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{"sheet":"Table S5","index":0,"n_rows":678,"n_cols":25,"rows_kept":678,"merged":[[3,0,4,0],[3,1,3,12],[3,13,3,24],[4,1,4,6],[4,7,4,12],[4,13,4,18],[4,19,4,24],[5,0,6,0]],"flags":["formulas_cached_only"]}
["Supplementary Table 5. List of 671 genes with excess per-sample nonsynonymous variants burden. \n"]
["Colored cells correspond to genes that exceed the cut-off criteria of each group. KOR: Korean. 1KG: 1,000 Genomes Project. EAS: East Asian. SAS: South Asian. EUR: European. AFR: African. AMR: American."]
[]
["Classification","By the count",{"$nulls":11},"By the rate (*10-3)"]
[null,"Using entire nonsynonymous variants",{"$nulls":5},"Using rare nonsynonymous variants",{"$nulls":5},"Using entire nonsynonymous variants",{"$nulls":5},"Using rare nonsynonymous variants"]
["Population/\nCutoff values","KOR","1KG-EAS ","1KG-EUR ","1KG-SAS ","1KG-AFR ","1KG-AMR ","KOR","1KG-EAS ","1KG-EUR ","1KG-SAS ","1KG-AFR ","1KG-AMR ","KOR","1KG-EAS ","1KG-EUR ","1KG-SAS ","1KG-AFR ","1KG-AMR ","KOR","1KG-EAS ","1KG-EUR ","1KG-SAS ","1KG-AFR ","1KG-AMR "]
[null,1.881,2.437,2.418,2.425,2.645,2.449,0.064,0.07,0.075,0.115,0.229,0.082,0.778,1.045,1.043,1.067,1.191,1.062,0.027,0.029,0.032,0.047,0.103,0.036]
["MUC16",{"v":46.72442747505756,"d":"46.724"},48.774,49.859,48.963,48.02,50.637,{"v":0.6065134305448964,"d":"0.607"},0.645,0.847,1.283,3.266,0.804,{"v":1.0735324757618225,"d":"1.074"},{"v":1.1206231044940722,"d":"1.121"},{"v":1.1455518794228472,"d":"1.146"},{"v":1.1249655362558588,"d":"1.125"},{"v":1.1032993291057807,"d":"1.103"},{"v":1.1634270747173974,"d":"1.163"},{"v":0.013935149125652432,"d":"0.014"},{"v":0.014819409980700303,"d":"0.015"},{"v":0.019460527525043653,"d":"0.019"},{"v":0.02947798915540851,"d":"0.029"},{"v":0.07503905891002666,"d":"0.075"},{"v":0.018472566859663635,"d":"0.018"}]
["TTN",{"v":28.12821642363776,"d":"28.128"},33.407,23.392,30.041,33.038,28.04,{"v":1.3173768227168072,"d":"1.317"},1.341,1.352,3.285,3.566,1.553,{"v":0.26050433821995406,"d":"0.261"},{"v":0.3093928280358598,"d":"0.309"},{"v":0.2166407349781433,"d":"0.217"},{"v":0.27821923390383047,"d":"0.278"},{"v":0.3059754019411721,"d":"0.306"},{"v":0.2596873379269467,"d":"0.260"},{"v":0.012200644798073715,"d":"0.012"},{"v":0.01241942653923094,"d":"0.012"},{"v":0.012521301029858488,"d":"0.013"},{"v":0.030423427428317405,"d":"0.030"},{"v":0.03302585759798474,"d":"0.033"},{"v":0.014382825813143662,"d":"0.014"}]
["CMYA5",{"v":17.991516500383728,"d":"17.992"},14.466,5.362,6.529,16.104,5.66,{"v":0.1051396776669225,"d":"0.105"},0.113,0.159,0.289,0.643,0.199,{"v":1.4735066748881023,"d":"1.474"},{"v":1.1847665847665847,"d":"1.185"},{"v":0.43914823914823914,"d":"0.439"},{"v":0.5347256347256347,"d":"0.535"},{"v":1.318918918918919,"d":"1.319"},{"v":0.46355446355446356,"d":"0.464"},{"v":0.008610948211869163,"d":"0.009"},{"v":0.009254709254709255,"d":"0.009"},{"v":0.013022113022113022,"d":"0.013"},{"v":0.02366912366912367,"d":"0.024"},{"v":0.05266175266175266,"d":"0.053"},{"v":0.016298116298116297,"d":"0.016"}]
["OBSCN",{"v":16.78642594013814,"d":"16.786"},22.724,17.809,15.703,21.448,18.963,{"v":0.35291634689178814,"d":"0.353"},0.49,0.469,0.871,1.955,0.735,{"v":0.6270142664028889,"d":"0.627"},{"v":0.8487972508591065,"d":"0.849"},{"v":0.6652099208127895,"d":"0.665"},{"v":0.5865456447034215,"d":"0.587"},{"v":0.8011355147168684,"d":"0.801"},{"v":0.7083146571044374,"d":"0.708"},{"v":0.013182292951284485,"d":"0.013"},{"v":0.018302704317944122,"d":"0.018"},{"v":0.017518302704317944,"d":"0.018"},{"v":0.03253399073659047,"d":"0.033"},{"v":0.07302405498281787,"d":"0.073"},{"v":0.02745405647691618,"d":"0.027"}]
["FSIP2",{"v":14.642181887950882,"d":"14.642"},15.806,16.61,18.744,18.457,16.798,{"v":0.1985287797390637,"d":"0.199"},0.214,0.189,0.279,0.655,0.251,{"v":0.6975457047282588,"d":"0.698"},{"v":0.7529893763994092,"d":"0.753"},{"v":0.7912915058834739,"d":"0.791"},{"v":0.8929541231956553,"d":"0.893"},{"v":0.8792815968748511,"d":"0.879"},{"v":0.8002477252155685,"d":"0.800"},{"v":0.009457804761043482,"d":"0.009"},{"v":0.010194845409937592,"d":"0.010"},{"v":0.009003858796627125,"d":"0.009"},{"v":0.013291410604544805,"d":"0.013"},{"v":0.03120384926873422,"d":"0.031"},{"v":0.011957505597637082,"d":"0.012"}]
["DNAH14",{"v":12.214255564082883,"d":"12.214"},12.353,12.318,12.303,11.764,12.651,{"v":0.19790406753645437,"d":"0.198"},0.169,0.201,0.248,0.743,0.3,{"v":0.9015541455626577,"d":"0.902"},{"v":0.9117950989075878,"d":"0.912"},{"v":0.9092116917626218,"d":"0.909"},{"v":0.9081045172719221,"d":"0.908"},{"v":0.8683200472394449,"d":"0.868"},{"v":0.9337909654561559,"d":"0.934"},{"v":0.014607622345471976,"d":"0.015"},{"v":0.01247416592855034,"d":"0.012"},{"v":0.01483613817537644,"d":"0.015"},{"v":0.018305284912902273,"d":"0.018"},{"v":0.054842043105993506,"d":"0.055"},{"v":0.022143489813994686,"d":"0.022"}]
["MKI67",{"v":11.399159631619339,"d":"11.399"},10.272,10.312,8.949,11.461,12.239,{"v":0.17091481197237146,"d":"0.171"},0.153,0.249,0.281,0.33,0.222,{"v":1.166631832117423,"d":"1.167"},{"v":1.0512741786920479,"d":"1.051"},{"v":1.0553679254938082,"d":"1.055"},{"v":0.9158735032238257,"d":"0.916"},{"v":1.1729608023743732,"d":"1.173"},{"v":1.2525841776686113,"d":"1.253"},{"v":0.017492049122134014,"d":"0.017"},{"v":0.01565858151673319,"d":"0.016"},{"v":0.025483573840957938,"d":"0.025"},{"v":0.028758571282366186,"d":"0.029"},{"v":0.03377341111452257,"d":"0.034"},{"v":0.022720294749769727,"d":"0.023"}]
["MUC4",{"v":11.24518726016884,"d":"11.245"},19.52,20.686,19.26,22.843,18.084,{"v":0.08639447429009978,"d":"0.086"},0.21,0.274,0.596,1.106,0.262,{"v":0.6924802795842626,"d":"0.692"},{"v":1.202044460865817,"d":"1.202"},{"v":1.27384691175565,"d":"1.274"},{"v":1.186033622760022,"d":"1.186"},{"v":1.406675287887185,"d":"1.407"},{"v":1.1136153704045815,"d":"1.114"},{"v":0.005320184388823188,"d":"0.005"},{"v":0.012931830777757251,"d":"0.013"},{"v":0.016872960157645174,"d":"0.017"},{"v":0.03670176735020629,"d":"0.037"},{"v":0.06810764209618819,"d":"0.068"},{"v":0.01613399839891619,"d":"0.016"}]
["SYNE2",{"v":10.117853415195704,"d":"10.118"},10.474,10.107,10.09,10.436,10.833,{"v":0.2748672294704528,"d":"0.275"},0.232,0.276,0.436,0.982,0.357,{"v":0.48821913796543637,"d":"0.488"},{"v":0.5054043620922601,"d":"0.505"},{"v":0.48769542559351475,"d":"0.488"},{"v":0.4868751206330824,"d":"0.487"},{"v":0.503570739239529,"d":"0.504"},{"v":0.5227272727272727,"d":"0.523"},{"v":0.01326323245852407,"d":"0.013"},{"v":0.011194750048253233,"d":"0.011"},{"v":0.013317892298784018,"d":"0.013"},{"v":0.02103840957344142,"d":"0.021"},{"v":0.0473846747732098,"d":"0.047"},{"v":0.017226404169079328,"d":"0.017"}]
["ADGRV1",{"v":9.606902532617038,"d":"9.607"},11.165,10.101,10.459,12.141,11.317,{"v":0.21211665387567155,"d":"0.212"},0.165,0.382,0.35,0.846,0.36,{"v":0.5077375684486569,"d":"0.508"},{"v":0.5900850906400296,"d":"0.590"},{"v":0.5338512763596004,"d":"0.534"},{"v":0.5527720522171132,"d":"0.553"},{"v":0.641667987949897,"d":"0.642"},{"v":0.5981184926800909,"d":"0.598"},{"v":0.011210647105103933,"d":"0.011"},{"v":0.008720469319803394,"d":"0.009"},{"v":0.020189207758575127,"d":"0.020"},{"v":0.01849796522382538,"d":"0.018"},{"v":0.04471222451244649,"d":"0.045"},{"v":0.019026478515934676,"d":"0.019"}]
["NEB",{"v":9.282254796623178,"d":"9.282"},10.976,9.064,8.924,8.859,9.081,{"v":0.40012893323100535,"d":"0.400"},0.343,0.322,0.496,0.825,0.334,{"v":0.36141629858751617,"d":"0.361"},{"v":0.4273644044698828,"d":"0.427"},{"v":0.352918272787447,"d":"0.353"},{"v":0.3474671961998209,"d":"0.347"},{"v":0.3449363392127088,"d":"0.345"},{"v":0.3535801892302301,"d":"0.354"},{"v":0.015579524714052306,"d":"0.016"},{"v":0.013355137639683837,"d":"0.013"},{"v":0.012537476151539929,"d":"0.013"},{"v":0.019312385624732312,"d":"0.019"},{"v":0.03212241560565354,"d":"0.032"},{"v":0.013004711287622163,"d":"0.013"}]
["VWDE",{"v":9.21620107444359,"d":"9.216"},8.984,7.917,8.93,12.262,8.029,{"v":0.058672294704528005,"d":"0.059"},0.073,0.066,0.121,0.386,0.086,{"v":1.9309032211279262,"d":"1.931"},{"v":1.8822543473706264,"d":"1.882"},{"v":1.6587052168447518,"d":"1.659"},{"v":1.8709407081500105,"d":"1.871"},{"v":2.5690341504294993,"d":"2.569"},{"v":1.682170542635659,"d":"1.682"},{"v":0.012292540269123825,"d":"0.012"},{"v":0.015294364131573434,"d":"0.015"},{"v":0.013827781269641735,"d":"0.014"},{"v":0.025350932327676514,"d":"0.025"},{"v":0.08087156924366226,"d":"0.081"},{"v":0.018018018018018018,"d":"0.018"}]
["PARP4",{"v":8.98608979278588,"d":"8.986"},11.169,11.612,10.605,13.124,11.242,{"v":0.03206600153491942,"d":"0.032"},0.081,0.08,0.102,0.263,0.046,{"v":1.7364424720359184,"d":"1.736"},{"v":2.1582608695652175,"d":"2.158"},{"v":2.243864734299517,"d":"2.244"},{"v":2.0492753623188404,"d":"2.049"},{"v":2.5360386473429952,"d":"2.536"},{"v":2.172367149758454,"d":"2.172"},{"v":0.006196328799018245,"d":"0.006"},{"v":0.01565217391304348,"d":"0.016"},{"v":0.015458937198067632,"d":"0.015"},{"v":0.01971014492753623,"d":"0.020"},{"v":0.050821256038647344,"d":"0.051"},{"v":0.008888888888888889,"d":"0.009"}]
["CCDC168",{"v":8.871833461243286,"d":"8.872"},15.833,17.551,18.129,18.34,16.859,{"v":0.18070683039140445,"d":"0.181"},0.216,0.388,0.406,1.156,0.383,{"v":0.4175766478981119,"d":"0.418"},{"v":0.7452226301421444,"d":"0.745"},{"v":0.8260849101007248,"d":"0.826"},{"v":0.853290031064671,"d":"0.853"},{"v":0.8632213122470112,"d":"0.863"},{"v":0.7935140732373153,"d":"0.794"},{"v":0.008505451868182457,"d":"0.009"},{"v":0.010166619598983339,"d":"0.010"},{"v":0.018262261131507106,"d":"0.018"},{"v":0.019109479431422386,"d":"0.019"},{"v":0.05441024192789231,"d":"0.054"},{"v":0.018026922714863974,"d":"0.018"}]
["PRUNE2",{"v":8.553727551803531,"d":"8.554"},9.724,9.082,8.516,9.222,9.403,{"v":0.09896546431312356,"d":"0.099"},0.103,0.145,0.172,0.536,0.164,{"v":0.9230309217442031,"d":"0.923"},{"v":1.0493147728498975,"d":"1.049"},{"v":0.980036689327722,"d":"0.980"},{"v":0.9189597496492932,"d":"0.919"},{"v":0.9951440595662027,"d":"0.995"},{"v":1.0146757310888097,"d":"1.015"},{"v":0.010679342215724998,"d":"0.011"},{"v":0.011114708104025034,"d":"0.011"},{"v":0.015646919175569225,"d":"0.016"},{"v":0.01856048343584763,"d":"0.019"},{"v":0.05783964605589727,"d":"0.058"},{"v":0.01769720513650588,"d":"0.018"}]
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["FAT1",{"v":7.884434382194936,"d":"7.884"},9.169,8.431,7.693,9.05,9.418,{"v":0.21540675364543363,"d":"0.215"},0.226,0.266,0.256,0.666,0.213,{"v":0.5727053375604659,"d":"0.573"},{"v":0.6660129294690201,"d":"0.666"},{"v":0.6124064792620033,"d":"0.612"},{"v":0.5588000290549866,"d":"0.559"},{"v":0.6573690709668046,"d":"0.657"},{"v":0.6840996586039079,"d":"0.684"},{"v":0.015646600831367298,"d":"0.016"},{"v":0.016416067407568825,"d":"0.016"},{"v":0.019321566063775695,"d":"0.019"},{"v":0.018595191399723977,"d":"0.019"},{"v":0.04837655262584441,"d":"0.048"},{"v":0.01547178034430159,"d":"0.015"}]
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