gene_id BaseMean_DESeq2 BaseMean_control_YD BaseMean_case_WNT5A FoldChange log2FoldChange p-value q-value Regulation Expression_WNT5A1 Expression_WNT5A2 Expression_WNT5A3 Expression_YD1 Expression_YD2 gene_Dbxref description GO_id GO_term pathway pathway_description TF_family Acacb 21.660892090367238 6.085241523159915 32.04465913517212 5.264249244978519 2.396227797580329 0.0009533194480039805 0.10164106586947992 Up 0.05627129283901835 0.10541686984747103 0.05694850857887821 0.009188239973380865 0.018413178473256117 116719 acetyl-CoA carboxylase beta GO:0003989,GO:0005524,GO:0005634,GO:0005739,GO:0006084,GO:0006633,GO:0009374,GO:0010629,GO:0010884,GO:0010906,GO:0014070,GO:0031667,GO:0031999,GO:0042493,GO:0042802,GO:0043086,GO:0046322,GO:0046872,GO:0050995,GO:0051289,GO:0060421,GO:0097009,GO:2001295 acetyl-CoA carboxylase activity|ATP binding|nucleus|mitochondrion|acetyl-CoA metabolic process|fatty acid biosynthetic process|biotin binding|negative regulation of gene expression|positive regulation of lipid storage|regulation of glucose metabolic process|response to organic cyclic compound|response to nutrient levels|negative regulation of fatty acid beta-oxidation|response to drug|identical protein binding|negative regulation of catalytic activity|negative regulation of fatty acid oxidation|metal ion binding|negative regulation of lipid catabolic process|protein homotetramerization|positive regulation of heart growth|energy homeostasis|malonyl-CoA biosynthetic process rno00061,rno00620,rno00640,rno04152,rno04910,rno04920,rno04922,rno04931 Fatty acid biosynthesis|Pyruvate metabolism|Propanoate metabolism|AMPK signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance Acta1 1267.0950293219748 788.6157466419912 1586.0812177752966 2.0111450356639105 1.0080171267392577 2.7052403381337003e-06 0.00118667299746762 Up 35.500840195296256 30.366810818144945 23.57400480804582 15.380509898556756 14.1935482939543 29437 actin, alpha 1, skeletal muscle GO:0001725,GO:0005524,GO:0005737,GO:0005865,GO:0005869,GO:0005884,GO:0009612,GO:0009991,GO:0010226,GO:0010628,GO:0015629,GO:0030017,GO:0030027,GO:0030175,GO:0030240,GO:0043503,GO:0044297,GO:0048545,GO:0048741,GO:0071417,GO:0090131 stress fiber|ATP binding|cytoplasm|striated muscle thin filament|dynactin complex|actin filament|response to mechanical stimulus|response to extracellular stimulus|response to lithium ion|positive regulation of gene expression|actin cytoskeleton|sarcomere|lamellipodium|filopodium|skeletal muscle thin filament assembly|skeletal muscle fiber adaptation|cell body|response to steroid hormone|skeletal muscle fiber development|cellular response to organonitrogen compound|mesenchyme migration Adgra1 3.64218006241244 8.611253660829929 0.32946433013411097 0.04107216211971661 -4.605695294142952 0.013815569497004871 0.4384368863716757 Down 0.00569516269031427 0.0 0.0 0.06974496076856855 0.02911843504038893 309097 GO:0004930,GO:0007186,GO:0014069,GO:0016021,GO:0098978 G protein-coupled receptor activity|G protein-coupled receptor signaling pathway|postsynaptic density|integral component of membrane|glutamatergic synapse Adipoq 20.947056453908765 7.094445725977822 30.18213027252941 4.255887162715544 2.089459900851148 0.0026657223743306144 0.19214476813660997 Up 0.6117684780425549 0.38470946711228704 0.6478463632159132 0.14690061676338714 0.1103954871443824 246253 adiponectin, C1Q and collagen domain containing GO:0001666,GO:0001934,GO:0005102,GO:0005179,GO:0005581,GO:0005615,GO:0005783,GO:0006006,GO:0006635,GO:0007165,GO:0007584,GO:0007623,GO:0009617,GO:0009744,GO:0009749,GO:0009967,GO:0009986,GO:0010467,GO:0010642,GO:0010739,GO:0010745,GO:0010804,GO:0010875,GO:0010906,GO:0014823,GO:0019395,GO:0030336,GO:0030853,GO:0031667,GO:0031953,GO:0032720,GO:0032757,GO:0032869,GO:0032991,GO:0033034,GO:0033691,GO:0034115,GO:0034383,GO:0034612,GO:0035690,GO:0042493,GO:0042593,GO:0042802,GO:0042803,GO:0043123,GO:0043124,GO:0043407,GO:0045471,GO:0045599,GO:0045650,GO:0045721,GO:0045776,GO:0045860,GO:0045892,GO:0045923,GO:0046326,GO:0046888,GO:0048471,GO:0050728,GO:0050731,GO:0050765,GO:0050805,GO:0050873,GO:0051384,GO:0070373,GO:0070543,GO:0070994,GO:0071320,GO:0071639,GO:0071872,GO:0071944,GO:0072659,GO:0090317,GO:0110113,GO:0120162,GO:0120163,GO:1900121,GO:1904706,GO:1904753,GO:1905598,GO:2000279,GO:2000467,GO:2000478,GO:2000481,GO:2000534,GO:2000584,GO:2000590 response to hypoxia|positive regulation of protein phosphorylation|signaling receptor binding|hormone activity|collagen trimer|extracellular space|endoplasmic reticulum|glucose metabolic process|fatty acid beta-oxidation|signal transduction|response to nutrient|circadian rhythm|response to bacterium|response to sucrose|response to glucose|positive regulation of signal transduction|cell surface|gene expression|negative regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of protein kinase A signaling|negative regulation of macrophage derived foam cell differentiation|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cholesterol efflux|regulation of glucose metabolic process|response to activity|fatty acid oxidation|negative regulation of cell migration|negative regulation of granulocyte differentiation|response to nutrient levels|negative regulation of protein autophosphorylation|negative regulation of tumor necrosis factor production|positive regulation of interleukin-8 production|cellular response to insulin stimulus|protein-containing complex|positive regulation of myeloid cell apoptotic process|sialic acid binding|negative regulation of heterotypic cell-cell adhesion|low-density lipoprotein particle clearance|response to tumor necrosis factor|cellular response to drug|response to drug|glucose homeostasis|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of MAP kinase activity|response to ethanol|negative regulation of fat cell differentiation|negative regulation of macrophage differentiation|negative regulation of gluconeogenesis|negative regulation of blood pressure|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|positive regulation of fatty acid metabolic process|positive regulation of glucose import|negative regulation of hormone secretion|perinuclear region of cytoplasm|negative regulation of inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of phagocytosis|negative regulation of synaptic transmission|brown fat cell differentiation|response to glucocorticoid|negative regulation of ERK1 and ERK2 cascade|response to linoleic acid|detection of oxidative stress|cellular response to cAMP|positive regulation of monocyte chemotactic protein-1 production|cellular response to epinephrine stimulus|cell periphery|protein localization to plasma membrane|negative regulation of intracellular protein transport|positive regulation of lipid transporter activity|positive regulation of cold-induced thermogenesis|negative regulation of cold-induced thermogenesis|negative regulation of receptor binding|negative regulation of vascular associated smooth muscle cell proliferation|negative regulation of vascular associated smooth muscle cell migration|negative regulation of low-density lipoprotein receptor activity|negative regulation of DNA biosynthetic process|positive regulation of glycogen (starch) synthase activity|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of cAMP-dependent protein kinase activity|positive regulation of renal albumin absorption|negative regulation of platelet-derived growth factor receptor-alpha signaling pathway|negative regulation of metanephric mesenchymal cell migration rno03320,rno04152,rno04211,rno04920,rno04930,rno04932 PPAR signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Non-alcoholic fatty liver disease Adora1 29.44212037070476 13.678286089296195 39.951343224977116 2.922069983260315 1.5469907309455002 0.014280562196794416 0.4442717171759124 Up 0.10330453405056544 0.17529661628852447 0.31594111486479604 0.09036454100682158 0.04527250120896212 29290 adenosine A1 receptor GO:0000186,GO:0001609,GO:0001659,GO:0001664,GO:0001666,GO:0001883,GO:0001973,GO:0002087,GO:0002674,GO:0002686,GO:0002793,GO:0003084,GO:0003085,GO:0003093,GO:0005515,GO:0005783,GO:0005886,GO:0006612,GO:0007186,GO:0007193,GO:0008285,GO:0010996,GO:0012505,GO:0014050,GO:0014069,GO:0016042,GO:0016323,GO:0030425,GO:0030673,GO:0031072,GO:0031683,GO:0032229,GO:0032244,GO:0032279,GO:0032795,GO:0032900,GO:0035307,GO:0035814,GO:0042310,GO:0042311,GO:0042321,GO:0042323,GO:0042734,GO:0043025,GO:0043066,GO:0043195,GO:0043197,GO:0043268,GO:0044297,GO:0044305,GO:0044877,GO:0045202,GO:0045211,GO:0045741,GO:0045776,GO:0045777,GO:0045822,GO:0046888,GO:0046982,GO:0048786,GO:0050728,GO:0050890,GO:0050965,GO:0050995,GO:0050996,GO:0051930,GO:0051967,GO:0055089,GO:0055117,GO:0060079,GO:0060087,GO:0070256,GO:0070328,GO:0086004,GO:0099055,GO:0099056,GO:0099509,GO:0099582,GO:1900272,GO:1900453,GO:1901216 activation of MAPKK activity|G protein-coupled adenosine receptor activity|temperature homeostasis|G protein-coupled receptor binding|response to hypoxia|purine nucleoside binding|G protein-coupled adenosine receptor signaling pathway|regulation of respiratory gaseous exchange by nervous system process|negative regulation of acute inflammatory response|negative regulation of leukocyte migration|positive regulation of peptide secretion|positive regulation of systemic arterial blood pressure|negative regulation of systemic arterial blood pressure|regulation of glomerular filtration|protein binding|endoplasmic reticulum|plasma membrane|protein targeting to membrane|G protein-coupled receptor signaling pathway|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|negative regulation of cell population proliferation|response to auditory stimulus|endomembrane system|negative regulation of glutamate secretion|postsynaptic density|lipid catabolic process|basolateral plasma membrane|dendrite|axolemma|heat shock protein binding|G-protein beta/gamma-subunit complex binding|negative regulation of synaptic transmission, GABAergic|positive regulation of nucleoside transport|asymmetric synapse|heterotrimeric G-protein binding|negative regulation of neurotrophin production|positive regulation of protein dephosphorylation|negative regulation of renal sodium excretion|vasoconstriction|vasodilation|negative regulation of circadian sleep/wake cycle, sleep|negative regulation of circadian sleep/wake cycle, non-REM sleep|presynaptic membrane|neuronal cell body|negative regulation of apoptotic process|terminal bouton|dendritic spine|positive regulation of potassium ion transport|cell body|calyx of Held|protein-containing complex binding|synapse|postsynaptic membrane|positive regulation of epidermal growth factor-activated receptor activity|negative regulation of blood pressure|positive regulation of blood pressure|negative regulation of heart contraction|negative regulation of hormone secretion|protein heterodimerization activity|presynaptic active zone|negative regulation of inflammatory response|cognition|detection of temperature stimulus involved in sensory perception of pain|negative regulation of lipid catabolic process|positive regulation of lipid catabolic process|regulation of sensory perception of pain|negative regulation of synaptic transmission, glutamatergic|fatty acid homeostasis|regulation of cardiac muscle contraction|excitatory postsynaptic potential|relaxation of vascular associated smooth muscle|negative regulation of mucus secretion|triglyceride homeostasis|regulation of cardiac muscle cell contraction|integral component of postsynaptic membrane|integral component of presynaptic membrane|regulation of presynaptic cytosolic calcium ion concentration|neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration|negative regulation of long-term synaptic potentiation|negative regulation of long-term synaptic depression|positive regulation of neuron death rno04022,rno04024,rno04071,rno04080,rno04923,rno04924,rno05032 cGMP-PKG signaling pathway|cAMP signaling pathway|Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction|Regulation of lipolysis in adipocytes|Renin secretion|Morphine addiction Aim2 5.926300013069099 1.013706648755778 9.201362255944645 9.078639893686317 3.182476177955585 0.03010286066618604 0.5835469947070129 Up 0.014283765985815343 0.02423800531296085 0.027799362993304568 0.002429500146000052 0.0024343519498131005 304987 GO:0002218,GO:0002230,GO:0003690,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0032088,GO:0032731,GO:0033209,GO:0035458,GO:0035690,GO:0042802,GO:0044546,GO:0051092,GO:0070269,GO:0097169,GO:1904270,GO:2001056 activation of innate immune response|positive regulation of defense response to virus by host|double-stranded DNA binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta production|tumor necrosis factor-mediated signaling pathway|cellular response to interferon-beta|cellular response to drug|identical protein binding|NLRP3 inflammasome complex assembly|positive regulation of NF-kappaB transcription factor activity|pyroptosis|AIM2 inflammasome complex|pyroptosome complex assembly|positive regulation of cysteine-type endopeptidase activity rno04621,rno04623 NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway Aldh1a3 12.842224779482539 22.80614837403607 6.199609049780183 0.2724707943387508 -1.8758264966335785 0.04578111857640002 0.6643454759011997 Down 0.07403396325151201 0.0 0.06483889886865317 0.18132917857815994 0.1589798873389425 266603 aldehyde dehydrogenase 1 family, member A3 GO:0001758,GO:0001822,GO:0002072,GO:0002138,GO:0004029,GO:0004030,GO:0005737,GO:0005829,GO:0007626,GO:0021768,GO:0021983,GO:0031076,GO:0042472,GO:0042493,GO:0042572,GO:0042573,GO:0042574,GO:0042803,GO:0043065,GO:0043584,GO:0048048,GO:0050885,GO:0051289,GO:0060013,GO:0060166,GO:0060324,GO:0070324,GO:0070384,GO:0070403 retinal dehydrogenase activity|kidney development|optic cup morphogenesis involved in camera-type eye development|retinoic acid biosynthetic process|aldehyde dehydrogenase (NAD+) activity|aldehyde dehydrogenase [NAD(P)+] activity|cytoplasm|cytosol|locomotory behavior|nucleus accumbens development|pituitary gland development|embryonic camera-type eye development|inner ear morphogenesis|response to drug|retinol metabolic process|retinoic acid metabolic process|retinal metabolic process|protein homodimerization activity|positive regulation of apoptotic process|nose development|embryonic eye morphogenesis|neuromuscular process controlling balance|protein homotetramerization|righting reflex|olfactory pit development|face development|thyroid hormone binding|Harderian gland development|NAD+ binding rno00830 Retinol metabolism Alpk3 37.32058466390188 20.265128083239816 48.69088905100993 2.4005453485292705 1.2633621901020375 0.0271757684829097 0.5612610958154545 Up 0.260708748619396 0.3799388373137713 0.1144130036887061 0.1356388910323384 0.07318218224976923 365298 alpha-kinase 3 GO:0004674,GO:0005524,GO:0005634,GO:0006468,GO:0007507,GO:0055007,GO:0055013 protein serine/threonine kinase activity|ATP binding|nucleus|protein phosphorylation|heart development|cardiac muscle cell differentiation|cardiac muscle cell development Ampd1 51.351730096160004 31.926506582212824 64.3018791054581 2.0132501060123147 1.009526409363072 0.016517235946769446 0.4627538749831228 Up 0.4431131942147156 0.4095958809795887 0.2836829380781489 0.2082545924888452 0.1669363878384363 25028 adenosine monophosphate deaminase 1 GO:0003876,GO:0005829,GO:0006188,GO:0010033,GO:0032036,GO:0032264,GO:0042802,GO:0046033,GO:0046872 AMP deaminase activity|cytosol|IMP biosynthetic process|response to organic substance|myosin heavy chain binding|IMP salvage|identical protein binding|AMP metabolic process|metal ion binding rno00230 Purine metabolism Ankrd63 7.333022183427997 1.5213103807899788 11.207496718520007 7.367042467947912 2.881085559187841 0.022491659949716285 0.5211209249996686 Up 0.047645997006701225 0.07546009465716537 0.05666810855261924 0.00540268146832105 0.010826941655698237 691770 Anxa8 42.34639688490049 62.846810592232984 28.67945441334549 0.4561022665566626 -1.1325707553386315 0.009944341617217493 0.3806690116633436 Down 0.39126869972012 0.35149798930628 0.2575645855082528 0.7516256933407541 0.7060562984245017 306283 annexin A8 GO:0005509,GO:0005544,GO:0005546,GO:0005547,GO:0005737,GO:0005829,GO:0005886,GO:0007032,GO:0007596,GO:0016197,GO:0031902,GO:0043325,GO:0051015,GO:1900004,GO:1900138 calcium ion binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|cytosol|plasma membrane|endosome organization|blood coagulation|endosomal transport|late endosome membrane|phosphatidylinositol-3,4-bisphosphate binding|actin filament binding|negative regulation of serine-type endopeptidase activity|negative regulation of phospholipase A2 activity Apobec1 20.039495844986185 10.643169404279355 26.303713472124066 2.4716827683730145 1.3054935903847371 0.045556266560955634 0.662334621695409 Up 0.11806232462921762 0.13022034352861814 0.14360959766581638 0.0552227750597243 0.05030277912106902 25383 apolipoprotein B mRNA editing enzyme catalytic subunit 1 GO:0003723,GO:0003729,GO:0004126,GO:0004131,GO:0005515,GO:0005634,GO:0005737,GO:0006397,GO:0006641,GO:0006970,GO:0008047,GO:0008270,GO:0009972,GO:0010043,GO:0010332,GO:0016554,GO:0016556,GO:0019904,GO:0032869,GO:0035925,GO:0042127,GO:0042157,GO:0042158,GO:0042493,GO:0042953,GO:0043021,GO:0045471,GO:0046087,GO:0048255,GO:0051592,GO:0051607,GO:0070383,GO:0080111,GO:0090209,GO:0090310,GO:0090366 RNA binding|mRNA binding|cytidine deaminase activity|cytosine deaminase activity|protein binding|nucleus|cytoplasm|mRNA processing|triglyceride metabolic process|response to osmotic stress|enzyme activator activity|zinc ion binding|cytidine deamination|response to zinc ion|response to gamma radiation|cytidine to uridine editing|mRNA modification|protein domain specific binding|cellular response to insulin stimulus|mRNA 3'-UTR AU-rich region binding|regulation of cell population proliferation|lipoprotein metabolic process|lipoprotein biosynthetic process|response to drug|lipoprotein transport|ribonucleoprotein complex binding|response to ethanol|cytidine metabolic process|mRNA stabilization|response to calcium ion|defense response to virus|DNA cytosine deamination|DNA demethylation|negative regulation of triglyceride metabolic process|negative regulation of DNA methylation-dependent heterochromatin assembly|positive regulation of mRNA modification Arhgef39 20.59598363159804 6.077737446596798 30.274814421598855 4.979494114367792 2.315999180894737 0.0016220136305678482 0.14149304130743282 Up 0.36312722703277095 0.5881790845115882 0.5621682307146441 0.1516017083701735 0.050634820907987856 298404 Rho guanine nucleotide exchange factor 39 GO:0005085,GO:0005886,GO:0030335,GO:0050790 guanyl-nucleotide exchange factor activity|plasma membrane|positive regulation of cell migration|regulation of catalytic activity Armh1 8.861434301703609 18.260227015417613 2.5955724925609385 0.1429530217659992 -2.8063869786557025 0.014333319745030838 0.4443090738628346 Down 0.014749655082192085 0.0 0.043059129090649136 0.06773604445095129 0.2036139476920162 500531 armadillo-like helical domain containing 1 Asphd1 18.23651196963144 5.067032428466266 27.01616499707488 5.32994610641859 2.414120945292945 0.0015948383576628133 0.13991744745826953 Up 0.4594443064895349 0.3577113376020981 0.2892935561868057 0.08274288527543812 0.055272083967574624 293498 GO:0016021,GO:0018193,GO:0051213 integral component of membrane|peptidyl-amino acid modification|dioxygenase activity Bcam 126.19424430675915 73.00338767885485 161.6548153920286 2.214301042595073 1.146851375296722 3.318073891437897e-05 0.008086093405594609 Up 2.132303676129772 1.7898980909460316 1.6334845987317723 0.7060679442961296 0.9626339846578226 78958 basal cell adhesion molecule (Lutheran blood group) GO:0005055,GO:0005886,GO:0007155,GO:0007160,GO:0008022,GO:0009986,GO:0016021,GO:0043236 laminin receptor activity|plasma membrane|cell adhesion|cell-matrix adhesion|protein C-terminus binding|cell surface|integral component of membrane|laminin binding Bche 3.6402158862320313 8.103649928795729 0.6645931911895654 0.0815422740181214 -3.616307999088556 0.03827674968897499 0.63063538773659 Down 0.014247004429763812 0.014505374958060013 0.0 0.1744738155967705 0.05827408213833745 65036 butyrylcholinesterase GO:0003990,GO:0004104,GO:0005615,GO:0005641,GO:0005783,GO:0005788,GO:0007584,GO:0007612,GO:0008285,GO:0014016,GO:0016020,GO:0019695,GO:0033265,GO:0042493,GO:0042802,GO:0043279,GO:0050805,GO:0051384,GO:0051593 acetylcholinesterase activity|cholinesterase activity|extracellular space|nuclear envelope lumen|endoplasmic reticulum|endoplasmic reticulum lumen|response to nutrient|learning|negative regulation of cell population proliferation|neuroblast differentiation|membrane|choline metabolic process|choline binding|response to drug|identical protein binding|response to alkaloid|negative regulation of synaptic transmission|response to glucocorticoid|response to folic acid Bdkrb1 18.802554522498696 8.618757737393048 25.59175237923579 2.9710072532746055 1.5709521273041014 0.02465022648413184 0.5428977043037786 Up 0.2839656472545613 0.20345156810278986 0.3275021390794026 0.07513210101661245 0.10754591809728553 81509 bradykinin receptor B1 GO:0001933,GO:0002687,GO:0004930,GO:0004947,GO:0005886,GO:0006954,GO:0007186,GO:0007205,GO:0009612,GO:0016020,GO:0016021,GO:0016477,GO:0019233,GO:0019371,GO:0030308,GO:0032496,GO:0042277,GO:0043005,GO:0045776,GO:0051281,GO:0060085 negative regulation of protein phosphorylation|positive regulation of leukocyte migration|G protein-coupled receptor activity|bradykinin receptor activity|plasma membrane|inflammatory response|G protein-coupled receptor signaling pathway|protein kinase C-activating G protein-coupled receptor signaling pathway|response to mechanical stimulus|membrane|integral component of membrane|cell migration|sensory perception of pain|cyclooxygenase pathway|negative regulation of cell growth|response to lipopolysaccharide|peptide binding|neuron projection|negative regulation of blood pressure|positive regulation of release of sequestered calcium ion into cytosol|smooth muscle relaxation of the bladder outlet rno04020,rno04080,rno04610,rno04750,rno04810,rno05200 Calcium signaling pathway|Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Pathways in cancer C17h6orf52 38.19003579705418 21.79244172528029 49.12176517823677 2.2532543503763134 1.1720101761187782 0.014294940942154674 0.4442717171759124 Up 0.5637211132388638 0.5739442392691306 0.4165014523329352 0.2450325787126709 0.2134973200464256 498729 similar to human chromosome 6 open reading frame 52 C1qb 2.6389390804527944 6.597347701131985 0.0 0.02752852517252996 -5.182928869462469 0.0198212612893714 0.498325653862447 Down 0.0 0.0 0.0 0.025329454676154533 0.3045604626784724 29687 complement C1q B chain GO:0005576,GO:0005581,GO:0005602,GO:0006955,GO:0006958,GO:0007420,GO:0007568,GO:0010033,GO:0042802,GO:0045087,GO:0045202,GO:0048839,GO:0051384,GO:0098794,GO:0098883 extracellular region|collagen trimer|complement component C1 complex|immune response|complement activation, classical pathway|brain development|aging|response to organic substance|identical protein binding|innate immune response|synapse|inner ear development|response to glucocorticoid|postsynapse|synapse pruning rno04610,rno05020,rno05133,rno05142,rno05150,rno05171,rno05322 Complement and coagulation cascades|Prion disease|Pertussis|Chagas disease|Staphylococcus aureus infection|Coronavirus disease - COVID-19|Systemic lupus erythematosus Camp 9.308780721411509 1.013706648755778 14.838830103181989 14.633587485966098 3.8712115905253928 0.00371926334200461 0.23529505227525205 Up 0.4565848859914069 0.9297301764927202 0.66646126425288 0.04659582276603171 0.04668887638899222 316010 cathelicidin antimicrobial peptide GO:0001530,GO:0001878,GO:0001934,GO:0002227,GO:0002544,GO:0005615,GO:0005737,GO:0008284,GO:0019731,GO:0019732,GO:0032757,GO:0035821,GO:0042581,GO:0042742,GO:0042995,GO:0045087,GO:0045766,GO:0050829,GO:0050830,GO:0051838,GO:0051873,GO:0061844,GO:0071222,GO:0071224,GO:0071347,GO:0071354,GO:0071356 lipopolysaccharide binding|response to yeast|positive regulation of protein phosphorylation|innate immune response in mucosa|chronic inflammatory response|extracellular space|cytoplasm|positive regulation of cell population proliferation|antibacterial humoral response|antifungal humoral response|positive regulation of interleukin-8 production|modulation of process of other organism|specific granule|defense response to bacterium|cell projection|innate immune response|positive regulation of angiogenesis|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|cytolysis by host of symbiont cells|killing by host of symbiont cells|antimicrobial humoral immune response mediated by antimicrobial peptide|cellular response to lipopolysaccharide|cellular response to peptidoglycan|cellular response to interleukin-1|cellular response to interleukin-6|cellular response to tumor necrosis factor rno04613,rno04621,rno04970,rno05150,rno05152 Neutrophil extracellular trap formation|NOD-like receptor signaling pathway|Salivary secretion|Staphylococcus aureus infection|Tuberculosis Capn8 2.2328560948254337 5.5821402370635855 0.0 0.032535086758069175 -4.941859788947354 0.034669211962040744 0.6092043700399861 Down 0.0 0.0 0.0 0.006429279995501433 0.0644211951117246 170808 calpain 8 GO:0004198,GO:0005509,GO:0005737,GO:0005794,GO:0006508,GO:0007586,GO:0042802,GO:1990092 calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|cytoplasm|Golgi apparatus|proteolysis|digestion|identical protein binding|calcium-dependent self proteolysis Ccdc116 3.4401760240435983 7.603550273324647 0.6645931911895654 0.0869129209287553 -3.524285518211009 0.0437269912472556 0.6517868899214712 Down 0.006196358110026968 0.00630872954405667 0.0 0.04426495252113527 0.05068954435192115 287936 coiled-coil domain containing 116 GO:0005737,GO:0005813 cytoplasm|centrosome Ccdc177 9.848835659759253 18.239215601040886 4.2552490322381615 0.2337244813904182 -2.0971192382559773 0.03249588623933604 0.5959266279603633 Down 0.018104506547479467 0.002633261882188178 0.012584059959793384 0.06070744313587002 0.03438142680824965 500686 Ccl17 2.752380247081004 0.0 4.587300411801672 24.61378153627275 4.621394418043881 0.037805448018374335 0.627488695595785 Up 0.09487898694715052 0.4829981236034876 0.7386218455833337 0.0 0.0 117518 C-C motif chemokine ligand 17 GO:0002548,GO:0005615,GO:0006954,GO:0007186,GO:0008009,GO:0030593,GO:0031640,GO:0031729,GO:0043547,GO:0045662,GO:0048020,GO:0048247,GO:0061844,GO:0070098,GO:0070374,GO:0071346,GO:0071347,GO:0071356 monocyte chemotaxis|extracellular space|inflammatory response|G protein-coupled receptor signaling pathway|chemokine activity|neutrophil chemotaxis|killing of cells of other organism|CCR4 chemokine receptor binding|positive regulation of GTPase activity|negative regulation of myoblast differentiation|CCR chemokine receptor binding|lymphocyte chemotaxis|antimicrobial humoral immune response mediated by antimicrobial peptide|chemokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor rno04060,rno04061,rno04062,rno04625,rno04657 Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|Chemokine signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway Cd4 25.3429419142629 45.113697907913675 12.162437918495714 0.2696878478271302 -1.8906375798934671 0.0013871630985191512 0.1306571475556106 Down 0.05718812831562599 0.11645047889994314 0.12720083081190844 0.3501729434862817 0.3926427583223278 24932 Cd4 molecule GO:0001934,GO:0002250,GO:0005102,GO:0005788,GO:0005789,GO:0005886,GO:0005887,GO:0006948,GO:0007155,GO:0007166,GO:0008270,GO:0009897,GO:0009986,GO:0010524,GO:0015026,GO:0019865,GO:0019899,GO:0019901,GO:0023026,GO:0030217,GO:0030225,GO:0032355,GO:0032507,GO:0033280,GO:0033674,GO:0035397,GO:0035723,GO:0042011,GO:0042012,GO:0042102,GO:0042110,GO:0042289,GO:0042802,GO:0042803,GO:0043123,GO:0043410,GO:0045058,GO:0045121,GO:0045657,GO:0045860,GO:0045893,GO:0046598,GO:0050731,GO:0050829,GO:0050850,GO:0050863,GO:0050870,GO:0051924,GO:0070374,GO:0097011,GO:1990782 positive regulation of protein phosphorylation|adaptive immune response|signaling receptor binding|endoplasmic reticulum lumen|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|induction by virus of host cell-cell fusion|cell adhesion|cell surface receptor signaling pathway|zinc ion binding|external side of plasma membrane|cell surface|positive regulation of calcium ion transport into cytosol|coreceptor activity|immunoglobulin binding|enzyme binding|protein kinase binding|MHC class II protein complex binding|T cell differentiation|macrophage differentiation|response to estradiol|maintenance of protein location in cell|response to vitamin D|positive regulation of kinase activity|helper T cell enhancement of adaptive immune response|interleukin-15-mediated signaling pathway|interleukin-16 binding|interleukin-16 receptor activity|positive regulation of T cell proliferation|T cell activation|MHC class II protein binding|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|T cell selection|membrane raft|positive regulation of monocyte differentiation|positive regulation of protein kinase activity|positive regulation of transcription, DNA-templated|positive regulation of viral entry into host cell|positive regulation of peptidyl-tyrosine phosphorylation|defense response to Gram-negative bacterium|positive regulation of calcium-mediated signaling|regulation of T cell activation|positive regulation of T cell activation|regulation of calcium ion transport|positive regulation of ERK1 and ERK2 cascade|cellular response to granulocyte macrophage colony-stimulating factor stimulus|protein tyrosine kinase binding rno04060,rno04514,rno04612,rno04640,rno04658,rno04659,rno04660,rno05135,rno05166,rno05170,rno05235,rno05340 Cytokine-cytokine receptor interaction|Cell adhesion molecules|Antigen processing and presentation|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Yersinia infection|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection|PD-L1 expression and PD-1 checkpoint pathway in cancer|Primary immunodeficiency Cdca7 16.537426449488475 6.589843624568868 23.169148332768213 3.513036484912517 1.8127185598591808 0.02168096896337492 0.5151943733580973 Up 0.2868339871258195 0.3854871816684439 0.13397814780521014 0.07025339315839088 0.08212597381974532 311742 cell division cycle associated 7 GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006915,GO:0042127 nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|apoptotic process|regulation of cell population proliferation Cdh18 36.59561237286577 19.26042632635978 48.15240307053642 2.501609564122396 1.32285664007977 0.014843761393394984 0.45064809393255195 Up 0.2734307812807645 0.10953028314787752 0.27044028204429144 0.08691537789864251 0.08708895120037516 310174 cadherin 18 GO:0000902,GO:0005509,GO:0005912,GO:0007043,GO:0007156,GO:0007275,GO:0016021,GO:0016339,GO:0016342,GO:0034332,GO:0045296,GO:0098742 cell morphogenesis|calcium ion binding|adherens junction|cell-cell junction assembly|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|adherens junction organization|cadherin binding|cell-cell adhesion via plasma-membrane adhesion molecules Cecr2 5.694207112764465 0.5076037320342007 9.151942699917967 18.068416974615317 4.175398208012107 0.022675376312257096 0.5212077730306993 Up 0.033662244897164746 0.034272712314409766 0.08735221658817366 0.0 0.005736985020748467 500308 CECR2, histone acetyl-lysine reader GO:0000791,GO:0001842,GO:0001843,GO:0005634,GO:0007338,GO:0021915,GO:0031010,GO:0043044,GO:0060122,GO:0090102,GO:0090537,GO:0097194 euchromatin|neural fold formation|neural tube closure|nucleus|single fertilization|neural tube development|ISWI-type complex|ATP-dependent chromatin remodeling|inner ear receptor cell stereocilium organization|cochlea development|CERF complex|execution phase of apoptosis Cend1 9.04721710999236 16.72240766618878 3.9304234058614127 0.23544647402440802 -2.0865289774552336 0.030978869221805518 0.59089296783491 Down 0.047467547579709835 0.04832837522986996 0.09238233018384097 0.3067994622572425 0.2265142175607878 361675 cell cycle exit and neuronal differentiation 1 GO:0005739,GO:0007628,GO:0016021,GO:0021686,GO:0021702,GO:0021933,GO:0021941,GO:0030182,GO:0031982 mitochondrion|adult walking behavior|integral component of membrane|cerebellar granular layer maturation|cerebellar Purkinje cell differentiation|radial glia guided migration of cerebellar granule cell|negative regulation of cerebellar granule cell precursor proliferation|neuron differentiation|vesicle Cfap91 2.778017765845813 0.0 4.630029609743019 24.81784627969911 4.633306017107642 0.04949351711943493 0.6853658499050183 Up 0.0 0.04882888817787897 0.025927524454105268 0.0 0.0 303920 Chi3l1 42.53761102824143 26.35337123702498 53.327104222385714 2.0233145593679547 1.0167206293187427 0.022435706395851976 0.5211209249996686 Up 0.7288773934827635 0.8966989000747608 0.8274912163345634 0.4339070714784611 0.3726630860015815 89824 chitinase 3 like 1 GO:0004568,GO:0005576,GO:0005615,GO:0005737,GO:0005783,GO:0005975,GO:0006032,GO:0006915,GO:0006954,GO:0007250,GO:0008061,GO:0009612,GO:0010800,GO:0030246,GO:0030324,GO:0032757,GO:0034612,GO:0045766,GO:0048471,GO:0051897,GO:0070374,GO:0070555,GO:0070741,GO:0071347,GO:0071356 chitinase activity|extracellular region|extracellular space|cytoplasm|endoplasmic reticulum|carbohydrate metabolic process|chitin catabolic process|apoptotic process|inflammatory response|activation of NF-kappaB-inducing kinase activity|chitin binding|response to mechanical stimulus|positive regulation of peptidyl-threonine phosphorylation|carbohydrate binding|lung development|positive regulation of interleukin-8 production|response to tumor necrosis factor|positive regulation of angiogenesis|perinuclear region of cytoplasm|positive regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade|response to interleukin-1|response to interleukin-6|cellular response to interleukin-1|cellular response to tumor necrosis factor Chrna1 111.55603969915798 49.698640464660336 152.79430585548968 3.0739101359103995 1.6200749892409567 2.567644613342833e-06 0.0011594425808427213 Up 2.1404699455277156 2.8124589117330863 1.745143830835001 0.4575457926312066 0.9908641431268176 79557 cholinergic receptor nicotinic alpha 1 subunit GO:0003009,GO:0005886,GO:0005887,GO:0005892,GO:0006812,GO:0007165,GO:0007268,GO:0007271,GO:0007274,GO:0007528,GO:0009986,GO:0015464,GO:0016020,GO:0019228,GO:0022848,GO:0030594,GO:0031594,GO:0034220,GO:0042166,GO:0042391,GO:0043005,GO:0045202,GO:0046716,GO:0048630,GO:0050877,GO:0050881,GO:0050905,GO:0060079,GO:0070050,GO:0099060,GO:1904315 skeletal muscle contraction|plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|cation transport|signal transduction|chemical synaptic transmission|synaptic transmission, cholinergic|neuromuscular synaptic transmission|neuromuscular junction development|cell surface|acetylcholine receptor activity|membrane|neuronal action potential|acetylcholine-gated cation-selective channel activity|neurotransmitter receptor activity|neuromuscular junction|ion transmembrane transport|acetylcholine binding|regulation of membrane potential|neuron projection|synapse|muscle cell cellular homeostasis|skeletal muscle tissue growth|nervous system process|musculoskeletal movement|neuromuscular process|excitatory postsynaptic potential|neuron cellular homeostasis|integral component of postsynaptic specialization membrane|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential rno04080 Neuroactive ligand-receptor interaction Chrnd 112.13660953211692 55.23425542703259 150.07151226883983 2.7167376533874714 1.4418752558687231 1.7367356062471916e-06 0.0008888033920904377 Up 2.9027599497132925 2.152303430982145 2.118529462169886 1.0142833637242683 0.7420668348712701 54240 cholinergic receptor nicotinic delta subunit GO:0003009,GO:0004888,GO:0005654,GO:0005829,GO:0005886,GO:0005887,GO:0005892,GO:0006812,GO:0007165,GO:0007268,GO:0015276,GO:0022848,GO:0030594,GO:0031594,GO:0034220,GO:0042166,GO:0042391,GO:0043005,GO:0045202,GO:0048630,GO:0050877,GO:0050881,GO:0060079,GO:0099060,GO:1904315 skeletal muscle contraction|transmembrane signaling receptor activity|nucleoplasm|cytosol|plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|cation transport|signal transduction|chemical synaptic transmission|ligand-gated ion channel activity|acetylcholine-gated cation-selective channel activity|neurotransmitter receptor activity|neuromuscular junction|ion transmembrane transport|acetylcholine binding|regulation of membrane potential|neuron projection|synapse|skeletal muscle tissue growth|nervous system process|musculoskeletal movement|excitatory postsynaptic potential|integral component of postsynaptic specialization membrane|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential rno04080 Neuroactive ligand-receptor interaction Chrng 135.1263415706646 82.61183902000171 170.13600993777314 2.059381263325351 1.042210947886241 3.2216303799659526e-05 0.007977692132841495 Up 2.6434570151509043 2.4683524194461204 2.416043345883257 1.26688751745417 1.1648772718275415 25753 cholinergic receptor nicotinic gamma subunit GO:0003009,GO:0004888,GO:0005886,GO:0005887,GO:0005892,GO:0006812,GO:0007165,GO:0007268,GO:0015276,GO:0022848,GO:0030594,GO:0034220,GO:0042391,GO:0043005,GO:0045202,GO:0045211,GO:0050877,GO:0060079 skeletal muscle contraction|transmembrane signaling receptor activity|plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|cation transport|signal transduction|chemical synaptic transmission|ligand-gated ion channel activity|acetylcholine-gated cation-selective channel activity|neurotransmitter receptor activity|ion transmembrane transport|regulation of membrane potential|neuron projection|synapse|postsynaptic membrane|nervous system process|excitatory postsynaptic potential rno04080 Neuroactive ligand-receptor interaction Cip2a 31.33830544427657 18.25122212354187 40.06302765809968 2.1960034019530026 1.1348802893052812 0.0328854745180058 0.5962441315531235 Up 0.1441222634425347 0.1596832199517994 0.21037031414724933 0.06488866953634645 0.09102555653405232 360711 GO:0005737,GO:0005829,GO:0005886,GO:0007283,GO:0042803,GO:2000179 cytoplasm|cytosol|plasma membrane|spermatogenesis|protein homodimerization activity|positive regulation of neural precursor cell proliferation Clcn4 26.75257710728709 49.150514719185324 11.820618699354934 0.2406606956352456 -2.0549275527521043 0.0006052076890682808 0.07193894872004239 Down 0.035555979161589965 0.078435044125377 0.09803303232908364 0.3507638591742826 0.2363294753032177 60586 chloride voltage-gated channel 4 GO:0005247,GO:0005254,GO:0005524,GO:0005765,GO:0005769,GO:0005789,GO:0005794,GO:0005887,GO:0006821,GO:0008021,GO:0010008,GO:0015297,GO:0015299,GO:0016021,GO:0031901,GO:0031902,GO:0034220,GO:0055037,GO:0055038,GO:0097546,GO:1902600,GO:1905515 voltage-gated chloride channel activity|chloride channel activity|ATP binding|lysosomal membrane|early endosome|endoplasmic reticulum membrane|Golgi apparatus|integral component of plasma membrane|chloride transport|synaptic vesicle|endosome membrane|antiporter activity|solute:proton antiporter activity|integral component of membrane|early endosome membrane|late endosome membrane|ion transmembrane transport|recycling endosome|recycling endosome membrane|ciliary base|proton transmembrane transport|non-motile cilium assembly rno04613 Neutrophil extracellular trap formation Col26a1 21.66626051426586 34.969127343792785 12.797682627914586 0.36627865951870586 -1.4489864470852534 0.018034453337048898 0.4798064527424439 Down 0.12685974892675034 0.12916036029465675 0.19078411248526408 0.43547009879874987 0.3773749181234405 685612 collagen type XXVI alpha 1 chain GO:0005783,GO:0005794,GO:0010811,GO:0031012 endoplasmic reticulum|Golgi apparatus|positive regulation of cell-substrate adhesion|extracellular matrix rno04974 Protein digestion and absorption Colec10 31.931511479050545 14.694994368677225 43.42252288596608 2.954770682922141 1.5630461684912769 0.0034192531021674864 0.22434099520332232 Up 0.2330651073092025 0.18508757363732253 0.1950463523419753 0.08086891749045434 0.057197940551810676 299928 collectin subfamily member 10 GO:0005537,GO:0005581,GO:0005615,GO:0005737,GO:0042056,GO:0050918,GO:1904888 mannose binding|collagen trimer|extracellular space|cytoplasm|chemoattractant activity|positive chemotaxis|cranial skeletal system development Csf1r 23.722639045199863 41.56797586023739 11.825747835174846 0.284662854570032 -1.8126738456564355 0.00260276966460801 0.1884920880222961 Down 0.10388109417751593 0.05288249293130153 0.07581583127438732 0.2451566680934481 0.2987589590821948 307403 colony stimulating factor 1 receptor GO:0001934,GO:0002244,GO:0002931,GO:0004714,GO:0005011,GO:0005524,GO:0005654,GO:0005886,GO:0005887,GO:0006954,GO:0007169,GO:0007275,GO:0007411,GO:0007519,GO:0008283,GO:0008284,GO:0008285,GO:0008360,GO:0009986,GO:0010759,GO:0014005,GO:0016020,GO:0016021,GO:0018108,GO:0019221,GO:0019903,GO:0019955,GO:0021542,GO:0021772,GO:0021879,GO:0030097,GO:0030316,GO:0030335,GO:0031529,GO:0032722,GO:0032944,GO:0033674,GO:0036006,GO:0038145,GO:0042531,GO:0042803,GO:0043066,GO:0043231,GO:0043235,GO:0044794,GO:0045087,GO:0045124,GO:0045217,GO:0045672,GO:0046488,GO:0046777,GO:0048015,GO:0061098,GO:0061518,GO:0070374,GO:0071345,GO:0071902,GO:0120041,GO:1990138,GO:1990682,GO:2000147,GO:2000249 positive regulation of protein phosphorylation|hematopoietic progenitor cell differentiation|response to ischemia|transmembrane receptor protein tyrosine kinase activity|macrophage colony-stimulating factor receptor activity|ATP binding|nucleoplasm|plasma membrane|integral component of plasma membrane|inflammatory response|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|axon guidance|skeletal muscle tissue development|cell population proliferation|positive regulation of cell population proliferation|negative regulation of cell population proliferation|regulation of cell shape|cell surface|positive regulation of macrophage chemotaxis|microglia development|membrane|integral component of membrane|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|protein phosphatase binding|cytokine binding|dentate gyrus development|olfactory bulb development|forebrain neuron differentiation|hemopoiesis|osteoclast differentiation|positive regulation of cell migration|ruffle organization|positive regulation of chemokine production|regulation of mononuclear cell proliferation|positive regulation of kinase activity|cellular response to macrophage colony-stimulating factor stimulus|macrophage colony-stimulating factor signaling pathway|positive regulation of tyrosine phosphorylation of STAT protein|protein homodimerization activity|negative regulation of apoptotic process|intracellular membrane-bounded organelle|receptor complex|positive regulation by host of viral process|innate immune response|regulation of bone resorption|cell-cell junction maintenance|positive regulation of osteoclast differentiation|phosphatidylinositol metabolic process|protein autophosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein tyrosine kinase activity|microglial cell proliferation|positive regulation of ERK1 and ERK2 cascade|cellular response to cytokine stimulus|positive regulation of protein serine/threonine kinase activity|positive regulation of macrophage proliferation|neuron projection extension|CSF1-CSF1R complex|positive regulation of cell motility|regulation of actin cytoskeleton reorganization rno04010,rno04014,rno04015,rno04060,rno04061,rno04151,rno04380,rno04640,rno05200,rno05202,rno05221 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Cytokine-cytokine receptor interaction|Viral protein interaction with cytokine and cytokine receptor|PI3K-Akt signaling pathway|Osteoclast differentiation|Hematopoietic cell lineage|Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia Csrp3 27.969828364345002 10.149073010058768 39.85033193386914 3.9274376213891715 1.973588361699696 0.01262989019011798 0.4173178277223848 Up 2.3015805865889414 0.61512148128599 0.5599230119744626 0.05872075729224643 0.5295422238183762 117505 cysteine and glycine rich protein 3 GO:0001974,GO:0002026,GO:0003300,GO:0003779,GO:0005515,GO:0005634,GO:0005737,GO:0005856,GO:0006874,GO:0006954,GO:0007507,GO:0007517,GO:0008286,GO:0008307,GO:0030018,GO:0030036,GO:0031433,GO:0033292,GO:0033365,GO:0035995,GO:0042593,GO:0042802,GO:0042805,GO:0045214,GO:0045662,GO:0045663,GO:0045944,GO:0046872,GO:0048738,GO:0055003,GO:0060048,GO:0060537,GO:0070528,GO:1903076,GO:1903919,GO:1903920 blood vessel remodeling|regulation of the force of heart contraction|cardiac muscle hypertrophy|actin binding|protein binding|nucleus|cytoplasm|cytoskeleton|cellular calcium ion homeostasis|inflammatory response|heart development|muscle organ development|insulin receptor signaling pathway|structural constituent of muscle|Z disc|actin cytoskeleton organization|telethonin binding|T-tubule organization|protein localization to organelle|detection of muscle stretch|glucose homeostasis|identical protein binding|actinin binding|sarcomere organization|negative regulation of myoblast differentiation|positive regulation of myoblast differentiation|positive regulation of transcription by RNA polymerase II|metal ion binding|cardiac muscle tissue development|cardiac myofibril assembly|cardiac muscle contraction|muscle tissue development|protein kinase C signaling|regulation of protein localization to plasma membrane|negative regulation of actin filament severing|positive regulation of actin filament severing Disc1 26.533530229187946 12.171983861632452 36.10789447422493 2.9681730889777382 1.5695752251556911 0.0104512882583134 0.3847928744121958 Up 0.12190360139506022 0.12811802079358825 0.1798518140314797 0.02809172030956233 0.06835899273767497 307940 DISC1 scaffold protein GO:0000226,GO:0001764,GO:0001954,GO:0002052,GO:0005515,GO:0005634,GO:0005739,GO:0005783,GO:0005813,GO:0005829,GO:0005871,GO:0005874,GO:0007399,GO:0008021,GO:0008092,GO:0008104,GO:0010975,GO:0010976,GO:0014069,GO:0019894,GO:0021799,GO:0021846,GO:0021852,GO:0030177,GO:0030286,GO:0030424,GO:0031929,GO:0032091,GO:0034613,GO:0036064,GO:0044297,GO:0044877,GO:0045111,GO:0045773,GO:0048471,GO:0051560,GO:0051602,GO:0060070,GO:0060090,GO:0060271,GO:0060998,GO:0071539,GO:0090128,GO:0090263,GO:0090724,GO:0097546,GO:1905515,GO:2000060 microtubule cytoskeleton organization|neuron migration|positive regulation of cell-matrix adhesion|positive regulation of neuroblast proliferation|protein binding|nucleus|mitochondrion|endoplasmic reticulum|centrosome|cytosol|kinesin complex|microtubule|nervous system development|synaptic vesicle|cytoskeletal protein binding|protein localization|regulation of neuron projection development|positive regulation of neuron projection development|postsynaptic density|kinesin binding|cerebral cortex radially oriented cell migration|cell proliferation in forebrain|pyramidal neuron migration|positive regulation of Wnt signaling pathway|dynein complex|axon|TOR signaling|negative regulation of protein binding|cellular protein localization|ciliary basal body|cell body|protein-containing complex binding|intermediate filament cytoskeleton|positive regulation of axon extension|perinuclear region of cytoplasm|mitochondrial calcium ion homeostasis|response to electrical stimulus|canonical Wnt signaling pathway|molecular adaptor activity|cilium assembly|regulation of dendritic spine development|protein localization to centrosome|regulation of synapse maturation|positive regulation of canonical Wnt signaling pathway|central region of growth cone|ciliary base|non-motile cilium assembly|positive regulation of ubiquitin-dependent protein catabolic process Dnase2b 3.1461852135842974 0.0 5.243642022640494 28.134956292368628 4.8142918170590185 0.02607797730383414 0.5553053891064711 Up 0.02764893491691273 0.0028150350492132585 0.013452733314463424 0.0 0.0 59296 deoxyribonuclease 2 beta GO:0004520,GO:0004531,GO:0005576,GO:0005737,GO:0005764,GO:0006259,GO:0006309,GO:0090305 endodeoxyribonuclease activity|deoxyribonuclease II activity|extracellular region|cytoplasm|lysosome|DNA metabolic process|apoptotic DNA fragmentation|nucleic acid phosphodiester bond hydrolysis rno04142 Lysosome Dsc3 12.64754812360545 22.297043826689247 6.214550988216254 0.2792600383980137 -1.8403189535279736 0.02914412488325893 0.5748586180311852 Down 0.027890070520253416 0.04732643184717982 0.09951376672166004 0.2371886044205576 0.18062333207610806 307563 desmocollin 3 GO:0001701,GO:0005509,GO:0005576,GO:0005737,GO:0005886,GO:0005911,GO:0007156,GO:0016021,GO:0030054,GO:0030057,GO:0045295,GO:0050821,GO:0098609 in utero embryonic development|calcium ion binding|extracellular region|cytoplasm|plasma membrane|cell-cell junction|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane|cell junction|desmosome|gamma-catenin binding|protein stabilization|cell-cell adhesion Dusp27 62.94024831855256 35.9663250241097 80.92286384818112 2.248802842336086 1.1691571823018938 0.012209004560754444 0.4074887978723108 Up 0.7494828453291765 0.5942529219307957 0.28398673339111313 0.3316689278393244 0.14920996390849967 498267 dual specificity phosphatase 27, atypical GO:0006470,GO:0008138 protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity Efcab11 13.713038992856779 24.81405107248352 6.312364273105618 0.2537351518325459 -1.9786046942814188 0.04060058380488369 0.6380151107025377 Down 0.016137439275691463 0.2300213018077888 0.06281404115033175 0.6422804182719474 0.16501617348582293 500705 EF-hand calcium binding domain 11 GO:0005509 calcium ion binding Efnb3 7.8844342918168495 0.5076037320342007 12.802321331671946 25.262123801521405 4.6589040273272815 0.006982725872982771 0.32001728456090883 Up 0.07749710157594915 0.12821659095802934 0.1696797831363596 0.0 0.009905750023153307 360546 ephrin B3 GO:0005886,GO:0007411,GO:0007628,GO:0016198,GO:0031295,GO:0046875,GO:0048013,GO:0050771,GO:0098686,GO:0098978,GO:0099056,GO:0099061,GO:0099557 plasma membrane|axon guidance|adult walking behavior|axon choice point recognition|T cell costimulation|ephrin receptor binding|ephrin receptor signaling pathway|negative regulation of axonogenesis|hippocampal mossy fiber to CA3 synapse|glutamatergic synapse|integral component of presynaptic membrane|integral component of postsynaptic density membrane|trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission rno04360 Axon guidance Emid1 5.785156830139563 1.0122058334431543 8.967124161270501 8.841699058865386 3.1443236307326954 0.04667306677279988 0.6665523626758009 Up 0.1084990848300748 0.1657000861997366 0.021116317969839832 0.022145297762282714 0.0 685462 EMI domain containing 1 GO:0005783,GO:0005794,GO:0031012 endoplasmic reticulum|Golgi apparatus|extracellular matrix Fbp1 3.442537288151565 8.103649928795729 0.3351288610554544 0.04364438553765364 -4.51806011388005 0.01806344881685225 0.4798064527424439 Down 0.0 0.01712199507934425 0.0 0.2059470934574073 0.06878612586788042 24362 fructose-bisphosphatase 1 GO:0000122,GO:0005634,GO:0005737,GO:0005829,GO:0005975,GO:0005986,GO:0006000,GO:0006002,GO:0006094,GO:0006111,GO:0016208,GO:0016311,GO:0030308,GO:0030388,GO:0032869,GO:0035690,GO:0042132,GO:0042802,GO:0045820,GO:0046580,GO:0046872,GO:0048029,GO:0061629,GO:0071286 negative regulation of transcription by RNA polymerase II|nucleus|cytoplasm|cytosol|carbohydrate metabolic process|sucrose biosynthetic process|fructose metabolic process|fructose 6-phosphate metabolic process|gluconeogenesis|regulation of gluconeogenesis|AMP binding|dephosphorylation|negative regulation of cell growth|fructose 1,6-bisphosphate metabolic process|cellular response to insulin stimulus|cellular response to drug|fructose 1,6-bisphosphate 1-phosphatase activity|identical protein binding|negative regulation of glycolytic process|negative regulation of Ras protein signal transduction|metal ion binding|monosaccharide binding|RNA polymerase II-specific DNA-binding transcription factor binding|cellular response to magnesium ion rno00010,rno00030,rno00051,rno04152,rno04910,rno04922 Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|AMPK signaling pathway|Insulin signaling pathway|Glucagon signaling pathway Fbxl13 2.5707585084053166 0.0 4.284597514008861 22.97310132413323 4.521873725783655 0.039464390868751684 0.6328482126626939 Up 0.024501716409428977 0.03118257116670868 0.023842875509901558 0.0 0.0 100125363 F-box and leucine-rich repeat protein 13 GO:0019005,GO:0031146 SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Fbxo48 20.71934623913188 32.455121728623745 12.89549591280395 0.3968447166429886 -1.3333534964702844 0.048042259223445474 0.6768412026262685 Down 0.2370106977085315 0.536242011244817 0.25626397693713104 0.5643781446444747 1.157939278789199 364205 F-box protein 48 GO:0019005,GO:0031146 SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Fcgr2b 20.740685912485407 33.95091824909913 11.933864354742914 0.35076735556769234 -1.511413606375086 0.025914317946862987 0.5547295675482369 Down 0.07780132107908241 0.1584245081200157 0.045425565670507435 0.3096542406207877 0.22275983826420007 289211 Fc fragment of IgG receptor IIb GO:0001540,GO:0001811,GO:0002434,GO:0002638,GO:0002862,GO:0002865,GO:0002924,GO:0004888,GO:0005886,GO:0005887,GO:0006898,GO:0006911,GO:0006952,GO:0007166,GO:0009617,GO:0009897,GO:0009986,GO:0016021,GO:0016064,GO:0016358,GO:0019772,GO:0019864,GO:0019865,GO:0019886,GO:0021549,GO:0030889,GO:0032355,GO:0032456,GO:0032693,GO:0033030,GO:0038096,GO:0043197,GO:0044297,GO:0044877,GO:0045121,GO:0045576,GO:0046330,GO:0048169,GO:0050765,GO:0050766,GO:0050776,GO:0050777,GO:0050859,GO:0051091,GO:0055037,GO:0071219,GO:0071222,GO:1901216,GO:1902950,GO:1904646,GO:1905898 amyloid-beta binding|negative regulation of type I hypersensitivity|immune complex clearance|negative regulation of immunoglobulin production|negative regulation of inflammatory response to antigenic stimulus|negative regulation of acute inflammatory response to antigenic stimulus|negative regulation of humoral immune response mediated by circulating immunoglobulin|transmembrane signaling receptor activity|plasma membrane|integral component of plasma membrane|receptor-mediated endocytosis|phagocytosis, engulfment|defense response|cell surface receptor signaling pathway|response to bacterium|external side of plasma membrane|cell surface|integral component of membrane|immunoglobulin mediated immune response|dendrite development|low-affinity IgG receptor activity|IgG binding|immunoglobulin binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|cerebellum development|negative regulation of B cell proliferation|response to estradiol|endocytic recycling|negative regulation of interleukin-10 production|negative regulation of neutrophil apoptotic process|Fc-gamma receptor signaling pathway involved in phagocytosis|dendritic spine|cell body|protein-containing complex binding|membrane raft|mast cell activation|positive regulation of JNK cascade|regulation of long-term neuronal synaptic plasticity|negative regulation of phagocytosis|positive regulation of phagocytosis|regulation of immune response|negative regulation of immune response|negative regulation of B cell receptor signaling pathway|positive regulation of DNA-binding transcription factor activity|recycling endosome|cellular response to molecule of bacterial origin|cellular response to lipopolysaccharide|positive regulation of neuron death|regulation of dendritic spine maintenance|cellular response to amyloid-beta|positive regulation of response to endoplasmic reticulum stress rno04145,rno04380,rno04662,rno04666,rno05150,rno05152,rno05162 Phagosome|Osteoclast differentiation|B cell receptor signaling pathway|Fc gamma R-mediated phagocytosis|Staphylococcus aureus infection|Tuberculosis|Measles Fcrl2 15.130726862645984 29.39148955266707 5.62355173596526 0.1910253245320524 -2.388164183563993 0.009495392027649336 0.3755715991570837 Down 0.14707245925930393 0.04607373221350816 0.0 0.3810021228962035 0.2892143928535881 310694 Fc receptor-like 2 GO:0004888,GO:0005044,GO:0005887,GO:0006897,GO:0007166,GO:0009986,GO:0019903,GO:0035591 transmembrane signaling receptor activity|scavenger receptor activity|integral component of plasma membrane|endocytosis|cell surface receptor signaling pathway|cell surface|protein phosphatase binding|signaling adaptor activity Fermt3 27.933312555433226 43.08478379508949 17.832331728995708 0.41346703631066856 -1.274155779872438 0.02071626331543542 0.5056546751699205 Down 0.13430700626294378 0.2441833468199776 0.14003094329587226 0.4014023799844668 0.43163355640508255 309186 fermitin family member 3 GO:0002102,GO:0005178,GO:0007159,GO:0007160,GO:0007229,GO:0030055,GO:0030335,GO:0033622,GO:0033632,GO:0034446,GO:0070527 podosome|integrin binding|leukocyte cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|cell-substrate junction|positive regulation of cell migration|integrin activation|regulation of cell-cell adhesion mediated by integrin|substrate adhesion-dependent cell spreading|platelet aggregation rno04611 Platelet activation Fetub 4.587510065769647 0.5076037320342007 7.307447621593276 14.3954777793414 3.847543766973687 0.046367868396828216 0.6650108061045528 Up 0.08366439749561114 0.2385086418995083 0.04884881811784711 0.0 0.01711049503686644 83928 fetuin B GO:0004857,GO:0004866,GO:0004869,GO:0005576,GO:0005615,GO:0007338,GO:0007339,GO:0008191,GO:0010951 enzyme inhibitor activity|endopeptidase inhibitor activity|cysteine-type endopeptidase inhibitor activity|extracellular region|extracellular space|single fertilization|binding of sperm to zona pellucida|metalloendopeptidase inhibitor activity|negative regulation of endopeptidase activity Fgf11 31.486570975474052 17.73311268431931 40.655543169577186 2.2936613962726082 1.1976524279821956 0.0291573128933996 0.5748586180311852 Up 0.3692424269089743 0.2891835899282028 0.5067243818558698 0.21256664794751626 0.12585840776056004 170632 fibroblast growth factor 11 GO:0005576,GO:0005634,GO:0005737,GO:0007165,GO:0008083,GO:0017080,GO:1905150 extracellular region|nucleus|cytoplasm|signal transduction|growth factor activity|sodium channel regulator activity|regulation of voltage-gated sodium channel activity Fgf13 16.657032190994776 5.576136975813091 24.04429566778256 4.3115607132507465 2.108210195460784 0.005699726228300461 0.291360688015304 Up 0.17709348694382646 0.19533051529292725 0.16515103731568884 0.037651892086175656 0.04527250120896212 84488 fibroblast growth factor 13 GO:0000165,GO:0001764,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005874,GO:0005886,GO:0006814,GO:0006915,GO:0007026,GO:0007165,GO:0007399,GO:0007612,GO:0007613,GO:0008017,GO:0008083,GO:0014704,GO:0016328,GO:0017080,GO:0021766,GO:0021795,GO:0030175,GO:0030295,GO:0030424,GO:0030425,GO:0030426,GO:0032147,GO:0043005,GO:0044325,GO:0045200,GO:0046785,GO:0048487,GO:0048671,GO:0072659,GO:0098909,GO:1904862,GO:1905150,GO:1990834 MAPK cascade|neuron migration|extracellular region|nucleus|cytoplasm|cytosol|microtubule|plasma membrane|sodium ion transport|apoptotic process|negative regulation of microtubule depolymerization|signal transduction|nervous system development|learning|memory|microtubule binding|growth factor activity|intercalated disc|lateral plasma membrane|sodium channel regulator activity|hippocampus development|cerebral cortex cell migration|filopodium|protein kinase activator activity|axon|dendrite|growth cone|activation of protein kinase activity|neuron projection|ion channel binding|establishment of neuroblast polarity|microtubule polymerization|beta-tubulin binding|negative regulation of collateral sprouting|protein localization to plasma membrane|regulation of cardiac muscle cell action potential involved in regulation of contraction|inhibitory synapse assembly|regulation of voltage-gated sodium channel activity|response to odorant Fgf22 9.686590993651564 2.533516214233133 14.455307513263842 5.7061314724296555 2.5125129877954047 0.01639084723690985 0.4611232049201806 Up 0.25083632174152914 0.2979494674979014 0.3661371570489259 0.06399645033022168 0.04274950244367099 170579 fibroblast growth factor 22 GO:0001934,GO:0005104,GO:0005576,GO:0005730,GO:0005737,GO:0005794,GO:0008083,GO:0008284,GO:0008543,GO:0009887,GO:0009986,GO:0010628,GO:0030154,GO:0030334 positive regulation of protein phosphorylation|fibroblast growth factor receptor binding|extracellular region|nucleolus|cytoplasm|Golgi apparatus|growth factor activity|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|animal organ morphogenesis|cell surface|positive regulation of gene expression|cell differentiation|regulation of cell migration rno04010,rno04014,rno04015,rno04020,rno04151,rno04810,rno05200,rno05218,rno05224,rno05226 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer Fgfr4 21.930041130516386 9.124860654114624 30.466828114784214 3.336153497971201 1.7381856693782705 0.013425456661142374 0.4321195725755113 Up 0.1975554123079352 0.437256728270252 0.15880962474460278 0.07012559137308401 0.08783204354397894 25114 fibroblast growth factor receptor 4 GO:0001759,GO:0004714,GO:0005007,GO:0005524,GO:0005768,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0005911,GO:0007169,GO:0007275,GO:0008201,GO:0008284,GO:0008543,GO:0010628,GO:0010629,GO:0010715,GO:0010966,GO:0016477,GO:0017134,GO:0018108,GO:0019216,GO:0030133,GO:0030324,GO:0033674,GO:0042593,GO:0042632,GO:0043085,GO:0043235,GO:0045862,GO:0046777,GO:0051174,GO:0055062,GO:0061144,GO:0070374,GO:0070640,GO:0070857,GO:0090272,GO:1903412,GO:2000573,GO:2000830 organ induction|transmembrane receptor protein tyrosine kinase activity|fibroblast growth factor-activated receptor activity|ATP binding|endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|cell-cell junction|transmembrane receptor protein tyrosine kinase signaling pathway|multicellular organism development|heparin binding|positive regulation of cell population proliferation|fibroblast growth factor receptor signaling pathway|positive regulation of gene expression|negative regulation of gene expression|regulation of extracellular matrix disassembly|regulation of phosphate transport|cell migration|fibroblast growth factor binding|peptidyl-tyrosine phosphorylation|regulation of lipid metabolic process|transport vesicle|lung development|positive regulation of kinase activity|glucose homeostasis|cholesterol homeostasis|positive regulation of catalytic activity|receptor complex|positive regulation of proteolysis|protein autophosphorylation|regulation of phosphorus metabolic process|phosphate ion homeostasis|alveolar secondary septum development|positive regulation of ERK1 and ERK2 cascade|vitamin D3 metabolic process|regulation of bile acid biosynthetic process|negative regulation of fibroblast growth factor production|response to bile acid|positive regulation of DNA biosynthetic process|positive regulation of parathyroid hormone secretion rno04010,rno04014,rno04015,rno04020,rno04144,rno04151,rno04550,rno04810,rno05200 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Endocytosis|PI3K-Akt signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Pathways in cancer Folr1 11.695039879220841 4.562430327057312 16.45011291399652 3.6058918926133545 1.8503561443219565 0.036530193731771625 0.6160797505274177 Up 0.2904532972060278 0.2783253555171055 0.28264312960779864 0.06974496076856855 0.08735530512116679 171049 folate receptor alpha GO:0001947,GO:0003147,GO:0003253,GO:0005542,GO:0005634,GO:0005903,GO:0007155,GO:0007342,GO:0015884,GO:0016323,GO:0016324,GO:0017015,GO:0031103,GO:0031362,GO:0031526,GO:0035036,GO:0038023,GO:0046655,GO:0046658,GO:0048678,GO:0051870,GO:0060828,GO:0061626,GO:0061713,GO:0061714,GO:0071231,GO:1904447 heart looping|neural crest cell migration involved in heart formation|cardiac neural crest cell migration involved in outflow tract morphogenesis|folic acid binding|nucleus|brush border|cell adhesion|fusion of sperm to egg plasma membrane involved in single fertilization|folic acid transport|basolateral plasma membrane|apical plasma membrane|regulation of transforming growth factor beta receptor signaling pathway|axon regeneration|anchored component of external side of plasma membrane|brush border membrane|sperm-egg recognition|signaling receptor activity|folic acid metabolic process|anchored component of plasma membrane|response to axon injury|methotrexate binding|regulation of canonical Wnt signaling pathway|pharyngeal arch artery morphogenesis|anterior neural tube closure|folic acid receptor activity|cellular response to folic acid|folate import across plasma membrane rno01523,rno04144 Antifolate resistance|Endocytosis Gabrb3 5.230764504567165 11.140267429125194 1.2910958881951442 0.11684105780828427 -3.0973807702599974 0.04530936868478597 0.6607095246183405 Down 0.0 0.0 0.018264763280822525 0.08619655183025299 0.019193042135355626 24922 gamma-aminobutyric acid type A receptor subunit beta 3 GO:0004890,GO:0005216,GO:0005230,GO:0005254,GO:0005515,GO:0005886,GO:0005887,GO:0006821,GO:0007165,GO:0007214,GO:0007268,GO:0007399,GO:0007420,GO:0007605,GO:0007612,GO:0007613,GO:0009986,GO:0019098,GO:0021549,GO:0022851,GO:0030594,GO:0030659,GO:0034220,GO:0034707,GO:0035176,GO:0035612,GO:0035640,GO:0042391,GO:0042493,GO:0042747,GO:0042802,GO:0043005,GO:0043195,GO:0043523,GO:0043524,GO:0045202,GO:0045211,GO:0048666,GO:0050877,GO:0051932,GO:0060021,GO:0060022,GO:0060080,GO:0060119,GO:0060384,GO:0061744,GO:0071294,GO:0071420,GO:0072347,GO:0090102,GO:0098982,GO:0099055,GO:0099060,GO:1901215,GO:1902476,GO:1902711,GO:1904315,GO:1904862 GABA-A receptor activity|ion channel activity|extracellular ligand-gated ion channel activity|chloride channel activity|protein binding|plasma membrane|integral component of plasma membrane|chloride transport|signal transduction|gamma-aminobutyric acid signaling pathway|chemical synaptic transmission|nervous system development|brain development|sensory perception of sound|learning|memory|cell surface|reproductive behavior|cerebellum development|GABA-gated chloride ion channel activity|neurotransmitter receptor activity|cytoplasmic vesicle membrane|ion transmembrane transport|chloride channel complex|social behavior|AP-2 adaptor complex binding|exploration behavior|regulation of membrane potential|response to drug|circadian sleep/wake cycle, REM sleep|identical protein binding|neuron projection|terminal bouton|regulation of neuron apoptotic process|negative regulation of neuron apoptotic process|synapse|postsynaptic membrane|neuron development|nervous system process|synaptic transmission, GABAergic|roof of mouth development|hard palate development|inhibitory postsynaptic potential|inner ear receptor cell development|innervation|motor behavior|cellular response to zinc ion|cellular response to histamine|response to anesthetic|cochlea development|GABA-ergic synapse|integral component of postsynaptic membrane|integral component of postsynaptic specialization membrane|negative regulation of neuron death|chloride transmembrane transport|GABA-A receptor complex|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential|inhibitory synapse assembly rno04080,rno04723,rno04726,rno04727,rno05032,rno05033 Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|Serotonergic synapse|GABAergic synapse|Morphine addiction|Nicotine addiction Gata3 18.867970320144245 29.8945908387634 11.516889974398145 0.3852255579912479 -1.3762246721731697 0.04133020946401128 0.6423022553285559 Down 0.07993645763281054 0.16277222296086805 0.1555739994858622 0.4195413901289821 0.2685756192790598 85471 GATA binding protein 3 GO:0000122,GO:0000785,GO:0000902,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0000987,GO:0001227,GO:0001228,GO:0001701,GO:0001709,GO:0001764,GO:0001775,GO:0001806,GO:0001817,GO:0001819,GO:0001822,GO:0001823,GO:0002088,GO:0002520,GO:0002572,GO:0003180,GO:0003215,GO:0003281,GO:0003700,GO:0005134,GO:0005634,GO:0005654,GO:0006338,GO:0006357,GO:0006959,GO:0007165,GO:0007399,GO:0007411,GO:0008270,GO:0008285,GO:0008584,GO:0009615,GO:0009791,GO:0009967,GO:0010332,GO:0010595,GO:0010628,GO:0010629,GO:0010719,GO:0010975,GO:0014065,GO:0030182,GO:0030217,GO:0030218,GO:0030856,GO:0031929,GO:0032689,GO:0032703,GO:0032736,GO:0032753,GO:0032754,GO:0033077,GO:0033600,GO:0035162,GO:0035457,GO:0035799,GO:0035898,GO:0042421,GO:0042472,GO:0042493,GO:0042802,GO:0043370,GO:0043523,GO:0043565,GO:0043583,GO:0043627,GO:0045061,GO:0045064,GO:0045165,GO:0045471,GO:0045582,GO:0045597,GO:0045599,GO:0045786,GO:0045892,GO:0045893,GO:0045944,GO:0048469,GO:0048485,GO:0048538,GO:0048568,GO:0048589,GO:0048646,GO:0048872,GO:0050728,GO:0050852,GO:0051569,GO:0051897,GO:0060017,GO:0060037,GO:0060065,GO:0060231,GO:0060374,GO:0060676,GO:0061085,GO:0061290,GO:0070888,GO:0071345,GO:0071353,GO:0071356,GO:0071442,GO:0071599,GO:0071773,GO:0071837,GO:0072107,GO:0072178,GO:0072179,GO:0072182,GO:0072197,GO:0072676,GO:0090102,GO:1901536,GO:1902895,GO:1990837,GO:2000114,GO:2000146,GO:2000352,GO:2000553,GO:2000607,GO:2000611,GO:2000617,GO:2000679,GO:2000683,GO:2000703,GO:2000734 negative regulation of transcription by RNA polymerase II|chromatin|cell morphogenesis|transcription cis-regulatory region binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|cis-regulatory region sequence-specific DNA binding|DNA-binding transcription repressor activity, RNA polymerase II-specific|DNA-binding transcription activator activity, RNA polymerase II-specific|in utero embryonic development|cell fate determination|neuron migration|cell activation|type IV hypersensitivity|regulation of cytokine production|positive regulation of cytokine production|kidney development|mesonephros development|lens development in camera-type eye|immune system development|pro-T cell differentiation|aortic valve morphogenesis|cardiac right ventricle morphogenesis|ventricular septum development|DNA-binding transcription factor activity|interleukin-2 receptor binding|nucleus|nucleoplasm|chromatin remodeling|regulation of transcription by RNA polymerase II|humoral immune response|signal transduction|nervous system development|axon guidance|zinc ion binding|negative regulation of cell population proliferation|male gonad development|response to virus|post-embryonic development|positive regulation of signal transduction|response to gamma radiation|positive regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of gene expression|negative regulation of epithelial to mesenchymal transition|regulation of neuron projection development|phosphatidylinositol 3-kinase signaling|neuron differentiation|T cell differentiation|erythrocyte differentiation|regulation of epithelial cell differentiation|TOR signaling|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|T cell differentiation in thymus|negative regulation of mammary gland epithelial cell proliferation|embryonic hemopoiesis|cellular response to interferon-alpha|ureter maturation|parathyroid hormone secretion|norepinephrine biosynthetic process|inner ear morphogenesis|response to drug|identical protein binding|regulation of CD4-positive, alpha-beta T cell differentiation|regulation of neuron apoptotic process|sequence-specific DNA binding|ear development|response to estrogen|thymic T cell selection|T-helper 2 cell differentiation|cell fate commitment|response to ethanol|positive regulation of T cell differentiation|positive regulation of cell differentiation|negative regulation of fat cell differentiation|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|cell maturation|sympathetic nervous system development|thymus development|embryonic organ development|developmental growth|anatomical structure formation involved in morphogenesis|homeostasis of number of cells|negative regulation of inflammatory response|T cell receptor signaling pathway|regulation of histone H3-K4 methylation|positive regulation of protein kinase B signaling|parathyroid gland development|pharyngeal system development|uterus development|mesenchymal to epithelial transition|mast cell differentiation|ureteric bud formation|regulation of histone H3-K27 methylation|canonical Wnt signaling pathway involved in metanephric kidney development|E-box binding|cellular response to cytokine stimulus|cellular response to interleukin-4|cellular response to tumor necrosis factor|positive regulation of histone H3-K14 acetylation|otic vesicle development|cellular response to BMP stimulus|HMG box domain binding|positive regulation of ureteric bud formation|nephric duct morphogenesis|nephric duct formation|regulation of nephron tubule epithelial cell differentiation|ureter morphogenesis|lymphocyte migration|cochlea development|negative regulation of DNA demethylation|positive regulation of pri-miRNA transcription by RNA polymerase II|sequence-specific double-stranded DNA binding|regulation of establishment of cell polarity|negative regulation of cell motility|negative regulation of endothelial cell apoptotic process|positive regulation of T-helper 2 cell cytokine production|negative regulation of cell proliferation involved in mesonephros development|positive regulation of thyroid hormone generation|positive regulation of histone H3-K9 acetylation|positive regulation of transcription regulatory region DNA binding|regulation of cellular response to X-ray|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation rno04658,rno04659,rno04928,rno05321 Th1 and Th2 cell differentiation|Th17 cell differentiation|Parathyroid hormone synthesis, secretion and action|Inflammatory bowel disease zf-GATA Gbp3 7.14413553898023 2.0259124821989323 10.556284243501093 5.206609281659861 2.3803441469698554 0.04853515886023842 0.6812657141287924 Up 0.05434871890939761 0.07193463827464495 0.04759857414408137 0.016639337075499444 0.005557522153960885 685116 GO:0003924,GO:0005525,GO:0005737,GO:0005829,GO:0031410,GO:0042802,GO:0042803,GO:0071346,GO:0071347,GO:0071356 GTPase activity|GTP binding|cytoplasm|cytosol|cytoplasmic vesicle|identical protein binding|protein homodimerization activity|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to tumor necrosis factor rno04621 NOD-like receptor signaling pathway Gdf5 8.334339029599466 2.533516214233133 12.201554239843686 4.813626140381176 2.267124096452428 0.03845962451866266 0.63063538773659 Up 0.11753778654555147 0.16318546827817512 0.1143772446585214 0.03271384042439447 0.02185278080187655 252835 GO:0005102,GO:0005125,GO:0005615,GO:0007178,GO:0008083,GO:0009612,GO:0010862,GO:0030326,GO:0030509,GO:0030513,GO:0032331,GO:0032332,GO:0035136,GO:0035137,GO:0036122,GO:0040014,GO:0042802,GO:0043524,GO:0043932,GO:0045666,GO:0050680,GO:0060390,GO:0060395,GO:0060591,GO:2001054 signaling receptor binding|cytokine activity|extracellular space|transmembrane receptor protein serine/threonine kinase signaling pathway|growth factor activity|response to mechanical stimulus|positive regulation of pathway-restricted SMAD protein phosphorylation|embryonic limb morphogenesis|BMP signaling pathway|positive regulation of BMP signaling pathway|negative regulation of chondrocyte differentiation|positive regulation of chondrocyte differentiation|forelimb morphogenesis|hindlimb morphogenesis|BMP binding|regulation of multicellular organism growth|identical protein binding|negative regulation of neuron apoptotic process|ossification involved in bone remodeling|positive regulation of neuron differentiation|negative regulation of epithelial cell proliferation|regulation of SMAD protein signal transduction|SMAD protein signal transduction|chondroblast differentiation|negative regulation of mesenchymal cell apoptotic process rno04060,rno04350,rno04390 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway Gpd1 86.97665453325844 51.69753827123204 110.49606537460932 2.1365030286986983 1.0952513621795654 0.000792577192221504 0.08817708429113587 Up 0.8200463012261379 1.0019014852614223 0.6746690067661085 0.3956165815900024 0.3811602335462446 60666 glycerol-3-phosphate dehydrogenase 1 GO:0004367,GO:0004368,GO:0005829,GO:0005975,GO:0006072,GO:0006094,GO:0006116,GO:0006127,GO:0006734,GO:0009331,GO:0042803,GO:0045821,GO:0046168,GO:0046486,GO:0051287,GO:0071320,GO:0071356 glycerol-3-phosphate dehydrogenase [NAD+] activity|glycerol-3-phosphate dehydrogenase (quinone) activity|cytosol|carbohydrate metabolic process|glycerol-3-phosphate metabolic process|gluconeogenesis|NADH oxidation|glycerophosphate shuttle|NADH metabolic process|glycerol-3-phosphate dehydrogenase complex|protein homodimerization activity|positive regulation of glycolytic process|glycerol-3-phosphate catabolic process|glycerolipid metabolic process|NAD binding|cellular response to cAMP|cellular response to tumor necrosis factor rno00564 Glycerophospholipid metabolism Grid2ip 2.801487558654593 0.0 4.669145931090989 25.007380895214443 4.644282062148358 0.049506332804316114 0.6853658499050183 Up 0.019377783320004668 0.0493230023017141 0.0 0.0 0.0 288484 Grid2 interacting protein GO:0043197,GO:0045202,GO:0060292 dendritic spine|synapse|long-term synaptic depression Henmt1 29.946619260568472 44.630107220881456 20.157627287026482 0.4512435858029845 -1.1480216699146868 0.0473788433075515 0.6718015940205365 Down 0.08648681090510164 0.10406530244668737 0.0497316280838323 0.10431001405572424 0.2492360060189341 100363095 HEN methyltransferase 1 GO:0001510,GO:0003723,GO:0005634,GO:0005737,GO:0008171,GO:0008173,GO:0030422,GO:0034587,GO:0043186,GO:0046872,GO:0090486 RNA methylation|RNA binding|nucleus|cytoplasm|O-methyltransferase activity|RNA methyltransferase activity|production of siRNA involved in RNA interference|piRNA metabolic process|P granule|metal ion binding|small RNA 2'-O-methyltransferase Hgfac 10.432533526311898 2.533516214233133 15.698545067697733 6.1997587197269715 2.632212070237129 0.021125758157475714 0.5077688107071519 Up 0.039308336413951685 0.2001059806897897 0.3825135169952866 0.04011530676918891 0.02679694570416204 58947 HGF activator GO:0004252,GO:0005615,GO:0005737,GO:0005791,GO:0006508,GO:0007596,GO:0031638 serine-type endopeptidase activity|extracellular space|cytoplasm|rough endoplasmic reticulum|proteolysis|blood coagulation|zymogen activation Hrc 50.519339552889605 28.90189560438435 64.93096885189307 2.246262813612601 1.1675267334881965 0.006638913555029178 0.3121053934597089 Up 0.7318581873284626 0.7889616976383922 0.5969734284948967 0.2306549456793187 0.3961981240153579 292905 histidine rich calcium binding protein GO:0002027,GO:0005509,GO:0008016,GO:0010460,GO:0010880,GO:0030018,GO:0033017,GO:0033135,GO:0044325,GO:0045823,GO:0051117,GO:0051480,GO:0051481,GO:0055074,GO:0060314,GO:1901844,GO:1901899,GO:1902081,GO:1903169 regulation of heart rate|calcium ion binding|regulation of heart contraction|positive regulation of heart rate|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|Z disc|sarcoplasmic reticulum membrane|regulation of peptidyl-serine phosphorylation|ion channel binding|positive regulation of heart contraction|ATPase binding|regulation of cytosolic calcium ion concentration|negative regulation of cytosolic calcium ion concentration|calcium ion homeostasis|regulation of ryanodine-sensitive calcium-release channel activity|regulation of cell communication by electrical coupling involved in cardiac conduction|positive regulation of relaxation of cardiac muscle|negative regulation of calcium ion import into sarcoplasmic reticulum|regulation of calcium ion transmembrane transport rno04020,rno04260 Calcium signaling pathway|Cardiac muscle contraction Il17rb 13.863973977363074 23.324257813258637 7.557118086766032 0.32417435793614263 -1.6251581161275874 0.034925136283345766 0.6100177671879495 Down 0.06051409377501619 0.06161152155045457 0.07571172229767774 0.14997983405337895 0.2563588902599463 306247 interleukin 17 receptor B GO:0005654,GO:0005737,GO:0005886,GO:0009986,GO:0016021,GO:0019221,GO:0030368,GO:0032736,GO:0032754,GO:0034451,GO:0050729,GO:0072686 nucleoplasm|cytoplasm|plasma membrane|cell surface|integral component of membrane|cytokine-mediated signaling pathway|interleukin-17 receptor activity|positive regulation of interleukin-13 production|positive regulation of interleukin-5 production|centriolar satellite|positive regulation of inflammatory response|mitotic spindle rno04060,rno04657 Cytokine-cytokine receptor interaction|IL-17 signaling pathway Itgal 6.876983981459197 14.687490292114106 1.6699797743559286 0.11291387329515006 -3.1467053394718936 0.015415819626518931 0.4560290534218596 Down 0.0065194625533860715 0.026550774046039668 0.0 0.14637264792877214 0.046666123525254885 308995 integrin subunit alpha L GO:0001772,GO:0002291,GO:0005911,GO:0007157,GO:0007159,GO:0007160,GO:0007166,GO:0007229,GO:0009897,GO:0009986,GO:0022407,GO:0022409,GO:0030369,GO:0034687,GO:0035683,GO:0042102,GO:0043113,GO:0044877,GO:0046872,GO:0050798,GO:0050839,GO:0050850,GO:0098609 immunological synapse|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|cell-cell junction|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|leukocyte cell-cell adhesion|cell-matrix adhesion|cell surface receptor signaling pathway|integrin-mediated signaling pathway|external side of plasma membrane|cell surface|regulation of cell-cell adhesion|positive regulation of cell-cell adhesion|ICAM-3 receptor activity|integrin alphaL-beta2 complex|memory T cell extravasation|positive regulation of T cell proliferation|receptor clustering|protein-containing complex binding|metal ion binding|activated T cell proliferation|cell adhesion molecule binding|positive regulation of calcium-mediated signaling|cell-cell adhesion rno04015,rno04514,rno04613,rno04650,rno04670,rno04810,rno05144,rno05150,rno05166,rno05169,rno05323,rno05416 Rap1 signaling pathway|Cell adhesion molecules|Neutrophil extracellular trap formation|Natural killer cell mediated cytotoxicity|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Malaria|Staphylococcus aureus infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Rheumatoid arthritis|Viral myocarditis Itgb1bp2 76.10422229580601 43.58938589649845 97.78077989534435 2.244196903434786 1.166199262019106 0.0010431730815295187 0.10677224213815134 Up 1.7698438265550176 1.7595414912160667 2.6340347139187754 0.9137132623023092 0.9155379822955844 317258 integrin subunit beta 1 binding protein 2 GO:0005178,GO:0005509,GO:0007229,GO:0008270,GO:0030018 integrin binding|calcium ion binding|integrin-mediated signaling pathway|zinc ion binding|Z disc Itgb6 31.412113541255714 18.25122212354187 40.18604115306493 2.2015993176691886 1.1385519280253638 0.030019772534628064 0.5835469947070129 Up 0.24201293353956585 0.22449946955190045 0.18840424563723626 0.08232709188209422 0.11548810308400767 311061 integrin subunit beta 6 GO:0000902,GO:0005178,GO:0005654,GO:0005813,GO:0005925,GO:0006954,GO:0006955,GO:0007160,GO:0007179,GO:0007229,GO:0008305,GO:0009611,GO:0009615,GO:0009897,GO:0009986,GO:0010467,GO:0016477,GO:0030054,GO:0033627,GO:0034685,GO:0038023,GO:0042060,GO:0043129,GO:0043235,GO:0043588,GO:0048286,GO:0055091,GO:0060022,GO:0060348,GO:0060395,GO:0060435,GO:0061520,GO:0070166,GO:0071479,GO:0071604,GO:1901388 cell morphogenesis|integrin binding|nucleoplasm|centrosome|focal adhesion|inflammatory response|immune response|cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|integrin complex|response to wounding|response to virus|external side of plasma membrane|cell surface|gene expression|cell migration|cell junction|cell adhesion mediated by integrin|integrin alphav-beta6 complex|signaling receptor activity|wound healing|surfactant homeostasis|receptor complex|skin development|lung alveolus development|phospholipid homeostasis|hard palate development|bone development|SMAD protein signal transduction|bronchiole development|Langerhans cell differentiation|enamel mineralization|cellular response to ionizing radiation|transforming growth factor beta production|regulation of transforming growth factor beta activation rno04151,rno04510,rno04512,rno04810,rno05165,rno05410,rno05412,rno05414 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy|Arrhythmogenic right ventricular cardiomyopathy|Dilated cardiomyopathy Jsrp1 19.850165117642657 9.633965201461448 26.66096506176345 2.767646822870728 1.4686598535954007 0.0291140339184168 0.5748586180311852 Up 0.4395506644896607 0.3609047982410797 0.3449446218443629 0.10129097243575096 0.17398843601875638 690423 junctional sarcoplasmic reticulum protein 1 GO:0003009,GO:0016529,GO:0060314,GO:0072657 skeletal muscle contraction|sarcoplasmic reticulum|regulation of ryanodine-sensitive calcium-release channel activity|protein localization to membrane Katnal2 4.974838832228191 0.5076037320342007 7.952995565690847 15.67192292356548 3.970110302272212 0.03497923437669991 0.6102683924834928 Up 0.06450307212896925 0.1838839529398813 0.06276861151594144 0.0 0.013191746173553249 307253 GO:0000922,GO:0005524,GO:0005634,GO:0005737,GO:0005819,GO:0005874,GO:0008017,GO:0008568,GO:0016853,GO:0016887,GO:0031122,GO:0051013 spindle pole|ATP binding|nucleus|cytoplasm|spindle|microtubule|microtubule binding|microtubule-severing ATPase activity|isomerase activity|ATPase|cytoplasmic microtubule organization|microtubule severing Khdrbs2 2.6305745550943334 6.082239892534669 0.32946433013411097 0.058153451771259225 -4.103991362556329 0.04491322092922679 0.6587877174454619 Down 0.011786728774932354 0.0 0.0 0.07217220830192403 0.07231633893554917 170843 KH RNA binding domain containing, signal transduction associated 2 GO:0000381,GO:0003729,GO:0005515,GO:0005634,GO:0006397,GO:0008143,GO:0008266,GO:0017124,GO:0042169,GO:0048024 regulation of alternative mRNA splicing, via spliceosome|mRNA binding|protein binding|nucleus|mRNA processing|poly(A) binding|poly(U) RNA binding|SH3 domain binding|SH2 domain binding|regulation of mRNA splicing, via spliceosome Kif14 8.508618527188194 1.5198095654773551 13.16782450166208 8.660919465926089 3.11452019337192 0.011640223870117958 0.4007003521926481 Up 0.02609238231174075 0.06451638352062189 0.058036043592783526 0.007608011184423122 0.0038116023354624468 360849 GO:0001558,GO:0003777,GO:0005524,GO:0005829,GO:0005871,GO:0005874,GO:0005886,GO:0007018,GO:0007019,GO:0007080,GO:0008017,GO:0008284,GO:0008574,GO:0010389,GO:0015631,GO:0016887,GO:0019901,GO:0021685,GO:0021693,GO:0021695,GO:0021766,GO:0021772,GO:0021846,GO:0021987,GO:0030155,GO:0030165,GO:0030334,GO:0030496,GO:0031146,GO:0031641,GO:0032147,GO:0032467,GO:0032487,GO:0033624,GO:0034446,GO:0043066,GO:0043161,GO:0043523,GO:0043524,GO:0045184,GO:0051233,GO:0051301,GO:0090543,GO:0140603,GO:1903429,GO:2000045 regulation of cell growth|microtubule motor activity|ATP binding|cytosol|kinesin complex|microtubule|plasma membrane|microtubule-based movement|microtubule depolymerization|mitotic metaphase plate congression|microtubule binding|positive regulation of cell population proliferation|ATP-dependent microtubule motor activity, plus-end-directed|regulation of G2/M transition of mitotic cell cycle|tubulin binding|ATPase|protein kinase binding|cerebellar granular layer structural organization|cerebellar Purkinje cell layer structural organization|cerebellar cortex development|hippocampus development|olfactory bulb development|cell proliferation in forebrain|cerebral cortex development|regulation of cell adhesion|PDZ domain binding|regulation of cell migration|midbody|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of myelination|activation of protein kinase activity|positive regulation of cytokinesis|regulation of Rap protein signal transduction|negative regulation of integrin activation|substrate adhesion-dependent cell spreading|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of neuron apoptotic process|negative regulation of neuron apoptotic process|establishment of protein localization|spindle midzone|cell division|Flemming body|ATP hydrolysis activity|regulation of cell maturation|regulation of G1/S transition of mitotic cell cycle LOC100362384 497.57963748298914 772.2853799287648 314.44247585247194 0.4070116498910569 -1.2968580055567354 3.200041121027789e-16 2.456511566556983e-12 Down 8.786776043546983 10.32687730461877 7.808176659065207 25.027320019320484 18.952429890127593 100362384 GO:0005737,GO:0006826,GO:0006880,GO:0008198,GO:0008199 cytoplasm|iron ion transport|intracellular sequestering of iron ion|ferrous iron binding|ferric iron binding LOC100363314 27.131458572058225 12.666080255853045 36.775044116195005 2.9006291980477594 1.5363658803931581 0.01953471349087955 0.4949116439364253 Up 0.7275560657810046 1.0185317331189794 0.2831969550707003 0.2969968961620077 0.16739438074476204 100363314 LOC100910669 15.275317643274189 25.84876913561602 8.226349981712959 0.3182418027067395 -1.6518047413157777 0.025128040408346708 0.5465781310711929 Down 0.11111243487996862 0.22625493497704904 0.21624933602003746 0.5896461425774578 0.5680997002481196 100910669 GO:0016021,GO:0042288 integral component of membrane|MHC class I protein binding rno05168 Herpes simplex virus 1 infection LOC102547688 2.7381698765713915 0.0 4.563616460952317 24.503085321397467 4.614891513406289 0.03648308653754604 0.6160797505274177 Up 0.15894578803423628 0.10788552147024437 0.4640154069530942 0.0 0.0 102547688 LOC108351377 2.7866616918465907 0.0 4.6444361530776535 24.882308630705772 4.637048442717352 0.033920921675123776 0.6062723055624859 Up 0.230654088957728 0.4696740374351155 0.11222594852074358 0.0 0.0 108351377 LOC120093683 2.7622551656785603 0.0 4.603758609464267 24.69200311822457 4.625971973551363 0.03577411152492098 0.6139104206657168 Up 0.031391326928935995 0.007102358016226489 0.010182409095351 0.0 0.0 120093683 LOC120094192 18.341473108274048 32.46862906643737 8.923369136165169 0.27451416404680656 -1.865047505318444 0.015566676693134104 0.4593424794929519 Down 0.13674211747408746 0.18562926181421946 0.08871011944399493 0.18606577268071267 0.807895196664038 120094192 LOC120097399 4.855900340808656 10.64016777365411 0.9997220522450198 0.09330524089901623 -3.4218980711128286 0.0212225294772092 0.5083143448729998 Down 0.0290824720859744 0.059219769937471085 0.0 0.3858336715561192 0.23791027446912555 120097399 LOC500028 2.0268129713865064 5.067032428466266 0.0 0.035838405570792084 -4.802349735590131 0.03898292691764496 0.6314338950023847 Down 0.0 0.0 0.0 0.2427124634746185 0.16213144630488555 500028 hypothetical protein LOC500028 LOC685849 3.3556121969808217 0.0 5.5926869949680365 29.99377777932131 4.9065913390095535 0.020929161399350155 0.5071509115867817 Up 0.00578380335475496 0.04710954461087194 0.045026234425961965 0.0 0.0 685849 LOC685894 4.329794816873544 0.0 7.216324694789232 38.71706252107585 5.274897593805718 0.006360528400279853 0.3073711729482629 Up 0.2032734991004478 0.12934992483968044 0.2225335047590813 0.0 0.0 685894 Lmod2 28.44409106683041 11.665880944910874 39.62956448144343 3.39621455042246 1.7639276017217052 0.004287327520535337 0.25244959529209354 Up 0.4590172569416094 0.6395200437491234 0.3526377434331265 0.07396429473831491 0.2099840120032237 296935 leiomodin 2 GO:0003779,GO:0003785,GO:0005523,GO:0005856,GO:0005865,GO:0005884,GO:0006936,GO:0007015,GO:0030016,GO:0030017,GO:0030041,GO:0030239,GO:0030838,GO:0031430,GO:0045010,GO:0045214,GO:0051694,GO:0097512 actin binding|actin monomer binding|tropomyosin binding|cytoskeleton|striated muscle thin filament|actin filament|muscle contraction|actin filament organization|myofibril|sarcomere|actin filament polymerization|myofibril assembly|positive regulation of actin filament polymerization|M band|actin nucleation|sarcomere organization|pointed-end actin filament capping|cardiac myofibril Lmod3 111.88294472959915 63.87252376348975 143.88989204033874 2.2520582551637225 1.1712441468447805 0.0004025623575002836 0.05469504313895447 Up 2.1747100613878647 1.8137174675185697 1.0581165090101063 0.6728896117730183 0.8161772710386992 500267 GO:0003785,GO:0005523,GO:0005737,GO:0005856,GO:0005865,GO:0006936,GO:0006941,GO:0007015,GO:0030016,GO:0030239,GO:0030240,GO:0031430,GO:0031672,GO:0045010,GO:0048741,GO:0048743,GO:0051694 actin monomer binding|tropomyosin binding|cytoplasm|cytoskeleton|striated muscle thin filament|muscle contraction|striated muscle contraction|actin filament organization|myofibril|myofibril assembly|skeletal muscle thin filament assembly|M band|A band|actin nucleation|skeletal muscle fiber development|positive regulation of skeletal muscle fiber development|pointed-end actin filament capping Lrat 24.03650982565465 46.68153356339498 8.939827333827761 0.19124307157757087 -2.3865206126075087 0.005081467194010807 0.2732302337029501 Down 0.08497101876044079 0.04580045722793392 0.004863893154644593 0.06121087720731086 0.4088874509837391 64047 lecithin retinol acyltransferase GO:0001972,GO:0005771,GO:0005783,GO:0005789,GO:0005791,GO:0006776,GO:0007601,GO:0008374,GO:0009617,GO:0016021,GO:0019841,GO:0032370,GO:0032526,GO:0033189,GO:0042572,GO:0043231,GO:0047173,GO:0048471,GO:0102279,GO:1990830 retinoic acid binding|multivesicular body|endoplasmic reticulum|endoplasmic reticulum membrane|rough endoplasmic reticulum|vitamin A metabolic process|visual perception|O-acyltransferase activity|response to bacterium|integral component of membrane|retinol binding|positive regulation of lipid transport|response to retinoic acid|response to vitamin A|retinol metabolic process|intracellular membrane-bounded organelle|phosphatidylcholine-retinol O-acyltransferase activity|perinuclear region of cytoplasm|lecithin:11-cis retinol acyltransferase activity|cellular response to leukemia inhibitory factor rno00830,rno04977 Retinol metabolism|Vitamin digestion and absorption Lrrc39 23.613449513253002 13.178186433825113 30.57029156620491 2.320182831734245 1.2142384950267309 0.042461436393785 0.6475669471998655 Up 0.2697915004359516 0.2746841901828457 0.3168549033339492 0.12342384486496162 0.12367032695804685 691307 leucine rich repeat containing 39 GO:0004722,GO:0005737,GO:0006470,GO:0007165,GO:0031430,GO:0043231 protein serine/threonine phosphatase activity|cytoplasm|protein dephosphorylation|signal transduction|M band|intracellular membrane-bounded organelle Lsmem1 39.67551207417264 18.243718046978763 53.96337475896856 2.9577283836194885 1.5644895718428584 0.0009676503637652374 0.101755726266354 Up 0.4123336795751164 0.4198113827759081 0.41610716985773416 0.15585132500510607 0.12493005280342208 680810 GO:0016021 integral component of membrane Ltb 2.754842232274559 0.0 4.591403720457596 24.6335294120634 4.622551442191988 0.03847458844346356 0.63063538773659 Up 0.2061668397875582 0.02332285459866156 0.0891658221123716 0.0 0.0 361795 lymphotoxin beta GO:0005125,GO:0005164,GO:0005615,GO:0006955,GO:0007165,GO:0010467,GO:0016021,GO:0032735,GO:0043120,GO:0043588,GO:0048535 cytokine activity|tumor necrosis factor receptor binding|extracellular space|immune response|signal transduction|gene expression|integral component of membrane|positive regulation of interleukin-12 production|tumor necrosis factor binding|skin development|lymph node development rno04060,rno04064,rno05323 Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Rheumatoid arthritis Mab21l3 26.14466306929305 41.064874574141065 16.197855399394367 0.3939747291807036 -1.343825001385719 0.024677518644803977 0.5428977043037786 Down 0.14993103286299586 0.13183412869421735 0.05305434550547633 0.2364684597020927 0.3275356682388241 295326 mab-21 like 3 Marchf1 2.0268129713865064 5.067032428466266 0.0 0.035838405570792084 -4.802349735590131 0.03898292691764496 0.6314338950023847 Down 0.0 0.0 0.0 0.026276008475600243 0.01755232177318328 361135 membrane associated ring-CH-type finger 1 GO:0000209,GO:0002495,GO:0004842,GO:0005737,GO:0005764,GO:0005765,GO:0005768,GO:0005789,GO:0005886,GO:0006955,GO:0008270,GO:0016021,GO:0031901,GO:0031902,GO:0032588,GO:0042287,GO:0061630 protein polyubiquitination|antigen processing and presentation of peptide antigen via MHC class II|ubiquitin-protein transferase activity|cytoplasm|lysosome|lysosomal membrane|endosome|endoplasmic reticulum membrane|plasma membrane|immune response|zinc ion binding|integral component of membrane|early endosome membrane|late endosome membrane|trans-Golgi network membrane|MHC protein binding|ubiquitin protein ligase activity Mmd2 8.294358282866462 2.027413297511556 12.472321606436395 6.154185728135314 2.6215679836481383 0.024182875417168258 0.5398119534014619 Up 0.2229656193258037 0.08828132370308191 0.15670067626785306 0.0252825482786061 0.02533303848513837 304301 monocyte to macrophage differentiation-associated 2 GO:0004672,GO:0006468,GO:0016021,GO:0019835,GO:0032880,GO:0045666,GO:0045860,GO:0046579,GO:0048471 protein kinase activity|protein phosphorylation|integral component of membrane|cytolysis|regulation of protein localization|positive regulation of neuron differentiation|positive regulation of protein kinase activity|positive regulation of Ras protein signal transduction|perinuclear region of cytoplasm Mrc1 40.257413469141625 59.2875812067431 27.570634977407302 0.4652725191988932 -1.103852116445306 0.030430724022948774 0.5869383240255435 Down 0.06646787046593804 0.15616908563674775 0.2039925897820204 0.35481565938865506 0.25618658448949405 291327 mannose receptor, C type 1 GO:0004888,GO:0005537,GO:0005886,GO:0006898,GO:0009986,GO:0010008,GO:0016021,GO:0038023,GO:0038024,GO:0071222,GO:0071346,GO:0071353 transmembrane signaling receptor activity|mannose binding|plasma membrane|receptor-mediated endocytosis|cell surface|endosome membrane|integral component of membrane|signaling receptor activity|cargo receptor activity|cellular response to lipopolysaccharide|cellular response to interferon-gamma|cellular response to interleukin-4 rno04145,rno05152 Phagosome|Tuberculosis Mybpc1 99.4259514722262 48.17432845324512 133.59370015154693 2.772719948501211 1.471301908006759 0.046758086015882085 0.6665523626758009 Up 0.7407868550467175 1.5427249404803065 0.4456271240531716 0.21992571570818686 0.4338434277696488 362867 myosin binding protein C1 GO:0003779,GO:0006936,GO:0007155,GO:0017022,GO:0032982 actin binding|muscle contraction|cell adhesion|myosin binding|myosin filament Mybph 212.03995657386798 113.05305478892751 278.03122443049494 2.459452696745217 1.2983373076217748 9.403587704804486e-08 6.277099218776664e-05 Up 4.972697343765988 3.2768068879185086 3.3872885153932635 1.339178860807943 1.8079706970498344 83708 myosin binding protein H GO:0007155,GO:0032982 cell adhesion|myosin filament Myh15 42.5364225772683 23.297243137631412 55.36254220369288 2.3754415367750896 1.2481957002690398 0.016939143906813458 0.4647211015890029 Up 0.2792322004602035 0.2092735166075584 0.16227946984243194 0.13852447092786066 0.04362320585642033 303965 GO:0002074,GO:0003774,GO:0005524,GO:0005829,GO:0016459,GO:0043231,GO:0051015 extraocular skeletal muscle development|motor activity|ATP binding|cytosol|myosin complex|intracellular membrane-bounded organelle|actin filament binding Myh3 2534.788074945988 1282.1569838668645 3369.875468998735 2.6282600037799804 1.3941080030611042 3.206458155682613e-06 0.001330506812545815 Up 17.0332430511999 16.66345901443294 11.099939119450802 4.690345753754716 6.641483100509608 24583 myosin heavy chain 3 GO:0000146,GO:0003009,GO:0005516,GO:0005524,GO:0016459,GO:0030016,GO:0032982,GO:0043292,GO:0046034,GO:0051015 microfilament motor activity|skeletal muscle contraction|calmodulin binding|ATP binding|myosin complex|myofibril|myosin filament|contractile fiber|ATP metabolic process|actin filament binding Myh4 19.27078159783134 7.092944910665199 27.38933938927543 3.8600061222093616 1.948603135699076 0.026671411282574404 0.5601726093315524 Up 0.2667141483877366 0.07241360803119908 0.030279936932661167 0.04082843815717748 0.02272776338590251 360543 myosin heavy chain 4 GO:0003725,GO:0003774,GO:0005516,GO:0005524,GO:0006936,GO:0009629,GO:0014823,GO:0014850,GO:0016459,GO:0030016,GO:0032982,GO:0035994,GO:0051015,GO:0061061 double-stranded RNA binding|motor activity|calmodulin binding|ATP binding|muscle contraction|response to gravity|response to activity|response to muscle activity|myosin complex|myofibril|myosin filament|response to muscle stretch|actin filament binding|muscle structure development Myh8 14.706354560144728 5.068533243778888 21.13156877105529 4.167691408329292 2.0592484589612225 0.032070920834614894 0.5959266279603633 Up 0.19980324333875527 0.0632883037499691 0.02160340197213119 0.022656116943988204 0.02270136206766465 252942 myosin heavy chain 8 GO:0000146,GO:0003009,GO:0003779,GO:0005524,GO:0005737,GO:0016459,GO:0030016,GO:0030049,GO:0032982,GO:0046034,GO:0051015 microfilament motor activity|skeletal muscle contraction|actin binding|ATP binding|cytoplasm|myosin complex|myofibril|muscle filament sliding|myosin filament|ATP metabolic process|actin filament binding Mymk 227.8347878618044 121.14920064116016 298.9585126755672 2.4669932992226533 1.3027537970359373 6.478957005355317e-08 4.5214284956009165e-05 Up 5.830138046074718 5.6668202072264 3.471522674241668 1.8877636048025883 2.1448639250750485 296601 myomaker, myoblast fusion factor GO:0005886,GO:0005887,GO:0007520,GO:0014905,GO:0030173,GO:0043403,GO:0045026,GO:1904206 plasma membrane|integral component of plasma membrane|myoblast fusion|myoblast fusion involved in skeletal muscle regeneration|integral component of Golgi membrane|skeletal muscle tissue regeneration|plasma membrane fusion|positive regulation of skeletal muscle hypertrophy Mymx 90.34701946753158 46.09288580447911 119.84977524289991 2.59953619392304 1.3782542423243611 0.00019715074682195985 0.03254683242965107 Up 2.8130682090433416 2.56260095365784 2.305200827164428 1.4246166334379784 0.5407051692480126 108352018 GO:0000139,GO:0005789,GO:0005886,GO:0005887,GO:0007520,GO:0014905,GO:0043403,GO:0045026,GO:0060538 Golgi membrane|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|myoblast fusion|myoblast fusion involved in skeletal muscle regeneration|skeletal muscle tissue regeneration|plasma membrane fusion|skeletal muscle organ development Myo18b 9.340325938890876 2.535017029545757 13.877198545120955 5.471534199397934 2.4519454164770256 0.022155782849774104 0.5193247848741707 Up 0.035209309428168536 0.06517787814627754 0.034262545833824334 0.006533114521089744 0.009819242097361923 304551 GO:0001570,GO:0001701,GO:0003774,GO:0003779,GO:0005524,GO:0016461,GO:0030018,GO:0031941,GO:0055013 vasculogenesis|in utero embryonic development|motor activity|actin binding|ATP binding|unconventional myosin complex|Z disc|filamentous actin|cardiac muscle cell development Myo1g 8.456524443584566 2.027413297511556 12.742598540966569 6.291487249624502 2.653401097236866 0.023792261397051824 0.5371450142020223 Up 0.09891265922031957 0.05035322397640795 0.16844264362078334 0.016823876858222172 0.016857474777541244 289785 myosin IG GO:0001891,GO:0002456,GO:0005516,GO:0005524,GO:0005546,GO:0005547,GO:0005654,GO:0005886,GO:0005902,GO:0006887,GO:0006909,GO:0016459,GO:0030027,GO:0030175,GO:0031256,GO:0031589,GO:0038096,GO:0043325,GO:0071976,GO:0120117 phagocytic cup|T cell mediated immunity|calmodulin binding|ATP binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleoplasm|plasma membrane|microvillus|exocytosis|phagocytosis|myosin complex|lamellipodium|filopodium|leading edge membrane|cell-substrate adhesion|Fc-gamma receptor signaling pathway involved in phagocytosis|phosphatidylinositol-3,4-bisphosphate binding|cell gliding|T cell meandering migration Myom2 151.51315469045315 90.74250362442469 192.02692206780543 2.115494543770555 1.0809949647368946 5.958748053794642e-05 0.012706202620820714 Up 1.0751499439361372 1.1676243961647572 0.7373498217390454 0.4127644506564623 0.5235300720235254 306616 myomesin 2 GO:0002074,GO:0006936,GO:0019900,GO:0031430,GO:0045214,GO:0051015 extraocular skeletal muscle development|muscle contraction|kinase binding|M band|sarcomere organization|actin filament binding Myoz2 19.523572876340328 7.600548642699399 27.472255698767626 3.611598611421956 1.8526375623954567 0.018346229368391826 0.4851613489473942 Up 0.8768911647345757 0.7185900141093614 0.18731237450944246 0.19643994345967328 0.1312214943115081 295426 myozenin 2 GO:0000122,GO:0003779,GO:0007519,GO:0015629,GO:0030018,GO:0031433,GO:0043503,GO:0045214,GO:0051373,GO:0070885 negative regulation of transcription by RNA polymerase II|actin binding|skeletal muscle tissue development|actin cytoskeleton|Z disc|telethonin binding|skeletal muscle fiber adaptation|sarcomere organization|FATZ binding|negative regulation of calcineurin-NFAT signaling cascade Mypn 57.066078795887634 34.96162326722966 71.80238248165958 2.0546474765471108 1.0388908866249202 0.014411901177860459 0.4443090738628346 Up 0.3925067137275762 0.2459229866878619 0.4554047517930343 0.2156886195067844 0.13893387290326026 309760 myopalladin GO:0005634,GO:0008092,GO:0017124,GO:0030018,GO:0031674,GO:0045214,GO:0051371 nucleus|cytoskeletal protein binding|SH3 domain binding|Z disc|I band|sarcomere organization|muscle alpha-actinin binding Nebl 11.827080194658633 2.535017029545757 18.02178897140054 7.114005555948338 2.8306621011267783 0.0068580595662726465 0.31714394132826484 Up 0.017767870243209857 0.046517379288707014 0.07410042706615838 0.005180751758067467 0.007786646873337285 307189 nebulette GO:0001725,GO:0005523,GO:0008092,GO:0030018,GO:0031005,GO:0046872,GO:0051015,GO:0055001,GO:0071691 stress fiber|tropomyosin binding|cytoskeletal protein binding|Z disc|filamin binding|metal ion binding|actin filament binding|muscle cell development|cardiac muscle thin filament assembly Nos1ap 10.855700814165196 4.056327410335735 15.388616416718161 3.7972373666336394 1.9249501851465565 0.04362536911845159 0.6515372491007658 Up 0.1474152855046636 0.08442487862986581 0.19724560649100387 0.02820780179844482 0.04710688974509202 192363 nitric oxide synthase 1 adaptor protein GO:0002020,GO:0003062,GO:0005515,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005901,GO:0007269,GO:0030018,GO:0030165,GO:0030315,GO:0031102,GO:0031965,GO:0033017,GO:0045428,GO:0050998,GO:0050999,GO:0060307,GO:0098793,GO:0098794,GO:0098901,GO:0098974,GO:0098978,GO:1901215,GO:1901841,GO:1902514,GO:2000170 protease binding|regulation of heart rate by chemical signal|protein binding|nucleus|cytoplasm|mitochondrion|cytosol|caveola|neurotransmitter secretion|Z disc|PDZ domain binding|T-tubule|neuron projection regeneration|nuclear membrane|sarcoplasmic reticulum membrane|regulation of nitric oxide biosynthetic process|nitric-oxide synthase binding|regulation of nitric-oxide synthase activity|regulation of ventricular cardiac muscle cell membrane repolarization|presynapse|postsynapse|regulation of cardiac muscle cell action potential|postsynaptic actin cytoskeleton organization|glutamatergic synapse|negative regulation of neuron death|regulation of high voltage-gated calcium channel activity|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|positive regulation of peptidyl-cysteine S-nitrosylation rno04713 Circadian entrainment Npb 31.512604797928148 49.695638834035094 19.390582107190184 0.3903378525819318 -1.3572047215691372 0.01296012345865238 0.424721228995759 Down 0.23034858685314816 0.12628321801235556 0.16380529174815814 0.298367556506464 0.5888673184293753 259222 neuropeptide B GO:0001664,GO:0005576,GO:0007186,GO:0007218,GO:0007631 G protein-coupled receptor binding|extracellular region|G protein-coupled receptor signaling pathway|neuropeptide signaling pathway|feeding behavior rno04080 Neuroactive ligand-receptor interaction Npy 2.436497913764163 6.091244784410407 0.0 0.029815853981121233 -5.067776530970563 0.039771889513967984 0.6340787328223785 Down 0.0 0.0 0.0 0.0 0.5790408796603056 24604 neuropeptide Y GO:0001664,GO:0001878,GO:0002865,GO:0005179,GO:0005184,GO:0005615,GO:0005737,GO:0005794,GO:0007218,GO:0007268,GO:0007568,GO:0007631,GO:0008217,GO:0008284,GO:0008343,GO:0010811,GO:0019731,GO:0019732,GO:0021954,GO:0021987,GO:0031175,GO:0031640,GO:0031841,GO:0032100,GO:0032903,GO:0042117,GO:0043005,GO:0043195,GO:0043204,GO:0045087,GO:0045776,GO:0045964,GO:0048471,GO:0048572,GO:0050829,GO:0050830,GO:0050909,GO:0061844,GO:0070374,GO:0090274,GO:0090275,GO:0098992,GO:1901215,GO:1904000,GO:1904407 G protein-coupled receptor binding|response to yeast|negative regulation of acute inflammatory response to antigenic stimulus|hormone activity|neuropeptide hormone activity|extracellular space|cytoplasm|Golgi apparatus|neuropeptide signaling pathway|chemical synaptic transmission|aging|feeding behavior|regulation of blood pressure|positive regulation of cell population proliferation|adult feeding behavior|positive regulation of cell-substrate adhesion|antibacterial humoral response|antifungal humoral response|central nervous system neuron development|cerebral cortex development|neuron projection development|killing of cells of other organism|neuropeptide Y receptor binding|positive regulation of appetite|regulation of nerve growth factor production|monocyte activation|neuron projection|terminal bouton|perikaryon|innate immune response|negative regulation of blood pressure|positive regulation of dopamine metabolic process|perinuclear region of cytoplasm|short-day photoperiodism|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|sensory perception of taste|antimicrobial humoral immune response mediated by antimicrobial peptide|positive regulation of ERK1 and ERK2 cascade|positive regulation of somatostatin secretion|negative regulation of somatostatin secretion|neuronal dense core vesicle|negative regulation of neuron death|positive regulation of eating behavior|positive regulation of nitric oxide metabolic process rno04024,rno04080,rno04920,rno04923,rno05034 cAMP signaling pathway|Neuroactive ligand-receptor interaction|Adipocytokine signaling pathway|Regulation of lipolysis in adipocytes|Alcoholism Nr5a2 6.061413509945754 12.684090039604525 1.6462958235065734 0.1297702382489641 -2.9459685440148142 0.025620894204147992 0.5518361331493951 Down 0.01601189366792127 0.0054340901997280465 0.005193780182886996 0.021787474279588742 0.114612669627556 60349 nuclear receptor subfamily 5, group A, member 2 GO:0000976,GO:0000978,GO:0001228,GO:0003677,GO:0003682,GO:0003690,GO:0003700,GO:0004879,GO:0005543,GO:0005634,GO:0005737,GO:0006355,GO:0006357,GO:0008206,GO:0008270,GO:0009755,GO:0009888,GO:0030522,GO:0030855,GO:0042127,GO:0042632,GO:0043565,GO:0045070,GO:0045893,GO:0045944,GO:0061113,GO:0090575,GO:0097720,GO:1990830,GO:1990837 transcription cis-regulatory region binding|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription activator activity, RNA polymerase II-specific|DNA binding|chromatin binding|double-stranded DNA binding|DNA-binding transcription factor activity|nuclear receptor activity|phospholipid binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription by RNA polymerase II|bile acid metabolic process|zinc ion binding|hormone-mediated signaling pathway|tissue development|intracellular receptor signaling pathway|epithelial cell differentiation|regulation of cell population proliferation|cholesterol homeostasis|sequence-specific DNA binding|positive regulation of viral genome replication|positive regulation of transcription, DNA-templated|positive regulation of transcription by RNA polymerase II|pancreas morphogenesis|RNA polymerase II transcription regulator complex|calcineurin-mediated signaling|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding rno04950 Maturity onset diabetes of the young SF-like Nrap 4.946915900222113 0.0 8.244859833703519 44.20606291895496 5.4661723455731845 0.004917959927936289 0.2687026290875653 Up 0.08276016437857342 0.024782654813716068 0.01421201968166622 0.0 0.0 307982 nebulin-related anchoring protein GO:0003779,GO:0005916,GO:0005927,GO:0017166,GO:0030016,GO:0030018,GO:0046872,GO:0051015,GO:0051371,GO:0055001,GO:0071691 actin binding|fascia adherens|muscle tendon junction|vinculin binding|myofibril|Z disc|metal ion binding|actin filament binding|muscle alpha-actinin binding|muscle cell development|cardiac muscle thin filament assembly Obscn 237.4318856189784 111.00913252297713 321.7137210163125 2.8982560026554283 1.5351850336282284 8.437205339813561e-12 1.0794701131846468e-08 Up 0.3657084329042328 0.24457665788581026 0.2634170471409507 0.09513352839708666 0.10540580837032447 338458 GO:0004672,GO:0005085,GO:0005515,GO:0005524,GO:0005546,GO:0005547,GO:0005615,GO:0005829,GO:0005886,GO:0006468,GO:0010314,GO:0014067,GO:0014704,GO:0016604,GO:0030017,GO:0030018,GO:0030506,GO:0031430,GO:0031432,GO:0032266,GO:0042383,GO:0043325,GO:0045296,GO:0046777,GO:0050790,GO:0070273,GO:0106310,GO:0106311,GO:1902936 protein kinase activity|guanyl-nucleotide exchange factor activity|protein binding|ATP binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|extracellular space|cytosol|plasma membrane|protein phosphorylation|phosphatidylinositol-5-phosphate binding|negative regulation of phosphatidylinositol 3-kinase signaling|intercalated disc|nuclear body|sarcomere|Z disc|ankyrin binding|M band|titin binding|phosphatidylinositol-3-phosphate binding|sarcolemma|phosphatidylinositol-3,4-bisphosphate binding|cadherin binding|protein autophosphorylation|regulation of catalytic activity|phosphatidylinositol-4-phosphate binding|protein serine kinase activity|protein threonine kinase activity|phosphatidylinositol bisphosphate binding Osm 11.612189283865176 3.0441215768925804 17.324234421846896 5.698615979485933 2.510611575069707 0.01382378422045625 0.4384368863716757 Up 0.1406089491243807 0.10225635950163926 0.2834294976154515 0.01024968173457004 0.05135075368609129 289747 oncostatin M GO:0005125,GO:0005147,GO:0005615,GO:0006955,GO:0007260,GO:0007422,GO:0008083,GO:0008284,GO:0009408,GO:0014068,GO:0032740,GO:0033138,GO:0038165,GO:0040008,GO:0042531,GO:0043410,GO:0045835,GO:0045944,GO:0046888,GO:0048266,GO:0050729,GO:0050731,GO:0051897,GO:2001235 cytokine activity|oncostatin-M receptor binding|extracellular space|immune response|tyrosine phosphorylation of STAT protein|peripheral nervous system development|growth factor activity|positive regulation of cell population proliferation|response to heat|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of interleukin-17 production|positive regulation of peptidyl-serine phosphorylation|oncostatin-M-mediated signaling pathway|regulation of growth|positive regulation of tyrosine phosphorylation of STAT protein|positive regulation of MAPK cascade|negative regulation of meiotic nuclear division|positive regulation of transcription by RNA polymerase II|negative regulation of hormone secretion|behavioral response to pain|positive regulation of inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling|positive regulation of apoptotic signaling pathway rno04060,rno04151,rno04630 Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|JAK-STAT signaling pathway Ovol1 4.453379271539362 10.12806159568204 0.6702577221109088 0.06546667569734183 -3.933095466946096 0.02206772060373196 0.5188448919281727 Down 0.0 0.01817890835584698 0.0 0.14577325133610722 0.03651609151010937 309164 ovo like transcriptional repressor 1 GO:0000122,GO:0000978,GO:0000981,GO:0001227,GO:0001822,GO:0005634,GO:0006357,GO:0007283,GO:0007498,GO:0008544,GO:0009913,GO:0043588,GO:0046872,GO:0051729,GO:1901994,GO:1990837,GO:2000647 negative regulation of transcription by RNA polymerase II|RNA polymerase II cis-regulatory region sequence-specific DNA binding|DNA-binding transcription factor activity, RNA polymerase II-specific|DNA-binding transcription repressor activity, RNA polymerase II-specific|kidney development|nucleus|regulation of transcription by RNA polymerase II|spermatogenesis|mesoderm development|epidermis development|epidermal cell differentiation|skin development|metal ion binding|germline cell cycle switching, mitotic to meiotic cell cycle|negative regulation of meiotic cell cycle phase transition|sequence-specific double-stranded DNA binding|negative regulation of stem cell proliferation zf-C2H2 Pah 7.574857144871607 1.5213103807899788 11.610554987592693 7.627810130968426 2.9312689329900183 0.04618349588198134 0.6650108061045528 Up 0.2267446976194614 0.1539044868431452 0.0 0.011019028305445756 0.022082067444672667 24616 phenylalanine hydroxylase GO:0004505,GO:0005506,GO:0006558,GO:0006559,GO:0006571,GO:0016597,GO:0018126,GO:0019293,GO:0042802 phenylalanine 4-monooxygenase activity|iron ion binding|L-phenylalanine metabolic process|L-phenylalanine catabolic process|tyrosine biosynthetic process|amino acid binding|protein hydroxylation|tyrosine biosynthetic process, by oxidation of phenylalanine|identical protein binding rno00360,rno00400,rno00790 Phenylalanine metabolism|Phenylalanine, tyrosine and tryptophan biosynthesis|Folate biosynthesis Pianp 11.868392252549178 21.277333916682966 5.59576447645998 0.26294303751154 -1.927177798793456 0.023305059170066048 0.5285119253146588 Down 0.03440321826481908 0.02501937377960755 0.023912950088916703 0.1404379610479516 0.07035921048774654 312711 PILR alpha associated neural protein GO:0016020,GO:0016021,GO:0016323,GO:0050776 membrane|integral component of membrane|basolateral plasma membrane|regulation of immune response Pimreg 10.70334920292942 3.5457220476762874 15.475100639764838 4.36271497344164 2.12522622209064 0.027007423934293128 0.5611115724720724 Up 0.25711350697029617 0.2617762803241965 0.23456234285416674 0.08199745387656032 0.032864482359098425 360559 PICALM interacting mitotic regulator GO:0005654,GO:0005730 nucleoplasm|nucleolus Pla2g2d 7.07220028276798 15.204098916024046 1.6509345272639355 0.10838992899051697 -3.205697379435556 0.008598533524008111 0.3546783173004685 Down 0.0 0.041399839166013225 0.0263793516279762 0.2213183557519318 0.19404029477978327 298579 phospholipase A2, group IID GO:0002361,GO:0002864,GO:0005509,GO:0005543,GO:0005576,GO:0006644,GO:0008201,GO:0016042,GO:0042130,GO:0043395,GO:0046337,GO:0046470,GO:0046471,GO:0047498,GO:0050482,GO:0050868,GO:0102567,GO:0102568 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|regulation of acute inflammatory response to antigenic stimulus|calcium ion binding|phospholipid binding|extracellular region|phospholipid metabolic process|heparin binding|lipid catabolic process|negative regulation of T cell proliferation|heparan sulfate proteoglycan binding|phosphatidylethanolamine metabolic process|phosphatidylcholine metabolic process|phosphatidylglycerol metabolic process|calcium-dependent phospholipase A2 activity|arachidonic acid secretion|negative regulation of T cell activation|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) rno00564,rno00565,rno00590,rno00591,rno00592,rno04014,rno04270,rno04972,rno04975 Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Ras signaling pathway|Vascular smooth muscle contraction|Pancreatic secretion|Fat digestion and absorption Plppr3 47.10250006446672 27.383586854219608 60.24844220463143 2.200299184801506 1.1376997069692931 0.01101465318555437 0.3941910730951428 Up 0.6869002930782524 0.6993572830710871 0.6360864527337218 0.2035166619197112 0.4078461848042153 314614 phospholipid phosphatase related 3 GO:0005887,GO:0006644,GO:0007165,GO:0008195,GO:0016021,GO:0016311,GO:0042577,GO:0046839 integral component of plasma membrane|phospholipid metabolic process|signal transduction|phosphatidate phosphatase activity|integral component of membrane|dephosphorylation|lipid phosphatase activity|phospholipid dephosphorylation Pnma1 3.9149820427550237 0.0 6.52497007125837 35.02920197767737 5.130486216456926 0.011224426639987078 0.395797792414792 Up 0.04494267802759761 0.06101028929728265 0.18951481564309214 0.0 0.0 170636 PNMA family member 1 GO:0002437,GO:0005654,GO:0005730,GO:0005737,GO:0005829 inflammatory response to antigenic stimulus|nucleoplasm|nucleolus|cytoplasm|cytosol Prkag3 16.459778913584106 5.07303568971676 24.050941062828993 4.741877415676346 2.2454583675686046 0.014574000344155803 0.4466160225226029 Up 0.4442690076705272 0.1200048201376066 0.09705205714162576 0.01850569443639077 0.0741706040364607 301518 protein kinase AMP-activated non-catalytic subunit gamma 3 GO:0004679,GO:0005634,GO:0005737,GO:0005978,GO:0006096,GO:0006468,GO:0014873,GO:0016208,GO:0019887,GO:0019901,GO:0031588,GO:0042149,GO:0050790,GO:0071900 AMP-activated protein kinase activity|nucleus|cytoplasm|glycogen biosynthetic process|glycolytic process|protein phosphorylation|response to muscle activity involved in regulation of muscle adaptation|AMP binding|protein kinase regulator activity|protein kinase binding|nucleotide-activated protein kinase complex|cellular response to glucose starvation|regulation of catalytic activity|regulation of protein serine/threonine kinase activity rno04068,rno04152,rno04211,rno04213,rno04371,rno04530,rno04710,rno04714,rno04910,rno04920,rno04921,rno04922,rno04931,rno04932,rno05410 FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease|Hypertrophic cardiomyopathy Prlr 4.078379196069903 0.0 6.7972986601165 36.50878650890106 5.190171811683019 0.016292274243341592 0.4611232049201806 Up 0.001272574283904706 0.0012956525170623875 0.023528750586417964 0.0 0.0 24684 prolactin receptor GO:0004896,GO:0004923,GO:0004924,GO:0004925,GO:0005127,GO:0005886,GO:0007171,GO:0007259,GO:0007595,GO:0008284,GO:0009617,GO:0009897,GO:0009986,GO:0016021,GO:0017046,GO:0019221,GO:0019901,GO:0019955,GO:0030155,GO:0030856,GO:0038161,GO:0038165,GO:0042976,GO:0043066,GO:0043235,GO:0046872,GO:0048861,GO:0060644,GO:0060736,GO:0060749,GO:0061180,GO:0120162 cytokine receptor activity|leukemia inhibitory factor receptor activity|oncostatin-M receptor activity|prolactin receptor activity|ciliary neurotrophic factor receptor binding|plasma membrane|activation of transmembrane receptor protein tyrosine kinase activity|receptor signaling pathway via JAK-STAT|lactation|positive regulation of cell population proliferation|response to bacterium|external side of plasma membrane|cell surface|integral component of membrane|peptide hormone binding|cytokine-mediated signaling pathway|protein kinase binding|cytokine binding|regulation of cell adhesion|regulation of epithelial cell differentiation|prolactin signaling pathway|oncostatin-M-mediated signaling pathway|activation of Janus kinase activity|negative regulation of apoptotic process|receptor complex|metal ion binding|leukemia inhibitory factor signaling pathway|mammary gland epithelial cell differentiation|prostate gland growth|mammary gland alveolus development|mammary gland epithelium development|positive regulation of cold-induced thermogenesis rno04060,rno04080,rno04151,rno04630,rno04917 Cytokine-cytokine receptor interaction|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|JAK-STAT signaling pathway|Prolactin signaling pathway Ptprn2 7.268178935137018 14.182888190705151 2.6583727647582616 0.18674566745570795 -2.4208533223556934 0.04279671774469625 0.6486352009049089 Down 0.03352866456027123 0.03413670948776529 0.0 0.1710849131634999 0.06857063048608883 29714 protein tyrosine phosphatase, receptor type N2 GO:0004725,GO:0005515,GO:0005737,GO:0005788,GO:0006629,GO:0007269,GO:0030141,GO:0030285,GO:0030667,GO:0030672,GO:0034260,GO:0035335,GO:0035773,GO:0043195,GO:0043235 protein tyrosine phosphatase activity|protein binding|cytoplasm|endoplasmic reticulum lumen|lipid metabolic process|neurotransmitter secretion|secretory granule|integral component of synaptic vesicle membrane|secretory granule membrane|synaptic vesicle membrane|negative regulation of GTPase activity|peptidyl-tyrosine dephosphorylation|insulin secretion involved in cellular response to glucose stimulus|terminal bouton|receptor complex rno04940 Type I diabetes mellitus RGD1563222 11.895840449734688 20.7907415990255 5.965906350207478 0.28631300627404904 -1.8043348860908976 0.043069464258195016 0.6486352009049089 Down 0.01291098969877583 0.04819881548714874 0.016751758119229538 0.061488198483597274 0.1188212002938129 362175 similar to RIKEN cDNA A930018P22 Rassf7 11.467718074699867 2.0289141128241788 17.76025404928366 8.758132169605696 3.13062322177 0.0029199250744769514 0.2028489125268988 Up 0.2269584060997813 0.21823685245571345 0.2331253445237689 0.012867649453767477 0.038680039911332856 293623 Ras association domain family member 7 GO:0007165,GO:0034451,GO:0070507 signal transduction|centriolar satellite|regulation of microtubule cytoskeleton organization Rbm46 11.283877226895529 20.28013623636605 5.286371220581844 0.2603192598283168 -1.9416460408061362 0.03124229930473355 0.5929085552850113 Down 0.0853608184586558 0.048282690838774726 0.018459000394762504 0.15486793132021034 0.2327658126674181 310548 RNA binding motif protein 46 GO:0001829,GO:0003723,GO:0003729,GO:0005634,GO:0048255 trophectodermal cell differentiation|RNA binding|mRNA binding|nucleus|mRNA stabilization Rbmxl1b 6.123112570107354 0.0 10.20518761684559 54.727251238881074 5.774187491655256 0.0014292854133496655 0.13203586105815246 Up 0.2413338032389937 0.13104555223685724 0.12525036708027665 0.0 0.0 680944 GO:0003723,GO:0005681,GO:0006397,GO:0008380,GO:0048026 RNA binding|spliceosomal complex|mRNA processing|RNA splicing|positive regulation of mRNA splicing, via spliceosome rno03040 Spliceosome Retn 13.059818922692644 5.0655316131536425 18.38934379571864 3.6304975857744783 1.86016729349176 0.035800677119553176 0.6139104206657168 Up 0.4444497395198745 0.9050197399081958 1.1244965473041948 0.3175017690801696 0.1363439280595487 246250 resistin GO:0005179,GO:0005576,GO:0005615,GO:0005634,GO:0007165,GO:0007568,GO:0009612,GO:0010714,GO:0014911,GO:0032868,GO:0045444,GO:0048661,GO:0050806,GO:2000252,GO:2000872 hormone activity|extracellular region|extracellular space|nucleus|signal transduction|aging|response to mechanical stimulus|positive regulation of collagen metabolic process|positive regulation of smooth muscle cell migration|response to insulin|fat cell differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of synaptic transmission|negative regulation of feeding behavior|positive regulation of progesterone secretion Rnase6 14.704176026413224 27.86717754125184 5.928841683187471 0.21265934769456055 -2.2333838231534617 0.0046126268315379035 0.2594053470498221 Down 0.05497782394334886 0.14926626943143398 0.12483215095732025 0.6358734060208328 0.3935296663307796 305842 ribonuclease A family member k6 GO:0003676,GO:0004540,GO:0005615,GO:0019731,GO:0031410,GO:0045087,GO:0050829,GO:0050830,GO:0051607,GO:0061844,GO:0090501,GO:0090502 nucleic acid binding|ribonuclease activity|extracellular space|antibacterial humoral response|cytoplasmic vesicle|innate immune response|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|defense response to virus|antimicrobial humoral immune response mediated by antimicrobial peptide|RNA phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, endonucleolytic Rragd 13.689023772910387 24.833561671547624 6.2593318404855625 0.25193348531537085 -1.9888852066864882 0.010107484725062548 0.3806690116633436 Down 0.11079036985133103 0.13159948874993574 0.10781126317520708 0.4899475194363418 0.4342806597452292 297960 Ras-related GTP binding D GO:0003924,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005813,GO:0009267,GO:0010506,GO:0019003,GO:0032008,GO:0043231,GO:0046982,GO:0051020,GO:0071230,GO:0071233,GO:0071986,GO:1904263,GO:1990131,GO:1990253 GTPase activity|GTP binding|nucleus|nucleoplasm|cytoplasm|lysosome|centrosome|cellular response to starvation|regulation of autophagy|GDP binding|positive regulation of TOR signaling|intracellular membrane-bounded organelle|protein heterodimerization activity|GTPase binding|cellular response to amino acid stimulus|cellular response to leucine|Ragulator complex|positive regulation of TORC1 signaling|Gtr1-Gtr2 GTPase complex|cellular response to leucine starvation rno04140,rno04150 Autophagy - animal|mTOR signaling pathway Ryr1 469.0251552119605 291.46842660056967 587.3963076195545 2.0153284165406884 1.0110149585085964 2.3831141477506193e-11 2.613425107886804e-08 Up 1.1828692480664702 0.964522309271096 0.9575209254070328 0.4789440483764113 0.5459091391867846 114207 GO:0001666,GO:0002020,GO:0003151,GO:0005219,GO:0005245,GO:0005262,GO:0005509,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0005790,GO:0005886,GO:0005938,GO:0006816,GO:0006936,GO:0007275,GO:0014802,GO:0014808,GO:0016020,GO:0016021,GO:0016529,GO:0019899,GO:0030018,GO:0030314,GO:0030315,GO:0030659,GO:0031000,GO:0031234,GO:0031301,GO:0031674,GO:0032355,GO:0032991,GO:0033017,GO:0034704,GO:0042383,GO:0043588,GO:0043931,GO:0048741,GO:0048763,GO:0051209,GO:0051289,GO:0051480,GO:0070296,GO:0071277,GO:0071313,GO:0071318,GO:1990425 response to hypoxia|protease binding|outflow tract morphogenesis|ryanodine-sensitive calcium-release channel activity|voltage-gated calcium channel activity|calcium channel activity|calcium ion binding|protein binding|calmodulin binding|ATP binding|cytoplasm|smooth endoplasmic reticulum|plasma membrane|cell cortex|calcium ion transport|muscle contraction|multicellular organism development|terminal cisterna|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|membrane|integral component of membrane|sarcoplasmic reticulum|enzyme binding|Z disc|junctional membrane complex|T-tubule|cytoplasmic vesicle membrane|response to caffeine|extrinsic component of cytoplasmic side of plasma membrane|integral component of organelle membrane|I band|response to estradiol|protein-containing complex|sarcoplasmic reticulum membrane|calcium channel complex|sarcolemma|skin development|ossification involved in bone maturation|skeletal muscle fiber development|calcium-induced calcium release activity|release of sequestered calcium ion into cytosol|protein homotetramerization|regulation of cytosolic calcium ion concentration|sarcoplasmic reticulum calcium ion transport|cellular response to calcium ion|cellular response to caffeine|cellular response to ATP|ryanodine receptor complex rno04020,rno04371,rno04713,rno04730,rno04921,rno05017,rno05020,rno05022 Calcium signaling pathway|Apelin signaling pathway|Circadian entrainment|Long-term depression|Oxytocin signaling pathway|Spinocerebellar ataxia|Prion disease|Pathways of neurodegeneration - multiple diseases Scn5a 59.91229091375992 30.420204354549078 79.5736819532338 2.6163630672134266 1.3875627544918263 0.00045195257282945286 0.0588036258529711 Up 0.2162280777720373 0.2584362412590973 0.2805517270118003 0.0767537656806594 0.11536056878685635 25665 sodium voltage-gated channel alpha subunit 5 GO:0001518,GO:0002027,GO:0003231,GO:0003360,GO:0005244,GO:0005248,GO:0005515,GO:0005516,GO:0005654,GO:0005730,GO:0005783,GO:0005886,GO:0005901,GO:0006814,GO:0009986,GO:0010460,GO:0010765,GO:0014070,GO:0014704,GO:0014894,GO:0016021,GO:0016328,GO:0017134,GO:0019228,GO:0019899,GO:0019901,GO:0019904,GO:0021537,GO:0021549,GO:0030018,GO:0030315,GO:0030506,GO:0031625,GO:0034706,GO:0034765,GO:0035725,GO:0042383,GO:0042475,GO:0044325,GO:0045760,GO:0048471,GO:0050679,GO:0050998,GO:0051899,GO:0055074,GO:0060048,GO:0060307,GO:0060371,GO:0060372,GO:0060373,GO:0071277,GO:0086002,GO:0086004,GO:0086005,GO:0086006,GO:0086010,GO:0086012,GO:0086014,GO:0086015,GO:0086016,GO:0086043,GO:0086045,GO:0086046,GO:0086047,GO:0086048,GO:0086060,GO:0086061,GO:0086062,GO:0086063,GO:0086065,GO:0086067,GO:0086091,GO:0097110,GO:0098719,GO:0098912,GO:1902305 voltage-gated sodium channel complex|regulation of heart rate|cardiac ventricle development|brainstem development|voltage-gated ion channel activity|voltage-gated sodium channel activity|protein binding|calmodulin binding|nucleoplasm|nucleolus|endoplasmic reticulum|plasma membrane|caveola|sodium ion transport|cell surface|positive regulation of heart rate|positive regulation of sodium ion transport|response to organic cyclic compound|intercalated disc|response to denervation involved in regulation of muscle adaptation|integral component of membrane|lateral plasma membrane|fibroblast growth factor binding|neuronal action potential|enzyme binding|protein kinase binding|protein domain specific binding|telencephalon development|cerebellum development|Z disc|T-tubule|ankyrin binding|ubiquitin protein ligase binding|sodium channel complex|regulation of ion transmembrane transport|sodium ion transmembrane transport|sarcolemma|odontogenesis of dentin-containing tooth|ion channel binding|positive regulation of action potential|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|nitric-oxide synthase binding|membrane depolarization|calcium ion homeostasis|cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of atrial cardiac muscle cell membrane depolarization|regulation of atrial cardiac muscle cell membrane repolarization|regulation of ventricular cardiac muscle cell membrane depolarization|cellular response to calcium ion|cardiac muscle cell action potential involved in contraction|regulation of cardiac muscle cell contraction|ventricular cardiac muscle cell action potential|voltage-gated sodium channel activity involved in cardiac muscle cell action potential|membrane depolarization during action potential|membrane depolarization during cardiac muscle cell action potential|atrial cardiac muscle cell action potential|SA node cell action potential|AV node cell action potential|bundle of His cell action potential|membrane depolarization during AV node cell action potential|membrane depolarization during SA node cell action potential|membrane depolarization during Purkinje myocyte cell action potential|membrane depolarization during bundle of His cell action potential|voltage-gated sodium channel activity involved in AV node cell action potential|voltage-gated sodium channel activity involved in bundle of His cell action potential|voltage-gated sodium channel activity involved in Purkinje myocyte action potential|voltage-gated sodium channel activity involved in SA node cell action potential|cell communication involved in cardiac conduction|AV node cell to bundle of His cell communication|regulation of heart rate by cardiac conduction|scaffold protein binding|sodium ion import across plasma membrane|membrane depolarization during atrial cardiac muscle cell action potential|regulation of sodium ion transmembrane transport rno04261 Adrenergic signaling in cardiomyocytes Sec14l4 4.1691808858130806 0.0 6.948634809688468 37.238658672873996 5.218729203207166 0.00780094972904441 0.34510588636335265 Up 0.06414079460057366 0.09329141839464623 0.035666328844948636 0.0 0.0 498399 SEC14-like lipid binding 4 Sh2d4a 28.35199433517126 15.211602992587164 37.11225523022731 2.440774230025258 1.2873388529696244 0.024717351352070687 0.5428977043037786 Up 0.2201817126145848 0.27828586554044304 0.3546390927148129 0.08523174618326912 0.14751247154229266 306376 SH2 domain containing 4A GO:0005737,GO:0005829,GO:0010923,GO:0019902 cytoplasm|cytosol|negative regulation of phosphatase activity|phosphatase binding Slamf9 2.2280534858250385 5.570133714562597 0.0 0.03259980115669297 -4.93899302504622 0.031085224126272907 0.5913896480925254 Down 0.0 0.0 0.0 0.2053018957961999 0.04571375365739255 289235 SLAM family member 9 GO:0002273,GO:0002410,GO:0009986,GO:0016021,GO:0042742 plasmacytoid dendritic cell differentiation|plasmacytoid dendritic cell chemotaxis|cell surface|integral component of membrane|defense response to bacterium Slc16a10 3.0348565623465458 7.092944910665199 0.32946433013411097 0.049864851430039714 -4.3258329380409775 0.02765281170568103 0.5668716912900467 Down 0.0036298839125079967 0.0 0.0 0.033339624103656394 0.018559002553214923 170566 solute carrier family 16 member 10 GO:0005887,GO:0006590,GO:0015173,GO:0015349,GO:0015801,GO:0016021,GO:0016323,GO:0030054,GO:0043231,GO:0055085,GO:0070327,GO:0070460 integral component of plasma membrane|thyroid hormone generation|aromatic amino acid transmembrane transporter activity|thyroid hormone transmembrane transporter activity|aromatic amino acid transport|integral component of membrane|basolateral plasma membrane|cell junction|intracellular membrane-bounded organelle|transmembrane transport|thyroid hormone transport|thyroid-stimulating hormone secretion rno04919,rno04974 Thyroid hormone signaling pathway|Protein digestion and absorption Slc17a9 19.865039922634143 33.97643210941373 10.457445131447745 0.3084176904025565 -1.6970425763138028 0.015945964991248198 0.4607793649426989 Down 0.06853451413702982 0.034888696428325684 0.11337580455066926 0.15387124669561494 0.31536518196150737 362287 solute carrier family 17 member 9 GO:0001409,GO:0005347,GO:0015217,GO:0015866,GO:0015867,GO:0016021,GO:0030141,GO:0042584,GO:1903790 guanine nucleotide transmembrane transporter activity|ATP transmembrane transporter activity|ADP transmembrane transporter activity|ADP transport|ATP transport|integral component of membrane|secretory granule|chromaffin granule membrane|guanine nucleotide transmembrane transport Slc22a20 52.32874079986432 75.52489737058701 36.86463641938253 0.4880718636430666 -1.034834509213177 0.00831666771956861 0.3507941423505186 Down 0.43177100671108265 0.5814080484230634 0.5421430516775119 1.0234101791485737 1.0966660491536215 293686 solute carrier family 22 member 20 GO:0016021,GO:0022857,GO:0055085 integral component of membrane|transmembrane transporter activity|transmembrane transport Slc51a 5.957049881823299 0.5076037320342007 9.590013981682695 18.90410927372321 4.240627968721564 0.02000094058319495 0.5001009382788348 Up 0.2336757582453837 0.1869320248806012 0.06496923283047414 0.0 0.017067798854615998 303879 solute carrier family 51 subunit alpha GO:0005215,GO:0005789,GO:0005886,GO:0006810,GO:0015125,GO:0015721,GO:0016021,GO:0016323,GO:0022857,GO:0032782,GO:0032991,GO:0042803,GO:0046982,GO:0055085,GO:0071702 transporter activity|endoplasmic reticulum membrane|plasma membrane|transport|bile acid transmembrane transporter activity|bile acid and bile salt transport|integral component of membrane|basolateral plasma membrane|transmembrane transporter activity|bile acid secretion|protein-containing complex|protein homodimerization activity|protein heterodimerization activity|transmembrane transport|organic substance transport rno04976 Bile secretion Slc51b 5.1119981406532125 0.5061029167215773 8.18259495660763 16.158183736142647 4.014193135667482 0.03190360526717504 0.5959266279603633 Up 0.14384878666180884 0.25630061720249586 0.4899326354776548 0.03670047330765401 0.0 300790 GO:0005215,GO:0005886,GO:0015125,GO:0015721,GO:0016021,GO:0016323,GO:0022857,GO:0031647,GO:0032782,GO:0032991,GO:0046982,GO:0055085,GO:0060050,GO:0070863,GO:0071702,GO:0090314 transporter activity|plasma membrane|bile acid transmembrane transporter activity|bile acid and bile salt transport|integral component of membrane|basolateral plasma membrane|transmembrane transporter activity|regulation of protein stability|bile acid secretion|protein-containing complex|protein heterodimerization activity|transmembrane transport|positive regulation of protein glycosylation|positive regulation of protein exit from endoplasmic reticulum|organic substance transport|positive regulation of protein targeting to membrane rno04976 Bile secretion Slc5a5 17.10941665051583 29.388487922041826 8.923369136165169 0.3031826457802198 -1.7217409190939188 0.015121902998217163 0.4516859469486928 Down 0.08461098695427548 0.11486055167070992 0.05489055528491745 0.3357977248528849 0.22110775684147474 114613 solute carrier family 5 member 5 GO:0005634,GO:0005886,GO:0006590,GO:0006814,GO:0008507,GO:0015111,GO:0015293,GO:0015705,GO:0016021,GO:0071320,GO:0071371,GO:1904200 nucleus|plasma membrane|thyroid hormone generation|sodium ion transport|sodium:iodide symporter activity|iodide transmembrane transporter activity|symporter activity|iodide transport|integral component of membrane|cellular response to cAMP|cellular response to gonadotropin stimulus|iodide transmembrane transport rno04918 Thyroid hormone synthesis Slc6a14 4.885883631380179 0.5076037320342007 7.804736897610828 15.415955551187794 3.9463524119181828 0.04173538618081365 0.6447770885662149 Up 0.058778282774816434 0.023937692593353863 0.19447238179517254 0.0 0.012020949720540177 298340 solute carrier family 6 member 14 GO:0005887,GO:0009636,GO:0015293,GO:0022858,GO:0031526,GO:0032328,GO:0035725,GO:0089718 integral component of plasma membrane|response to toxic substance|symporter activity|alanine transmembrane transporter activity|brush border membrane|alanine transport|sodium ion transmembrane transport|amino acid import across plasma membrane Smpx 15.234575964788988 4.056327410335735 22.686741667757826 5.594195638998901 2.4839307083150186 0.012496331669926544 0.41527311716100057 Up 1.3184054012308393 0.1579193864999229 0.30187153689057983 0.07914536852433213 0.13217237470506976 84416 small muscle protein, X-linked GO:0005634,GO:0005737,GO:0005927,GO:0031430,GO:0043034,GO:0043292 nucleus|cytoplasm|muscle tendon junction|M band|costamere|contractile fiber Sorcs1 37.09834601277995 53.232355989835646 26.342339361409486 0.4947834219536484 -1.015130932216437 0.043487205240475287 0.6507398265662935 Down 0.03819357772996257 0.08814210142958201 0.07681090804731518 0.11433447794055593 0.1588257114009246 309533 sortilin-related VPS10 domain containing receptor 1 GO:0005794,GO:0006892,GO:0016020,GO:0016021 Golgi apparatus|post-Golgi vesicle-mediated transport|membrane|integral component of membrane Spaar 22.80223513395274 11.662879314285627 30.228472347064127 2.5928762094299485 1.3745533298685402 0.029167906171190857 0.5748586180311852 Up 0.1169838352490163 0.11910534615781193 0.14636338570350568 0.03411012135027431 0.06408420103985657 120102861 GO:0031902,GO:0043416,GO:0071230,GO:1904262,GO:1905103 late endosome membrane|regulation of skeletal muscle tissue regeneration|cellular response to amino acid stimulus|negative regulation of TORC1 signaling|integral component of lysosomal membrane Spag17 8.934157090773141 2.535017029545757 13.200250464924725 5.2055316715998785 2.3800455219892527 0.02765497927286165 0.5668716912900467 Up 0.03386819534062841 0.06206831583319755 0.039548992491360783 0.0069126967445302745 0.010389752492639029 690746 GO:0003351,GO:0005576,GO:1904158,GO:1990716 epithelial cilium movement involved in extracellular fluid movement|extracellular region|axonemal central apparatus assembly|axonemal central apparatus Srl 365.0070353693843 196.7101175792501 477.20498056280695 2.425855125983371 1.2784933941244112 4.042818238514217e-11 4.137959227727252e-08 Up 2.0256257713601653 1.6427150928803698 1.4260896304982231 0.5752237449036384 0.8213307961264611 302948 sarcalumenin GO:0002115,GO:0005525,GO:0005737,GO:0005886,GO:0006897,GO:0014873,GO:0016020,GO:0016197,GO:0043231 store-operated calcium entry|GTP binding|cytoplasm|plasma membrane|endocytosis|response to muscle activity involved in regulation of muscle adaptation|membrane|endosomal transport|intracellular membrane-bounded organelle St8sia2 5.370196028389122 0.5076037320342007 8.61192422595907 16.971599850132158 4.085050663719652 0.02714009841937765 0.5612610958154545 Up 0.13124815713642266 0.2672567052538989 0.09122782080172567 0.0 0.019172867248738217 117523 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 GO:0000139,GO:0001574,GO:0003828,GO:0005769,GO:0005886,GO:0006486,GO:0006491,GO:0008373,GO:0009311,GO:0016021,GO:0030182,GO:0042220,GO:0048471,GO:0051965,GO:0055037,GO:0097503,GO:1901216,GO:1990138 Golgi membrane|ganglioside biosynthetic process|alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity|early endosome|plasma membrane|protein glycosylation|N-glycan processing|sialyltransferase activity|oligosaccharide metabolic process|integral component of membrane|neuron differentiation|response to cocaine|perinuclear region of cytoplasm|positive regulation of synapse assembly|recycling endosome|sialylation|positive regulation of neuron death|neuron projection extension Stab1 98.52389252057013 146.47235626099047 66.55825002695654 0.4547896450735673 -1.1367286884388244 0.0003190005070366337 0.046643950328889884 Down 0.17891466110034096 0.17884730519717712 0.29755908636357153 0.4979663004418465 0.4623703024181121 100363145 GO:0005041,GO:0005044,GO:0005509,GO:0005540,GO:0005887,GO:0006897,GO:0007155,GO:0007267,GO:0016525,GO:0030169,GO:0042742 low-density lipoprotein particle receptor activity|scavenger receptor activity|calcium ion binding|hyaluronic acid binding|integral component of plasma membrane|endocytosis|cell adhesion|cell-cell signaling|negative regulation of angiogenesis|low-density lipoprotein particle binding|defense response to bacterium Susd5 5.866671631879412 13.678286089296195 0.6589286602682219 0.04813322653887951 -4.37682305432526 0.004895730923533814 0.26848611660855715 Down 0.010773454527520213 0.0 0.0 0.09895162845502366 0.04957461930250553 301039 GO:0005540,GO:0007155,GO:0007219,GO:0016021 hyaluronic acid binding|cell adhesion|Notch signaling pathway|integral component of membrane Syce1 5.248194914072854 11.155275582251427 1.3101411352871375 0.1177323629656362 -3.086417143480864 0.022121103432352258 0.5193047415854806 Down 0.018490583496265683 0.018825911659458672 0.03598675888985834 0.15096144929312832 0.2647101187942585 502372 synaptonemal complex central element protein 1 GO:0000795,GO:0000801,GO:0005654,GO:0005694,GO:0005829,GO:0007130,GO:0043231,GO:0051301 synaptonemal complex|central element|nucleoplasm|chromosome|cytosol|synaptonemal complex assembly|intracellular membrane-bounded organelle|cell division Synpr 22.490712720242023 35.997842145674795 13.485959769953508 0.3746876948273905 -1.4162394961982003 0.020473113389898046 0.5029113463000882 Down 0.09789928400693904 0.14951204265223214 0.15242690117416766 0.2797454299103726 0.4304669986278177 66030 synaptoporin GO:0008021,GO:0016021,GO:0017075,GO:0030285,GO:0030672,GO:0043005 synaptic vesicle|integral component of membrane|syntaxin-1 binding|integral component of synaptic vesicle membrane|synaptic vesicle membrane|neuron projection Syt4 3.122715420775518 0.0 5.204525701292528 27.94333964212851 4.8044325493215485 0.0356799847623848 0.6139104206657168 Up 0.04140707916290396 0.0 0.06715610022391671 0.0 0.0 64440 synaptotagmin 4 GO:0000149,GO:0001786,GO:0005509,GO:0005515,GO:0005543,GO:0005544,GO:0005794,GO:0005886,GO:0006906,GO:0007269,GO:0007420,GO:0007613,GO:0008021,GO:0014049,GO:0014059,GO:0016021,GO:0016192,GO:0017075,GO:0017156,GO:0017158,GO:0019905,GO:0030100,GO:0030276,GO:0030348,GO:0030424,GO:0030425,GO:0030667,GO:0031045,GO:0031338,GO:0031339,GO:0031982,GO:0033604,GO:0036477,GO:0042803,GO:0043005,GO:0043025,GO:0044306,GO:0045202,GO:0045955,GO:0046929,GO:0046982,GO:0048174,GO:0048471,GO:0050709,GO:0061782,GO:0061792,GO:0070382,GO:0071277,GO:0097449,GO:0098675,GO:0098978,GO:0098992,GO:0099066,GO:0099161,GO:0099183,GO:0099519,GO:1903861,GO:1905414,GO:1905415,GO:1905433,GO:1990742,GO:2000301 SNARE binding|phosphatidylserine binding|calcium ion binding|protein binding|phospholipid binding|calcium-dependent phospholipid binding|Golgi apparatus|plasma membrane|vesicle fusion|neurotransmitter secretion|brain development|memory|synaptic vesicle|positive regulation of glutamate secretion|regulation of dopamine secretion|integral component of membrane|vesicle-mediated transport|syntaxin-1 binding|calcium-ion regulated exocytosis|regulation of calcium ion-dependent exocytosis|syntaxin binding|regulation of endocytosis|clathrin binding|syntaxin-3 binding|axon|dendrite|secretory granule membrane|dense core granule|regulation of vesicle fusion|negative regulation of vesicle fusion|vesicle|negative regulation of catecholamine secretion|somatodendritic compartment|protein homodimerization activity|neuron projection|neuronal cell body|neuron projection terminus|synapse|negative regulation of calcium ion-dependent exocytosis|negative regulation of neurotransmitter secretion|protein heterodimerization activity|negative regulation of short-term neuronal synaptic plasticity|perinuclear region of cytoplasm|negative regulation of protein secretion|vesicle fusion with vesicle|secretory granule maturation|exocytic vesicle|cellular response to calcium ion|astrocyte projection|intrinsic component of neuronal dense core vesicle membrane|glutamatergic synapse|neuronal dense core vesicle|integral component of neuronal dense core vesicle membrane|regulation of presynaptic dense core granule exocytosis|trans-synaptic signaling by BDNF, modulating synaptic transmission|dense core granule cytoskeletal transport|positive regulation of dendrite extension|negative regulation of dense core granule exocytosis|positive regulation of dense core granule exocytosis|negative regulation of retrograde trans-synaptic signaling by neuropeptide|microvesicle|negative regulation of synaptic vesicle exocytosis Tbc1d30 3.0338439781205984 7.100448987228315 0.32277397204878605 0.049817183719545806 -4.327212724773438 0.028517499388505764 0.5738259084033145 Down 0.0 0.0 0.004261279878365386 0.01787571334919449 0.044778529564565364 299824 GO:0005096,GO:0005829,GO:0005886,GO:0005929,GO:0006886,GO:0031267,GO:0036064,GO:0043547,GO:0090630,GO:1902018 GTPase activator activity|cytosol|plasma membrane|cilium|intracellular protein transport|small GTPase binding|ciliary basal body|positive regulation of GTPase activity|activation of GTPase activity|negative regulation of cilium assembly Tepp 4.322381883469541 0.0 7.203969805782566 38.65900841658798 5.272732728535387 0.006676752761353099 0.31252341596299105 Up 0.18468248020083827 0.09401585563843556 0.224645557004422 0.0 0.0 291850 testis, prostate and placenta expressed GO:0019953 sexual reproduction Testin 3.8444580312958094 8.614255291455176 0.6645931911895654 0.0766947768300146 -3.70472786104292 0.0286022992008282 0.5747789262176902 Down 0.0040252556520379785 0.004098253974911494 0.0 0.04107891099878831 0.02881266299799098 286916 testin gene GO:0004197,GO:0005615,GO:0005764,GO:0006955,GO:0030054,GO:0051603 cysteine-type endopeptidase activity|extracellular space|lysosome|immune response|cell junction|proteolysis involved in cellular protein catabolic process Tmdd1 18.491523586381426 29.39749281391756 11.220877434690658 0.3813411477569244 -1.3908458846678344 0.03471984783332168 0.6092043700399861 Down 0.07610928821051484 0.09862304587466092 0.06059678834013772 0.20477098838529686 0.2051799238051548 120093738 Tmem37 7.490544632897885 15.710201832745627 2.010773166332726 0.1270551675443596 -2.9764730415030867 0.02206184031155945 0.5188448919281727 Down 0.0 0.10357830483359964 0.0 0.29416196856477056 0.2427348174241395 245953 transmembrane protein 37 GO:0005244,GO:0005262,GO:0016021,GO:0034765,GO:0070588 voltage-gated ion channel activity|calcium channel activity|integral component of membrane|regulation of ion transmembrane transport|calcium ion transmembrane transport Tnfsf8 4.5114165555492285 0.0 7.519027592582046 40.35729206706664 5.334757469220642 0.0058737277952590535 0.2937437877544372 Up 0.18736606666033925 0.19076396478457072 0.4740524660203959 0.0 0.0 683163 TNF superfamily member 8 GO:0005164,GO:0016021,GO:0043374,GO:0045944,GO:0050830 tumor necrosis factor receptor binding|integral component of membrane|CD8-positive, alpha-beta T cell differentiation|positive regulation of transcription by RNA polymerase II|defense response to Gram-positive bacterium rno04060 Cytokine-cytokine receptor interaction Trdn 5.9602450506004825 1.0152074640684017 9.256936774955204 9.120750611710069 3.189152558954774 0.04379542495612974 0.6518370958193755 Up 0.11135392780201987 0.050388151068183486 0.012039963032052028 0.0 0.012651875867722285 59299 triadin GO:0005102,GO:0005515,GO:0005783,GO:0005829,GO:0005886,GO:0006874,GO:0009617,GO:0010880,GO:0014070,GO:0014701,GO:0014808,GO:0014902,GO:0016021,GO:0016529,GO:0030314,GO:0030674,GO:0031122,GO:0033017,GO:0034704,GO:0042383,GO:0043231,GO:0044325,GO:0051280,GO:0051281,GO:0060047,GO:0060316,GO:0086036,GO:0090158,GO:1901846 signaling receptor binding|protein binding|endoplasmic reticulum|cytosol|plasma membrane|cellular calcium ion homeostasis|response to bacterium|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to organic cyclic compound|junctional sarcoplasmic reticulum membrane|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|myotube differentiation|integral component of membrane|sarcoplasmic reticulum|junctional membrane complex|protein-macromolecule adaptor activity|cytoplasmic microtubule organization|sarcoplasmic reticulum membrane|calcium channel complex|sarcolemma|intracellular membrane-bounded organelle|ion channel binding|negative regulation of release of sequestered calcium ion into cytosol|positive regulation of release of sequestered calcium ion into cytosol|heart contraction|positive regulation of ryanodine-sensitive calcium-release channel activity|regulation of cardiac muscle cell membrane potential|endoplasmic reticulum membrane organization|positive regulation of cell communication by electrical coupling involved in cardiac conduction rno04020,rno04260 Calcium signaling pathway|Cardiac muscle contraction Trhde 39.38913891696768 24.31995467826293 49.43526174277083 2.031963948526737 1.0228748057798192 0.03454842748362251 0.6089804904202715 Up 0.1784716463752959 0.15142353624923124 0.11578174566675935 0.09106776700687466 0.05474977967216119 366894 thyrotropin-releasing hormone degrading enzyme GO:0004177,GO:0005737,GO:0005886,GO:0006508,GO:0007165,GO:0008217,GO:0008237,GO:0008270,GO:0016021,GO:0042277,GO:0043171,GO:0070006 aminopeptidase activity|cytoplasm|plasma membrane|proteolysis|signal transduction|regulation of blood pressure|metallopeptidase activity|zinc ion binding|integral component of membrane|peptide binding|peptide catabolic process|metalloaminopeptidase activity Trim54 24.355685776024817 11.650872791784641 32.825561098851594 2.81788051600016 1.494610439671468 0.02196689970760228 0.5188448919281727 Up 0.8533057011760028 0.3861246516121432 0.6458360751158312 0.3096261050703851 0.1357319425568009 362708 tripartite motif-containing 54 GO:0005737,GO:0005874,GO:0005875,GO:0007026,GO:0007275,GO:0008017,GO:0008270,GO:0016567,GO:0030018,GO:0030154,GO:0061630 cytoplasm|microtubule|microtubule associated complex|negative regulation of microtubule depolymerization|multicellular organism development|microtubule binding|zinc ion binding|protein ubiquitination|Z disc|cell differentiation|ubiquitin protein ligase activity Trim72 78.2339865220263 48.18033171449561 98.2697563937134 2.0393780574622564 1.0281292452260349 0.010165719714842106 0.3806690116633436 Up 1.3286122491921124 1.1217568047905302 0.7673228357478051 0.3086573516128576 0.7400479066550716 365377 tripartite motif containing 72 GO:0001778,GO:0001786,GO:0003012,GO:0005737,GO:0006887,GO:0007517,GO:0008270,GO:0010832,GO:0016567,GO:0030659,GO:0031624,GO:0042383,GO:0042802,GO:0043161,GO:0043569,GO:0046627,GO:0051260,GO:0061630 plasma membrane repair|phosphatidylserine binding|muscle system process|cytoplasm|exocytosis|muscle organ development|zinc ion binding|negative regulation of myotube differentiation|protein ubiquitination|cytoplasmic vesicle membrane|ubiquitin conjugating enzyme binding|sarcolemma|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of insulin-like growth factor receptor signaling pathway|negative regulation of insulin receptor signaling pathway|protein homooligomerization|ubiquitin protein ligase activity Ttll11 11.510019421992347 4.562430327057312 16.141745485282367 3.5375566860021985 1.8227532659541392 0.042861431191519056 0.6486352009049089 Up 0.14774477010282022 0.10744580924758099 0.08900169885315873 0.02871959204932378 0.03597118270306263 689746 GO:0005524,GO:0018095,GO:0036064,GO:0051013 ATP binding|protein polyglutamylation|ciliary basal body|microtubule severing Ttn 255.35623817980306 125.21903538930948 342.11437337346524 2.7323966805488613 1.4501669446518348 6.192987922273888e-12 9.508094357067101e-09 Up 0.1023712641046896 0.0768263697084909 0.08150608117508569 0.0272091500454512 0.03626558276004353 84015 GO:0000794,GO:0001701,GO:0001756,GO:0002020,GO:0003007,GO:0003300,GO:0004674,GO:0004713,GO:0005509,GO:0005516,GO:0005865,GO:0006936,GO:0007076,GO:0007507,GO:0007512,GO:0008307,GO:0010628,GO:0010737,GO:0019899,GO:0019901,GO:0021591,GO:0030016,GO:0030017,GO:0030018,GO:0030240,GO:0030241,GO:0030506,GO:0031430,GO:0031433,GO:0031672,GO:0031674,GO:0035995,GO:0042802,GO:0042805,GO:0043056,GO:0043621,GO:0045214,GO:0045859,GO:0048769,GO:0050714,GO:0050790,GO:0051015,GO:0051371,GO:0051592,GO:0055002,GO:0055003,GO:0055008,GO:0055013,GO:0060048,GO:0060419,GO:0097493,GO:1901897 condensed nuclear chromosome|in utero embryonic development|somitogenesis|protease binding|heart morphogenesis|cardiac muscle hypertrophy|protein serine/threonine kinase activity|protein tyrosine kinase activity|calcium ion binding|calmodulin binding|striated muscle thin filament|muscle contraction|mitotic chromosome condensation|heart development|adult heart development|structural constituent of muscle|positive regulation of gene expression|protein kinase A signaling|enzyme binding|protein kinase binding|ventricular system development|myofibril|sarcomere|Z disc|skeletal muscle thin filament assembly|skeletal muscle myosin thick filament assembly|ankyrin binding|M band|telethonin binding|A band|I band|detection of muscle stretch|identical protein binding|actinin binding|forward locomotion|protein self-association|sarcomere organization|regulation of protein kinase activity|sarcomerogenesis|positive regulation of protein secretion|regulation of catalytic activity|actin filament binding|muscle alpha-actinin binding|response to calcium ion|striated muscle cell development|cardiac myofibril assembly|cardiac muscle tissue morphogenesis|cardiac muscle cell development|cardiac muscle contraction|heart growth|structural molecule activity conferring elasticity|regulation of relaxation of cardiac muscle rno05410,rno05414 Hypertrophic cardiomyopathy|Dilated cardiomyopathy Ugt1a8 5.465539282884366 13.179687249137736 0.32277397204878605 0.02683721710676553 -5.219621111173397 0.0016929748336813016 0.14520805933803926 Down 0.0 0.0 0.011686005411495741 0.147065451387224 0.17191900444133398 301595 UDP glucuronosyltransferase family 1 member A8 GO:0004857,GO:0005496,GO:0005504,GO:0005783,GO:0005789,GO:0006631,GO:0008144,GO:0008202,GO:0015020,GO:0016020,GO:0016021,GO:0017144,GO:0018411,GO:0019899,GO:0042803,GO:0043086,GO:0045922,GO:0046226,GO:0046982,GO:0051552,GO:0052695,GO:0052696,GO:0052697,GO:0071407,GO:1904224,GO:2001030 enzyme inhibitor activity|steroid binding|fatty acid binding|endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid metabolic process|drug binding|steroid metabolic process|glucuronosyltransferase activity|membrane|integral component of membrane|drug metabolic process|protein glucuronidation|enzyme binding|protein homodimerization activity|negative regulation of catalytic activity|negative regulation of fatty acid metabolic process|coumarin catabolic process|protein heterodimerization activity|flavone metabolic process|cellular glucuronidation|flavonoid glucuronidation|xenobiotic glucuronidation|cellular response to organic cyclic compound|negative regulation of glucuronosyltransferase activity|negative regulation of cellular glucuronidation rno00040,rno00053,rno00140,rno00830,rno00860,rno00980,rno00982,rno00983,rno04976,rno05204 Pentose and glucuronate interconversions|Ascorbate and aldarate metabolism|Steroid hormone biosynthesis|Retinol metabolism|Porphyrin and chlorophyll metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Bile secretion|Chemical carcinogenesis Unc45b 50.237292144243966 26.860974969059182 65.82150359436716 2.4503415211750306 1.2929828417044598 0.004631769015072099 0.2595312032423429 Up 0.7139806902207304 0.3747055594392944 0.3796231810209252 0.21032854468914675 0.18816837389236202 303373 unc-45 myosin chaperone B GO:0005829,GO:0007517,GO:0030154,GO:0051879,GO:0061077 cytosol|muscle organ development|cell differentiation|Hsp90 protein binding|chaperone-mediated protein folding Vit 8.866476582532222 17.734613499631934 2.9543853044657475 0.1667363364555268 -2.584359553180732 0.016885179181209804 0.4647211015890029 Down 0.0 0.020898422839460445 0.02496779829000049 0.10997472093570893 0.07346289641259919 313831 GO:0005539,GO:0005614,GO:0010811,GO:0021510,GO:0030198,GO:0031012,GO:0062023 glycosaminoglycan binding|interstitial matrix|positive regulation of cell-substrate adhesion|spinal cord development|extracellular matrix organization|extracellular matrix|collagen-containing extracellular matrix Wfikkn2 20.665793054515085 33.446316147690176 12.145444325731685 0.3633955583083133 -1.4603873089029262 0.020216186659403456 0.5001009382788348 Down 0.057085287644754526 0.06393258713112944 0.08888046104309796 0.21555165974250048 0.16928328682622867 287631 GO:0001501,GO:0004857,GO:0004867,GO:0005576,GO:0005615,GO:0007179,GO:0008191,GO:0010951,GO:0030512,GO:0032091,GO:0043392,GO:0048019,GO:0050431,GO:0055001,GO:0060021,GO:2000272 skeletal system development|enzyme inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|transforming growth factor beta receptor signaling pathway|metalloendopeptidase inhibitor activity|negative regulation of endopeptidase activity|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of protein binding|negative regulation of DNA binding|receptor antagonist activity|transforming growth factor beta binding|muscle cell development|roof of mouth development|negative regulation of signaling receptor activity Wnt5b 80.47180830690412 115.06696074862543 57.40837334575654 0.4985995433355368 -1.0040465334134605 0.0033962588615431212 0.22378867940459884 Down 0.4664257012837732 0.8310476431003272 0.5467235590376637 1.1467298442689484 1.3116170638818867 282582 Wnt family member 5B GO:0002062,GO:0005102,GO:0005109,GO:0005125,GO:0005615,GO:0009986,GO:0030182,GO:0030335,GO:0031012,GO:0042060,GO:0045165,GO:0045600,GO:0060070,GO:0090090 chondrocyte differentiation|signaling receptor binding|frizzled binding|cytokine activity|extracellular space|cell surface|neuron differentiation|positive regulation of cell migration|extracellular matrix|wound healing|cell fate commitment|positive regulation of fat cell differentiation|canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway rno04150,rno04310,rno04360,rno04390,rno04550,rno04916,rno04934,rno05010,rno05022,rno05165,rno05200,rno05205,rno05217,rno05224,rno05225,rno05226 mTOR signaling pathway|Wnt signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Alzheimer disease|Pathways of neurodegeneration - multiple diseases|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer Ybx2 8.240974319203671 15.695193679619384 3.2714947455931918 0.2088152511522292 -2.2597010096167005 0.04950278202829767 0.6853658499050183 Down 0.017206350044435013 0.052555165603672085 0.1004620709587621 0.4741087509994558 0.07037860209376061 303250 Y box binding protein 2 GO:0003676,GO:0003682,GO:0003729,GO:0003730,GO:0005634,GO:0005737,GO:0005844,GO:0007286,GO:0008289,GO:0010468,GO:0017148,GO:0043021,GO:0045182,GO:0048255,GO:0048477,GO:0048599,GO:0051100,GO:0120162,GO:1990904 nucleic acid binding|chromatin binding|mRNA binding|mRNA 3'-UTR binding|nucleus|cytoplasm|polysome|spermatid development|lipid binding|regulation of gene expression|negative regulation of translation|ribonucleoprotein complex binding|translation regulator activity|mRNA stabilization|oogenesis|oocyte development|negative regulation of binding|positive regulation of cold-induced thermogenesis|ribonucleoprotein complex CSD