Table S9: Mutations in H1975-OR cells from whole-exon sequencing.																																																				
CHROM	POS	ID	REF	ALT	QUAL	FILTER	GeneName	Func	Gene	GeneDetail	ExonicFunc	AAChange	Genecode27	wgRna	cytoBand	targetScanS	tfbsConsSites	genomicSuperDups	Repeat	avsnp150	cosmic82	clinvar_20170905	gwasCatalognew	1000g2015aug_Chinese	1000g2015aug_eas	1000g2015aug_all	esp6500siv2_all	ExAC_ALL	ExAC_EAS	SIFT	Polyphen2_HVAR	Polyphen2_HDIV	MutationTaster	gerp++gt2	CADD	INFO	FORMAT	OR_1975	Ori_REF	Ori_ALT	shared_hom	shared_het	OMIM	GWAS_Pubmed_pValue	HGMD_ID_Diseasename	GO_BP	GO_CC	GO_MF	KEGG_PATHWAY	PID_PATHWAY	BIOCARTA_PATHWAY	REACTOME_PATHWAY
7	55086755	rs712829	G	T	187.9	PASS	EGFR	UTR5	"NM_005228,NM_201282,NM_201283,NM_201284"	NM_005228:c.-216G>T;NM_201282:c.-216G>T;NM_201283:c.-216G>T;NM_201284:c.-216G>T	.	.	"ENST00000342916.7_1,ENST00000455089.5_1,ENST00000420316.6_1,ENST00000344576.6_1,ENST00000454757.6_1"	.	7p11.2	.	.	.	.	rs712829	ID=COSN6596408;OCCURENCE=1(central_nervous_system)	Likely benign;Lung_cancer;RCV000368694.1;MedGen:OMIM:SNOMED_CT;C0684249:211980:187875007	.	0.0598007	0.0585	0.226438	.	.	.	.	.	.	.	.	"2.141580,13.12"	AC=2;AF=1;AN=2;DP=4;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=24.11;SOR=1.609	GT:AD:DP:GQ:PL	"1/1:0,4:4:15:216,15,0"	G	T	1	0	.	NA	.	.	.	.	.	.	.	.
7	55086780	rs712830	A	C	148.03	PASS	EGFR	UTR5	"NM_005228,NM_201282,NM_201283,NM_201284"	NM_005228:c.-191A>C;NM_201282:c.-191A>C;NM_201283:c.-191A>C;NM_201284:c.-191A>C	.	.	"ENST00000455089.5_1,ENST00000342916.7_1,ENST00000454757.6_1,ENST00000344576.6_1,ENST00000420316.6_1"	.	7p11.2	.	.	.	.	rs712830	.	Likely benign;Lung_cancer;RCV000262345.1;MedGen:OMIM:SNOMED_CT;C0684249:211980:187875007	.	0.996678	0.998	0.929712	.	.	.	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=4;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=34.07;SOR=3.258	GT:AD:DP:GQ:PL	"1/1:0,4:4:12:176,12,0"	A	C	1	0	.	NA	.	.	.	.	.	.	.	.
7	55211316	rs4947984	G	A	439.77	PASS	EGFR	intronic	"NM_005228,NM_201282,NM_201283,NM_201284"	.	.	.	"ENST00000420316.6_1,ENST00000275493.6_1,ENST00000344576.6_1,ENST00000450046.1_1,ENST00000454757.6_1,ENST00000342916.7_1,ENST00000455089.5_1"	.	7p11.2	.	.	.	.	rs4947984	ID=COSN17139493;OCCURENCE=1(soft_tissue)	.	.	0.00166113	0.001	0.0461262	.	.	.	.	.	.	.	.	.	AC=1;AF=0.5;AN=2;BaseQRankSum=2.987;ClippingRankSum=0;DP=19;ExcessHet=3.0103;FS=0;MLEAC=1;MLEAF=0.5;MQ=60;MQRankSum=0;QD=23.15;ReadPosRankSum=0.069;SOR=1.609	GT:AD:DP:GQ:PL	"0/1:6,13:19:99:468,0,169"	G	A	0	1	.	NA	.	.	.	.	.	.	.	.
7	55214188	rs17289672	T	C	284.77	PASS	EGFR	intronic	"NM_005228,NM_201282,NM_201283,NM_201284"	.	.	.	"ENST00000454757.6_1,ENST00000344576.6_1,ENST00000450046.1_1,ENST00000275493.6_1,ENST00000420316.6_1,ENST00000455089.5_1,ENST00000342916.7_1"	.	7p11.2	.	.	.	.	rs17289672	ID=COSN17141419;OCCURENCE=1(soft_tissue)	.	.	0	.	0.014976	.	.	.	.	.	.	.	2.29	.	AC=1;AF=0.5;AN=2;BaseQRankSum=2.361;ClippingRankSum=0;DP=36;ExcessHet=3.0103;FS=2.808;MLEAC=1;MLEAF=0.5;MQ=60;MQRankSum=0;QD=7.91;ReadPosRankSum=-0.333;SOR=0.177	GT:AD:DP:GQ:PL	"0/1:25,11:36:99:313,0,862"	T	C	0	1	.	NA	.	.	.	.	.	.	.	.
7	55220177	rs11506105	A	G	1272.77	PASS	EGFR	intronic	"NM_005228,NM_201282,NM_201283,NM_201284"	.	.	.	"ENST00000344576.6_1,ENST00000454757.6_1,ENST00000420316.6_1,ENST00000275493.6_1,ENST00000342916.7_1,ENST00000455089.5_1,ENST00000638463.1_1"	.	7p11.2	.	.	.	.	rs11506105	"ID=COSN17139929,COSN17139048,COSN17137124,COSN17145694,COSN17147475,COSN17146608,COSN17144794,COSN17132755,COSN17133586,COSN17138123,COSN15322395,COSN17143812,COSN17152138,COSN17148376,COSN17143063,COSN17149278,COSN19657093,COSN17134411,COSN17151080,COSN17150181,COSN17140779,COSN17141714,COSN5852733;OCCURENCE=1(lung),1(oesophagus),1(haematopoietic_and_lymphoid_tissue),20(soft_tissue)"	.	.	0.38206	0.3502	0.550919	.	.	.	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=46;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=28.28;SOR=4.271	GT:AD:DP:GQ:PL	"1/1:0,45:45:99:1301,135,0"	A	G	1	0	.	NA	.	.	.	.	.	.	.	.
7	55223790	rs3735059	T	C	814.77	PASS	EGFR	intronic	"NM_005228,NM_201282,NM_201283,NM_201284"	.	.	.	"ENST00000342916.7_1,ENST00000455089.5_1,ENST00000638463.1_1,ENST00000344576.6_1,ENST00000454757.6_1,ENST00000420316.6_1,ENST00000275493.6_1"	.	7p11.2	.	.	.	.	rs3735059	.	.	.	0.388704	0.3542	0.594249	.	.	.	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=20;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=31.55;SOR=6.091	GT:AD:DP:GQ:PL	"1/1:0,20:20:60:843,60,0"	T	C	1	0	.	NA	.	.	.	.	.	.	.	.
7	55225170	rs4947987	G	C	548.77	PASS	EGFR	intronic	"NM_005228,NM_201282,NM_201284"	.	.	.	"ENST00000638463.1_1,ENST00000455089.5_1,ENST00000342916.7_1,ENST00000454757.6_1,ENST00000344576.6_1,ENST00000275493.6_1"	.	7p11.2	.	.	.	.	rs4947987	.	.	.	1	1	0.91254	.	.	.	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=15;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=29.03;SOR=4.047	GT:AD:DP:GQ:PL	"1/1:0,15:15:45:577,45,0"	G	C	1	0	.	NA	.	.	.	.	.	.	.	.
7	55228053	rs1558544	A	T	2455.77	PASS	EGFR	intronic	"NM_005228,NM_201282,NM_201284"	.	.	.	"ENST00000455089.5_1,ENST00000638463.1_1,ENST00000342916.7_1,ENST00000454757.6_1,ENST00000344576.6_1,ENST00000275493.6_1"	.	7p11.2	.	.	.	.	rs1558544	.	.	.	0.996678	0.997	0.773363	0.6634	0.7697	0.9974	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=73;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=34.11;SOR=1.675	GT:AD:DP:GQ:PL	"1/1:0,72:72:99:2484,216,0"	A	T	1	0	.	NA	.	.	.	.	.	.	.	.
7	55228173	rs759162	C	T	484.77	PASS	EGFR	intronic	"NM_005228,NM_201282,NM_201284"	.	.	.	"ENST00000275493.6_1,ENST00000454757.6_1,ENST00000344576.6_1,ENST00000638463.1_1,ENST00000455089.5_1,ENST00000342916.7_1"	.	7p11.2	.	.	.	.	rs759162	.	.	.	0.996678	0.997	0.81869	.	.	.	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=15;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=34.63;SOR=5.421	GT:AD:DP:GQ:PL	"1/1:0,14:14:42:513,42,0"	C	T	1	0	.	NA	.	.	.	.	.	.	.	.
7	55233089	rs17290169	C	T	3628.77	PASS	EGFR	exonic	"NM_005228,NM_201282,NM_201284"	.	synonymous SNV	"EGFR:NM_005228:exon15:c.C1839T:p.A613A,EGFR:NM_201282:exon15:c.C1839T:p.A613A,EGFR:NM_201284:exon15:c.C1839T:p.A613A"	"ENST00000638463.1_1,ENST00000455089.5_1,ENST00000342916.7_1,ENST00000275493.6_1,ENST00000454757.6_1,ENST00000344576.6_1"	.	7p11.2	.	.	.	.	rs17290169	"ID=COSM5019978,COSM5019977,COSM5019979;OCCURENCE=2(soft_tissue)"	Likely benign|Benign;Lung_cancer|not_specified;RCV000394040.1|RCV000454959.1;MedGen:OMIM:SNOMED_CT|MedGen;C0684249:211980:187875007|CN169374	.	0.00166113	0.001	0.0421326	0.0581	0.0512	0.0006	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=111;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=32.69;SOR=1.089	GT:AD:DP:GQ:PL	"1/1:0,111:111:99:3657,333,0"	C	T	1	0	.	NA	.	.	.	.	.	.	.	.
7	55233185	rs17290183	C	T	1801.77	PASS	EGFR	intronic	"NM_005228,NM_201282,NM_201284"	.	.	.	"ENST00000638463.1_1,ENST00000455089.5_1,ENST00000342916.7_1,ENST00000275493.6_1,ENST00000454757.6_1,ENST00000344576.6_1"	.	7p11.2	.	.	.	.	rs17290183	"ID=COSN17141055,COSN17139320;OCCURENCE=2(soft_tissue)"	.	.	0.00166113	0.001	0.0421326	.	.	.	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=52;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=34.65;SOR=3.528	GT:AD:DP:GQ:PL	"1/1:0,52:52:99:1830,156,0"	C	T	1	0	.	NA	.	.	.	.	.	.	.	.
7	55236774	rs845550	A	G	49.74	PASS	EGFR	intronic	"NM_005228,NM_201284"	.	.	.	"ENST00000638463.1_1,ENST00000455089.5_1,ENST00000454757.6_1,ENST00000344576.6_1,ENST00000275493.6_1"	.	7p11.2	.	.	.	.	rs845550	.	.	.	1	1	0.932109	.	.	.	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=2;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=24.87;SOR=0.693	GT:AD:DP:GQ:PL	"1/1:0,2:2:6:77,6,0"	A	G	1	0	.	NA	.	.	.	.	.	.	.	.
7	55237283	rs845551	A	G	123.03	PASS	EGFR	intronic	"NM_005228,NM_201284"	.	.	.	"ENST00000275493.6_1,ENST00000454757.6_1,ENST00000344576.6_1,ENST00000455089.5_1,ENST00000638463.1_1"	.	7p11.2	.	.	.	.	rs845551	.	.	.	0.586379	0.631	0.656949	.	.	.	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=4;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=30.76;SOR=0.693	GT:AD:DP:GQ:PL	"1/1:0,4:4:12:151,12,0"	A	G	1	0	.	NA	.	.	.	.	.	.	.	.
7	55237601	rs17290197	C	A	108.94	PASS	EGFR	intronic	"NM_005228,NM_201284"	.	.	.	"ENST00000344576.6_1,ENST00000454757.6_1,ENST00000275493.6_1,ENST00000638463.1_1,ENST00000455089.5_1"	.	7p11.2	.	.	.	.	rs17290197	"ID=COSN17139134,COSN17140862;OCCURENCE=2(soft_tissue)"	.	.	0.00166113	0.001	0.028155	.	.	.	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=5;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=21.79;SOR=1.981	GT:AD:DP:GQ:PL	"1/1:0,5:5:14:137,14,0"	C	A	1	0	.	NA	.	.	.	.	.	.	.	.
7	55238147	rs17336988	G	A	484.77	PASS	EGFR	exonic	NM_201284	.	synonymous SNV	EGFR:NM_201284:exon16:c.G2028A:p.P676P	"ENST00000638463.1_1,ENST00000455089.5_1,ENST00000275493.6_1,ENST00000454757.6_1,ENST00000344576.6_1"	.	7p11.2	.	.	.	.	rs17336988	ID=COSM5020153;OCCURENCE=1(soft_tissue)	.	.	0	.	0.00758786	0.015	0.0125	0	.	.	.	.	.	.	AC=1;AF=0.5;AN=2;BaseQRankSum=5.347;ClippingRankSum=0;DP=87;ExcessHet=3.0103;FS=5.128;MLEAC=1;MLEAF=0.5;MQ=60;MQRankSum=0;QD=5.57;ReadPosRankSum=-1.895;SOR=0.645	GT:AD:DP:GQ:PL	"0/1:67,20:87:99:513,0,1736"	G	A	0	1	.	NA	.	.	.	.	.	.	.	.
7	55238253	rs17290225	G	A	1929.77	PASS	EGFR	UTR3	NM_201284	NM_201284:c.*16G>A	.	.	"ENST00000454757.6_1,ENST00000344576.6_1,ENST00000275493.6_1,ENST00000455089.5_1,ENST00000638463.1_1"	.	7p11.2	.	.	.	.	rs17290225	"ID=COSN17139497,COSN17141213;OCCURENCE=2(soft_tissue)"	.	.	0.00166113	0.001	0.0249601	0.0411	0.0373	0.0003	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=58;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=33.27;SOR=1.609	GT:AD:DP:GQ:PL	"1/1:0,58:58:99:1958,173,0"	G	A	1	0	.	NA	.	.	.	.	.	.	.	.
7	55238268	rs10228436	G	A	1818.77	PASS	EGFR	UTR3	NM_201284	NM_201284:c.*31G>A	.	.	"ENST00000275493.6_1,ENST00000344576.6_1,ENST00000454757.6_1,ENST00000638463.1_1,ENST00000455089.5_1"	.	7p11.2	.	.	.	.	rs10228436	.	.	.	0.48505	0.5357	0.376198	0.3051	0.367	0.5421	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=59;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=30.83;SOR=1.649	GT:AD:DP:GQ:PL	"1/1:0,59:59:99:1847,176,0"	G	A	1	0	.	NA	.	.	.	.	.	.	.	.
7	55238464	rs10277413	T	G	124.03	PASS	EGFR	UTR3	NM_201284	NM_201284:c.*227T>G	.	.	"ENST00000455089.5_1,ENST00000638463.1_1,ENST00000344576.6_1,ENST00000454757.6_1,ENST00000275493.6_1"	.	7p11.2	.	.	.	.	rs10277413	.	.	.	0.48505	0.5347	0.376797	.	.	.	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=4;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=31.01;SOR=1.609	GT:AD:DP:GQ:PL	"1/1:0,4:4:12:152,12,0"	T	G	1	0	.	NA	.	.	.	.	.	.	.	.
7	55238874	rs2227984	T	A	3382.77	PASS	EGFR	exonic	NM_005228	.	synonymous SNV	EGFR:NM_005228:exon16:c.T1887A:p.T629T	"ENST00000638463.1_1,ENST00000455089.5_1,ENST00000275493.6_1,ENST00000454757.6_1"	.	7p11.2	.	.	.	.	rs2227984	"ID=COSM5830714,COSM3762772;OCCURENCE=1(large_intestine),1(breast)"	Benign|Likely benign;not_specified|Lung_cancer;RCV000248349.1|RCV000356745.1;MedGen|MedGen:OMIM:SNOMED_CT;CN169374|C0684249:211980:187875007	.	0.48505	0.5347	0.390375	0.3225	0.374	0.5412	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=97;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=29.75;SOR=0.693	GT:AD:DP:GQ:PL	"1/1:0,96:96:99:3411,289,0"	T	A	1	0	.	NA	.	.	.	.	.	.	.	.
7	55241510	rs17337100	C	A	328.77	PASS	EGFR	intronic	NM_005228	.	.	.	"ENST00000638463.1_1,ENST00000455089.5_1,ENST00000275493.6_1,ENST00000454757.6_1"	.	7p11.2	.	.	.	.	rs17337100	"ID=COSN17140864,COSN17139136;OCCURENCE=2(soft_tissue)"	.	.	0.00166113	0.001	0.0409345	.	.	.	.	.	.	.	2.22	.	AC=1;AF=0.5;AN=2;BaseQRankSum=4.386;ClippingRankSum=0;DP=40;ExcessHet=3.0103;FS=0;MLEAC=1;MLEAF=0.5;MQ=60;MQRankSum=0;QD=8.22;ReadPosRankSum=2.349;SOR=0.368	GT:AD:DP:GQ:PL	"0/1:28,12:40:99:357,0,909"	C	A	0	1	.	NA	.	.	.	.	.	.	.	.
7	55241836	rs17290336	C	T	559.77	PASS	EGFR	intronic	NM_005228	.	.	.	"ENST00000455089.5_1,ENST00000638463.1_1,ENST00000454757.6_1,ENST00000275493.6_1"	.	7p11.2	.	.	.	.	rs17290336	"ID=COSN17141057,COSN17139322;OCCURENCE=2(soft_tissue)"	.	.	0.00166113	0.001	0.04373	.	.	.	.	.	.	.	.	.	AC=1;AF=0.5;AN=2;BaseQRankSum=-4.008;ClippingRankSum=0;DP=50;ExcessHet=3.0103;FS=0;MLEAC=1;MLEAF=0.5;MQ=60;MQRankSum=0;QD=11.2;ReadPosRankSum=0.595;SOR=0.598	GT:AD:DP:GQ:PL	"0/1:30,20:50:99:588,0,1052"	C	T	0	1	.	NA	.	.	.	.	.	.	.	.
7	55242638	rs17290378	T	C	841.77	PASS	EGFR	intronic	NM_005228	.	.	.	"ENST00000454757.6_1,ENST00000275493.6_1,ENST00000638463.1_1,ENST00000455089.5_1"	.	7p11.2	.	.	.	.	rs17290378	"ID=COSN17141420,COSN17139721;OCCURENCE=2(soft_tissue)"	.	.	0.00166113	0.001	0.0389377	.	.	.	.	.	.	.	.	.	AC=1;AF=0.5;AN=2;BaseQRankSum=-5.747;ClippingRankSum=0;DP=175;ExcessHet=3.0103;FS=3.882;MLEAC=1;MLEAF=0.5;MQ=60;MQRankSum=0;QD=4.81;ReadPosRankSum=0.307;SOR=0.398	GT:AD:DP:GQ:PL	"0/1:125,50:175:99:870,0,3874"	T	C	0	1	.	NA	.	.	.	.	.	.	.	.
7	55242782	rs712831	T	C	651.77	PASS	EGFR	intronic	NM_005228	.	.	.	"ENST00000275493.6_1,ENST00000454757.6_1,ENST00000455089.5_1,ENST00000638463.1_1"	.	7p11.2	.	.	.	"Score=273;Name=""4320918:MIRb(SINE)"""	rs712831	.	.	.	0.596346	0.6329	0.672524	.	.	.	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=23;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=28.34;SOR=6.358	GT:AD:DP:GQ:PL	"1/1:0,23:23:69:680,69,0"	T	C	1	0	.	NA	.	.	.	.	.	.	.	.
7	55248787	rs10241326	T	C	1589.77	PASS	EGFR-AS1	ncRNA_exonic	NR_047551	.	.	.	"ENST00000638463.1_1,ENST00000455089.5_1,ENST00000454757.6_1,ENST00000275493.6_1,ENST00000442411.1_1"	.	7p11.2	.	.	.	.	rs10241326	.	.	.	0.19103	0.1815	0.495407	.	.	.	.	.	.	.	.	.	AC=1;AF=0.5;AN=2;BaseQRankSum=-6.487;ClippingRankSum=0;DP=69;ExcessHet=3.0103;FS=0;MLEAC=1;MLEAF=0.5;MQ=60;MQRankSum=0;QD=23.38;ReadPosRankSum=-1.63;SOR=1.981	GT:AD:DP:GQ:PL	"0/1:19,49:68:99:1618,0,574"	T	C	0	1	.	NA	.	.	.	.	.	.	.	.
7	55249063	rs1050171	G	A	11566.8	PASS	EGFR	exonic	NM_005228	.	synonymous SNV	EGFR:NM_005228:exon20:c.G2361A:p.Q787Q	"ENST00000454757.6_1,ENST00000442411.1_1,ENST00000275493.6_1,ENST00000455089.5_1,ENST00000638463.1_1"	.	7p11.2	.	.	.	.	rs1050171	"ID=COSM1451600;OCCURENCE=7(lung),2(breast),1(haematopoietic_and_lymphoid_tissue)"	Benign|Likely benign;not_specified|Lung_cancer;RCV000038427.3|RCV000321080.1;MedGen|MedGen:OMIM:SNOMED_CT;CN169374|C0684249:211980:187875007	.	0.19103	0.1825	0.432708	0.5424	0.5228	0.1642	.	.	.	.	4.86	"3.367041,17.35"	AC=1;AF=0.5;AN=2;BaseQRankSum=-4.687;ClippingRankSum=0;DP=421;ExcessHet=3.0103;FS=2.643;MLEAC=1;MLEAF=0.5;MQ=60;MQRankSum=0;QD=27.54;ReadPosRankSum=1.096;SOR=0.715	GT:AD:DP:GQ:PL	"0/1:133,287:420:99:11595,0,7067"	G	A	0	1	.	NA	.	.	.	.	.	.	.	.
7	55249071	rs121434569	C	T	11682.8	PASS	EGFR	exonic	NM_005228	.	missense SNV	EGFR:NM_005228:exon20:c.C2369T:p.T790M	"ENST00000454757.6_1,ENST00000275493.6_1,ENST00000442411.1_1,ENST00000455089.5_1,ENST00000638463.1_1"	.	7p11.2	.	.	.	.	rs121434569	"ID=COSM6240;OCCURENCE=3(breast),2(upper_aerodigestive_tract),1(soft_tissue),1(central_nervous_system),1(biliary_tract),292(lung)"	"other|drug response|other|drug response|drug response|Likely pathogenic;Nonsmall_cell_lung_cancer,_resistance_to_tyrosine_kinase_inhibitor_in|Tyrosine_kinase_inhibitor_response|Non-small_cell_lung_cancer|gefitinib_response_-_Efficacy|erlotinib_response_-_Efficacy|Lung_cancer;RCV000018088.29|RCV000154232.1|RCV000154233.2|RCV000211140.1|RCV000211319.1|RCV000425417.1;MedGen|MedGen|MeSH:MedGen:SNOMED_CT|MedGen|MedGen|MedGen:OMIM:SNOMED_CT;C4016033|CN225347|D002289:C0007131:254637007|CN236558|CN236552|C0684249:211980:187875007"	.	.	.	.	.	4.12E-05	0	"0.003,D"	"1.0,D"	"1.0,D"	"1,A"	5.92	"5.055662,30"	AC=1;AF=0.5;AN=2;BaseQRankSum=4.548;ClippingRankSum=0;DP=434;ExcessHet=3.0103;FS=3.53;MLEAC=1;MLEAF=0.5;MQ=60;MQRankSum=0;QD=26.98;ReadPosRankSum=1.695;SOR=0.729	GT:AD:DP:GQ:PL	"0/1:136,297:433:99:11711,0,7160"	C	T	0	1	.	NA	.	.	.	.	.	.	.	.
7	55259515	rs121434568	T	G	1297.77	PASS	EGFR	exonic	NM_005228	.	missense SNV	EGFR:NM_005228:exon21:c.T2573G:p.L858R	"ENST00000455089.5_1,ENST00000638463.1_1,ENST00000275493.6_1,ENST00000454757.6_1"	.	7p11.2	.	Score=793;Name=V$GFI1_01	.	.	rs121434568	"ID=COSM6224;OCCURENCE=1(prostate),12(breast),6(thyroid),2(large_intestine),1(upper_aerodigestive_tract),1(peritoneum),1(stomach),1(thymus),2304(lung),1(ovary)"	"drug response|drug response|drug response|drug response|drug response|drug response|Likely pathogenic|Pathogenic;Nonsmall_cell_lung_cancer,_response_to_tyrosine_kinase_inhibitor_in,_somatic|Adenocarcinoma_of_lung,_response_to_tyrosine_kinase_inhibitor_in,_somatic|Tyrosine_kinase_inhibitor_response|carboplatin,_docetaxel,_erlotinib,_gemcitabine,_and_paclitaxel_response_-_Efficacy|gefitinib_response_-_Efficacy|erlotinib_response_-_Efficacy|Adenocarcinoma_of_lung|Non-small_cell_lung_cancer;RCV000018083.87|RCV000018084.61|RCV000150629.1|RCV000211235.1|RCV000211323.1|RCV000211410.1|RCV000418019.1|RCV000435684.1;MedGen|MedGen|MedGen|MedGen|MedGen|MedGen|MeSH:MedGen|MeSH:MedGen:SNOMED_CT;C4016032|C1851577|CN225347|CN236471|CN236558|CN236552|C538231:C0152013|D002289:C0007131:254637007"	.	.	.	.	.	.	.	"0.0,D"	"0.999,D"	"1.0,D"	"1,D"	5.71	"4.601026,25.1"	AC=1;AF=0.5;AN=2;BaseQRankSum=-1.688;ClippingRankSum=0;DP=87;ExcessHet=3.0103;FS=0;MLEAC=1;MLEAF=0.5;MQ=60;MQRankSum=0;QD=14.92;ReadPosRankSum=-0.935;SOR=0.781	GT:AD:DP:GQ:PL	"0/1:36,51:87:99:1326,0,918"	T	G	0	1	.	NA	.	.	.	.	.	.	.	.
7	55259763	rs6970262	A	G	98.77	PASS	EGFR	intronic	NM_005228	.	.	.	"ENST00000454757.6_1,ENST00000275493.6_1,ENST00000455089.5_1,ENST00000638463.1_1"	.	7p11.2	.	.	.	.	rs6970262	.	.	.	0.88206	0.87	0.745807	.	.	.	.	.	.	.	.	.	AC=1;AF=0.5;AN=2;BaseQRankSum=-1.834;ClippingRankSum=0;DP=6;ExcessHet=3.0103;FS=0;MLEAC=1;MLEAF=0.5;MQ=60;MQRankSum=0;QD=16.46;ReadPosRankSum=0;SOR=1.329	GT:AD:DP:GQ:PL	"0/1:2,4:6:65:127,0,65"	A	G	0	1	.	NA	.	.	.	.	.	.	.	.
7	55266417	rs1140475	T	C	1133.77	PASS	EGFR	exonic	NM_005228	.	synonymous SNV	EGFR:NM_005228:exon23:c.T2709C:p.T903T	"ENST00000485503.1_1,ENST00000454757.6_1,ENST00000275493.6_1,ENST00000638463.1_1,ENST00000455089.5_1"	.	7p11.2	.	.	.	.	rs1140475	.	.	.	0.931894	0.9196	0.916733	0.8891	0.8957	0.9266	.	.	.	.	.	.	AC=1;AF=0.5;AN=2;BaseQRankSum=-2.9;ClippingRankSum=0;DP=67;ExcessHet=3.0103;FS=0;MLEAC=1;MLEAF=0.5;MQ=60;MQRankSum=0;QD=16.92;ReadPosRankSum=0.814;SOR=0.656	GT:AD:DP:GQ:PL	"0/1:21,46:67:99:1162,0,522"	T	C	0	1	.	NA	.	.	.	.	.	.	.	.
7	55266757	rs2293348	C	T	48.74	PASS	EGFR	intronic	NM_005228	.	.	.	"ENST00000638463.1_1,ENST00000455089.5_1,ENST00000275493.6_1,ENST00000485503.1_1,ENST00000454757.6_1"	.	7p11.2	.	.	.	.	rs2293348	"ID=COSN17146882,COSN17139324,COSN17140209,COSN17134721,COSN17137447,COSN17149567,COSN17135644,COSN17152435,COSN17133036,COSN17142155,COSN17136506,COSN17143307,COSN17151439;OCCURENCE=13(soft_tissue)"	.	.	0.129568	0.13	0.232827	.	.	.	.	.	.	.	.	.	AC=2;AF=1;AN=2;DP=2;ExcessHet=3.0103;FS=0;MLEAC=2;MLEAF=1;MQ=60;QD=24.37;SOR=2.303	GT:AD:DP:GQ:PL	"1/1:0,2:2:6:76,6,0"	C	T	1	0	.	NA	.	.	.	.	.	.	.	.
7	55272826	rs2692456	G	A	766.77	PASS	EGFR	intronic	NM_005228	.	.	.	"ENST00000638463.1_1,ENST00000454757.6_1,ENST00000275493.6_1"	.	7p11.2	.	Score=872;Name=V$IK1_01	.	.	rs2692456	.	.	.	0.915282	0.8988	0.879792	.	.	.	.	.	.	.	.	.	AC=1;AF=0.5;AN=2;BaseQRankSum=1.893;ClippingRankSum=0;DP=34;ExcessHet=3.0103;FS=0;MLEAC=1;MLEAF=0.5;MQ=60;MQRankSum=0;QD=22.55;ReadPosRankSum=-0.258;SOR=0.836	GT:AD:DP:GQ:PL	"0/1:9,25:34:99:795,0,178"	G	A	0	1	.	NA	.	.	.	.	.	.	.	.