no
yes
Below 20%
Above 20%
No mediation
Mediation
mediation
No XM interaction
PNIE/PNDE
TNIE/TNDE
Complete sample
<75 years of age
≥75 years of age
A priori
≥10% change
With hormonal factors
Without hormonal factors
Continuous
Increased weight vs. stable
Decreased weight vs. stable