|Peripheral blood flow fraction(0.713)

Observer: Whole Blood (Peripheral Venous Blood)
	Path: PBPK_model_human_Ab|Organism|PeripheralVenousBlood|CDA1|Whole Blood (Peripheral Venous Blood)
	Formula: (1-HCT)*(fQ_art*C_pls_art+fQ_bon*C_pls_bon+fQ_fat*C_pls_fat+fQ_mus*C_pls_mus+fQ_skn*C_pls_skn) + HCT*(fQ_art*C_bc_art+fQ_bon*C_bc_bon+fQ_fat*C_bc_fat+fQ_mus*C_bc_mus+fQ_skn*C_bc_skn)
		C_bc_art: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_bc_bon: PBPK_model_human_Ab|Organism|Bone|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_bc_fat: PBPK_model_human_Ab|Organism|Fat|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_bc_mus: PBPK_model_human_Ab|Organism|Muscle|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_bc_skn: PBPK_model_human_Ab|Organism|Skin|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls_art: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		C_pls_bon: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1|Concentration(0 [µmol/l])
		C_pls_fat: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1|Concentration(0 [µmol/l])
		C_pls_mus: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1|Concentration(0 [µmol/l])
		C_pls_skn: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1|Concentration(0 [µmol/l])
		fQ_art: PBPK_model_human_Ab|Organism|ArterialBlood|Peripheral blood flow fraction(0)
		fQ_bon: PBPK_model_human_Ab|Organism|Bone|Peripheral blood flow fraction(0)
		fQ_fat: PBPK_model_human_Ab|Organism|Fat|Peripheral blood flow fraction(0)
		fQ_mus: PBPK_model_human_Ab|Organism|Muscle|Peripheral blood flow fraction(0.287)
		fQ_skn: PBPK_model_human_Ab|Organism|Skin|Peripheral blood flow fraction(0.713)
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|Volume(0.510913940078214 [l])

Observer: Plasma Unbound
	Path: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1|Plasma Unbound
	Formula: C_pls*fu
		C_pls: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|Volume(0.453074626107095 [l])

Observer: Whole Blood
	Path: PBPK_model_human_Ab|Organism|VenousBlood|CDA1|Whole Blood
	Formula: (1 - HCT) * C_pls+HCT * C_bc
		C_bc: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|VenousBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|Volume(0.222134387972578 [l])

Observer: Plasma Unbound
	Path: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Plasma Unbound
	Formula: C_pls*fu
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|Volume(0.196987098768135 [l])

Observer: Whole Blood
	Path: PBPK_model_human_Ab|Organism|ArterialBlood|CDA1|Whole Blood
	Formula: (1 - HCT) * C_pls+HCT * C_bc
		C_bc: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Bone|Plasma|Volume(0.21297361860168 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Bone|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Bone|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Bone|BloodCells|Volume(0.188863397627905 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Bone|Interstitial|Volume(1.18187357714584 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Bone|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Bone|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Bone|Intracellular|Volume(10.2350251780829 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Bone|Endosome|Volume(0.00229047099250863 [l])

Observer: Interstitial Unbound
	Path: PBPK_model_human_Ab|Organism|Bone|CDA1|Interstitial Unbound
	Formula: C_int * K_water_int
		C_int: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound
	Path: PBPK_model_human_Ab|Organism|Bone|CDA1|Intracellular Unbound
	Formula: C_cell * K_water_cell
		C_cell: PBPK_model_human_Ab|Organism|Bone|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell: PBPK_model_human_Ab|Organism|Bone|Intracellular|CDA1|Partition coefficient (water/container)(1.96634360525929)

Observer: Tissue
	Path: PBPK_model_human_Ab|Organism|Bone|CDA1|Tissue
	Formula: (V_int*C_int+V_cell*C_cell+V_end*C_end)/(V_int+V_cell+V_end)
		V_end: PBPK_model_human_Ab|Organism|Bone|Endosome|Volume(0.00229047099250863 [l])
		V_int: PBPK_model_human_Ab|Organism|Bone|Interstitial|Volume(1.18187357714584 [l])
		V_cell: PBPK_model_human_Ab|Organism|Bone|Intracellular|Volume(10.2350251780829 [l])
		C_cell: PBPK_model_human_Ab|Organism|Bone|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1|Concentration(0 [µmol/l])

Observer: Whole Organ
	Path: PBPK_model_human_Ab|Organism|Bone|CDA1|Whole Organ
	Formula: (fBloodForSampling*(V_pls*C_pls + V_bc*C_bc) + V_end*C_end + V_int*C_int + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Bone|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Bone|BloodCells|Volume(0.188863397627905 [l])
		V_end: PBPK_model_human_Ab|Organism|Bone|Endosome|Volume(0.00229047099250863 [l])
		V_int: PBPK_model_human_Ab|Organism|Bone|Interstitial|Volume(1.18187357714584 [l])
		V_cell: PBPK_model_human_Ab|Organism|Bone|Intracellular|Volume(10.2350251780829 [l])
		V_pls: PBPK_model_human_Ab|Organism|Bone|Plasma|Volume(0.21297361860168 [l])
		C_bc: PBPK_model_human_Ab|Organism|Bone|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Bone|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Whole Organ incl. FcRn_Complex-CDA1
	Path: PBPK_model_human_Ab|Organism|Bone|CDA1|Whole Organ incl. FcRn_Complex-CDA1
	Formula: (fBloodForSampling*(V_pls*(C_pls+C_pls_Complex) + V_bc*C_bc) + V_end*(C_end+C_end_Complex) + V_int*(C_int+C_int_Complex) + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Bone|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Bone|BloodCells|Volume(0.188863397627905 [l])
		V_end: PBPK_model_human_Ab|Organism|Bone|Endosome|Volume(0.00229047099250863 [l])
		V_int: PBPK_model_human_Ab|Organism|Bone|Interstitial|Volume(1.18187357714584 [l])
		V_cell: PBPK_model_human_Ab|Organism|Bone|Intracellular|Volume(10.2350251780829 [l])
		V_pls: PBPK_model_human_Ab|Organism|Bone|Plasma|Volume(0.21297361860168 [l])
		C_end_Complex: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_int_Complex: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_pls_Complex: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_bc: PBPK_model_human_Ab|Organism|Bone|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Bone|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Bone|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Bone|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Bone|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Fraction excreted to bile
	Path: PBPK_model_human_Ab|Organism|Gallbladder|CDA1|Fraction excreted to bile
	Formula: TotalDrugMass>0 ? M/TotalDrugMass : 0
		M: PBPK_model_human_Ab|Organism|Gallbladder|CDA1(0 [µmol])
		TotalDrugMass: PBPK_model_human_Ab|CDA1|Total drug mass(9.73333334705646 [µmol])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Brain|Plasma|Volume(0.0311943841534115 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Brain|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Brain|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Brain|BloodCells|Volume(0.0276629444379309 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Brain|Interstitial|Volume(0.00603664908629153 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Brain|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Brain|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Brain|Intracellular|Volume(1.44426829389525 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Brain|Endosome|Volume(0.000335486772970652 [l])

Observer: Interstitial Unbound
	Path: PBPK_model_human_Ab|Organism|Brain|CDA1|Interstitial Unbound
	Formula: C_int * K_water_int
		C_int: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound
	Path: PBPK_model_human_Ab|Organism|Brain|CDA1|Intracellular Unbound
	Formula: C_cell * K_water_cell
		C_cell: PBPK_model_human_Ab|Organism|Brain|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell: PBPK_model_human_Ab|Organism|Brain|Intracellular|CDA1|Partition coefficient (water/container)(1.2177816930632)

Observer: Tissue
	Path: PBPK_model_human_Ab|Organism|Brain|CDA1|Tissue
	Formula: (V_int*C_int+V_cell*C_cell+V_end*C_end)/(V_int+V_cell+V_end)
		V_end: PBPK_model_human_Ab|Organism|Brain|Endosome|Volume(0.000335486772970652 [l])
		V_int: PBPK_model_human_Ab|Organism|Brain|Interstitial|Volume(0.00603664908629153 [l])
		V_cell: PBPK_model_human_Ab|Organism|Brain|Intracellular|Volume(1.44426829389525 [l])
		C_cell: PBPK_model_human_Ab|Organism|Brain|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1|Concentration(0 [µmol/l])

Observer: Whole Organ
	Path: PBPK_model_human_Ab|Organism|Brain|CDA1|Whole Organ
	Formula: (fBloodForSampling*(V_pls*C_pls + V_bc*C_bc) + V_end*C_end + V_int*C_int + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Brain|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Brain|BloodCells|Volume(0.0276629444379309 [l])
		V_end: PBPK_model_human_Ab|Organism|Brain|Endosome|Volume(0.000335486772970652 [l])
		V_int: PBPK_model_human_Ab|Organism|Brain|Interstitial|Volume(0.00603664908629153 [l])
		V_cell: PBPK_model_human_Ab|Organism|Brain|Intracellular|Volume(1.44426829389525 [l])
		V_pls: PBPK_model_human_Ab|Organism|Brain|Plasma|Volume(0.0311943841534115 [l])
		C_bc: PBPK_model_human_Ab|Organism|Brain|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Brain|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Whole Organ incl. FcRn_Complex-CDA1
	Path: PBPK_model_human_Ab|Organism|Brain|CDA1|Whole Organ incl. FcRn_Complex-CDA1
	Formula: (fBloodForSampling*(V_pls*(C_pls+C_pls_Complex) + V_bc*C_bc) + V_end*(C_end+C_end_Complex) + V_int*(C_int+C_int_Complex) + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Brain|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Brain|BloodCells|Volume(0.0276629444379309 [l])
		V_end: PBPK_model_human_Ab|Organism|Brain|Endosome|Volume(0.000335486772970652 [l])
		V_int: PBPK_model_human_Ab|Organism|Brain|Interstitial|Volume(0.00603664908629153 [l])
		V_cell: PBPK_model_human_Ab|Organism|Brain|Intracellular|Volume(1.44426829389525 [l])
		V_pls: PBPK_model_human_Ab|Organism|Brain|Plasma|Volume(0.0311943841534115 [l])
		C_end_Complex: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_int_Complex: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_pls_Complex: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_bc: PBPK_model_human_Ab|Organism|Brain|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Brain|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Brain|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Brain|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Brain|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Fat|Plasma|Volume(0.139839566189771 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Fat|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Fat|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Fat|BloodCells|Volume(0.124008671904136 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Fat|Interstitial|Volume(2.34531767194584 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Fat|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Fat|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Fat|Intracellular|Volume(12.0490695396217 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Fat|Endosome|Volume(0.00150393495713527 [l])

Observer: Interstitial Unbound
	Path: PBPK_model_human_Ab|Organism|Fat|CDA1|Interstitial Unbound
	Formula: C_int * K_water_int
		C_int: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound
	Path: PBPK_model_human_Ab|Organism|Fat|CDA1|Intracellular Unbound
	Formula: C_cell * K_water_cell
		C_cell: PBPK_model_human_Ab|Organism|Fat|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell: PBPK_model_human_Ab|Organism|Fat|Intracellular|CDA1|Partition coefficient (water/container)(6.3237501733623)

Observer: Tissue
	Path: PBPK_model_human_Ab|Organism|Fat|CDA1|Tissue
	Formula: (V_int*C_int+V_cell*C_cell+V_end*C_end)/(V_int+V_cell+V_end)
		V_end: PBPK_model_human_Ab|Organism|Fat|Endosome|Volume(0.00150393495713527 [l])
		V_int: PBPK_model_human_Ab|Organism|Fat|Interstitial|Volume(2.34531767194584 [l])
		V_cell: PBPK_model_human_Ab|Organism|Fat|Intracellular|Volume(12.0490695396217 [l])
		C_cell: PBPK_model_human_Ab|Organism|Fat|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1|Concentration(0 [µmol/l])

Observer: Whole Organ
	Path: PBPK_model_human_Ab|Organism|Fat|CDA1|Whole Organ
	Formula: (fBloodForSampling*(V_pls*C_pls + V_bc*C_bc) + V_end*C_end + V_int*C_int + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Fat|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Fat|BloodCells|Volume(0.124008671904136 [l])
		V_end: PBPK_model_human_Ab|Organism|Fat|Endosome|Volume(0.00150393495713527 [l])
		V_int: PBPK_model_human_Ab|Organism|Fat|Interstitial|Volume(2.34531767194584 [l])
		V_cell: PBPK_model_human_Ab|Organism|Fat|Intracellular|Volume(12.0490695396217 [l])
		V_pls: PBPK_model_human_Ab|Organism|Fat|Plasma|Volume(0.139839566189771 [l])
		C_bc: PBPK_model_human_Ab|Organism|Fat|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Fat|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Whole Organ incl. FcRn_Complex-CDA1
	Path: PBPK_model_human_Ab|Organism|Fat|CDA1|Whole Organ incl. FcRn_Complex-CDA1
	Formula: (fBloodForSampling*(V_pls*(C_pls+C_pls_Complex) + V_bc*C_bc) + V_end*(C_end+C_end_Complex) + V_int*(C_int+C_int_Complex) + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Fat|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Fat|BloodCells|Volume(0.124008671904136 [l])
		V_end: PBPK_model_human_Ab|Organism|Fat|Endosome|Volume(0.00150393495713527 [l])
		V_int: PBPK_model_human_Ab|Organism|Fat|Interstitial|Volume(2.34531767194584 [l])
		V_cell: PBPK_model_human_Ab|Organism|Fat|Intracellular|Volume(12.0490695396217 [l])
		V_pls: PBPK_model_human_Ab|Organism|Fat|Plasma|Volume(0.139839566189771 [l])
		C_end_Complex: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_int_Complex: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_pls_Complex: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_bc: PBPK_model_human_Ab|Organism|Fat|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Fat|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Fat|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Fat|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Fat|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Gonads|Plasma|Volume(0.00117384300516067 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Gonads|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Gonads|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Gonads|BloodCells|Volume(0.00104095511778399 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Gonads|Interstitial|Volume(0.00277856491787602 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Gonads|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Gonads|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Gonads|Intracellular|Volume(0.0352756937399912 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Gonads|Endosome|Volume(1.26243493007845E-05 [l])

Observer: Interstitial Unbound
	Path: PBPK_model_human_Ab|Organism|Gonads|CDA1|Interstitial Unbound
	Formula: C_int * K_water_int
		C_int: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound
	Path: PBPK_model_human_Ab|Organism|Gonads|CDA1|Intracellular Unbound
	Formula: C_cell * K_water_cell
		C_cell: PBPK_model_human_Ab|Organism|Gonads|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell: PBPK_model_human_Ab|Organism|Gonads|Intracellular|CDA1|Partition coefficient (water/container)(1.22025216765946)

Observer: Tissue
	Path: PBPK_model_human_Ab|Organism|Gonads|CDA1|Tissue
	Formula: (V_int*C_int+V_cell*C_cell+V_end*C_end)/(V_int+V_cell+V_end)
		V_end: PBPK_model_human_Ab|Organism|Gonads|Endosome|Volume(1.26243493007845E-05 [l])
		V_int: PBPK_model_human_Ab|Organism|Gonads|Interstitial|Volume(0.00277856491787602 [l])
		V_cell: PBPK_model_human_Ab|Organism|Gonads|Intracellular|Volume(0.0352756937399912 [l])
		C_cell: PBPK_model_human_Ab|Organism|Gonads|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1|Concentration(0 [µmol/l])

Observer: Whole Organ
	Path: PBPK_model_human_Ab|Organism|Gonads|CDA1|Whole Organ
	Formula: (fBloodForSampling*(V_pls*C_pls + V_bc*C_bc) + V_end*C_end + V_int*C_int + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Gonads|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Gonads|BloodCells|Volume(0.00104095511778399 [l])
		V_end: PBPK_model_human_Ab|Organism|Gonads|Endosome|Volume(1.26243493007845E-05 [l])
		V_int: PBPK_model_human_Ab|Organism|Gonads|Interstitial|Volume(0.00277856491787602 [l])
		V_cell: PBPK_model_human_Ab|Organism|Gonads|Intracellular|Volume(0.0352756937399912 [l])
		V_pls: PBPK_model_human_Ab|Organism|Gonads|Plasma|Volume(0.00117384300516067 [l])
		C_bc: PBPK_model_human_Ab|Organism|Gonads|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Gonads|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Whole Organ incl. FcRn_Complex-CDA1
	Path: PBPK_model_human_Ab|Organism|Gonads|CDA1|Whole Organ incl. FcRn_Complex-CDA1
	Formula: (fBloodForSampling*(V_pls*(C_pls+C_pls_Complex) + V_bc*C_bc) + V_end*(C_end+C_end_Complex) + V_int*(C_int+C_int_Complex) + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Gonads|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Gonads|BloodCells|Volume(0.00104095511778399 [l])
		V_end: PBPK_model_human_Ab|Organism|Gonads|Endosome|Volume(1.26243493007845E-05 [l])
		V_int: PBPK_model_human_Ab|Organism|Gonads|Interstitial|Volume(0.00277856491787602 [l])
		V_cell: PBPK_model_human_Ab|Organism|Gonads|Intracellular|Volume(0.0352756937399912 [l])
		V_pls: PBPK_model_human_Ab|Organism|Gonads|Plasma|Volume(0.00117384300516067 [l])
		C_end_Complex: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_int_Complex: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_pls_Complex: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_bc: PBPK_model_human_Ab|Organism|Gonads|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Gonads|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Gonads|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Gonads|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Gonads|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Heart|Plasma|Volume(0.0309860416860081 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Heart|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Heart|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Heart|BloodCells|Volume(0.0274781879102336 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Heart|Interstitial|Volume(0.0417601639973155 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Heart|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Heart|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Heart|Intracellular|Volume(0.317377246379598 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Heart|Endosome|Volume(0.000333246108698578 [l])

Observer: Interstitial Unbound
	Path: PBPK_model_human_Ab|Organism|Heart|CDA1|Interstitial Unbound
	Formula: C_int * K_water_int
		C_int: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound
	Path: PBPK_model_human_Ab|Organism|Heart|CDA1|Intracellular Unbound
	Formula: C_cell * K_water_cell
		C_cell: PBPK_model_human_Ab|Organism|Heart|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell: PBPK_model_human_Ab|Organism|Heart|Intracellular|CDA1|Partition coefficient (water/container)(1.31873161968723)

Observer: Tissue
	Path: PBPK_model_human_Ab|Organism|Heart|CDA1|Tissue
	Formula: (V_int*C_int+V_cell*C_cell+V_end*C_end)/(V_int+V_cell+V_end)
		V_end: PBPK_model_human_Ab|Organism|Heart|Endosome|Volume(0.000333246108698578 [l])
		V_int: PBPK_model_human_Ab|Organism|Heart|Interstitial|Volume(0.0417601639973155 [l])
		V_cell: PBPK_model_human_Ab|Organism|Heart|Intracellular|Volume(0.317377246379598 [l])
		C_cell: PBPK_model_human_Ab|Organism|Heart|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1|Concentration(0 [µmol/l])

Observer: Whole Organ
	Path: PBPK_model_human_Ab|Organism|Heart|CDA1|Whole Organ
	Formula: (fBloodForSampling*(V_pls*C_pls + V_bc*C_bc) + V_end*C_end + V_int*C_int + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Heart|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Heart|BloodCells|Volume(0.0274781879102336 [l])
		V_end: PBPK_model_human_Ab|Organism|Heart|Endosome|Volume(0.000333246108698578 [l])
		V_int: PBPK_model_human_Ab|Organism|Heart|Interstitial|Volume(0.0417601639973155 [l])
		V_cell: PBPK_model_human_Ab|Organism|Heart|Intracellular|Volume(0.317377246379598 [l])
		V_pls: PBPK_model_human_Ab|Organism|Heart|Plasma|Volume(0.0309860416860081 [l])
		C_bc: PBPK_model_human_Ab|Organism|Heart|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Heart|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Whole Organ incl. FcRn_Complex-CDA1
	Path: PBPK_model_human_Ab|Organism|Heart|CDA1|Whole Organ incl. FcRn_Complex-CDA1
	Formula: (fBloodForSampling*(V_pls*(C_pls+C_pls_Complex) + V_bc*C_bc) + V_end*(C_end+C_end_Complex) + V_int*(C_int+C_int_Complex) + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Heart|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Heart|BloodCells|Volume(0.0274781879102336 [l])
		V_end: PBPK_model_human_Ab|Organism|Heart|Endosome|Volume(0.000333246108698578 [l])
		V_int: PBPK_model_human_Ab|Organism|Heart|Interstitial|Volume(0.0417601639973155 [l])
		V_cell: PBPK_model_human_Ab|Organism|Heart|Intracellular|Volume(0.317377246379598 [l])
		V_pls: PBPK_model_human_Ab|Organism|Heart|Plasma|Volume(0.0309860416860081 [l])
		C_end_Complex: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_int_Complex: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_pls_Complex: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_bc: PBPK_model_human_Ab|Organism|Heart|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Heart|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Heart|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Heart|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Heart|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Kidney|Plasma|Volume(0.0534462425234655 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Kidney|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Kidney|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Kidney|BloodCells|Volume(0.0473957245019411 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Kidney|Interstitial|Volume(0.0876886669786144 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Kidney|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Kidney|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Kidney|Intracellular|Volume(0.249912700889051 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Kidney|Endosome|Volume(0.000574799212044817 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Kidney|Urine|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Kidney|Urine|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Kidney|Urine|Volume(1 [l])

Observer: Fraction excreted to urine
	Path: PBPK_model_human_Ab|Organism|Kidney|Urine|CDA1|Fraction excreted to urine
	Formula: TotalDrugMass>0 ? M/TotalDrugMass : 0
		M: PBPK_model_human_Ab|Organism|Kidney|Urine|CDA1(0 [µmol])
		TotalDrugMass: PBPK_model_human_Ab|CDA1|Total drug mass(9.73333334705646 [µmol])

Observer: Interstitial Unbound
	Path: PBPK_model_human_Ab|Organism|Kidney|CDA1|Interstitial Unbound
	Formula: C_int * K_water_int
		C_int: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound
	Path: PBPK_model_human_Ab|Organism|Kidney|CDA1|Intracellular Unbound
	Formula: C_cell * K_water_cell
		C_cell: PBPK_model_human_Ab|Organism|Kidney|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell: PBPK_model_human_Ab|Organism|Kidney|Intracellular|CDA1|Partition coefficient (water/container)(1.24720705329081)

Observer: Tissue
	Path: PBPK_model_human_Ab|Organism|Kidney|CDA1|Tissue
	Formula: (V_int*C_int+V_cell*C_cell+V_end*C_end)/(V_int+V_cell+V_end)
		V_end: PBPK_model_human_Ab|Organism|Kidney|Endosome|Volume(0.000574799212044817 [l])
		V_int: PBPK_model_human_Ab|Organism|Kidney|Interstitial|Volume(0.0876886669786144 [l])
		V_cell: PBPK_model_human_Ab|Organism|Kidney|Intracellular|Volume(0.249912700889051 [l])
		C_cell: PBPK_model_human_Ab|Organism|Kidney|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1|Concentration(0 [µmol/l])

Observer: Whole Organ
	Path: PBPK_model_human_Ab|Organism|Kidney|CDA1|Whole Organ
	Formula: (fBloodForSampling*(V_pls*C_pls + V_bc*C_bc) + V_end*C_end + V_int*C_int + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Kidney|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Kidney|BloodCells|Volume(0.0473957245019411 [l])
		V_end: PBPK_model_human_Ab|Organism|Kidney|Endosome|Volume(0.000574799212044817 [l])
		V_int: PBPK_model_human_Ab|Organism|Kidney|Interstitial|Volume(0.0876886669786144 [l])
		V_cell: PBPK_model_human_Ab|Organism|Kidney|Intracellular|Volume(0.249912700889051 [l])
		V_pls: PBPK_model_human_Ab|Organism|Kidney|Plasma|Volume(0.0534462425234655 [l])
		C_bc: PBPK_model_human_Ab|Organism|Kidney|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Kidney|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Whole Organ incl. FcRn_Complex-CDA1
	Path: PBPK_model_human_Ab|Organism|Kidney|CDA1|Whole Organ incl. FcRn_Complex-CDA1
	Formula: (fBloodForSampling*(V_pls*(C_pls+C_pls_Complex) + V_bc*C_bc) + V_end*(C_end+C_end_Complex) + V_int*(C_int+C_int_Complex) + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Kidney|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Kidney|BloodCells|Volume(0.0473957245019411 [l])
		V_end: PBPK_model_human_Ab|Organism|Kidney|Endosome|Volume(0.000574799212044817 [l])
		V_int: PBPK_model_human_Ab|Organism|Kidney|Interstitial|Volume(0.0876886669786144 [l])
		V_cell: PBPK_model_human_Ab|Organism|Kidney|Intracellular|Volume(0.249912700889051 [l])
		V_pls: PBPK_model_human_Ab|Organism|Kidney|Plasma|Volume(0.0534462425234655 [l])
		C_end_Complex: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_int_Complex: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_pls_Complex: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_bc: PBPK_model_human_Ab|Organism|Kidney|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Kidney|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Kidney|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Kidney|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Kidney|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in lumen
	Path: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|Concentration in lumen
	Formula: min(Solubility/MW ; M/Liquid)
		M: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1(0 [µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1|Solubility(0.000999 [kg/l])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Stomach|Liquid(0.0473893543830752 [l])

Observer: Concentration in lumen
	Path: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|Concentration in lumen
	Formula: min(Solubility/MW ; M/Liquid)
		M: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1(0 [µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|Solubility(0.000999 [kg/l])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Duodenum|Liquid(0.0120515229563923 [l])

Observer: Fraction of oral drug mass absorbed into mucosa segment
	Path: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|Fraction of oral drug mass absorbed into mucosa segment
	Formula: OralDrugMass>0.0 ?  MassAbsorbed/OralDrugMass : 0
		MassAbsorbed: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1|Oral mass absorbed segment(0 [µmol])
		OralDrugMass: PBPK_model_human_Ab|CDA1|Total oral drug mass(0 [µmol])

Observer: Concentration in lumen
	Path: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|Concentration in lumen
	Formula: min(Solubility/MW ; M/Liquid)
		M: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1(0 [µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|Solubility(0.000999 [kg/l])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|Liquid(0.0257819866318681 [l])

Observer: Fraction of oral drug mass absorbed into mucosa segment
	Path: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|Fraction of oral drug mass absorbed into mucosa segment
	Formula: OralDrugMass>0.0 ?  MassAbsorbed/OralDrugMass : 0
		MassAbsorbed: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1|Oral mass absorbed segment(0 [µmol])
		OralDrugMass: PBPK_model_human_Ab|CDA1|Total oral drug mass(0 [µmol])

Observer: Concentration in lumen
	Path: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|Concentration in lumen
	Formula: min(Solubility/MW ; M/Liquid)
		M: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1(0 [µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|Solubility(0.000999 [kg/l])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|Liquid(0.0225637095370335 [l])

Observer: Fraction of oral drug mass absorbed into mucosa segment
	Path: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|Fraction of oral drug mass absorbed into mucosa segment
	Formula: OralDrugMass>0.0 ?  MassAbsorbed/OralDrugMass : 0
		MassAbsorbed: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1|Oral mass absorbed segment(0 [µmol])
		OralDrugMass: PBPK_model_human_Ab|CDA1|Total oral drug mass(0 [µmol])

Observer: Concentration in lumen
	Path: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|Concentration in lumen
	Formula: min(Solubility/MW ; M/Liquid)
		M: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1(0 [µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|Solubility(0.000999 [kg/l])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|Liquid(0.0270026140608501 [l])

Observer: Fraction of oral drug mass absorbed into mucosa segment
	Path: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|Fraction of oral drug mass absorbed into mucosa segment
	Formula: OralDrugMass>0.0 ?  MassAbsorbed/OralDrugMass : 0
		MassAbsorbed: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1|Oral mass absorbed segment(0 [µmol])
		OralDrugMass: PBPK_model_human_Ab|CDA1|Total oral drug mass(0 [µmol])

Observer: Concentration in lumen
	Path: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|Concentration in lumen
	Formula: min(Solubility/MW ; M/Liquid)
		M: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1(0 [µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|Solubility(0.000999 [kg/l])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|Liquid(0.019348329927017 [l])

Observer: Fraction of oral drug mass absorbed into mucosa segment
	Path: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|Fraction of oral drug mass absorbed into mucosa segment
	Formula: OralDrugMass>0.0 ?  MassAbsorbed/OralDrugMass : 0
		MassAbsorbed: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1|Oral mass absorbed segment(0 [µmol])
		OralDrugMass: PBPK_model_human_Ab|CDA1|Total oral drug mass(0 [µmol])

Observer: Concentration in lumen
	Path: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|Concentration in lumen
	Formula: min(Solubility/MW ; M/Liquid)
		M: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1(0 [µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|Solubility(0.000999 [kg/l])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Caecum|Liquid(0.00130513175379201 [l])

Observer: Fraction of oral drug mass absorbed into mucosa segment
	Path: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|Fraction of oral drug mass absorbed into mucosa segment
	Formula: OralDrugMass>0.0 ?  MassAbsorbed/OralDrugMass : 0
		MassAbsorbed: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1|Oral mass absorbed segment(0 [µmol])
		OralDrugMass: PBPK_model_human_Ab|CDA1|Total oral drug mass(0 [µmol])

Observer: Concentration in lumen
	Path: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|Concentration in lumen
	Formula: min(Solubility/MW ; M/Liquid)
		M: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1(0 [µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|Solubility(0.000999 [kg/l])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|Liquid(0.00364955582686276 [l])

Observer: Fraction of oral drug mass absorbed into mucosa segment
	Path: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|Fraction of oral drug mass absorbed into mucosa segment
	Formula: OralDrugMass>0.0 ?  MassAbsorbed/OralDrugMass : 0
		MassAbsorbed: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1|Oral mass absorbed segment(0 [µmol])
		OralDrugMass: PBPK_model_human_Ab|CDA1|Total oral drug mass(0 [µmol])

Observer: Concentration in lumen
	Path: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|Concentration in lumen
	Formula: min(Solubility/MW ; M/Liquid)
		M: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1(0 [µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|Solubility(0.000999 [kg/l])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|Liquid(0.00454008377608023 [l])

Observer: Fraction of oral drug mass absorbed into mucosa segment
	Path: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|Fraction of oral drug mass absorbed into mucosa segment
	Formula: OralDrugMass>0.0 ?  MassAbsorbed/OralDrugMass : 0
		MassAbsorbed: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1|Oral mass absorbed segment(0 [µmol])
		OralDrugMass: PBPK_model_human_Ab|CDA1|Total oral drug mass(0 [µmol])

Observer: Concentration in lumen
	Path: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|Concentration in lumen
	Formula: min(Solubility/MW ; M/Liquid)
		M: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1(0 [µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|Solubility(0.000999 [kg/l])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|Liquid(0.00156276289737139 [l])

Observer: Fraction of oral drug mass absorbed into mucosa segment
	Path: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|Fraction of oral drug mass absorbed into mucosa segment
	Formula: OralDrugMass>0.0 ?  MassAbsorbed/OralDrugMass : 0
		MassAbsorbed: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1|Oral mass absorbed segment(0 [µmol])
		OralDrugMass: PBPK_model_human_Ab|CDA1|Total oral drug mass(0 [µmol])

Observer: Concentration in lumen
	Path: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|Concentration in lumen
	Formula: min(Solubility/MW ; M/Liquid)
		M: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1(0 [µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|Solubility(0.000999 [kg/l])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|Liquid(0.00193383417529163 [l])

Observer: Fraction of oral drug mass absorbed into mucosa segment
	Path: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|Fraction of oral drug mass absorbed into mucosa segment
	Formula: OralDrugMass>0.0 ?  MassAbsorbed/OralDrugMass : 0
		MassAbsorbed: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1|Oral mass absorbed segment(0 [µmol])
		OralDrugMass: PBPK_model_human_Ab|CDA1|Total oral drug mass(0 [µmol])

Observer: Concentration in lumen
	Path: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|Concentration in lumen
	Formula: min(Solubility/MW ; M/Liquid)
		M: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1(0 [µmol])
		Solubility: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|Solubility(0.000999 [kg/l])
		MW: PBPK_model_human_Ab|CDA1|Molecular weight(0.00015 [kg/µmol])
		Liquid: PBPK_model_human_Ab|Organism|Lumen|Rectum|Liquid(0.000525578833597355 [l])

Observer: Fraction of oral drug mass absorbed into mucosa segment
	Path: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|Fraction of oral drug mass absorbed into mucosa segment
	Formula: OralDrugMass>0.0 ?  MassAbsorbed/OralDrugMass : 0
		MassAbsorbed: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1|Oral mass absorbed segment(0 [µmol])
		OralDrugMass: PBPK_model_human_Ab|CDA1|Total oral drug mass(0 [µmol])

Observer: Concentration in feces
	Path: PBPK_model_human_Ab|Organism|Lumen|Feces|CDA1|Concentration in feces
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lumen|Feces|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lumen|Feces|Volume(1 [l])

Observer: Fraction excreted to feces
	Path: PBPK_model_human_Ab|Organism|Lumen|Feces|CDA1|Fraction excreted to feces
	Formula: TotalDrugMass>0 ? M/TotalDrugMass : 0
		M: PBPK_model_human_Ab|Organism|Lumen|Feces|CDA1(0 [µmol])
		TotalDrugMass: PBPK_model_human_Ab|CDA1|Total drug mass(9.73333334705646 [µmol])

Observer: Fraction dissolved
	Path: PBPK_model_human_Ab|Organism|Lumen|CDA1|Fraction dissolved
	Formula: TotalOralDrugMass > 0 ? (M_sto + M_duo + M_uje + M_lje + M_uil + M_lil + M_cae + M_colasc + M_coltrans + M_coldesc + M_colsigm + M_rect + M_fec + Mabs_Mucosa) / TotalOralDrugMass : 0
		M_cae: PBPK_model_human_Ab|Organism|Lumen|Caecum|CDA1(0 [µmol])
		M_colasc: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens|CDA1(0 [µmol])
		M_coldesc: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens|CDA1(0 [µmol])
		M_colsigm: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid|CDA1(0 [µmol])
		M_coltrans: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum|CDA1(0 [µmol])
		M_duo: PBPK_model_human_Ab|Organism|Lumen|Duodenum|CDA1(0 [µmol])
		M_fec: PBPK_model_human_Ab|Organism|Lumen|Feces|CDA1(0 [µmol])
		M_lil: PBPK_model_human_Ab|Organism|Lumen|LowerIleum|CDA1(0 [µmol])
		M_lje: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum|CDA1(0 [µmol])
		M_rect: PBPK_model_human_Ab|Organism|Lumen|Rectum|CDA1(0 [µmol])
		M_sto: PBPK_model_human_Ab|Organism|Lumen|Stomach|CDA1(0 [µmol])
		M_uil: PBPK_model_human_Ab|Organism|Lumen|UpperIleum|CDA1(0 [µmol])
		M_uje: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum|CDA1(0 [µmol])
		Mabs_Mucosa: PBPK_model_human_Ab|Neighborhoods|Lumen_sto_Lumen_duo|CDA1|Oral mass absorbed(0 [µmol])
		TotalOralDrugMass: PBPK_model_human_Ab|CDA1|Total oral drug mass(0 [µmol])

Observer: Fraction of oral drug mass absorbed into mucosa
	Path: PBPK_model_human_Ab|Organism|Lumen|CDA1|Fraction of oral drug mass absorbed into mucosa
	Formula: OralDrugMass>0.0 ?  MassAbsorbed/OralDrugMass : 0
		MassAbsorbed: PBPK_model_human_Ab|Neighborhoods|Lumen_sto_Lumen_duo|CDA1|Oral mass absorbed(0 [µmol])
		OralDrugMass: PBPK_model_human_Ab|CDA1|Total oral drug mass(0 [µmol])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Stomach|Plasma|Volume(0.00285851376261118 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Stomach|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Stomach|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Stomach|BloodCells|Volume(0.00253490843099482 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Stomach|Interstitial|Volume(0.0168544443550188 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Stomach|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Stomach|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Stomach|Intracellular|Volume(0.146296577001563 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Stomach|Endosome|Volume(3.07425065035542E-05 [l])

Observer: Interstitial Unbound
	Path: PBPK_model_human_Ab|Organism|Stomach|CDA1|Interstitial Unbound
	Formula: C_int * K_water_int
		C_int: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound
	Path: PBPK_model_human_Ab|Organism|Stomach|CDA1|Intracellular Unbound
	Formula: C_cell * K_water_cell
		C_cell: PBPK_model_human_Ab|Organism|Stomach|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell: PBPK_model_human_Ab|Organism|Stomach|Intracellular|CDA1|Partition coefficient (water/container)(1.22908131578533)

Observer: Tissue
	Path: PBPK_model_human_Ab|Organism|Stomach|CDA1|Tissue
	Formula: (V_int*C_int+V_cell*C_cell+V_end*C_end)/(V_int+V_cell+V_end)
		V_end: PBPK_model_human_Ab|Organism|Stomach|Endosome|Volume(3.07425065035542E-05 [l])
		V_int: PBPK_model_human_Ab|Organism|Stomach|Interstitial|Volume(0.0168544443550188 [l])
		V_cell: PBPK_model_human_Ab|Organism|Stomach|Intracellular|Volume(0.146296577001563 [l])
		C_cell: PBPK_model_human_Ab|Organism|Stomach|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1|Concentration(0 [µmol/l])

Observer: Whole Organ
	Path: PBPK_model_human_Ab|Organism|Stomach|CDA1|Whole Organ
	Formula: (fBloodForSampling*(V_pls*C_pls + V_bc*C_bc) + V_end*C_end + V_int*C_int + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Stomach|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Stomach|BloodCells|Volume(0.00253490843099482 [l])
		V_end: PBPK_model_human_Ab|Organism|Stomach|Endosome|Volume(3.07425065035542E-05 [l])
		V_int: PBPK_model_human_Ab|Organism|Stomach|Interstitial|Volume(0.0168544443550188 [l])
		V_cell: PBPK_model_human_Ab|Organism|Stomach|Intracellular|Volume(0.146296577001563 [l])
		V_pls: PBPK_model_human_Ab|Organism|Stomach|Plasma|Volume(0.00285851376261118 [l])
		C_bc: PBPK_model_human_Ab|Organism|Stomach|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Stomach|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Whole Organ incl. FcRn_Complex-CDA1
	Path: PBPK_model_human_Ab|Organism|Stomach|CDA1|Whole Organ incl. FcRn_Complex-CDA1
	Formula: (fBloodForSampling*(V_pls*(C_pls+C_pls_Complex) + V_bc*C_bc) + V_end*(C_end+C_end_Complex) + V_int*(C_int+C_int_Complex) + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Stomach|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Stomach|BloodCells|Volume(0.00253490843099482 [l])
		V_end: PBPK_model_human_Ab|Organism|Stomach|Endosome|Volume(3.07425065035542E-05 [l])
		V_int: PBPK_model_human_Ab|Organism|Stomach|Interstitial|Volume(0.0168544443550188 [l])
		V_cell: PBPK_model_human_Ab|Organism|Stomach|Intracellular|Volume(0.146296577001563 [l])
		V_pls: PBPK_model_human_Ab|Organism|Stomach|Plasma|Volume(0.00285851376261118 [l])
		C_end_Complex: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_int_Complex: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_pls_Complex: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_bc: PBPK_model_human_Ab|Organism|Stomach|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Stomach|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Stomach|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Stomach|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Stomach|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|Volume(0.00739430123772535 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|Volume(0.00655721053156776 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|Volume(0.054643421096398 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|Volume(0.512718057521522 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|Volume(7.95236170849708E-05 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Volume(0.001129096160459 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|Volume(0.00100127395361458 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume(0.00688273421469925 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Volume(0.00737435808717777 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume(1.21431096502194E-05 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Volume(0.00323155107993437 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|Volume(0.00286571510862104 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume(0.0164157166614953 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Volume(0.0243890647542217 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume(3.47544172747659E-05 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Volume(0.00238797348878684 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|Volume(0.00211763686741475 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume(0.0110907331844962 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Volume(0.0190621976608529 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume(2.56819790303491E-05 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Volume(0.00210245491947537 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|Volume(0.00186444115500646 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume(0.00945952140837976 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Volume(0.0170881677054602 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume(2.26113076245465E-05 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Volume(0.00101229310937703 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|Volume(0.000897693889447556 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume(0.00470150645864514 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Volume(0.00808071422579633 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume(1.08869258933002E-05 [l])

Observer: Interstitial Unbound
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|CDA1|Interstitial Unbound
	Formula: C_int * K_water_int
		C_int: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|CDA1|Intracellular Unbound
	Formula: C_cell * K_water_cell
		C_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|CDA1|Partition coefficient (water/container)(1.22908131578533)

Observer: Total Tissue (Small Intestine)
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|CDA1|Total Tissue (Small Intestine)
	Formula: (M_int + M_cell + M_end + M_int_duo + M_cell_duo + M_end_duo + M_int_uje + M_cell_uje + M_end_uje + M_int_lje + M_cell_lje + M_end_lje + M_int_uil + M_cell_uil + M_end_uil + M_int_lil + M_cell_lil + M_end_lil)/(V_int + V_cell + V_end + V_int_duo + V_cell_duo + V_end_duo + V_int_uje + V_cell_uje + V_end_uje + V_int_lje + V_cell_lje + V_end_lje + V_int_uil + V_cell_uil + V_end_uil + V_int_lil + V_cell_lil + V_end_lil)
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|Volume(7.95236170849708E-05 [l])
		V_end_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume(1.21431096502194E-05 [l])
		V_end_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume(1.08869258933002E-05 [l])
		V_end_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume(2.56819790303491E-05 [l])
		V_end_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume(2.26113076245465E-05 [l])
		V_end_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume(3.47544172747659E-05 [l])
		V_int: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|Volume(0.054643421096398 [l])
		V_int_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume(0.00688273421469925 [l])
		V_int_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume(0.00470150645864514 [l])
		V_int_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume(0.0110907331844962 [l])
		V_int_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume(0.00945952140837976 [l])
		V_int_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume(0.0164157166614953 [l])
		V_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|Volume(0.512718057521522 [l])
		V_cell_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Volume(0.00737435808717777 [l])
		V_cell_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Volume(0.00808071422579633 [l])
		V_cell_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Volume(0.0190621976608529 [l])
		V_cell_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Volume(0.0170881677054602 [l])
		V_cell_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Volume(0.0243890647542217 [l])
		M_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|CDA1(0 [µmol])
		M_cell_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CDA1(0 [µmol])
		M_cell_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CDA1(0 [µmol])
		M_cell_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CDA1(0 [µmol])
		M_cell_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CDA1(0 [µmol])
		M_cell_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CDA1(0 [µmol])
		M_end: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1(0 [µmol])
		M_end_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1(0 [µmol])
		M_end_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1(0 [µmol])
		M_end_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1(0 [µmol])
		M_end_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1(0 [µmol])
		M_end_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1(0 [µmol])
		M_int: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1(0 [µmol])
		M_int_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1(0 [µmol])
		M_int_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1(0 [µmol])
		M_int_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1(0 [µmol])
		M_int_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1(0 [µmol])
		M_int_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1(0 [µmol])

Observer: Whole Organ (Small Intestine)
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|CDA1|Whole Organ (Small Intestine)
	Formula: (fBloodForSampling*(M_pls + M_bc + M_pls_duo + M_bc_duo + M_pls_uje + M_bc_uje + M_pls_lje + M_bc_lje + M_pls_uil + M_bc_uil + M_pls_lil + M_bc_lil)+M_int + M_cell + M_end + M_int_duo + M_cell_duo + M_end_duo + M_int_uje + M_cell_uje + M_end_uje + M_int_lje + M_cell_lje + M_end_lje + M_int_uil + M_cell_uil + M_end_uil + M_int_lil + M_cell_lil + M_end_lil)/(fBloodForSampling*(V_pls + V_bc + V_pls_duo + V_bc_duo + V_pls_uje + V_bc_uje + V_pls_lje + V_bc_lje + V_pls_uil + V_bc_uil + V_pls_lil + V_bc_lil) + V_int + V_cell + V_end + V_int_duo + V_cell_duo + V_end_duo + V_int_uje + V_cell_uje + V_end_uje + V_int_lje + V_cell_lje + V_end_lje + V_int_uil + V_cell_uil + V_end_uil + V_int_lil + V_cell_lil + V_end_lil)
		V_bc: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|Volume(0.00655721053156776 [l])
		V_bc_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|Volume(0.00100127395361458 [l])
		V_bc_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|Volume(0.000897693889447556 [l])
		V_bc_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|Volume(0.00211763686741475 [l])
		V_bc_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|Volume(0.00186444115500646 [l])
		V_bc_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|Volume(0.00286571510862104 [l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|Volume(7.95236170849708E-05 [l])
		V_end_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume(1.21431096502194E-05 [l])
		V_end_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume(1.08869258933002E-05 [l])
		V_end_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume(2.56819790303491E-05 [l])
		V_end_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume(2.26113076245465E-05 [l])
		V_end_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume(3.47544172747659E-05 [l])
		V_int: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|Volume(0.054643421096398 [l])
		V_int_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume(0.00688273421469925 [l])
		V_int_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume(0.00470150645864514 [l])
		V_int_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume(0.0110907331844962 [l])
		V_int_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume(0.00945952140837976 [l])
		V_int_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume(0.0164157166614953 [l])
		V_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|Volume(0.512718057521522 [l])
		V_cell_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Volume(0.00737435808717777 [l])
		V_cell_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Volume(0.00808071422579633 [l])
		V_cell_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Volume(0.0190621976608529 [l])
		V_cell_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Volume(0.0170881677054602 [l])
		V_cell_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Volume(0.0243890647542217 [l])
		V_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|Volume(0.00739430123772535 [l])
		V_pls_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Volume(0.001129096160459 [l])
		V_pls_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Volume(0.00101229310937703 [l])
		V_pls_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Volume(0.00238797348878684 [l])
		V_pls_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Volume(0.00210245491947537 [l])
		V_pls_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Volume(0.00323155107993437 [l])
		M_bc: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1(0 [µmol])
		M_bc_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|CDA1(0 [µmol])
		M_bc_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|CDA1(0 [µmol])
		M_bc_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|CDA1(0 [µmol])
		M_bc_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|CDA1(0 [µmol])
		M_bc_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|CDA1(0 [µmol])
		M_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|CDA1(0 [µmol])
		M_cell_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CDA1(0 [µmol])
		M_cell_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CDA1(0 [µmol])
		M_cell_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CDA1(0 [µmol])
		M_cell_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CDA1(0 [µmol])
		M_cell_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CDA1(0 [µmol])
		M_end: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1(0 [µmol])
		M_end_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1(0 [µmol])
		M_end_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1(0 [µmol])
		M_end_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1(0 [µmol])
		M_end_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1(0 [µmol])
		M_end_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1(0 [µmol])
		M_int: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1(0 [µmol])
		M_int_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1(0 [µmol])
		M_int_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1(0 [µmol])
		M_int_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1(0 [µmol])
		M_int_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1(0 [µmol])
		M_int_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1(0 [µmol])
		M_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1(0 [µmol])
		M_pls_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1(0 [µmol])
		M_pls_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1(0 [µmol])
		M_pls_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1(0 [µmol])
		M_pls_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1(0 [µmol])
		M_pls_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1(0 [µmol])
		fBloodForSampling: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction of blood for sampling(1)

Observer: Whole Organ (Small Intestine) incl. FcRn_Complex-CDA1
	Path: PBPK_model_human_Ab|Organism|SmallIntestine|CDA1|Whole Organ (Small Intestine) incl. FcRn_Complex-CDA1
	Formula: (fBloodForSampling*(M_pls+M_pls_Complex + M_bc + M_pls_duo+M_pls_duo_Complex + M_bc_duo + M_pls_uje+M_pls_uje_Complex + M_bc_uje + M_pls_lje+M_pls_lje_Complex + M_bc_lje + M_pls_uil+M_pls_uil_Complex + M_bc_uil + M_pls_lil+M_pls_lil_Complex + M_bc_lil)+M_int+M_int_Complex + M_cell + M_end+M_end_Complex + M_int_duo+M_int_duo_Complex + M_cell_duo + M_end_duo+M_end_duo_Complex + M_int_uje+M_int_uje_Complex + M_cell_uje + M_end_uje+M_end_uje_Complex + M_int_lje+M_int_lje_Complex + M_cell_lje + M_end_lje+M_end_lje_Complex + M_int_uil+M_int_uil_Complex + M_cell_uil + M_end_uil+M_end_uil_Complex + M_int_lil+M_int_lil_Complex + M_cell_lil + M_end_lil+M_end_lil_Complex)/(fBloodForSampling*(V_pls + V_bc + V_pls_duo + V_bc_duo + V_pls_uje + V_bc_uje + V_pls_lje + V_bc_lje + V_pls_uil + V_bc_uil + V_pls_lil + V_bc_lil) + V_int + V_cell + V_end + V_int_duo + V_cell_duo + V_end_duo + V_int_uje + V_cell_uje + V_end_uje + V_int_lje + V_cell_lje + V_end_lje + V_int_uil + V_cell_uil + V_end_uil + V_int_lil + V_cell_lil + V_end_lil)
		V_bc: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|Volume(0.00655721053156776 [l])
		V_bc_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|Volume(0.00100127395361458 [l])
		V_bc_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|Volume(0.000897693889447556 [l])
		V_bc_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|Volume(0.00211763686741475 [l])
		V_bc_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|Volume(0.00186444115500646 [l])
		V_bc_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|Volume(0.00286571510862104 [l])
		V_end: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|Volume(7.95236170849708E-05 [l])
		V_end_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|Volume(1.21431096502194E-05 [l])
		V_end_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|Volume(1.08869258933002E-05 [l])
		V_end_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|Volume(2.56819790303491E-05 [l])
		V_end_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|Volume(2.26113076245465E-05 [l])
		V_end_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|Volume(3.47544172747659E-05 [l])
		V_int: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|Volume(0.054643421096398 [l])
		V_int_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|Volume(0.00688273421469925 [l])
		V_int_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|Volume(0.00470150645864514 [l])
		V_int_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|Volume(0.0110907331844962 [l])
		V_int_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|Volume(0.00945952140837976 [l])
		V_int_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|Volume(0.0164157166614953 [l])
		V_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|Volume(0.512718057521522 [l])
		V_cell_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|Volume(0.00737435808717777 [l])
		V_cell_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|Volume(0.00808071422579633 [l])
		V_cell_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|Volume(0.0190621976608529 [l])
		V_cell_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|Volume(0.0170881677054602 [l])
		V_cell_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|Volume(0.0243890647542217 [l])
		V_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|Volume(0.00739430123772535 [l])
		V_pls_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|Volume(0.001129096160459 [l])
		V_pls_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|Volume(0.00101229310937703 [l])
		V_pls_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|Volume(0.00238797348878684 [l])
		V_pls_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|Volume(0.00210245491947537 [l])
		V_pls_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|Volume(0.00323155107993437 [l])
		M_end_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1-FcRn_Complex(0 [µmol])
		M_end_duo_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		M_end_lil_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		M_end_lje_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		M_end_uil_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		M_end_uje_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		M_int_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		M_int_duo_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		M_int_lil_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		M_int_lje_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		M_int_uil_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		M_int_uje_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		M_pls_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1-FcRn_Complex(0 [µmol])
		M_pls_duo_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		M_pls_lil_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		M_pls_lje_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		M_pls_uil_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		M_pls_uje_Complex: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		M_bc: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells|CDA1(0 [µmol])
		M_bc_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells|CDA1(0 [µmol])
		M_bc_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells|CDA1(0 [µmol])
		M_bc_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells|CDA1(0 [µmol])
		M_bc_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells|CDA1(0 [µmol])
		M_bc_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells|CDA1(0 [µmol])
		M_cell: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular|CDA1(0 [µmol])
		M_cell_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular|CDA1(0 [µmol])
		M_cell_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular|CDA1(0 [µmol])
		M_cell_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular|CDA1(0 [µmol])
		M_cell_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular|CDA1(0 [µmol])
		M_cell_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular|CDA1(0 [µmol])
		M_end: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome|CDA1(0 [µmol])
		M_end_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome|CDA1(0 [µmol])
		M_end_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome|CDA1(0 [µmol])
		M_end_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome|CDA1(0 [µmol])
		M_end_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome|CDA1(0 [µmol])
		M_end_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome|CDA1(0 [µmol])
		M_int: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial|CDA1(0 [µmol])
		M_int_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial|CDA1(0 [µmol])
		M_int_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial|CDA1(0 [µmol])
		M_int_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial|CDA1(0 [µmol])
		M_int_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial|CDA1(0 [µmol])
		M_int_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial|CDA1(0 [µmol])
		M_pls: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma|CDA1(0 [µmol])
		M_pls_duo: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma|CDA1(0 [µmol])
		M_pls_lil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma|CDA1(0 [µmol])
		M_pls_lje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma|CDA1(0 [µmol])
		M_pls_uil: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma|CDA1(0 [µmol])
		M_pls_uje: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma|CDA1(0 [µmol])
		fBloodForSampling: PBPK_model_human_Ab|Organism|SmallIntestine|Fraction of blood for sampling(1)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|Volume(0.00417957744745837 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|Volume(0.00370641773642535 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|Volume(0.0308868144702113 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|Volume(0.289810323007727 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|Volume(4.49501725481372E-05 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|Volume(0.000457394928820579 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|Volume(0.00040561437084089 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume(0.00484612914425286 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Volume(0.000929394630404659 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume(4.91915300807037E-06 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Volume(0.00083855740550307 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|Volume(0.000743626378464987 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume(0.00888457047920524 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Volume(0.00170389022888868 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume(9.01844756861792E-06 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Volume(0.00176291491632691 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|Volume(0.00156333964278046 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume(0.0205119031144955 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Volume(0.0038806303189586 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume(1.8959650986912E-05 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Volume(0.000881457458163453 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|Volume(0.000781669821390232 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume(0.0102559515572477 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Volume(0.0019403151594793 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume(9.47982549345601E-06 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Volume(0.000708314028881347 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|Volume(0.000628127535045722 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume(0.0130303052482889 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Volume(0.00233877273687237 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume(7.61771691438429E-06 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|Volume(0.000288572382136845 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|Volume(0.000255903810574183 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume(0.00469610716213262 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Volume(0.00156536905404421 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume(3.10351429845286E-06 [l])

Observer: Interstitial Unbound
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|CDA1|Interstitial Unbound
	Formula: C_int * K_water_int
		C_int: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|CDA1|Intracellular Unbound
	Formula: C_cell * K_water_cell
		C_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|CDA1|Partition coefficient (water/container)(1.22908131578533)

Observer: Total Tissue (Large Intestine)
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|CDA1|Total Tissue (Large Intestine)
	Formula: (M_int + M_cell + M_end + M_int_cae + M_cell_cae + M_end_cae + M_int_colasc + M_cell_colasc + M_end_colasc + M_int_coltrans + M_cell_coltrans + M_end_coltrans + M_int_coldesc + M_cell_coldesc + M_end_coldesc + M_int_colsigm + M_cell_colsigm + M_end_colsigm + M_int_rect + M_cell_rect + M_end_rect)/(V_int + V_cell + V_end + V_int_cae + V_cell_cae + V_end_cae + V_int_colasc + V_cell_colasc + V_end_colasc + V_int_coltrans + V_cell_coltrans + V_end_coltrans + V_int_coldesc + V_cell_coldesc + V_end_coldesc + V_int_colsigm + V_cell_colsigm + V_end_colsigm + V_int_rect + V_cell_rect + V_end_rect)
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|Volume(4.49501725481372E-05 [l])
		V_end_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume(4.91915300807037E-06 [l])
		V_end_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume(9.01844756861792E-06 [l])
		V_end_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume(9.47982549345601E-06 [l])
		V_end_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume(7.61771691438429E-06 [l])
		V_end_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume(1.8959650986912E-05 [l])
		V_end_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume(3.10351429845286E-06 [l])
		V_int: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|Volume(0.0308868144702113 [l])
		V_int_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume(0.00484612914425286 [l])
		V_int_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume(0.00888457047920524 [l])
		V_int_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume(0.0102559515572477 [l])
		V_int_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume(0.0130303052482889 [l])
		V_int_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume(0.0205119031144955 [l])
		V_int_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume(0.00469610716213262 [l])
		V_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|Volume(0.289810323007727 [l])
		V_cell_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Volume(0.000929394630404659 [l])
		V_cell_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Volume(0.00170389022888868 [l])
		V_cell_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Volume(0.0019403151594793 [l])
		V_cell_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Volume(0.00233877273687237 [l])
		V_cell_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Volume(0.0038806303189586 [l])
		V_cell_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Volume(0.00156536905404421 [l])
		M_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|CDA1(0 [µmol])
		M_cell_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|CDA1(0 [µmol])
		M_cell_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|CDA1(0 [µmol])
		M_cell_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|CDA1(0 [µmol])
		M_cell_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|CDA1(0 [µmol])
		M_cell_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|CDA1(0 [µmol])
		M_cell_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|CDA1(0 [µmol])
		M_end: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1(0 [µmol])
		M_end_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1(0 [µmol])
		M_end_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1(0 [µmol])
		M_end_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1(0 [µmol])
		M_end_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1(0 [µmol])
		M_end_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1(0 [µmol])
		M_end_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1(0 [µmol])
		M_int: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1(0 [µmol])
		M_int_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1(0 [µmol])
		M_int_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1(0 [µmol])
		M_int_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1(0 [µmol])
		M_int_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1(0 [µmol])
		M_int_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1(0 [µmol])
		M_int_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1(0 [µmol])

Observer: Whole Organ (Large Intestine)
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|CDA1|Whole Organ (Large Intestine)
	Formula: (fBloodForSampling*(M_pls + M_bc + M_pls_cae + M_bc_cae + M_pls_colasc + M_bc_colasc + M_pls_coltrans + M_bc_coltrans + M_pls_coldesc + M_bc_coldesc + M_pls_colsigm + M_bc_colsigm + M_pls_rect + M_bc_rect)+M_int + M_cell + M_end + M_int_cae + M_cell_cae + M_end_cae + M_int_colasc + M_cell_colasc + M_end_colasc + M_int_coltrans + M_cell_coltrans + M_end_coltrans + M_int_coldesc + M_cell_coldesc + M_end_coldesc + M_int_colsigm + M_cell_colsigm + M_end_colsigm + M_int_rect + M_cell_rect + M_end_rect)/(fBloodForSampling*(V_pls + V_bc + V_pls_cae + V_bc_cae + V_pls_colasc + V_bc_colasc + V_pls_coltrans + V_bc_coltrans + V_pls_coldesc + V_bc_coldesc + V_pls_colsigm + V_bc_colsigm + V_pls_rect + V_bc_rect) + V_int + V_cell + V_end + V_int_cae + V_cell_cae + V_end_cae + V_int_colasc + V_cell_colasc + V_end_colasc + V_int_coltrans + V_cell_coltrans + V_end_coltrans + V_int_coldesc + V_cell_coldesc + V_end_coldesc + V_int_colsigm + V_cell_colsigm + V_end_colsigm + V_int_rect + V_cell_rect + V_end_rect)
		V_bc: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|Volume(0.00370641773642535 [l])
		V_bc_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|Volume(0.00040561437084089 [l])
		V_bc_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|Volume(0.000743626378464987 [l])
		V_bc_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|Volume(0.000781669821390232 [l])
		V_bc_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|Volume(0.000628127535045722 [l])
		V_bc_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|Volume(0.00156333964278046 [l])
		V_bc_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|Volume(0.000255903810574183 [l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|Volume(4.49501725481372E-05 [l])
		V_end_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume(4.91915300807037E-06 [l])
		V_end_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume(9.01844756861792E-06 [l])
		V_end_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume(9.47982549345601E-06 [l])
		V_end_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume(7.61771691438429E-06 [l])
		V_end_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume(1.8959650986912E-05 [l])
		V_end_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume(3.10351429845286E-06 [l])
		V_int: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|Volume(0.0308868144702113 [l])
		V_int_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume(0.00484612914425286 [l])
		V_int_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume(0.00888457047920524 [l])
		V_int_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume(0.0102559515572477 [l])
		V_int_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume(0.0130303052482889 [l])
		V_int_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume(0.0205119031144955 [l])
		V_int_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume(0.00469610716213262 [l])
		V_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|Volume(0.289810323007727 [l])
		V_cell_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Volume(0.000929394630404659 [l])
		V_cell_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Volume(0.00170389022888868 [l])
		V_cell_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Volume(0.0019403151594793 [l])
		V_cell_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Volume(0.00233877273687237 [l])
		V_cell_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Volume(0.0038806303189586 [l])
		V_cell_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Volume(0.00156536905404421 [l])
		V_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|Volume(0.00417957744745837 [l])
		V_pls_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|Volume(0.000457394928820579 [l])
		V_pls_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Volume(0.00083855740550307 [l])
		V_pls_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Volume(0.000881457458163453 [l])
		V_pls_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Volume(0.000708314028881347 [l])
		V_pls_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Volume(0.00176291491632691 [l])
		V_pls_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|Volume(0.000288572382136845 [l])
		M_bc: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1(0 [µmol])
		M_bc_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|CDA1(0 [µmol])
		M_bc_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|CDA1(0 [µmol])
		M_bc_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|CDA1(0 [µmol])
		M_bc_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|CDA1(0 [µmol])
		M_bc_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|CDA1(0 [µmol])
		M_bc_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|CDA1(0 [µmol])
		M_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|CDA1(0 [µmol])
		M_cell_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|CDA1(0 [µmol])
		M_cell_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|CDA1(0 [µmol])
		M_cell_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|CDA1(0 [µmol])
		M_cell_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|CDA1(0 [µmol])
		M_cell_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|CDA1(0 [µmol])
		M_cell_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|CDA1(0 [µmol])
		M_end: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1(0 [µmol])
		M_end_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1(0 [µmol])
		M_end_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1(0 [µmol])
		M_end_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1(0 [µmol])
		M_end_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1(0 [µmol])
		M_end_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1(0 [µmol])
		M_end_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1(0 [µmol])
		M_int: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1(0 [µmol])
		M_int_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1(0 [µmol])
		M_int_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1(0 [µmol])
		M_int_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1(0 [µmol])
		M_int_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1(0 [µmol])
		M_int_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1(0 [µmol])
		M_int_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1(0 [µmol])
		M_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1(0 [µmol])
		M_pls_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1(0 [µmol])
		M_pls_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1(0 [µmol])
		M_pls_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1(0 [µmol])
		M_pls_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1(0 [µmol])
		M_pls_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1(0 [µmol])
		M_pls_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1(0 [µmol])
		fBloodForSampling: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction of blood for sampling(1)

Observer: Whole Organ (Large Intestine) incl. FcRn_Complex-CDA1
	Path: PBPK_model_human_Ab|Organism|LargeIntestine|CDA1|Whole Organ (Large Intestine) incl. FcRn_Complex-CDA1
	Formula: (fBloodForSampling*(M_pls+M_pls_Complex + M_bc + M_pls_cae+M_pls_cae_Complex + M_bc_cae + M_pls_colasc+M_pls_colasc_Complex + M_bc_colasc + M_pls_coltrans+M_pls_coltrans_Complex + M_bc_coltrans + M_pls_coldesc+M_pls_coldesc_Complex + M_bc_coldesc + M_pls_colsigm+M_pls_colsigm_Complex + M_bc_colsigm + M_pls_rect+M_pls_rect_Complex + M_bc_rect)+M_int+M_int_Complex + M_cell + M_end+M_end_Complex + M_int_cae+M_int_cae_Complex + M_cell_cae + M_end_cae+M_end_cae_Complex + M_int_colasc+M_int_colasc_Complex + M_cell_colasc + M_end_colasc+M_end_colasc_Complex + M_int_coltrans+M_int_coltrans_Complex + M_cell_coltrans + M_end_coltrans+M_end_coltrans_Complex + M_int_coldesc+M_int_coldesc_Complex + M_cell_coldesc + M_end_coldesc+M_end_coldesc_Complex + M_int_colsigm+M_int_colsigm_Complex + M_cell_colsigm + M_end_colsigm+M_end_colsigm_Complex + M_int_rect+M_int_rect_Complex + M_cell_rect + M_end_rect+M_end_rect_Complex)/(fBloodForSampling*(V_pls + V_bc + V_pls_cae + V_bc_cae + V_pls_colasc + V_bc_colasc + V_pls_coltrans + V_bc_coltrans + V_pls_coldesc + V_bc_coldesc + V_pls_colsigm + V_bc_colsigm + V_pls_rect + V_bc_rect) + V_int + V_cell + V_end + V_int_cae + V_cell_cae + V_end_cae + V_int_colasc + V_cell_colasc + V_end_colasc + V_int_coltrans + V_cell_coltrans + V_end_coltrans + V_int_coldesc + V_cell_coldesc + V_end_coldesc + V_int_colsigm + V_cell_colsigm + V_end_colsigm + V_int_rect + V_cell_rect + V_end_rect)
		V_bc: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|Volume(0.00370641773642535 [l])
		V_bc_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|Volume(0.00040561437084089 [l])
		V_bc_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|Volume(0.000743626378464987 [l])
		V_bc_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|Volume(0.000781669821390232 [l])
		V_bc_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|Volume(0.000628127535045722 [l])
		V_bc_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|Volume(0.00156333964278046 [l])
		V_bc_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|Volume(0.000255903810574183 [l])
		V_end: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|Volume(4.49501725481372E-05 [l])
		V_end_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|Volume(4.91915300807037E-06 [l])
		V_end_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|Volume(9.01844756861792E-06 [l])
		V_end_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|Volume(9.47982549345601E-06 [l])
		V_end_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|Volume(7.61771691438429E-06 [l])
		V_end_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|Volume(1.8959650986912E-05 [l])
		V_end_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|Volume(3.10351429845286E-06 [l])
		V_int: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|Volume(0.0308868144702113 [l])
		V_int_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|Volume(0.00484612914425286 [l])
		V_int_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|Volume(0.00888457047920524 [l])
		V_int_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|Volume(0.0102559515572477 [l])
		V_int_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|Volume(0.0130303052482889 [l])
		V_int_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|Volume(0.0205119031144955 [l])
		V_int_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|Volume(0.00469610716213262 [l])
		V_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|Volume(0.289810323007727 [l])
		V_cell_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|Volume(0.000929394630404659 [l])
		V_cell_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|Volume(0.00170389022888868 [l])
		V_cell_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|Volume(0.0019403151594793 [l])
		V_cell_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|Volume(0.00233877273687237 [l])
		V_cell_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|Volume(0.0038806303189586 [l])
		V_cell_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|Volume(0.00156536905404421 [l])
		V_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|Volume(0.00417957744745837 [l])
		V_pls_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|Volume(0.000457394928820579 [l])
		V_pls_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|Volume(0.00083855740550307 [l])
		V_pls_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|Volume(0.000881457458163453 [l])
		V_pls_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|Volume(0.000708314028881347 [l])
		V_pls_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|Volume(0.00176291491632691 [l])
		V_pls_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|Volume(0.000288572382136845 [l])
		M_end_cae_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		M_end_colasc_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1-FcRn_Complex(0 [µmol])
		M_end_coldesc_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1-FcRn_Complex(0 [µmol])
		M_end_colsigm_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1-FcRn_Complex(0 [µmol])
		M_end_coltrans_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		M_end_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1-FcRn_Complex(0 [µmol])
		M_end_rect_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1-FcRn_Complex(0 [µmol])
		M_int_cae_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		M_int_colasc_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		M_int_coldesc_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		M_int_colsigm_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		M_int_coltrans_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		M_int_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		M_int_rect_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1-FcRn_Complex(0 [µmol])
		M_pls_cae_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		M_pls_colasc_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1-FcRn_Complex(0 [µmol])
		M_pls_coldesc_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1-FcRn_Complex(0 [µmol])
		M_pls_colsigm_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1-FcRn_Complex(0 [µmol])
		M_pls_coltrans_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		M_pls_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1-FcRn_Complex(0 [µmol])
		M_pls_rect_Complex: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1-FcRn_Complex(0 [µmol])
		M_bc: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells|CDA1(0 [µmol])
		M_bc_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells|CDA1(0 [µmol])
		M_bc_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells|CDA1(0 [µmol])
		M_bc_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells|CDA1(0 [µmol])
		M_bc_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells|CDA1(0 [µmol])
		M_bc_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells|CDA1(0 [µmol])
		M_bc_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells|CDA1(0 [µmol])
		M_cell: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular|CDA1(0 [µmol])
		M_cell_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular|CDA1(0 [µmol])
		M_cell_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular|CDA1(0 [µmol])
		M_cell_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular|CDA1(0 [µmol])
		M_cell_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular|CDA1(0 [µmol])
		M_cell_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular|CDA1(0 [µmol])
		M_cell_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular|CDA1(0 [µmol])
		M_end: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome|CDA1(0 [µmol])
		M_end_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome|CDA1(0 [µmol])
		M_end_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome|CDA1(0 [µmol])
		M_end_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome|CDA1(0 [µmol])
		M_end_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome|CDA1(0 [µmol])
		M_end_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome|CDA1(0 [µmol])
		M_end_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome|CDA1(0 [µmol])
		M_int: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial|CDA1(0 [µmol])
		M_int_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial|CDA1(0 [µmol])
		M_int_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial|CDA1(0 [µmol])
		M_int_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial|CDA1(0 [µmol])
		M_int_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial|CDA1(0 [µmol])
		M_int_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial|CDA1(0 [µmol])
		M_int_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial|CDA1(0 [µmol])
		M_pls: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma|CDA1(0 [µmol])
		M_pls_cae: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma|CDA1(0 [µmol])
		M_pls_colasc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma|CDA1(0 [µmol])
		M_pls_coldesc: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma|CDA1(0 [µmol])
		M_pls_colsigm: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma|CDA1(0 [µmol])
		M_pls_coltrans: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma|CDA1(0 [µmol])
		M_pls_rect: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma|CDA1(0 [µmol])
		fBloodForSampling: PBPK_model_human_Ab|Organism|LargeIntestine|Fraction of blood for sampling(1)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|Volume(0.214130936164388 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|Volume(0.189889698108042 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|Volume(0.387384490508271 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|Volume(1.58518684152771 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume(0.00230291761535285 [l])

Observer: Interstitial Unbound
	Path: PBPK_model_human_Ab|Organism|Liver|Periportal|CDA1|Interstitial Unbound
	Formula: C_int * K_water_int
		C_int: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound
	Path: PBPK_model_human_Ab|Organism|Liver|Periportal|CDA1|Intracellular Unbound
	Formula: C_cell * K_water_cell
		C_cell: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1|Partition coefficient (water/container)(1.28715961852841)

Observer: Tissue
	Path: PBPK_model_human_Ab|Organism|Liver|Periportal|CDA1|Tissue
	Formula: (V_int*C_int+V_cell*C_cell+V_end*C_end)/(V_int+V_cell+V_end)
		V_end: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume(0.00230291761535285 [l])
		V_int: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|Volume(0.387384490508271 [l])
		V_cell: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|Volume(1.58518684152771 [l])
		C_cell: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Concentration(0 [µmol/l])

Observer: Whole Organ
	Path: PBPK_model_human_Ab|Organism|Liver|Periportal|CDA1|Whole Organ
	Formula: (fBloodForSampling*(V_pls*C_pls + V_bc*C_bc) + V_end*C_end + V_int*C_int + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|Volume(0.189889698108042 [l])
		V_end: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume(0.00230291761535285 [l])
		V_int: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|Volume(0.387384490508271 [l])
		V_cell: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|Volume(1.58518684152771 [l])
		V_pls: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|Volume(0.214130936164388 [l])
		C_bc: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Whole Organ incl. FcRn_Complex-CDA1
	Path: PBPK_model_human_Ab|Organism|Liver|Periportal|CDA1|Whole Organ incl. FcRn_Complex-CDA1
	Formula: (fBloodForSampling*(V_pls*(C_pls+C_pls_Complex) + V_bc*C_bc) + V_end*(C_end+C_end_Complex) + V_int*(C_int+C_int_Complex) + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Liver|Periportal|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|Volume(0.189889698108042 [l])
		V_end: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume(0.00230291761535285 [l])
		V_int: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|Volume(0.387384490508271 [l])
		V_cell: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|Volume(1.58518684152771 [l])
		V_pls: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|Volume(0.214130936164388 [l])
		C_end_Complex: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_int_Complex: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_pls_Complex: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_bc: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|Volume(0 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|Volume(0 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|Volume(0 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|Volume(0 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume(0 [l])

Observer: Interstitial Unbound
	Path: PBPK_model_human_Ab|Organism|Liver|Pericentral|CDA1|Interstitial Unbound
	Formula: C_int * K_water_int
		C_int: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound
	Path: PBPK_model_human_Ab|Organism|Liver|Pericentral|CDA1|Intracellular Unbound
	Formula: C_cell * K_water_cell
		C_cell: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1|Partition coefficient (water/container)(1.28715961852841)

Observer: Tissue
	Path: PBPK_model_human_Ab|Organism|Liver|Pericentral|CDA1|Tissue
	Formula: (V_int*C_int+V_cell*C_cell+V_end*C_end)/(V_int+V_cell+V_end)
		V_end: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume(0 [l])
		V_int: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|Volume(0 [l])
		V_cell: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|Volume(0 [l])
		C_cell: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Concentration(0 [µmol/l])

Observer: Whole Organ
	Path: PBPK_model_human_Ab|Organism|Liver|Pericentral|CDA1|Whole Organ
	Formula: (fBloodForSampling*(V_pls*C_pls + V_bc*C_bc) + V_end*C_end + V_int*C_int + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|Volume(0 [l])
		V_end: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume(0 [l])
		V_int: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|Volume(0 [l])
		V_cell: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|Volume(0 [l])
		V_pls: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|Volume(0 [l])
		C_bc: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Whole Organ incl. FcRn_Complex-CDA1
	Path: PBPK_model_human_Ab|Organism|Liver|Pericentral|CDA1|Whole Organ incl. FcRn_Complex-CDA1
	Formula: (fBloodForSampling*(V_pls*(C_pls+C_pls_Complex) + V_bc*C_bc) + V_end*(C_end+C_end_Complex) + V_int*(C_int+C_int_Complex) + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Liver|Pericentral|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|Volume(0 [l])
		V_end: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume(0 [l])
		V_int: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|Volume(0 [l])
		V_cell: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|Volume(0 [l])
		V_pls: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|Volume(0 [l])
		C_end_Complex: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_int_Complex: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_pls_Complex: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_bc: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in container (Liver, Plasma)
	Path: PBPK_model_human_Ab|Organism|Liver|Plasma|CDA1|Concentration in container (Liver, Plasma)
	Formula: (C_pls_prp * V_pls_prp + C_pls_prc * V_pls_prc)/(V_pls_prp+V_pls_prc)
		V_pls_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|Volume(0 [l])
		V_pls_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|Volume(0.214130936164388 [l])
		C_pls_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1|Concentration(0 [µmol/l])
		C_pls_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1|Concentration(0 [µmol/l])

Observer: Concentration in container (Liver, BloodCells)
	Path: PBPK_model_human_Ab|Organism|Liver|BloodCells|CDA1|Concentration in container (Liver, BloodCells)
	Formula: (C_bc_prp * V_bc_prp + C_bc_prc * V_bc_prc)/(V_bc_prp+V_bc_prc)
		V_bc_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|Volume(0 [l])
		V_bc_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|Volume(0.189889698108042 [l])
		C_bc_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_bc_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1|Concentration(0 [µmol/l])

Observer: Concentration in container (Liver, Interstitial)
	Path: PBPK_model_human_Ab|Organism|Liver|Interstitial|CDA1|Concentration in container (Liver, Interstitial)
	Formula: (C_int_prp * V_int_prp + C_int_prc * V_int_prc)/(V_int_prp+V_int_prc)
		V_int_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|Volume(0 [l])
		V_int_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|Volume(0.387384490508271 [l])
		C_int_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_int_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Concentration(0 [µmol/l])

Observer: Concentration in container (Liver, Intracellular)
	Path: PBPK_model_human_Ab|Organism|Liver|Intracellular|CDA1|Concentration in container (Liver, Intracellular)
	Formula: (C_cell_prp * V_cell_prp + C_cell_prc * V_cell_prc)/(V_cell_prp+V_cell_prc)
		V_cell_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|Volume(0 [l])
		V_cell_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|Volume(1.58518684152771 [l])
		C_cell_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_cell_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1|Concentration(0 [µmol/l])

Observer: Concentration in container (Liver, Endosome)
	Path: PBPK_model_human_Ab|Organism|Liver|Endosome|CDA1|Concentration in container (Liver, Endosome)
	Formula: (C_end_prp * V_end_prp + C_end_prc * V_end_prc)/(V_end_prp+V_end_prc)
		V_end_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume(0 [l])
		V_end_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume(0.00230291761535285 [l])
		C_end_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1|Concentration(0 [µmol/l])
		C_end_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1|Concentration(0 [µmol/l])

Observer: Interstitial Unbound (Liver)
	Path: PBPK_model_human_Ab|Organism|Liver|CDA1|Interstitial Unbound (Liver)
	Formula: (C_int_prp * K_water_int_prp * V_int_prp + C_int_prc * K_water_int_prc * V_int_prc)/(V_int_prp+V_int_prc)
		V_int_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|Volume(0 [l])
		V_int_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|Volume(0.387384490508271 [l])
		C_int_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_int_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)
		K_water_int_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound (Liver)
	Path: PBPK_model_human_Ab|Organism|Liver|CDA1|Intracellular Unbound (Liver)
	Formula: (C_cell_prp * K_water_cell_prp * V_cell_prp + C_cell_prc * K_water_cell_prc * V_cell_prc)/(V_cell_prp+V_cell_prc)
		V_cell_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|Volume(0 [l])
		V_cell_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|Volume(1.58518684152771 [l])
		C_cell_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_cell_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1|Partition coefficient (water/container)(1.28715961852841)
		K_water_cell_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1|Partition coefficient (water/container)(1.28715961852841)

Observer: Tissue (Liver)
	Path: PBPK_model_human_Ab|Organism|Liver|CDA1|Tissue (Liver)
	Formula: (C_int_prp * V_int_prp + C_int_prc * V_int_prc + C_cell_prp * V_cell_prp + C_cell_prc * V_cell_prc + C_end_prp * V_end_prp + C_end_prc * V_end_prc)/(V_int_prp+V_int_prc+V_cell_prp+V_cell_prc+V_end_prp+V_end_prc)
		V_end_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume(0 [l])
		V_end_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume(0.00230291761535285 [l])
		V_int_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|Volume(0 [l])
		V_int_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|Volume(0.387384490508271 [l])
		V_cell_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|Volume(0 [l])
		V_cell_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|Volume(1.58518684152771 [l])
		C_cell_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_cell_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1|Concentration(0 [µmol/l])
		C_end_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_int_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Concentration(0 [µmol/l])

Observer: Whole Organ (Liver)
	Path: PBPK_model_human_Ab|Organism|Liver|CDA1|Whole Organ (Liver)
	Formula: (fBloodForSampling*(C_pls_prp * V_pls_prp + C_pls_prc * V_pls_prc + C_bc_prp * V_bc_prp + C_bc_prc * V_bc_prc) + C_int_prp * V_int_prp + C_int_prc * V_int_prc + C_cell_prp * V_cell_prp + C_cell_prc * V_cell_prc + C_end_prp * V_end_prp + C_end_prc * V_end_prc)/(fBloodForSampling*(V_pls_prp+V_pls_prc+V_bc_prp+V_bc_prc)+V_int_prp+V_int_prc+V_cell_prp+V_cell_prc+V_end_prp+V_end_prc)
		V_bc_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|Volume(0 [l])
		V_bc_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|Volume(0.189889698108042 [l])
		V_end_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume(0 [l])
		V_end_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume(0.00230291761535285 [l])
		V_int_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|Volume(0 [l])
		V_int_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|Volume(0.387384490508271 [l])
		V_cell_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|Volume(0 [l])
		V_cell_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|Volume(1.58518684152771 [l])
		V_pls_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|Volume(0 [l])
		V_pls_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|Volume(0.214130936164388 [l])
		C_bc_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_bc_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_cell_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1|Concentration(0 [µmol/l])
		C_end_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_int_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1|Concentration(0 [µmol/l])
		C_pls_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1|Concentration(0 [µmol/l])
		fBloodForSampling: PBPK_model_human_Ab|Organism|Liver|Fraction of blood for sampling(1)

Observer: Whole Organ incl. FcRn_Complex (Liver)-CDA1
	Path: PBPK_model_human_Ab|Organism|Liver|CDA1|Whole Organ incl. FcRn_Complex (Liver)-CDA1
	Formula: (fBloodForSampling*((C_pls_prp + C_pls_prp_Complex) * V_pls_prp + (C_pls_prc + C_pls_prc_Complex) * V_pls_prc +  C_bc_prp * V_bc_prp + C_bc_prc * V_bc_prc) +  (C_int_prp + C_int_prp_Complex) * V_int_prp + (C_int_prc + C_int_prc_Complex) * V_int_prc + C_cell_prp * V_cell_prp + C_cell_prc * V_cell_prc + (C_end_prp + C_end_prp_Complex) * V_end_prp + (C_end_prc + C_end_prc_Complex) * V_end_prc)/(fBloodForSampling*(V_pls_prp+V_pls_prc+V_bc_prp+V_bc_prc)+V_int_prp+V_int_prc+V_cell_prp+V_cell_prc+V_end_prp+V_end_prc)
		V_bc_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|Volume(0 [l])
		V_bc_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|Volume(0.189889698108042 [l])
		V_end_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|Volume(0 [l])
		V_end_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|Volume(0.00230291761535285 [l])
		V_int_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|Volume(0 [l])
		V_int_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|Volume(0.387384490508271 [l])
		V_cell_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|Volume(0 [l])
		V_cell_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|Volume(1.58518684152771 [l])
		V_pls_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|Volume(0 [l])
		V_pls_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|Volume(0.214130936164388 [l])
		C_end_prc_Complex: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_end_prp_Complex: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_int_prc_Complex: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_int_prp_Complex: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_pls_prc_Complex: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_pls_prp_Complex: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_bc_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_bc_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_cell_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome|CDA1|Concentration(0 [µmol/l])
		C_end_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_int_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls_prc: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma|CDA1|Concentration(0 [µmol/l])
		C_pls_prp: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma|CDA1|Concentration(0 [µmol/l])
		fBloodForSampling: PBPK_model_human_Ab|Organism|Liver|Fraction of blood for sampling(1)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lung|Plasma|Volume(0.373299674376007 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Lung|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lung|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lung|BloodCells|Volume(0.33103933388061 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lung|Interstitial|Volume(0.228302988883179 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Lung|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lung|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lung|Intracellular|Volume(0.281735603302647 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Lung|Endosome|Volume(0.00401473234706272 [l])

Observer: Interstitial Unbound
	Path: PBPK_model_human_Ab|Organism|Lung|CDA1|Interstitial Unbound
	Formula: C_int * K_water_int
		C_int: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound
	Path: PBPK_model_human_Ab|Organism|Lung|CDA1|Intracellular Unbound
	Formula: C_cell * K_water_cell
		C_cell: PBPK_model_human_Ab|Organism|Lung|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell: PBPK_model_human_Ab|Organism|Lung|Intracellular|CDA1|Partition coefficient (water/container)(1.19511249832262)

Observer: Tissue
	Path: PBPK_model_human_Ab|Organism|Lung|CDA1|Tissue
	Formula: (V_int*C_int+V_cell*C_cell+V_end*C_end)/(V_int+V_cell+V_end)
		V_end: PBPK_model_human_Ab|Organism|Lung|Endosome|Volume(0.00401473234706272 [l])
		V_int: PBPK_model_human_Ab|Organism|Lung|Interstitial|Volume(0.228302988883179 [l])
		V_cell: PBPK_model_human_Ab|Organism|Lung|Intracellular|Volume(0.281735603302647 [l])
		C_cell: PBPK_model_human_Ab|Organism|Lung|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1|Concentration(0 [µmol/l])

Observer: Whole Organ
	Path: PBPK_model_human_Ab|Organism|Lung|CDA1|Whole Organ
	Formula: (fBloodForSampling*(V_pls*C_pls + V_bc*C_bc) + V_end*C_end + V_int*C_int + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Lung|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Lung|BloodCells|Volume(0.33103933388061 [l])
		V_end: PBPK_model_human_Ab|Organism|Lung|Endosome|Volume(0.00401473234706272 [l])
		V_int: PBPK_model_human_Ab|Organism|Lung|Interstitial|Volume(0.228302988883179 [l])
		V_cell: PBPK_model_human_Ab|Organism|Lung|Intracellular|Volume(0.281735603302647 [l])
		V_pls: PBPK_model_human_Ab|Organism|Lung|Plasma|Volume(0.373299674376007 [l])
		C_bc: PBPK_model_human_Ab|Organism|Lung|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Lung|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Whole Organ incl. FcRn_Complex-CDA1
	Path: PBPK_model_human_Ab|Organism|Lung|CDA1|Whole Organ incl. FcRn_Complex-CDA1
	Formula: (fBloodForSampling*(V_pls*(C_pls+C_pls_Complex) + V_bc*C_bc) + V_end*(C_end+C_end_Complex) + V_int*(C_int+C_int_Complex) + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Lung|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Lung|BloodCells|Volume(0.33103933388061 [l])
		V_end: PBPK_model_human_Ab|Organism|Lung|Endosome|Volume(0.00401473234706272 [l])
		V_int: PBPK_model_human_Ab|Organism|Lung|Interstitial|Volume(0.228302988883179 [l])
		V_cell: PBPK_model_human_Ab|Organism|Lung|Intracellular|Volume(0.281735603302647 [l])
		V_pls: PBPK_model_human_Ab|Organism|Lung|Plasma|Volume(0.373299674376007 [l])
		C_end_Complex: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_int_Complex: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_pls_Complex: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_bc: PBPK_model_human_Ab|Organism|Lung|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Lung|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Lung|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Lung|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Lung|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Muscle|Plasma|Volume(0.432483065940599 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Muscle|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Muscle|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Muscle|BloodCells|Volume(0.383522718852984 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Muscle|Interstitial|Volume(5.22243702267893 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Muscle|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Muscle|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Muscle|Intracellular|Volume(26.6017885842708 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Muscle|Endosome|Volume(0.00465123297332342 [l])

Observer: Interstitial Unbound
	Path: PBPK_model_human_Ab|Organism|Muscle|CDA1|Interstitial Unbound
	Formula: C_int * K_water_int
		C_int: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound
	Path: PBPK_model_human_Ab|Organism|Muscle|CDA1|Intracellular Unbound
	Formula: C_cell * K_water_cell
		C_cell: PBPK_model_human_Ab|Organism|Muscle|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell: PBPK_model_human_Ab|Organism|Muscle|Intracellular|CDA1|Partition coefficient (water/container)(1.19080760296443)

Observer: Tissue
	Path: PBPK_model_human_Ab|Organism|Muscle|CDA1|Tissue
	Formula: (V_int*C_int+V_cell*C_cell+V_end*C_end)/(V_int+V_cell+V_end)
		V_end: PBPK_model_human_Ab|Organism|Muscle|Endosome|Volume(0.00465123297332342 [l])
		V_int: PBPK_model_human_Ab|Organism|Muscle|Interstitial|Volume(5.22243702267893 [l])
		V_cell: PBPK_model_human_Ab|Organism|Muscle|Intracellular|Volume(26.6017885842708 [l])
		C_cell: PBPK_model_human_Ab|Organism|Muscle|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1|Concentration(0 [µmol/l])

Observer: Whole Organ
	Path: PBPK_model_human_Ab|Organism|Muscle|CDA1|Whole Organ
	Formula: (fBloodForSampling*(V_pls*C_pls + V_bc*C_bc) + V_end*C_end + V_int*C_int + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Muscle|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Muscle|BloodCells|Volume(0.383522718852984 [l])
		V_end: PBPK_model_human_Ab|Organism|Muscle|Endosome|Volume(0.00465123297332342 [l])
		V_int: PBPK_model_human_Ab|Organism|Muscle|Interstitial|Volume(5.22243702267893 [l])
		V_cell: PBPK_model_human_Ab|Organism|Muscle|Intracellular|Volume(26.6017885842708 [l])
		V_pls: PBPK_model_human_Ab|Organism|Muscle|Plasma|Volume(0.432483065940599 [l])
		C_bc: PBPK_model_human_Ab|Organism|Muscle|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Muscle|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Whole Organ incl. FcRn_Complex-CDA1
	Path: PBPK_model_human_Ab|Organism|Muscle|CDA1|Whole Organ incl. FcRn_Complex-CDA1
	Formula: (fBloodForSampling*(V_pls*(C_pls+C_pls_Complex) + V_bc*C_bc) + V_end*(C_end+C_end_Complex) + V_int*(C_int+C_int_Complex) + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Muscle|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Muscle|BloodCells|Volume(0.383522718852984 [l])
		V_end: PBPK_model_human_Ab|Organism|Muscle|Endosome|Volume(0.00465123297332342 [l])
		V_int: PBPK_model_human_Ab|Organism|Muscle|Interstitial|Volume(5.22243702267893 [l])
		V_cell: PBPK_model_human_Ab|Organism|Muscle|Intracellular|Volume(26.6017885842708 [l])
		V_pls: PBPK_model_human_Ab|Organism|Muscle|Plasma|Volume(0.432483065940599 [l])
		C_end_Complex: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_int_Complex: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_pls_Complex: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_bc: PBPK_model_human_Ab|Organism|Muscle|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Muscle|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Muscle|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Muscle|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Muscle|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Pancreas|Plasma|Volume(0.0201864473139155 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|Volume(0.0179011891274345 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|Volume(0.02285258186481 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|Volume(0.12949796390059 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Pancreas|Endosome|Volume(0.000217099527715695 [l])

Observer: Interstitial Unbound
	Path: PBPK_model_human_Ab|Organism|Pancreas|CDA1|Interstitial Unbound
	Formula: C_int * K_water_int
		C_int: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound
	Path: PBPK_model_human_Ab|Organism|Pancreas|CDA1|Intracellular Unbound
	Formula: C_cell * K_water_cell
		C_cell: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|CDA1|Partition coefficient (water/container)(1.36774874200018)

Observer: Tissue
	Path: PBPK_model_human_Ab|Organism|Pancreas|CDA1|Tissue
	Formula: (V_int*C_int+V_cell*C_cell+V_end*C_end)/(V_int+V_cell+V_end)
		V_end: PBPK_model_human_Ab|Organism|Pancreas|Endosome|Volume(0.000217099527715695 [l])
		V_int: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|Volume(0.02285258186481 [l])
		V_cell: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|Volume(0.12949796390059 [l])
		C_cell: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1|Concentration(0 [µmol/l])

Observer: Whole Organ
	Path: PBPK_model_human_Ab|Organism|Pancreas|CDA1|Whole Organ
	Formula: (fBloodForSampling*(V_pls*C_pls + V_bc*C_bc) + V_end*C_end + V_int*C_int + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Pancreas|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|Volume(0.0179011891274345 [l])
		V_end: PBPK_model_human_Ab|Organism|Pancreas|Endosome|Volume(0.000217099527715695 [l])
		V_int: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|Volume(0.02285258186481 [l])
		V_cell: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|Volume(0.12949796390059 [l])
		V_pls: PBPK_model_human_Ab|Organism|Pancreas|Plasma|Volume(0.0201864473139155 [l])
		C_bc: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Whole Organ incl. FcRn_Complex-CDA1
	Path: PBPK_model_human_Ab|Organism|Pancreas|CDA1|Whole Organ incl. FcRn_Complex-CDA1
	Formula: (fBloodForSampling*(V_pls*(C_pls+C_pls_Complex) + V_bc*C_bc) + V_end*(C_end+C_end_Complex) + V_int*(C_int+C_int_Complex) + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Pancreas|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|Volume(0.0179011891274345 [l])
		V_end: PBPK_model_human_Ab|Organism|Pancreas|Endosome|Volume(0.000217099527715695 [l])
		V_int: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|Volume(0.02285258186481 [l])
		V_cell: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|Volume(0.12949796390059 [l])
		V_pls: PBPK_model_human_Ab|Organism|Pancreas|Plasma|Volume(0.0201864473139155 [l])
		C_end_Complex: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_int_Complex: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_pls_Complex: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_bc: PBPK_model_human_Ab|Organism|Pancreas|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Pancreas|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Pancreas|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Pancreas|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Pancreas|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|PortalVein|Plasma|Volume(0.549841357705713 [l])

Observer: Plasma Unbound
	Path: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1|Plasma Unbound
	Formula: C_pls*fu
		C_pls: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1|Concentration(0 [µmol/l])
		fu: PBPK_model_human_Ab|CDA1|Fraction unbound (plasma)(1)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|Volume(0.48759516626733 [l])

Observer: Whole Blood
	Path: PBPK_model_human_Ab|Organism|PortalVein|CDA1|Whole Blood
	Formula: (1 - HCT) * C_pls+HCT * C_bc
		C_bc: PBPK_model_human_Ab|Organism|PortalVein|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|PortalVein|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Skin|Plasma|Volume(0.0917406640016164 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Skin|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Skin|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Skin|BloodCells|Volume(0.0813549284542636 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Skin|Interstitial|Volume(1.13641019394947 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Skin|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Skin|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Skin|Intracellular|Volume(2.45344187567899 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Skin|Endosome|Volume(0.000986644876998516 [l])

Observer: Interstitial Unbound
	Path: PBPK_model_human_Ab|Organism|Skin|CDA1|Interstitial Unbound
	Formula: C_int * K_water_int
		C_int: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound
	Path: PBPK_model_human_Ab|Organism|Skin|CDA1|Intracellular Unbound
	Formula: C_cell * K_water_cell
		C_cell: PBPK_model_human_Ab|Organism|Skin|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell: PBPK_model_human_Ab|Organism|Skin|Intracellular|CDA1|Partition coefficient (water/container)(1.51789558967143)

Observer: Tissue
	Path: PBPK_model_human_Ab|Organism|Skin|CDA1|Tissue
	Formula: (V_int*C_int+V_cell*C_cell+V_end*C_end)/(V_int+V_cell+V_end)
		V_end: PBPK_model_human_Ab|Organism|Skin|Endosome|Volume(0.000986644876998516 [l])
		V_int: PBPK_model_human_Ab|Organism|Skin|Interstitial|Volume(1.13641019394947 [l])
		V_cell: PBPK_model_human_Ab|Organism|Skin|Intracellular|Volume(2.45344187567899 [l])
		C_cell: PBPK_model_human_Ab|Organism|Skin|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1|Concentration(0 [µmol/l])

Observer: Whole Organ
	Path: PBPK_model_human_Ab|Organism|Skin|CDA1|Whole Organ
	Formula: (fBloodForSampling*(V_pls*C_pls + V_bc*C_bc) + V_end*C_end + V_int*C_int + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Skin|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Skin|BloodCells|Volume(0.0813549284542636 [l])
		V_end: PBPK_model_human_Ab|Organism|Skin|Endosome|Volume(0.000986644876998516 [l])
		V_int: PBPK_model_human_Ab|Organism|Skin|Interstitial|Volume(1.13641019394947 [l])
		V_cell: PBPK_model_human_Ab|Organism|Skin|Intracellular|Volume(2.45344187567899 [l])
		V_pls: PBPK_model_human_Ab|Organism|Skin|Plasma|Volume(0.0917406640016164 [l])
		C_bc: PBPK_model_human_Ab|Organism|Skin|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Skin|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Whole Organ incl. FcRn_Complex-CDA1
	Path: PBPK_model_human_Ab|Organism|Skin|CDA1|Whole Organ incl. FcRn_Complex-CDA1
	Formula: (fBloodForSampling*(V_pls*(C_pls+C_pls_Complex) + V_bc*C_bc) + V_end*(C_end+C_end_Complex) + V_int*(C_int+C_int_Complex) + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Skin|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Skin|BloodCells|Volume(0.0813549284542636 [l])
		V_end: PBPK_model_human_Ab|Organism|Skin|Endosome|Volume(0.000986644876998516 [l])
		V_int: PBPK_model_human_Ab|Organism|Skin|Interstitial|Volume(1.13641019394947 [l])
		V_cell: PBPK_model_human_Ab|Organism|Skin|Intracellular|Volume(2.45344187567899 [l])
		V_pls: PBPK_model_human_Ab|Organism|Skin|Plasma|Volume(0.0917406640016164 [l])
		C_end_Complex: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_int_Complex: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_pls_Complex: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_bc: PBPK_model_human_Ab|Organism|Skin|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Skin|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Skin|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Skin|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Skin|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Spleen|Plasma|Volume(0.0361911749257049 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Spleen|BloodCells|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Spleen|BloodCells|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Spleen|BloodCells|Volume(0.0320940607831723 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Spleen|Interstitial|Volume(0.0310387435040351 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Spleen|Intracellular|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Spleen|Intracellular|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Spleen|Intracellular|Volume(0.107600977480655 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Spleen|Endosome|Volume(0.0003892258435406 [l])

Observer: Interstitial Unbound
	Path: PBPK_model_human_Ab|Organism|Spleen|CDA1|Interstitial Unbound
	Formula: C_int * K_water_int
		C_int: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1|Concentration(0 [µmol/l])
		K_water_int: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1|Partition coefficient (water/container)(1.03909058791745)

Observer: Intracellular Unbound
	Path: PBPK_model_human_Ab|Organism|Spleen|CDA1|Intracellular Unbound
	Formula: C_cell * K_water_cell
		C_cell: PBPK_model_human_Ab|Organism|Spleen|Intracellular|CDA1|Concentration(0 [µmol/l])
		K_water_cell: PBPK_model_human_Ab|Organism|Spleen|Intracellular|CDA1|Partition coefficient (water/container)(1.23528605190271)

Observer: Tissue
	Path: PBPK_model_human_Ab|Organism|Spleen|CDA1|Tissue
	Formula: (V_int*C_int+V_cell*C_cell+V_end*C_end)/(V_int+V_cell+V_end)
		V_end: PBPK_model_human_Ab|Organism|Spleen|Endosome|Volume(0.0003892258435406 [l])
		V_int: PBPK_model_human_Ab|Organism|Spleen|Interstitial|Volume(0.0310387435040351 [l])
		V_cell: PBPK_model_human_Ab|Organism|Spleen|Intracellular|Volume(0.107600977480655 [l])
		C_cell: PBPK_model_human_Ab|Organism|Spleen|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1|Concentration(0 [µmol/l])

Observer: Whole Organ
	Path: PBPK_model_human_Ab|Organism|Spleen|CDA1|Whole Organ
	Formula: (fBloodForSampling*(V_pls*C_pls + V_bc*C_bc) + V_end*C_end + V_int*C_int + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Spleen|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Spleen|BloodCells|Volume(0.0320940607831723 [l])
		V_end: PBPK_model_human_Ab|Organism|Spleen|Endosome|Volume(0.0003892258435406 [l])
		V_int: PBPK_model_human_Ab|Organism|Spleen|Interstitial|Volume(0.0310387435040351 [l])
		V_cell: PBPK_model_human_Ab|Organism|Spleen|Intracellular|Volume(0.107600977480655 [l])
		V_pls: PBPK_model_human_Ab|Organism|Spleen|Plasma|Volume(0.0361911749257049 [l])
		C_bc: PBPK_model_human_Ab|Organism|Spleen|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Spleen|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Whole Organ incl. FcRn_Complex-CDA1
	Path: PBPK_model_human_Ab|Organism|Spleen|CDA1|Whole Organ incl. FcRn_Complex-CDA1
	Formula: (fBloodForSampling*(V_pls*(C_pls+C_pls_Complex) + V_bc*C_bc) + V_end*(C_end+C_end_Complex) + V_int*(C_int+C_int_Complex) + V_cell*C_cell)/(fBloodForSampling*(V_pls+V_bc) + V_end + V_int + V_cell)
		fBloodForSampling: PBPK_model_human_Ab|Organism|Spleen|Fraction of blood for sampling(1)
		V_bc: PBPK_model_human_Ab|Organism|Spleen|BloodCells|Volume(0.0320940607831723 [l])
		V_end: PBPK_model_human_Ab|Organism|Spleen|Endosome|Volume(0.0003892258435406 [l])
		V_int: PBPK_model_human_Ab|Organism|Spleen|Interstitial|Volume(0.0310387435040351 [l])
		V_cell: PBPK_model_human_Ab|Organism|Spleen|Intracellular|Volume(0.107600977480655 [l])
		V_pls: PBPK_model_human_Ab|Organism|Spleen|Plasma|Volume(0.0361911749257049 [l])
		C_end_Complex: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_int_Complex: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_pls_Complex: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1-FcRn_Complex|Concentration(0 [µmol/l])
		C_bc: PBPK_model_human_Ab|Organism|Spleen|BloodCells|CDA1|Concentration(0 [µmol/l])
		C_cell: PBPK_model_human_Ab|Organism|Spleen|Intracellular|CDA1|Concentration(0 [µmol/l])
		C_end: PBPK_model_human_Ab|Organism|Spleen|Endosome|CDA1|Concentration(0 [µmol/l])
		C_int: PBPK_model_human_Ab|Organism|Spleen|Interstitial|CDA1|Concentration(0 [µmol/l])
		C_pls: PBPK_model_human_Ab|Organism|Spleen|Plasma|CDA1|Concentration(0 [µmol/l])
		HCT: PBPK_model_human_Ab|Organism|Hematocrit(0.47)

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Saliva|Saliva|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Saliva|Saliva|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Saliva|Saliva|Volume(0.00600000000845946 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|Saliva|SalivaGland|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|Saliva|SalivaGland|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|Saliva|SalivaGland|Volume(0.00600000000845946 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Organism|EndosomalClearance|CDA1(0 [µmol])
		V: PBPK_model_human_Ab|Organism|EndosomalClearance|Volume(1 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|CDA1(0.584000000823388 [µmol])
		V: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|Volume(1 [l])

Observer: Concentration in container
	Path: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|CDA1|Concentration in container
	Formula: V>0 ? M/V : 0
		M: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|CDA1(9.14933334623307 [µmol])
		V: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|Volume(1 [l])

--------------- NEIGHBORHOODS ----------
Neighborhood: VenousBlood_pls_VenousBlood_bc
	1st neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells

Neighborhood: VenousBlood_pls_Lung_pls
	1st neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Lung|Plasma

Neighborhood: VenousBlood_bc_Lung_bc
	1st neighbor: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|Lung|BloodCells

Neighborhood: ArterialBlood_pls_ArterialBlood_bc
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells

Neighborhood: Bone_int_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Bone|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Bone_end_Bone_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|Bone|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Bone_pls_Bone_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Bone|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Bone|BloodCells

Neighborhood: Bone_int_Bone_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Bone|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|Bone|Intracellular

Neighborhood: Bone_pls_Bone_end
	1st neighbor: PBPK_model_human_Ab|Organism|Bone|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Bone|Endosome

Neighborhood: Bone_end_Bone_int
	1st neighbor: PBPK_model_human_Ab|Organism|Bone|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|Bone|Interstitial

Neighborhood: Bone_pls_Bone_int
	1st neighbor: PBPK_model_human_Ab|Organism|Bone|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Bone|Interstitial

Neighborhood: Bone_pls_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Bone|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Bone_bc_VenousBlood_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Bone|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells

Neighborhood: Brain_pls_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Brain|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Brain_end_Brain_int
	1st neighbor: PBPK_model_human_Ab|Organism|Brain|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|Brain|Interstitial

Neighborhood: Brain_pls_Brain_int
	1st neighbor: PBPK_model_human_Ab|Organism|Brain|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Brain|Interstitial

Neighborhood: Brain_pls_Brain_end
	1st neighbor: PBPK_model_human_Ab|Organism|Brain|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Brain|Endosome

Neighborhood: Brain_int_Brain_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Brain|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|Brain|Intracellular

Neighborhood: Brain_pls_Brain_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Brain|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Brain|BloodCells

Neighborhood: Brain_int_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Brain|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Brain_bc_VenousBlood_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Brain|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells

Neighborhood: Brain_end_Brain_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|Brain|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Fat_pls_Fat_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Fat|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Fat|BloodCells

Neighborhood: Fat_end_Fat_int
	1st neighbor: PBPK_model_human_Ab|Organism|Fat|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|Fat|Interstitial

Neighborhood: Fat_int_Fat_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Fat|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|Fat|Intracellular

Neighborhood: Fat_bc_VenousBlood_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Fat|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells

Neighborhood: Fat_end_Fat_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|Fat|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Fat_pls_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Fat|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Fat_pls_Fat_end
	1st neighbor: PBPK_model_human_Ab|Organism|Fat|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Fat|Endosome

Neighborhood: Fat_pls_Fat_int
	1st neighbor: PBPK_model_human_Ab|Organism|Fat|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Fat|Interstitial

Neighborhood: Fat_int_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Fat|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Gonads_pls_Gonads_int
	1st neighbor: PBPK_model_human_Ab|Organism|Gonads|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Gonads|Interstitial

Neighborhood: Gonads_pls_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Gonads|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Gonads_pls_Gonads_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Gonads|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Gonads|BloodCells

Neighborhood: Gonads_bc_VenousBlood_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Gonads|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells

Neighborhood: Gonads_end_Gonads_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|Gonads|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Gonads_end_Gonads_int
	1st neighbor: PBPK_model_human_Ab|Organism|Gonads|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|Gonads|Interstitial

Neighborhood: Gonads_pls_Gonads_end
	1st neighbor: PBPK_model_human_Ab|Organism|Gonads|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Gonads|Endosome

Neighborhood: Gonads_int_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Gonads|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Gonads_int_Gonads_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Gonads|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|Gonads|Intracellular

Neighborhood: Heart_int_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Heart|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Heart_pls_Heart_int
	1st neighbor: PBPK_model_human_Ab|Organism|Heart|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Heart|Interstitial

Neighborhood: Heart_pls_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Heart|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Heart_pls_Heart_end
	1st neighbor: PBPK_model_human_Ab|Organism|Heart|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Heart|Endosome

Neighborhood: Heart_pls_Heart_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Heart|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Heart|BloodCells

Neighborhood: Heart_int_Heart_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Heart|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|Heart|Intracellular

Neighborhood: Heart_end_Heart_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|Heart|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Heart_end_Heart_int
	1st neighbor: PBPK_model_human_Ab|Organism|Heart|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|Heart|Interstitial

Neighborhood: Heart_bc_VenousBlood_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Heart|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells

Neighborhood: Kidney_bc_VenousBlood_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Kidney|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells

Neighborhood: Lumen_uje_UpperJejunum_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular

Neighborhood: UpperJejunum_pls_PortalVein_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma

Neighborhood: UpperJejunum_bc_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: Kidney_int_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Kidney|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Kidney_cell_Kidney_ur
	1st neighbor: PBPK_model_human_Ab|Organism|Kidney|Intracellular
	2nd neighbor: PBPK_model_human_Ab|Organism|Kidney|Urine

Neighborhood: Kidney_pls_Kidney_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Kidney|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Kidney|BloodCells

Neighborhood: Kidney_pls_Kidney_end
	1st neighbor: PBPK_model_human_Ab|Organism|Kidney|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Kidney|Endosome

Neighborhood: Kidney_pls_Kidney_int
	1st neighbor: PBPK_model_human_Ab|Organism|Kidney|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Kidney|Interstitial

Neighborhood: Kidney_pls_Kidney_ur
	1st neighbor: PBPK_model_human_Ab|Organism|Kidney|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Kidney|Urine

Neighborhood: Kidney_pls_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Kidney|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Kidney_end_Kidney_int
	1st neighbor: PBPK_model_human_Ab|Organism|Kidney|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|Kidney|Interstitial

Neighborhood: Lumen_uje_UpperJejunum_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma

Neighborhood: Kidney_end_Kidney_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|Kidney|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Kidney_int_Kidney_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Kidney|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|Kidney|Intracellular

Neighborhood: Lumen_duo_Lumen_uje
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|Duodenum
	2nd neighbor: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum

Neighborhood: Lumen_lje_LowerJejunum_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma

Neighborhood: Lumen_uil_Lumen_lil
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|UpperIleum
	2nd neighbor: PBPK_model_human_Ab|Organism|Lumen|LowerIleum

Neighborhood: Lumen_cae_Lumen_colasc
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|Caecum
	2nd neighbor: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens

Neighborhood: Lumen_lje_Lumen_uil
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum
	2nd neighbor: PBPK_model_human_Ab|Organism|Lumen|UpperIleum

Neighborhood: Lumen_lil_Lumen_cae
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|LowerIleum
	2nd neighbor: PBPK_model_human_Ab|Organism|Lumen|Caecum

Neighborhood: Lumen_colasc_Lumen_coltrans
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens
	2nd neighbor: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum

Neighborhood: Lumen_coltrans_Lumen_coldesc
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum
	2nd neighbor: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens

Neighborhood: Lumen_colsigm_Lumen_rect
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid
	2nd neighbor: PBPK_model_human_Ab|Organism|Lumen|Rectum

Neighborhood: Lumen_rect_Lumen_fec
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|Rectum
	2nd neighbor: PBPK_model_human_Ab|Organism|Lumen|Feces

Neighborhood: Lumen_coldesc_Lumen_colsigm
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens
	2nd neighbor: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid

Neighborhood: Lumen_uje_Lumen_lje
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum
	2nd neighbor: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum

Neighborhood: LowerJejunum_pls_PortalVein_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma

Neighborhood: Lumen_lje_LowerJejunum_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular

Neighborhood: Lumen_sto_Lumen_duo
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|Stomach
	2nd neighbor: PBPK_model_human_Ab|Organism|Lumen|Duodenum

Neighborhood: LowerJejunum_bc_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: UpperIleum_bc_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: Stomach_pls_Stomach_int
	1st neighbor: PBPK_model_human_Ab|Organism|Stomach|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Stomach|Interstitial

Neighborhood: Stomach_pls_PortalVein_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Stomach|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma

Neighborhood: Stomach_bc_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Stomach|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: Stomach_end_Stomach_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|Stomach|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Stomach_end_Stomach_int
	1st neighbor: PBPK_model_human_Ab|Organism|Stomach|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|Stomach|Interstitial

Neighborhood: Stomach_int_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Stomach|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Stomach_pls_Stomach_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Stomach|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Stomach|BloodCells

Neighborhood: Stomach_pls_Stomach_end
	1st neighbor: PBPK_model_human_Ab|Organism|Stomach|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Stomach|Endosome

Neighborhood: Stomach_int_Stomach_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Stomach|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|Stomach|Intracellular

Neighborhood: Lumen_uil_UpperIleum_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|UpperIleum
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular

Neighborhood: Lumen_uil_UpperIleum_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|UpperIleum
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma

Neighborhood: UpperIleum_pls_PortalVein_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma

Neighborhood: SmallIntestine_end_SmallIntestine_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: SmallIntestine_bc_LowerJejunum_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells

Neighborhood: SmallIntestine_pls_LowerJejunum_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma

Neighborhood: Lumen_lil_LowerIleum_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|LowerIleum
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma

Neighborhood: SmallIntestine_pls_PortalVein_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma

Neighborhood: Lumen_lil_LowerIleum_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|LowerIleum
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular

Neighborhood: SmallIntestine_pls_SmallIntestine_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells

Neighborhood: SmallIntestine_bc_UpperIleum_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells

Neighborhood: SmallIntestine_pls_SmallIntestine_end
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome

Neighborhood: SmallIntestine_pls_UpperIleum_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma

Neighborhood: SmallIntestine_pls_SmallIntestine_int
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial

Neighborhood: LowerIleum_bc_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: LowerIleum_pls_PortalVein_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma

Neighborhood: SmallIntestine_bc_LowerIleum_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells

Neighborhood: SmallIntestine_pls_LowerIleum_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma

Neighborhood: SmallIntestine_bc_Duodenum_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells

Neighborhood: SmallIntestine_int_SmallIntestine_cell
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular

Neighborhood: SmallIntestine_end_SmallIntestine_int
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial

Neighborhood: SmallIntestine_pls_UpperJejunum_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma

Neighborhood: SmallIntestine_pls_Duodenum_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma

Neighborhood: SmallIntestine_int_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: SmallIntestine_bc_UpperJejunum_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells

Neighborhood: SmallIntestine_bc_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: LargeIntestine_end_LargeIntestine_int
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial

Neighborhood: LargeIntestine_end_LargeIntestine_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: LargeIntestine_int_LargeIntestine_cell
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular

Neighborhood: LargeIntestine_bc_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: LargeIntestine_pls_PortalVein_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma

Neighborhood: LargeIntestine_pls_LargeIntestine_end
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome

Neighborhood: LargeIntestine_int_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: LargeIntestine_pls_LargeIntestine_int
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial

Neighborhood: LargeIntestine_pls_LargeIntestine_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells

Neighborhood: LargeIntestine_pls_ColonDescendens_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma

Neighborhood: LargeIntestine_pls_ColonTransversum_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma

Neighborhood: LargeIntestine_pls_ColonAscendens_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma

Neighborhood: LargeIntestine_bc_Caecum_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells

Neighborhood: LargeIntestine_bc_ColonDescendens_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells

Neighborhood: LargeIntestine_bc_ColonTransversum_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells

Neighborhood: LargeIntestine_bc_ColonAscendens_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells

Neighborhood: LargeIntestine_pls_ColonSigmoid_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma

Neighborhood: LargeIntestine_pls_Caecum_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma

Neighborhood: LargeIntestine_bc_Rectum_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells

Neighborhood: LargeIntestine_pls_Rectum_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma

Neighborhood: LargeIntestine_bc_ColonSigmoid_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells

Neighborhood: Liver_pls_Liver_int
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Interstitial

Neighborhood: Liver_pls_Liver_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|BloodCells

Neighborhood: Liver_int_Liver_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Intracellular

Neighborhood: Liver_end_Liver_int
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Interstitial

Neighborhood: Liver_pls_Liver_end
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Endosome

Neighborhood: Gallbladder_Lumen_duo
	1st neighbor: PBPK_model_human_Ab|Organism|Gallbladder
	2nd neighbor: PBPK_model_human_Ab|Organism|Lumen|Duodenum

Neighborhood: Periportal_pls_Periportal_int
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial

Neighborhood: Periportal_pls_Periportal_end
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome

Neighborhood: Periportal_pls_Periportal_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells

Neighborhood: Periportal_int_Periportal_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular

Neighborhood: Periportal_end_Periportal_int
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial

Neighborhood: Pericentral_pls_Pericentral_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells

Neighborhood: Pericentral_pls_Pericentral_end
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome

Neighborhood: Pericentral_int_Pericentral_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular

Neighborhood: Pericentral_end_Pericentral_int
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial

Neighborhood: Pericentral_pls_Pericentral_int
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial

Neighborhood: Lung_end_Lung_int
	1st neighbor: PBPK_model_human_Ab|Organism|Lung|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|Lung|Interstitial

Neighborhood: Lung_int_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Lung|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Lung_pls_ArterialBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Lung|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma

Neighborhood: Lung_pls_Lung_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Lung|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Lung|BloodCells

Neighborhood: Lung_int_Lung_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Lung|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|Lung|Intracellular

Neighborhood: Lung_pls_Lung_int
	1st neighbor: PBPK_model_human_Ab|Organism|Lung|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Lung|Interstitial

Neighborhood: Lung_bc_ArterialBlood_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Lung|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells

Neighborhood: Lung_end_Lung_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|Lung|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Lung_pls_Lung_end
	1st neighbor: PBPK_model_human_Ab|Organism|Lung|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Lung|Endosome

Neighborhood: Muscle_end_Muscle_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|Muscle|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Muscle_int_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Muscle|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Muscle_int_Muscle_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Muscle|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|Muscle|Intracellular

Neighborhood: Muscle_end_Muscle_int
	1st neighbor: PBPK_model_human_Ab|Organism|Muscle|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|Muscle|Interstitial

Neighborhood: Muscle_bc_VenousBlood_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Muscle|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells

Neighborhood: Muscle_pls_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Muscle|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Muscle_pls_Muscle_int
	1st neighbor: PBPK_model_human_Ab|Organism|Muscle|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Muscle|Interstitial

Neighborhood: Muscle_pls_Muscle_end
	1st neighbor: PBPK_model_human_Ab|Organism|Muscle|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Muscle|Endosome

Neighborhood: Muscle_pls_Muscle_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Muscle|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Muscle|BloodCells

Neighborhood: Pancreas_pls_Pancreas_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Pancreas|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Pancreas|BloodCells

Neighborhood: Pancreas_pls_Pancreas_end
	1st neighbor: PBPK_model_human_Ab|Organism|Pancreas|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Pancreas|Endosome

Neighborhood: Pancreas_pls_Pancreas_int
	1st neighbor: PBPK_model_human_Ab|Organism|Pancreas|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Pancreas|Interstitial

Neighborhood: Pancreas_int_Pancreas_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Pancreas|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|Pancreas|Intracellular

Neighborhood: Pancreas_end_Pancreas_int
	1st neighbor: PBPK_model_human_Ab|Organism|Pancreas|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|Pancreas|Interstitial

Neighborhood: Pancreas_end_Pancreas_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|Pancreas|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Pancreas_int_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Pancreas|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Pancreas_pls_PortalVein_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Pancreas|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma

Neighborhood: Pancreas_bc_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Pancreas|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: Rectum_pls_PortalVein_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma

Neighborhood: Rectum_bc_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: Lumen_rect_Rectum_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|Rectum
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular

Neighborhood: Lumen_rect_Rectum_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|Rectum
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma

Neighborhood: PortalVein_pls_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: Skin_pls_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Skin|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Skin_end_Skin_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|Skin|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Skin_pls_Skin_end
	1st neighbor: PBPK_model_human_Ab|Organism|Skin|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Skin|Endosome

Neighborhood: Skin_pls_Skin_int
	1st neighbor: PBPK_model_human_Ab|Organism|Skin|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Skin|Interstitial

Neighborhood: Skin_int_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Skin|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Skin_bc_VenousBlood_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Skin|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells

Neighborhood: Skin_end_Skin_int
	1st neighbor: PBPK_model_human_Ab|Organism|Skin|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|Skin|Interstitial

Neighborhood: Skin_int_Skin_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Skin|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|Skin|Intracellular

Neighborhood: Skin_pls_Skin_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Skin|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Skin|BloodCells

Neighborhood: Spleen_end_Spleen_int
	1st neighbor: PBPK_model_human_Ab|Organism|Spleen|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|Spleen|Interstitial

Neighborhood: Spleen_bc_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Spleen|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: Spleen_end_Spleen_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|Spleen|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Spleen_int_Spleen_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Spleen|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|Spleen|Intracellular

Neighborhood: Spleen_int_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Spleen|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Spleen_pls_PortalVein_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Spleen|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma

Neighborhood: Spleen_pls_Spleen_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Spleen|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Spleen|BloodCells

Neighborhood: Spleen_pls_Spleen_end
	1st neighbor: PBPK_model_human_Ab|Organism|Spleen|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Spleen|Endosome

Neighborhood: Spleen_pls_Spleen_int
	1st neighbor: PBPK_model_human_Ab|Organism|Spleen|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Spleen|Interstitial

Neighborhood: EndogenousIgG_pls_EndogenousIgG_iggend
	1st neighbor: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome

Neighborhood: EndogenousIgG_iggend_EndogenousIgG_int
	1st neighbor: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial

Neighborhood: EndogenousIgG_iggsrc_EndogenousIgG_pls
	1st neighbor: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_Source
	2nd neighbor: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma

Neighborhood: EndogenousIgG_int_EndogenousIgG_pls
	1st neighbor: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma

Neighborhood: EndogenousIgG_iggend_EndogenousIgG_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndogenousIgG|EndosomalClearance

Neighborhood: Saliva_slv_Saliva_slv
	1st neighbor: PBPK_model_human_Ab|Organism|Saliva|SalivaGland
	2nd neighbor: PBPK_model_human_Ab|Organism|Saliva|Saliva

Neighborhood: Duodenum_end_Duodenum_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Duodenum_end_Duodenum_int
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial

Neighborhood: Duodenum_int_Duodenum_cell
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular

Neighborhood: Duodenum_pls_Duodenum_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells

Neighborhood: Duodenum_pls_Duodenum_end
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome

Neighborhood: Duodenum_pls_Duodenum_int
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial

Neighborhood: UpperJejunum_end_UpperJejunum_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: UpperJejunum_pls_UpperJejunum_int
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial

Neighborhood: UpperJejunum_pls_UpperJejunum_end
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome

Neighborhood: UpperJejunum_pls_UpperJejunum_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells

Neighborhood: UpperJejunum_int_UpperJejunum_cell
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular

Neighborhood: UpperJejunum_end_UpperJejunum_int
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial

Neighborhood: LowerJejunum_pls_LowerJejunum_end
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome

Neighborhood: LowerJejunum_pls_LowerJejunum_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells

Neighborhood: LowerJejunum_int_LowerJejunum_cell
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular

Neighborhood: LowerJejunum_end_LowerJejunum_int
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial

Neighborhood: LowerJejunum_pls_LowerJejunum_int
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial

Neighborhood: LowerJejunum_end_LowerJejunum_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: UpperIleum_end_UpperIleum_int
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial

Neighborhood: UpperIleum_int_UpperIleum_cell
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular

Neighborhood: UpperIleum_pls_UpperIleum_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells

Neighborhood: UpperIleum_end_UpperIleum_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: UpperIleum_pls_UpperIleum_end
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome

Neighborhood: UpperIleum_pls_UpperIleum_int
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial

Neighborhood: LowerIleum_pls_LowerIleum_end
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome

Neighborhood: LowerIleum_pls_LowerIleum_int
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial

Neighborhood: LowerIleum_end_LowerIleum_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: LowerIleum_int_LowerIleum_cell
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular

Neighborhood: LowerIleum_end_LowerIleum_int
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial

Neighborhood: LowerIleum_pls_LowerIleum_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells

Neighborhood: Caecum_end_Caecum_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Caecum_pls_Caecum_int
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial

Neighborhood: Caecum_end_Caecum_int
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial

Neighborhood: Caecum_int_Caecum_cell
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular

Neighborhood: Caecum_pls_Caecum_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells

Neighborhood: Caecum_pls_Caecum_end
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome

Neighborhood: ColonAscendens_pls_ColonAscendens_end
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome

Neighborhood: ColonAscendens_end_ColonAscendens_int
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial

Neighborhood: ColonAscendens_pls_ColonAscendens_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells

Neighborhood: ColonAscendens_int_ColonAscendens_cell
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular

Neighborhood: ColonAscendens_end_ColonAscendens_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: ColonAscendens_pls_ColonAscendens_int
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial

Neighborhood: ColonTransversum_pls_ColonTransversum_end
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome

Neighborhood: ColonTransversum_pls_ColonTransversum_int
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial

Neighborhood: ColonTransversum_pls_ColonTransversum_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells

Neighborhood: ColonTransversum_int_ColonTransversum_cell
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular

Neighborhood: ColonTransversum_end_ColonTransversum_int
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial

Neighborhood: ColonTransversum_end_ColonTransversum_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: ColonDescendens_int_ColonDescendens_cell
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular

Neighborhood: ColonDescendens_pls_ColonDescendens_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells

Neighborhood: ColonDescendens_pls_ColonDescendens_end
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome

Neighborhood: ColonDescendens_pls_ColonDescendens_int
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial

Neighborhood: ColonDescendens_end_ColonDescendens_int
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial

Neighborhood: ColonDescendens_end_ColonDescendens_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: ColonSigmoid_pls_ColonSigmoid_end
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome

Neighborhood: ColonSigmoid_int_ColonSigmoid_cell
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular

Neighborhood: ColonSigmoid_end_ColonSigmoid_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: ColonSigmoid_pls_ColonSigmoid_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells

Neighborhood: ColonSigmoid_end_ColonSigmoid_int
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial

Neighborhood: ColonSigmoid_pls_ColonSigmoid_int
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial

Neighborhood: Rectum_int_Rectum_cell
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular

Neighborhood: Rectum_pls_Rectum_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells

Neighborhood: Rectum_pls_Rectum_int
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial

Neighborhood: Rectum_pls_Rectum_end
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome

Neighborhood: Rectum_end_Rectum_int
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial

Neighborhood: Rectum_end_Rectum_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Duodenum_pls_PortalVein_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma

Neighborhood: Duodenum_bc_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: Lumen_duo_Duodenum_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|Duodenum
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular

Neighborhood: Lumen_duo_Duodenum_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|Duodenum
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma

Neighborhood: Lumen_cae_Caecum_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|Caecum
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma

Neighborhood: ArterialBlood_bc_Bone_bc
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|Bone|BloodCells

Neighborhood: ArterialBlood_pls_LargeIntestine_pls
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma

Neighborhood: ArterialBlood_bc_SmallIntestine_bc
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells

Neighborhood: ArterialBlood_bc_Spleen_bc
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|Spleen|BloodCells

Neighborhood: ArterialBlood_bc_Stomach_bc
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|Stomach|BloodCells

Neighborhood: ArterialBlood_pls_Bone_pls
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Bone|Plasma

Neighborhood: ArterialBlood_pls_Brain_pls
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Brain|Plasma

Neighborhood: ArterialBlood_pls_Fat_pls
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Fat|Plasma

Neighborhood: ArterialBlood_pls_Gonads_pls
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Gonads|Plasma

Neighborhood: ArterialBlood_pls_Kidney_pls
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Kidney|Plasma

Neighborhood: ArterialBlood_pls_Muscle_pls
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Muscle|Plasma

Neighborhood: ArterialBlood_pls_Pancreas_pls
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Pancreas|Plasma

Neighborhood: ArterialBlood_pls_Skin_pls
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Skin|Plasma

Neighborhood: ArterialBlood_pls_SmallIntestine_pls
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma

Neighborhood: ArterialBlood_pls_Spleen_pls
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Spleen|Plasma

Neighborhood: ArterialBlood_pls_Stomach_pls
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Stomach|Plasma

Neighborhood: ArterialBlood_pls_Heart_pls
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Heart|Plasma

Neighborhood: ArterialBlood_bc_Skin_bc
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|Skin|BloodCells

Neighborhood: ArterialBlood_bc_Brain_bc
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|Brain|BloodCells

Neighborhood: ArterialBlood_bc_Fat_bc
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|Fat|BloodCells

Neighborhood: ArterialBlood_bc_Gonads_bc
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|Gonads|BloodCells

Neighborhood: ArterialBlood_bc_Heart_bc
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|Heart|BloodCells

Neighborhood: ArterialBlood_bc_Kidney_bc
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|Kidney|BloodCells

Neighborhood: ArterialBlood_bc_LargeIntestine_bc
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells

Neighborhood: ArterialBlood_bc_Pancreas_bc
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|Pancreas|BloodCells

Neighborhood: ArterialBlood_bc_Muscle_bc
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|Muscle|BloodCells

Neighborhood: Lumen_coltrans_ColonTransversum_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma

Neighborhood: Lumen_colsigm_ColonSigmoid_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma

Neighborhood: ColonDescendens_bc_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: ColonDescendens_pls_PortalVein_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma

Neighborhood: Lumen_coldesc_ColonDescendens_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular

Neighborhood: Lumen_coldesc_ColonDescendens_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma

Neighborhood: ColonTransversum_bc_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: ColonSigmoid_pls_PortalVein_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma

Neighborhood: Lumen_coltrans_ColonTransversum_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular

Neighborhood: ColonSigmoid_bc_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: ColonAscendens_bc_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: ColonAscendens_pls_PortalVein_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma

Neighborhood: Lumen_colasc_ColonAscendens_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular

Neighborhood: Lumen_colasc_ColonAscendens_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma

Neighborhood: Caecum_bc_PortalVein_bc
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells

Neighborhood: Caecum_pls_PortalVein_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma

Neighborhood: Lumen_cae_Caecum_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|Caecum
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular

Neighborhood: ColonTransversum_pls_PortalVein_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma

Neighborhood: Lumen_colsigm_ColonSigmoid_cell
	1st neighbor: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid
	2nd neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular

Neighborhood: ColonDescendens_cell__VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: ColonTransversum_cell__VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: ColonAscendens_cell__VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Caecum_cell__VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: LowerIleum_cell__VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: UpperIleum_cell__VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: UpperJejunum_cell__VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: LowerJejunum_cell__VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: ColonSigmoid_cell__VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Rectum_cell__VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Duodenum_cell__VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Periportal_int_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Pericentral_cell_Gallbladder
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular
	2nd neighbor: PBPK_model_human_Ab|Organism|Gallbladder

Neighborhood: Periportal_cell_Gallbladder
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular
	2nd neighbor: PBPK_model_human_Ab|Organism|Gallbladder

Neighborhood: Pericentral_pls_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Periportal_pls_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Pericentral_cell_Lumen_duo
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular
	2nd neighbor: PBPK_model_human_Ab|Organism|Lumen|Duodenum

Neighborhood: Periportal_end_Organism_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Pericentral_end_Organism_ecl
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome
	2nd neighbor: PBPK_model_human_Ab|Organism|EndosomalClearance

Neighborhood: Periportal_cell_Lumen_duo
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular
	2nd neighbor: PBPK_model_human_Ab|Organism|Lumen|Duodenum

Neighborhood: Periportal_bc_Pericentral_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells

Neighborhood: Pericentral_int_VenousBlood_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|Plasma

Neighborhood: Periportal_pls_Pericentral_pls
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma

Neighborhood: ArterialBlood_bc_Periportal_bc
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells

Neighborhood: ArterialBlood_pls_Periportal_pls
	1st neighbor: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma

Neighborhood: PortalVein_bc_Periportal_bc
	1st neighbor: PBPK_model_human_Ab|Organism|PortalVein|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells

Neighborhood: PortalVein_pls_Periportal_pls
	1st neighbor: PBPK_model_human_Ab|Organism|PortalVein|Plasma
	2nd neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma

Neighborhood: Pericentral_bc_VenousBlood_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells

Neighborhood: Periportal_bc_VenousBlood_bc
	1st neighbor: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells
	2nd neighbor: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells

--------------- CONTAINERS ----------
Container: PBPK_model_human_Ab|Organism
	Type: Organism
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Events
	Type: Other
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods
	Type: Other
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|LigandEndo
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|FcRn
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|LigandEndo_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|FcRn kinetics plasma
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|FcRn kinetics interstitial
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|FcRn kinetics endosome
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|FcRn binding CDA1 in endosomal space
	Type: Reaction
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|FcRn binding CDA1 in interstitial
	Type: Reaction
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|FcRn binding CDA1 in plasma
	Type: Reaction
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|FcRn binding endogenous Igg
	Type: Reaction
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|FcRn binding tissue CDA1
	Type: Reaction
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Applications
	Type: EventGroup
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|PeripheralVenousBlood
	Type: Organ
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|VenousBlood
	Type: Organ
	Mode: Logical
	Tags: BloodOrgan

Container: PBPK_model_human_Ab|Organism|ArterialBlood
	Type: Organ
	Mode: Logical
	Tags: BloodOrgan

Container: PBPK_model_human_Ab|Organism|Bone
	Type: Organ
	Mode: Logical
	Tags: TissueOrgan

Container: PBPK_model_human_Ab|Organism|Gallbladder
	Type: Organ
	Mode: Physical
	Tags: Liver

Container: PBPK_model_human_Ab|Organism|Brain
	Type: Organ
	Mode: Logical
	Tags: TissueOrgan

Container: PBPK_model_human_Ab|Organism|Fat
	Type: Organ
	Mode: Logical
	Tags: TissueOrgan

Container: PBPK_model_human_Ab|Organism|Gonads
	Type: Organ
	Mode: Logical
	Tags: TissueOrgan

Container: PBPK_model_human_Ab|Organism|Heart
	Type: Organ
	Mode: Logical
	Tags: TissueOrgan

Container: PBPK_model_human_Ab|Organism|Kidney
	Type: Organ
	Mode: Logical
	Tags: TissueOrgan

Container: PBPK_model_human_Ab|Organism|Lumen
	Type: Organ
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Stomach
	Type: Organ
	Mode: Logical
	Tags: Portal Vein Supplying Organ|TissueOrgan

Container: PBPK_model_human_Ab|Organism|SmallIntestine
	Type: Organ
	Mode: Logical
	Tags: Portal Vein Supplying Organ|TissueOrgan

Container: PBPK_model_human_Ab|Organism|LargeIntestine
	Type: Organ
	Mode: Logical
	Tags: Portal Vein Supplying Organ|TissueOrgan

Container: PBPK_model_human_Ab|Organism|Liver
	Type: Organ
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Lung
	Type: Organ
	Mode: Logical
	Tags: TissueOrgan

Container: PBPK_model_human_Ab|Organism|Muscle
	Type: Organ
	Mode: Logical
	Tags: TissueOrgan

Container: PBPK_model_human_Ab|Organism|Pancreas
	Type: Organ
	Mode: Logical
	Tags: Portal Vein Supplying Organ|TissueOrgan

Container: PBPK_model_human_Ab|Organism|PortalVein
	Type: Organ
	Mode: Logical
	Tags: BloodOrgan

Container: PBPK_model_human_Ab|Organism|Skin
	Type: Organ
	Mode: Logical
	Tags: TissueOrgan

Container: PBPK_model_human_Ab|Organism|Spleen
	Type: Organ
	Mode: Logical
	Tags: Portal Vein Supplying Organ|TissueOrgan

Container: PBPK_model_human_Ab|Organism|EndogenousIgG
	Type: Organ
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Saliva
	Type: Organ
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|EndosomalClearance
	Type: Compartment
	Mode: Physical
	Tags: 

Container: PBPK_model_human_Ab|Organism|PeripheralVenousBlood|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|VenousBlood|Plasma
	Type: Compartment
	Mode: Physical
	Tags: BloodOrgan|VenousBlood

Container: PBPK_model_human_Ab|Organism|VenousBlood|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: BloodOrgan|VenousBlood

Container: PBPK_model_human_Ab|Organism|VenousBlood|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|ArterialBlood|Plasma
	Type: Compartment
	Mode: Physical
	Tags: ArterialBlood|BloodOrgan

Container: PBPK_model_human_Ab|Organism|ArterialBlood|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: ArterialBlood|BloodOrgan

Container: PBPK_model_human_Ab|Organism|ArterialBlood|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Bone|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Bone

Container: PBPK_model_human_Ab|Organism|Bone|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Bone

Container: PBPK_model_human_Ab|Organism|Bone|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Bone

Container: PBPK_model_human_Ab|Organism|Bone|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Bone

Container: PBPK_model_human_Ab|Organism|Bone|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Bone

Container: PBPK_model_human_Ab|Organism|Bone|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Brain|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Brain

Container: PBPK_model_human_Ab|Organism|Brain|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Brain

Container: PBPK_model_human_Ab|Organism|Brain|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Brain

Container: PBPK_model_human_Ab|Organism|Brain|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Brain

Container: PBPK_model_human_Ab|Organism|Brain|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Brain

Container: PBPK_model_human_Ab|Organism|Brain|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Fat|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Fat

Container: PBPK_model_human_Ab|Organism|Fat|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Fat

Container: PBPK_model_human_Ab|Organism|Fat|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Fat

Container: PBPK_model_human_Ab|Organism|Fat|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Fat

Container: PBPK_model_human_Ab|Organism|Fat|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Fat

Container: PBPK_model_human_Ab|Organism|Fat|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Gonads|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Gonads

Container: PBPK_model_human_Ab|Organism|Gonads|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Gonads

Container: PBPK_model_human_Ab|Organism|Gonads|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Gonads

Container: PBPK_model_human_Ab|Organism|Gonads|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Gonads

Container: PBPK_model_human_Ab|Organism|Gonads|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Gonads

Container: PBPK_model_human_Ab|Organism|Gonads|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Heart|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Heart

Container: PBPK_model_human_Ab|Organism|Heart|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Heart

Container: PBPK_model_human_Ab|Organism|Heart|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Heart

Container: PBPK_model_human_Ab|Organism|Heart|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Heart

Container: PBPK_model_human_Ab|Organism|Heart|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Heart

Container: PBPK_model_human_Ab|Organism|Heart|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Kidney|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Kidney

Container: PBPK_model_human_Ab|Organism|Kidney|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Kidney

Container: PBPK_model_human_Ab|Organism|Kidney|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Kidney

Container: PBPK_model_human_Ab|Organism|Kidney|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Kidney

Container: PBPK_model_human_Ab|Organism|Kidney|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Kidney

Container: PBPK_model_human_Ab|Organism|Kidney|Urine
	Type: Compartment
	Mode: Physical
	Tags: Kidney

Container: PBPK_model_human_Ab|Organism|Kidney|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Lumen|Stomach
	Type: Compartment
	Mode: Physical
	Tags: Lumen|LumenSegment

Container: PBPK_model_human_Ab|Organism|Lumen|Duodenum
	Type: Compartment
	Mode: Physical
	Tags: Lumen|LumenSegment

Container: PBPK_model_human_Ab|Organism|Lumen|UpperJejunum
	Type: Compartment
	Mode: Physical
	Tags: Lumen|LumenSegment

Container: PBPK_model_human_Ab|Organism|Lumen|LowerJejunum
	Type: Compartment
	Mode: Physical
	Tags: Lumen|LumenSegment

Container: PBPK_model_human_Ab|Organism|Lumen|UpperIleum
	Type: Compartment
	Mode: Physical
	Tags: Lumen|LumenSegment

Container: PBPK_model_human_Ab|Organism|Lumen|LowerIleum
	Type: Compartment
	Mode: Physical
	Tags: Lumen|LumenSegment

Container: PBPK_model_human_Ab|Organism|Lumen|Caecum
	Type: Compartment
	Mode: Physical
	Tags: Lumen|LumenSegment

Container: PBPK_model_human_Ab|Organism|Lumen|ColonAscendens
	Type: Compartment
	Mode: Physical
	Tags: Lumen|LumenSegment

Container: PBPK_model_human_Ab|Organism|Lumen|ColonTransversum
	Type: Compartment
	Mode: Physical
	Tags: Lumen|LumenSegment

Container: PBPK_model_human_Ab|Organism|Lumen|ColonDescendens
	Type: Compartment
	Mode: Physical
	Tags: Lumen|LumenSegment

Container: PBPK_model_human_Ab|Organism|Lumen|ColonSigmoid
	Type: Compartment
	Mode: Physical
	Tags: Lumen|LumenSegment

Container: PBPK_model_human_Ab|Organism|Lumen|Rectum
	Type: Compartment
	Mode: Physical
	Tags: Lumen|LumenSegment

Container: PBPK_model_human_Ab|Organism|Lumen|Feces
	Type: Compartment
	Mode: Physical
	Tags: Lumen|LumenSegment

Container: PBPK_model_human_Ab|Organism|Lumen|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Stomach|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Portal Vein Supplying Organ|Stomach

Container: PBPK_model_human_Ab|Organism|Stomach|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Portal Vein Supplying Organ|Stomach

Container: PBPK_model_human_Ab|Organism|Stomach|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Portal Vein Supplying Organ|Stomach

Container: PBPK_model_human_Ab|Organism|Stomach|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Portal Vein Supplying Organ|Stomach

Container: PBPK_model_human_Ab|Organism|Stomach|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Portal Vein Supplying Organ|Stomach

Container: PBPK_model_human_Ab|Organism|Stomach|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Portal Vein Supplying Organ|SmallIntestine

Container: PBPK_model_human_Ab|Organism|SmallIntestine|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Portal Vein Supplying Organ|SmallIntestine

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Portal Vein Supplying Organ|SmallIntestine

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Portal Vein Supplying Organ|SmallIntestine

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Portal Vein Supplying Organ|SmallIntestine

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa
	Type: Compartment
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|SmallIntestine|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum
	Type: Compartment
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum
	Type: Compartment
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum
	Type: Compartment
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum
	Type: Compartment
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum
	Type: Compartment
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Duodenum|Mucosa|SmallIntestineSegment

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Duodenum|Mucosa|SmallIntestineSegment

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Duodenum|Mucosa|SmallIntestineSegment

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Duodenum|IntestinalSecretionSource|Mucosa|SmallIntestineSegment

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|Duodenum|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Duodenum|Mucosa|SmallIntestineSegment

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Mucosa|SmallIntestineSegment|UpperJejunum

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Mucosa|SmallIntestineSegment|UpperJejunum

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Mucosa|SmallIntestineSegment|UpperJejunum

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: IntestinalSecretionSource|Mucosa|SmallIntestineSegment|UpperJejunum

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperJejunum|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Mucosa|SmallIntestineSegment|UpperJejunum

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Plasma
	Type: Compartment
	Mode: Physical
	Tags: LowerJejunum|Mucosa|SmallIntestineSegment

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: LowerJejunum|Mucosa|SmallIntestineSegment

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: LowerJejunum|Mucosa|SmallIntestineSegment

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: IntestinalSecretionSource|LowerJejunum|Mucosa|SmallIntestineSegment

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerJejunum|Endosome
	Type: Compartment
	Mode: Physical
	Tags: LowerJejunum|Mucosa|SmallIntestineSegment

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Mucosa|SmallIntestineSegment|UpperIleum

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Mucosa|SmallIntestineSegment|UpperIleum

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Mucosa|SmallIntestineSegment|UpperIleum

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: IntestinalSecretionSource|Mucosa|SmallIntestineSegment|UpperIleum

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|UpperIleum|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Mucosa|SmallIntestineSegment|UpperIleum

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Plasma
	Type: Compartment
	Mode: Physical
	Tags: LowerIleum|Mucosa|SmallIntestineSegment

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: LowerIleum|Mucosa|SmallIntestineSegment

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: LowerIleum|Mucosa|SmallIntestineSegment

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: IntestinalSecretionSource|LowerIleum|Mucosa|SmallIntestineSegment

Container: PBPK_model_human_Ab|Organism|SmallIntestine|Mucosa|LowerIleum|Endosome
	Type: Compartment
	Mode: Physical
	Tags: LowerIleum|Mucosa|SmallIntestineSegment

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Plasma
	Type: Compartment
	Mode: Physical
	Tags: LargeIntestine|Portal Vein Supplying Organ

Container: PBPK_model_human_Ab|Organism|LargeIntestine|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: LargeIntestine|Portal Vein Supplying Organ

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: LargeIntestine|Portal Vein Supplying Organ

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: LargeIntestine|Portal Vein Supplying Organ

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Endosome
	Type: Compartment
	Mode: Physical
	Tags: LargeIntestine|Portal Vein Supplying Organ

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa
	Type: Compartment
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|LargeIntestine|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum
	Type: Compartment
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens
	Type: Compartment
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum
	Type: Compartment
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens
	Type: Compartment
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid
	Type: Compartment
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum
	Type: Compartment
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Caecum|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Caecum|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Caecum|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Caecum|IntestinalSecretionSource|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Caecum|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Caecum|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Plasma
	Type: Compartment
	Mode: Physical
	Tags: ColonAscendens|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: ColonAscendens|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: ColonAscendens|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: ColonAscendens|IntestinalSecretionSource|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonAscendens|Endosome
	Type: Compartment
	Mode: Physical
	Tags: ColonAscendens|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Plasma
	Type: Compartment
	Mode: Physical
	Tags: ColonTransversum|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: ColonTransversum|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: ColonTransversum|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: ColonTransversum|IntestinalSecretionSource|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonTransversum|Endosome
	Type: Compartment
	Mode: Physical
	Tags: ColonTransversum|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Plasma
	Type: Compartment
	Mode: Physical
	Tags: ColonDescendens|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: ColonDescendens|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: ColonDescendens|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: ColonDescendens|IntestinalSecretionSource|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonDescendens|Endosome
	Type: Compartment
	Mode: Physical
	Tags: ColonDescendens|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Plasma
	Type: Compartment
	Mode: Physical
	Tags: ColonSigmoid|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: ColonSigmoid|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: ColonSigmoid|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: ColonSigmoid|IntestinalSecretionSource|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|ColonSigmoid|Endosome
	Type: Compartment
	Mode: Physical
	Tags: ColonSigmoid|LargeIntestineSegment|Mucosa

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Plasma
	Type: Compartment
	Mode: Physical
	Tags: LargeIntestineSegment|Mucosa|Rectum

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: LargeIntestineSegment|Mucosa|Rectum

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: LargeIntestineSegment|Mucosa|Rectum

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: IntestinalSecretionSource|LargeIntestineSegment|Mucosa|Rectum

Container: PBPK_model_human_Ab|Organism|LargeIntestine|Mucosa|Rectum|Endosome
	Type: Compartment
	Mode: Physical
	Tags: LargeIntestineSegment|Mucosa|Rectum

Container: PBPK_model_human_Ab|Organism|Liver|Periportal
	Type: Compartment
	Mode: Logical
	Tags: TissueOrgan

Container: PBPK_model_human_Ab|Organism|Liver|Pericentral
	Type: Compartment
	Mode: Logical
	Tags: TissueOrgan

Container: PBPK_model_human_Ab|Organism|Liver|Plasma
	Type: Compartment
	Mode: Logical
	Tags: Liver

Container: PBPK_model_human_Ab|Organism|Liver|BloodCells
	Type: Compartment
	Mode: Logical
	Tags: Liver

Container: PBPK_model_human_Ab|Organism|Liver|Interstitial
	Type: Compartment
	Mode: Logical
	Tags: Liver

Container: PBPK_model_human_Ab|Organism|Liver|Intracellular
	Type: Compartment
	Mode: Logical
	Tags: Liver

Container: PBPK_model_human_Ab|Organism|Liver|Endosome
	Type: Compartment
	Mode: Logical
	Tags: Liver

Container: PBPK_model_human_Ab|Organism|Liver|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Liver|Periportal|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Liver|Periportal

Container: PBPK_model_human_Ab|Organism|Liver|Periportal|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Liver|Periportal

Container: PBPK_model_human_Ab|Organism|Liver|Periportal|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Liver|Periportal

Container: PBPK_model_human_Ab|Organism|Liver|Periportal|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Liver|Periportal

Container: PBPK_model_human_Ab|Organism|Liver|Periportal|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Liver|Periportal

Container: PBPK_model_human_Ab|Organism|Liver|Periportal|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Liver|Pericentral|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Liver|Pericentral

Container: PBPK_model_human_Ab|Organism|Liver|Pericentral|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Liver|Pericentral

Container: PBPK_model_human_Ab|Organism|Liver|Pericentral|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Liver|Pericentral

Container: PBPK_model_human_Ab|Organism|Liver|Pericentral|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Liver|Pericentral

Container: PBPK_model_human_Ab|Organism|Liver|Pericentral|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Liver|Pericentral

Container: PBPK_model_human_Ab|Organism|Liver|Pericentral|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Liver|Plasma|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Liver|BloodCells|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Liver|Interstitial|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Liver|Intracellular|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Liver|Endosome|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Lung|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Lung

Container: PBPK_model_human_Ab|Organism|Lung|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Lung

Container: PBPK_model_human_Ab|Organism|Lung|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Lung

Container: PBPK_model_human_Ab|Organism|Lung|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Lung

Container: PBPK_model_human_Ab|Organism|Lung|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Lung

Container: PBPK_model_human_Ab|Organism|Lung|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Muscle|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Muscle

Container: PBPK_model_human_Ab|Organism|Muscle|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Muscle

Container: PBPK_model_human_Ab|Organism|Muscle|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Muscle

Container: PBPK_model_human_Ab|Organism|Muscle|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Muscle

Container: PBPK_model_human_Ab|Organism|Muscle|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Muscle

Container: PBPK_model_human_Ab|Organism|Muscle|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Pancreas|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Pancreas|Portal Vein Supplying Organ

Container: PBPK_model_human_Ab|Organism|Pancreas|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Pancreas|Portal Vein Supplying Organ

Container: PBPK_model_human_Ab|Organism|Pancreas|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Pancreas|Portal Vein Supplying Organ

Container: PBPK_model_human_Ab|Organism|Pancreas|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Pancreas|Portal Vein Supplying Organ

Container: PBPK_model_human_Ab|Organism|Pancreas|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Pancreas|Portal Vein Supplying Organ

Container: PBPK_model_human_Ab|Organism|Pancreas|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|PortalVein|Plasma
	Type: Compartment
	Mode: Physical
	Tags: BloodOrgan|PortalVein

Container: PBPK_model_human_Ab|Organism|PortalVein|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: BloodOrgan|PortalVein

Container: PBPK_model_human_Ab|Organism|PortalVein|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Skin|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Skin

Container: PBPK_model_human_Ab|Organism|Skin|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Skin

Container: PBPK_model_human_Ab|Organism|Skin|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Skin

Container: PBPK_model_human_Ab|Organism|Skin|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Skin

Container: PBPK_model_human_Ab|Organism|Skin|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Skin

Container: PBPK_model_human_Ab|Organism|Skin|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|Spleen|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Portal Vein Supplying Organ|Spleen

Container: PBPK_model_human_Ab|Organism|Spleen|BloodCells
	Type: Compartment
	Mode: Physical
	Tags: Portal Vein Supplying Organ|Spleen

Container: PBPK_model_human_Ab|Organism|Spleen|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Portal Vein Supplying Organ|Spleen

Container: PBPK_model_human_Ab|Organism|Spleen|Intracellular
	Type: Compartment
	Mode: Physical
	Tags: Portal Vein Supplying Organ|Spleen

Container: PBPK_model_human_Ab|Organism|Spleen|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Portal Vein Supplying Organ|Spleen

Container: PBPK_model_human_Ab|Organism|Spleen|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma
	Type: Compartment
	Mode: Physical
	Tags: Endogenous_IgG

Container: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial
	Type: Compartment
	Mode: Physical
	Tags: Endogenous_IgG

Container: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome
	Type: Compartment
	Mode: Physical
	Tags: Endogenous_IgG

Container: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_Source
	Type: Compartment
	Mode: Physical
	Tags: Endogenous_IgG

Container: PBPK_model_human_Ab|Organism|EndogenousIgG|EndosomalClearance
	Type: Compartment
	Mode: Physical
	Tags: Endogenous_IgG

Container: PBPK_model_human_Ab|Organism|Saliva|Saliva
	Type: Compartment
	Mode: Physical
	Tags: Saliva

Container: PBPK_model_human_Ab|Organism|Saliva|SalivaGland
	Type: Compartment
	Mode: Physical
	Tags: Saliva

Container: PBPK_model_human_Ab|Neighborhoods|VenousBlood_pls_VenousBlood_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|VenousBlood_pls_Lung_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|VenousBlood_bc_Lung_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_ArterialBlood_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Bone_int_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Bone_end_Bone_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Bone_int_Bone_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Bone_end_Bone_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Bone_end_Bone_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Bone_pls_Bone_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Bone_pls_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Bone_bc_VenousBlood_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Brain_pls_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Brain_end_Brain_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Brain_end_Brain_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Brain_int_Brain_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Brain_pls_Brain_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Brain_int_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Brain_bc_VenousBlood_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Brain_end_Brain_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Fat_end_Fat_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Fat_end_Fat_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Fat_int_Fat_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Fat_bc_VenousBlood_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Fat_end_Fat_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Fat_pls_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Fat_pls_Fat_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Fat_int_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Gonads_bc_VenousBlood_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Gonads_end_Gonads_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Gonads_end_Gonads_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Gonads_end_Gonads_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Gonads_pls_Gonads_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Gonads_int_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Gonads_int_Gonads_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Heart_int_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Heart_pls_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Heart_pls_Heart_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Heart_int_Heart_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Heart_end_Heart_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Heart_end_Heart_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Heart_end_Heart_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Heart_bc_VenousBlood_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Kidney_bc_VenousBlood_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_PortalVein_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_bc_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Kidney_int_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Kidney_cell_Kidney_ur|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_Kidney_ur|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Kidney_pls_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Kidney_end_Kidney_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Kidney_end_Kidney_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_UpperJejunum_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Kidney_end_Kidney_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Kidney_int_Kidney_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Lumen_uje|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_Lumen_lil|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Lumen_colasc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_Lumen_uil|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_Lumen_cae|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_Lumen_coltrans|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_Lumen_coldesc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_Lumen_rect|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Lumen_fec|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_Lumen_colsigm|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_uje_Lumen_lje|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_PortalVein_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_lje_LowerJejunum_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_sto_Lumen_duo|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_bc_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperIleum_bc_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_PortalVein_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Stomach_bc_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Stomach_end_Stomach_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Stomach_end_Stomach_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Stomach_end_Stomach_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Stomach_int_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Stomach_pls_Stomach_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Stomach_int_Stomach_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_uil_UpperIleum_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_PortalVein_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_end_SmallIntestine_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_bc_LowerJejunum_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_LowerJejunum_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_LowerJejunum_pls|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_PortalVein_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_lil_LowerIleum_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_bc_UpperIleum_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_UpperIleum_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_UpperIleum_pls|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_SmallIntestine_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerIleum_bc_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_PortalVein_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_bc_LowerIleum_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_LowerIleum_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_LowerIleum_pls|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_bc_Duodenum_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_SmallIntestine_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_end_SmallIntestine_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_end_SmallIntestine_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_UpperJejunum_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_UpperJejunum_pls|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_Duodenum_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_pls_Duodenum_pls|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_int_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_bc_UpperJejunum_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|SmallIntestine_bc_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_end_LargeIntestine_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_end_LargeIntestine_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_end_LargeIntestine_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_LargeIntestine_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_PortalVein_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_int_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_LargeIntestine_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_ColonDescendens_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_ColonDescendens_pls|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_ColonTransversum_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_ColonTransversum_pls|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_ColonAscendens_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_ColonAscendens_pls|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_Caecum_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_ColonDescendens_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_ColonTransversum_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_ColonAscendens_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_ColonSigmoid_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_ColonSigmoid_pls|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_Caecum_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_Caecum_pls|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_Rectum_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_Rectum_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_pls_Rectum_pls|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LargeIntestine_bc_ColonSigmoid_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Gallbladder_Lumen_duo|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Periportal_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_int_Periportal_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_end_Periportal_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_end_Periportal_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_Pericentral_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pericentral_end_Pericentral_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pericentral_end_Pericentral_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_Pericentral_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lung_end_Lung_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lung_end_Lung_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lung_int_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lung_pls_ArterialBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lung_int_Lung_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lung_bc_ArterialBlood_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lung_end_Lung_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lung_pls_Lung_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Muscle_end_Muscle_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Muscle_int_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Muscle_int_Muscle_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Muscle_end_Muscle_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Muscle_end_Muscle_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Muscle_bc_VenousBlood_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Muscle_pls_Muscle_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_Pancreas_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_Pancreas_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pancreas_end_Pancreas_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pancreas_end_Pancreas_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pancreas_end_Pancreas_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pancreas_int_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pancreas_pls_PortalVein_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pancreas_bc_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_PortalVein_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Rectum_bc_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_rect_Rectum_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|PortalVein_pls_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Skin_pls_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Skin_end_Skin_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Skin_int_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Skin_bc_VenousBlood_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Skin_end_Skin_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Skin_end_Skin_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Skin_int_Skin_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Skin_pls_Skin_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Spleen_end_Spleen_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Spleen_end_Spleen_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Spleen_bc_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Spleen_end_Spleen_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Spleen_int_Spleen_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Spleen_int_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_PortalVein_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Spleen_pls_Spleen_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_pls_EndogenousIgG_iggend|LigandEndo
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_pls_EndogenousIgG_iggend|FcRn
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_pls_EndogenousIgG_iggend|LigandEndo_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_iggend_EndogenousIgG_int|LigandEndo
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_iggend_EndogenousIgG_int|FcRn
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_iggend_EndogenousIgG_int|LigandEndo_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_iggsrc_EndogenousIgG_pls|LigandEndo
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_int_EndogenousIgG_pls|LigandEndo
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_int_EndogenousIgG_pls|FcRn
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_int_EndogenousIgG_pls|LigandEndo_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|EndogenousIgG_iggend_EndogenousIgG_ecl|LigandEndo
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Saliva_slv_Saliva_slv|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Duodenum_end_Duodenum_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Duodenum_end_Duodenum_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Duodenum_end_Duodenum_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Duodenum_int_Duodenum_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_Duodenum_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_end_UpperJejunum_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_pls_UpperJejunum_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_int_UpperJejunum_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_end_UpperJejunum_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_end_UpperJejunum_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_int_LowerJejunum_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_end_LowerJejunum_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_end_LowerJejunum_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_pls_LowerJejunum_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_end_LowerJejunum_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperIleum_end_UpperIleum_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperIleum_end_UpperIleum_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperIleum_int_UpperIleum_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperIleum_end_UpperIleum_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperIleum_pls_UpperIleum_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerIleum_end_LowerIleum_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerIleum_int_LowerIleum_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerIleum_end_LowerIleum_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerIleum_end_LowerIleum_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerIleum_pls_LowerIleum_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Caecum_end_Caecum_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Caecum_end_Caecum_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Caecum_end_Caecum_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Caecum_int_Caecum_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_Caecum_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_end_ColonAscendens_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_end_ColonAscendens_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_int_ColonAscendens_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_end_ColonAscendens_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_ColonAscendens_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_ColonTransversum_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_int_ColonTransversum_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_end_ColonTransversum_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_end_ColonTransversum_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_end_ColonTransversum_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_int_ColonDescendens_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_ColonDescendens_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_end_ColonDescendens_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_end_ColonDescendens_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_end_ColonDescendens_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_int_ColonSigmoid_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_end_ColonSigmoid_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_end_ColonSigmoid_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_end_ColonSigmoid_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_ColonSigmoid_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Rectum_int_Rectum_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_end|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Rectum_pls_Rectum_end|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Rectum_end_Rectum_int|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Rectum_end_Rectum_int|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Rectum_end_Rectum_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Duodenum_pls_PortalVein_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Duodenum_bc_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_duo_Duodenum_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_bc_Bone_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_LargeIntestine_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_bc_SmallIntestine_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_bc_Spleen_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_bc_Stomach_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_Bone_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_Brain_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_Fat_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_Gonads_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_Kidney_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_Muscle_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_Pancreas_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_Skin_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_SmallIntestine_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_Spleen_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_Stomach_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_Heart_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_bc_Skin_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_bc_Brain_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_bc_Fat_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_bc_Gonads_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_bc_Heart_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_bc_Kidney_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_bc_LargeIntestine_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_bc_Pancreas_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_bc_Muscle_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_bc_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_pls_PortalVein_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_coldesc_ColonDescendens_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_bc_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_pls_PortalVein_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_coltrans_ColonTransversum_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_bc_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_bc_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_pls_PortalVein_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_colasc_ColonAscendens_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Caecum_bc_PortalVein_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Caecum_pls_PortalVein_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_cae_Caecum_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_pls_PortalVein_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Lumen_colsigm_ColonSigmoid_cell|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonDescendens_cell__VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonTransversum_cell__VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonAscendens_cell__VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Caecum_cell__VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerIleum_cell__VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperIleum_cell__VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|UpperJejunum_cell__VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|LowerJejunum_cell__VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ColonSigmoid_cell__VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Rectum_cell__VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Duodenum_cell__VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_int_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pericentral_cell_Gallbladder|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_cell_Gallbladder|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pericentral_pls_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pericentral_cell_Lumen_duo|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_end_Organism_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pericentral_end_Organism_ecl|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_cell_Lumen_duo|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_bc_Pericentral_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pericentral_int_VenousBlood_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Pericentral_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_pls_Pericentral_pls|CDA1-FcRn_Complex
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_bc_Periportal_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|ArterialBlood_pls_Periportal_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|PortalVein_bc_Periportal_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|PortalVein_pls_Periportal_pls|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Pericentral_bc_VenousBlood_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Neighborhoods|Periportal_bc_VenousBlood_bc|CDA1
	Type: Molecule
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008
	Type: EventGroup
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1
	Type: Application
	Mode: Logical
	Tags: Application|Application_1|ApplicationRoot

Container: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2
	Type: Application
	Mode: Logical
	Tags: Application|Application_2|ApplicationRoot

Container: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|Application_StartEvent
	Type: Other
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|Application_StopEvent
	Type: Other
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|ProtocolSchemaItem
	Type: Other
	Mode: Logical
	Tags: Application|Application_1

Container: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|Application_StartEvent
	Type: Other
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|Application_StopEvent
	Type: Other
	Mode: Logical
	Tags: 

Container: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|ProtocolSchemaItem
	Type: Other
	Mode: Logical
	Tags: Application|Application_2

--------------- MOLECULE_START_FORMULAS (Non zero only) ----------
Molecule: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo
	Value: 116.681504184517 [µmol]
	Formula: C_pls_0 * V
		C_pls_0: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Start concentration of free endogenous IgG (plasma)(70 [µmol/l])
		V: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Volume(1.66687863120739 [l])

Molecule: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|FcRn
	Value: 1.22914255534983 [µmol]
	Formula: krpls <= 0 ? 0 : (kep*Cpl*ka*FcRnEnd*Ve*(k_diff_int*kpe+kie*k_conv+kie*k_diff_pls+kie*kpe+Ql*kpe)/((kdeg*kep*Ql+kdeg*kep*kie+kdeg*kep*k_diff_int+ka*FcRnEnd*Ve*kei*Ql+ka*FcRnEnd*Ve*kei*k_diff_int+ka*FcRnEnd*Ve*kep*Ql+ka*FcRnEnd*Ve*kep*kie+ka*FcRnEnd*Ve*kep*k_diff_int+kdeg*Kd*ka*Ve*Ql+kdeg*Kd*ka*Ve*kie+kdeg*Kd*ka*Ve*k_diff_int+kdeg*kei*Ql+kdeg*kei*kie+kdeg*kei*k_diff_int)*krpls))*V_pls
		Ve: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])
		V_pls: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Volume(1.66687863120739 [l])
		k_conv: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_conv(0.000799102869318376 [l/min])
		k_diff_int: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_int(0.00152160685833196 [l/min])
		k_diff_pls: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_pls(0.00152160685833196 [l/min])
		kdeg: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kdeg(0.00367858098529322 [l/min])
		kei: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kei(0 [l/min])
		kep: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kep(0.00159190054334327 [l/min])
		kie: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kie(0 [l/min])
		kpe: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kpe(0.00527048152863649 [l/min])
		ka: PBPK_model_human_Ab|Organism|EndogenousIgG|kass (FcRn, endogenous IgG)(0.87 [l/µmol/min])
		Kd: PBPK_model_human_Ab|Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in endosomal space(0.63 [µmol/l])
		krpls: PBPK_model_human_Ab|Organism|EndogenousIgG|krpls(0.490062317574971 [l/min])
		Ql: PBPK_model_human_Ab|Organism|EndogenousIgG|Lymph flow rate(0.0140728079701645 [l/min])
		FcRnEnd: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Start concentration of free FcRn (endosome)(80.8 [µmol/l])
		Cpl: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Start concentration of free endogenous IgG (plasma)(70 [µmol/l])

Molecule: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|LigandEndo_Complex
	Value: 0.00864553442897442 [µmol]
	Formula: krpls <= 0 ? 0 : (kep*Cpl*FcRnEnd*Ve*(k_diff_int*kpe+kie*k_conv+kie*k_diff_pls+kie*kpe+Ql*kpe)*(ka*Cpl*Vpls+krpls)/((kdeg*kep*Ql+kdeg*kep*kie+kdeg*kep*k_diff_int+ka*FcRnEnd*Ve*kei*Ql+ka*FcRnEnd*Ve*kei*k_diff_int+ka*FcRnEnd*Ve*kep*Ql+ka*FcRnEnd*Ve*kep*kie+ka*FcRnEnd*Ve*kep*k_diff_int+kdeg*Kd*ka*Ve*Ql+kdeg*Kd*ka*Ve*kie+kdeg*Kd*ka*Ve*k_diff_int+kdeg*kei*Ql+kdeg*kei*kie+kdeg*kei*k_diff_int)*krpls*Kdn*Vpls))*Vpls
		Ve: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])
		Vpls: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Volume(1.66687863120739 [l])
		k_conv: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_conv(0.000799102869318376 [l/min])
		k_diff_int: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_int(0.00152160685833196 [l/min])
		k_diff_pls: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_pls(0.00152160685833196 [l/min])
		kdeg: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kdeg(0.00367858098529322 [l/min])
		kei: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kei(0 [l/min])
		kep: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kep(0.00159190054334327 [l/min])
		kie: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kie(0 [l/min])
		kpe: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kpe(0.00527048152863649 [l/min])
		ka: PBPK_model_human_Ab|Organism|EndogenousIgG|kass (FcRn, endogenous IgG)(0.87 [l/µmol/min])
		Kd: PBPK_model_human_Ab|Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in endosomal space(0.63 [µmol/l])
		Kdn: PBPK_model_human_Ab|Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in plasma/interstitial(10000 [µmol/l])
		krpls: PBPK_model_human_Ab|Organism|EndogenousIgG|krpls(0.490062317574971 [l/min])
		Ql: PBPK_model_human_Ab|Organism|EndogenousIgG|Lymph flow rate(0.0140728079701645 [l/min])
		FcRnEnd: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Start concentration of free FcRn (endosome)(80.8 [µmol/l])
		Cpl: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Start concentration of free endogenous IgG (plasma)(70 [µmol/l])

Molecule: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo
	Value: 113.620509532146 [µmol]
	Formula: (Cpl*(kdeg*kep*k_diff_pls+kdeg*kep*k_conv+ka*FcRnEnd*Ve*kei*k_diff_pls+ka*FcRnEnd*Ve*kei*k_conv+kdeg*kei*k_conv+ka*FcRnEnd*Ve*kep*k_diff_pls+ka*FcRnEnd*Ve*kep*k_conv+kdeg*Kd*ka*Ve*k_diff_pls+kdeg*Kd*ka*Ve*k_conv+kpe*ka*FcRnEnd*Ve*kei+kdeg*kei*k_diff_pls)/(kdeg*kep*Ql+kdeg*kep*kie+kdeg*kep*k_diff_int+ka*FcRnEnd*Ve*kei*Ql+ka*FcRnEnd*Ve*kei*k_diff_int+ka*FcRnEnd*Ve*kep*Ql+ka*FcRnEnd*Ve*kep*kie+ka*FcRnEnd*Ve*kep*k_diff_int+kdeg*Kd*ka*Ve*Ql+kdeg*Kd*ka*Ve*kie+kdeg*Kd*ka*Ve*k_diff_int+kdeg*kei*Ql+kdeg*kei*kie+kdeg*kei*k_diff_int))*V_int
		Ve: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])
		V_int: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|Volume(10.9070411740154 [l])
		k_conv: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_conv(0.000799102869318376 [l/min])
		k_diff_int: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_int(0.00152160685833196 [l/min])
		k_diff_pls: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_pls(0.00152160685833196 [l/min])
		kdeg: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kdeg(0.00367858098529322 [l/min])
		kei: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kei(0 [l/min])
		kep: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kep(0.00159190054334327 [l/min])
		kie: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kie(0 [l/min])
		kpe: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kpe(0.00527048152863649 [l/min])
		ka: PBPK_model_human_Ab|Organism|EndogenousIgG|kass (FcRn, endogenous IgG)(0.87 [l/µmol/min])
		Kd: PBPK_model_human_Ab|Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in endosomal space(0.63 [µmol/l])
		Ql: PBPK_model_human_Ab|Organism|EndogenousIgG|Lymph flow rate(0.0140728079701645 [l/min])
		FcRnEnd: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Start concentration of free FcRn (endosome)(80.8 [µmol/l])
		Cpl: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Start concentration of free endogenous IgG (plasma)(70 [µmol/l])

Molecule: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|FcRn
	Value: 0 [µmol]
	Formula: krint <= 0 ? 0 : (kei*Cpl*ka*FcRnEnd*Ve*(k_diff_int*kpe+kie*k_conv+kie*k_diff_pls+kie*kpe+Ql*kpe)/((kdeg*kep*Ql+kdeg*kep*kie+kdeg*kep*k_diff_int+ka*FcRnEnd*Ve*kei*Ql+ka*FcRnEnd*Ve*kei*k_diff_int+ka*FcRnEnd*Ve*kep*Ql+ka*FcRnEnd*Ve*kep*kie+ka*FcRnEnd*Ve*kep*k_diff_int+kdeg*Kd*ka*Ve*Ql+kdeg*Kd*ka*Ve*kie+kdeg*Kd*ka*Ve*k_diff_int+kdeg*kei*Ql+kdeg*kei*kie+kdeg*kei*k_diff_int)*krint))*V_int
		Ve: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])
		V_int: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|Volume(10.9070411740154 [l])
		k_conv: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_conv(0.000799102869318376 [l/min])
		k_diff_int: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_int(0.00152160685833196 [l/min])
		k_diff_pls: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_pls(0.00152160685833196 [l/min])
		kdeg: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kdeg(0.00367858098529322 [l/min])
		kei: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kei(0 [l/min])
		kep: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kep(0.00159190054334327 [l/min])
		kie: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kie(0 [l/min])
		kpe: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kpe(0.00527048152863649 [l/min])
		ka: PBPK_model_human_Ab|Organism|EndogenousIgG|kass (FcRn, endogenous IgG)(0.87 [l/µmol/min])
		Kd: PBPK_model_human_Ab|Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in endosomal space(0.63 [µmol/l])
		krint: PBPK_model_human_Ab|Organism|EndogenousIgG|krint(0 [l/min])
		Ql: PBPK_model_human_Ab|Organism|EndogenousIgG|Lymph flow rate(0.0140728079701645 [l/min])
		FcRnEnd: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Start concentration of free FcRn (endosome)(80.8 [µmol/l])
		Cpl: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Start concentration of free endogenous IgG (plasma)(70 [µmol/l])

Molecule: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|LigandEndo_Complex
	Value: 0 [µmol]
	Formula: krint <= 0 ? 0 : (kei*Cpl*FcRnEnd*Ve*(k_diff_int*kpe+kie*k_conv+kie*k_diff_pls+kie*kpe+Ql*kpe)*(krint*kdeg*Kd*ka*Ve*k_diff_int+krint*kdeg*kei*Ql+krint*kdeg*Kd*ka*Ve*kie+krint*kdeg*kei*kie+krint*kdeg*Kd*ka*Ve*Ql+krint*kdeg*kei*k_diff_int+krint*ka*FcRnEnd*Ve*kep*k_diff_int+krint*ka*FcRnEnd*Ve*kep*kie+krint*ka*FcRnEnd*Ve*kep*Ql+ka^2*Cpl*Vint*kpe*FcRnEnd*Ve*kei+ka^2*Cpl*Vint*kdeg*Kd*Ve*k_conv+ka^2*Cpl*Vint*kdeg*Kd*Ve*k_diff_pls+ka*Cpl*Vint*kdeg*kei*k_diff_pls+ka^2*Cpl*Vint*FcRnEnd*Ve*kep*k_conv+ka^2*Cpl*Vint*FcRnEnd*Ve*kep*k_diff_pls+ka*Cpl*Vint*kdeg*kei*k_conv+krint*kdeg*kep*Ql+ka^2*Cpl*Vint*FcRnEnd*Ve*kei*k_conv+ka^2*Cpl*Vint*FcRnEnd*Ve*kei*k_diff_pls+ka*Cpl*Vint*kdeg*kep*k_conv+krint*kdeg*kep*kie+ka*Cpl*Vint*kdeg*kep*k_diff_pls+krint*kdeg*kep*k_diff_int+krint*ka*FcRnEnd*Ve*kei*Ql+krint*ka*FcRnEnd*Ve*kei*k_diff_int) / ((kdeg*kep*Ql+kdeg*kep*kie+kdeg*kep*k_diff_int+ka*FcRnEnd*Ve*kei*Ql+ka*FcRnEnd*Ve*kei*k_diff_int+ka*FcRnEnd*Ve*kep*Ql+ka*FcRnEnd*Ve*kep*kie+ka*FcRnEnd*Ve*kep*k_diff_int+kdeg*Kd*ka*Ve*Ql+kdeg*Kd*ka*Ve*kie+kdeg*Kd*ka*Ve*k_diff_int+kdeg*kei*Ql+kdeg*kei*kie+kdeg*kei*k_diff_int)^2*krint*Kdn*Vint))*Vint
		Ve: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])
		Vint: PBPK_model_human_Ab|Organism|EndogenousIgG|Interstitial|Volume(10.9070411740154 [l])
		k_conv: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_conv(0.000799102869318376 [l/min])
		k_diff_int: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_int(0.00152160685833196 [l/min])
		k_diff_pls: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_pls(0.00152160685833196 [l/min])
		kdeg: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kdeg(0.00367858098529322 [l/min])
		kei: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kei(0 [l/min])
		kep: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kep(0.00159190054334327 [l/min])
		kie: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kie(0 [l/min])
		kpe: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kpe(0.00527048152863649 [l/min])
		ka: PBPK_model_human_Ab|Organism|EndogenousIgG|kass (FcRn, endogenous IgG)(0.87 [l/µmol/min])
		Kd: PBPK_model_human_Ab|Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in endosomal space(0.63 [µmol/l])
		Kdn: PBPK_model_human_Ab|Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in plasma/interstitial(10000 [µmol/l])
		krint: PBPK_model_human_Ab|Organism|EndogenousIgG|krint(0 [l/min])
		Ql: PBPK_model_human_Ab|Organism|EndogenousIgG|Lymph flow rate(0.0140728079701645 [l/min])
		FcRnEnd: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Start concentration of free FcRn (endosome)(80.8 [µmol/l])
		Cpl: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Start concentration of free endogenous IgG (plasma)(70 [µmol/l])

Molecule: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo
	Value: 0.0368703495697085 [µmol]
	Formula: (Cpl*(k_diff_int*kpe+kie*k_conv+kie*k_diff_pls+kie*kpe+Ql*kpe)*(Kd*ka*Ve+kep+kei)/(kdeg*kep*Ql+kdeg*kep*kie+kdeg*kep*k_diff_int+ka*FcRnEnd*Ve*kei*Ql+ka*FcRnEnd*Ve*kei*k_diff_int+ka*FcRnEnd*Ve*kep*Ql+ka*FcRnEnd*Ve*kep*kie+ka*FcRnEnd*Ve*kep*k_diff_int+kdeg*Kd*ka*Ve*Ql+kdeg*Kd*ka*Ve*kie+kdeg*Kd*ka*Ve*k_diff_int+kdeg*kei*Ql+kdeg*kei*kie+kdeg*kei*k_diff_int))*Ve
		Ve: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])
		k_conv: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_conv(0.000799102869318376 [l/min])
		k_diff_int: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_int(0.00152160685833196 [l/min])
		k_diff_pls: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_pls(0.00152160685833196 [l/min])
		kdeg: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kdeg(0.00367858098529322 [l/min])
		kei: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kei(0 [l/min])
		kep: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kep(0.00159190054334327 [l/min])
		kie: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kie(0 [l/min])
		kpe: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kpe(0.00527048152863649 [l/min])
		ka: PBPK_model_human_Ab|Organism|EndogenousIgG|kass (FcRn, endogenous IgG)(0.87 [l/µmol/min])
		Kd: PBPK_model_human_Ab|Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in endosomal space(0.63 [µmol/l])
		Ql: PBPK_model_human_Ab|Organism|EndogenousIgG|Lymph flow rate(0.0140728079701645 [l/min])
		FcRnEnd: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Start concentration of free FcRn (endosome)(80.8 [µmol/l])
		Cpl: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Start concentration of free endogenous IgG (plasma)(70 [µmol/l])

Molecule: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|FcRn
	Value: 1.44848607997901 [µmol]
	Formula: C_endo_0 * V
		C_endo_0: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Start concentration of free FcRn (endosome)(80.8 [µmol/l])
		V: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])

Molecule: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|LigandEndo_Complex
	Value: 4.06945846027984 [µmol]
	Formula: (Cpl*ka*FcRnEnd*Ve*(k_diff_int*kpe+kie*k_conv+kie*k_diff_pls+kie*kpe+Ql*kpe)/(kdeg*kep*Ql+kdeg*kep*kie+kdeg*kep*k_diff_int+ka*FcRnEnd*Ve*kei*Ql+ka*FcRnEnd*Ve*kei*k_diff_int+ka*FcRnEnd*Ve*kep*Ql+ka*FcRnEnd*Ve*kep*kie+ka*FcRnEnd*Ve*kep*k_diff_int+kdeg*Kd*ka*Ve*Ql+kdeg*Kd*ka*Ve*kie+kdeg*Kd*ka*Ve*k_diff_int+kdeg*kei*Ql+kdeg*kei*kie+kdeg*kei*k_diff_int))*Ve
		Ve: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Volume(0.0179268079205323 [l])
		k_conv: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_conv(0.000799102869318376 [l/min])
		k_diff_int: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_int(0.00152160685833196 [l/min])
		k_diff_pls: PBPK_model_human_Ab|Organism|EndogenousIgG|igg_k_diff_pls(0.00152160685833196 [l/min])
		kdeg: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kdeg(0.00367858098529322 [l/min])
		kei: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kei(0 [l/min])
		kep: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kep(0.00159190054334327 [l/min])
		kie: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kie(0 [l/min])
		kpe: PBPK_model_human_Ab|Organism|EndogenousIgG|IgG_kpe(0.00527048152863649 [l/min])
		ka: PBPK_model_human_Ab|Organism|EndogenousIgG|kass (FcRn, endogenous IgG)(0.87 [l/µmol/min])
		Kd: PBPK_model_human_Ab|Organism|EndogenousIgG|Kd (FcRn, endogenous IgG) in endosomal space(0.63 [µmol/l])
		Ql: PBPK_model_human_Ab|Organism|EndogenousIgG|Lymph flow rate(0.0140728079701645 [l/min])
		FcRnEnd: PBPK_model_human_Ab|Organism|EndogenousIgG|Endosome|Start concentration of free FcRn (endosome)(80.8 [µmol/l])
		Cpl: PBPK_model_human_Ab|Organism|EndogenousIgG|Plasma|Start concentration of free endogenous IgG (plasma)(70 [µmol/l])

Molecule: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|CDA1
	Value: 0.584000000823388 [µmol]
	Formula: DrugMass
		DrugMass: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_1|ProtocolSchemaItem|DrugMass(0.584000000823388 [µmol])

Molecule: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|CDA1
	Value: 9.14933334623307 [µmol]
	Formula: DrugMass
		DrugMass: PBPK_model_human_Ab|Applications|IV_20mgkg_infusion_Taylor2008|Application_2|ProtocolSchemaItem|DrugMass(9.14933334623307 [µmol])