Nomenclature and notation: The term "universe" in this context refers to the set of genes relative to which attribute overrepresentation has been measured. In the column headings below we have used the following notation. The letters "I" and "C" are short hand for "gene is in complex" and "gene has characteristic", respectively. The "characteristic" refers to the GO attribute corresponding to each row. The symbol "&" denotes the boolean AND operation, and the symbol "!" denotes boolean NOT. Hence, the expression "I&!C" is shorthand for "the set of genes that belong to the complex but do not have characteristic listed on this row." In particular, the first column, "I&C", gives the number of genes in the complex that have a given GO attribute. The letter "P" denotes "estimated probability". Therefore expression "P(C)" refers to the estimated probability, for genes in the current universe, that a gene will have the attribute for a given row, and the expression "P(C|I)" gives the estimated probability that a gene will have this attribute given that it belongs to the complex. "lod", "p_raw", and "p_adj" refer to log odds ratio, raw P-value, and adjusted P-value, as described in the text of the paper. The "name" column gives the name of the GO attribute. Only those rows corresponding to attributes with a p_adj <= 0.1 have been shown. (Therefore, for many complexes no attribute statistics are shown.) Interactions within complexes are shown as pairs of Entrez gene ids, one interaction per line. =============================================================================== Complex CCSB-HI1.04 Size of complex: 5 Size of universe: 1549 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 2 6 1538 0.6 0.33 0.0058 0.0039 2.5 1.4e-06 < 0.001 small protein conjugating enzyme activity 4 1 41 1503 0.8 0.089 0.029 0.027 2 3.1e-06 < 0.001 acid-amino acid ligase activity/peptide synthase 5 0 125 1419 1 0.038 0.084 0.081 2.1 3.9e-06 < 0.001 protein modification 4 1 47 1497 0.8 0.078 0.033 0.03 2 5.1e-06 < 0.001 ligase activity, forming carbon-nitrogen bonds 4 1 50 1494 0.8 0.074 0.035 0.032 1.9 6.4e-06 < 0.001 ligase activity 5 0 252 1292 1 0.019 0.17 0.16 1.8 0.00012 0.008 cellular protein metabolism 5 0 256 1288 1 0.019 0.17 0.17 1.7 0.00013 0.013 protein metabolism/protein metabolism and modification 5 0 274 1270 1 0.018 0.18 0.18 1.7 0.00018 0.015 cellular macromolecule metabolism 5 0 288 1256 1 0.017 0.19 0.19 1.7 0.00024 0.018 macromolecule metabolism 5 0 380 1164 1 0.013 0.25 0.25 1.5 0.00093 0.053 catalytic activity/enzyme activity Interactions within complex: 7321 55658 7321 56658 7323 55658 7323 56658 51619 55658 51619 56658 56658 56658 =============================================================================== Complex CCSB-HI1.14 Size of complex: 9 Size of universe: 1549 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 7 0 1540 0.22 1 0.0013 0 3 3e-05 0.006 diphosphotransferase activity 2 7 3 1537 0.22 0.4 0.0032 0.0019 2.2 0.0003 0.046 carbohydrate kinase activity Interactions within complex: 5092 5092 5092 26003 5631 5631 5631 5635 5631 26003 5631 51324 5635 5635 6303 6303 6303 81628 10567 10567 10567 51324 26003 81628 51076 51076 51076 51324 =============================================================================== Complex CCSB-HI1.12 Size of complex: 6 Size of universe: 1549 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 4 2 1541 0.33 0.5 0.0026 0.0013 2.5 7.5e-05 0.009 tubulin binding Interactions within complex: 4005 10982 4005 22924 6271 6271 6271 60491 8996 8996 8996 60491 10982 10982 10982 22924 10982 60491 60491 60491 =============================================================================== Complex CCSB-HI1.10 Size of complex: 5 Size of universe: 1549 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 3 4 1540 0.4 0.33 0.0039 0.0026 2.4 0.00012 0.013 synaptic transmission 2 3 11 1533 0.4 0.15 0.0084 0.0071 2 0.00064 0.036 transmission of nerve impulse 2 3 11 1533 0.4 0.15 0.0084 0.0071 2 0.00064 0.036 cell-cell signaling/cell-cell signalling Interactions within complex: 2752 2752 2752 79666 10403 26258 10403 51019 26258 26258 26258 51019 26258 79666 =============================================================================== Complex CCSB-HI1.03 Size of complex: 9 Size of universe: 1549 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 7 1 1539 0.22 0.67 0.0019 0.00065 2.5 9e-05 0.016 plasma membrane organization and biogenesis 2 7 2 1538 0.22 0.5 0.0026 0.0013 2.3 0.00018 0.024 phospholipid transporter activity 2 7 2 1538 0.22 0.5 0.0026 0.0013 2.3 0.00018 0.024 coagulation/clotting 2 7 2 1538 0.22 0.5 0.0026 0.0013 2.3 0.00018 0.024 lipid transporter activity/lipophorin 2 7 2 1538 0.22 0.5 0.0026 0.0013 2.3 0.00018 0.024 hemostasis 2 7 2 1538 0.22 0.5 0.0026 0.0013 2.3 0.00018 0.024 membrane organization and biogenesis 2 7 2 1538 0.22 0.5 0.0026 0.0013 2.3 0.00018 0.024 wound healing 2 7 4 1536 0.22 0.33 0.0039 0.0026 2.1 0.00044 0.039 regulation of body fluids Interactions within complex: 1911 1912 1911 51460 1912 1912 1912 2275 1912 51460 2275 3927 3927 5359 3927 9319 5359 54973 5359 57088 9319 9319 9319 54973 9319 57088 =============================================================================== Complex CCSB-HI1.07 Size of complex: 3 Size of universe: 1549 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 1 13 1533 0.67 0.13 0.0097 0.0084 2.3 0.00026 0.019 positive regulation of programmed cell death 2 1 14 1532 0.67 0.12 0.01 0.0091 2.2 0.0003 0.019 mitochondrion 2 1 15 1531 0.67 0.12 0.011 0.0097 2.2 0.00034 0.024 negative regulation of apoptosis 2 1 17 1529 0.67 0.11 0.012 0.011 2.2 0.00042 0.026 negative regulation of programmed cell death 3 0 117 1429 1 0.025 0.077 0.076 1.9 0.00045 0.027 intrinsic to membrane 2 1 29 1517 0.67 0.065 0.02 0.019 1.9 0.0011 0.048 regulation of apoptosis 2 1 32 1514 0.67 0.059 0.022 0.021 1.9 0.0014 0.051 positive regulation of cellular physiological process 2 1 32 1514 0.67 0.059 0.022 0.021 1.9 0.0014 0.051 positive regulation of physiological process 3 0 175 1371 1 0.017 0.11 0.11 1.7 0.0015 0.055 membrane 2 1 35 1511 0.67 0.054 0.024 0.023 1.9 0.0016 0.06 regulation of programmed cell death 2 1 37 1509 0.67 0.051 0.025 0.024 1.8 0.0018 0.062 organelle membrane 2 1 37 1509 0.67 0.051 0.025 0.024 1.8 0.0018 0.062 apoptosis/type I programmed cell death Interactions within complex: 664 664 664 665 664 8834 665 665 665 8834 =============================================================================== Complex CCSB-HI1.05 Size of complex: 30 Interactions within complex: 373 373 373 7536 373 9883 373 51545 373 58500 373 79173 373 80308 1857 11143 1857 59349 4591 51224 4591 147687 4841 4841 4841 8379 7536 11030 7718 11143 7718 51224 7718 58500 8379 8379 8379 56159 8440 56243 8440 79869 9883 10087 9883 11030 9883 56159 10016 10016 10016 93487 10087 10087 10534 10534 10534 151254 11030 11030 11030 51545 11030 84970 11051 11051 11051 79869 23099 51224 23099 147687 54550 54550 54550 56159 56159 56243 56159 151254 59349 59349 79173 79173 80308 80308 84970 93487 93487 93487 =============================================================================== Complex CCSB-HI1.06 Size of complex: 12 Interactions within complex: 875 875 875 9513 2203 2203 2203 9513 9513 9513 9513 10197 9513 10241 9513 10313 9513 10606 9513 22978 9513 51421 9513 57142 9513 151871 9513 283518 10197 10197 10241 10241 10313 10313 10313 57142 10606 10606 22978 22978 51421 51421 151871 151871 283518 283518 =============================================================================== Complex CCSB-HI1.17 Size of complex: 3 Interactions within complex: 407 1856 407 27232 1856 1856 27232 27232 =============================================================================== Complex CCSB-HI1.16 Size of complex: 3 Interactions within complex: 27229 79734 27229 83878 79734 79734 83878 83878 =============================================================================== Complex CCSB-HI1.21 Size of complex: 3 Interactions within complex: 5152 5152 5152 22954 22954 29979 29979 29979 =============================================================================== Complex CCSB-HI1.02 Size of complex: 4 Interactions within complex: 87 4110 87 58529 4110 11284 4110 58529 11284 58529 =============================================================================== Complex CCSB-HI1.11 Size of complex: 3 Interactions within complex: 23265 79036 23265 90410 79036 90410 =============================================================================== Complex CCSB-HI1.18 Size of complex: 3 Interactions within complex: 6606 6606 6606 55093 55093 79077 79077 79077 =============================================================================== Complex CCSB-HI1.01 Size of complex: 7 Interactions within complex: 3190 3190 3190 10179 3190 10656 3190 27316 3190 202559 10179 10656 10179 27316 10656 27316 10656 202559 27316 83640 27316 202559 83640 84528 84528 84528 =============================================================================== Complex CCSB-HI1.15 Size of complex: 8 Interactions within complex: 1602 7329 1602 55577 2130 4089 2130 55297 4089 7329 6990 6990 6990 54997 54997 55297 55577 55577 =============================================================================== Complex CCSB-HI1.20 Size of complex: 3 Interactions within complex: 5050 5050 5050 84708 51074 51074 51074 84708 =============================================================================== Complex CCSB-HI1.08 Size of complex: 10 Interactions within complex: 7138 7138 7138 8500 7138 22981 8500 51562 10813 22981 10813 23641 22981 51562 22981 84445 23641 54906 23641 64376 23650 23650 23650 84445 51562 51562 54906 54906 64376 64376 =============================================================================== Complex CCSB-HI1.09 Size of complex: 4 Interactions within complex: 862 51225 862 220766 51225 220766 138046 138046 138046 220766 220766 220766 =============================================================================== Complex CCSB-HI1.19 Size of complex: 3 Interactions within complex: 5866 5866 5866 79873 51171 51171 51171 79873 =============================================================================== Complex CCSB-HI1.13 Size of complex: 4 Interactions within complex: 5932 5933 5932 283987 5933 57596 57596 283987 =============================================================================== Complex CCSB-HI1-union-LCI.11 Size of complex: 37 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 16 21 150 2947 0.43 0.096 0.053 0.048 1.2 9.2e-12 < 0.001 cell surface receptor linked signal transduction 22 15 395 2702 0.59 0.053 0.13 0.13 1 4.4e-11 < 0.001 signal transduction 9 28 40 3057 0.24 0.18 0.016 0.013 1.4 2.3e-09 < 0.001 G-protein coupled receptor protein signaling pathway/G-protein coupled receptor protein signalling pathway 10 27 115 2982 0.27 0.08 0.04 0.037 0.99 9.9e-07 < 0.001 macromolecule biosynthesis 22 15 681 2416 0.59 0.031 0.22 0.22 0.71 1.1e-06 < 0.001 cell communication 12 25 186 2911 0.32 0.061 0.063 0.06 0.88 1.3e-06 < 0.001 intracellular signaling cascade/intracellular signalling cascade 9 28 94 3003 0.24 0.087 0.033 0.03 1 1.8e-06 < 0.001 guanyl nucleotide binding 6 31 30 3067 0.16 0.17 0.011 0.0097 1.3 2.7e-06 < 0.001 translation factor activity, nucleic acid binding 7 30 49 3048 0.19 0.12 0.018 0.016 1.2 2.7e-06 < 0.001 translation/protein translation 6 31 32 3065 0.16 0.16 0.012 0.01 1.3 3.7e-06 < 0.001 translation regulator activity 4 33 10 3087 0.11 0.29 0.0045 0.0032 1.6 1.5e-05 0.006 extrinsic to plasma membrane/juxtamembrane/peripheral plasma membrane protein 7 30 71 3026 0.19 0.09 0.025 0.023 1 2.5e-05 0.007 protein biosynthesis 4 33 12 3085 0.11 0.25 0.0051 0.0039 1.5 2.7e-05 0.007 extrinsic to membrane/peripheral membrane protein 6 31 47 3050 0.16 0.11 0.017 0.015 1.1 2.7e-05 0.007 regulation of signal transduction 6 31 48 3049 0.16 0.11 0.017 0.015 1.1 3e-05 0.009 GTPase regulator activity 5 32 28 3069 0.14 0.15 0.011 0.009 1.3 3.2e-05 0.009 rhodopsin-like receptor activity/Class A G-protein coupled receptor 10 27 175 2922 0.27 0.054 0.059 0.057 0.8 3.5e-05 0.01 cellular biosynthesis 5 32 30 3067 0.14 0.14 0.011 0.0097 1.2 4.4e-05 0.01 second-messenger-mediated signaling/second-messenger-mediated signalling 10 27 192 2905 0.27 0.05 0.064 0.062 0.76 7.4e-05 0.013 biosynthesis/anabolism 5 32 34 3063 0.14 0.13 0.012 0.011 1.2 7.5e-05 0.013 G-protein coupled receptor activity/G-protein linked receptor/GPCR 7 30 94 3003 0.19 0.069 0.032 0.03 0.89 0.00014 0.053 nucleoside-triphosphatase activity/nucleoside triphosphatase activity 7 30 112 2985 0.19 0.059 0.038 0.036 0.81 0.00038 0.081 pyrophosphatase activity 7 30 112 2985 0.19 0.059 0.038 0.036 0.81 0.00038 0.081 hydrolase activity, acting on acid anhydrides 7 30 112 2985 0.19 0.059 0.038 0.036 0.81 0.00038 0.081 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Interactions within complex: 134 2775 134 2781 1816 2768 1816 2781 1816 10672 1915 7407 1915 22803 1933 1937 1933 3035 1936 1936 1936 1937 1936 7407 1937 3035 1984 6125 1984 22803 2149 2768 2149 2769 2149 6642 2149 10672 2768 2782 2768 7253 2768 8698 2769 5997 2769 7265 2775 5999 2775 6000 2775 10636 2778 2782 2778 5997 2778 7265 2781 6000 3035 6125 3434 3437 3434 3646 3437 3437 3646 10900 3646 51386 5147 5906 5147 5912 5906 10636 5912 10900 5997 9276 5999 9276 6642 6642 7253 10672 8698 10672 9138 9138 9138 10672 22803 51386 =============================================================================== Complex CCSB-HI1-union-LCI.18 Size of complex: 18 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 4 14 1 3115 0.22 0.8 0.0016 0.00032 2.8 3.8e-09 < 0.001 acetylglucosaminyltransferase activity 3 15 0 3116 0.17 1 0.00096 0 3.1 1.6e-07 < 0.001 GPI anchor metabolism/glycosylphosphatidylinositol metabolism 4 14 10 3106 0.22 0.29 0.0045 0.0032 2 7.4e-07 < 0.001 UDP-glycosyltransferase activity 3 15 2 3114 0.17 0.6 0.0016 0.00064 2.4 1.6e-06 < 0.001 protein lipidation 3 15 2 3114 0.17 0.6 0.0016 0.00064 2.4 1.6e-06 < 0.001 lipoprotein biosynthesis 4 14 13 3103 0.22 0.24 0.0054 0.0042 1.9 1.7e-06 < 0.001 transferase activity, transferring hexosyl groups/hexosyltransferase 3 15 3 3113 0.17 0.5 0.0019 0.00096 2.3 3.1e-06 < 0.001 phospholipid biosynthesis 3 15 3 3113 0.17 0.5 0.0019 0.00096 2.3 3.1e-06 < 0.001 glycerophospholipid metabolism/phosphoglyceride metabolism 3 15 3 3113 0.17 0.5 0.0019 0.00096 2.3 3.1e-06 < 0.001 glycerophospholipid biosynthesis/phosphoglyceride biosynthesis 3 15 3 3113 0.17 0.5 0.0019 0.00096 2.3 3.1e-06 < 0.001 lipoprotein metabolism 3 15 3 3113 0.17 0.5 0.0019 0.00096 2.3 3.1e-06 < 0.001 phosphoinositide metabolism 3 15 3 3113 0.17 0.5 0.0019 0.00096 2.3 3.1e-06 < 0.001 phosphoinositide biosynthesis 4 14 20 3096 0.22 0.17 0.0077 0.0064 1.7 7.5e-06 0.001 transferase activity, transferring glycosyl groups/glycosyltransferase 3 15 6 3110 0.17 0.33 0.0029 0.0019 2 1.3e-05 0.002 phospholipid metabolism 3 15 6 3110 0.17 0.33 0.0029 0.0019 2 1.3e-05 0.002 membrane lipid biosynthesis 3 15 8 3108 0.17 0.27 0.0035 0.0026 1.9 2.6e-05 0.005 transmembrane receptor protein serine/threonine kinase signaling pathway/transmembrane receptor protein serine/threonine kinase signalling pathway 4 14 34 3082 0.22 0.11 0.012 0.011 1.4 5e-05 0.013 enzyme linked receptor protein signaling pathway/enzyme linked receptor protein signalling pathway 3 15 22 3094 0.17 0.12 0.008 0.0071 1.5 0.00034 0.068 membrane lipid metabolism 3 15 26 3090 0.17 0.1 0.0093 0.0083 1.4 0.00053 0.096 lipid biosynthesis Interactions within complex: 652 652 652 657 657 657 657 4086 2885 2885 2885 6352 2885 10253 4086 4086 4086 4090 4086 9091 4086 10140 4090 6626 4090 10140 4090 11338 5277 5279 5277 5283 5277 9091 5279 5283 5279 9091 5283 9091 6352 6352 6626 6626 8576 8576 8576 54507 10253 54507 11338 26511 26511 117144 54507 117144 =============================================================================== Complex CCSB-HI1-union-LCI.10 Size of complex: 83 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 18 65 82 2969 0.22 0.18 0.032 0.027 1 3.5e-11 < 0.001 response to wounding 27 56 224 2827 0.33 0.11 0.08 0.073 0.79 5.8e-11 < 0.001 response to external stimulus 16 67 84 2967 0.19 0.16 0.032 0.028 0.93 3.1e-09 < 0.001 extracellular region/extracellular 30 53 350 2701 0.36 0.079 0.12 0.11 0.64 8.5e-09 < 0.001 organismal physiological process 17 66 118 2933 0.2 0.13 0.043 0.039 0.81 4e-08 < 0.001 response to external biotic stimulus 16 67 111 2940 0.19 0.13 0.041 0.036 0.81 1.1e-07 0.001 response to pest, pathogen or parasite/response to pest/pathogen/parasite 10 73 38 3013 0.12 0.21 0.015 0.012 1 2.8e-07 0.001 extracellular matrix 23 60 256 2795 0.28 0.082 0.089 0.084 0.63 3.8e-07 0.001 response to stress 21 62 244 2807 0.25 0.079 0.085 0.08 0.6 2.7e-06 0.001 morphogenesis 8 75 28 3023 0.096 0.22 0.011 0.0092 1.1 2.9e-06 0.001 taxis 15 68 129 2922 0.18 0.1 0.046 0.042 0.71 3.4e-06 0.001 immune response 29 54 440 2611 0.35 0.062 0.15 0.14 0.51 3.7e-06 0.001 response to stimulus 7 76 21 3030 0.084 0.25 0.0089 0.0069 1.1 5.3e-06 0.001 hemostasis 7 76 21 3030 0.084 0.25 0.0089 0.0069 1.1 5.3e-06 0.001 wound healing 7 76 22 3029 0.084 0.24 0.0093 0.0072 1.1 6.9e-06 0.001 coagulation/clotting 11 72 76 2975 0.13 0.13 0.028 0.025 0.79 1.3e-05 0.001 response to abiotic stimulus 7 76 27 3024 0.084 0.21 0.011 0.0088 1 2.1e-05 0.004 regulation of body fluids 17 66 197 2854 0.2 0.079 0.068 0.065 0.58 2.9e-05 0.005 defense response/defence response 19 64 248 2803 0.23 0.071 0.085 0.081 0.53 4.3e-05 0.005 response to biotic stimulus 17 66 207 2844 0.2 0.076 0.071 0.068 0.56 5.2e-05 0.007 organ development/development of an organ 8 75 45 3006 0.096 0.15 0.017 0.015 0.87 5.8e-05 0.01 response to chemical substance 21 62 315 2736 0.25 0.062 0.11 0.1 0.47 0.00011 0.025 development 8 75 50 3001 0.096 0.14 0.019 0.016 0.83 0.00011 0.025 enzyme inhibitor activity 5 78 15 3036 0.06 0.25 0.0064 0.0049 1.1 0.00013 0.028 serine-type endopeptidase activity/serine protease activity 5 78 17 3034 0.06 0.23 0.007 0.0056 1.1 0.00021 0.046 serine-type peptidase activity/serine protease 33 50 670 2381 0.4 0.047 0.22 0.22 0.37 0.00024 0.049 cell communication 4 79 9 3042 0.048 0.31 0.0041 0.0029 1.3 0.00027 0.055 blood coagulation/blood clotting 15 68 195 2856 0.18 0.071 0.067 0.064 0.52 0.00031 0.06 organogenesis 3 80 3 3048 0.036 0.5 0.0019 0.00098 1.6 0.00034 0.078 metalloendopeptidase activity/metalloprotease/metalloproteinase 12 71 133 2918 0.14 0.083 0.046 0.044 0.58 0.00034 0.078 cellular macromolecule catabolism 8 75 63 2988 0.096 0.11 0.023 0.021 0.72 0.00047 0.091 endopeptidase activity/endoprotease/proteinase 4 79 11 3040 0.048 0.27 0.0048 0.0036 1.2 0.0005 0.099 chemokine receptor binding/chemokine receptor ligand 4 79 11 3040 0.048 0.27 0.0048 0.0036 1.2 0.0005 0.099 G-protein-coupled receptor binding/G-protein-coupled receptor ligand 12 71 139 2912 0.14 0.079 0.048 0.046 0.56 0.0005 0.099 macromolecule catabolism Interactions within complex: 273 7448 273 8851 301 3856 301 6282 309 6271 309 6285 488 5350 488 6271 811 2157 811 5327 929 1604 929 3689 929 3959 960 4318 960 4771 960 5552 1280 1280 1280 1634 1280 6678 1280 7040 1288 1634 1288 4318 1604 1604 1634 7040 2139 6495 2139 11030 2157 5264 2157 5624 2157 5627 2266 2266 2266 3383 2266 5104 2266 7448 2288 2288 2288 5264 2597 2597 2597 5584 2597 6277 2919 2919 2919 3577 2919 3579 2920 2920 2920 3577 2920 3579 3002 3002 3002 5552 3383 3383 3383 3689 3577 5473 3577 6374 3579 3579 3579 5473 3579 6374 3856 5327 3959 3959 4312 4312 4312 63827 4313 4313 4313 7040 4313 7078 4313 63827 4318 4318 4318 6374 4318 7078 4687 4687 4687 9618 4771 4771 4771 6895 4792 7278 4792 9883 4792 10376 4792 23291 5054 5054 5054 5327 5054 7448 5104 5327 5104 5328 5104 5624 5191 5195 5191 5264 5195 5195 5236 6271 5236 6285 5264 5264 5269 5328 5269 5624 5327 5327 5327 5328 5327 6678 5328 5328 5350 5350 5350 6271 5473 5473 5584 50855 5624 5624 5624 5627 5817 6990 5817 7448 6118 6119 6118 6774 6119 6119 6271 6271 6271 6285 6271 6286 6271 27101 6277 6277 6277 6285 6277 11319 6277 27101 6282 6282 6282 6285 6285 6285 6285 11319 6285 27101 6286 6286 6286 27101 6477 6477 6477 7278 6477 7321 6477 10376 6477 27101 6495 6495 6495 7088 6678 6678 6678 7040 6774 9111 6895 6895 6895 9618 6990 6990 6990 54997 7040 7040 7040 7448 7088 7088 7278 9111 7321 7337 7337 7337 7448 7448 8851 8851 9111 11117 9883 11030 10363 10363 10363 54997 11030 11030 11117 11117 11117 66036 23291 23291 50855 50855 54997 54997 66036 66036 =============================================================================== Complex CCSB-HI1-union-LCI.01 Size of complex: 7 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 6 1 10 3117 0.86 0.38 0.0051 0.0032 3.1 4.3e-14 < 0.001 nucleolus 7 0 41 3086 1 0.15 0.015 0.013 3 1.3e-13 < 0.001 RNA splicing, via transesterification reactions 7 0 41 3086 1 0.15 0.015 0.013 3 1.3e-13 < 0.001 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile/lariat RNA formation 7 0 43 3084 1 0.14 0.016 0.014 3 1.7e-13 < 0.001 RNA splicing 7 0 46 3081 1 0.13 0.017 0.015 3 2.6e-13 < 0.001 mRNA processing 7 0 67 3060 1 0.095 0.024 0.021 2.8 3.1e-12 < 0.001 ribonucleoprotein complex/RNP 7 0 67 3060 1 0.095 0.024 0.021 2.8 3.1e-12 < 0.001 mRNA metabolism 7 0 98 3029 1 0.067 0.034 0.031 2.7 3.9e-11 < 0.001 RNA processing 7 0 122 3005 1 0.054 0.041 0.039 2.6 1.7e-10 < 0.001 RNA metabolism 7 0 195 2932 1 0.035 0.064 0.062 2.4 4.2e-09 < 0.001 nucleus 7 0 398 2729 1 0.017 0.13 0.13 2 5.8e-07 < 0.001 protein complex 7 0 423 2704 1 0.016 0.14 0.14 2 8.8e-07 < 0.001 biopolymer metabolism 6 1 264 2863 0.86 0.022 0.086 0.084 1.7 2.5e-06 < 0.001 non-membrane-bound organelle 6 1 264 2863 0.86 0.022 0.086 0.084 1.7 2.5e-06 < 0.001 intracellular non-membrane-bound organelle 7 0 600 2527 1 0.012 0.19 0.19 1.8 9.9e-06 < 0.001 nucleic acid binding 7 0 709 2418 1 0.0098 0.23 0.23 1.7 3.2e-05 0.005 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 7 0 1153 1974 1 0.006 0.37 0.37 1.4 0.00094 0.094 intracellular membrane-bound organelle 7 0 1153 1974 1 0.006 0.37 0.37 1.4 0.00094 0.094 membrane-bound organelle Interactions within complex: 6606 6606 6606 11157 6606 23658 6606 25804 6606 27257 6606 27258 6606 57819 11157 23658 11157 25804 11157 27257 11157 27258 11157 57819 23658 25804 23658 27257 23658 27258 23658 57819 25804 27257 25804 27258 25804 57819 27257 27258 27257 57819 27258 57819 =============================================================================== Complex CCSB-HI1-union-LCI.37 Size of complex: 10 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 7 3 184 2940 0.7 0.037 0.061 0.059 1.5 2.9e-07 < 0.001 phosphate metabolism 7 3 185 2939 0.7 0.036 0.061 0.059 1.5 3e-07 < 0.001 phosphorus metabolism 5 5 60 3064 0.5 0.077 0.021 0.019 1.7 7.6e-07 < 0.001 cellular carbohydrate metabolism 5 5 61 3063 0.5 0.076 0.021 0.02 1.7 8.3e-07 < 0.001 carbohydrate metabolism 6 4 153 2971 0.6 0.038 0.051 0.049 1.4 2.8e-06 < 0.001 phosphorylation 6 4 158 2966 0.6 0.037 0.052 0.051 1.4 3.3e-06 < 0.001 phosphotransferase activity, alcohol group as acceptor 4 6 34 3090 0.4 0.11 0.012 0.011 1.8 3.7e-06 < 0.001 hexose metabolism 4 6 34 3090 0.4 0.11 0.012 0.011 1.8 3.7e-06 < 0.001 monosaccharide metabolism 10 0 918 2206 1 0.011 0.3 0.29 1.7 5e-06 < 0.001 catalytic activity/enzyme activity 6 4 175 2949 0.6 0.033 0.058 0.056 1.4 5.9e-06 < 0.001 kinase activity/phosphokinase 2 8 0 3124 0.2 1 0.00064 0 3.3 9.2e-06 0.004 pyruvate dehydrogenase activity 7 3 315 2809 0.7 0.022 0.1 0.1 1.3 1e-05 0.005 transferase activity 7 3 336 2788 0.7 0.02 0.11 0.11 1.2 1.6e-05 0.005 protein modification 9 1 731 2393 0.9 0.012 0.24 0.23 1.3 1.7e-05 0.006 cellular macromolecule metabolism 4 6 54 3070 0.4 0.069 0.019 0.017 1.6 2e-05 0.006 alcohol metabolism 6 4 225 2899 0.6 0.026 0.074 0.072 1.3 2.5e-05 0.006 transferase activity, transferring phosphorus-containing groups 9 1 770 2354 0.9 0.012 0.25 0.25 1.3 2.7e-05 0.006 macromolecule metabolism 2 8 1 3123 0.2 0.67 0.00096 0.00032 2.8 2.7e-05 0.012 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor/oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor 6 4 247 2877 0.6 0.024 0.081 0.079 1.2 4.2e-05 0.013 adenyl nucleotide binding 2 8 6 3118 0.2 0.25 0.0026 0.0019 2.1 0.00025 0.054 oxidoreductase activity, acting on the aldehyde or oxo group of donors 6 4 347 2777 0.6 0.017 0.11 0.11 1.1 0.00028 0.058 purine nucleotide binding 6 4 348 2776 0.6 0.017 0.11 0.11 1.1 0.00028 0.058 nucleotide binding 3 7 42 3082 0.3 0.067 0.014 0.013 1.5 0.00031 0.058 energy derivation by oxidation of organic compounds/chemoorganotrophy 4 6 128 2996 0.4 0.03 0.042 0.041 1.2 0.00052 0.082 protein kinase activity Interactions within complex: 2534 2534 2534 7297 2932 2932 2932 3611 2932 5770 3611 5163 5160 5160 5160 5162 5162 5162 5162 8050 5163 5164 5164 8050 5770 7297 7297 7297 =============================================================================== Complex CCSB-HI1-union-LCI.17 Size of complex: 23 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 7 16 76 3035 0.3 0.084 0.026 0.024 1.3 1.2e-06 < 0.001 response to DNA damage stimulus 7 16 80 3031 0.3 0.08 0.028 0.026 1.2 1.7e-06 < 0.001 response to endogenous stimulus 3 20 6 3105 0.13 0.33 0.0029 0.0019 1.9 2.8e-05 0.004 maintenance of fidelity during DNA-dependent DNA replication 4 19 29 3082 0.17 0.12 0.011 0.0093 1.4 7.8e-05 0.021 DNA-dependent DNA replication 4 19 32 3079 0.17 0.11 0.011 0.01 1.3 0.00011 0.026 DNA repair 4 19 33 3078 0.17 0.11 0.012 0.011 1.3 0.00012 0.026 DNA replication/DNA biosynthesis/DNA synthesis 7 16 165 2946 0.3 0.041 0.055 0.053 0.91 0.00015 0.037 DNA metabolism 5 18 77 3034 0.22 0.061 0.026 0.025 1.1 0.00025 0.046 transcription cofactor activity/transcriptional co-regulator 13 10 703 2408 0.57 0.018 0.23 0.23 0.64 0.00047 0.078 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 2 21 3 3108 0.087 0.4 0.0016 0.00096 2 0.00051 0.094 DNA damage response, signal transduction Interactions within complex: 328 4595 328 5111 387 387 387 396 387 10567 396 396 1478 10923 1478 29979 3364 5111 3364 5883 3398 3398 3398 6925 3398 9242 3399 3399 3399 6925 3399 11036 4436 5111 4436 9156 4595 5111 4841 4841 4841 5111 5111 5111 5111 5883 5111 9156 5111 10923 5864 5864 5864 5866 5864 10567 5864 117177 5866 5866 5866 117177 6925 6925 6925 9242 10567 10567 10567 125170 10923 10923 10923 11036 29979 29979 29979 125170 =============================================================================== Complex CCSB-HI1-union-LCI.34 Size of complex: 3 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 0 33 3098 1 0.083 0.011 0.011 2.8 1.4e-06 < 0.001 translation factor activity, nucleic acid binding 3 0 35 3096 1 0.079 0.012 0.011 2.8 1.6e-06 < 0.001 translation regulator activity 3 0 53 3078 1 0.054 0.018 0.017 2.6 5.4e-06 0.001 translation/protein translation 3 0 75 3056 1 0.038 0.025 0.024 2.5 1.5e-05 0.002 protein biosynthesis 3 0 122 3009 1 0.024 0.04 0.039 2.2 6.2e-05 0.007 macromolecule biosynthesis 3 0 182 2949 1 0.016 0.059 0.058 2.1 0.0002 0.017 cellular biosynthesis 3 0 199 2932 1 0.015 0.064 0.064 2 0.00026 0.021 biosynthesis/anabolism Interactions within complex: 8890 8890 8890 8891 8890 8892 8891 8892 =============================================================================== Complex CCSB-HI1-union-LCI.09 Size of complex: 17 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 15 2 553 2564 0.88 0.026 0.18 0.18 1.5 6.1e-10 < 0.001 membrane 10 7 231 2886 0.59 0.041 0.077 0.074 1.2 7.3e-08 < 0.001 plasma membrane/bacterial inner membrane/cell membrane/cytoplasmic membrane/juxtamembrane/plasmalemma 4 13 10 3107 0.24 0.29 0.0045 0.0032 2 5.7e-07 0.001 clathrin coat/clathrin cage 5 12 31 3086 0.29 0.14 0.011 0.0099 1.6 8.4e-07 0.001 cytoplasmic vesicle 4 13 17 3100 0.24 0.19 0.0067 0.0055 1.8 3.4e-06 0.002 Golgi apparatus/Golgi complex/Golgi ribbon 4 13 18 3099 0.24 0.18 0.007 0.0058 1.7 4.1e-06 0.002 membrane coat 4 13 18 3099 0.24 0.18 0.007 0.0058 1.7 4.1e-06 0.002 vesicle coat 4 13 18 3099 0.24 0.18 0.007 0.0058 1.7 4.1e-06 0.002 coated membrane 4 13 21 3096 0.24 0.16 0.008 0.0067 1.7 7e-06 0.002 clathrin-coated vesicle 3 14 5 3112 0.18 0.38 0.0026 0.0016 2.1 7.3e-06 0.002 trans-Golgi network transport vesicle/TGN transport vesicle 3 14 6 3111 0.18 0.33 0.0029 0.0019 2.1 1.1e-05 0.003 transport vesicle/secretory vesicle 3 14 6 3111 0.18 0.33 0.0029 0.0019 2.1 1.1e-05 0.003 clathrin vesicle coat 3 14 6 3111 0.18 0.33 0.0029 0.0019 2.1 1.1e-05 0.003 Golgi vesicle 6 11 113 3004 0.35 0.05 0.038 0.036 1.2 2.3e-05 0.004 protein transport/enzyme transport 4 13 30 3087 0.24 0.12 0.011 0.0096 1.5 2.5e-05 0.004 coated vesicle 5 12 87 3030 0.29 0.054 0.029 0.028 1.2 9.2e-05 0.019 vesicle-mediated transport/nonselective vesicle transport 6 11 155 2962 0.35 0.037 0.051 0.05 1 0.00013 0.021 intracellular transport 8 9 330 2787 0.47 0.024 0.11 0.11 0.88 0.00017 0.037 transport 6 11 168 2949 0.35 0.034 0.056 0.054 1 0.0002 0.037 establishment of protein localization/protein positioning/protein recruitment 6 11 169 2948 0.35 0.034 0.056 0.054 0.99 0.00021 0.037 protein localization 6 11 173 2944 0.35 0.034 0.057 0.056 0.98 0.00023 0.038 intrinsic to plasma membrane 8 9 377 2740 0.47 0.021 0.12 0.12 0.81 0.00043 0.077 establishment of localization 8 9 380 2737 0.47 0.021 0.12 0.12 0.81 0.00045 0.079 localization/establishment and maintenance of position/establishment and maintenance of substrate location/positioning 6 11 201 2916 0.35 0.029 0.066 0.064 0.91 0.00052 0.082 integral to membrane/transmembrane Interactions within complex: 163 9685 163 10053 164 164 164 375 164 1174 164 9685 164 10053 375 375 375 9266 382 409 382 9266 409 9266 1174 10053 2065 2065 2065 3732 3109 3122 3109 3732 3122 3732 3688 3732 3688 4179 3688 7106 3688 10618 4179 4179 4179 7106 10053 10618 =============================================================================== Complex CCSB-HI1-union-LCI.20 Size of complex: 15 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 12 1 3118 0.2 0.75 0.0013 0.00032 2.8 3.5e-07 < 0.001 caveola/caveolae 6 9 235 2884 0.4 0.025 0.077 0.075 0.92 0.00054 0.091 plasma membrane/bacterial inner membrane/cell membrane/cytoplasmic membrane/juxtamembrane/plasmalemma Interactions within complex: 70 1072 70 1756 70 60312 71 71 71 1072 156 408 156 857 156 5037 156 5579 156 5957 408 5744 408 5745 857 858 857 2319 857 5957 858 2319 1756 1756 5037 5037 5579 60312 5744 5745 60312 60312 =============================================================================== Complex CCSB-HI1-union-LCI.27 Size of complex: 3 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 1 3 3128 0.67 0.4 0.0016 0.00096 3.2 6.1e-06 < 0.001 rhythmic process Interactions within complex: 1407 5187 1407 8863 5187 8863 =============================================================================== Complex CCSB-HI1-union-LCI.16 Size of complex: 45 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 27 18 712 2377 0.6 0.037 0.24 0.23 0.7 1.5e-07 < 0.001 regulation of cellular process 28 17 784 2305 0.62 0.034 0.26 0.25 0.68 2.6e-07 < 0.001 regulation of biological process/regulation 7 38 31 3058 0.16 0.18 0.012 0.01 1.3 7e-07 < 0.001 interphase of mitotic cell cycle 7 38 31 3058 0.16 0.18 0.012 0.01 1.3 7e-07 < 0.001 interphase/karyostasis/resting phase 25 20 674 2415 0.56 0.036 0.22 0.22 0.65 1.1e-06 < 0.001 regulation of cellular physiological process 9 36 72 3017 0.2 0.11 0.026 0.023 1 1.4e-06 < 0.001 mitotic cell cycle 13 32 180 2909 0.29 0.067 0.062 0.058 0.83 1.6e-06 < 0.001 cell cycle/cell-division cycle 7 38 41 3048 0.16 0.15 0.015 0.013 1.2 3.7e-06 0.001 cell division 25 20 721 2368 0.56 0.034 0.24 0.23 0.61 3.9e-06 0.001 regulation of physiological process 11 34 137 2952 0.24 0.074 0.047 0.044 0.85 4.6e-06 0.001 programmed cell death 11 34 140 2949 0.24 0.073 0.048 0.045 0.84 5.6e-06 0.001 cell death 11 34 144 2945 0.24 0.071 0.049 0.047 0.83 7.2e-06 0.001 death 43 2 2198 891 0.96 0.019 0.72 0.71 0.85 4.5e-05 0.007 cellular process 8 37 91 2998 0.18 0.081 0.032 0.029 0.87 6.1e-05 0.012 regulation of programmed cell death 8 37 99 2990 0.18 0.075 0.034 0.032 0.83 0.00011 0.018 apoptosis/type I programmed cell death 14 31 329 2760 0.31 0.041 0.11 0.11 0.59 0.00019 0.038 protein modification Interactions within complex: 573 2908 573 5925 862 862 862 8841 862 220766 894 1019 894 1021 958 8767 958 10758 958 51567 983 1163 983 1647 983 2068 983 2176 983 8900 983 10912 983 64689 1019 5925 1021 1021 1163 1163 1163 6502 1647 5465 1647 10912 2068 2068 2175 2175 2175 2176 2874 2874 2874 8900 2908 2908 2908 5452 2908 7341 4000 4000 4000 5925 4605 4605 4605 6502 4605 8900 5452 5452 5465 5465 5465 10912 5465 246329 5467 5467 5467 10912 5905 5905 5905 6613 5905 7341 5925 5925 5925 5928 5925 6015 5925 6689 5925 8841 5925 8900 5925 10399 5925 10403 5928 8841 6015 6015 6500 6500 6500 6502 6500 8454 6500 9978 6500 84893 6502 6502 6502 8454 6613 6613 6689 6689 7341 7341 7341 51567 8379 8379 8379 10403 8454 8454 8454 9616 8454 9978 8454 84893 8767 10392 8841 8841 8900 10399 9616 9616 9978 84893 10392 10392 10758 10758 64689 64689 220766 220766 246329 246329 =============================================================================== Complex CCSB-HI1-union-LCI.19 Size of complex: 29 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 5 24 20 3085 0.17 0.2 0.008 0.0064 1.5 2.2e-06 < 0.001 mitosis 4 25 9 3096 0.14 0.31 0.0041 0.0029 1.8 4e-06 < 0.001 microtubule cytoskeleton organization and biogenesis 6 23 45 3060 0.21 0.12 0.016 0.014 1.3 4.9e-06 < 0.001 M phase of mitotic cell cycle/M-phase of mitotic cell cycle 5 24 26 3079 0.17 0.16 0.0099 0.0084 1.4 6.8e-06 < 0.001 microtubule-based process 3 26 2 3103 0.1 0.6 0.0016 0.00064 2.2 7e-06 < 0.001 GTP metabolism 3 26 2 3103 0.1 0.6 0.0016 0.00064 2.2 7e-06 < 0.001 pyrimidine ribonucleoside triphosphate metabolism 3 26 2 3103 0.1 0.6 0.0016 0.00064 2.2 7e-06 < 0.001 pyrimidine ribonucleotide metabolism 3 26 2 3103 0.1 0.6 0.0016 0.00064 2.2 7e-06 < 0.001 pyrimidine nucleotide biosynthesis 3 26 2 3103 0.1 0.6 0.0016 0.00064 2.2 7e-06 < 0.001 CTP metabolism 3 26 2 3103 0.1 0.6 0.0016 0.00064 2.2 7e-06 < 0.001 UTP metabolism 3 26 2 3103 0.1 0.6 0.0016 0.00064 2.2 7e-06 < 0.001 pyrimidine ribonucleotide biosynthesis 3 26 2 3103 0.1 0.6 0.0016 0.00064 2.2 7e-06 < 0.001 pyrimidine ribonucleoside triphosphate biosynthesis 3 26 3 3102 0.1 0.5 0.0019 0.00097 2.1 1.4e-05 < 0.001 pyrimidine nucleoside triphosphate metabolism 6 23 60 3045 0.21 0.091 0.021 0.019 1.1 2.3e-05 < 0.001 M phase/M-phase 3 26 4 3101 0.1 0.43 0.0022 0.0013 2 2.4e-05 < 0.001 pyrimidine nucleotide metabolism 28 1 1963 1142 0.97 0.014 0.64 0.63 1 3.2e-05 0.001 cellular physiological process/cell growth and/or maintenance/cell physiology 3 26 5 3100 0.1 0.38 0.0026 0.0016 1.9 3.9e-05 0.004 phosphotransferase activity, phosphate group as acceptor 5 24 41 3064 0.17 0.11 0.015 0.013 1.2 5e-05 0.004 microtubule cytoskeleton 3 26 6 3099 0.1 0.33 0.0029 0.0019 1.8 5.8e-05 0.01 nucleobase, nucleoside, nucleotide kinase activity 6 23 75 3030 0.21 0.074 0.026 0.024 1 7.3e-05 0.01 mitotic cell cycle 3 26 7 3098 0.1 0.3 0.0032 0.0023 1.7 8.2e-05 0.014 nucleoside triphosphate biosynthesis 3 26 7 3098 0.1 0.3 0.0032 0.0023 1.7 8.2e-05 0.014 purine nucleoside triphosphate biosynthesis 3 26 7 3098 0.1 0.3 0.0032 0.0023 1.7 8.2e-05 0.014 ribonucleoside triphosphate biosynthesis 3 26 7 3098 0.1 0.3 0.0032 0.0023 1.7 8.2e-05 0.014 purine ribonucleoside triphosphate biosynthesis 3 26 8 3097 0.1 0.27 0.0035 0.0026 1.7 0.00011 0.028 ribonucleoside triphosphate metabolism 3 26 8 3097 0.1 0.27 0.0035 0.0026 1.7 0.00011 0.028 purine ribonucleoside triphosphate metabolism 3 26 8 3097 0.1 0.27 0.0035 0.0026 1.7 0.00011 0.028 purine nucleoside triphosphate metabolism 3 26 9 3096 0.1 0.25 0.0038 0.0029 1.6 0.00015 0.031 nucleoside triphosphate metabolism 3 26 10 3095 0.1 0.23 0.0041 0.0032 1.6 0.00019 0.039 purine ribonucleotide biosynthesis 3 26 10 3095 0.1 0.23 0.0041 0.0032 1.6 0.00019 0.039 purine nucleotide biosynthesis 3 26 11 3094 0.1 0.21 0.0045 0.0035 1.6 0.00024 0.042 purine nucleotide metabolism 3 26 11 3094 0.1 0.21 0.0045 0.0035 1.6 0.00024 0.042 pore complex/pore 3 26 11 3094 0.1 0.21 0.0045 0.0035 1.6 0.00024 0.042 ribonucleotide biosynthesis 3 26 11 3094 0.1 0.21 0.0045 0.0035 1.6 0.00024 0.042 purine ribonucleotide metabolism 8 21 185 2920 0.28 0.041 0.062 0.06 0.79 0.00025 0.06 cell cycle/cell-division cycle 3 26 12 3093 0.1 0.2 0.0048 0.0039 1.5 0.0003 0.07 ribonucleotide metabolism 9 20 261 2844 0.31 0.033 0.086 0.084 0.7 0.00049 0.09 non-membrane-bound organelle 9 20 261 2844 0.31 0.033 0.086 0.084 0.7 0.00049 0.09 intracellular non-membrane-bound organelle Interactions within complex: 991 996 991 4085 996 4085 1104 1104 1104 3839 1104 5757 1104 5901 1104 8498 2059 2059 2059 7965 2059 26258 3001 3148 3001 6418 3148 6418 3839 7052 4085 4085 4085 9587 4134 7280 4134 57787 4830 4830 4830 4832 4830 4833 4830 6418 4832 4832 4832 6449 4833 4833 4833 9319 5071 7314 5071 7965 5071 9319 5757 5901 5757 6418 5901 8498 6449 6449 6449 6860 6860 6860 7052 7052 7052 7280 7189 7314 7189 9020 7280 57787 7965 7965 9020 9020 9319 9319 9319 9587 26258 26258 =============================================================================== Complex CCSB-HI1-union-LCI.07 Size of complex: 4 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 2 0 3130 0.5 1 0.00064 0 3.8 1.2e-06 < 0.001 interleukin-2 binding/IL-2 binding 2 2 2 3128 0.5 0.5 0.0013 0.00064 3.1 7.3e-06 0.001 interleukin receptor activity/IL receptor 2 2 4 3126 0.5 0.33 0.0019 0.0013 2.8 1.8e-05 0.002 interleukin binding/IL binding 2 2 7 3123 0.5 0.22 0.0029 0.0022 2.6 4.4e-05 0.005 growth factor binding 2 2 8 3122 0.5 0.2 0.0032 0.0026 2.6 5.5e-05 0.006 hematopoietin/interferon-class (D200-domain) cytokine receptor activity 2 2 15 3115 0.5 0.12 0.0054 0.0048 2.3 0.00017 0.016 cytokine binding 4 0 383 2747 1 0.01 0.12 0.12 1.8 0.00023 0.019 signal transducer activity 2 2 24 3106 0.5 0.077 0.0083 0.0077 2.1 0.00039 0.029 positive regulation of enzyme activity 2 2 31 3099 0.5 0.061 0.011 0.0099 2 0.00064 0.047 receptor signaling protein activity/receptor signalling protein activity Interactions within complex: 3560 3561 3560 6464 3560 6772 3561 6464 3561 6772 6772 6772 =============================================================================== Complex CCSB-HI1-union-LCI.15 Size of complex: 31 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 13 18 135 2968 0.42 0.088 0.047 0.044 1.2 3.4e-10 < 0.001 programmed cell death 13 18 138 2965 0.42 0.086 0.048 0.044 1.2 4.4e-10 < 0.001 cell death 13 18 142 2961 0.42 0.084 0.049 0.046 1.2 6.1e-10 < 0.001 death 10 21 97 3006 0.32 0.093 0.034 0.031 1.2 3.4e-08 < 0.001 apoptosis/type I programmed cell death 9 22 90 3013 0.29 0.091 0.032 0.029 1.1 2.5e-07 < 0.001 regulation of programmed cell death 8 23 81 3022 0.26 0.09 0.028 0.026 1.1 1.4e-06 < 0.001 regulation of apoptosis 6 25 34 3069 0.19 0.15 0.013 0.011 1.4 1.7e-06 < 0.001 negative regulation of apoptosis 6 25 37 3066 0.19 0.14 0.014 0.012 1.3 2.7e-06 < 0.001 negative regulation of programmed cell death 2 29 0 3103 0.065 1 0.00064 0 2.7 9.5e-05 0.026 diphosphotransferase activity 3 28 13 3090 0.097 0.19 0.0051 0.0042 1.4 0.00045 0.09 cysteine-type endopeptidase activity/thiol endopeptidase Interactions within complex: 87 87 87 1495 87 7518 87 26136 329 840 329 842 329 7186 329 27429 331 331 331 840 331 842 331 27429 331 56616 332 332 332 840 332 842 332 56616 351 351 351 5663 407 1856 407 27232 835 835 835 840 835 1639 840 840 840 1639 840 5663 842 842 1495 5663 1854 1854 1854 9825 1856 1856 1856 7186 1856 9531 3303 5830 3303 7917 3303 8517 3303 9531 5631 5631 5631 5635 5631 51324 5635 5635 5663 5663 5830 5830 7186 7186 7186 9825 7186 51324 7518 7518 7917 9372 7917 55603 8517 8517 9372 55603 26136 26136 27232 27232 27429 56616 56616 56616 =============================================================================== Complex CCSB-HI1-union-LCI.02 Size of complex: 6 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 6 0 27 3101 1 0.18 0.011 0.0086 3.2 8.5e-13 < 0.001 DNA-dependent DNA replication 6 0 31 3097 1 0.16 0.012 0.0099 3.1 1.8e-12 < 0.001 DNA replication/DNA biosynthesis/DNA synthesis 6 0 166 2962 1 0.035 0.055 0.053 2.4 2.5e-08 < 0.001 DNA metabolism 5 1 114 3014 0.83 0.042 0.038 0.036 2 4.2e-07 < 0.001 pyrophosphatase activity 5 1 114 3014 0.83 0.042 0.038 0.036 2 4.2e-07 < 0.001 hydrolase activity, acting on acid anhydrides 5 1 114 3014 0.83 0.042 0.038 0.036 2 4.2e-07 < 0.001 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 6 0 424 2704 1 0.014 0.14 0.14 1.9 6.5e-06 < 0.001 biopolymer metabolism 5 1 248 2880 0.83 0.02 0.081 0.079 1.6 1.9e-05 0.002 adenyl nucleotide binding 3 3 35 3093 0.5 0.079 0.012 0.011 1.9 3.2e-05 0.005 ATPase activity, coupled 3 3 37 3091 0.5 0.075 0.013 0.012 1.9 3.8e-05 0.005 ATPase activity/ATP phosphohydrolase/adenosinetriphosphatase 6 0 601 2527 1 0.0099 0.19 0.19 1.7 5.2e-05 0.009 nucleic acid binding 3 3 51 3077 0.5 0.056 0.017 0.016 1.8 9.3e-05 0.011 chromosome 5 1 348 2780 0.83 0.014 0.11 0.11 1.5 9.6e-05 0.011 purine nucleotide binding 5 1 349 2779 0.83 0.014 0.11 0.11 1.5 9.8e-05 0.011 nucleotide binding 5 1 352 2776 0.83 0.014 0.11 0.11 1.5 0.0001 0.011 hydrolase activity 6 0 710 2418 1 0.0084 0.23 0.23 1.6 0.00014 0.015 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 3 3 98 3030 0.5 0.03 0.032 0.031 1.5 0.00061 0.043 nucleoside-triphosphatase activity/nucleoside triphosphatase activity Interactions within complex: 4172 4175 4172 4176 4172 5000 4175 4175 4176 4176 4176 4998 4176 4999 4176 5000 4998 4999 4998 5000 4999 5000 =============================================================================== Complex CCSB-HI1-union-LCI.08 Size of complex: 21 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 18 1 3112 0.14 0.75 0.0013 0.00032 2.6 1e-06 0.001 amyloid precursor protein metabolism/APP metabolism 3 18 1 3112 0.14 0.75 0.0013 0.00032 2.6 1e-06 0.001 Notch signaling pathway/N signaling pathway/N signalling pathway/Notch signalling pathway 3 18 1 3112 0.14 0.75 0.0013 0.00032 2.6 1e-06 0.001 beta-amyloid metabolism 16 5 796 2317 0.76 0.02 0.26 0.26 0.94 1.9e-06 0.001 regulation of biological process/regulation 3 18 2 3111 0.14 0.6 0.0016 0.00064 2.4 2.6e-06 0.001 glycoprotein catabolism/glycoprotein degradation 10 11 279 2834 0.48 0.035 0.092 0.09 0.97 5.4e-06 0.001 transcription regulator activity 6 15 92 3021 0.29 0.061 0.031 0.03 1.1 3e-05 0.001 transcription factor binding/TF binding 3 18 8 3105 0.14 0.27 0.0035 0.0026 1.8 4.1e-05 0.008 glycoprotein metabolism 7 14 158 2955 0.33 0.042 0.053 0.051 0.98 6.1e-05 0.018 positive regulation of biological process 13 8 686 2427 0.62 0.019 0.22 0.22 0.75 0.0001 0.026 regulation of cellular physiological process 3 18 13 3100 0.14 0.19 0.0051 0.0042 1.6 0.00014 0.046 cysteine-type endopeptidase activity/thiol endopeptidase 5 16 77 3036 0.24 0.061 0.026 0.025 1.1 0.00016 0.047 transcription cofactor activity/transcriptional co-regulator 13 8 726 2387 0.62 0.018 0.24 0.23 0.72 0.00019 0.051 regulation of cellular process 13 8 733 2380 0.62 0.017 0.24 0.24 0.71 0.00021 0.051 regulation of physiological process 5 16 88 3025 0.24 0.054 0.03 0.028 1.1 0.00029 0.075 transcription from RNA polymerase II promoter/transcription from Pol II promoter Interactions within complex: 355 7329 355 8772 642 642 642 7329 823 826 823 831 823 5664 826 831 1385 1390 1385 2963 1385 7528 1385 9457 1385 30818 1390 1390 1390 9457 1390 30818 1870 7528 1870 23429 2963 2963 4286 7329 4286 7942 4286 22797 5664 30818 5664 51107 5664 55851 7528 23429 7942 22797 8772 23429 9457 9457 22797 22797 51107 55851 =============================================================================== Complex CCSB-HI1-union-LCI.36 Size of complex: 4 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 1 33 3097 0.75 0.083 0.011 0.011 2.3 5.5e-06 0.001 DNA repair 3 1 80 3050 0.75 0.036 0.026 0.026 1.9 7e-05 0.006 response to DNA damage stimulus 3 1 84 3046 0.75 0.034 0.028 0.027 1.9 8.1e-05 0.006 response to endogenous stimulus 3 1 169 2961 0.75 0.017 0.055 0.054 1.6 0.00062 0.044 DNA metabolism Interactions within complex: 4350 5886 4350 5887 5710 5886 5710 5887 =============================================================================== Complex CCSB-HI1-union-LCI.05 Size of complex: 21 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 13 8 401 2712 0.62 0.031 0.13 0.13 1 2.3e-07 0.001 transcription, DNA-dependent 13 8 420 2693 0.62 0.03 0.14 0.13 1 4e-07 0.001 transcription 11 10 278 2835 0.52 0.038 0.092 0.089 1 5.2e-07 0.001 transcription regulator activity 12 9 394 2719 0.57 0.03 0.13 0.13 0.96 1.9e-06 0.001 regulation of transcription 12 9 415 2698 0.57 0.028 0.14 0.13 0.93 3.2e-06 0.001 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 12 9 427 2686 0.57 0.027 0.14 0.14 0.92 4.4e-06 0.001 regulation of cellular metabolism 12 9 465 2648 0.57 0.025 0.15 0.15 0.87 1.1e-05 0.002 regulation of metabolism 14 7 685 2428 0.67 0.02 0.22 0.22 0.84 1.6e-05 0.006 regulation of cellular physiological process 9 12 245 2868 0.43 0.035 0.081 0.079 0.95 1.6e-05 0.006 DNA binding 13 8 594 2519 0.62 0.021 0.19 0.19 0.83 2.1e-05 0.006 nucleic acid binding 14 7 725 2388 0.67 0.019 0.24 0.23 0.8 3.2e-05 0.011 regulation of cellular process 14 7 732 2381 0.67 0.019 0.24 0.24 0.8 3.5e-05 0.011 regulation of physiological process 14 7 798 2315 0.67 0.017 0.26 0.26 0.75 9.8e-05 0.034 regulation of biological process/regulation 13 8 703 2410 0.62 0.018 0.23 0.23 0.74 0.00013 0.047 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 16 5 1144 1969 0.76 0.014 0.37 0.37 0.71 0.00029 0.074 intracellular membrane-bound organelle 16 5 1144 1969 0.76 0.014 0.37 0.37 0.71 0.00029 0.074 membrane-bound organelle Interactions within complex: 1488 1488 1488 2275 1911 1912 1911 51460 1912 1912 1912 2275 1912 51460 2275 2275 2275 57144 2275 222546 5990 5991 5990 5992 5990 222546 5991 5991 5991 5992 5991 222546 7572 51282 7572 54925 7572 55663 10127 51282 10127 51684 10127 55663 22981 84445 22981 170082 23650 23650 23650 84445 51282 54925 51282 55888 51684 55663 54925 54925 54925 55663 54925 55888 55888 170082 57144 84445 =============================================================================== Complex CCSB-HI1-union-LCI.31 Size of complex: 3 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 0 45 3086 1 0.062 0.015 0.014 2.7 3.4e-06 0.001 RNA splicing, via transesterification reactions 3 0 45 3086 1 0.062 0.015 0.014 2.7 3.4e-06 0.001 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile/lariat RNA formation 3 0 47 3084 1 0.06 0.016 0.015 2.7 3.8e-06 0.002 RNA splicing 3 0 50 3081 1 0.057 0.017 0.016 2.6 4.6e-06 0.002 mRNA processing 3 0 71 3060 1 0.041 0.024 0.023 2.5 1.3e-05 0.004 ribonucleoprotein complex/RNP 3 0 71 3060 1 0.041 0.024 0.023 2.5 1.3e-05 0.004 mRNA metabolism 3 0 102 3029 1 0.029 0.034 0.033 2.3 3.7e-05 0.006 RNA processing 3 0 126 3005 1 0.023 0.041 0.04 2.2 6.8e-05 0.014 RNA metabolism 2 1 14 3117 0.67 0.12 0.0051 0.0045 2.6 7.3e-05 0.015 nucleolus 3 0 199 2932 1 0.015 0.064 0.064 2 0.00026 0.023 nucleus 3 0 267 2864 1 0.011 0.086 0.085 1.9 0.00063 0.044 non-membrane-bound organelle 3 0 267 2864 1 0.011 0.086 0.085 1.9 0.00063 0.044 intracellular non-membrane-bound organelle Interactions within complex: 6632 6633 6632 11218 6633 11218 =============================================================================== Complex CCSB-HI1-union-LCI.28 Size of complex: 15 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 12 7 3112 0.2 0.3 0.0032 0.0022 2.1 1e-05 0.001 vesicle docking 3 12 10 3109 0.2 0.23 0.0041 0.0032 1.9 2.5e-05 0.004 exocytosis/nonselective vesicle exocytosis/secretion/vesicle exocytosis 4 11 43 3076 0.27 0.085 0.015 0.014 1.4 5.4e-05 0.007 secretory pathway 4 11 52 3067 0.27 0.071 0.018 0.017 1.4 0.00011 0.016 secretion 4 11 88 3031 0.27 0.043 0.029 0.028 1.1 0.00074 0.099 vesicle-mediated transport/nonselective vesicle transport Interactions within complex: 1020 1020 1020 6812 1315 3135 1315 8615 2130 4637 2130 79869 2189 2189 2189 2553 2189 9189 2553 8615 3135 3135 4637 11051 6616 6812 6616 8676 6812 8615 8615 8615 8676 8676 9189 10174 10174 79869 11051 11051 11051 79869 =============================================================================== Complex CCSB-HI1-union-LCI.25 Size of complex: 13 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 6 7 142 2979 0.46 0.041 0.047 0.045 1.3 1.3e-05 0.002 programmed cell death 6 7 145 2976 0.46 0.04 0.048 0.046 1.2 1.5e-05 0.002 cell death 6 7 149 2972 0.46 0.039 0.049 0.048 1.2 1.7e-05 0.004 death 5 8 84 3037 0.38 0.056 0.028 0.027 1.4 1.8e-05 0.004 regulation of apoptosis 4 9 43 3078 0.31 0.085 0.015 0.014 1.5 2.9e-05 0.005 mitochondrion 5 8 94 3027 0.38 0.051 0.032 0.03 1.3 3e-05 0.005 regulation of programmed cell death 5 8 102 3019 0.38 0.047 0.034 0.033 1.3 4.4e-05 0.005 apoptosis/type I programmed cell death 2 11 1 3120 0.15 0.67 0.00096 0.00032 2.7 4.8e-05 0.01 regulation of survival gene product activity/regulation of survival gene products 4 9 50 3071 0.31 0.074 0.017 0.016 1.5 5e-05 0.01 positive regulation of programmed cell death 3 10 17 3104 0.23 0.15 0.0064 0.0054 1.8 6.1e-05 0.012 apoptotic program 5 8 138 2983 0.38 0.035 0.046 0.044 1.1 0.00018 0.033 positive regulation of cellular process 2 11 4 3117 0.15 0.33 0.0019 0.0013 2.2 0.00024 0.044 anti-apoptosis 5 8 160 2961 0.38 0.03 0.053 0.051 1.1 0.00035 0.056 positive regulation of biological process 3 10 37 3084 0.23 0.075 0.013 0.012 1.4 0.0005 0.071 negative regulation of apoptosis 3 10 40 3081 0.23 0.07 0.014 0.013 1.4 0.00063 0.084 negative regulation of programmed cell death Interactions within complex: 578 598 578 3329 598 637 598 664 598 665 598 22806 598 64112 637 637 664 664 664 665 664 8834 665 665 665 8834 1719 1719 1719 2280 1719 3329 2280 2280 22806 22806 22806 64376 22807 22807 22807 64376 64112 64112 64376 64376 =============================================================================== Complex CCSB-HI1-union-LCI.32 Size of complex: 3 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 1 12 3119 0.67 0.14 0.0045 0.0038 2.6 5.5e-05 0.007 oxygen and reactive oxygen species metabolism/oxygen and ROS metabolism 3 0 189 2942 1 0.016 0.061 0.06 2 0.00023 0.017 transporter activity Interactions within complex: 1535 1536 1535 4688 1536 4688 =============================================================================== Complex CCSB-HI1-union-LCI.04 Size of complex: 13 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 10 3 693 2428 0.77 0.014 0.22 0.22 1 4.5e-05 0.007 cell communication 4 9 50 3071 0.31 0.074 0.017 0.016 1.5 5e-05 0.015 GTPase regulator activity 3 10 17 3104 0.23 0.15 0.0064 0.0054 1.8 6.1e-05 0.016 protein binding, bridging/protein-protein adaptor 3 10 17 3104 0.23 0.15 0.0064 0.0054 1.8 6.1e-05 0.016 hemopoiesis/blood cell formation/haemopoiesis/hematopoiesis 6 7 261 2860 0.46 0.022 0.085 0.084 0.98 0.00037 0.068 response to biotic stimulus 3 10 39 3082 0.23 0.071 0.013 0.012 1.4 0.00058 0.095 cell differentiation 7 6 410 2711 0.54 0.017 0.13 0.13 0.88 0.00059 0.095 signal transduction Interactions within complex: 392 392 392 663 392 998 392 7454 663 663 663 998 868 7409 868 29760 868 30011 920 920 920 952 920 2214 920 27040 952 2214 998 998 998 7409 998 7454 3937 7409 3937 7454 3937 27040 7409 29760 29760 30011 =============================================================================== Complex CCSB-HI1-union-LCI.13 Size of complex: 20 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 17 8 3106 0.15 0.27 0.0035 0.0026 1.9 3.6e-05 0.007 ribosome biogenesis 3 17 8 3106 0.15 0.27 0.0035 0.0026 1.9 3.6e-05 0.007 rRNA metabolism 3 17 13 3101 0.15 0.19 0.0051 0.0042 1.7 0.00012 0.029 ribosome biogenesis and assembly 3 17 17 3097 0.15 0.15 0.0064 0.0055 1.5 0.00024 0.063 ligand-dependent nuclear receptor activity/nuclear hormone receptor 3 17 19 3095 0.15 0.14 0.007 0.0061 1.5 0.00032 0.074 cytoplasm organization and biogenesis 2 18 3 3111 0.1 0.4 0.0016 0.00096 2.1 0.00038 0.094 exoribonuclease activity 2 18 3 3111 0.1 0.4 0.0016 0.00096 2.1 0.00038 0.094 exoribonuclease activity, producing 5'-phosphomonoesters/exoribonuclease activity, producing 5' phosphomonoesters Interactions within complex: 634 634 634 5781 1797 1797 1797 23016 1797 54512 2100 6776 2100 8431 2962 4488 2962 5701 4049 4049 4049 7132 4488 4488 5700 5701 5700 5708 5700 5711 5701 5708 5701 5711 5708 5711 5708 7132 5781 6504 5781 6776 5781 7132 5781 9019 6504 6504 7132 7132 7376 7376 7376 8431 9019 54512 23016 51013 23016 54512 51013 54512 54512 54512 =============================================================================== Complex CCSB-HI1-union-LCI.14 Size of complex: 5 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 2 44 3085 0.6 0.064 0.015 0.014 2 3.1e-05 0.008 secretory pathway 3 2 53 3076 0.6 0.054 0.018 0.017 1.9 5.3e-05 0.008 secretion 3 2 89 3040 0.6 0.033 0.029 0.028 1.7 0.00023 0.025 vesicle-mediated transport/nonselective vesicle transport 2 3 22 3107 0.4 0.083 0.0077 0.007 2 0.00055 0.049 Golgi vesicle transport 4 1 334 2795 0.8 0.012 0.11 0.11 1.4 0.00061 0.052 transport 3 2 125 3004 0.6 0.023 0.041 0.04 1.5 0.00063 0.054 cell fraction 4 1 381 2748 0.8 0.01 0.12 0.12 1.3 0.001 0.072 establishment of localization 4 1 384 2745 0.8 0.01 0.12 0.12 1.3 0.001 0.073 localization/establishment and maintenance of position/establishment and maintenance of substrate location/positioning 3 2 158 2971 0.6 0.019 0.051 0.05 1.4 0.0012 0.08 intracellular transport 3 2 171 2958 0.6 0.017 0.056 0.055 1.4 0.0015 0.096 establishment of protein localization/protein positioning/protein recruitment 3 2 172 2957 0.6 0.017 0.056 0.055 1.4 0.0016 0.098 protein localization Interactions within complex: 6813 6844 6813 8773 6844 8773 8773 9522 8773 10066 9522 9522 9522 10066 =============================================================================== Complex CCSB-HI1-union-LCI.46 Size of complex: 3 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 0 126 3005 1 0.023 0.041 0.04 2.2 6.8e-05 0.011 RNA metabolism 2 1 46 3085 0.67 0.042 0.015 0.015 2 0.00068 0.045 RNA splicing, via transesterification reactions 2 1 46 3085 0.67 0.042 0.015 0.015 2 0.00068 0.045 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile/lariat RNA formation 2 1 48 3083 0.67 0.04 0.016 0.015 2 0.00074 0.047 RNA splicing 2 1 51 3080 0.67 0.038 0.017 0.016 2 0.00083 0.051 mRNA processing Interactions within complex: 5094 5094 5094 5725 5094 55660 5725 5725 55660 55660 =============================================================================== Complex CCSB-HI1-union-LCI.12 Size of complex: 14 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 12 1 3119 0.14 0.67 0.00096 0.00032 2.6 5.5e-05 0.016 transmembrane receptor protein serine/threonine kinase activity Interactions within complex: 90 91 90 655 90 2022 90 3624 90 4093 91 3624 655 2022 1509 1509 1509 5660 2022 3624 2512 2512 2512 4093 3624 3624 4093 5660 4093 9070 4093 22943 4093 64129 4188 4188 4188 22943 4188 64129 5660 5660 9070 84661 84661 84661 =============================================================================== Complex CCSB-HI1-union-LCI.40 Size of complex: 4 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 1 95 3035 0.75 0.031 0.031 0.03 1.9 0.00012 0.019 transcription factor binding/TF binding Interactions within complex: 4089 4089 4089 4205 4089 10987 4205 4205 4282 4282 4282 10987 =============================================================================== Complex CCSB-HI1-union-LCI.38 Size of complex: 4 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 4 0 360 2770 1 0.011 0.12 0.12 1.8 0.00018 0.02 cation binding 4 0 404 2726 1 0.0098 0.13 0.13 1.8 0.00028 0.027 metal ion binding/metal binding 4 0 409 2721 1 0.0097 0.13 0.13 1.8 0.0003 0.027 ion binding Interactions within complex: 310 6281 310 6717 6281 6281 6717 6717 6717 25801 25801 25801 =============================================================================== Complex CCSB-HI1-union-LCI.39 Size of complex: 4 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 2 18 3112 0.5 0.1 0.0064 0.0058 2.2 0.00023 0.023 ligand-dependent nuclear receptor activity/nuclear hormone receptor Interactions within complex: 1475 1475 1475 1514 1514 1514 1514 6256 6256 6256 6256 8856 8856 8856 =============================================================================== Complex CCSB-HI1-union-LCI.42 Size of complex: 3 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 0 267 2864 1 0.011 0.086 0.085 1.9 0.00063 0.035 non-membrane-bound organelle 3 0 267 2864 1 0.011 0.086 0.085 1.9 0.00063 0.035 intracellular non-membrane-bound organelle Interactions within complex: 6635 6635 6635 7414 7408 7408 7408 7414 7414 7414 =============================================================================== Complex CCSB-HI1-union-LCI.29 Size of complex: 8 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 6 13 3113 0.25 0.13 0.0048 0.0042 1.9 0.00059 0.084 polysaccharide binding 2 6 13 3113 0.25 0.13 0.0048 0.0042 1.9 0.00059 0.084 glycosaminoglycan binding 2 6 15 3111 0.25 0.12 0.0054 0.0048 1.9 0.00076 0.09 pattern binding/pattern recognition activity Interactions within complex: 2246 2246 2246 2260 2246 3313 2260 2260 3313 7157 5612 5612 5612 6789 6789 6789 6789 7157 7157 7157 7157 9013 7157 9015 9013 9015 =============================================================================== Complex CCSB-HI1-union-LCI.22 Size of complex: 9 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 6 3 483 2642 0.67 0.012 0.16 0.15 1 0.00077 0.086 cytoplasm Interactions within complex: 875 875 875 9513 1173 9513 1173 151871 9513 9513 9513 10197 9513 10313 9513 22978 9513 57142 9513 151871 9513 283518 10197 10197 10313 10313 10313 57142 22978 22978 151871 151871 283518 283518 =============================================================================== Complex CCSB-HI1-union-LCI.24 Size of complex: 12 Size of universe: 3134 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 10 8 3114 0.17 0.2 0.0032 0.0026 1.9 0.00059 0.096 tubulin binding Interactions within complex: 2113 2114 2113 2625 2114 2625 2625 4005 4005 4005 4005 10919 4005 10982 4005 22924 5478 5478 5478 54458 8985 8985 8985 10919 10919 80764 10982 10982 10982 22924 54458 83755 80764 83755 83755 83755 =============================================================================== Complex CCSB-HI1-union-LCI.35 Size of complex: 10 Interactions within complex: 836 836 836 3059 836 4719 836 4780 3059 63898 4097 4097 4097 4778 4097 4780 4191 4191 4191 4719 4778 4778 4778 4780 4780 5468 5468 5468 6455 6455 6455 63898 =============================================================================== Complex CCSB-HI1-union-LCI.48 Size of complex: 2 Interactions within complex: 4783 4783 4783 10488 10488 10488 =============================================================================== Complex CCSB-HI1-union-LCI.53 Size of complex: 2 Interactions within complex: 7431 7431 7431 57120 57120 57120 =============================================================================== Complex CCSB-HI1-union-LCI.45 Size of complex: 3 Interactions within complex: 919 919 919 6503 6503 6503 6503 6850 6850 6850 =============================================================================== Complex CCSB-HI1-union-LCI.33 Size of complex: 4 Interactions within complex: 3500 3500 3500 23075 4691 4869 4691 23075 4869 23075 =============================================================================== Complex CCSB-HI1-union-LCI.23 Size of complex: 57 Interactions within complex: 58 5216 58 22948 60 60 60 5216 60 5217 60 7170 60 8904 60 23214 60 131034 358 358 358 79734 373 373 373 80308 373 84708 902 2071 902 10534 1017 1017 1017 4088 1635 1635 1635 84708 2071 5705 2203 2203 2203 84708 3603 3603 3603 10534 4088 4088 4088 4149 4088 7704 4088 10401 4088 10691 4149 4149 4800 5451 4800 10513 5050 5050 5050 27111 5050 84708 5092 5092 5092 84708 5216 5216 5216 23214 5217 5217 5451 5451 5451 5970 5705 6095 5705 7138 5914 7704 5914 9325 5970 9325 5970 10401 5970 23421 6095 6095 6303 6303 6303 84708 7138 7138 7138 116225 7170 7170 7170 29844 7704 7704 7704 55068 8904 8904 8904 10016 8904 26292 8904 28952 8904 131034 8996 8996 8996 29844 10016 10016 10016 93487 10016 131034 10087 10087 10087 23421 10513 10513 10534 10534 10534 22948 10691 10691 22934 22934 22934 84708 23214 23636 23421 23421 23421 23647 23636 23636 23647 23647 26292 131034 27111 27111 28952 131034 51074 51074 51074 84708 51076 51076 51076 84708 54550 54550 54550 84708 55068 84708 59349 59349 59349 84708 79734 79734 79734 84708 80308 80308 84708 253980 93487 93487 116225 253980 =============================================================================== Complex CCSB-HI1-union-LCI.26 Size of complex: 3 Interactions within complex: 5590 6714 5590 7529 6714 6714 6714 7529 7529 7529 =============================================================================== Complex CCSB-HI1-union-LCI.47 Size of complex: 3 Interactions within complex: 3251 3251 3251 55093 55093 79077 79077 79077 =============================================================================== Complex CCSB-HI1-union-LCI.30 Size of complex: 6 Interactions within complex: 1398 5156 1398 5359 2771 5359 2771 51655 5155 5155 5155 5156 5359 51655 =============================================================================== Complex CCSB-HI1-union-LCI.49 Size of complex: 2 Interactions within complex: 3131 3131 3131 7008 7008 7008 =============================================================================== Complex CCSB-HI1-union-LCI.50 Size of complex: 2 Interactions within complex: 5747 5747 5747 7430 7430 7430 =============================================================================== Complex CCSB-HI1-union-LCI.52 Size of complex: 2 Interactions within complex: 3932 3932 3932 7070 7070 7070 =============================================================================== Complex CCSB-HI1-union-LCI.06 Size of complex: 4 Interactions within complex: 9802 9802 9802 23543 9802 54472 9802 84528 23543 84528 54472 84528 84528 84528 =============================================================================== Complex CCSB-HI1-union-LCI.44 Size of complex: 3 Interactions within complex: 8907 92610 8907 127557 92610 92610 127557 127557 =============================================================================== Complex CCSB-HI1-union-LCI.51 Size of complex: 2 Interactions within complex: 1649 1649 1649 51171 51171 51171 =============================================================================== Complex CCSB-HI1-union-LCI.21 Size of complex: 8 Interactions within complex: 3183 3183 3183 5300 3183 55285 3190 3190 3190 10179 3190 10656 3190 55285 3190 202559 5300 23062 10179 10656 10656 10656 10656 202559 23062 23062 =============================================================================== Complex CCSB-HI1-union-LCI.03 Size of complex: 8 Interactions within complex: 800 805 800 808 805 3785 805 4760 805 5475 805 5865 805 5899 808 3785 808 4760 808 5475 808 5865 808 5899 =============================================================================== Complex CCSB-HI1-union-LCI.43 Size of complex: 3 Interactions within complex: 10241 10241 10241 79797 55145 55145 55145 79797 79797 79797 =============================================================================== Complex CCSB-HI1-union-LCI.41 Size of complex: 4 Interactions within complex: 10733 10733 10733 23281 23281 55734 55734 57596 57596 57596 =============================================================================== Complex CCSB-HI1-union-LC.63 Size of complex: 8 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 6 0 6948 0.25 1 0.00029 0 3.7 1.2e-06 < 0.001 basolateral plasma membrane 2 6 0 6948 0.25 1 0.00029 0 3.7 1.2e-06 < 0.001 basal part of cell 2 6 0 6948 0.25 1 0.00029 0 3.7 1.2e-06 < 0.001 intermediate filament-based process 3 5 28 6920 0.38 0.097 0.0045 0.004 2.2 4.4e-06 < 0.001 apicolateral plasma membrane 2 6 3 6945 0.25 0.4 0.00072 0.00043 2.9 1.2e-05 0.005 cell-matrix junction 3 5 62 6886 0.38 0.046 0.0093 0.0089 1.8 4.2e-05 0.01 cell junction 3 5 177 6771 0.38 0.017 0.026 0.025 1.4 0.00087 0.097 cytoskeleton organization and biogenesis Interactions within complex: 320 320 320 3768 667 1639 667 55914 840 840 840 1639 1742 3768 1742 8825 1742 55914 3768 8825 55914 55914 =============================================================================== Complex CCSB-HI1-union-LC.08 Size of complex: 4 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 1 11 6941 0.75 0.21 0.002 0.0016 3.1 2.6e-08 < 0.001 transmembrane receptor protein serine/threonine kinase activity 3 1 32 6920 0.75 0.086 0.005 0.0046 2.7 4.7e-07 < 0.001 receptor signaling protein serine/threonine kinase activity/receptor signalling protein serine/threonine kinase activity 3 1 70 6882 0.75 0.041 0.01 0.01 2.4 4.4e-06 < 0.001 transmembrane receptor protein kinase activity 3 1 84 6868 0.75 0.034 0.013 0.012 2.3 7.5e-06 < 0.001 receptor signaling protein activity/receptor signalling protein activity 3 1 90 6862 0.75 0.032 0.013 0.013 2.2 9.2e-06 < 0.001 protein serine/threonine kinase activity 3 1 138 6814 0.75 0.021 0.02 0.02 2.1 3.2e-05 0.007 enzyme linked receptor protein signaling pathway/enzyme linked receptor protein signalling pathway 2 2 24 6928 0.5 0.077 0.0037 0.0035 2.5 8e-05 0.014 transmembrane receptor protein serine/threonine kinase signaling pathway/transmembrane receptor protein serine/threonine kinase signalling pathway 3 1 361 6591 0.75 0.0082 0.052 0.052 1.6 0.00055 0.05 protein kinase activity Interactions within complex: 652 652 652 657 652 658 652 659 657 657 657 658 657 659 658 658 658 659 659 659 =============================================================================== Complex CCSB-HI1-union-LC.38 Size of complex: 14 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 9 5 336 6606 0.64 0.026 0.05 0.048 1.5 2.6e-09 < 0.001 programmed cell death 9 5 345 6597 0.64 0.025 0.051 0.05 1.5 3.3e-09 < 0.001 cell death 9 5 352 6590 0.64 0.025 0.052 0.051 1.5 3.9e-09 < 0.001 death 6 8 225 6717 0.43 0.026 0.033 0.032 1.4 3e-06 0.001 apoptosis/type I programmed cell death 5 9 213 6729 0.36 0.023 0.031 0.031 1.3 4.6e-05 0.013 regulation of programmed cell death 6 8 379 6563 0.43 0.016 0.055 0.055 1.1 5.7e-05 0.016 positive regulation of biological process 5 9 324 6618 0.36 0.015 0.047 0.047 1.1 0.00032 0.062 positive regulation of cellular process 4 10 191 6751 0.29 0.021 0.028 0.028 1.2 0.00048 0.088 regulation of apoptosis Interactions within complex: 330 842 330 7186 842 842 842 3002 2081 2081 2081 7186 3002 3002 3604 7186 3604 8744 4049 4049 4049 4050 4049 4055 4050 4050 4050 4055 4055 4055 4055 7186 7186 7186 7186 7874 7186 8744 7186 10010 7186 10758 7186 92610 7874 7874 7874 10010 10758 10758 92610 92610 =============================================================================== Complex CCSB-HI1-union-LC.33 Size of complex: 14 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 11 3 976 5966 0.79 0.011 0.14 0.14 1.3 1.1e-07 < 0.001 regulation of transcription 11 3 989 5953 0.79 0.011 0.14 0.14 1.3 1.2e-07 < 0.001 transcription, DNA-dependent 11 3 1018 5924 0.79 0.011 0.15 0.15 1.3 1.7e-07 < 0.001 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 11 3 1032 5910 0.79 0.011 0.15 0.15 1.3 1.9e-07 < 0.001 transcription 11 3 1047 5895 0.79 0.01 0.15 0.15 1.3 2.2e-07 < 0.001 regulation of cellular metabolism 11 3 1134 5808 0.79 0.0096 0.16 0.16 1.2 5.2e-07 < 0.001 regulation of metabolism 12 2 1615 5327 0.86 0.0074 0.23 0.23 1.2 1.5e-06 < 0.001 regulation of cellular physiological process 12 2 1710 5232 0.86 0.007 0.25 0.25 1.2 2.8e-06 0.001 regulation of cellular process 12 2 1725 5217 0.86 0.0069 0.25 0.25 1.2 3.1e-06 0.001 regulation of physiological process 12 2 1893 5049 0.86 0.0063 0.27 0.27 1.1 8.8e-06 0.002 regulation of biological process/regulation 11 3 1586 5356 0.79 0.0069 0.23 0.23 1 1.6e-05 0.002 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 4 10 131 6811 0.29 0.03 0.019 0.019 1.3 0.00012 0.023 nucleoplasm 7 7 727 6215 0.5 0.0095 0.11 0.1 0.93 0.00025 0.04 transcription regulator activity 3 11 65 6877 0.21 0.044 0.0098 0.0094 1.5 0.0003 0.047 RNA polymerase II transcription factor activity 13 1 3189 3753 0.93 0.0041 0.46 0.46 1 0.00033 0.049 primary metabolism 13 1 3260 3682 0.93 0.004 0.47 0.47 1 0.00043 0.064 cellular metabolism 13 1 3338 3604 0.93 0.0039 0.48 0.48 0.99 0.00058 0.091 metabolism/metabolic process Interactions within complex: 602 2957 602 2959 602 4790 1163 1163 1163 6502 1869 4790 1869 5934 1869 6502 2932 2932 2932 4790 2932 4851 2957 2959 2957 2961 2959 2961 4790 4790 4790 4851 4790 23421 4851 4851 4851 51176 5934 7343 6502 6502 7343 51176 23421 23421 =============================================================================== Complex CCSB-HI1-union-LC.26 Size of complex: 211 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 112 99 1874 4871 0.53 0.056 0.29 0.28 0.47 2.6e-14 < 0.001 cell communication 27 184 157 6588 0.13 0.15 0.026 0.023 0.79 5.5e-12 < 0.001 G-protein coupled receptor protein signaling pathway/G-protein coupled receptor protein signalling pathway 49 162 525 6220 0.23 0.085 0.083 0.078 0.56 1.1e-11 < 0.001 cell surface receptor linked signal transduction 74 137 1088 5657 0.35 0.064 0.17 0.16 0.45 3.9e-11 < 0.001 signal transduction 22 189 126 6619 0.1 0.15 0.021 0.019 0.79 4.5e-10 < 0.001 rhodopsin-like receptor activity/Class A G-protein coupled receptor 23 188 164 6581 0.11 0.12 0.027 0.024 0.7 7.9e-09 < 0.001 G-protein coupled receptor activity/G-protein linked receptor/GPCR 73 138 1210 5535 0.35 0.057 0.18 0.18 0.39 1.1e-08 < 0.001 signal transducer activity 15 196 78 6667 0.071 0.16 0.013 0.012 0.83 9.9e-08 < 0.001 taxis 17 194 111 6634 0.081 0.13 0.018 0.016 0.73 2.6e-07 < 0.001 response to chemical substance 13 198 63 6682 0.062 0.17 0.011 0.0093 0.85 3.6e-07 < 0.001 peptide receptor activity, G-protein coupled 17 194 115 6630 0.081 0.13 0.019 0.017 0.71 4e-07 < 0.001 second-messenger-mediated signaling/second-messenger-mediated signalling 34 177 415 6330 0.16 0.076 0.065 0.062 0.47 5.1e-07 < 0.001 transmembrane receptor activity 13 198 67 6678 0.062 0.16 0.012 0.0099 0.83 6.7e-07 < 0.001 peptide receptor activity 29 182 337 6408 0.14 0.079 0.053 0.05 0.49 1.6e-06 < 0.001 neurophysiological process 61 150 1065 5680 0.29 0.054 0.16 0.16 0.34 1.7e-06 < 0.001 organismal physiological process 7 204 15 6730 0.033 0.32 0.0032 0.0022 1.2 2.5e-06 < 0.001 G-protein chemoattractant receptor activity 9 202 33 6712 0.043 0.21 0.006 0.0049 0.97 3.4e-06 0.001 chemokine receptor binding/chemokine receptor ligand 9 202 33 6712 0.043 0.21 0.006 0.0049 0.97 3.4e-06 0.001 G-protein-coupled receptor binding/G-protein-coupled receptor ligand 7 204 16 6729 0.033 0.3 0.0033 0.0024 1.2 3.5e-06 0.001 chemokine binding 49 162 811 5934 0.23 0.057 0.12 0.12 0.35 6.4e-06 0.001 plasma membrane/bacterial inner membrane/cell membrane/cytoplasmic membrane/juxtamembrane/plasmalemma 27 184 332 6413 0.13 0.075 0.052 0.049 0.46 9.8e-06 0.002 extracellular region/extracellular 33 178 460 6285 0.16 0.067 0.071 0.068 0.41 1.1e-05 0.002 intracellular signaling cascade/intracellular signalling cascade 28 183 357 6388 0.13 0.073 0.055 0.053 0.44 1.2e-05 0.003 cell fraction 20 191 205 6540 0.095 0.089 0.032 0.03 0.53 1.4e-05 0.003 response to abiotic stimulus 13 198 92 6653 0.062 0.12 0.015 0.014 0.69 1.5e-05 0.004 peptide binding 11 200 66 6679 0.052 0.14 0.011 0.0098 0.76 1.8e-05 0.004 cyclic-nucleotide-mediated signaling/cyclic-nucleotide-mediated signalling 36 175 541 6204 0.17 0.062 0.083 0.08 0.38 2.1e-05 0.006 receptor activity 13 198 96 6649 0.062 0.12 0.016 0.014 0.67 2.3e-05 0.006 cytokine activity 6 205 16 6729 0.028 0.27 0.0032 0.0024 1.1 3.6e-05 0.01 neuropeptide receptor activity 6 205 18 6727 0.028 0.25 0.0035 0.0027 1.1 6.2e-05 0.017 neuropeptide binding 185 26 5182 1563 0.88 0.034 0.77 0.77 0.32 6.2e-05 0.017 cellular process 25 186 333 6412 0.12 0.07 0.051 0.049 0.42 7.4e-05 0.018 receptor binding/receptor ligand 40 171 676 6069 0.19 0.056 0.1 0.1 0.33 8.6e-05 0.024 intrinsic to plasma membrane 9 202 54 6691 0.043 0.14 0.0091 0.008 0.76 0.0001 0.029 cytokine binding 156 55 4143 2602 0.74 0.036 0.62 0.61 0.25 0.00011 0.034 binding/ligand 5 206 12 6733 0.024 0.29 0.0024 0.0018 1.2 0.00011 0.037 chemokine receptor activity 18 193 216 6529 0.085 0.077 0.034 0.032 0.46 0.00025 0.078 detection of external stimulus/perception of external stimulus Interactions within complex: 89 89 89 135 100 134 100 135 108 111 108 2778 111 111 111 2770 111 2778 111 5997 134 2775 134 2911 135 1813 156 2492 156 5957 163 701 163 4292 207 2475 207 3858 207 5586 207 7248 207 7534 207 8600 339 10659 339 29974 369 2202 369 5604 407 8546 407 27232 701 8546 859 1605 859 2778 859 4842 960 972 960 5552 972 972 972 4282 999 999 999 8826 1081 1081 1081 1082 1081 2488 1081 3972 1081 3973 1082 2488 1082 3973 1191 1191 1191 3952 1191 3953 1191 7436 1191 7804 1234 6348 1234 6351 1234 6355 1234 6356 1234 6357 1234 6360 1237 6351 1237 6360 1238 6348 1238 6351 1238 6355 1238 6356 1238 6357 1295 3672 1295 83755 1305 1305 1305 3672 1308 1308 1308 5493 1325 6751 1325 6755 1437 1437 1437 1438 1437 1439 1437 4254 1438 1439 1439 1439 1439 7534 1468 22924 1468 83755 1482 2626 1482 6910 1600 3949 1600 5048 1600 7436 1600 7804 1605 1605 1605 7402 1813 1813 1813 3763 1813 3765 1813 6755 1901 2770 1901 3350 1901 3352 2078 2078 2078 2313 2125 3713 2125 3858 2125 5493 2125 6707 2202 6449 2313 2623 2323 2323 2323 4254 2475 2475 2475 10243 2488 2488 2488 2492 2492 2870 2532 2919 2532 3576 2623 23414 2626 4776 2626 6910 2626 23414 2770 5999 2770 6002 2770 10636 2770 51655 2775 5999 2775 10636 2778 3973 2778 5997 2869 5957 2869 6869 2870 5957 2872 2872 2872 5594 2911 2911 2911 9456 2919 2919 2919 3577 2919 3579 2920 2920 2920 3577 2920 3579 3118 3119 3118 3630 3119 3630 3184 6294 3184 54512 3350 3350 3350 3351 3350 3352 3351 3351 3351 3352 3352 3352 3572 5008 3572 9021 3572 9180 3576 3576 3576 3577 3576 3579 3576 6351 3579 3579 3579 6002 3630 3630 3630 94121 3672 3672 3672 4146 3672 284217 3713 6707 3763 3763 3763 3765 3949 9784 3952 3953 3953 8525 3953 9021 3972 3973 3984 3984 3984 7534 4146 4148 4146 8785 4148 4148 4148 8785 4218 9501 4218 94121 4224 4224 4224 4225 4224 284217 4225 4225 4225 5697 4254 4254 4254 9820 4282 4282 4292 4438 4292 23650 4292 27030 4438 27030 4773 4773 4773 7534 4776 7534 4832 4832 4832 6449 4842 51655 4867 4867 4867 9564 4887 4887 4887 5697 4887 6002 4905 4905 4905 11337 5008 9180 5048 5048 5048 6249 5116 10142 5116 10426 5241 7337 5241 51366 5394 6499 5394 23016 5552 6348 5552 6449 5576 6407 5576 9495 5576 10142 5586 10746 5594 5604 5594 5794 5594 6196 5594 6721 5594 8569 5594 8600 5594 8649 5594 51366 5604 6196 5604 8649 5794 9564 5868 8411 5868 9610 5869 8411 5869 9610 5997 22981 5998 7534 5998 10114 6002 6002 6249 8826 6294 8683 6337 6338 6337 23327 6338 23327 6348 6348 6348 6351 6351 6351 6403 6403 6403 9784 6406 6407 6406 7051 6407 7051 6449 6449 6449 6860 6499 6628 6499 54512 6628 8940 6645 7402 6645 8525 6721 6721 6750 6751 6750 6755 6751 6755 6860 6860 6860 10492 6863 6865 6863 6866 6863 6869 6863 6870 6865 6866 6866 6869 6866 6870 7163 7163 7163 7164 7163 114569 7164 7164 7164 7534 7164 114569 7248 7534 7324 7326 7324 7337 7324 23327 7326 7337 7332 7337 7332 23327 7337 7337 7337 9820 7402 7402 7436 9784 7534 7534 7534 9261 7534 9564 7534 9610 7534 10746 7791 9501 7791 10114 7804 9784 8411 8411 8411 23673 8569 8569 8683 8996 8826 9495 8940 83755 8996 8996 9261 9261 9454 9456 9454 140735 9456 23673 9564 10045 9820 23291 10045 10045 10142 10426 10243 10243 10243 11337 10243 140735 10492 29974 10659 29974 10982 10982 10982 22924 11337 11337 22981 84445 23016 23404 23016 54512 23291 23291 23404 54512 23650 23650 23650 84445 27232 27232 54512 54512 83755 83755 =============================================================================== Complex CCSB-HI1-union-LC.17 Size of complex: 10 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 10 0 1617 5329 1 0.0061 0.23 0.23 1.8 4.8e-07 < 0.001 regulation of cellular physiological process 10 0 1712 5234 1 0.0058 0.25 0.25 1.8 8.5e-07 < 0.001 regulation of cellular process 10 0 1727 5219 1 0.0058 0.25 0.25 1.8 9.2e-07 < 0.001 regulation of physiological process 10 0 1895 5051 1 0.0052 0.27 0.27 1.7 2.3e-06 < 0.001 regulation of biological process/regulation 8 2 1050 5896 0.8 0.0076 0.15 0.15 1.3 9.4e-06 < 0.001 regulation of cellular metabolism 8 2 1137 5809 0.8 0.007 0.16 0.16 1.2 1.7e-05 0.002 regulation of metabolism 7 3 980 5966 0.7 0.0071 0.14 0.14 1.1 9.2e-05 0.017 regulation of transcription 7 3 993 5953 0.7 0.007 0.14 0.14 1.1 0.0001 0.017 transcription, DNA-dependent 7 3 1022 5924 0.7 0.0068 0.15 0.15 1.1 0.00012 0.022 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 7 3 1036 5910 0.7 0.0067 0.15 0.15 1.1 0.00013 0.026 transcription 7 3 1356 5590 0.7 0.0051 0.2 0.2 0.95 0.00075 0.093 nucleic acid binding Interactions within complex: 2969 5396 2969 6722 2969 9063 3593 3594 3593 3595 3594 3595 3594 6775 3595 6775 5396 6722 6722 6722 6722 57591 6722 93649 6775 9063 57591 93649 =============================================================================== Complex CCSB-HI1-union-LC.46 Size of complex: 19 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 14 5 1656 5281 0.74 0.0084 0.24 0.24 0.92 6.7e-06 < 0.001 membrane 2 17 1 6936 0.11 0.67 0.00043 0.00014 2.8 2.1e-05 0.007 vasoconstriction/negative regulation of blood vessel size 2 17 3 6934 0.11 0.4 0.00072 0.00043 2.5 7e-05 0.024 regulation of blood vessel size 11 8 1272 5665 0.58 0.0086 0.18 0.18 0.78 0.00014 0.036 signal transducer activity 6 13 352 6585 0.32 0.017 0.051 0.051 0.95 0.00027 0.067 receptor binding/receptor ligand 11 8 1382 5555 0.58 0.0079 0.2 0.2 0.74 0.00031 0.07 intrinsic to membrane 2 17 8 6929 0.11 0.2 0.0014 0.0012 2.1 0.00031 0.076 cell fate commitment Interactions within complex: 133 1906 133 3075 133 4880 182 4242 182 4301 182 4853 1906 4880 1948 2051 1948 6386 1991 1991 1991 6382 2051 4301 2890 2893 2890 6386 2893 6386 3075 6402 4242 4853 4301 5819 4771 4771 4771 6386 4771 7430 5819 5819 6382 6386 6402 7430 7430 7430 =============================================================================== Complex CCSB-HI1-union-LC.13 Size of complex: 56 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 23 33 631 6269 0.41 0.035 0.094 0.091 0.84 2.7e-10 < 0.001 non-membrane-bound organelle 23 33 631 6269 0.41 0.035 0.094 0.091 0.84 2.7e-10 < 0.001 intracellular non-membrane-bound organelle 49 7 3359 3541 0.88 0.014 0.49 0.49 0.84 1.4e-09 < 0.001 intracellular/protoplasm 45 11 2845 4055 0.8 0.016 0.42 0.41 0.75 2.9e-09 < 0.001 intracellular organelle 45 11 2846 4054 0.8 0.016 0.42 0.41 0.75 2.9e-09 < 0.001 organelle 6 50 32 6868 0.11 0.16 0.0055 0.0046 1.4 4.7e-07 < 0.001 membrane coat 6 50 32 6868 0.11 0.16 0.0055 0.0046 1.4 4.7e-07 < 0.001 vesicle coat 6 50 32 6868 0.11 0.16 0.0055 0.0046 1.4 4.7e-07 < 0.001 coated membrane 7 49 63 6837 0.12 0.1 0.01 0.0091 1.2 1.2e-06 0.001 coated vesicle 8 48 111 6789 0.14 0.067 0.017 0.016 1 4.1e-06 0.001 endomembrane system 7 49 80 6820 0.12 0.08 0.013 0.012 1.1 5.3e-06 0.002 cytoplasmic vesicle 11 45 269 6631 0.2 0.039 0.04 0.039 0.79 1.1e-05 0.003 cytoskeleton 6 50 59 6841 0.11 0.092 0.0093 0.0086 1.2 1.2e-05 0.003 cell junction 3 53 4 6896 0.054 0.43 0.001 0.00058 2 1.7e-05 0.003 COPI-coated vesicle 13 43 402 6498 0.23 0.031 0.06 0.058 0.7 1.8e-05 0.003 nucleus 5 51 41 6859 0.089 0.11 0.0066 0.0059 1.2 3e-05 0.005 nuclear membrane/nuclear envelope 6 50 72 6828 0.11 0.077 0.011 0.01 1.1 3.4e-05 0.005 actin cytoskeleton 4 52 22 6878 0.071 0.15 0.0037 0.0032 1.4 4.9e-05 0.009 clathrin coat/clathrin cage 9 47 218 6682 0.16 0.04 0.033 0.032 0.79 7.1e-05 0.025 structural molecule activity 51 5 4745 2155 0.91 0.011 0.69 0.69 0.63 7.6e-05 0.025 cell 8 48 176 6724 0.14 0.043 0.026 0.026 0.82 9.9e-05 0.03 organelle membrane 6 50 93 6807 0.11 0.061 0.014 0.013 0.97 0.00013 0.038 mRNA processing 4 52 32 6868 0.071 0.11 0.0052 0.0046 1.3 0.00018 0.053 pore complex/pore 7 49 147 6753 0.12 0.045 0.022 0.021 0.84 0.00021 0.084 mRNA metabolism 10 46 314 6586 0.18 0.031 0.047 0.046 0.67 0.00022 0.086 establishment of protein localization/protein positioning/protein recruitment 10 46 318 6582 0.18 0.03 0.047 0.046 0.67 0.00024 0.089 protein localization Interactions within complex: 60 60 60 70 60 2010 60 4093 60 7170 60 8904 60 131034 70 1756 70 5581 70 7414 70 10097 331 331 331 836 372 1315 372 26958 836 836 836 1975 836 64689 890 983 890 5757 983 5757 983 64689 1104 1104 1104 5757 1104 7514 1104 8498 1211 1213 1211 9026 1212 1213 1212 9026 1213 1213 1213 7414 1213 9026 1315 5581 1315 6892 1315 26958 1756 1756 1823 1829 1823 5318 1824 1828 1824 1829 1824 5318 1828 5318 1829 5318 1975 1975 1975 26986 2010 4000 3191 3191 3191 5094 3939 3939 3939 7414 4000 4000 4093 5318 4928 4928 4928 23636 5094 5094 5094 26986 5094 55660 5108 9001 5108 10152 5757 23636 6607 6635 6607 6637 6607 11218 6626 6626 6626 7414 6635 6635 6635 6637 6635 7414 6635 11218 6637 7414 6637 11218 6892 26958 7170 7170 7414 7414 7414 10152 7414 26986 7414 51637 7414 55660 7514 8498 7514 23636 8904 8904 8904 131034 9001 9001 10093 10094 10093 10097 10093 10109 10094 10095 10094 10097 10094 10109 10095 10097 10095 10109 10097 10109 10109 10109 10152 54474 23636 23636 51637 51637 54474 54474 55660 55660 64689 64689 =============================================================================== Complex CCSB-HI1-union-LC.41 Size of complex: 7 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 4 1 6948 0.43 0.75 0.00058 0.00014 3.6 2.5e-09 < 0.001 UDP-glucosyltransferase activity 3 4 1 6948 0.43 0.75 0.00058 0.00014 3.6 2.5e-09 < 0.001 glucosyltransferase activity 3 4 2 6947 0.43 0.6 0.00072 0.00029 3.3 6.2e-09 < 0.001 glucan biosynthesis 3 4 3 6946 0.43 0.5 0.00086 0.00043 3.2 1.2e-08 < 0.001 polysaccharide biosynthesis/glycan biosynthesis 3 4 3 6946 0.43 0.5 0.00086 0.00043 3.2 1.2e-08 < 0.001 biopolymer biosynthesis 3 4 4 6945 0.43 0.43 0.001 0.00058 3.1 2.2e-08 < 0.001 glycogen metabolism 3 4 16 6933 0.43 0.16 0.0027 0.0023 2.5 6e-07 < 0.001 energy reserve metabolism 3 4 16 6933 0.43 0.16 0.0027 0.0023 2.5 6e-07 < 0.001 glucan metabolism 3 4 18 6931 0.43 0.14 0.003 0.0026 2.5 8.2e-07 < 0.001 cellular polysaccharide metabolism/cellular glycan metabolism 3 4 18 6931 0.43 0.14 0.003 0.0026 2.5 8.2e-07 < 0.001 polysaccharide metabolism/glycan metabolism 3 4 19 6930 0.43 0.14 0.0032 0.0027 2.4 9.5e-07 0.002 UDP-glycosyltransferase activity 3 4 23 6926 0.43 0.12 0.0037 0.0033 2.4 1.6e-06 0.002 carbohydrate biosynthesis/anabolic carbohydrate metabolism 3 4 27 6922 0.43 0.1 0.0043 0.0039 2.3 2.5e-06 0.002 transferase activity, transferring hexosyl groups/hexosyltransferase 3 4 45 6904 0.43 0.062 0.0069 0.0065 2.1 1.1e-05 0.003 transferase activity, transferring glycosyl groups/glycosyltransferase 3 4 73 6876 0.43 0.039 0.011 0.011 1.9 4.3e-05 0.012 energy derivation by oxidation of organic compounds/chemoorganotrophy 3 4 110 6839 0.43 0.027 0.016 0.016 1.7 0.00014 0.024 cellular carbohydrate metabolism 3 4 111 6838 0.43 0.026 0.016 0.016 1.7 0.00014 0.024 carbohydrate metabolism 3 4 186 6763 0.43 0.016 0.027 0.027 1.5 0.00064 0.081 generation of precursor metabolites and energy/energy pathways Interactions within complex: 2992 2997 2992 8908 2997 8550 2997 8908 4099 4155 4099 5354 4155 5354 4155 8550 =============================================================================== Complex CCSB-HI1-union-LC.18 Size of complex: 49 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 6 43 10 6897 0.12 0.38 0.0023 0.0014 2 6.8e-10 < 0.001 telomere maintenance 8 41 124 6783 0.16 0.061 0.019 0.018 1 3.2e-06 < 0.001 chromosome organization and biogenesis (sensu Eukaryota)/maintenance of genome integrity/nuclear genome maintenance 36 13 2854 4053 0.73 0.012 0.42 0.41 0.58 5.5e-06 0.001 intracellular organelle 36 13 2855 4052 0.73 0.012 0.42 0.41 0.58 5.6e-06 0.001 organelle 3 46 3 6904 0.061 0.5 0.00086 0.00043 2.2 6.5e-06 0.001 nucleotide-excision repair/interstrand crosslink repair/intrastrand cross-link repair 8 41 149 6758 0.16 0.051 0.023 0.022 0.97 1.2e-05 0.001 response to DNA damage stimulus 8 41 154 6753 0.16 0.049 0.023 0.022 0.95 1.5e-05 0.001 chromosome organization and biogenesis 25 24 1572 5335 0.51 0.016 0.23 0.23 0.55 1.6e-05 0.002 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 8 41 162 6745 0.16 0.047 0.024 0.023 0.93 2.1e-05 0.004 response to endogenous stimulus 37 12 3165 3742 0.76 0.012 0.46 0.46 0.55 2.4e-05 0.004 primary metabolism 11 38 349 6558 0.22 0.031 0.052 0.051 0.75 3e-05 0.004 DNA metabolism 7 42 124 6783 0.14 0.053 0.019 0.018 0.98 3.2e-05 0.004 chromosome 32 17 2493 4414 0.65 0.013 0.36 0.36 0.52 3.3e-05 0.004 intracellular membrane-bound organelle 32 17 2493 4414 0.65 0.013 0.36 0.36 0.52 3.3e-05 0.004 membrane-bound organelle 2 47 0 6907 0.041 1 0.00029 0 2.9 4.9e-05 0.02 chromosome, telomeric region/telomere 25 24 1712 5195 0.51 0.014 0.25 0.25 0.5 7.4e-05 0.026 regulation of physiological process 24 25 1603 5304 0.49 0.015 0.23 0.23 0.5 7.8e-05 0.026 regulation of cellular physiological process 37 12 3314 3593 0.76 0.011 0.48 0.48 0.51 8.4e-05 0.028 metabolism/metabolic process 17 32 896 6011 0.35 0.019 0.13 0.13 0.56 9.3e-05 0.032 biopolymer metabolism 5 44 62 6845 0.1 0.075 0.0096 0.009 1.1 9.8e-05 0.033 DNA repair 37 12 3371 3536 0.76 0.011 0.49 0.49 0.5 0.00013 0.04 intracellular/protoplasm 18 31 1025 5882 0.37 0.017 0.15 0.15 0.53 0.00014 0.041 transcription 24 25 1698 5209 0.49 0.014 0.25 0.25 0.47 0.0002 0.075 regulation of cellular process Interactions within complex: 286 7074 286 7273 286 84033 902 2071 902 8880 1263 9319 1263 10519 1488 1488 1488 2275 1488 8535 1488 11279 1488 60528 2068 2068 2068 2073 2068 2966 2071 2965 2071 2966 2071 5705 2073 2965 2247 2260 2247 9982 2260 2260 2260 2888 2275 2275 2275 7965 2275 11279 2275 222546 2888 80351 2965 8880 4077 9638 4077 10519 4683 7013 4683 7014 4830 4830 4830 4833 4830 6095 4830 7013 4830 7074 4833 4833 4833 9319 5702 5702 5702 5704 5702 5705 5704 5705 5705 6095 5989 5990 5989 5991 5990 5991 5990 5992 5990 222546 5991 5991 5991 5992 5991 222546 6015 6015 6015 8535 6015 60528 6095 6095 7013 7013 7013 8658 7013 25913 7013 80351 7014 7014 7273 84033 7273 84676 7965 7965 7965 8880 8658 25913 8658 80351 8658 85456 8975 84675 8975 84676 9319 9319 9638 10519 9982 9982 57159 84675 57159 84676 80351 85456 84675 84676 84676 84676 =============================================================================== Complex CCSB-HI1-union-LC.47 Size of complex: 10 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 4 6 32 6914 0.4 0.11 0.0052 0.0046 2.2 1.2e-07 < 0.001 stress-activated protein kinase signaling pathway/JNK signaling pathway/JNK signalling pathway/SAPK signaling pathway/SAPK signalling pathway/stress-activated protein kinase signalling pathway 4 6 61 6885 0.4 0.062 0.0093 0.0088 1.9 1.4e-06 0.001 MAPKKK cascade 2 8 2 6944 0.2 0.5 0.00058 0.00029 2.9 1.1e-05 0.004 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 4 6 164 6782 0.4 0.024 0.024 0.024 1.5 6.2e-05 0.012 protein kinase cascade 5 5 359 6587 0.5 0.014 0.052 0.052 1.3 7.7e-05 0.013 protein kinase activity 5 5 395 6551 0.5 0.013 0.058 0.057 1.2 0.00012 0.023 phosphorylation 5 5 418 6528 0.5 0.012 0.061 0.06 1.2 0.00016 0.031 phosphotransferase activity, alcohol group as acceptor 5 5 449 6497 0.5 0.011 0.065 0.065 1.2 0.00022 0.042 kinase activity/phosphokinase 2 8 16 6930 0.2 0.11 0.0026 0.0023 2.1 0.00028 0.044 JNK cascade/SAPK cascade/stress-activated protein kinase cascade 5 5 485 6461 0.5 0.01 0.07 0.07 1.1 0.00032 0.045 phosphate metabolism 5 5 488 6458 0.5 0.01 0.071 0.07 1.1 0.00033 0.046 intracellular signaling cascade/intracellular signalling cascade 5 5 491 6455 0.5 0.01 0.071 0.071 1.1 0.00034 0.046 phosphorus metabolism 5 5 539 6407 0.5 0.0092 0.078 0.078 1.1 0.00052 0.07 transferase activity, transferring phosphorus-containing groups Interactions within complex: 351 351 351 8650 351 9479 1400 1808 1400 6093 1808 6093 1808 8650 4296 5609 4296 7786 5609 7786 5609 9479 5609 51776 51776 51776 =============================================================================== Complex CCSB-HI1-union-LC.24 Size of complex: 51 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 11 40 146 6759 0.22 0.07 0.023 0.021 1.1 1.2e-08 < 0.001 response to DNA damage stimulus 11 40 159 6746 0.22 0.065 0.024 0.023 1.1 2.7e-08 < 0.001 response to endogenous stimulus 19 32 622 6283 0.37 0.03 0.092 0.09 0.78 4.7e-08 < 0.001 response to stress 4 47 10 6895 0.078 0.29 0.002 0.0014 1.8 2.4e-06 < 0.001 C-C chemokine binding 7 44 86 6819 0.14 0.075 0.013 0.012 1.1 4.4e-06 < 0.001 taxis 4 47 13 6892 0.078 0.24 0.0024 0.0019 1.7 5.7e-06 < 0.001 chemokine receptor activity 4 47 18 6887 0.078 0.18 0.0032 0.0026 1.5 1.7e-05 0.003 G-protein chemoattractant receptor activity 4 47 19 6886 0.078 0.17 0.0033 0.0028 1.5 2e-05 0.004 chemokine binding 21 30 1119 5786 0.41 0.018 0.16 0.16 0.56 2.1e-05 0.004 response to stimulus 7 44 121 6784 0.14 0.055 0.018 0.018 0.97 3.6e-05 0.009 response to chemical substance 3 48 8 6897 0.059 0.27 0.0016 0.0012 1.8 5.9e-05 0.024 condensed chromosome 4 47 31 6874 0.078 0.11 0.005 0.0045 1.3 0.00011 0.033 di-, tri-valent inorganic cation homeostasis 4 47 32 6873 0.078 0.11 0.0052 0.0046 1.3 0.00013 0.036 M phase of meiotic cell cycle 4 47 32 6873 0.078 0.11 0.0052 0.0046 1.3 0.00013 0.036 meiotic cell cycle 4 47 33 6872 0.078 0.11 0.0053 0.0048 1.3 0.00014 0.039 metal ion homeostasis 3 48 12 6893 0.059 0.2 0.0022 0.0017 1.6 0.00016 0.066 rhythmic process 3 48 13 6892 0.059 0.19 0.0023 0.0019 1.6 0.00019 0.073 maintenance of fidelity during DNA-dependent DNA replication 8 43 217 6688 0.16 0.036 0.032 0.031 0.78 0.0002 0.073 response to abiotic stimulus 10 41 350 6555 0.2 0.028 0.052 0.051 0.68 0.00023 0.076 DNA metabolism 4 47 38 6867 0.078 0.095 0.006 0.0055 1.2 0.00023 0.076 chemokine receptor binding/chemokine receptor ligand 4 47 38 6867 0.078 0.095 0.006 0.0055 1.2 0.00023 0.076 G-protein-coupled receptor binding/G-protein-coupled receptor ligand 3 48 14 6891 0.059 0.18 0.0024 0.002 1.5 0.00023 0.081 meiosis I 3 48 15 6890 0.059 0.17 0.0026 0.0022 1.5 0.00028 0.09 nuclear chromosome Interactions within complex: 374 896 374 4318 641 5888 641 8243 875 875 875 283987 896 1021 1021 1021 1021 5495 1230 6352 1230 6354 1231 6347 1231 6354 1232 6352 1232 6354 1398 2060 1398 11184 1407 1454 1407 5187 1407 8863 1407 8864 1407 8914 1454 5187 1454 8863 1454 25788 1618 1618 1618 23369 1999 2060 1999 9439 2060 2060 2060 9146 2139 6495 2139 11030 2826 6347 2826 6354 3934 3934 3934 4313 3934 4318 4313 4313 4313 6354 4313 6387 4313 7058 4318 4318 4318 7058 4436 4437 4436 8243 4436 9156 4437 9156 5037 5037 5037 6885 5187 8863 5187 8864 5187 8914 5495 6885 5608 5608 5608 6885 5888 11144 5888 25788 5888 283987 6347 6347 6352 6352 6354 6354 6387 6387 6495 6495 6885 9146 6885 11184 7058 7058 8697 11030 8697 25788 8863 8864 8864 8914 9146 57596 9402 11030 9402 11184 9439 23369 9883 10087 9883 11030 10087 10087 11030 11030 11144 25788 23369 23369 25788 25788 57596 57596 57596 283987 =============================================================================== Complex CCSB-HI1-union-LC.28 Size of complex: 4 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 4 0 248 6704 1 0.016 0.036 0.036 2.4 1.7e-06 < 0.001 RNA metabolism 3 1 78 6874 0.75 0.037 0.012 0.011 2.3 6e-06 0.002 RNA binding 2 2 23 6929 0.5 0.08 0.0036 0.0033 2.5 7.4e-05 0.013 mRNA transport 2 2 24 6928 0.5 0.077 0.0037 0.0035 2.5 8e-05 0.015 RNA-nucleus export 2 2 25 6927 0.5 0.074 0.0039 0.0036 2.4 8.7e-05 0.016 establishment of RNA localization/RNA positioning/RNA recruitment 2 2 25 6927 0.5 0.074 0.0039 0.0036 2.4 8.7e-05 0.016 nucleic acid transport 2 2 25 6927 0.5 0.074 0.0039 0.0036 2.4 8.7e-05 0.016 RNA transport 2 2 26 6926 0.5 0.071 0.004 0.0037 2.4 9.3e-05 0.016 RNA localization 2 2 26 6926 0.5 0.071 0.004 0.0037 2.4 9.3e-05 0.016 nucleobase, nucleoside, nucleotide and nucleic acid transport 2 2 27 6925 0.5 0.069 0.0042 0.0039 2.4 0.0001 0.016 nuclear export/export from nucleus/nucleus export/substance nuclear export 4 0 909 6043 1 0.0044 0.13 0.13 1.8 0.0003 0.029 biopolymer metabolism Interactions within complex: 3185 4686 3185 22916 3187 4686 3187 22916 4686 22916 =============================================================================== Complex CCSB-HI1-union-LC.09 Size of complex: 32 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 21 11 1576 5348 0.66 0.013 0.23 0.23 0.8 3e-07 < 0.001 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 7 25 150 6774 0.22 0.045 0.023 0.022 1.1 5.5e-06 < 0.001 response to DNA damage stimulus 27 5 3175 3749 0.84 0.0084 0.46 0.46 0.77 8.3e-06 < 0.001 primary metabolism 7 25 163 6761 0.22 0.041 0.024 0.024 1.1 9.2e-06 < 0.001 response to endogenous stimulus 12 20 607 6317 0.38 0.019 0.089 0.088 0.8 9.5e-06 < 0.001 DNA binding 27 5 3246 3678 0.84 0.0082 0.47 0.47 0.75 1.4e-05 0.001 cellular metabolism 27 5 3324 3600 0.84 0.0081 0.48 0.48 0.73 2.3e-05 0.008 metabolism/metabolic process 12 20 722 6202 0.38 0.016 0.11 0.1 0.72 5.3e-05 0.01 transcription regulator activity 8 24 352 6572 0.25 0.022 0.052 0.051 0.81 0.00017 0.04 DNA metabolism 13 19 1030 5894 0.41 0.012 0.15 0.15 0.6 0.00039 0.09 transcription Interactions within complex: 466 466 466 571 466 1390 466 1457 466 1459 571 1390 1390 1390 1457 1855 1457 2246 1457 6689 1457 9158 1459 2246 1855 1855 2175 2175 2175 2176 2175 2178 2175 2188 2175 2189 2176 2177 2176 2178 2176 2188 2176 2189 2176 3303 2177 2178 2178 2189 2188 2189 2189 2189 2246 2246 2246 9158 3303 7157 4205 4205 4205 4209 4205 5598 4205 7067 4209 4209 4209 5598 4692 4692 4692 7157 5595 6689 5595 7157 6689 6689 6996 7067 6996 7341 6996 7919 7132 7132 7132 7341 7155 7157 7155 7341 7157 7157 7157 7341 7157 8554 7157 9013 7157 9014 7157 9015 7341 7341 7341 8554 7919 7919 9013 9014 9013 9015 9014 9015 =============================================================================== Complex CCSB-HI1-union-LC.98 Size of complex: 2 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 0 1 6953 1 0.67 0.00043 0.00014 4.4 1.2e-07 < 0.001 diphosphotransferase activity 2 0 10 6944 1 0.17 0.0017 0.0014 3.5 2.7e-06 0.001 carbohydrate kinase activity 2 0 70 6884 1 0.028 0.01 0.01 2.7 0.00011 0.012 nucleotide metabolism Interactions within complex: 5631 5631 5631 5635 5635 5635 =============================================================================== Complex CCSB-HI1-union-LC.16 Size of complex: 41 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 11 30 61 6854 0.27 0.15 0.01 0.0088 1.6 1.6e-13 < 0.001 hemostasis 11 30 61 6854 0.27 0.15 0.01 0.0088 1.6 1.6e-13 < 0.001 wound healing 6 35 1 6914 0.15 0.86 0.001 0.00014 2.9 2e-13 < 0.001 sheet-forming collagen/network-forming collagen 11 30 63 6852 0.27 0.15 0.011 0.0091 1.6 2.2e-13 < 0.001 coagulation/clotting 8 33 16 6899 0.2 0.33 0.0035 0.0023 2 4.9e-13 < 0.001 collagen 11 30 76 6839 0.27 0.13 0.013 0.011 1.5 1.4e-12 < 0.001 regulation of body fluids 13 28 183 6732 0.32 0.066 0.028 0.026 1.2 4.2e-11 < 0.001 extracellular matrix 20 21 645 6270 0.49 0.03 0.096 0.093 0.97 1.2e-10 < 0.001 response to external stimulus 14 27 259 6656 0.34 0.051 0.039 0.037 1.1 2e-10 < 0.001 response to wounding 9 32 64 6851 0.22 0.12 0.01 0.0093 1.5 2.5e-10 < 0.001 inorganic anion transport 13 28 214 6701 0.32 0.057 0.033 0.031 1.2 2.7e-10 < 0.001 structural molecule activity 9 32 68 6847 0.22 0.12 0.011 0.0098 1.5 4.1e-10 < 0.001 anion transport 15 26 344 6571 0.37 0.042 0.052 0.05 1 6.8e-10 < 0.001 extracellular region/extracellular 6 35 19 6896 0.15 0.24 0.0036 0.0027 1.8 4.7e-09 < 0.001 basement membrane 9 32 107 6808 0.22 0.078 0.017 0.015 1.3 1.6e-08 < 0.001 extracellular matrix (sensu Metazoa) 17 24 624 6291 0.41 0.027 0.092 0.09 0.86 3.7e-08 < 0.001 response to stress 21 20 1105 5810 0.51 0.019 0.16 0.16 0.74 2.1e-07 < 0.001 organismal physiological process 21 20 1119 5796 0.51 0.018 0.16 0.16 0.73 2.6e-07 < 0.001 response to stimulus 10 31 242 6673 0.24 0.04 0.036 0.035 0.96 1.4e-06 < 0.001 ion transport 5 36 66 6849 0.12 0.07 0.01 0.0095 1.2 5.4e-05 0.015 serine-type peptidase activity/serine protease Interactions within complex: 259 259 259 2335 633 1277 633 1278 633 1284 1182 1182 1182 9368 1277 2335 1277 6678 1278 2335 1278 6678 1282 1282 1282 1284 1282 2199 1284 1284 1284 2199 1285 2199 1285 2335 1286 2199 1286 2335 1287 2199 1287 2335 1288 2199 1288 2335 2152 2152 2152 2155 2152 2159 2152 5340 2153 2153 2153 2159 2153 5627 2155 2155 2155 2159 2159 2159 2159 5327 2159 5340 2159 5627 2162 2162 2162 2266 2162 2335 2192 2192 2192 2244 2192 2335 2199 2199 2199 2335 2244 2266 2266 2266 2266 3383 2268 6504 2268 7454 2335 2934 2335 5310 2934 7408 3383 3383 3383 3683 3383 4478 3683 3683 4068 4068 4068 6504 4478 4478 4478 7412 4478 9368 5216 5216 5216 7408 5216 23214 5310 5311 5311 5311 5327 5327 5327 6678 5340 5340 5340 6678 6361 6361 6361 7412 6504 6504 6678 6678 7408 7408 7408 7454 7408 23214 7412 7412 =============================================================================== Complex CCSB-HI1-union-LC.70 Size of complex: 4 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 1 84 6868 0.75 0.034 0.013 0.012 2.3 7.5e-06 < 0.001 receptor signaling protein activity/receptor signalling protein activity 2 2 33 6919 0.5 0.057 0.005 0.0047 2.3 0.00015 0.026 receptor signaling protein serine/threonine kinase activity/receptor signalling protein serine/threonine kinase activity 2 2 34 6918 0.5 0.056 0.0052 0.0049 2.3 0.00016 0.027 stress-activated protein kinase signaling pathway/JNK signaling pathway/JNK signalling pathway/SAPK signaling pathway/SAPK signalling pathway/stress-activated protein kinase signalling pathway 2 2 63 6889 0.5 0.031 0.0093 0.0091 2 0.00051 0.056 MAPKKK cascade 3 1 361 6591 0.75 0.0082 0.052 0.052 1.6 0.00055 0.058 protein kinase activity Interactions within complex: 4216 5603 4216 5606 5603 23542 5606 23542 =============================================================================== Complex CCSB-HI1-union-LC.21 Size of complex: 11 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 5 6 55 6890 0.45 0.083 0.0086 0.0079 2 1.8e-08 < 0.001 hexose metabolism 5 6 55 6890 0.45 0.083 0.0086 0.0079 2 1.8e-08 < 0.001 monosaccharide metabolism 5 6 101 6844 0.45 0.047 0.015 0.015 1.8 3.2e-07 < 0.001 alcohol metabolism 5 6 108 6837 0.45 0.044 0.016 0.016 1.7 4.4e-07 < 0.001 cellular carbohydrate metabolism 5 6 109 6836 0.45 0.044 0.016 0.016 1.7 4.6e-07 < 0.001 carbohydrate metabolism 2 9 0 6945 0.18 1 0.00029 0 3.6 2.3e-06 < 0.001 pyruvate dehydrogenase complex/pyruvate dehydrogenase complex (lipoamide) 2 9 1 6944 0.18 0.67 0.00043 0.00014 3.1 6.8e-06 0.002 pyruvate dehydrogenase activity 11 0 2514 4431 1 0.0044 0.36 0.36 1.6 1.4e-05 0.003 intracellular membrane-bound organelle 11 0 2514 4431 1 0.0044 0.36 0.36 1.6 1.4e-05 0.003 membrane-bound organelle 3 8 31 6914 0.27 0.088 0.0049 0.0045 2 1.7e-05 0.003 glucose catabolism 3 8 33 6912 0.27 0.083 0.0052 0.0048 1.9 2e-05 0.004 monosaccharide catabolism 3 8 33 6912 0.27 0.083 0.0052 0.0048 1.9 2e-05 0.004 hexose catabolism 3 8 34 6911 0.27 0.081 0.0053 0.0049 1.9 2.2e-05 0.004 alcohol catabolism 3 8 39 6906 0.27 0.071 0.006 0.0056 1.9 3.3e-05 0.006 glucose metabolism 2 9 4 6941 0.18 0.33 0.00086 0.00058 2.6 3.4e-05 0.008 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor/oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor 3 8 40 6905 0.27 0.07 0.0062 0.0058 1.8 3.5e-05 0.008 cellular carbohydrate catabolism 3 8 40 6905 0.27 0.07 0.0062 0.0058 1.8 3.5e-05 0.008 carbohydrate catabolism/catabolic carbohydrate metabolism 3 8 42 6903 0.27 0.067 0.0065 0.006 1.8 4e-05 0.008 coenzyme metabolism 3 8 47 6898 0.27 0.06 0.0072 0.0068 1.8 5.5e-05 0.009 main pathways of carbohydrate metabolism 11 0 2879 4066 1 0.0038 0.42 0.41 1.5 6.3e-05 0.009 intracellular organelle 11 0 2880 4065 1 0.0038 0.42 0.41 1.5 6.3e-05 0.009 organelle 3 8 55 6890 0.27 0.052 0.0083 0.0079 1.7 8.7e-05 0.014 cofactor metabolism 2 9 8 6937 0.18 0.2 0.0014 0.0012 2.3 0.0001 0.017 mitochondrial matrix/mitochondrial stroma 2 9 10 6935 0.18 0.17 0.0017 0.0014 2.2 0.00015 0.02 acetyl-CoA metabolism 2 9 10 6935 0.18 0.17 0.0017 0.0014 2.2 0.00015 0.02 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3 8 73 6872 0.27 0.039 0.011 0.011 1.6 0.00019 0.024 energy derivation by oxidation of organic compounds/chemoorganotrophy 11 0 3397 3548 1 0.0032 0.49 0.49 1.4 0.00039 0.052 intracellular/protoplasm 3 8 101 6844 0.27 0.029 0.015 0.015 1.4 0.00049 0.059 establishment and/or maintenance of chromatin architecture 3 8 112 6833 0.27 0.026 0.017 0.016 1.4 0.00066 0.082 DNA packaging Interactions within complex: 86 2130 86 9031 1737 5160 1737 5162 1737 5163 1737 5164 1737 8050 2130 8050 5160 5160 5160 5162 5162 5162 5162 8050 5163 5164 5164 8050 9031 10036 10036 10951 10951 10951 =============================================================================== Complex CCSB-HI1-union-LC.69 Size of complex: 5 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 3 0 6951 0.4 1 0.00029 0 4 4.1e-07 < 0.001 interleukin-10 binding/IL-10 binding 2 3 17 6934 0.4 0.11 0.0027 0.0024 2.5 7e-05 0.009 B-cell activation 2 3 18 6933 0.4 0.1 0.0029 0.0026 2.4 7.8e-05 0.011 lymphocyte proliferation 2 3 21 6930 0.4 0.087 0.0033 0.003 2.4 0.0001 0.013 interleukin receptor activity/IL receptor 4 1 547 6404 0.8 0.0073 0.079 0.079 1.5 0.00018 0.016 defense response/defence response 2 3 29 6922 0.4 0.065 0.0045 0.0042 2.2 0.00019 0.016 interleukin binding/IL binding 2 3 37 6914 0.4 0.051 0.0056 0.0053 2.1 0.0003 0.019 growth factor binding 2 3 38 6913 0.4 0.05 0.0058 0.0055 2.1 0.00032 0.021 hematopoietin/interferon-class (D200-domain) cytokine receptor activity 4 1 655 6296 0.8 0.0061 0.095 0.094 1.5 0.00037 0.027 response to biotic stimulus 3 2 270 6681 0.6 0.011 0.039 0.039 1.5 0.00056 0.042 response to wounding Interactions within complex: 959 959 959 3500 3500 3500 3500 3586 3586 3586 3586 3587 3586 3588 3587 3588 =============================================================================== Complex CCSB-HI1-union-LC.23 Size of complex: 168 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 16 152 43 6745 0.095 0.27 0.0085 0.0063 1.2 2.9e-13 < 0.001 translation factor activity, nucleic acid binding 16 152 46 6742 0.095 0.26 0.0089 0.0068 1.2 6.8e-13 < 0.001 translation regulator activity 15 153 81 6707 0.089 0.16 0.014 0.012 0.92 7.1e-09 < 0.001 translation/protein translation 7 161 15 6773 0.042 0.32 0.0032 0.0022 1.3 5.3e-07 < 0.001 hormone activity 17 151 155 6633 0.1 0.099 0.025 0.023 0.69 7.1e-07 < 0.001 guanyl nucleotide binding 7 161 16 6772 0.042 0.3 0.0033 0.0024 1.3 7.5e-07 < 0.001 translational initiation/protein synthesis initiation 6 162 13 6775 0.036 0.32 0.0027 0.0019 1.3 3.8e-06 < 0.001 eukaryotic 43S preinitiation complex/eukaryotic 43S pre-initiation complex 7 161 22 6766 0.042 0.24 0.0042 0.0032 1.1 4.2e-06 < 0.001 regulation of translation 15 153 147 6641 0.089 0.093 0.023 0.022 0.66 7.4e-06 0.002 protein biosynthesis 16 152 168 6620 0.095 0.087 0.026 0.025 0.63 8.2e-06 0.002 G-protein coupled receptor protein signaling pathway/G-protein coupled receptor protein signalling pathway 16 152 171 6617 0.095 0.086 0.027 0.025 0.62 1e-05 0.003 G-protein coupled receptor activity/G-protein linked receptor/GPCR 151 17 5216 1572 0.9 0.028 0.77 0.77 0.42 1.3e-05 0.005 cellular process 10 158 67 6721 0.06 0.13 0.011 0.0099 0.82 1.4e-05 0.01 cyclic-nucleotide-mediated signaling/cyclic-nucleotide-mediated signalling 10 158 70 6718 0.06 0.12 0.012 0.01 0.8 2e-05 0.013 peptide receptor activity 18 150 240 6548 0.11 0.07 0.037 0.035 0.52 4.5e-05 0.023 macromolecule biosynthesis 13 155 135 6653 0.077 0.088 0.021 0.02 0.63 5.4e-05 0.025 rhodopsin-like receptor activity/Class A G-protein coupled receptor 3 165 2 6786 0.018 0.6 0.00072 0.00029 1.8 0.00013 0.055 response to hormone stimulus/growth regulator 6 162 29 6759 0.036 0.17 0.005 0.0043 0.96 0.00016 0.059 spindle 10 158 95 6693 0.06 0.095 0.015 0.014 0.67 0.00021 0.072 peptide binding 10 158 97 6691 0.06 0.093 0.015 0.014 0.66 0.00024 0.08 microtubule cytoskeleton 41 127 948 5840 0.24 0.041 0.14 0.14 0.3 0.00026 0.092 cytoplasm 9 159 81 6707 0.054 0.1 0.013 0.012 0.69 0.0003 0.099 regulation of biosynthesis 15 153 208 6580 0.089 0.067 0.032 0.031 0.5 0.0003 0.1 nucleoside-triphosphatase activity/nucleoside triphosphatase activity Interactions within complex: 116 6344 116 6469 181 4159 181 4160 181 4161 181 51738 375 375 375 8394 375 8943 375 9266 375 11316 375 22820 382 408 382 409 382 8394 382 8943 382 9266 400 2800 400 2803 408 4792 408 5144 408 5900 408 7201 408 9266 409 554 409 5021 409 5144 409 5900 409 7200 409 9266 432 433 432 7184 432 29956 433 29956 434 4157 434 4158 434 4159 434 4160 551 554 551 5021 636 5870 636 10540 823 826 823 831 823 4792 826 831 1159 1159 1159 7416 1627 9455 1627 23268 1810 10589 1810 54107 1814 2036 1814 23413 1816 2781 1816 23413 1964 1983 1964 8663 1965 8892 1965 23645 1967 8892 1967 8894 1983 8666 1983 8894 2036 4926 2036 116986 2324 7424 2324 55729 2512 2512 2512 51678 2781 8601 2800 5870 2803 23499 2806 3312 2806 4191 2861 5071 2861 10273 3206 3206 3206 4211 3206 5087 3233 4211 3233 5087 3238 4211 3238 23764 3312 3337 3312 10273 3313 4597 3313 7184 3313 7416 3337 10273 3434 3437 3434 3646 3437 3437 3549 5727 3549 8643 3646 51386 3855 8661 3855 55729 4157 4160 4157 5443 4158 5443 4160 4852 4160 5443 4161 5443 4191 4191 4261 4801 4261 5993 4261 8625 4597 4597 4599 4599 4599 7280 4605 4605 4605 7314 4628 5087 4628 57473 4751 4751 4751 5504 4751 11190 4792 7278 4792 10477 4792 23085 4801 10589 4852 5540 4852 51738 4878 4881 4878 4883 4879 4881 4879 4883 4881 55729 4883 4883 4926 5885 4926 8089 4926 10121 5071 5414 5071 7314 5071 9246 5071 9627 5144 5144 5144 9659 5347 5689 5347 7280 5347 7283 5347 9493 5414 9627 5422 23649 5422 92797 5450 6478 5450 6580 5504 84687 5540 23645 5540 84687 5689 167227 5727 6469 5727 6608 5727 50846 5870 10112 5870 23299 5885 8467 5993 5994 5993 8625 5994 8625 6343 6344 6343 7433 6469 6469 6469 8643 6478 9246 6580 29956 6608 8643 6760 6760 6760 8028 6867 8089 6867 9212 7200 7201 7201 7201 7224 7224 7224 11075 7278 7283 7283 25897 7283 29127 7314 9627 7424 7424 7433 8976 8028 8089 8467 54108 8601 11075 8643 50846 8661 8666 8661 8669 8661 27335 8663 8666 8663 8669 8664 8666 8664 8669 8664 51386 8666 51678 8890 8890 8890 8891 8890 8892 8890 8893 8890 8894 8891 8892 8891 8893 8892 8893 8893 8894 8976 23268 8976 23433 9025 10477 9025 80817 9212 29127 9246 25897 9455 116986 9493 29127 9659 57473 10112 51560 10121 10121 10540 23299 10589 54107 11190 55729 11316 22820 22820 23433 23085 51560 23499 55729 23645 57473 23649 92797 23649 167227 23764 23764 27335 51386 54107 54108 55729 60676 57473 60676 80817 220082 220082 220082 =============================================================================== Complex CCSB-HI1-union-LC.04 Size of complex: 6 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 5 1 27 6923 0.83 0.16 0.0046 0.0039 3 8.9e-12 < 0.001 complement activation 5 1 82 6868 0.83 0.057 0.013 0.012 2.5 1.6e-09 < 0.001 humoral defense mechanism (sensu Vertebrata)/acquired immune response/adaptive immune response/antibody-mediated immune response/humoral defence mechanism (sensu Vertebrata) 5 1 101 6849 0.83 0.047 0.015 0.015 2.4 4.4e-09 < 0.001 humoral immune response 6 0 333 6617 1 0.018 0.049 0.048 2.4 1.3e-08 < 0.001 response to pest, pathogen or parasite/response to pest/pathogen/parasite 6 0 350 6600 1 0.017 0.051 0.05 2.4 1.7e-08 < 0.001 response to external biotic stimulus 6 0 368 6582 1 0.016 0.054 0.053 2.4 2.3e-08 < 0.001 immune response 6 0 545 6405 1 0.011 0.079 0.078 2.2 2.4e-07 < 0.001 defense response/defence response 6 0 635 6315 1 0.0094 0.092 0.091 2.1 6e-07 < 0.001 response to stress 6 0 653 6297 1 0.0091 0.095 0.094 2.1 7.1e-07 < 0.001 response to biotic stimulus 6 0 659 6291 1 0.009 0.096 0.095 2.1 7.5e-07 < 0.001 response to external stimulus 2 4 6 6944 0.33 0.25 0.0012 0.00086 2.8 1.7e-05 0.002 extracellular space/intercellular space 6 0 1120 5830 1 0.0053 0.16 0.16 1.8 1.8e-05 0.002 organismal physiological process 6 0 1134 5816 1 0.0053 0.16 0.16 1.8 1.9e-05 0.002 response to stimulus 3 3 70 6880 0.5 0.041 0.01 0.01 2 2.2e-05 0.002 inorganic anion transport 3 3 74 6876 0.5 0.039 0.011 0.011 2 2.5e-05 0.005 anion transport Interactions within complex: 712 713 712 714 712 715 712 716 712 5806 713 714 713 715 713 5806 714 5806 715 715 715 716 716 716 =============================================================================== Complex CCSB-HI1-union-LC.35 Size of complex: 5 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 5 0 209 6742 1 0.023 0.031 0.03 2.5 2.6e-08 < 0.001 transcription from RNA polymerase II promoter/transcription from Pol II promoter 4 1 131 6820 0.8 0.03 0.019 0.019 2.2 6.7e-07 0.002 nucleoplasm 4 1 213 6738 0.8 0.018 0.031 0.031 2 4.5e-06 0.002 transcription factor binding/TF binding 4 1 234 6717 0.8 0.017 0.034 0.034 1.9 6.5e-06 0.002 regulation of transcription, DNA-dependent 5 0 729 6222 1 0.0068 0.11 0.1 2 1.3e-05 0.003 transcription regulator activity 5 0 982 5969 1 0.0051 0.14 0.14 1.8 5.7e-05 0.005 regulation of transcription 4 1 411 6540 0.8 0.0096 0.06 0.059 1.7 6e-05 0.005 nucleus 5 0 995 5956 1 0.005 0.14 0.14 1.8 6.1e-05 0.005 transcription, DNA-dependent 4 1 426 6525 0.8 0.0093 0.062 0.061 1.7 6.9e-05 0.007 cell cycle/cell-division cycle 5 0 1024 5927 1 0.0049 0.15 0.15 1.8 7e-05 0.007 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 5 0 1038 5913 1 0.0048 0.15 0.15 1.8 7.5e-05 0.007 transcription 5 0 1053 5898 1 0.0047 0.15 0.15 1.8 8.1e-05 0.008 regulation of cellular metabolism 5 0 1140 5811 1 0.0044 0.16 0.16 1.7 0.00012 0.011 regulation of metabolism 3 2 187 6764 0.6 0.016 0.027 0.027 1.7 0.00019 0.015 transcription cofactor activity/transcriptional co-regulator 4 1 615 6336 0.8 0.0065 0.089 0.088 1.5 0.00029 0.023 DNA binding 5 0 1592 5359 1 0.0031 0.23 0.23 1.6 0.00063 0.054 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 2 3 55 6896 0.4 0.035 0.0082 0.0079 1.9 0.00065 0.057 negative regulation of transcription, DNA-dependent 5 0 1622 5329 1 0.0031 0.23 0.23 1.6 0.0007 0.06 regulation of cellular physiological process Interactions within complex: 1871 7027 1871 7029 1871 23429 1876 7027 1876 7029 1876 23429 =============================================================================== Complex CCSB-HI1-union-LC.62 Size of complex: 14 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 11 3 6939 0.21 0.5 0.00086 0.00043 2.8 1.3e-07 < 0.001 amyloid precursor protein metabolism/APP metabolism 3 11 4 6938 0.21 0.43 0.001 0.00058 2.7 2.3e-07 < 0.001 glycoprotein catabolism/glycoprotein degradation 3 11 4 6938 0.21 0.43 0.001 0.00058 2.7 2.3e-07 < 0.001 beta-amyloid metabolism 3 11 5 6937 0.21 0.38 0.0012 0.00072 2.6 3.6e-07 < 0.001 Notch signaling pathway/N signaling pathway/N signalling pathway/Notch signalling pathway 11 3 1151 5791 0.79 0.0095 0.17 0.17 1.2 6e-07 < 0.001 signal transduction 12 2 1974 4968 0.86 0.006 0.29 0.28 1.1 1.4e-05 0.005 cell communication 3 11 33 6909 0.21 0.083 0.0052 0.0048 1.8 4.5e-05 0.015 glycoprotein metabolism 7 7 567 6375 0.5 0.012 0.083 0.082 1.1 5.2e-05 0.015 cell surface receptor linked signal transduction 7 7 802 6140 0.5 0.0087 0.12 0.12 0.88 0.00046 0.086 protein modification Interactions within complex: 27 613 27 2048 613 613 613 8440 1796 8440 1796 9448 2048 2048 2317 2811 2317 3688 2317 5664 2811 2811 3688 9448 4956 4956 4956 7205 5664 51107 5664 55851 7205 8440 51107 55851 =============================================================================== Complex CCSB-HI1-union-LC.10 Size of complex: 41 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 7 34 17 6898 0.17 0.29 0.0035 0.0025 1.9 4.6e-11 < 0.001 antigen presentation 6 35 17 6898 0.15 0.26 0.0033 0.0025 1.9 2.7e-09 < 0.001 antigen processing 7 34 39 6876 0.17 0.15 0.0066 0.0056 1.6 6.5e-09 < 0.001 ligand-dependent nuclear receptor activity/nuclear hormone receptor 4 37 8 6907 0.098 0.33 0.0017 0.0012 2 5e-07 < 0.001 detection of biotic stimulus/perception of biotic stimulus 11 30 363 6552 0.27 0.029 0.054 0.052 0.83 6.9e-06 0.001 immune response 20 21 1263 5652 0.49 0.016 0.18 0.18 0.63 9.2e-06 0.001 signal transducer activity 13 28 538 6377 0.32 0.024 0.079 0.078 0.75 9.3e-06 0.001 defense response/defence response 13 28 564 6351 0.32 0.023 0.083 0.082 0.73 1.5e-05 0.002 receptor activity 3 38 8 6907 0.073 0.27 0.0016 0.0012 1.9 3e-05 0.005 DNA alkylation 13 28 646 6269 0.32 0.02 0.095 0.093 0.66 6.3e-05 0.016 response to biotic stimulus 3 38 11 6904 0.073 0.21 0.002 0.0016 1.7 6.6e-05 0.018 DNA modification 2 39 1 6914 0.049 0.67 0.00043 0.00014 2.5 0.0001 0.037 DNA-methyltransferase activity 2 39 1 6914 0.049 0.67 0.00043 0.00014 2.5 0.0001 0.037 retinoic acid receptor activity/vitamin A receptor activity 7 34 183 6732 0.17 0.037 0.027 0.026 0.9 0.0001 0.037 transcription cofactor activity/transcriptional co-regulator 9 32 347 6568 0.22 0.025 0.051 0.05 0.74 0.00018 0.048 response to external biotic stimulus 7 34 210 6705 0.17 0.032 0.031 0.03 0.84 0.00024 0.067 transcription factor binding/TF binding 15 26 972 5943 0.37 0.015 0.14 0.14 0.55 0.00029 0.078 regulation of transcription 2 39 3 6912 0.049 0.4 0.00072 0.00043 2.1 0.00034 0.099 nuclear chromatin 2 39 3 6912 0.049 0.4 0.00072 0.00043 2.1 0.00034 0.099 heterochromatin 15 26 985 5930 0.37 0.015 0.14 0.14 0.55 0.00034 0.099 transcription, DNA-dependent Interactions within complex: 567 912 567 3135 811 912 811 3675 811 4153 967 3109 967 3122 967 3732 1475 1475 1475 1514 1476 1509 1476 1514 1509 1509 1511 3827 1511 5473 1514 1514 1514 3827 1514 6256 1788 1789 1788 29947 1789 23468 1789 29947 3015 3015 3015 3619 3108 3109 3108 3122 3108 3123 3108 3732 3109 3122 3109 3732 3122 3123 3122 3732 3123 3123 3135 3135 3619 23468 3675 3732 3827 22918 4153 4153 4153 22918 4929 6256 4929 6257 5473 5473 6256 6256 6256 7376 6256 8431 6256 8805 6256 8856 6256 9970 6257 6257 6257 7376 6257 8431 6257 8856 6921 6923 6921 7428 6921 23032 6923 7428 6923 23032 7376 7376 7376 8431 7428 10168 7428 23032 7556 8805 7556 10155 8431 9970 8805 8805 8805 10155 8805 23468 8856 8856 10155 10155 10155 10168 10155 23468 10168 10168 =============================================================================== Complex CCSB-HI1-union-LC.37 Size of complex: 19 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 5 14 21 6916 0.26 0.19 0.0037 0.003 2.1 5.4e-09 < 0.001 transmembrane receptor protein serine/threonine kinase signaling pathway/transmembrane receptor protein serine/threonine kinase signalling pathway 7 12 134 6803 0.37 0.05 0.02 0.019 1.5 5e-08 < 0.001 enzyme linked receptor protein signaling pathway/enzyme linked receptor protein signalling pathway 4 15 31 6906 0.21 0.11 0.005 0.0045 1.8 2e-06 < 0.001 receptor signaling protein serine/threonine kinase activity/receptor signalling protein serine/threonine kinase activity 5 14 82 6855 0.26 0.057 0.013 0.012 1.5 2.8e-06 < 0.001 receptor signaling protein activity/receptor signalling protein activity 3 16 11 6926 0.16 0.21 0.002 0.0016 2.1 6.2e-06 < 0.001 transmembrane receptor protein serine/threonine kinase activity 2 17 0 6937 0.11 1 0.00029 0 3.3 7.1e-06 0.003 transforming growth factor beta receptor activity/TGF-beta receptor activity/TGFbeta receptor activity/TGFbetaR 4 15 89 6848 0.21 0.043 0.013 0.013 1.3 1e-04 0.037 protein serine/threonine kinase activity 3 16 33 6904 0.16 0.083 0.0052 0.0048 1.6 0.00012 0.043 stress-activated protein kinase signaling pathway/JNK signaling pathway/JNK signalling pathway/SAPK signaling pathway/SAPK signalling pathway/stress-activated protein kinase signalling pathway 3 16 37 6900 0.16 0.075 0.0058 0.0053 1.6 0.00016 0.056 induction of apoptosis/apoptosis signaling/positive regulation of apoptosis 2 17 6 6931 0.11 0.25 0.0012 0.00086 2.2 0.0002 0.069 transforming growth factor beta receptor signaling pathway/TGF-beta receptor signaling pathway/TGF-beta receptor signalling pathway/TGFbeta receptor signaling pathway/TGFbeta receptor signalling pathway/transforming growth factor beta receptor signalling pathway Interactions within complex: 90 4086 90 4090 1173 1493 1173 1601 1493 1493 1601 7046 1601 7048 1616 7048 1616 28996 3667 3667 3667 5599 4086 4086 4086 4090 4086 28996 4090 6421 4609 5599 4609 7161 5725 5725 5725 6421 6421 7150 7043 7046 7043 7048 7043 7049 7046 7046 7046 7049 7048 7048 7048 7049 7150 7150 7161 7161 7161 28996 =============================================================================== Complex CCSB-HI1-union-LC.14 Size of complex: 26 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 9 17 24 6906 0.35 0.27 0.0047 0.0035 2.2 1.1e-15 < 0.001 microbody 6 20 8 6922 0.23 0.43 0.002 0.0012 2.4 4.3e-12 < 0.001 peroxisome/peroxisome vesicle 24 2 2501 4429 0.92 0.0095 0.36 0.36 1.2 3.5e-09 < 0.001 intracellular membrane-bound organelle 24 2 2501 4429 0.92 0.0095 0.36 0.36 1.2 3.5e-09 < 0.001 membrane-bound organelle 4 22 7 6923 0.15 0.36 0.0016 0.001 2.3 5e-08 < 0.001 peroxisomal membrane 4 22 7 6923 0.15 0.36 0.0016 0.001 2.3 5e-08 < 0.001 intrinsic to peroxisomal membrane 24 2 2866 4064 0.92 0.0083 0.42 0.41 1.1 7.8e-08 < 0.001 intracellular organelle 24 2 2867 4063 0.92 0.0083 0.42 0.41 1.1 7.9e-08 < 0.001 organelle 24 2 3384 3546 0.92 0.007 0.49 0.49 1 3.2e-06 0.003 intracellular/protoplasm 4 22 25 6905 0.15 0.14 0.0042 0.0036 1.7 3.4e-06 0.004 integral to organelle membrane 4 22 25 6905 0.15 0.14 0.0042 0.0036 1.7 3.4e-06 0.004 intrinsic to organelle membrane 7 19 177 6753 0.27 0.038 0.026 0.026 1.2 3.5e-06 0.004 organelle membrane 12 14 722 6208 0.46 0.016 0.11 0.1 0.87 4.2e-06 0.005 transcription regulator activity 3 23 7 6923 0.12 0.3 0.0014 0.001 2.1 5.5e-06 0.008 deacetylase activity 2 24 0 6930 0.077 1 0.00029 0 3.2 1.3e-05 0.012 peroxisome targeting sequence binding/PTS binding 2 24 0 6930 0.077 1 0.00029 0 3.2 1.3e-05 0.012 peroxisome targeting signal receptor activity/PTS receptor activity 3 23 17 6913 0.12 0.15 0.0029 0.0025 1.8 5.1e-05 0.025 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 6 20 184 6746 0.23 0.032 0.027 0.027 1.1 5.6e-05 0.025 transcription cofactor activity/transcriptional co-regulator 12 14 975 5955 0.46 0.012 0.14 0.14 0.72 8.8e-05 0.037 regulation of transcription 12 14 988 5942 0.46 0.012 0.14 0.14 0.71 0.0001 0.037 transcription, DNA-dependent 6 20 211 6719 0.23 0.028 0.031 0.03 1 0.00012 0.037 transcription factor binding/TF binding 12 14 1017 5913 0.46 0.012 0.15 0.15 0.7 0.00013 0.04 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 12 14 1031 5899 0.46 0.012 0.15 0.15 0.69 0.00015 0.058 transcription 12 14 1046 5884 0.46 0.011 0.15 0.15 0.69 0.00017 0.062 regulation of cellular metabolism 2 24 4 6926 0.077 0.33 0.00086 0.00058 2.2 0.0002 0.082 regulation of myogenesis Interactions within complex: 215 215 215 225 215 5824 215 5825 225 225 225 5824 225 5825 3065 5195 3065 7704 3065 10401 4286 7942 4286 10401 4286 22797 5191 5194 5191 5195 5191 5264 5191 5830 5194 5195 5194 5824 5194 5830 5195 5195 5195 5824 5195 5830 5264 5264 5465 5465 5465 9611 5465 246329 5469 5469 5469 5914 5824 5825 5825 5825 5830 5830 5905 5905 5905 6613 5914 7704 6477 6477 6477 6907 6613 6613 6613 9759 6907 9611 7704 7704 7704 9611 7704 9759 7704 10014 7942 22797 9611 9759 9611 10014 22797 22797 246329 246329 =============================================================================== Complex CCSB-HI1-union-LC.03 Size of complex: 5 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 4 1 223 6728 0.8 0.018 0.033 0.032 2 5.4e-06 < 0.001 structural molecule activity 3 2 93 6858 0.6 0.031 0.014 0.013 2 2.5e-05 0.002 sensory perception of light 3 2 146 6805 0.6 0.02 0.021 0.021 1.8 9.3e-05 0.014 sensory perception 3 2 231 6720 0.6 0.013 0.034 0.033 1.6 0.00036 0.038 detection of external stimulus/perception of external stimulus Interactions within complex: 1409 1410 1409 1415 1409 1420 1409 3315 1410 1415 1410 1420 1410 3315 1415 1420 1415 3315 1420 3315 =============================================================================== Complex CCSB-HI1-union-LC.19 Size of complex: 29 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 14 15 315 6612 0.48 0.043 0.047 0.045 1.3 8.7e-12 < 0.001 positive regulation of cellular process 12 17 206 6721 0.41 0.055 0.031 0.03 1.4 2.2e-11 < 0.001 regulation of programmed cell death 12 17 219 6708 0.41 0.052 0.033 0.032 1.3 4.3e-11 < 0.001 apoptosis/type I programmed cell death 14 15 371 6556 0.48 0.036 0.055 0.054 1.2 7.3e-11 < 0.001 positive regulation of biological process 8 21 53 6874 0.28 0.13 0.0088 0.0077 1.7 8.1e-11 < 0.001 lymphocyte activation 8 21 63 6864 0.28 0.11 0.01 0.0091 1.6 2.8e-10 < 0.001 immune cell activation 12 17 261 6666 0.41 0.044 0.039 0.038 1.3 3e-10 < 0.001 positive regulation of cellular physiological process 8 21 64 6863 0.28 0.11 0.01 0.0092 1.6 3.2e-10 < 0.001 cell activation 6 23 18 6909 0.21 0.25 0.0035 0.0026 2 3.9e-10 < 0.001 T-cell activation/T cell activation 12 17 269 6658 0.41 0.043 0.04 0.039 1.2 4.2e-10 < 0.001 positive regulation of physiological process 6 23 22 6905 0.21 0.21 0.004 0.0032 1.9 1.1e-09 < 0.001 positive regulation of immune response 6 23 22 6905 0.21 0.21 0.004 0.0032 1.9 1.1e-09 < 0.001 positive regulation of organismal physiological process 5 24 10 6917 0.17 0.33 0.0022 0.0014 2.2 2.6e-09 < 0.001 positive regulation of cell activation 10 19 185 6742 0.34 0.051 0.028 0.027 1.3 3e-09 < 0.001 regulation of apoptosis 12 17 333 6594 0.41 0.035 0.05 0.048 1.1 4.4e-09 < 0.001 programmed cell death 5 24 12 6915 0.17 0.29 0.0024 0.0017 2.1 5.2e-09 < 0.001 regulation of T-cell activation 12 17 342 6585 0.41 0.034 0.051 0.049 1.1 5.9e-09 < 0.001 cell death 12 17 349 6578 0.41 0.033 0.052 0.05 1.1 7.4e-09 < 0.001 death 5 24 17 6910 0.17 0.23 0.0032 0.0025 1.9 2.2e-08 < 0.001 positive regulation of protein metabolism 6 23 40 6887 0.21 0.13 0.0066 0.0058 1.7 2.5e-08 < 0.001 regulation of immune response 5 24 20 6907 0.17 0.2 0.0036 0.0029 1.9 4.4e-08 < 0.001 regulation of lymphocyte activation 5 24 22 6905 0.17 0.19 0.0039 0.0032 1.8 6.6e-08 < 0.001 regulation of cell activation 5 24 24 6903 0.17 0.17 0.0042 0.0035 1.8 9.7e-08 < 0.001 lymphocyte differentiation/lymphocyte cell differentiation/lymphocytic blood cell differentiation 4 25 8 6919 0.14 0.33 0.0017 0.0012 2.2 1.2e-07 < 0.001 positive regulation of T-cell activation 7 22 98 6829 0.24 0.067 0.015 0.014 1.4 1.7e-07 < 0.001 induction of programmed cell death 7 22 98 6829 0.24 0.067 0.015 0.014 1.4 1.7e-07 < 0.001 positive regulation of apoptosis 4 25 10 6917 0.14 0.29 0.002 0.0014 2.1 2.4e-07 < 0.001 positive regulation of lymphocyte activation 7 22 103 6824 0.24 0.064 0.016 0.015 1.3 2.4e-07 < 0.001 positive regulation of programmed cell death 4 25 11 6916 0.14 0.27 0.0022 0.0016 2 3.2e-07 < 0.001 positive regulation of cellular biosynthesis 4 25 12 6915 0.14 0.25 0.0023 0.0017 2 4.3e-07 0.001 positive regulation of biosynthesis 6 23 79 6848 0.21 0.071 0.012 0.011 1.4 1.1e-06 0.001 regulation of organismal physiological process 4 25 16 6911 0.14 0.2 0.0029 0.0023 1.9 1.1e-06 0.001 cellular defense response/cellular defence response 5 24 42 6885 0.17 0.11 0.0068 0.0061 1.6 1.2e-06 0.002 hemopoiesis/blood cell formation/haemopoiesis/hematopoiesis 3 26 3 6924 0.1 0.5 0.00086 0.00043 2.4 1.3e-06 0.002 regulation of interleukin-2 biosynthesis/regulation of IL-2 biosynthesis 3 26 4 6923 0.1 0.43 0.001 0.00058 2.3 2.3e-06 0.002 interleukin-2 biosynthesis/IL-2 biosynthesis 3 26 4 6923 0.1 0.43 0.001 0.00058 2.3 2.3e-06 0.002 T-cell differentiation/T cell differentiation 4 25 20 6907 0.14 0.17 0.0035 0.0029 1.8 2.4e-06 0.002 cytokine metabolism 4 25 21 6906 0.14 0.16 0.0036 0.003 1.8 2.9e-06 0.002 cytokine production 3 26 5 6922 0.1 0.38 0.0012 0.00072 2.2 3.6e-06 0.003 regulation of lymphocyte differentiation 4 25 26 6901 0.14 0.13 0.0043 0.0038 1.7 6.2e-06 0.004 regulation of cellular biosynthesis 11 18 540 6387 0.38 0.02 0.079 0.078 0.87 6.5e-06 0.004 defense response/defence response 5 24 63 6864 0.17 0.074 0.0098 0.0091 1.4 7.6e-06 0.004 positive regulation of metabolism 9 20 365 6562 0.31 0.024 0.054 0.053 0.92 1.3e-05 0.005 immune response 3 26 9 6918 0.1 0.25 0.0017 0.0013 2 1.4e-05 0.005 positive regulation of cytokine biosynthesis 2 27 0 6927 0.069 1 0.00029 0 3.1 1.7e-05 0.007 positive regulation of T-helper cell differentiation 2 27 0 6927 0.069 1 0.00029 0 3.1 1.7e-05 0.007 regulation of T-helper cell differentiation 3 26 10 6917 0.1 0.23 0.0019 0.0014 1.9 1.8e-05 0.007 induction of apoptosis by extracellular signals 3 26 10 6917 0.1 0.23 0.0019 0.0014 1.9 1.8e-05 0.007 positive regulation of protein biosynthesis 4 25 36 6891 0.14 0.1 0.0058 0.0052 1.5 2e-05 0.007 induction of apoptosis/apoptosis signaling/positive regulation of apoptosis 3 26 11 6916 0.1 0.21 0.002 0.0016 1.9 2.3e-05 0.008 positive regulation of cytokine production 3 26 11 6916 0.1 0.21 0.002 0.0016 1.9 2.3e-05 0.008 transition metal ion homeostasis 3 26 13 6914 0.1 0.19 0.0023 0.0019 1.8 3.5e-05 0.008 transition metal ion transport/transition metal transport 3 26 13 6914 0.1 0.19 0.0023 0.0019 1.8 3.5e-05 0.008 T-helper 1 type immune response 11 18 648 6279 0.38 0.017 0.095 0.094 0.78 3.6e-05 0.008 response to biotic stimulus 17 12 1610 5317 0.59 0.01 0.23 0.23 0.66 4.8e-05 0.009 regulation of cellular physiological process 2 27 1 6926 0.069 0.67 0.00043 0.00014 2.6 5e-05 0.017 positive regulation of T-cell differentiation 2 27 1 6926 0.069 0.67 0.00043 0.00014 2.6 5e-05 0.017 T-helper cell differentiation 3 26 15 6912 0.1 0.17 0.0026 0.0022 1.8 5.1e-05 0.017 cell-mediated immune response/T-cell mediated immunity 3 26 15 6912 0.1 0.17 0.0026 0.0022 1.8 5.1e-05 0.017 cellular defense response (sensu Vertebrata)/cellular defence response (sensu Vertebrata) 15 14 1268 5659 0.52 0.012 0.18 0.18 0.68 5.2e-05 0.017 signal transducer activity 5 24 96 6831 0.17 0.05 0.015 0.014 1.2 5.3e-05 0.017 cell differentiation 3 26 16 6911 0.1 0.16 0.0027 0.0023 1.7 6e-05 0.018 immunological synapse 10 19 567 6360 0.34 0.017 0.083 0.082 0.78 6.7e-05 0.018 receptor activity 3 26 17 6910 0.1 0.15 0.0029 0.0025 1.7 7.1e-05 0.018 regulation of cytokine biosynthesis 3 26 19 6908 0.1 0.14 0.0032 0.0027 1.7 9.5e-05 0.022 regulation of cytokine production 2 27 2 6925 0.069 0.5 0.00058 0.00029 2.4 0.0001 0.031 positive regulation of lymphocyte differentiation 17 12 1705 5222 0.59 0.0099 0.25 0.25 0.63 0.0001 0.032 regulation of cellular process 3 26 20 6907 0.1 0.13 0.0033 0.0029 1.6 0.00011 0.034 cytokine biosynthesis/cytokine production/induction of cytokines 5 24 114 6813 0.17 0.042 0.017 0.016 1.1 0.00012 0.034 regulation of protein metabolism 17 12 1720 5207 0.59 0.0098 0.25 0.25 0.63 0.00012 0.034 regulation of physiological process 4 25 59 6868 0.14 0.063 0.0091 0.0085 1.3 0.00012 0.034 positive regulation of cellular metabolism 3 26 21 6906 0.1 0.12 0.0035 0.003 1.6 0.00012 0.036 cysteine-type endopeptidase activity/thiol endopeptidase 6 23 196 6731 0.21 0.03 0.029 0.028 0.98 0.00015 0.039 vesicle-mediated transport/nonselective vesicle transport 2 27 3 6924 0.069 0.4 0.00072 0.00043 2.3 0.00017 0.051 regulation of T-cell differentiation 3 26 29 6898 0.1 0.094 0.0046 0.0042 1.5 0.0003 0.072 regulation of cell differentiation 4 25 79 6848 0.14 0.048 0.012 0.011 1.2 0.00036 0.088 regulation of protein biosynthesis 13 16 1149 5778 0.45 0.011 0.17 0.17 0.61 0.00036 0.088 signal transduction 3 26 32 6895 0.1 0.086 0.005 0.0046 1.4 0.00039 0.093 di-, tri-valent inorganic cation homeostasis 17 12 1888 5039 0.59 0.0089 0.27 0.27 0.57 0.00039 0.093 regulation of biological process/regulation 4 25 82 6845 0.14 0.047 0.012 0.012 1.2 0.00041 0.094 negative regulation of apoptosis Interactions within complex: 355 695 355 841 355 843 355 9994 637 637 637 835 695 695 695 29760 835 835 835 843 835 10392 841 841 841 843 841 8797 841 9191 841 9994 841 10392 843 9191 868 4690 868 29760 914 920 914 5788 920 920 920 940 920 5788 920 7037 920 8797 925 925 925 5788 940 941 940 942 940 5788 941 941 942 942 1759 1759 1759 4690 1759 6455 1759 29763 1759 29993 3077 3077 3077 7037 4690 29760 5788 5788 5788 10507 6455 6455 7018 7018 7018 7037 7037 7037 9994 9994 10392 10392 10507 10507 11252 11252 11252 29763 11252 29993 29763 29763 29763 29993 29993 29993 =============================================================================== Complex CCSB-HI1-union-LC.59 Size of complex: 7 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 4 13 6936 0.43 0.19 0.0023 0.0019 2.6 3.5e-07 < 0.001 replication fork 3 4 13 6936 0.43 0.19 0.0023 0.0019 2.6 3.5e-07 < 0.001 replisome 3 4 128 6821 0.43 0.023 0.019 0.018 1.6 0.00022 0.028 chromosome Interactions within complex: 6117 6117 6117 6118 6117 6119 6118 6119 6118 6774 6119 6119 6774 9111 9111 11117 11117 11117 11117 66036 66036 66036 =============================================================================== Complex CCSB-HI1-union-LC.57 Size of complex: 4 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 1 51 6901 0.75 0.056 0.0078 0.0073 2.5 1.8e-06 < 0.001 DNA-dependent DNA replication 3 1 62 6890 0.75 0.046 0.0093 0.0089 2.4 3.1e-06 < 0.001 DNA replication/DNA biosynthesis/DNA synthesis 4 0 356 6596 1 0.011 0.052 0.051 2.2 7.1e-06 0.002 DNA metabolism 3 1 251 6701 0.75 0.012 0.037 0.036 1.8 0.00019 0.018 pyrophosphatase activity 3 1 251 6701 0.75 0.012 0.037 0.036 1.8 0.00019 0.018 hydrolase activity, acting on acid anhydrides 3 1 251 6701 0.75 0.012 0.037 0.036 1.8 0.00019 0.018 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 0 909 6043 1 0.0044 0.13 0.13 1.8 0.0003 0.027 biopolymer metabolism Interactions within complex: 990 4172 990 23595 4172 5000 5000 23595 =============================================================================== Complex CCSB-HI1-union-LC.49 Size of complex: 12 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 9 13 6931 0.25 0.19 0.0023 0.0019 2.3 2.2e-06 < 0.001 replication fork 3 9 13 6931 0.25 0.19 0.0023 0.0019 2.3 2.2e-06 < 0.001 replisome 2 10 2 6942 0.17 0.5 0.00058 0.00029 2.8 1.6e-05 0.005 delta DNA polymerase complex 2 10 5 6939 0.17 0.29 0.001 0.00072 2.5 5.7e-05 0.016 DNA polymerase complex 3 9 62 6882 0.25 0.046 0.0093 0.0089 1.6 0.00016 0.031 DNA replication/DNA biosynthesis/DNA synthesis 3 9 67 6877 0.25 0.043 0.01 0.0096 1.6 0.0002 0.039 interphase of mitotic cell cycle 3 9 67 6877 0.25 0.043 0.01 0.0096 1.6 0.0002 0.039 interphase/karyostasis/resting phase 5 7 358 6586 0.42 0.014 0.052 0.052 1.1 0.00022 0.041 enzyme regulator activity/enzyme modulator Interactions within complex: 332 332 332 1019 332 56616 1019 1029 1019 5981 1019 5984 1029 1877 1877 10919 5981 5983 5983 5984 8985 8985 8985 10919 27429 56616 27429 57448 56616 56616 56616 57448 =============================================================================== Complex CCSB-HI1-union-LC.29 Size of complex: 24 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 5 19 14 6918 0.21 0.26 0.0027 0.002 2.1 3.5e-09 < 0.001 immunological synapse 17 7 1123 5809 0.71 0.015 0.16 0.16 1.1 4.4e-09 < 0.001 response to stimulus 16 8 1110 5822 0.67 0.014 0.16 0.16 1 4.1e-08 < 0.001 organismal physiological process 13 11 646 6286 0.54 0.02 0.095 0.093 1.1 4.1e-08 < 0.001 response to biotic stimulus 4 20 8 6924 0.17 0.33 0.0017 0.0012 2.3 5.3e-08 < 0.001 MHC protein complex 12 12 539 6393 0.5 0.022 0.079 0.078 1.1 6.1e-08 < 0.001 defense response/defence response 4 20 19 6913 0.17 0.17 0.0033 0.0027 1.9 9.2e-07 < 0.001 antigen processing 4 20 20 6912 0.17 0.17 0.0035 0.0029 1.9 1.1e-06 < 0.001 antigen presentation 9 15 365 6567 0.38 0.024 0.054 0.053 1 2.2e-06 < 0.001 immune response 15 9 1268 5664 0.62 0.012 0.18 0.18 0.86 2.2e-06 < 0.001 signal transducer activity 5 19 67 6865 0.21 0.069 0.01 0.0097 1.5 3.8e-06 0.001 hemostasis 5 19 67 6865 0.21 0.069 0.01 0.0097 1.5 3.8e-06 0.001 wound healing 5 19 69 6863 0.21 0.068 0.011 0.01 1.4 4.3e-06 0.001 coagulation/clotting 15 9 1378 5554 0.62 0.011 0.2 0.2 0.82 6.5e-06 0.001 intrinsic to membrane 5 19 82 6850 0.21 0.057 0.013 0.012 1.4 9.6e-06 0.001 regulation of body fluids 11 13 849 6083 0.46 0.013 0.12 0.12 0.79 5.2e-05 0.02 plasma membrane/bacterial inner membrane/cell membrane/cytoplasmic membrane/juxtamembrane/plasmalemma 10 14 706 6226 0.42 0.014 0.1 0.1 0.8 6.4e-05 0.02 intrinsic to plasma membrane 15 9 1655 5277 0.62 0.009 0.24 0.24 0.72 6.6e-05 0.02 membrane 10 14 776 6156 0.42 0.013 0.11 0.11 0.76 0.00014 0.045 integral to membrane/transmembrane 9 15 632 6300 0.38 0.014 0.092 0.091 0.79 0.00017 0.046 response to stress 9 15 656 6276 0.38 0.014 0.096 0.095 0.77 0.00022 0.061 response to external stimulus 6 18 267 6665 0.25 0.022 0.039 0.039 0.94 0.00026 0.073 response to wounding 8 16 569 6363 0.33 0.014 0.083 0.082 0.76 0.00047 0.096 receptor activity Interactions within complex: 917 6955 917 6964 928 948 928 1839 948 3674 973 973 973 3507 973 3512 1839 4316 2157 2158 2157 3309 2157 7450 2158 2158 3105 6955 3105 10859 3106 3824 3106 6955 3106 10859 3107 3309 3107 10859 3133 3133 3133 3821 3133 3824 3309 3507 3309 6955 3309 7450 3507 3512 3674 7450 3821 3824 4312 4312 4312 4316 4312 63827 4316 63827 6955 6964 7450 7450 =============================================================================== Complex CCSB-HI1-union-LC.01 Size of complex: 8 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 7 1 23 6925 0.88 0.23 0.0043 0.0033 3.2 1e-16 < 0.001 nucleolus 8 0 78 6870 1 0.093 0.012 0.011 3.2 3.9e-16 < 0.001 RNA splicing, via transesterification reactions 8 0 78 6870 1 0.093 0.012 0.011 3.2 3.9e-16 < 0.001 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile/lariat RNA formation 8 0 80 6868 1 0.091 0.013 0.012 3.2 4.7e-16 < 0.001 RNA splicing 8 0 91 6857 1 0.081 0.014 0.013 3.1 1.3e-15 < 0.001 mRNA processing 8 0 145 6803 1 0.052 0.022 0.021 2.9 4.6e-14 < 0.001 ribonucleoprotein complex/RNP 8 0 146 6802 1 0.052 0.022 0.021 2.9 4.8e-14 < 0.001 mRNA metabolism 8 0 183 6765 1 0.042 0.027 0.026 2.8 2.8e-13 < 0.001 RNA processing 8 0 244 6704 1 0.032 0.036 0.035 2.7 2.7e-12 < 0.001 RNA metabolism 8 0 407 6541 1 0.019 0.06 0.059 2.4 1.5e-10 < 0.001 nucleus 8 0 905 6043 1 0.0088 0.13 0.13 2.1 8.6e-08 < 0.001 biopolymer metabolism 8 0 927 6021 1 0.0086 0.13 0.13 2 1e-07 < 0.001 protein complex 7 1 647 6301 0.88 0.011 0.094 0.093 1.7 4.6e-07 < 0.001 non-membrane-bound organelle 7 1 647 6301 0.88 0.011 0.094 0.093 1.7 4.6e-07 < 0.001 intracellular non-membrane-bound organelle 8 0 1355 5593 1 0.0059 0.2 0.2 1.8 2.1e-06 < 0.001 nucleic acid binding 2 6 1 6947 0.25 0.67 0.00043 0.00014 3.3 3.5e-06 < 0.001 snRNA binding 8 0 1589 5359 1 0.005 0.23 0.23 1.8 7.6e-06 0.002 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 3 5 78 6870 0.38 0.037 0.012 0.011 1.7 8.2e-05 0.016 RNA binding 8 0 2517 4431 1 0.0032 0.36 0.36 1.5 0.0003 0.046 intracellular membrane-bound organelle 8 0 2517 4431 1 0.0032 0.36 0.36 1.5 0.0003 0.046 membrane-bound organelle 8 0 2882 4066 1 0.0028 0.42 0.41 1.4 0.00088 0.092 intracellular organelle 8 0 2883 4065 1 0.0028 0.42 0.41 1.4 0.00089 0.1 organelle Interactions within complex: 6606 6606 6606 11157 6606 23658 6606 25804 6606 27257 6606 27258 6606 51690 6606 57819 11157 23658 11157 25804 11157 27257 11157 27258 11157 51690 11157 57819 23658 25804 23658 27257 23658 27258 23658 51690 23658 57819 25804 27257 25804 27258 25804 51690 25804 57819 27257 27258 27257 51690 27257 57819 27258 51690 27258 57819 51690 57819 =============================================================================== Complex CCSB-HI1-union-LC.39 Size of complex: 14 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 5 9 20 6922 0.36 0.2 0.0036 0.0029 2.3 7.7e-10 < 0.001 mRNA transport 5 9 21 6921 0.36 0.19 0.0037 0.003 2.3 9.5e-10 < 0.001 RNA-nucleus export 5 9 22 6920 0.36 0.19 0.0039 0.0032 2.3 1.2e-09 < 0.001 establishment of RNA localization/RNA positioning/RNA recruitment 5 9 22 6920 0.36 0.19 0.0039 0.0032 2.3 1.2e-09 < 0.001 nucleic acid transport 5 9 22 6920 0.36 0.19 0.0039 0.0032 2.3 1.2e-09 < 0.001 RNA transport 5 9 23 6919 0.36 0.18 0.004 0.0033 2.2 1.4e-09 < 0.001 RNA localization 5 9 23 6919 0.36 0.18 0.004 0.0033 2.2 1.4e-09 < 0.001 nucleobase, nucleoside, nucleotide and nucleic acid transport 5 9 24 6918 0.36 0.17 0.0042 0.0035 2.2 1.7e-09 < 0.001 nuclear export/export from nucleus/nucleus export/substance nuclear export 3 11 2 6940 0.21 0.6 0.00072 0.00029 2.9 6.5e-08 < 0.001 caveola/caveolae 6 8 148 6794 0.43 0.039 0.022 0.021 1.5 2.8e-07 < 0.001 mRNA metabolism 5 9 74 6868 0.36 0.063 0.011 0.011 1.7 3.1e-07 < 0.001 nucleocytoplasmic transport/nucleocytoplasmic shuttling 5 9 74 6868 0.36 0.063 0.011 0.011 1.7 3.1e-07 < 0.001 nuclear transport/nucleus transport 6 8 246 6696 0.43 0.024 0.036 0.035 1.3 5e-06 0.002 RNA metabolism 4 10 82 6860 0.29 0.047 0.012 0.012 1.6 2e-05 0.004 RNA splicing, via transesterification reactions 4 10 82 6860 0.29 0.047 0.012 0.012 1.6 2e-05 0.004 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile/lariat RNA formation 4 10 84 6858 0.29 0.045 0.013 0.012 1.5 2.2e-05 0.004 RNA splicing 5 9 186 6756 0.36 0.026 0.027 0.027 1.3 2.4e-05 0.004 RNA processing 4 10 95 6847 0.29 0.04 0.014 0.014 1.5 3.5e-05 0.005 mRNA processing 2 12 10 6932 0.14 0.17 0.0017 0.0014 2.1 0.00025 0.05 mRNA catabolism 5 9 321 6621 0.36 0.015 0.047 0.046 1.1 0.00031 0.06 intracellular transport 2 12 16 6926 0.14 0.11 0.0026 0.0023 1.9 0.00057 0.099 RNA catabolism Interactions within complex: 857 858 857 2316 857 2319 858 2319 975 975 975 3676 1797 1797 1797 2319 1797 5976 2316 3695 3676 3676 3676 3695 5976 65110 9984 10189 9984 57187 9984 84321 10189 57187 10189 65110 10189 84321 =============================================================================== Complex CCSB-HI1-union-LC.05 Size of complex: 16 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 7 9 245 6695 0.44 0.028 0.036 0.035 1.3 6.5e-07 < 0.001 RNA metabolism 4 12 72 6868 0.25 0.053 0.011 0.01 1.5 2.2e-05 0.012 nuclease activity 14 2 2876 4064 0.88 0.0048 0.42 0.41 0.91 0.0002 0.046 intracellular organelle 14 2 2877 4063 0.88 0.0048 0.42 0.41 0.91 0.0002 0.046 organelle 2 14 9 6931 0.12 0.18 0.0016 0.0013 2.1 0.00027 0.063 3'-5' exonuclease activity/3'-5'-exonuclease activity 2 14 9 6931 0.12 0.18 0.0016 0.0013 2.1 0.00027 0.063 exoribonuclease activity 2 14 9 6931 0.12 0.18 0.0016 0.0013 2.1 0.00027 0.063 exoribonuclease activity, producing 5'-phosphomonoesters/exoribonuclease activity, producing 5' phosphomonoesters 13 3 2512 4428 0.81 0.0051 0.36 0.36 0.83 0.00031 0.065 intracellular membrane-bound organelle 13 3 2512 4428 0.81 0.0051 0.36 0.36 0.83 0.00031 0.065 membrane-bound organelle 4 12 150 6790 0.25 0.026 0.022 0.022 1.2 0.00034 0.077 mRNA metabolism 2 14 12 6928 0.12 0.14 0.002 0.0017 2 0.00044 0.096 clathrin vesicle coat 2 14 12 6928 0.12 0.14 0.002 0.0017 2 0.00044 0.096 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters/exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5' phosphomonoesters 2 14 12 6928 0.12 0.14 0.002 0.0017 2 0.00044 0.096 trans-Golgi network transport vesicle/TGN transport vesicle Interactions within complex: 162 164 162 4087 164 164 996 4087 996 8881 3842 8021 3842 10482 4087 8021 4087 8881 4116 4116 4116 10482 7538 8021 7538 11340 7538 26019 7538 54464 7538 118460 8021 10482 10482 10482 11340 26019 11340 29109 11340 51013 11340 54464 11340 118460 26019 26019 26019 51013 26019 54464 26019 118460 29109 29109 51013 54464 51013 118460 54464 118460 =============================================================================== Complex CCSB-HI1-union-LC.43 Size of complex: 15 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 5 10 22 6919 0.33 0.19 0.0039 0.0032 2.2 1.7e-09 < 0.001 apical junction complex 5 10 26 6915 0.33 0.16 0.0045 0.0037 2.1 3.6e-09 < 0.001 apicolateral plasma membrane 5 10 35 6906 0.33 0.12 0.0058 0.005 2 1.4e-08 < 0.001 intercellular junction/cell-cell junction 5 10 60 6881 0.33 0.077 0.0093 0.0086 1.8 1.7e-07 < 0.001 cell junction 2 13 6 6935 0.13 0.25 0.0012 0.00086 2.3 0.00012 0.033 cortical actin cytoskeleton 2 13 8 6933 0.13 0.2 0.0014 0.0012 2.2 0.00019 0.042 cortical cytoskeleton 2 13 12 6929 0.13 0.14 0.002 0.0017 2 0.00039 0.077 cell cortex 4 11 169 6772 0.27 0.023 0.025 0.024 1.2 0.00041 0.077 cytoskeletal protein binding 4 11 187 6754 0.27 0.021 0.027 0.027 1.1 0.00059 0.098 RNA processing Interactions within complex: 118 119 118 6709 119 6709 1365 7122 1365 9076 2035 6709 2035 7307 2035 9414 4179 4179 4179 7525 4950 7525 4950 9414 6427 7307 6427 8233 6427 9406 7122 7122 7307 8233 7307 9406 9076 9414 =============================================================================== Complex CCSB-HI1-union-LC.06 Size of complex: 35 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 6 29 64 6857 0.17 0.086 0.01 0.0092 1.4 1.1e-06 < 0.001 interphase of mitotic cell cycle 6 29 64 6857 0.17 0.086 0.01 0.0092 1.4 1.1e-06 < 0.001 interphase/karyostasis/resting phase 8 27 172 6749 0.23 0.044 0.026 0.025 1.1 2.2e-06 < 0.001 mitotic cell cycle 7 28 166 6755 0.2 0.04 0.025 0.024 1 1.9e-05 < 0.001 regulation of cell cycle/cell cycle control 20 15 1702 5219 0.57 0.012 0.25 0.25 0.61 4.2e-05 0.016 regulation of cellular process 19 16 1608 5313 0.54 0.012 0.23 0.23 0.59 7.3e-05 0.019 regulation of cellular physiological process 19 16 1718 5203 0.54 0.011 0.25 0.25 0.55 0.00019 0.054 regulation of physiological process 20 15 1885 5036 0.57 0.01 0.27 0.27 0.55 0.0002 0.057 regulation of biological process/regulation Interactions within complex: 595 1026 595 9978 808 2100 808 4617 808 5898 808 6929 862 862 862 6929 862 6938 862 220766 1017 1017 1017 1026 1017 1033 1017 9134 1026 7251 1026 9134 1033 1033 1786 7251 1786 8932 2100 4085 2100 7533 3398 3398 3398 4617 3398 6929 3398 6938 3398 9242 3399 3399 3399 4617 3399 6929 4085 4085 4617 4617 4617 6929 5468 5468 5468 10499 5898 5898 5898 11336 5898 55770 6929 6929 6929 6938 6929 9242 6938 9242 7251 7251 7251 8495 7533 10499 8454 8454 8454 9978 8454 84893 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0.41 0.47 0.00014 0.042 intracellular organelle 34 16 2857 4049 0.68 0.012 0.42 0.41 0.47 0.00014 0.042 organelle Interactions within complex: 87 87 87 5585 87 7518 87 8941 87 9124 87 125950 88 5585 88 9124 88 125950 154 2769 154 4985 154 9351 401 5566 401 9464 405 405 405 23462 1020 1020 1020 2580 1020 6418 1020 8941 1080 1080 1080 5174 1080 9351 1244 5174 1244 5962 2280 2280 2280 3708 2580 10053 2670 4221 2670 5174 2670 9124 2735 27148 2735 51684 2736 27148 2736 51684 2769 4985 2769 4986 2769 4988 3001 3148 3001 6418 3148 6418 3708 3710 3708 6262 3710 7225 3710 7226 4221 4791 4791 4791 4791 8945 4869 8290 4869 9464 4985 4986 4985 4988 4985 9737 4988 9737 5189 5190 5189 55670 5190 55670 5566 6262 5566 9351 5566 9464 5962 9351 6418 8290 7225 7225 7225 7226 7518 7518 8945 51684 10053 10618 10618 25865 23462 25865 27148 51684 51684 55670 =============================================================================== Complex CCSB-HI1-union-LC.32 Size of complex: 9 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 6 27 6920 0.33 0.1 0.0043 0.0039 2.1 6e-06 < 0.001 oxygen and reactive oxygen species metabolism/oxygen and ROS metabolism 6 3 983 5964 0.67 0.0061 0.14 0.14 1.1 0.00047 0.075 cytoplasm Interactions within complex: 387 387 387 4168 387 23463 387 50619 1535 1536 1535 4687 1535 4688 1536 4688 4168 4168 4687 4687 4687 4688 4688 5880 5880 23463 5880 50619 =============================================================================== Complex CCSB-HI1-union-LC.02 Size of complex: 6 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 6 0 981 5969 1 0.0061 0.14 0.14 1.9 8.1e-06 0.001 regulation of transcription 6 0 994 5956 1 0.006 0.14 0.14 1.9 8.7e-06 0.001 transcription, DNA-dependent 6 0 1023 5927 1 0.0058 0.15 0.15 1.9 1e-05 0.002 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 6 0 1037 5913 1 0.0058 0.15 0.15 1.9 1.1e-05 0.002 transcription 6 0 1052 5898 1 0.0057 0.15 0.15 1.9 1.2e-05 0.002 regulation of cellular metabolism 6 0 1139 5811 1 0.0052 0.16 0.16 1.8 2e-05 0.003 regulation of metabolism 6 0 1357 5593 1 0.0044 0.2 0.2 1.7 5.6e-05 0.007 nucleic acid binding 6 0 1591 5359 1 0.0038 0.23 0.23 1.6 0.00015 0.017 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 6 0 1621 5329 1 0.0037 0.23 0.23 1.6 0.00016 0.02 regulation of cellular physiological process 6 0 1716 5234 1 0.0035 0.25 0.25 1.6 0.00023 0.027 regulation of cellular process 6 0 1731 5219 1 0.0035 0.25 0.25 1.6 0.00024 0.028 regulation of physiological process 6 0 1899 5051 1 0.0031 0.27 0.27 1.5 0.00042 0.045 regulation of biological process/regulation Interactions within complex: 468 1050 468 1051 468 1053 468 1054 468 10538 1050 1050 1050 1051 1050 1053 1050 1054 1050 10538 1051 1051 1051 1053 1051 1054 1051 10538 1053 1053 1053 1054 1053 10538 1054 1054 1054 10538 =============================================================================== Complex CCSB-HI1-union-LC.82 Size of complex: 4 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 2 12 6940 0.5 0.14 0.002 0.0017 2.7 2.3e-05 0.001 clathrin vesicle coat 2 2 12 6940 0.5 0.14 0.002 0.0017 2.7 2.3e-05 0.001 trans-Golgi network transport vesicle/TGN transport vesicle 2 2 13 6939 0.5 0.13 0.0022 0.0019 2.7 2.6e-05 0.003 transport vesicle/secretory vesicle 2 2 14 6938 0.5 0.12 0.0023 0.002 2.7 3e-05 0.003 Golgi vesicle 2 2 24 6928 0.5 0.077 0.0037 0.0035 2.5 8e-05 0.014 clathrin coat/clathrin cage 2 2 36 6916 0.5 0.053 0.0055 0.0052 2.3 0.00017 0.022 membrane coat 2 2 36 6916 0.5 0.053 0.0055 0.0052 2.3 0.00017 0.022 vesicle coat 2 2 36 6916 0.5 0.053 0.0055 0.0052 2.3 0.00017 0.022 coated membrane 2 2 44 6908 0.5 0.043 0.0066 0.0063 2.2 0.00025 0.027 Golgi vesicle transport 2 2 52 6900 0.5 0.037 0.0078 0.0075 2.1 0.00035 0.031 clathrin-coated vesicle 2 2 53 6899 0.5 0.036 0.0079 0.0076 2.1 0.00036 0.032 Golgi apparatus/Golgi complex/Golgi ribbon Interactions within complex: 8517 8517 8517 26994 23163 23163 23163 26994 26088 26088 26088 26994 =============================================================================== Complex CCSB-HI1-union-LC.31 Size of complex: 13 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 6 7 318 6625 0.46 0.019 0.047 0.046 1.3 1.3e-05 0.001 establishment of protein localization/protein positioning/protein recruitment 6 7 322 6621 0.46 0.018 0.047 0.046 1.3 1.4e-05 0.002 protein localization 5 8 220 6723 0.38 0.022 0.032 0.032 1.3 3.5e-05 0.011 protein transport/enzyme transport 3 10 43 6900 0.23 0.065 0.0066 0.0062 1.7 7.4e-05 0.017 Golgi vesicle transport 8 5 967 5976 0.62 0.0082 0.14 0.14 0.98 9.7e-05 0.021 establishment of localization 8 5 973 5970 0.62 0.0082 0.14 0.14 0.98 0.0001 0.021 localization/establishment and maintenance of position/establishment and maintenance of substrate location/positioning 5 8 321 6622 0.38 0.015 0.047 0.046 1.1 0.00021 0.043 intracellular transport 4 9 168 6775 0.31 0.023 0.025 0.024 1.3 0.00022 0.047 guanyl nucleotide binding 7 6 855 6088 0.54 0.0081 0.12 0.12 0.91 0.00038 0.07 transport 4 9 198 6745 0.31 0.02 0.029 0.029 1.2 0.0004 0.07 vesicle-mediated transport/nonselective vesicle transport 4 9 219 6724 0.31 0.018 0.032 0.032 1.2 0.00059 0.095 nucleoside-triphosphatase activity/nucleoside triphosphatase activity Interactions within complex: 4644 5873 4644 79083 4735 5413 4735 6804 4735 10801 4735 23157 5413 6804 5873 6804 5873 79083 6804 6845 6845 8417 8417 10228 8674 8675 8674 10228 8675 10228 10801 23157 =============================================================================== Complex CCSB-HI1-union-LC.55 Size of complex: 3 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 0 51 6902 1 0.056 0.0078 0.0073 3 4.4e-07 0.001 DNA-dependent DNA replication 3 0 62 6891 1 0.046 0.0093 0.0089 2.9 7.8e-07 0.001 DNA replication/DNA biosynthesis/DNA synthesis 3 0 357 6596 1 0.0083 0.052 0.051 2.1 0.00014 0.016 DNA metabolism Interactions within complex: 4174 5001 4174 8317 5001 8317 =============================================================================== Complex CCSB-HI1-union-LC.71 Size of complex: 3 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 1 8 6945 0.67 0.2 0.0014 0.0012 3.1 5.6e-06 0.001 AMP binding 2 1 10 6943 0.67 0.17 0.0017 0.0014 3 8.2e-06 0.001 cyclic nucleotide binding 2 1 37 6916 0.67 0.051 0.0056 0.0053 2.5 9.2e-05 0.004 protein kinase regulator activity 2 1 41 6912 0.67 0.047 0.0062 0.0059 2.4 0.00011 0.008 kinase regulator activity 2 1 44 6909 0.67 0.043 0.0066 0.0063 2.4 0.00013 0.012 unlocalized protein complex Interactions within complex: 5573 5575 5573 8165 5575 8165 =============================================================================== Complex CCSB-HI1-union-LC.79 Size of complex: 5 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 2 51 6900 0.6 0.056 0.0078 0.0073 2.3 4.4e-06 0.002 glycosaminoglycan binding 3 2 55 6896 0.6 0.052 0.0083 0.0079 2.2 5.4e-06 0.002 polysaccharide binding 3 2 59 6892 0.6 0.048 0.0089 0.0085 2.2 6.7e-06 0.002 pattern binding/pattern recognition activity 3 2 120 6831 0.6 0.024 0.018 0.017 1.9 5.3e-05 0.014 carbohydrate binding 5 0 1278 5673 1 0.0039 0.18 0.18 1.7 0.00021 0.028 signal transducer activity 2 3 37 6914 0.4 0.051 0.0056 0.0053 2.1 0.0003 0.038 blood vessel development 2 3 37 6914 0.4 0.051 0.0056 0.0053 2.1 0.0003 0.038 blood vessel morphogenesis 2 3 37 6914 0.4 0.051 0.0056 0.0053 2.1 0.0003 0.038 vasculature development 2 3 38 6913 0.4 0.05 0.0058 0.0055 2.1 0.00032 0.041 transmembrane receptor protein tyrosine kinase activity Interactions within complex: 2254 2254 2254 2263 2263 2263 2263 5335 3791 5335 3791 7422 7422 7422 =============================================================================== Complex CCSB-HI1-union-LC.36 Size of complex: 6 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 3 44 6906 0.5 0.064 0.0068 0.0063 2.2 5.7e-06 0.002 endocytosis/nonselective vesicle endocytosis/vesicle endocytosis 4 2 198 6752 0.67 0.02 0.029 0.028 1.8 9.9e-06 0.002 vesicle-mediated transport/nonselective vesicle transport 2 4 5 6945 0.33 0.29 0.001 0.00072 2.8 1.3e-05 0.002 synaptic vesicle transport Interactions within complex: 274 274 274 6456 274 8491 274 8867 6453 8867 6453 9522 6456 8491 6456 8867 9522 9522 =============================================================================== Complex CCSB-HI1-union-LC.67 Size of complex: 3 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 1 29 6924 0.67 0.065 0.0045 0.0042 2.6 5.8e-05 0.002 interleukin binding/IL binding 2 1 38 6915 0.67 0.05 0.0058 0.0055 2.5 9.6e-05 0.003 hematopoietin/interferon-class (D200-domain) cytokine receptor activity 2 1 61 6892 0.67 0.032 0.0091 0.0088 2.3 0.00024 0.014 cytokine binding Interactions within complex: 3560 3600 3560 3601 3600 3601 =============================================================================== Complex CCSB-HI1-union-LC.11 Size of complex: 16 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 4 12 53 6887 0.25 0.07 0.0082 0.0076 1.7 6.9e-06 0.002 transcription factor complex 7 9 408 6532 0.44 0.017 0.06 0.059 1.1 1.8e-05 0.005 nucleus 3 13 26 6914 0.19 0.1 0.0042 0.0037 1.8 3.5e-05 0.009 transcription initiation 9 7 926 6014 0.56 0.0096 0.13 0.13 0.92 6.5e-05 0.016 protein complex 3 13 45 6895 0.19 0.062 0.0069 0.0065 1.6 0.00016 0.039 DNA-directed RNA polymerase II, holoenzyme 4 12 131 6809 0.25 0.03 0.019 0.019 1.3 0.00021 0.046 nucleoplasm 13 3 2512 4428 0.81 0.0051 0.36 0.36 0.83 0.00031 0.071 intracellular membrane-bound organelle 13 3 2512 4428 0.81 0.0051 0.36 0.36 0.83 0.00031 0.071 membrane-bound organelle 3 13 65 6875 0.19 0.044 0.0098 0.0094 1.4 0.00046 0.097 RNA polymerase II transcription factor activity Interactions within complex: 1270 1270 1270 1271 1270 3977 1271 3977 1271 10513 2962 2963 2962 5701 2963 2963 2963 6908 3977 5451 4331 5451 4331 5452 4800 5451 4800 10513 4800 23051 5451 5451 5451 6908 5452 5452 5452 6908 5700 5701 5700 5708 5700 5711 5701 5708 5701 5711 5701 6908 5708 5711 10513 10513 23051 23051 =============================================================================== Complex CCSB-HI1-union-LC.27 Size of complex: 4 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 1 69 6883 0.75 0.042 0.01 0.0099 2.4 4.2e-06 0.002 hemostasis 3 1 69 6883 0.75 0.042 0.01 0.0099 2.4 4.2e-06 0.002 wound healing 3 1 71 6881 0.75 0.041 0.011 0.01 2.4 4.6e-06 0.002 coagulation/clotting 3 1 84 6868 0.75 0.034 0.013 0.012 2.3 7.5e-06 0.004 regulation of body fluids 2 2 23 6929 0.5 0.08 0.0036 0.0033 2.5 7.4e-05 0.017 blood coagulation/blood clotting 3 1 270 6682 0.75 0.011 0.039 0.039 1.8 0.00023 0.027 response to wounding Interactions within complex: 5104 5624 5104 7056 5196 5196 5196 5624 5196 7056 5624 5624 5624 7056 =============================================================================== Complex CCSB-HI1-union-LC.42 Size of complex: 22 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 6 16 136 6798 0.27 0.042 0.02 0.02 1.3 3.7e-06 0.002 cell adhesion 2 20 3 6931 0.091 0.4 0.00072 0.00043 2.4 9.5e-05 0.032 gas transport 2 20 6 6928 0.091 0.25 0.0012 0.00087 2.1 0.00026 0.079 heterophilic cell adhesion 2 20 7 6927 0.091 0.22 0.0013 0.001 2.1 0.00034 0.091 tetrapyrrole binding/porphyrin binding Interactions within complex: 2151 58494 2151 83700 2274 2274 2274 3689 2274 9457 3040 3040 3040 3043 3040 3048 3043 3043 3043 3240 3048 3048 3240 3684 3240 3689 3384 3684 3384 3689 3384 30835 3482 5328 3482 10226 3684 3689 3684 5329 3684 83700 3689 10048 4811 4811 4811 5328 5328 5328 5328 5329 5328 6768 6278 6278 6278 10048 6768 6768 7082 58494 7082 83700 9457 9457 10226 10226 30835 30835 58494 83700 =============================================================================== Complex CCSB-HI1-union-LC.48 Size of complex: 22 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 15 7 1655 5279 0.68 0.009 0.24 0.24 0.82 1.4e-05 0.003 membrane 3 19 16 6918 0.14 0.16 0.0027 0.0023 1.9 2.6e-05 0.005 immunological synapse 10 12 850 6084 0.45 0.012 0.12 0.12 0.78 0.00013 0.033 plasma membrane/bacterial inner membrane/cell membrane/cytoplasmic membrane/juxtamembrane/plasmalemma Interactions within complex: 915 919 915 926 919 919 919 2534 926 926 1063 1063 1063 8315 2534 2534 2534 2904 2534 4868 2534 6693 2904 3603 3265 3265 3265 3956 3265 8315 3603 3603 3603 3759 3603 3761 3603 10534 3759 8573 3761 8573 3761 64130 3956 6693 4868 7827 4868 8573 4868 55243 7827 55243 8315 8315 8573 8573 8573 23705 9311 57120 9311 64130 10534 10534 23705 23705 55243 55243 57120 57120 =============================================================================== Complex CCSB-HI1-union-LC.12 Size of complex: 8 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 5 3 324 6624 0.62 0.015 0.047 0.047 1.5 1.1e-05 0.003 positive regulation of cellular process 4 4 164 6784 0.5 0.024 0.024 0.024 1.6 2.1e-05 0.006 protein kinase cascade 3 5 51 6897 0.38 0.056 0.0078 0.0073 1.9 2.4e-05 0.006 regulation of I-kappaB kinase/NF-kappaB cascade 5 3 380 6568 0.62 0.013 0.055 0.055 1.4 2.5e-05 0.006 positive regulation of biological process 3 5 58 6890 0.38 0.049 0.0088 0.0083 1.9 3.5e-05 0.007 positive regulation of signal transduction 3 5 69 6879 0.38 0.042 0.01 0.0099 1.8 5.7e-05 0.014 I-kappaB kinase/NF-kappaB cascade 3 5 111 6837 0.38 0.026 0.016 0.016 1.6 0.00023 0.034 regulation of signal transduction Interactions within complex: 608 10673 608 407977 7188 8767 7188 23495 7188 55504 7189 8767 7189 23495 7189 55504 10673 10673 10673 23495 10673 407977 23495 407977 =============================================================================== Complex CCSB-HI1-union-LC.65 Size of complex: 6 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 6 0 981 5969 1 0.0061 0.14 0.14 1.9 8.1e-06 0.004 regulation of transcription 6 0 994 5956 1 0.006 0.14 0.14 1.9 8.7e-06 0.004 transcription, DNA-dependent 6 0 1023 5927 1 0.0058 0.15 0.15 1.9 1e-05 0.005 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 6 0 1037 5913 1 0.0058 0.15 0.15 1.9 1.1e-05 0.005 transcription 6 0 1052 5898 1 0.0057 0.15 0.15 1.9 1.2e-05 0.005 regulation of cellular metabolism 6 0 1139 5811 1 0.0052 0.16 0.16 1.8 2e-05 0.006 regulation of metabolism 5 1 614 6336 0.83 0.0081 0.089 0.088 1.6 3.1e-05 0.009 DNA binding 6 0 1357 5593 1 0.0044 0.2 0.2 1.7 5.6e-05 0.012 nucleic acid binding 5 1 729 6221 0.83 0.0068 0.11 0.1 1.5 7.1e-05 0.014 transcription regulator activity 6 0 1591 5359 1 0.0038 0.23 0.23 1.6 0.00015 0.022 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 6 0 1621 5329 1 0.0037 0.23 0.23 1.6 0.00016 0.024 regulation of cellular physiological process 6 0 1716 5234 1 0.0035 0.25 0.25 1.6 0.00023 0.032 regulation of cellular process 6 0 1731 5219 1 0.0035 0.25 0.25 1.6 0.00024 0.034 regulation of physiological process 6 0 1899 5051 1 0.0031 0.27 0.27 1.5 0.00042 0.051 regulation of biological process/regulation 2 4 44 6906 0.33 0.043 0.0066 0.0063 1.9 0.00063 0.072 ligand-dependent nuclear receptor activity/nuclear hormone receptor Interactions within complex: 2063 2063 2063 2099 2099 2099 2099 7494 4778 4778 4778 58487 7494 7494 7494 22926 7494 58487 22926 22926 22926 58487 58487 58487 =============================================================================== Complex CCSB-HI1-union-LC.77 Size of complex: 6 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 4 7 6943 0.33 0.22 0.0013 0.001 2.7 2.2e-05 0.004 leading edge/front of cell 3 3 83 6867 0.5 0.035 0.012 0.012 1.9 3.6e-05 0.009 actin filament-based process/microfilament-based process 2 4 10 6940 0.33 0.17 0.0017 0.0014 2.6 4.1e-05 0.009 regulation of actin filament length 2 4 12 6938 0.33 0.14 0.002 0.0017 2.5 5.6e-05 0.011 actin polymerization and/or depolymerization 3 3 116 6834 0.5 0.025 0.017 0.017 1.8 9.4e-05 0.016 regulation of protein metabolism 2 4 21 6929 0.33 0.087 0.0033 0.003 2.3 0.00016 0.022 regulation of cell organization and biogenesis 6 0 1621 5329 1 0.0037 0.23 0.23 1.6 0.00016 0.022 regulation of cellular physiological process 2 4 25 6925 0.33 0.074 0.0039 0.0036 2.2 0.00022 0.035 cell projection 6 0 1716 5234 1 0.0035 0.25 0.25 1.6 0.00023 0.035 regulation of cellular process 6 0 1731 5219 1 0.0035 0.25 0.25 1.6 0.00024 0.036 regulation of physiological process 2 4 30 6920 0.33 0.062 0.0046 0.0043 2.1 0.0003 0.044 negative regulation of protein metabolism 3 3 177 6773 0.5 0.017 0.026 0.025 1.6 0.00032 0.045 cytoskeleton organization and biogenesis 2 4 34 6916 0.33 0.056 0.0052 0.0049 2 0.00039 0.051 neurite morphogenesis/neurite formation/neurite growth 6 0 1899 5051 1 0.0031 0.27 0.27 1.5 0.00042 0.053 regulation of biological process/regulation 2 4 36 6914 0.33 0.053 0.0055 0.0052 2 0.00043 0.053 actin cytoskeleton organization and biogenesis 5 1 1140 5810 0.83 0.0044 0.16 0.16 1.3 0.00062 0.068 regulation of metabolism Interactions within complex: 322 356 322 7024 322 51466 356 4297 4297 4297 5217 5217 5217 51466 7024 7024 =============================================================================== Complex CCSB-HI1-union-LC.75 Size of complex: 8 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 4 4 137 6811 0.5 0.028 0.02 0.02 1.7 1.1e-05 0.004 enzyme linked receptor protein signaling pathway/enzyme linked receptor protein signalling pathway 4 4 202 6746 0.5 0.019 0.03 0.029 1.5 4.8e-05 0.011 regulation of cell proliferation 7 1 1276 5672 0.88 0.0055 0.18 0.18 1.3 4.8e-05 0.011 signal transducer activity 4 4 216 6732 0.5 0.018 0.032 0.031 1.5 6.2e-05 0.014 cell proliferation 4 4 269 6679 0.5 0.015 0.039 0.039 1.4 0.00014 0.023 positive regulation of cellular physiological process 4 4 277 6671 0.5 0.014 0.04 0.04 1.4 0.00016 0.03 positive regulation of physiological process 4 4 325 6623 0.5 0.012 0.047 0.047 1.3 0.0003 0.051 positive regulation of cellular process 4 4 381 6567 0.5 0.01 0.055 0.055 1.2 0.00054 0.079 positive regulation of biological process Interactions within complex: 780 780 780 6464 2059 2059 2059 6464 2321 2321 2321 5228 2321 6464 2321 7423 4035 5054 4035 6464 5054 5054 5228 5228 7423 7423 =============================================================================== Complex CCSB-HI1-union-LC.34 Size of complex: 5 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 5 0 995 5956 1 0.005 0.14 0.14 1.8 6.1e-05 0.008 transcription, DNA-dependent 5 0 1038 5913 1 0.0048 0.15 0.15 1.8 7.5e-05 0.009 transcription 4 1 615 6336 0.8 0.0065 0.089 0.088 1.5 0.00029 0.033 DNA binding 4 1 730 6221 0.8 0.0054 0.11 0.11 1.4 0.00056 0.052 transcription regulator activity 5 0 1592 5359 1 0.0031 0.23 0.23 1.6 0.00063 0.06 nucleobase, nucleoside, nucleotide and nucleic acid metabolism Interactions within complex: 861 861 861 863 861 865 861 9139 863 863 863 8841 863 9139 865 865 865 9139 8841 8841 =============================================================================== Complex CCSB-HI1-union-LC.72 Size of complex: 3 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 1 44 6909 0.67 0.043 0.0066 0.0063 2.4 0.00013 0.011 potassium channel activity 2 1 68 6885 0.67 0.029 0.01 0.0098 2.2 0.0003 0.02 voltage-gated ion channel activity/voltage gated ion channel activity/voltage-dependent ion channel activity Interactions within complex: 805 3785 805 3786 3785 3786 =============================================================================== Complex CCSB-HI1-union-LC.51 Size of complex: 20 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 18 1 6935 0.1 0.67 0.00043 0.00014 2.8 2.4e-05 0.012 kinesin complex 9 11 873 6063 0.45 0.01 0.13 0.13 0.76 0.00037 0.085 cation binding Interactions within complex: 779 6261 779 6717 779 9699 1856 1856 1856 10127 5861 8615 5861 10567 5864 5864 5864 9699 5864 10567 5867 9371 5867 10567 5910 22920 5910 51562 6261 6261 6717 6717 6717 25801 7572 54925 7572 55663 8615 8615 9371 22920 9699 10567 10127 55663 10567 10567 25801 25801 51562 51562 51562 85359 54925 54925 54925 55663 55663 85359 =============================================================================== Complex CCSB-HI1-union-LC.50 Size of complex: 14 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 11 33 6909 0.21 0.083 0.0052 0.0048 1.8 4.5e-05 0.012 small protein conjugating enzyme activity Interactions within complex: 3064 3064 3064 3092 3064 3093 3092 3092 3093 4738 4287 5887 4287 7415 4738 5710 4738 9040 4738 51667 5710 5887 5710 51667 7311 7311 7311 10013 7415 7415 7415 10013 9040 221184 10013 54880 54880 221184 =============================================================================== Complex CCSB-HI1-union-LC.25 Size of complex: 71 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 7 64 79 6806 0.099 0.081 0.012 0.011 1 2.4e-05 0.013 negative regulation of apoptosis 7 64 89 6796 0.099 0.073 0.014 0.013 0.95 5e-05 0.019 negative regulation of programmed cell death 10 61 221 6664 0.14 0.043 0.033 0.032 0.71 0.0001 0.061 apoptosis/type I programmed cell death 9 62 186 6699 0.13 0.046 0.028 0.027 0.74 0.00015 0.069 regulation of apoptosis Interactions within complex: 302 6277 302 6281 309 1380 309 6271 396 396 396 998 462 462 462 2147 578 581 578 596 578 4170 581 596 581 4170 596 664 596 665 596 5515 596 5530 596 5663 596 6647 629 629 629 721 664 664 664 665 664 8834 665 665 665 8834 721 1378 898 8161 898 55294 988 8458 988 81620 998 998 998 10602 998 50855 998 56288 998 57381 998 81704 1045 1045 1045 6927 1378 1380 1380 1380 1499 5175 1499 5663 1499 5784 1499 5792 1499 5795 1499 6925 1499 6927 1499 6934 1499 55591 1674 1832 1674 6271 1832 1832 1832 3728 1832 5175 2147 2147 2147 2243 2243 2243 2243 3690 3476 4281 3476 5515 3476 11043 3690 5175 3728 5175 3728 5784 3728 5792 3728 5795 3728 6934 4092 8458 4092 56288 4133 4133 4133 4647 4170 4170 4175 4175 4175 51053 4175 81620 4281 11043 4647 10083 4647 55591 4647 64072 5092 5092 5092 6927 5175 5175 5530 5590 5530 6647 5590 50855 5590 60312 5663 5663 5663 6934 5663 23385 5663 29979 5663 55294 5663 83464 6271 6271 6271 6286 6271 27101 6277 6277 6277 27101 6281 6281 6286 6286 6286 27101 6310 6310 6310 8161 6500 6500 6500 27101 6500 55294 6647 6647 6647 9973 6925 6925 6927 6927 8161 8161 9973 9973 10083 10083 10083 64072 10602 10602 11043 11043 23385 83464 29979 29979 50855 50855 50855 56288 51053 81620 57381 81704 60312 60312 =============================================================================== Complex CCSB-HI1-union-LC.61 Size of complex: 3 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 3 0 342 6611 1 0.0087 0.05 0.049 2.1 0.00012 0.015 programmed cell death 3 0 351 6602 1 0.0085 0.051 0.05 2.1 0.00013 0.016 cell death 3 0 358 6595 1 0.0083 0.052 0.051 2.1 0.00014 0.016 death Interactions within complex: 7133 7185 7133 10293 7185 10293 =============================================================================== Complex CCSB-HI1-union-LC.20 Size of complex: 11 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 9 9 6936 0.18 0.18 0.0016 0.0013 2.3 0.00012 0.027 DNA damage response, signal transduction Interactions within complex: 545 672 545 11200 672 672 672 1487 672 5932 672 7392 672 8543 672 11200 1487 5932 1487 8543 5932 8543 5932 22806 7391 7391 7391 7392 7392 7392 22806 22806 22806 64376 22807 22807 22807 64376 64376 64376 =============================================================================== Complex CCSB-HI1-union-LC.07 Size of complex: 4 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 4 0 983 5969 1 0.0041 0.14 0.14 1.7 0.0004 0.042 regulation of transcription 4 0 996 5956 1 0.004 0.14 0.14 1.7 0.00042 0.043 transcription, DNA-dependent 4 0 1025 5927 1 0.0039 0.15 0.15 1.7 0.00048 0.045 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 4 0 1039 5913 1 0.0038 0.15 0.15 1.7 0.0005 0.048 transcription 4 0 1054 5898 1 0.0038 0.15 0.15 1.7 0.00053 0.052 regulation of cellular metabolism Interactions within complex: 4783 4783 4783 10488 4783 84699 4783 90993 10488 10488 10488 84699 10488 90993 84699 84699 84699 90993 90993 90993 =============================================================================== Complex CCSB-HI1-union-LC.40 Size of complex: 21 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 4 17 92 6843 0.19 0.042 0.014 0.013 1.3 0.00017 0.046 translation/protein translation 8 13 651 6284 0.38 0.012 0.095 0.094 0.78 0.00041 0.091 response to biotic stimulus Interactions within complex: 634 634 634 1088 634 4680 634 5829 929 3959 929 4057 1088 4680 1291 3959 1291 5829 1933 1937 1933 3035 1937 3035 3005 3843 3005 10527 3035 6125 3843 6125 3933 4057 3933 4069 3959 3959 4057 4069 5315 5315 5315 5829 5829 5829 5829 6125 5829 6181 5829 6742 5829 8815 6125 10527 6181 6181 6742 6742 8815 8815 =============================================================================== Complex CCSB-HI1-union-LC.73 Size of complex: 5 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 3 51 6900 0.4 0.038 0.0076 0.0073 2 0.00056 0.049 nucleotidyltransferase activity Interactions within complex: 891 5111 891 7088 5111 5111 5111 5425 5111 26073 5425 26073 7088 7088 =============================================================================== Complex CCSB-HI1-union-LC.78 Size of complex: 5 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 3 52 6899 0.4 0.037 0.0078 0.0075 2 0.00058 0.067 DNA-dependent DNA replication Interactions within complex: 166 166 166 3146 177 3146 177 6285 6282 6282 6282 6285 6285 6285 =============================================================================== Complex CCSB-HI1-union-LC.66 Size of complex: 9 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 2 7 24 6923 0.22 0.077 0.0037 0.0035 2 0.00048 0.076 transmembrane receptor protein serine/threonine kinase signaling pathway/transmembrane receptor protein serine/threonine kinase signalling pathway 3 6 138 6809 0.33 0.021 0.02 0.02 1.4 0.00063 0.083 enzyme linked receptor protein signaling pathway/enzyme linked receptor protein signalling pathway Interactions within complex: 93 3624 93 3626 93 6643 93 9392 3624 3624 3624 3626 4089 4089 4089 4149 4089 7030 4089 9392 4149 4149 4149 4335 4335 4335 6643 6643 7030 7030 =============================================================================== Complex CCSB-HI1-union-LC.58 Size of complex: 9 Size of universe: 6956 I&C I&!C !I&C !I&!C P(C|I) P(I|C) P(C) P(C|!I) lod p_raw p_adj name 6 3 983 5964 0.67 0.0061 0.14 0.14 1.1 0.00047 0.078 cytoplasm Interactions within complex: 4841 4841 4841 8379 4841 9513 8379 8379 9513 9513 9513 10197 9513 10313 9513 22978 9513 57142 9513 151871 9513 283518 10197 10197 10313 10313 10313 57142 22978 22978 151871 151871 283518 283518 =============================================================================== Complex CCSB-HI1-union-LC.15 Size of complex: 9 Interactions within complex: 3281 3281 3281 51019 4645 8766 4645 9230 4645 22841 4645 57111 8766 22841 8766 84440 9230 10133 9230 22841 10133 51019 22841 57111 22841 84440 =============================================================================== Complex CCSB-HI1-union-LC.91 Size of complex: 3 Interactions within complex: 4208 4208 4208 117581 6720 6720 6720 117581 =============================================================================== Complex CCSB-HI1-union-LC.56 Size of complex: 3 Interactions within complex: 25 25 25 2885 25 7275 2885 2885 2885 7275 =============================================================================== Complex CCSB-HI1-union-LC.45 Size of complex: 32 Interactions within complex: 801 818 801 1130 801 4656 801 6622 818 6236 818 6772 993 1523 993 4217 993 7529 1130 1460 1130 7529 1460 1460 1460 9616 1523 9672 2638 2638 2638 4036 2944 2944 2944 2946 2944 4217 2946 2946 3439 3558 3439 10379 3558 3558 3558 3559 3558 4804 3559 3559 4036 4192 4036 7038 4036 10755 4192 6772 4192 9672 4217 4217 4656 4656 4803 4803 4803 4804 4803 4914 4804 4909 4804 4914 4804 9500 4909 4909 4914 4914 4914 10755 6236 7169 6622 7529 6622 7846 6772 6772 6772 10379 7038 7038 7169 7169 7529 7529 7846 9672 9500 9500 9616 9616 10755 10755 =============================================================================== Complex CCSB-HI1-union-LC.83 Size of complex: 4 Interactions within complex: 5612 5612 5612 6789 6789 6789 6789 83593 11186 11186 11186 83593 83593 83593 =============================================================================== Complex CCSB-HI1-union-LC.85 Size of complex: 3 Interactions within complex: 1950 1950 1950 7448 7040 7040 7040 7448 7448 7448 =============================================================================== Complex CCSB-HI1-union-LC.89 Size of complex: 3 Interactions within complex: 1303 1303 1303 7094 7094 7094 7094 26136 26136 26136 =============================================================================== Complex CCSB-HI1-union-LC.60 Size of complex: 3 Interactions within complex: 604 5467 604 51564 5467 5467 5467 51564 =============================================================================== Complex CCSB-HI1-union-LC.88 Size of complex: 3 Interactions within complex: 3745 3745 3745 6616 6616 8676 8676 8676 =============================================================================== Complex CCSB-HI1-union-LC.84 Size of complex: 4 Interactions within complex: 3251 3251 3251 55093 51171 51171 51171 55093 55093 79077 79077 79077 =============================================================================== Complex CCSB-HI1-union-LC.80 Size of complex: 4 Interactions within complex: 3458 3458 3458 3459 3459 3459 3459 3716 3716 10419 10419 10419 =============================================================================== Complex CCSB-HI1-union-LC.92 Size of complex: 2 Interactions within complex: 3276 3276 3276 10656 10656 10656 =============================================================================== Complex CCSB-HI1-union-LC.74 Size of complex: 8 Interactions within complex: 71 71 71 8655 71 10134 834 834 834 10134 2597 2597 2597 8655 4831 4831 4831 7431 7431 7431 7431 8655 7431 60491 8655 8655 10134 10134 60491 60491 =============================================================================== Complex CCSB-HI1-union-LC.95 Size of complex: 2 Interactions within complex: 6850 6850 6850 27240 27240 27240 =============================================================================== Complex CCSB-HI1-union-LC.90 Size of complex: 3 Interactions within complex: 2288 2288 2288 2908 2908 2908 2908 3557 3557 3557 =============================================================================== Complex CCSB-HI1-union-LC.81 Size of complex: 4 Interactions within complex: 3297 7520 3297 10923 7297 7297 7297 7520 10923 10923 =============================================================================== Complex CCSB-HI1-union-LC.96 Size of complex: 2 Interactions within complex: 5657 5657 5657 7124 7124 7124 =============================================================================== Complex CCSB-HI1-union-LC.93 Size of complex: 2 Interactions within complex: 1387 1387 1387 4094 4094 4094 =============================================================================== Complex CCSB-HI1-union-LC.94 Size of complex: 2 Interactions within complex: 650 650 650 7042 7042 7042 =============================================================================== Complex CCSB-HI1-union-LC.52 Size of complex: 32 Interactions within complex: 358 358 358 79734 373 373 373 23062 373 80308 373 84708 377 23062 377 23647 760 6521 760 6548 1635 1635 1635 84708 2203 2203 2203 84708 5050 5050 5050 27111 5050 84708 6303 6303 6303 23549 6303 84708 6521 6521 6548 54997 7138 7138 7138 116225 8576 8576 8576 22934 8576 54507 8576 79734 10179 10363 10179 27316 10363 10363 10363 54997 22934 22934 22934 84708 23062 23062 23549 54507 23647 23647 27111 27111 27316 84708 51074 51074 51074 84708 51076 51076 51076 84708 54550 54550 54550 84708 54997 54997 55577 55577 55577 84708 59349 59349 59349 84708 79734 79734 79734 84708 80308 80308 84708 253980 116225 253980 =============================================================================== Complex CCSB-HI1-union-LC.54 Size of complex: 3 Interactions within complex: 1628 1628 1628 3131 1628 7008 3131 3131 3131 7008 7008 7008 =============================================================================== Complex CCSB-HI1-union-LC.53 Size of complex: 3 Interactions within complex: 2354 8061 2354 11016 8061 11016 11016 11016 =============================================================================== Complex CCSB-HI1-union-LC.30 Size of complex: 13 Interactions within complex: 642 642 642 7329 1107 6304 1107 7329 1107 10320 1911 1912 1911 7329 1911 51460 1912 1912 1912 51460 2120 2120 2120 7329 2332 7329 2332 8087 2332 26999 6304 6304 6304 7329 7329 10320 7329 93487 8087 8087 8087 26999 93487 93487 =============================================================================== Complex CCSB-HI1-union-LC.76 Size of complex: 6 Interactions within complex: 392 392 392 663 392 5295 663 663 3190 3190 3190 5295 5295 5925 5925 5925 5925 7052 7052 7052 =============================================================================== Complex CCSB-HI1-union-LC.68 Size of complex: 12 Interactions within complex: 3551 5610 3551 7128 3551 8518 3551 9020 5610 6895 5866 5866 5866 117177 6895 6895 7128 7128 7128 8887 7277 51762 7277 90627 8518 9020 8887 90627 9020 9020 51762 117177 =============================================================================== Complex CCSB-HI1-union-LC.97 Size of complex: 2 Interactions within complex: 2874 2874 2874 79173 79173 79173 =============================================================================== Complex CCSB-HI1-union-LC.64 Size of complex: 7 Interactions within complex: 952 2214 952 3932 962 2773 962 3932 1604 1604 1604 3932 2214 3932 2773 2773 3932 3932 3932 7070 7070 7070 =============================================================================== Complex CCSB-HI1-union-LC.87 Size of complex: 3 Interactions within complex: 4088 4088 4088 10691 4088 11171 10691 10691 11171 11171 =============================================================================== Complex CCSB-HI1-union-LC.44 Size of complex: 8 Interactions within complex: 3183 3183 3183 51545 3480 3480 3480 4734 4734 9802 9802 9802 9802 23543 9802 51545 9802 54472 9802 84528 23543 84528 54472 84528 84528 84528 =============================================================================== Complex CCSB-HI1-union-LC.86 Size of complex: 3 Interactions within complex: 10241 10241 10241 79797 55145 55145 55145 79797 79797 79797