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{"sheet":"Functional motifs","index":0,"n_rows":137,"n_cols":3,"rows_kept":137,"flags":["formulas_cached_only"]}
["Pattern motif","Function of protein containing the pattern","Reference (Pubmed IDs)"]
["!!!!D","Walker B motif - ATP-binding motifs","PMID: 22889913"]
["!!!!DxDxR","Walker A′ motif - ATP-binding motifs","PMID: 22889913"]
["!!!DxxP","Walker B motif - ATP-binding motifs","PMID: 22889913"]
["!!xSxS[DE][DE][DE]","SUMOylation - SUMO binding to substrate ","PMID: 26101541"]
["!Kx[DE]","SUMOylation - SUMO binding to substrate ","PMID: 26101541"]
["!PxV ","Binding to ESCRT, paramyxoviruses budding","PMID: 23435234"]
["!x!xxxx!","Caveolin scaffolding domain (CSD)","PMID: 12223531"]
["!x!xxxx!xx!","Caveolin scaffolding domain (CSD)","PMID: 12223531"]
["!xxxx!xx!","Caveolin scaffolding domain (CSD)","PMID: 12223531"]
["[AG]xxxxGK[ST]","Walker A motif, ATP-binding motifs","PMID: 22889913"]
["[DE]xxxL[LI] ","viral pathogenesis, interact with cellular clathrin adaptor proteins, sorting signal","PMID: 24843023, PMID: 25915900"]
["[ENT][HNPS][ILV]Y[ADEG]","EPIYA-related motif, interactions between bacterial effectors and host SH2 domain-containing proteins","PMID: 25475989 "]
["[GD]DIWK ","HIV release, interfering with tetherin function ","PMID: 24109238"]
["[GE][KR]Q[GE]RL","Cleavage motif of Newcastle disease virus protein","PMID: 22393889 "]
["[ILV]QxxxRGxxx[RK]","IQ motifs, Myosin superfamily","PMID: 22399849 "]
["[KR]xTQT","Dynein binding motifs, protein transport, viruses transport inside the cell (Adenovirus, ASF virus, Papilloma virus, Rabies virus, Mokola Virus and Ebolavirus)","PMID: 21777386 "]
["[LI]xCx[DE]","Binding to retinoblastoma protein","PMID: 25475989 "]
["[LIVFM]x(2-3)[LIVFM]x[LIVFM] ","Nuclear export signal (NES), regulate protein export to nucleus from cytoplasm","PMID: 15314210, PMID: 21167871, PMID: 26029198"]
["[LM]VxSxVxA","Cleavage of NS1 from the NS1-NS2A region of flavivirus","PMID: 23523765"]
["[PR]xxKR{DE}[KR]","Nuclear localization sequence (NLS) motif - Class 2, regulate import of the protein into the nucleus","PMID: 19001369, PMID: 21167871, PMID: 26029198"]
["[QE][ST]RGLF","Cleavage site for Influenza virus","PMID: 26055889 "]
["[RHK][STALV]x[ST]x[PESRDIFTQ]","Phosphoserine/threonine-binding proteins, regulation of signalling cascades","PMID: 25475989 "]
["[RK]RQ[RK]RF","Cleavage motif of Newcastle disease virus protein","PMID: 15914855, PMID: 22393889 "]
["[RK]xxxx!x!","Lyase activity, catalyzes the removal of the phosphate group from the phosphothreonine in the mitogen-activated protein kinases such as MAPK2/ERK2, MAPK3/ERK1, MAPK8 and MAPK14","PMID: 25475989 "]
["[RKY]xxPxxP","Interact with host SH3 domain","PMID: 25475989 "]
["[RP]xxKR[KR]{DE}","Nuclear localization sequence (NLS) motif - Class 4, regulate protein import into nucleus","PMID: 19001369, PMID: 21167871, PMID: 26029198"]
["[SIVL]xYxx[IVL]","ITIM motif, negative signal of immune receptors","PMID: 23874461"]
["[ST]x[VIL]","Pathogenesis, PDZ domain, C-terminl","PMID: 25475989 "]
["[VI]x[VI][VI] ","SUMOylation - SUMO binding to substrate ","PMID: 26101541"]
["Ax(3)IQx(2)FRx(4)KK","IQ motifs, Myosin superfamily","PROSITE ID PS50096, (http://prosite.expasy.org/PS50096, http://prosite.expasy.org/PDOC50096)"]
["AxxxAxxxAxxxW","Helix-Helix Interactions ","PMID: 22072710, PMID: 24574397"]
["++x+ - +++xx+","Heparan sulfate-binding motif, post-internalization of adenovirus infection","PMID: 19656960"]
["CETTG","Retroviruses fusogenic activities, syncytia and fusion","PMID: 24239536, PMID: 17959780 "]
["Cx(13-20)Cx(5-6)Cx(9-19)Cx(10-14)Cx(4-14)C","6-cysteine motif, degradation of chitin and chitotriose","PMID: 23864639, PMID: 26057202"]
["Cx2Cx6Wx3Dx5Hx6C","Inhibitor of apoptosis (IAP) - block the apoptosis, Baculovirus encode IAPs, which characterized by the presence of one or more baculoviral IAP repeat (BIR) domains","PMID: 22095281, PMID: 23741982"]
["Cx5CxnHx6C (C2HC zinc finger)","Budded virions production and nucleocapsid assembly","PMID: 23864639, PMID: 26057202"]
["CxxC","Protein interaction, thiol-disulﬁde transfer, disulﬁde isomerization, virus fusion","PMID: 23885084, PMID: 11983854, PMID: 18480461 "]
["CxxxC","protein interaction and thiol-disulﬁde transfer ","PMID: 23885084, PMID: 11983854"]
["DGE","Binding to integrins, and viral attachment to cellular receptors","PMID: 12941907, PMID: 16603530"]
["DLxxL","Binding to integrins, and viral attachment to cellular receptors","PMID: 23740982"]
["DSGxxS","Enhance virion-release, anti-tetherin activity","PMID: 23514615, PMID: 24782851 "]
["EDLY","EPIYA-related motif, interactions between bacterial effectors and host SH2 domain-containing proteins","PMID: 25475989 "]
["EHIYD","EPIYA-related motif, interactions between bacterial effectors and host SH2 domain-containing proteins","PMID: 25475989 "]
["EHLYA","EPIYA-related motif, interactions between bacterial effectors and host SH2 domain-containing proteins","PMID: 25475989 "]
["ENIYE","EPIYA-related motif, interactions between bacterial effectors and host SH2 domain-containing proteins","PMID: 25475989 "]
["EPIYA","EPIYA-related motif, interactions between bacterial effectors and host SH2 domain-containing proteins","PMID: 25475989 "]
["EPIYG","EPIYA-related motif, interactions between bacterial effectors and host SH2 domain-containing proteins","PMID: 25475989 "]
["EPIYG","EPIYA-related motif, interactions between bacterial effectors and host SH2 domain-containing proteins","PMID: 25475989 "]
["EPLYA","EPIYA-related motif, interactions between bacterial effectors and host SH2 domain-containing proteins","PMID: 25475989 "]
["EPLYA","EPIYA-related motif, interactions between bacterial effectors and host SH2 domain-containing proteins","PMID: 25475989 "]
["EPVYA","EPIYA-related motif, interactions between bacterial effectors and host SH2 domain-containing proteins","PMID: 25475989 "]
["ESIYE","EPIYA-related motif, interactions between bacterial effectors and host SH2 domain-containing proteins","PMID: 25475989 "]
["ExxxLV","Sorting signal, anti-tetherin,","PMID: 22479182"]
["G[IV]QVD","Dynein binding motifs, protein transport, viruses transport inside the cell","PMID: 21777386 "]
["GK[DE]x[ST]NPLxxxxLxK ","Suppression of RNA silencing, salicylic acid dependent defence responses and signalling ","PMID: 24088344 "]
["GKYLQRRLQ","Putative RNA-binding motif in porcine reproductive and respiratory syndrome virus","PMID: 24825891 "]
["GPG[RQ] ","HIV neutralization by human antibodies ","PMID: 1916888, PMID: 15588347"]
["Gx(1-2)GxxG","Protein folding, Rossmann folds motifs, and bind FAD or NAD(P)","PMID: 12368099"]
["Gxxx[GA]","Protein folding, Rossmann folds motifs, and bind FAD or NAD(P)","PMID: 12368099"]
["GxxxG","Protein folding, Rossmann folds motifs, and bind FAD or NAD(P)","PMID: 21507970, PMID: 24569864"]
["HxCx[ST]WxS","Pentraxin domain, pathogen recognition, inﬂammation, host defense, and antiviral response","PMID: 21716666, PMID: 22665991"]
["HxxxW","Proton transport, protein’s channel function, transmembrane domain, and viral replication","PMID: 20451491, PMID: 20926635, PMID: 16761092, PMID: 18408016"]
["IDA","Binding to integrins, and viral attachment to cellular receptors","PMID: 16298987 "]
["K[KR]RK","Nuclear localization sequence (NLS) motif - Class 1, regulate protein import into nucleus","PMID: 19001369, PMID: 21167871, PMID: 26029198"]
["KDEL","NAD+ ADP-ribosyltransferase activity, ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein","PMID: 25475989 "]
["KGD or KGE","Viral attachment to cellular receptors","PMID: 23740982"]
["KKKRGLF ","Cleavage site for Influenza A virus hemagglutinin","PMID: 26095298 "]
["KKTK","Heparan sulfate-binding motif, post-internalization steps of adenovirus infection","PMID: 19656960, PMID: 17855526, PMID: 16160140, PMID: 19647886"]
["KLGxGLxF[DN]","Adenovirus fiber flexibility motif ","PMID: 19656960"]
["KR[KR]R","Nuclear localization sequence (NLS) motif - Class 1, regulate protein import into nucleus","PMID: 19001369, PMID: 21167871, PMID: 26029198"]
["KRAR","Adenovirus nuclear localization signal (NLS)","PMID: 1962447, PMID: 24142408"]
["KRIHIGPGRAFYTT","HIV neutralization by human antibodies ","PMID: 12575942 "]
["KRx(10-12)K[KR][KR]","Nuclear localization sequence (NLS) motif - Bipartite, regulate protein import into nucleus","PMID: 19001369, PMID: 21167871, PMID: 26029198"]
["KRx(10-12)K[KR]X[KR]","Nuclear localization sequence (NLS) motif - Bipartite, regulate protein import into nucleus","PMID: 19001369, PMID: 21167871, PMID: 26029198"]
["KRx[WFY]xxAF","Nuclear localization sequence (NLS) motif - Class 3, regulate protein import into nucleus","PMID: 19001369, PMID: 21167871, PMID: 26029198"]
["KRxR","Nuclear localization sequence (NLS) motif, regulate protein import into nucleus, influenza B virus nucleoprotein","PMID: 23689061, PMID: 25122787"]
["KRxxPxGPDPxH","Mimics host plant CLE extracellular signal peptides that regulate cell fate, cell differentiation","PMID: 25475989 "]
["KSS[RG]LF","Cleavage site of H9N2 avian influenza virus","PMID: 26055889 "]
["KxGFFKR","Adhesion protein motif","PMID: 24001772"]
["KxGGLxF[DN] ","Adenovirus fiber flexibility motif ","PMID: 19656960"]
["L!x![DE]","Clathrin-binding motifs, clathrin-box","PMID: 22239657 "]
["L[FL][VI]F[VIL]LE[LF]LLxF","Agnoprotein function, productive viral infection","PMID: 23747198"]
["L[LI][DEN][LF][DE]","Clathrin-binding motifs, clathrin-box","PMID: 22239657 "]
["LDI","Binding to integrins, and viral attachment to cellular receptors","PMID: 11513858, PMID: 16298987 "]
["LDV","Binding to integrins, and viral attachment to cellular receptors","PMID: 11513858, PMID: 16298987 "]
["LGKR[KR][WFY]","Nuclear localization sequence (NLS) motif - Class 5, regulate protein import into nucleus","PMID: 19001369, PMID: 21167871, PMID: 26029198"]
["LGxGxxIxW","Regulation of APOBEC3 proteins","PMID: 20592083, PMID: 20335268, PMID: 24418547, PMID: 23202519"]
["LPxTG","Sortases, adhesion protein, transpeptidase, virulence factors, fibrinogen-binding, cell wall anchoring, and adhesion of bacteria to the oral cavity","PMID: 10754567, PMID: 19383683 "]
["LRGG ","ISGylation, antiviral response","PMID: 24095857"]
["LxCxE","Binding of virus proteins to retinoblastoma protein and gene expression modulation, virus replication","PMID: 15078963, PMID: 16299528, PMID: 23514892, PMID: 25681708, PMID: 24371076, PMID: 23514892, PMID: 24371076, PMID: 24027329"]
["LxxLL ","Induction of cellular-malignant transformation by Kaposin, activation of cap-dependent translation, and HIV retrotransposition","PMID: 15684715, PMID: 19458171, PMID: 22553330"]
["LYPxL ","Recruits ESCRT machinery, retroviruses release and replication ","PMID: 20392845"]
["N{P}[ST]{P}","Glycosylation sites ","PROSITE ID: PDOC00001, (http://prosite.expasy.org/PDOC00001)"]
["NPLYE","EPIYA-related motif, interactions between bacterial effectors and host SH2 domain-containing proteins","PMID: 25475989 "]
["NYx[EK]C[LI][KIR][NT]APYID","Interact with EPB41 (red blood cell cytoskeleton)","PMID: 25475989 "]
["P[TS]AP","Recruit ESCRT pathway, mediates viral budding and release","PMID: 24034610, PMID: 25105277, PMID: 23435234"]
["PHQ","Retroviruses fusogenic activities, syncytia and fusion","PMID: 24239536, PMID: 10590117"]
["PPLP ","Regulation of APOBEC3 proteins","PMID: 24422669"]
["PPxY","Protein ubiquitylation, Interaction with Nedd4 E3 ubiquitin ligases, Recruit ESCRT pathway, and mediates virus entry, cellular microtubule-dependent trafficking, budding, and release","PMID: 20333243, PMID: 17433711, PMID: 19081591, PMID: 24034610, PMID: 25105277, PMID: 23435234"]
["PWxxW ","Clathrin-binding motifs, W-box","PMID: 22239657 "]
["PxxP","Interact with clathrin adaptor protein, anti-tethrin","PMID: 15047914, PMID: 18073204, PMID: 24465204"]
["PxxPx[KR]","Interact with host SH3 domain","PMID: 25475989 "]
["RGD","Binding to integrins, and viral attachment to cellular receptors","PMID: 23607394, PMID: 15613334, PMID: 16160140, PMID: 20376613, PMID: 23740480"]
["RGDLxxL","Binding to integrins, and viral attachment to cellular receptors","PMID: 25645358"]
["RKRP","Nuclear localization signal in fowl adenoviruses ","PMID: 24142408"]
["RRRRx(5)Rx(4)RK","The agnoprotein, Nuclear localization signal (NLS) motif, regulate protein import into nucleus","PMID: 22726243 "]
["RSS[RG]LF","Cleavage site of protein of H9N2 avian influenza vaccine strain","PMID: 26055889 "]
["Rx[LC]","Required for immediate early gene expression of cytomegalovirus","PMID: 24101496 "]
["Rx[RK]RGLF ","The cleavage site of Influenza virus protein","PMID: 26095298 "]
["Rx{P}[ST]{P}P","Phosphoserine/threonine-binding proteins, regulation of signalling cascades","PMID: 25475989 "]
["RxL!","Required for immediate early gene expression of cytomegalovirus","PMID: 24101496 "]
["RxLR","Mediate entry of Phytophthora sojae, bind phospholipids, PtdIns-3-P, and mediate lipid raft-mediated endocytosis","PMID: 18621946, PMID: 22403824 "]
["RxLX!","Required for immediate early gene expression of cytomegalovirus","PMID: 24101496 "]
["RxLx[EQD]","Exports Plasmodium falciparum proteins into erythrocyte ","PMID: 25878772 "]
["RxRRGLF ","The cleavage site of Influenza virus protein","PMID: 26095298 "]
["Rxx{P}[ST][IVLM]x","Phosphoserine/threonine-binding proteins, regulation of signalling cascades","PMID: 25475989 "]
["RxxK","Regulates endocytosis, endosome sorting, Interact with host SH3 domain, and mediate AMSH interaction  with SH3 domains of STAM and Grb2 families","PMID: 20159979, PMID: 25475989 "]
["RxxRGLF ","The cleavage site of Influenza virus protein","PMID: 26095298 "]
["SDI","Binding to integrins, and viral attachment to cellular receptors","PMID: 23514881"]
["SLxYLA","Regulation of APOBEC3 proteins","PMID: 24422669"]
["SVSVGMKPSPRP","Adhesion protein motif","PMID: 23183721"]
["T[QDE]x(5)Adx(2)[IL]","Regulation and interaction with APOBEC3G, APOBEC3F and Cullin5","PMID: 20592083, PMID: 19535447"]
["TPLYA","EPIYA-related motif, interactions between bacterial effectors and host SH2 domain-containing proteins","PMID: 25475989 "]
["VxHxMY","Regulation of APOBEC3 proteins, Binding of HIV-Vif to human APOBEC3G, ElonginB and C, and Cullin5","PMID: 24422669"]
["VxxxIxxLxxxL","Helix-helix interactions ","PMID: 22072710, PMID: 24574397"]
["W[ST]xCxVTCG","Cell surface of Plasmodium falciparum, thrombospondin type-1 (TSP1) repeat profile, adhesive, and immunodominant surface antigen on the sporozoite (the infective stage of the malaria parasite that is transmitted from the mosquito to the vertebrate host)","PMID: 25475989 "]
["WxxF","Mediate binding of endocytic protein NECAP-1 to a C-terminal of clathrin adaptor protein 2","PMID: 9525900, PMID: 15359277, PMID: 24130457, PMID: 22606007"]
["WxxxWx(9)W","Tumor necrosis factor receptor-associated factor 6 (TRAF6) binding, Trp-rich motif","PMID: 23678181"]
["x(3)!x(3)!x(3)!x(5)","Pathogenesis, Required for efficient pedestal formation in host epithelial cells during infection","PMID: 25475989 "]
["xx[PV]xxP","Interact with host SH3 domain, directly binds and activates WASL/N-WASP, and pathogenesis","PMID: 25475989 "]
["xYxDx","Interact with CASP4","PMID: 25475989 "]
["YGL","Binding to integrins, and viral attachment to cellular receptors","PMID: 11513858, PMID: 16298987 "]
["Yxx[LI]x(6-8)Yxx[LI]","ITAM motif, positive signal of immune receptors","PMID: 23874461"]
["YxxL","Recruit ESCRT pathway, viral budding and release","PMID: 19109396, PMID: 24034610, PMID: 25105277, PMID: 23435234"]
["YxxΦ ","Necessary for endocytosis, intracellular trafficking, interact with clathrin adaptor protein, anti-tethrin, promote viral spread, and viral fusion, replication and pathogenesis, ","PMID: 11489622, PMID: 18073204, PMID: 23843643, PMID: 24465204, PMID: 24762043"]
["YxYxxΦ ","Interact with clathrin adaptor protein, anti-tethrin, and promote viral spread","PMID: 24843023"]