do 20/09/2018 09:45 ;; 1. Based on: 1134 ;; COMMENT: $PROBLEM Remove IIV_Q2 $INPUT ID DID TIME DV AMT RATE EVID MDV PMA PNA WGT HGT M1F2 SCR BURN STDY $DATA data.csv IGNORE=@ IGNORE(DID.EQ.855,DID.EQ.882,DID.EQ.890,DID.EQ.907,DID.EQ.929) IGNORE(DID.EQ.1038,DID.EQ.1044,DID.EQ.1683,DID.EQ.1801,DID.EQ.1987) $SUBROUTINE ADVAN3 TRANS4 $PK PMA_R = 35+(40/52) mPNA = PNA IF(mPNA.LT.0) mPNA = (PMA-40/52)*365 GA = 40 IF(PNA.GT.0) GA = (PMA*365 - PNA)/7 HEEL = 0 IF(STDY.EQ.13) HEEL = 1 CANCER = 0 IF(STDY.EQ.10) CANCER = 1 DEG50 = EXP(THETA(5)) MAT50 = EXP(THETA(6)) GAM = EXP(THETA(7)) EXPO2 = EXP(THETA(9)) GAM2 = -EXP(THETA(8)) LnSCRstd = -1.22839 + LOG10(PMA)*0.67190 + 6.27017*EXP(-3.10940*PMA) SCRstd = EXP(LnSCRstd) Fsize = WGT/70 Fmat = PMA**GAM/(PMA**GAM+MAT50**GAM) Fmat_R = PMA_R**GAM/(PMA_R**GAM+MAT50**GAM) Fage = PMA**GAM2/(PMA**GAM2+DEG50**GAM2) Fage_R = PMA_R**GAM2/(PMA_R**GAM2+DEG50**GAM2) Fscr = EXP(-EXPO2*(SCR-SCRstd)) ; For a man of 35 yr, 70 kg and GA 40 wks, SCRstd = 0.84 mg/dL TVV1 = EXP(THETA(2)) * Fsize * (1-HEEL*THETA(10)) V1 = TVV1 * EXP(ETA(2)) TVV2 = EXP(THETA(3)) * Fsize V2 = TVV2 * EXP(ETA(3)) RV1 = EXP(THETA(2)) TVCL = EXP(THETA(1)) * (V1/RV1)**0.75 * Fmat/Fmat_R * Fage/Fage_R * Fscr * (1+CANCER*THETA(12)) CL = TVCL * EXP(ETA(1)) RV2 = EXP(THETA(3)) TVQ = EXP(THETA(4)) * (V2/RV2)**0.75 * (1-HEEL*THETA(11)) Q = TVQ * EXP(ETA(4)) S1=V1 $ERROR IPRED = F Y = IPRED*(1+EPS(1)) + EPS(2) IRES = DV-IPRED ; If error variance is estimated through THETA, then THETA reflects the error SD! ; SIGMA(1,1) can be used in $ERROR and always defines the error variance ! $THETA (1,1.67,2.5) ; CLstd; L/h ;;llp (2.77,3.75,4.5) ; V1std; L ;;llp (2.78,3.73,4.5) ; V2std; L ;;llp (0.5,1.17,2.5) ; Qstd; L/h ;;llp (3.5,4.12,4.8) ; DEG50; ;;llp (-0.69,-0.113,0.40) ; MAT50; ;;llp (-0.69,1.06,1.5) ; GAM; ;llp (-0.69,0.806,1.5) ; GAM2; ;llp (-1.5,-0.436,-0.01) ; SCR~CL; ;llp (0,0.313,1) ; HEEL ~ V1; ;llp (0,0.595,1) ; HEEL ~ Q2; ;llp (0,0.293,1.5) ; CANCER ~ CL; ;llp $OMEGA 0.0749 ; IIV_CL ; ;llp 0.0721 ; IIV_V1 ; ;llp 0.672 ; IIV_V2 ; ;llp 0 FIX ; IIV_Q $SIGMA 0.046 ; Prop. error ; ;llp 1.52 ; Add. error ; ;llp $ESTIMATION SIG=3 SIGL=9 MAX=6000 METHOD=1 INTERACT SORT NOABORT POSTHOC PRINT=1 ;$COV PRINT=E SIGL=12 $TABLE ID DID TIME DV AMT RATE EVID MDV IPRED PRED RES IRES CWRES NPDE CL V1 Q V2 DEG50 GAM2 MAT50 GAM EXPO2 ETA1 ETA2 ETA3 ETA4 Fsize Fmat Fage Fscr PMA PNA WGT HGT M1F2 SCR BURN STDY NOAPPEND NOPRINT ONEHEADER FILE=sdtab1137 WRESCHOL NM-TRAN MESSAGES WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1 (WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION. (WARNING 97) A RANDOM QUANTITY IS RAISED TO A POWER. IF THE RESULT AFFECTS THE VALUE OF THE OBJECTIVE FUNCTION, THE USER SHOULD ENSURE THAT THE RANDOM QUANTITY IS NEVER 0 WHEN THE POWER IS < 1. License Registered to: University Medical Center Groningen Expiration Date: 14 JUL 2019 Current Date: 20 SEP 2018 Days until program expires : 299 1NONLINEAR MIXED EFFECTS MODEL PROGRAM (NONMEM) VERSION 7.3.0 ORIGINALLY DEVELOPED BY STUART BEAL, LEWIS SHEINER, AND ALISON BOECKMANN CURRENT DEVELOPERS ARE ROBERT BAUER, ICON DEVELOPMENT SOLUTIONS, AND ALISON BOECKMANN. IMPLEMENTATION, EFFICIENCY, AND STANDARDIZATION PERFORMED BY NOUS INFOSYSTEMS. PROBLEM NO.: 1 Remove IIV_Q2 0DATA CHECKOUT RUN: NO DATA SET LOCATED ON UNIT NO.: 2 THIS UNIT TO BE REWOUND: NO NO. OF DATA RECS IN DATA SET: 34633 NO. OF DATA ITEMS IN DATA SET: 16 ID DATA ITEM IS DATA ITEM NO.: 1 DEP VARIABLE IS DATA ITEM NO.: 4 MDV DATA ITEM IS DATA ITEM NO.: 8 0INDICES PASSED TO SUBROUTINE PRED: 7 3 5 6 0 0 0 0 0 0 0 0LABELS FOR DATA ITEMS: ID DID TIME DV AMT RATE EVID MDV PMA PNA WGT HGT M1F2 SCR BURN STDY 0(NONBLANK) LABELS FOR PRED-DEFINED ITEMS: DEG50 MAT50 GAM EXPO2 GAM2 Fsize Fmat Fage Fscr V1 V2 CL Q IPRED IRES 0FORMAT FOR DATA: (3(4E18.0/),4E18.0) TOT. NO. OF OBS RECS: 8253 TOT. NO. OF INDIVIDUALS: 2544 0LENGTH OF THETA: 12 0DEFAULT THETA BOUNDARY TEST OMITTED: NO 0OMEGA HAS BLOCK FORM: 1 0 2 0 0 3 0 0 0 4 0DEFAULT OMEGA BOUNDARY TEST OMITTED: NO 0SIGMA HAS SIMPLE DIAGONAL FORM WITH DIMENSION: 2 0DEFAULT SIGMA BOUNDARY TEST OMITTED: NO 0INITIAL ESTIMATE OF THETA: LOWER BOUND INITIAL EST UPPER BOUND 0.1000E+01 0.1670E+01 0.2500E+01 0.2770E+01 0.3750E+01 0.4500E+01 0.2780E+01 0.3730E+01 0.4500E+01 0.5000E+00 0.1170E+01 0.2500E+01 0.3500E+01 0.4120E+01 0.4800E+01 -0.6900E+00 -0.1130E+00 0.4000E+00 -0.6900E+00 0.1060E+01 0.1500E+01 -0.6900E+00 0.8060E+00 0.1500E+01 -0.1500E+01 -0.4360E+00 -0.1000E-01 0.0000E+00 0.3130E+00 0.1000E+01 0.0000E+00 0.5950E+00 0.1000E+01 0.0000E+00 0.2930E+00 0.1500E+01 0INITIAL ESTIMATE OF OMEGA: BLOCK SET NO. BLOCK FIXED 1 NO 0.7490E-01 2 NO 0.7210E-01 3 NO 0.6720E+00 4 YES 0.0000E+00 0INITIAL ESTIMATE OF SIGMA: 0.4600E-01 0.0000E+00 0.1520E+01 0TABLES STEP OMITTED: NO NO. OF TABLES: 1 SEED NUMBER (SEED): 11456 RANMETHOD: MC SAMPLES (ESEED): 300 WRES SQUARE ROOT TYPE (WRESCHOL): CHOLESKY 0-- TABLE 1 -- 04 COLUMNS APPENDED: NO PRINTED: NO HEADERS: ONE FILE TO BE FORWARDED: NO FORMAT: S1PE11.4 LFORMAT: RFORMAT: 0USER-CHOSEN ITEMS: ID DID TIME DV AMT RATE EVID MDV IPRED PRED RES IRES CWRES NPDE CL V1 Q V2 DEG50 GAM2 MAT50 GAM EXPO2 ETA1 ETA2 ETA3 ETA4 Fsize Fmat Fage Fscr PMA PNA WGT HGT M1F2 SCR BURN STDY 1DOUBLE PRECISION PREDPP VERSION 7.3.0 TWO COMPARTMENT MODEL (ADVAN3) 0MAXIMUM NO. OF BASIC PK PARAMETERS: 4 0BASIC PK PARAMETERS (AFTER TRANSLATION): BASIC PK PARAMETER NO. 1: ELIMINATION RATE (K) BASIC PK PARAMETER NO. 2: CENTRAL-TO-PERIPH. RATE (K12) BASIC PK PARAMETER NO. 3: PERIPH.-TO-CENTRAL RATE (K21) TRANSLATOR WILL CONVERT PARAMETERS CL, V1, Q, V2 TO K, K12, K21 (TRANS4) 0COMPARTMENT ATTRIBUTES COMPT. NO. FUNCTION INITIAL ON/OFF DOSE DEFAULT DEFAULT STATUS ALLOWED ALLOWED FOR DOSE FOR OBS. 1 CENTRAL ON NO YES YES YES 2 PERIPH. ON NO YES NO NO 3 OUTPUT OFF YES NO NO NO 1 ADDITIONAL PK PARAMETERS - ASSIGNMENT OF ROWS IN GG COMPT. NO. INDICES SCALE BIOAVAIL. ZERO-ORDER ZERO-ORDER ABSORB FRACTION RATE DURATION LAG 1 5 * * * * 2 * * * * * 3 * - - - - - PARAMETER IS NOT ALLOWED FOR THIS MODEL * PARAMETER IS NOT SUPPLIED BY PK SUBROUTINE; WILL DEFAULT TO ONE IF APPLICABLE 0DATA ITEM INDICES USED BY PRED ARE: EVENT ID DATA ITEM IS DATA ITEM NO.: 7 TIME DATA ITEM IS DATA ITEM NO.: 3 DOSE AMOUNT DATA ITEM IS DATA ITEM NO.: 5 DOSE RATE DATA ITEM IS DATA ITEM NO.: 6 0PK SUBROUTINE CALLED WITH EVERY EVENT RECORD. PK SUBROUTINE NOT CALLED AT NONEVENT (ADDITIONAL OR LAGGED) DOSE TIMES. 0ERROR SUBROUTINE CALLED WITH EVERY EVENT RECORD. #PARA: PARAFILE=fpi_psn.pnm, PROTOCOL=FPI, NODES= 20 1 #TBLN: 1 #METH: First Order Conditional Estimation with Interaction ESTIMATION STEP OMITTED: NO ANALYSIS TYPE: POPULATION CONDITIONAL ESTIMATES USED: YES CENTERED ETA: NO EPS-ETA INTERACTION: YES LAPLACIAN OBJ. FUNC.: NO NO. OF FUNCT. EVALS. ALLOWED: 6000 NO. OF SIG. FIGURES REQUIRED: 3 INTERMEDIATE PRINTOUT: YES ESTIMATE OUTPUT TO MSF: NO ABORT WITH PRED EXIT CODE 1: NO IND. OBJ. FUNC. VALUES SORTED: YES NUMERICAL DERIVATIVE FILE REQUEST (NUMDER): NONE MAP (ETAHAT) ESTIMATION METHOD (OPTMAP): 0 ETA HESSIAN EVALUATION METHOD (ETADER): 0 INITIAL ETA FOR MAP ESTIMATION (MCETA): 0 SIGDIGITS FOR MAP ESTIMATION (SIGLO): 9 GRADIENT SIGDIGITS OF FIXED EFFECTS PARAMETERS (SIGL): 9 EXCLUDE TITLE (NOTITLE): NO EXCLUDE COLUMN LABELS (NOLABEL): NO NOPRIOR SETTING (NOPRIOR): OFF NOCOV SETTING (NOCOV): OFF DERCONT SETTING (DERCONT): OFF ABSOLUTE TOLERANCE-ADVAN 9,13 ONLY(ATOL):-100 FINAL ETA RE-EVALUATION (FNLETA): ON EXCLUDE NON-INFLUENTIAL (NON-INFL.) ETAS IN SHRINKAGE (ETASTYPE): NO NON-INFL. ETA CORRECTION (NONINFETA): OFF FORMAT FOR ADDITIONAL FILES (FORMAT): S1PE12.5 PARAMETER ORDER FOR OUTPUTS (ORDER): TSOL ADDITIONAL CONVERGENCE TEST (CTYPE=4)?: NO EM OR BAYESIAN METHOD USED: NONE THE FOLLOWING LABELS ARE EQUIVALENT PRED=PREDI RES=RESI WRES=WRESI IWRS=IWRESI IPRD=IPREDI IRS=IRESI MONITORING OF SEARCH: 0ITERATION NO.: 0 OBJECTIVE VALUE: 33839.6567164996 NO. OF FUNC. EVALS.: 16 CUMULATIVE NO. OF FUNC. EVALS.: 16 NPARAMETR: 1.6700E+00 3.7500E+00 3.7300E+00 1.1700E+00 4.1200E+00 -1.1300E-01 1.0600E+00 8.0600E-01 -4.3600E-01 3.1300E-01 5.9500E-01 2.9300E-01 7.4900E-02 7.2100E-02 6.7200E-01 4.6000E-02 1.5200E+00 PARAMETER: 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 GRADIENT: 4.8808E+01 -3.7399E+01 5.0678E+00 -9.4485E+00 2.1975E+01 -6.2262E+00 -3.7282E+00 -2.2995E+01 2.5521E-01 1.7124E+00 1.3073E+00 3.5928E+00 4.8585E-01 5.2674E+00 7.2285E-01 -1.5532E+00 3.8416E-01 0ITERATION NO.: 1 OBJECTIVE VALUE: 33839.6210612369 NO. OF FUNC. EVALS.: 18 CUMULATIVE NO. OF FUNC. EVALS.: 34 NPARAMETR: 1.6644E+00 3.7549E+00 3.7293E+00 1.1713E+00 4.1178E+00 -1.1248E-01 1.0604E+00 8.0935E-01 -4.3602E-01 3.1289E-01 5.9490E-01 2.9274E-01 7.4878E-02 7.1867E-02 6.7170E-01 4.6044E-02 1.5196E+00 PARAMETER: 8.5000E-02 1.1149E-01 9.8443E-02 1.0290E-01 9.3246E-02 1.0191E-01 1.0115E-01 1.0707E-01 9.9922E-02 9.9474E-02 9.9598E-02 9.8896E-02 9.9851E-02 9.8381E-02 9.9778E-02 1.0048E-01 9.9882E-02 GRADIENT: -6.0813E+01 1.5346E+01 -9.5490E+00 6.3935E+00 -1.1257E+01 2.9132E+01 1.6306E+01 2.5422E+01 -1.2372E-01 1.3725E+00 -1.2069E+00 -3.7235E+00 -8.2958E-01 -1.4225E+00 -2.3457E-01 1.0419E+01 2.0863E+00 0ITERATION NO.: 2 OBJECTIVE VALUE: 33839.3429233307 NO. OF FUNC. EVALS.: 18 CUMULATIVE NO. OF FUNC. EVALS.: 52 NPARAMETR: 1.6692E+00 3.7535E+00 3.7302E+00 1.1707E+00 4.1186E+00 -1.1414E-01 1.0592E+00 8.0682E-01 -4.3602E-01 3.1282E-01 5.9496E-01 2.9292E-01 7.4904E-02 7.1910E-02 6.7177E-01 4.5843E-02 1.5183E+00 PARAMETER: 9.7750E-02 1.0828E-01 1.0044E-01 1.0156E-01 9.5606E-02 9.5806E-02 9.7727E-02 1.0174E-01 9.9948E-02 9.9186E-02 9.9851E-02 9.9676E-02 1.0002E-01 9.8679E-02 9.9827E-02 9.8293E-02 9.9445E-02 GRADIENT: 3.0860E+01 -1.2001E+01 3.0954E+00 -4.1541E+00 6.7864E+00 -1.6060E+01 -9.4779E+00 -1.3535E+01 -1.3945E-01 -7.5228E-01 8.3113E-01 1.5748E+00 -2.7126E+00 -2.3615E+00 -1.7605E+00 -2.6699E+01 -4.5511E+00 0ITERATION NO.: 3 OBJECTIVE VALUE: 33839.3343175884 NO. OF FUNC. EVALS.: 20 CUMULATIVE NO. OF FUNC. EVALS.: 72 NPARAMETR: 1.6693E+00 3.7536E+00 3.7303E+00 1.1707E+00 4.1186E+00 -1.1417E-01 1.0592E+00 8.0677E-01 -4.3601E-01 3.1282E-01 5.9496E-01 2.9293E-01 7.4929E-02 7.1935E-02 6.7190E-01 4.5942E-02 1.5188E+00 PARAMETER: 9.8111E-02 1.0841E-01 1.0059E-01 1.0157E-01 9.5616E-02 9.5701E-02 9.7694E-02 1.0162E-01 9.9959E-02 9.9181E-02 9.9847E-02 9.9715E-02 1.0020E-01 9.8852E-02 9.9929E-02 9.9372E-02 9.9618E-02 GRADIENT: 3.2244E+01 -1.2701E+01 3.2294E+00 -4.3904E+00 6.9372E+00 -1.6901E+01 -9.9577E+00 -1.4115E+01 -1.0598E-01 -7.8653E-01 8.8526E-01 1.6457E+00 -1.2099E+00 -1.1457E+00 -9.4351E-01 -1.2598E+01 -1.7105E+00 0ITERATION NO.: 4 OBJECTIVE VALUE: 33839.3301519724 NO. OF FUNC. EVALS.: 20 CUMULATIVE NO. OF FUNC. EVALS.: 92 NPARAMETR: 1.6695E+00 3.7543E+00 3.7306E+00 1.1709E+00 4.1185E+00 -1.1409E-01 1.0593E+00 8.0675E-01 -4.3599E-01 3.1283E-01 5.9494E-01 2.9297E-01 7.4986E-02 7.2012E-02 6.7226E-01 4.5943E-02 1.5179E+00 PARAMETER: 9.8782E-02 1.1007E-01 1.0143E-01 1.0191E-01 9.5384E-02 9.5976E-02 9.8043E-02 1.0159E-01 1.0002E-01 9.9189E-02 9.9760E-02 9.9886E-02 1.0057E-01 9.9388E-02 1.0020E-01 9.9377E-02 9.9301E-02 GRADIENT: 3.3040E+01 -9.0267E+00 3.5222E+00 -3.5986E+00 7.6683E+00 -1.6250E+01 -9.5480E+00 -1.4493E+01 -1.9540E-01 -1.0548E+00 6.9813E-01 1.7449E+00 1.4607E-02 -5.8788E-01 -6.1809E-01 -1.3593E+01 -2.1343E+00 0ITERATION NO.: 5 OBJECTIVE VALUE: 33838.1222051327 NO. OF FUNC. EVALS.: 18 CUMULATIVE NO. OF FUNC. EVALS.: 110 NPARAMETR: 1.6722E+00 3.7549E+00 3.7417E+00 1.1707E+00 4.1112E+00 -1.1362E-01 1.0620E+00 8.1022E-01 -4.3480E-01 3.1393E-01 5.9490E-01 2.9405E-01 7.3694E-02 7.3374E-02 6.7721E-01 4.6084E-02 1.4937E+00 PARAMETER: 1.0584E-01 1.1157E-01 1.2765E-01 1.0154E-01 7.2892E-02 9.7735E-02 1.0574E-01 1.0892E-01 1.0394E-01 1.0431E-01 9.9565E-02 1.0445E-01 9.1886E-02 1.0876E-01 1.0386E-01 1.0092E-01 9.1271E-02 GRADIENT: 3.8301E+01 -1.1685E+01 1.0624E+01 -4.8794E+00 -7.0313E+00 -2.7188E+01 -1.4925E+01 -8.0809E+00 -3.3526E+00 -4.8214E-01 1.4655E+00 2.5608E+00 -1.0641E+01 8.7994E+00 -2.3765E+00 -1.0580E+01 -9.3355E+00 0ITERATION NO.: 6 OBJECTIVE VALUE: 33838.1204986579 NO. OF FUNC. EVALS.: 20 CUMULATIVE NO. OF FUNC. EVALS.: 130 NPARAMETR: 1.6723E+00 3.7548E+00 3.7421E+00 1.1707E+00 4.1111E+00 -1.1346E-01 1.0622E+00 8.1018E-01 -4.3468E-01 3.1398E-01 5.9489E-01 2.9410E-01 7.3705E-02 7.3354E-02 6.7757E-01 4.6083E-02 1.4939E+00 PARAMETER: 1.0609E-01 1.1133E-01 1.2861E-01 1.0149E-01 7.2590E-02 9.8295E-02 1.0635E-01 1.0883E-01 1.0435E-01 1.0456E-01 9.9534E-02 1.0465E-01 9.1960E-02 1.0862E-01 1.0413E-01 1.0090E-01 9.1337E-02 GRADIENT: 3.8979E+01 -1.2432E+01 1.1373E+01 -5.0427E+00 -6.0600E+00 -2.5755E+01 -1.4055E+01 -8.3824E+00 -3.4722E+00 -2.7480E-01 1.4233E+00 2.6836E+00 -1.0527E+01 8.8720E+00 -9.1852E-01 -1.1416E+01 -9.3828E+00 0ITERATION NO.: 7 OBJECTIVE VALUE: 33838.1168818598 NO. OF FUNC. EVALS.: 18 CUMULATIVE NO. OF FUNC. EVALS.: 148 NPARAMETR: 1.6723E+00 3.7548E+00 3.7431E+00 1.1707E+00 4.1106E+00 -1.1338E-01 1.0627E+00 8.0988E-01 -4.3406E-01 3.1412E-01 5.9487E-01 2.9423E-01 7.3810E-02 7.3143E-02 6.7592E-01 4.6082E-02 1.4958E+00 PARAMETER: 1.0632E-01 1.1141E-01 1.3078E-01 1.0149E-01 7.1003E-02 9.8605E-02 1.0756E-01 1.0821E-01 1.0640E-01 1.0521E-01 9.9447E-02 1.0522E-01 9.2671E-02 1.0718E-01 1.0291E-01 1.0089E-01 9.1986E-02 GRADIENT: 3.8878E+01 -1.1983E+01 1.1133E+01 -4.9221E+00 -6.8203E+00 -2.5617E+01 -1.3836E+01 -7.9162E+00 -2.6945E+00 -1.3324E-01 1.4116E+00 2.7212E+00 -9.8475E+00 7.0315E+00 -3.7768E+00 -1.0436E+01 -8.5790E+00 0ITERATION NO.: 8 OBJECTIVE VALUE: 33838.1133463018 NO. OF FUNC. EVALS.: 18 CUMULATIVE NO. OF FUNC. EVALS.: 166 NPARAMETR: 1.6720E+00 3.7549E+00 3.7435E+00 1.1707E+00 4.1104E+00 -1.1358E-01 1.0628E+00 8.0927E-01 -4.3359E-01 3.1417E-01 5.9485E-01 2.9430E-01 7.3877E-02 7.3123E-02 6.7675E-01 4.6068E-02 1.4970E+00 PARAMETER: 1.0546E-01 1.1147E-01 1.3183E-01 1.0152E-01 7.0260E-02 9.7877E-02 1.0787E-01 1.0691E-01 1.0792E-01 1.0544E-01 9.9388E-02 1.0553E-01 9.3123E-02 1.0705E-01 1.0352E-01 1.0074E-01 9.2385E-02 GRADIENT: 3.8192E+01 -1.1832E+01 1.1722E+01 -4.9061E+00 -7.7717E+00 -2.7160E+01 -1.4682E+01 -7.8441E+00 -2.4383E+00 -1.6668E-01 1.4389E+00 2.5244E+00 -8.6891E+00 7.1035E+00 -1.8090E+00 -1.1424E+01 -8.3013E+00 0ITERATION NO.: 9 OBJECTIVE VALUE: 33838.1058416520 NO. OF FUNC. EVALS.: 18 CUMULATIVE NO. OF FUNC. EVALS.: 184 NPARAMETR: 1.6714E+00 3.7550E+00 3.7441E+00 1.1707E+00 4.1103E+00 -1.1373E-01 1.0633E+00 8.0738E-01 -4.3261E-01 3.1425E-01 5.9481E-01 2.9455E-01 7.3689E-02 7.3242E-02 6.7624E-01 4.6079E-02 1.4968E+00 PARAMETER: 1.0371E-01 1.1174E-01 1.3315E-01 1.0164E-01 6.9949E-02 9.7295E-02 1.0931E-01 1.0291E-01 1.1116E-01 1.0583E-01 9.9212E-02 1.0656E-01 9.1849E-02 1.0786E-01 1.0315E-01 1.0085E-01 9.2305E-02 GRADIENT: 3.7516E+01 -1.1108E+01 1.1703E+01 -4.8056E+00 -6.2001E+00 -2.6298E+01 -1.4101E+01 -9.0771E+00 -1.2508E+00 -8.6367E-02 1.4177E+00 2.4313E+00 -1.2021E+01 7.4372E+00 -2.8595E+00 -1.0368E+01 -8.3388E+00 0ITERATION NO.: 10 OBJECTIVE VALUE: 33838.1002074844 NO. OF FUNC. EVALS.: 19 CUMULATIVE NO. OF FUNC. EVALS.: 203 NPARAMETR: 1.6711E+00 3.7547E+00 3.7440E+00 1.1707E+00 4.1100E+00 -1.1376E-01 1.0637E+00 8.0639E-01 -4.3243E-01 3.1426E-01 5.9477E-01 2.9481E-01 7.3852E-02 7.3408E-02 6.7545E-01 4.6075E-02 1.4947E+00 PARAMETER: 1.0293E-01 1.1114E-01 1.3292E-01 1.0168E-01 6.9195E-02 9.7218E-02 1.1045E-01 1.0083E-01 1.1176E-01 1.0587E-01 9.9066E-02 1.0764E-01 9.2954E-02 1.0899E-01 1.0256E-01 1.0082E-01 9.1605E-02 GRADIENT: 3.6619E+01 -1.2638E+01 1.1103E+01 -4.9129E+00 -5.6539E+00 -2.5182E+01 -1.3414E+01 -9.2035E+00 -8.9778E-01 8.7616E-02 1.4340E+00 2.5178E+00 -7.9268E+00 1.0220E+01 -4.2915E+00 -1.0229E+01 -8.9511E+00 0ITERATION NO.: 11 OBJECTIVE VALUE: 33838.0411207696 NO. OF FUNC. EVALS.: 17 CUMULATIVE NO. OF FUNC. EVALS.: 220 NPARAMETR: 1.6700E+00 3.7546E+00 3.7416E+00 1.1712E+00 4.1075E+00 -1.1402E-01 1.0665E+00 7.9998E-01 -4.3346E-01 3.1394E-01 5.9441E-01 2.9703E-01 7.3980E-02 7.2869E-02 6.7831E-01 4.6145E-02 1.4856E+00 PARAMETER: 1.0006E-01 1.1078E-01 1.2731E-01 1.0267E-01 6.1566E-02 9.6251E-02 1.1858E-01 8.7338E-02 1.0837E-01 1.0436E-01 9.7539E-02 1.1700E-01 9.3818E-02 1.0531E-01 1.0467E-01 1.0158E-01 8.8544E-02 GRADIENT: 3.4119E+01 -1.1366E+01 9.4756E+00 -4.0039E+00 -5.7855E+00 -2.3362E+01 -1.1866E+01 -9.5830E+00 -1.7058E+00 -4.0042E-02 1.0869E+00 3.2435E+00 -7.8202E+00 6.3472E+00 -2.0904E+00 -7.9825E+00 -1.0512E+01 0ITERATION NO.: 12 OBJECTIVE VALUE: 33838.0029270372 NO. OF FUNC. EVALS.: 17 CUMULATIVE NO. OF FUNC. EVALS.: 237 NPARAMETR: 1.6695E+00 3.7548E+00 3.7398E+00 1.1707E+00 4.1060E+00 -1.1405E-01 1.0684E+00 7.9649E-01 -4.3489E-01 3.1348E-01 5.9423E-01 2.9838E-01 7.3872E-02 7.3179E-02 6.7850E-01 4.5964E-02 1.5145E+00 PARAMETER: 9.8688E-02 1.1128E-01 1.2304E-01 1.0157E-01 5.6777E-02 9.6124E-02 1.2394E-01 8.0004E-02 1.0365E-01 1.0225E-01 9.6820E-02 1.2265E-01 9.3093E-02 1.0743E-01 1.0482E-01 9.9609E-02 9.8174E-02 GRADIENT: 3.1796E+01 -9.8540E+00 7.9763E+00 -3.6530E+00 -5.4558E+00 -2.0455E+01 -9.8255E+00 -9.4008E+00 -2.8610E+00 -3.5561E-01 7.2805E-01 3.7768E+00 -7.3577E+00 8.2329E+00 -2.1832E+00 -8.5196E+00 -2.6318E+00 0ITERATION NO.: 13 OBJECTIVE VALUE: 33837.7651410360 NO. OF FUNC. EVALS.: 18 CUMULATIVE NO. OF FUNC. EVALS.: 255 NPARAMETR: 1.6676E+00 3.7558E+00 3.7389E+00 1.1645E+00 4.1112E+00 -1.1421E-01 1.0662E+00 7.9995E-01 -4.3554E-01 3.1203E-01 5.9544E-01 2.9554E-01 7.4388E-02 7.2286E-02 6.7934E-01 4.6002E-02 1.5149E+00 PARAMETER: 9.3495E-02 1.1375E-01 1.2087E-01 8.7523E-02 7.2765E-02 9.5558E-02 1.1775E-01 8.7263E-02 1.0151E-01 9.5489E-02 1.0183E-01 1.1075E-01 9.6570E-02 1.0129E-01 1.0543E-01 1.0003E-01 9.8327E-02 GRADIENT: 1.6979E+01 -3.6367E+00 6.6452E+00 -3.2257E+00 -7.6294E-01 -1.1187E+01 -5.2551E+00 -7.0320E+00 -4.0006E+00 -7.1976E-01 3.4970E-01 1.1089E+00 -2.3564E+00 3.6839E+00 -2.0046E+00 -4.5439E+00 -1.4263E+00 0ITERATION NO.: 14 OBJECTIVE VALUE: 33837.6945115337 NO. OF FUNC. EVALS.: 17 CUMULATIVE NO. OF FUNC. EVALS.: 272 NPARAMETR: 1.6695E+00 3.7560E+00 3.7315E+00 1.1641E+00 4.1138E+00 -1.1338E-01 1.0642E+00 8.0728E-01 -4.3042E-01 3.1146E-01 5.9640E-01 2.9444E-01 7.4478E-02 7.2056E-02 6.8907E-01 4.5978E-02 1.5164E+00 PARAMETER: 9.8518E-02 1.1416E-01 1.0356E-01 8.6624E-02 8.0874E-02 9.8604E-02 1.1205E-01 1.0270E-01 1.1843E-01 9.2831E-02 1.0581E-01 1.0608E-01 9.7177E-02 9.9696E-02 1.1254E-01 9.9758E-02 9.8815E-02 GRADIENT: 7.7129E+00 -2.4750E+00 -8.4127E-01 -5.2542E-01 -1.4640E+00 -2.2243E+00 -7.7371E-01 -5.2446E-01 2.5612E+00 -7.3740E-01 -1.9433E-01 1.0952E+00 -2.7359E-01 3.2073E+00 3.8296E+00 2.6685E+00 8.9441E-01 0ITERATION NO.: 15 OBJECTIVE VALUE: 33837.6848585350 NO. OF FUNC. EVALS.: 17 CUMULATIVE NO. OF FUNC. EVALS.: 289 NPARAMETR: 1.6689E+00 3.7552E+00 3.7323E+00 1.1702E+00 4.1155E+00 -1.1342E-01 1.0619E+00 8.0838E-01 -4.3123E-01 3.1393E-01 5.9722E-01 2.9544E-01 7.4496E-02 7.1958E-02 6.8807E-01 4.5973E-02 1.5197E+00 PARAMETER: 9.6992E-02 1.1237E-01 1.0531E-01 1.0034E-01 8.6250E-02 9.8457E-02 1.0552E-01 1.0503E-01 1.1572E-01 1.0433E-01 1.0923E-01 1.1032E-01 9.7293E-02 9.9014E-02 1.1182E-01 9.9704E-02 9.9886E-02 GRADIENT: 5.8211E+00 -2.3247E+00 -6.7880E-01 6.3388E-01 -2.0517E-01 -1.1382E+00 -5.0754E-01 -3.9541E-01 1.9043E+00 1.1864E+00 2.5045E-01 1.4604E+00 5.3048E-01 2.6541E+00 4.8018E+00 3.2431E+00 1.5286E+00 0ITERATION NO.: 16 OBJECTIVE VALUE: 33837.6827255901 NO. OF FUNC. EVALS.: 18 CUMULATIVE NO. OF FUNC. EVALS.: 307 NPARAMETR: 1.6688E+00 3.7547E+00 3.7329E+00 1.1720E+00 4.1156E+00 -1.1313E-01 1.0612E+00 8.0832E-01 -4.3130E-01 3.1323E-01 5.9697E-01 2.9547E-01 7.4493E-02 7.1932E-02 6.8753E-01 4.5974E-02 1.5201E+00 PARAMETER: 9.6651E-02 1.1117E-01 1.0680E-01 1.0448E-01 8.6549E-02 9.9537E-02 1.0346E-01 1.0490E-01 1.1550E-01 1.0106E-01 1.0817E-01 1.1045E-01 9.7275E-02 9.8832E-02 1.1142E-01 9.9719E-02 1.0004E-01 GRADIENT: 5.5603E+00 -2.4351E+00 -4.7173E-01 1.0026E+00 -1.1539E-01 -9.4137E-01 -5.2089E-01 -3.7425E-01 1.8705E+00 6.3519E-01 7.1239E-02 1.4324E+00 6.0777E-01 2.5691E+00 4.9493E+00 3.2695E+00 1.5886E+00 0ITERATION NO.: 17 OBJECTIVE VALUE: 33837.6755730681 NO. OF FUNC. EVALS.: 17 CUMULATIVE NO. OF FUNC. EVALS.: 324 NPARAMETR: 1.6687E+00 3.7550E+00 3.7328E+00 1.1707E+00 4.1136E+00 -1.1026E-01 1.0569E+00 8.0481E-01 -4.3166E-01 3.1346E-01 5.9689E-01 2.9419E-01 7.4516E-02 7.1888E-02 6.8715E-01 4.5974E-02 1.5194E+00 PARAMETER: 9.6543E-02 1.1184E-01 1.0651E-01 1.0162E-01 8.0216E-02 1.1011E-01 9.1247E-02 9.7492E-02 1.1430E-01 1.0213E-01 1.0785E-01 1.0504E-01 9.7427E-02 9.8529E-02 1.1115E-01 9.9718E-02 9.9800E-02 GRADIENT: 4.5347E+00 -1.8687E+00 -5.2575E-01 8.9834E-01 -4.7338E-01 -5.2011E-01 -7.4119E-01 -7.2927E-01 1.4547E+00 7.2130E-01 1.6223E-01 4.9843E-01 5.5779E-01 1.9593E+00 4.0525E+00 2.4847E+00 1.3040E+00 0ITERATION NO.: 18 OBJECTIVE VALUE: 33837.6680713220 NO. OF FUNC. EVALS.: 17 CUMULATIVE NO. OF FUNC. EVALS.: 341 NPARAMETR: 1.6681E+00 3.7555E+00 3.7334E+00 1.1678E+00 4.1138E+00 -1.0943E-01 1.0547E+00 8.0469E-01 -4.3168E-01 3.1310E-01 5.9645E-01 2.9583E-01 7.4558E-02 7.1810E-02 6.8643E-01 4.5979E-02 1.5184E+00 PARAMETER: 9.4831E-02 1.1295E-01 1.0795E-01 9.5125E-02 8.0899E-02 1.1316E-01 8.4992E-02 9.7244E-02 1.1423E-01 1.0046E-01 1.0601E-01 1.1198E-01 9.7709E-02 9.7987E-02 1.1062E-01 9.9769E-02 9.9474E-02 GRADIENT: 3.3947E+00 -1.1846E+00 -4.2472E-01 3.7340E-01 -4.8332E-01 -5.6947E-01 -1.0857E+00 -3.4072E-01 1.2766E+00 3.6289E-01 1.2687E-01 1.2278E+00 2.7115E-01 1.4729E+00 2.5656E+00 1.8574E+00 8.5413E-01 0ITERATION NO.: 19 OBJECTIVE VALUE: 33837.6490673988 NO. OF FUNC. EVALS.: 18 CUMULATIVE NO. OF FUNC. EVALS.: 359 NPARAMETR: 1.6676E+00 3.7555E+00 3.7338E+00 1.1667E+00 4.1152E+00 -1.1179E-01 1.0587E+00 8.0596E-01 -4.3245E-01 3.1289E-01 5.9493E-01 2.9473E-01 7.4588E-02 7.1705E-02 6.8495E-01 4.5986E-02 1.5169E+00 PARAMETER: 9.3550E-02 1.1284E-01 1.0898E-01 9.2677E-02 8.5113E-02 1.0447E-01 9.6295E-02 9.9924E-02 1.1169E-01 9.9498E-02 9.9712E-02 1.0732E-01 9.7912E-02 9.7256E-02 1.0954E-01 9.9848E-02 9.8976E-02 GRADIENT: 7.7492E-01 -3.8001E-01 -2.7374E-01 1.6744E-01 -1.3582E-01 6.1274E-02 -2.0558E-01 -5.1585E-03 4.5957E-01 1.7546E-01 -1.7359E-01 3.7482E-01 6.9740E-02 4.7059E-01 7.7914E-01 7.5789E-01 2.9014E-01 0ITERATION NO.: 20 OBJECTIVE VALUE: 33837.6471908370 NO. OF FUNC. EVALS.: 18 CUMULATIVE NO. OF FUNC. EVALS.: 377 NPARAMETR: 1.6675E+00 3.7555E+00 3.7340E+00 1.1669E+00 4.1153E+00 -1.1218E-01 1.0598E+00 8.0600E-01 -4.3253E-01 3.1216E-01 5.9746E-01 2.9469E-01 7.4603E-02 7.1671E-02 6.8486E-01 4.5985E-02 1.5169E+00 PARAMETER: 9.3347E-02 1.1286E-01 1.0935E-01 9.3061E-02 8.5440E-02 1.0303E-01 9.9513E-02 9.9994E-02 1.1144E-01 9.6111E-02 1.1020E-01 1.0713E-01 9.8014E-02 9.7018E-02 1.0948E-01 9.9834E-02 9.8973E-02 GRADIENT: 4.3984E-01 -2.4332E-01 -2.3894E-01 1.2723E-01 -1.7220E-01 8.8357E-02 -1.2605E-01 4.1526E-02 3.3375E-01 5.2830E-02 1.0868E-01 2.9844E-01 -5.3000E-03 3.4577E-01 4.1210E-01 5.9342E-01 1.6943E-01 0ITERATION NO.: 21 OBJECTIVE VALUE: 33837.6459557616 NO. OF FUNC. EVALS.: 17 CUMULATIVE NO. OF FUNC. EVALS.: 394 NPARAMETR: 1.6675E+00 3.7555E+00 3.7341E+00 1.1666E+00 4.1157E+00 -1.1275E-01 1.0607E+00 8.0641E-01 -4.3271E-01 3.1216E-01 5.9700E-01 2.9439E-01 7.4613E-02 7.1648E-02 6.8453E-01 4.5986E-02 1.5167E+00 PARAMETER: 9.3130E-02 1.1288E-01 1.0971E-01 9.2388E-02 8.6585E-02 1.0093E-01 1.0203E-01 1.0087E-01 1.1084E-01 9.6107E-02 1.0832E-01 1.0590E-01 9.8081E-02 9.6856E-02 1.0923E-01 9.9843E-02 9.8898E-02 GRADIENT: 1.8468E-01 -8.5762E-02 -1.0136E-01 3.5113E-02 -7.2894E-02 -2.5777E-02 -7.9754E-02 -6.8365E-03 1.2579E-01 9.7810E-03 3.9136E-02 1.0136E-01 -5.0932E-03 1.0536E-01 4.5109E-02 2.5260E-01 6.3386E-02 0ITERATION NO.: 22 OBJECTIVE VALUE: 33837.6457948641 NO. OF FUNC. EVALS.: 17 CUMULATIVE NO. OF FUNC. EVALS.: 411 NPARAMETR: 1.6674E+00 3.7555E+00 3.7342E+00 1.1665E+00 4.1159E+00 -1.1308E-01 1.0612E+00 8.0668E-01 -4.3281E-01 3.1217E-01 5.9678E-01 2.9424E-01 7.4617E-02 7.1637E-02 6.8441E-01 4.5986E-02 1.5165E+00 PARAMETER: 9.3025E-02 1.1288E-01 1.0991E-01 9.2093E-02 8.7256E-02 9.9708E-02 1.0353E-01 1.0144E-01 1.1051E-01 9.6120E-02 1.0739E-01 1.0526E-01 9.8110E-02 9.6781E-02 1.0915E-01 9.9843E-02 9.8861E-02 GRADIENT: -1.3304E-02 2.1759E-03 -2.6093E-02 -2.1536E-03 -1.5216E-02 -2.1338E-02 -6.3363E-03 1.0717E-02 8.2180E-03 -1.7233E-03 7.1129E-04 -1.2897E-04 -9.8694E-03 -5.5897E-03 -6.0655E-02 4.1438E-02 3.6837E-03 0ITERATION NO.: 23 OBJECTIVE VALUE: 33837.6457915040 NO. OF FUNC. EVALS.: 17 CUMULATIVE NO. OF FUNC. EVALS.: 428 NPARAMETR: 1.6674E+00 3.7555E+00 3.7342E+00 1.1665E+00 4.1158E+00 -1.1302E-01 1.0611E+00 8.0663E-01 -4.3281E-01 3.1217E-01 5.9678E-01 2.9424E-01 7.4618E-02 7.1637E-02 6.8443E-01 4.5985E-02 1.5166E+00 PARAMETER: 9.3022E-02 1.1288E-01 1.0999E-01 9.2114E-02 8.7153E-02 9.9930E-02 1.0326E-01 1.0132E-01 1.1050E-01 9.6127E-02 1.0738E-01 1.0526E-01 9.8115E-02 9.6780E-02 1.0917E-01 9.9839E-02 9.8866E-02 GRADIENT: 2.2307E-03 9.2358E-03 7.0967E-03 1.2725E-02 6.8830E-03 1.4546E-02 1.3363E-02 -3.7436E-03 -3.4335E-03 8.0530E-05 -8.7422E-04 -9.5193E-04 2.9212E-03 -8.1755E-04 -5.4604E-03 1.2908E-03 3.5778E-04 0ITERATION NO.: 24 OBJECTIVE VALUE: 33837.6457915040 NO. OF FUNC. EVALS.: 37 CUMULATIVE NO. OF FUNC. EVALS.: 465 NPARAMETR: 1.6674E+00 3.7555E+00 3.7342E+00 1.1665E+00 4.1158E+00 -1.1302E-01 1.0611E+00 8.0663E-01 -4.3281E-01 3.1217E-01 5.9678E-01 2.9424E-01 7.4618E-02 7.1637E-02 6.8443E-01 4.5985E-02 1.5166E+00 PARAMETER: 9.3022E-02 1.1288E-01 1.0999E-01 9.2114E-02 8.7153E-02 9.9930E-02 1.0326E-01 1.0132E-01 1.1050E-01 9.6127E-02 1.0738E-01 1.0526E-01 9.8115E-02 9.6780E-02 1.0917E-01 9.9839E-02 9.8866E-02 GRADIENT: -6.8966E-02 -7.5761E-03 -3.2412E-03 5.1060E-03 -1.8230E-02 -1.9757E-02 -9.5766E-03 -2.4682E-02 -8.0140E-03 -2.4859E-03 -1.1785E-03 -3.3871E-03 2.9212E-03 -8.1755E-04 -5.4604E-03 -3.3381E-02 -3.9259E-03 0ITERATION NO.: 25 OBJECTIVE VALUE: 33837.6457898846 NO. OF FUNC. EVALS.: 31 CUMULATIVE NO. OF FUNC. EVALS.: 496 NPARAMETR: 1.6674E+00 3.7555E+00 3.7342E+00 1.1665E+00 4.1159E+00 -1.1303E-01 1.0612E+00 8.0669E-01 -4.3281E-01 3.1217E-01 5.9678E-01 2.9423E-01 7.4618E-02 7.1637E-02 6.8443E-01 4.5985E-02 1.5166E+00 PARAMETER: 9.3059E-02 1.1288E-01 1.0998E-01 9.2115E-02 8.7231E-02 9.9873E-02 1.0331E-01 1.0145E-01 1.1051E-01 9.6126E-02 1.0741E-01 1.0522E-01 9.8114E-02 9.6781E-02 1.0916E-01 9.9841E-02 9.8865E-02 GRADIENT: -4.0364E-02 -3.5912E-03 -2.5345E-03 4.8080E-03 -1.0680E-02 -1.5670E-02 -6.0187E-03 -1.8244E-02 -4.7241E-03 -2.0683E-03 -7.0254E-04 -1.9094E-03 1.1314E-03 -1.5599E-03 -1.0661E-02 -1.7702E-02 -2.2222E-03 0ITERATION NO.: 26 OBJECTIVE VALUE: 33837.6457891011 NO. OF FUNC. EVALS.: 31 CUMULATIVE NO. OF FUNC. EVALS.: 527 NPARAMETR: 1.6674E+00 3.7555E+00 3.7342E+00 1.1665E+00 4.1159E+00 -1.1303E-01 1.0612E+00 8.0670E-01 -4.3281E-01 3.1217E-01 5.9678E-01 2.9423E-01 7.4618E-02 7.1637E-02 6.8443E-01 4.5985E-02 1.5166E+00 PARAMETER: 9.3065E-02 1.1289E-01 1.0998E-01 9.2108E-02 8.7240E-02 9.9879E-02 1.0330E-01 1.0147E-01 1.1052E-01 9.6128E-02 1.0741E-01 1.0521E-01 9.8114E-02 9.6781E-02 1.0917E-01 9.9841E-02 9.8865E-02 GRADIENT: -3.5855E-02 -4.1136E-03 -2.9947E-03 4.4737E-03 -9.2132E-03 -1.3145E-02 -5.2389E-03 -1.6728E-02 -4.0052E-03 -1.8231E-03 -6.7808E-04 -1.6966E-03 1.1028E-03 -7.4646E-04 -8.9348E-03 -1.6229E-02 -2.0750E-03 0ITERATION NO.: 27 OBJECTIVE VALUE: 33837.6457880480 NO. OF FUNC. EVALS.: 31 CUMULATIVE NO. OF FUNC. EVALS.: 558 NPARAMETR: 1.6674E+00 3.7555E+00 3.7342E+00 1.1665E+00 4.1159E+00 -1.1303E-01 1.0612E+00 8.0671E-01 -4.3281E-01 3.1217E-01 5.9679E-01 2.9423E-01 7.4618E-02 7.1637E-02 6.8443E-01 4.5985E-02 1.5166E+00 PARAMETER: 9.3072E-02 1.1289E-01 1.0999E-01 9.2101E-02 8.7254E-02 9.9874E-02 1.0330E-01 1.0150E-01 1.1052E-01 9.6129E-02 1.0742E-01 1.0520E-01 9.8115E-02 9.6781E-02 1.0917E-01 9.9841E-02 9.8865E-02 GRADIENT: -3.2388E-02 -6.1964E-03 -5.9449E-03 3.9472E-03 -8.4853E-03 -1.1946E-02 -4.4684E-03 -1.4300E-02 -3.0798E-03 -1.6416E-03 -5.9537E-04 -1.5014E-03 1.1919E-03 -2.8242E-04 -8.6204E-03 -1.3191E-02 -1.9104E-03 0ITERATION NO.: 28 OBJECTIVE VALUE: 33837.6457847597 NO. OF FUNC. EVALS.: 32 CUMULATIVE NO. OF FUNC. EVALS.: 590 NPARAMETR: 1.6674E+00 3.7555E+00 3.7343E+00 1.1665E+00 4.1159E+00 -1.1302E-01 1.0611E+00 8.0677E-01 -4.3280E-01 3.1217E-01 5.9679E-01 2.9422E-01 7.4619E-02 7.1637E-02 6.8444E-01 4.5986E-02 1.5166E+00 PARAMETER: 9.3106E-02 1.1291E-01 1.1004E-01 9.2032E-02 8.7306E-02 9.9917E-02 1.0321E-01 1.0162E-01 1.1054E-01 9.6139E-02 1.0742E-01 1.0517E-01 9.8118E-02 9.6779E-02 1.0917E-01 9.9843E-02 9.8867E-02 GRADIENT: -6.0998E-03 1.5200E-02 1.6879E-02 5.1587E-05 -2.1719E-05 -6.3144E-04 -2.4171E-03 -5.8293E-03 -3.1811E-03 -4.3907E-04 -2.0526E-04 -2.5009E-04 -1.5505E-04 -6.7378E-03 4.0599E-03 -1.0106E-02 -7.2578E-05 0ITERATION NO.: 29 OBJECTIVE VALUE: 33837.6457847597 NO. OF FUNC. EVALS.: 28 CUMULATIVE NO. OF FUNC. EVALS.: 618 NPARAMETR: 1.6674E+00 3.7555E+00 3.7343E+00 1.1665E+00 4.1159E+00 -1.1302E-01 1.0611E+00 8.0677E-01 -4.3280E-01 3.1217E-01 5.9679E-01 2.9422E-01 7.4619E-02 7.1637E-02 6.8444E-01 4.5986E-02 1.5166E+00 PARAMETER: 9.3106E-02 1.1291E-01 1.1004E-01 9.2032E-02 8.7306E-02 9.9917E-02 1.0321E-01 1.0162E-01 1.1054E-01 9.6139E-02 1.0742E-01 1.0517E-01 9.8118E-02 9.6779E-02 1.0917E-01 9.9843E-02 9.8867E-02 GRADIENT: -6.0998E-03 1.5200E-02 1.6879E-02 5.1587E-05 -2.1719E-05 -6.3144E-04 -2.4171E-03 -5.8293E-03 -3.1811E-03 -4.3907E-04 -2.0526E-04 -2.5009E-04 -1.5505E-04 -6.7378E-03 4.0599E-03 -1.0106E-02 -7.2578E-05 #TERM: 0MINIMIZATION SUCCESSFUL NO. OF FUNCTION EVALUATIONS USED: 618 NO. OF SIG. DIGITS IN FINAL EST.: 3.2 ETABAR IS THE ARITHMETIC MEAN OF THE ETA-ESTIMATES, AND THE P-VALUE IS GIVEN FOR THE NULL HYPOTHESIS THAT THE TRUE MEAN IS 0. ETABAR: 2.0613E-03 -1.2315E-02 6.5991E-03 0.0000E+00 SE: 3.7994E-03 3.0414E-03 8.6891E-03 0.0000E+00 N: 2544 2544 2544 2544 P VAL.: 5.8744E-01 5.1438E-05 4.4757E-01 1.0000E+00 ETAshrink(%): 2.9832E+01 4.2674E+01 4.7015E+01 1.0000E+02 EBVshrink(%): 2.9184E+01 4.2161E+01 4.8237E+01 0.0000E+00 EPSshrink(%): 1.7539E+01 1.7539E+01 #TERE: Elapsed estimation time in seconds: 828.79 1 ************************************************************************************************************************ ******************** ******************** ******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ******************** #OBJT:************** MINIMUM VALUE OF OBJECTIVE FUNCTION ******************** ******************** ******************** ************************************************************************************************************************ #OBJV:******************************************** 33837.646 ************************************************** 1 ************************************************************************************************************************ ******************** ******************** ******************** FIRST ORDER CONDITIONAL ESTIMATION WITH INTERACTION ******************** ******************** FINAL PARAMETER ESTIMATE ******************** ******************** ******************** ************************************************************************************************************************ THETA - VECTOR OF FIXED EFFECTS PARAMETERS ********* TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10 TH11 TH12 1.67E+00 3.76E+00 3.73E+00 1.17E+00 4.12E+00 -1.13E-01 1.06E+00 8.07E-01 -4.33E-01 3.12E-01 5.97E-01 2.94E-01 OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ******** ETA1 ETA2 ETA3 ETA4 ETA1 + 7.46E-02 ETA2 + 0.00E+00 7.16E-02 ETA3 + 0.00E+00 0.00E+00 6.84E-01 ETA4 + 0.00E+00 0.00E+00 0.00E+00 0.00E+00 SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS **** EPS1 EPS2 EPS1 + 4.60E-02 EPS2 + 0.00E+00 1.52E+00 1 OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS ******* ETA1 ETA2 ETA3 ETA4 ETA1 + 2.73E-01 ETA2 + 0.00E+00 2.68E-01 ETA3 + 0.00E+00 0.00E+00 8.27E-01 ETA4 + 0.00E+00 0.00E+00 0.00E+00 0.00E+00 SIGMA - CORR MATRIX FOR RANDOM EFFECTS - EPSILONS *** EPS1 EPS2 EPS1 + 2.14E-01 EPS2 + 0.00E+00 1.23E+00 #CPUT: Total CPU Time in Seconds, 1744.952 Stop Time: do 20/09/2018 10:01