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["© 2000-2016 QIAGEN. All rights reserved."]
["Categories","Diseases or Functions Annotation","p-Value","Predicted Activation State","Activation z-score","Notes","Molecules","# Molecules"]
["Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development","development of neuroepithelial cells","2.06E-05"," "," "," ","ID1,SHH","2"]
["Behavior","cognition","2.56E-05","Increased","2.199","bias","ARHGEF9,ARSG,CAMK2A,GABBR1,KL,NRXN1,PLP1,SRR","8"]
["Molecular Transport","import of Cu2+","6.85E-05"," "," "," ","SLC31A1,STEAP2","2"]
["Molecular Transport","transport of ion","1.02E-04"," "," "," ","AQP1,CAMK2A,KCNE2,SLC31A1,STEAP2,TRPM3","6"]
["Neurological Disease, Organismal Injury and Abnormalities","microgliosis","1.49E-04"," "," "," ","ARSG,IDE,PLP1","3"]
["Organismal Development","size of animal","1.74E-04"," ","1.342","bias","GABBR1,ID1,IGF2BP1,KL,SHH","5"]
["Organismal Survival","organismal death","2.20E-04","Decreased","-3.124","bias","ACE,AQP1,E2F5,ENPP2,F5,FOLR1,GABBR1,ID1,IDE,IGF2BP1,KL,KLF2,NRXN1,PLP1,SHH,SLC31A1,SOSTDC1,UCP2,UPF2","19"]
["Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities, Reproductive System Disease","pituitary gland adenoma","2.94E-04"," "," "," ","ALDH2,FOLR1,ID1,PRLR","4"]
["Connective Tissue Development and Function, Skeletal and Muscular System Development and Function","bone mineral density of tibia","3.05E-04"," "," "," ","GABBR1,PRLR","2"]
["Molecular Transport","transport of cation","3.47E-04"," "," "," ","AQP1,CAMK2A,SLC31A1,STEAP2,TRPM3","5"]
["Embryonic Development, Organismal Development","development of body trunk","4.63E-04"," ","0.577","bias","ACE,Ap2b1,AQP1,F5,FOLR1,ID1,IGF2BP1,KL,KLF2,PRLR,SHH,UPF2","12"]
["Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development","proliferation of neuronal cells","4.79E-04"," ","1.667","bias","CAMK2A,ENPP2,ID1,MID1,PRLR,SHH","6"]
["Neurological Disease, Organismal Injury and Abnormalities","gliosis","4.85E-04"," ","-1.988","bias","ARSG,IDE,PLP1,PRLR","4"]
["Cancer, Organismal Injury and Abnormalities","head and neck neoplasia","5.27E-04"," "," "," ","ALDH2,FOLR1,ID1,PRLR,SHH","5"]
["Cancer, Organismal Injury and Abnormalities","incidence of head and neck tumor","6.80E-04"," "," "," ","ID1,PRLR,SHH","3"]
["Immunological Disease","onset of autoimmune disease","7.07E-04"," "," "," ","PLP1,UCP2","2"]
["Protein Synthesis","quantity of PRL in blood","7.07E-04"," "," "," ","GABBR1,PRLR","2"]
["Developmental Disorder","Growth Failure","7.50E-04","Decreased","-2.204","bias","AQP1,ENPP2,FOLR1,ID1,IGF2BP1,KL,KLF2,SHH","8"]
["Behavior","emotional behavior","8.48E-04"," "," "," ","CAMK2A,GABBR1,NRXN1,PRLR,TRPM3","5"]
["Nervous System Development and Function","abnormal morphology of nervous system","8.56E-04"," "," "," ","ARHGEF9,ARSG,CAMK2A,E2F5,GABBR1,ID1,PLP1,SHH,SOSTDC1","9"]
["Cell-To-Cell Signaling and Interaction, Nervous System Development and Function","long-term potentiation of synapse","8.64E-04"," ","1.103","bias","ARHGEF9,CAMK2A,GABBR1,SRR","4"]
["Organismal Survival","survival of organism","8.67E-04"," ","1.446"," ","AQP1,ID1,IDE,KL,SHH,SLC31A1,SOSTDC1,UCP2","8"]
["Behavior","learning","1.08E-03"," "," "," ","ARHGEF9,ARSG,CAMK2A,GABBR1,NRXN1,SRR","6"]
["Cell-To-Cell Signaling and Interaction, Nervous System Development and Function","excitatory postsynaptic current","1.11E-03"," "," "," ","GABBR1,NRXN1,SRR","3"]
["Endocrine System Disorders, Metabolic Disease","hyperglycemia","1.33E-03"," "," "," ","ACE,PRLR,STEAP2,UCP2","4"]
["Neurological Disease, Organismal Injury and Abnormalities","astrocytosis","1.34E-03"," "," "," ","ARSG,IDE,PLP1","3"]
["Cardiovascular System Development and Function, Tissue Morphology","permeability of blood vessel","1.34E-03"," "," "," ","AQP1,ID1,KL","3"]
["Visual System Development and Function","photoresponse","1.40E-03"," "," "," ","PRLR,RDH5","2"]
["Molecular Transport","quantity of metal","1.47E-03"," ","0.218"," ","ACE,AQP1,KL,PRLR,SLC31A1","5"]
["Molecular Transport","transport of metal ion","1.47E-03"," "," "," ","AQP1,CAMK2A,SLC31A1,STEAP2","4"]
["Cell Morphology, Nervous System Development and Function, Tissue Morphology","abnormal morphology of neurons","1.52E-03"," "," "," ","ARHGEF9,ARSG,CAMK2A,GABBR1,PLP1,SHH","6"]
["Organismal Injury and Abnormalities, Tissue Morphology","permeability of epithelial tissue","1.54E-03"," "," "," ","AQP1,KL","2"]
["Free Radical Scavenging, Molecular Transport","quantity of superoxide","1.68E-03"," "," "," ","CAMK2A,UCP2","2"]
["Developmental Disorder, Organismal Injury and Abnormalities, Renal and Urological Disease","congenital anomalies of kidney and urinary tract","1.69E-03"," "," "," ","ACE,KL,SHH","3"]
["Connective Tissue Development and Function, Skeletal and Muscular System Development and Function","bone mineral density","1.72E-03"," ","1.969","bias","GABBR1,ID1,KL,PRLR","4"]
["Cell Morphology, Hematological System Development and Function, Inflammatory Response, Nervous System Development and Function","abnormal morphology of microglia","1.83E-03"," "," "," ","ARSG,PLP1","2"]
["Cellular Function and Maintenance","cellular homeostasis","2.41E-03"," ","0.282","bias","AQP1,F5,ID1,KCNE2,KL,KLF2,PLP1,SHH,SLC31A1,UCP2","10"]
["Connective Tissue Development and Function, Skeletal and Muscular System Development and Function","bone mineral density of femur","2.49E-03"," "," "," ","GABBR1,PRLR","2"]
["Cellular Development, Cellular Growth and Proliferation, Tissue Development","development of epithelial cells","2.64E-03"," "," "," ","ID1,PRLR,SHH","3"]
["Molecular Transport","transport of divalent cations","2.64E-03"," "," "," ","CAMK2A,SLC31A1,STEAP2","3"]
["Auditory and Vestibular System Development and Function, Organ Morphology, Organismal Development, Tissue Morphology","abnormal morphology of otic pit","2.65E-03"," "," "," ","FOLR1","1"]
["Organ Morphology","abnormal morphology of papillary layer","2.65E-03"," "," "," ","SHH","1"]
["Cardiovascular System Development and Function, Organ Morphology, Organismal Development, Renal and Urological System Development and Function, Tissue Morphology","abnormal morphology of renal artery","2.65E-03"," "," "," ","ACE","1"]
["Drug Metabolism, Molecular Transport, Small Molecule Biochemistry","accumulation of carboplatin","2.65E-03"," "," "," ","SLC31A1","1"]
["Drug Metabolism, Molecular Transport","accumulation of cisplatin","2.65E-03"," "," "," ","SLC31A1","1"]
["Free Radical Scavenging, Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry","accumulation of lipid peroxide","2.65E-03"," "," "," ","KL","1"]
["Amino Acid Metabolism, Drug Metabolism, Lipid Metabolism, Small Molecule Biochemistry","binding of baclofen","2.65E-03"," "," "," ","GABBR1","1"]
["Cell Morphology, Cellular Development, Cellular Growth and Proliferation, Embryonic Development, Tissue Development","branching of duct cells","2.65E-03"," "," "," ","PRLR","1"]
["Renal and Urological System Development and Function","concentration of urine","2.65E-03"," "," "," ","ACE","1"]
["Small Molecule Biochemistry","conversion of sulfate","2.65E-03"," "," "," ","SRR","1"]
["Cell Death and Survival, Cellular Compromise, Neurological Disease, Tissue Morphology","degeneration of GABAergic neurons","2.65E-03"," "," "," ","SHH","1"]
["Connective Tissue Development and Function, Skeletal and Muscular System Development and Function, Tissue Development","delay in initiation of calcification of digit","2.65E-03"," "," "," ","GABBR1","1"]
["Connective Tissue Development and Function, Skeletal and Muscular System Development and Function, Tissue Development","delay in initiation of calcification of hyoid bone","2.65E-03"," "," "," ","GABBR1","1"]
["Connective Tissue Development and Function, Skeletal and Muscular System Development and Function, Tissue Development","delay in initiation of calcification of metatarsal bone","2.65E-03"," "," "," ","GABBR1","1"]
["Cellular Development, Cellular Growth and Proliferation, Embryonic Development, Organismal Development, Tissue Development","development of cardiopulmonary mesoderm progenitor cells","2.65E-03"," "," "," ","SHH","1"]
["Digestive System Development and Function, Embryonic Development, Organ Development, Organismal Development, Tissue Development","development of dental cord","2.65E-03"," "," "," ","SHH","1"]
["Embryonic Development, Organismal Development, Tissue Development","development of telencephalic vesicle","2.65E-03"," "," "," ","SHH","1"]
["Auditory and Vestibular System Development and Function, Nervous System Development and Function","development of vestibulocochlear cranial nerve ganglion","2.65E-03"," "," "," ","SHH","1"]
["Cellular Function and Maintenance, Molecular Transport","efflux of iodide","2.65E-03"," "," "," ","KCNE2","1"]
["Cell Cycle","entry into S/G2 phase transition of T lymphocytes","2.65E-03"," "," "," ","SHH","1"]
["Embryonic Development, Hair and Skin Development and Function, Organ Development, Organismal Development, Tissue Development","formation of dermal papilla","2.65E-03"," "," "," ","SHH","1"]
["Embryonic Development, Organismal Development, Tissue Development","formation of genital tubercle","2.65E-03"," "," "," ","SHH","1"]
["Cellular Development, Cellular Growth and Proliferation, Embryonic Development, Organ Development, Organismal Development, Reproductive System Development and Function, Tissue Development","formation of lobulo-alveolar bud cells","2.65E-03"," "," "," ","PRLR","1"]
["Cell Death and Survival, DNA Replication, Recombination, and Repair","fragmentation of mitochondrial DNA","2.65E-03"," "," "," ","KL","1"]
["Organ Development, Reproductive System Development and Function","function of oviduct","2.65E-03"," "," "," ","PRLR","1"]
["Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development","generation of cholinergic neurons","2.65E-03"," "," "," ","SHH","1"]
["Nervous System Development and Function, Organ Development","growth of mesencephalon","2.65E-03"," "," "," ","SHH","1"]
["Gastrointestinal Disease","hypergastrinemia of gastric gland","2.65E-03"," "," "," ","KCNE2","1"]
["Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities","hyperplasia of Th2 cells","2.65E-03"," "," "," ","PLP1","1"]
["Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities","hyperplasia of gastric gland","2.65E-03"," "," "," ","KCNE2","1"]
["Cardiovascular Disease","hypocellularity of atrioventricular canal cushion","2.65E-03"," "," "," ","KLF2","1"]
["Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities","incidence of medullary thyroid carcinoma","2.65E-03"," "," "," ","PRLR","1"]
["Cell-To-Cell Signaling and Interaction, Cellular Growth and Proliferation, Nervous System Development and Function","induction of oligodendrocytes","2.65E-03"," "," "," ","SHH","1"]
["Immunological Disease, Inflammatory Disease, Inflammatory Response, Neurological Disease","initiation of experimental autoimmune encephalomyelitis","2.65E-03"," "," "," ","PLP1","1"]
["Organ Morphology","lack of inner root sheath","2.65E-03"," "," "," ","SHH","1"]
["Cardiovascular System Development and Function, Tissue Morphology","morphology of umbilical vein","2.65E-03"," "," "," ","KLF2","1"]
["Cell Death and Survival, Skeletal and Muscular Disorders","necrosis of limb","2.65E-03"," "," "," ","SHH","1"]
["Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development","neurogenesis of neuroepithelial cells","2.65E-03"," "," "," ","ID1","1"]
["Cardiovascular System Development and Function","organization of tunica media","2.65E-03"," "," "," ","KLF2","1"]
["Cardiovascular System Development and Function, Embryonic Development, Organ Development, Organismal Development, Tissue Development","organogenesis of heart","2.65E-03"," "," "," ","SHH","1"]
["Energy Production, Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism","oxidation of 9-cis-retinal","2.65E-03"," "," "," ","RDH5","1"]
["Nervous System Development and Function, Tissue Morphology","quantity of astrocyte precursor cells","2.65E-03"," "," "," ","SHH","1"]
["Amino Acid Metabolism, Post-Translational Modification, Small Molecule Biochemistry","racemization of L-serine","2.65E-03"," "," "," ","SRR","1"]
["Carbohydrate Metabolism, Energy Production","release of pyruvic acid","2.65E-03"," "," "," ","SRR","1"]
["Molecular Transport","secretion of H+","2.65E-03"," "," "," ","KCNE2","1"]
["Organismal Development, Reproductive System Development and Function","secretion of breast milk","2.65E-03"," "," "," ","PRLR","1"]
["Cell Cycle","senescence of oligodendrocyte precursor cells","2.65E-03"," "," "," ","C2orf40","1"]
["Cell Cycle","senescence of progenitor cells","2.65E-03"," "," "," ","KL","1"]
["Cell Morphology","size of leukemia cell lines","2.65E-03"," "," "," ","KLF2","1"]
["Cell Morphology, Cellular Assembly and Organization, Nervous System Development and Function","structure of myelin sheath","2.65E-03"," "," "," ","PLP1","1"]
["Amino Acid Metabolism, Small Molecule Biochemistry","synthesis of D-serine","2.65E-03"," "," "," ","SRR","1"]
["Molecular Transport","translocation of water","2.65E-03"," "," "," ","AQP1","1"]
["Cell Morphology, Cellular Development, Embryonic Development, Organismal Development","ventralization of embryonic stem cells","2.65E-03"," "," "," ","SHH","1"]
["Tissue Morphology","abnormal morphology of extraembryonic tissue","2.67E-03"," "," "," ","ENPP2,F5,KLF2,SHH","4"]
["Hair and Skin Development and Function, Organ Morphology","abnormal morphology of hair","2.71E-03"," "," "," ","E2F5,PRLR,SHH","3"]
["Endocrine System Disorders, Metabolic Disease","impaired glucose tolerance","2.71E-03"," "," "," ","IDE,PRLR,STEAP2","3"]
["Cell Cycle","re-entry into cell cycle progression","2.85E-03"," "," "," ","E2F5,ID1","2"]
["Digestive System Development and Function","morphology of digestive system","3.00E-03"," "," "," ","ARSG,FOLR1,IGF2BP1,KCNE2,PRLR,SHH,SOSTDC1","7"]
["Cancer, Organismal Injury and Abnormalities","head and neck cancer","3.09E-03"," "," "," ","ID1,PRLR,SHH","3"]
["Metabolic Disease","hypothermia","3.24E-03"," "," "," ","GABBR1,KLF2","2"]
["Embryonic Development, Tissue Morphology","abnormal morphology of yolk sac","3.34E-03"," "," "," ","F5,KLF2,SHH","3"]
["Embryonic Development, Organ Development, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development","formation of smooth muscle","3.45E-03"," "," "," ","KLF2,SHH","2"]
["Cancer, Organismal Injury and Abnormalities","incidence of tumor","3.66E-03"," ","-1.387","bias","FOLR1,ID1,IGF2BP1,PRLR,SHH","5"]
["Cardiovascular Disease","Hypotension","3.66E-03"," "," "," ","ACE,KLF2","2"]
["Cell Death and Survival, Neurological Disease","cell death of hippocampal cells","3.66E-03"," "," "," ","KL,UCP2","2"]
["Cell Death and Survival, Neurological Disease","cell death of cerebral cortex cells","3.86E-03"," "," "," ","KL,SRR,UCP2","3"]
["Tissue Development","morphogenesis of epithelial tissue","3.86E-03"," "," "," ","ID1,PRLR,SHH","3"]
["Cell Morphology, Nervous System Development and Function, Tissue Morphology","abnormal morphology of myelin sheath","3.87E-03"," "," "," ","GABBR1,PLP1","2"]
["Cell Morphology","conversion of cells","3.87E-03"," "," "," ","PRLR,SHH","2"]
["Embryonic Development, Hair and Skin Development and Function, Organ Development, Organ Morphology, Organismal Development, Tissue Development","morphogenesis of hair follicle","3.87E-03"," "," "," ","SHH,SOSTDC1","2"]
["Organismal Functions","movement of rodents","3.99E-03"," "," "," ","ARHGEF9,KL,PLP1,SRR","4"]
["Cellular Movement, Embryonic Development","migration of neural crest cells","4.32E-03"," "," "," ","FOLR1,SHH","2"]
["Cell-To-Cell Signaling and Interaction, Nervous System Development and Function","excitatory postsynaptic potential","4.43E-03"," "," "," ","ARHGEF9,CAMK2A,NRXN1","3"]
["Behavior","behavior","4.51E-03"," ","1.577"," ","ARHGEF9,ARSG,CAMK2A,GABBR1,NRXN1,PRLR,SHH,SRR,TRPM3","9"]
["Molecular Transport","quantity of metal ion","4.54E-03"," "," "," ","ACE,AQP1,KL,PRLR","4"]
["Cell-mediated Immune Response, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Hematological System Development and Function, Hematopoiesis, Lymphoid Tissue Structure and Development, Tissue Development","differentiation of regulatory T lymphocytes","4.79E-03"," "," "," ","ID1,PLP1","2"]
["Behavior, Nervous System Development and Function","passive avoidance learning","4.79E-03"," "," "," ","ARSG,GABBR1","2"]
["Nervous System Development and Function","nociception","4.84E-03"," "," "," ","AQP1,GABBR1,TRPM3","3"]
["Cell-To-Cell Signaling and Interaction","synaptic depression","4.84E-03"," "," "," ","ARHGEF9,CAMK2A,NRXN1","3"]
["Cardiovascular System Development and Function, Organismal Development","development of aorta","5.28E-03"," "," "," ","Ap2b1,SHH","2"]
["Embryonic Development, Organ Development, Organ Morphology, Organismal Development, Respiratory System Development and Function, Tissue Development","morphogenesis of lung","5.28E-03"," "," "," ","ID1,SHH","2"]
["Organ Morphology, Organismal Development","abnormal morphology of Harderian gland","5.29E-03"," "," "," ","PRLR","1"]
["Organ Morphology, Organismal Development, Renal and Urological System Development and Function","abnormal morphology of medullary ray","5.29E-03"," "," "," ","ACE","1"]
["Organ Morphology, Respiratory System Development and Function, Skeletal and Muscular System Development and Function","abnormal morphology of trachealis muscle","5.29E-03"," "," "," ","SHH","1"]
["Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry, Vitamin and Mineral Metabolism","accumulation of 11-cis-retinyl esters","5.29E-03"," "," "," ","RDH5","1"]
["Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry, Vitamin and Mineral Metabolism","accumulation of 13-cis-retinyl esters","5.29E-03"," "," "," ","RDH5","1"]
["Organismal Development","accumulation of urine","5.29E-03"," "," "," ","AQP1","1"]
["Connective Tissue Disorders, Dental Disease, Developmental Disorder, Digestive System Development and Function, Gastrointestinal Disease, Organismal Development, Skeletal and Muscular Disorders","agenesis of premaxillary incisor","5.29E-03"," "," "," ","SHH","1"]
["Cell Death and Survival, Cellular Function and Maintenance","clearance of Leishmania donovani strain AG83","5.29E-03"," "," "," ","UCP2","1"]
["Cellular Development, Cellular Growth and Proliferation, Hematological System Development and Function, Hematopoiesis, Humoral Immune Response","clonal expansion of pre-B lymphocytes","5.29E-03"," "," "," ","KLF2","1"]
["Carbohydrate Metabolism, Energy Production","conversion of pyruvic acid","5.29E-03"," "," "," ","SRR","1"]
["Lipid Metabolism, Small Molecule Biochemistry","damage of lipid","5.29E-03"," "," "," ","UCP2","1"]
["Connective Tissue Development and Function, Skeletal and Muscular System Development and Function","delay in resorption of trabecular bone","5.29E-03"," "," "," ","KL","1"]
["Endocrine System Development and Function, Organ Morphology","density of islets of Langerhans","5.29E-03"," "," "," ","PRLR","1"]
["Digestive System Development and Function, Embryonic Development, Organ Development, Organismal Development, Tissue Development","development of duodenum","5.29E-03"," "," "," ","SHH","1"]
["Embryonic Development, Organismal Development, Tissue Development","development of head fold","5.29E-03"," "," "," ","ENPP2","1"]
["Cellular Development, Cellular Growth and Proliferation, Connective Tissue Development and Function, Digestive System Development and Function, Embryonic Development, Organ Development, Organismal Development, Tissue Development","development of interstitial cells of cajal","5.29E-03"," "," "," ","SHH","1"]
["Connective Tissue Development and Function, Embryonic Development, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development","development of neurocranial base","5.29E-03"," "," "," ","SHH","1"]
["Embryonic Development, Organ Development, Organismal Development, Respiratory System Development and Function, Tissue Development","development of nostril","5.29E-03"," "," "," ","SHH","1"]
["Auditory and Vestibular System Development and Function, Embryonic Development, Organ Development, Organismal Development, Tissue Development","development of preotic pillar","5.29E-03"," "," "," ","SHH","1"]
["Cell Morphology, Cellular Assembly and Organization, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development","development of retinal axons","5.29E-03"," "," "," ","SHH","1"]
["Digestive System Development and Function, Lipid Metabolism, Small Molecule Biochemistry","digestion of lipid","5.29E-03"," "," "," ","AQP1","1"]
["Connective Tissue Development and Function, Embryonic Development, Organ Development, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development","formation of ectotympanic bone","5.29E-03"," "," "," ","SHH","1"]
["Connective Tissue Development and Function, Embryonic Development, Organ Development, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development","formation of gonial bone","5.29E-03"," "," "," ","SHH","1"]
["Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities, Reproductive System Disease","formation of prolactinoma","5.29E-03"," "," "," ","PRLR","1"]
["Neurological Disease","head tremor","5.29E-03"," "," "," ","PLP1","1"]
["Cancer, Organismal Injury and Abnormalities","hyperplasia of progenitor cells","5.29E-03"," "," "," ","SHH","1"]
["Connective Tissue Development and Function, Organ Morphology, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development","lack of tibia","5.29E-03"," "," "," ","SHH","1"]
["Auditory and Vestibular System Development and Function, Organ Morphology, Organismal Development","lack of utricle","5.29E-03"," "," "," ","SHH","1"]
["Cellular Function and Maintenance, Cellular Movement, Embryonic Development","localization of neural crest cells","5.29E-03"," "," "," ","SHH","1"]
["Connective Tissue Disorders, Skeletal and Muscular Disorders, Tissue Morphology","loss of coronal suture","5.29E-03"," "," "," ","SHH","1"]
["Amino Acid Metabolism, Small Molecule Biochemistry","metabolism of L-serine","5.29E-03"," "," "," ","SRR","1"]
["Amino Acid Metabolism, Drug Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism","metabolism of folic acid","5.29E-03"," "," "," ","FOLR1","1"]
["Cancer, Organismal Injury and Abnormalities","metastasis of fibroblast cell lines","5.29E-03"," "," "," ","ENPP2","1"]
["Cellular Movement, Hematological System Development and Function, Humoral Immune Response, Immune Cell Trafficking","migration of pre-B lymphocytes","5.29E-03"," "," "," ","KLF2","1"]
["Nervous System Development and Function, Organ Morphology, Organismal Development","morphology of brain septum","5.29E-03"," "," "," ","SHH","1"]
["Cardiovascular System Development and Function, Cell Morphology, Hematological System Development and Function, Hematopoiesis, Tissue Morphology","morphology of erythroid cells","5.29E-03"," "," "," ","KLF2","1"]
["Embryonic Development, Organ Development, Organismal Development, Renal and Urological System Development and Function, Tissue Development","organogenesis of kidney","5.29E-03"," "," "," ","SHH","1"]
["Cell Morphology","osmotic water permeability of red blood cells","5.29E-03"," "," "," ","AQP1","1"]
["Embryonic Development, Organ Development, Organismal Development, Reproductive System Development and Function, Tissue Development","outgrowth of mammary lobuloalveolar unit","5.29E-03"," "," "," ","PRLR","1"]
["Energy Production, Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism","oxidation of 9-cis-retinol","5.29E-03"," "," "," ","RDH5","1"]
["Carbohydrate Metabolism, Energy Production","production of pyruvic acid","5.29E-03"," "," "," ","SRR","1"]
["Connective Tissue Development and Function, Organ Development, Skeletal and Muscular System Development and Function","remodeling of squamosal bone","5.29E-03"," "," "," ","SHH","1"]
["Hair and Skin Development and Function","self-renewal of epidermis","5.29E-03"," "," "," ","SHH","1"]
["Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry","sequestration of cholesterol","5.29E-03"," "," "," ","PLP1","1"]
["Digestive System Development and Function, Organ Morphology","size of crypt","5.29E-03"," "," "," ","FOLR1","1"]
["Digestive System Development and Function, Organismal Development","size of tooth","5.29E-03"," "," "," ","SHH","1"]
["Cardiovascular System Development and Function","stabilization of blood vessel","5.29E-03"," "," "," ","KLF2","1"]
["Cellular Assembly and Organization, Nervous System Development and Function","stabilization of myelin sheath","5.29E-03"," "," "," ","PLP1","1"]
["Gastrointestinal Disease, Organismal Injury and Abnormalities","stenosis of esophagus","5.29E-03"," "," "," ","SHH","1"]
["Cell Death and Survival, Organismal Survival","survival of Leishmania donovani strain AG83","5.29E-03"," "," "," ","UCP2","1"]
["Cell Death and Survival, Hematological Disease, Hematological System Development and Function, Immunological Disease","survival of germinal center B lymphocytes","5.29E-03"," "," "," ","SHH","1"]
["Inflammatory Disease, Inflammatory Response, Ophthalmic Disease, Organismal Injury and Abnormalities","swelling of cornea","5.29E-03"," "," "," ","AQP1","1"]
["Cell-To-Cell Signaling and Interaction, Nervous System Development and Function","synaptic plasticity of collateral synapses","5.29E-03"," "," "," ","SRR","1"]
["Connective Tissue Disorders, Gastrointestinal Disease, Skeletal and Muscular Disorders","synostosis of mandible","5.29E-03"," "," "," ","SHH","1"]
["Connective Tissue Disorders, Gastrointestinal Disease, Skeletal and Muscular Disorders","synostosis of premaxilla","5.29E-03"," "," "," ","SHH","1"]
["Connective Tissue Disorders, Skeletal and Muscular Disorders","synostosis of symphysis","5.29E-03"," "," "," ","SHH","1"]
["Nucleic Acid Metabolism, Small Molecule Biochemistry","synthesis of NADPH","5.29E-03"," "," "," ","ALDH2","1"]
["Organismal Injury and Abnormalities, Tissue Morphology","size of lesion","5.70E-03"," "," "," ","CAMK2A,F5,SRR,UCP2","4"]
["Cancer, Organismal Injury and Abnormalities","tumorigenesis of head and neck tumor","5.80E-03"," "," "," ","PRLR,SHH","2"]
["Organ Morphology, Organismal Development, Renal and Urological System Development and Function","abnormal morphology of kidney","5.84E-03"," "," "," ","ACE,ARSG,KL,SHH","4"]
["Cell Cycle","senescence of cells","6.31E-03"," "," "," ","C2orf40,ID1,KL","3"]
["Cellular Function and Maintenance, Small Molecule Biochemistry","homeostasis of anion","6.34E-03"," "," "," ","KCNE2,KL","2"]
["Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities","hyperplasia of gastrointestinal tract","6.34E-03"," "," "," ","KCNE2,SHH","2"]
["Cell Morphology, Connective Tissue Development and Function, Tissue Morphology","size of connective tissue cells","6.43E-03"," "," "," ","ENPP2,ID1,KL","3"]
["Embryonic Development, Organ Development, Organismal Development, Renal and Urological System Development and Function, Tissue Development","formation of kidney","6.54E-03"," ","0.339","bias","ACE,AQP1,KL,SHH","4"]
["Cellular Development","differentiation of brain cells","6.61E-03"," "," "," ","ID1,SHH","2"]
["Neurological Disease","epilepsy","6.61E-03"," "," "," ","DBP,GABBR1","2"]
["Behavior, Nervous System Development and Function","long-term memory","6.61E-03"," "," "," ","CAMK2A,GABBR1","2"]
["Cell-mediated Immune Response, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Hematological System Development and Function, Hematopoiesis, Lymphoid Tissue Structure and Development, Tissue Development","development of regulatory T lymphocytes","6.89E-03"," "," "," ","ID1,KLF2","2"]
["Tissue Morphology","lack of vitelline vessel","6.89E-03"," "," "," ","ENPP2,SHH","2"]
["Vitamin and Mineral Metabolism","metabolism of vitamin","7.48E-03"," "," "," ","FOLR1,RDH5","2"]
["Renal and Urological System Development and Function","osmolality of urine","7.48E-03"," "," "," ","ACE,AQP1","2"]
["Hematological System Development and Function","circulation of blood","7.77E-03"," "," "," ","ENPP2,F5","2"]
["Neurological Disease, Organismal Injury and Abnormalities","hyperalgesia","7.77E-03"," "," "," ","CAMK2A,GABBR1","2"]
["Developmental Disorder, Organismal Injury and Abnormalities, Renal and Urological Disease","hypoplasia of kidney","7.77E-03"," "," "," ","ACE,KL","2"]
["Molecular Transport","transport of molecule","7.79E-03"," "," "," ","AQP1,CAMK2A,KCNE2,NRXN1,SHH,SLC31A1,STEAP2,TRPM3","8"]
["Hair and Skin Development and Function, Organ Morphology","abnormal morphology of coarse hair","7.93E-03"," "," "," ","PRLR","1"]
["Cellular Assembly and Organization","aggregation of pigment granules","7.93E-03"," "," "," ","GABBR1","1"]
["Cardiovascular Disease, Hematological Disease, Organismal Injury and Abnormalities","aplastic anemia","7.93E-03"," "," "," ","ALDH2","1"]
["Embryonic Development, Hair and Skin Development and Function, Organ Development, Organismal Development, Tissue Development","arrest in development of hair follicle","7.93E-03"," "," "," ","SHH","1"]
["Gastrointestinal Disease, Organismal Injury and Abnormalities","atrophy of intestine","7.93E-03"," "," "," ","KL","1"]
["Connective Tissue Disorders, Developmental Disorder, Gastrointestinal Disease, Organismal Development, Skeletal and Muscular Disorders","cleft palate syndrome of secondary palate","7.93E-03"," "," "," ","SHH","1"]
["Developmental Disorder, Neurological Disease, Organismal Injury and Abnormalities","congenital hydrocephalus","7.93E-03"," "," "," ","E2F5","1"]
["Embryonic Development, Organismal Development, Tissue Development","development of genital tubercle","7.93E-03"," "," "," ","SHH","1"]
["Auditory and Vestibular System Development and Function, Connective Tissue Development and Function, Embryonic Development, Organ Development, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development","development of incus","7.93E-03"," "," "," ","SHH","1"]
["Cell-mediated Immune Response, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Hematological System Development and Function, Hematopoiesis, Lymphoid Tissue Structure and Development, Tissue Development","development of induced regulatory T-lymphocyte","7.93E-03"," "," "," ","KLF2","1"]
["Digestive System Development and Function, Embryonic Development, Organ Development, Organismal Development, Tissue Development","development of rectum","7.93E-03"," "," "," ","SHH","1"]
["Auditory and Vestibular System Development and Function, Connective Tissue Development and Function, Embryonic Development, Organ Development, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development","development of stapes","7.93E-03"," "," "," ","SHH","1"]
["Skeletal and Muscular System Development and Function","development of symphysis","7.93E-03"," "," "," ","SHH","1"]
["Cell-mediated Immune Response, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Hematological System Development and Function, Hematopoiesis, Lymphoid Tissue Structure and Development, Tissue Development","differentiation of Th2-like cells","7.93E-03"," "," "," ","SHH","1"]
["Cellular Development, Endocrine System Development and Function","differentiation of gonadotropes","7.93E-03"," "," "," ","SHH","1"]
["Cellular Development, Endocrine System Development and Function","differentiation of thyrotropes","7.93E-03"," "," "," ","SHH","1"]
["Cellular Development, Cellular Growth and Proliferation, Hematological System Development and Function","expansion of gamma-delta natural killer T lymphocytes","7.93E-03"," "," "," ","KLF2","1"]
["Organismal Injury and Abnormalities, Reproductive System Disease","experimentally-induced adenomyosis","7.93E-03"," "," "," ","PRLR","1"]
["Cellular Development, Cellular Growth and Proliferation, Embryonic Development, Organ Development, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development","formation of smooth muscle cells","7.93E-03"," "," "," ","KLF2","1"]
["Endocrine System Disorders, Organismal Injury and Abnormalities, Reproductive System Disease","hyperprolactinemia","7.93E-03"," "," "," ","PRLR","1"]
["Connective Tissue Disorders, Inflammatory Response, Tissue Development","inflammation of visceral fat","7.93E-03"," "," "," ","STEAP2","1"]
["Inflammatory Response","inflammatory response of fibroblast cell lines","7.93E-03"," "," "," ","STEAP2","1"]
["Connective Tissue Development and Function, Organ Morphology, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development","lack of fibula","7.93E-03"," "," "," ","SHH","1"]
["Embryonic Development, Tissue Morphology","lack of first branchial arch","7.93E-03"," "," "," ","FOLR1","1"]
["Organismal Development, Skeletal and Muscular System Development and Function","lack of forelimb","7.93E-03"," "," "," ","SHH","1"]
["Connective Tissue Development and Function, Skeletal and Muscular System Development and Function, Tissue Morphology","lack of tracheal ring","7.93E-03"," "," "," ","SHH","1"]
["Embryonic Development, Tissue Morphology","length of proliferative zone","7.93E-03"," "," "," ","KL","1"]
["Cell-To-Cell Signaling and Interaction, Nervous System Development and Function","long-term potentiation of barrel cortex","7.93E-03"," "," "," ","CAMK2A","1"]
["Connective Tissue Development and Function, Tissue Morphology","mass of perirenal white adipose tissue","7.93E-03"," "," "," ","ENPP2","1"]
["Cellular Development, Nervous System Development and Function, Tissue Development","maturation of neuronal progenitor cells","7.93E-03"," "," "," ","SHH","1"]
["Lipid Metabolism, Small Molecule Biochemistry","metabolism of oleic acid","7.93E-03"," "," "," ","DBP","1"]
["Lipid Metabolism, Small Molecule Biochemistry","metabolism of stearic acid","7.93E-03"," "," "," ","DBP","1"]
["Developmental Disorder, Gastrointestinal Disease","metaplasia of stomach","7.93E-03"," "," "," ","SHH","1"]
["Cell-To-Cell Signaling and Interaction, Cellular Assembly and Organization, Cellular Function and Maintenance, Inflammatory Response","phagocytosis of photoreceptor outer segments","7.93E-03"," "," "," ","KL","1"]
["Cell Morphology","polarization of naive T lymphocytes","7.93E-03"," "," "," ","ENPP2","1"]
["Cellular Assembly and Organization","proliferation of mitochondria","7.93E-03"," "," "," ","UCP2","1"]
["Amino Acid Metabolism, Drug Metabolism, Molecular Transport, Small Molecule Biochemistry, Vitamin and Mineral Metabolism","quantity of folic acid","7.93E-03"," "," "," ","FOLR1","1"]
["Organismal Development","relaxation of mice","7.93E-03"," "," "," ","GABBR1","1"]
["Cell Cycle, Cellular Development, Respiratory System Development and Function","senescence of lung cell lines","7.93E-03"," "," "," ","ID1","1"]
["Hair and Skin Development and Function, Organ Morphology","size of hair follicle","7.93E-03"," "," "," ","SHH","1"]
["Cell Death and Survival, Nervous System Development and Function","survival of oligodendrocytes","7.93E-03"," "," "," ","PLP1","1"]
["Embryonic Development, Organismal Development","development of abdomen","7.99E-03"," ","0.339","bias","ACE,AQP1,IGF2BP1,KL,SHH,UPF2","6"]
["Psychological Disorders","hyperactive behavior","8.03E-03"," "," "," ","CAMK2A,GABBR1,SRR","3"]
["Digestive System Development and Function, Embryonic Development, Organ Development, Organismal Development, Tissue Development","development of intestine","8.08E-03"," "," "," ","IGF2BP1,SHH","2"]
["Cellular Development, Cellular Growth and Proliferation, Embryonic Development, Nervous System Development and Function, Organismal Development, Tissue Development","proliferation of neuroblasts","8.08E-03"," "," "," ","ID1,SHH","2"]
["Cell-mediated Immune Response, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Hematological System Development and Function, Hematopoiesis, Lymphoid Tissue Structure and Development, Tissue Development","differentiation of thymocytes","8.39E-03"," "," "," ","ID1,SHH","2"]
["Cell-To-Cell Signaling and Interaction, Nervous System Development and Function","inhibitory postsynaptic current","8.39E-03"," "," "," ","ARHGEF9,GABBR1","2"]
["Cellular Development, Nervous System Development and Function, Tissue Development","maturation of neurons","8.70E-03"," "," "," ","CAMK2A,SHH","2"]
["Cellular Development, Embryonic Development, Organismal Development, Tissue Development","differentiation of embryonic tissue","8.76E-03"," "," "," ","FOLR1,ID1,SHH","3"]
["Cellular Development, Cellular Growth and Proliferation, Connective Tissue Development and Function, Tissue Development","proliferation of chondrocytes","9.02E-03"," "," "," ","GABBR1,KL","2"]
["Cellular Function and Maintenance, Small Molecule Biochemistry","homeostasis of ion","9.06E-03"," "," "," ","KCNE2,KL,SLC31A1","3"]
["Respiratory Disease","abnormal respiration","9.34E-03"," "," "," ","ALDH2,UCP2","2"]
["Digestive System Development and Function","abnormal morphology of digestive system","9.94E-03"," "," "," ","ARSG,FOLR1,KCNE2,PRLR,SHH,SOSTDC1","6"]
["Organismal Development","growth of organism","9.96E-03"," ","0.968","bias","AQP1,ID1,IGF2BP1,KLF2,SHH,SLC31A1,UCP2","7"]
["Tissue Morphology","abnormal morphology of glandular epithelium","1.00E-02"," "," "," ","KCNE2,SHH","2"]
["Organ Development, Renal and Urological System Development and Function","function of kidney","1.00E-02"," "," "," ","AQP1,SOSTDC1","2"]
["Cellular Development, Cellular Growth and Proliferation, Embryonic Development, Nervous System Development and Function, Organ Development, Organismal Development, Tissue Development","proliferation of neural precursor cells","1.00E-02"," "," "," ","ID1,SHH","2"]
["Organismal Development","abnormal morphology of head","1.03E-02"," "," "," ","ARSG,E2F5,FOLR1,ID1,KLF2,PRLR,SHH,SOSTDC1","8"]
["Connective Tissue Disorders, Skeletal and Muscular Disorders","osteoporosis","1.03E-02"," "," "," ","ID1,KL","2"]
["Cardiovascular Disease, Organismal Injury and Abnormalities, Tissue Morphology","size of infarct","1.05E-02"," "," "," ","CAMK2A,SRR,UCP2","3"]
["Tissue Morphology","abnormal morphology of olfactory pit","1.06E-02"," "," "," ","SHH","1"]
["Gastrointestinal Disease","achlorhydria","1.06E-02"," "," "," ","KCNE2","1"]
["Psychological Disorders","anhedonia","1.06E-02"," "," "," ","GABBR1","1"]
["Cell-mediated Immune Response, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Hematological System Development and Function, Hematopoiesis, Lymphoid Tissue Structure and Development, Tissue Development","arrest in differentiation of thymocytes","1.06E-02"," "," "," ","SHH","1"]
["Gastrointestinal Disease, Organismal Injury and Abnormalities","atresia of anal canal","1.06E-02"," "," "," ","SHH","1"]
["Gene Expression","binding of GATA-4 binding site","1.06E-02"," "," "," ","ID1","1"]
["Gene Expression","binding of Nkx2.5 binding site","1.06E-02"," "," "," ","ID1","1"]
["Cell-To-Cell Signaling and Interaction, Reproductive System Development and Function","binding of ova","1.06E-02"," "," "," ","ACE","1"]
["Cell Death and Survival, Neurological Disease","cell death of CA1 neuron","1.06E-02"," "," "," ","UCP2","1"]
["Cell Morphology, Cellular Development, Connective Tissue Development and Function","conversion of fibroblast cell lines","1.06E-02"," "," "," ","PRLR","1"]
["Connective Tissue Disorders, Developmental Disorder, Embryonic Development, Organismal Development, Skeletal and Muscular Disorders, Tissue Development, Tissue Morphology","degeneration of notochord","1.06E-02"," "," "," ","SHH","1"]
["Digestive System Development and Function, Embryonic Development, Organ Development, Organismal Development, Tissue Development","development of anus","1.06E-02"," "," "," ","SHH","1"]
["Connective Tissue Development and Function, Embryonic Development, Organ Development, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development","development of basisphenoid bone","1.06E-02"," "," "," ","SHH","1"]
["Auditory and Vestibular System Development and Function, Connective Tissue Development and Function, Embryonic Development, Organ Development, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development","development of malleus","1.06E-02"," "," "," ","SHH","1"]
["Embryonic Development, Organismal Development, Tissue Development","development of nasal capsule","1.06E-02"," "," "," ","SHH","1"]
["Cardiovascular System Development and Function","development of vascular plexus","1.06E-02"," "," "," ","SHH","1"]
["Auditory Disease, Organismal Injury and Abnormalities","edema of ear","1.06E-02"," "," "," ","KLF2","1"]
["Cellular Movement, Hematological System Development and Function","extravasation of lymphocytes","1.06E-02"," "," "," ","ENPP2","1"]
["Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism","formation of 9-cis-retinol","1.06E-02"," "," "," ","RDH5","1"]
["Organismal Development","formation of digit","1.06E-02"," "," "," ","SHH","1"]
["Nervous System Development and Function, Organ Development","growth of diencephalon","1.06E-02"," "," "," ","SHH","1"]
["Cellular Function and Maintenance","homeostasis of water","1.06E-02"," "," "," ","AQP1","1"]
["Cancer, Dermatological Diseases and Conditions, Organismal Injury and Abnormalities","hyperplasia of hair follicle","1.06E-02"," "," "," ","KL","1"]
["Behavior","hypolocomotion","1.06E-02"," "," "," ","GABBR1","1"]
["Developmental Disorder, Organismal Injury and Abnormalities, Renal and Urological Disease","hypoplasia of renal cortex","1.06E-02"," "," "," ","KL","1"]
["Developmental Disorder, Organismal Injury and Abnormalities, Renal and Urological Disease","hypoplasia of renal medulla","1.06E-02"," "," "," ","ACE","1"]
["Auditory and Vestibular System Development and Function, Organ Morphology, Organismal Development","lack of cochlear duct","1.06E-02"," "," "," ","SHH","1"]
["Organismal Development, Skeletal and Muscular System Development and Function","lack of hindlimb","1.06E-02"," "," "," ","SHH","1"]
["Auditory and Vestibular System Development and Function, Connective Tissue Development and Function, Organ Morphology, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development","lack of horizontal semicircular canal","1.06E-02"," "," "," ","SHH","1"]
["Auditory and Vestibular System Development and Function, Organ Morphology, Organismal Development","lack of saccule","1.06E-02"," "," "," ","SHH","1"]
["Nervous System Development and Function","lack of vestibulocochlear cranial nerve ganglion","1.06E-02"," "," "," ","SHH","1"]
["Molecular Transport","leakage of H+","1.06E-02"," "," "," ","UCP2","1"]
["Embryonic Development, Organ Development, Organ Morphology, Organismal Development, Respiratory System Development and Function, Tissue Development","morphogenesis of trachea","1.06E-02"," "," "," ","SHH","1"]
["Cardiovascular System Development and Function, Tissue Morphology","morphology of umbilical artery","1.06E-02"," "," "," ","KLF2","1"]
["Cardiovascular Disease, Cardiovascular System Development and Function, Organismal Injury and Abnormalities, Tissue Morphology","permeability of vascular endothelial tissue","1.06E-02"," "," "," ","KL","1"]
["Cancer, Cellular Development, Cellular Growth and Proliferation, Organismal Injury and Abnormalities, Tumor Morphology","proliferation of medulloblastoma cells","1.06E-02"," "," "," ","SHH","1"]
["Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Organ Development, Tissue Development","proliferation of spinal neuron","1.06E-02"," "," "," ","SHH","1"]
["Organismal Development","quantity of digit","1.06E-02"," "," "," ","SHH","1"]
["Cell Cycle, Visual System Development and Function","re-entry into cell cycle progression of lens fiber cells","1.06E-02"," "," "," ","E2F5","1"]
["Cardiovascular System Development and Function, Organ Morphology","size of atrium","1.06E-02"," "," "," ","ACE","1"]
["Cell Death and Survival, Embryonic Development","survival of neural crest cells","1.06E-02"," "," "," ","SHH","1"]
["Carbohydrate Metabolism","quantity of carbohydrate","1.06E-02"," ","0.625"," ","AQP1,ENPP2,KLF2,PRLR,UCP2","5"]
["Cellular Development, Cellular Growth and Proliferation, Hematological System Development and Function, Hematopoiesis","expansion of hematopoietic progenitor cells","1.07E-02"," "," "," ","KLF2,SHH","2"]
["Cell-To-Cell Signaling and Interaction, Nervous System Development and Function","long term depression of synapse","1.07E-02"," "," "," ","ARHGEF9,CAMK2A","2"]
["Embryonic Development, Organ Development, Organ Morphology, Organismal Development, Tissue Development, Visual System Development and Function","morphogenesis of camera-type eye","1.07E-02"," "," "," ","AQP1,SHH","2"]
["Tissue Morphology","quantity of stem cells","1.10E-02"," "," "," ","KL,SHH","2"]
["Skeletal and Muscular System Development and Function","size of bone","1.11E-02"," "," "," ","ID1,KL,PRLR,SHH","4"]
["Cellular Development, Cellular Growth and Proliferation, Embryonic Development, Organismal Development, Tissue Development","development of embryonic cells","1.14E-02"," "," "," ","PRLR,SHH","2"]
["Cardiovascular System Development and Function","development of vasculature","1.15E-02"," "," "," ","ACE,ENPP2,ID1,KLF2,SHH","5"]
["Cell-To-Cell Signaling and Interaction, Nervous System Development and Function","neurotransmission","1.16E-02"," "," "," ","ARHGEF9,CAMK2A,GABBR1,NRXN1","4"]
["Cardiovascular System Development and Function","abnormal morphology of vasculature","1.17E-02"," "," "," ","ACE,ID1,SHH","3"]
["Gene Expression","transactivation of RNA","1.17E-02"," "," "," ","ID1,IGF2BP1,UCP2","3"]
["Skeletal and Muscular System Development and Function","abnormal morphology of smooth muscle","1.18E-02"," "," "," ","KLF2,SHH","2"]
["Cell-To-Cell Signaling and Interaction, Nervous System Development and Function","excitatory postsynaptic potential of neurons","1.18E-02"," "," "," ","ARHGEF9,CAMK2A","2"]
["Organismal Injury and Abnormalities, Renal and Urological Disease","polyuria","1.18E-02"," "," "," ","ACE,AQP1","2"]
["Tissue Morphology","abnormal morphology of epithelial tissue","1.23E-02"," "," "," ","ARSG,KCNE2,KLF2,PRLR,SHH","5"]
["Organ Morphology, Organismal Development, Renal and Urological System Development and Function","abnormal morphology of small kidney","1.25E-02"," "," "," ","ACE,KL","2"]
["Tissue Morphology","abnormal morphology of dilated allantois","1.32E-02"," "," "," ","ENPP2","1"]
["Organ Morphology, Reproductive System Development and Function","abnormal morphology of dilated rete testis","1.32E-02"," "," "," ","AQP1","1"]
["Cell Signaling, Molecular Transport, Vitamin and Mineral Metabolism","abnormal quantity of Ca2+","1.32E-02"," "," "," ","PRLR","1"]
["Amino Acid Metabolism, Molecular Transport, Small Molecule Biochemistry","abnormal quantity of homocysteine","1.32E-02"," "," "," ","FOLR1","1"]
["Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response, Tissue Development","accumulation of gamma-delta T lymphocytes","1.32E-02"," "," "," ","KLF2","1"]
["Behavior","avoidance","1.32E-02"," "," "," ","TRPM3","1"]
["Neurological Disease","communicating hydrocephalus","1.32E-02"," "," "," ","E2F5","1"]
["Endocrine System Disorders, Gastrointestinal Disease, Organismal Injury and Abnormalities","damage of islets of Langerhans","1.32E-02"," "," "," ","UCP2","1"]
["Embryonic Development, Organismal Development, Tissue Development","development of mandibular cartilage","1.32E-02"," "," "," ","SHH","1"]
["Cellular Development, Embryonic Development, Organ Development, Organismal Development, Reproductive System Development and Function, Tissue Development","differentiation of mammary epithelium","1.32E-02"," "," "," ","PRLR","1"]
["Cellular Development","differentiation of multinucleated cells","1.32E-02"," "," "," ","GABBR1","1"]
["Molecular Transport, Protein Trafficking","excretion of protein","1.32E-02"," "," "," ","KL","1"]
["Neurological Disease, Ophthalmic Disease, Organismal Injury and Abnormalities","gliosis of retina","1.32E-02"," "," "," ","PRLR","1"]
["Connective Tissue Development and Function, Embryonic Development, Organ Development, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development","growth of metatarsal bone","1.32E-02"," "," "," ","KL","1"]
["Gastrointestinal Disease","hypochlorhydria","1.32E-02"," "," "," ","KCNE2","1"]
["Connective Tissue Disorders, Developmental Disorder, Skeletal and Muscular Disorders","hypoplasia of ala temporali","1.32E-02"," "," "," ","SHH","1"]
["Connective Tissue Disorders, Developmental Disorder, Gastrointestinal Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders","hypoplasia of premaxilla","1.32E-02"," "," "," ","SHH","1"]
["Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities","initiation of leukemia","1.32E-02"," "," "," ","ID1","1"]
["Digestive System Development and Function, Organ Morphology, Organismal Development","lack of tongue","1.32E-02"," "," "," ","SHH","1"]
["Cardiovascular System Development and Function","maturation of vasculature","1.32E-02"," "," "," ","KLF2","1"]
["Lipid Metabolism, Small Molecule Biochemistry","metabolism of palmitic acid","1.32E-02"," "," "," ","DBP","1"]
["Cell Death and Survival, Cellular Compromise, Neurological Disease, Tissue Morphology","neurodegeneration of cholinergic neurons","1.32E-02"," "," "," ","SHH","1"]
["Cellular Development, Cellular Growth and Proliferation, Embryonic Development, Nervous System Development and Function, Organ Development, Organismal Development, Tissue Development","proliferation of cerebellar granule neuron precursor cells","1.32E-02"," "," "," ","SHH","1"]
["Cellular Development, Cellular Growth and Proliferation, Hematological System Development and Function, Humoral Immune Response, Lymphoid Tissue Structure and Development","proliferation of germinal center B lymphocytes","1.32E-02"," "," "," ","SHH","1"]
["Cellular Assembly and Organization","replenishment","1.32E-02"," "," "," ","IDE","1"]
["Nervous System Development and Function, Organismal Development","secretion of cerebrospinal fluid","1.32E-02"," "," "," ","E2F5","1"]
["Neurological Disease, Skeletal and Muscular Disorders","tremor of limb","1.32E-02"," "," "," ","PLP1","1"]
["Embryonic Development, Tissue Morphology","abnormal morphology of visceral yolk sac","1.33E-02"," "," "," ","F5,SHH","2"]
["Vitamin and Mineral Metabolism","quantity of vitamin","1.33E-02"," "," "," ","FOLR1,KL","2"]
["Carbohydrate Metabolism, Molecular Transport, Small Molecule Biochemistry","concentration of D-glucose","1.36E-02"," ","0.000"," ","AQP1,ENPP2,PRLR,UCP2","4"]
["Tissue Development","branching of epithelial tissue","1.36E-02"," "," "," ","PRLR,SHH","2"]
["Organismal Injury and Abnormalities","intracranial hemorrhage","1.36E-02"," "," "," ","E2F5,ID1","2"]
["Molecular Transport","quantity of anion","1.36E-02"," "," "," ","KCNE2,KL","2"]
["Cellular Development, Skeletal and Muscular System Development and Function, Tissue Development","differentiation of osteoblasts","1.37E-02"," "," "," ","GABBR1,ID1,SHH","3"]
["Organismal Injury and Abnormalities","dehydration of mice","1.44E-02"," "," "," ","AQP1,E2F5","2"]
["Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development","development of neuroglia","1.48E-02"," "," "," ","PLP1,SHH","2"]
["Cell Morphology","morphology of cells","1.51E-02"," "," "," ","ARHGEF9,ARSG,CAMK2A,ENPP2,GABBR1,ID1,KCNE2,KL,KLF2,PLP1,PRLR,SHH","12"]
["Cellular Development","maturation of cells","1.52E-02"," "," "," ","CAMK2A,KLF2,PLP1,SHH","4"]
["Cardiovascular System Development and Function, Embryonic Development, Organ Development, Organ Morphology, Organismal Development, Tissue Development","looping morphogenesis of heart","1.52E-02"," "," "," ","FOLR1,SHH","2"]
["Developmental Disorder, Ophthalmic Disease, Organismal Injury and Abnormalities","microphthalmia","1.52E-02"," "," "," ","ID1,SHH","2"]
["Nervous System Development and Function","thermal nociception","1.52E-02"," "," "," ","GABBR1,TRPM3","2"]
["Organismal Survival","neonatal death","1.53E-02","Decreased","-2.236","bias","F5,ID1,NRXN1,SHH,SOSTDC1","5"]
["Neurological Disease","ataxia","1.53E-02"," "," "," ","E2F5,GABBR1,PLP1","3"]
["Digestive System Development and Function, Organ Morphology, Organismal Development","abnormal morphology of stomach","1.56E-02"," "," "," ","KCNE2,SHH","2"]
["Cellular Development, Hematological System Development and Function, Hematopoiesis","arrest in differentiation of lymphocytes","1.56E-02"," "," "," ","ID1,SHH","2"]
["Behavior","spatial learning","1.57E-02"," "," "," ","ARHGEF9,ARSG,CAMK2A","3"]
["Organ Morphology, Reproductive System Development and Function","abnormal morphology of chorionic plate","1.58E-02"," "," "," ","ENPP2","1"]
["Connective Tissue Disorders, Developmental Disorder, Organismal Development, Skeletal and Muscular Disorders, Tissue Morphology","abnormal morphology of maxillary prominence","1.58E-02"," "," "," ","SHH","1"]
["Organ Morphology, Organismal Development, Renal and Urological System Development and Function","abnormal morphology of renal papilla","1.58E-02"," "," "," ","ACE","1"]
["Digestive System Development and Function, Organ Morphology, Organismal Development","abnormal morphology of submandibular gland","1.58E-02"," "," "," ","SHH","1"]
["Auditory and Vestibular System Development and Function, Connective Tissue Development and Function, Organ Morphology, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development","abnormal morphology of superior semicircular canal","1.58E-02"," "," "," ","SHH","1"]
["Developmental Disorder, Skeletal and Muscular Disorders","adactyly","1.58E-02"," "," "," ","SHH","1"]
["Nervous System Development and Function","ensheathment of axons","1.58E-02"," "," "," ","PLP1","1"]
["Neurological Disease","formation of axon spheroid","1.58E-02"," "," "," ","PLP1","1"]
["Embryonic Development, Organismal Development, Tissue Development","formation of limb bud","1.58E-02"," "," "," ","SHH","1"]
["Neurological Disease","hypomyelination of axons","1.58E-02"," "," "," ","PLP1","1"]
["Auditory and Vestibular System Development and Function, Organ Morphology, Organismal Development","lack of endolymphatic duct","1.58E-02"," "," "," ","SHH","1"]
["Lipid Metabolism, Small Molecule Biochemistry","metabolism of linoleic acid","1.58E-02"," "," "," ","DBP","1"]
["Digestive System Development and Function, Organ Morphology, Organismal Development","morphology of crypt","1.58E-02"," "," "," ","IGF2BP1","1"]
["Endocrine System Disorders, Gastrointestinal Disease, Immunological Disease, Metabolic Disease","onset of insulin-dependent diabetes mellitus","1.58E-02"," "," "," ","UCP2","1"]
["Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry","quantity of galactosylceramide","1.58E-02"," "," "," ","PLP1","1"]
["Organ Morphology","size of spinal cord","1.58E-02"," "," "," ","SHH","1"]
["Nervous System Development and Function","thermoception","1.58E-02"," "," "," ","TRPM3","1"]
["Organismal Injury and Abnormalities","tracheoesophageal fistula","1.58E-02"," "," "," ","SHH","1"]
["Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function","proliferation of neuroglia","1.60E-02"," "," "," ","PLP1,SHH","2"]
["Embryonic Development, Organ Development, Organ Morphology, Organismal Development, Respiratory System Development and Function, Tissue Development","abnormal morphology of lung","1.72E-02"," "," "," ","ID1,KLF2,SHH","3"]
["Cell-mediated Immune Response, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Hematological System Development and Function, Hematopoiesis, Lymphoid Tissue Structure and Development, Tissue Development","T cell development","1.81E-02"," ","1.981","bias","F5,ID1,KLF2,PLP1,SHH","5"]
["Tissue Morphology","abnormal morphology of frontonasal process","1.84E-02"," "," "," ","SHH","1"]
["Organ Morphology, Organismal Development","abnormal morphology of lacrimal gland","1.84E-02"," "," "," ","PRLR","1"]
["Embryonic Development, Tissue Morphology","abnormal morphology of optic stalk","1.84E-02"," "," "," ","SHH","1"]
["Auditory and Vestibular System Development and Function, Cardiovascular System Development and Function, Embryonic Development, Organ Development, Organismal Development, Tissue Development","angiogenesis of ear","1.84E-02"," "," "," ","KLF2","1"]
["Cell Death and Survival","cell viability of melanoma cell lines","1.84E-02"," "," "," ","SHH","1"]
["Embryonic Development, Organismal Development, Tissue Development","development of floor plate","1.84E-02"," "," "," ","SHH","1"]
["Cell-mediated Immune Response, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Hematological System Development and Function, Hematopoiesis, Lymphoid Tissue Structure and Development, Tissue Development","differentiation of TREG cells","1.84E-02"," "," "," ","ID1","1"]
["Cellular Development, Embryonic Development, Nervous System Development and Function, Organismal Development, Tissue Development","differentiation of granule neuron progenitor cells","1.84E-02"," "," "," ","SHH","1"]
["Immunological Disease, Inflammatory Disease, Inflammatory Response, Neurological Disease","experimental allergic encephalomyelitis (chronic relapsing)","1.84E-02"," "," "," ","PLP1","1"]
["Cellular Development, Cellular Growth and Proliferation, Embryonic Development, Nervous System Development and Function, Organ Development, Organismal Development, Tissue Development","formation of neural precursor cells","1.84E-02"," "," "," ","SHH","1"]
["Inflammatory Response, Skeletal and Muscular Disorders","inflammation of footpad","1.84E-02"," "," "," ","KLF2","1"]
["Inflammatory Disease, Neurological Disease","inflammatory demyelinating disease","1.84E-02"," "," "," ","PLP1","1"]
["Endocrine System Development and Function, Small Molecule Biochemistry","metabolism of androgen","1.84E-02"," "," "," ","SHH","1"]
["Cellular Movement, Connective Tissue Development and Function","mobility of fibroblast cell lines","1.84E-02"," "," "," ","ENPP2","1"]
["Embryonic Development, Organismal Development, Tissue Development","morphogenesis of hindgut","1.84E-02"," "," "," ","SHH","1"]
["Cell Morphology, Organ Morphology, Skeletal and Muscular System Development and Function, Tissue Morphology","morphology of smooth muscle cells","1.84E-02"," "," "," ","KLF2","1"]
["Inflammatory Disease, Neurological Disease","neuritic dystrophy","1.84E-02"," "," "," ","IDE","1"]
["Organ Morphology, Reproductive System Development and Function","quantity of primary ovarian follicle","1.84E-02"," "," "," ","PRLR","1"]
["Digestive System Development and Function, Organ Morphology","size of intestinal villus","1.84E-02"," "," "," ","IGF2BP1","1"]
["Drug Metabolism, Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism","synthesis of alitretinoin","1.84E-02"," "," "," ","RDH5","1"]
["Cell-mediated Immune Response, Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking","transendothelial migration of T lymphocytes","1.84E-02"," "," "," ","ENPP2","1"]
["Behavior","anxiety","1.86E-02"," "," "," ","ARHGEF9,CAMK2A,GABBR1","3"]
["Cancer, Dermatological Diseases and Conditions, Organismal Injury and Abnormalities","hyperplasia of epidermis","1.91E-02"," "," "," ","KL,SHH","2"]
["Digestive System Development and Function, Organismal Development","morphology of tooth","1.95E-02"," "," "," ","SHH,SOSTDC1","2"]
["Cell-To-Cell Signaling and Interaction, Molecular Transport, Small Molecule Biochemistry","secretion of neurotransmitter","2.00E-02"," "," "," ","CAMK2A,NRXN1","2"]
["Cancer, Organismal Injury and Abnormalities","incidence of malignant tumor","2.00E-02"," "," "," ","ID1,PRLR,SHH","3"]
["Organismal Injury and Abnormalities","Bleeding","2.04E-02"," ","-1.977","bias","E2F5,F5,ID1,KLF2","4"]
["Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development","development of central nervous system cells","2.04E-02"," "," "," ","PLP1,SHH","2"]
["Behavior, Nervous System Development and Function","startle response","2.04E-02"," "," "," ","SHH,SRR","2"]
["Nervous System Development and Function","abnormal morphology of ependyma","2.10E-02"," "," "," ","E2F5","1"]
["Tissue Morphology","abnormal morphology of optic cup","2.10E-02"," "," "," ","SHH","1"]
["Cell Death and Survival","apoptosis of myeloma cell lines","2.10E-02"," "," "," ","SHH","1"]
["Cardiovascular Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders","atrial fibrillation","2.10E-02"," "," "," ","ACE","1"]
["Neurological Disease","clonic seizure","2.10E-02"," "," "," ","GABBR1","1"]
["Organismal Development, Visual System Development and Function","dark adaptation of mice","2.10E-02"," "," "," ","RDH5","1"]
["Cardiovascular System Development and Function, Embryonic Development, Organismal Development","development of aortic arch","2.10E-02"," "," "," ","SHH","1"]
["Digestive System Development and Function, Embryonic Development, Organ Development, Organismal Development, Tissue Development","development of stomach","2.10E-02"," "," "," ","SHH","1"]
["Cell-mediated Immune Response, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Hematological System Development and Function, Hematopoiesis, Lymphoid Tissue Structure and Development, Tissue Development","differentiation of immature T lymphocytes","2.10E-02"," "," "," ","SHH","1"]
["Cell-mediated Immune Response, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Hematological System Development and Function, Hematopoiesis, Lymphoid Tissue Structure and Development, Tissue Development","differentiation of pro-T3 thymocytes","2.10E-02"," "," "," ","ID1","1"]
["Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities","hyperplasia of gastric epithelium","2.10E-02"," "," "," ","SHH","1"]
["Developmental Disorder, Ophthalmic Disease, Organismal Injury and Abnormalities","hypoplasia of retina","2.10E-02"," "," "," ","ID1","1"]
["Cardiovascular System Development and Function, Organismal Development","morphogenesis of capillary vessel","2.10E-02"," "," "," ","SHH","1"]
["Embryonic Development, Organ Development, Organ Morphology, Organismal Development, Respiratory System Development and Function, Tissue Development","morphogenesis of lung lobe","2.10E-02"," "," "," ","SHH","1"]
["Cell Death and Survival, Cellular Compromise, Neurological Disease, Tissue Morphology","neurodegeneration of dopaminergic neurons","2.10E-02"," "," "," ","SHH","1"]
["Immunological Disease, Inflammatory Disease, Inflammatory Response, Neurological Disease","onset of experimental autoimmune encephalomyelitis","2.10E-02"," "," "," ","PLP1","1"]
["Cell-To-Cell Signaling and Interaction, Nervous System Development and Function","paired-pulse inhibition","2.10E-02"," "," "," ","NRXN1","1"]
["Neurological Disease","paraparesis","2.10E-02"," "," "," ","PLP1","1"]
["Digestive System Development and Function","quantity of tooth","2.10E-02"," "," "," ","SHH","1"]
["Cell Cycle, Connective Tissue Development and Function","re-entry into cell cycle progression of fibroblast cell lines","2.10E-02"," "," "," ","ID1","1"]
["Embryonic Development, Nervous System Development and Function, Organ Development, Organismal Development, Tissue Development","regionalization of telencephalon","2.10E-02"," "," "," ","SHH","1"]
["Organismal Survival","sudden death","2.10E-02"," "," "," ","ACE","1"]
["Cell Morphology, Cellular Compromise, Neurological Disease, Organismal Injury and Abnormalities","swelling of axons","2.10E-02"," "," "," ","PLP1","1"]
["Cellular Development, Embryonic Development","differentiation of embryonic cell lines","2.14E-02"," "," "," ","Rhox4b (includes others),SHH","2"]
["Free Radical Scavenging","generation of reactive oxygen species","2.18E-02"," "," "," ","KL,UCP2","2"]
["Cell Morphology, Cell-To-Cell Signaling and Interaction, Nervous System Development and Function","plasticity of synapse","2.18E-02"," "," "," ","ARHGEF9,CAMK2A","2"]
["Cell Cycle","G1/S phase transition","2.23E-02"," "," "," ","CAMK2A,E2F5","2"]
["Neurological Disease","Movement Disorders","2.26E-02"," ","-0.083","bias","DBP,E2F5,GABBR1,PLP1,SHH","5"]
["Developmental Disorder, Neurological Disease, Organismal Injury and Abnormalities","congenital malformation of brain","2.27E-02"," "," "," ","E2F5,KLF2,SHH","3"]
["Nervous System Development and Function","abnormal morphology of central nervous system","2.35E-02"," "," "," ","ARSG,E2F5,ID1,PLP1,SHH","5"]
["Digestive System Development and Function, Organismal Development, Tissue Morphology","abnormal morphology of enamel","2.36E-02"," "," "," ","SOSTDC1","1"]
["Digestive System Development and Function, Organ Morphology, Organismal Development, Respiratory System Development and Function","abnormal morphology of pharynx","2.36E-02"," "," "," ","SHH","1"]
["Neurological Disease, Ophthalmic Disease, Organismal Injury and Abnormalities, Tissue Morphology","degeneration of retinal pigment epithelium","2.36E-02"," "," "," ","KL","1"]
["Digestive System Development and Function, Embryonic Development, Organ Development, Organismal Development","development of incisor","2.36E-02"," "," "," ","SHH","1"]
["Embryonic Development, Organ Development, Organ Morphology, Organismal Development, Organismal Injury and Abnormalities, Renal and Urological Disease, Renal and Urological System Development and Function, Tissue Development","expansion of mesangial matrix","2.36E-02"," "," "," ","KL","1"]
["Digestive System Development and Function, Embryonic Development, Organ Development, Organismal Development, Tissue Development","formation of esophagus","2.36E-02"," "," "," ","SHH","1"]
["Developmental Disorder, Gastrointestinal Disease","hypertrophy of stomach","2.36E-02"," "," "," ","KCNE2","1"]
["Embryonic Development, Tissue Morphology","lack of ophthalmic vesicle","2.36E-02"," "," "," ","FOLR1","1"]
["Nervous System Development and Function, Visual System Development and Function","photoresponse of retina","2.36E-02"," "," "," ","PRLR","1"]
["Cardiovascular System Development and Function, Connective Tissue Development and Function, Organismal Development, Tissue Morphology","quantity of pericytes","2.36E-02"," "," "," ","KLF2","1"]
["Cell Morphology, Nervous System Development and Function, Tissue Morphology","abnormal morphology of axons","2.38E-02"," "," "," ","GABBR1,PLP1","2"]
["Cardiovascular System Development and Function","morphogenesis of cardiovascular system","2.38E-02"," "," "," ","FOLR1,ID1,SHH","3"]
["Embryonic Development, Organismal Development, Tissue Development","development of somites","2.43E-02"," "," "," ","ENPP2,F5","2"]
["Behavior","exploratory behavior","2.43E-02"," "," "," ","ARHGEF9,ARSG","2"]
["Digestive System Development and Function, Embryonic Development, Organ Development, Organismal Development","tooth development","2.43E-02"," "," "," ","SHH,SOSTDC1","2"]
["Digestive System Development and Function","development of digestive system","2.43E-02"," "," "," ","IGF2BP1,SHH,SOSTDC1,UPF2","4"]
["Cell-To-Cell Signaling and Interaction, Nervous System Development and Function","synaptic transmission","2.46E-02"," "," "," ","CAMK2A,GABBR1,NRXN1","3"]
["Embryonic Development, Organismal Development, Tissue Development","mesoderm development","2.48E-02"," "," "," ","SHH,SLC31A1","2"]
["Hematological Disease, Immunological Disease","lymphopenia","2.53E-02"," "," "," ","ID1,KLF2","2"]
["Cell Morphology","size of cells","2.55E-02"," "," "," ","ENPP2,ID1,KL,KLF2","4"]
["Cellular Growth and Proliferation","proliferation of cells","2.56E-02"," ","0.430"," ","CAMK2A,ENPP2,Erdr1,GABBR1,ID1,IGF2BP1,KL,KLF2,MID1,PLP1,PRLR,SHH,UCP2","13"]
["Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry","accumulation of lipid","2.57E-02"," "," "," ","ENPP2,KL,RDH5","3"]
["Behavior, Nervous System Development and Function","memory","2.57E-02"," "," "," ","CAMK2A,GABBR1,SRR","3"]
["Connective Tissue Development and Function, Hematological System Development and Function, Hematopoiesis, Organismal Development, Tissue Morphology","quantity of red blood cells","2.60E-02"," "," "," ","AQP1,ID1,KLF2","3"]
["Nervous System Development and Function","abnormal morphology of lumbar dorsal root ganglion","2.62E-02"," "," "," ","GABBR1","1"]
["Digestive System Development and Function, Organismal Development, Tissue Morphology","abnormal morphology of molar crown","2.62E-02"," "," "," ","SOSTDC1","1"]
["Auditory and Vestibular System Development and Function, Connective Tissue Development and Function, Organ Morphology, Organismal Development, Skeletal and Muscular System Development and Function, Tissue Development","abnormal morphology of posterior semicircular canal","2.62E-02"," "," "," ","SHH","1"]
["Organ Morphology, Organismal Development, Renal and Urological System Development and Function","abnormal morphology of renal pelvis","2.62E-02"," "," "," ","ACE","1"]
["Neurological Disease","absence seizure","2.62E-02"," "," "," ","GABBR1","1"]
["Cell Signaling, Molecular Transport, Vitamin and Mineral Metabolism","accumulation of Ca2+","2.62E-02"," "," "," ","GABBR1","1"]
["Organ Morphology, Organismal Injury and Abnormalities, Renal and Urological Disease","atrophy of renal medulla","2.62E-02"," "," "," ","ACE","1"]
["Embryonic Development, Organismal Development, Tissue Development","development of allantois","2.62E-02"," "," "," ","ENPP2","1"]
["Cellular Function and Maintenance, Molecular Transport, Small Molecule Biochemistry","homeostasis of Cu2+","2.62E-02"," "," "," ","SLC31A1","1"]
["Metabolic Disease","hyperleptinemia","2.62E-02"," "," "," ","PRLR","1"]
["Cellular Compromise, Organismal Injury and Abnormalities, Renal and Urological Disease","injury of podocytes","2.62E-02"," "," "," ","CAMK2A","1"]
["Connective Tissue Development and Function, Tissue Morphology","mass of subcutaneous fat","2.62E-02"," "," "," ","ENPP2","1"]
["Lipid Metabolism, Small Molecule Biochemistry","metabolism of arachidonic acid","2.62E-02"," "," "," ","DBP","1"]
["Embryonic Development, Tissue Morphology","morphology of Reichert's membrane","2.62E-02"," "," "," ","SLC31A1","1"]
["Cell Morphology, Cell-To-Cell Signaling and Interaction, Nervous System Development and Function","plasticity of neuronal synapse","2.62E-02"," "," "," ","CAMK2A","1"]
["Behavior, Reproductive System Development and Function","pup retrieval","2.62E-02"," "," "," ","PRLR","1"]
["Cellular Development, Cellular Growth and Proliferation, Connective Tissue Development and Function","proliferation of fibroblast cell lines","2.64E-02"," "," "," ","ID1,KLF2,PRLR,SHH","4"]
["Cardiovascular Disease, Organismal Injury and Abnormalities","formation of vascular lesion","2.78E-02"," "," "," ","F5,KLF2","2"]
["Cellular Assembly and Organization, Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development","growth of neurites","2.82E-02"," "," "," ","CAMK2A,ENPP2,MID1","3"]
["Embryonic Development","size of embryo","2.83E-02"," ","1.982","bias","F5,KLF2,SHH,SLC31A1","4"]
["Connective Tissue Disorders, Developmental Disorder, Skeletal and Muscular Disorders","kyphosis","2.84E-02"," "," "," ","KL,PLP1","2"]
["Behavior, Nervous System Development and Function","spatial memory","2.84E-02"," "," "," ","CAMK2A,SRR","2"]
["Connective Tissue Development and Function, Tissue Morphology","quantity of connective tissue cells","2.85E-02"," "," "," ","ID1,KL,KLF2","3"]
["Metabolic Disease","glucose metabolism disorder","2.86E-02"," ","-1.521","bias","ACE,ID1,IDE,PRLR,STEAP2,UCP2","6"]
["Organ Morphology, Organismal Development, Organismal Injury and Abnormalities, Renal and Urological Disease, Renal and Urological System Development and Function","atrophy of renal cortex","2.88E-02"," "," "," ","ACE","1"]
["Skeletal and Muscular System Development and Function","closure of suture","2.88E-02"," "," "," ","ID1","1"]
["Embryonic Development, Nervous System Development and Function, Organismal Development, Tissue Development","development of otic vesicle","2.88E-02"," "," "," ","SHH","1"]
["Hair and Skin Development and Function","formation of melanin","2.88E-02"," "," "," ","SHH","1"]
["Embryonic Development, Organismal Development, Tissue Development","formation of prostatic bud","2.88E-02"," "," "," ","SHH","1"]
["Organ Development, Reproductive System Development and Function","growth of prostate gland","2.88E-02"," "," "," ","PRLR","1"]
["Cellular Function and Maintenance","hyperpolarization of membrane","2.88E-02"," "," "," ","KCNE2","1"]
["Connective Tissue Development and Function, Tissue Morphology","mass of abdominal fat pad","2.88E-02"," "," "," ","PRLR","1"]
["Embryonic Development, Organismal Development, Tissue Development","morphogenesis of embryonic foregut","2.88E-02"," "," "," ","SHH","1"]
["Cardiovascular System Development and Function, Cell Morphology, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Organismal Development, Tissue Development","morphogenesis of endothelial cells","2.88E-02"," "," "," ","ID1","1"]
["Cell-To-Cell Signaling and Interaction, Cellular Function and Maintenance, Hematological System Development and Function, Hematopoiesis, Inflammatory Response","phagocytosis of thymocytes","2.88E-02"," "," "," ","UCP2","1"]
["Cellular Assembly and Organization, Cellular Function and Maintenance","quantity of microtubules","2.88E-02"," "," "," ","IDE","1"]