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["Table S1. Statistical analysis related to Figures and Supplemental Figures"]
["Fig. 1C","Left: Student’s t-test, Saline: n = 5, PCP: n = 5, t(8) = 3.534, p < 0.01."]
[null,"Middle: Two-way ANOVA followed by Bonferroni post hoc test, Model: F(1, 24) = 21.255, p < 0.001, Spine type: F(2, 24) = 50.279, p < 0.001, Model x Spine type interaction: F(2, 24) = 2.527, p = 0.101, Thin vs. Mushroom: p < 0.001, Thin vs. Stubby: p < 0.001."]
[null,"Right: Kolmogorov-Smirnov D = 0.034, p = 0.138."]
["Fig. 1D","Left: Student’s t-test, Saline: n = 5, PCP: n = 5, t(8) = 1.993, p = 0.081."]
[null,"Middle: Two-way ANOVA followed by Bonferroni post hoc test, Model: F(1, 24) = 4.213, p = 0.051, Spine type: F(2, 24) = 127.412, p < 0.001, Model x Spine type interaction: F(2, 24) = 0.590, p = 0.562, Thin vs. Mushroom: p < 0.001, Thin vs. Stubby: p < 0.001."]
[null,"Right: Kolmogorov-Smirnov D = 0.017, p = 0.663."]
["Fig. 1E","Left: Student’s t-test, Saline: n = 5, PCP: n = 5, t(8) = 0.206, p = 0.842."]
[null,"Middle: Two-way ANOVA followed by Bonferroni post hoc test, Model: F(1, 24) = 0.048, p = 0.828, Spine type: F(2, 24) = 188.915, p < 0.001, Model x Spine type interaction: F(2, 24) = 0.233, p = 0.794, Thin vs. Mushroom: p < 0.001, Thin vs. Stubby: p < 0.001."]
[null,"Right: Kolmogorov-Smirnov D = 0.022, p = 0.521."]
["Fig. 1G","Student’s t-test, Saline: n = 5, PCP: n = 5."]
[null,"VGLUT1: Intensity, t(8) = 1.605, p = 0.147, Density, t(8) = 2.461, p < 0.05, Size, t(8) = 1.557, p = 0.158. VGLUT2: Intensity, t(8) = 1.112, p = 0.299, Density, t(8) = 1.145, p = 0.285, Size, t(8) = 0.510, p = 0.624."]
[null,"Bottom: Student’s t-test. VGLUT1: Intensity, t(8) = 0.980, p = 0.356, Density, t(8) = 1.280, p = 0.236, Size, t(8) = 0.881, p = 0.404, VGLUT2: Intensity, t(8) = 0.322, p = 0.756, Density, t(8) = 0.169, p = 0.870, Size, t(8) = 1.242, p = 0.249."]
["Fig. 1I","Student’s t-test, Saline: n = 5, PCP: n = 5."]
[null,"GAD65 in layer 2–3: Intensity, t(8) = 0.612, p = 0.558, Density, t(8) = 0.720, p = 0.492, Size, t(8) = 0.540, p = 0.604. PV in layer 2–3: Intensity, t(8) = 1.770, p = 0.115, Per soma, t(8) = 2.472, p < 0.05, Size, t(8) = 0.349, p = 0.736."]
[null,"GAD65 in layer 5: Intensity, t(8) = 0.497, p = 0.633, Density, t(8) = 0.428, p = 0.680, Size, t(8) = 1.990, p = 0.082, PV in layer 5: Intensity, t(8) = 1.013, p = 0.341, Per soma, t(8) = 0.988, p = 0.352, Size, t(8) = 1.381, p = 0.205."]
["Fig. 2E","left: One-way repeated measures ANOVA followed by Bonferroni post hoc test, 20 cells obtained from 3 mice, Treatment: F(1.159, 22.012) = 49.924, p < 0.001, DCZ vs Pretreatment: p < 0.001, DCZ vs VEH: p < 0.001."]
[null,"right: One-way repeated measures ANOVA followed by Bonferroni post hoc test, 20 cells obtained from 3 mice, Treatment: F(1.026, 19.498) = 36.242, p < 0.001, DCZ vs Pretreatment: p < 0.001, DCZ vs VEH: p < 0.001."]
["Fig. 2J","Left: Two-way repeated measures ANOVA, n = 8, Delay x Drug interaction: F(2, 14) = 0.268, p = 0.769, Delay: F(2, 14) = 7.699, p < 0.01, Drug: F(1, 7) = 8.498, p < 0.05. 5 s vs 30 s: p < 0.05"]
[null,"Right: Two-way repeated measures ANOVA, n = 9, Delay x Drug interaction: F(2, 14) = 0.398, p = 0.679, Delay: F(2, 14) = 0.297, p = 0.748, Drug: F(1, 7) = 16.568, p < 0.01."]
["Fig. 2K","Two-way ANOVA, Chronic saline: n = 8, Chronic PCP: n = 9. Δ % correct response:  Delay x Group interaction: F(2, 30) = 0.586, p = 0.563, Delay: F(2, 30) = 0.121, p = 0.886, Group: F(1, 15) = 27.591, p < 0.001."]
["Fig. 4C","One-way ANOVA followed by Dunnett T3 post hoc test, SAL-VEH: n = 16, PCP-VEH: n = 15, PCP-HAL: n = 12, PCP-OLZ: n = 15, Distance: F(3, 57) = 8.476, p < 0.01, PCP-VEH vs SAL-VEH: p < 0.05, PCP-HAL vs SAL-VEH: p = 0.119, PCP-VEH vs PCP-OLZ: p < 0.01"]
["Fig. 4E","NAc core: One-way ANOVA followed by Dunnett T3 post hoc test, SAL-VEH: n = 4, PCP-VEH: n = 4, PCP-OLZ: n = 4, Distance: F(2, 11) = 4.490, p = 0.044, PCP-VEH vs SAL-VEH: p = 0.196, PCP-VEH vs PCP-OLZ: p = 0.264."]
[null,"NAc shell: One-way ANOVA followed by Dunnett T3 post hoc test, Distance: F(2, 11) = 22.871, p < 0.001, PCP-VEH vs SAL-VEH: p < 0.05, PCP-VEH vs PCP-OLZ: p < 0.05."]
["Fig. 4G","Two-way ANOVA, SAL-VEH: n = 8, SAL-OLZ: n = 10, PCP-VEH: n = 8, PCP-OLZ: n = 8. Days to reach criterion:  Model x Treatment interaction: F(1, 30) = 0.275, p = 0.604, Model: F(1, 30) = 1.770, p = 0.193, Treatment: F(1, 30) = 0.787, p = 0.382."]
["Fig. 4H","Two-way ANOVA, SAL-VEH: n = 8, SAL-OLZ: n = 10, PCP-VEH: n = 8, PCP-OLZ: n = 8. Percent correct responses:  Model x Treatment interaction: F(1, 30) = 2.974, p = 0.095, Model: F(1, 30) = 0.794, p = 0.380, Treatment: F(1, 30) = 1.458, p = 0.237."]
["Fig. 4I","Three-way repeated measures ANOVA followed by Bonferroni post hoc test, SAL-VEH: n = 8, PCP-VEH: n = 8, PCP-OLZ: n = 8, Delay x Model x Treatment interaction: F(1.574, 47.227) = 0.228, p = 0.743, Delay x Model interaction: F(1.574, 47.227) = 1.398, p = 0.255, Delay x Treatment interaction: F(1.574, 47.227) = 1.008, p = 0.356, Delay: F(1.574, 47.227) = 12.380, p < 0.001, Model: F(1, 30) = 12.193, p < 0.01, Treatment: F(1, 30) = 0.102, p = 0.752."]
["Fig. 4L","Two-way ANOVA followed by Bonferroni post hoc test, SAL-VEH: n = 4, SAL-OLZ: n = 4, PCP-VEH: n = 4, PCP-OLZ: n = 4."]
[null,"Intensity: Model x Treatment interaction: F(1, 12) = 3.916, p = 0.071, Model: F(1, 12) = 2.869, p = 0.116, Treatment: F(1, 12) = 4.045, p = 0.067."]
[null,"Density: Model x Treatment interaction: F(1, 12) = 0.577, p = 0.462, Model: F(1, 12) = 4.807, p < 0.05, Treatment: F(1, 12) = 1.877, p = 0.196."]
[null,"Size: Model x Treatment interaction: F(1, 12) = 3.916, p = 0.071, Model: F(1, 12) = 0.035, p = 0.855, Treatment: F(1, 12) = 0.017, p = 0.898."]
["Fig. 4M","Two-way ANOVA followed by Bonferroni post hoc test, SAL-VEH: n = 4, SAL-OLZ: n = 4, PCP-VEH: n = 4, PCP-OLZ: n = 4."]
[null,"Intensity: Model x Treatment interaction: F(1, 12) = 1.017, p = 0.333, Model: F(1, 12) = 8.131, p < 0.05, Treatment: F(1, 12) = 1.022, p = 0.332."]
[null,"Per soma: Model x Treatment interaction: F(1, 12) = 0.021, p = 0.887, Model: F(1, 12) = 26.950, p < 0.001, Treatment: F(1, 12) = 4.067, p = 0.067."]
[null,"Size: Model x Treatment interaction: F(1, 12) = 0.225, p = 0.643, Model: F(1, 12) = 16.261, p < 0.01, Treatment: F(1, 12) = 0.028, p = 0.871."]
["Fig. 5D","mCherry: Two-way repeated measures ANOVA, n = 7, Delay x Drug interaction: F(2, 12) = 0.475, p = 0.633, Delay: F(2, 12) = 1.779, p = 0.210, Drug: F(1, 6) = 0.077, p = 0.791."]
[null,"hM3D(Gq)-mCherry: Two-way repeated measures ANOVA, n = 8, Delay x Drug interaction: F(2, 14) = 1.790, p = 0.203, Delay: F(2, 14) = 1.208, p = 0.328, Drug: F(1, 7) = 44.569, p < 0.001."]
["Fig. 5E","Two-way ANOVA, mCherry: n = 7, hM3D(Gq)-mCherry: n = 8. Δ % correct response:  Delay x Group interaction: F(2, 26) = 0.046, p = 0.955, Delay: F(2, 26) = 2.037, p = 0.151, Group: F(1, 13) = 5.665, p < 0.05."]
["Supplemental Fig. S1A","Left: Student’s t-test, Saline: n = 5, PCP: n = 5, t(8) = 0.351, p = 0.735."]
[null,"Right: Two-way ANOVA followed by Bonferroni post hoc test, Model: F(1, 24) = 1.939, p = 0.177, Spine type: F(2, 24) = 683.451, p < 0.001, Model x Spine type interaction: F(2, 24) = 1.395, p = 0.267, Thin vs. Mushroom: p < 0.001, Thin vs. Stubby: p < 0.001, Mushroom vs. Stubby: p < 0.001."]
["Supplemental Fig. S1B","Left: Student’s t-test. t(8) = 0.885, p = 0.402. Saline: n = 5, PCP: n = 5"]
[null,"Right: Two-way ANOVA followed by Bonferroni post hoc test, Model: F(1, 24) = 0.221, p = 0.642, Spine type: F(2, 24) = 452.660, p < 0.001, Model x Spine type interaction: F(2, 24) = 2.800, p = 0.081, Thin vs. Mushroom: p < 0.001, Thin vs. Stubby: p < 0.001, Mushroom vs. Stubby: p < 0.001."]
["Supplemental Fig. S1C","Left: Student’s t-test, Saline: n = 5, PCP: n = 5, t(8) = 0.337, p = 0.745."]
[null,"Right: Two-way ANOVA followed by Bonferroni post hoc test, Model: F(1, 24) = 0.476, p = 0.497, Spine type: F(2, 24) = 836.951, p < 0.001, Model x Spine type interaction: F(2, 24) = 0.225, p = 0.800, Thin vs. Mushroom: p < 0.001, Thin vs. Stubby: p < 0.001, Mushroom vs. Stubby: p < 0.001."]
["Supplemental Fig. S1D","Left: Student’s t-test, Saline: n = 5, PCP: n = 5, t(8) = 0.148, p = 0.886."]
[null,"Right: Two-way ANOVA followed by Bonferroni post hoc test, Model: F(1, 24) = 1.491, p = 0.234, Spine type: F(2, 24) = 528.342, p < 0.001, Model x Spine type interaction: F(2, 24) = 0.741, p = 0.487, Thin vs. Mushroom: p < 0.001, Thin vs. Stubby: p < 0.001, Mushroom vs. Stubby: p < 0.001."]
["Supplemental Fig. S1E","Left: Student’s t-test, Saline: n = 5, PCP: n = 5, t(8) = 0.079, p = 0.939."]
[null,"Right: Two-way ANOVA followed by Bonferroni post hoc test, Model: F(1, 24) = 0.048, p = 0.828, Spine type: F(2, 24) = 188.915, p < 0.001, Model x Spine type interaction: F(2, 24) = 0.233, p = 0.794, Thin vs. Mushroom: p < 0.001, Thin vs. Stubby: p < 0.001, Mushroom vs. Stubby: p < 0.001."]
["Supplemental Fig. S1F","Left: Student’s t-test, Saline: n = 5, PCP: n = 5, t(8) = 0.244, p = 0.813."]
[null,"Right: Two-way ANOVA followed by Bonferroni post hoc test, Model: F(1, 24) = 1.252, p = 0.274, Spine type: F(2, 24) = 1094.593, p < 0.001, Model x Spine type interaction: F(2, 24) = 0.722, p = 0.496, Thin vs. Mushroom: p < 0.001, Thin vs. Stubby: p < 0.001, Mushroom vs. Stubby: p < 0.001."]
["Supplemental Fig. S3A","Left: Paired t-test, Vehicle: n = 8, DCZ: n = 8, t(7) = -0.794, p = 0.453. Right: Paired t-test, Correct: n = 8, Incorrect: n = 8, t(8) = 1.184, p = 0.275."]
["Supplemental Fig. S3B","Left: Paired t-test, Vehicle: n = 9, DCZ: n = 9, t(8) = 0.846, p = 0.422. Right: Paired t-test, Correct: n = 9, Incorrect: n = 9, t(8) = 2.204, p = 0.059."]
["Supplemental Fig. S4F","Two-way repeated measures ANOVA followed by Bonferroni post hoc test, SAL-VEH: n = 16, PCP-VEH: n = 15, PCP-HAL: n = 12, PCP-OLZ: n = 15, Group x Session interaction: F(9.524, 171.436) = 16.702, p < 0.001."]
[null,"Group in Session 1 (between subject): F(3, 54) = 43.33, p < 0.001, SAL-VEH vs PCP-VEH: p < 0.001, SAL-VEH vs PCP-HAL: p < 0.001, SAL-VEH vs PCP-OLZ: p < 0.001."]
[null,"Session in SAL-VEH (within subject): F(4, 216) = 0.61, p = 0.654."]
[null,"Session in PCP-VEH (within subject): F(4, 216) = 58.12, p < 0.001, Session 4 vs Session 1: p < 0.05, Session 7 vs Session 1: p < 0.001, Session 10 vs Session 1: p < 0.001, Session 13 vs Session 1: p < 0.001."]
[null,"Session in PCP-HAL (within subject): F(4, 216) = 76.36, p < 0.001, Session 4 vs Session 1: p = 0.402, Session 7 vs Session 1: p < 0.001, Session 10 vs Session 1: p < 0.001, Session 13 vs Session 1: p < 0.001."]
[null,"Session in PCP-OLZ (within subject): F(4, 216) = 55.73, p < 0.001, Session 4 vs Session 1: p < 0.001, Session 7 vs Session 1: p < 0.001, Session 10 vs Session 1: p < 0.001, Session 13 vs Session 1: p < 0.001."]
["Supplemental Fig. S5A","Welch’s ANOVA followed by Dunnett T3 post hoc test, SAL-VEH: n = 16, PCP-VEH: n = 15, PCP-HAL: n = 12, PCP-OLZ: n = 15, F(3, 30.293) = 8.183, p < 0.001, SAL-VEH vs PCP-VEH: p < 0.05, PCP-HAL vs PCP-VEH: p = 0.114, PCP-OLZ vs PCP-VEH: p < 0.01."]
["Supplemental Fig. S5B","One-way ANOVA followed by Bonferroni post hoc test, SAL-VEH: n = 16, PCP-VEH: n = 15, PCP-HAL: n = 12, PCP-OLZ: n = 15, F(3, 55) = 6.173, p < 0.01, SAL-VEH vs PCP-VEH: p = 0.065, PCP-HAL vs PCP-VEH: p < 0.01, PCP-OLZ vs PCP-VEH: p < 0.05."]
["Supplemental Fig. S5C","Welch’s ANOVA followed by Dunnett T3 post hoc test, SAL-VEH: n = 16, PCP-VEH: n = 15, PCP-HAL: n = 12, PCP-OLZ: n = 15, F(3, 30.016) = 10.948, p < 0.001, SAL-VEH vs PCP-VEH: p < 0.01, PCP-HAL vs PCP-VEH: p = 0.347, PCP-OLZ vs PCP-VEH: p < 0.001, PCP-OLZ vs PCP-HAL: p < 0.01."]
["Supplemental Fig. S5D","One-way ANOVA followed by Bonferroni post hoc test, SAL-VEH: n = 16, PCP-VEH: n = 15, PCP-HAL: n = 12, PCP-OLZ: n = 15, F(3, 55) = 6.753, p < 0.01, SAL-VEH vs PCP-VEH: p < 0.05, PCP-HAL vs PCP-VEH: p < 0.01, PCP-OLZ vs PCP-VEH: p < 0.05."]
["Supplemental Fig. S6B","Two-way ANOVA followed by Bonferroni post hoc test, SAL-VEH: n = 4, SAL-OLZ: n = 4, PCP-VEH: n = 4, PCP-OLZ: n = 4."]
[null,"Intensity: Model x Treatment interaction: F(1, 12) = 0.132, p = 0.723, Model: F(1, 12) = 2.344, p = 0.152, Treatment: F(1, 12) = 0.556, p = 0.470."]
[null,"Density: Model x Treatment interaction: F(1, 12) = 0.775, p = 0.396, Model: F(1, 12) = 17.162, p < 0.01, Treatment: F(1, 12) = 3.826, p = 0.074."]
["Supplemental Fig. S7A","Student t-test, PCP-OLZ + AAV-hSyn-DIO-mCherry: n = 7, PCP-OLZ + AAV-hSyn-DIO-hM3D(Gq)-mCherry: n = 8, t(13) = 0.130, p = 0.898."]
["Supplemental Fig. S7B","Student t-test, PCP-OLZ + AAV-hSyn-DIO-mCherry: n = 7, PCP-OLZ + AAV-hSyn-DIO-hM3D(Gq)-mCherry: n = 8, t(13) = 2.000, p = 0.067."]
["Supplemental Fig. S8A","AAV-hSyn-DIO-mCherry: Paired t-test. t(6) = 1.606, p = 0.159. Vehicle: n = 7, DCZ: n = 7."]
[null,"AAV-hSyn-DIO-hM3D(Gq)-mCherry: Paired t-test. t(7) = 1.083, p = 0.315. Vehicle: n = 8, DCZ: n = 8."]
["Supplemental Fig. S8B","AAV-hSyn-DIO-mCherry: Paired t-test, Vehicle: n = 7, DCZ: n = 7, t(6) = 0.626, p = 0.554."]
[null,"AAV-hSyn-DIO-hM3D(Gq)-mCherry: Paired t-test, Vehicle: n = 8, DCZ: n = 8, t(7) = 0.573, p = 0.584."]
["Supplemental Fig. S9","Student t-test, PCP-OLZ + AAV-hSyn-DIO-mCherry: n = 7, PCP-OLZ + AAV-hSyn-DIO-hM3D(Gq)-mCherry: n = 8, 5 s: t(13) = -1.88, p = 0.082, 15 s: t(13) = 0.506, p = 0.621, 30 s: t(13) = -0.13, p = 0.902."]
["Supplemental Fig. S10E","Student t-test, PCP-OLZ + AAV-hSyn-DIO-mCherry: n = 6, PCP-OLZ + AAV-hSyn-DIO-hM3D(Gq)-mCherry: n = 7, t(11) = 0.036, p = 0.972."]