ID	Accession	Gene Name	Description	A1	A2	B2	B1	Imputation(A)	Imputation(B)	Keep(A)	Keep(B)	FC(A_B)	pValue(A_B)	Sig(A_B)	FC(B_A)	pValue(B_A)	Sig(B_A)	GO_CC	GO_MF	GO_BP	KEGG
4EBP1_HUMAN	Q13541	EIF4EBP1	Eukaryotic translation initiation factor 4E-binding protein 1	0.04953553	0.153837811	2.55E-05	2.55E-05	0.1016866705	2.55e-005	0.1016866705	2.55e-005	3987.71256862745	0.000000	1	0.000250770330807517	0.000000	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0098978,glutamatergic synapse;GO:0005634,nucleus;GO:0099524,postsynaptic cytosol;GO:0032991,protein-containing complex	GO:0008190,eukaryotic initiation factor 4E binding;GO:0051721,protein phosphatase 2A binding;GO:0030371,translation repressor activity	GO:0071456,cellular response to hypoxia;GO:0000082,G1/S transition of mitotic cell cycle;GO:0030324,lung development;GO:0031333,negative regulation of protein-containing complex assembly;GO:0045947,negative regulation of translational initiation;GO:0045931,positive regulation of mitotic cell cycle;GO:1990928,response to amino acid starvation;GO:0045471,response to ethanol;GO:0002931,response to ischemia;GO:0031929,TOR signaling	hsa:1978,path:hsa03013,RNA transport;hsa:1978,path:hsa04012,ErbB signaling pathway;hsa:1978,path:hsa04066,HIF-1 signaling pathway;hsa:1978,path:hsa04151,PI3K-Akt signaling pathway;hsa:1978,path:hsa04152,AMPK signaling pathway;hsa:1978,path:hsa04150,mTOR signaling pathway;hsa:1978,path:hsa04218,Cellular senescence;hsa:1978,path:hsa04910,Insulin signaling pathway;hsa:1978,path:hsa04211,Longevity regulating pathway;hsa:1978,path:hsa05231,Choline metabolism in cancer;hsa:1978,path:hsa05221,Acute myeloid leukemia;hsa:1978,path:hsa05168,Herpes simplex virus 1 infection;hsa:1978,path:hsa05163,Human cytomegalovirus infection;hsa:1978,path:hsa05165,Human papillomavirus infection;hsa:1978,path:hsa01521,EGFR tyrosine kinase inhibitor resistance
TXD12_HUMAN	O95881	TXNDC12	Thioredoxin domain-containing protein 12	3.241782329	3.932808518	0.280159535	0.075817906	3.5872954235	0.1779887205	3.5872954235	0.1779887205	20.1546222334915	0.003474	1	0.0496164099934492	0.003410	-1	GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen	GO:0015037,peptide disulfide oxidoreductase activity;GO:0019153,protein-disulfide reductase (glutathione) activity	GO:0060548,negative regulation of cell death;GO:1902236,negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	hsa:51060,path:hsa00480,Glutathione metabolism
WDR81_HUMAN	Q562E7	WDR81	WD repeat-containing protein 81	1.719143005	0.499591527	0.940019531	0.813439866	1.109367266	0.8767296985	1.109367266	0.8767296985	1.26534696828227	0.357103	0	0.790297068761717	0.356751	0	GO:0000421,autophagosome membrane;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0031313,extrinsic component of endosome membrane;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005739,mitochondrion	GO:0070530,K63-linked polyubiquitin modification-dependent protein binding;GO:0035014,phosphatidylinositol 3-kinase regulator activity	GO:0035973,aggrephagy;GO:0045022,early endosome to late endosome transport;GO:0007005,mitochondrion organization;GO:0010923,negative regulation of phosphatase activity;GO:0050821,protein stabilization;GO:0043551,regulation of phosphatidylinositol 3-kinase activity;GO:0006511,ubiquitin-dependent protein catabolic process	
ETFA_HUMAN	P13804	ETFA	Electron transfer flavoprotein subunit alpha, mitochondrial	3.794026217	7.142951147	5.45296457	3.434135142	5.468488682	4.443549856	5.468488682	4.443549856	1.23065766317802	0.365881	0	0.812573658719698	0.365545	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0009055,electron transfer activity;GO:0050660,flavin adenine dinucleotide binding;GO:0016491,oxidoreductase activity	GO:0033539,fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0022904,respiratory electron transport chain	
AN13A_HUMAN	Q8IZ07	ANKRD13A	Ankyrin repeat domain-containing protein 13A	0.068049567	0.058582828	0.117134663	0.109150914	0.0633161975	0.1131427885	0.0633161975	0.1131427885	0.559613196204723	0.280009	0	1.78694856872919	0.280311	0	GO:0005737,cytoplasm;GO:0005770,late endosome;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0016020,membrane	GO:0140036,ubiquitin-dependent protein binding	GO:1905667,negative regulation of protein localization to endosome;GO:0002091,negative regulation of receptor internalization	
NFKB1_HUMAN	P19838	NFKB1	Nuclear factor NF-kappa-B p105 subunit	0.53561702	0.2474586	2.421230908	4.402214845	0.39153781	3.4117228765	0.39153781	3.4117228765	0.114762489268082	0.001332	-1	8.71364856563916	0.001348	1	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0033256,I-kappaB/NF-kappaB complex;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0034774,secretory granule lumen;GO:0035580,specific granule lumen	GO:0042805,actinin binding;GO:0003682,chromatin binding;GO:0001228,DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700,DNA-binding transcription factor activity;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227,DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0019899,enzyme binding;GO:0042802,identical protein binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001225,RNA polymerase II transcription coactivator binding;GO:0000977,RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0008134,transcription factor binding;GO:0000976,transcription regulatory region sequence-specific DNA binding;GO:0003677,DNA binding	GO:0006915,apoptotic process;GO:1904385,cellular response to angiotensin;GO:0071359,cellular response to dsRNA;GO:0071347,cellular response to interleukin-1;GO:0071354,cellular response to interleukin-6;GO:0071222,cellular response to lipopolysaccharide;GO:0071260,cellular response to mechanical stimulus;GO:0071316,cellular response to nicotine;GO:0071356,cellular response to tumor necrosis factor;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0006954,inflammatory response;GO:0070498,interleukin-1-mediated signaling pathway;GO:0031293,membrane protein intracellular domain proteolysis;GO:0043066,negative regulation of apoptotic process;GO:0010956,negative regulation of calcidiol 1-monooxygenase activity;GO:0032269,negative regulation of cellular protein metabolic process;GO:0032375,negative regulation of cholesterol transport;GO:0010629,negative regulation of gene expression;GO:0050728,negative regulation of inflammatory response;GO:0032695,negative regulation of interleukin-12 production;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0010957,negative regulation of vitamin D biosynthetic process;GO:0043312,neutrophil degranulation;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:1900127,positive regulation of hyaluronan biosynthetic process;GO:0010884,positive regulation of lipid storage;GO:0010744,positive regulation of macrophage derived foam cell differentiation;GO:2000630,positive regulation of miRNA metabolic process;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0032481,positive regulation of type I interferon production;GO:0006357,regulation of transcription by RNA polymerase II;GO:0060260,regulation of transcription initiation from RNA polymerase II promoter;GO:0035994,response to muscle stretch;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0051403,stress-activated MAPK cascade;GO:0050852,T cell receptor signaling pathway;GO:0006366,transcription by RNA polymerase II	hsa:4790,path:hsa04014,Ras signaling pathway;hsa:4790,path:hsa04010,MAPK signaling pathway;hsa:4790,path:hsa04064,NF-kappa B signaling pathway;hsa:4790,path:hsa04668,TNF signaling pathway;hsa:4790,path:hsa04066,HIF-1 signaling pathway;hsa:4790,path:hsa04071,Sphingolipid signaling pathway;hsa:4790,path:hsa04024,cAMP signaling pathway;hsa:4790,path:hsa04151,PI3K-Akt signaling pathway;hsa:4790,path:hsa04210,Apoptosis;hsa:4790,path:hsa04218,Cellular senescence;hsa:4790,path:hsa04620,Toll-like receptor signaling pathway;hsa:4790,path:hsa04621,NOD-like receptor signaling pathway;hsa:4790,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:4790,path:hsa04623,Cytosolic DNA-sensing pathway;hsa:4790,path:hsa04625,C-type lectin receptor signaling pathway;hsa:4790,path:hsa04660,T cell receptor signaling pathway;hsa:4790,path:hsa04658,Th1 and Th2 cell differentiation;hsa:4790,path:hsa04659,Th17 cell differentiation;hsa:4790,path:hsa04657,IL-17 signaling pathway;hsa:4790,path:hsa04662,B cell receptor signaling pathway;hsa:4790,path:hsa04062,Chemokine signaling pathway;hsa:4790,path:hsa04920,Adipocytokine signaling pathway;hsa:4790,path:hsa04917,Prolactin signaling pathway;hsa:4790,path:hsa04926,Relaxin signaling pathway;hsa:4790,path:hsa04722,Neurotrophin signaling pathway;hsa:4790,path:hsa04380,Osteoclast differentiation;hsa:4790,path:hsa04211,Longevity regulating pathway;hsa:4790,path:hsa05200,Pathways in cancer;hsa:4790,path:hsa05202,Transcriptional misregulation in cancer;hsa:4790,path:hsa05206,MicroRNAs in cancer;hsa:4790,path:hsa05203,Viral carcinogenesis;hsa:4790,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:4790,path:hsa05212,Pancreatic cancer;hsa:4790,path:hsa05221,Acute myeloid leukemia;hsa:4790,path:hsa05220,Chronic myeloid leukemia;hsa:4790,path:hsa05215,Prostate cancer;hsa:4790,path:hsa05222,Small cell lung cancer;hsa:4790,path:hsa05321,Inflammatory bowel disease (IBD);hsa:4790,path:hsa05030,Cocaine addiction;hsa:4790,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:4790,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4790,path:hsa04931,Insulin resistance;hsa:4790,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:4790,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:4790,path:hsa05130,Pathogenic Escherichia coli infection;hsa:4790,path:hsa05132,Salmonella infection;hsa:4790,path:hsa05131,Shigellosis;hsa:4790,path:hsa05135,Yersinia infection;hsa:4790,path:hsa05133,Pertussis;hsa:4790,path:hsa05134,Legionellosis;hsa:4790,path:hsa05152,Tuberculosis;hsa:4790,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:4790,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:4790,path:hsa05162,Measles;hsa:4790,path:hsa05164,Influenza A;hsa:4790,path:hsa05161,Hepatitis B;hsa:4790,path:hsa05160,Hepatitis C;hsa:4790,path:hsa05168,Herpes simplex virus 1 infection;hsa:4790,path:hsa05163,Human cytomegalovirus infection;hsa:4790,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:4790,path:hsa05169,Epstein-Barr virus infection;hsa:4790,path:hsa05165,Human papillomavirus infection;hsa:4790,path:hsa05146,Amoebiasis;hsa:4790,path:hsa05145,Toxoplasmosis;hsa:4790,path:hsa05140,Leishmaniasis;hsa:4790,path:hsa05142,Chagas disease (American trypanosomiasis);hsa:4790,path:hsa01523,Antifolate resistance
ITA2B_HUMAN	P08514	ITGA2B	Integrin alpha-IIb	0.029117498	0.773869013	0.209912309	1.323286738	0.4014932555	0.7665995235	0.4014932555	0.7665995235	0.523732722487141	0.246962	0	1.90937086239547	0.247282	0	GO:0072562,blood microparticle;GO:0009986,cell surface;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0008305,integrin complex;GO:0005886,plasma membrane;GO:0031092,platelet alpha granule membrane;GO:0016020,membrane	GO:0050840,extracellular matrix binding;GO:0070051,fibrinogen binding;GO:0042802,identical protein binding;GO:0046872,metal ion binding	GO:0007160,cell-matrix adhesion;GO:0030198,extracellular matrix organization;GO:0007229,integrin-mediated signaling pathway;GO:0070527,platelet aggregation;GO:0002576,platelet degranulation;GO:0002687,positive regulation of leukocyte migration;GO:0045652,regulation of megakaryocyte differentiation;GO:0007155,cell adhesion	hsa:3674,path:hsa04015,Rap1 signaling pathway;hsa:3674,path:hsa04151,PI3K-Akt signaling pathway;hsa:3674,path:hsa04512,ECM-receptor interaction;hsa:3674,path:hsa04510,Focal adhesion;hsa:3674,path:hsa04810,Regulation of actin cytoskeleton;hsa:3674,path:hsa04640,Hematopoietic cell lineage;hsa:3674,path:hsa04611,Platelet activation;hsa:3674,path:hsa05200,Pathways in cancer;hsa:3674,path:hsa05222,Small cell lung cancer;hsa:3674,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:3674,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:3674,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:3674,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:3674,path:hsa05165,Human papillomavirus infection
LRP1_HUMAN	Q07954	LRP1	Prolow-density lipoprotein receptor-related protein 1	4.401385984	7.189911705	6.087426131	18.14901178	5.7956488445	12.1182189555	5.7956488445	12.1182189555	0.478259129149468	0.205287	0	2.09091669986184	0.205620	0	GO:0045177,apical part of cell;GO:0044295,axonal growth cone;GO:0016323,basolateral plasma membrane;GO:0005905,clathrin-coated pit;GO:0030136,clathrin-coated vesicle;GO:0005856,cytoskeleton;GO:0030425,dendrite;GO:0005769,early endosome;GO:0030666,endocytic vesicle membrane;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0032593,insulin-responsive compartment;GO:0005887,integral component of plasma membrane;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0043025,neuronal cell body;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0098797,plasma membrane protein complex;GO:0043235,receptor complex;GO:0016021,integral component of membrane	GO:0016964,alpha-2 macroglobulin receptor activity;GO:0001540,amyloid-beta binding;GO:0034185,apolipoprotein binding;GO:0030226,apolipoprotein receptor activity;GO:0005509,calcium ion binding;GO:0038024,cargo receptor activity;GO:0032050,clathrin heavy chain binding;GO:0015026,coreceptor activity;GO:0043395,heparan sulfate proteoglycan binding;GO:0070325,lipoprotein particle receptor binding;GO:0005041,low-density lipoprotein particle receptor activity;GO:0002020,protease binding;GO:0044877,protein-containing complex binding;GO:0003723,RNA binding;GO:0005044,scavenger receptor activity;GO:0038023,signaling receptor activity	GO:0007568,aging;GO:0097242,amyloid-beta clearance;GO:0150094,amyloid-beta clearance by cellular catabolic process;GO:0150093,amyloid-beta clearance by transcytosis;GO:0035909,aorta morphogenesis;GO:0043277,apoptotic cell clearance;GO:0002265,astrocyte activation involved in immune response;GO:0008283,cell population proliferation;GO:0044242,cellular lipid catabolic process;GO:1904646,cellular response to amyloid-beta;GO:0021987,cerebral cortex development;GO:0061642,chemoattraction of axon;GO:0006629,lipid metabolic process;GO:0042157,lipoprotein metabolic process;GO:0042953,lipoprotein transport;GO:0007041,lysosomal transport;GO:0051481,negative regulation of cytosolic calcium ion concentration;GO:0051895,negative regulation of focal adhesion assembly;GO:1905049,negative regulation of metallopeptidase activity;GO:0043524,negative regulation of neuron apoptotic process;GO:0010977,negative regulation of neuron projection development;GO:2000587,negative regulation of platelet-derived growth factor receptor-beta signaling pathway;GO:0014912,negative regulation of smooth muscle cell migration;GO:0030178,negative regulation of Wnt signaling pathway;GO:0006909,phagocytosis;GO:1900223,positive regulation of amyloid-beta clearance;GO:0048691,positive regulation of axon extension involved in regeneration;GO:0010942,positive regulation of cell death;GO:2000343,positive regulation of chemokine (C-X-C motif) ligand 2 production;GO:0010875,positive regulation of cholesterol efflux;GO:1904109,positive regulation of cholesterol import;GO:0048694,positive regulation of collateral sprouting of injured axon;GO:0007204,positive regulation of cytosolic calcium ion concentration;GO:0045807,positive regulation of endocytosis;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0032370,positive regulation of lipid transport;GO:1905167,positive regulation of lysosomal protein catabolic process;GO:0050766,positive regulation of phagocytosis;GO:0032092,positive regulation of protein binding;GO:1903078,positive regulation of protein localization to plasma membrane;GO:1900149,positive regulation of Schwann cell migration;GO:1904300,positive regulation of transcytosis;GO:1904754,positive regulation of vascular associated smooth muscle cell migration;GO:0007205,protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0031623,receptor internalization;GO:0006898,receptor-mediated endocytosis;GO:0032956,regulation of actin cytoskeleton organization;GO:0032374,regulation of cholesterol transport;GO:0010715,regulation of extracellular matrix disassembly;GO:0032429,regulation of phospholipase A2 activity;GO:0001523,retinoid metabolic process;GO:0045056,transcytosis;GO:0150104,transport across blood-brain barrier;GO:0006897,endocytosis	hsa:4035,path:hsa04979,Cholesterol metabolism;hsa:4035,path:hsa05010,Alzheimer disease;hsa:4035,path:hsa05144,Malaria
BIG1_HUMAN	Q9Y6D6	ARFGEF1	Brefeldin A-inhibited guanine nucleotide-exchange protein 1	0.25228478	0.406020818	0.433580758	0.107655383	0.329152799	0.2706180705	0.329152799	0.2706180705	1.21630014725864	0.369608	0	0.822165484608259	0.369280	0	GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016363,nuclear matrix;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm;GO:0030532,small nuclear ribonucleoprotein complex;GO:0005802,trans-Golgi network	GO:0005085,guanyl-nucleotide exchange factor activity;GO:0017022,myosin binding;GO:0034237,protein kinase A regulatory subunit binding	GO:0010256,endomembrane system organization;GO:0006887,exocytosis;GO:0007030,Golgi organization;GO:0030837,negative regulation of actin filament polymerization;GO:0034260,negative regulation of GTPase activity;GO:0031175,neuron projection development;GO:0043547,positive regulation of GTPase activity;GO:0090284,positive regulation of protein glycosylation in Golgi;GO:0051897,positive regulation of protein kinase B signaling;GO:0090303,positive regulation of wound healing;GO:0015031,protein transport;GO:0032012,regulation of ARF protein signal transduction;GO:2000114,regulation of establishment of cell polarity	hsa:10565,path:hsa04144,Endocytosis
2A5A_HUMAN	Q15172	PPP2R5A	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	0.112302819	0.101086641	0.358037762	0.500958198	0.10669473	0.42949798	0.10669473	0.42949798	0.248417303382894	0.034081	-1	4.02548448269188	0.034257	1	GO:0005813,centrosome;GO:0000775,chromosome, centromeric region;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0031430,M band;GO:0016020,membrane;GO:0005634,nucleus;GO:0000159,protein phosphatase type 2A complex;GO:0030018,Z disc	GO:0019900,kinase binding;GO:0004721,phosphoprotein phosphatase activity;GO:0072542,protein phosphatase activator activity;GO:0019888,protein phosphatase regulator activity	GO:0090219,negative regulation of lipid kinase activity;GO:1903077,negative regulation of protein localization to plasma membrane;GO:0035307,positive regulation of protein dephosphorylation;GO:0006470,protein dephosphorylation;GO:0031952,regulation of protein autophosphorylation;GO:0007165,signal transduction	hsa:5525,path:hsa03015,mRNA surveillance pathway;hsa:5525,path:hsa04071,Sphingolipid signaling pathway;hsa:5525,path:hsa04151,PI3K-Akt signaling pathway;hsa:5525,path:hsa04152,AMPK signaling pathway;hsa:5525,path:hsa04114,Oocyte meiosis;hsa:5525,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:5525,path:hsa04728,Dopaminergic synapse;hsa:5525,path:hsa05165,Human papillomavirus infection
SAC1_HUMAN	Q9NTJ5	SACM1L	Phosphatidylinositol-3-phosphatase SAC1	1.808942667	2.257738744	3.29854103	3.818557762	2.0333407055	3.558549396	2.0333407055	3.558549396	0.571395947962837	0.290827	0	1.75009991506807	0.291122	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0140268,endoplasmic reticulum-plasma membrane contact site;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0030176,integral component of endoplasmic reticulum membrane	GO:0016791,phosphatase activity;GO:0004438,phosphatidylinositol-3-phosphatase activity;GO:0043812,phosphatidylinositol-4-phosphate phosphatase activity;GO:0034593,phosphatidylinositol bisphosphate phosphatase activity	GO:0006661,phosphatidylinositol biosynthetic process;GO:0046856,phosphatidylinositol dephosphorylation	hsa:22908,path:hsa00562,Inositol phosphate metabolism;hsa:22908,path:hsa04070,Phosphatidylinositol signaling system
DHSO_HUMAN	Q00796	SORD	Sorbitol dehydrogenase	0.790110733	0.447971892	1.07289065	0.647883677	0.6190413125	0.8603871635	0.6190413125	0.8603871635	0.719491571656857	0.421220	0	1.38987034649646	0.421398	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0016020,membrane;GO:0031966,mitochondrial membrane;GO:0031514,motile cilium	GO:0000721,(R,R)-butanediol dehydrogenase activity;GO:0030246,carbohydrate binding;GO:0046526,D-xylulose reductase activity;GO:0042802,identical protein binding;GO:0003939,L-iditol 2-dehydrogenase activity;GO:0051287,NAD binding;GO:0050255,ribitol 2-dehydrogenase activity;GO:0008270,zinc ion binding;GO:0016491,oxidoreductase activity	GO:0030317,flagellated sperm motility;GO:0046370,fructose biosynthetic process;GO:0006006,glucose metabolic process;GO:0019640,glucuronate catabolic process to xylulose 5-phosphate;GO:0051160,L-xylitol catabolic process;GO:0051164,L-xylitol metabolic process;GO:0046686,response to cadmium ion;GO:0046688,response to copper ion;GO:0042493,response to drug;GO:0009725,response to hormone;GO:0031667,response to nutrient levels;GO:0006970,response to osmotic stress;GO:0006062,sorbitol catabolic process	hsa:6652,path:hsa00040,Pentose and glucuronate interconversions;hsa:6652,path:hsa00051,Fructose and mannose metabolism
TSPO_HUMAN	P30536	TSPO	Translocator protein	2.112005538	12.50923564	0.401457233	0.83221353	7.310620589	0.6168353815	7.310620589	0.6168353815	11.8518178565281	0.012167	1	0.0843752420181848	0.012005	-1	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0031966,mitochondrial membrane	GO:0005497,androgen binding;GO:0008503,benzodiazepine receptor activity;GO:0015485,cholesterol binding;GO:0044325,ion channel binding	GO:0030325,adrenal gland development;GO:0007568,aging;GO:0006820,anion transport;GO:0048266,behavioral response to pain;GO:0006700,C21-steroid hormone biosynthetic process;GO:0071476,cellular hypotonic response;GO:0071222,cellular response to lipopolysaccharide;GO:0071294,cellular response to zinc ion;GO:0006821,chloride transport;GO:0060242,contact inhibition;GO:0008347,glial cell migration;GO:0006783,heme biosynthetic process;GO:0006869,lipid transport;GO:0072656,maintenance of protein location in mitochondrion;GO:1903579,negative regulation of ATP metabolic process;GO:1903147,negative regulation of autophagy of mitochondrion;GO:0060253,negative regulation of glial cell proliferation;GO:0045019,negative regulation of nitric oxide biosynthetic process;GO:0031397,negative regulation of protein ubiquitination;GO:0032720,negative regulation of tumor necrosis factor production;GO:0014012,peripheral nervous system axon regeneration;GO:0043065,positive regulation of apoptotic process;GO:0051928,positive regulation of calcium ion transport;GO:0060252,positive regulation of glial cell proliferation;GO:0051901,positive regulation of mitochondrial depolarization;GO:0010940,positive regulation of necrotic cell death;GO:2000379,positive regulation of reactive oxygen species metabolic process;GO:0006626,protein targeting to mitochondrion;GO:0042127,regulation of cell population proliferation;GO:0032374,regulation of cholesterol transport;GO:0050810,regulation of steroid biosynthetic process;GO:0042493,response to drug;GO:0010042,response to manganese ion;GO:0032570,response to progesterone;GO:0033574,response to testosterone;GO:0010266,response to vitamin B1;GO:0008202,steroid metabolic process;GO:0072655,establishment of protein localization to mitochondrion;GO:0006694,steroid biosynthetic process	hsa:706,path:hsa04080,Neuroactive ligand-receptor interaction;hsa:706,path:hsa04979,Cholesterol metabolism;hsa:706,path:hsa05166,Human T-cell leukemia virus 1 infection
RS4X_HUMAN	P62701	RPS4X	40S ribosomal protein S4, X isoform	15.26767489	63.08370777	7.56338434	8.118928613	39.17569133	7.8411564765	39.17569133	7.8411564765	4.99616242162872	0.063787	0	0.200153621041408	0.063348	0	GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005844,polysome;GO:1990904,ribonucleoprotein complex;GO:0005840,ribosome;GO:0015935,small ribosomal subunit;GO:0045202,synapse	GO:0003723,RNA binding;GO:0019843,rRNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0007275,multicellular organism development;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0008284,positive regulation of cell population proliferation;GO:0045727,positive regulation of translation;GO:0045471,response to ethanol;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6191,path:hsa03010,Ribosome
NHP2_HUMAN	Q9NX24	NHP2	H/ACA ribonucleoprotein complex subunit 2	0.51189254	0.439718823	0.044090164	2.55E-05	0.4758056815	0.022057832	0.4758056815	0.022057832	21.5708271556334	0.002921	1	0.0463589083897898	0.002865	-1	GO:0072589,box H/ACA scaRNP complex;GO:0031429,box H/ACA snoRNP complex;GO:0090661,box H/ACA telomerase RNP complex;GO:0000781,chromosome, telomeric region;GO:0005654,nucleoplasm;GO:0005732,sno(s)RNA-containing ribonucleoprotein complex;GO:0005697,telomerase holoenzyme complex;GO:0005730,nucleolus	GO:0034513,box H/ACA snoRNA binding;GO:0003723,RNA binding;GO:0070034,telomerase RNA binding	GO:0000469,cleavage involved in rRNA processing;GO:0000470,maturation of LSU-rRNA;GO:1904874,positive regulation of telomerase RNA localization to Cajal body;GO:0031118,rRNA pseudouridine synthesis;GO:0031120,snRNA pseudouridine synthesis;GO:0007004,telomere maintenance via telomerase	hsa:55651,path:hsa03008,Ribosome biogenesis in eukaryotes
VTDB_HUMAN	P02774	GC	Vitamin D-binding protein	4.602190432	4.352575949	6.855290438	26.50254995	4.4773831905	16.678920194	4.4773831905	16.678920194	0.268445627080264	0.044056	-1	3.72514915171632	0.044261	1	GO:0072562,blood microparticle;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043202,lysosomal lumen	GO:0003779,actin binding;GO:1902118,calcidiol binding;GO:0005499,vitamin D binding;GO:0090482,vitamin transmembrane transporter activity	GO:0042359,vitamin D metabolic process;GO:0051180,vitamin transport	
CMC2_HUMAN	Q9UJS0	SLC25A13	Calcium-binding mitochondrial carrier protein Aralar2	0.722910098	1.402058844	1.242160493	0.747910938	1.062484471	0.9950357155	1.062484471	0.9950357155	1.06778526081962	0.411717	0	0.936517890528303	0.411475	0	GO:0005887,integral component of plasma membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion	GO:0005509,calcium ion binding;GO:0042802,identical protein binding;GO:0015183,L-aspartate transmembrane transporter activity;GO:0005313,L-glutamate transmembrane transporter activity;GO:0022857,transmembrane transporter activity;GO:0015171,amino acid transmembrane transporter activity	GO:0009066,aspartate family amino acid metabolic process;GO:0015810,aspartate transmembrane transport;GO:0006754,ATP biosynthetic process;GO:0045333,cellular respiration;GO:0006094,gluconeogenesis;GO:0015813,L-glutamate transmembrane transport;GO:0043490,malate-aspartate shuttle;GO:0006839,mitochondrial transport;GO:0051592,response to calcium ion	
SYNE2_HUMAN	Q8WXH0	SYNE2	Nesprin-2	0.220768189	0.338078367	0.592326638	0.23389948	0.279423278	0.413113059	0.279423278	0.413113059	0.676384519715703	0.384688	0	1.47844897517808	0.384903	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0031527,filopodium membrane;GO:0005925,focal adhesion;GO:0016021,integral component of membrane;GO:0045111,intermediate filament cytoskeleton;GO:0031258,lamellipodium membrane;GO:0034993,meiotic nuclear membrane microtubule tethering complex;GO:0005739,mitochondrion;GO:0005635,nuclear envelope;GO:0031981,nuclear lumen;GO:0031965,nuclear membrane;GO:0005640,nuclear outer membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016529,sarcoplasmic reticulum;GO:0033017,sarcoplasmic reticulum membrane;GO:0030018,Z disc	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0140444,cytoskeleton-nuclear membrane anchor activity	GO:0051642,centrosome localization;GO:0007097,nuclear migration;GO:0031022,nuclear migration along microfilament;GO:0021817,nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration;GO:0030335,positive regulation of cell migration;GO:1902017,regulation of cilium assembly	
GPAA1_HUMAN	O43292	GPAA1	Glycosylphosphatidylinositol anchor attachment 1 protein	0.215766464	0.477634358	0.284631084	0.205105944	0.346700411	0.244868514	0.346700411	0.244868514	1.41586358056634	0.322419	0	0.706282733538496	0.322005	0	GO:0005813,centrosome;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0042765,GPI-anchor transamidase complex;GO:0016020,membrane;GO:0005739,mitochondrion	GO:0015631,tubulin binding	GO:0016255,attachment of GPI anchor to protein;GO:0006621,protein retention in ER lumen;GO:0065003,protein-containing complex assembly;GO:0006508,proteolysis	hsa:8733,path:hsa00563,Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
PLOD1_HUMAN	Q02809	PLOD1	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	3.356456583	2.704760339	2.063495199	7.527921275	3.030608461	4.795708237	3.030608461	4.795708237	0.631941792792596	0.345663	0	1.58242422230207	0.345915	0	GO:1902494,catalytic complex;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0030867,rough endoplasmic reticulum membrane	GO:0005506,iron ion binding;GO:0031418,L-ascorbic acid binding;GO:0008475,procollagen-lysine 5-dioxygenase activity	GO:0030199,collagen fibril organization;GO:0008544,epidermis development;GO:0017185,peptidyl-lysine hydroxylation;GO:0001666,response to hypoxia	hsa:5351,path:hsa00310,Lysine degradation
RB12B_HUMAN	Q8IXT5	RBM12B	RNA-binding protein 12B	0.093399222	0.042222746	0.145967897	2.55E-05	0.067810984	0.0729966985	0.067810984	0.0729966985	0.928959602193516	0.457895	0	1.07647307551237	0.457752	0	GO:0005654,nucleoplasm;GO:1990904,ribonucleoprotein complex	GO:0003723,RNA binding;GO:0003676,nucleic acid binding	GO:0043484,regulation of RNA splicing	
KNG1_HUMAN	P01042	KNG1	Kininogen-1	2.403657292	1.680651882	3.850997108	16.43547764	2.042154587	10.143237374	2.042154587	10.143237374	0.201331637198457	0.015973	-1	4.96692926116861	0.016080	1	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane;GO:0031093,platelet alpha granule lumen	GO:0004869,cysteine-type endopeptidase inhibitor activity;GO:0004866,endopeptidase inhibitor activity;GO:0008201,heparin binding;GO:0005102,signaling receptor binding;GO:0008270,zinc ion binding	GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0007597,blood coagulation, intrinsic pathway;GO:0044267,cellular protein metabolic process;GO:0007186,G protein-coupled receptor signaling pathway;GO:0006954,inflammatory response;GO:0031640,killing of cells of other organism;GO:0030195,negative regulation of blood coagulation;GO:0007162,negative regulation of cell adhesion;GO:0010951,negative regulation of endopeptidase activity;GO:0045861,negative regulation of proteolysis;GO:0002576,platelet degranulation;GO:0043065,positive regulation of apoptotic process;GO:0007204,positive regulation of cytosolic calcium ion concentration;GO:0043687,post-translational protein modification;GO:0042311,vasodilation	hsa:3827,path:hsa04071,Sphingolipid signaling pathway;hsa:3827,path:hsa04022,cGMP-PKG signaling pathway;hsa:3827,path:hsa04080,Neuroactive ligand-receptor interaction;hsa:3827,path:hsa04810,Regulation of actin cytoskeleton;hsa:3827,path:hsa04610,Complement and coagulation cascades;hsa:3827,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:3827,path:hsa05200,Pathways in cancer;hsa:3827,path:hsa05142,Chagas disease (American trypanosomiasis);hsa:3827,path:hsa05143,African trypanosomiasis
ZYX_HUMAN	Q15942	ZYX	Zyxin	3.770137979	4.123071538	1.696605565	4.549484602	3.9466047585	3.1230450835	3.9466047585	3.1230450835	1.26370406221515	0.357512	0	0.791324511727135	0.357160	0	GO:0015629,actin cytoskeleton;GO:0005912,adherens junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005634,nucleus;GO:0045335,phagocytic vesicle;GO:0005886,plasma membrane;GO:0001725,stress fiber	GO:0046872,metal ion binding;GO:0003723,RNA binding	GO:0007267,cell-cell signaling;GO:0007160,cell-matrix adhesion;GO:0071346,cellular response to interferon-gamma;GO:0007229,integrin-mediated signaling pathway;GO:0050727,regulation of inflammatory response;GO:0007165,signal transduction;GO:0043149,stress fiber assembly;GO:0007179,transforming growth factor beta receptor signaling pathway;GO:0016032,viral process	hsa:7791,path:hsa04510,Focal adhesion
BCLF1_HUMAN	Q9NYF8	BCLAF1	Bcl-2-associated transcription factor 1	0.894217086	0.417287309	0.452607931	0.16413482	0.6557521975	0.3083713755	0.6557521975	0.3083713755	2.12650151602674	0.210765	0	0.470255954422478	0.210211	0	GO:0005737,cytoplasm;GO:0016592,mediator complex;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0003723,RNA binding;GO:0003712,transcription coregulator activity	GO:0006915,apoptotic process;GO:1990830,cellular response to leukemia inhibitory factor;GO:0045892,negative regulation of transcription, DNA-templated;GO:0043065,positive regulation of apoptotic process;GO:2000144,positive regulation of DNA-templated transcription, initiation;GO:2001244,positive regulation of intrinsic apoptotic signaling pathway;GO:2001022,positive regulation of response to DNA damage stimulus;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0043620,regulation of DNA-templated transcription in response to stress;GO:0006397,mRNA processing;GO:0051028,mRNA transport;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006417,regulation of translation;GO:0008380,RNA splicing	
ATX2L_HUMAN	Q8WWM7	ATXN2L	Ataxin-2-like protein	0.078987222	0.03112694	0.082479757	0.00362132	0.055057081	0.0430505385	0.055057081	0.0430505385	1.2788941304416	0.353760	0	0.781925552863945	0.353402	0	GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0016021,integral component of membrane	GO:0045296,cadherin binding;GO:0003723,RNA binding	GO:0010603,regulation of cytoplasmic mRNA processing body assembly;GO:0034063,stress granule assembly	hsa:11273,path:hsa05017,Spinocerebellar ataxia
RL5_HUMAN	P46777	RPL5	60S ribosomal protein L5	3.78582808	2.187317345	1.305097619	0.926626653	2.9865727125	1.115862136	2.9865727125	1.115862136	2.67647105869717	0.159225	0	0.373626307951476	0.158655	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:1990904,ribonucleoprotein complex;GO:0005840,ribosome	GO:0008097,5S rRNA binding;GO:0003730,mRNA 3'-UTR binding;GO:0048027,mRNA 5'-UTR binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome;GO:1990948,ubiquitin ligase inhibitor activity;GO:0031625,ubiquitin protein ligase binding	GO:0002181,cytoplasmic translation;GO:2000435,negative regulation of protein neddylation;GO:1904667,negative regulation of ubiquitin protein ligase activity;GO:2000059,negative regulation of ubiquitin-dependent protein catabolic process;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0010628,positive regulation of gene expression;GO:0045727,positive regulation of translation;GO:0050821,protein stabilization;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0000027,ribosomal large subunit assembly;GO:0042273,ribosomal large subunit biogenesis;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6125,path:hsa03010,Ribosome
DERL1_HUMAN	Q9BUN8	DERL1	Derlin-1	0.56400542	1.421939171	0.125070393	0.050382442	0.9929722955	0.0877264175	0.9929722955	0.0877264175	11.3189655271173	0.013447	1	0.0883472961910044	0.013274	-1	GO:0036513,Derlin-1 retrotranslocation complex;GO:0036502,Derlin-1-VIMP complex;GO:0005769,early endosome;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0044322,endoplasmic reticulum quality control compartment;GO:0000839,Hrd1p ubiquitin ligase ERAD-L complex;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0005770,late endosome;GO:0016020,membrane	GO:0051117,ATPase binding;GO:0042802,identical protein binding;GO:0042288,MHC class I protein binding;GO:0051787,misfolded protein binding;GO:0002020,protease binding;GO:0044877,protein-containing complex binding;GO:0005047,signal recognition particle binding;GO:0038023,signaling receptor activity;GO:0031625,ubiquitin protein ligase binding;GO:1990381,ubiquitin-specific protease binding	GO:0030968,endoplasmic reticulum unfolded protein response;GO:0071712,ER-associated misfolded protein catabolic process;GO:0036503,ERAD pathway;GO:0045184,establishment of protein localization;GO:0032092,positive regulation of protein binding;GO:0031398,positive regulation of protein ubiquitination;GO:0031648,protein destabilization;GO:0006457,protein folding;GO:0016567,protein ubiquitination;GO:0006986,response to unfolded protein;GO:0030970,retrograde protein transport, ER to cytosol;GO:0055085,transmembrane transport;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0016032,viral process	hsa:79139,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:79139,path:hsa05014,Amyotrophic lateral sclerosis (ALS)
MATN2_HUMAN	O00339	MATN2	Matrilin-2	0.013596316	0.01259793	0.068506558	0.446260474	0.013097123	0.257383516	0.013097123	0.257383516	0.0508856324738372	0.000011	-1	19.6519125612549	0.000011	1	GO:0062023,collagen-containing extracellular matrix;GO:0031012,extracellular matrix;GO:0005576,extracellular region	GO:0005509,calcium ion binding;GO:0005201,extracellular matrix structural constituent		
TPIS_HUMAN	P60174	TPI1	Triosephosphate isomerase	57.97844524	63.90691089	48.51669747	36.78487616	60.942678065	42.650786815	60.942678065	42.650786815	1.42887582190083	0.319658	0	0.699850879042593	0.319239	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005634,nucleus	GO:0008929,methylglyoxal synthase activity;GO:0042803,protein homodimerization activity;GO:0004807,triose-phosphate isomerase activity;GO:0031625,ubiquitin protein ligase binding	GO:0061621,canonical glycolysis;GO:0006094,gluconeogenesis;GO:0046166,glyceraldehyde-3-phosphate biosynthetic process;GO:0019563,glycerol catabolic process;GO:0006096,glycolytic process;GO:0019242,methylglyoxal biosynthetic process;GO:0007275,multicellular organism development	hsa:7167,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:7167,path:hsa00051,Fructose and mannose metabolism;hsa:7167,path:hsa00562,Inositol phosphate metabolism
BAIP2_HUMAN	Q9UQB8	BAIAP2	Brain-specific angiogenesis inhibitor 1-associated protein 2	0.108069299	0.01210227	0.07940223	2.55E-05	0.0600857845	0.039713865	0.0600857845	0.039713865	1.51296743593201	0.302629	0	0.660952758301758	0.302182	0	GO:0005912,adherens junction;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0030175,filopodium;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0001726,ruffle;GO:0016020,membrane;GO:0043198,dendritic shaft;GO:0061846,dendritic spine cytoplasm;GO:0060076,excitatory synapse;GO:0098978,glutamatergic synapse;GO:0005794,Golgi apparatus;GO:0030027,lamellipodium;GO:0005874,microtubule;GO:0061845,neuron projection branch point;GO:0044306,neuron projection terminus;GO:0043025,neuronal cell body;GO:0099524,postsynaptic cytosol;GO:0099092,postsynaptic density, intracellular component;GO:0099523,presynaptic cytosol;GO:0005791,rough endoplasmic reticulum;GO:0098685,Schaffer collateral - CA1 synapse;GO:0030141,secretory granule;GO:0097060,synaptic membrane	GO:0098641,cadherin binding involved in cell-cell adhesion;GO:0008093,cytoskeletal anchor activity;GO:0042802,identical protein binding;GO:0070064,proline-rich region binding;GO:0008022,protein C-terminus binding;GO:0030165,PDZ domain binding;GO:0097110,scaffold protein binding;GO:0001221,transcription coregulator binding	GO:0051764,actin crosslink formation;GO:0051017,actin filament bundle assembly;GO:0007409,axonogenesis;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0008286,insulin receptor signaling pathway;GO:0007009,plasma membrane organization;GO:2000251,positive regulation of actin cytoskeleton reorganization;GO:0030838,positive regulation of actin filament polymerization;GO:0032956,regulation of actin cytoskeleton organization;GO:0008360,regulation of cell shape;GO:0009617,response to bacterium;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:0007420,brain development;GO:0071364,cellular response to epidermal growth factor stimulus;GO:1905232,cellular response to L-glutamate;GO:0016358,dendrite development;GO:0099564,modification of synaptic structure, modulating synaptic transmission;GO:0061003,positive regulation of dendritic spine morphogenesis;GO:2000463,positive regulation of excitatory postsynaptic potential;GO:0035418,protein localization to synapse;GO:1905274,regulation of modification of postsynaptic actin cytoskeleton;GO:0048167,regulation of synaptic plasticity	hsa:10458,path:hsa04520,Adherens junction;hsa:10458,path:hsa04810,Regulation of actin cytoskeleton;hsa:10458,path:hsa05130,Pathogenic Escherichia coli infection;hsa:10458,path:hsa05135,Yersinia infection
FIBG_HUMAN	P02679	FGG	Fibrinogen gamma chain	20.69590032	89.41603508	137.9868039	269.5680523	55.0559677	203.7774281	55.0559677	203.7774281	0.270176968142822	0.044980	-1	3.70127774722594	0.045186	1	GO:0072562,blood microparticle;GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005577,fibrinogen complex;GO:0005886,plasma membrane;GO:0031091,platelet alpha granule;GO:0031093,platelet alpha granule lumen;GO:0005737,cytoplasm	GO:0050839,cell adhesion molecule binding;GO:0005201,extracellular matrix structural constituent;GO:0046872,metal ion binding;GO:0005102,signaling receptor binding;GO:0005198,structural molecule activity;GO:0042802,identical protein binding	GO:0007596,blood coagulation;GO:0072378,blood coagulation, fibrin clot formation;GO:0007160,cell-matrix adhesion;GO:0044267,cellular protein metabolic process;GO:0034622,cellular protein-containing complex assembly;GO:0030198,extracellular matrix organization;GO:0042730,fibrinolysis;GO:2000352,negative regulation of endothelial cell apoptotic process;GO:1902042,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0031639,plasminogen activation;GO:0070527,platelet aggregation;GO:0002576,platelet degranulation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0045921,positive regulation of exocytosis;GO:0034116,positive regulation of heterotypic cell-cell adhesion;GO:0090277,positive regulation of peptide hormone secretion;GO:0050714,positive regulation of protein secretion;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0045907,positive regulation of vasoconstriction;GO:0043687,post-translational protein modification;GO:0051258,protein polymerization;GO:0009306,protein secretion;GO:0051592,response to calcium ion;GO:0002224,toll-like receptor signaling pathway;GO:0030168,platelet activation;GO:0071347,cellular response to interleukin-1;GO:0071354,cellular response to interleukin-6;GO:0090331,negative regulation of platelet aggregation;GO:0036345,platelet maturation	hsa:2266,path:hsa04610,Complement and coagulation cascades;hsa:2266,path:hsa04611,Platelet activation;hsa:2266,path:hsa05150,Staphylococcus aureus infection
SMHD1_HUMAN	A6NHR9	SMCHD1	Structural maintenance of chromosomes flexible hinge domain-containing protein 1	0.358080807	0.125235688	0.569963588	0.370450752	0.2416582475	0.47020717	0.2416582475	0.47020717	0.513939945875347	0.237946	0	1.94575262737515	0.238270	0	GO:0001740,Barr body;GO:0035861,site of double-strand break;GO:0005694,chromosome	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0003677,DNA binding;GO:0042803,protein homodimerization activity	GO:0009048,dosage compensation by inactivation of X chromosome;GO:0006302,double-strand break repair;GO:0070868,heterochromatin organization involved in chromatin silencing;GO:0060821,inactivation of X chromosome by DNA methylation;GO:0060820,inactivation of X chromosome by heterochromatin assembly;GO:2000042,negative regulation of double-strand break repair via homologous recombination;GO:0043584,nose development;GO:0045739,positive regulation of DNA repair;GO:2001034,positive regulation of double-strand break repair via nonhomologous end joining;GO:0051276,chromosome organization	
PRKRA_HUMAN	O75569	PRKRA	Interferon-inducible double-stranded RNA-dependent protein kinase activator A	0.425404889	0.399798407	0.345302784	2.55E-05	0.412601648	0.172664142	0.412601648	0.172664142	2.38961977409299	0.183503	0	0.418476617427374	0.182935	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm;GO:0070578,RISC-loading complex	GO:0003725,double-stranded RNA binding;GO:0008047,enzyme activator activity;GO:0019899,enzyme binding;GO:0042802,identical protein binding;GO:0070883,pre-miRNA binding;GO:0042803,protein homodimerization activity;GO:0003723,RNA binding;GO:0016301,kinase activity	GO:0034599,cellular response to oxidative stress;GO:0006955,immune response;GO:0042474,middle ear morphogenesis;GO:0010586,miRNA metabolic process;GO:0008285,negative regulation of cell population proliferation;GO:0042473,outer ear morphogenesis;GO:2001244,positive regulation of intrinsic apoptotic signaling pathway;GO:0031054,pre-miRNA processing;GO:0035196,production of miRNAs involved in gene silencing by miRNA;GO:0030422,production of siRNA involved in RNA interference;GO:0006468,protein phosphorylation;GO:0050821,protein stabilization;GO:0009615,response to virus;GO:0048705,skeletal system morphogenesis;GO:0016032,viral process	
MIME_HUMAN	P20774	OGN	Mimecan	0.826824371	6.79857669	3.47231059	63.40920488	3.8127005305	33.440757735	3.8127005305	33.440757735	0.114013580694361	0.001289	-1	8.77088495870263	0.001304	1	GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1903561,extracellular vesicle;GO:0005796,Golgi lumen;GO:0043202,lysosomal lumen	GO:0008083,growth factor activity	GO:0018146,keratan sulfate biosynthetic process;GO:0042340,keratan sulfate catabolic process;GO:0048662,negative regulation of smooth muscle cell proliferation	
HCD2_HUMAN	Q99714	HSD17B10	3-hydroxyacyl-CoA dehydrogenase type-2	5.498135122	5.913421841	6.400556704	3.03475818	5.7057784815	4.717657442	5.7057784815	4.717657442	1.20945162968024	0.371405	0	0.826820995118578	0.371081	0	GO:0005737,cytoplasm;GO:0005759,mitochondrial matrix;GO:0042645,mitochondrial nucleoid;GO:0030678,mitochondrial ribonuclease P complex;GO:0005739,mitochondrion;GO:0005886,plasma membrane	GO:0044594,17-beta-hydroxysteroid dehydrogenase (NAD+) activity;GO:0047015,3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity;GO:0003857,3-hydroxyacyl-CoA dehydrogenase activity;GO:0047044,androstan-3-alpha,17-beta-diol dehydrogenase activity;GO:0106281,chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity;GO:0008709,cholate 7-alpha-dehydrogenase activity;GO:0106282,isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity;GO:0003723,RNA binding;GO:0047035,testosterone dehydrogenase (NAD+) activity;GO:0030283,testosterone dehydrogenase [NAD(P)] activity;GO:0000049,tRNA binding;GO:0106283,ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity;GO:0016491,oxidoreductase activity	GO:0008209,androgen metabolic process;GO:0006699,bile acid biosynthetic process;GO:0009083,branched-chain amino acid catabolic process;GO:0062173,brexanolone metabolic process;GO:0008207,C21-steroid hormone metabolic process;GO:0008210,estrogen metabolic process;GO:0006635,fatty acid beta-oxidation;GO:0006550,isoleucine catabolic process;GO:0006629,lipid metabolic process;GO:1990180,mitochondrial tRNA 3'-end processing;GO:0097745,mitochondrial tRNA 5'-end processing;GO:0070901,mitochondrial tRNA methylation;GO:0007005,mitochondrion organization;GO:0051289,protein homotetramerization	hsa:3028,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:3028,path:hsa05010,Alzheimer disease
YIF1A_HUMAN	O95070	YIF1A	Protein YIF1A	0.105522194	0.411540698	0.022869803	0.020908924	0.258531446	0.0218893635	0.258531446	0.0218893635	11.810825198275	0.012260	1	0.0846680890803512	0.012097	-1	GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005794,Golgi apparatus;GO:0030173,integral component of Golgi membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016021,integral component of membrane		GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0036498,IRE1-mediated unfolded protein response;GO:0015031,protein transport	
ANAG_HUMAN	P54802	NAGLU	Alpha-N-acetylglucosaminidase	1.063416961	0.758443314	0.991341746	14.44727112	0.9109301375	7.719306433	0.9109301375	7.719306433	0.11800673355909	0.001531	-1	8.47409270505116	0.001549	1	GO:0070062,extracellular exosome;GO:0043202,lysosomal lumen;GO:0005764,lysosome	GO:0004561,alpha-N-acetylglucosaminidase activity	GO:0021680,cerebellar Purkinje cell layer development;GO:0006027,glycosaminoglycan catabolic process;GO:0060119,inner ear receptor cell development;GO:0045475,locomotor rhythm;GO:0007040,lysosome organization;GO:0042474,middle ear morphogenesis;GO:0007399,nervous system development;GO:0046548,retinal rod cell development	hsa:4669,path:hsa00531,Glycosaminoglycan degradation;hsa:4669,path:hsa04142,Lysosome
DNJA1_HUMAN	P31689	DNAJA1	DnaJ homolog subfamily A member 1	1.141224145	0.449813988	0.972342601	0.765546029	0.7955190665	0.868944315	0.7955190665	0.868944315	0.915500628483886	0.462778	0	1.0922985401507	0.462645	0	GO:0098554,cytoplasmic side of endoplasmic reticulum membrane;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0015630,microtubule cytoskeleton;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm	GO:0005524,ATP binding;GO:0001671,ATPase activator activity;GO:0055131,C3HC4-type RING finger domain binding;GO:0051087,chaperone binding;GO:0001664,G protein-coupled receptor binding;GO:0030544,Hsp70 protein binding;GO:0050750,low-density lipoprotein particle receptor binding;GO:0046872,metal ion binding;GO:0030957,Tat protein binding;GO:0031625,ubiquitin protein ligase binding;GO:0051082,unfolded protein binding	GO:0030521,androgen receptor signaling pathway;GO:0042769,DNA damage response, detection of DNA damage;GO:0030317,flagellated sperm motility;GO:0043066,negative regulation of apoptotic process;GO:1903748,negative regulation of establishment of protein localization to mitochondrion;GO:0043508,negative regulation of JUN kinase activity;GO:1905259,negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway;GO:0031397,negative regulation of protein ubiquitination;GO:0043065,positive regulation of apoptotic process;GO:0006457,protein folding;GO:0070585,protein localization to mitochondrion;GO:0051223,regulation of protein transport;GO:0009408,response to heat;GO:0006986,response to unfolded protein;GO:0007283,spermatogenesis;GO:1901998,toxin transport	hsa:3301,path:hsa04141,Protein processing in endoplasmic reticulum
RASA1_HUMAN	P20936	RASA1	Ras GTPase-activating protein 1	0.041614669	0.167869237	0.234546947	0.154174592	0.104741953	0.1943607695	0.104741953	0.1943607695	0.53890480712467	0.260944	0	1.85561529008343	0.261257	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005886,plasma membrane;GO:0001726,ruffle	GO:0005096,GTPase activator activity;GO:0051020,GTPase binding;GO:0001784,phosphotyrosine residue binding;GO:0019870,potassium channel inhibitor activity;GO:0005102,signaling receptor binding	GO:0048514,blood vessel morphogenesis;GO:0048013,ephrin receptor signaling pathway;GO:0035556,intracellular signal transduction;GO:0000165,MAPK cascade;GO:0000281,mitotic cytokinesis;GO:0043066,negative regulation of apoptotic process;GO:0007162,negative regulation of cell adhesion;GO:0001953,negative regulation of cell-matrix adhesion;GO:0043524,negative regulation of neuron apoptotic process;GO:0046580,negative regulation of Ras protein signal transduction;GO:0030833,regulation of actin filament polymerization;GO:0008360,regulation of cell shape;GO:0051252,regulation of RNA metabolic process;GO:0007165,signal transduction;GO:0001570,vasculogenesis;GO:0043547,positive regulation of GTPase activity	hsa:5921,path:hsa04014,Ras signaling pathway;hsa:5921,path:hsa04010,MAPK signaling pathway;hsa:5921,path:hsa04360,Axon guidance
BROX_HUMAN	Q5VW32	BROX	BRO1 domain-containing protein BROX	0.503248846	0.487798475	0.50887796	0.508050442	0.4955236605	0.508464201	0.4955236605	0.508464201	0.974549751045305	0.441913	0	1.02611487912997	0.441735	0	GO:0070062,extracellular exosome;GO:0016020,membrane			
MUTA_HUMAN	P22033	MMUT	Methylmalonyl-CoA mutase, mitochondrial	0.671158459	0.47462252	1.07170786	0.540718824	0.5728904895	0.806213342	0.5728904895	0.806213342	0.710594156230176	0.413796	0	1.40727304218933	0.413982	0	GO:0005737,cytoplasm;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0031419,cobalamin binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0004494,methylmalonyl-CoA mutase activity;GO:0072341,modified amino acid binding;GO:0042803,protein homodimerization activity	GO:0009235,cobalamin metabolic process;GO:0050667,homocysteine metabolic process;GO:0043547,positive regulation of GTPase activity;GO:0009791,post-embryonic development;GO:0019626,short-chain fatty acid catabolic process	hsa:4594,path:hsa00630,Glyoxylate and dicarboxylate metabolism;hsa:4594,path:hsa00640,Propanoate metabolism;hsa:4594,path:hsa00280,Valine, leucine and isoleucine degradation
MYH9_HUMAN	P35579	MYH9	Myosin-9	242.2145969	218.0245821	200.9233024	326.0500546	230.1195895	263.4866785	230.1195895	263.4866785	0.873363278971237	0.478578	0	1.14499890718778	0.478481	0	GO:0015629,actin cytoskeleton;GO:0042641,actomyosin;GO:0005826,actomyosin contractile ring;GO:0005912,adherens junction;GO:0005903,brush border;GO:0031252,cell leading edge;GO:0032154,cleavage furrow;GO:0060473,cortical granule;GO:0005737,cytoplasm;GO:0009898,cytoplasmic side of plasma membrane;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0001772,immunological synapse;GO:0016020,membrane;GO:0016460,myosin II complex;GO:0097513,myosin II filament;GO:0031594,neuromuscular junction;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0001726,ruffle;GO:0005819,spindle;GO:0001725,stress fiber;GO:0001931,uropod;GO:0016459,myosin complex	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0030898,actin-dependent ATPase activity;GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0045296,cadherin binding;GO:0005516,calmodulin binding;GO:0042802,identical protein binding;GO:0005178,integrin binding;GO:0000146,microfilament motor activity;GO:0003774,motor activity;GO:0019904,protein domain specific binding;GO:0042803,protein homodimerization activity;GO:0043495,protein-membrane adaptor activity;GO:0003723,RNA binding	GO:0031532,actin cytoskeleton reorganization;GO:0030048,actin filament-based movement;GO:0031032,actomyosin structure organization;GO:0001525,angiogenesis;GO:0043534,blood vessel endothelial cell migration;GO:0060471,cortical granule exocytosis;GO:0032506,cytokinetic process;GO:0051295,establishment of meiotic spindle localization;GO:0001768,establishment of T cell polarity;GO:0001701,in utero embryonic development;GO:0007229,integrin-mediated signaling pathway;GO:0050900,leukocyte migration;GO:0032418,lysosome localization;GO:0000212,meiotic spindle organization;GO:0006509,membrane protein ectodomain proteolysis;GO:0030224,monocyte differentiation;GO:0007520,myoblast fusion;GO:1903919,negative regulation of actin filament severing;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0006911,phagocytosis, engulfment;GO:0001778,plasma membrane repair;GO:0070527,platelet aggregation;GO:0030220,platelet formation;GO:1903923,positive regulation of protein processing in phagocytic vesicle;GO:0015031,protein transport;GO:0045055,regulated exocytosis;GO:0008360,regulation of cell shape;GO:1905684,regulation of plasma membrane repair;GO:0032796,uropod organization	hsa:4627,path:hsa04530,Tight junction;hsa:4627,path:hsa04810,Regulation of actin cytoskeleton;hsa:4627,path:hsa05130,Pathogenic Escherichia coli infection;hsa:4627,path:hsa05132,Salmonella infection
RRP12_HUMAN	Q5JTH9	RRP12	RRP12-like protein	0.165348661	0.139937287	0.191776047	0.033205365	0.152642974	0.112490706	0.152642974	0.112490706	1.35693853677121	0.335376	0	0.736953054910998	0.334984	0	GO:0005829,cytosol;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0031965,nuclear membrane;GO:0005730,nucleolus;GO:0005886,plasma membrane	GO:0003723,RNA binding	GO:0006364,rRNA processing	
MK09_HUMAN	P45984	MAPK9	Mitogen-activated protein kinase 9	0.023855529	0.054425657	0.129962744	0.030649552	0.039140593	0.080306148	0.039140593	0.080306148	0.487392235523487	0.213604	0	2.05173559838503	0.213936	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0004705,JUN kinase activity;GO:0004707,MAP kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0004712,protein serine/threonine/tyrosine kinase activity;GO:0106311,protein threonine kinase activity;GO:0008134,transcription factor binding;GO:0016301,kinase activity;GO:0004672,protein kinase activity	GO:0071276,cellular response to cadmium ion;GO:0034614,cellular response to reactive oxygen species;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0035556,intracellular signal transduction;GO:0007254,JNK cascade;GO:0018105,peptidyl-serine phosphorylation;GO:2001235,positive regulation of apoptotic signaling pathway;GO:0010628,positive regulation of gene expression;GO:0010744,positive regulation of macrophage derived foam cell differentiation;GO:0071803,positive regulation of podosome assembly;GO:0031398,positive regulation of protein ubiquitination;GO:1901485,positive regulation of transcription factor catabolic process;GO:0061833,protein localization to tricellular tight junction;GO:0006468,protein phosphorylation;GO:0042752,regulation of circadian rhythm;GO:0051090,regulation of DNA-binding transcription factor activity;GO:0048511,rhythmic process	hsa:5601,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:5601,path:hsa04014,Ras signaling pathway;hsa:5601,path:hsa04010,MAPK signaling pathway;hsa:5601,path:hsa04012,ErbB signaling pathway;hsa:5601,path:hsa04310,Wnt signaling pathway;hsa:5601,path:hsa04668,TNF signaling pathway;hsa:5601,path:hsa04068,FoxO signaling pathway;hsa:5601,path:hsa04071,Sphingolipid signaling pathway;hsa:5601,path:hsa04024,cAMP signaling pathway;hsa:5601,path:hsa04140,Autophagy - animal;hsa:5601,path:hsa04137,Mitophagy - animal;hsa:5601,path:hsa04210,Apoptosis;hsa:5601,path:hsa04215,Apoptosis - multiple species;hsa:5601,path:hsa04217,Necroptosis;hsa:5601,path:hsa04510,Focal adhesion;hsa:5601,path:hsa04530,Tight junction;hsa:5601,path:hsa04620,Toll-like receptor signaling pathway;hsa:5601,path:hsa04621,NOD-like receptor signaling pathway;hsa:5601,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:5601,path:hsa04625,C-type lectin receptor signaling pathway;hsa:5601,path:hsa04660,T cell receptor signaling pathway;hsa:5601,path:hsa04658,Th1 and Th2 cell differentiation;hsa:5601,path:hsa04659,Th17 cell differentiation;hsa:5601,path:hsa04657,IL-17 signaling pathway;hsa:5601,path:hsa04664,Fc epsilon RI signaling pathway;hsa:5601,path:hsa04910,Insulin signaling pathway;hsa:5601,path:hsa04920,Adipocytokine signaling pathway;hsa:5601,path:hsa04912,GnRH signaling pathway;hsa:5601,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:5601,path:hsa04917,Prolactin signaling pathway;hsa:5601,path:hsa04926,Relaxin signaling pathway;hsa:5601,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:5601,path:hsa04728,Dopaminergic synapse;hsa:5601,path:hsa04723,Retrograde endocannabinoid signaling;hsa:5601,path:hsa04722,Neurotrophin signaling pathway;hsa:5601,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:5601,path:hsa04380,Osteoclast differentiation;hsa:5601,path:hsa05200,Pathways in cancer;hsa:5601,path:hsa05231,Choline metabolism in cancer;hsa:5601,path:hsa05210,Colorectal cancer;hsa:5601,path:hsa05212,Pancreatic cancer;hsa:5601,path:hsa05017,Spinocerebellar ataxia;hsa:5601,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:5601,path:hsa04930,Type II diabetes mellitus;hsa:5601,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:5601,path:hsa04931,Insulin resistance;hsa:5601,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:5601,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:5601,path:hsa05130,Pathogenic Escherichia coli infection;hsa:5601,path:hsa05132,Salmonella infection;hsa:5601,path:hsa05131,Shigellosis;hsa:5601,path:hsa05135,Yersinia infection;hsa:5601,path:hsa05133,Pertussis;hsa:5601,path:hsa05152,Tuberculosis;hsa:5601,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:5601,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:5601,path:hsa05162,Measles;hsa:5601,path:hsa05161,Hepatitis B;hsa:5601,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:5601,path:hsa05169,Epstein-Barr virus infection;hsa:5601,path:hsa05145,Toxoplasmosis;hsa:5601,path:hsa05142,Chagas disease (American trypanosomiasis);hsa:5601,path:hsa01522,Endocrine resistance
STAG2_HUMAN	Q8N3U4	STAG2	Cohesin subunit SA-2	0.392562022	0.209796612	0.379897366	0.277862022	0.301179317	0.328879694	0.301179317	0.328879694	0.915773525987287	0.462678	0	1.09197303877278	0.462545	0	GO:0000785,chromatin;GO:0005694,chromosome;GO:0000775,chromosome, centromeric region;GO:0008278,cohesin complex;GO:0005829,cytosol;GO:0016020,membrane;GO:0097431,mitotic spindle pole;GO:0016363,nuclear matrix;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003682,chromatin binding	GO:0051301,cell division;GO:0051321,meiotic cell cycle;GO:0090307,mitotic spindle assembly;GO:0007062,sister chromatid cohesion	hsa:10735,path:hsa04110,Cell cycle
SPCS2_HUMAN	Q15005	SPCS2	Signal peptidase complex subunit 2	5.493574044	6.412763998	1.120921895	0.242456612	5.953169021	0.6816892535	5.953169021	0.6816892535	8.73296592316018	0.023053	1	0.11450863415692	0.022804	-1	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0005787,signal peptidase complex	GO:0008233,peptidase activity	GO:0045047,protein targeting to ER;GO:0006465,signal peptide processing	hsa:9789,path:hsa03060,Protein export
TCPB_HUMAN	P78371	CCT2	T-complex protein 1 subunit beta	11.16351405	5.358790694	13.70735859	19.50317472	8.261152372	16.605266655	8.261152372	16.605266655	0.497501939814528	0.222850	0	2.0100424138503	0.223180	0	GO:0035578,azurophil granule lumen;GO:0044297,cell body;GO:0005832,chaperonin-containing T-complex;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005874,microtubule;GO:0002199,zona pellucida receptor complex	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0044183,protein folding chaperone;GO:0031625,ubiquitin protein ligase binding;GO:0051082,unfolded protein binding	GO:0007339,binding of sperm to zona pellucida;GO:0051086,chaperone mediated protein folding independent of cofactor;GO:0051131,chaperone-mediated protein complex assembly;GO:0043312,neutrophil degranulation;GO:1904851,positive regulation of establishment of protein localization to telomere;GO:1904871,positive regulation of protein localization to Cajal body;GO:0051973,positive regulation of telomerase activity;GO:1904874,positive regulation of telomerase RNA localization to Cajal body;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:0006457,protein folding;GO:0050821,protein stabilization;GO:0090666,scaRNA localization to Cajal body;GO:1901998,toxin transport	
RAB2B_HUMAN	Q8WUD1	RAB2B	Ras-related protein Rab-2B	0.050804724	0.160098911	0.011990992	2.55E-05	0.1054518175	0.006008246	0.1054518175	0.006008246	17.5511817425585	0.004901	1	0.0569762204430474	0.004818	-1	GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005886,plasma membrane;GO:0098793,presynapse	GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0045921,positive regulation of exocytosis;GO:0015031,protein transport;GO:0016192,vesicle-mediated transport	
CALM3_HUMAN	P0DP25	CALM3	Calmodulin-3	1.533256215	3.746337085	0.033707616	0.003510845	2.63979665	0.0186092305	2.63979665	0.0186092305	141.854154044682	0.000007	1	0.00704949394492186	0.000007	-1	GO:0034704,calcium channel complex;GO:1902494,catalytic complex;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0030426,growth cone;GO:0031966,mitochondrial membrane;GO:0043209,myelin sheath;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0030017,sarcomere;GO:0005876,spindle microtubule;GO:0000922,spindle pole;GO:0030672,synaptic vesicle membrane;GO:0031982,vesicle;GO:0008076,voltage-gated potassium channel complex	GO:0010856,adenylate cyclase activator activity;GO:0008179,adenylate cyclase binding;GO:0005509,calcium ion binding;GO:0048306,calcium-dependent protein binding;GO:0097718,disordered domain specific binding;GO:0030234,enzyme regulator activity;GO:0044325,ion channel binding;GO:0031997,N-terminal myristoylation domain binding;GO:0050998,nitric-oxide synthase binding;GO:0030235,nitric-oxide synthase regulator activity;GO:0043548,phosphatidylinositol 3-kinase binding;GO:0019904,protein domain specific binding;GO:0019901,protein kinase binding;GO:0072542,protein phosphatase activator activity;GO:0043539,protein serine/threonine kinase activator activity;GO:0031432,titin binding;GO:0031800,type 3 metabotropic glutamate receptor binding	GO:0007190,activation of adenylate cyclase activity;GO:0005513,detection of calcium ion;GO:0090151,establishment of protein localization to mitochondrial membrane;GO:0007186,G protein-coupled receptor signaling pathway;GO:0000086,G2/M transition of mitotic cell cycle;GO:1901842,negative regulation of high voltage-gated calcium channel activity;GO:0010801,negative regulation of peptidyl-threonine phosphorylation;GO:0060315,negative regulation of ryanodine-sensitive calcium-release channel activity;GO:0051343,positive regulation of cyclic-nucleotide phosphodiesterase activity;GO:0043388,positive regulation of DNA binding;GO:0051000,positive regulation of nitric-oxide synthase activity;GO:0010800,positive regulation of peptidyl-threonine phosphorylation;GO:0032516,positive regulation of phosphoprotein phosphatase activity;GO:0031954,positive regulation of protein autophosphorylation;GO:0035307,positive regulation of protein dephosphorylation;GO:0071902,positive regulation of protein serine/threonine kinase activity;GO:0060316,positive regulation of ryanodine-sensitive calcium-release channel activity;GO:0098901,regulation of cardiac muscle cell action potential;GO:0055117,regulation of cardiac muscle contraction;GO:0010881,regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:1901844,regulation of cell communication by electrical coupling involved in cardiac conduction;GO:0032465,regulation of cytokinesis;GO:0002027,regulation of heart rate;GO:0010880,regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:1900242,regulation of synaptic vesicle endocytosis;GO:2000300,regulation of synaptic vesicle exocytosis;GO:0001975,response to amphetamine;GO:0051592,response to calcium ion;GO:0051412,response to corticosterone;GO:0021762,substantia nigra development	hsa:801,path:hsa04014,Ras signaling pathway;hsa:801,path:hsa04015,Rap1 signaling pathway;hsa:801,path:hsa04371,Apelin signaling pathway;hsa:801,path:hsa04020,Calcium signaling pathway;hsa:801,path:hsa04070,Phosphatidylinositol signaling system;hsa:801,path:hsa04024,cAMP signaling pathway;hsa:801,path:hsa04022,cGMP-PKG signaling pathway;hsa:801,path:hsa04114,Oocyte meiosis;hsa:801,path:hsa04218,Cellular senescence;hsa:801,path:hsa04625,C-type lectin receptor signaling pathway;hsa:801,path:hsa04910,Insulin signaling pathway;hsa:801,path:hsa04922,Glucagon signaling pathway;hsa:801,path:hsa04912,GnRH signaling pathway;hsa:801,path:hsa04915,Estrogen signaling pathway;hsa:801,path:hsa04921,Oxytocin signaling pathway;hsa:801,path:hsa04916,Melanogenesis;hsa:801,path:hsa04924,Renin secretion;hsa:801,path:hsa04925,Aldosterone synthesis and secretion;hsa:801,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:801,path:hsa04270,Vascular smooth muscle contraction;hsa:801,path:hsa04970,Salivary secretion;hsa:801,path:hsa04971,Gastric acid secretion;hsa:801,path:hsa04728,Dopaminergic synapse;hsa:801,path:hsa04720,Long-term potentiation;hsa:801,path:hsa04722,Neurotrophin signaling pathway;hsa:801,path:hsa04744,Phototransduction;hsa:801,path:hsa04740,Olfactory transduction;hsa:801,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:801,path:hsa04713,Circadian entrainment;hsa:801,path:hsa05200,Pathways in cancer;hsa:801,path:hsa05214,Glioma;hsa:801,path:hsa05010,Alzheimer disease;hsa:801,path:hsa05031,Amphetamine addiction;hsa:801,path:hsa05034,Alcoholism;hsa:801,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:801,path:hsa05133,Pertussis;hsa:801,path:hsa05152,Tuberculosis;hsa:801,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:801,path:hsa05163,Human cytomegalovirus infection;hsa:801,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:805,path:hsa04014,Ras signaling pathway;hsa:805,path:hsa04015,Rap1 signaling pathway;hsa:805,path:hsa04371,Apelin signaling pathway;hsa:805,path:hsa04020,Calcium signaling pathway;hsa:805,path:hsa04070,Phosphatidylinositol signaling system;hsa:805,path:hsa04024,cAMP signaling pathway;hsa:805,path:hsa04022,cGMP-PKG signaling pathway;hsa:805,path:hsa04114,Oocyte meiosis;hsa:805,path:hsa04218,Cellular senescence;hsa:805,path:hsa04625,C-type lectin receptor signaling pathway;hsa:805,path:hsa04910,Insulin signaling pathway;hsa:805,path:hsa04922,Glucagon signaling pathway;hsa:805,path:hsa04912,GnRH signaling pathway;hsa:805,path:hsa04915,Estrogen signaling pathway;hsa:805,path:hsa04921,Oxytocin signaling pathway;hsa:805,path:hsa04916,Melanogenesis;hsa:805,path:hsa04924,Renin secretion;hsa:805,path:hsa04925,Aldosterone synthesis and secretion;hsa:805,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:805,path:hsa04270,Vascular smooth muscle contraction;hsa:805,path:hsa04970,Salivary secretion;hsa:805,path:hsa04971,Gastric acid secretion;hsa:805,path:hsa04728,Dopaminergic synapse;hsa:805,path:hsa04720,Long-term potentiation;hsa:805,path:hsa04722,Neurotrophin signaling pathway;hsa:805,path:hsa04744,Phototransduction;hsa:805,path:hsa04740,Olfactory transduction;hsa:805,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:805,path:hsa04713,Circadian entrainment;hsa:805,path:hsa05200,Pathways in cancer;hsa:805,path:hsa05214,Glioma;hsa:805,path:hsa05010,Alzheimer disease;hsa:805,path:hsa05031,Amphetamine addiction;hsa:805,path:hsa05034,Alcoholism;hsa:805,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:805,path:hsa05133,Pertussis;hsa:805,path:hsa05152,Tuberculosis;hsa:805,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:805,path:hsa05163,Human cytomegalovirus infection;hsa:805,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:808,path:hsa04014,Ras signaling pathway;hsa:808,path:hsa04015,Rap1 signaling pathway;hsa:808,path:hsa04371,Apelin signaling pathway;hsa:808,path:hsa04020,Calcium signaling pathway;hsa:808,path:hsa04070,Phosphatidylinositol signaling system;hsa:808,path:hsa04024,cAMP signaling pathway;hsa:808,path:hsa04022,cGMP-PKG signaling pathway;hsa:808,path:hsa04114,Oocyte meiosis;hsa:808,path:hsa04218,Cellular senescence;hsa:808,path:hsa04625,C-type lectin receptor signaling pathway;hsa:808,path:hsa04910,Insulin signaling pathway;hsa:808,path:hsa04922,Glucagon signaling pathway;hsa:808,path:hsa04912,GnRH signaling pathway;hsa:808,path:hsa04915,Estrogen signaling pathway;hsa:808,path:hsa04921,Oxytocin signaling pathway;hsa:808,path:hsa04916,Melanogenesis;hsa:808,path:hsa04924,Renin secretion;hsa:808,path:hsa04925,Aldosterone synthesis and secretion;hsa:808,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:808,path:hsa04270,Vascular smooth muscle contraction;hsa:808,path:hsa04970,Salivary secretion;hsa:808,path:hsa04971,Gastric acid secretion;hsa:808,path:hsa04728,Dopaminergic synapse;hsa:808,path:hsa04720,Long-term potentiation;hsa:808,path:hsa04722,Neurotrophin signaling pathway;hsa:808,path:hsa04744,Phototransduction;hsa:808,path:hsa04740,Olfactory transduction;hsa:808,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:808,path:hsa04713,Circadian entrainment;hsa:808,path:hsa05200,Pathways in cancer;hsa:808,path:hsa05214,Glioma;hsa:808,path:hsa05010,Alzheimer disease;hsa:808,path:hsa05031,Amphetamine addiction;hsa:808,path:hsa05034,Alcoholism;hsa:808,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:808,path:hsa05133,Pertussis;hsa:808,path:hsa05152,Tuberculosis;hsa:808,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:808,path:hsa05163,Human cytomegalovirus infection;hsa:808,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection
SHOT1_HUMAN	A0MZ66	SHTN1	Shootin-1	0.286279509	0.233987376	0.432091058	0.16573621	0.2601334425	0.298913634	0.2601334425	0.298913634	0.870262888376647	0.479773	0	1.14907806980642	0.479677	0	GO:0030424,axon;GO:0044295,axonal growth cone;GO:0031252,cell leading edge;GO:0005737,cytoplasm;GO:0030175,filopodium;GO:0030426,growth cone;GO:0030027,lamellipodium;GO:0005874,microtubule;GO:0005875,microtubule associated complex;GO:0015630,microtubule cytoskeleton;GO:0043204,perikaryon;GO:0048471,perinuclear region of cytoplasm	GO:0051015,actin filament binding;GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0019894,kinesin binding	GO:0061573,actin filament bundle retrograde transport;GO:0007409,axonogenesis;GO:0032488,Cdc42 protein signal transduction;GO:0060327,cytoplasmic actin-based contraction involved in cell motility;GO:0061163,endoplasmic reticulum polarization;GO:0038007,netrin-activated signaling pathway;GO:0048812,neuron projection morphogenesis;GO:0045773,positive regulation of axon extension;GO:2001224,positive regulation of neuron migration;GO:0007265,Ras protein signal transduction;GO:2000114,regulation of establishment of cell polarity;GO:0006930,substrate-dependent cell migration, cell extension	
CRTAP_HUMAN	O75718	CRTAP	Cartilage-associated protein	0.852277378	1.158832396	0.765183532	0.198941648	1.005554887	0.48206259	1.005554887	0.48206259	2.08594258890739	0.215483	0	0.479399579507986	0.214932	0	GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005615,extracellular space;GO:0032991,protein-containing complex		GO:0061077,chaperone-mediated protein folding;GO:0030199,collagen fibril organization;GO:1901874,negative regulation of post-translational protein modification;GO:0018400,peptidyl-proline hydroxylation to 3-hydroxy-L-proline;GO:0050821,protein stabilization;GO:0007283,spermatogenesis	
HARS1_HUMAN	P12081	HARS1	Histidine--tRNA ligase, cytoplasmic	4.058229647	3.261811948	4.067399643	4.515519853	3.6600207975	4.291459748	3.6600207975	4.291459748	0.852861499914038	0.486558	0	1.17252332307273	0.486478	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0004821,histidine-tRNA ligase activity;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:0004812,aminoacyl-tRNA ligase activity	GO:0006427,histidyl-tRNA aminoacylation;GO:0032543,mitochondrial translation;GO:0006412,translation;GO:0006418,tRNA aminoacylation for protein translation	hsa:3035,path:hsa00970,Aminoacyl-tRNA biosynthesis
TWF2_HUMAN	Q6IBS0	TWF2	Twinfilin-2	0.964296806	0.921706622	1.879428823	1.109567819	0.943001714	1.494498321	0.943001714	1.494498321	0.630982116707242	0.344807	0	1.58483096988305	0.345060	0	GO:0005884,actin filament;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0030175,filopodium;GO:0030426,growth cone;GO:0030027,lamellipodium;GO:0030016,myofibril;GO:0048471,perinuclear region of cytoplasm;GO:0032420,stereocilium;GO:0005856,cytoskeleton	GO:0051015,actin filament binding;GO:0003785,actin monomer binding;GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding;GO:0005080,protein kinase C binding;GO:0003723,RNA binding;GO:0003779,actin binding	GO:0030042,actin filament depolymerization;GO:0051016,barbed-end actin filament capping;GO:0030030,cell projection organization;GO:0071363,cellular response to growth factor stimulus;GO:0071300,cellular response to retinoic acid;GO:0030837,negative regulation of actin filament polymerization;GO:0045773,positive regulation of axon extension;GO:0010592,positive regulation of lamellipodium assembly;GO:0010976,positive regulation of neuron projection development;GO:0032956,regulation of actin cytoskeleton organization;GO:0010591,regulation of lamellipodium assembly;GO:0032532,regulation of microvillus length;GO:0042989,sequestering of actin monomers	
ABHEB_HUMAN	Q96IU4	ABHD14B	Protein ABHD14B	0.979676857	6.51539009	0.178001748	0.115058631	3.7475334735	0.1465301895	3.7475334735	0.1465301895	25.5751629496118	0.001865	1	0.0391004351358464	0.001826	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0016787,hydrolase activity	GO:0050427,3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0045944,positive regulation of transcription by RNA polymerase II	
NPS3A_HUMAN	Q9UFN0	NIPSNAP3A	Protein NipSnap homolog 3A	3.13988415	1.471823119	1.3227109	2.364140545	2.3058536345	1.8434257225	2.3058536345	1.8434257225	1.25085247881475	0.360732	0	0.799454785385685	0.360387	0	GO:0005829,cytosol;GO:0005739,mitochondrion;GO:0005634,nucleus			
RL24_HUMAN	P83731	RPL24	60S ribosomal protein L24	0.386286885	0.318273091	0.169889488	0.082654744	0.352279988	0.126272116	0.352279988	0.126272116	2.78984782356859	0.150892	0	0.358442489784574	0.150324	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0042788,polysomal ribosome;GO:0045202,synapse;GO:0005840,ribosome	GO:0045296,cadherin binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:1902626,assembly of large subunit precursor of preribosome;GO:0002181,cytoplasmic translation;GO:0010458,exit from mitosis;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0021554,optic nerve development;GO:0060041,retina development in camera-type eye;GO:0031290,retinal ganglion cell axon guidance;GO:0000027,ribosomal large subunit assembly;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6152,path:hsa03010,Ribosome
STK39_HUMAN	Q9UEW8	STK39	STE20/SPS1-related proline-alanine-rich protein kinase	0.093742669	0.055996469	0.051176028	0.037557228	0.074869569	0.044366628	0.074869569	0.044366628	1.68751993052075	0.271300	0	0.592585593754386	0.270808	0	GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0019898,extrinsic component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005654,nucleoplasm	GO:0005524,ATP binding;GO:0016301,kinase activity;GO:0019901,protein kinase binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity	GO:0000187,activation of MAPK activity;GO:0071476,cellular hypotonic response;GO:1990869,cellular response to chemokine;GO:0038146,chemokine (C-X-C motif) ligand 12 signaling pathway;GO:0035556,intracellular signal transduction;GO:0050801,ion homeostasis;GO:0036438,maintenance of lens transparency;GO:1905408,negative regulation of creatine transmembrane transporter activity;GO:0090188,negative regulation of pancreatic juice secretion;GO:1901380,negative regulation of potassium ion transmembrane transport;GO:1901017,negative regulation of potassium ion transmembrane transporter activity;GO:2000650,negative regulation of sodium ion transmembrane transporter activity;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:0032414,positive regulation of ion transmembrane transporter activity;GO:0043268,positive regulation of potassium ion transport;GO:0010820,positive regulation of T cell chemotaxis;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:0008217,regulation of blood pressure;GO:0050727,regulation of inflammatory response;GO:0007165,signal transduction	
LRBA_HUMAN	P50851	LRBA	Lipopolysaccharide-responsive and beige-like anchor protein	1.705086906	1.245024733	1.888526323	1.499499298	1.4750558195	1.6940128105	1.4750558195	1.6940128105	0.87074655537264	0.479586	0	1.14843980011158	0.479490	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane;GO:0005764,lysosome;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0019901,protein kinase binding	GO:0008104,protein localization	
EMIL1_HUMAN	Q9Y6C2	EMILIN1	EMILIN-1	12.85958198	10.25701394	8.472091233	38.94304067	11.55829796	23.7075659515	11.55829796	23.7075659515	0.487536256722664	0.213736	0	2.05112950311068	0.214068	0	GO:0005581,collagen trimer;GO:0062023,collagen-containing extracellular matrix;GO:1990971,EMILIN complex;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0034668,integrin alpha4-beta1 complex	GO:0030023,extracellular matrix constituent conferring elasticity;GO:0042802,identical protein binding;GO:0098640,integrin binding involved in cell-matrix adhesion	GO:0003180,aortic valve morphogenesis;GO:0007155,cell adhesion;GO:0016477,cell migration;GO:0007160,cell-matrix adhesion;GO:0048251,elastic fiber assembly;GO:0016525,negative regulation of angiogenesis;GO:0050866,negative regulation of cell activation;GO:0032966,negative regulation of collagen biosynthetic process;GO:1904027,negative regulation of collagen fibril organization;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:0010629,negative regulation of gene expression;GO:1905522,negative regulation of macrophage migration;GO:0060394,negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030948,negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0010811,positive regulation of cell-substrate adhesion;GO:1901203,positive regulation of extracellular matrix assembly;GO:0010628,positive regulation of gene expression	
ABCD1_HUMAN	P33897	ABCD1	ATP-binding cassette sub-family D member 1	0.153928474	0.172859801	0.18352082	0.12877839	0.1633941375	0.156149605	0.1633941375	0.156149605	1.0463948179696	0.418367	0	0.95566222502934	0.418138	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0005779,integral component of peroxisomal membrane;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0031966,mitochondrial membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005778,peroxisomal membrane;GO:0005777,peroxisome;GO:0016021,integral component of membrane	GO:0015607,ABC-type fatty-acyl-CoA transporter activity;GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0042626,ATPase-coupled transmembrane transporter activity;GO:0019899,enzyme binding;GO:0042802,identical protein binding;GO:0005324,long-chain fatty acid transporter activity;GO:0042803,protein homodimerization activity	GO:0036109,alpha-linolenic acid metabolic process;GO:0006635,fatty acid beta-oxidation;GO:0033540,fatty acid beta-oxidation using acyl-CoA oxidase;GO:0030497,fatty acid elongation;GO:0055089,fatty acid homeostasis;GO:0043651,linoleic acid metabolic process;GO:0006869,lipid transport;GO:0042758,long-chain fatty acid catabolic process;GO:0015910,long-chain fatty acid import into peroxisome;GO:0043217,myelin maintenance;GO:1900016,negative regulation of cytokine production involved in inflammatory response;GO:1903427,negative regulation of reactive oxygen species biosynthetic process;GO:1990535,neuron projection maintenance;GO:0015919,peroxisomal membrane transport;GO:0007031,peroxisome organization;GO:0032000,positive regulation of fatty acid beta-oxidation;GO:2001280,positive regulation of unsaturated fatty acid biosynthetic process;GO:0045046,protein import into peroxisome membrane;GO:1900407,regulation of cellular response to oxidative stress;GO:0031998,regulation of fatty acid beta-oxidation;GO:0051900,regulation of mitochondrial depolarization;GO:0002082,regulation of oxidative phosphorylation;GO:0055092,sterol homeostasis;GO:0042760,very long-chain fatty acid catabolic process;GO:0036113,very long-chain fatty-acyl-CoA catabolic process	hsa:215,path:hsa02010,ABC transporters;hsa:215,path:hsa04146,Peroxisome
PSMD3_HUMAN	O43242	PSMD3	26S proteasome non-ATPase regulatory subunit 3	4.638328344	4.363011119	6.67231169	18.43851263	4.5006697315	12.55541216	4.5006697315	12.55541216	0.358464515074908	0.103204	0	2.78967640574139	0.103506	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0022624,proteasome accessory complex;GO:0000502,proteasome complex;GO:0008541,proteasome regulatory particle, lid subcomplex;GO:0034774,secretory granule lumen	GO:0030234,enzyme regulator activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0043312,neutrophil degranulation;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0042176,regulation of protein catabolic process;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5709,path:hsa03050,Proteasome;hsa:5709,path:hsa05169,Epstein-Barr virus infection
ODP2_HUMAN	P10515	DLAT	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	1.106956521	1.253713045	2.326864078	1.48670847	1.180334783	1.906786274	1.180334783	1.906786274	0.619017872686868	0.334095	0	1.61546224127498	0.334357	0	GO:0043231,intracellular membrane-bounded organelle;GO:0005759,mitochondrial matrix;GO:0005967,mitochondrial pyruvate dehydrogenase complex;GO:0005739,mitochondrion;GO:0045254,pyruvate dehydrogenase complex	GO:0004742,dihydrolipoyllysine-residue acetyltransferase activity;GO:0042802,identical protein binding	GO:0006086,acetyl-CoA biosynthetic process from pyruvate;GO:0006006,glucose metabolic process;GO:0006090,pyruvate metabolic process;GO:0030431,sleep;GO:0006099,tricarboxylic acid cycle	hsa:1737,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:1737,path:hsa00020,Citrate cycle (TCA cycle);hsa:1737,path:hsa00620,Pyruvate metabolism
OXLA_HUMAN	Q96RQ9	IL4I1	L-amino-acid oxidase	1.234887191	2.040333865	0.946286683	1.298912982	1.637610528	1.1225998325	1.637610528	1.1225998325	1.45876605410949	0.313446	0	0.685510878994544	0.313017	0	GO:0001669,acrosomal vesicle;GO:0005576,extracellular region;GO:0001772,immunological synapse;GO:0005764,lysosome;GO:0097225,sperm midpiece	GO:0001716,L-amino-acid oxidase activity;GO:0106329,L-phenylalaine oxidase activity;GO:0016491,oxidoreductase activity;GO:0046592,polyamine oxidase activity	GO:0002250,adaptive immune response;GO:0009063,cellular amino acid catabolic process;GO:0006559,L-phenylalanine catabolic process;GO:0006558,L-phenylalanine metabolic process;GO:0050868,negative regulation of T cell activation;GO:0002841,negative regulation of T cell mediated immune response to tumor cell;GO:0042130,negative regulation of T cell proliferation;GO:0045591,positive regulation of regulatory T cell differentiation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0002819,regulation of adaptive immune response;GO:0045577,regulation of B cell differentiation;GO:0006569,tryptophan catabolic process;GO:0019440,tryptophan catabolic process to indole-3-acetate;GO:0006572,tyrosine catabolic process	hsa:259307,path:hsa00250,Alanine, aspartate and glutamate metabolism;hsa:259307,path:hsa00270,Cysteine and methionine metabolism;hsa:259307,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:259307,path:hsa00350,Tyrosine metabolism;hsa:259307,path:hsa00360,Phenylalanine metabolism;hsa:259307,path:hsa00380,Tryptophan metabolism;hsa:259307,path:hsa00400,Phenylalanine, tyrosine and tryptophan biosynthesis
NEXN_HUMAN	Q0ZGT2	NEXN	Nexilin	0.764452996	0.415752082	0.396222987	0.681171999	0.590102539	0.538697493	0.590102539	0.538697493	1.09542469877431	0.403356	0	0.912887943022391	0.403096	0	GO:0015629,actin cytoskeleton;GO:0005912,adherens junction;GO:0030424,axon;GO:0005925,focal adhesion;GO:0005886,plasma membrane;GO:0030018,Z disc	GO:0051015,actin filament binding;GO:0098632,cell-cell adhesion mediator activity;GO:0008307,structural constituent of muscle	GO:0007411,axon guidance;GO:0070593,dendrite self-avoidance;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0030334,regulation of cell migration;GO:0051493,regulation of cytoskeleton organization;GO:0007155,cell adhesion	
DHC24_HUMAN	Q15392	DHCR24	Delta(24)-sterol reductase	0.148089762	0.65508409	0.284538817	0.593515393	0.401586926	0.439027105	0.401586926	0.439027105	0.914720119615394	0.463064	0	1.09323057245145	0.462932	0	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005634,nucleus;GO:0005856,cytoskeleton;GO:0005829,cytosol	GO:0000246,delta24(24-1) sterol reductase activity;GO:0050614,delta24-sterol reductase activity;GO:0019899,enzyme binding;GO:0071949,FAD binding;GO:0016628,oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0042605,peptide antigen binding	GO:0006915,apoptotic process;GO:0007050,cell cycle arrest;GO:0006695,cholesterol biosynthetic process;GO:0033489,cholesterol biosynthetic process via desmosterol;GO:0033490,cholesterol biosynthetic process via lathosterol;GO:0043066,negative regulation of apoptotic process;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:1901214,regulation of neuron death;GO:0006979,response to oxidative stress;GO:0043588,skin development;GO:0008202,steroid metabolic process;GO:0009888,tissue development;GO:0042987,amyloid precursor protein catabolic process;GO:0030539,male genitalia development;GO:0061024,membrane organization;GO:0008285,negative regulation of cell population proliferation;GO:0031639,plasminogen activation;GO:0008104,protein localization;GO:0007265,Ras protein signal transduction;GO:0009725,response to hormone	hsa:1718,path:hsa00100,Steroid biosynthesis
VAMP2_HUMAN	P63027	VAMP2	Vesicle-associated membrane protein 2	0.915840087	1.175065133	0.378107531	0.676993642	1.04545261	0.5275505865	1.04545261	0.5275505865	1.98171063923175	0.228337	0	0.50461453867335	0.227797	0	GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0030136,clathrin-coated vesicle;GO:0061202,clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane;GO:0060203,clathrin-sculpted glutamate transport vesicle membrane;GO:0070083,clathrin-sculpted monoamine transport vesicle membrane;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005887,integral component of plasma membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0043005,neuron projection;GO:0044306,neuron projection terminus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0030141,secretory granule;GO:0030667,secretory granule membrane;GO:0031201,SNARE complex;GO:0045202,synapse;GO:0008021,synaptic vesicle;GO:0030672,synaptic vesicle membrane;GO:0070044,synaptobrevin 2-SNAP-25-syntaxin-1a complex;GO:0070032,synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex;GO:0070033,synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex;GO:0005802,trans-Golgi network;GO:0031982,vesicle;GO:0042589,zymogen granule membrane;GO:0016021,integral component of membrane	GO:0048306,calcium-dependent protein binding;GO:0005516,calmodulin binding;GO:0005543,phospholipid binding;GO:0043621,protein self-association;GO:0005484,SNAP receptor activity;GO:0000149,SNARE binding;GO:0019905,syntaxin binding;GO:0017075,syntaxin-1 binding	GO:0017156,calcium-ion regulated exocytosis;GO:0032869,cellular response to insulin stimulus;GO:0043308,eosinophil degranulation;GO:0006887,exocytosis;GO:0043001,Golgi to plasma membrane protein transport;GO:0060291,long-term synaptic potentiation;GO:0061025,membrane fusion;GO:0061024,membrane organization;GO:0007269,neurotransmitter secretion;GO:0006836,neurotransmitter transport;GO:0090316,positive regulation of intracellular protein transport;GO:0006892,post-Golgi vesicle-mediated transport;GO:0045048,protein insertion into ER membrane;GO:0015031,protein transport;GO:0065003,protein-containing complex assembly;GO:1902259,regulation of delayed rectifier potassium channel activity;GO:0017157,regulation of exocytosis;GO:0060627,regulation of vesicle-mediated transport;GO:0009749,response to glucose;GO:0035493,SNARE complex assembly;GO:0048488,synaptic vesicle endocytosis;GO:0016079,synaptic vesicle exocytosis;GO:0006906,vesicle fusion;GO:0016192,vesicle-mediated transport	hsa:6844,path:hsa04130,SNARE interactions in vesicular transport;hsa:6844,path:hsa04911,Insulin secretion;hsa:6844,path:hsa04970,Salivary secretion;hsa:6844,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:6844,path:hsa04721,Synaptic vesicle cycle
CEPT1_HUMAN	Q9Y6K0	CEPT1	Choline/ethanolaminephosphotransferase 1	0.149643038	0.118967153	0.181743623	0.185408267	0.1343050955	0.183575945	0.1343050955	0.183575945	0.7316050885643	0.431224	0	1.3668576334842	0.431391	0	GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane;GO:0031965,nuclear membrane	GO:0004142,diacylglycerol cholinephosphotransferase activity;GO:0004307,ethanolaminephosphotransferase activity;GO:0046872,metal ion binding;GO:0016780,phosphotransferase activity, for other substituted phosphate groups	GO:0006629,lipid metabolic process;GO:0006656,phosphatidylcholine biosynthetic process;GO:0006646,phosphatidylethanolamine biosynthetic process;GO:0008654,phospholipid biosynthetic process	hsa:10390,path:hsa00564,Glycerophospholipid metabolism;hsa:10390,path:hsa00565,Ether lipid metabolism;hsa:10390,path:hsa00440,Phosphonate and phosphinate metabolism
S10A6_HUMAN	P06703	S100A6	Protein S100-A6	38.3304022	2.733180225	4.544478744	40.94801877	20.5317912125	22.746248757	20.5317912125	22.746248757	0.902645154013867	0.467515	0	1.1078550586055	0.467393	0	GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0005635,nuclear envelope;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0001726,ruffle	GO:0005509,calcium ion binding;GO:0048306,calcium-dependent protein binding;GO:0015075,ion transmembrane transporter activity;GO:0042803,protein homodimerization activity;GO:0044548,S100 protein binding;GO:0005523,tropomyosin binding;GO:0008270,zinc ion binding	GO:0007409,axonogenesis;GO:0048146,positive regulation of fibroblast proliferation;GO:0007165,signal transduction	
IDHP_HUMAN	P48735	IDH2	Isocitrate dehydrogenase [NADP], mitochondrial	28.72722623	16.57265539	32.76527387	17.24420879	22.64994081	25.00474133	22.64994081	25.00474133	0.905825839630871	0.466336	0	1.10396497455571	0.466211	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005777,peroxisome	GO:0004450,isocitrate dehydrogenase (NADP+) activity;GO:0000287,magnesium ion binding;GO:0051287,NAD binding	GO:0006103,2-oxoglutarate metabolic process;GO:0005975,carbohydrate metabolic process;GO:0006097,glyoxylate cycle;GO:0006102,isocitrate metabolic process;GO:0006741,NADP biosynthetic process;GO:0006739,NADP metabolic process;GO:1903976,negative regulation of glial cell migration;GO:0060253,negative regulation of glial cell proliferation;GO:1904465,negative regulation of matrix metallopeptidase secretion;GO:0006099,tricarboxylic acid cycle	hsa:3418,path:hsa00020,Citrate cycle (TCA cycle);hsa:3418,path:hsa00480,Glutathione metabolism;hsa:3418,path:hsa04146,Peroxisome
TPP2_HUMAN	P29144	TPP2	Tripeptidyl-peptidase 2	2.166435384	2.270105727	3.239934746	3.040075449	2.2182705555	3.1400050975	2.2182705555	3.1400050975	0.706454444060023	0.410321	0	1.41551944135698	0.410511	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016604,nuclear body;GO:0005654,nucleoplasm	GO:0004177,aminopeptidase activity;GO:0004175,endopeptidase activity;GO:0042802,identical protein binding;GO:0004252,serine-type endopeptidase activity;GO:0008240,tripeptidyl-peptidase activity;GO:0042277,peptide binding	GO:0000209,protein polyubiquitination;GO:0006508,proteolysis	
PLOD3_HUMAN	O60568	PLOD3	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3	1.08782098	1.442249319	1.062363286	1.259874032	1.2650351495	1.161118659	1.2650351495	1.161118659	1.08949687415195	0.405128	0	0.917854859178361	0.404872	0	GO:0062023,collagen-containing extracellular matrix;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005794,Golgi apparatus;GO:0005791,rough endoplasmic reticulum;GO:0005802,trans-Golgi network	GO:0005506,iron ion binding;GO:0031418,L-ascorbic acid binding;GO:0050211,procollagen galactosyltransferase activity;GO:0033823,procollagen glucosyltransferase activity;GO:0008475,procollagen-lysine 5-dioxygenase activity	GO:0070831,basement membrane assembly;GO:0032870,cellular response to hormone stimulus;GO:0030199,collagen fibril organization;GO:0032963,collagen metabolic process;GO:0001886,endothelial cell morphogenesis;GO:0048730,epidermis morphogenesis;GO:0046947,hydroxylysine biosynthetic process;GO:0001701,in utero embryonic development;GO:0060425,lung morphogenesis;GO:0021915,neural tube development;GO:0017185,peptidyl-lysine hydroxylation;GO:0008104,protein localization;GO:0006493,protein O-linked glycosylation;GO:0042311,vasodilation	hsa:8985,path:hsa00310,Lysine degradation;hsa:8985,path:hsa00514,Other types of O-glycan biosynthesis
RTN3_HUMAN	O95197	RTN3	Reticulon-3	2.439315864	3.40776922	2.306661931	5.384540551	2.923542542	3.845601241	2.923542542	3.845601241	0.76023028878568	0.454379	0	1.31539089503696	0.454521	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005615,extracellular space;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0005886,plasma membrane;GO:0045202,synapse		GO:0006915,apoptotic process;GO:0071787,endoplasmic reticulum tubular network formation;GO:0071786,endoplasmic reticulum tubular network organization;GO:1902430,negative regulation of amyloid-beta formation;GO:0016192,vesicle-mediated transport;GO:0016032,viral process	hsa:10313,path:hsa05010,Alzheimer disease
VPS4A_HUMAN	Q9UN37	VPS4A	Vacuolar protein sorting-associated protein 4A	1.031708911	0.497223554	1.132504135	1.071625273	0.7644662325	1.102064704	0.7644662325	1.102064704	0.693667286254002	0.399503	0	1.44161332070348	0.399704	0	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005769,early endosome;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0090543,Flemming body;GO:0005770,late endosome;GO:0031902,late endosome membrane;GO:0005764,lysosome;GO:0030496,midbody;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0000922,spindle pole;GO:0005774,vacuolar membrane	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0008022,protein C-terminus binding;GO:0019904,protein domain specific binding;GO:0044877,protein-containing complex binding	GO:0009838,abscission;GO:0000916,actomyosin contractile ring contraction;GO:0051301,cell division;GO:0061640,cytoskeleton-dependent cytokinesis;GO:0016197,endosomal transport;GO:0034058,endosomal vesicle fusion;GO:1904896,ESCRT complex disassembly;GO:1904903,ESCRT III complex disassembly;GO:0032367,intracellular cholesterol transport;GO:0061738,late endosomal microautophagy;GO:0016236,macroautophagy;GO:0061952,midbody abscission;GO:0044878,mitotic cytokinesis checkpoint;GO:0007080,mitotic metaphase plate congression;GO:0007084,mitotic nuclear envelope reassembly;GO:0036258,multivesicular body assembly;GO:0032466,negative regulation of cytokinesis;GO:0006998,nuclear envelope organization;GO:0031468,nuclear envelope reassembly;GO:0006997,nucleus organization;GO:1903543,positive regulation of exosomal secretion;GO:1903774,positive regulation of viral budding via host ESCRT complex;GO:1903902,positive regulation of viral life cycle;GO:1902188,positive regulation of viral release from host cell;GO:0006622,protein targeting to lysosome;GO:0032880,regulation of protein localization;GO:1903076,regulation of protein localization to plasma membrane;GO:0043162,ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0090611,ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;GO:0007033,vacuole organization;GO:0006900,vesicle budding from membrane;GO:0072319,vesicle uncoating;GO:0016192,vesicle-mediated transport;GO:0039702,viral budding via host ESCRT complex;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019076,viral release from host cell	hsa:27183,path:hsa04144,Endocytosis;hsa:27183,path:hsa04217,Necroptosis
ITB2_HUMAN	P05107	ITGB2	Integrin beta-2	5.676179852	7.619035131	6.764852016	13.16271674	6.6476074915	9.963784378	6.6476074915	9.963784378	0.667176972052696	0.376708	0	1.4988526910983	0.376931	0	GO:0009986,cell surface;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:1903561,extracellular vesicle;GO:0101003,ficolin-1-rich granule membrane;GO:0005925,focal adhesion;GO:0034687,integrin alphaL-beta2 complex;GO:0034688,integrin alphaM-beta2 complex;GO:0034689,integrin alphaX-beta2 complex;GO:0008305,integrin complex;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0044853,plasma membrane raft;GO:0043235,receptor complex;GO:0035579,specific granule membrane;GO:0070821,tertiary granule membrane	GO:0001540,amyloid-beta binding;GO:0050839,cell adhesion molecule binding;GO:0001851,complement component C3b binding;GO:0031072,heat shock protein binding;GO:0030369,ICAM-3 receptor activity;GO:0005178,integrin binding;GO:0046872,metal ion binding;GO:0019901,protein kinase binding;GO:0038023,signaling receptor activity	GO:0007568,aging;GO:0097242,amyloid-beta clearance;GO:0006915,apoptotic process;GO:0007155,cell adhesion;GO:0033627,cell adhesion mediated by integrin;GO:0016477,cell migration;GO:0098609,cell-cell adhesion;GO:0098742,cell-cell adhesion via plasma-membrane adhesion molecules;GO:0007267,cell-cell signaling;GO:0007160,cell-matrix adhesion;GO:0045123,cellular extravasation;GO:0071404,cellular response to low-density lipoprotein particle stimulus;GO:0019221,cytokine-mediated signaling pathway;GO:0035987,endodermal cell differentiation;GO:0043542,endothelial cell migration;GO:0030198,extracellular matrix organization;GO:0034113,heterotypic cell-cell adhesion;GO:0006954,inflammatory response;GO:0007229,integrin-mediated signaling pathway;GO:0007159,leukocyte cell-cell adhesion;GO:0050900,leukocyte migration;GO:0002523,leukocyte migration involved in inflammatory response;GO:0001774,microglial cell activation;GO:0030101,natural killer cell activation;GO:0045963,negative regulation of dopamine metabolic process;GO:0030593,neutrophil chemotaxis;GO:0043312,neutrophil degranulation;GO:1990266,neutrophil migration;GO:0006911,phagocytosis, engulfment;GO:0045766,positive regulation of angiogenesis;GO:1904996,positive regulation of leukocyte adhesion to vascular endothelial cell;GO:1901216,positive regulation of neuron death;GO:0043315,positive regulation of neutrophil degranulation;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0045429,positive regulation of nitric oxide biosynthetic process;GO:2000363,positive regulation of prostaglandin-E synthase activity;GO:0090314,positive regulation of protein targeting to membrane;GO:0032930,positive regulation of superoxide anion generation;GO:0043113,receptor clustering;GO:0031623,receptor internalization;GO:0006898,receptor-mediated endocytosis;GO:0008360,regulation of cell shape;GO:0050776,regulation of immune response;GO:0050730,regulation of peptidyl-tyrosine phosphorylation;GO:0034142,toll-like receptor 4 signaling pathway;GO:0006909,phagocytosis	hsa:3689,path:hsa04015,Rap1 signaling pathway;hsa:3689,path:hsa04390,Hippo signaling pathway;hsa:3689,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3689,path:hsa04145,Phagosome;hsa:3689,path:hsa04810,Regulation of actin cytoskeleton;hsa:3689,path:hsa04610,Complement and coagulation cascades;hsa:3689,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3689,path:hsa04670,Leukocyte transendothelial migration;hsa:3689,path:hsa05323,Rheumatoid arthritis;hsa:3689,path:hsa05416,Viral myocarditis;hsa:3689,path:hsa05133,Pertussis;hsa:3689,path:hsa05134,Legionellosis;hsa:3689,path:hsa05150,Staphylococcus aureus infection;hsa:3689,path:hsa05152,Tuberculosis;hsa:3689,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3689,path:hsa05146,Amoebiasis;hsa:3689,path:hsa05144,Malaria;hsa:3689,path:hsa05140,Leishmaniasis
PDC6I_HUMAN	Q8WUM4	PDCD6IP	Programmed cell death 6-interacting protein	6.43028977	9.773523514	9.78398637	13.93648391	8.101906642	11.86023514	8.101906642	11.86023514	0.683115178271246	0.390483	0	1.46388198038681	0.390693	0	GO:0042641,actomyosin;GO:0005923,bicellular tight junction;GO:0005829,cytosol;GO:0070971,endoplasmic reticulum exit site;GO:0070062,extracellular exosome;GO:1903561,extracellular vesicle;GO:0090543,Flemming body;GO:0005925,focal adhesion;GO:0001772,immunological synapse;GO:0043231,intracellular membrane-bounded organelle;GO:0042470,melanosome;GO:0016020,membrane;GO:0005815,microtubule organizing center	GO:0048306,calcium-dependent protein binding;GO:0042803,protein homodimerization activity;GO:0031871,proteinase activated receptor binding	GO:0000915,actomyosin contractile ring assembly;GO:0006915,apoptotic process;GO:0070830,bicellular tight junction assembly;GO:0045199,maintenance of epithelial cell apical/basal polarity;GO:0061952,midbody abscission;GO:0000281,mitotic cytokinesis;GO:0036258,multivesicular body assembly;GO:1903543,positive regulation of exosomal secretion;GO:1903553,positive regulation of extracellular exosome assembly;GO:0051260,protein homooligomerization;GO:0015031,protein transport;GO:0010824,regulation of centrosome duplication;GO:1903551,regulation of extracellular exosome assembly;GO:0090559,regulation of membrane permeability;GO:0060544,regulation of necroptotic process;GO:0090611,ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;GO:0046755,viral budding;GO:0039702,viral budding via host ESCRT complex;GO:0019058,viral life cycle	hsa:10015,path:hsa04144,Endocytosis
ACTN4_HUMAN	O43707	ACTN4	Alpha-actinin-4	69.02255995	68.76295868	83.04143391	131.4333469	68.892759315	107.237390405	68.892759315	107.237390405	0.642432262243747	0.354985	0	1.55658434168206	0.355229	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0043005,neuron projection;GO:0016604,nuclear body;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0031093,platelet alpha granule lumen;GO:0032991,protein-containing complex;GO:0031143,pseudopodium;GO:1990904,ribonucleoprotein complex;GO:0001725,stress fiber	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0005509,calcium ion binding;GO:0031490,chromatin DNA binding;GO:0005178,integrin binding;GO:0044325,ion channel binding;GO:0035257,nuclear hormone receptor binding;GO:0030374,nuclear receptor coactivator activity;GO:0001882,nucleoside binding;GO:0042803,protein homodimerization activity;GO:0047485,protein N-terminus binding;GO:0042974,retinoic acid receptor binding;GO:0003723,RNA binding;GO:0000977,RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0003713,transcription coactivator activity	GO:1900025,negative regulation of substrate adhesion-dependent cell spreading;GO:0035357,peroxisome proliferator activated receptor signaling pathway;GO:0002576,platelet degranulation;GO:0030335,positive regulation of cell migration;GO:0051272,positive regulation of cellular component movement;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:0032417,positive regulation of sodium;GO:0015031,protein transport;GO:0042981,regulation of apoptotic process;GO:1903506,regulation of nucleic acid-templated transcription;GO:0001666,response to hypoxia;GO:0048384,retinoic acid receptor signaling pathway;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0030050,vesicle transport along actin filament	hsa:81,path:hsa04510,Focal adhesion;hsa:81,path:hsa04520,Adherens junction;hsa:81,path:hsa04530,Tight junction;hsa:81,path:hsa04810,Regulation of actin cytoskeleton;hsa:81,path:hsa04670,Leukocyte transendothelial migration;hsa:81,path:hsa05203,Viral carcinogenesis;hsa:81,path:hsa05322,Systemic lupus erythematosus;hsa:81,path:hsa05131,Shigellosis;hsa:81,path:hsa05146,Amoebiasis
EIF3B_HUMAN	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	3.420134548	2.800614554	4.831926374	4.155351388	3.110374551	4.493638881	3.110374551	4.493638881	0.692172787660193	0.398230	0	1.4447259670239	0.398432	0	GO:0005829,cytosol;GO:0016282,eukaryotic 43S preinitiation complex;GO:0033290,eukaryotic 48S preinitiation complex;GO:0005852,eukaryotic translation initiation factor 3 complex;GO:0071541,eukaryotic translation initiation factor 3 complex, eIF3m;GO:0070062,extracellular exosome;GO:0045202,synapse	GO:0060090,molecular adaptor activity;GO:0003723,RNA binding;GO:0003743,translation initiation factor activity;GO:0031369,translation initiation factor binding	GO:0001732,formation of cytoplasmic translation initiation complex;GO:0075522,IRES-dependent viral translational initiation;GO:0006446,regulation of translational initiation;GO:0006413,translational initiation;GO:0075525,viral translational termination-reinitiation	hsa:8662,path:hsa03013,RNA transport
ACL6A_HUMAN	O96019	ACTL6A	Actin-like protein 6A	1.169721338	1.256926996	1.640234578	1.1037949	1.213324167	1.372014739	1.213324167	1.372014739	0.884337560312463	0.474387	0	1.13078992104177	0.474280	0	GO:0000785,chromatin;GO:0031011,Ino80 complex;GO:0071564,npBAF complex;GO:0035267,NuA4 histone acetyltransferase complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0016514,SWI/SNF complex	GO:0003682,chromatin binding;GO:0003713,transcription coactivator activity	GO:0043044,ATP-dependent chromatin remodeling;GO:0001825,blastocyst formation;GO:0006338,chromatin remodeling;GO:0006310,DNA recombination;GO:0006281,DNA repair;GO:0043968,histone H2A acetylation;GO:0043967,histone H4 acetylation;GO:0007399,nervous system development;GO:0003407,neural retina development;GO:0016579,protein deubiquitination;GO:0040008,regulation of growth;GO:0006357,regulation of transcription by RNA polymerase II;GO:0007165,signal transduction;GO:0021510,spinal cord development	hsa:86,path:hsa04714,Thermogenesis;hsa:86,path:hsa05225,Hepatocellular carcinoma
MMAB_HUMAN	Q96EY8	MMAB	Corrinoid adenosyltransferase	0.442794233	1.283674731	0.11769257	2.55E-05	0.863234482	0.058859035	0.863234482	0.058859035	14.6661337889756	0.007520	1	0.0681842954924963	0.007406	-1	GO:0005759,mitochondrial matrix	GO:0005524,ATP binding;GO:0008817,cob(I)yrinic acid a,c-diamide adenosyltransferase activity;GO:0031419,cobalamin binding	GO:0009235,cobalamin metabolic process	hsa:326625,path:hsa00860,Porphyrin and chlorophyll metabolism
TTC1_HUMAN	Q99614	TTC1	Tetratricopeptide repeat protein 1	0.338935027	0.658457385	0.761345092	0.960283665	0.498696206	0.8608143785	0.498696206	0.8608143785	0.579330711075013	0.298092	0	1.72612979233293	0.298382	0	GO:0005829,cytosol;GO:0005778,peroxisomal membrane	GO:0051082,unfolded protein binding	GO:0006457,protein folding	
ACADM_HUMAN	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	1.891864191	1.566829565	4.483666864	1.621701883	1.729346878	3.0526843735	1.729346878	3.0526843735	0.566500386680084	0.286336	0	1.76522386129407	0.286634	0	GO:0030424,axon;GO:0005759,mitochondrial matrix;GO:0031966,mitochondrial membrane;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0003995,acyl-CoA dehydrogenase activity;GO:0050660,flavin adenine dinucleotide binding;GO:0042802,identical protein binding;GO:0070991,medium-chain-acyl-CoA dehydrogenase activity;GO:0016627,oxidoreductase activity, acting on the CH-CH group of donors	GO:0045329,carnitine biosynthetic process;GO:0019254,carnitine metabolic process, CoA-linked;GO:0006635,fatty acid beta-oxidation;GO:0033539,fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0051793,medium-chain fatty acid catabolic process;GO:0051791,medium-chain fatty acid metabolic process;GO:0019222,regulation of metabolic process;GO:0055007,cardiac muscle cell differentiation;GO:0005978,glycogen biosynthetic process;GO:0001889,liver development;GO:0009791,post-embryonic development;GO:0006111,regulation of gluconeogenesis;GO:0009409,response to cold;GO:0042594,response to starvation	hsa:34,path:hsa00071,Fatty acid degradation;hsa:34,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:34,path:hsa03320,PPAR signaling pathway
LC7L3_HUMAN	O95232	LUC7L3	Luc7-like protein 3	0.294125421	0.229439377	0.501209438	0.120471782	0.261782399	0.31084061	0.261782399	0.31084061	0.842175670032304	0.490796	0	1.18740072360633	0.490725	0	GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005685,U1 snRNP;GO:0071004,U2-type prespliceosome	GO:0003677,DNA binding;GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0006376,mRNA splice site selection;GO:0008380,RNA splicing	
PRPS1_HUMAN	P60891	PRPS1	Ribose-phosphate pyrophosphokinase 1	4.76551242	2.680869075	5.752139642	6.518957034	3.7231907475	6.135548338	3.7231907475	6.135548338	0.606822820454487	0.323102	0	1.64792747782794	0.323373	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0002189,ribose phosphate diphosphokinase complex;GO:0016021,integral component of membrane	GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0016301,kinase activity;GO:0000287,magnesium ion binding;GO:0042803,protein homodimerization activity;GO:0004749,ribose phosphate diphosphokinase activity	GO:0006015,5-phosphoribose 1-diphosphate biosynthetic process;GO:0046101,hypoxanthine biosynthetic process;GO:0007399,nervous system development;GO:0009116,nucleoside metabolic process;GO:0006144,purine nucleobase metabolic process;GO:0006164,purine nucleotide biosynthetic process;GO:0006221,pyrimidine nucleotide biosynthetic process;GO:0009156,ribonucleoside monophosphate biosynthetic process;GO:0034418,urate biosynthetic process;GO:0009165,nucleotide biosynthetic process	hsa:5631,path:hsa00030,Pentose phosphate pathway;hsa:5631,path:hsa00230,Purine metabolism
TRFE_HUMAN	P02787	TF	Serotransferrin	50.92667651	49.7505269	74.12775072	341.8745942	50.338601705	208.00117246	50.338601705	208.00117246	0.242011144022183	0.031171	-1	4.13204112579352	0.031338	1	GO:0016324,apical plasma membrane;GO:0045178,basal part of cell;GO:0009925,basal plasma membrane;GO:0072562,blood microparticle;GO:0009986,cell surface;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0005905,clathrin-coated pit;GO:0031410,cytoplasmic vesicle;GO:0005769,early endosome;GO:0030139,endocytic vesicle;GO:0005788,endoplasmic reticulum lumen;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0031232,extrinsic component of external side of plasma membrane;GO:1990712,HFE-transferrin receptor complex;GO:0005770,late endosome;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0055037,recycling endosome;GO:0034774,secretory granule lumen;GO:0031982,vesicle	GO:0008199,ferric iron binding;GO:0008198,ferrous iron binding;GO:0034986,iron chaperone activity;GO:1990459,transferrin receptor binding	GO:0007015,actin filament organization;GO:0007257,activation of JUN kinase activity;GO:0019731,antibacterial humoral response;GO:0006879,cellular iron ion homeostasis;GO:0044267,cellular protein metabolic process;GO:0071281,cellular response to iron ion;GO:0070371,ERK1 and ERK2 cascade;GO:0055072,iron ion homeostasis;GO:0006826,iron ion transport;GO:0061024,membrane organization;GO:0030316,osteoclast differentiation;GO:0002576,platelet degranulation;GO:0045780,positive regulation of bone resorption;GO:2000147,positive regulation of cell motility;GO:0048260,positive regulation of receptor-mediated endocytosis;GO:0045893,positive regulation of transcription, DNA-templated;GO:0043687,post-translational protein modification;GO:0034756,regulation of iron ion transport;GO:0031647,regulation of protein stability;GO:0001895,retina homeostasis;GO:0060395,SMAD protein signal transduction;GO:0033572,transferrin transport	hsa:7018,path:hsa04066,HIF-1 signaling pathway;hsa:7018,path:hsa04216,Ferroptosis;hsa:7018,path:hsa04978,Mineral absorption
SBSN_HUMAN	Q6UWP8	SBSN	Suprabasin	0.256442951	0.008618353	0.069234165	0.011247432	0.132530652	0.0402407985	0.132530652	0.0402407985	3.29343991521441	0.120501	0	0.303633898216995	0.119952	0	GO:0070062,extracellular exosome			
QSOX2_HUMAN	Q6ZRP7	QSOX2	Sulfhydryl oxidase 2	0.052730445	0.007979582	0.105326146	0.562508984	0.0303550135	0.333917565	0.0303550135	0.333917565	0.0909057105157077	0.000389	-1	11.0004090428094	0.000395	1	GO:0005615,extracellular space;GO:0005794,Golgi apparatus;GO:0030173,integral component of Golgi membrane;GO:0031965,nuclear membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0016971,flavin-linked sulfhydryl oxidase activity;GO:0003756,protein disulfide isomerase activity	GO:0006457,protein folding	
STXB2_HUMAN	Q15833	STXBP2	Syntaxin-binding protein 2	1.754833058	2.356524138	2.247642345	2.947572066	2.055678598	2.5976072055	2.055678598	2.5976072055	0.791373920447804	0.478767	0	1.26362516398587	0.478882	0	GO:0042582,azurophil granule;GO:0044194,cytolytic granule;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005886,plasma membrane;GO:0098793,presynapse;GO:0030141,secretory granule;GO:0042581,specific granule;GO:0070820,tertiary granule;GO:0016021,integral component of membrane	GO:0019905,syntaxin binding;GO:0017075,syntaxin-1 binding;GO:0030348,syntaxin-3 binding	GO:0006886,intracellular protein transport;GO:0001909,leukocyte mediated cytotoxicity;GO:0007269,neurotransmitter secretion;GO:0043312,neutrophil degranulation;GO:0002576,platelet degranulation;GO:0043304,regulation of mast cell degranulation;GO:0006904,vesicle docking involved in exocytosis;GO:0016192,vesicle-mediated transport;GO:0015031,protein transport	
TB182_HUMAN	Q9C0C2	TNKS1BP1	182 kDa tankyrase-1-binding protein	0.832036852	0.832427687	0.80462464	0.437449671	0.8322322695	0.6210371555	0.8322322695	0.6210371555	1.34006840352405	0.339228	0	0.746230563581866	0.338843	0	GO:0015629,actin cytoskeleton;GO:0005912,adherens junction;GO:0030014,CCR4-NOT complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0000792,heterochromatin;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0071532,ankyrin repeat binding;GO:0045296,cadherin binding;GO:0019899,enzyme binding;GO:0044877,protein-containing complex binding	GO:0071479,cellular response to ionizing radiation;GO:0006977,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0006302,double-strand break repair;GO:0000289,nuclear-transcribed mRNA poly(A) tail shortening;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0010800,positive regulation of peptidyl-threonine phosphorylation;GO:0031954,positive regulation of protein autophosphorylation;GO:0007004,telomere maintenance via telomerase	
FILA_HUMAN	P20930	FLG	Filaggrin	0.471056089	0.067693467	0.223185995	0.282200388	0.269374778	0.2526931915	0.269374778	0.2526931915	1.06601517991433	0.412262	0	0.938072945715801	0.412020	0	GO:0062023,collagen-containing extracellular matrix;GO:0001533,cornified envelope;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0005882,intermediate filament;GO:0036457,keratohyalin granule;GO:0005634,nucleus	GO:0005509,calcium ion binding;GO:0030280,structural constituent of skin epidermis;GO:0005198,structural molecule activity;GO:0046914,transition metal ion binding	GO:0070268,cornification;GO:0061436,establishment of skin barrier;GO:0030216,keratinocyte differentiation;GO:0007275,multicellular organism development;GO:0018149,peptide cross-linking	
IKKB_HUMAN	O14920	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta	0.208681706	0.298971041	0.390268791	0.672336982	0.2538263735	0.5313028865	0.2538263735	0.5313028865	0.477743260858418	0.204818	0	2.09317447660733	0.205152	0	GO:0035631,CD40 receptor complex;GO:0005737,cytoplasm;GO:0009898,cytoplasmic side of plasma membrane;GO:0005829,cytosol;GO:0008385,IkappaB kinase complex;GO:0045121,membrane raft;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0008384,IkappaB kinase activity;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0004672,protein kinase activity;GO:0019901,protein kinase binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0097110,scaffold protein binding;GO:1990459,transferrin receptor binding	GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0071356,cellular response to tumor necrosis factor;GO:0030866,cortical actin cytoskeleton organization;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0007249,I-kappaB kinase/NF-kappaB signaling;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0070498,interleukin-1-mediated signaling pathway;GO:0002756,MyD88-independent toll-like receptor signaling pathway;GO:0043066,negative regulation of apoptotic process;GO:1903347,negative regulation of bicellular tight junction assembly;GO:0035509,negative regulation of myosin-light-chain-phosphatase activity;GO:0018105,peptidyl-serine phosphorylation;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0072659,protein localization to plasma membrane;GO:0006468,protein phosphorylation;GO:1903140,regulation of establishment of endothelial barrier;GO:0042325,regulation of phosphorylation;GO:0010803,regulation of tumor necrosis factor-mediated signaling pathway;GO:0009615,response to virus;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0051403,stress-activated MAPK cascade;GO:0050852,T cell receptor signaling pathway;GO:0035666,TRIF-dependent toll-like receptor signaling pathway;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process	hsa:3551,path:hsa04014,Ras signaling pathway;hsa:3551,path:hsa04010,MAPK signaling pathway;hsa:3551,path:hsa04064,NF-kappa B signaling pathway;hsa:3551,path:hsa04668,TNF signaling pathway;hsa:3551,path:hsa04068,FoxO signaling pathway;hsa:3551,path:hsa04151,PI3K-Akt signaling pathway;hsa:3551,path:hsa04150,mTOR signaling pathway;hsa:3551,path:hsa04210,Apoptosis;hsa:3551,path:hsa04620,Toll-like receptor signaling pathway;hsa:3551,path:hsa04621,NOD-like receptor signaling pathway;hsa:3551,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:3551,path:hsa04623,Cytosolic DNA-sensing pathway;hsa:3551,path:hsa04625,C-type lectin receptor signaling pathway;hsa:3551,path:hsa04660,T cell receptor signaling pathway;hsa:3551,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3551,path:hsa04659,Th17 cell differentiation;hsa:3551,path:hsa04657,IL-17 signaling pathway;hsa:3551,path:hsa04662,B cell receptor signaling pathway;hsa:3551,path:hsa04062,Chemokine signaling pathway;hsa:3551,path:hsa04910,Insulin signaling pathway;hsa:3551,path:hsa04920,Adipocytokine signaling pathway;hsa:3551,path:hsa04722,Neurotrophin signaling pathway;hsa:3551,path:hsa04380,Osteoclast differentiation;hsa:3551,path:hsa05200,Pathways in cancer;hsa:3551,path:hsa05206,MicroRNAs in cancer;hsa:3551,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:3551,path:hsa05212,Pancreatic cancer;hsa:3551,path:hsa05221,Acute myeloid leukemia;hsa:3551,path:hsa05220,Chronic myeloid leukemia;hsa:3551,path:hsa05215,Prostate cancer;hsa:3551,path:hsa05222,Small cell lung cancer;hsa:3551,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:3551,path:hsa04930,Type II diabetes mellitus;hsa:3551,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:3551,path:hsa04931,Insulin resistance;hsa:3551,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:3551,path:hsa05130,Pathogenic Escherichia coli infection;hsa:3551,path:hsa05132,Salmonella infection;hsa:3551,path:hsa05131,Shigellosis;hsa:3551,path:hsa05135,Yersinia infection;hsa:3551,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3551,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3551,path:hsa05162,Measles;hsa:3551,path:hsa05164,Influenza A;hsa:3551,path:hsa05161,Hepatitis B;hsa:3551,path:hsa05160,Hepatitis C;hsa:3551,path:hsa05168,Herpes simplex virus 1 infection;hsa:3551,path:hsa05163,Human cytomegalovirus infection;hsa:3551,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3551,path:hsa05169,Epstein-Barr virus infection;hsa:3551,path:hsa05165,Human papillomavirus infection;hsa:3551,path:hsa05145,Toxoplasmosis;hsa:3551,path:hsa05142,Chagas disease (American trypanosomiasis);hsa:3551,path:hsa01523,Antifolate resistance
RS14_HUMAN	P62263	RPS14	40S ribosomal protein S14	11.21891972	5.26737857	1.719407261	1.369929782	8.243149145	1.5446685215	8.243149145	1.5446685215	5.33651656019715	0.057135	0	0.187388156434964	0.056718	0	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0014069,postsynaptic density;GO:0005840,ribosome	GO:0048027,mRNA 5'-UTR binding;GO:0003723,RNA binding;GO:0070181,small ribosomal subunit rRNA binding;GO:0003735,structural constituent of ribosome;GO:0045182,translation regulator activity	GO:0002181,cytoplasmic translation;GO:0030218,erythrocyte differentiation;GO:0030490,maturation of SSU-rRNA;GO:0000462,maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000028,ribosomal small subunit assembly;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6208,path:hsa03010,Ribosome
DDX50_HUMAN	Q9BQ39	DDX50	ATP-dependent RNA helicase DDX50	0.037009077	0.026421421	0.077885631	0.029358119	0.031715249	0.053621875	0.031715249	0.053621875	0.591461022204091	0.309162	0	1.69072848836848	0.309444	0	GO:0016020,membrane;GO:0005730,nucleolus;GO:0005886,plasma membrane	GO:0005524,ATP binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity		
ACTS_HUMAN	P68133	ACTA1	Actin, alpha skeletal muscle	2.55E-05	2.55E-05	2.55E-05	2.55E-05	2.55e-005	2.55e-005	2.55e-005	2.55e-005	1	0.433351	0	1	0.433154	0	GO:0015629,actin cytoskeleton;GO:0005884,actin filament;GO:0072562,blood microparticle;GO:0044297,cell body;GO:0005829,cytosol;GO:0005869,dynactin complex;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0030175,filopodium;GO:0030027,lamellipodium;GO:0030017,sarcomere;GO:0001725,stress fiber;GO:0005865,striated muscle thin filament	GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0017022,myosin binding;GO:0005200,structural constituent of cytoskeleton	GO:0071417,cellular response to organonitrogen compound;GO:0090131,mesenchyme migration;GO:0006936,muscle contraction;GO:0030049,muscle filament sliding;GO:0010628,positive regulation of gene expression;GO:0009991,response to extracellular stimulus;GO:0010226,response to lithium ion;GO:0009612,response to mechanical stimulus;GO:0048545,response to steroid hormone;GO:0043503,skeletal muscle fiber adaptation;GO:0048741,skeletal muscle fiber development;GO:0030240,skeletal muscle thin filament assembly	
U2AF2_HUMAN	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	0.982216469	0.579600189	1.734652205	0.503606278	0.780908329	1.1191292415	0.780908329	1.1191292415	0.697782079175526	0.402998	0	1.43311218479781	0.403195	0	GO:0000243,commitment complex;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0071004,U2-type prespliceosome;GO:0089701,U2AF complex	GO:0070742,C2H2 zinc finger domain binding;GO:0019899,enzyme binding;GO:0008187,poly-pyrimidine tract binding;GO:0030628,pre-mRNA 3'-splice site binding;GO:0003723,RNA binding	GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0048025,negative regulation of mRNA splicing, via spliceosome;GO:0031397,negative regulation of protein ubiquitination;GO:0033120,positive regulation of RNA splicing;GO:0006405,RNA export from nucleus;GO:0008380,RNA splicing	hsa:11338,path:hsa03040,Spliceosome
SEPT7_HUMAN	Q16181	SEPTIN7	Septin-7	4.042120396	3.30015245	5.048078374	7.52775799	3.671136423	6.287918182	3.671136423	6.287918182	0.583839725127009	0.302213	0	1.71279883324565	0.302500	0	GO:0005930,axoneme;GO:0032153,cell division site;GO:0032154,cleavage furrow;GO:0000777,condensed chromosome kinetochore;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0015630,microtubule cytoskeleton;GO:0030496,midbody;GO:0097730,non-motile cilium;GO:0005634,nucleus;GO:0031105,septin complex;GO:0005940,septin ring;GO:0097227,sperm annulus;GO:0005819,spindle;GO:0001725,stress fiber;GO:0031514,motile cilium;GO:0005856,cytoskeleton	GO:0045296,cadherin binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0060090,molecular adaptor activity;GO:0005198,structural molecule activity	GO:0030154,cell differentiation;GO:0034613,cellular protein localization;GO:0060271,cilium assembly;GO:0061640,cytoskeleton-dependent cytokinesis;GO:1902857,positive regulation of non-motile cilium assembly;GO:0016476,regulation of embryonic cell shape;GO:0007283,spermatogenesis	hsa:989,path:hsa05131,Shigellosis
TCPZ_HUMAN	P40227	CCT6A	T-complex protein 1 subunit zeta	17.55900628	8.1430789	15.55254153	22.78846399	12.85104259	19.17050276	12.85104259	19.17050276	0.670355011075359	0.379469	0	1.49174688557312	0.379689	0	GO:0005832,chaperonin-containing T-complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005874,microtubule	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0044183,protein folding chaperone;GO:0003723,RNA binding;GO:0051082,unfolded protein binding;GO:0071987,WD40-repeat domain binding	GO:1904851,positive regulation of establishment of protein localization to telomere;GO:1904871,positive regulation of protein localization to Cajal body;GO:1904874,positive regulation of telomerase RNA localization to Cajal body;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:0006457,protein folding;GO:0050821,protein stabilization	
FINC_HUMAN	P02751	FN1	Fibronectin	162.8068936	135.43975	72.50855871	182.9156681	149.1233218	127.712113405	149.1233218	127.712113405	1.16765213435237	0.382665	0	0.856419451119013	0.382363	0	GO:0016324,apical plasma membrane;GO:0005604,basement membrane;GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005577,fibrinogen complex;GO:0031093,platelet alpha granule lumen	GO:0051087,chaperone binding;GO:0005518,collagen binding;GO:0097718,disordered domain specific binding;GO:0019899,enzyme binding;GO:0005201,extracellular matrix structural constituent;GO:0008201,heparin binding;GO:0042802,identical protein binding;GO:0005178,integrin binding;GO:0016504,peptidase activator activity;GO:0002020,protease binding;GO:0008022,protein C-terminus binding;GO:0043394,proteoglycan binding;GO:0005102,signaling receptor binding	GO:0006953,acute-phase response;GO:0001525,angiogenesis;GO:0051702,biological process involved in interaction with symbiont;GO:0072378,blood coagulation, fibrin clot formation;GO:0007161,calcium-independent cell-matrix adhesion;GO:0007155,cell adhesion;GO:0007160,cell-matrix adhesion;GO:0007044,cell-substrate junction assembly;GO:0044267,cellular protein metabolic process;GO:0019221,cytokine-mediated signaling pathway;GO:0035987,endodermal cell differentiation;GO:0030198,extracellular matrix organization;GO:0007507,heart development;GO:0033622,integrin activation;GO:0007229,integrin-mediated signaling pathway;GO:0050900,leukocyte migration;GO:0071635,negative regulation of transforming growth factor beta production;GO:0007399,nervous system development;GO:1901166,neural crest cell migration involved in autonomic nervous system development;GO:0018149,peptide cross-linking;GO:0070527,platelet aggregation;GO:0002576,platelet degranulation;GO:0045773,positive regulation of axon extension;GO:0008284,positive regulation of cell population proliferation;GO:0048146,positive regulation of fibroblast proliferation;GO:0010628,positive regulation of gene expression;GO:0014068,positive regulation of phosphatidylinositol 3-kinase signaling;GO:1904237,positive regulation of substrate-dependent cell migration, cell attachment to substrate;GO:0043687,post-translational protein modification;GO:0008360,regulation of cell shape;GO:0070372,regulation of ERK1 and ERK2 cascade;GO:0001932,regulation of protein phosphorylation;GO:0009611,response to wounding;GO:0034446,substrate adhesion-dependent cell spreading	hsa:2335,path:hsa04151,PI3K-Akt signaling pathway;hsa:2335,path:hsa04512,ECM-receptor interaction;hsa:2335,path:hsa04510,Focal adhesion;hsa:2335,path:hsa04810,Regulation of actin cytoskeleton;hsa:2335,path:hsa05200,Pathways in cancer;hsa:2335,path:hsa05205,Proteoglycans in cancer;hsa:2335,path:hsa05222,Small cell lung cancer;hsa:2335,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:2335,path:hsa05135,Yersinia infection;hsa:2335,path:hsa05100,Bacterial invasion of epithelial cells;hsa:2335,path:hsa05165,Human papillomavirus infection;hsa:2335,path:hsa05146,Amoebiasis
MPC2_HUMAN	O95563	MPC2	Mitochondrial pyruvate carrier 2	0.350297017	0.939656817	0.346858973	0.157094524	0.644976917	0.2519767485	0.644976917	0.2519767485	2.55966838543438	0.168518	0	0.390675606922534	0.167948	0	GO:0031305,integral component of mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane	GO:0042802,identical protein binding;GO:0050833,pyruvate transmembrane transporter activity	GO:0061732,mitochondrial acetyl-CoA biosynthetic process from pyruvate;GO:0006850,mitochondrial pyruvate transmembrane transport;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus	
SFXN1_HUMAN	Q9H9B4	SFXN1	Sideroflexin-1	2.725024583	1.185101059	1.809788983	0.621892735	1.955062821	1.215840859	1.955062821	1.215840859	1.60799236719844	0.284951	0	0.621893499247306	0.284477	0	GO:0031305,integral component of mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0016021,integral component of membrane	GO:0042945,D-serine transmembrane transporter activity;GO:0015194,L-serine transmembrane transporter activity;GO:0022889,serine transmembrane transporter activity;GO:0022857,transmembrane transporter activity;GO:0015075,ion transmembrane transporter activity	GO:0042942,D-serine transport;GO:0015825,L-serine transport;GO:1990542,mitochondrial transmembrane transport;GO:0006730,one-carbon metabolic process;GO:0140300,serine import into mitochondrion;GO:0006865,amino acid transport	
RBM39_HUMAN	Q14498	RBM39	RNA-binding protein 39	1.168133259	0.528050301	1.041549208	0.862627367	0.84809178	0.9520882875	0.84809178	0.9520882875	0.890770100981838	0.471955	0	1.12262411917257	0.471843	0	GO:0034451,centriolar satellite;GO:0015630,microtubule cytoskeleton;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0032991,protein-containing complex;GO:0005634,nucleus	GO:0003723,RNA binding;GO:0050733,RS domain binding;GO:0003676,nucleic acid binding	GO:0006397,mRNA processing;GO:0048024,regulation of mRNA splicing, via spliceosome;GO:0006396,RNA processing;GO:0008380,RNA splicing	
UBIP1_HUMAN	Q9NZI7	UBP1	Upstream-binding protein 1	2.55E-05	0.0179526	2.55E-05	0.045354786	0.00898905	0.022690143	0.00898905	0.022690143	0.396165418613713	0.133353	0	2.5241981076977	0.133677	0	GO:0000785,chromatin;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0001228,DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:1990837,sequence-specific double-stranded DNA binding	GO:0001525,angiogenesis;GO:0032897,negative regulation of viral transcription;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0006357,regulation of transcription by RNA polymerase II	
RS25_HUMAN	P62851	RPS25	40S ribosomal protein S25	5.888922609	18.79260163	0.690357923	0.315379092	12.3407621195	0.5028685075	12.3407621195	0.5028685075	24.5407336817568	0.002083	1	0.0407485779752129	0.002041	-1	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0070062,extracellular exosome;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0014069,postsynaptic density;GO:0005840,ribosome;GO:0015935,small ribosomal subunit	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0042274,ribosomal small subunit biogenesis;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6230,path:hsa03010,Ribosome
MRP1_HUMAN	P33527	ABCC1	Multidrug resistance-associated protein 1	0.210032482	0.199792633	0.449743716	1.698949006	0.2049125575	1.074346361	0.2049125575	1.074346361	0.190732304718999	0.012949	-1	5.24295033016705	0.013042	1	GO:0016324,apical plasma membrane;GO:0009925,basal plasma membrane;GO:0016323,basolateral plasma membrane;GO:0070062,extracellular exosome;GO:0005887,integral component of plasma membrane;GO:0016328,lateral plasma membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0015431,ABC-type glutathione S-conjugate transporter activity;GO:0140359,ABC-type transporter activity;GO:0008559,ABC-type xenobiotic transporter activity;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0034040,ATPase-coupled lipid transmembrane transporter activity;GO:0042626,ATPase-coupled transmembrane transporter activity;GO:0046943,carboxylic acid transmembrane transporter activity;GO:0015562,efflux transmembrane transporter activity;GO:0034634,glutathione transmembrane transporter activity;GO:0042910,xenobiotic transmembrane transporter activity	GO:1905039,carboxylic acid transmembrane transport;GO:0060326,cell chemotaxis;GO:1904646,cellular response to amyloid-beta;GO:0009235,cobalamin metabolic process;GO:0140115,export across plasma membrane;GO:0034775,glutathione transmembrane transport;GO:0042167,heme catabolic process;GO:0006691,leukotriene metabolic process;GO:0071716,leukotriene transport;GO:0045332,phospholipid translocation;GO:0050729,positive regulation of inflammatory response;GO:0042493,response to drug;GO:0099039,sphingolipid translocation;GO:0070633,transepithelial transport;GO:0055085,transmembrane transport;GO:0150104,transport across blood-brain barrier;GO:0042908,xenobiotic transport;GO:1990962,xenobiotic transport across blood-brain barrier	hsa:4363,path:hsa02010,ABC transporters;hsa:4363,path:hsa04071,Sphingolipid signaling pathway;hsa:4363,path:hsa04977,Vitamin digestion and absorption;hsa:4363,path:hsa05206,MicroRNAs in cancer;hsa:4363,path:hsa01523,Antifolate resistance
CLPX_HUMAN	O76031	CLPX	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial	0.134525853	0.075941632	0.190512453	0.1136814	0.1052337425	0.1520969265	0.1052337425	0.1520969265	0.691886055304346	0.397986	0	1.4453246923153	0.398188	0	GO:0005829,cytosol;GO:0009368,endopeptidase Clp complex;GO:0009841,mitochondrial endopeptidase Clp complex;GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0042645,mitochondrial nucleoid;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0016504,peptidase activator activity;GO:0046983,protein dimerization activity;GO:0051082,unfolded protein binding;GO:0008270,zinc ion binding	GO:0046034,ATP metabolic process;GO:0030163,protein catabolic process;GO:0006457,protein folding;GO:0006508,proteolysis;GO:0051603,proteolysis involved in cellular protein catabolic process	
GNA1_HUMAN	Q96EK6	GNPNAT1	Glucosamine 6-phosphate N-acetyltransferase	0.282753132	0.113874902	0.013858301	0.004593119	0.198314017	0.00922571	0.198314017	0.00922571	21.4957999980489	0.002947	1	0.0465207156789124	0.002891	-1	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0010008,endosome membrane;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane	GO:0004343,glucosamine 6-phosphate N-acetyltransferase activity;GO:0042802,identical protein binding;GO:0048029,monosaccharide binding;GO:0008080,N-acetyltransferase activity	GO:0006041,glucosamine metabolic process;GO:0001889,liver development;GO:0006044,N-acetylglucosamine metabolic process;GO:0006048,UDP-N-acetylglucosamine biosynthetic process	hsa:64841,path:hsa00520,Amino sugar and nucleotide sugar metabolism
EMC1_HUMAN	Q8N766	EMC1	ER membrane protein complex subunit 1	1.360821288	1.171489556	1.619086186	1.220344148	1.266155422	1.419715167	1.266155422	1.419715167	0.891837638584585	0.471554	0	1.12128032809546	0.471440	0	GO:0072546,EMC complex;GO:0005789,endoplasmic reticulum membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0032991,protein-containing complex		GO:0045050,protein insertion into ER membrane by stop-transfer membrane-anchor sequence;GO:0071816,tail-anchored membrane protein insertion into ER membrane	
PFKAM_HUMAN	P08237	PFKM	ATP-dependent 6-phosphofructokinase, muscle type	1.572899823	1.437196322	2.439790989	3.784389521	1.5050480725	3.112090255	1.5050480725	3.112090255	0.483613246782266	0.210158	0	2.06776800812122	0.210491	0	GO:0005945,6-phosphofructokinase complex;GO:0016324,apical plasma membrane;GO:0005829,cytosol;GO:0016020,membrane;GO:0005634,nucleus;GO:0097228,sperm principal piece;GO:0005737,cytoplasm	GO:0003872,6-phosphofructokinase activity;GO:0016208,AMP binding;GO:0005524,ATP binding;GO:0070061,fructose binding;GO:0070095,fructose-6-phosphate binding;GO:0042802,identical protein binding;GO:0019900,kinase binding;GO:0046872,metal ion binding;GO:0048029,monosaccharide binding;GO:0008022,protein C-terminus binding	GO:0061621,canonical glycolysis;GO:0030388,fructose 1,6-bisphosphate metabolic process;GO:0006002,fructose 6-phosphate metabolic process;GO:0006096,glycolytic process;GO:0061615,glycolytic process through fructose-6-phosphate;GO:0046716,muscle cell cellular homeostasis;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0042593,glucose homeostasis;GO:0005980,glycogen catabolic process;GO:0093001,glycolysis from storage polysaccharide through glucose-1-phosphate;GO:0032024,positive regulation of insulin secretion	hsa:5213,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:5213,path:hsa00030,Pentose phosphate pathway;hsa:5213,path:hsa00051,Fructose and mannose metabolism;hsa:5213,path:hsa00052,Galactose metabolism;hsa:5213,path:hsa03018,RNA degradation;hsa:5213,path:hsa04066,HIF-1 signaling pathway;hsa:5213,path:hsa04152,AMPK signaling pathway;hsa:5213,path:hsa04922,Glucagon signaling pathway;hsa:5213,path:hsa05230,Central carbon metabolism in cancer
NDUAD_HUMAN	Q9P0J0	NDUFA13	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	1.708197567	2.855231884	0.237443063	0.082206186	2.2817147255	0.1598246245	2.2817147255	0.1598246245	14.2763653137818	0.008005	1	0.0700458399614251	0.007885	-1	GO:0005737,cytoplasm;GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0031966,mitochondrial membrane;GO:0005746,mitochondrial respirasome;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0070469,respirasome	GO:0005524,ATP binding;GO:0008137,NADH dehydrogenase (ubiquinone) activity;GO:0003954,NADH dehydrogenase activity	GO:0097190,apoptotic signaling pathway;GO:0035458,cellular response to interferon-beta;GO:0071300,cellular response to retinoic acid;GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0030308,negative regulation of cell growth;GO:2001243,negative regulation of intrinsic apoptotic signaling pathway;GO:0045892,negative regulation of transcription, DNA-templated;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0010952,positive regulation of peptidase activity;GO:0045732,positive regulation of protein catabolic process;GO:0045039,protein insertion into mitochondrial inner membrane;GO:0072593,reactive oxygen species metabolic process;GO:0016032,viral process;GO:0097191,extrinsic apoptotic signaling pathway	hsa:51079,path:hsa00190,Oxidative phosphorylation;hsa:51079,path:hsa04723,Retrograde endocannabinoid signaling;hsa:51079,path:hsa04714,Thermogenesis;hsa:51079,path:hsa05010,Alzheimer disease;hsa:51079,path:hsa05012,Parkinson disease;hsa:51079,path:hsa05016,Huntington disease;hsa:51079,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
UBA1_HUMAN	P22314	UBA1	Ubiquitin-like modifier-activating enzyme 1	18.82952542	23.75848277	26.55831818	23.3605459	21.294004095	24.95943204	21.294004095	24.95943204	0.853144577203288	0.486447	0	1.17213427444868	0.486366	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0003723,RNA binding;GO:0004839,ubiquitin activating enzyme activity;GO:0008641,ubiquitin-like modifier activating enzyme activity	GO:0006974,cellular response to DNA damage stimulus;GO:0032446,protein modification by small protein conjugation;GO:0016567,protein ubiquitination;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:7317,path:hsa04120,Ubiquitin mediated proteolysis;hsa:7317,path:hsa05012,Parkinson disease
NDUS5_HUMAN	O43920	NDUFS5	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	1.49554191	0.259575752	0.794784015	0.515927748	0.877558831	0.6553558815	0.877558831	0.6553558815	1.33905692429496	0.339461	0	0.746794241422203	0.339076	0	GO:0005743,mitochondrial inner membrane;GO:0005758,mitochondrial intermembrane space;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion	GO:0008137,NADH dehydrogenase (ubiquinone) activity	GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly	hsa:4725,path:hsa00190,Oxidative phosphorylation;hsa:4725,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4725,path:hsa04714,Thermogenesis;hsa:4725,path:hsa05010,Alzheimer disease;hsa:4725,path:hsa05012,Parkinson disease;hsa:4725,path:hsa05016,Huntington disease;hsa:4725,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
DPP4_HUMAN	P27487	DPP4	Dipeptidyl peptidase 4	0.081759635	2.344929719	0.674199529	0.619333359	1.213344677	0.646766444	1.213344677	0.646766444	1.87601674183332	0.242546	0	0.533044283508239	0.242019	0	GO:0016324,apical plasma membrane;GO:0009986,cell surface;GO:0030139,endocytic vesicle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005925,focal adhesion;GO:0016021,integral component of membrane;GO:0046581,intercellular canaliculus;GO:0030027,lamellipodium;GO:0031258,lamellipodium membrane;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0045121,membrane raft;GO:0005886,plasma membrane	GO:0004177,aminopeptidase activity;GO:0045499,chemorepellent activity;GO:0008239,dipeptidyl-peptidase activity;GO:0042802,identical protein binding;GO:0002020,protease binding;GO:0042803,protein homodimerization activity;GO:0004252,serine-type endopeptidase activity;GO:0008236,serine-type peptidase activity;GO:0005102,signaling receptor binding;GO:0001618,virus receptor activity	GO:0001662,behavioral fear response;GO:0007155,cell adhesion;GO:0043542,endothelial cell migration;GO:0035641,locomotory exploration behavior;GO:0010716,negative regulation of extracellular matrix disassembly;GO:0090024,negative regulation of neutrophil chemotaxis;GO:0008284,positive regulation of cell population proliferation;GO:0006508,proteolysis;GO:0036343,psychomotor behavior;GO:0033632,regulation of cell-cell adhesion mediated by integrin;GO:0050796,regulation of insulin secretion;GO:0001666,response to hypoxia;GO:0042110,T cell activation;GO:0031295,T cell costimulation	hsa:1803,path:hsa04974,Protein digestion and absorption
H13_HUMAN	P16402	H1-3	Histone H1.3	4.915914369	14.97143216	3.370262301	2.094276751	9.9436732645	2.732269526	9.9436732645	2.732269526	3.63934566845511	0.104438	0	0.274774668608079	0.103908	0	GO:0015629,actin cytoskeleton;GO:0000785,chromatin;GO:0000791,euchromatin;GO:0005794,Golgi apparatus;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0000786,nucleosome;GO:0005634,nucleus;GO:0017053,transcription repressor complex;GO:0000792,heterochromatin;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0001673,male germ cell nucleus;GO:0005730,nucleolus	GO:0031490,chromatin DNA binding;GO:0003690,double-stranded DNA binding;GO:0003680,minor groove of adenine-thymine-rich DNA binding;GO:0031492,nucleosomal DNA binding;GO:0003723,RNA binding;GO:0005524,ATP binding;GO:0003677,DNA binding;GO:0043531,ADP binding;GO:0016208,AMP binding;GO:0005509,calcium ion binding;GO:0032564,dATP binding;GO:0005525,GTP binding;GO:0042826,histone deacetylase binding;GO:0042393,histone binding;GO:0003676,nucleic acid binding;GO:0045296,cadherin binding	GO:0006309,apoptotic DNA fragmentation;GO:0006342,chromatin silencing;GO:0030261,chromosome condensation;GO:0031936,negative regulation of chromatin silencing;GO:0045910,negative regulation of DNA recombination;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0006334,nucleosome assembly;GO:0016584,nucleosome positioning;GO:2000679,positive regulation of transcription regulatory region DNA binding;GO:0007275,multicellular organism development;GO:0035092,sperm chromatin condensation;GO:0007290,spermatid nucleus elongation;GO:0006325,chromatin organization;GO:0071169,establishment of protein localization to chromatin;GO:0030307,positive regulation of cell growth;GO:0051574,positive regulation of histone H3-K9 methylation;GO:0050821,protein stabilization;GO:0051321,meiotic cell cycle;GO:2000737,negative regulation of stem cell differentiation;GO:0044030,regulation of DNA methylation;GO:0006338,chromatin remodeling;GO:0007281,germ cell development;GO:0006355,regulation of transcription, DNA-templated;GO:0007283,spermatogenesis;GO:0030154,cell differentiation	
THMS2_HUMAN	Q5TEJ8	THEMIS2	Protein THEMIS2	0.32175842	0.264605223	0.50637027	0.165284517	0.2931818215	0.3358273935	0.2931818215	0.3358273935	0.87301342050883	0.478713	0	1.14545776331497	0.478615	0	GO:0005737,cytoplasm;GO:0005634,nucleus		GO:0007155,cell adhesion;GO:0006954,inflammatory response;GO:0050864,regulation of B cell activation;GO:0050852,T cell receptor signaling pathway	
MYO6_HUMAN	Q9UM54	MYO6	Unconventional myosin-VI	0.700487319	0.970578167	1.746307482	1.537866753	0.835532743	1.6420871175	0.835532743	1.6420871175	0.508823639194039	0.233241	0	1.965317495044	0.233567	0	GO:0015629,actin cytoskeleton;GO:0005884,actin filament;GO:0005938,cell cortex;GO:0005905,clathrin-coated pit;GO:0030665,clathrin-coated vesicle membrane;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0030139,endocytic vesicle;GO:0070062,extracellular exosome;GO:0031941,filamentous actin;GO:0030175,filopodium;GO:0005794,Golgi apparatus;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0005902,microvillus;GO:0031965,nuclear membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0016591,RNA polymerase II, holoenzyme;GO:0001726,ruffle;GO:0032587,ruffle membrane;GO:0016461,unconventional myosin complex;GO:0031982,vesicle;GO:0016459,myosin complex;GO:0030136,clathrin-coated vesicle;GO:0045177,apical part of cell	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0030898,actin-dependent ATPase activity;GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0005516,calmodulin binding;GO:0042802,identical protein binding;GO:0000146,microfilament motor activity;GO:0060001,minus-end directed microfilament motor activity;GO:0003774,motor activity	GO:0007015,actin filament organization;GO:0030048,actin filament-based movement;GO:0030330,DNA damage response, signal transduction by p53 class mediator;GO:0006897,endocytosis;GO:0042491,inner ear auditory receptor cell differentiation;GO:0042472,inner ear morphogenesis;GO:0006886,intracellular protein transport;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0051046,regulation of secretion;GO:0007605,sensory perception of sound;GO:0030050,vesicle transport along actin filament;GO:0015031,protein transport;GO:0042493,response to drug	hsa:4646,path:hsa05130,Pathogenic Escherichia coli infection;hsa:4646,path:hsa05132,Salmonella infection
CO7_HUMAN	P10643	C7	Complement component C7	0.141127386	0.438850478	0.55215313	2.781665819	0.289988932	1.6669094745	0.289988932	1.6669094745	0.173968014721966	0.008934	-1	5.74818308755315	0.009005	1	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005579,membrane attack complex		GO:0006883,cellular sodium ion homeostasis;GO:0006956,complement activation;GO:0006957,complement activation, alternative pathway;GO:0006958,complement activation, classical pathway;GO:0019835,cytolysis;GO:0030449,regulation of complement activation	hsa:730,path:hsa04610,Complement and coagulation cascades;hsa:730,path:hsa05322,Systemic lupus erythematosus;hsa:730,path:hsa05020,Prion diseases
CALX_HUMAN	P27824	CANX	Calnexin	11.08378824	10.22322507	18.11715299	12.71214662	10.653506655	15.414649805	10.653506655	15.414649805	0.691128685359064	0.397340	0	1.44690854421774	0.397543	0	GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0042470,melanosome;GO:0016020,membrane;GO:0044233,mitochondria-associated endoplasmic reticulum membrane;GO:0098793,presynapse	GO:0005509,calcium ion binding;GO:0030246,carbohydrate binding;GO:0003723,RNA binding;GO:0051082,unfolded protein binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0072583,clathrin-dependent endocytosis;GO:0030968,endoplasmic reticulum unfolded protein response;GO:0070106,interleukin-27-mediated signaling pathway;GO:0070757,interleukin-35-mediated signaling pathway;GO:0006457,protein folding;GO:0034975,protein folding in endoplasmic reticulum;GO:0009306,protein secretion;GO:0048488,synaptic vesicle endocytosis;GO:0019082,viral protein processing	hsa:821,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:821,path:hsa04145,Phagosome;hsa:821,path:hsa04612,Antigen processing and presentation;hsa:821,path:hsa04918,Thyroid hormone synthesis;hsa:821,path:hsa05166,Human T-cell leukemia virus 1 infection
CLIP1_HUMAN	P30622	CLIP1	CAP-Gly domain-containing linker protein 1	0.150775366	0.117859933	0.188808887	0.069969123	0.1343176495	0.129389005	0.1343176495	0.129389005	1.03809167942825	0.420991	0	0.963306054577734	0.420768	0	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0005882,intermediate filament;GO:0000776,kinetochore;GO:0005874,microtubule;GO:0015630,microtubule cytoskeleton;GO:0005634,nucleus;GO:0001726,ruffle	GO:0042802,identical protein binding;GO:0008017,microtubule binding;GO:0051010,microtubule plus-end binding;GO:0015631,tubulin binding;GO:0008270,zinc ion binding	GO:0031122,cytoplasmic microtubule organization;GO:0001578,microtubule bundle formation;GO:0000278,mitotic cell cycle;GO:0007052,mitotic spindle organization;GO:0031116,positive regulation of microtubule polymerization	hsa:6249,path:hsa04150,mTOR signaling pathway
RENR_HUMAN	O75787	ATP6AP2	Renin receptor	0.208305772	0.241490534	0.200169928	0.110702821	0.224898153	0.1554363745	0.224898153	0.1554363745	1.44688238981024	0.315894	0	0.691141178469349	0.315469	0	GO:0016324,apical plasma membrane;GO:0000421,autophagosome membrane;GO:0030424,axon;GO:0044297,cell body;GO:0032591,dendritic spine membrane;GO:0005789,endoplasmic reticulum membrane;GO:0010008,endosome membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0101003,ficolin-1-rich granule membrane;GO:0016021,integral component of membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0005886,plasma membrane;GO:0045211,postsynaptic membrane;GO:0070821,tertiary granule membrane;GO:0016471,vacuolar proton-transporting V-type ATPase complex	GO:0038023,signaling receptor activity;GO:0003824,catalytic activity	GO:0002003,angiotensin maturation;GO:0021626,central nervous system maturation;GO:0048069,eye pigmentation;GO:0060323,head morphogenesis;GO:0007042,lysosomal lumen acidification;GO:0043312,neutrophil degranulation;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0032914,positive regulation of transforming growth factor beta1 production;GO:0030177,positive regulation of Wnt signaling pathway;GO:0043408,regulation of MAPK cascade;GO:0021903,rostrocaudal neural tube patterning	hsa:10159,path:hsa04614,Renin-angiotensin system
S12A2_HUMAN	P55011	SLC12A2	Solute carrier family 12 member 2	8.492360151	0.623443091	2.627235741	1.337579828	4.557901621	1.9824077845	4.557901621	1.9824077845	2.29917459800007	0.192266	0	0.434938695334337	0.191702	0	GO:0016324,apical plasma membrane;GO:0009925,basal plasma membrane;GO:0016323,basolateral plasma membrane;GO:0044297,cell body;GO:0044298,cell body membrane;GO:0071944,cell periphery;GO:0042995,cell projection;GO:0031253,cell projection membrane;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:1903561,extracellular vesicle;GO:0005887,integral component of plasma membrane;GO:0016328,lateral plasma membrane;GO:0016020,membrane;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0008519,ammonium transmembrane transporter activity;GO:0015377,cation;GO:0051087,chaperone binding;GO:0051879,Hsp90 protein binding;GO:0046873,metal ion transmembrane transporter activity;GO:0015079,potassium ion transmembrane transporter activity;GO:0015379,potassium;GO:0019901,protein kinase binding;GO:0008511,sodium	GO:0007568,aging;GO:0015696,ammonium transport;GO:0006884,cell volume homeostasis;GO:0030644,cellular chloride ion homeostasis;GO:0030007,cellular potassium ion homeostasis;GO:1990869,cellular response to chemokine;GO:0035865,cellular response to potassium ion;GO:0006883,cellular sodium ion homeostasis;GO:0055064,chloride ion homeostasis;GO:1902476,chloride transmembrane transport;GO:0007214,gamma-aminobutyric acid signaling pathway;GO:0006972,hyperosmotic response;GO:0098658,inorganic anion import across plasma membrane;GO:0098659,inorganic cation import across plasma membrane;GO:0006811,ion transport;GO:0035633,maintenance of blood-brain barrier;GO:0061044,negative regulation of vascular wound healing;GO:1904450,positive regulation of aspartate secretion;GO:0045795,positive regulation of cell volume;GO:0055075,potassium ion homeostasis;GO:1990573,potassium ion import across plasma membrane;GO:1904464,regulation of matrix metallopeptidase secretion;GO:0150003,regulation of spontaneous synaptic transmission;GO:0055078,sodium ion homeostasis;GO:0098719,sodium ion import across plasma membrane;GO:0035725,sodium ion transmembrane transport;GO:0010818,T cell chemotaxis;GO:0070634,transepithelial ammonium transport;GO:0030321,transepithelial chloride transport;GO:0150104,transport across blood-brain barrier;GO:0006814,sodium ion transport	hsa:6558,path:hsa04970,Salivary secretion;hsa:6558,path:hsa04972,Pancreatic secretion;hsa:6558,path:hsa05110,Vibrio cholerae infection
CP1B1_HUMAN	Q16678	CYP1B1	Cytochrome P450 1B1	0.245634661	0.382278914	0.606621868	0.248755143	0.3139567875	0.4276885055	0.3139567875	0.4276885055	0.734078151417609	0.433252	0	1.36225277658633	0.433417	0	GO:0005789,endoplasmic reticulum membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005739,mitochondrion;GO:0016021,integral component of membrane	GO:0070330,aromatase activity;GO:0101020,estrogen 16-alpha-hydroxylase activity;GO:0020037,heme binding;GO:0106256,hydroperoxy icosatetraenoate dehydratase activity;GO:0005506,iron ion binding;GO:0004497,monooxygenase activity;GO:0016712,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0016705,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0001525,angiogenesis;GO:0019369,arachidonic acid metabolic process;GO:0048514,blood vessel morphogenesis;GO:0007155,cell adhesion;GO:0006725,cellular aromatic compound metabolic process;GO:0070301,cellular response to hydrogen peroxide;GO:0071407,cellular response to organic cyclic compound;GO:0030199,collagen fibril organization;GO:0043542,endothelial cell migration;GO:0071603,endothelial cell-cell adhesion;GO:0019373,epoxygenase P450 pathway;GO:0008210,estrogen metabolic process;GO:0008631,intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0046466,membrane lipid catabolic process;GO:0033629,negative regulation of cell adhesion mediated by integrin;GO:0030336,negative regulation of cell migration;GO:0008285,negative regulation of cell population proliferation;GO:0032088,negative regulation of NF-kappaB transcription factor activity;GO:0006809,nitric oxide biosynthetic process;GO:0097267,omega-hydroxylase P450 pathway;GO:0045766,positive regulation of angiogenesis;GO:0043065,positive regulation of apoptotic process;GO:0046427,positive regulation of receptor signaling pathway via JAK-STAT;GO:0010575,positive regulation of vascular endothelial growth factor production;GO:2000377,regulation of reactive oxygen species metabolic process;GO:0009636,response to toxic substance;GO:0061304,retinal blood vessel morphogenesis;GO:0042574,retinal metabolic process;GO:0042572,retinol metabolic process;GO:0008202,steroid metabolic process;GO:0016125,sterol metabolic process;GO:0009404,toxin metabolic process;GO:0002930,trabecular meshwork development;GO:0006805,xenobiotic metabolic process	hsa:1545,path:hsa00140,Steroid hormone biosynthesis;hsa:1545,path:hsa00380,Tryptophan metabolism;hsa:1545,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:1545,path:hsa04913,Ovarian steroidogenesis;hsa:1545,path:hsa05206,MicroRNAs in cancer;hsa:1545,path:hsa05204,Chemical carcinogenesis
CYRIB_HUMAN	Q9NUQ9	CYRIB	CYFIP-related Rac1 interactor B	3.829069167	4.103814006	4.221404531	2.030843203	3.9664415865	3.126123867	3.9664415865	3.126123867	1.2688049978987	0.356245	0	0.788143175394271	0.355892	0	GO:0005929,cilium;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0031093,platelet alpha granule lumen	GO:0023030,MHC class Ib protein binding, via antigen binding groove;GO:0031267,small GTPase binding	GO:0071219,cellular response to molecule of bacterial origin;GO:0030837,negative regulation of actin filament polymerization;GO:0051058,negative regulation of small GTPase mediated signal transduction;GO:0002576,platelet degranulation;GO:0032729,positive regulation of interferon-gamma production;GO:2000568,positive regulation of memory T cell activation;GO:0050870,positive regulation of T cell activation;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:0030334,regulation of cell migration;GO:0050920,regulation of chemotaxis;GO:2000114,regulation of establishment of cell polarity;GO:0090140,regulation of mitochondrial fission;GO:0030833,regulation of actin filament polymerization	
KBP_HUMAN	Q96EK5	KIFBP	KIF-binding protein	0.21365601	0.244183619	0.188554473	0.281860474	0.2289198145	0.2352074735	0.2289198145	0.2352074735	0.973267605376493	0.442351	0	1.02746664378413	0.442174	0	GO:0005856,cytoskeleton;GO:0005739,mitochondrion;GO:0005737,cytoplasm	GO:0019894,kinesin binding	GO:0030154,cell differentiation;GO:0006839,mitochondrial transport;GO:0007399,nervous system development;GO:0001701,in utero embryonic development	
MTX1_HUMAN	Q13505	MTX1	Metaxin-1	0.042001707	0.133823919	0.263064818	0.207270836	0.087912813	0.235167827	0.087912813	0.235167827	0.373830103043815	0.115193	0	2.67501196896066	0.115506	0	GO:0005737,cytoplasm;GO:0016021,integral component of membrane;GO:0140275,MIB complex;GO:0001401,SAM complex		GO:0007007,inner mitochondrial membrane organization;GO:0007595,lactation;GO:0007005,mitochondrion organization;GO:0015031,protein transport	
SUMF2_HUMAN	Q8NBJ7	SUMF2	Inactive C-alpha-formylglycine-generating enzyme 2	0.431790815	1.461550681	2.063413408	0.838211166	0.946670748	1.450812287	0.946670748	1.450812287	0.652510842706972	0.363880	0	1.53254158329608	0.364115	0	GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen	GO:0046872,metal ion binding	GO:0006687,glycosphingolipid metabolic process;GO:0043687,post-translational protein modification	
NIF3L_HUMAN	Q9GZT8	NIF3L1	NIF3-like protein 1	0.256060523	0.071720174	0.432175533	0.656308026	0.1638903485	0.5442417795	0.1638903485	0.5442417795	0.301135184164964	0.063030	0	3.32076772354902	0.063276	0	GO:0005737,cytoplasm;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0042802,identical protein binding;GO:0008134,transcription factor binding	GO:1903507,negative regulation of nucleic acid-templated transcription;GO:0030182,neuron differentiation;GO:0045893,positive regulation of transcription, DNA-templated	
ARAP1_HUMAN	Q96P48	ARAP1	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1	0.303390269	0.381774243	0.659235193	0.565110176	0.342582256	0.6121726845	0.342582256	0.6121726845	0.559617024205855	0.280013	0	1.7869363452963	0.280315	0	GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0032580,Golgi cisterna membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0005802,trans-Golgi network	GO:0005096,GTPase activator activity;GO:0046872,metal ion binding;GO:0005547,phosphatidylinositol-3,4,5-trisphosphate binding;GO:0031702,type 1 angiotensin receptor binding	GO:0030037,actin filament reorganization involved in cell cycle;GO:0051497,negative regulation of stress fiber assembly;GO:0045742,positive regulation of epidermal growth factor receptor signaling pathway;GO:0051491,positive regulation of filopodium assembly;GO:0043547,positive regulation of GTPase activity;GO:0001921,positive regulation of receptor recycling;GO:0008360,regulation of cell shape;GO:0051270,regulation of cellular component movement;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007165,signal transduction	hsa:116985,path:hsa04144,Endocytosis
UBE2H_HUMAN	P62256	UBE2H	Ubiquitin-conjugating enzyme E2 H	0.421403932	0.849231748	0.028516257	0.013722181	0.63531784	0.021119219	0.63531784	0.021119219	30.0824495451276	0.001195	1	0.0332419738126667	0.001168	-1	GO:0005829,cytosol;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0061631,ubiquitin conjugating enzyme activity;GO:0004842,ubiquitin-protein transferase activity;GO:0016740,transferase activity	GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070979,protein K11-linked ubiquitination;GO:0070936,protein K48-linked ubiquitination;GO:0000209,protein polyubiquitination;GO:0016567,protein ubiquitination;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:7328,path:hsa04120,Ubiquitin mediated proteolysis
ARC1A_HUMAN	Q92747	ARPC1A	Actin-related protein 2/3 complex subunit 1A	0.424464296	0.301824075	0.438518421	0.224587504	0.3631441855	0.3315529625	0.3631441855	0.3315529625	1.09528258400044	0.403399	0	0.913006391782087	0.403139	0	GO:0015629,actin cytoskeleton;GO:0005885,Arp2/3 protein complex;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus;GO:0035861,site of double-strand break	GO:0003779,actin binding;GO:0051015,actin filament binding	GO:0030036,actin cytoskeleton organization;GO:0034314,Arp2/3 complex-mediated actin nucleation;GO:0048013,ephrin receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0061024,membrane organization	hsa:10552,path:hsa04144,Endocytosis;hsa:10552,path:hsa04810,Regulation of actin cytoskeleton;hsa:10552,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:10552,path:hsa05130,Pathogenic Escherichia coli infection;hsa:10552,path:hsa05132,Salmonella infection;hsa:10552,path:hsa05131,Shigellosis;hsa:10552,path:hsa05100,Bacterial invasion of epithelial cells
BCKD_HUMAN	O14874	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	0.354201497	0.235512887	0.384833317	0.081379083	0.294857192	0.2331062	0.294857192	0.2331062	1.26490497464246	0.357213	0	0.790573220950975	0.356861	0	GO:0005947,mitochondrial alpha-ketoglutarate dehydrogenase complex;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0047323,[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity;GO:0005524,ATP binding;GO:0016301,kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0004740,pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0004672,protein kinase activity	GO:0009083,branched-chain amino acid catabolic process;GO:0009063,cellular amino acid catabolic process;GO:0006550,isoleucine catabolic process;GO:0006552,leucine catabolic process;GO:0045763,negative regulation of cellular amino acid metabolic process;GO:0016310,phosphorylation;GO:0006468,protein phosphorylation;GO:0010906,regulation of glucose metabolic process;GO:0007283,spermatogenesis;GO:0006574,valine catabolic process	
MYH7_HUMAN	P12883	MYH7	Myosin-7	0.065685986	0.124477558	0.035023772	4.203633334	0.095081772	2.119328553	0.095081772	2.119328553	0.0448641018238572	0.000005	-1	22.2895357166882	0.000005	1	GO:0005859,muscle myosin complex;GO:0030016,myofibril;GO:0016459,myosin complex;GO:0032982,myosin filament;GO:0030017,sarcomere;GO:0001725,stress fiber;GO:0030018,Z disc	GO:0051015,actin filament binding;GO:0030898,actin-dependent ATPase activity;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0005516,calmodulin binding;GO:0000146,microfilament motor activity	GO:0007512,adult heart development;GO:0046034,ATP metabolic process;GO:0060048,cardiac muscle contraction;GO:0014898,cardiac muscle hypertrophy in response to stress;GO:0006936,muscle contraction;GO:0030049,muscle filament sliding;GO:0002027,regulation of heart rate;GO:0031449,regulation of slow-twitch skeletal muscle fiber contraction;GO:0002026,regulation of the force of heart contraction;GO:0014728,regulation of the force of skeletal muscle contraction;GO:0003009,skeletal muscle contraction;GO:0006941,striated muscle contraction;GO:0014883,transition between fast and slow fiber;GO:0055010,ventricular cardiac muscle tissue morphogenesis	hsa:4625,path:hsa04022,cGMP-PKG signaling pathway;hsa:4625,path:hsa04919,Thyroid hormone signaling pathway;hsa:4625,path:hsa04260,Cardiac muscle contraction;hsa:4625,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:4625,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:4625,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:4625,path:hsa05416,Viral myocarditis
CP2S1_HUMAN	Q96SQ9	CYP2S1	Cytochrome P450 2S1	0.746513613	0.310981635	0.949319973	0.417187563	0.528747624	0.683253768	0.528747624	0.683253768	0.773867117553898	0.465163	0	1.29221151450508	0.465293	0	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016021,integral component of membrane	GO:0036134,12-hydroxyheptadecatrienoic acid synthase activity;GO:0008392,arachidonic acid epoxygenase activity;GO:0020037,heme binding;GO:0016836,hydro-lyase activity;GO:0106256,hydroperoxy icosatetraenoate dehydratase activity;GO:0005506,iron ion binding;GO:0004497,monooxygenase activity;GO:0016712,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008395,steroid hydroxylase activity;GO:0004796,thromboxane-A synthase activity;GO:0016705,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0019373,epoxygenase P450 pathway;GO:0042738,exogenous drug catabolic process;GO:0006690,icosanoid metabolic process;GO:0006082,organic acid metabolic process;GO:0006693,prostaglandin metabolic process;GO:0042573,retinoic acid metabolic process;GO:0006805,xenobiotic metabolic process	hsa:29785,path:hsa00830,Retinol metabolism;hsa:29785,path:hsa00980,Metabolism of xenobiotics by cytochrome P450
AP4S1_HUMAN	Q9Y587	AP4S1	AP-4 complex subunit sigma-1	0.383324898	0.198542331	0.136539278	1.998201151	0.2909336145	1.0673702145	0.2909336145	1.0673702145	0.272570482619552	0.046271	-1	3.6687758351141	0.046481	1	GO:0030124,AP-4 adaptor complex;GO:0031904,endosome lumen;GO:0043231,intracellular membrane-bounded organelle;GO:0032588,trans-Golgi network membrane;GO:0016020,membrane		GO:0006892,post-Golgi vesicle-mediated transport;GO:0008104,protein localization;GO:0006605,protein targeting;GO:0016192,vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0015031,protein transport	hsa:11154,path:hsa04142,Lysosome
CSK_HUMAN	P41240	CSK	Tyrosine-protein kinase CSK	1.024232054	1.331203182	2.223190129	1.258228369	1.177717618	1.740709249	1.177717618	1.740709249	0.676573424698337	0.384851	0	1.4780361798069	0.385066	0	GO:0005911,cell-cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0045121,membrane raft;GO:0005886,plasma membrane	GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0004715,non-membrane spanning protein tyrosine kinase activity;GO:0070064,proline-rich region binding;GO:0008022,protein C-terminus binding;GO:0034236,protein kinase A catalytic subunit binding;GO:0019903,protein phosphatase binding;GO:0004713,protein tyrosine kinase activity;GO:0004714,transmembrane receptor protein tyrosine kinase activity	GO:0002250,adaptive immune response;GO:0034332,adherens junction organization;GO:0007420,brain development;GO:0071375,cellular response to peptide hormone stimulus;GO:0019221,cytokine-mediated signaling pathway;GO:0045779,negative regulation of bone resorption;GO:0008285,negative regulation of cell population proliferation;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:0042997,negative regulation of Golgi to plasma membrane protein transport;GO:0032715,negative regulation of interleukin-6 production;GO:0033673,negative regulation of kinase activity;GO:0010989,negative regulation of low-density lipoprotein particle clearance;GO:0050765,negative regulation of phagocytosis;GO:0048709,oligodendrocyte differentiation;GO:0043406,positive regulation of MAP kinase activity;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:0060368,regulation of Fc receptor mediated stimulatory signaling pathway;GO:0031295,T cell costimulation;GO:0050852,T cell receptor signaling pathway	hsa:1445,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection
LSM3_HUMAN	P62310	LSM3	U6 snRNA-associated Sm-like protein LSm3	0.970112595	1.648822339	0.165920573	0.083801963	1.309467467	0.124861268	1.309467467	0.124861268	10.487379216748	0.015828	1	0.0953527072238443	0.015634	-1	GO:0071013,catalytic step 2 spliceosome;GO:0005829,cytosol;GO:1990726,Lsm1-7-Pat1 complex;GO:0120115,Lsm2-8 complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body;GO:0071011,precatalytic spliceosome;GO:0071005,U2-type precatalytic spliceosome;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005688,U6 snRNP	GO:0003723,RNA binding;GO:0030629,U6 snRNA 3'-end binding	GO:0043928,exonucleolytic catabolism of deadenylated mRNA;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0033962,P-body assembly	hsa:27258,path:hsa03040,Spliceosome;hsa:27258,path:hsa03018,RNA degradation
PAIP1_HUMAN	Q9H074	PAIP1	Polyadenylate-binding protein-interacting protein 1	0.616898838	0.306362428	0.542035279	0.646295428	0.461630633	0.5941653535	0.461630633	0.5941653535	0.776939668866101	0.467570	0	1.28710122558093	0.467697	0	GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0003723,RNA binding;GO:0008494,translation activator activity	GO:0048255,mRNA stabilization;GO:0006446,regulation of translational initiation;GO:0006413,translational initiation	hsa:10605,path:hsa03013,RNA transport
CP27A_HUMAN	Q02318	CYP27A1	Sterol 26-hydroxylase, mitochondrial	2.69407937	3.392610896	4.16262706	4.715179712	3.043345133	4.438903386	3.043345133	4.438903386	0.685607427861238	0.392621	0	1.45856062720836	0.392828	0	GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0047748,cholestanetetraol 26-dehydrogenase activity;GO:0047749,cholestanetriol 26-monooxygenase activity;GO:0031073,cholesterol 26-hydroxylase activity;GO:0020037,heme binding;GO:0005506,iron ion binding;GO:0008395,steroid hydroxylase activity;GO:0030343,vitamin D3 25-hydroxylase activity;GO:0016705,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0006699,bile acid biosynthetic process;GO:0036378,calcitriol biosynthetic process from calciol;GO:0006707,cholesterol catabolic process;GO:0008203,cholesterol metabolic process;GO:0016125,sterol metabolic process	hsa:1593,path:hsa00120,Primary bile acid biosynthesis;hsa:1593,path:hsa03320,PPAR signaling pathway;hsa:1593,path:hsa04979,Cholesterol metabolism
VPS41_HUMAN	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.245112832	0.224324832	0.252403502	0.1395731	0.234718832	0.195988301	0.234718832	0.195988301	1.19761654548962	0.374543	0	0.834991804151445	0.374225	0	GO:0030123,AP-3 adaptor complex;GO:0030136,clathrin-coated vesicle;GO:0005829,cytosol;GO:0005769,early endosome;GO:0010008,endosome membrane;GO:0005794,Golgi apparatus;GO:0005798,Golgi-associated vesicle;GO:0030897,HOPS complex;GO:0005770,late endosome;GO:0031902,late endosome membrane;GO:1902501,lysosomal HOPS complex;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0016020,membrane;GO:0015630,microtubule cytoskeleton	GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0008017,microtubule binding;GO:0043621,protein self-association	GO:0009267,cellular response to starvation;GO:0034058,endosomal vesicle fusion;GO:0008333,endosome to lysosome transport;GO:0048193,Golgi vesicle transport;GO:1902774,late endosome to lysosome transport;GO:0016236,macroautophagy;GO:0006623,protein targeting to vacuole;GO:0045055,regulated exocytosis;GO:0006886,intracellular protein transport;GO:0016192,vesicle-mediated transport	hsa:27072,path:hsa05132,Salmonella infection
FSP1_HUMAN	Q9BRQ8	AIFM2	Ferroptosis suppressor protein 1	0.080238586	0.076971523	0.078001387	2.55E-05	0.0786050545	0.0390134435	0.0786050545	0.0390134435	2.01481969926597	0.224136	0	0.496322326193413	0.223592	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005615,extracellular space;GO:0016021,integral component of membrane;GO:0005811,lipid droplet;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0003677,DNA binding;GO:0004174,electron-transferring-flavoprotein dehydrogenase activity;GO:0050660,flavin adenine dinucleotide binding;GO:0016655,oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	GO:0008637,apoptotic mitochondrial changes;GO:0110076,negative regulation of ferroptosis;GO:0043065,positive regulation of apoptotic process;GO:0042981,regulation of apoptotic process;GO:1900407,regulation of cellular response to oxidative stress;GO:0006743,ubiquinone metabolic process	hsa:84883,path:hsa04115,p53 signaling pathway
PEPL_HUMAN	O60437	PPL	Periplakin	0.937650857	1.646075288	1.720469405	4.227985834	1.2918630725	2.9742276195	1.2918630725	2.9742276195	0.43435245642604	0.166011	0	2.30227775900762	0.166346	0	GO:0001533,cornified envelope;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0030057,desmosome;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0045296,cadherin binding;GO:0005200,structural constituent of cytoskeleton;GO:0005198,structural molecule activity	GO:0002250,adaptive immune response;GO:0070268,cornification;GO:0045104,intermediate filament cytoskeleton organization;GO:0009612,response to mechanical stimulus;GO:0042060,wound healing	
GTF2I_HUMAN	P78347	GTF2I	General transcription factor II-I	3.137906831	3.501827295	4.16155674	8.929356931	3.319867063	6.5454568355	3.319867063	6.5454568355	0.507201734949093	0.231751	0	1.97160208866472	0.232077	0	GO:0005737,cytoplasm;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0001228,DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700,DNA-binding transcription factor activity;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001102,RNA polymerase II activating transcription factor binding	GO:0016525,negative regulation of angiogenesis;GO:0100026,positive regulation of DNA repair by transcription from RNA polymerase II promoter;GO:0051481,negative regulation of cytosolic calcium ion concentration;GO:0006366,transcription by RNA polymerase II	hsa:2969,path:hsa03022,Basal transcription factors;hsa:2969,path:hsa04022,cGMP-PKG signaling pathway
HSDL2_HUMAN	Q6YN16	HSDL2	Hydroxysteroid dehydrogenase-like protein 2	0.324579373	0.243571472	1.080149962	1.022081254	0.2840754225	1.051115608	0.2840754225	1.051115608	0.270260873625996	0.045025	-1	3.70012864453277	0.045231	1	GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005777,peroxisome	GO:0016491,oxidoreductase activity		
EIF3L_HUMAN	Q9Y262	EIF3L	Eukaryotic translation initiation factor 3 subunit L	12.24982095	6.498819125	11.81514108	29.91321204	9.3743200375	20.86417656	9.3743200375	20.86417656	0.449302181207194	0.179222	0	2.22567359302192	0.179558	0	GO:0005829,cytosol;GO:0016282,eukaryotic 43S preinitiation complex;GO:0033290,eukaryotic 48S preinitiation complex;GO:0005852,eukaryotic translation initiation factor 3 complex;GO:0016020,membrane;GO:0001650,fibrillar center;GO:0005654,nucleoplasm	GO:0003723,RNA binding;GO:0003743,translation initiation factor activity	GO:0001732,formation of cytoplasmic translation initiation complex;GO:0006413,translational initiation;GO:0075525,viral translational termination-reinitiation	
TCTP_HUMAN	P13693	TPT1	Translationally-controlled tumor protein	2.875783246	15.03704234	0.864166547	0.252399175	8.956412793	0.558282861	8.956412793	0.558282861	16.0427865848456	0.006088	1	0.0623333106571789	0.005990	-1	GO:0005737,cytoplasm;GO:0005881,cytoplasmic microtubule;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005771,multivesicular body;GO:0005634,nucleus;GO:0000922,spindle pole	GO:0005509,calcium ion binding;GO:0003723,RNA binding	GO:0006816,calcium ion transport;GO:0006874,cellular calcium ion homeostasis;GO:0043066,negative regulation of apoptotic process;GO:1902230,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0042981,regulation of apoptotic process;GO:0009615,response to virus	
HIKES_HUMAN	Q53FT3	HIKESHI	Protein Hikeshi	0.190277185	0.427369279	0.023515771	0.004909267	0.308823232	0.014212519	0.308823232	0.014212519	21.7289582515246	0.002866	1	0.0460215344161672	0.002811	-1	GO:0005829,cytosol;GO:0016604,nuclear body;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0030544,Hsp70 protein binding;GO:0061608,nuclear import signal receptor activity	GO:0034605,cellular response to heat;GO:0007030,Golgi organization;GO:0030324,lung development;GO:0006606,protein import into nucleus;GO:0015031,protein transport;GO:1900034,regulation of cellular response to heat	
RHOC_HUMAN	P08134	RHOC	Rho-related GTP-binding protein RhoC	0.34468643	1.340695413	0.064326954	2.55E-05	0.8426909215	0.032176227	0.8426909215	0.032176227	26.1898612755312	0.001750	1	0.0381827146573811	0.001713	-1	GO:0005938,cell cortex;GO:0042995,cell projection;GO:0032154,cleavage furrow;GO:0031410,cytoplasmic vesicle;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0043005,neuron projection;GO:0005886,plasma membrane;GO:0032420,stereocilium	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0019901,protein kinase binding	GO:0007015,actin filament organization;GO:0043297,apical junction assembly;GO:0016477,cell migration;GO:0030865,cortical cytoskeleton organization;GO:0007163,establishment or maintenance of cell polarity;GO:0007186,G protein-coupled receptor signaling pathway;GO:0000281,mitotic cytokinesis;GO:0030335,positive regulation of cell migration;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0060193,positive regulation of lipase activity;GO:0031334,positive regulation of protein-containing complex assembly;GO:0051496,positive regulation of stress fiber assembly;GO:0032956,regulation of actin cytoskeleton organization;GO:0008360,regulation of cell shape;GO:0051056,regulation of small GTPase mediated signal transduction;GO:1902766,skeletal muscle satellite cell migration;GO:0007264,small GTPase mediated signal transduction;GO:0044319,wound healing, spreading of cells	
VPP3_HUMAN	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a3	0.72318899	1.246800255	0.915402795	0.646954108	0.9849946225	0.7811784515	0.9849946225	0.7811784515	1.26090859343168	0.358208	0	0.79307889977846	0.357859	0	GO:0016324,apical plasma membrane;GO:0010008,endosome membrane;GO:0101003,ficolin-1-rich granule membrane;GO:0005887,integral component of plasma membrane;GO:0005770,late endosome;GO:0005765,lysosomal membrane;GO:0005634,nucleus;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0016471,vacuolar proton-transporting V-type ATPase complex;GO:0000220,vacuolar proton-transporting V-type ATPase, V0 domain;GO:0016021,integral component of membrane;GO:0033179,proton-transporting V-type ATPase, V0 domain	GO:0051117,ATPase binding;GO:0046961,proton-transporting ATPase activity, rotational mechanism;GO:0005215,transporter activity;GO:0015078,proton transmembrane transporter activity	GO:0006915,apoptotic process;GO:0000045,autophagosome assembly;GO:0030183,B cell differentiation;GO:0045453,bone resorption;GO:0006874,cellular calcium ion homeostasis;GO:0006968,cellular defense response;GO:0034198,cellular response to amino acid starvation;GO:0071345,cellular response to cytokine stimulus;GO:0097188,dentin mineralization;GO:0070166,enamel mineralization;GO:0030010,establishment of cell polarity;GO:0051650,establishment of vesicle localization;GO:0010467,gene expression;GO:0061484,hematopoietic stem cell homeostasis;GO:0016064,immunoglobulin mediated immune response;GO:0006954,inflammatory response;GO:0008286,insulin receptor signaling pathway;GO:0034220,ion transmembrane transport;GO:0016236,macroautophagy;GO:0035709,memory T cell activation;GO:0043312,neutrophil degranulation;GO:0021554,optic nerve development;GO:0001503,ossification;GO:0030316,osteoclast differentiation;GO:0002158,osteoclast proliferation;GO:0090383,phagosome acidification;GO:0008284,positive regulation of cell population proliferation;GO:0007039,protein catabolic process in the vacuole;GO:0033365,protein localization to organelle;GO:1902600,proton transmembrane transport;GO:0010468,regulation of gene expression;GO:0050796,regulation of insulin secretion;GO:0045667,regulation of osteoblast differentiation;GO:0010155,regulation of proton transport;GO:0010272,response to silver ion;GO:0060041,retina development in camera-type eye;GO:0031529,ruffle organization;GO:0030217,T cell differentiation;GO:0043029,T cell homeostasis;GO:0035711,T-helper 1 cell activation;GO:0044691,tooth eruption;GO:0033572,transferrin transport;GO:0007035,vacuolar acidification	hsa:10312,path:hsa00190,Oxidative phosphorylation;hsa:10312,path:hsa04145,Phagosome;hsa:10312,path:hsa04142,Lysosome;hsa:10312,path:hsa04966,Collecting duct acid secretion;hsa:10312,path:hsa04721,Synaptic vesicle cycle;hsa:10312,path:hsa05323,Rheumatoid arthritis;hsa:10312,path:hsa05110,Vibrio cholerae infection;hsa:10312,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:10312,path:hsa05152,Tuberculosis;hsa:10312,path:hsa05165,Human papillomavirus infection
BAP31_HUMAN	P51572	BCAP31	B-cell receptor-associated protein 31	4.777903528	4.335931569	2.948622767	5.184016205	4.5569175485	4.066319486	4.5569175485	4.066319486	1.12064916792423	0.395945	0	0.892339929946398	0.395669	0	GO:0030136,clathrin-coated vesicle;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0032580,Golgi cisterna membrane;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0005887,integral component of plasma membrane;GO:0005811,lipid droplet;GO:0016020,membrane;GO:0044233,mitochondria-associated endoplasmic reticulum membrane;GO:0005739,mitochondrion;GO:0097038,perinuclear endoplasmic reticulum;GO:0016021,integral component of membrane	GO:0042288,MHC class I protein binding;GO:0044877,protein-containing complex binding	GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0006915,apoptotic process;GO:0035584,calcium-mediated signaling using intracellular calcium source;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0032471,negative regulation of endoplasmic reticulum calcium ion concentration;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007204,positive regulation of cytosolic calcium ion concentration;GO:1903071,positive regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:2001244,positive regulation of intrinsic apoptotic signaling pathway;GO:0051561,positive regulation of mitochondrial calcium ion concentration;GO:1904154,positive regulation of retrograde protein transport, ER to cytosol;GO:0070973,protein localization to endoplasmic reticulum exit site;GO:0006626,protein targeting to mitochondrion;GO:0034976,response to endoplasmic reticulum stress;GO:0007283,spermatogenesis;GO:0016032,viral process;GO:0006886,intracellular protein transport	hsa:10134,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:10134,path:hsa05165,Human papillomavirus infection
LPP_HUMAN	Q93052	LPP	Lipoma-preferred partner	1.360675314	1.373503576	1.517324978	2.226233382	1.367089445	1.87177918	1.367089445	1.87177918	0.730368977071323	0.430209	0	1.36917096891199	0.430377	0	GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0001725,stress fiber	GO:0046872,metal ion binding	GO:0098609,cell-cell adhesion	
LIMA1_HUMAN	Q9UHB6	LIMA1	LIM domain and actin-binding protein 1	1.219137441	1.588041905	1.308345207	1.041568328	1.403589673	1.1749567675	1.403589673	1.1749567675	1.19458835577965	0.375352	0	0.837108444228344	0.375035	0	GO:0015629,actin cytoskeleton;GO:0031526,brush border membrane;GO:0032154,cleavage furrow;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005886,plasma membrane;GO:0001726,ruffle;GO:0001725,stress fiber	GO:0051015,actin filament binding;GO:0003785,actin monomer binding;GO:0045296,cadherin binding;GO:0046872,metal ion binding	GO:0051017,actin filament bundle assembly;GO:0016477,cell migration;GO:0042632,cholesterol homeostasis;GO:0008203,cholesterol metabolic process;GO:0030299,intestinal cholesterol absorption;GO:0030835,negative regulation of actin filament depolymerization;GO:0031529,ruffle organization	
TIMP3_HUMAN	P35625	TIMP3	Metalloproteinase inhibitor 3	0.281895313	1.008570754	0.050954467	0.004396985	0.6452330335	0.027675726	0.6452330335	0.027675726	23.3140418249552	0.002386	1	0.0428926055596935	0.002338	-1	GO:0062023,collagen-containing extracellular matrix;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005634,nucleus;GO:0031089,platelet dense granule lumen	GO:0004857,enzyme inhibitor activity;GO:0046872,metal ion binding;GO:0008191,metalloendopeptidase inhibitor activity;GO:0002020,protease binding	GO:0010951,negative regulation of endopeptidase activity;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:0051045,negative regulation of membrane protein ectodomain proteolysis;GO:1904684,negative regulation of metalloendopeptidase activity;GO:0002576,platelet degranulation;GO:1903984,positive regulation of TRAIL-activated apoptotic signaling pathway;GO:0034097,response to cytokine;GO:0009725,response to hormone;GO:0010033,response to organic substance;GO:0007601,visual perception	hsa:7078,path:hsa05206,MicroRNAs in cancer;hsa:7078,path:hsa05205,Proteoglycans in cancer
ATPA_HUMAN	P25705	ATP5F1A	ATP synthase subunit alpha, mitochondrial	60.56870989	80.1039158	80.57790681	70.57198684	70.336312845	75.574946825	70.336312845	75.574946825	0.930682928667744	0.457275	0	1.07447979241597	0.457131	0	GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0005753,mitochondrial proton-transporting ATP synthase complex;GO:0005739,mitochondrion;GO:0005886,plasma membrane;GO:0045259,proton-transporting ATP synthase complex;GO:0045261,proton-transporting ATP synthase complex, catalytic core F(1)	GO:0043531,ADP binding;GO:0043532,angiostatin binding;GO:0005524,ATP binding;GO:0042288,MHC class I protein binding;GO:0046933,proton-transporting ATP synthase activity, rotational mechanism;GO:0003723,RNA binding	GO:0006754,ATP biosynthetic process;GO:0015986,ATP synthesis coupled proton transport;GO:0042407,cristae formation;GO:0006629,lipid metabolic process;GO:0042776,mitochondrial ATP synthesis coupled proton transport;GO:0001937,negative regulation of endothelial cell proliferation;GO:0043536,positive regulation of blood vessel endothelial cell migration;GO:0046034,ATP metabolic process;GO:1902600,proton transmembrane transport	hsa:498,path:hsa00190,Oxidative phosphorylation;hsa:498,path:hsa04714,Thermogenesis;hsa:498,path:hsa05010,Alzheimer disease;hsa:498,path:hsa05012,Parkinson disease;hsa:498,path:hsa05016,Huntington disease
UD16_HUMAN	P19224	UGT1A6	UDP-glucuronosyltransferase 1-6	0.065276785	0.053972655	0.164438256	0.117949738	0.05962472	0.141193997	0.05962472	0.141193997	0.422289341380427	0.155509	0	2.36804461303969	0.155841	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane	GO:0019899,enzyme binding;GO:0015020,glucuronosyltransferase activity;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0008194,UDP-glycosyltransferase activity	GO:0052695,cellular glucuronidation;GO:0052696,flavonoid glucuronidation;GO:2001030,negative regulation of cellular glucuronidation;GO:0045922,negative regulation of fatty acid metabolic process;GO:1904224,negative regulation of glucuronosyltransferase activity;GO:0052697,xenobiotic glucuronidation;GO:0006805,xenobiotic metabolic process	hsa:54578,path:hsa00040,Pentose and glucuronate interconversions;hsa:54578,path:hsa00053,Ascorbate and aldarate metabolism;hsa:54578,path:hsa00140,Steroid hormone biosynthesis;hsa:54578,path:hsa00830,Retinol metabolism;hsa:54578,path:hsa00860,Porphyrin and chlorophyll metabolism;hsa:54578,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:54578,path:hsa00982,Drug metabolism - cytochrome P450;hsa:54578,path:hsa00983,Drug metabolism - other enzymes;hsa:54578,path:hsa05204,Chemical carcinogenesis
ATPB_HUMAN	P06576	ATP5F1B	ATP synthase subunit beta, mitochondrial	76.55688022	69.34011542	113.64645	98.54557552	72.94849782	106.09601276	72.94849782	106.09601276	0.687570587454751	0.394301	0	1.4543961278242	0.394507	0	GO:0009986,cell surface;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005759,mitochondrial matrix;GO:0031966,mitochondrial membrane;GO:0042645,mitochondrial nucleoid;GO:0005753,mitochondrial proton-transporting ATP synthase complex;GO:0005754,mitochondrial proton-transporting ATP synthase, catalytic core;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0045259,proton-transporting ATP synthase complex;GO:0045261,proton-transporting ATP synthase complex, catalytic core F(1)	GO:0043532,angiostatin binding;GO:0005524,ATP binding;GO:0042288,MHC class I protein binding;GO:0046933,proton-transporting ATP synthase activity, rotational mechanism;GO:0046961,proton-transporting ATPase activity, rotational mechanism	GO:0001525,angiogenesis;GO:0006754,ATP biosynthetic process;GO:0098761,cellular response to interleukin-7;GO:0042407,cristae formation;GO:0006091,generation of precursor metabolites and energy;GO:0006629,lipid metabolic process;GO:0042776,mitochondrial ATP synthesis coupled proton transport;GO:0007005,mitochondrion organization;GO:0006933,negative regulation of cell adhesion involved in substrate-bound cell migration;GO:0001649,osteoblast differentiation;GO:0043536,positive regulation of blood vessel endothelial cell migration;GO:1902600,proton transmembrane transport;GO:0051453,regulation of intracellular pH	hsa:506,path:hsa00190,Oxidative phosphorylation;hsa:506,path:hsa04714,Thermogenesis;hsa:506,path:hsa05010,Alzheimer disease;hsa:506,path:hsa05012,Parkinson disease;hsa:506,path:hsa05016,Huntington disease
ETFD_HUMAN	Q16134	ETFDH	Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial	0.197965049	0.482392661	0.697095536	1.373077775	0.340178855	1.0350866555	0.340178855	1.0350866555	0.328647706153333	0.081324	0	3.04277188392559	0.081600	0	GO:0031305,integral component of mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0031966,mitochondrial membrane;GO:0016021,integral component of membrane	GO:0051539,4 iron, 4 sulfur cluster binding;GO:0009055,electron transfer activity;GO:0004174,electron-transferring-flavoprotein dehydrogenase activity;GO:0050660,flavin adenine dinucleotide binding;GO:0046872,metal ion binding;GO:0016491,oxidoreductase activity;GO:0043783,oxidoreductase activity, acting on metal ions, flavin as acceptor;GO:0048038,quinone binding;GO:0048039,ubiquinone binding	GO:0022900,electron transport chain;GO:0033539,fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0022904,respiratory electron transport chain;GO:0006979,response to oxidative stress	
S12A6_HUMAN	Q9UHW9	SLC12A6	Solute carrier family 12 member 6	0.196853532	0.200694525	0.055013262	0.393983979	0.1987740285	0.2244986205	0.1987740285	0.2244986205	0.885413139988537	0.473979	0	1.12941626325192	0.473871	0	GO:0016323,basolateral plasma membrane;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane;GO:0045202,synapse	GO:0008519,ammonium transmembrane transporter activity;GO:0015079,potassium ion transmembrane transporter activity;GO:0015379,potassium;GO:0019901,protein kinase binding	GO:0140157,ammonium import across plasma membrane;GO:0001525,angiogenesis;GO:0006884,cell volume homeostasis;GO:0071476,cellular hypotonic response;GO:0071477,cellular hypotonic salinity response;GO:0007268,chemical synaptic transmission;GO:0055064,chloride ion homeostasis;GO:1902476,chloride transmembrane transport;GO:0006811,ion transport;GO:0055075,potassium ion homeostasis;GO:1990573,potassium ion import across plasma membrane	
RPN1_HUMAN	P04843	RPN1	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	21.80001315	21.23788476	37.46022746	28.20774232	21.518948955	32.83398489	21.518948955	32.83398489	0.655386454830034	0.366406	0	1.52581731378525	0.366639	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0042470,melanosome;GO:0016020,membrane;GO:0008250,oligosaccharyltransferase complex;GO:0005791,rough endoplasmic reticulum	GO:0003723,RNA binding;GO:0016740,transferase activity	GO:0006464,cellular protein modification process;GO:0006487,protein N-linked glycosylation;GO:0018279,protein N-linked glycosylation via asparagine;GO:0019082,viral protein processing;GO:0006486,protein glycosylation	hsa:6184,path:hsa00510,N-Glycan biosynthesis;hsa:6184,path:hsa00513,Various types of N-glycan biosynthesis;hsa:6184,path:hsa04141,Protein processing in endoplasmic reticulum
G6PE_HUMAN	O95479	H6PD	GDH/6PGL endoplasmic bifunctional protein	0.772710486	1.820608396	1.905946773	2.685240787	1.296659441	2.29559378	1.296659441	2.29559378	0.564847078911322	0.284818	0	1.77039067268859	0.285117	0	GO:0005788,endoplasmic reticulum lumen;GO:0005739,mitochondrion	GO:0017057,6-phosphogluconolactonase activity;GO:0030246,carbohydrate binding;GO:0047934,glucose 1-dehydrogenase (NAD+) activity;GO:0047935,glucose 1-dehydrogenase (NADP+) activity;GO:0004345,glucose-6-phosphate dehydrogenase activity;GO:0050661,NADP binding	GO:0006006,glucose metabolic process;GO:0009051,pentose-phosphate shunt, oxidative branch;GO:2000064,regulation of cortisol biosynthetic process;GO:0097305,response to alcohol	hsa:9563,path:hsa00030,Pentose phosphate pathway
AHNK2_HUMAN	Q8IVF2	AHNAK2	Protein AHNAK2	0.08096805	0.450087243	0.126982587	0.112084481	0.2655276465	0.119533534	0.2655276465	0.119533534	2.22136531577825	0.200298	0	0.45017359049277	0.199738	0	GO:0043034,costamere;GO:0005737,cytoplasm;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0042383,sarcolemma;GO:0030315,T-tubule;GO:0030018,Z disc		GO:0043484,regulation of RNA splicing	hsa:113146,path:hsa05132,Salmonella infection
CO1A2_HUMAN	P08123	COL1A2	Collagen alpha-2(I) chain	4.766984221	32.07165732	5.968508633	29.87210954	18.4193207705	17.9203090865	18.4193207705	17.9203090865	1.02784615385769	0.424263	0	0.972908247257456	0.424047	0	GO:0005584,collagen type I trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0005201,extracellular matrix structural constituent;GO:0030020,extracellular matrix structural constituent conferring tensile strength;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0048407,platelet-derived growth factor binding;GO:0002020,protease binding;GO:0030674,protein-macromolecule adaptor activity;GO:0046332,SMAD binding	GO:0007596,blood coagulation;GO:0001568,blood vessel development;GO:0030282,bone mineralization;GO:0071230,cellular response to amino acid stimulus;GO:0030199,collagen fibril organization;GO:0032963,collagen metabolic process;GO:0019221,cytokine-mediated signaling pathway;GO:0085029,extracellular matrix assembly;GO:0030198,extracellular matrix organization;GO:0050900,leukocyte migration;GO:0042476,odontogenesis;GO:0030168,platelet activation;GO:0070208,protein heterotrimerization;GO:0008217,regulation of blood pressure;GO:0050776,regulation of immune response;GO:0007266,Rho protein signal transduction;GO:0001501,skeletal system development;GO:0043589,skin morphogenesis;GO:0007179,transforming growth factor beta receptor signaling pathway	hsa:1278,path:hsa04151,PI3K-Akt signaling pathway;hsa:1278,path:hsa04512,ECM-receptor interaction;hsa:1278,path:hsa04510,Focal adhesion;hsa:1278,path:hsa04611,Platelet activation;hsa:1278,path:hsa04926,Relaxin signaling pathway;hsa:1278,path:hsa04974,Protein digestion and absorption;hsa:1278,path:hsa05205,Proteoglycans in cancer;hsa:1278,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:1278,path:hsa05165,Human papillomavirus infection;hsa:1278,path:hsa05146,Amoebiasis
KAP2_HUMAN	P13861	PRKAR2A	cAMP-dependent protein kinase type II-alpha regulatory subunit	2.078848181	2.044154704	3.778670052	6.238128822	2.0615014425	5.008399437	2.0615014425	5.008399437	0.411608832009379	0.146345	0	2.42949111445989	0.146675	0	GO:0005952,cAMP-dependent protein kinase complex;GO:0005813,centrosome;GO:0097546,ciliary base;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0031588,nucleotide-activated protein kinase complex;GO:0005886,plasma membrane;GO:0044853,plasma membrane raft;GO:0032991,protein-containing complex;GO:0045202,synapse	GO:0030552,cAMP binding;GO:0004862,cAMP-dependent protein kinase inhibitor activity;GO:0008603,cAMP-dependent protein kinase regulator activity;GO:0019904,protein domain specific binding;GO:0034236,protein kinase A catalytic subunit binding;GO:0031625,ubiquitin protein ligase binding	GO:0034199,activation of protein kinase A activity;GO:0007596,blood coagulation;GO:0071377,cellular response to glucagon stimulus;GO:0007268,chemical synaptic transmission;GO:0035556,intracellular signal transduction;GO:2000480,negative regulation of cAMP-dependent protein kinase activity;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0043949,regulation of cAMP-mediated signaling;GO:0010738,regulation of protein kinase A signaling;GO:0003091,renal water homeostasis;GO:0007339,binding of sperm to zona pellucida	hsa:5576,path:hsa04910,Insulin signaling pathway
KGP1_HUMAN	Q13976	PRKG1	cGMP-dependent protein kinase 1	0.129927976	0.430953084	0.317307609	0.79851805	0.28044053	0.5579128295	0.28044053	0.5579128295	0.50266012031186	0.227580	0	1.98941582908861	0.227908	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0005886,plasma membrane	GO:0005524,ATP binding;GO:0005246,calcium channel regulator activity;GO:0030553,cGMP binding;GO:0004692,cGMP-dependent protein kinase activity;GO:0042802,identical protein binding;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0106311,protein threonine kinase activity	GO:0030036,actin cytoskeleton organization;GO:0002250,adaptive immune response;GO:0019934,cGMP-mediated signaling;GO:0016358,dendrite development;GO:0030900,forebrain development;GO:0090331,negative regulation of platelet aggregation;GO:1904753,negative regulation of vascular associated smooth muscle cell migration;GO:1904706,negative regulation of vascular associated smooth muscle cell proliferation;GO:0001764,neuron migration;GO:0006468,protein phosphorylation;GO:0043087,regulation of GTPase activity;GO:0060087,relaxation of vascular associated smooth muscle;GO:0007165,signal transduction	hsa:5592,path:hsa04022,cGMP-PKG signaling pathway;hsa:5592,path:hsa04540,Gap junction;hsa:5592,path:hsa04611,Platelet activation;hsa:5592,path:hsa04923,Regulation of lipolysis in adipocytes;hsa:5592,path:hsa04270,Vascular smooth muscle contraction;hsa:5592,path:hsa04970,Salivary secretion;hsa:5592,path:hsa04730,Long-term depression;hsa:5592,path:hsa04740,Olfactory transduction;hsa:5592,path:hsa04713,Circadian entrainment;hsa:5592,path:hsa04714,Thermogenesis
CD44_HUMAN	P16070	CD44	CD44 antigen	2.045383099	2.107027638	3.234054292	4.171312851	2.0762053685	3.7026835715	2.0762053685	3.7026835715	0.560729894523205	0.281036	0	1.78338984556961	0.281337	0	GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0042995,cell projection;GO:0009986,cell surface;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0031258,lamellipodium membrane;GO:0035692,macrophage migration inhibitory factor receptor complex;GO:0005902,microvillus;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0016021,integral component of membrane	GO:0005518,collagen binding;GO:0005540,hyaluronic acid binding;GO:0004888,transmembrane signaling receptor activity	GO:0051216,cartilage development;GO:0007155,cell adhesion;GO:0016477,cell migration;GO:0098609,cell-cell adhesion;GO:0007160,cell-matrix adhesion;GO:0044344,cellular response to fibroblast growth factor stimulus;GO:0022617,extracellular matrix disassembly;GO:0030198,extracellular matrix organization;GO:0030214,hyaluronan catabolic process;GO:0006954,inflammatory response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0050900,leukocyte migration;GO:0070487,monocyte aggregation;GO:0043066,negative regulation of apoptotic process;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043518,negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:1902166,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043312,neutrophil degranulation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0034116,positive regulation of heterotypic cell-cell adhesion;GO:1900625,positive regulation of monocyte aggregation;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:2000392,regulation of lamellipodium morphogenesis;GO:0042110,T cell activation;GO:0044319,wound healing, spreading of cells;GO:0033674,positive regulation of kinase activity	hsa:960,path:hsa04512,ECM-receptor interaction;hsa:960,path:hsa04640,Hematopoietic cell lineage;hsa:960,path:hsa05206,MicroRNAs in cancer;hsa:960,path:hsa05205,Proteoglycans in cancer;hsa:960,path:hsa05131,Shigellosis;hsa:960,path:hsa05169,Epstein-Barr virus infection
HS71B_HUMAN	P0DMV9	HSPA1B	Heat shock 70 kDa protein 1B	52.03886103	84.65145042	59.49185345	73.52304527	68.345155725	66.50744936	68.345155725	66.50744936	1.02763158687762	0.424332	0	0.973111388137085	0.424116	0	GO:0016235,aggresome;GO:0072562,blood microparticle;GO:0005814,centriole;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005925,focal adhesion;GO:0016234,inclusion body;GO:0005739,mitochondrion;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:1990904,ribonucleoprotein complex;GO:0031982,vesicle	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0055131,C3HC4-type RING finger domain binding;GO:0019899,enzyme binding;GO:0001664,G protein-coupled receptor binding;GO:0031072,heat shock protein binding;GO:0042826,histone deacetylase binding;GO:0051787,misfolded protein binding;GO:0044183,protein folding chaperone;GO:0047485,protein N-terminus binding;GO:0003723,RNA binding;GO:0005102,signaling receptor binding;GO:0031625,ubiquitin protein ligase binding;GO:0051082,unfolded protein binding;GO:0001618,virus receptor activity	GO:0046034,ATP metabolic process;GO:0070370,cellular heat acclimation;GO:0034605,cellular response to heat;GO:0034599,cellular response to oxidative stress;GO:0034620,cellular response to unfolded protein;GO:0051085,chaperone cofactor-dependent protein refolding;GO:0006402,mRNA catabolic process;GO:0043066,negative regulation of apoptotic process;GO:0060548,negative regulation of cell death;GO:0030308,negative regulation of cell growth;GO:0008285,negative regulation of cell population proliferation;GO:2001240,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0090084,negative regulation of inclusion body assembly;GO:0031397,negative regulation of protein ubiquitination;GO:0043312,neutrophil degranulation;GO:0045648,positive regulation of erythrocyte differentiation;GO:0010628,positive regulation of gene expression;GO:0032757,positive regulation of interleukin-8 production;GO:0090063,positive regulation of microtubule nucleation;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0070434,positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1903265,positive regulation of tumor necrosis factor-mediated signaling pathway;GO:0042026,protein refolding;GO:0050821,protein stabilization;GO:1900034,regulation of cellular response to heat;GO:1901673,regulation of mitotic spindle assembly;GO:0031396,regulation of protein ubiquitination;GO:0016192,vesicle-mediated transport	hsa:3303,path:hsa03040,Spliceosome;hsa:3303,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:3303,path:hsa04010,MAPK signaling pathway;hsa:3303,path:hsa04144,Endocytosis;hsa:3303,path:hsa04612,Antigen processing and presentation;hsa:3303,path:hsa04915,Estrogen signaling pathway;hsa:3303,path:hsa04213,Longevity regulating pathway - multiple species;hsa:3303,path:hsa05020,Prion diseases;hsa:3303,path:hsa05134,Legionellosis;hsa:3303,path:hsa05162,Measles;hsa:3303,path:hsa05145,Toxoplasmosis;hsa:3304,path:hsa03040,Spliceosome;hsa:3304,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:3304,path:hsa04010,MAPK signaling pathway;hsa:3304,path:hsa04144,Endocytosis;hsa:3304,path:hsa04612,Antigen processing and presentation;hsa:3304,path:hsa04915,Estrogen signaling pathway;hsa:3304,path:hsa04213,Longevity regulating pathway - multiple species;hsa:3304,path:hsa05134,Legionellosis;hsa:3304,path:hsa05162,Measles;hsa:3304,path:hsa05145,Toxoplasmosis
THOC4_HUMAN	Q86V81	ALYREF	THO complex subunit 4	1.032071164	3.424242673	0.395425842	0.421399871	2.2281569185	0.4084128565	2.2281569185	0.4084128565	5.45564832996387	0.055033	0	0.183296271958684	0.054623	0	GO:0071013,catalytic step 2 spliceosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000346,transcription export complex	GO:0062153,C5-methylcytidine-containing RNA binding;GO:0003723,RNA binding	GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0001649,osteoblast differentiation;GO:0032786,positive regulation of DNA-templated transcription, elongation;GO:0000018,regulation of DNA recombination;GO:0031297,replication fork processing;GO:0006405,RNA export from nucleus;GO:0046784,viral mRNA export from host cell nucleus;GO:0016032,viral process	hsa:10189,path:hsa03040,Spliceosome;hsa:10189,path:hsa03013,RNA transport;hsa:10189,path:hsa03015,mRNA surveillance pathway;hsa:10189,path:hsa05168,Herpes simplex virus 1 infection
VWF_HUMAN	P04275	VWF	von Willebrand factor	1.522512937	1.384812383	3.831268895	26.38383567	1.45366266	15.1075522825	1.45366266	15.1075522825	0.0962209253238108	0.000531	-1	10.3927497749031	0.000539	1	GO:0062023,collagen-containing extracellular matrix;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0031091,platelet alpha granule;GO:0031093,platelet alpha granule lumen;GO:0033093,Weibel-Palade body	GO:0051087,chaperone binding;GO:0005518,collagen binding;GO:0042802,identical protein binding;GO:0019865,immunoglobulin binding;GO:0005178,integrin binding;GO:0002020,protease binding;GO:0047485,protein N-terminus binding	GO:0007596,blood coagulation;GO:0007597,blood coagulation, intrinsic pathway;GO:0007155,cell adhesion;GO:0031589,cell-substrate adhesion;GO:0030198,extracellular matrix organization;GO:0007599,hemostasis;GO:0030168,platelet activation;GO:0002576,platelet degranulation;GO:0009611,response to wounding	hsa:7450,path:hsa04151,PI3K-Akt signaling pathway;hsa:7450,path:hsa04512,ECM-receptor interaction;hsa:7450,path:hsa04510,Focal adhesion;hsa:7450,path:hsa04610,Complement and coagulation cascades;hsa:7450,path:hsa04611,Platelet activation;hsa:7450,path:hsa05165,Human papillomavirus infection
RBGP1_HUMAN	Q9Y3P9	RABGAP1	Rab GTPase-activating protein 1	0.050388416	0.02338839	0.200293592	2.55E-05	0.036888403	0.100159546	0.036888403	0.100159546	0.368296427781332	0.110825	0	2.71520417948156	0.111133	0	GO:0005813,centrosome;GO:0005829,cytosol;GO:0005875,microtubule associated complex;GO:0016021,integral component of membrane	GO:0005096,GTPase activator activity;GO:0031267,small GTPase binding;GO:0015631,tubulin binding;GO:0004930,G protein-coupled receptor activity	GO:0090630,activation of GTPase activity;GO:0007049,cell cycle;GO:0006886,intracellular protein transport;GO:0043087,regulation of GTPase activity;GO:0042593,glucose homeostasis;GO:0046627,negative regulation of insulin receptor signaling pathway;GO:0040018,positive regulation of multicellular organism growth	
TMTC3_HUMAN	Q6ZXV5	TMTC3	Protein O-mannosyl-transferase TMTC3	0.369381304	0.360310674	0.588618164	1.633152075	0.364845989	1.1108851195	0.364845989	1.1108851195	0.328428189914196	0.081170	0	3.04480562481941	0.081446	0	GO:0005783,endoplasmic reticulum;GO:0016021,integral component of membrane	GO:0004169,dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0000030,mannosyltransferase activity	GO:1901800,positive regulation of proteasomal protein catabolic process;GO:0035269,protein O-linked mannosylation;GO:0034976,response to endoplasmic reticulum stress	
PLOD2_HUMAN	O00469	PLOD2	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	0.611380066	0.176799854	0.286941109	0.143587097	0.39408996	0.215264103	0.39408996	0.215264103	1.83072771775608	0.249032	0	0.546230873275736	0.248513	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0030867,rough endoplasmic reticulum membrane	GO:0005506,iron ion binding;GO:0031418,L-ascorbic acid binding;GO:0008475,procollagen-lysine 5-dioxygenase activity	GO:0006464,cellular protein modification process;GO:0030199,collagen fibril organization;GO:0046947,hydroxylysine biosynthetic process;GO:0017185,peptidyl-lysine hydroxylation;GO:0001666,response to hypoxia	hsa:5352,path:hsa00310,Lysine degradation
LDHA_HUMAN	P00338	LDHA	L-lactate dehydrogenase A chain	61.98851714	107.3367818	53.585796	34.10641036	84.66264947	43.84610318	84.66264947	43.84610318	1.93090476301707	0.235011	0	0.517891932918267	0.234477	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005634,nucleus;GO:0016021,integral component of membrane	GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0019900,kinase binding;GO:0004459,L-lactate dehydrogenase activity;GO:0051287,NAD binding;GO:0016616,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO:0006096,glycolytic process;GO:0006089,lactate metabolic process;GO:0019674,NAD metabolic process;GO:0043065,positive regulation of apoptotic process;GO:0048569,post-embryonic animal organ development;GO:0006090,pyruvate metabolic process;GO:0051591,response to cAMP;GO:0042493,response to drug;GO:0043627,response to estrogen;GO:0009749,response to glucose;GO:0042542,response to hydrogen peroxide;GO:0001666,response to hypoxia;GO:0007584,response to nutrient;GO:0021762,substantia nigra development;GO:0019752,carboxylic acid metabolic process	hsa:3939,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:3939,path:hsa00620,Pyruvate metabolism;hsa:3939,path:hsa00640,Propanoate metabolism;hsa:3939,path:hsa00270,Cysteine and methionine metabolism;hsa:3939,path:hsa04066,HIF-1 signaling pathway;hsa:3939,path:hsa04922,Glucagon signaling pathway;hsa:3939,path:hsa05230,Central carbon metabolism in cancer
NCBP1_HUMAN	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.499894753	0.344576137	0.746878139	0.784826432	0.422235445	0.7658522855	0.422235445	0.7658522855	0.551327524895139	0.272387	0	1.81380387309739	0.272694	0	GO:0005829,cytosol;GO:0005739,mitochondrion;GO:0005845,mRNA cap binding complex;GO:0005846,nuclear cap binding complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0034518,RNA cap binding complex	GO:0003729,mRNA binding;GO:0000340,RNA 7-methylguanosine cap binding;GO:0003723,RNA binding;GO:0000339,RNA cap binding	GO:0006370,7-methylguanosine mRNA capping;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0031047,gene silencing by RNA;GO:0008334,histone mRNA metabolic process;GO:0031124,mRNA 3'-end processing;GO:0045292,mRNA cis splicing, via spliceosome;GO:0006406,mRNA export from nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0051168,nuclear export;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0030307,positive regulation of cell growth;GO:0031442,positive regulation of mRNA 3'-end processing;GO:0048026,positive regulation of mRNA splicing, via spliceosome;GO:1905216,positive regulation of RNA binding;GO:0098789,pre-mRNA cleavage required for polyadenylation;GO:0050684,regulation of mRNA processing;GO:0006446,regulation of translational initiation;GO:0006401,RNA catabolic process;GO:0006405,RNA export from nucleus;GO:0016070,RNA metabolic process;GO:0008380,RNA splicing;GO:0042795,snRNA transcription by RNA polymerase II;GO:0000245,spliceosomal complex assembly;GO:0006369,termination of RNA polymerase II transcription;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter;GO:0051028,mRNA transport	hsa:4686,path:hsa03040,Spliceosome;hsa:4686,path:hsa03013,RNA transport;hsa:4686,path:hsa03015,mRNA surveillance pathway
ADPRS_HUMAN	Q9NX46	ADPRS	ADP-ribose glycohydrolase ARH3	0.459132574	0.375294656	0.854241269	0.433102312	0.417213615	0.6436717905	0.417213615	0.6436717905	0.648177566824719	0.360063	0	1.54278711757765	0.360302	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0090734,site of DNA damage	GO:0140292,ADP-ribosylserine hydrolase activity;GO:0004553,hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0000287,magnesium ion binding;GO:0061463,O-acetyl-ADP-ribose deacetylase activity;GO:0004649,poly(ADP-ribose) glycohydrolase activity	GO:0006287,base-excision repair, gap-filling;GO:0071451,cellular response to superoxide;GO:0006281,DNA repair;GO:0140290,peptidyl-serine ADP-deribosylation	
SCRB2_HUMAN	Q14108	SCARB2	Lysosome membrane protein 2	1.947102839	2.256741739	3.275262756	3.312490194	2.101922289	3.293876475	2.101922289	3.293876475	0.638130271415233	0.351170	0	1.5670781418694	0.351417	0	GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0005737,cytoplasm;GO:0030666,endocytic vesicle membrane;GO:0005789,endoplasmic reticulum membrane;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0031902,late endosome membrane;GO:0043202,lysosomal lumen;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0005764,lysosome	GO:0038024,cargo receptor activity;GO:0015485,cholesterol binding;GO:0019899,enzyme binding;GO:0031210,phosphatidylcholine binding;GO:0001786,phosphatidylserine binding;GO:0042803,protein homodimerization activity;GO:0005044,scavenger receptor activity;GO:0004888,transmembrane signaling receptor activity;GO:0001618,virus receptor activity;GO:0051087,chaperone binding	GO:0015917,aminophospholipid transport;GO:0061024,membrane organization;GO:0010976,positive regulation of neuron projection development;GO:0006622,protein targeting to lysosome;GO:0006898,receptor-mediated endocytosis;GO:0043471,regulation of cellular carbohydrate catabolic process;GO:1904978,regulation of endosome organization;GO:1905123,regulation of glucosylceramidase activity;GO:1905671,regulation of lysosome organization	hsa:950,path:hsa04142,Lysosome
SMYD5_HUMAN	Q6GMV2	SMYD5	SET and MYND domain-containing protein 5	0.015106932	0.065590796	0.046125923	0.101340453	0.040348864	0.073733188	0.040348864	0.073733188	0.547227986398743	0.268612	0	1.82739191864237	0.268921	0		GO:0018024,histone-lysine N-methyltransferase activity;GO:0046872,metal ion binding		
DIRA2_HUMAN	Q96HU8	DIRAS2	GTP-binding protein Di-Ras2	8.877239315	18.36692083	13.58964887	47.61773806	13.6220800725	30.603693465	13.6220800725	30.603693465	0.445112289733229	0.175500	0	2.24662410601903	0.175836	0	GO:0005886,plasma membrane;GO:0016020,membrane	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0007165,signal transduction	
PREB_HUMAN	Q9HCU5	PREB	Prolactin regulatory element-binding protein	0.579414201	0.277542185	0.725481432	0.058754787	0.428478193	0.3921181095	0.428478193	0.3921181095	1.09272737631619	0.404161	0	0.915141344194382	0.403903	0	GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016020,membrane;GO:0005634,nucleus;GO:0016021,integral component of membrane	GO:0003677,DNA binding;GO:0005096,GTPase activator activity;GO:0051020,GTPase binding;GO:0005085,guanyl-nucleotide exchange factor activity	GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0036498,IRE1-mediated unfolded protein response;GO:0032527,protein exit from endoplasmic reticulum;GO:0009306,protein secretion;GO:0003400,regulation of COPII vesicle coating	hsa:10113,path:hsa04141,Protein processing in endoplasmic reticulum
ODO1_HUMAN	Q02218	OGDH	2-oxoglutarate dehydrogenase, mitochondrial	10.16796071	5.490982158	10.00652622	10.3820877	7.829471434	10.19430696	7.829471434	10.19430696	0.768023904393006	0.460562	0	1.30204280658469	0.460697	0	GO:0005759,mitochondrial matrix;GO:0031966,mitochondrial membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0045252,oxoglutarate dehydrogenase complex	GO:0046872,metal ion binding;GO:0004591,oxoglutarate dehydrogenase (succinyl-transferring) activity;GO:0030976,thiamine pyrophosphate binding;GO:0051087,chaperone binding;GO:0031072,heat shock protein binding;GO:0034602,oxoglutarate dehydrogenase (NAD+) activity	GO:0006103,2-oxoglutarate metabolic process;GO:0006091,generation of precursor metabolites and energy;GO:0006096,glycolytic process;GO:0106077,histone succinylation;GO:0006554,lysine catabolic process;GO:0006104,succinyl-CoA metabolic process;GO:0006099,tricarboxylic acid cycle;GO:0021695,cerebellar cortex development;GO:0021766,hippocampus development;GO:0006734,NADH metabolic process;GO:0061034,olfactory bulb mitral cell layer development;GO:0021860,pyramidal neuron development;GO:0021756,striatum development;GO:0022028,tangential migration from the subventricular zone to the olfactory bulb;GO:0021794,thalamus development	hsa:4967,path:hsa00020,Citrate cycle (TCA cycle)
ACTA_HUMAN	P62736	ACTA2	Actin, aortic smooth muscle	122.8411752	109.0120835	125.573292	260.7151546	115.92662935	193.1442233	115.92662935	193.1442233	0.600207592902935	0.317111	0	1.66609021915809	0.317387	0	GO:0044297,cell body;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005869,dynactin complex;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0030175,filopodium;GO:0030027,lamellipodium;GO:0032991,protein-containing complex;GO:0030485,smooth muscle contractile fiber	GO:0005524,ATP binding;GO:0019901,protein kinase binding	GO:0072144,glomerular mesangial cell development;GO:0090131,mesenchyme migration;GO:0006936,muscle contraction;GO:0010628,positive regulation of gene expression;GO:0045893,positive regulation of transcription, DNA-templated;GO:0008217,regulation of blood pressure;GO:0009615,response to virus;GO:0014829,vascular associated smooth muscle contraction	hsa:59,path:hsa04371,Apelin signaling pathway;hsa:59,path:hsa04926,Relaxin signaling pathway;hsa:59,path:hsa04270,Vascular smooth muscle contraction
FCERG_HUMAN	P30273	FCER1G	High affinity immunoglobulin epsilon receptor subunit gamma	0.347528652	0.750552636	0.272380732	0.146163597	0.549040644	0.2092721645	0.549040644	0.2092721645	2.62357225248655	0.163340	0	0.381159695164571	0.162770	0	GO:0009986,cell surface;GO:0009897,external side of plasma membrane;GO:0032998,Fc-epsilon receptor I complex;GO:0101003,ficolin-1-rich granule membrane;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane;GO:0070821,tertiary granule membrane;GO:0016021,integral component of membrane	GO:0042802,identical protein binding;GO:0019863,IgE binding;GO:0019767,IgE receptor activity;GO:0019864,IgG binding	GO:0042590,antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0007596,blood coagulation;GO:0071404,cellular response to low-density lipoprotein particle stimulus;GO:0042742,defense response to bacterium;GO:0002431,Fc receptor mediated stimulatory signaling pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038094,Fc-gamma receptor signaling pathway;GO:0016064,immunoglobulin mediated immune response;GO:0045087,innate immune response;GO:0038156,interleukin-3-mediated signaling pathway;GO:0050900,leukocyte migration;GO:0002283,neutrophil activation involved in immune response;GO:0030593,neutrophil chemotaxis;GO:0043312,neutrophil degranulation;GO:0030168,platelet activation;GO:0032753,positive regulation of interleukin-4 production;GO:0050766,positive regulation of phagocytosis;GO:0031623,receptor internalization;GO:0010543,regulation of platelet activation;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0002292,T cell differentiation involved in immune response	hsa:2207,path:hsa04072,Phospholipase D signaling pathway;hsa:2207,path:hsa04071,Sphingolipid signaling pathway;hsa:2207,path:hsa04611,Platelet activation;hsa:2207,path:hsa04625,C-type lectin receptor signaling pathway;hsa:2207,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:2207,path:hsa04664,Fc epsilon RI signaling pathway;hsa:2207,path:hsa05310,Asthma;hsa:2207,path:hsa05152,Tuberculosis
C2D1A_HUMAN	Q6P1N0	CC2D1A	Coiled-coil and C2 domain-containing protein 1A	0.186107348	0.159807147	0.20752445	0.214048282	0.1729572475	0.210786366	0.1729572475	0.210786366	0.820533371214341	0.499549	0	1.2187194757479	0.499498	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0001650,fibrillar center;GO:0016020,membrane;GO:0005815,microtubule organizing center;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0045296,cadherin binding;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227,DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:1905381,negative regulation of snRNA transcription by RNA polymerase II;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0006357,regulation of transcription by RNA polymerase II	
SORCN_HUMAN	P30626	SRI	Sorcin	4.924201769	12.21458599	0.824200679	3.395272732	8.5693938795	2.1097367055	8.5693938795	2.1097367055	4.06183096552282	0.088631	0	0.246194390777974	0.088128	0	GO:0043679,axon terminus;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0044326,dendritic spine neck;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0016529,sarcoplasmic reticulum;GO:0033017,sarcoplasmic reticulum membrane;GO:0005790,smooth endoplasmic reticulum;GO:0030315,T-tubule;GO:0030018,Z disc	GO:0005246,calcium channel regulator activity;GO:0005509,calcium ion binding;GO:0042802,identical protein binding;GO:0044325,ion channel binding;GO:0002020,protease binding;GO:0046982,protein heterodimerization activity;GO:0070491,repressing transcription factor binding;GO:0005102,signaling receptor binding	GO:0001508,action potential;GO:0006816,calcium ion transport;GO:0042994,cytoplasmic sequestering of transcription factor;GO:0007507,heart development;GO:0006880,intracellular sequestering of iron ion;GO:0007517,muscle organ development;GO:0055118,negative regulation of cardiac muscle contraction;GO:0010459,negative regulation of heart rate;GO:0060315,negative regulation of ryanodine-sensitive calcium-release channel activity;GO:2000678,negative regulation of transcription regulatory region DNA binding;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0051281,positive regulation of release of sequestered calcium ion into cytosol;GO:0051924,regulation of calcium ion transport;GO:0086004,regulation of cardiac muscle cell contraction;GO:0010649,regulation of cell communication by electrical coupling;GO:1901844,regulation of cell communication by electrical coupling involved in cardiac conduction;GO:0008016,regulation of heart contraction;GO:1901841,regulation of high voltage-gated calcium channel activity;GO:1901077,regulation of relaxation of muscle;GO:0010880,regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0006942,regulation of striated muscle contraction;GO:0007165,signal transduction	
PCP_HUMAN	P42785	PRCP	Lysosomal Pro-X carboxypeptidase	0.276936129	0.327995582	0.793602317	1.092826293	0.3024658555	0.943214305	0.3024658555	0.943214305	0.320675644863126	0.075822	0	3.11841580743318	0.076090	0	GO:0035577,azurophil granule membrane;GO:0045178,basal part of cell;GO:0070062,extracellular exosome;GO:0101003,ficolin-1-rich granule membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005886,plasma membrane	GO:0008239,dipeptidyl-peptidase activity;GO:0004185,serine-type carboxypeptidase activity;GO:0004180,carboxypeptidase activity;GO:0008236,serine-type peptidase activity	GO:0060055,angiogenesis involved in wound healing;GO:0007597,blood coagulation, intrinsic pathway;GO:0097009,energy homeostasis;GO:0042593,glucose homeostasis;GO:0003085,negative regulation of systemic arterial blood pressure;GO:0043312,neutrophil degranulation;GO:0002353,plasma kallikrein-kinin cascade;GO:0006508,proteolysis;GO:0043535,regulation of blood vessel endothelial cell migration;GO:2000377,regulation of reactive oxygen species metabolic process;GO:0002155,regulation of thyroid hormone mediated signaling pathway	hsa:5547,path:hsa04614,Renin-angiotensin system;hsa:5547,path:hsa04974,Protein digestion and absorption
H2AY_HUMAN	O75367	MACROH2A1	Core histone macro-H2A.1	3.809771368	23.90074675	2.969220161	2.079371412	13.855259059	2.5242957865	13.855259059	2.5242957865	5.4887621066827	0.054468	0	0.182190443047709	0.054060	0	GO:0001740,Barr body;GO:0000785,chromatin;GO:0000781,chromosome, telomeric region;GO:0000793,condensed chromosome;GO:0070062,extracellular exosome;GO:0000228,nuclear chromosome;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0000786,nucleosome;GO:0005634,nucleus;GO:0005721,pericentric heterochromatin;GO:0001739,sex chromatin	GO:0031490,chromatin DNA binding;GO:0003677,DNA binding;GO:0010385,double-stranded methylated DNA binding;GO:0019899,enzyme binding;GO:0031492,nucleosomal DNA binding;GO:1990841,promoter-specific chromatin binding;GO:0046982,protein heterodimerization activity;GO:0019901,protein kinase binding;GO:0030291,protein serine/threonine kinase inhibitor activity;GO:0000182,rDNA binding;GO:0000979,RNA polymerase II core promoter sequence-specific DNA binding;GO:0000977,RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976,transcription regulatory region sequence-specific DNA binding	GO:0006342,chromatin silencing;GO:0007549,dosage compensation;GO:0071169,establishment of protein localization to chromatin;GO:1902750,negative regulation of cell cycle G2/M phase transition;GO:0045814,negative regulation of gene expression, epigenetic;GO:0061086,negative regulation of histone H3-K27 methylation;GO:0051572,negative regulation of histone H3-K4 methylation;GO:0033128,negative regulation of histone phosphorylation;GO:1904815,negative regulation of protein localization to chromosome, telomeric region;GO:0071901,negative regulation of protein serine/threonine kinase activity;GO:1902883,negative regulation of response to oxidative stress;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:1901837,negative regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0006334,nucleosome assembly;GO:1903226,positive regulation of endodermal cell differentiation;GO:0045815,positive regulation of gene expression, epigenetic;GO:0045618,positive regulation of keratinocyte differentiation;GO:0034184,positive regulation of maintenance of mitotic sister chromatid cohesion;GO:1902884,positive regulation of response to oxidative stress;GO:0040029,regulation of gene expression, epigenetic;GO:0019216,regulation of lipid metabolic process;GO:1902882,regulation of response to oxidative stress	hsa:9555,path:hsa04217,Necroptosis;hsa:9555,path:hsa05322,Systemic lupus erythematosus;hsa:9555,path:hsa05034,Alcoholism
UBE2O_HUMAN	Q9C0C9	UBE2O	(E3-independent) E2 ubiquitin-conjugating enzyme	0.271041648	0.115513699	0.336633766	0.359796884	0.1932776735	0.348215325	0.1932776735	0.348215325	0.555052174972483	0.275815	0	1.80163243221158	0.276119	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0004869,cysteine-type endopeptidase inhibitor activity;GO:0003723,RNA binding;GO:0061631,ubiquitin conjugating enzyme activity;GO:0061630,ubiquitin protein ligase activity;GO:0004842,ubiquitin-protein transferase activity	GO:0043066,negative regulation of apoptotic process;GO:0030513,positive regulation of BMP signaling pathway;GO:0070534,protein K63-linked ubiquitination;GO:0006513,protein monoubiquitination;GO:0042147,retrograde transport, endosome to Golgi	hsa:63893,path:hsa04120,Ubiquitin mediated proteolysis
CPSF3_HUMAN	Q9UKF6	CPSF3	Cleavage and polyadenylation specificity factor subunit 3	0.133930938	0.097305736	0.160296284	0.154947907	0.115618337	0.1576220955	0.115618337	0.1576220955	0.733516050736681	0.432791	0	1.36329668450429	0.432957	0	GO:0005847,mRNA cleavage and polyadenylation specificity factor complex;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0008409,5'-3' exonuclease activity;GO:0004521,endoribonuclease activity;GO:0046872,metal ion binding;GO:0003723,RNA binding	GO:0031124,mRNA 3'-end processing;GO:0006398,mRNA 3'-end processing by stem-loop binding and cleavage;GO:0006379,mRNA cleavage;GO:0006406,mRNA export from nucleus;GO:0006378,mRNA polyadenylation;GO:0000398,mRNA splicing, via spliceosome;GO:0006369,termination of RNA polymerase II transcription;GO:0006397,mRNA processing	hsa:51692,path:hsa03015,mRNA surveillance pathway
KDM1A_HUMAN	O60341	KDM1A	Lysine-specific histone demethylase 1A	0.245933893	0.081399722	0.287676859	0.105437459	0.1636668075	0.196557159	0.1636668075	0.196557159	0.832667750860196	0.494613	0	1.20095920487726	0.494551	0	GO:0000785,chromatin;GO:0000781,chromosome, telomeric region;GO:1990391,DNA repair complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0005667,transcription regulator complex	GO:0050681,androgen receptor binding;GO:0003682,chromatin binding;GO:0032451,demethylase activity;GO:0019899,enzyme binding;GO:0050660,flavin adenine dinucleotide binding;GO:0032452,histone demethylase activity;GO:0034648,histone demethylase activity (H3-dimethyl-K4 specific);GO:0032453,histone demethylase activity (H3-K4 specific);GO:0032454,histone demethylase activity (H3-K9 specific);GO:0043426,MRF binding;GO:0030374,nuclear receptor coactivator activity;GO:0016491,oxidoreductase activity;GO:0002039,p53 binding;GO:1990841,promoter-specific chromatin binding;GO:0001085,RNA polymerase II transcription factor binding;GO:0061752,telomeric repeat-containing RNA binding;GO:0008134,transcription factor binding	GO:0000380,alternative mRNA splicing, via spliceosome;GO:0007596,blood coagulation;GO:0071320,cellular response to cAMP;GO:0071480,cellular response to gamma radiation;GO:0034644,cellular response to UV;GO:0021987,cerebral cortex development;GO:0046098,guanine metabolic process;GO:0034720,histone H3-K4 demethylation;GO:0033169,histone H3-K9 demethylation;GO:0030522,intracellular receptor signaling pathway;GO:0055001,muscle cell development;GO:0043392,negative regulation of DNA binding;GO:0043518,negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0043433,negative regulation of DNA-binding transcription factor activity;GO:0051572,negative regulation of histone H3-K4 methylation;GO:0051573,negative regulation of histone H3-K9 methylation;GO:1902166,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0032091,negative regulation of protein binding;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0042551,neuron maturation;GO:0045793,positive regulation of cell size;GO:0035563,positive regulation of chromatin binding;GO:0120162,positive regulation of cold-induced thermogenesis;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0033184,positive regulation of histone ubiquitination;GO:2000179,positive regulation of neural precursor cell proliferation;GO:0002052,positive regulation of neuroblast proliferation;GO:0010976,positive regulation of neuron projection development;GO:2000648,positive regulation of stem cell proliferation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0006482,protein demethylation;GO:0060765,regulation of androgen receptor signaling pathway;GO:1903827,regulation of cellular protein localization;GO:0010569,regulation of double-strand break repair via homologous recombination;GO:0006357,regulation of transcription by RNA polymerase II;GO:0060992,response to fungicide;GO:0006355,regulation of transcription, DNA-templated	hsa:23028,path:hsa04714,Thermogenesis
MRC1_HUMAN	P22897	MRC1	Macrophage mannose receptor 1	1.240562591	6.174504808	3.586408785	5.156217922	3.7075336995	4.3713133535	3.7075336995	4.3713133535	0.848150978820009	0.488420	0	1.1790353663109	0.488344	0	GO:0009986,cell surface;GO:0010008,endosome membrane;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane	GO:0038024,cargo receptor activity;GO:0005537,mannose binding;GO:0038023,signaling receptor activity;GO:0004888,transmembrane signaling receptor activity;GO:0001618,virus receptor activity	GO:0071346,cellular response to interferon-gamma;GO:0071353,cellular response to interleukin-4;GO:0071222,cellular response to lipopolysaccharide;GO:0052031,modulation by symbiont of host defense response;GO:0006898,receptor-mediated endocytosis	hsa:4360,path:hsa04145,Phagosome;hsa:4360,path:hsa05152,Tuberculosis
3HIDH_HUMAN	P31937	HIBADH	3-hydroxyisobutyrate dehydrogenase, mitochondrial	0.16806195	0.660664584	0.482172186	1.186446991	0.414363267	0.8343095885	0.414363267	0.8343095885	0.496654087057756	0.222074	0	2.01347381620099	0.222403	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0008442,3-hydroxyisobutyrate dehydrogenase activity;GO:0051287,NAD binding;GO:0050661,NADP binding;GO:0016616,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO:0009083,branched-chain amino acid catabolic process;GO:0006574,valine catabolic process	hsa:11112,path:hsa00280,Valine, leucine and isoleucine degradation
PURB_HUMAN	Q96QR8	PURB	Transcriptional activator protein Pur-beta	0.237072555	0.128241433	0.20626624	0.121919062	0.182656994	0.164092651	0.182656994	0.164092651	1.11313329930906	0.398132	0	0.898365003203765	0.397861	0	GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227,DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003729,mRNA binding;GO:0032422,purine-rich negative regulatory element binding;GO:0003723,RNA binding;GO:0000977,RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0003697,single-stranded DNA binding;GO:0046332,SMAD binding;GO:0008134,transcription factor binding	GO:0030154,cell differentiation;GO:0008283,cell population proliferation;GO:0045637,regulation of myeloid cell differentiation;GO:0006357,regulation of transcription by RNA polymerase II	
HNRPL_HUMAN	P14866	HNRNPL	Heterogeneous nuclear ribonucleoprotein L	6.791846869	3.570243507	8.530838918	10.32823099	5.181045188	9.429534954	5.181045188	9.429534954	0.549448643360954	0.270657	0	1.82000631375308	0.270965	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0035770,ribonucleoprotein granule	GO:0003729,mRNA binding;GO:0097157,pre-mRNA intronic binding;GO:0003723,RNA binding;GO:0000976,transcription regulatory region sequence-specific DNA binding	GO:0000398,mRNA splicing, via spliceosome;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0043484,regulation of RNA splicing;GO:0016070,RNA metabolic process;GO:0006396,RNA processing;GO:0006397,mRNA processing	
DAB2_HUMAN	P98082	DAB2	Disabled homolog 2	0.255987192	0.281063223	0.428673631	0.566372235	0.2685252075	0.497522933	0.2685252075	0.497522933	0.539724281413175	0.261699	0	1.85279787187205	0.262012	0	GO:0005905,clathrin-coated pit;GO:0030136,clathrin-coated vesicle;GO:0030665,clathrin-coated vesicle membrane;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0001650,fibrillar center;GO:0005925,focal adhesion;GO:0043231,intracellular membrane-bounded organelle;GO:0005765,lysosomal membrane;GO:0005886,plasma membrane	GO:0038024,cargo receptor activity;GO:0035615,clathrin adaptor activity;GO:0008022,protein C-terminus binding;GO:0046332,SMAD binding	GO:0006915,apoptotic process;GO:0035026,leading edge cell differentiation;GO:0061024,membrane organization;GO:0007275,multicellular organism development;GO:0060766,negative regulation of androgen receptor signaling pathway;GO:0043066,negative regulation of apoptotic process;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0032091,negative regulation of protein binding;GO:1903077,negative regulation of protein localization to plasma membrane;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0030335,positive regulation of cell migration;GO:2000370,positive regulation of clathrin-dependent endocytosis;GO:2000643,positive regulation of early endosome to late endosome transport;GO:0045807,positive regulation of endocytosis;GO:0010718,positive regulation of epithelial to mesenchymal transition;GO:0010862,positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0001934,positive regulation of protein phosphorylation;GO:0060391,positive regulation of SMAD protein signal transduction;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0030511,positive regulation of transforming growth factor beta receptor signaling pathway;GO:2000096,positive regulation of Wnt signaling pathway, planar cell polarity pathway;GO:0015031,protein transport;GO:0006898,receptor-mediated endocytosis;GO:0016055,Wnt signaling pathway	hsa:1601,path:hsa04144,Endocytosis
CLIC2_HUMAN	O15247	CLIC2	Chloride intracellular channel protein 2	0.169993898	0.471114187	0.52851449	0.837828883	0.3205540425	0.6831716865	0.3205540425	0.6831716865	0.469214472488242	0.197089	0	2.131221559934	0.197424	0	GO:0034707,chloride channel complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0005254,chloride channel activity;GO:0004602,glutathione peroxidase activity;GO:0005244,voltage-gated ion channel activity	GO:1902476,chloride transmembrane transport;GO:0006749,glutathione metabolic process;GO:0060315,negative regulation of ryanodine-sensitive calcium-release channel activity;GO:0051099,positive regulation of binding;GO:0010881,regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0010880,regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0007165,signal transduction	
HD_HUMAN	P42858	HTT	Huntingtin	0.160555983	0.303654719	0.481751442	0.210892912	0.232105351	0.346322177	0.232105351	0.346322177	0.670200658273178	0.379335	0	1.4920904473245	0.379556	0	GO:0005776,autophagosome;GO:0030424,axon;GO:0005814,centriole;GO:0005737,cytoplasm;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0030425,dendrite;GO:0005769,early endosome;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0016234,inclusion body;GO:0005770,late endosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0099524,postsynaptic cytosol;GO:0099523,presynaptic cytosol;GO:0032991,protein-containing complex	GO:0048487,beta-tubulin binding;GO:0034452,dynactin binding;GO:0045505,dynein intermediate chain binding;GO:0031072,heat shock protein binding;GO:0042802,identical protein binding;GO:0044325,ion channel binding;GO:0019900,kinase binding;GO:0002039,p53 binding;GO:0005522,profilin binding	GO:0006915,apoptotic process;GO:0000132,establishment of mitotic spindle orientation;GO:0007030,Golgi organization;GO:0099111,microtubule-based transport;GO:2001237,negative regulation of extrinsic apoptotic signaling pathway;GO:1905337,positive regulation of aggrephagy;GO:0043065,positive regulation of apoptotic process;GO:1903599,positive regulation of autophagy of mitochondrion;GO:0045724,positive regulation of cilium assembly;GO:0031587,positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:1904504,positive regulation of lipophagy;GO:0031648,protein destabilization;GO:1905289,regulation of CAMKK-AMPK signaling cascade;GO:2000479,regulation of cAMP-dependent protein kinase activity;GO:0043666,regulation of phosphoprotein phosphatase activity;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0047496,vesicle transport along microtubule;GO:0042297,vocal learning	hsa:3064,path:hsa05016,Huntington disease
NSF_HUMAN	P46459	NSF	Vesicle-fusing ATPase	5.808202955	4.485272064	7.209184542	5.981250951	5.1467375095	6.5952177465	5.1467375095	6.5952177465	0.780374160084602	0.470251	0	1.28143658663889	0.470375	0	GO:0005829,cytosol;GO:0043198,dendritic shaft;GO:0005794,Golgi apparatus;GO:0005795,Golgi stack;GO:0005765,lysosomal membrane;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0005737,cytoplasm	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0035255,ionotropic glutamate receptor binding;GO:0046872,metal ion binding;GO:0030165,PDZ domain binding;GO:0019901,protein kinase binding;GO:0044877,protein-containing complex binding;GO:0000149,SNARE binding;GO:0017075,syntaxin-1 binding;GO:0016787,hydrolase activity	GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006887,exocytosis;GO:0043001,Golgi to plasma membrane protein transport;GO:0048211,Golgi vesicle docking;GO:0006891,intra-Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0045026,plasma membrane fusion;GO:0045732,positive regulation of protein catabolic process;GO:0001921,positive regulation of receptor recycling;GO:0006813,potassium ion transport;GO:0017157,regulation of exocytosis;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0035494,SNARE complex disassembly;GO:0016192,vesicle-mediated transport;GO:0015031,protein transport	hsa:4905,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:4905,path:hsa04727,GABAergic synapse;hsa:4905,path:hsa04721,Synaptic vesicle cycle
BAG3_HUMAN	O95817	BAG3	BAG family molecular chaperone regulator 3	0.37982014	0.280866076	0.352103981	0.391990506	0.330343108	0.3720472435	0.330343108	0.3720472435	0.887906344614538	0.473036	0	1.12624490867235	0.472925	0	GO:0016235,aggresome;GO:0101031,chaperone complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0043005,neuron projection;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0001725,stress fiber;GO:0030018,Z disc	GO:0000774,adenyl-nucleotide exchange factor activity;GO:0045296,cadherin binding;GO:0051087,chaperone binding;GO:0045505,dynein intermediate chain binding;GO:0031072,heat shock protein binding;GO:0044877,protein-containing complex binding	GO:0070842,aggresome assembly;GO:0000045,autophagosome assembly;GO:0007420,brain development;GO:0034605,cellular response to heat;GO:0071260,cellular response to mechanical stimulus;GO:0034620,cellular response to unfolded protein;GO:0061684,chaperone-mediated autophagy;GO:0072321,chaperone-mediated protein transport;GO:0097192,extrinsic apoptotic signaling pathway in absence of ligand;GO:0008625,extrinsic apoptotic signaling pathway via death domain receptors;GO:0046716,muscle cell cellular homeostasis;GO:0043066,negative regulation of apoptotic process;GO:1903215,negative regulation of protein targeting to mitochondrion;GO:0010664,negative regulation of striated muscle cell apoptotic process;GO:0097201,negative regulation of transcription from RNA polymerase II promoter in response to stress;GO:1905337,positive regulation of aggrephagy;GO:0046827,positive regulation of protein export from nucleus;GO:0042307,positive regulation of protein import into nucleus;GO:0006457,protein folding;GO:0050821,protein stabilization;GO:0098840,protein transport along microtubule;GO:1900034,regulation of cellular response to heat;GO:0021510,spinal cord development	
SUSD2_HUMAN	Q9UGT4	SUSD2	Sushi domain-containing protein 2	0.091704815	0.106667348	0.769859692	2.990639903	0.0991860815	1.8802497975	0.0991860815	1.8802497975	0.0527515448382863	0.000014	-1	18.9567908023466	0.000014	1	GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0016021,integral component of membrane;GO:0005886,plasma membrane		GO:1902807,negative regulation of cell cycle G1/S phase transition;GO:0051782,negative regulation of cell division	
CYTB_HUMAN	P04080	CSTB	Cystatin-B	6.805487522	48.86874742	7.397729589	6.226791155	27.837117471	6.812260372	27.837117471	6.812260372	4.08632611657316	0.087820	0	0.244718598435949	0.087319	0	GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0005730,nucleolus;GO:0005634,nucleus;GO:0034774,secretory granule lumen;GO:1904724,tertiary granule lumen	GO:0004869,cysteine-type endopeptidase inhibitor activity;GO:0004866,endopeptidase inhibitor activity;GO:0002020,protease binding;GO:0003723,RNA binding	GO:0008344,adult locomotory behavior;GO:0010466,negative regulation of peptidase activity;GO:0045861,negative regulation of proteolysis;GO:0043312,neutrophil degranulation	
SNX27_HUMAN	Q96L92	SNX27	Sorting nexin-27	0.547126524	0.554552958	1.089659627	1.102447848	0.550839741	1.0960537375	0.550839741	1.0960537375	0.502566363448945	0.227494	0	1.98978696691385	0.227822	0	GO:0005829,cytosol;GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0005768,endosome;GO:0001772,immunological synapse;GO:0005654,nucleoplasm;GO:0016020,membrane;GO:0005856,cytoskeleton	GO:0035091,phosphatidylinositol binding;GO:0032266,phosphatidylinositol-3-phosphate binding	GO:0032456,endocytic recycling;GO:0016197,endosomal transport;GO:0008333,endosome to lysosome transport;GO:0001770,establishment of natural killer cell polarity;GO:0006886,intracellular protein transport;GO:0007165,signal transduction	
ERO1A_HUMAN	Q96HE7	ERO1A	ERO1-like protein alpha	6.942895423	3.412592454	6.44010686	2.586755781	5.1777439385	4.5134313205	5.1777439385	4.5134313205	1.14718571544064	0.388365	0	0.871698441272773	0.388074	0	GO:0030425,dendrite;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane	GO:0016491,oxidoreductase activity;GO:0016671,oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;GO:0003756,protein disulfide isomerase activity;GO:0015035,protein disulfide oxidoreductase activity	GO:0010260,animal organ senescence;GO:0050873,brown fat cell differentiation;GO:0045454,cell redox homeostasis;GO:0006464,cellular protein modification process;GO:0071456,cellular response to hypoxia;GO:0034599,cellular response to oxidative stress;GO:0051085,chaperone cofactor-dependent protein refolding;GO:0030968,endoplasmic reticulum unfolded protein response;GO:0030198,extracellular matrix organization;GO:0070059,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0018401,peptidyl-proline hydroxylation to 4-hydroxy-L-proline;GO:0006457,protein folding;GO:0034975,protein folding in endoplasmic reticulum;GO:0022417,protein maturation by protein folding;GO:0051209,release of sequestered calcium ion into cytosol;GO:0034976,response to endoplasmic reticulum stress;GO:0009266,response to temperature stimulus	hsa:30001,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:30001,path:hsa05110,Vibrio cholerae infection
NUDT5_HUMAN	Q9UKK9	NUDT5	ADP-sugar pyrophosphatase	0.544774026	0.284319067	0.51077663	0.350734208	0.4145465465	0.430755419	0.4145465465	0.430755419	0.96237105376961	0.446100	0	1.03910024733495	0.445931	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0044715,8-oxo-dGDP phosphatase activity;GO:0044716,8-oxo-GDP phosphatase activity;GO:0047631,ADP-ribose diphosphatase activity;GO:0019144,ADP-sugar diphosphatase activity;GO:0042802,identical protein binding;GO:0000287,magnesium ion binding;GO:0016779,nucleotidyltransferase activity;GO:0042803,protein homodimerization activity;GO:0030515,snoRNA binding;GO:0016787,hydrolase activity;GO:0017110,nucleoside-diphosphatase activity	GO:1990966,ATP generation from poly-ADP-D-ribose;GO:0006338,chromatin remodeling;GO:0019303,D-ribose catabolic process;GO:0034656,nucleobase-containing small molecule catabolic process;GO:0006753,nucleoside phosphate metabolic process;GO:0009117,nucleotide metabolic process;GO:0009191,ribonucleoside diphosphate catabolic process;GO:0019693,ribose phosphate metabolic process;GO:0006139,nucleobase-containing compound metabolic process	hsa:11164,path:hsa00230,Purine metabolism
PTSS1_HUMAN	P48651	PTDSS1	Phosphatidylserine synthase 1	0.140047582	0.109663446	0.40504096	0.243852992	0.124855514	0.324446976	0.124855514	0.324446976	0.384825636346816	0.124032	0	2.598579474832	0.124351	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0106258,L-serine-phosphatidylcholine phosphatidyltransferase activity;GO:0106245,L-serine-phosphatidylethanolamine phosphatidyltransferase activity	GO:0006659,phosphatidylserine biosynthetic process	hsa:9791,path:hsa00564,Glycerophospholipid metabolism
SRC_HUMAN	P12931	SRC	Proto-oncogene tyrosine-protein kinase Src	0.61142752	0.625318524	0.660991212	0.927282947	0.618373022	0.7941370795	0.618373022	0.7941370795	0.778672899128871	0.468924	0	1.28423629629172	0.469050	0	GO:0005884,actin filament;GO:0005901,caveola;GO:0030054,cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0005770,late endosome;GO:0005764,lysosome;GO:0045121,membrane raft;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0043005,neuron projection;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0002102,podosome;GO:0014069,postsynaptic density;GO:0099091,postsynaptic specialization, intracellular component;GO:0032587,ruffle membrane	GO:0005524,ATP binding;GO:0051117,ATPase binding;GO:0070700,BMP receptor binding;GO:0045296,cadherin binding;GO:0071253,connexin binding;GO:0019899,enzyme binding;GO:0046875,ephrin receptor binding;GO:0030331,estrogen receptor binding;GO:0070851,growth factor receptor binding;GO:0020037,heme binding;GO:0005158,insulin receptor binding;GO:0005178,integrin binding;GO:0044325,ion channel binding;GO:0019900,kinase binding;GO:0004715,non-membrane spanning protein tyrosine kinase activity;GO:0016004,phospholipase activator activity;GO:0043274,phospholipase binding;GO:0051219,phosphoprotein binding;GO:0008022,protein C-terminus binding;GO:0004672,protein kinase activity;GO:0005080,protein kinase C binding;GO:0004713,protein tyrosine kinase activity;GO:0097110,scaffold protein binding;GO:0042169,SH2 domain binding;GO:0005102,signaling receptor binding;GO:0004714,transmembrane receptor protein tyrosine kinase activity;GO:0031625,ubiquitin protein ligase binding	GO:0032148,activation of protein kinase B activity;GO:0034332,adherens junction organization;GO:0086098,angiotensin-activated signaling pathway involved in heart process;GO:0007411,axon guidance;GO:0045453,bone resorption;GO:0060444,branching involved in mammary gland duct morphogenesis;GO:0007155,cell adhesion;GO:0007049,cell cycle;GO:0030154,cell differentiation;GO:0008283,cell population proliferation;GO:0098609,cell-cell adhesion;GO:0071398,cellular response to fatty acid;GO:0071498,cellular response to fluid shear stress;GO:0070301,cellular response to hydrogen peroxide;GO:0071456,cellular response to hypoxia;GO:0032869,cellular response to insulin stimulus;GO:0071222,cellular response to lipopolysaccharide;GO:0071375,cellular response to peptide hormone stimulus;GO:0036120,cellular response to platelet-derived growth factor stimulus;GO:0071393,cellular response to progesterone stimulus;GO:0035635,entry of bacterium into host cell;GO:0048013,ephrin receptor signaling pathway;GO:0007173,epidermal growth factor receptor signaling pathway;GO:0038128,ERBB2 signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0048041,focal adhesion assembly;GO:0030900,forebrain development;GO:0007186,G protein-coupled receptor signaling pathway;GO:0045087,innate immune response;GO:0007229,integrin-mediated signaling pathway;GO:0070102,interleukin-6-mediated signaling pathway;GO:0060576,intestinal epithelial cell development;GO:0035556,intracellular signal transduction;GO:0050900,leukocyte migration;GO:0016236,macroautophagy;GO:2000811,negative regulation of anoikis;GO:0043066,negative regulation of apoptotic process;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:2001237,negative regulation of extrinsic apoptotic signaling pathway;GO:0051895,negative regulation of focal adhesion assembly;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:2001243,negative regulation of intrinsic apoptotic signaling pathway;GO:0051902,negative regulation of mitochondrial depolarization;GO:0031333,negative regulation of protein-containing complex assembly;GO:0051974,negative regulation of telomerase activity;GO:0032211,negative regulation of telomere maintenance via telomerase;GO:0045892,negative regulation of transcription, DNA-templated;GO:0048011,neurotrophin TRK receptor signaling pathway;GO:0042476,odontogenesis;GO:0048477,oogenesis;GO:0036035,osteoclast development;GO:0018105,peptidyl-serine phosphorylation;GO:0038083,peptidyl-tyrosine autophosphorylation;GO:0018108,peptidyl-tyrosine phosphorylation;GO:0030168,platelet activation;GO:0043065,positive regulation of apoptotic process;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0045737,positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0001819,positive regulation of cytokine production;GO:0035306,positive regulation of dephosphorylation;GO:2000573,positive regulation of DNA biosynthetic process;GO:0010634,positive regulation of epithelial cell migration;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0010907,positive regulation of glucose metabolic process;GO:0046628,positive regulation of insulin receptor signaling pathway;GO:0033625,positive regulation of integrin activation;GO:2000394,positive regulation of lamellipodium morphogenesis;GO:0043406,positive regulation of MAP kinase activity;GO:1903997,positive regulation of non-membrane spanning protein tyrosine kinase activity;GO:0045747,positive regulation of Notch signaling pathway;GO:2000386,positive regulation of ovarian follicle development;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0043552,positive regulation of phosphatidylinositol 3-kinase activity;GO:0014068,positive regulation of phosphatidylinositol 3-kinase signaling;GO:2000588,positive regulation of platelet-derived growth factor receptor-beta signaling pathway;GO:0071803,positive regulation of podosome assembly;GO:0031954,positive regulation of protein autophosphorylation;GO:0051897,positive regulation of protein kinase B signaling;GO:1900182,positive regulation of protein localization to nucleus;GO:0010954,positive regulation of protein processing;GO:0071902,positive regulation of protein serine/threonine kinase activity;GO:0051222,positive regulation of protein transport;GO:0051057,positive regulation of small GTPase mediated signal transduction;GO:0014911,positive regulation of smooth muscle cell migration;GO:0045893,positive regulation of transcription, DNA-templated;GO:0001545,primary ovarian follicle growth;GO:0050847,progesterone receptor signaling pathway;GO:0046777,protein autophosphorylation;GO:0031648,protein destabilization;GO:0045124,regulation of bone resorption;GO:2001286,regulation of caveolin-mediated endocytosis;GO:0060491,regulation of cell projection assembly;GO:0022407,regulation of cell-cell adhesion;GO:2000641,regulation of early endosome to late endosome transport;GO:0010632,regulation of epithelial cell migration;GO:0033146,regulation of intracellular estrogen receptor signaling pathway;GO:0098962,regulation of postsynaptic neurotransmitter receptor activity;GO:0043393,regulation of protein binding;GO:0043114,regulation of vascular permeability;GO:0010447,response to acidic pH;GO:0042493,response to drug;GO:0051602,response to electrical stimulus;GO:0070555,response to interleukin-1;GO:0009612,response to mechanical stimulus;GO:0051385,response to mineralocorticoid;GO:0031667,response to nutrient levels;GO:0009615,response to virus;GO:0007172,signal complex assembly;GO:0007165,signal transduction;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0043149,stress fiber assembly;GO:0034446,substrate adhesion-dependent cell spreading;GO:0031295,T cell costimulation;GO:0045056,transcytosis;GO:0007179,transforming growth factor beta receptor signaling pathway;GO:0007169,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0060065,uterus development;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:0016032,viral process	hsa:6714,path:hsa04015,Rap1 signaling pathway;hsa:6714,path:hsa04012,ErbB signaling pathway;hsa:6714,path:hsa04370,VEGF signaling pathway;hsa:6714,path:hsa04144,Endocytosis;hsa:6714,path:hsa04137,Mitophagy - animal;hsa:6714,path:hsa04510,Focal adhesion;hsa:6714,path:hsa04520,Adherens junction;hsa:6714,path:hsa04530,Tight junction;hsa:6714,path:hsa04540,Gap junction;hsa:6714,path:hsa04810,Regulation of actin cytoskeleton;hsa:6714,path:hsa04611,Platelet activation;hsa:6714,path:hsa04625,C-type lectin receptor signaling pathway;hsa:6714,path:hsa04062,Chemokine signaling pathway;hsa:6714,path:hsa04912,GnRH signaling pathway;hsa:6714,path:hsa04915,Estrogen signaling pathway;hsa:6714,path:hsa04917,Prolactin signaling pathway;hsa:6714,path:hsa04921,Oxytocin signaling pathway;hsa:6714,path:hsa04926,Relaxin signaling pathway;hsa:6714,path:hsa04919,Thyroid hormone signaling pathway;hsa:6714,path:hsa04727,GABAergic synapse;hsa:6714,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:6714,path:hsa04360,Axon guidance;hsa:6714,path:hsa05205,Proteoglycans in cancer;hsa:6714,path:hsa05203,Viral carcinogenesis;hsa:6714,path:hsa05219,Bladder cancer;hsa:6714,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:6714,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:6714,path:hsa05131,Shigellosis;hsa:6714,path:hsa05135,Yersinia infection;hsa:6714,path:hsa05152,Tuberculosis;hsa:6714,path:hsa05100,Bacterial invasion of epithelial cells;hsa:6714,path:hsa05161,Hepatitis B;hsa:6714,path:hsa05168,Herpes simplex virus 1 infection;hsa:6714,path:hsa05163,Human cytomegalovirus infection;hsa:6714,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:6714,path:hsa01521,EGFR tyrosine kinase inhibitor resistance;hsa:6714,path:hsa01522,Endocrine resistance
ETFB_HUMAN	P38117	ETFB	Electron transfer flavoprotein subunit beta	2.817170235	13.45681902	4.642100869	1.555887026	8.1369946275	3.0989939475	8.1369946275	3.0989939475	2.62568909954284	0.163173	0	0.380852401822481	0.162602	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0009055,electron transfer activity	GO:0033539,fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0022904,respiratory electron transport chain	
MFGM_HUMAN	Q08431	MFGE8	Lactadherin	0.100608798	0.055134891	0.092543278	0.421485224	0.0778718445	0.257014251	0.0778718445	0.257014251	0.302986484978998	0.064197	0	3.3004772475885	0.064446	0	GO:0002080,acrosomal membrane;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1903561,extracellular vesicle;GO:0019897,extrinsic component of plasma membrane;GO:0016020,membrane	GO:0005178,integrin binding;GO:0008429,phosphatidylethanolamine binding;GO:0001786,phosphatidylserine binding	GO:1990000,amyloid fibril formation;GO:0001525,angiogenesis;GO:0043277,apoptotic cell clearance;GO:0007155,cell adhesion;GO:0044267,cellular protein metabolic process;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050766,positive regulation of phagocytosis;GO:0043687,post-translational protein modification;GO:0007338,single fertilization	
LEG3_HUMAN	P17931	LGALS3	Galectin-3	11.35215175	39.17941507	11.33791983	16.47764103	25.26578341	13.90778043	25.26578341	13.90778043	1.81666539367418	0.251097	0	0.550459101319431	0.250580	0	GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0101003,ficolin-1-rich granule membrane;GO:0001772,immunological synapse;GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005634,nucleus;GO:0044216,other organism cell;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0005681,spliceosomal complex	GO:0030246,carbohydrate binding;GO:0042056,chemoattractant activity;GO:0019863,IgE binding;GO:0043236,laminin binding;GO:0070492,oligosaccharide binding;GO:0019903,protein phosphatase binding;GO:0004864,protein phosphatase inhibitor activity;GO:0003723,RNA binding	GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0048245,eosinophil chemotaxis;GO:0030855,epithelial cell differentiation;GO:0045087,innate immune response;GO:0031640,killing of cells of other organism;GO:0048246,macrophage chemotaxis;GO:0002548,monocyte chemotaxis;GO:0071674,mononuclear cell migration;GO:0006397,mRNA processing;GO:0045806,negative regulation of endocytosis;GO:2001237,negative regulation of extrinsic apoptotic signaling pathway;GO:2000521,negative regulation of immunological synapse formation;GO:1903614,negative regulation of protein tyrosine phosphatase activity;GO:2001189,negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0050860,negative regulation of T cell receptor signaling pathway;GO:0030593,neutrophil chemotaxis;GO:0043312,neutrophil degranulation;GO:0050918,positive chemotaxis;GO:0090280,positive regulation of calcium ion import;GO:0071677,positive regulation of mononuclear cell migration;GO:1903078,positive regulation of protein localization to plasma membrane;GO:0031334,positive regulation of protein-containing complex assembly;GO:1902041,regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0045637,regulation of myeloid cell differentiation;GO:0070232,regulation of T cell apoptotic process;GO:0042129,regulation of T cell proliferation;GO:0008380,RNA splicing	
RT30_HUMAN	Q9NP92	MRPS30	39S ribosomal protein S30, mitochondrial	0.104152277	0.068333251	0.14928786	2.55E-05	0.086242764	0.07465668	0.086242764	0.07465668	1.15519152472357	0.386120	0	0.86565732053764	0.385825	0	GO:0005743,mitochondrial inner membrane;GO:0005762,mitochondrial large ribosomal subunit;GO:0005739,mitochondrion	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0006915,apoptotic process;GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination	
GOLP3_HUMAN	Q9H4A6	GOLPH3	Golgi phosphoprotein 3	0.081875008	0.075264637	0.3736432	0.314211598	0.0785698225	0.343927399	0.0785698225	0.343927399	0.228448860801579	0.025470	-1	4.3773472824124	0.025616	1	GO:0005829,cytosol;GO:0005768,endosome;GO:0005794,Golgi apparatus;GO:0031985,Golgi cisterna;GO:0032580,Golgi cisterna membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005758,mitochondrial intermembrane space;GO:0005739,mitochondrion;GO:0005886,plasma membrane;GO:0005802,trans-Golgi network	GO:0019899,enzyme binding;GO:0070273,phosphatidylinositol-4-phosphate binding	GO:0090164,asymmetric Golgi ribbon formation;GO:0060352,cell adhesion molecule production;GO:0016477,cell migration;GO:0072752,cellular response to rapamycin;GO:0010467,gene expression;GO:0009101,glycoprotein biosynthetic process;GO:0007030,Golgi organization;GO:0090161,Golgi ribbon formation;GO:0043001,Golgi to plasma membrane protein transport;GO:0048194,Golgi vesicle budding;GO:0030032,lamellipodium assembly;GO:0050901,leukocyte tethering or rolling;GO:0043066,negative regulation of apoptotic process;GO:0050714,positive regulation of protein secretion;GO:0032008,positive regulation of TOR signaling;GO:0045053,protein retention in Golgi apparatus;GO:0009306,protein secretion;GO:0010821,regulation of mitochondrion organization;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	
BAK_HUMAN	Q16611	BAK1	Bcl-2 homologous antagonist/killer	0.283990336	3.313942831	0.123646563	0.25897542	1.7989665835	0.1913109915	1.7989665835	0.1913109915	9.40336239645698	0.019855	1	0.106344938952558	0.019629	-1	GO:0097145,BAK complex;GO:0097136,Bcl-2 family protein complex;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0031307,integral component of mitochondrial outer membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0046930,pore complex;GO:0016021,integral component of membrane	GO:0051400,BH domain binding;GO:0051087,chaperone binding;GO:0031072,heat shock protein binding;GO:0042802,identical protein binding;GO:0044325,ion channel binding;GO:0046872,metal ion binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0044877,protein-containing complex binding	GO:0097202,activation of cysteine-type endopeptidase activity;GO:0008635,activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;GO:0007568,aging;GO:0031100,animal organ regeneration;GO:0006915,apoptotic process;GO:1902262,apoptotic process involved in blood vessel morphogenesis;GO:0097190,apoptotic signaling pathway;GO:0001783,B cell apoptotic process;GO:0001782,B cell homeostasis;GO:0002352,B cell negative selection;GO:0001974,blood vessel remodeling;GO:0007420,brain development;GO:0008283,cell population proliferation;GO:0071260,cellular response to mechanical stimulus;GO:0034620,cellular response to unfolded protein;GO:0034644,cellular response to UV;GO:0031018,endocrine pancreas development;GO:0032469,endoplasmic reticulum calcium ion homeostasis;GO:0010248,establishment or maintenance of transmembrane electrochemical gradient;GO:0097192,extrinsic apoptotic signaling pathway in absence of ligand;GO:0044346,fibroblast apoptotic process;GO:0008630,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0070059,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0035108,limb morphogenesis;GO:0008053,mitochondrial fusion;GO:0002262,myeloid cell homeostasis;GO:0008285,negative regulation of cell population proliferation;GO:0032471,negative regulation of endoplasmic reticulum calcium ion concentration;GO:0010629,negative regulation of gene expression;GO:0033137,negative regulation of peptidyl-serine phosphorylation;GO:0043065,positive regulation of apoptotic process;GO:0010524,positive regulation of calcium ion transport into cytosol;GO:1900103,positive regulation of endoplasmic reticulum unfolded protein response;GO:1903896,positive regulation of IRE1-mediated unfolded protein response;GO:1901030,positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:0031334,positive regulation of protein-containing complex assembly;GO:0045862,positive regulation of proteolysis;GO:0090200,positive regulation of release of cytochrome c from mitochondria;GO:0048597,post-embryonic camera-type eye morphogenesis;GO:0051726,regulation of cell cycle;GO:0046902,regulation of mitochondrial membrane permeability;GO:0051881,regulation of mitochondrial membrane potential;GO:0001836,release of cytochrome c from mitochondria;GO:0042493,response to drug;GO:0045471,response to ethanol;GO:0009620,response to fungus;GO:0010332,response to gamma radiation;GO:0042542,response to hydrogen peroxide;GO:0010046,response to mycotoxin;GO:0014070,response to organic cyclic compound;GO:0010225,response to UV-C;GO:0070242,thymocyte apoptotic process;GO:0060068,vagina development;GO:0016032,viral process	hsa:578,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:578,path:hsa04210,Apoptosis;hsa:578,path:hsa04215,Apoptosis - multiple species;hsa:578,path:hsa05200,Pathways in cancer;hsa:578,path:hsa05202,Transcriptional misregulation in cancer;hsa:578,path:hsa05206,MicroRNAs in cancer;hsa:578,path:hsa05203,Viral carcinogenesis;hsa:578,path:hsa05210,Colorectal cancer;hsa:578,path:hsa05212,Pancreatic cancer;hsa:578,path:hsa05225,Hepatocellular carcinoma;hsa:578,path:hsa05226,Gastric cancer;hsa:578,path:hsa05214,Glioma;hsa:578,path:hsa05216,Thyroid cancer;hsa:578,path:hsa05220,Chronic myeloid leukemia;hsa:578,path:hsa05217,Basal cell carcinoma;hsa:578,path:hsa05218,Melanoma;hsa:578,path:hsa05213,Endometrial cancer;hsa:578,path:hsa05224,Breast cancer;hsa:578,path:hsa05222,Small cell lung cancer;hsa:578,path:hsa05223,Non-small cell lung cancer;hsa:578,path:hsa05130,Pathogenic Escherichia coli infection;hsa:578,path:hsa05132,Salmonella infection;hsa:578,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:578,path:hsa05162,Measles;hsa:578,path:hsa05164,Influenza A;hsa:578,path:hsa05160,Hepatitis C;hsa:578,path:hsa05168,Herpes simplex virus 1 infection;hsa:578,path:hsa05163,Human cytomegalovirus infection;hsa:578,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:578,path:hsa05169,Epstein-Barr virus infection;hsa:578,path:hsa05165,Human papillomavirus infection;hsa:578,path:hsa01524,Platinum drug resistance
KCD12_HUMAN	Q96CX2	KCTD12	BTB/POZ domain-containing protein KCTD12	3.43556704	7.163418368	6.547222341	10.85809629	5.299492704	8.7026593155	5.299492704	8.7026593155	0.608950955320204	0.325025	0	1.64216837376365	0.325295	0	GO:0042995,cell projection;GO:0045211,postsynaptic membrane;GO:0042734,presynaptic membrane	GO:0042802,identical protein binding;GO:0003723,RNA binding	GO:0051260,protein homooligomerization	
NED4L_HUMAN	Q96PU5	NEDD4L	E3 ubiquitin-protein ligase NEDD4-like	0.287904219	0.213559328	0.24096651	0.077617605	0.2507317735	0.1592920575	0.2507317735	0.1592920575	1.57403813746332	0.291088	0	0.635308621944558	0.290624	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0005771,multivesicular body;GO:0005654,nucleoplasm	GO:0044325,ion channel binding;GO:0019870,potassium channel inhibitor activity;GO:0015459,potassium channel regulator activity;GO:0019871,sodium channel inhibitor activity;GO:0017080,sodium channel regulator activity;GO:0061630,ubiquitin protein ligase activity;GO:0004842,ubiquitin-protein transferase activity	GO:0030154,cell differentiation;GO:0006883,cellular sodium ion homeostasis;GO:0007588,excretion;GO:0034220,ion transmembrane transport;GO:1901380,negative regulation of potassium ion transmembrane transport;GO:1901017,negative regulation of potassium ion transmembrane transporter activity;GO:2000009,negative regulation of protein localization to cell surface;GO:1902306,negative regulation of sodium ion transmembrane transport;GO:2000650,negative regulation of sodium ion transmembrane transporter activity;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:2001288,positive regulation of caveolin-mediated endocytosis;GO:1903861,positive regulation of dendrite extension;GO:0045807,positive regulation of endocytosis;GO:0045732,positive regulation of protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936,protein K48-linked ubiquitination;GO:0000209,protein polyubiquitination;GO:0016567,protein ubiquitination;GO:0048814,regulation of dendrite morphogenesis;GO:0034765,regulation of ion transmembrane transport;GO:0003254,regulation of membrane depolarization;GO:0042391,regulation of membrane potential;GO:0060306,regulation of membrane repolarization;GO:1901016,regulation of potassium ion transmembrane transporter activity;GO:0042176,regulation of protein catabolic process;GO:0031647,regulation of protein stability;GO:0010038,response to metal ion;GO:0006814,sodium ion transport;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0086005,ventricular cardiac muscle cell action potential;GO:0019058,viral life cycle;GO:0030104,water homeostasis;GO:0006513,protein monoubiquitination	hsa:23327,path:hsa04120,Ubiquitin mediated proteolysis;hsa:23327,path:hsa04144,Endocytosis;hsa:23327,path:hsa04530,Tight junction;hsa:23327,path:hsa04960,Aldosterone-regulated sodium reabsorption
MCAT_HUMAN	O43772	SLC25A20	Mitochondrial carnitine/acylcarnitine carrier protein	1.016782197	1.953911122	1.513323657	1.552840457	1.4853466595	1.533082057	1.4853466595	1.533082057	0.96886311643787	0.443861	0	1.03213754660886	0.443687	0	GO:0005829,cytosol;GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion	GO:0015227,acyl carnitine transmembrane transporter activity	GO:0006853,carnitine shuttle;GO:1902603,carnitine transmembrane transport;GO:0001701,in utero embryonic development	hsa:788,path:hsa04714,Thermogenesis
SYAC_HUMAN	P49588	AARS1	Alanine--tRNA ligase, cytoplasmic	6.938281361	3.478480077	7.890047212	5.243376881	5.208380719	6.5667120465	5.208380719	6.5667120465	0.793148943050734	0.480131	0	1.26079724213417	0.480244	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005739,mitochondrion	GO:0004813,alanine-tRNA ligase activity;GO:0016597,amino acid binding;GO:0002161,aminoacyl-tRNA editing activity;GO:0005524,ATP binding;GO:0002196,Ser-tRNA(Ala) hydrolase activity;GO:0000049,tRNA binding;GO:0008270,zinc ion binding;GO:0003676,nucleic acid binding;GO:0045182,translation regulator activity	GO:0006419,alanyl-tRNA aminoacylation;GO:0006418,tRNA aminoacylation for protein translation;GO:0006400,tRNA modification;GO:0008033,tRNA processing;GO:0021680,cerebellar Purkinje cell layer development;GO:0043524,negative regulation of neuron apoptotic process;GO:0050885,neuromuscular process controlling balance;GO:0140018,regulation of cytoplasmic translational fidelity	hsa:16,path:hsa00970,Aminoacyl-tRNA biosynthesis
CSK21_HUMAN	P68400	CSNK2A1	Casein kinase II subunit alpha	0.994900451	0.746870937	1.236630837	0.717852929	0.870885694	0.977241883	0.870885694	0.977241883	0.891166976313478	0.471806	0	1.12212416592986	0.471693	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016581,NuRD complex;GO:0005886,plasma membrane;GO:0005956,protein kinase CK2 complex;GO:0016580,Sin3 complex	GO:0005524,ATP binding;GO:0051879,Hsp90 protein binding;GO:0042802,identical protein binding;GO:0016301,kinase activity;GO:0047485,protein N-terminus binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0004672,protein kinase activity	GO:0006915,apoptotic process;GO:0061077,chaperone-mediated protein folding;GO:0016236,macroautophagy;GO:0007076,mitotic chromosome condensation;GO:2001234,negative regulation of apoptotic signaling pathway;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:2000059,negative regulation of ubiquitin-dependent protein catabolic process;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:0006656,phosphatidylcholine biosynthetic process;GO:0030307,positive regulation of cell growth;GO:0008284,positive regulation of cell population proliferation;GO:0045732,positive regulation of protein catabolic process;GO:0030177,positive regulation of Wnt signaling pathway;GO:0006457,protein folding;GO:0006468,protein phosphorylation;GO:0051726,regulation of cell cycle;GO:1905818,regulation of chromosome separation;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0048511,rhythmic process;GO:0007165,signal transduction;GO:0016055,Wnt signaling pathway	hsa:1457,path:hsa03008,Ribosome biogenesis in eukaryotes;hsa:1457,path:hsa04310,Wnt signaling pathway;hsa:1457,path:hsa04064,NF-kappa B signaling pathway;hsa:1457,path:hsa04137,Mitophagy - animal;hsa:1457,path:hsa04520,Adherens junction;hsa:1457,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:1457,path:hsa05162,Measles
RS5_HUMAN	P46782	RPS5	40S ribosomal protein S5	8.323459214	14.27952859	1.741237861	0.394027363	11.301493902	1.067632612	11.301493902	1.067632612	10.5855645237634	0.015519	1	0.0944682730670733	0.015328	-1	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:1990904,ribonucleoprotein complex;GO:0005840,ribosome;GO:0015935,small ribosomal subunit	GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0019843,rRNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006450,regulation of translational fidelity;GO:0000028,ribosomal small subunit assembly;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6193,path:hsa03010,Ribosome
RS9_HUMAN	P46781	RPS9	40S ribosomal protein S9	9.250777368	45.79999601	2.681655075	1.008493567	27.525386689	1.845074321	27.525386689	1.845074321	14.9183078295088	0.007227	1	0.0670317311740928	0.007116	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0005840,ribosome;GO:0015935,small ribosomal subunit;GO:0045202,synapse	GO:0003723,RNA binding;GO:0019843,rRNA binding;GO:0003735,structural constituent of ribosome;GO:0045182,translation regulator activity	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0008284,positive regulation of cell population proliferation;GO:0045903,positive regulation of translational fidelity;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6203,path:hsa03010,Ribosome
SRSF1_HUMAN	Q07955	SRSF1	Serine/arginine-rich splicing factor 1	6.531937936	7.494540687	5.183130995	4.085682398	7.0132393115	4.6344066965	7.0132393115	4.6344066965	1.5132981999177	0.302564	0	0.660808292809958	0.302118	0	GO:0071013,catalytic step 2 spliceosome;GO:0005737,cytoplasm;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0044547,DNA topoisomerase binding;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0043422,protein kinase B binding	GO:0000380,alternative mRNA splicing, via spliceosome;GO:0031124,mRNA 3'-end processing;GO:0000395,mRNA 5'-splice site recognition;GO:0006406,mRNA export from nucleus;GO:0006397,mRNA processing;GO:0006376,mRNA splice site selection;GO:0000398,mRNA splicing, via spliceosome;GO:0006405,RNA export from nucleus;GO:0097421,liver regeneration;GO:0048709,oligodendrocyte differentiation;GO:0033120,positive regulation of RNA splicing	hsa:6426,path:hsa03040,Spliceosome;hsa:6426,path:hsa04657,IL-17 signaling pathway;hsa:6426,path:hsa05168,Herpes simplex virus 1 infection
EI2BE_HUMAN	Q13144	EIF2B5	Translation initiation factor eIF-2B subunit epsilon	0.014426029	0.018945837	0.067774788	0.019558661	0.016685933	0.0436667245	0.016685933	0.0436667245	0.382120096963078	0.121839	0	2.61697829543005	0.122156	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005851,eukaryotic translation initiation factor 2B complex;GO:0005634,nucleus	GO:0005085,guanyl-nucleotide exchange factor activity;GO:0003743,translation initiation factor activity;GO:0031369,translation initiation factor binding	GO:0014002,astrocyte development;GO:0048708,astrocyte differentiation;GO:0042552,myelination;GO:0014003,oligodendrocyte development;GO:0001541,ovarian follicle development;GO:0045948,positive regulation of translational initiation;GO:0034976,response to endoplasmic reticulum stress;GO:0009749,response to glucose;GO:0009408,response to heat;GO:0043434,response to peptide hormone;GO:0050852,T cell receptor signaling pathway;GO:0006413,translational initiation;GO:0007568,aging;GO:0021766,hippocampus development;GO:0043065,positive regulation of apoptotic process;GO:0045727,positive regulation of translation;GO:0010226,response to lithium ion	hsa:8893,path:hsa03013,RNA transport;hsa:8893,path:hsa05168,Herpes simplex virus 1 infection
IR3IP_HUMAN	Q9Y5U9	IER3IP1	Immediate early response 3-interacting protein 1	0.583832515	0.61708774	0.407875426	2.55E-05	0.6004601275	0.203950463	0.6004601275	0.203950463	2.94414692012736	0.140519	0	0.33965696248499	0.139955	0	GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0030173,integral component of Golgi membrane;GO:0016020,membrane;GO:0016021,integral component of membrane		GO:0007420,brain development;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0035265,organ growth;GO:0003331,positive regulation of extracellular matrix constituent secretion;GO:0050714,positive regulation of protein secretion;GO:0015031,protein transport;GO:2000269,regulation of fibroblast apoptotic process	
PML_HUMAN	P29590	PML	Protein PML	7.456373109	8.13575494	7.808186526	10.15198319	7.7960640245	8.980084858	7.7960640245	8.980084858	0.868150373607527	0.480589	0	1.15187418032729	0.480495	0	GO:0000785,chromatin;GO:0000781,chromosome, telomeric region;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0042406,extrinsic component of endoplasmic reticulum membrane;GO:0000792,heterochromatin;GO:0016363,nuclear matrix;GO:0031965,nuclear membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016605,PML body	GO:0050897,cobalt ion binding;GO:0003677,DNA binding;GO:0042802,identical protein binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0046332,SMAD binding;GO:0032183,SUMO binding;GO:0140037,sumo-dependent protein binding;GO:0003713,transcription coactivator activity;GO:0031625,ubiquitin protein ligase binding;GO:0004842,ubiquitin-protein transferase activity;GO:0008270,zinc ion binding	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006915,apoptotic process;GO:0060444,branching involved in mammary gland duct morphogenesis;GO:0007050,cell cycle arrest;GO:0045165,cell fate commitment;GO:0071353,cellular response to interleukin-4;GO:1990830,cellular response to leukemia inhibitory factor;GO:0090398,cellular senescence;GO:0032922,circadian regulation of gene expression;GO:0007182,common-partner SMAD protein phosphorylation;GO:0051607,defense response to virus;GO:0006977,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0032469,endoplasmic reticulum calcium ion homeostasis;GO:0043153,entrainment of circadian clock by photoperiod;GO:0097191,extrinsic apoptotic signaling pathway;GO:0010761,fibroblast migration;GO:0030851,granulocyte differentiation;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0008630,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0042771,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0070059,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0008631,intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0051457,maintenance of protein location in nucleus;GO:0016525,negative regulation of angiogenesis;GO:0030308,negative regulation of cell growth;GO:0008285,negative regulation of cell population proliferation;GO:0032691,negative regulation of interleukin-1 beta production;GO:0045930,negative regulation of mitotic cell cycle;GO:0051974,negative regulation of telomerase activity;GO:0032211,negative regulation of telomere maintenance via telomerase;GO:0045892,negative regulation of transcription, DNA-templated;GO:0032938,negative regulation of translation in response to oxidative stress;GO:2000059,negative regulation of ubiquitin-dependent protein catabolic process;GO:1902187,negative regulation of viral release from host cell;GO:0030578,PML body organization;GO:0060058,positive regulation of apoptotic process involved in mammary gland involution;GO:0002230,positive regulation of defense response to virus by host;GO:2001238,positive regulation of extrinsic apoptotic signaling pathway;GO:0048146,positive regulation of fibroblast proliferation;GO:0031065,positive regulation of histone deacetylation;GO:1904816,positive regulation of protein localization to chromosome, telomeric region;GO:0032206,positive regulation of telomere maintenance;GO:0045893,positive regulation of transcription, DNA-templated;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006606,protein import into nucleus;GO:0050821,protein stabilization;GO:0006605,protein targeting;GO:0065003,protein-containing complex assembly;GO:0010522,regulation of calcium ion transport into cytosol;GO:0030155,regulation of cell adhesion;GO:0042752,regulation of circadian rhythm;GO:2000779,regulation of double-strand break repair;GO:0001932,regulation of protein phosphorylation;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0006355,regulation of transcription, DNA-templated;GO:0034097,response to cytokine;GO:0010332,response to gamma radiation;GO:0001666,response to hypoxia;GO:0009411,response to UV;GO:0048384,retinoic acid receptor signaling pathway;GO:0007179,transforming growth factor beta receptor signaling pathway;GO:0019058,viral life cycle	hsa:5371,path:hsa04120,Ubiquitin mediated proteolysis;hsa:5371,path:hsa04144,Endocytosis;hsa:5371,path:hsa05200,Pathways in cancer;hsa:5371,path:hsa05202,Transcriptional misregulation in cancer;hsa:5371,path:hsa05221,Acute myeloid leukemia;hsa:5371,path:hsa05164,Influenza A;hsa:5371,path:hsa05168,Herpes simplex virus 1 infection
HKDC1_HUMAN	Q2TB90	HKDC1	Hexokinase HKDC1	2.55E-05	0.036422743	0.006881084	0.164631917	0.0182241215	0.0857565005	0.0182241215	0.0857565005	0.212510088375166	0.019579	-1	4.70565895316271	0.019703	1	GO:0005829,cytosol;GO:0031966,mitochondrial membrane;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0008865,fructokinase activity;GO:0004340,glucokinase activity;GO:0005536,glucose binding;GO:0019158,mannokinase activity	GO:0001678,cellular glucose homeostasis;GO:0051156,glucose 6-phosphate metabolic process;GO:0006096,glycolytic process;GO:0019318,hexose metabolic process	hsa:80201,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:80201,path:hsa00051,Fructose and mannose metabolism;hsa:80201,path:hsa00052,Galactose metabolism;hsa:80201,path:hsa00500,Starch and sucrose metabolism;hsa:80201,path:hsa00520,Amino sugar and nucleotide sugar metabolism;hsa:80201,path:hsa00524,Neomycin, kanamycin and gentamicin biosynthesis;hsa:80201,path:hsa04066,HIF-1 signaling pathway;hsa:80201,path:hsa04910,Insulin signaling pathway;hsa:80201,path:hsa04973,Carbohydrate digestion and absorption;hsa:80201,path:hsa05230,Central carbon metabolism in cancer;hsa:80201,path:hsa04930,Type II diabetes mellitus;hsa:80201,path:hsa05131,Shigellosis
HNRDL_HUMAN	O14979	HNRNPDL	Heterogeneous nuclear ribonucleoprotein D-like	0.426492281	7.60933463	1.287967251	1.800003071	4.0179134555	1.543985161	4.0179134555	1.543985161	2.60230056414383	0.165038	0	0.384275365335828	0.164468	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0005737,cytoplasm	GO:0003677,DNA binding;GO:0003690,double-stranded DNA binding;GO:0008143,poly(A) binding;GO:0034046,poly(G) binding;GO:0003723,RNA binding;GO:0003697,single-stranded DNA binding	GO:0035722,interleukin-12-mediated signaling pathway;GO:0010468,regulation of gene expression;GO:0006396,RNA processing	
TRFM_HUMAN	P08582	MELTF	Melanotransferrin	0.105893548	0.118033565	0.339813926	0.137168712	0.1119635565	0.238491319	0.1119635565	0.238491319	0.469465961987489	0.197317	0	2.13007988005454	0.197652	0	GO:0046658,anchored component of plasma membrane;GO:0009986,cell surface;GO:0005769,early endosome;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane;GO:0055037,recycling endosome	GO:0005506,iron ion binding	GO:0044267,cellular protein metabolic process;GO:0055072,iron ion homeostasis;GO:0006826,iron ion transport;GO:1900025,negative regulation of substrate adhesion-dependent cell spreading;GO:0090091,positive regulation of extracellular matrix disassembly;GO:0010756,positive regulation of plasminogen activation;GO:0043687,post-translational protein modification	
FBLN1_HUMAN	P23142	FBLN1	Fibulin-1	16.21595567	15.48507659	6.388216911	14.06622527	15.85051613	10.2272210905	15.85051613	10.2272210905	1.54983606883432	0.295583	0	0.64522953111559	0.295125	0	GO:0062023,collagen-containing extracellular matrix;GO:0071953,elastic fiber;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005604,basement membrane	GO:0005509,calcium ion binding;GO:0005201,extracellular matrix structural constituent;GO:0070051,fibrinogen binding;GO:0001968,fibronectin binding;GO:0042802,identical protein binding;GO:0005178,integrin binding;GO:0016504,peptidase activator activity;GO:0008022,protein C-terminus binding;GO:0044877,protein-containing complex binding	GO:0072378,blood coagulation, fibrin clot formation;GO:0030198,extracellular matrix organization;GO:0007162,negative regulation of cell adhesion;GO:2000146,negative regulation of cell motility;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:0001933,negative regulation of protein phosphorylation;GO:2000647,negative regulation of stem cell proliferation;GO:1900025,negative regulation of substrate adhesion-dependent cell spreading;GO:1904188,negative regulation of transformation of host cell by virus;GO:0071635,negative regulation of transforming growth factor beta production;GO:0048146,positive regulation of fibroblast proliferation;GO:0010628,positive regulation of gene expression;GO:1904237,positive regulation of substrate-dependent cell migration, cell attachment to substrate;GO:0016032,viral process;GO:0007566,embryo implantation	
ITAV_HUMAN	P06756	ITGAV	Integrin alpha-V	1.275777564	1.547982956	1.031708275	2.543248807	1.41188026	1.787478541	1.41188026	1.787478541	0.789872564965243	0.477611	0	1.26602700784272	0.477727	0	GO:0035868,alphav-beta3 integrin-HMGB1 complex;GO:0035867,alphav-beta3 integrin-IGF-1-IGF1R complex;GO:0035866,alphav-beta3 integrin-PKCalpha complex;GO:0009986,cell surface;GO:0005829,cytosol;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0031527,filopodium membrane;GO:0005925,focal adhesion;GO:0005887,integral component of plasma membrane;GO:0034683,integrin alphav-beta3 complex;GO:0034684,integrin alphav-beta5 complex;GO:0034685,integrin alphav-beta6 complex;GO:0034686,integrin alphav-beta8 complex;GO:0008305,integrin complex;GO:0031258,lamellipodium membrane;GO:0016020,membrane;GO:0031528,microvillus membrane;GO:0045335,phagocytic vesicle;GO:0005886,plasma membrane;GO:0032587,ruffle membrane;GO:0035579,specific granule membrane	GO:0015026,coreceptor activity;GO:0050840,extracellular matrix binding;GO:1990430,extracellular matrix protein binding;GO:0001968,fibronectin binding;GO:0005178,integrin binding;GO:0046872,metal ion binding;GO:0001846,opsonin binding;GO:0002020,protease binding;GO:0005080,protein kinase C binding;GO:0050431,transforming growth factor beta binding;GO:0001618,virus receptor activity;GO:0005245,voltage-gated calcium channel activity	GO:0001525,angiogenesis;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038027,apolipoprotein A-I-mediated signaling pathway;GO:0043277,apoptotic cell clearance;GO:0070588,calcium ion transmembrane transport;GO:0007155,cell adhesion;GO:0033627,cell adhesion mediated by integrin;GO:0007160,cell-matrix adhesion;GO:0031589,cell-substrate adhesion;GO:0035987,endodermal cell differentiation;GO:0085017,entry into host cell by a symbiont-containing vacuole;GO:0070371,ERK1 and ERK2 cascade;GO:0030198,extracellular matrix organization;GO:0097192,extrinsic apoptotic signaling pathway in absence of ligand;GO:0034113,heterotypic cell-cell adhesion;GO:0007229,integrin-mediated signaling pathway;GO:0050900,leukocyte migration;GO:0050919,negative chemotaxis;GO:2000536,negative regulation of entry of bacterium into host cell;GO:2001237,negative regulation of extrinsic apoptotic signaling pathway;GO:0010888,negative regulation of lipid storage;GO:0032369,negative regulation of lipid transport;GO:0050748,negative regulation of lipoprotein metabolic process;GO:1905598,negative regulation of low-density lipoprotein receptor activity;GO:0010745,negative regulation of macrophage derived foam cell differentiation;GO:0043312,neutrophil degranulation;GO:0045785,positive regulation of cell adhesion;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0007204,positive regulation of cytosolic calcium ion concentration;GO:0033690,positive regulation of osteoblast proliferation;GO:0050764,regulation of phagocytosis;GO:1901388,regulation of transforming growth factor beta activation;GO:0034446,substrate adhesion-dependent cell spreading;GO:0071604,transforming growth factor beta production;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:0001570,vasculogenesis;GO:0046718,viral entry into host cell	hsa:3685,path:hsa04151,PI3K-Akt signaling pathway;hsa:3685,path:hsa04512,ECM-receptor interaction;hsa:3685,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3685,path:hsa04145,Phagosome;hsa:3685,path:hsa04510,Focal adhesion;hsa:3685,path:hsa04810,Regulation of actin cytoskeleton;hsa:3685,path:hsa04919,Thyroid hormone signaling pathway;hsa:3685,path:hsa05200,Pathways in cancer;hsa:3685,path:hsa05205,Proteoglycans in cancer;hsa:3685,path:hsa05222,Small cell lung cancer;hsa:3685,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:3685,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:3685,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:3685,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:3685,path:hsa05163,Human cytomegalovirus infection;hsa:3685,path:hsa05165,Human papillomavirus infection
STRAP_HUMAN	Q9Y3F4	STRAP	Serine-threonine kinase receptor-associated protein	1.246356903	0.184462669	1.464460937	0.948744094	0.715409786	1.2066025155	0.715409786	1.2066025155	0.592912559695389	0.310483	0	1.68658933538826	0.310764	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus;GO:0032797,SMN complex;GO:0034719,SMN-Sm protein complex	GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0005102,signaling receptor binding;GO:1990447,U2 snRNP binding	GO:0000380,alternative mRNA splicing, via spliceosome;GO:0030277,maintenance of gastrointestinal epithelium;GO:0010633,negative regulation of epithelial cell migration;GO:0050680,negative regulation of epithelial cell proliferation;GO:0010719,negative regulation of epithelial to mesenchymal transition;GO:0060394,negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0030182,neuron differentiation;GO:0000387,spliceosomal snRNP assembly	hsa:11171,path:hsa03013,RNA transport
RHG01_HUMAN	Q07960	ARHGAP1	Rho GTPase-activating protein 1	8.154519142	5.748441467	9.624670937	7.82341948	6.9514803045	8.7240452085	6.9514803045	8.7240452085	0.796818464182997	0.482942	0	1.25499099851474	0.483052	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0048471,perinuclear region of cytoplasm;GO:0016021,integral component of membrane	GO:0045296,cadherin binding;GO:0005096,GTPase activator activity;GO:0017124,SH3 domain binding;GO:0031267,small GTPase binding	GO:0016197,endosomal transport;GO:2001136,negative regulation of endocytic recycling;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007266,Rho protein signal transduction;GO:0007264,small GTPase mediated signal transduction;GO:0033572,transferrin transport;GO:0007165,signal transduction	
HDAC2_HUMAN	Q92769	HDAC2	Histone deacetylase 2	1.047928951	0.480066132	1.545228931	1.218569338	0.7639975415	1.3818991345	0.7639975415	1.3818991345	0.552860568782707	0.273798	0	1.80877432116711	0.274104	0	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0035098,ESC/E(Z) complex;GO:0000118,histone deacetylase complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016581,NuRD complex;GO:0032991,protein-containing complex;GO:0016580,Sin3 complex;GO:0016021,integral component of membrane	GO:0003682,chromatin binding;GO:0019213,deacetylase activity;GO:0019899,enzyme binding;GO:0031072,heat shock protein binding;GO:0004407,histone deacetylase activity;GO:0042826,histone deacetylase binding;GO:0032041,NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0051059,NF-kappaB binding;GO:1990841,promoter-specific chromatin binding;GO:0033558,protein deacetylase activity;GO:0003723,RNA binding;GO:0001103,RNA polymerase II repressing transcription factor binding;GO:0043565,sequence-specific DNA binding;GO:0008134,transcription factor binding	GO:0043044,ATP-dependent chromatin remodeling;GO:0048149,behavioral response to ethanol;GO:0007596,blood coagulation;GO:0003300,cardiac muscle hypertrophy;GO:1903351,cellular response to dopamine;GO:0034605,cellular response to heat;GO:0070301,cellular response to hydrogen peroxide;GO:0071300,cellular response to retinoic acid;GO:0071560,cellular response to transforming growth factor beta stimulus;GO:0006338,chromatin remodeling;GO:0032922,circadian regulation of gene expression;GO:0016358,dendrite development;GO:0042733,embryonic digit morphogenesis;GO:0009913,epidermal cell differentiation;GO:0061029,eyelid development in camera-type eye;GO:0061198,fungiform papilla formation;GO:0060789,hair follicle placode formation;GO:0070829,heterochromatin maintenance;GO:0016575,histone deacetylation;GO:0070932,histone H3 deacetylation;GO:0070933,histone H4 deacetylation;GO:0043066,negative regulation of apoptotic process;GO:0061000,negative regulation of dendritic spine development;GO:0043392,negative regulation of DNA binding;GO:0043433,negative regulation of DNA-binding transcription factor activity;GO:0045347,negative regulation of MHC class II biosynthetic process;GO:0010977,negative regulation of neuron projection development;GO:2000757,negative regulation of peptidyl-lysine acetylation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0042475,odontogenesis of dentin-containing tooth;GO:0008284,positive regulation of cell population proliferation;GO:0032967,positive regulation of collagen biosynthetic process;GO:0010718,positive regulation of epithelial to mesenchymal transition;GO:0032732,positive regulation of interleukin-1 production;GO:1902437,positive regulation of male mating behavior;GO:0048714,positive regulation of oligodendrocyte differentiation;GO:0045862,positive regulation of proteolysis;GO:2000273,positive regulation of signaling receptor activity;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0032760,positive regulation of tumor necrosis factor production;GO:0042531,positive regulation of tyrosine phosphorylation of STAT protein;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0001975,response to amphetamine;GO:0031000,response to caffeine;GO:0042220,response to cocaine;GO:0042493,response to drug;GO:0055093,response to hyperoxia;GO:0032496,response to lipopolysaccharide;GO:0035094,response to nicotine	hsa:3066,path:hsa04330,Notch signaling pathway;hsa:3066,path:hsa04110,Cell cycle;hsa:3066,path:hsa04919,Thyroid hormone signaling pathway;hsa:3066,path:hsa04213,Longevity regulating pathway - multiple species;hsa:3066,path:hsa05200,Pathways in cancer;hsa:3066,path:hsa05202,Transcriptional misregulation in cancer;hsa:3066,path:hsa05206,MicroRNAs in cancer;hsa:3066,path:hsa05203,Viral carcinogenesis;hsa:3066,path:hsa05220,Chronic myeloid leukemia;hsa:3066,path:hsa05016,Huntington disease;hsa:3066,path:hsa05031,Amphetamine addiction;hsa:3066,path:hsa05034,Alcoholism;hsa:3066,path:hsa05169,Epstein-Barr virus infection;hsa:3066,path:hsa05165,Human papillomavirus infection
CAH3_HUMAN	P07451	CA3	Carbonic anhydrase 3	0.12539264	0.088674776	0.391782854	1.0506638	0.107033708	0.721223327	0.107033708	0.721223327	0.148405776675607	0.004511	-1	6.73828217742396	0.004554	1	GO:0005829,cytosol	GO:0004089,carbonate dehydratase activity;GO:0016836,hydro-lyase activity;GO:0016151,nickel cation binding;GO:0016791,phosphatase activity;GO:0008270,zinc ion binding	GO:0015701,bicarbonate transport;GO:0006730,one-carbon metabolic process;GO:0009617,response to bacterium;GO:0045471,response to ethanol;GO:0006979,response to oxidative stress	hsa:761,path:hsa00910,Nitrogen metabolism
DAAF5_HUMAN	Q86Y56	DNAAF5	Dynein axonemal assembly factor 5	0.131608236	0.587705562	0.169588187	0.090566873	0.359656899	0.13007753	0.359656899	0.13007753	2.76494256156309	0.152668	0	0.361671165940849	0.152099	0	GO:0005737,cytoplasm;GO:0120293,dynein axonemal particle	GO:0045505,dynein intermediate chain binding	GO:0003341,cilium movement;GO:0036159,inner dynein arm assembly;GO:0036158,outer dynein arm assembly	
ARFG2_HUMAN	Q8N6H7	ARFGAP2	ADP-ribosylation factor GTPase-activating protein 2	0.08563576	0.072496501	0.26942839	0.121118404	0.0790661305	0.195273397	0.0790661305	0.195273397	0.404899652050402	0.140661	0	2.46974773857183	0.140988	0	GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005886,plasma membrane	GO:0005096,GTPase activator activity;GO:0046872,metal ion binding	GO:0048205,COPI coating of Golgi vesicle;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0015031,protein transport;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0043547,positive regulation of GTPase activity	hsa:84364,path:hsa04144,Endocytosis
LIN7C_HUMAN	Q9NUP9	LIN7C	Protein lin-7 homolog C	1.07657422	0.892382319	0.176626489	0.033465968	0.9844782695	0.1050462285	0.9844782695	0.1050462285	9.37185735802023	0.019991	1	0.106702434938814	0.019764	-1	GO:0016323,basolateral plasma membrane;GO:0005923,bicellular tight junction;GO:0005911,cell-cell junction;GO:0005737,cytoplasm;GO:0098978,glutamatergic synapse;GO:0097025,MPP7-DLG1-LIN7 complex;GO:0005886,plasma membrane;GO:0098839,postsynaptic density membrane;GO:0098793,presynapse;GO:0045202,synapse;GO:0016328,lateral plasma membrane;GO:0045211,postsynaptic membrane	GO:0008092,cytoskeletal protein binding;GO:0097016,L27 domain binding;GO:0030165,PDZ domain binding;GO:0019904,protein domain specific binding	GO:0006887,exocytosis;GO:0045199,maintenance of epithelial cell apical/basal polarity;GO:0002011,morphogenesis of an epithelial sheet;GO:0007269,neurotransmitter secretion;GO:0006836,neurotransmitter transport;GO:1903361,protein localization to basolateral plasma membrane;GO:0015031,protein transport	
GOGA2_HUMAN	Q08379	GOLGA2	Golgin subfamily A member 2	0.384120966	0.137666061	0.338367775	0.349568922	0.2608935135	0.3439683485	0.2608935135	0.3439683485	0.758481164437722	0.452984	0	1.31842430225848	0.453128	0	GO:0005801,cis-Golgi network;GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005794,Golgi apparatus;GO:0000137,Golgi cis cisterna;GO:0032580,Golgi cisterna membrane;GO:0000139,Golgi membrane;GO:0005874,microtubule;GO:0072686,mitotic spindle;GO:0000922,spindle pole	GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0061676,importin-alpha family protein binding;GO:0008017,microtubule binding;GO:0019901,protein kinase binding;GO:0019905,syntaxin binding	GO:0008356,asymmetric cell division;GO:0007098,centrosome cycle;GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0090166,Golgi disassembly;GO:0007030,Golgi organization;GO:0090161,Golgi ribbon formation;GO:0007020,microtubule nucleation;GO:0090307,mitotic spindle assembly;GO:0010507,negative regulation of autophagy;GO:0032091,negative regulation of protein binding;GO:0060050,positive regulation of protein glycosylation;GO:1904668,positive regulation of ubiquitin protein ligase activity;GO:0006486,protein glycosylation;GO:0051289,protein homotetramerization;GO:0015031,protein transport;GO:0051225,spindle assembly;GO:0090306,spindle assembly involved in meiosis	
IC1_HUMAN	P05155	SERPING1	Plasma protease C1 inhibitor	3.742495324	2.365700047	4.140360796	34.68648379	3.0540976855	19.413422293	3.0540976855	19.413422293	0.157318871418216	0.005833	-1	6.35651648772385	0.005885	1	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0031093,platelet alpha granule lumen	GO:0004867,serine-type endopeptidase inhibitor activity	GO:0008015,blood circulation;GO:0007597,blood coagulation, intrinsic pathway;GO:0006958,complement activation, classical pathway;GO:0042730,fibrinolysis;GO:0045087,innate immune response;GO:2000267,negative regulation of blood coagulation, intrinsic pathway;GO:0001869,negative regulation of complement activation, lectin pathway;GO:0010951,negative regulation of endopeptidase activity;GO:0002576,platelet degranulation;GO:0030449,regulation of complement activation;GO:0007568,aging;GO:0045916,negative regulation of complement activation;GO:0030193,regulation of blood coagulation	hsa:710,path:hsa04610,Complement and coagulation cascades;hsa:710,path:hsa05133,Pertussis
DHRS4_HUMAN	Q9BTZ2	DHRS4	Dehydrogenase/reductase SDR family member 4	0.270539803	0.561995607	0.385651297	0.457764634	0.416267705	0.4217079655	0.416267705	0.4217079655	0.987099459946056	0.437660	0	1.01306913900515	0.437472	0	GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005782,peroxisomal matrix;GO:0005778,peroxisomal membrane;GO:0005777,peroxisome	GO:0000253,3-keto sterol reductase activity;GO:0018455,alcohol dehydrogenase [NAD(P)+] activity;GO:0004090,carbonyl reductase (NADPH) activity;GO:0042802,identical protein binding;GO:0016655,oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0016491,oxidoreductase activity	GO:0006066,alcohol metabolic process;GO:0042180,cellular ketone metabolic process;GO:2000379,positive regulation of reactive oxygen species metabolic process;GO:0008104,protein localization;GO:0008202,steroid metabolic process	hsa:10901,path:hsa00830,Retinol metabolism;hsa:10901,path:hsa04146,Peroxisome
TENS1_HUMAN	Q9HBL0	TNS1	Tensin-1	1.910592365	1.392653571	2.497810275	11.13235379	1.651622968	6.8150820325	1.651622968	6.8150820325	0.242348215344098	0.031320	-1	4.12629405411611	0.031488	1	GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005925,focal adhesion	GO:0003779,actin binding;GO:0003723,RNA binding	GO:0035556,intracellular signal transduction;GO:0007044,cell-substrate junction assembly;GO:0010761,fibroblast migration	
DSRAD_HUMAN	P55265	ADAR	Double-stranded RNA-specific adenosine deaminase	2.83528052	1.892713599	3.825252133	8.687295742	2.3639970595	6.2562739375	2.3639970595	6.2562739375	0.377860222093256	0.118409	0	2.64648126881479	0.118724	0	GO:0005737,cytoplasm;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0044530,supraspliceosomal complex	GO:0003677,DNA binding;GO:0003726,double-stranded RNA adenosine deaminase activity;GO:0003725,double-stranded RNA binding;GO:0046872,metal ion binding;GO:0003723,RNA binding;GO:0008251,tRNA-specific adenosine deaminase activity;GO:0004000,adenosine deaminase activity	GO:0006382,adenosine to inosine editing;GO:0016553,base conversion or substitution editing;GO:0098586,cellular response to virus;GO:0051607,defense response to virus;GO:0060216,definitive hemopoiesis;GO:0030218,erythrocyte differentiation;GO:0002244,hematopoietic progenitor cell differentiation;GO:0061484,hematopoietic stem cell homeostasis;GO:0045087,innate immune response;GO:0035280,miRNA loading onto RISC involved in gene silencing by miRNA;GO:0006397,mRNA processing;GO:0043066,negative regulation of apoptotic process;GO:0044387,negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:1900369,negative regulation of RNA interference;GO:0060339,negative regulation of type I interferon-mediated signaling pathway;GO:0001649,osteoblast differentiation;GO:0045070,positive regulation of viral genome replication;GO:0031054,pre-miRNA processing;GO:0006611,protein export from nucleus;GO:0006606,protein import into nucleus;GO:0035455,response to interferon-alpha;GO:0009615,response to virus;GO:0006396,RNA processing;GO:0002566,somatic diversification of immune receptors via somatic mutation;GO:0060337,type I interferon signaling pathway	hsa:103,path:hsa04623,Cytosolic DNA-sensing pathway;hsa:103,path:hsa05162,Measles;hsa:103,path:hsa05164,Influenza A
ECHB_HUMAN	P55084	HADHB	Trifunctional enzyme subunit beta, mitochondrial	13.13235144	15.46604554	13.73579594	12.55692664	14.29919849	13.14636129	14.29919849	13.14636129	1.08769249335	0.405670	0	0.919377495122805	0.405414	0	GO:0005783,endoplasmic reticulum;GO:0005740,mitochondrial envelope;GO:0005743,mitochondrial inner membrane;GO:0042645,mitochondrial nucleoid;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion	GO:0003857,3-hydroxyacyl-CoA dehydrogenase activity;GO:0003988,acetyl-CoA C-acyltransferase activity;GO:0050633,acetyl-CoA C-myristoyltransferase activity;GO:0004300,enoyl-CoA hydratase activity;GO:0003723,RNA binding;GO:0016747,transferase activity, transferring acyl groups other than amino-acyl groups	GO:0035965,cardiolipin acyl-chain remodeling;GO:0006635,fatty acid beta-oxidation	hsa:3032,path:hsa00062,Fatty acid elongation;hsa:3032,path:hsa00071,Fatty acid degradation;hsa:3032,path:hsa00280,Valine, leucine and isoleucine degradation
PPM1F_HUMAN	P49593	PPM1F	Protein phosphatase 1F	0.56625909	0.515057423	0.703875125	3.815331234	0.5406582565	2.2596031795	0.5406582565	2.2596031795	0.239271329322362	0.029968	-1	4.17935572486721	0.030131	1	GO:0005829,cytosol;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0032991,protein-containing complex	GO:0033192,calmodulin-dependent protein phosphatase activity;GO:0046872,metal ion binding;GO:0106306,protein serine phosphatase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0106307,protein threonine phosphatase activity;GO:0008138,protein tyrosine/serine/threonine phosphatase activity	GO:0035690,cellular response to drug;GO:0016576,histone dephosphorylation;GO:0097193,intrinsic apoptotic signaling pathway;GO:2000048,negative regulation of cell-cell adhesion mediated by cadherin;GO:0033137,negative regulation of peptidyl-serine phosphorylation;GO:0006469,negative regulation of protein kinase activity;GO:0044387,negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0051224,negative regulation of protein transport;GO:0045892,negative regulation of transcription, DNA-templated;GO:0070262,peptidyl-serine dephosphorylation;GO:0035970,peptidyl-threonine dephosphorylation;GO:0030335,positive regulation of cell migration;GO:0010811,positive regulation of cell-substrate adhesion;GO:0050921,positive regulation of chemotaxis;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0010634,positive regulation of epithelial cell migration;GO:0051894,positive regulation of focal adhesion assembly;GO:0010628,positive regulation of gene expression;GO:0045927,positive regulation of growth;GO:0051496,positive regulation of stress fiber assembly;GO:0006470,protein dephosphorylation;GO:1903827,regulation of cellular protein localization	
MGMT_HUMAN	P16455	MGMT	Methylated-DNA--protein-cysteine methyltransferase	0.293863056	0.199352232	0.034938362	0.011723725	0.246607644	0.0233310435	0.246607644	0.0233310435	10.5699363168218	0.015568	1	0.0946079493788927	0.015376	-1	GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0009008,DNA-methyltransferase activity;GO:0046872,metal ion binding;GO:0003908,methylated-DNA-[protein]-cysteine S-methyltransferase activity;GO:0008168,methyltransferase activity;GO:0005509,calcium ion binding	GO:0006307,DNA dealkylation involved in DNA repair;GO:0006266,DNA ligation;GO:0006281,DNA repair;GO:0043066,negative regulation of apoptotic process;GO:2000781,positive regulation of double-strand break repair;GO:0071479,cellular response to ionizing radiation;GO:0071407,cellular response to organic cyclic compound;GO:0034599,cellular response to oxidative stress;GO:0060644,mammary gland epithelial cell differentiation;GO:0032259,methylation;GO:0060548,negative regulation of cell death;GO:0045739,positive regulation of DNA repair;GO:0043281,regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0042493,response to drug;GO:0045471,response to ethanol;GO:0051593,response to folic acid;GO:0009636,response to toxic substance	
RAE1L_HUMAN	P78406	RAE1	mRNA export factor	0.41728467	0.08251342	0.451511488	0.187080115	0.249899045	0.3192958015	0.249899045	0.3192958015	0.782656846178417	0.472027	0	1.27769916647741	0.472149	0	GO:0005737,cytoplasm;GO:0001650,fibrillar center;GO:0043657,host cell;GO:0097431,mitotic spindle pole;GO:0005635,nuclear envelope;GO:0005643,nuclear pore;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000922,spindle pole	GO:0008017,microtubule binding;GO:0003723,RNA binding;GO:0043130,ubiquitin binding	GO:0007049,cell cycle;GO:0051301,cell division;GO:0075733,intracellular transport of virus;GO:0006406,mRNA export from nucleus;GO:0016925,protein sumoylation;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0060236,regulation of mitotic spindle organization;GO:0006405,RNA export from nucleus;GO:0000972,transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription;GO:0071407,cellular response to organic cyclic compound	hsa:8480,path:hsa03013,RNA transport;hsa:8480,path:hsa05164,Influenza A
HLAA_HUMAN	P04439	HLA-A	HLA class I histocompatibility antigen, A alpha chain	11.73191148	8.161887232	17.74886759	10.52512536	9.946899356	14.136996475	9.946899356	14.136996475	0.703607684531166	0.407923	0	1.4212465582526	0.408116	0	GO:0009986,cell surface;GO:0031901,early endosome membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0000139,Golgi membrane;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0042612,MHC class I protein complex;GO:0032398,MHC class Ib protein complex;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0030667,secretory granule membrane;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0030666,endocytic vesicle membrane;GO:0001772,immunological synapse;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0042613,MHC class II protein complex;GO:0032588,trans-Golgi network membrane;GO:0030658,transport vesicle membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0010008,endosome membrane;GO:0005882,intermediate filament;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0005797,Golgi medial cisterna;GO:0042824,MHC class I peptide loading complex;GO:0035577,azurophil granule membrane;GO:0033106,cis-Golgi network membrane;GO:0005769,early endosome;GO:0031527,filopodium membrane;GO:0005771,multivesicular body	GO:0030881,beta-2-microglobulin binding;GO:0042288,MHC class I protein binding;GO:0046703,natural killer cell lectin-like receptor binding;GO:0042605,peptide antigen binding;GO:0005102,signaling receptor binding;GO:0042608,T cell receptor binding;GO:0051087,chaperone binding;GO:0046977,TAP binding;GO:0023026,MHC class II protein complex binding;GO:0032395,MHC class II receptor activity;GO:0030247,polysaccharide binding;GO:0042609,CD4 receptor binding;GO:0005200,structural constituent of cytoskeleton;GO:0042610,CD8 receptor binding;GO:0003723,RNA binding;GO:0062061,TAP complex binding;GO:0071889,14-3-3 protein binding;GO:0046978,TAP1 binding;GO:0046979,TAP2 binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:1990405,protein antigen binding;GO:0015643,toxic substance binding;GO:0008134,transcription factor binding;GO:0031625,ubiquitin protein ligase binding;GO:0046872,metal ion binding	GO:0002250,adaptive immune response;GO:0019731,antibacterial humoral response;GO:0002476,antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0002477,antigen processing and presentation of exogenous peptide antigen via MHC class Ib;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0036037,CD8-positive, alpha-beta T cell activation;GO:0050830,defense response to Gram-positive bacterium;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0002519,natural killer cell tolerance induction;GO:0045953,negative regulation of natural killer cell mediated cytotoxicity;GO:0001815,positive regulation of antibody-dependent cellular cytotoxicity;GO:2001187,positive regulation of CD8-positive, alpha-beta T cell activation;GO:2000566,positive regulation of CD8-positive, alpha-beta T cell proliferation;GO:0002639,positive regulation of immunoglobulin production;GO:0032736,positive regulation of interleukin-13 production;GO:0032753,positive regulation of interleukin-4 production;GO:0002729,positive regulation of natural killer cell cytokine production;GO:0045954,positive regulation of natural killer cell mediated cytotoxicity;GO:0002717,positive regulation of natural killer cell mediated immunity;GO:0032819,positive regulation of natural killer cell proliferation;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:0032759,positive regulation of TRAIL production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0042270,protection from natural killer cell mediated cytotoxicity;GO:0050776,regulation of immune response;GO:0002715,regulation of natural killer cell mediated immunity;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process;GO:0002486,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006952,defense response;GO:0016045,detection of bacterium;GO:0006955,immune response;GO:0043312,neutrophil degranulation;GO:2001198,regulation of dendritic cell differentiation;GO:0032655,regulation of interleukin-12 production;GO:0032675,regulation of interleukin-6 production;GO:0002667,regulation of T cell anergy;GO:0002491,antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002504,antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0050890,cognition;GO:0002469,myeloid dendritic cell antigen processing and presentation;GO:0002503,peptide antigen assembly with MHC class II protein complex;GO:2000516,positive regulation of CD4-positive, alpha-beta T cell activation;GO:0032831,positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0043382,positive regulation of memory T cell differentiation;GO:0045622,regulation of T-helper cell differentiation;GO:0050852,T cell receptor signaling pathway;GO:0002399,MHC class II protein complex assembly;GO:2001190,positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0042102,positive regulation of T cell proliferation;GO:0032729,positive regulation of interferon-gamma production;GO:0050870,positive regulation of T cell activation;GO:0008544,epidermis development;GO:0006959,humoral immune response;GO:0002437,inflammatory response to antigenic stimulus;GO:0030225,macrophage differentiation;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0032689,negative regulation of interferon-gamma production;GO:0042130,negative regulation of T cell proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0033674,positive regulation of kinase activity;GO:0043410,positive regulation of MAPK cascade;GO:0045657,positive regulation of monocyte differentiation;GO:0001934,positive regulation of protein phosphorylation;GO:0002842,positive regulation of T cell mediated immune response to tumor cell;GO:0045893,positive regulation of transcription, DNA-templated;GO:0046598,positive regulation of viral entry into host cell;GO:0051262,protein tetramerization;GO:0032653,regulation of interleukin-10 production;GO:0032673,regulation of interleukin-4 production;GO:0007165,signal transduction;GO:0042088,T-helper 1 type immune response;GO:0002587,negative regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0045580,regulation of T cell differentiation;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002485,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent;GO:0042590,antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:2000568,positive regulation of memory T cell activation;GO:0002726,positive regulation of T cell cytokine production;GO:0016567,protein ubiquitination;GO:0001913,T cell mediated cytotoxicity;GO:0002419,T cell mediated cytotoxicity directed against tumor cell target;GO:0002728,negative regulation of natural killer cell cytokine production;GO:0043322,negative regulation of natural killer cell degranulation;GO:1901215,negative regulation of neuron death;GO:0002725,negative regulation of T cell cytokine production;GO:0043323,positive regulation of natural killer cell degranulation;GO:0071346,cellular response to interferon-gamma;GO:0006968,cellular defense response;GO:0002767,immune response-inhibiting cell surface receptor signaling pathway;GO:0016525,negative regulation of angiogenesis;GO:2001199,negative regulation of dendritic cell differentiation;GO:0070317,negative regulation of G0 to G1 transition;GO:0050777,negative regulation of immune response;GO:0051898,negative regulation of protein kinase B signaling;GO:0001915,negative regulation of T cell mediated cytotoxicity;GO:0002451,peripheral B cell tolerance induction;GO:2000774,positive regulation of cellular senescence;GO:2000353,positive regulation of endothelial cell apoptotic process;GO:0032735,positive regulation of interleukin-12 production;GO:0060907,positive regulation of macrophage cytokine production;GO:0045591,positive regulation of regulatory T cell differentiation;GO:0002666,positive regulation of T cell tolerance induction;GO:0002645,positive regulation of tolerance induction;GO:0070207,protein homotrimerization;GO:0019882,antigen processing and presentation;GO:0002344,B cell affinity maturation;GO:0046635,positive regulation of alpha-beta T cell activation;GO:0002579,positive regulation of antigen processing and presentation;GO:0002827,positive regulation of T-helper 1 type immune response	hsa:3133,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3133,path:hsa04144,Endocytosis;hsa:3133,path:hsa04145,Phagosome;hsa:3133,path:hsa04218,Cellular senescence;hsa:3133,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3133,path:hsa04612,Antigen processing and presentation;hsa:3133,path:hsa05203,Viral carcinogenesis;hsa:3133,path:hsa05320,Autoimmune thyroid disease;hsa:3133,path:hsa05330,Allograft rejection;hsa:3133,path:hsa05332,Graft-versus-host disease;hsa:3133,path:hsa05416,Viral myocarditis;hsa:3133,path:hsa04940,Type I diabetes mellitus;hsa:3133,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3133,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3133,path:hsa05168,Herpes simplex virus 1 infection;hsa:3133,path:hsa05163,Human cytomegalovirus infection;hsa:3133,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3133,path:hsa05169,Epstein-Barr virus infection;hsa:3133,path:hsa05165,Human papillomavirus infection;hsa:3106,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3106,path:hsa04144,Endocytosis;hsa:3106,path:hsa04145,Phagosome;hsa:3106,path:hsa04218,Cellular senescence;hsa:3106,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3106,path:hsa04612,Antigen processing and presentation;hsa:3106,path:hsa05203,Viral carcinogenesis;hsa:3106,path:hsa05320,Autoimmune thyroid disease;hsa:3106,path:hsa05330,Allograft rejection;hsa:3106,path:hsa05332,Graft-versus-host disease;hsa:3106,path:hsa05416,Viral myocarditis;hsa:3106,path:hsa04940,Type I diabetes mellitus;hsa:3106,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3106,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3106,path:hsa05168,Herpes simplex virus 1 infection;hsa:3106,path:hsa05163,Human cytomegalovirus infection;hsa:3106,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3106,path:hsa05169,Epstein-Barr virus infection;hsa:3106,path:hsa05165,Human papillomavirus infection;hsa:3122,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3122,path:hsa04145,Phagosome;hsa:3122,path:hsa04640,Hematopoietic cell lineage;hsa:3122,path:hsa04612,Antigen processing and presentation;hsa:3122,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3122,path:hsa04659,Th17 cell differentiation;hsa:3122,path:hsa04672,Intestinal immune network for IgA production;hsa:3122,path:hsa05310,Asthma;hsa:3122,path:hsa05322,Systemic lupus erythematosus;hsa:3122,path:hsa05323,Rheumatoid arthritis;hsa:3122,path:hsa05320,Autoimmune thyroid disease;hsa:3122,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3122,path:hsa05330,Allograft rejection;hsa:3122,path:hsa05332,Graft-versus-host disease;hsa:3122,path:hsa05416,Viral myocarditis;hsa:3122,path:hsa04940,Type I diabetes mellitus;hsa:3122,path:hsa05150,Staphylococcus aureus infection;hsa:3122,path:hsa05152,Tuberculosis;hsa:3122,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3122,path:hsa05164,Influenza A;hsa:3122,path:hsa05168,Herpes simplex virus 1 infection;hsa:3122,path:hsa05169,Epstein-Barr virus infection;hsa:3122,path:hsa05145,Toxoplasmosis;hsa:3122,path:hsa05140,Leishmaniasis;hsa:3109,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3109,path:hsa04145,Phagosome;hsa:3109,path:hsa04640,Hematopoietic cell lineage;hsa:3109,path:hsa04612,Antigen processing and presentation;hsa:3109,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3109,path:hsa04659,Th17 cell differentiation;hsa:3109,path:hsa04672,Intestinal immune network for IgA production;hsa:3109,path:hsa05310,Asthma;hsa:3109,path:hsa05322,Systemic lupus erythematosus;hsa:3109,path:hsa05323,Rheumatoid arthritis;hsa:3109,path:hsa05320,Autoimmune thyroid disease;hsa:3109,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3109,path:hsa05330,Allograft rejection;hsa:3109,path:hsa05332,Graft-versus-host disease;hsa:3109,path:hsa05416,Viral myocarditis;hsa:3109,path:hsa04940,Type I diabetes mellitus;hsa:3109,path:hsa05150,Staphylococcus aureus infection;hsa:3109,path:hsa05152,Tuberculosis;hsa:3109,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3109,path:hsa05164,Influenza A;hsa:3109,path:hsa05168,Herpes simplex virus 1 infection;hsa:3109,path:hsa05169,Epstein-Barr virus infection;hsa:3109,path:hsa05145,Toxoplasmosis;hsa:3109,path:hsa05140,Leishmaniasis;hsa:3115,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3115,path:hsa04145,Phagosome;hsa:3115,path:hsa04640,Hematopoietic cell lineage;hsa:3115,path:hsa04612,Antigen processing and presentation;hsa:3115,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3115,path:hsa04659,Th17 cell differentiation;hsa:3115,path:hsa04672,Intestinal immune network for IgA production;hsa:3115,path:hsa05310,Asthma;hsa:3115,path:hsa05322,Systemic lupus erythematosus;hsa:3115,path:hsa05323,Rheumatoid arthritis;hsa:3115,path:hsa05320,Autoimmune thyroid disease;hsa:3115,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3115,path:hsa05330,Allograft rejection;hsa:3115,path:hsa05332,Graft-versus-host disease;hsa:3115,path:hsa05416,Viral myocarditis;hsa:3115,path:hsa04940,Type I diabetes mellitus;hsa:3115,path:hsa05150,Staphylococcus aureus infection;hsa:3115,path:hsa05152,Tuberculosis;hsa:3115,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3115,path:hsa05164,Influenza A;hsa:3115,path:hsa05168,Herpes simplex virus 1 infection;hsa:3115,path:hsa05169,Epstein-Barr virus infection;hsa:3115,path:hsa05145,Toxoplasmosis;hsa:3115,path:hsa05140,Leishmaniasis;hsa:3123,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3123,path:hsa04145,Phagosome;hsa:3123,path:hsa04640,Hematopoietic cell lineage;hsa:3123,path:hsa04612,Antigen processing and presentation;hsa:3123,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3123,path:hsa04659,Th17 cell differentiation;hsa:3123,path:hsa04672,Intestinal immune network for IgA production;hsa:3123,path:hsa05310,Asthma;hsa:3123,path:hsa05322,Systemic lupus erythematosus;hsa:3123,path:hsa05323,Rheumatoid arthritis;hsa:3123,path:hsa05320,Autoimmune thyroid disease;hsa:3123,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3123,path:hsa05330,Allograft rejection;hsa:3123,path:hsa05332,Graft-versus-host disease;hsa:3123,path:hsa05416,Viral myocarditis;hsa:3123,path:hsa04940,Type I diabetes mellitus;hsa:3123,path:hsa05150,Staphylococcus aureus infection;hsa:3123,path:hsa05152,Tuberculosis;hsa:3123,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3123,path:hsa05164,Influenza A;hsa:3123,path:hsa05168,Herpes simplex virus 1 infection;hsa:3123,path:hsa05169,Epstein-Barr virus infection;hsa:3123,path:hsa05145,Toxoplasmosis;hsa:3123,path:hsa05140,Leishmaniasis;hsa:3111,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3111,path:hsa04145,Phagosome;hsa:3111,path:hsa04640,Hematopoietic cell lineage;hsa:3111,path:hsa04612,Antigen processing and presentation;hsa:3111,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3111,path:hsa04659,Th17 cell differentiation;hsa:3111,path:hsa04672,Intestinal immune network for IgA production;hsa:3111,path:hsa05310,Asthma;hsa:3111,path:hsa05322,Systemic lupus erythematosus;hsa:3111,path:hsa05323,Rheumatoid arthritis;hsa:3111,path:hsa05320,Autoimmune thyroid disease;hsa:3111,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3111,path:hsa05330,Allograft rejection;hsa:3111,path:hsa05332,Graft-versus-host disease;hsa:3111,path:hsa05416,Viral myocarditis;hsa:3111,path:hsa04940,Type I diabetes mellitus;hsa:3111,path:hsa05150,Staphylococcus aureus infection;hsa:3111,path:hsa05152,Tuberculosis;hsa:3111,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3111,path:hsa05164,Influenza A;hsa:3111,path:hsa05168,Herpes simplex virus 1 infection;hsa:3111,path:hsa05169,Epstein-Barr virus infection;hsa:3111,path:hsa05145,Toxoplasmosis;hsa:3111,path:hsa05140,Leishmaniasis;hsa:3112,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3112,path:hsa04145,Phagosome;hsa:3112,path:hsa04640,Hematopoietic cell lineage;hsa:3112,path:hsa04612,Antigen processing and presentation;hsa:3112,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3112,path:hsa04659,Th17 cell differentiation;hsa:3112,path:hsa04672,Intestinal immune network for IgA production;hsa:3112,path:hsa05310,Asthma;hsa:3112,path:hsa05322,Systemic lupus erythematosus;hsa:3112,path:hsa05323,Rheumatoid arthritis;hsa:3112,path:hsa05320,Autoimmune thyroid disease;hsa:3112,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3112,path:hsa05330,Allograft rejection;hsa:3112,path:hsa05332,Graft-versus-host disease;hsa:3112,path:hsa05416,Viral myocarditis;hsa:3112,path:hsa04940,Type I diabetes mellitus;hsa:3112,path:hsa05150,Staphylococcus aureus infection;hsa:3112,path:hsa05152,Tuberculosis;hsa:3112,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3112,path:hsa05164,Influenza A;hsa:3112,path:hsa05168,Herpes simplex virus 1 infection;hsa:3112,path:hsa05169,Epstein-Barr virus infection;hsa:3112,path:hsa05145,Toxoplasmosis;hsa:3112,path:hsa05140,Leishmaniasis;hsa:3105,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3105,path:hsa04144,Endocytosis;hsa:3105,path:hsa04145,Phagosome;hsa:3105,path:hsa04218,Cellular senescence;hsa:3105,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3105,path:hsa04612,Antigen processing and presentation;hsa:3105,path:hsa05203,Viral carcinogenesis;hsa:3105,path:hsa05320,Autoimmune thyroid disease;hsa:3105,path:hsa05330,Allograft rejection;hsa:3105,path:hsa05332,Graft-versus-host disease;hsa:3105,path:hsa05416,Viral myocarditis;hsa:3105,path:hsa04940,Type I diabetes mellitus;hsa:3105,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3105,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3105,path:hsa05168,Herpes simplex virus 1 infection;hsa:3105,path:hsa05163,Human cytomegalovirus infection;hsa:3105,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3105,path:hsa05169,Epstein-Barr virus infection;hsa:3105,path:hsa05165,Human papillomavirus infection;hsa:3134,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3134,path:hsa04144,Endocytosis;hsa:3134,path:hsa04145,Phagosome;hsa:3134,path:hsa04218,Cellular senescence;hsa:3134,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3134,path:hsa04612,Antigen processing and presentation;hsa:3134,path:hsa05203,Viral carcinogenesis;hsa:3134,path:hsa05320,Autoimmune thyroid disease;hsa:3134,path:hsa05330,Allograft rejection;hsa:3134,path:hsa05332,Graft-versus-host disease;hsa:3134,path:hsa05416,Viral myocarditis;hsa:3134,path:hsa04940,Type I diabetes mellitus;hsa:3134,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3134,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3134,path:hsa05168,Herpes simplex virus 1 infection;hsa:3134,path:hsa05163,Human cytomegalovirus infection;hsa:3134,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3134,path:hsa05169,Epstein-Barr virus infection;hsa:3134,path:hsa05165,Human papillomavirus infection;hsa:3119,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3119,path:hsa04145,Phagosome;hsa:3119,path:hsa04640,Hematopoietic cell lineage;hsa:3119,path:hsa04612,Antigen processing and presentation;hsa:3119,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3119,path:hsa04659,Th17 cell differentiation;hsa:3119,path:hsa04672,Intestinal immune network for IgA production;hsa:3119,path:hsa05310,Asthma;hsa:3119,path:hsa05322,Systemic lupus erythematosus;hsa:3119,path:hsa05323,Rheumatoid arthritis;hsa:3119,path:hsa05320,Autoimmune thyroid disease;hsa:3119,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3119,path:hsa05330,Allograft rejection;hsa:3119,path:hsa05332,Graft-versus-host disease;hsa:3119,path:hsa05416,Viral myocarditis;hsa:3119,path:hsa04940,Type I diabetes mellitus;hsa:3119,path:hsa05150,Staphylococcus aureus infection;hsa:3119,path:hsa05152,Tuberculosis;hsa:3119,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3119,path:hsa05164,Influenza A;hsa:3119,path:hsa05168,Herpes simplex virus 1 infection;hsa:3119,path:hsa05169,Epstein-Barr virus infection;hsa:3119,path:hsa05145,Toxoplasmosis;hsa:3119,path:hsa05140,Leishmaniasis;hsa:3113,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3113,path:hsa04145,Phagosome;hsa:3113,path:hsa04640,Hematopoietic cell lineage;hsa:3113,path:hsa04612,Antigen processing and presentation;hsa:3113,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3113,path:hsa04659,Th17 cell differentiation;hsa:3113,path:hsa04672,Intestinal immune network for IgA production;hsa:3113,path:hsa05310,Asthma;hsa:3113,path:hsa05322,Systemic lupus erythematosus;hsa:3113,path:hsa05323,Rheumatoid arthritis;hsa:3113,path:hsa05320,Autoimmune thyroid disease;hsa:3113,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3113,path:hsa05330,Allograft rejection;hsa:3113,path:hsa05332,Graft-versus-host disease;hsa:3113,path:hsa05416,Viral myocarditis;hsa:3113,path:hsa04940,Type I diabetes mellitus;hsa:3113,path:hsa05150,Staphylococcus aureus infection;hsa:3113,path:hsa05152,Tuberculosis;hsa:3113,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3113,path:hsa05164,Influenza A;hsa:3113,path:hsa05168,Herpes simplex virus 1 infection;hsa:3113,path:hsa05169,Epstein-Barr virus infection;hsa:3113,path:hsa05145,Toxoplasmosis;hsa:3113,path:hsa05140,Leishmaniasis;hsa:3125,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3125,path:hsa04145,Phagosome;hsa:3125,path:hsa04640,Hematopoietic cell lineage;hsa:3125,path:hsa04612,Antigen processing and presentation;hsa:3125,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3125,path:hsa04659,Th17 cell differentiation;hsa:3125,path:hsa04672,Intestinal immune network for IgA production;hsa:3125,path:hsa05310,Asthma;hsa:3125,path:hsa05322,Systemic lupus erythematosus;hsa:3125,path:hsa05323,Rheumatoid arthritis;hsa:3125,path:hsa05320,Autoimmune thyroid disease;hsa:3125,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3125,path:hsa05330,Allograft rejection;hsa:3125,path:hsa05332,Graft-versus-host disease;hsa:3125,path:hsa05416,Viral myocarditis;hsa:3125,path:hsa04940,Type I diabetes mellitus;hsa:3125,path:hsa05150,Staphylococcus aureus infection;hsa:3125,path:hsa05152,Tuberculosis;hsa:3125,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3125,path:hsa05164,Influenza A;hsa:3125,path:hsa05168,Herpes simplex virus 1 infection;hsa:3125,path:hsa05169,Epstein-Barr virus infection;hsa:3125,path:hsa05145,Toxoplasmosis;hsa:3125,path:hsa05140,Leishmaniasis;hsa:3126,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3126,path:hsa04145,Phagosome;hsa:3126,path:hsa04640,Hematopoietic cell lineage;hsa:3126,path:hsa04612,Antigen processing and presentation;hsa:3126,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3126,path:hsa04659,Th17 cell differentiation;hsa:3126,path:hsa04672,Intestinal immune network for IgA production;hsa:3126,path:hsa05310,Asthma;hsa:3126,path:hsa05322,Systemic lupus erythematosus;hsa:3126,path:hsa05323,Rheumatoid arthritis;hsa:3126,path:hsa05320,Autoimmune thyroid disease;hsa:3126,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3126,path:hsa05330,Allograft rejection;hsa:3126,path:hsa05332,Graft-versus-host disease;hsa:3126,path:hsa05416,Viral myocarditis;hsa:3126,path:hsa04940,Type I diabetes mellitus;hsa:3126,path:hsa05150,Staphylococcus aureus infection;hsa:3126,path:hsa05152,Tuberculosis;hsa:3126,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3126,path:hsa05164,Influenza A;hsa:3126,path:hsa05168,Herpes simplex virus 1 infection;hsa:3126,path:hsa05169,Epstein-Barr virus infection;hsa:3126,path:hsa05145,Toxoplasmosis;hsa:3126,path:hsa05140,Leishmaniasis;hsa:3107,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3107,path:hsa04144,Endocytosis;hsa:3107,path:hsa04145,Phagosome;hsa:3107,path:hsa04218,Cellular senescence;hsa:3107,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3107,path:hsa04612,Antigen processing and presentation;hsa:3107,path:hsa05203,Viral carcinogenesis;hsa:3107,path:hsa05320,Autoimmune thyroid disease;hsa:3107,path:hsa05330,Allograft rejection;hsa:3107,path:hsa05332,Graft-versus-host disease;hsa:3107,path:hsa05416,Viral myocarditis;hsa:3107,path:hsa04940,Type I diabetes mellitus;hsa:3107,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3107,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3107,path:hsa05168,Herpes simplex virus 1 infection;hsa:3107,path:hsa05163,Human cytomegalovirus infection;hsa:3107,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3107,path:hsa05169,Epstein-Barr virus infection;hsa:3107,path:hsa05165,Human papillomavirus infection;hsa:3135,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3135,path:hsa04144,Endocytosis;hsa:3135,path:hsa04145,Phagosome;hsa:3135,path:hsa04218,Cellular senescence;hsa:3135,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3135,path:hsa04612,Antigen processing and presentation;hsa:3135,path:hsa05203,Viral carcinogenesis;hsa:3135,path:hsa05320,Autoimmune thyroid disease;hsa:3135,path:hsa05330,Allograft rejection;hsa:3135,path:hsa05332,Graft-versus-host disease;hsa:3135,path:hsa05416,Viral myocarditis;hsa:3135,path:hsa04940,Type I diabetes mellitus;hsa:3135,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3135,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3135,path:hsa05168,Herpes simplex virus 1 infection;hsa:3135,path:hsa05163,Human cytomegalovirus infection;hsa:3135,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3135,path:hsa05169,Epstein-Barr virus infection;hsa:3135,path:hsa05165,Human papillomavirus infection;hsa:3127,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3127,path:hsa04145,Phagosome;hsa:3127,path:hsa04640,Hematopoietic cell lineage;hsa:3127,path:hsa04612,Antigen processing and presentation;hsa:3127,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3127,path:hsa04659,Th17 cell differentiation;hsa:3127,path:hsa04672,Intestinal immune network for IgA production;hsa:3127,path:hsa05310,Asthma;hsa:3127,path:hsa05322,Systemic lupus erythematosus;hsa:3127,path:hsa05323,Rheumatoid arthritis;hsa:3127,path:hsa05320,Autoimmune thyroid disease;hsa:3127,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3127,path:hsa05330,Allograft rejection;hsa:3127,path:hsa05332,Graft-versus-host disease;hsa:3127,path:hsa05416,Viral myocarditis;hsa:3127,path:hsa04940,Type I diabetes mellitus;hsa:3127,path:hsa05150,Staphylococcus aureus infection;hsa:3127,path:hsa05152,Tuberculosis;hsa:3127,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3127,path:hsa05164,Influenza A;hsa:3127,path:hsa05168,Herpes simplex virus 1 infection;hsa:3127,path:hsa05169,Epstein-Barr virus infection;hsa:3127,path:hsa05145,Toxoplasmosis;hsa:3127,path:hsa05140,Leishmaniasis;hsa:3118,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3118,path:hsa04145,Phagosome;hsa:3118,path:hsa04640,Hematopoietic cell lineage;hsa:3118,path:hsa04612,Antigen processing and presentation;hsa:3118,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3118,path:hsa04659,Th17 cell differentiation;hsa:3118,path:hsa04672,Intestinal immune network for IgA production;hsa:3118,path:hsa05310,Asthma;hsa:3118,path:hsa05322,Systemic lupus erythematosus;hsa:3118,path:hsa05323,Rheumatoid arthritis;hsa:3118,path:hsa05320,Autoimmune thyroid disease;hsa:3118,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3118,path:hsa05330,Allograft rejection;hsa:3118,path:hsa05332,Graft-versus-host disease;hsa:3118,path:hsa05416,Viral myocarditis;hsa:3118,path:hsa04940,Type I diabetes mellitus;hsa:3118,path:hsa05150,Staphylococcus aureus infection;hsa:3118,path:hsa05152,Tuberculosis;hsa:3118,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3118,path:hsa05164,Influenza A;hsa:3118,path:hsa05168,Herpes simplex virus 1 infection;hsa:3118,path:hsa05169,Epstein-Barr virus infection;hsa:3118,path:hsa05145,Toxoplasmosis;hsa:3118,path:hsa05140,Leishmaniasis;hsa:3117,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3117,path:hsa04145,Phagosome;hsa:3117,path:hsa04640,Hematopoietic cell lineage;hsa:3117,path:hsa04612,Antigen processing and presentation;hsa:3117,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3117,path:hsa04659,Th17 cell differentiation;hsa:3117,path:hsa04672,Intestinal immune network for IgA production;hsa:3117,path:hsa05310,Asthma;hsa:3117,path:hsa05322,Systemic lupus erythematosus;hsa:3117,path:hsa05323,Rheumatoid arthritis;hsa:3117,path:hsa05320,Autoimmune thyroid disease;hsa:3117,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3117,path:hsa05330,Allograft rejection;hsa:3117,path:hsa05332,Graft-versus-host disease;hsa:3117,path:hsa05416,Viral myocarditis;hsa:3117,path:hsa04940,Type I diabetes mellitus;hsa:3117,path:hsa05150,Staphylococcus aureus infection;hsa:3117,path:hsa05152,Tuberculosis;hsa:3117,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3117,path:hsa05164,Influenza A;hsa:3117,path:hsa05168,Herpes simplex virus 1 infection;hsa:3117,path:hsa05169,Epstein-Barr virus infection;hsa:3117,path:hsa05145,Toxoplasmosis;hsa:3117,path:hsa05140,Leishmaniasis
ACTY_HUMAN	P42025	ACTR1B	Beta-centractin	0.367761245	0.086423349	0.23924329	0.240113424	0.227092297	0.239678357	0.227092297	0.239678357	0.947487707452868	0.451298	0	1.05542266367582	0.451140	0	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005869,dynactin complex;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0015630,microtubule cytoskeleton;GO:0034774,secretory granule lumen	GO:0005524,ATP binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0043312,neutrophil degranulation	
EPB42_HUMAN	P16452	EPB42	Protein 4.2	2.23809604	5.231327785	0.900776407	25.82182037	3.7347119125	13.3612983885	3.7347119125	13.3612983885	0.27951714001945	0.050122	0	3.57759813917106	0.050341	0	GO:0030863,cortical cytoskeleton;GO:0005856,cytoskeleton;GO:0005886,plasma membrane	GO:0005524,ATP binding;GO:0003810,protein-glutamine gamma-glutamyltransferase activity;GO:0005200,structural constituent of cytoskeleton	GO:0000902,cell morphogenesis;GO:0043249,erythrocyte maturation;GO:0020027,hemoglobin metabolic process;GO:0055072,iron ion homeostasis;GO:0018149,peptide cross-linking;GO:0008360,regulation of cell shape;GO:0048536,spleen development	
FLOT2_HUMAN	Q14254	FLOT2	Flotillin-2	2.2542946	3.136970844	3.365517802	7.411767561	2.695632722	5.3886426815	2.695632722	5.3886426815	0.500243360216572	0.225363	0	1.99902703269678	0.225692	0	GO:0005912,adherens junction;GO:0016323,basolateral plasma membrane;GO:0005901,caveola;GO:0044291,cell-cell contact zone;GO:0031410,cytoplasmic vesicle;GO:0030139,endocytic vesicle;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0016600,flotillin complex;GO:0005925,focal adhesion;GO:0043231,intracellular membrane-bounded organelle;GO:0030027,lamellipodium;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0001931,uropod;GO:0031982,vesicle;GO:0002080,acrosomal membrane;GO:0099029,anchored component of presynaptic active zone membrane;GO:0032839,dendrite cytoplasm;GO:0098978,glutamatergic synapse	GO:0035255,ionotropic glutamate receptor binding;GO:0002020,protease binding	GO:0007155,cell adhesion;GO:0008544,epidermis development;GO:0001765,membrane raft assembly;GO:1902992,negative regulation of amyloid precursor protein catabolic process;GO:0010629,negative regulation of gene expression;GO:1903905,positive regulation of establishment of T cell polarity;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0072659,protein localization to plasma membrane;GO:0044860,protein localization to plasma membrane raft;GO:0050821,protein stabilization;GO:0045661,regulation of myoblast differentiation;GO:0060544,regulation of necroptotic process;GO:0098937,anterograde dendritic transport;GO:0099072,regulation of postsynaptic membrane neurotransmitter receptor levels	hsa:2319,path:hsa04910,Insulin signaling pathway
TIM50_HUMAN	Q3ZCQ8	TIMM50	Mitochondrial import inner membrane translocase subunit TIM50	0.290146442	0.183168896	0.451309565	0.179418018	0.236657669	0.3153637915	0.236657669	0.3153637915	0.750427523319525	0.446528	0	1.33257372487684	0.446679	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005744,TIM23 mitochondrial import inner membrane translocase complex	GO:0005134,interleukin-2 receptor binding;GO:0004721,phosphoprotein phosphatase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0004725,protein tyrosine phosphatase activity;GO:0043021,ribonucleoprotein complex binding;GO:0003723,RNA binding	GO:0007006,mitochondrial membrane organization;GO:0006470,protein dephosphorylation;GO:0030150,protein import into mitochondrial matrix;GO:0001836,release of cytochrome c from mitochondria;GO:0015031,protein transport	
PRDX1_HUMAN	Q06830	PRDX1	Peroxiredoxin-1	311.0031401	417.1408384	49.78075599	26.66193977	364.07198925	38.22134788	364.07198925	38.22134788	9.52535714839369	0.019338	1	0.104982940211185	0.019116	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0042470,melanosome;GO:0005634,nucleus	GO:0045296,cadherin binding;GO:0004601,peroxidase activity;GO:0003723,RNA binding;GO:0008379,thioredoxin peroxidase activity;GO:0016209,antioxidant activity;GO:0042802,identical protein binding;GO:0016491,oxidoreductase activity;GO:0051920,peroxiredoxin activity	GO:0008283,cell population proliferation;GO:0045454,cell redox homeostasis;GO:0034599,cellular response to oxidative stress;GO:0042744,hydrogen peroxide catabolic process;GO:0045321,leukocyte activation;GO:0030101,natural killer cell activation;GO:0019430,removal of superoxide radicals;GO:0001895,retina homeostasis;GO:0001501,skeletal system development;GO:0034101,erythrocyte homeostasis;GO:0042267,natural killer cell mediated cytotoxicity;GO:1901222,regulation of NIK/NF-kappaB signaling;GO:0032872,regulation of stress-activated MAPK cascade	hsa:5052,path:hsa04146,Peroxisome;hsa:5052,path:hsa05146,Amoebiasis
PP1R7_HUMAN	Q15435	PPP1R7	Protein phosphatase 1 regulatory subunit 7	1.730819076	1.447132664	2.489654438	2.365667892	1.58897587	2.427661165	1.58897587	2.427661165	0.654529508857551	0.365654	0	1.52781499759339	0.365888	0	GO:0005694,chromosome;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005634,nucleus;GO:0016021,integral component of membrane	GO:0030234,enzyme regulator activity;GO:0019888,protein phosphatase regulator activity	GO:0035307,positive regulation of protein dephosphorylation;GO:0061588,calcium activated phospholipid scrambling	
LV325_HUMAN	P01717	IGLV3-25	Immunoglobulin lambda variable 3-25	1.235401377	2.55E-05	0.64991905	0.646949577	0.6177134385	0.6484343135	0.6177134385	0.6484343135	0.952622996099357	0.449494	0	1.04973321460287	0.449332	0	GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0070062,extracellular exosome;GO:0072562,blood microparticle	GO:0003823,antigen binding	GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
GFPT1_HUMAN	Q06210	GFPT1	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	4.573131075	4.110110206	5.467719022	3.632067534	4.3416206405	4.549893278	4.3416206405	4.549893278	0.954224720279252	0.448934	0	1.04797117361134	0.448771	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0097367,carbohydrate derivative binding;GO:0004360,glutamine-fructose-6-phosphate transaminase (isomerizing) activity	GO:0032922,circadian regulation of gene expression;GO:0006112,energy reserve metabolic process;GO:0006002,fructose 6-phosphate metabolic process;GO:0006541,glutamine metabolic process;GO:0036498,IRE1-mediated unfolded protein response;GO:0006487,protein N-linked glycosylation;GO:0006048,UDP-N-acetylglucosamine biosynthetic process;GO:0006047,UDP-N-acetylglucosamine metabolic process;GO:1901135,carbohydrate derivative metabolic process	hsa:2673,path:hsa00520,Amino sugar and nucleotide sugar metabolism;hsa:2673,path:hsa00250,Alanine, aspartate and glutamate metabolism;hsa:2673,path:hsa04931,Insulin resistance
KAPCA_HUMAN	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	2.868717856	4.021380067	4.664079995	6.919041748	3.4450489615	5.7915608715	3.4450489615	5.7915608715	0.594839463477441	0.312236	0	1.68112585226606	0.312515	0	GO:0001669,acrosomal vesicle;GO:0034704,calcium channel complex;GO:0005952,cAMP-dependent protein kinase complex;GO:0005813,centrosome;GO:0097546,ciliary base;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0031594,neuromuscular junction;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0031588,nucleotide-activated protein kinase complex;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0044853,plasma membrane raft;GO:0036126,sperm flagellum;GO:0097225,sperm midpiece	GO:0004679,AMP-activated protein kinase activity;GO:0005524,ATP binding;GO:0004691,cAMP-dependent protein kinase activity;GO:0000287,magnesium ion binding;GO:0030145,manganese ion binding;GO:0019904,protein domain specific binding;GO:0034237,protein kinase A regulatory subunit binding;GO:0004672,protein kinase activity;GO:0019901,protein kinase binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0004712,protein serine/threonine/tyrosine kinase activity;GO:0106311,protein threonine kinase activity;GO:0031625,ubiquitin protein ligase binding	GO:0034199,activation of protein kinase A activity;GO:0002250,adaptive immune response;GO:0007596,blood coagulation;GO:0035584,calcium-mediated signaling using intracellular calcium source;GO:0086064,cell communication by electrical coupling involved in cardiac conduction;GO:0071872,cellular response to epinephrine stimulus;GO:0071377,cellular response to glucagon stimulus;GO:0071333,cellular response to glucose stimulus;GO:0034605,cellular response to heat;GO:0071374,cellular response to parathyroid hormone stimulus;GO:0007268,chemical synaptic transmission;GO:0097711,ciliary basal body-plasma membrane docking;GO:0019221,cytokine-mediated signaling pathway;GO:0000086,G2/M transition of mitotic cell cycle;GO:0034380,high-density lipoprotein particle assembly;GO:0001707,mesoderm formation;GO:0050804,modulation of chemical synaptic transmission;GO:0006397,mRNA processing;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:1901621,negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:0001843,neural tube closure;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:0071158,positive regulation of cell cycle arrest;GO:0046827,positive regulation of protein export from nucleus;GO:0046777,protein autophosphorylation;GO:0010737,protein kinase A signaling;GO:0006468,protein phosphorylation;GO:2000810,regulation of bicellular tight junction assembly;GO:1903779,regulation of cardiac conduction;GO:0055117,regulation of cardiac muscle contraction;GO:0010881,regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0051480,regulation of cytosolic calcium ion concentration;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0002027,regulation of heart rate;GO:0016241,regulation of macroautophagy;GO:0045667,regulation of osteoblast differentiation;GO:0061136,regulation of proteasomal protein catabolic process;GO:0043393,regulation of protein binding;GO:0070613,regulation of protein processing;GO:0060314,regulation of ryanodine-sensitive calcium-release channel activity;GO:0003091,renal water homeostasis;GO:0048240,sperm capacitation;GO:0002223,stimulatory C-type lectin receptor signaling pathway	hsa:5566,path:hsa04014,Ras signaling pathway;hsa:5566,path:hsa04010,MAPK signaling pathway;hsa:5566,path:hsa04310,Wnt signaling pathway;hsa:5566,path:hsa04340,Hedgehog signaling pathway;hsa:5566,path:hsa04371,Apelin signaling pathway;hsa:5566,path:hsa04020,Calcium signaling pathway;hsa:5566,path:hsa04024,cAMP signaling pathway;hsa:5566,path:hsa04140,Autophagy - animal;hsa:5566,path:hsa04114,Oocyte meiosis;hsa:5566,path:hsa04530,Tight junction;hsa:5566,path:hsa04540,Gap junction;hsa:5566,path:hsa04611,Platelet activation;hsa:5566,path:hsa04062,Chemokine signaling pathway;hsa:5566,path:hsa04911,Insulin secretion;hsa:5566,path:hsa04910,Insulin signaling pathway;hsa:5566,path:hsa04922,Glucagon signaling pathway;hsa:5566,path:hsa04923,Regulation of lipolysis in adipocytes;hsa:5566,path:hsa04912,GnRH signaling pathway;hsa:5566,path:hsa04913,Ovarian steroidogenesis;hsa:5566,path:hsa04915,Estrogen signaling pathway;hsa:5566,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:5566,path:hsa04921,Oxytocin signaling pathway;hsa:5566,path:hsa04926,Relaxin signaling pathway;hsa:5566,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:5566,path:hsa04918,Thyroid hormone synthesis;hsa:5566,path:hsa04919,Thyroid hormone signaling pathway;hsa:5566,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:5566,path:hsa04916,Melanogenesis;hsa:5566,path:hsa04924,Renin secretion;hsa:5566,path:hsa04925,Aldosterone synthesis and secretion;hsa:5566,path:hsa04927,Cortisol synthesis and secretion;hsa:5566,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:5566,path:hsa04270,Vascular smooth muscle contraction;hsa:5566,path:hsa04970,Salivary secretion;hsa:5566,path:hsa04971,Gastric acid secretion;hsa:5566,path:hsa04976,Bile secretion;hsa:5566,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:5566,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:5566,path:hsa04724,Glutamatergic synapse;hsa:5566,path:hsa04727,GABAergic synapse;hsa:5566,path:hsa04725,Cholinergic synapse;hsa:5566,path:hsa04728,Dopaminergic synapse;hsa:5566,path:hsa04726,Serotonergic synapse;hsa:5566,path:hsa04720,Long-term potentiation;hsa:5566,path:hsa04723,Retrograde endocannabinoid signaling;hsa:5566,path:hsa04740,Olfactory transduction;hsa:5566,path:hsa04742,Taste transduction;hsa:5566,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:5566,path:hsa04211,Longevity regulating pathway;hsa:5566,path:hsa04213,Longevity regulating pathway - multiple species;hsa:5566,path:hsa04713,Circadian entrainment;hsa:5566,path:hsa04714,Thermogenesis;hsa:5566,path:hsa05200,Pathways in cancer;hsa:5566,path:hsa05205,Proteoglycans in cancer;hsa:5566,path:hsa05203,Viral carcinogenesis;hsa:5566,path:hsa05012,Parkinson disease;hsa:5566,path:hsa05020,Prion diseases;hsa:5566,path:hsa05030,Cocaine addiction;hsa:5566,path:hsa05031,Amphetamine addiction;hsa:5566,path:hsa05032,Morphine addiction;hsa:5566,path:hsa05034,Alcoholism;hsa:5566,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:5566,path:hsa04934,Cushing syndrome;hsa:5566,path:hsa05110,Vibrio cholerae infection;hsa:5566,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:5566,path:hsa05163,Human cytomegalovirus infection;hsa:5566,path:hsa05165,Human papillomavirus infection;hsa:5566,path:hsa05146,Amoebiasis;hsa:5566,path:hsa01522,Endocrine resistance
CD47_HUMAN	Q08722	CD47	Leukocyte surface antigen CD47	1.458528777	1.933462814	2.437965621	6.602177689	1.6959957955	4.520071655	1.6959957955	4.520071655	0.375214360512168	0.116295	0	2.66514319610529	0.116608	0	GO:0009986,cell surface;GO:0070062,extracellular exosome;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane;GO:0035579,specific granule membrane;GO:0070821,tertiary granule membrane	GO:0098632,cell-cell adhesion mediator activity;GO:0086080,protein binding involved in heterotypic cell-cell adhesion;GO:0070053,thrombospondin receptor activity	GO:1904669,ATP export;GO:0016477,cell migration;GO:0071346,cellular response to interferon-gamma;GO:0071347,cellular response to interleukin-1;GO:0071349,cellular response to interleukin-12;GO:0030198,extracellular matrix organization;GO:0007229,integrin-mediated signaling pathway;GO:0050900,leukocyte migration;GO:0035696,monocyte extravasation;GO:1905450,negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0043312,neutrophil degranulation;GO:0008284,positive regulation of cell population proliferation;GO:0022409,positive regulation of cell-cell adhesion;GO:0050729,positive regulation of inflammatory response;GO:0050766,positive regulation of phagocytosis;GO:0051496,positive regulation of stress fiber assembly;GO:0050870,positive regulation of T cell activation;GO:0032649,regulation of interferon-gamma production;GO:0032653,regulation of interleukin-10 production;GO:0032655,regulation of interleukin-12 production;GO:0032675,regulation of interleukin-6 production;GO:0045428,regulation of nitric oxide biosynthetic process;GO:0032680,regulation of tumor necrosis factor production	hsa:961,path:hsa04512,ECM-receptor interaction
UB2V2_HUMAN	Q15819	UBE2V2	Ubiquitin-conjugating enzyme E2 variant 2	9.109795046	8.552145709	1.982035715	3.51103881	8.8309703775	2.7465372625	8.8309703775	2.7465372625	3.2153106014887	0.124609	0	0.311011943772087	0.124056	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0031372,UBC13-MMS2 complex		GO:0000729,DNA double-strand break processing;GO:0006302,double-strand break repair;GO:0006303,double-strand break repair via nonhomologous end joining;GO:0042275,error-free postreplication DNA repair;GO:0043524,negative regulation of neuron apoptotic process;GO:0045739,positive regulation of DNA repair;GO:0010976,positive regulation of neuron projection development;GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0051965,positive regulation of synapse assembly;GO:0006301,postreplication repair;GO:0070534,protein K63-linked ubiquitination;GO:0000209,protein polyubiquitination;GO:0016567,protein ubiquitination;GO:0006282,regulation of DNA repair	hsa:7336,path:hsa05131,Shigellosis
ACSL5_HUMAN	Q9ULC5	ACSL5	Long-chain-fatty-acid--CoA ligase 5	0.289972649	0.328947546	1.040034025	0.591950382	0.3094600975	0.8159922035	0.3094600975	0.8159922035	0.379243939062955	0.119520	0	2.63682526468538	0.119835	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0047676,arachidonate-CoA ligase activity;GO:0005524,ATP binding;GO:0004467,long-chain fatty acid-CoA ligase activity	GO:0008610,lipid biosynthetic process;GO:0001676,long-chain fatty acid metabolic process;GO:0035338,long-chain fatty-acyl-CoA biosynthetic process;GO:0010747,positive regulation of long-chain fatty acid import across plasma membrane;GO:2001236,regulation of extrinsic apoptotic signaling pathway	hsa:51703,path:hsa00061,Fatty acid biosynthesis;hsa:51703,path:hsa00071,Fatty acid degradation;hsa:51703,path:hsa04146,Peroxisome;hsa:51703,path:hsa04216,Ferroptosis;hsa:51703,path:hsa04920,Adipocytokine signaling pathway;hsa:51703,path:hsa03320,PPAR signaling pathway;hsa:51703,path:hsa04714,Thermogenesis
CATE_HUMAN	P14091	CTSE	Cathepsin E	0.144199108	0.979758322	1.158299947	0.277500218	0.561978715	0.7179000825	0.561978715	0.7179000825	0.782809096556971	0.472145	0	1.27745066376758	0.472268	0	GO:0005768,endosome	GO:0004190,aspartic-type endopeptidase activity;GO:0042802,identical protein binding;GO:0008233,peptidase activity	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0016540,protein autoprocessing;GO:0006508,proteolysis	hsa:1510,path:hsa04142,Lysosome
LRC8A_HUMAN	Q8IWT6	LRRC8A	Volume-regulated anion channel subunit LRRC8A	0.017940438	0.011831537	0.031216859	2.55E-05	0.0148859875	0.0156211795	0.0148859875	0.0156211795	0.952936204337195	0.449385	0	1.04938819141155	0.449222	0	GO:0009986,cell surface;GO:1905103,integral component of lysosomal membrane;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0034702,ion channel complex;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0140360,cyclic-GMP-AMP transmembrane transporter activity;GO:0042802,identical protein binding;GO:0005225,volume-sensitive anion channel activity	GO:0098656,anion transmembrane transport;GO:0006820,anion transport;GO:0015810,aspartate transmembrane transport;GO:0006884,cell volume homeostasis;GO:0001678,cellular glucose homeostasis;GO:1902476,chloride transmembrane transport;GO:0140361,cyclic-GMP-AMP transmembrane import across plasma membrane;GO:0032024,positive regulation of insulin secretion;GO:0045663,positive regulation of myoblast differentiation;GO:0002329,pre-B cell differentiation;GO:0034214,protein hexamerization;GO:0006970,response to osmotic stress;GO:0007283,spermatogenesis;GO:0015734,taurine transport;GO:0055085,transmembrane transport	
UBA6_HUMAN	A0AVT1	UBA6	Ubiquitin-like modifier-activating enzyme 6	1.05432359	0.775382837	1.662746493	1.119290412	0.9148532135	1.3910184525	0.9148532135	1.3910184525	0.657685893278975	0.368422	0	1.52048266538663	0.368654	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0019780,FAT10 activating enzyme activity;GO:0004839,ubiquitin activating enzyme activity;GO:0008641,ubiquitin-like modifier activating enzyme activity	GO:0021764,amygdala development;GO:0006974,cellular response to DNA damage stimulus;GO:0060996,dendritic spine development;GO:0021766,hippocampus development;GO:0007612,learning;GO:0007626,locomotory behavior;GO:0032446,protein modification by small protein conjugation;GO:0016567,protein ubiquitination;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:55236,path:hsa04120,Ubiquitin mediated proteolysis
PICAL_HUMAN	Q13492	PICALM	Phosphatidylinositol-binding clathrin assembly protein	2.463217434	7.001313584	5.277981943	8.089482714	4.732265509	6.6837323285	4.732265509	6.6837323285	0.708027382967032	0.411643	0	1.41237475280891	0.411831	0	GO:0009986,cell surface;GO:0045334,clathrin-coated endocytic vesicle;GO:0005905,clathrin-coated pit;GO:0030136,clathrin-coated vesicle;GO:0005829,cytosol;GO:0005769,early endosome;GO:0070381,endosome to plasma membrane transport vesicle;GO:0098894,extrinsic component of presynaptic endocytic zone membrane;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0031224,intrinsic component of membrane;GO:0016020,membrane;GO:0097418,neurofibrillary tangle;GO:0043025,neuronal cell body;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0045211,postsynaptic membrane;GO:0042734,presynaptic membrane;GO:0008021,synaptic vesicle;GO:0031982,vesicle	GO:0005545,1-phosphatidylinositol binding;GO:0001540,amyloid-beta binding;GO:0045296,cadherin binding;GO:0030276,clathrin binding;GO:0032050,clathrin heavy chain binding;GO:0050750,low-density lipoprotein particle receptor binding;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding;GO:0031267,small GTPase binding;GO:0000149,SNARE binding;GO:0048156,tau protein binding;GO:0005543,phospholipid binding	GO:0150093,amyloid-beta clearance by transcytosis;GO:0007409,axonogenesis;GO:0048268,clathrin coat assembly;GO:1905224,clathrin-coated pit assembly;GO:0072583,clathrin-dependent endocytosis;GO:0048813,dendrite morphogenesis;GO:0006897,endocytosis;GO:0016197,endosomal transport;GO:0030097,hemopoiesis;GO:0055072,iron ion homeostasis;GO:0007611,learning or memory;GO:0097753,membrane bending;GO:0061024,membrane organization;GO:0090647,modulation of age-related behavioral decline;GO:0010629,negative regulation of gene expression;GO:1902963,negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process;GO:2000009,negative regulation of protein localization to cell surface;GO:1903077,negative regulation of protein localization to plasma membrane;GO:0048261,negative regulation of receptor-mediated endocytosis;GO:1902004,positive regulation of amyloid-beta formation;GO:1902961,positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:0043547,positive regulation of GTPase activity;GO:1901216,positive regulation of neuron death;GO:0045893,positive regulation of transcription, DNA-templated;GO:0065003,protein-containing complex assembly;GO:0031623,receptor internalization;GO:0006898,receptor-mediated endocytosis;GO:1902959,regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:0030100,regulation of endocytosis;GO:0032880,regulation of protein localization;GO:0097494,regulation of vesicle size;GO:0016185,synaptic vesicle budding from presynaptic endocytic zone membrane;GO:0016188,synaptic vesicle maturation;GO:0006900,vesicle budding from membrane;GO:0035459,vesicle cargo loading;GO:0016192,vesicle-mediated transport	
TRM11_HUMAN	Q7Z4G4	TRMT11	tRNA (guanine(10)-N2)-methyltransferase homolog	0.018221803	2.55E-05	0.036976669	2.55E-05	0.0091236515	0.0185010845	0.0091236515	0.0185010845	0.493141442600297	0.218858	0	2.02781578187198	0.219188	0	GO:0005737,cytoplasm	GO:0008168,methyltransferase activity;GO:0004809,tRNA (guanine-N2-)-methyltransferase activity;GO:0000049,tRNA binding		
ODPB_HUMAN	P11177	PDHB	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	4.007357436	3.141612338	4.347254016	3.551139478	3.574484887	3.949196747	3.574484887	3.949196747	0.905116943012614	0.466599	0	1.10482961093577	0.466474	0	GO:0005759,mitochondrial matrix;GO:0005967,mitochondrial pyruvate dehydrogenase complex;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0045254,pyruvate dehydrogenase complex	GO:0004739,pyruvate dehydrogenase (acetyl-transferring) activity	GO:0006086,acetyl-CoA biosynthetic process from pyruvate;GO:0006006,glucose metabolic process;GO:0061732,mitochondrial acetyl-CoA biosynthetic process from pyruvate;GO:0006090,pyruvate metabolic process;GO:0006099,tricarboxylic acid cycle	hsa:5162,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:5162,path:hsa00020,Citrate cycle (TCA cycle);hsa:5162,path:hsa00620,Pyruvate metabolism;hsa:5162,path:hsa04066,HIF-1 signaling pathway;hsa:5162,path:hsa04922,Glucagon signaling pathway;hsa:5162,path:hsa05230,Central carbon metabolism in cancer
SMCA2_HUMAN	P51531	SMARCA2	Probable global transcription activator SNF2L2	0.24118305	0.176095716	0.246004232	0.237851507	0.208639383	0.2419278695	0.208639383	0.2419278695	0.862403258587783	0.482820	0	1.15955034960969	0.482731	0	GO:0000785,chromatin;GO:0045111,intermediate filament cytoskeleton;GO:0043231,intracellular membrane-bounded organelle;GO:0071565,nBAF complex;GO:0071564,npBAF complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016514,SWI/SNF complex	GO:0005524,ATP binding;GO:0008094,ATPase activity, acting on DNA;GO:0003682,chromatin binding;GO:0003677,DNA binding;GO:0004386,helicase activity;GO:0042393,histone binding;GO:0070615,nucleosome-dependent ATPase activity;GO:0003713,transcription coactivator activity;GO:0000976,transcription regulatory region sequence-specific DNA binding;GO:0016887,ATPase activity;GO:0016787,hydrolase activity	GO:0043044,ATP-dependent chromatin remodeling;GO:0006338,chromatin remodeling;GO:0030308,negative regulation of cell growth;GO:0008285,negative regulation of cell population proliferation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0007399,nervous system development;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0006357,regulation of transcription by RNA polymerase II;GO:0006355,regulation of transcription, DNA-templated;GO:0007286,spermatid development	hsa:6595,path:hsa04714,Thermogenesis;hsa:6595,path:hsa05225,Hepatocellular carcinoma
AP2B1_HUMAN	P63010	AP2B1	AP-2 complex subunit beta	1.505283392	2.703679552	3.031511577	3.572731782	2.104481472	3.3021216795	2.104481472	3.3021216795	0.63731190920822	0.350443	0	1.56909040228414	0.350691	0	GO:0030122,AP-2 adaptor complex;GO:0030131,clathrin adaptor complex;GO:0045334,clathrin-coated endocytic vesicle;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0005829,cytosol;GO:0030666,endocytic vesicle membrane;GO:0036020,endolysosome membrane;GO:0098978,glutamatergic synapse;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0098794,postsynapse;GO:0098793,presynapse;GO:0030117,membrane coat	GO:0030276,clathrin binding;GO:0044877,protein-containing complex binding;GO:0005048,signal sequence binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0035904,aorta development;GO:0048268,clathrin coat assembly;GO:0072583,clathrin-dependent endocytosis;GO:0060976,coronary vasculature development;GO:0048013,ephrin receptor signaling pathway;GO:0006886,intracellular protein transport;GO:0001822,kidney development;GO:0034383,low-density lipoprotein particle clearance;GO:0032802,low-density lipoprotein particle receptor catabolic process;GO:0061024,membrane organization;GO:1901215,negative regulation of neuron death;GO:0045807,positive regulation of endocytosis;GO:1905477,positive regulation of protein localization to membrane;GO:0098884,postsynaptic neurotransmitter receptor internalization;GO:0050690,regulation of defense response to virus by virus;GO:0048488,synaptic vesicle endocytosis;GO:0003281,ventricular septum development;GO:0016192,vesicle-mediated transport;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:163,path:hsa04144,Endocytosis;hsa:163,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:163,path:hsa04721,Synaptic vesicle cycle;hsa:163,path:hsa05016,Huntington disease
SE1L1_HUMAN	Q9UBV2	SEL1L	Protein sel-1 homolog 1	0.192240262	0.270054409	0.435463853	0.161942034	0.2311473355	0.2987029435	0.2311473355	0.2987029435	0.77383681858495	0.465139	0	1.29226211002549	0.465269	0	GO:0036513,Derlin-1 retrotranslocation complex;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0044322,endoplasmic reticulum quality control compartment;GO:0000836,Hrd1p ubiquitin ligase complex;GO:0000839,Hrd1p ubiquitin ligase ERAD-L complex;GO:0016021,integral component of membrane		GO:1904380,endoplasmic reticulum mannose trimming;GO:0036503,ERAD pathway;GO:0007219,Notch signaling pathway;GO:0009306,protein secretion;GO:0050821,protein stabilization;GO:0016567,protein ubiquitination;GO:0030970,retrograde protein transport, ER to cytosol;GO:0055085,transmembrane transport;GO:0006641,triglyceride metabolic process;GO:0030433,ubiquitin-dependent ERAD pathway	hsa:6400,path:hsa04141,Protein processing in endoplasmic reticulum
STOM_HUMAN	P27105	STOM	Stomatin	2.334064045	4.672074487	4.181264994	18.98050581	3.503069266	11.580885402	3.503069266	11.580885402	0.302487171265422	0.063882	0	3.30592532508605	0.064129	0	GO:0035577,azurophil granule membrane;GO:0072562,blood microparticle;GO:0005856,cytoskeleton;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005887,integral component of plasma membrane;GO:0042470,melanosome;GO:0016020,membrane;GO:0045121,membrane raft;GO:0005739,mitochondrion;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0035579,specific granule membrane;GO:0070821,tertiary granule membrane;GO:0031982,vesicle	GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:0070063,RNA polymerase binding	GO:0043312,neutrophil degranulation;GO:0044829,positive regulation by host of viral genome replication;GO:0090314,positive regulation of protein targeting to membrane;GO:0048524,positive regulation of viral process;GO:1901585,regulation of acid-sensing ion channel activity	
NCEH1_HUMAN	Q6PIU2	NCEH1	Neutral cholesterol ester hydrolase 1	1.939246929	5.056759034	3.326559757	2.720734602	3.4980029815	3.0236471795	3.4980029815	3.0236471795	1.15688199510051	0.385649	0	0.864392396316201	0.385353	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0052689,carboxylic ester hydrolase activity;GO:0016787,hydrolase activity;GO:0042301,phosphate ion binding;GO:0017171,serine hydrolase activity	GO:0046485,ether lipid metabolic process;GO:0016042,lipid catabolic process;GO:0034383,low-density lipoprotein particle clearance;GO:0006470,protein dephosphorylation;GO:0060395,SMAD protein signal transduction;GO:0006805,xenobiotic metabolic process	hsa:57552,path:hsa04927,Cortisol synthesis and secretion;hsa:57552,path:hsa04976,Bile secretion;hsa:57552,path:hsa04979,Cholesterol metabolism;hsa:57552,path:hsa04934,Cushing syndrome
SYYC_HUMAN	P54577	YARS1	Tyrosine--tRNA ligase, cytoplasmic	4.65399372	3.47507431	5.687565609	3.92125365	4.064534015	4.8044096295	4.064534015	4.8044096295	0.846000721929075	0.489273	0	1.18203208824665	0.489199	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005615,extracellular space;GO:0016604,nuclear body	GO:0005524,ATP binding;GO:0005153,interleukin-8 receptor binding;GO:0003723,RNA binding;GO:0000049,tRNA binding;GO:0004831,tyrosine-tRNA ligase activity;GO:0004812,aminoacyl-tRNA ligase activity	GO:0006915,apoptotic process;GO:0006418,tRNA aminoacylation for protein translation;GO:0006437,tyrosyl-tRNA aminoacylation	hsa:8565,path:hsa00970,Aminoacyl-tRNA biosynthesis
SNX3_HUMAN	O60493	SNX3	Sorting nexin-3	1.812259055	9.180341644	0.294715793	0.172755672	5.4963003495	0.2337357325	5.4963003495	0.2337357325	23.5150196793295	0.002332	1	0.0425260116145696	0.002286	-1	GO:0030136,clathrin-coated vesicle;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0032009,early phagosome;GO:0010008,endosome membrane;GO:0070062,extracellular exosome	GO:0080025,phosphatidylinositol-3,5-bisphosphate binding;GO:0032266,phosphatidylinositol-3-phosphate binding;GO:0070273,phosphatidylinositol-4-phosphate binding;GO:0010314,phosphatidylinositol-5-phosphate binding;GO:0019903,protein phosphatase binding;GO:1905394,retromer complex binding	GO:0032456,endocytic recycling;GO:0070676,intralumenal vesicle formation;GO:0034499,late endosome to Golgi transport;GO:0010324,membrane invagination;GO:2000642,negative regulation of early endosome to late endosome transport;GO:0050765,negative regulation of phagocytosis;GO:0042177,negative regulation of protein catabolic process;GO:0051224,negative regulation of protein transport;GO:0046597,negative regulation of viral entry into host cell;GO:0010976,positive regulation of neuron projection development;GO:0016579,protein deubiquitination;GO:0022615,protein to membrane docking;GO:0015031,protein transport;GO:0030111,regulation of Wnt signaling pathway;GO:0009617,response to bacterium;GO:0016055,Wnt signaling pathway	hsa:8724,path:hsa04144,Endocytosis
SPTC1_HUMAN	O15269	SPTLC1	Serine palmitoyltransferase 1	0.152677929	0.101209852	0.317724904	0.55627084	0.1269438905	0.436997872	0.1269438905	0.436997872	0.2904908665093	0.056503	0	3.44244902435852	0.056736	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0017059,serine C-palmitoyltransferase complex;GO:0035339,SPOTS complex	GO:0030170,pyridoxal phosphate binding;GO:0004758,serine C-palmitoyltransferase activity;GO:0003824,catalytic activity	GO:0046513,ceramide biosynthetic process;GO:1904504,positive regulation of lipophagy;GO:1904649,regulation of fat cell apoptotic process;GO:0030148,sphingolipid biosynthetic process;GO:0006665,sphingolipid metabolic process;GO:0046512,sphingosine biosynthetic process	hsa:10558,path:hsa00600,Sphingolipid metabolism;hsa:10558,path:hsa04071,Sphingolipid signaling pathway
ERP44_HUMAN	Q9BS26	ERP44	Endoplasmic reticulum resident protein 44	4.764494883	4.944944665	5.983423522	3.984433155	4.854719774	4.9839283385	4.854719774	4.9839283385	0.974074955391737	0.442076	0	1.02661504072634	0.441897	0	GO:0009986,cell surface;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0035580,specific granule lumen	GO:0003756,protein disulfide isomerase activity	GO:0045454,cell redox homeostasis;GO:0009100,glycoprotein metabolic process;GO:0043312,neutrophil degranulation;GO:0006457,protein folding;GO:0034976,response to endoplasmic reticulum stress;GO:0006986,response to unfolded protein	
DHX16_HUMAN	O60231	DHX16	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16	0.422711555	0.435722067	0.525963315	0.764633928	0.429216811	0.6452986215	0.429216811	0.6452986215	0.665144472186045	0.374939	0	1.50343277560953	0.375164	0	GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0071005,U2-type precatalytic spliceosome	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0016787,hydrolase activity;GO:0004386,helicase activity;GO:0003676,nucleic acid binding	GO:0000398,mRNA splicing, via spliceosome;GO:0008380,RNA splicing	hsa:8449,path:hsa03040,Spliceosome
TBC9B_HUMAN	Q66K14	TBC1D9B	TBC1 domain family member 9B	0.499915031	0.611723759	0.536314865	0.399927686	0.555819395	0.4681212755	0.555819395	0.4681212755	1.18734059759691	0.377299	0	0.842218317156781	0.376986	0	GO:0016021,integral component of membrane	GO:0005509,calcium ion binding;GO:0005096,GTPase activator activity	GO:0090630,activation of GTPase activity;GO:0006886,intracellular protein transport	
EOGT_HUMAN	Q5NDL2	EOGT	EGF domain-specific O-linked N-acetylglucosamine transferase	0.260224664	0.458919147	0.308623109	0.471584934	0.3595719055	0.3901040215	0.3595719055	0.3901040215	0.921733398485358	0.460507	0	1.0849124070401	0.460369	0	GO:0005788,endoplasmic reticulum lumen;GO:0016021,integral component of membrane	GO:0016262,protein N-acetylglucosaminyltransferase activity;GO:0097363,protein O-GlcNAc transferase activity;GO:0016757,transferase activity, transferring glycosyl groups	GO:0097370,protein O-GlcNAcylation via threonine;GO:0006493,protein O-linked glycosylation	hsa:285203,path:hsa00514,Other types of O-glycan biosynthesis
SAHH_HUMAN	P23526	AHCY	Adenosylhomocysteinase	9.915272516	10.67108452	14.27404091	15.33237167	10.293178518	14.80320629	10.293178518	14.80320629	0.695334396910576	0.400920	0	1.43815695648464	0.401120	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0042470,melanosome;GO:0043005,neuron projection;GO:0005634,nucleus	GO:0004013,adenosylhomocysteinase activity;GO:0030554,adenyl nucleotide binding;GO:0042802,identical protein binding;GO:0051287,NAD binding	GO:0002439,chronic inflammatory response to antigenic stimulus;GO:0042745,circadian sleep/wake cycle;GO:0032259,methylation;GO:0006730,one-carbon metabolic process;GO:0001666,response to hypoxia;GO:0007584,response to nutrient;GO:0019510,S-adenosylhomocysteine catabolic process;GO:0033353,S-adenosylmethionine cycle;GO:0000096,sulfur amino acid metabolic process	hsa:191,path:hsa00270,Cysteine and methionine metabolism
ALDR_HUMAN	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	6.544791273	27.29769562	9.081086331	11.74821185	16.9212434465	10.4146490905	16.9212434465	10.4146490905	1.62475406511153	0.281991	0	0.615477764587931	0.281513	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0042629,mast cell granule;GO:0005654,nucleoplasm;GO:0033010,paranodal junction;GO:0048471,perinuclear region of cytoplasm;GO:0032838,plasma membrane bounded cell projection cytoplasm;GO:0043220,Schmidt-Lanterman incisure;GO:0097454,Schwann cell microvillus	GO:0004032,alditol;GO:0047655,allyl-alcohol dehydrogenase activity;GO:0047834,D-threo-aldose 1-dehydrogenase activity;GO:0009055,electron transfer activity;GO:0043795,glyceraldehyde oxidoreductase activity;GO:0047956,glycerol dehydrogenase [NADP+] activity;GO:0052650,NADP-retinol dehydrogenase activity;GO:0036130,prostaglandin H2 endoperoxidase reductase activity;GO:0001758,retinal dehydrogenase activity	GO:0006700,C21-steroid hormone biosynthetic process;GO:0005975,carbohydrate metabolic process;GO:0071475,cellular hyperosmotic salinity response;GO:0097238,cellular response to methylglyoxal;GO:1901653,cellular response to peptide;GO:0044597,daunorubicin metabolic process;GO:0044598,doxorubicin metabolic process;GO:0002070,epithelial cell maturation;GO:0046370,fructose biosynthetic process;GO:0072061,inner medullary collecting duct development;GO:0060135,maternal process involved in female pregnancy;GO:0072205,metanephric collecting duct development;GO:0018931,naphthalene metabolic process;GO:0043066,negative regulation of apoptotic process;GO:0042415,norepinephrine metabolic process;GO:0046427,positive regulation of receptor signaling pathway via JAK-STAT;GO:0048661,positive regulation of smooth muscle cell proliferation;GO:0035809,regulation of urine volume;GO:0003091,renal water homeostasis;GO:0097066,response to thyroid hormone;GO:0009414,response to water deprivation;GO:0001523,retinoid metabolic process;GO:0006061,sorbitol biosynthetic process;GO:0031098,stress-activated protein kinase signaling cascade;GO:0001894,tissue homeostasis	hsa:231,path:hsa00040,Pentose and glucuronate interconversions;hsa:231,path:hsa00051,Fructose and mannose metabolism;hsa:231,path:hsa00052,Galactose metabolism;hsa:231,path:hsa00561,Glycerolipid metabolism;hsa:231,path:hsa00790,Folate biosynthesis
AASS_HUMAN	Q9UDR5	AASS	Alpha-aminoadipic semialdehyde synthase, mitochondrial	0.373161092	0.18486163	1.951732532	0.358268272	0.279011361	1.155000402	0.279011361	1.155000402	0.241568193843797	0.030975	-1	4.13961782007866	0.031141	1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0042393,histone binding;GO:0047131,saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity;GO:0004754,saccharopine dehydrogenase (NAD+, L-lysine-forming) activity;GO:0047130,saccharopine dehydrogenase (NADP+, L-lysine-forming) activity;GO:0004753,saccharopine dehydrogenase activity;GO:0003714,transcription corepressor activity	GO:0033512,L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0019878,lysine biosynthetic process via aminoadipic acid;GO:0006554,lysine catabolic process;GO:0031061,negative regulation of histone methylation;GO:0000122,negative regulation of transcription by RNA polymerase II	hsa:10157,path:hsa00310,Lysine degradation
NCLN_HUMAN	Q969V3	NCLN	Nicalin	3.463405172	2.051456572	3.123816759	1.987307063	2.757430872	2.555561911	2.757430872	2.555561911	1.07899200568419	0.408297	0	0.926790925912285	0.408047	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0032991,protein-containing complex	GO:0008235,metalloexopeptidase activity;GO:0043022,ribosome binding	GO:0050821,protein stabilization;GO:0061635,regulation of protein complex stability;GO:0043254,regulation of protein-containing complex assembly;GO:0009966,regulation of signal transduction	
CYFP1_HUMAN	Q7L576	CYFIP1	Cytoplasmic FMR1-interacting protein 1	5.018575021	7.416485031	6.868503135	10.09572013	6.217530026	8.4821116325	6.217530026	8.4821116325	0.733016764619904	0.432382	0	1.36422527869269	0.432548	0	GO:0044295,axonal growth cone;GO:0090724,central region of growth cone;GO:0005829,cytosol;GO:0044294,dendritic growth cone;GO:0043197,dendritic spine;GO:0060076,excitatory synapse;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0032433,filopodium tip;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0005845,mRNA cap binding complex;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0048471,perinuclear region of cytoplasm;GO:0090725,peripheral region of growth cone;GO:0001726,ruffle;GO:0031209,SCAR complex;GO:0034774,secretory granule lumen;GO:0035580,specific granule lumen;GO:0045202,synapse;GO:0043195,terminal bouton;GO:1904724,tertiary granule lumen	GO:0051015,actin filament binding;GO:0000340,RNA 7-methylguanosine cap binding;GO:0031267,small GTPase binding;GO:0045182,translation regulator activity	GO:0048675,axon extension;GO:0007411,axon guidance;GO:0000902,cell morphogenesis;GO:0030031,cell projection assembly;GO:0032869,cellular response to insulin stimulus;GO:0050890,cognition;GO:0097484,dendrite extension;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0030032,lamellipodium assembly;GO:0099563,modification of synaptic structure;GO:1903422,negative regulation of synaptic vesicle recycling;GO:0043312,neutrophil degranulation;GO:2000601,positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0045773,positive regulation of axon extension;GO:1900006,positive regulation of dendrite development;GO:0010592,positive regulation of lamellipodium assembly;GO:0051388,positive regulation of neurotrophin TRK receptor signaling pathway;GO:1900029,positive regulation of ruffle assembly;GO:0016601,Rac protein signal transduction;GO:0008360,regulation of cell shape;GO:1905274,regulation of modification of postsynaptic actin cytoskeleton;GO:0031641,regulation of myelination;GO:0006417,regulation of translation;GO:0099578,regulation of translation at postsynapse, modulating synaptic transmission;GO:0051602,response to electrical stimulus;GO:0031529,ruffle organization;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:0030833,regulation of actin filament polymerization	hsa:23191,path:hsa03013,RNA transport;hsa:23191,path:hsa04810,Regulation of actin cytoskeleton;hsa:23191,path:hsa05130,Pathogenic Escherichia coli infection;hsa:23191,path:hsa05132,Salmonella infection
TM214_HUMAN	Q6NUQ4	TMEM214	Transmembrane protein 214	1.13156411	0.505892887	0.961775671	0.679183587	0.8187284985	0.820479629	0.8187284985	0.820479629	0.997865723367033	0.434060	0	1.00213884151243	0.433864	0	GO:0005881,cytoplasmic microtubule;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane		GO:0006915,apoptotic process	
VINEX_HUMAN	O60504	SORBS3	Vinexin	0.261862134	0.368726887	0.42331348	1.078132622	0.3152945105	0.750723051	0.3152945105	0.750723051	0.419987783883833	0.153522	0	2.38102163532593	0.153854	0	GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005634,nucleus	GO:0005200,structural constituent of cytoskeleton;GO:0008134,transcription factor binding;GO:0017166,vinculin binding	GO:0007015,actin filament organization;GO:0007155,cell adhesion;GO:0031589,cell-substrate adhesion;GO:0006936,muscle contraction;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0051495,positive regulation of cytoskeleton organization;GO:0043410,positive regulation of MAPK cascade;GO:0051496,positive regulation of stress fiber assembly	
PNPH_HUMAN	P00491	PNP	Purine nucleoside phosphorylase	5.883610192	7.523709156	7.104120102	7.648708906	6.703659674	7.376414504	6.703659674	7.376414504	0.908796498673551	0.465240	0	1.10035635201012	0.465112	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005634,nucleus;GO:0034774,secretory granule lumen	GO:0047975,guanosine phosphorylase activity;GO:0042802,identical protein binding;GO:0001882,nucleoside binding;GO:0042301,phosphate ion binding;GO:0002060,purine nucleobase binding;GO:0004731,purine-nucleoside phosphorylase activity	GO:0046059,dAMP catabolic process;GO:0006955,immune response;GO:0006204,IMP catabolic process;GO:0006148,inosine catabolic process;GO:0043312,neutrophil degranulation;GO:0006738,nicotinamide riboside catabolic process;GO:0006139,nucleobase-containing compound metabolic process;GO:0009165,nucleotide biosynthetic process;GO:0046638,positive regulation of alpha-beta T cell differentiation;GO:0032743,positive regulation of interleukin-2 production;GO:0042102,positive regulation of T cell proliferation;GO:0006195,purine nucleotide catabolic process;GO:0006166,purine ribonucleoside salvage;GO:0043101,purine-containing compound salvage;GO:0042493,response to drug;GO:0034418,urate biosynthetic process;GO:0009116,nucleoside metabolic process	hsa:4860,path:hsa00230,Purine metabolism;hsa:4860,path:hsa00240,Pyrimidine metabolism;hsa:4860,path:hsa00760,Nicotinate and nicotinamide metabolism
TRIM2_HUMAN	Q9C040	TRIM2	Tripartite motif-containing protein 2	0.140479772	0.044168959	0.113966996	0.318142256	0.0923243655	0.216054626	0.0923243655	0.216054626	0.427319549732761	0.159870	0	2.34016908570035	0.160203	0	GO:0005737,cytoplasm	GO:0061630,ubiquitin protein ligase activity;GO:0004842,ubiquitin-protein transferase activity;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209,protein polyubiquitination;GO:0043523,regulation of neuron apoptotic process	
MIC27_HUMAN	Q6UXV4	APOOL	MICOS complex subunit MIC27	0.173753113	0.197126721	0.118750918	0.045597087	0.185439917	0.0821740025	0.185439917	0.0821740025	2.25667378195434	0.196595	0	0.443130065141261	0.196032	0	GO:0005576,extracellular region;GO:0140275,MIB complex;GO:0061617,MICOS complex;GO:0005739,mitochondrion;GO:0031093,platelet alpha granule lumen;GO:0001401,SAM complex		GO:0042407,cristae formation;GO:0007007,inner mitochondrial membrane organization;GO:0002576,platelet degranulation	
SCRIB_HUMAN	Q14160	SCRIB	Protein scribble homolog	0.12979136	0.111940683	0.142151099	0.177498245	0.1208660215	0.159824672	0.1208660215	0.159824672	0.75624132361742	0.451194	0	1.32232922054111	0.451340	0	GO:0005912,adherens junction;GO:0016323,basolateral plasma membrane;GO:0030054,cell junction;GO:0005911,cell-cell junction;GO:0070062,extracellular exosome;GO:0001772,immunological synapse;GO:0030027,lamellipodium;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0098793,presynapse;GO:0034750,Scrib-APC-beta-catenin complex;GO:0044291,cell-cell contact zone;GO:0005737,cytoplasm;GO:0099147,extrinsic component of postsynaptic density membrane;GO:0098978,glutamatergic synapse;GO:0035748,myelin sheath abaxonal region	GO:0045296,cadherin binding	GO:0090630,activation of GTPase activity;GO:0060561,apoptotic process involved in morphogenesis;GO:0016477,cell migration;GO:0008283,cell population proliferation;GO:0098609,cell-cell adhesion;GO:0035089,establishment of apical/basal cell polarity;GO:0001768,establishment of T cell polarity;GO:0045197,establishment or maintenance of epithelial cell apical/basal polarity;GO:0060603,mammary gland duct morphogenesis;GO:0030683,mitigation of host immune response by virus;GO:0046007,negative regulation of activated T cell proliferation;GO:0045930,negative regulation of mitotic cell cycle;GO:0001843,neural tube closure;GO:0098968,neurotransmitter receptor transport postsynaptic membrane to endosome;GO:0098887,neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0030859,polarized epithelial cell differentiation;GO:0050918,positive chemotaxis;GO:0043065,positive regulation of apoptotic process;GO:0032729,positive regulation of interferon-gamma production;GO:0001921,positive regulation of receptor recycling;GO:0071896,protein localization to adherens junction;GO:0043113,receptor clustering;GO:0097120,receptor localization to synapse;GO:0039563,suppression by virus of host STAT1 activity;GO:0039564,suppression by virus of host STAT2 activity;GO:0043615,astrocyte cell migration;GO:0060088,auditory receptor cell stereocilium organization;GO:0021747,cochlear nucleus development;GO:0036342,post-anal tail morphogenesis;GO:0099149,regulation of postsynaptic neurotransmitter receptor internalization;GO:0048488,synaptic vesicle endocytosis;GO:0016080,synaptic vesicle targeting;GO:0042060,wound healing	hsa:23513,path:hsa04390,Hippo signaling pathway;hsa:23513,path:hsa04530,Tight junction;hsa:23513,path:hsa05203,Viral carcinogenesis;hsa:23513,path:hsa05165,Human papillomavirus infection
COL12_HUMAN	Q5KU26	COLEC12	Collectin-12	0.139996993	0.4935393	0.277234011	0.21330314	0.3167681465	0.2452685755	0.3167681465	0.2452685755	1.29151541673956	0.350687	0	0.774284214527233	0.350323	0	GO:0005581,collagen trimer;GO:0030666,endocytic vesicle membrane;GO:0031012,extracellular matrix;GO:0005615,extracellular space;GO:0016021,integral component of membrane;GO:0005886,plasma membrane	GO:0005534,galactose binding;GO:0030169,low-density lipoprotein particle binding;GO:0046872,metal ion binding;GO:0038187,pattern recognition receptor activity;GO:0005044,scavenger receptor activity	GO:0009756,carbohydrate mediated signaling;GO:0071360,cellular response to exogenous dsRNA;GO:0006952,defense response;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006910,phagocytosis, recognition;GO:0060355,positive regulation of cell adhesion molecule production;GO:0006898,receptor-mediated endocytosis;GO:0050776,regulation of immune response;GO:0034138,toll-like receptor 3 signaling pathway	hsa:81035,path:hsa04145,Phagosome
CCD22_HUMAN	O60826	CCDC22	Coiled-coil domain-containing protein 22	1.29082093	0.284028147	0.288353503	0.155236311	0.7874245385	0.221794907	0.7874245385	0.221794907	3.55023724011841	0.108272	0	0.281671317257279	0.107737	0	GO:0005829,cytosol;GO:0005768,endosome;GO:0005654,nucleoplasm	GO:0097602,cullin family protein binding	GO:0006878,cellular copper ion homeostasis;GO:0007253,cytoplasmic sequestering of NF-kappaB;GO:0032456,endocytic recycling;GO:0006893,Golgi to plasma membrane transport;GO:0043124,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:2000060,positive regulation of ubiquitin-dependent protein catabolic process;GO:0043687,post-translational protein modification;GO:0015031,protein transport;GO:0016567,protein ubiquitination	
PCNA_HUMAN	P12004	PCNA	Proliferating cell nuclear antigen	1.433313286	0.934123893	1.747888092	4.354726914	1.1837185895	3.051307503	1.1837185895	3.051307503	0.387938150558797	0.126571	0	2.57773049275915	0.126891	0	GO:0005813,centrosome;GO:0000785,chromatin;GO:0000781,chromosome, telomeric region;GO:0000307,cyclin-dependent protein kinase holoenzyme complex;GO:0070062,extracellular exosome;GO:0016604,nuclear body;GO:0005652,nuclear lamina;GO:0043596,nuclear replication fork;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0043626,PCNA complex;GO:0070557,PCNA-p21 complex;GO:0005657,replication fork;GO:0030894,replisome	GO:0003682,chromatin binding;GO:0003684,damaged DNA binding;GO:0032139,dinucleotide insertion or deletion binding;GO:0070182,DNA polymerase binding;GO:0030337,DNA polymerase processivity factor activity;GO:0019899,enzyme binding;GO:0030331,estrogen receptor binding;GO:0035035,histone acetyltransferase binding;GO:0042802,identical protein binding;GO:0032405,MutLalpha complex binding;GO:0008022,protein C-terminus binding;GO:0044877,protein-containing complex binding;GO:0000701,purine-specific mismatch base pair DNA N-glycosylase activity;GO:0030971,receptor tyrosine kinase binding	GO:0006287,base-excision repair, gap-filling;GO:0070301,cellular response to hydrogen peroxide;GO:0034644,cellular response to UV;GO:0071466,cellular response to xenobiotic stimulus;GO:0042769,DNA damage response, detection of DNA damage;GO:0006977,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0030855,epithelial cell differentiation;GO:0070987,error-free translesion synthesis;GO:0042276,error-prone translesion synthesis;GO:0044849,estrous cycle;GO:0007507,heart development;GO:0006272,leading strand elongation;GO:0097421,liver regeneration;GO:0006298,mismatch repair;GO:1902990,mitotic telomere maintenance via semi-conservative replication;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0006297,nucleotide-excision repair, DNA gap filling;GO:0033683,nucleotide-excision repair, DNA incision;GO:0006296,nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0032077,positive regulation of deoxyribonuclease activity;GO:0045739,positive regulation of DNA repair;GO:0045740,positive regulation of DNA replication;GO:1900264,positive regulation of DNA-directed DNA polymerase activity;GO:0016567,protein ubiquitination;GO:0000083,regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0031297,replication fork processing;GO:0046686,response to cadmium ion;GO:0071548,response to dexamethasone;GO:0032355,response to estradiol;GO:1902065,response to L-glutamate;GO:0000723,telomere maintenance;GO:0032201,telomere maintenance via semi-conservative replication;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0019985,translesion synthesis;GO:0016032,viral process	hsa:5111,path:hsa03030,DNA replication;hsa:5111,path:hsa03410,Base excision repair;hsa:5111,path:hsa03420,Nucleotide excision repair;hsa:5111,path:hsa03430,Mismatch repair;hsa:5111,path:hsa04110,Cell cycle;hsa:5111,path:hsa04530,Tight junction;hsa:5111,path:hsa05161,Hepatitis B
QCR1_HUMAN	P31930	UQCRC1	Cytochrome b-c1 complex subunit 1, mitochondrial	7.93368882	9.150275863	10.41387692	7.480770343	8.5419823415	8.9473236315	8.5419823415	8.9473236315	0.954696923158904	0.448769	0	1.04745283633176	0.448605	0	GO:0005743,mitochondrial inner membrane;GO:0005746,mitochondrial respirasome;GO:0005750,mitochondrial respiratory chain complex III;GO:0005739,mitochondrion	GO:0046872,metal ion binding;GO:0044877,protein-containing complex binding;GO:0008121,ubiquinol-cytochrome-c reductase activity;GO:0031625,ubiquitin protein ligase binding	GO:0009060,aerobic respiration;GO:0006122,mitochondrial electron transport, ubiquinol to cytochrome c;GO:0006119,oxidative phosphorylation;GO:0014823,response to activity;GO:0043279,response to alkaloid	hsa:7384,path:hsa00190,Oxidative phosphorylation;hsa:7384,path:hsa04260,Cardiac muscle contraction;hsa:7384,path:hsa04714,Thermogenesis;hsa:7384,path:hsa05010,Alzheimer disease;hsa:7384,path:hsa05012,Parkinson disease;hsa:7384,path:hsa05016,Huntington disease;hsa:7384,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
GNAQ_HUMAN	P50148	GNAQ	Guanine nucleotide-binding protein G(q) subunit alpha	0.449112355	0.146695155	0.506805204	1.599560444	0.297903755	1.053182824	0.297903755	1.053182824	0.282860438103765	0.052028	0	3.53531234945327	0.052251	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0005834,heterotrimeric G-protein complex;GO:0005765,lysosomal membrane;GO:0031965,nuclear membrane;GO:0001750,photoreceptor outer segment;GO:0005886,plasma membrane;GO:0045202,synapse	GO:0001664,G protein-coupled receptor binding;GO:0031683,G-protein beta/gamma-subunit complex binding;GO:0005525,GTP binding;GO:0005096,GTPase activator activity;GO:0003924,GTPase activity;GO:0046872,metal ion binding;GO:0031826,type 2A serotonin receptor binding;GO:0019001,guanyl nucleotide binding	GO:0001508,action potential;GO:0007202,activation of phospholipase C activity;GO:0007189,adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007188,adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007596,blood coagulation;GO:0009649,entrainment of circadian clock;GO:0007213,G protein-coupled acetylcholine receptor signaling pathway;GO:0007186,G protein-coupled receptor signaling pathway;GO:0007215,glutamate receptor signaling pathway;GO:0006469,negative regulation of protein kinase activity;GO:0007603,phototransduction, visible light;GO:0030168,platelet activation;GO:0050821,protein stabilization;GO:0060828,regulation of canonical Wnt signaling pathway	hsa:2776,path:hsa04015,Rap1 signaling pathway;hsa:2776,path:hsa04371,Apelin signaling pathway;hsa:2776,path:hsa04020,Calcium signaling pathway;hsa:2776,path:hsa04071,Sphingolipid signaling pathway;hsa:2776,path:hsa04022,cGMP-PKG signaling pathway;hsa:2776,path:hsa04540,Gap junction;hsa:2776,path:hsa04611,Platelet activation;hsa:2776,path:hsa04911,Insulin secretion;hsa:2776,path:hsa04922,Glucagon signaling pathway;hsa:2776,path:hsa04929,GnRH secretion;hsa:2776,path:hsa04912,GnRH signaling pathway;hsa:2776,path:hsa04915,Estrogen signaling pathway;hsa:2776,path:hsa04921,Oxytocin signaling pathway;hsa:2776,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:2776,path:hsa04918,Thyroid hormone synthesis;hsa:2776,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:2776,path:hsa04916,Melanogenesis;hsa:2776,path:hsa04924,Renin secretion;hsa:2776,path:hsa04925,Aldosterone synthesis and secretion;hsa:2776,path:hsa04927,Cortisol synthesis and secretion;hsa:2776,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:2776,path:hsa04270,Vascular smooth muscle contraction;hsa:2776,path:hsa04970,Salivary secretion;hsa:2776,path:hsa04971,Gastric acid secretion;hsa:2776,path:hsa04972,Pancreatic secretion;hsa:2776,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:2776,path:hsa04724,Glutamatergic synapse;hsa:2776,path:hsa04725,Cholinergic synapse;hsa:2776,path:hsa04728,Dopaminergic synapse;hsa:2776,path:hsa04726,Serotonergic synapse;hsa:2776,path:hsa04720,Long-term potentiation;hsa:2776,path:hsa04730,Long-term depression;hsa:2776,path:hsa04723,Retrograde endocannabinoid signaling;hsa:2776,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:2776,path:hsa04713,Circadian entrainment;hsa:2776,path:hsa05200,Pathways in cancer;hsa:2776,path:hsa05010,Alzheimer disease;hsa:2776,path:hsa05016,Huntington disease;hsa:2776,path:hsa05017,Spinocerebellar ataxia;hsa:2776,path:hsa04934,Cushing syndrome;hsa:2776,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:2776,path:hsa05163,Human cytomegalovirus infection;hsa:2776,path:hsa05146,Amoebiasis;hsa:2776,path:hsa05142,Chagas disease (American trypanosomiasis);hsa:2776,path:hsa05143,African trypanosomiasis
RET1_HUMAN	P09455	RBP1	Retinol-binding protein 1	0.323175044	0.458625037	0.119356474	0.135747417	0.3909000405	0.1275519455	0.3909000405	0.1275519455	3.06463409058704	0.133113	0	0.326303229175542	0.132553	0	GO:0005829,cytosol;GO:0005811,lipid droplet;GO:0005654,nucleoplasm;GO:0044297,cell body	GO:1904768,all-trans-retinol binding;GO:0016918,retinal binding;GO:0005501,retinoid binding;GO:0008289,lipid binding;GO:0019841,retinol binding	GO:0055088,lipid homeostasis;GO:0002138,retinoic acid biosynthetic process;GO:0001523,retinoid metabolic process;GO:0006776,vitamin A metabolic process;GO:0030852,regulation of granulocyte differentiation;GO:0033189,response to vitamin A;GO:0042572,retinol metabolic process	
VDAC3_HUMAN	Q9Y277	VDAC3	Voltage-dependent anion-selective channel protein 3	3.822230874	3.695473415	4.74213989	5.480512961	3.7588521445	5.1113264255	3.7588521445	5.1113264255	0.735396613635824	0.434330	0	1.35981044984144	0.434495	0	GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0046930,pore complex	GO:0000166,nucleotide binding;GO:0015288,porin activity;GO:0008308,voltage-gated anion channel activity	GO:0015853,adenine transport;GO:1902017,regulation of cilium assembly	hsa:7419,path:hsa04020,Calcium signaling pathway;hsa:7419,path:hsa04022,cGMP-PKG signaling pathway;hsa:7419,path:hsa04216,Ferroptosis;hsa:7419,path:hsa04217,Necroptosis;hsa:7419,path:hsa04218,Cellular senescence;hsa:7419,path:hsa04621,NOD-like receptor signaling pathway;hsa:7419,path:hsa04979,Cholesterol metabolism;hsa:7419,path:hsa05203,Viral carcinogenesis;hsa:7419,path:hsa05012,Parkinson disease;hsa:7419,path:hsa05016,Huntington disease;hsa:7419,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:7419,path:hsa05161,Hepatitis B
FA50A_HUMAN	Q14320	FAM50A	Protein FAM50A	0.091999145	0.049306904	0.061304036	0.189430859	0.0706530245	0.1253674475	0.0706530245	0.1253674475	0.56356754411866	0.283643	0	1.77441020235447	0.283943	0	GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003723,RNA binding	GO:0006325,chromatin organization;GO:0007283,spermatogenesis	
CY24A_HUMAN	P13498	CYBA	Cytochrome b-245 light chain	0.379603968	0.453699167	0.465959991	0.452251162	0.4166515675	0.4591055765	0.4166515675	0.4591055765	0.907528875332665	0.465707	0	1.10189331400991	0.465581	0	GO:0005789,endoplasmic reticulum membrane;GO:0016020,membrane;GO:0043020,NADPH oxidase complex;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0030141,secretory granule;GO:0035579,specific granule membrane;GO:0070821,tertiary granule membrane;GO:0016021,integral component of membrane;GO:0016324,apical plasma membrane;GO:0030425,dendrite;GO:0005768,endosome;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0043025,neuronal cell body;GO:0005634,nucleus;GO:0097038,perinuclear endoplasmic reticulum;GO:0001725,stress fiber	GO:0009055,electron transfer activity;GO:0020037,heme binding;GO:0046872,metal ion binding;GO:0046982,protein heterodimerization activity;GO:0017124,SH3 domain binding;GO:0016175,superoxide-generating NAD(P)H oxidase activity	GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0045454,cell redox homeostasis;GO:0034599,cellular response to oxidative stress;GO:0017004,cytochrome complex assembly;GO:0050665,hydrogen peroxide biosynthetic process;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0043312,neutrophil degranulation;GO:0031343,positive regulation of cell killing;GO:1900426,positive regulation of defense response to bacterium;GO:0032755,positive regulation of interleukin-6 production;GO:0050766,positive regulation of phagocytosis;GO:1903428,positive regulation of reactive oxygen species biosynthetic process;GO:0034137,positive regulation of toll-like receptor 2 signaling pathway;GO:0032760,positive regulation of tumor necrosis factor production;GO:0045730,respiratory burst;GO:0014895,smooth muscle hypertrophy;GO:0042554,superoxide anion generation;GO:0006801,superoxide metabolic process;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:1904385,cellular response to angiotensin;GO:0071480,cellular response to gamma radiation;GO:0071333,cellular response to glucose stimulus;GO:1904845,cellular response to L-glutamine;GO:0071260,cellular response to mechanical stimulus;GO:0071407,cellular response to organic cyclic compound;GO:0071356,cellular response to tumor necrosis factor;GO:0003106,negative regulation of glomerular filtration by angiotensin;GO:0030307,positive regulation of cell growth;GO:0001938,positive regulation of endothelial cell proliferation;GO:0070257,positive regulation of mucus secretion;GO:0033864,positive regulation of NAD(P)H oxidase activity;GO:0048661,positive regulation of smooth muscle cell proliferation;GO:0032930,positive regulation of superoxide anion generation;GO:0051279,regulation of release of sequestered calcium ion into cytosol;GO:0014823,response to activity;GO:1904044,response to aldosterone;GO:0042493,response to drug;GO:0001666,response to hypoxia;GO:0070555,response to interleukin-1;GO:0031667,response to nutrient levels	hsa:1535,path:hsa04145,Phagosome;hsa:1535,path:hsa04621,NOD-like receptor signaling pathway;hsa:1535,path:hsa04670,Leukocyte transendothelial migration;hsa:1535,path:hsa04380,Osteoclast differentiation;hsa:1535,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:1535,path:hsa05140,Leishmaniasis
P4K2A_HUMAN	Q9BTU6	PI4K2A	Phosphatidylinositol 4-kinase type 2-alpha	0.549712821	0.489302585	0.571159348	0.505514086	0.519507703	0.538336717	0.519507703	0.538336717	0.965023723247174	0.445183	0	1.03624395536634	0.445012	0	GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0030425,dendrite;GO:0005768,endosome;GO:0035838,growing cell tip;GO:0005887,integral component of plasma membrane;GO:0031224,intrinsic component of membrane;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0045121,membrane raft;GO:0005739,mitochondrion;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0043204,perikaryon;GO:0005886,plasma membrane;GO:0042734,presynaptic membrane;GO:0005802,trans-Golgi network	GO:0004430,1-phosphatidylinositol 4-kinase activity;GO:0035651,AP-3 adaptor complex binding;GO:0005524,ATP binding;GO:0000287,magnesium ion binding	GO:0007032,endosome organization;GO:0007030,Golgi organization;GO:0006661,phosphatidylinositol biosynthetic process;GO:0046854,phosphatidylinositol phosphorylation	hsa:55361,path:hsa00562,Inositol phosphate metabolism;hsa:55361,path:hsa04070,Phosphatidylinositol signaling system
WNK1_HUMAN	Q9H4A3	WNK1	Serine/threonine-protein kinase WNK1	0.731638303	0.955903688	0.970969106	1.250890578	0.8437709955	1.110929842	0.8437709955	1.110929842	0.759517805355705	0.453811	0	1.31662482821146	0.453954	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane	GO:0005524,ATP binding;GO:0019869,chloride channel inhibitor activity;GO:0019902,phosphatase binding;GO:0019870,potassium channel inhibitor activity;GO:0030295,protein kinase activator activity;GO:0004672,protein kinase activity;GO:0019901,protein kinase binding;GO:0004860,protein kinase inhibitor activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity	GO:1990869,cellular response to chemokine;GO:0038116,chemokine (C-C motif) ligand 21 signaling pathway;GO:0035556,intracellular signal transduction;GO:0050801,ion homeostasis;GO:0006811,ion transport;GO:0097022,lymphocyte migration into lymph node;GO:0033633,negative regulation of cell-cell adhesion mediated by integrin;GO:0034260,negative regulation of GTPase activity;GO:0034115,negative regulation of heterotypic cell-cell adhesion;GO:1903038,negative regulation of leukocyte cell-cell adhesion;GO:0010923,negative regulation of phosphatase activity;GO:0010766,negative regulation of sodium ion transport;GO:0048666,neuron development;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:1903288,positive regulation of potassium ion import across plasma membrane;GO:2000651,positive regulation of sodium ion transmembrane transporter activity;GO:0010820,positive regulation of T cell chemotaxis;GO:0006468,protein phosphorylation;GO:1904062,regulation of cation transmembrane transport;GO:0050794,regulation of cellular process;GO:0002028,regulation of sodium ion transport;GO:0007165,signal transduction;GO:0050852,T cell receptor signaling pathway	
NDUA6_HUMAN	P56556	NDUFA6	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	0.059275724	0.262047021	0.44206638	0.069371434	0.1606613725	0.255718907	0.1606613725	0.255718907	0.628273342729406	0.342388	0	1.59166390166373	0.342643	0	GO:0005743,mitochondrial inner membrane;GO:0031966,mitochondrial membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0070469,respirasome	GO:0008137,NADH dehydrogenase (ubiquinone) activity	GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0006979,response to oxidative stress	hsa:4700,path:hsa00190,Oxidative phosphorylation;hsa:4700,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4700,path:hsa04714,Thermogenesis;hsa:4700,path:hsa05010,Alzheimer disease;hsa:4700,path:hsa05012,Parkinson disease;hsa:4700,path:hsa05016,Huntington disease;hsa:4700,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
BCAT2_HUMAN	O15382	BCAT2	Branched-chain-amino-acid aminotransferase, mitochondrial	0.459115591	0.311086266	1.760774888	0.397872089	0.3851009285	1.0793234885	0.3851009285	1.0793234885	0.356798432169023	0.101931	0	2.80270289844289	0.102232	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0004084,branched-chain-amino-acid transaminase activity;GO:0052656,L-isoleucine transaminase activity;GO:0052654,L-leucine transaminase activity;GO:0050048,L-leucine;GO:0052655,L-valine transaminase activity;GO:0003824,catalytic activity	GO:0009082,branched-chain amino acid biosynthetic process;GO:0009083,branched-chain amino acid catabolic process;GO:0009098,leucine biosynthetic process;GO:0009099,valine biosynthetic process;GO:0008652,cellular amino acid biosynthetic process;GO:1990830,cellular response to leukemia inhibitory factor;GO:0006550,isoleucine catabolic process;GO:0006551,leucine metabolic process;GO:0010817,regulation of hormone levels;GO:0006573,valine metabolic process	hsa:587,path:hsa00270,Cysteine and methionine metabolism;hsa:587,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:587,path:hsa00290,Valine, leucine and isoleucine biosynthesis;hsa:587,path:hsa00770,Pantothenate and CoA biosynthesis
RANB3_HUMAN	Q9H6Z4	RANBP3	Ran-binding protein 3	0.274758618	0.181668946	0.322881193	0.185673177	0.228213782	0.254277185	0.228213782	0.254277185	0.897500033280611	0.469431	0	1.11420608681732	0.469313	0	GO:0005737,cytoplasm;GO:0005643,nuclear pore;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0070412,R-SMAD binding;GO:0031267,small GTPase binding	GO:0043547,positive regulation of GTPase activity;GO:0006611,protein export from nucleus;GO:0046907,intracellular transport	hsa:8498,path:hsa05166,Human T-cell leukemia virus 1 infection
QCR9_HUMAN	Q9UDW1	UQCR10	Cytochrome b-c1 complex subunit 9	0.478944671	0.576852408	0.3838575	0.253225553	0.5278985395	0.3185415265	0.5278985395	0.3185415265	1.65723617043067	0.276382	0	0.603414297758253	0.275897	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005750,mitochondrial respiratory chain complex III	GO:0008121,ubiquinol-cytochrome-c reductase activity	GO:0009060,aerobic respiration;GO:0006122,mitochondrial electron transport, ubiquinol to cytochrome c	hsa:29796,path:hsa00190,Oxidative phosphorylation;hsa:29796,path:hsa04260,Cardiac muscle contraction;hsa:29796,path:hsa04714,Thermogenesis;hsa:29796,path:hsa05010,Alzheimer disease;hsa:29796,path:hsa05012,Parkinson disease;hsa:29796,path:hsa05016,Huntington disease;hsa:29796,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
CRYM_HUMAN	Q14894	CRYM	Ketimine reductase mu-crystallin	0.99158803	0.316501027	0.417493767	0.342433823	0.6540445285	0.379963795	0.6540445285	0.379963795	1.72133381418616	0.265786	0	0.580944841586577	0.265287	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005782,peroxisomal matrix;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle	GO:0042562,hormone binding;GO:0050661,NADP binding;GO:0042803,protein homodimerization activity;GO:0047127,thiomorpholine-carboxylate dehydrogenase activity;GO:0070324,thyroid hormone binding;GO:0003714,transcription corepressor activity;GO:0042626,ATPase-coupled transmembrane transporter activity;GO:0005319,lipid transporter activity	GO:0006554,lysine catabolic process;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0007605,sensory perception of sound;GO:0042403,thyroid hormone metabolic process;GO:0070327,thyroid hormone transport;GO:0006869,lipid transport	
ANFY1_HUMAN	Q9P2R3	ANKFY1	Rabankyrin-5	0.989320507	1.169971229	1.502759849	2.467964212	1.079645868	1.9853620305	1.079645868	1.9853620305	0.543803020010461	0.265457	0	1.83890115207665	0.265768	0	GO:0005829,cytosol;GO:0005769,early endosome;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0005765,lysosomal membrane;GO:0044354,macropinosome;GO:0016020,membrane	GO:0046872,metal ion binding;GO:1901981,phosphatidylinositol phosphate binding;GO:0031267,small GTPase binding	GO:0006897,endocytosis;GO:0016197,endosomal transport;GO:0034058,endosomal vesicle fusion;GO:0090160,Golgi to lysosome transport;GO:0048549,positive regulation of pinocytosis;GO:0042147,retrograde transport, endosome to Golgi	
PPIL1_HUMAN	Q9Y3C6	PPIL1	Peptidyl-prolyl cis-trans isomerase-like 1	1.042634358	0.613901056	0.135978437	0.036752095	0.828267707	0.086365266	0.828267707	0.086365266	9.59028722264342	0.019070	1	0.104272163782428	0.018850	-1	GO:0071013,catalytic step 2 spliceosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0071007,U2-type catalytic step 2 spliceosome	GO:0016018,cyclosporin A binding;GO:0097718,disordered domain specific binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity	GO:0000398,mRNA splicing, via spliceosome;GO:0006457,protein folding;GO:0000413,protein peptidyl-prolyl isomerization	hsa:51645,path:hsa03040,Spliceosome
SURF1_HUMAN	Q15526	SURF1	Surfeit locus protein 1	0.04572491	0.057989355	0.089205806	2.55E-05	0.0518571325	0.044615653	0.0518571325	0.044615653	1.16230804690901	0.384141	0	0.860357116737992	0.383842	0	GO:0016021,integral component of membrane;GO:0005746,mitochondrial respirasome;GO:0005743,mitochondrial inner membrane	GO:0004129,cytochrome-c oxidase activity	GO:0009060,aerobic respiration;GO:0033617,mitochondrial cytochrome c oxidase assembly;GO:0006119,oxidative phosphorylation;GO:0008535,respiratory chain complex IV assembly	
ERGI1_HUMAN	Q969X5	ERGIC1	Endoplasmic reticulum-Golgi intermediate compartment protein 1	2.091121229	2.168861891	1.278383142	1.497712448	2.12999156	1.388047795	2.12999156	1.388047795	1.53452321142875	0.298479	0	0.651668213652452	0.298026	0	GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005783,endoplasmic reticulum;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0030173,integral component of Golgi membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0016021,integral component of membrane		GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	
TACO1_HUMAN	Q9BSH4	TACO1	Translational activator of cytochrome c oxidase 1	0.080801316	0.054805532	2.55E-05	0.053694714	0.067803424	0.026860107	0.067803424	0.026860107	2.524316973123	0.171485	0	0.396146763915639	0.170914	0	GO:0005739,mitochondrion	GO:0097177,mitochondrial ribosome binding;GO:0003729,mRNA binding;GO:0019843,rRNA binding	GO:0033617,mitochondrial cytochrome c oxidase assembly;GO:0061743,motor learning;GO:1904959,regulation of cytochrome-c oxidase activity;GO:0070129,regulation of mitochondrial translation	
AT2B4_HUMAN	P23634	ATP2B4	Plasma membrane calcium-transporting ATPase 4	0.236092362	0.364582148	0.593384898	0.917080417	0.300337255	0.7552326575	0.300337255	0.7552326575	0.397675142907866	0.134608	0	2.51461530305323	0.134933	0	GO:0016323,basolateral plasma membrane;GO:0005901,caveola;GO:0098978,glutamatergic synapse;GO:0005887,integral component of plasma membrane;GO:0099059,integral component of presynaptic active zone membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0045121,membrane raft;GO:0043005,neuron projection;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0036126,sperm flagellum;GO:0097228,sperm principal piece;GO:0030315,T-tubule;GO:0030018,Z disc;GO:0016021,integral component of membrane	GO:0005524,ATP binding;GO:0019829,ATPase-coupled cation transmembrane transporter activity;GO:0015085,calcium ion transmembrane transporter activity;GO:0048306,calcium-dependent protein binding;GO:0005516,calmodulin binding;GO:0046872,metal ion binding;GO:0050998,nitric-oxide synthase binding;GO:0036487,nitric-oxide synthase inhibitor activity;GO:0005388,P-type calcium transporter activity;GO:0030165,PDZ domain binding;GO:0019901,protein kinase binding;GO:0030346,protein phosphatase 2B binding;GO:0097110,scaffold protein binding;GO:0017080,sodium channel regulator activity	GO:1901660,calcium ion export;GO:0098703,calcium ion import across plasma membrane;GO:0097553,calcium ion transmembrane import into cytosol;GO:0070588,calcium ion transmembrane transport;GO:0006874,cellular calcium ion homeostasis;GO:1905145,cellular response to acetylcholine;GO:0071872,cellular response to epinephrine stimulus;GO:0030317,flagellated sperm motility;GO:0021766,hippocampus development;GO:0034220,ion transmembrane transport;GO:0140199,negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process;GO:0016525,negative regulation of angiogenesis;GO:1900082,negative regulation of arginine catabolic process;GO:0043537,negative regulation of blood vessel endothelial cell migration;GO:0070885,negative regulation of calcineurin-NFAT signaling cascade;GO:1903243,negative regulation of cardiac muscle hypertrophy in response to stress;GO:1902548,negative regulation of cellular response to vascular endothelial growth factor stimulus;GO:1903249,negative regulation of citrulline biosynthetic process;GO:0010629,negative regulation of gene expression;GO:0045019,negative regulation of nitric oxide biosynthetic process;GO:0010751,negative regulation of nitric oxide mediated signal transduction;GO:0051001,negative regulation of nitric-oxide synthase activity;GO:1902083,negative regulation of peptidyl-cysteine S-nitrosylation;GO:0098736,negative regulation of the force of heart contraction;GO:0003407,neural retina development;GO:2000481,positive regulation of cAMP-dependent protein kinase activity;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:1903078,positive regulation of protein localization to plasma membrane;GO:1903779,regulation of cardiac conduction;GO:1902806,regulation of cell cycle G1/S phase transition;GO:0051480,regulation of cytosolic calcium ion concentration;GO:1902305,regulation of sodium ion transmembrane transport;GO:0006357,regulation of transcription by RNA polymerase II;GO:0051599,response to hydrostatic pressure;GO:0007283,spermatogenesis;GO:0150104,transport across blood-brain barrier;GO:0014832,urinary bladder smooth muscle contraction	hsa:493,path:hsa04020,Calcium signaling pathway;hsa:493,path:hsa04024,cAMP signaling pathway;hsa:493,path:hsa04022,cGMP-PKG signaling pathway;hsa:493,path:hsa04925,Aldosterone synthesis and secretion;hsa:493,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:493,path:hsa04970,Salivary secretion;hsa:493,path:hsa04972,Pancreatic secretion;hsa:493,path:hsa04978,Mineral absorption;hsa:493,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption
NAMPT_HUMAN	P43490	NAMPT	Nicotinamide phosphoribosyltransferase	7.248761887	17.91042446	11.68328108	6.179607985	12.5795931735	8.9314445325	12.5795931735	8.9314445325	1.4084612100232	0.324005	0	0.70999470406681	0.323594	0	GO:0030054,cell junction;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016607,nuclear speck;GO:0005737,cytoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0005125,cytokine activity;GO:0042802,identical protein binding;GO:0047280,nicotinamide phosphoribosyltransferase activity;GO:0004514,nicotinate-nucleotide diphosphorylase (carboxylating) activity;GO:0000166,nucleotide binding	GO:0007267,cell-cell signaling;GO:0032922,circadian regulation of gene expression;GO:0034356,NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0008284,positive regulation of cell population proliferation;GO:0051770,positive regulation of nitric-oxide synthase biosynthetic process;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0007165,signal transduction;GO:0009435,NAD biosynthetic process;GO:0007568,aging;GO:1904646,cellular response to amyloid-beta;GO:0071479,cellular response to ionizing radiation;GO:0090650,cellular response to oxygen-glucose deprivation;GO:0007565,female pregnancy;GO:0001774,microglial cell activation;GO:0010507,negative regulation of autophagy;GO:2000773,negative regulation of cellular senescence;GO:0070997,neuron death;GO:0048661,positive regulation of smooth muscle cell proliferation;GO:0014916,regulation of lung blood pressure;GO:1905377,response to D-galactose;GO:0014070,response to organic cyclic compound	hsa:10135,path:hsa00760,Nicotinate and nicotinamide metabolism;hsa:10135,path:hsa04621,NOD-like receptor signaling pathway
SUN1_HUMAN	O94901	SUN1	SUN domain-containing protein 1	0.181674066	0.357988709	0.129254872	0.320524348	0.2698313875	0.22488961	0.2698313875	0.22488961	1.19983927892445	0.373951	0	0.833444960142007	0.373631	0	GO:0005639,integral component of nuclear inner membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0034993,meiotic nuclear membrane microtubule tethering complex;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0005737,cytoplasm	GO:0140444,cytoskeleton-nuclear membrane anchor activity;GO:0043495,protein-membrane adaptor activity;GO:0005521,lamin binding	GO:0030154,cell differentiation;GO:0051321,meiotic cell cycle;GO:0006998,nuclear envelope organization;GO:0090292,nuclear matrix anchoring at nuclear membrane;GO:0007283,spermatogenesis;GO:0051642,centrosome localization;GO:0007129,homologous chromosome pairing at meiosis;GO:0070197,meiotic attachment of telomere to nuclear envelope;GO:0021817,nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration;GO:0001503,ossification;GO:0009612,response to mechanical stimulus	
HDGF_HUMAN	P51858	HDGF	Hepatoma-derived growth factor	1.742298309	2.444094258	2.786487658	1.340976495	2.0931962835	2.0637320765	2.0931962835	2.0637320765	1.01427714737563	0.428656	0	0.985923820316204	0.428449	0	GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0017053,transcription repressor complex	GO:0003779,actin binding;GO:0003690,double-stranded DNA binding;GO:0008083,growth factor activity;GO:0008201,heparin binding;GO:0000166,nucleotide binding;GO:0003723,RNA binding;GO:0003712,transcription coregulator activity;GO:0003714,transcription corepressor activity;GO:0001222,transcription corepressor binding;GO:0015631,tubulin binding	GO:0098761,cellular response to interleukin-7;GO:0036498,IRE1-mediated unfolded protein response;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0051781,positive regulation of cell division;GO:0006357,regulation of transcription by RNA polymerase II;GO:0007165,signal transduction	
ANXA1_HUMAN	P04083	ANXA1	Annexin A1	24.90394028	67.99700704	48.22578427	66.81000535	46.45047366	57.51789481	46.45047366	57.51789481	0.807582993317832	0.491119	0	1.23826282657545	0.491220	0	GO:0005912,adherens junction;GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0001533,cornified envelope;GO:0005737,cytoplasm;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0031313,extrinsic component of endosome membrane;GO:0031232,extrinsic component of external side of plasma membrane;GO:0019898,extrinsic component of membrane;GO:0005925,focal adhesion;GO:0016328,lateral plasma membrane;GO:0042629,mast cell granule;GO:0031966,mitochondrial membrane;GO:0031514,motile cilium;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0001891,phagocytic cup;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0042383,sarcolemma;GO:0097060,synaptic membrane;GO:0031982,vesicle;GO:0005929,cilium;GO:0005769,early endosome;GO:0010008,endosome membrane	GO:0098641,cadherin binding involved in cell-cell adhesion;GO:0005509,calcium ion binding;GO:0005544,calcium-dependent phospholipid binding;GO:0048306,calcium-dependent protein binding;GO:1990814,DNA/DNA annealing activity;GO:0036121,double-stranded DNA helicase activity;GO:0042802,identical protein binding;GO:0019834,phospholipase A2 inhibitor activity;GO:0005543,phospholipid binding;GO:0005102,signaling receptor binding;GO:0003697,single-stranded DNA binding;GO:0003727,single-stranded RNA binding	GO:0031532,actin cytoskeleton reorganization;GO:0002250,adaptive immune response;GO:0046632,alpha-beta T cell differentiation;GO:0050482,arachidonic acid secretion;GO:0007166,cell surface receptor signaling pathway;GO:0071385,cellular response to glucocorticoid stimulus;GO:0070301,cellular response to hydrogen peroxide;GO:0035924,cellular response to vascular endothelial growth factor stimulus;GO:0019221,cytokine-mediated signaling pathway;GO:0032508,DNA duplex unwinding;GO:0031018,endocrine pancreas development;GO:0007186,G protein-coupled receptor signaling pathway;GO:0007187,G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0042063,gliogenesis;GO:0071621,granulocyte chemotaxis;GO:0070365,hepatocyte differentiation;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0030073,insulin secretion;GO:0030216,keratinocyte differentiation;GO:0002548,monocyte chemotaxis;GO:0014839,myoblast migration involved in skeletal muscle regeneration;GO:0043066,negative regulation of apoptotic process;GO:0045920,negative regulation of exocytosis;GO:0032717,negative regulation of interleukin-8 production;GO:1900138,negative regulation of phospholipase A2 activity;GO:0050709,negative regulation of protein secretion;GO:0045629,negative regulation of T-helper 2 cell differentiation;GO:0097350,neutrophil clearance;GO:0001780,neutrophil homeostasis;GO:0018149,peptide cross-linking;GO:0006909,phagocytosis;GO:0090050,positive regulation of cell migration involved in sprouting angiogenesis;GO:1900087,positive regulation of G1/S transition of mitotic cell cycle;GO:0032743,positive regulation of interleukin-2 production;GO:0033031,positive regulation of neutrophil apoptotic process;GO:0031394,positive regulation of prostaglandin biosynthetic process;GO:0042102,positive regulation of T cell proliferation;GO:0045627,positive regulation of T-helper 1 cell differentiation;GO:0031340,positive regulation of vesicle fusion;GO:0090303,positive regulation of wound healing;GO:0070459,prolactin secretion;GO:0030850,prostate gland development;GO:0008360,regulation of cell shape;GO:0046883,regulation of hormone secretion;GO:0050727,regulation of inflammatory response;GO:0032652,regulation of interleukin-1 production;GO:0002685,regulation of leukocyte migration;GO:0042493,response to drug;GO:0032355,response to estradiol;GO:0070555,response to interleukin-1;GO:0043434,response to peptide hormone;GO:0010165,response to X-ray;GO:0007165,signal transduction	
TM165_HUMAN	Q9HC07	TMEM165	Transmembrane protein 165	0.103042314	1.000431482	0.189940575	2.55E-05	0.551736898	0.0949830375	0.551736898	0.0949830375	5.80879399650701	0.049394	1	0.172152773983951	0.049006	-1	GO:0031901,early endosome membrane;GO:0010008,endosome membrane;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0032588,trans-Golgi network membrane	GO:0015085,calcium ion transmembrane transporter activity;GO:0005384,manganese ion transmembrane transporter activity;GO:0046873,metal ion transmembrane transporter activity	GO:0070588,calcium ion transmembrane transport;GO:0006874,cellular calcium ion homeostasis;GO:0032468,Golgi calcium ion homeostasis;GO:0032472,Golgi calcium ion transport;GO:0071421,manganese ion transmembrane transport;GO:0006487,protein N-linked glycosylation;GO:0035751,regulation of lysosomal lumen pH	
E41L2_HUMAN	O43491	EPB41L2	Band 4.1-like protein 2	1.895420433	2.061943099	1.71003635	5.441781468	1.978681766	3.575908909	1.978681766	3.575908909	0.55333673657625	0.274236	0	1.8072178004798	0.274542	0	GO:0099738,cell cortex region;GO:0030054,cell junction;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0008091,spectrin	GO:0003779,actin binding;GO:0042731,PH domain binding;GO:0030507,spectrin binding;GO:0005198,structural molecule activity;GO:0008092,cytoskeletal protein binding	GO:0031032,actomyosin structure organization;GO:0007049,cell cycle;GO:0051301,cell division;GO:0030866,cortical actin cytoskeleton organization;GO:1904778,positive regulation of protein localization to cell cortex	
DIP2A_HUMAN	Q14689	DIP2A	Disco-interacting protein 2 homolog A	0.070975345	0.115518534	0.004321591	2.55E-05	0.0932469395	0.0021735455	0.0932469395	0.0021735455	42.9008454159345	0.000425	1	0.0233095639562519	0.000413	-1	GO:0009986,cell surface;GO:0043197,dendritic spine;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005886,plasma membrane	GO:0003987,acetate-CoA ligase activity	GO:0006085,acetyl-CoA biosynthetic process;GO:0060997,dendritic spine morphogenesis;GO:0010629,negative regulation of gene expression;GO:2000758,positive regulation of peptidyl-lysine acetylation	
APMAP_HUMAN	Q9HDC9	APMAP	Adipocyte plasma membrane-associated protein	5.789584291	7.819604423	8.061537429	9.171453047	6.804594357	8.616495238	6.804594357	8.616495238	0.789717184196974	0.477491	0	1.26627610492844	0.477607	0	GO:0009986,cell surface;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0004064,arylesterase activity;GO:0016844,strictosidine synthase activity	GO:0009058,biosynthetic process	
CLPP_HUMAN	Q16740	CLPP	ATP-dependent Clp protease proteolytic subunit, mitochondrial	1.650911921	0.830450449	0.46641894	0.088604317	1.240681185	0.2775116285	1.240681185	0.2775116285	4.47073584521882	0.076347	0	0.223676825162783	0.075872	0	GO:0009368,endopeptidase Clp complex;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0004176,ATP-dependent peptidase activity;GO:0051117,ATPase binding;GO:0004175,endopeptidase activity;GO:0042802,identical protein binding;GO:0008233,peptidase activity;GO:0004252,serine-type endopeptidase activity	GO:0033619,membrane protein proteolysis;GO:0006515,protein quality control for misfolded or incompletely synthesized proteins;GO:0051603,proteolysis involved in cellular protein catabolic process	
WDR13_HUMAN	Q9H1Z4	WDR13	WD repeat-containing protein 13	0.11613968	0.081671278	0.129374856	0.245417274	0.098905479	0.187396065	0.098905479	0.187396065	0.527788451694543	0.250699	0	1.89469852322337	0.251018	0	GO:0034451,centriolar satellite;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:1990841,promoter-specific chromatin binding	GO:1904691,negative regulation of type B pancreatic cell proliferation	
PPP6_HUMAN	O00743	PPP6C	Serine/threonine-protein phosphatase 6 catalytic subunit	0.162075391	0.127352922	0.18312873	0.053891327	0.1447141565	0.1185100285	0.1447141565	0.1185100285	1.22111316933824	0.368352	0	0.818924916305614	0.368022	0	GO:0005829,cytosol;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0046872,metal ion binding;GO:0106306,protein serine phosphatase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0106307,protein threonine phosphatase activity	GO:0048208,COPII vesicle coating;GO:0000082,G1/S transition of mitotic cell cycle;GO:0045087,innate immune response;GO:0006470,protein dephosphorylation;GO:0007004,telomere maintenance via telomerase	
PDCD4_HUMAN	Q53EL6	PDCD4	Programmed cell death protein 4	0.187889783	0.250085345	0.72070874	0.465766533	0.218987564	0.5932376365	0.218987564	0.5932376365	0.369139701405307	0.111487	0	2.70900148695202	0.111796	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus	GO:0003723,RNA binding	GO:0006915,apoptotic process;GO:0030509,BMP signaling pathway;GO:0007569,cell aging;GO:0071222,cellular response to lipopolysaccharide;GO:0060940,epithelial to mesenchymal transition involved in cardiac fibroblast development;GO:0035722,interleukin-12-mediated signaling pathway;GO:0043066,negative regulation of apoptotic process;GO:0045786,negative regulation of cell cycle;GO:1900016,negative regulation of cytokine production involved in inflammatory response;GO:0043508,negative regulation of JUN kinase activity;GO:1904761,negative regulation of myofibroblast differentiation;GO:0045892,negative regulation of transcription, DNA-templated;GO:1905064,negative regulation of vascular associated smooth muscle cell differentiation;GO:1904706,negative regulation of vascular associated smooth muscle cell proliferation;GO:2000353,positive regulation of endothelial cell apoptotic process;GO:0050729,positive regulation of inflammatory response;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:1905461,positive regulation of vascular associated smooth muscle cell apoptotic process	hsa:27250,path:hsa05206,MicroRNAs in cancer;hsa:27250,path:hsa05205,Proteoglycans in cancer
HNRPD_HUMAN	Q14103	HNRNPD	Heterogeneous nuclear ribonucleoprotein D0	8.066333255	8.658364685	12.98260171	5.660064209	8.36234897	9.3213329595	8.36234897	9.3213329595	0.897119436279482	0.469573	0	1.11467878139747	0.469456	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0045202,synapse;GO:0005737,cytoplasm	GO:0003682,chromatin binding;GO:0042826,histone deacetylase binding;GO:0003680,minor groove of adenine-thymine-rich DNA binding;GO:0035925,mRNA 3'-UTR AU-rich region binding;GO:0003723,RNA binding;GO:0042162,telomeric DNA binding;GO:0008134,transcription factor binding	GO:0061158,3'-UTR-mediated mRNA destabilization;GO:0071230,cellular response to amino acid stimulus;GO:0071392,cellular response to estradiol stimulus;GO:0071732,cellular response to nitric oxide;GO:1904586,cellular response to putrescine;GO:0021549,cerebellum development;GO:0097167,circadian regulation of translation;GO:1990828,hepatocyte dedifferentiation;GO:0001889,liver development;GO:0000398,mRNA splicing, via spliceosome;GO:0048255,mRNA stabilization;GO:0042789,mRNA transcription by RNA polymerase II;GO:1905663,positive regulation of telomerase RNA reverse transcriptase activity;GO:1904355,positive regulation of telomere capping;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0045727,positive regulation of translation;GO:0042752,regulation of circadian rhythm;GO:0010468,regulation of gene expression;GO:0043488,regulation of mRNA stability;GO:0032204,regulation of telomere maintenance;GO:0006355,regulation of transcription, DNA-templated;GO:0051592,response to calcium ion;GO:0051602,response to electrical stimulus;GO:1901355,response to rapamycin;GO:1904383,response to sodium phosphate;GO:0006401,RNA catabolic process;GO:0016070,RNA metabolic process;GO:0006396,RNA processing	
MSH6_HUMAN	P52701	MSH6	DNA mismatch repair protein Msh6	0.339799946	0.119072652	0.398486792	0.21579633	0.229436299	0.307141561	0.229436299	0.307141561	0.747005056082267	0.443767	0	1.33867902480418	0.443921	0	GO:0000785,chromatin;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0032300,mismatch repair complex;GO:0032301,MutSalpha complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005694,chromosome	GO:0005524,ATP binding;GO:0008094,ATPase activity, acting on DNA;GO:0003682,chromatin binding;GO:0003684,damaged DNA binding;GO:0019899,enzyme binding;GO:0032137,guanine/thymine mispair binding;GO:0035064,methylated histone binding;GO:0030983,mismatched DNA binding	GO:0008340,determination of adult lifespan;GO:0006281,DNA repair;GO:0036297,interstrand cross-link repair;GO:0097193,intrinsic apoptotic signaling pathway;GO:0008630,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0045190,isotype switching;GO:0000710,meiotic mismatch repair;GO:0006298,mismatch repair;GO:0045910,negative regulation of DNA recombination;GO:0051096,positive regulation of helicase activity;GO:0006290,pyrimidine dimer repair;GO:0009411,response to UV;GO:0016446,somatic hypermutation of immunoglobulin genes;GO:0016447,somatic recombination of immunoglobulin gene segments;GO:0016032,viral process	hsa:2956,path:hsa03430,Mismatch repair;hsa:2956,path:hsa05200,Pathways in cancer;hsa:2956,path:hsa05210,Colorectal cancer;hsa:2956,path:hsa01524,Platinum drug resistance
PLCH1_HUMAN	Q4KWH8	PLCH1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1	1.008942448	0.419421076	0.991462741	0.662839971	0.714181762	0.827151356	0.714181762	0.827151356	0.863423310400763	0.482423	0	1.15818045210737	0.482333	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0005886,plasma membrane	GO:0005509,calcium ion binding;GO:0050429,calcium-dependent phospholipase C activity;GO:0004435,phosphatidylinositol phospholipase C activity	GO:0043647,inositol phosphate metabolic process;GO:0016042,lipid catabolic process;GO:0048015,phosphatidylinositol-mediated signaling	hsa:23007,path:hsa00562,Inositol phosphate metabolism
MTCH2_HUMAN	Q9Y6C9	MTCH2	Mitochondrial carrier homolog 2	2.678443736	3.431178092	2.14500638	1.124240609	3.054810914	1.6346234945	3.054810914	1.6346234945	1.86881622849451	0.243560	0	0.535098092981345	0.243035	0	GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0005634,nucleus		GO:0043065,positive regulation of apoptotic process;GO:0070585,protein localization to mitochondrion	
CO4A2_HUMAN	P08572	COL4A2	Collagen alpha-2(IV) chain	2.063909945	2.878585011	3.761399091	28.41697264	2.471247478	16.0891858655	2.471247478	16.0891858655	0.153596800898366	0.005254	-1	6.5105522650937	0.005302	1	GO:0005587,collagen type IV trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005604,basement membrane;GO:0005581,collagen trimer;GO:0016020,membrane	GO:0005201,extracellular matrix structural constituent;GO:0030020,extracellular matrix structural constituent conferring tensile strength	GO:0007568,aging;GO:0001525,angiogenesis;GO:0071560,cellular response to transforming growth factor beta stimulus;GO:0030199,collagen fibril organization;GO:0038063,collagen-activated tyrosine kinase receptor signaling pathway;GO:0035987,endodermal cell differentiation;GO:0030198,extracellular matrix organization;GO:0016525,negative regulation of angiogenesis;GO:0014823,response to activity;GO:0006351,transcription, DNA-templated	hsa:1284,path:hsa04151,PI3K-Akt signaling pathway;hsa:1284,path:hsa04512,ECM-receptor interaction;hsa:1284,path:hsa04510,Focal adhesion;hsa:1284,path:hsa04926,Relaxin signaling pathway;hsa:1284,path:hsa04974,Protein digestion and absorption;hsa:1284,path:hsa05200,Pathways in cancer;hsa:1284,path:hsa05222,Small cell lung cancer;hsa:1284,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:1284,path:hsa05165,Human papillomavirus infection;hsa:1284,path:hsa05146,Amoebiasis
DTD1_HUMAN	Q8TEA8	DTD1	D-aminoacyl-tRNA deacylase 1	0.769656106	0.5393132	0.084839901	2.55E-05	0.654484653	0.0424327005	0.654484653	0.0424327005	15.4240631703372	0.006683	1	0.0648337593639495	0.006578	-1	GO:0005737,cytoplasm;GO:0005634,nucleus	GO:0051500,D-tyrosyl-tRNA(Tyr) deacylase activity;GO:0003677,DNA binding;GO:0046872,metal ion binding;GO:0000049,tRNA binding;GO:0051499,D-aminoacyl-tRNA deacylase activity	GO:0006260,DNA replication;GO:0006399,tRNA metabolic process	
FLNB_HUMAN	O75369	FLNB	Filamin-B	11.20195623	15.47648371	13.16808854	26.56212967	13.33921997	19.865109105	13.33921997	19.865109105	0.671489892126621	0.380453	0	1.48922569308226	0.380673	0	GO:0015629,actin cytoskeleton;GO:0005938,cell cortex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016021,integral component of membrane;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0030018,Z disc	GO:0003779,actin binding;GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0003723,RNA binding	GO:0030036,actin cytoskeleton organization;GO:0030154,cell differentiation;GO:0007517,muscle organ development;GO:0007165,signal transduction	hsa:2317,path:hsa04010,MAPK signaling pathway;hsa:2317,path:hsa04510,Focal adhesion;hsa:2317,path:hsa05205,Proteoglycans in cancer;hsa:2317,path:hsa05132,Salmonella infection
S10AA_HUMAN	P60903	S100A10	Protein S100-A10	3.117733283	4.023809945	1.976630312	8.678001538	3.570771614	5.327315925	3.570771614	5.327315925	0.670275925864111	0.379400	0	1.49192289535211	0.379621	0	GO:1990665,AnxA2-p11 complex;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0019897,extrinsic component of plasma membrane	GO:0005509,calcium ion binding;GO:0048306,calcium-dependent protein binding;GO:0044325,ion channel binding;GO:0042803,protein homodimerization activity	GO:0001765,membrane raft assembly;GO:0051099,positive regulation of binding;GO:0051894,positive regulation of focal adhesion assembly;GO:0043547,positive regulation of GTPase activity;GO:0051496,positive regulation of stress fiber assembly;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0072659,protein localization to plasma membrane;GO:0042493,response to drug;GO:0006900,vesicle budding from membrane	hsa:6281,path:hsa05132,Salmonella infection
ATPG_HUMAN	P36542	ATP5F1C	ATP synthase subunit gamma, mitochondrial	5.984442886	10.25259758	4.854721518	3.994816001	8.118520233	4.4247687595	8.118520233	4.4247687595	1.83478971993045	0.248440	0	0.545021584292454	0.247920	0	GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0005753,mitochondrial proton-transporting ATP synthase complex;GO:0000275,mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1);GO:0005739,mitochondrion	GO:0046933,proton-transporting ATP synthase activity, rotational mechanism;GO:0003723,RNA binding	GO:0006754,ATP biosynthetic process;GO:0015986,ATP synthesis coupled proton transport;GO:0042407,cristae formation;GO:0042776,mitochondrial ATP synthesis coupled proton transport;GO:0006119,oxidative phosphorylation	hsa:509,path:hsa00190,Oxidative phosphorylation;hsa:509,path:hsa04714,Thermogenesis;hsa:509,path:hsa05010,Alzheimer disease;hsa:509,path:hsa05012,Parkinson disease;hsa:509,path:hsa05016,Huntington disease
EHD3_HUMAN	Q9NZN3	EHD3	EH domain-containing protein 3	0.63735925	1.020125421	1.104842712	3.426180076	0.8287423355	2.265511394	0.8287423355	2.265511394	0.365808063333889	0.108878	0	2.73367402261785	0.109186	0	GO:0020018,ciliary pocket membrane;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005769,early endosome;GO:0030139,endocytic vesicle;GO:0010008,endosome membrane;GO:0005925,focal adhesion;GO:0043231,intracellular membrane-bounded organelle;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0055038,recycling endosome membrane	GO:0005524,ATP binding;GO:0005509,calcium ion binding;GO:0005525,GTP binding;GO:0003676,nucleic acid binding	GO:0007596,blood coagulation;GO:0060271,cilium assembly;GO:0034498,early endosome to Golgi transport;GO:0032456,endocytic recycling;GO:0006897,endocytosis;GO:0016197,endosomal transport;GO:0090160,Golgi to lysosome transport;GO:1901387,positive regulation of voltage-gated calcium channel activity;GO:0051260,protein homooligomerization;GO:0072659,protein localization to plasma membrane;GO:0015031,protein transport;GO:0001881,receptor recycling;GO:1903779,regulation of cardiac conduction;GO:0086036,regulation of cardiac muscle cell membrane potential;GO:0055117,regulation of cardiac muscle contraction;GO:1903358,regulation of Golgi organization	hsa:30845,path:hsa04144,Endocytosis
KC1A_HUMAN	P48729	CSNK1A1	Casein kinase I isoform alpha	0.609840104	0.383162776	0.654554852	0.805193881	0.49650144	0.7298743665	0.49650144	0.7298743665	0.680256031433048	0.388025	0	1.47003474249742	0.388237	0	GO:0030877,beta-catenin destruction complex;GO:0005813,centrosome;GO:0036064,ciliary basal body;GO:0005929,cilium;GO:0000777,condensed chromosome kinetochore;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity	GO:1904885,beta-catenin destruction complex assembly;GO:1904886,beta-catenin destruction complex disassembly;GO:0007049,cell cycle;GO:0051301,cell division;GO:0007166,cell surface receptor signaling pathway;GO:0007030,Golgi organization;GO:0045104,intermediate filament cytoskeleton organization;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0018105,peptidyl-serine phosphorylation;GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0006468,protein phosphorylation;GO:1904424,regulation of GTP binding;GO:0007165,signal transduction;GO:0016055,Wnt signaling pathway	hsa:1452,path:hsa04310,Wnt signaling pathway;hsa:1452,path:hsa04340,Hedgehog signaling pathway;hsa:1452,path:hsa05225,Hepatocellular carcinoma;hsa:1452,path:hsa05226,Gastric cancer;hsa:1452,path:hsa05224,Breast cancer;hsa:1452,path:hsa05165,Human papillomavirus infection
NIBA1_HUMAN	Q9BZQ8	NIBAN1	Protein Niban 1	0.348924782	0.941217016	1.096106216	1.455366554	0.645070899	1.275736385	0.645070899	1.275736385	0.505645920728364	0.230322	0	1.97766848105792	0.230648	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005886,plasma membrane		GO:0001933,negative regulation of protein phosphorylation;GO:0001934,positive regulation of protein phosphorylation;GO:0045727,positive regulation of translation;GO:0034976,response to endoplasmic reticulum stress	
MCCA_HUMAN	Q96RQ3	MCCC1	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	0.220048536	0.460137193	2.677726418	0.751082987	0.3400928645	1.7144047025	0.3400928645	1.7144047025	0.198373735212033	0.015090	-1	5.04098992203349	0.015194	1	GO:0002169,3-methylcrotonyl-CoA carboxylase complex, mitochondrial;GO:0005829,cytosol;GO:1905202,methylcrotonoyl-CoA carboxylase complex;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0009374,biotin binding;GO:0004075,biotin carboxylase activity;GO:0016421,CoA carboxylase activity;GO:0046872,metal ion binding;GO:0004485,methylcrotonoyl-CoA carboxylase activity;GO:0016874,ligase activity	GO:0006768,biotin metabolic process;GO:0009083,branched-chain amino acid catabolic process;GO:0006552,leucine catabolic process	hsa:56922,path:hsa00280,Valine, leucine and isoleucine degradation
DLRB1_HUMAN	Q9NP97	DYNLRB1	Dynein light chain roadblock-type 1	0.206538722	0.134755302	0.253238248	0.15014057	0.170647012	0.201689409	0.170647012	0.201689409	0.846088115613448	0.489238	0	1.18190999441584	0.489164	0	GO:0005813,centrosome;GO:0097542,ciliary tip;GO:0005929,cilium;GO:0005737,cytoplasm;GO:0005868,cytoplasmic dynein complex;GO:0016020,membrane;GO:0005874,microtubule	GO:0045505,dynein intermediate chain binding;GO:0003777,microtubule motor activity	GO:0035735,intraciliary transport involved in cilium assembly;GO:0007018,microtubule-based movement;GO:0007632,visual behavior	hsa:83658,path:hsa05132,Salmonella infection
FPRP_HUMAN	Q9P2B2	PTGFRN	Prostaglandin F2 receptor negative regulator	2.44245267	4.095767572	2.494528352	5.147807556	3.269110121	3.821167954	3.269110121	3.821167954	0.855526415052731	0.485510	0	1.16887098096014	0.485427	0	GO:0009986,cell surface;GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane		GO:0034389,lipid droplet organization;GO:0014905,myoblast fusion involved in skeletal muscle regeneration	
PGRP1_HUMAN	O75594	PGLYRP1	Peptidoglycan recognition protein 1	0.169295052	0.983750599	0.08410148	0.010530772	0.5765228255	0.047316126	0.5765228255	0.047316126	12.1844891845119	0.011449	1	0.0820715571130496	0.011293	-1	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0097013,phagocytic vesicle lumen;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen	GO:0008745,N-acetylmuramoyl-L-alanine amidase activity;GO:0042834,peptidoglycan binding;GO:0016019,peptidoglycan immune receptor activity;GO:0008270,zinc ion binding	GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0019730,antimicrobial humoral response;GO:0050830,defense response to Gram-positive bacterium;GO:0016045,detection of bacterium;GO:0045087,innate immune response;GO:0031640,killing of cells of other organism;GO:0043312,neutrophil degranulation;GO:0009253,peptidoglycan catabolic process	
KLKB1_HUMAN	P03952	KLKB1	Plasma kallikrein	0.090551888	0.364105363	0.135344535	0.699367108	0.2273286255	0.4173558215	0.2273286255	0.4173558215	0.544687803042901	0.266273	0	1.83591406749609	0.266583	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane	GO:0004252,serine-type endopeptidase activity;GO:0020037,heme binding;GO:0005506,iron ion binding;GO:0004497,monooxygenase activity;GO:0016705,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0007597,blood coagulation, intrinsic pathway;GO:0022617,extracellular matrix disassembly;GO:0002542,Factor XII activation;GO:0042730,fibrinolysis;GO:2000267,negative regulation of blood coagulation, intrinsic pathway;GO:0031639,plasminogen activation;GO:0051919,positive regulation of fibrinolysis;GO:0006508,proteolysis;GO:0031638,zymogen activation;GO:0007596,blood coagulation	hsa:3818,path:hsa04610,Complement and coagulation cascades
RS26_HUMAN	P62854	RPS26	40S ribosomal protein S26	1.851023808	3.79669915	0.258982923	0.007483087	2.823861479	0.133233005	2.823861479	0.133233005	21.1949094670649	0.003056	1	0.04718114043157	0.002998	-1	GO:0098556,cytoplasmic side of rough endoplasmic reticulum membrane;GO:0005829,cytosol;GO:0022627,cytosolic small ribosomal subunit;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0042788,polysomal ribosome;GO:0015935,small ribosomal subunit	GO:0045296,cadherin binding;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0033119,negative regulation of RNA splicing;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6231,path:hsa03010,Ribosome
RBP56_HUMAN	Q92804	TAF15	TATA-binding protein-associated factor 2N	2.55E-05	2.55E-05	0.105768301	0.171836427	2.55e-005	0.138802364	2.55e-005	0.138802364	0.000183714450281265	0.000000	-1	5443.22996078431	0.000000	1	GO:0005737,cytoplasm;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0046872,metal ion binding;GO:0003723,RNA binding;GO:0003712,transcription coregulator activity	GO:0048255,mRNA stabilization;GO:0045893,positive regulation of transcription, DNA-templated;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0006366,transcription by RNA polymerase II;GO:0006367,transcription initiation from RNA polymerase II promoter;GO:0006355,regulation of transcription, DNA-templated	hsa:8148,path:hsa03022,Basal transcription factors;hsa:8148,path:hsa05202,Transcriptional misregulation in cancer
AT2A3_HUMAN	Q93084	ATP2A3	Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0.828824009	0.236264915	1.011663665	1.090651049	0.532544462	1.051157357	0.532544462	1.051157357	0.506626775195562	0.231222	0	1.97383961716984	0.231549	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0031965,nuclear membrane;GO:0031090,organelle membrane;GO:0031095,platelet dense tubular network membrane;GO:0016529,sarcoplasmic reticulum;GO:0033017,sarcoplasmic reticulum membrane	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0015085,calcium ion transmembrane transporter activity;GO:0030899,calcium-dependent ATPase activity;GO:0008656,cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0044325,ion channel binding;GO:0046872,metal ion binding;GO:0005388,P-type calcium transporter activity;GO:0008553,P-type proton-exporting transporter activity	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0070588,calcium ion transmembrane transport;GO:0006816,calcium ion transport;GO:1903515,calcium ion transport from cytosol to endoplasmic reticulum;GO:0006874,cellular calcium ion homeostasis;GO:0070059,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0034220,ion transmembrane transport;GO:1900121,negative regulation of receptor binding;GO:1903779,regulation of cardiac conduction;GO:0150104,transport across blood-brain barrier	hsa:489,path:hsa04020,Calcium signaling pathway;hsa:489,path:hsa04024,cAMP signaling pathway;hsa:489,path:hsa04022,cGMP-PKG signaling pathway;hsa:489,path:hsa04919,Thyroid hormone signaling pathway;hsa:489,path:hsa04260,Cardiac muscle contraction;hsa:489,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:489,path:hsa04972,Pancreatic secretion;hsa:489,path:hsa05010,Alzheimer disease;hsa:489,path:hsa05017,Spinocerebellar ataxia;hsa:489,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:489,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:489,path:hsa05414,Dilated cardiomyopathy (DCM)
GRB2_HUMAN	P62993	GRB2	Growth factor receptor-bound protein 2	0.937596673	3.822212006	3.075012872	2.873120757	2.3799043395	2.9740668145	2.3799043395	2.9740668145	0.800218854498099	0.485536	0	1.24965813337053	0.485643	0	GO:0005911,cell-cell junction;GO:0008180,COP9 signalosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0070436,Grb2-EGFR complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0012506,vesicle membrane	GO:0046875,ephrin receptor binding;GO:0005154,epidermal growth factor receptor binding;GO:0042802,identical protein binding;GO:0043560,insulin receptor substrate binding;GO:0005168,neurotrophin TRKA receptor binding;GO:0001784,phosphotyrosine residue binding;GO:0019901,protein kinase binding;GO:0019903,protein phosphatase binding;GO:0044877,protein-containing complex binding;GO:0030674,protein-macromolecule adaptor activity;GO:0003723,RNA binding;GO:0017124,SH3 domain binding	GO:0031532,actin cytoskeleton reorganization;GO:0007568,aging;GO:0048646,anatomical structure formation involved in morphogenesis;GO:0007411,axon guidance;GO:0060670,branching involved in labyrinthine layer morphogenesis;GO:0071479,cellular response to ionizing radiation;GO:0019221,cytokine-mediated signaling pathway;GO:0035635,entry of bacterium into host cell;GO:0007173,epidermal growth factor receptor signaling pathway;GO:0038128,ERBB2 signaling pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0008286,insulin receptor signaling pathway;GO:0035723,interleukin-15-mediated signaling pathway;GO:0050900,leukocyte migration;GO:0000165,MAPK cascade;GO:0061024,membrane organization;GO:0042059,negative regulation of epidermal growth factor receptor signaling pathway;GO:0048011,neurotrophin TRK receptor signaling pathway;GO:0030838,positive regulation of actin filament polymerization;GO:0051897,positive regulation of protein kinase B signaling;GO:0046579,positive regulation of Ras protein signal transduction;GO:2000379,positive regulation of reactive oxygen species metabolic process;GO:0007265,Ras protein signal transduction;GO:0031623,receptor internalization;GO:0043408,regulation of MAPK cascade;GO:0042770,signal transduction in response to DNA damage;GO:0031295,T cell costimulation;GO:0016032,viral process	hsa:2885,path:hsa04014,Ras signaling pathway;hsa:2885,path:hsa04010,MAPK signaling pathway;hsa:2885,path:hsa04012,ErbB signaling pathway;hsa:2885,path:hsa04630,Jak-STAT signaling pathway;hsa:2885,path:hsa04068,FoxO signaling pathway;hsa:2885,path:hsa04072,Phospholipase D signaling pathway;hsa:2885,path:hsa04151,PI3K-Akt signaling pathway;hsa:2885,path:hsa04150,mTOR signaling pathway;hsa:2885,path:hsa04510,Focal adhesion;hsa:2885,path:hsa04540,Gap junction;hsa:2885,path:hsa04550,Signaling pathways regulating pluripotency of stem cells;hsa:2885,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:2885,path:hsa04660,T cell receptor signaling pathway;hsa:2885,path:hsa04662,B cell receptor signaling pathway;hsa:2885,path:hsa04664,Fc epsilon RI signaling pathway;hsa:2885,path:hsa04062,Chemokine signaling pathway;hsa:2885,path:hsa04910,Insulin signaling pathway;hsa:2885,path:hsa04912,GnRH signaling pathway;hsa:2885,path:hsa04915,Estrogen signaling pathway;hsa:2885,path:hsa04917,Prolactin signaling pathway;hsa:2885,path:hsa04926,Relaxin signaling pathway;hsa:2885,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:2885,path:hsa04722,Neurotrophin signaling pathway;hsa:2885,path:hsa04380,Osteoclast differentiation;hsa:2885,path:hsa04714,Thermogenesis;hsa:2885,path:hsa05200,Pathways in cancer;hsa:2885,path:hsa05206,MicroRNAs in cancer;hsa:2885,path:hsa05205,Proteoglycans in cancer;hsa:2885,path:hsa05203,Viral carcinogenesis;hsa:2885,path:hsa05231,Choline metabolism in cancer;hsa:2885,path:hsa05210,Colorectal cancer;hsa:2885,path:hsa05225,Hepatocellular carcinoma;hsa:2885,path:hsa05226,Gastric cancer;hsa:2885,path:hsa05214,Glioma;hsa:2885,path:hsa05221,Acute myeloid leukemia;hsa:2885,path:hsa05220,Chronic myeloid leukemia;hsa:2885,path:hsa05211,Renal cell carcinoma;hsa:2885,path:hsa05215,Prostate cancer;hsa:2885,path:hsa05213,Endometrial cancer;hsa:2885,path:hsa05224,Breast cancer;hsa:2885,path:hsa05223,Non-small cell lung cancer;hsa:2885,path:hsa05034,Alcoholism;hsa:2885,path:hsa05161,Hepatitis B;hsa:2885,path:hsa05160,Hepatitis C;hsa:2885,path:hsa05163,Human cytomegalovirus infection;hsa:2885,path:hsa05165,Human papillomavirus infection;hsa:2885,path:hsa01521,EGFR tyrosine kinase inhibitor resistance;hsa:2885,path:hsa01522,Endocrine resistance
ICAM1_HUMAN	P05362	ICAM1	Intercellular adhesion molecule 1	1.254865775	0.39943037	2.11006071	2.887540544	0.8271480725	2.498800627	0.8271480725	2.498800627	0.331018034637303	0.082990	0	3.02098343703751	0.083268	0	GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0001772,immunological synapse;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0045121,membrane raft;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0005178,integrin binding;GO:0038023,signaling receptor activity;GO:0004888,transmembrane signaling receptor activity;GO:0001618,virus receptor activity	GO:0002438,acute inflammatory response to antigenic stimulus;GO:0044406,adhesion of symbiont to host;GO:0007155,cell adhesion;GO:0033627,cell adhesion mediated by integrin;GO:0007569,cell aging;GO:0071312,cellular response to alkaloid;GO:1904646,cellular response to amyloid-beta;GO:0071549,cellular response to dexamethasone stimulus;GO:0071333,cellular response to glucose stimulus;GO:0071456,cellular response to hypoxia;GO:0071347,cellular response to interleukin-1;GO:0071354,cellular response to interleukin-6;GO:1990830,cellular response to leukemia inhibitory factor;GO:0071222,cellular response to lipopolysaccharide;GO:0031669,cellular response to nutrient levels;GO:0071356,cellular response to tumor necrosis factor;GO:0019221,cytokine-mediated signaling pathway;GO:0061028,establishment of endothelial barrier;GO:0090557,establishment of endothelial intestinal barrier;GO:0097368,establishment of Sertoli cell barrier;GO:0030198,extracellular matrix organization;GO:0007157,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0007159,leukocyte cell-cell adhesion;GO:0050900,leukocyte migration;GO:0022614,membrane to membrane docking;GO:0051926,negative regulation of calcium ion transport;GO:2000352,negative regulation of endothelial cell apoptotic process;GO:1902042,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0001541,ovarian follicle development;GO:0030838,positive regulation of actin filament polymerization;GO:0002693,positive regulation of cellular extravasation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0043547,positive regulation of GTPase activity;GO:1904996,positive regulation of leukocyte adhesion to vascular endothelial cell;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0045429,positive regulation of nitric oxide biosynthetic process;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0045907,positive regulation of vasoconstriction;GO:0046813,receptor-mediated virion attachment to host cell;GO:0008360,regulation of cell shape;GO:0050776,regulation of immune response;GO:0001910,regulation of leukocyte mediated cytotoxicity;GO:1900027,regulation of ruffle assembly;GO:0043200,response to amino acid;GO:0001975,response to amphetamine;GO:0046688,response to copper ion;GO:0042493,response to drug;GO:0045471,response to ethanol;GO:0034698,response to gonadotropin;GO:0032868,response to insulin;GO:0010212,response to ionizing radiation;GO:0010477,response to sulfur dioxide;GO:0007605,sensory perception of sound;GO:0002291,T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0002457,T cell antigen processing and presentation;GO:0072683,T cell extravasation;GO:0098609,cell-cell adhesion	hsa:3383,path:hsa04064,NF-kappa B signaling pathway;hsa:3383,path:hsa04668,TNF signaling pathway;hsa:3383,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3383,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3383,path:hsa04670,Leukocyte transendothelial migration;hsa:3383,path:hsa05323,Rheumatoid arthritis;hsa:3383,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:3383,path:hsa05416,Viral myocarditis;hsa:3383,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:3383,path:hsa05150,Staphylococcus aureus infection;hsa:3383,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3383,path:hsa05164,Influenza A;hsa:3383,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3383,path:hsa05169,Epstein-Barr virus infection;hsa:3383,path:hsa05144,Malaria;hsa:3383,path:hsa05143,African trypanosomiasis
ACSF2_HUMAN	Q96CM8	ACSF2	Medium-chain acyl-CoA ligase ACSF2, mitochondrial	0.066381558	0.619119569	0.63345116	0.168223582	0.3427505635	0.400837371	0.3427505635	0.400837371	0.855086347475321	0.485683	0	1.16947253684092	0.485601	0	GO:0005759,mitochondrial matrix	GO:0005524,ATP binding;GO:0047760,butyrate-CoA ligase activity;GO:0031956,medium-chain fatty acid-CoA ligase activity	GO:0006637,acyl-CoA metabolic process;GO:0006631,fatty acid metabolic process	
ANR44_HUMAN	Q8N8A2	ANKRD44	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B	0.16541097	0.209342051	0.219197257	0.202850027	0.1873765105	0.211023642	0.1873765105	0.211023642	0.88794084266634	0.473023	0	1.12620115209158	0.472912	0				
IMA7_HUMAN	O60684	KPNA6	Importin subunit alpha-7	0.401691863	1.325057031	3.460440157	8.591142667	0.863374447	6.025791412	0.863374447	6.025791412	0.143279842923312	0.003850	-1	6.97934880159825	0.003888	1	GO:0005737,cytoplasm;GO:0043657,host cell;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0061608,nuclear import signal receptor activity;GO:0008139,nuclear localization sequence binding	GO:0075506,entry of viral genome into host nucleus through nuclear pore complex via importin;GO:0060135,maternal process involved in female pregnancy;GO:0030682,mitigation of host defenses by symbiont;GO:0006607,NLS-bearing protein import into nucleus;GO:1900017,positive regulation of cytokine production involved in inflammatory response;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:1903902,positive regulation of viral life cycle;GO:0019079,viral genome replication;GO:0006606,protein import into nucleus	hsa:23633,path:hsa05164,Influenza A
NUCL_HUMAN	P19338	NCL	Nucleolin	21.41555433	21.19106534	24.71289565	21.66580164	21.303309835	23.189348645	21.303309835	23.189348645	0.918667883308285	0.461622	0	1.08853266579738	0.461487	0	GO:0005938,cell cortex;GO:0005694,chromosome;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0005681,spliceosomal complex	GO:0044547,DNA topoisomerase binding;GO:0042802,identical protein binding;GO:0048027,mRNA 5'-UTR binding;GO:0008022,protein C-terminus binding;GO:0003723,RNA binding;GO:0042162,telomeric DNA binding;GO:0003677,DNA binding	GO:0001525,angiogenesis;GO:0017148,negative regulation of translation;GO:0048026,positive regulation of mRNA splicing, via spliceosome;GO:1901838,positive regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0071364,cellular response to epidermal growth factor stimulus;GO:1990830,cellular response to leukemia inhibitory factor;GO:0045944,positive regulation of transcription by RNA polymerase II	hsa:4691,path:hsa05130,Pathogenic Escherichia coli infection
PALD_HUMAN	Q9ULE6	PALD1	Paladin	0.008332126	0.030487768	0.019615883	0.021999917	0.019409947	0.0208079	0.019409947	0.0208079	0.932816238063428	0.456510	0	1.07202250474976	0.456363	0	GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0004725,protein tyrosine phosphatase activity		
NB5R1_HUMAN	Q9UHQ9	CYB5R1	NADH-cytochrome b5 reductase 1	2.606333885	5.831219273	3.20793487	2.402779701	4.218776579	2.8053572855	4.218776579	2.8053572855	1.50382862133302	0.304413	0	0.664969389340113	0.303970	0	GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005886,plasma membrane;GO:0031092,platelet alpha granule membrane	GO:0004128,cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0071949,FAD binding	GO:0015701,bicarbonate transport;GO:0002576,platelet degranulation;GO:0016126,sterol biosynthetic process	hsa:51706,path:hsa00520,Amino sugar and nucleotide sugar metabolism
SFTA1_HUMAN	Q8IWL2	SFTPA1	Pulmonary surfactant-associated protein A1	0.654872575	0.959521133	8.946119447	19.62972297	0.807196854	14.2879212085	0.807196854	14.2879212085	0.0564950521647468	0.000022	-1	17.7006651322999	0.000022	1	GO:0045334,clathrin-coated endocytic vesicle;GO:0005581,collagen trimer;GO:0005789,endoplasmic reticulum membrane;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0042599,lamellar body;GO:0005771,multivesicular body;GO:0005791,rough endoplasmic reticulum	GO:0030246,carbohydrate binding;GO:0005319,lipid transporter activity	GO:0044267,cellular protein metabolic process;GO:0008228,opsonization;GO:0007585,respiratory gaseous exchange by respiratory system;GO:0002224,toll-like receptor signaling pathway	hsa:653509,path:hsa04145,Phagosome;hsa:653509,path:hsa05133,Pertussis
GALK1_HUMAN	P51570	GALK1	Galactokinase	1.260922563	0.572277085	1.572297266	1.174912809	0.916599824	1.3736050375	0.916599824	1.3736050375	0.667295036765618	0.376811	0	1.49858749863779	0.377034	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane	GO:0005524,ATP binding;GO:0004335,galactokinase activity;GO:0005534,galactose binding	GO:0019402,galactitol metabolic process;GO:0019388,galactose catabolic process;GO:0006012,galactose metabolic process;GO:0061623,glycolytic process from galactose	
CYB5_HUMAN	P00167	CYB5A	Cytochrome b5	0.569805547	2.78032565	0.944032619	2.735687282	1.6750655985	1.8398599505	1.6750655985	1.8398599505	0.910431034734347	0.464638	0	1.09838083484466	0.464509	0	GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane	GO:0004129,cytochrome-c oxidase activity;GO:0009055,electron transfer activity;GO:0019899,enzyme binding;GO:0020037,heme binding;GO:0046872,metal ion binding	GO:0019852,L-ascorbic acid metabolic process;GO:0045048,protein insertion into ER membrane;GO:0046686,response to cadmium ion	
AK1C3_HUMAN	P42330	AKR1C3	Aldo-keto reductase family 1 member C3	2.794233335	51.02706748	11.30282529	4.765565181	26.9106504075	8.0341952355	26.9106504075	8.0341952355	3.34951412290708	0.117670	0	0.298550763873803	0.117123	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0047020,15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity;GO:0044594,17-beta-hydroxysteroid dehydrogenase (NAD+) activity;GO:0072582,17-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:0047024,5alpha-androstane-3beta,17beta-diol dehydrogenase activity;GO:0004032,alditol;GO:0004033,aldo-keto reductase (NADP) activity;GO:0047044,androstan-3-alpha,17-beta-diol dehydrogenase activity;GO:0047023,androsterone dehydrogenase activity;GO:0032052,bile acid binding;GO:0047834,D-threo-aldose 1-dehydrogenase activity;GO:0047787,delta4-3-oxosteroid 5beta-reductase activity;GO:0035410,dihydrotestosterone 17-beta-dehydrogenase activity;GO:0045550,geranylgeranyl reductase activity;GO:0045703,ketoreductase activity;GO:0047086,ketosteroid monooxygenase activity;GO:0016655,oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0018636,phenanthrene 9,10-monooxygenase activity;GO:0036131,prostaglandin D2 11-ketoreductase activity;GO:0036130,prostaglandin H2 endoperoxidase reductase activity;GO:0047017,prostaglandin-F synthase activity;GO:0001758,retinal dehydrogenase activity;GO:0004745,retinol dehydrogenase activity;GO:0016229,steroid dehydrogenase activity;GO:0047045,testosterone 17-beta-dehydrogenase (NADP+) activity;GO:0047035,testosterone dehydrogenase (NAD+) activity;GO:0004303,estradiol 17-beta-dehydrogenase activity	GO:0071276,cellular response to cadmium ion;GO:0071277,cellular response to calcium ion;GO:0071384,cellular response to corticosteroid stimulus;GO:0071395,cellular response to jasmonic acid stimulus;GO:0071799,cellular response to prostaglandin D stimulus;GO:0071379,cellular response to prostaglandin stimulus;GO:0034614,cellular response to reactive oxygen species;GO:0009267,cellular response to starvation;GO:0019371,cyclooxygenase pathway;GO:0044597,daunorubicin metabolic process;GO:0044598,doxorubicin metabolic process;GO:0016488,farnesol catabolic process;GO:0007186,G protein-coupled receptor signaling pathway;GO:0030216,keratinocyte differentiation;GO:0043170,macromolecule metabolic process;GO:0008584,male gonad development;GO:1900053,negative regulation of retinoic acid biosynthetic process;GO:0010942,positive regulation of cell death;GO:0008284,positive regulation of cell population proliferation;GO:2000353,positive regulation of endothelial cell apoptotic process;GO:0051897,positive regulation of protein kinase B signaling;GO:2000379,positive regulation of reactive oxygen species metabolic process;GO:0042448,progesterone metabolic process;GO:0006693,prostaglandin metabolic process;GO:0048385,regulation of retinoic acid receptor signaling pathway;GO:2000224,regulation of testosterone biosynthetic process;GO:0070293,renal absorption;GO:0007584,response to nutrient;GO:0042574,retinal metabolic process;GO:0001523,retinoid metabolic process;GO:0008202,steroid metabolic process;GO:0061370,testosterone biosynthetic process	hsa:8644,path:hsa00140,Steroid hormone biosynthesis;hsa:8644,path:hsa00590,Arachidonic acid metabolism;hsa:8644,path:hsa00790,Folate biosynthesis;hsa:8644,path:hsa04913,Ovarian steroidogenesis
COMD3_HUMAN	Q9UBI1	COMMD3	COMM domain-containing protein 3	0.261267997	0.615446755	0.035609114	2.55E-05	0.438357376	0.017817307	0.438357376	0.017817307	24.6028973963349	0.002069	1	0.0406456192492584	0.002027	-1	GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005634,nucleus;GO:0005829,cytosol;GO:0016604,nuclear body	GO:0046872,metal ion binding	GO:0043312,neutrophil degranulation;GO:0006814,sodium ion transport	hsa:100532731,path:hsa04550,Signaling pathways regulating pluripotency of stem cells;hsa:100532731,path:hsa05202,Transcriptional misregulation in cancer;hsa:100532731,path:hsa05206,MicroRNAs in cancer
PESC_HUMAN	O00541	PES1	Pescadillo homolog	0.115958214	0.105278881	0.192373334	0.092919382	0.1106185475	0.142646358	0.1106185475	0.142646358	0.77547403979287	0.466423	0	1.28953381891043	0.466551	0	GO:0005694,chromosome;GO:0005829,cytosol;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0070545,PeBoW complex;GO:0030687,preribosome, large subunit precursor	GO:0043021,ribonucleoprotein complex binding;GO:0003723,RNA binding	GO:0008283,cell population proliferation;GO:0000466,maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000463,maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0051726,regulation of cell cycle;GO:0042273,ribosomal large subunit biogenesis;GO:0006364,rRNA processing;GO:0042254,ribosome biogenesis	
ITPR1_HUMAN	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.027056045	0.019842536	0.07961591	0.077683762	0.0234492905	0.078649836	0.0234492905	0.078649836	0.298147989780932	0.061165	0	3.35403904864414	0.061408	0	GO:0005955,calcineurin complex;GO:0030659,cytoplasmic vesicle membrane;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005637,nuclear inner membrane;GO:0005730,nucleolus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0031088,platelet dense granule membrane;GO:0031094,platelet dense tubular network;GO:0031095,platelet dense tubular network membrane;GO:0014069,postsynaptic density;GO:0016529,sarcoplasmic reticulum;GO:0098685,Schaffer collateral - CA1 synapse;GO:0030667,secretory granule membrane;GO:0030658,transport vesicle membrane	GO:0019855,calcium channel inhibitor activity;GO:0005509,calcium ion binding;GO:0015085,calcium ion transmembrane transporter activity;GO:0015278,calcium-release channel activity;GO:0070679,inositol 1,4,5 trisphosphate binding;GO:0098695,inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels;GO:0005220,inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0035091,phosphatidylinositol binding;GO:0005262,calcium channel activity;GO:0005216,ion channel activity	GO:0006816,calcium ion transport;GO:0032469,endoplasmic reticulum calcium ion homeostasis;GO:0042045,epithelial fluid transport;GO:0070059,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0050849,negative regulation of calcium-mediated signaling;GO:0030168,platelet activation;GO:0009791,post-embryonic development;GO:0010506,regulation of autophagy;GO:1903779,regulation of cardiac conduction;GO:0050796,regulation of insulin secretion;GO:0051209,release of sequestered calcium ion into cytosol;GO:0001666,response to hypoxia;GO:0007165,signal transduction;GO:0050882,voluntary musculoskeletal movement	hsa:3708,path:hsa04371,Apelin signaling pathway;hsa:3708,path:hsa04020,Calcium signaling pathway;hsa:3708,path:hsa04070,Phosphatidylinositol signaling system;hsa:3708,path:hsa04022,cGMP-PKG signaling pathway;hsa:3708,path:hsa04140,Autophagy - animal;hsa:3708,path:hsa04114,Oocyte meiosis;hsa:3708,path:hsa04210,Apoptosis;hsa:3708,path:hsa04218,Cellular senescence;hsa:3708,path:hsa04540,Gap junction;hsa:3708,path:hsa04611,Platelet activation;hsa:3708,path:hsa04621,NOD-like receptor signaling pathway;hsa:3708,path:hsa04625,C-type lectin receptor signaling pathway;hsa:3708,path:hsa04922,Glucagon signaling pathway;hsa:3708,path:hsa04929,GnRH secretion;hsa:3708,path:hsa04912,GnRH signaling pathway;hsa:3708,path:hsa04915,Estrogen signaling pathway;hsa:3708,path:hsa04921,Oxytocin signaling pathway;hsa:3708,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:3708,path:hsa04918,Thyroid hormone synthesis;hsa:3708,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:3708,path:hsa04924,Renin secretion;hsa:3708,path:hsa04925,Aldosterone synthesis and secretion;hsa:3708,path:hsa04927,Cortisol synthesis and secretion;hsa:3708,path:hsa04270,Vascular smooth muscle contraction;hsa:3708,path:hsa04970,Salivary secretion;hsa:3708,path:hsa04971,Gastric acid secretion;hsa:3708,path:hsa04972,Pancreatic secretion;hsa:3708,path:hsa04724,Glutamatergic synapse;hsa:3708,path:hsa04725,Cholinergic synapse;hsa:3708,path:hsa04728,Dopaminergic synapse;hsa:3708,path:hsa04726,Serotonergic synapse;hsa:3708,path:hsa04720,Long-term potentiation;hsa:3708,path:hsa04730,Long-term depression;hsa:3708,path:hsa04723,Retrograde endocannabinoid signaling;hsa:3708,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:3708,path:hsa04713,Circadian entrainment;hsa:3708,path:hsa05205,Proteoglycans in cancer;hsa:3708,path:hsa05010,Alzheimer disease;hsa:3708,path:hsa05016,Huntington disease;hsa:3708,path:hsa05017,Spinocerebellar ataxia;hsa:3708,path:hsa04934,Cushing syndrome;hsa:3708,path:hsa05131,Shigellosis;hsa:3708,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3708,path:hsa05163,Human cytomegalovirus infection;hsa:3708,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection
MYO1F_HUMAN	O00160	MYO1F	Unconventional myosin-If	2.02980222	1.8159874	2.134120443	2.313328751	1.92289481	2.223724597	1.92289481	2.223724597	0.864718055731431	0.481919	0	1.1564463045173	0.481829	0	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005902,microvillus;GO:0005886,plasma membrane;GO:0016461,unconventional myosin complex;GO:0031982,vesicle;GO:0016459,myosin complex	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0030898,actin-dependent ATPase activity;GO:0005524,ATP binding;GO:0005516,calmodulin binding;GO:0000146,microfilament motor activity;GO:0003774,motor activity	GO:0007015,actin filament organization;GO:0030050,vesicle transport along actin filament	hsa:4542,path:hsa05130,Pathogenic Escherichia coli infection
EFTS_HUMAN	P43897	TSFM	Elongation factor Ts, mitochondrial	0.066244446	0.067485665	0.089163828	2.55E-05	0.0668650555	0.044594664	0.0668650555	0.044594664	1.4993958806372	0.305285	0	0.666935272341171	0.304842	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0003723,RNA binding;GO:0003746,translation elongation factor activity	GO:0070125,mitochondrial translational elongation;GO:0032784,regulation of DNA-templated transcription, elongation;GO:0070129,regulation of mitochondrial translation;GO:0006414,translational elongation	
HMGB1_HUMAN	P09429	HMGB1	High mobility group protein B1	21.07869327	19.44588033	5.579908988	1.467297148	20.2622868	3.523603068	20.2622868	3.523603068	5.75044532796961	0.050269	0	0.17389957524439	0.049877	-1	GO:0035868,alphav-beta3 integrin-HMGB1 complex;GO:0009986,cell surface;GO:0000793,condensed chromosome;GO:0005769,early endosome;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0043005,neuron projection;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0034774,secretory granule lumen;GO:0017053,transcription repressor complex;GO:0005694,chromosome	GO:0000405,bubble DNA binding;GO:0019958,C-X-C chemokine binding;GO:0010858,calcium-dependent protein kinase regulator activity;GO:0042056,chemoattractant activity;GO:0005125,cytokine activity;GO:0003684,damaged DNA binding;GO:0008301,DNA binding, bending;GO:0070182,DNA polymerase binding;GO:0003690,double-stranded DNA binding;GO:0003725,double-stranded RNA binding;GO:0000400,four-way junction DNA binding;GO:0005178,integrin binding;GO:0001530,lipopolysaccharide binding;GO:0016829,lyase activity;GO:0001786,phosphatidylserine binding;GO:0030295,protein kinase activator activity;GO:0050786,RAGE receptor binding;GO:0070491,repressing transcription factor binding;GO:0003723,RNA binding;GO:0003697,single-stranded DNA binding;GO:0003727,single-stranded RNA binding;GO:0097100,supercoiled DNA binding;GO:0003713,transcription coactivator activity;GO:0008134,transcription factor binding;GO:0000976,transcription regulatory region sequence-specific DNA binding;GO:0003677,DNA binding	GO:0002218,activation of innate immune response;GO:0043277,apoptotic cell clearance;GO:0006309,apoptotic DNA fragmentation;GO:0006914,autophagy;GO:0006284,base-excision repair;GO:0098761,cellular response to interleukin-7;GO:0071222,cellular response to lipopolysaccharide;GO:0031497,chromatin assembly;GO:0006342,chromatin silencing;GO:0002407,dendritic cell chemotaxis;GO:0032392,DNA geometric change;GO:0006310,DNA recombination;GO:0006265,DNA topological change;GO:0006303,double-strand break repair via nonhomologous end joining;GO:0035767,endothelial cell chemotaxis;GO:0001935,endothelial cell proliferation;GO:0001654,eye development;GO:0006954,inflammatory response;GO:0002437,inflammatory response to antigenic stimulus;GO:0045087,innate immune response;GO:0030324,lung development;GO:0002281,macrophage activation involved in immune response;GO:0001773,myeloid dendritic cell activation;GO:2000426,negative regulation of apoptotic cell clearance;GO:0043537,negative regulation of blood vessel endothelial cell migration;GO:0043371,negative regulation of CD4-positive, alpha-beta T cell differentiation;GO:0032689,negative regulation of interferon-gamma production;GO:0017055,negative regulation of RNA polymerase II transcription preinitiation complex assembly;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0031175,neuron projection development;GO:0097350,neutrophil clearance;GO:0043312,neutrophil degranulation;GO:0002270,plasmacytoid dendritic cell activation;GO:0042104,positive regulation of activated T cell proliferation;GO:0043065,positive regulation of apoptotic process;GO:0010508,positive regulation of autophagy;GO:0043536,positive regulation of blood vessel endothelial cell migration;GO:2000343,positive regulation of chemokine (C-X-C motif) ligand 2 production;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007204,positive regulation of cytosolic calcium ion concentration;GO:2001200,positive regulation of dendritic cell differentiation;GO:0043388,positive regulation of DNA binding;GO:0051106,positive regulation of DNA ligation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0045819,positive regulation of glycogen catabolic process;GO:0032727,positive regulation of interferon-alpha production;GO:0032728,positive regulation of interferon-beta production;GO:0032731,positive regulation of interleukin-1 beta production;GO:0032732,positive regulation of interleukin-1 production;GO:0032733,positive regulation of interleukin-10 production;GO:0032735,positive regulation of interleukin-12 production;GO:0032755,positive regulation of interleukin-6 production;GO:0032757,positive regulation of interleukin-8 production;GO:0046330,positive regulation of JNK cascade;GO:0043410,positive regulation of MAPK cascade;GO:0032425,positive regulation of mismatch repair;GO:0071639,positive regulation of monocyte chemotactic protein-1 production;GO:0090026,positive regulation of monocyte chemotaxis;GO:0045639,positive regulation of myeloid cell differentiation;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:1903672,positive regulation of sprouting angiogenesis;GO:0034137,positive regulation of toll-like receptor 2 signaling pathway;GO:0034145,positive regulation of toll-like receptor 4 signaling pathway;GO:0034165,positive regulation of toll-like receptor 9 signaling pathway;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0032760,positive regulation of tumor necrosis factor production;GO:1905564,positive regulation of vascular endothelial cell proliferation;GO:0090303,positive regulation of wound healing;GO:2000819,regulation of nucleotide-excision repair;GO:0032072,regulation of restriction endodeoxyribonuclease activity;GO:0002840,regulation of T cell mediated immune response to tumor cell;GO:0002643,regulation of tolerance induction;GO:0006357,regulation of transcription by RNA polymerase II;GO:0051384,response to glucocorticoid;GO:0035711,T-helper 1 cell activation;GO:0045063,T-helper 1 cell differentiation;GO:0002224,toll-like receptor signaling pathway;GO:0033151,V(D)J recombination;GO:0016032,viral process	hsa:3146,path:hsa03410,Base excision repair;hsa:3146,path:hsa04140,Autophagy - animal;hsa:3146,path:hsa04217,Necroptosis
PSD13_HUMAN	Q9UNM6	PSMD13	26S proteasome non-ATPase regulatory subunit 13	3.845804479	2.925914272	4.756614031	3.59230517	3.3858593755	4.1744596005	3.3858593755	4.1744596005	0.811089266523134	0.493760	0	1.23290991666881	0.493857	0	GO:0005829,cytosol;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0022624,proteasome accessory complex;GO:0000502,proteasome complex;GO:0005838,proteasome regulatory particle;GO:0008541,proteasome regulatory particle, lid subcomplex;GO:0034774,secretory granule lumen	GO:0005198,structural molecule activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0007127,meiosis I;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0043312,neutrophil degranulation;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043248,proteasome assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5719,path:hsa03050,Proteasome;hsa:5719,path:hsa05169,Epstein-Barr virus infection
EIF3G_HUMAN	O75821	EIF3G	Eukaryotic translation initiation factor 3 subunit G	0.586158624	0.292151235	0.933176122	0.236081585	0.4391549295	0.5846288535	0.4391549295	0.5846288535	0.75116875753037	0.447124	0	1.3312587750424	0.447274	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016282,eukaryotic 43S preinitiation complex;GO:0033290,eukaryotic 48S preinitiation complex;GO:0005852,eukaryotic translation initiation factor 3 complex;GO:0048471,perinuclear region of cytoplasm	GO:0003723,RNA binding;GO:0003743,translation initiation factor activity	GO:0001732,formation of cytoplasmic translation initiation complex;GO:0006413,translational initiation;GO:0075525,viral translational termination-reinitiation	hsa:8666,path:hsa03013,RNA transport
ANM5_HUMAN	O14744	PRMT5	Protein arginine N-methyltransferase 5	1.697245471	0.797013091	1.464469396	1.796120854	1.247129281	1.630295125	1.247129281	1.630295125	0.764971483920741	0.458147	0	1.30723827099365	0.458285	0	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0035097,histone methyltransferase complex;GO:0034709,methylosome;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0070888,E-box binding;GO:0044020,histone methyltransferase activity (H4-R3 specific);GO:0008469,histone-arginine N-methyltransferase activity;GO:0042802,identical protein binding;GO:0008327,methyl-CpG binding;GO:0008168,methyltransferase activity;GO:0002039,p53 binding;GO:0046982,protein heterodimerization activity;GO:0016274,protein-arginine N-methyltransferase activity;GO:0035243,protein-arginine omega-N symmetric methyltransferase activity;GO:0043021,ribonucleoprotein complex binding;GO:0003714,transcription corepressor activity	GO:0032922,circadian regulation of gene expression;GO:0006353,DNA-templated transcription, termination;GO:0042118,endothelial cell activation;GO:0090161,Golgi ribbon formation;GO:0034969,histone arginine methylation;GO:0043985,histone H4-R3 methylation;GO:0097421,liver regeneration;GO:0045596,negative regulation of cell differentiation;GO:0018216,peptidyl-arginine methylation;GO:0035246,peptidyl-arginine N-methylation;GO:1904992,positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway;GO:0048714,positive regulation of oligodendrocyte differentiation;GO:0044030,regulation of DNA methylation;GO:0070372,regulation of ERK1 and ERK2 cascade;GO:0007088,regulation of mitotic nuclear division;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0006355,regulation of transcription, DNA-templated;GO:0000387,spliceosomal snRNP assembly	hsa:10419,path:hsa03013,RNA transport
LRC8C_HUMAN	Q8TDW0	LRRC8C	Volume-regulated anion channel subunit LRRC8C	0.021260555	0.057716722	0.073985935	0.052086213	0.0394886385	0.063036074	0.0394886385	0.063036074	0.626445081272035	0.340754	0	1.59630912572486	0.341010	0	GO:0005737,cytoplasm;GO:0005789,endoplasmic reticulum membrane;GO:0005887,integral component of plasma membrane;GO:0034702,ion channel complex;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0005225,volume-sensitive anion channel activity	GO:0098656,anion transmembrane transport;GO:0015810,aspartate transmembrane transport;GO:0071470,cellular response to osmotic stress;GO:0140361,cyclic-GMP-AMP transmembrane import across plasma membrane;GO:0034214,protein hexamerization;GO:0015734,taurine transport;GO:0055085,transmembrane transport	
CBR1_HUMAN	P16152	CBR1	Carbonyl reductase [NADPH] 1	6.899961298	16.92851401	17.74812396	11.21383086	11.914237654	14.48097741	11.914237654	14.48097741	0.822750931561601	0.498642	0	1.21543466149832	0.498589	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:1903561,extracellular vesicle	GO:0047021,15-hydroxyprostaglandin dehydrogenase (NADP+) activity;GO:0047020,15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity;GO:0004090,carbonyl reductase (NADPH) activity;GO:0016655,oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0050221,prostaglandin-E2 9-reductase activity;GO:0016491,oxidoreductase activity	GO:0019371,cyclooxygenase pathway;GO:0017144,drug metabolic process;GO:0030855,epithelial cell differentiation;GO:2000379,positive regulation of reactive oxygen species metabolic process;GO:0042373,vitamin K metabolic process	hsa:873,path:hsa00590,Arachidonic acid metabolism;hsa:873,path:hsa00790,Folate biosynthesis;hsa:873,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:873,path:hsa05204,Chemical carcinogenesis
ASCC3_HUMAN	Q8N3C0	ASCC3	Activating signal cointegrator 1 complex subunit 3	0.10014519	0.137754993	0.234686881	0.384417819	0.1189500915	0.30955235	0.1189500915	0.30955235	0.384264863439092	0.123577	0	2.60237168459849	0.123895	0	GO:0099053,activating signal cointegrator 1 complex;GO:0005829,cytosol;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0043138,3'-5' DNA helicase activity;GO:0005524,ATP binding;GO:0003723,RNA binding	GO:0008283,cell population proliferation;GO:0006307,DNA dealkylation involved in DNA repair;GO:0032508,DNA duplex unwinding	
GOGA3_HUMAN	Q08378	GOLGA3	Golgin subfamily A member 3	0.300621148	0.166445087	0.329580441	0.493389222	0.2335331175	0.4114848315	0.2335331175	0.4114848315	0.567537609220475	0.287288	0	1.76199776676214	0.287585	0	GO:0005829,cytosol;GO:0090498,extrinsic component of Golgi membrane;GO:0005794,Golgi apparatus;GO:0032580,Golgi cisterna membrane;GO:0000139,Golgi membrane;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm	GO:0045296,cadherin binding	GO:0007283,spermatogenesis	
HEXB_HUMAN	P07686	HEXB	Beta-hexosaminidase subunit beta	5.926573222	7.956889733	4.0949782	6.179841516	6.9417314775	5.137409858	6.9417314775	5.137409858	1.35121231697921	0.336676	0	0.740076143056198	0.336287	0	GO:0001669,acrosomal vesicle;GO:0042582,azurophil granule;GO:0035578,azurophil granule lumen;GO:0060473,cortical granule;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0043202,lysosomal lumen;GO:0016020,membrane;GO:0030133,transport vesicle	GO:0008375,acetylglucosaminyltransferase activity;GO:0004563,beta-N-acetylhexosaminidase activity;GO:0042802,identical protein binding;GO:0102148,N-acetyl-beta-D-galactosaminidase activity	GO:0043615,astrocyte cell migration;GO:0006874,cellular calcium ion homeostasis;GO:0044267,cellular protein metabolic process;GO:0030207,chondroitin sulfate catabolic process;GO:0006689,ganglioside catabolic process;GO:0006687,glycosphingolipid metabolic process;GO:0030214,hyaluronan catabolic process;GO:0042340,keratan sulfate catabolic process;GO:0019915,lipid storage;GO:0007626,locomotory behavior;GO:0007040,lysosome organization;GO:0008049,male courtship behavior;GO:0042552,myelination;GO:0050885,neuromuscular process controlling balance;GO:0043312,neutrophil degranulation;GO:0009313,oligosaccharide catabolic process;GO:0048477,oogenesis;GO:0007341,penetration of zona pellucida;GO:0008654,phospholipid biosynthetic process;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0008360,regulation of cell shape;GO:0007605,sensory perception of sound;GO:0007338,single fertilization;GO:0001501,skeletal system development;GO:0005975,carbohydrate metabolic process	hsa:3074,path:hsa00520,Amino sugar and nucleotide sugar metabolism;hsa:3074,path:hsa00513,Various types of N-glycan biosynthesis;hsa:3074,path:hsa00531,Glycosaminoglycan degradation;hsa:3074,path:hsa00603,Glycosphingolipid biosynthesis - globo and isoglobo series;hsa:3074,path:hsa00604,Glycosphingolipid biosynthesis - ganglio series;hsa:3074,path:hsa00511,Other glycan degradation;hsa:3074,path:hsa04142,Lysosome
SCOT1_HUMAN	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	1.050528504	0.286309436	1.03250705	1.176560704	0.66841897	1.104533877	0.66841897	1.104533877	0.605159320070361	0.321597	0	1.65245740557004	0.321870	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0008260,3-oxoacid CoA-transferase activity;GO:0008410,CoA-transferase activity;GO:0042802,identical protein binding	GO:0060612,adipose tissue development;GO:0007420,brain development;GO:0046950,cellular ketone body metabolic process;GO:0007507,heart development;GO:0046952,ketone body catabolic process;GO:0042182,ketone catabolic process;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0014823,response to activity;GO:0042493,response to drug;GO:0045471,response to ethanol;GO:0009725,response to hormone;GO:0007584,response to nutrient;GO:0042594,response to starvation	hsa:5019,path:hsa00650,Butanoate metabolism;hsa:5019,path:hsa00072,Synthesis and degradation of ketone bodies;hsa:5019,path:hsa00280,Valine, leucine and isoleucine degradation
PPAL_HUMAN	P11117	ACP2	Lysosomal acid phosphatase	0.857566156	1.37128959	3.434217996	3.005574783	1.114427873	3.2198963895	1.114427873	3.2198963895	0.346106749469989	0.093899	0	2.88928199617994	0.094191	0	GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0043202,lysosomal lumen;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0016020,membrane	GO:0003993,acid phosphatase activity;GO:0016791,phosphatase activity	GO:0016311,dephosphorylation;GO:0007040,lysosome organization	hsa:53,path:hsa00740,Riboflavin metabolism;hsa:53,path:hsa04142,Lysosome
TM9S3_HUMAN	Q9HD45	TM9SF3	Transmembrane 9 superfamily member 3	1.627417982	1.436804617	1.727219418	0.902994503	1.5321112995	1.3151069605	1.5321112995	1.3151069605	1.16500888940432	0.383394	0	0.858362549071455	0.383094	0	GO:0016021,integral component of membrane;GO:0016020,membrane		GO:0072657,protein localization to membrane	
CYBC1_HUMAN	Q9BQA9	CYBC1	Cytochrome b-245 chaperone 1	0.361486054	0.620232105	0.055928728	0.234984692	0.4908590795	0.14545671	0.4908590795	0.14545671	3.37460595320766	0.116434	0	0.29633089429285	0.115888	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane		GO:0045087,innate immune response;GO:0045728,respiratory burst after phagocytosis	
ODBA_HUMAN	P12694	BCKDHA	2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial	0.059995026	0.074124618	0.276034148	0.11147692	0.067059822	0.193755534	0.067059822	0.193755534	0.346105324661333	0.093898	0	2.88929389046097	0.094190	0	GO:0005947,mitochondrial alpha-ketoglutarate dehydrogenase complex;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0003863,3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity;GO:0003826,alpha-ketoacid dehydrogenase activity;GO:0016831,carboxy-lyase activity;GO:0046872,metal ion binding	GO:0009083,branched-chain amino acid catabolic process	hsa:593,path:hsa00640,Propanoate metabolism;hsa:593,path:hsa00280,Valine, leucine and isoleucine degradation
RAP2B_HUMAN	P61225	RAP2B	Ras-related protein Rap-2b	3.0204172	5.82045546	0.425052091	0.840232252	4.42043633	0.6326421715	4.42043633	0.6326421715	6.98726156607472	0.035424	1	0.14311758484258	0.035101	-1	GO:0005923,bicellular tight junction;GO:0044291,cell-cell contact zone;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0045121,membrane raft;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0035579,specific granule membrane;GO:0070821,tertiary granule membrane	GO:0003925,G protein activity;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0019904,protein domain specific binding	GO:0030336,negative regulation of cell migration;GO:0043312,neutrophil degranulation;GO:0030168,platelet activation;GO:0070527,platelet aggregation;GO:0031954,positive regulation of protein autophosphorylation;GO:0032486,Rap protein signal transduction;GO:0061097,regulation of protein tyrosine kinase activity;GO:0007165,signal transduction	
RPAB1_HUMAN	P19388	POLR2E	DNA-directed RNA polymerases I, II, and III subunit RPABC1	0.613733378	0.23871894	0.37011541	1.470036963	0.426226159	0.9200761865	0.426226159	0.9200761865	0.463250940795869	0.191710	0	2.158657245859	0.192046	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005736,RNA polymerase I complex;GO:0005665,RNA polymerase II, core complex;GO:0005666,RNA polymerase III complex	GO:0003677,DNA binding;GO:0003899,DNA-directed 5'-3' RNA polymerase activity	GO:0006370,7-methylguanosine mRNA capping;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0000398,mRNA splicing, via spliceosome;GO:0048239,negative regulation of DNA recombination at telomere;GO:0045815,positive regulation of gene expression, epigenetic;GO:0032481,positive regulation of type I interferon production;GO:0050434,positive regulation of viral transcription;GO:0060964,regulation of gene silencing by miRNA;GO:0016070,RNA metabolic process;GO:0042795,snRNA transcription by RNA polymerase II;GO:0006363,termination of RNA polymerase I transcription;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter;GO:0006361,transcription initiation from RNA polymerase I promoter;GO:0006367,transcription initiation from RNA polymerase II promoter;GO:0006351,transcription, DNA-templated;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0016032,viral process	hsa:5434,path:hsa03020,RNA polymerase;hsa:5434,path:hsa04623,Cytosolic DNA-sensing pathway;hsa:5434,path:hsa05016,Huntington disease
PSDE_HUMAN	O00487	PSMD14	26S proteasome non-ATPase regulatory subunit 14	4.921685365	1.690819018	1.410906212	0.843487353	3.3062521915	1.1271967825	3.3062521915	1.1271967825	2.93316326202342	0.141224	0	0.340928857574112	0.140659	0	GO:0005829,cytosol;GO:0031597,cytosolic proteasome complex;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0022624,proteasome accessory complex;GO:0000502,proteasome complex;GO:0008541,proteasome regulatory particle, lid subcomplex;GO:0034774,secretory granule lumen	GO:0061133,endopeptidase activator activity;GO:0070122,isopeptidase activity;GO:0061578,Lys63-specific deubiquitinase activity;GO:0046872,metal ion binding;GO:0008237,metallopeptidase activity;GO:0070628,proteasome binding;GO:0004843,thiol-dependent deubiquitinase	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0000724,double-strand break repair via homologous recombination;GO:0006303,double-strand break repair via nonhomologous end joining;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0043312,neutrophil degranulation;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0070536,protein K63-linked deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061136,regulation of proteasomal protein catabolic process;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0045471,response to ethanol;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:10213,path:hsa03050,Proteasome;hsa:10213,path:hsa05169,Epstein-Barr virus infection
C1TC_HUMAN	P11586	MTHFD1	C-1-tetrahydrofolate synthase, cytoplasmic	5.039650908	2.736365389	6.384663753	5.8834614	3.8880081485	6.1340625765	3.8880081485	6.1340625765	0.633839009630455	0.347354	0	1.57768768536829	0.347604	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0004329,formate-tetrahydrofolate ligase activity;GO:0004477,methenyltetrahydrofolate cyclohydrolase activity;GO:0004487,methylenetetrahydrofolate dehydrogenase (NAD+) activity;GO:0004488,methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0004486,methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	GO:0009257,10-formyltetrahydrofolate biosynthetic process;GO:0048702,embryonic neurocranium morphogenesis;GO:0048703,embryonic viscerocranium morphogenesis;GO:0046655,folic acid metabolic process;GO:0007507,heart development;GO:0000105,histidine biosynthetic process;GO:0009086,methionine biosynthetic process;GO:0006555,methionine metabolic process;GO:0001843,neural tube closure;GO:0006730,one-carbon metabolic process;GO:0006164,purine nucleotide biosynthetic process;GO:0009070,serine family amino acid biosynthetic process;GO:0009069,serine family amino acid metabolic process;GO:0061053,somite development;GO:0035999,tetrahydrofolate interconversion;GO:0001780,neutrophil homeostasis;GO:0019346,transsulfuration	hsa:4522,path:hsa00670,One carbon pool by folate
STIP1_HUMAN	P31948	STIP1	Stress-induced-phosphoprotein 1	7.32300182	5.343755215	9.699585185	7.587064237	6.3333785175	8.643324711	6.3333785175	8.643324711	0.732747956285823	0.432162	0	1.36472574426387	0.432328	0	GO:0101031,chaperone complex;GO:0005829,cytosol;GO:0120293,dynein axonemal particle;GO:0005794,Golgi apparatus;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0051087,chaperone binding;GO:0030544,Hsp70 protein binding;GO:0051879,Hsp90 protein binding;GO:0008022,protein C-terminus binding;GO:0003723,RNA binding	GO:0098761,cellular response to interleukin-7	hsa:10963,path:hsa05020,Prion diseases
DYL2_HUMAN	Q96FJ2	DYNLL2	Dynein light chain 2, cytoplasmic	0.913715272	1.590118566	0.818981969	1.275426594	1.251916919	1.0472042815	1.251916919	1.0472042815	1.19548491265407	0.375112	0	0.836480652675004	0.374795	0	GO:0097731,9+0 non-motile cilium;GO:0005813,centrosome;GO:0097542,ciliary tip;GO:0005929,cilium;GO:0005868,cytoplasmic dynein complex;GO:0005829,cytosol;GO:0030286,dynein complex;GO:0098978,glutamatergic synapse;GO:0016020,membrane;GO:0005874,microtubule;GO:0031475,myosin V complex;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0098794,postsynapse;GO:0014069,postsynaptic density	GO:0045505,dynein intermediate chain binding;GO:0051959,dynein light intermediate chain binding;GO:0042802,identical protein binding;GO:0044877,protein-containing complex binding;GO:0097110,scaffold protein binding	GO:0035973,aggrephagy;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0060271,cilium assembly;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0035735,intraciliary transport involved in cilium assembly;GO:0016236,macroautophagy;GO:0007052,mitotic spindle organization;GO:2000582,positive regulation of ATP-dependent microtubule motor activity, plus-end-directed;GO:0019058,viral life cycle	hsa:140735,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:140735,path:hsa05132,Salmonella infection
ARRB2_HUMAN	P32121	ARRB2	Beta-arrestin-2	0.127935857	0.168017055	0.413816645	0.356905602	0.147976456	0.3853611235	0.147976456	0.3853611235	0.383994251044371	0.123357	0	2.60420565485093	0.123675	0	GO:0016323,basolateral plasma membrane;GO:0005905,clathrin-coated pit;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0030139,endocytic vesicle;GO:0005768,endosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0045211,postsynaptic membrane	GO:0071889,14-3-3 protein binding;GO:0031691,alpha-1A adrenergic receptor binding;GO:0031692,alpha-1B adrenergic receptor binding;GO:0031701,angiotensin receptor binding;GO:1990763,arrestin family protein binding;GO:0031748,D1 dopamine receptor binding;GO:0019899,enzyme binding;GO:0031762,follicle-stimulating hormone receptor binding;GO:0001664,G protein-coupled receptor binding;GO:0042802,identical protein binding;GO:0051019,mitogen-activated protein kinase binding;GO:0031859,platelet activating factor receptor binding;GO:0019904,protein domain specific binding;GO:0043422,protein kinase B binding;GO:0044877,protein-containing complex binding;GO:0005102,signaling receptor binding;GO:0031702,type 1 angiotensin receptor binding;GO:0031826,type 2A serotonin receptor binding;GO:0031625,ubiquitin protein ligase binding	GO:0007628,adult walking behavior;GO:0007420,brain development;GO:0060326,cell chemotaxis;GO:0002032,desensitization of G protein-coupled receptor signaling pathway by arrestin;GO:0050965,detection of temperature stimulus involved in sensory perception of pain;GO:0007212,dopamine receptor signaling pathway;GO:0060079,excitatory postsynaptic potential;GO:0042699,follicle-stimulating hormone signaling pathway;GO:0002031,G protein-coupled receptor internalization;GO:0007186,G protein-coupled receptor signaling pathway;GO:0061024,membrane organization;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0034260,negative regulation of GTPase activity;GO:0032691,negative regulation of interleukin-1 beta production;GO:0032695,negative regulation of interleukin-12 production;GO:0032715,negative regulation of interleukin-6 production;GO:0045953,negative regulation of natural killer cell mediated cytotoxicity;GO:0043524,negative regulation of neuron apoptotic process;GO:0032088,negative regulation of NF-kappaB transcription factor activity;GO:0051898,negative regulation of protein kinase B signaling;GO:0001933,negative regulation of protein phosphorylation;GO:0031397,negative regulation of protein ubiquitination;GO:0090201,negative regulation of release of cytochrome c from mitochondria;GO:0034392,negative regulation of smooth muscle cell apoptotic process;GO:0034122,negative regulation of toll-like receptor signaling pathway;GO:0032720,negative regulation of tumor necrosis factor production;GO:0030168,platelet activation;GO:0051928,positive regulation of calcium ion transport;GO:2000727,positive regulation of cardiac muscle cell differentiation;GO:0032967,positive regulation of collagen biosynthetic process;GO:2000573,positive regulation of DNA biosynthetic process;GO:1904037,positive regulation of epithelial cell apoptotic process;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0010628,positive regulation of gene expression;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0051897,positive regulation of protein kinase B signaling;GO:0002092,positive regulation of receptor internalization;GO:0032226,positive regulation of synaptic transmission, dopaminergic;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0015031,protein transport;GO:0016567,protein ubiquitination;GO:0031623,receptor internalization;GO:0006366,transcription by RNA polymerase II;GO:0007179,transforming growth factor beta receptor signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0007165,signal transduction	hsa:409,path:hsa04010,MAPK signaling pathway;hsa:409,path:hsa04340,Hedgehog signaling pathway;hsa:409,path:hsa04144,Endocytosis;hsa:409,path:hsa04062,Chemokine signaling pathway;hsa:409,path:hsa04929,GnRH secretion;hsa:409,path:hsa04926,Relaxin signaling pathway;hsa:409,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:409,path:hsa04728,Dopaminergic synapse;hsa:409,path:hsa04740,Olfactory transduction;hsa:409,path:hsa05032,Morphine addiction
MYL6_HUMAN	P60660	MYL6	Myosin light polypeptide 6	89.88271235	198.7818963	7.875868055	8.833335993	144.332304325	8.354602024	144.332304325	8.354602024	17.27578452096	0.005093	1	0.0578844913692193	0.005008	-1	GO:0005903,brush border;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0016459,myosin complex;GO:0016461,unconventional myosin complex;GO:0031982,vesicle	GO:0030898,actin-dependent ATPase activity;GO:0005509,calcium ion binding;GO:0003774,motor activity;GO:0008307,structural constituent of muscle	GO:0006936,muscle contraction;GO:0030049,muscle filament sliding;GO:0007519,skeletal muscle tissue development	hsa:4637,path:hsa04530,Tight junction;hsa:4637,path:hsa04921,Oxytocin signaling pathway;hsa:4637,path:hsa04270,Vascular smooth muscle contraction;hsa:4637,path:hsa05132,Salmonella infection
RRBP1_HUMAN	Q9P2E9	RRBP1	Ribosome-binding protein 1	19.73196649	19.34909927	20.39689517	24.41412415	19.54053288	22.40550966	19.54053288	22.40550966	0.872130702515785	0.479053	0	1.14661712644144	0.478956	0	GO:0005783,endoplasmic reticulum;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016020,membrane;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0038023,signaling receptor activity	GO:0001649,osteoblast differentiation;GO:0015031,protein transport;GO:0006412,translation	hsa:6238,path:hsa04141,Protein processing in endoplasmic reticulum
FKBP3_HUMAN	Q00688	FKBP3	Peptidyl-prolyl cis-trans isomerase FKBP3	1.335723366	0.372407836	1.031399576	0.181400071	0.854065601	0.6063998235	0.854065601	0.6063998235	1.40841993665257	0.324014	0	0.710015510272261	0.323603	0	GO:0005634,nucleus	GO:0005528,FK506 binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity;GO:0003723,RNA binding;GO:0038023,signaling receptor activity		
EPB41_HUMAN	P11171	EPB41	Protein 4.1	0.800540303	0.407749542	1.538295519	21.62375384	0.6041449225	11.5810246795	0.6041449225	11.5810246795	0.0521667934590813	0.000013	-1	19.1692824820521	0.000013	1	GO:0016323,basolateral plasma membrane;GO:0099738,cell cortex region;GO:0030054,cell junction;GO:0030863,cortical cytoskeleton;GO:0009898,cytoplasmic side of plasma membrane;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0045171,intercellular bridge;GO:0072686,mitotic spindle;GO:0016604,nuclear body;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0032991,protein-containing complex;GO:0014731,spectrin-associated cytoskeleton;GO:0005938,cell cortex;GO:0005634,nucleus;GO:0016021,integral component of membrane	GO:0005545,1-phosphatidylinositol binding;GO:0003779,actin binding;GO:0005516,calmodulin binding;GO:0051219,phosphoprotein binding;GO:0008022,protein C-terminus binding;GO:0047485,protein N-terminus binding;GO:0030507,spectrin binding;GO:0005200,structural constituent of cytoskeleton;GO:0008092,cytoskeletal protein binding;GO:0005198,structural molecule activity	GO:0030036,actin cytoskeleton organization;GO:0031032,actomyosin structure organization;GO:0007049,cell cycle;GO:0051301,cell division;GO:0030866,cortical actin cytoskeleton organization;GO:0032092,positive regulation of protein binding;GO:1904778,positive regulation of protein localization to cell cortex;GO:0065003,protein-containing complex assembly;GO:0051924,regulation of calcium ion transport;GO:0008360,regulation of cell shape;GO:1904478,regulation of intestinal absorption	
PA2G4_HUMAN	Q9UQ80	PA2G4	Proliferation-associated protein 2G4	5.324407619	3.952205493	6.589357853	4.799749827	4.638306556	5.69455384	4.638306556	5.69455384	0.814516235393079	0.496330	0	1.22772261195924	0.496425	0	GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005634,nucleus	GO:0003676,nucleic acid binding;GO:0003723,RNA binding;GO:0003714,transcription corepressor activity;GO:0031625,ubiquitin protein ligase binding	GO:0043066,negative regulation of apoptotic process;GO:0045892,negative regulation of transcription, DNA-templated;GO:0043312,neutrophil degranulation;GO:0045597,positive regulation of cell differentiation;GO:0006417,regulation of translation;GO:0006364,rRNA processing	
RS2_HUMAN	P15880	RPS2	40S ribosomal protein S2	15.70288766	48.765951	5.053246267	2.630938633	32.23441933	3.84209245	32.23441933	3.84209245	8.38980835299786	0.024961	1	0.119192233949263	0.024699	-1	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0015935,small ribosomal subunit;GO:0005840,ribosome	GO:0045296,cadherin binding;GO:0019899,enzyme binding;GO:0017134,fibroblast growth factor binding;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0051443,positive regulation of ubiquitin-protein transferase activity;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6187,path:hsa03010,Ribosome
AP1G1_HUMAN	O43747	AP1G1	AP-1 complex subunit gamma-1	1.866812816	1.863444009	2.400781035	2.18680584	1.8651284125	2.2937934375	1.8651284125	2.2937934375	0.813119604410761	0.495284	0	1.2298313736079	0.495380	0	GO:0030121,AP-1 adaptor complex;GO:0030136,clathrin-coated vesicle;GO:0030665,clathrin-coated vesicle membrane;GO:0005737,cytoplasm;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm;GO:0055037,recycling endosome;GO:0032588,trans-Golgi network membrane;GO:0030117,membrane coat	GO:0140312,cargo adaptor activity;GO:0035615,clathrin adaptor activity;GO:0030742,GTP-dependent protein binding;GO:0019894,kinesin binding;GO:0031267,small GTPase binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0035646,endosome to melanosome transport;GO:0090160,Golgi to lysosome transport;GO:0006896,Golgi to vacuole transport;GO:0006886,intracellular protein transport;GO:0032438,melanosome organization;GO:0043323,positive regulation of natural killer cell degranulation;GO:0045954,positive regulation of natural killer cell mediated cytotoxicity;GO:0006892,post-Golgi vesicle-mediated transport;GO:0006898,receptor-mediated endocytosis;GO:0050690,regulation of defense response to virus by virus;GO:0016192,vesicle-mediated transport	hsa:164,path:hsa04142,Lysosome;hsa:164,path:hsa05170,Human immunodeficiency virus 1 infection
RL26_HUMAN	P61254	RPL26	60S ribosomal protein L26	6.216800812	5.18234683	0.45259383	0.637907263	5.699573821	0.5452505465	5.699573821	0.5452505465	10.4531281217157	0.015938	1	0.0956651433289682	0.015743	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:1990904,ribonucleoprotein complex;GO:0015934,large ribosomal subunit	GO:0048027,mRNA 5'-UTR binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0071480,cellular response to gamma radiation;GO:0034644,cellular response to UV;GO:0002181,cytoplasmic translation;GO:0006977,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:1902164,positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:1902167,positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0045727,positive regulation of translation;GO:1904803,regulation of translation involved in cellular response to UV;GO:0042273,ribosomal large subunit biogenesis;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6154,path:hsa03010,Ribosome
UCHL3_HUMAN	P15374	UCHL3	Ubiquitin carboxyl-terminal hydrolase isozyme L3	0.17979558	1.10898005	0.436429751	0.233805677	0.644387815	0.335117714	0.644387815	0.335117714	1.92287004858239	0.236092	0	0.520055944881577	0.235560	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm	GO:0008233,peptidase activity;GO:0004843,thiol-dependent deubiquitinase;GO:0043130,ubiquitin binding	GO:0043687,post-translational protein modification;GO:0030163,protein catabolic process;GO:0016579,protein deubiquitination;GO:0016567,protein ubiquitination;GO:0006511,ubiquitin-dependent protein catabolic process	
SPCS1_HUMAN	Q9Y6A9	SPCS1	Signal peptidase complex subunit 1	0.273754681	0.181136765	0.616798229	0.247456879	0.227445723	0.432127554	0.227445723	0.432127554	0.526339320172117	0.249364	0	1.89991505797627	0.249683	0	GO:0005789,endoplasmic reticulum membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0005787,signal peptidase complex;GO:0016021,integral component of membrane	GO:0008233,peptidase activity;GO:0043022,ribosome binding	GO:0045047,protein targeting to ER;GO:0006508,proteolysis;GO:0006465,signal peptide processing;GO:0019082,viral protein processing;GO:0019068,virion assembly	hsa:28972,path:hsa03060,Protein export
CNOT9_HUMAN	Q92600	CNOT9	CCR4-NOT transcription complex subunit 9	0.04345025	0.03564702	0.120713798	0.020581856	0.039548635	0.070647827	0.039548635	0.070647827	0.559799737364887	0.280181	0	1.78635310675071	0.280483	0	GO:0030014,CCR4-NOT complex;GO:0030015,CCR4-NOT core complex;GO:0005829,cytosol;GO:0016020,membrane;GO:0005634,nucleus;GO:0000932,P-body;GO:0032991,protein-containing complex	GO:0005154,epidermal growth factor receptor binding;GO:0019900,kinase binding;GO:0030374,nuclear receptor coactivator activity;GO:0019904,protein domain specific binding;GO:0042803,protein homodimerization activity	GO:0019221,cytokine-mediated signaling pathway;GO:0006977,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0031047,gene silencing by RNA;GO:0033147,negative regulation of intracellular estrogen receptor signaling pathway;GO:0017148,negative regulation of translation;GO:0000289,nuclear-transcribed mRNA poly(A) tail shortening;GO:0045742,positive regulation of epidermal growth factor receptor signaling pathway;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0007548,sex differentiation;GO:0006402,mRNA catabolic process	hsa:9125,path:hsa03018,RNA degradation
PPP5_HUMAN	P53041	PPP5C	Serine/threonine-protein phosphatase 5	0.965736729	0.523954178	1.223540968	0.524152228	0.7448454535	0.873846598	0.7448454535	0.873846598	0.852375525870045	0.486750	0	1.17319182643034	0.486670	0	GO:0101031,chaperone complex;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0043204,perikaryon;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:1990635,proximal dendrite;GO:0005737,cytoplasm	GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0001965,G-protein alpha-subunit binding;GO:0051879,Hsp90 protein binding;GO:0042802,identical protein binding;GO:0008289,lipid binding;GO:0046872,metal ion binding;GO:0008017,microtubule binding;GO:0016791,phosphatase activity;GO:0004721,phosphoprotein phosphatase activity;GO:0106306,protein serine phosphatase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0106307,protein threonine phosphatase activity;GO:0044877,protein-containing complex binding;GO:0003723,RNA binding;GO:0048156,tau protein binding	GO:0071276,cellular response to cadmium ion;GO:0070301,cellular response to hydrogen peroxide;GO:0006302,double-strand break repair;GO:0016576,histone dephosphorylation;GO:0000165,MAPK cascade;GO:0000278,mitotic cell cycle;GO:1901215,negative regulation of neuron death;GO:0001933,negative regulation of protein phosphorylation;GO:0070262,peptidyl-serine dephosphorylation;GO:0035970,peptidyl-threonine dephosphorylation;GO:2000324,positive regulation of glucocorticoid receptor signaling pathway;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0006470,protein dephosphorylation;GO:1904550,response to arachidonic acid;GO:0010288,response to lead ion;GO:0043278,response to morphine;GO:0006351,transcription, DNA-templated	hsa:5536,path:hsa04010,MAPK signaling pathway
PSA_HUMAN	P55786	NPEPPS	Puromycin-sensitive aminopeptidase	10.2184309	10.59263946	11.63791573	12.18538958	10.40553518	11.911652655	10.40553518	11.911652655	0.873559318876899	0.478503	0	1.14474195213859	0.478405	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0004177,aminopeptidase activity;GO:0070006,metalloaminopeptidase activity;GO:0042277,peptide binding;GO:0008270,zinc ion binding;GO:0008237,metallopeptidase activity	GO:0071456,cellular response to hypoxia;GO:0043171,peptide catabolic process;GO:1903955,positive regulation of protein targeting to mitochondrion;GO:0000209,protein polyubiquitination;GO:0006508,proteolysis	
DSC2_HUMAN	Q02487	DSC2	Desmocollin-2	0.059556968	0.052259129	0.021533769	2.55E-05	0.0559080485	0.0107796345	0.0559080485	0.0107796345	5.1864512196587	0.059944	0	0.192810065620516	0.059517	0	GO:0005912,adherens junction;GO:0005911,cell-cell junction;GO:0001533,cornified envelope;GO:0031410,cytoplasmic vesicle;GO:0030057,desmosome;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0014704,intercalated disc;GO:0005886,plasma membrane	GO:0005509,calcium ion binding;GO:0086083,cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	GO:0086073,bundle of His cell-Purkinje myocyte adhesion involved in cell communication;GO:0086042,cardiac muscle cell-cardiac muscle cell adhesion;GO:0007155,cell adhesion;GO:0098609,cell-cell adhesion;GO:0009267,cellular response to starvation;GO:0070268,cornification;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0031424,keratinization;GO:0086091,regulation of heart rate by cardiac conduction;GO:0098911,regulation of ventricular cardiac muscle cell action potential	hsa:1824,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GPX2_HUMAN	P18283	GPX2	Glutathione peroxidase 2	2.449451688	2.436636824	0.293772371	0.566664646	2.443044256	0.4302185085	2.443044256	0.4302185085	5.67861262993524	0.051376	0	0.176099351226816	0.050980	0	GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0009055,electron transfer activity;GO:0004602,glutathione peroxidase activity;GO:0004601,peroxidase activity	GO:0034599,cellular response to oxidative stress;GO:0006979,response to oxidative stress	hsa:2877,path:hsa00590,Arachidonic acid metabolism;hsa:2877,path:hsa00480,Glutathione metabolism;hsa:2877,path:hsa04918,Thyroid hormone synthesis;hsa:2877,path:hsa05014,Amyotrophic lateral sclerosis (ALS);hsa:2877,path:hsa05016,Huntington disease
SYTM_HUMAN	Q9BW92	TARS2	Threonine--tRNA ligase, mitochondrial	0.149332621	0.134273139	0.248987583	0.11902911	0.14180288	0.1840083465	0.14180288	0.1840083465	0.770632869091077	0.462620	0	1.29763476242514	0.462753	0	GO:0005759,mitochondrial matrix;GO:0005737,cytoplasm	GO:0002161,aminoacyl-tRNA editing activity;GO:0005524,ATP binding;GO:0042803,protein homodimerization activity;GO:0004829,threonine-tRNA ligase activity	GO:0070159,mitochondrial threonyl-tRNA aminoacylation;GO:0006435,threonyl-tRNA aminoacylation	hsa:80222,path:hsa00970,Aminoacyl-tRNA biosynthesis
ACTBL_HUMAN	Q562R1	ACTBL2	Beta-actin-like protein 2	0.264160752	0.153568157	0.476894704	0.235928916	0.2088644545	0.35641181	0.2088644545	0.35641181	0.586020015722824	0.304203	0	1.70642635604614	0.304488	0	GO:0005884,actin filament;GO:0030424,axon;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0098978,glutamatergic synapse;GO:0016020,membrane;GO:0035267,NuA4 histone acetyltransferase complex;GO:0045202,synapse	GO:0005524,ATP binding;GO:0019901,protein kinase binding;GO:0098973,structural constituent of postsynaptic actin cytoskeleton	GO:0007409,axonogenesis;GO:0048870,cell motility	
RS3A_HUMAN	P61247	RPS3A	40S ribosomal protein S3a	10.75750468	31.93017126	3.437740398	0.947341501	21.34383797	2.1925409495	21.34383797	2.1925409495	9.73474998260232	0.018491	1	0.102724774831113	0.018276	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0005840,ribosome	GO:0048027,mRNA 5'-UTR binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0030154,cell differentiation;GO:0002181,cytoplasmic translation;GO:0043066,negative regulation of apoptotic process;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6189,path:hsa03010,Ribosome
MACF1_HUMAN	Q9UPN3	MACF1	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5	2.907852496	4.682403825	4.745160123	11.55789571	3.7951281605	8.1515279165	3.7951281605	8.1515279165	0.465572614039394	0.193802	0	2.14789265915754	0.194137	0	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005794,Golgi apparatus;GO:0016020,membrane;GO:0005874,microtubule;GO:0005886,plasma membrane;GO:0032587,ruffle membrane;GO:0042995,cell projection;GO:0030054,cell junction;GO:0016021,integral component of membrane	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0016887,ATPase activity;GO:0045296,cadherin binding;GO:0005509,calcium ion binding;GO:0051011,microtubule minus-end binding;GO:0003723,RNA binding;GO:0005198,structural molecule activity;GO:0008017,microtubule binding;GO:0008092,cytoskeletal protein binding	GO:0043001,Golgi to plasma membrane protein transport;GO:0045104,intermediate filament cytoskeleton organization;GO:0045773,positive regulation of axon extension;GO:0030177,positive regulation of Wnt signaling pathway;GO:0030334,regulation of cell migration;GO:0010632,regulation of epithelial cell migration;GO:0051893,regulation of focal adhesion assembly;GO:0032886,regulation of microtubule-based process;GO:0150011,regulation of neuron projection arborization;GO:0016055,Wnt signaling pathway;GO:0042060,wound healing	
NOC2L_HUMAN	Q9Y3T9	NOC2L	Nucleolar complex protein 2 homolog	0.426178195	0.319077962	0.584311423	0.521641632	0.3726280785	0.5529765275	0.3726280785	0.5529765275	0.673858762477038	0.382505	0	1.48399049724322	0.382722	0	GO:0005694,chromosome;GO:0005829,cytosol;GO:0030690,Noc1p-Noc2p complex;GO:0030691,Noc2p-Noc3p complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003682,chromatin binding;GO:0042393,histone binding;GO:0031491,nucleosome binding;GO:0070491,repressing transcription factor binding;GO:0003723,RNA binding;GO:0003714,transcription corepressor activity	GO:0006915,apoptotic process;GO:0034644,cellular response to UV;GO:0031497,chromatin assembly;GO:0002903,negative regulation of B cell apoptotic process;GO:0035067,negative regulation of histone acetylation;GO:2001243,negative regulation of intrinsic apoptotic signaling pathway;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0042273,ribosomal large subunit biogenesis	
LEG8_HUMAN	O00214	LGALS8	Galectin-8	0.22217166	0.399217646	0.199036687	0.114848224	0.310694653	0.1569424555	0.310694653	0.1569424555	1.97967243477977	0.228600	0	0.505134072905979	0.228060	0	GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005615,extracellular space;GO:0016020,membrane	GO:0030246,carbohydrate binding;GO:0005178,integrin binding	GO:0098586,cellular response to virus;GO:1904977,lymphatic endothelial cell migration;GO:0098792,xenophagy	
ERGI2_HUMAN	Q96RQ1	ERGIC2	Endoplasmic reticulum-Golgi intermediate compartment protein 2	0.310503739	0.256765627	0.309878861	0.235376844	0.283634683	0.2726278525	0.283634683	0.2726278525	1.04037309614211	0.420268	0	0.961193636886784	0.420043	0	GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005634,nucleus		GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0016192,vesicle-mediated transport	
NOP2_HUMAN	P46087	NOP2	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase	0.146098184	0.237690357	0.357538511	0.093804626	0.1918942705	0.2256715685	0.1918942705	0.2256715685	0.850325416602047	0.487559	0	1.17602035700175	0.487481	0	GO:0005730,nucleolus;GO:0005654,nucleoplasm	GO:0003723,RNA binding;GO:0009383,rRNA (cytosine-C5-)-methyltransferase activity;GO:0008168,methyltransferase activity	GO:0000470,maturation of LSU-rRNA;GO:0008284,positive regulation of cell population proliferation;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0006357,regulation of transcription by RNA polymerase II;GO:0000027,ribosomal large subunit assembly;GO:0001510,RNA methylation;GO:0070475,rRNA base methylation;GO:0032259,methylation	
ADSV_HUMAN	Q9Y6U3	SCIN	Adseverin	0.914552669	0.392895242	0.916486054	1.612392278	0.6537239555	1.264439166	0.6537239555	1.264439166	0.517007043975099	0.240769	0	1.93420962374386	0.241091	0	GO:0015629,actin cytoskeleton;GO:0005938,cell cortex;GO:0030054,cell junction;GO:0042995,cell projection;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005886,plasma membrane;GO:0002102,podosome;GO:0032991,protein-containing complex	GO:0005545,1-phosphatidylinositol binding;GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0005509,calcium ion binding;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding;GO:0001786,phosphatidylserine binding	GO:0051693,actin filament capping;GO:0051014,actin filament severing;GO:0045010,actin nucleation;GO:0008154,actin polymerization or depolymerization;GO:0051016,barbed-end actin filament capping;GO:0017156,calcium-ion regulated exocytosis;GO:0030031,cell projection assembly;GO:0007417,central nervous system development;GO:0008285,negative regulation of cell population proliferation;GO:0051127,positive regulation of actin nucleation;GO:0043065,positive regulation of apoptotic process;GO:0045654,positive regulation of megakaryocyte differentiation;GO:0051047,positive regulation of secretion;GO:0032330,regulation of chondrocyte differentiation;GO:0042989,sequestering of actin monomers	hsa:85477,path:hsa04810,Regulation of actin cytoskeleton;hsa:85477,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:85477,path:hsa05203,Viral carcinogenesis
SEP11_HUMAN	Q9NVA2	SEPTIN11	Septin-11	6.028085273	6.521113186	7.806012196	11.71423674	6.2745992295	9.760124468	6.2745992295	9.760124468	0.642881066739691	0.355383	0	1.55549766782121	0.355626	0	GO:0030424,axon;GO:0032153,cell division site;GO:0043197,dendritic spine;GO:0098982,GABA-ergic synapse;GO:0098978,glutamatergic synapse;GO:0015630,microtubule cytoskeleton;GO:0099629,postsynaptic specialization of symmetric synapse;GO:0031105,septin complex;GO:0005940,septin ring;GO:0001725,stress fiber;GO:0005856,cytoskeleton	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0060090,molecular adaptor activity	GO:0034613,cellular protein localization;GO:0061640,cytoskeleton-dependent cytokinesis;GO:0050807,regulation of synapse organization	hsa:55752,path:hsa05131,Shigellosis;hsa:55752,path:hsa05100,Bacterial invasion of epithelial cells
AQP1_HUMAN	P29972	AQP1	Aquaporin-1	2.55E-05	0.200833102	0.270656013	1.263735828	0.100429301	0.7671959205	0.100429301	0.7671959205	0.130904373076629	0.002532	-1	7.63916419671187	0.002559	1	GO:0045177,apical part of cell;GO:0016324,apical plasma membrane;GO:0009925,basal plasma membrane;GO:0016323,basolateral plasma membrane;GO:0005903,brush border;GO:0031526,brush border membrane;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0031965,nuclear membrane;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0042383,sarcolemma;GO:0020003,symbiont-containing vacuole	GO:0008519,ammonium transmembrane transporter activity;GO:0035379,carbon dioxide transmembrane transporter activity;GO:0015168,glycerol transmembrane transporter activity;GO:0042802,identical protein binding;GO:0005223,intracellular cGMP-activated cation channel activity;GO:0030184,nitric oxide transmembrane transporter activity;GO:0005267,potassium channel activity;GO:0015079,potassium ion transmembrane transporter activity;GO:0022857,transmembrane transporter activity;GO:0015250,water channel activity;GO:0005372,water transmembrane transporter activity;GO:0015267,channel activity	GO:0015696,ammonium transport;GO:0015701,bicarbonate transport;GO:0035378,carbon dioxide transmembrane transport;GO:0015670,carbon dioxide transport;GO:0006884,cell volume homeostasis;GO:0019725,cellular homeostasis;GO:0071474,cellular hyperosmotic response;GO:0071320,cellular response to cAMP;GO:0071280,cellular response to copper ion;GO:0071549,cellular response to dexamethasone stimulus;GO:0070301,cellular response to hydrogen peroxide;GO:0071456,cellular response to hypoxia;GO:0071241,cellular response to inorganic substance;GO:0071260,cellular response to mechanical stimulus;GO:0071288,cellular response to mercury ion;GO:0071732,cellular response to nitric oxide;GO:0071300,cellular response to retinoic acid;GO:0071472,cellular response to salt stress;GO:0034644,cellular response to UV;GO:0009992,cellular water homeostasis;GO:0033326,cerebrospinal fluid secretion;GO:0019934,cGMP-mediated signaling;GO:0050829,defense response to Gram-negative bacterium;GO:0030950,establishment or maintenance of actin cytoskeleton polarity;GO:0015793,glycerol transport;GO:0006972,hyperosmotic response;GO:0021670,lateral ventricle development;GO:0085018,maintenance of symbiont-containing vacuole by host;GO:0050891,multicellular organismal water homeostasis;GO:0043066,negative regulation of apoptotic process;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0030185,nitric oxide transport;GO:0042476,odontogenesis;GO:0030157,pancreatic juice secretion;GO:0045766,positive regulation of angiogenesis;GO:0048146,positive regulation of fibroblast proliferation;GO:0046878,positive regulation of saliva secretion;GO:0006813,potassium ion transport;GO:0003091,renal water homeostasis;GO:0003097,renal water transport;GO:0035377,transepithelial water transport;GO:0006833,water transport	hsa:358,path:hsa04924,Renin secretion;hsa:358,path:hsa04976,Bile secretion;hsa:358,path:hsa04964,Proximal tubule bicarbonate reclamation
ASM3B_HUMAN	Q92485	SMPDL3B	Acid sphingomyelinase-like phosphodiesterase 3b	0.231649586	0.023303454	0.187789165	0.100000131	0.12747652	0.143894648	0.12747652	0.143894648	0.885901746672329	0.473794	0	1.12879334955174	0.473685	0	GO:0031225,anchored component of membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005886,plasma membrane;GO:0005576,extracellular region	GO:0016798,hydrolase activity, acting on glycosyl bonds;GO:0008081,phosphoric diester hydrolase activity;GO:0004767,sphingomyelin phosphodiesterase activity;GO:0008270,zinc ion binding;GO:0016787,hydrolase activity;GO:0046872,metal ion binding	GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0046466,membrane lipid catabolic process;GO:0050728,negative regulation of inflammatory response;GO:0034122,negative regulation of toll-like receptor signaling pathway;GO:0006685,sphingomyelin catabolic process	
SNX32_HUMAN	Q86XE0	SNX32	Sorting nexin-32	0.08879221	0.054690976	0.094194243	0.733705886	0.071741593	0.4139500645	0.071741593	0.4139500645	0.173309776111896	0.008795	-1	5.77001495492301	0.008866	1	GO:0005829,cytosol;GO:0005768,endosome	GO:0035091,phosphatidylinositol binding	GO:0015031,protein transport;GO:0016241,regulation of macroautophagy;GO:0042147,retrograde transport, endosome to Golgi	hsa:254122,path:hsa04144,Endocytosis
EF2_HUMAN	P13639	EEF2	Elongation factor 2	75.59734855	60.27248957	75.66915196	42.85001368	67.93491906	59.25958282	67.93491906	59.25958282	1.14639549971776	0.388587	0	0.872299307042112	0.388297	0	GO:0016235,aggresome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0045121,membrane raft;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0042788,polysomal ribosome;GO:1990904,ribonucleoprotein complex;GO:0034774,secretory granule lumen;GO:0045202,synapse	GO:0008097,5S rRNA binding;GO:0051015,actin filament binding;GO:0045296,cadherin binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0002039,p53 binding;GO:0019901,protein kinase binding;GO:0043022,ribosome binding;GO:0003723,RNA binding;GO:0003746,translation elongation factor activity	GO:0007568,aging;GO:1990416,cellular response to brain-derived neurotrophic factor stimulus;GO:0014009,glial cell proliferation;GO:0002244,hematopoietic progenitor cell differentiation;GO:0043312,neutrophil degranulation;GO:2000767,positive regulation of cytoplasmic translation;GO:0045727,positive regulation of translation;GO:0042493,response to drug;GO:0034976,response to endoplasmic reticulum stress;GO:0032355,response to estradiol;GO:0045471,response to ethanol;GO:0051593,response to folic acid;GO:0042542,response to hydrogen peroxide;GO:0002931,response to ischemia;GO:0035914,skeletal muscle cell differentiation;GO:0003009,skeletal muscle contraction;GO:0006414,translational elongation	hsa:1938,path:hsa04152,AMPK signaling pathway;hsa:1938,path:hsa04921,Oxytocin signaling pathway
DYST_HUMAN	Q03001	DST	Dystonin	0.616180944	0.070597907	1.58450795	10.54431833	0.3433894255	6.06441314	0.3433894255	6.06441314	0.0566236860142414	0.000022	-1	17.6604539617659	0.000023	1	GO:0015629,actin cytoskeleton;GO:0030424,axon;GO:1904115,axon cytoplasm;GO:0009925,basal plasma membrane;GO:0005604,basement membrane;GO:0005938,cell cortex;GO:0031252,cell leading edge;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0005925,focal adhesion;GO:0031673,H zone;GO:0030056,hemidesmosome;GO:0016021,integral component of membrane;GO:0005882,intermediate filament;GO:0045111,intermediate filament cytoskeleton;GO:0016020,membrane;GO:0015630,microtubule cytoskeleton;GO:0035371,microtubule plus-end;GO:0005635,nuclear envelope;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0030018,Z disc;GO:0005856,cytoskeleton;GO:0042995,cell projection;GO:0005874,microtubule	GO:0003779,actin binding;GO:0005509,calcium ion binding;GO:0005178,integrin binding;GO:0008017,microtubule binding;GO:0051010,microtubule plus-end binding;GO:0008022,protein C-terminus binding;GO:0042803,protein homodimerization activity;GO:0005198,structural molecule activity	GO:0007155,cell adhesion;GO:0048870,cell motility;GO:0030199,collagen fibril organization;GO:0031122,cytoplasmic microtubule organization;GO:0007010,cytoskeleton organization;GO:0031581,hemidesmosome assembly;GO:0007229,integrin-mediated signaling pathway;GO:0045104,intermediate filament cytoskeleton organization;GO:0030011,maintenance of cell polarity;GO:0000226,microtubule cytoskeleton organization;GO:0009611,response to wounding;GO:0008090,retrograde axonal transport;GO:0042060,wound healing	
RIC8A_HUMAN	Q9NPQ8	RIC8A	Synembryn-A	0.340734585	0.28809553	0.529283348	0.823320008	0.3144150575	0.676301678	0.3144150575	0.676301678	0.464903559650787	0.193199	0	2.15098374542701	0.193534	0	GO:0005737,cytoplasm;GO:0005886,plasma membrane	GO:0001965,G-protein alpha-subunit binding;GO:0005096,GTPase activator activity;GO:0005085,guanyl-nucleotide exchange factor activity	GO:0007193,adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0071711,basement membrane organization;GO:0042074,cell migration involved in gastrulation;GO:0070586,cell-cell adhesion involved in gastrulation;GO:0007186,G protein-coupled receptor signaling pathway;GO:0001701,in utero embryonic development;GO:0001944,vasculature development;GO:0008542,visual learning	
RHG17_HUMAN	Q68EM7	ARHGAP17	Rho GTPase-activating protein 17	0.17541162	0.124350529	0.289409422	0.312325429	0.1498810745	0.3008674255	0.1498810745	0.3008674255	0.498163183504889	0.223456	0	2.00737435666035	0.223785	0	GO:0005923,bicellular tight junction;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0005737,cytoplasm	GO:0005096,GTPase activator activity;GO:0017124,SH3 domain binding	GO:0007015,actin filament organization;GO:0017156,calcium-ion regulated exocytosis;GO:0032956,regulation of actin cytoskeleton organization;GO:0035020,regulation of Rac protein signal transduction;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007165,signal transduction	hsa:55114,path:hsa04530,Tight junction
KPCD_HUMAN	Q05655	PRKCD	Protein kinase C delta type	0.548464009	0.789705188	0.814401344	2.142641626	0.6690845985	1.478521485	0.6690845985	1.478521485	0.452536270380948	0.182105	0	2.20976762626826	0.182441	0	GO:0035578,azurophil granule lumen;GO:0005911,cell-cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0036019,endolysosome;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005739,mitochondrion;GO:0016363,nuclear matrix;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane	GO:0005524,ATP binding;GO:0004698,calcium-dependent protein kinase C activity;GO:0004699,calcium-independent protein kinase C activity;GO:0008047,enzyme activator activity;GO:0019899,enzyme binding;GO:0043560,insulin receptor substrate binding;GO:0019900,kinase binding;GO:0046872,metal ion binding;GO:0004715,non-membrane spanning protein tyrosine kinase activity;GO:0004672,protein kinase activity;GO:0019901,protein kinase binding;GO:0004697,protein kinase C activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0004714,transmembrane receptor protein tyrosine kinase activity	GO:0032147,activation of protein kinase activity;GO:0006915,apoptotic process;GO:0042100,B cell proliferation;GO:0060326,cell chemotaxis;GO:0007049,cell cycle;GO:1904385,cellular response to angiotensin;GO:0070301,cellular response to hydrogen peroxide;GO:0071447,cellular response to hydroperoxide;GO:0034644,cellular response to UV;GO:0090398,cellular senescence;GO:0042742,defense response to bacterium;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0016572,histone phosphorylation;GO:0016064,immunoglobulin mediated immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0035556,intracellular signal transduction;GO:0008631,intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0030837,negative regulation of actin filament polymerization;GO:0051490,negative regulation of filopodium assembly;GO:0034351,negative regulation of glial cell apoptotic process;GO:0050728,negative regulation of inflammatory response;GO:0046627,negative regulation of insulin receptor signaling pathway;GO:0043407,negative regulation of MAP kinase activity;GO:0050732,negative regulation of peptidyl-tyrosine phosphorylation;GO:0090331,negative regulation of platelet aggregation;GO:0032091,negative regulation of protein binding;GO:0042119,neutrophil activation;GO:0043312,neutrophil degranulation;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:0030168,platelet activation;GO:2001235,positive regulation of apoptotic signaling pathway;GO:2000304,positive regulation of ceramide biosynthetic process;GO:0032079,positive regulation of endodeoxyribonuclease activity;GO:2000753,positive regulation of glucosylceramide catabolic process;GO:1900163,positive regulation of phospholipid scramblase activity;GO:0035307,positive regulation of protein dephosphorylation;GO:0042307,positive regulation of protein import into nucleus;GO:2001022,positive regulation of response to DNA damage stimulus;GO:2000755,positive regulation of sphingomyelin catabolic process;GO:0032930,positive regulation of superoxide anion generation;GO:0006468,protein phosphorylation;GO:0050821,protein stabilization;GO:0032956,regulation of actin cytoskeleton organization;GO:2000303,regulation of ceramide biosynthetic process;GO:0043488,regulation of mRNA stability;GO:0010469,regulation of signaling receptor activity;GO:0007165,signal transduction;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0023021,termination of signal transduction	hsa:5580,path:hsa04140,Autophagy - animal;hsa:5580,path:hsa04621,NOD-like receptor signaling pathway;hsa:5580,path:hsa04625,C-type lectin receptor signaling pathway;hsa:5580,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:5580,path:hsa04062,Chemokine signaling pathway;hsa:5580,path:hsa04912,GnRH signaling pathway;hsa:5580,path:hsa04915,Estrogen signaling pathway;hsa:5580,path:hsa04270,Vascular smooth muscle contraction;hsa:5580,path:hsa04722,Neurotrophin signaling pathway;hsa:5580,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:5580,path:hsa04930,Type II diabetes mellitus;hsa:5580,path:hsa04931,Insulin resistance;hsa:5580,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:5580,path:hsa05131,Shigellosis
DSC3_HUMAN	Q14574	DSC3	Desmocollin-3	0.383288455	0.481348196	0.323051343	1.280879346	0.4323183255	0.8019653445	0.4323183255	0.8019653445	0.539073575267192	0.261100	0	1.85503435130233	0.261413	0	GO:0030054,cell junction;GO:0005911,cell-cell junction;GO:0001533,cornified envelope;GO:0005737,cytoplasm;GO:0030057,desmosome;GO:0005576,extracellular region;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0005509,calcium ion binding;GO:0045295,gamma-catenin binding	GO:0007155,cell adhesion;GO:0098609,cell-cell adhesion;GO:0070268,cornification;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0001701,in utero embryonic development;GO:0031424,keratinization;GO:0050821,protein stabilization	
PUR9_HUMAN	P31939	ATIC	Bifunctional purine biosynthesis protein ATIC	6.014311895	4.940746853	8.30346599	7.23329729	5.477529374	7.76838164	5.477529374	7.76838164	0.70510559700051	0.409186	0	1.41822729000303	0.409377	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0045296,cadherin binding;GO:0003937,IMP cyclohydrolase activity;GO:0004643,phosphoribosylaminoimidazolecarboxamide formyltransferase activity;GO:0042803,protein homodimerization activity	GO:0006189,'de novo' IMP biosynthetic process;GO:0031100,animal organ regeneration;GO:0003360,brainstem development;GO:0098761,cellular response to interleukin-7;GO:0021549,cerebellum development;GO:0021987,cerebral cortex development;GO:0046452,dihydrofolate metabolic process;GO:0006139,nucleobase-containing compound metabolic process;GO:0009116,nucleoside metabolic process;GO:0009168,purine ribonucleoside monophosphate biosynthetic process;GO:0010035,response to inorganic substance;GO:0046654,tetrahydrofolate biosynthetic process;GO:0006164,purine nucleotide biosynthetic process	hsa:471,path:hsa00230,Purine metabolism;hsa:471,path:hsa00670,One carbon pool by folate;hsa:471,path:hsa01523,Antifolate resistance
NUD19_HUMAN	A8MXV4	NUDT19	Nucleoside diphosphate-linked moiety X motif 19	0.184008134	0.121389605	0.286895526	0.368472944	0.1526988695	0.327684235	0.1526988695	0.327684235	0.465993945360234	0.194182	0	2.14595062866526	0.194517	0	GO:0005829,cytosol;GO:0005782,peroxisomal matrix	GO:0016787,hydrolase activity;GO:0046872,metal ion binding	GO:0009062,fatty acid catabolic process;GO:0008104,protein localization	hsa:390916,path:hsa04146,Peroxisome
MUC4_HUMAN	Q99102	MUC4	Mucin-4	0.04243321	0.096887758	0.102190767	2.55E-05	0.069660484	0.0511081335	0.069660484	0.0511081335	1.36300191827588	0.334007	0	0.733674682765627	0.333613	0	GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005615,extracellular space;GO:0005796,Golgi lumen;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0031982,vesicle;GO:0016021,integral component of membrane	GO:0005176,ErbB-2 class receptor binding;GO:0030197,extracellular matrix constituent, lubricant activity	GO:0007160,cell-matrix adhesion;GO:0030277,maintenance of gastrointestinal epithelium;GO:0016266,O-glycan processing;GO:0010469,regulation of signaling receptor activity;GO:0002223,stimulatory C-type lectin receptor signaling pathway	
SRP54_HUMAN	P61011	SRP54	Signal recognition particle 54 kDa protein	1.355959257	0.266048355	1.056840287	0.773628621	0.811003806	0.915234454	0.811003806	0.915234454	0.886115904460913	0.473713	0	1.12852054112308	0.473604	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0016607,nuclear speck;GO:0005634,nucleus;GO:0005786,signal recognition particle, endoplasmic reticulum targeting;GO:0048500,signal recognition particle	GO:0008312,7S RNA binding;GO:0030942,endoplasmic reticulum signal peptide binding;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0043021,ribonucleoprotein complex binding;GO:0003723,RNA binding	GO:0031017,exocrine pancreas development;GO:0030851,granulocyte differentiation;GO:0030593,neutrophil chemotaxis;GO:0045047,protein targeting to ER;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006617,SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition;GO:0006616,SRP-dependent cotranslational protein targeting to membrane, translocation	hsa:6729,path:hsa03060,Protein export
5NTD_HUMAN	P21589	NT5E	5'-nucleotidase	0.083033487	0.096182339	0.155385076	0.818956727	0.089607913	0.4871709015	0.089607913	0.4871709015	0.183935273482257	0.011209	-1	5.43669509968389	0.011293	1	GO:0031225,anchored component of membrane;GO:0009986,cell surface;GO:0005829,cytosol;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0008253,5'-nucleotidase activity;GO:0046872,metal ion binding;GO:0000166,nucleotide binding;GO:0016787,hydrolase activity	GO:0046086,adenosine biosynthetic process;GO:0046032,ADP catabolic process;GO:0006196,AMP catabolic process;GO:0006259,DNA metabolic process;GO:0007159,leukocyte cell-cell adhesion;GO:0019674,NAD metabolic process;GO:0050728,negative regulation of inflammatory response;GO:0006195,purine nucleotide catabolic process;GO:0035590,purinergic nucleotide receptor signaling pathway;GO:0046135,pyrimidine nucleoside catabolic process;GO:0009166,nucleotide catabolic process	hsa:4907,path:hsa00230,Purine metabolism;hsa:4907,path:hsa00240,Pyrimidine metabolism;hsa:4907,path:hsa00760,Nicotinate and nicotinamide metabolism
IDH3G_HUMAN	P51553	IDH3G	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	0.892982799	0.191883894	0.625508984	0.186877264	0.5424333465	0.406193124	0.5424333465	0.406193124	1.33540750556871	0.340303	0	0.748835090285144	0.339920	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005730,nucleolus	GO:0005524,ATP binding;GO:0004449,isocitrate dehydrogenase (NAD+) activity;GO:0000287,magnesium ion binding;GO:0051287,NAD binding;GO:0016616,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO:0005975,carbohydrate metabolic process;GO:0006102,isocitrate metabolic process;GO:0006099,tricarboxylic acid cycle	hsa:3421,path:hsa00020,Citrate cycle (TCA cycle)
DYN2_HUMAN	P50570	DNM2	Dynamin-2	6.058167115	6.816600523	7.172140527	15.36679311	6.437383819	11.2694668185	6.437383819	11.2694668185	0.571223459164223	0.290669	0	1.75062838186501	0.290964	0	GO:0030424,axon;GO:0005813,centrosome;GO:0045334,clathrin-coated endocytic vesicle;GO:0005905,clathrin-coated pit;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0044327,dendritic spine head;GO:0030666,endocytic vesicle membrane;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0030426,growth cone;GO:0030027,lamellipodium;GO:0016020,membrane;GO:0005874,microtubule;GO:0015630,microtubule cytoskeleton;GO:0030496,midbody;GO:0031966,mitochondrial membrane;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0001891,phagocytic cup;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0099092,postsynaptic density, intracellular component;GO:0098844,postsynaptic endocytic zone membrane;GO:0045211,postsynaptic membrane;GO:0098793,presynapse;GO:0032991,protein-containing complex;GO:0032587,ruffle membrane;GO:0005802,trans-Golgi network	GO:0031749,D2 dopamine receptor binding;GO:0019899,enzyme binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0008017,microtubule binding;GO:0050998,nitric-oxide synthase binding;GO:0036312,phosphatidylinositol 3-kinase regulatory subunit binding;GO:0019901,protein kinase binding;GO:0044877,protein-containing complex binding;GO:0017124,SH3 domain binding;GO:0050699,WW domain binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0071245,cellular response to carbon monoxide;GO:1903351,cellular response to dopamine;GO:0071732,cellular response to nitric oxide;GO:0071481,cellular response to X-ray;GO:0003374,dynamin family protein polymerization involved in mitochondrial fission;GO:0006897,endocytosis;GO:0002031,G protein-coupled receptor internalization;GO:0000086,G2/M transition of mitotic cell cycle;GO:0006893,Golgi to plasma membrane transport;GO:0044351,macropinocytosis;GO:0061025,membrane fusion;GO:0061024,membrane organization;GO:0000266,mitochondrial fission;GO:1903526,negative regulation of membrane tubulation;GO:1902856,negative regulation of non-motile cilium assembly;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0048812,neuron projection morphogenesis;GO:0006909,phagocytosis;GO:0043065,positive regulation of apoptotic process;GO:2000370,positive regulation of clathrin-dependent endocytosis;GO:0010592,positive regulation of lamellipodium assembly;GO:0045429,positive regulation of nitric oxide biosynthetic process;GO:1903408,positive regulation of P-type sodium;GO:0050766,positive regulation of phagocytosis;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0045893,positive regulation of transcription, DNA-templated;GO:0006892,post-Golgi vesicle-mediated transport;GO:0098884,postsynaptic neurotransmitter receptor internalization;GO:0031623,receptor internalization;GO:0006898,receptor-mediated endocytosis;GO:0030516,regulation of axon extension;GO:1903358,regulation of Golgi organization;GO:0050999,regulation of nitric-oxide synthase activity;GO:0035020,regulation of Rac protein signal transduction;GO:0050803,regulation of synapse structure or activity;GO:0006355,regulation of transcription, DNA-templated;GO:0042220,response to cocaine;GO:0009416,response to light stimulus;GO:0007165,signal transduction;GO:0007283,spermatogenesis;GO:0016185,synaptic vesicle budding from presynaptic endocytic zone membrane;GO:0048489,synaptic vesicle transport;GO:0033572,transferrin transport	hsa:1785,path:hsa04072,Phospholipase D signaling pathway;hsa:1785,path:hsa04144,Endocytosis;hsa:1785,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:1785,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:1785,path:hsa04721,Synaptic vesicle cycle;hsa:1785,path:hsa05132,Salmonella infection;hsa:1785,path:hsa05100,Bacterial invasion of epithelial cells
MIC19_HUMAN	Q9NX63	CHCHD3	MICOS complex subunit MIC19	1.247027551	1.207673744	1.357506708	1.719470694	1.2273506475	1.538488701	1.2273506475	1.538488701	0.797763835835932	0.483664	0	1.25350380034732	0.483774	0	GO:0070062,extracellular exosome;GO:0140275,MIB complex;GO:0061617,MICOS complex;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0001401,SAM complex;GO:0016021,integral component of membrane	GO:0060090,molecular adaptor activity;GO:0019902,phosphatase binding	GO:0042407,cristae formation;GO:0007007,inner mitochondrial membrane organization;GO:0008053,mitochondrial fusion	
CTNB1_HUMAN	P35222	CTNNB1	Catenin beta-1	3.457527609	2.762338262	3.591475678	6.131093162	3.1099329355	4.86128442	3.1099329355	4.86128442	0.639734824546637	0.352594	0	1.56314766936234	0.352840	0	GO:0005912,adherens junction;GO:0016323,basolateral plasma membrane;GO:0030877,beta-catenin destruction complex;GO:1990907,beta-catenin-TCF complex;GO:0070369,beta-catenin-TCF7L2 complex;GO:0016342,catenin complex;GO:0005938,cell cortex;GO:0030054,cell junction;GO:0071944,cell periphery;GO:0042995,cell projection;GO:0005911,cell-cell junction;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0000791,euchromatin;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016328,lateral plasma membrane;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0032993,protein-DNA complex;GO:0000922,spindle pole;GO:0045202,synapse;GO:0005667,transcription regulator complex;GO:1990909,Wnt signalosome;GO:0045177,apical part of cell;GO:0016327,apicolateral plasma membrane;GO:0005923,bicellular tight junction;GO:0005916,fascia adherens;GO:0016600,flotillin complex;GO:0030027,lamellipodium;GO:0031528,microvillus membrane;GO:0099092,postsynaptic density, intracellular component;GO:0045211,postsynaptic membrane;GO:0098831,presynaptic active zone cytoplasmic component;GO:0042734,presynaptic membrane;GO:0098685,Schaffer collateral - CA1 synapse;GO:0034750,Scrib-APC-beta-catenin complex;GO:0030018,Z disc	GO:0045294,alpha-catenin binding;GO:0008013,beta-catenin binding;GO:0045296,cadherin binding;GO:0003682,chromatin binding;GO:0140297,DNA-binding transcription factor binding;GO:0019899,enzyme binding;GO:0030331,estrogen receptor binding;GO:1990226,histone methyltransferase binding;GO:0070411,I-SMAD binding;GO:0044325,ion channel binding;GO:0019900,kinase binding;GO:0035257,nuclear hormone receptor binding;GO:0008022,protein C-terminus binding;GO:0019903,protein phosphatase binding;GO:0001102,RNA polymerase II activating transcription factor binding;GO:0001085,RNA polymerase II transcription factor binding;GO:0046332,SMAD binding;GO:0003713,transcription coactivator activity;GO:0001221,transcription coregulator binding;GO:0008134,transcription factor binding;GO:0097718,disordered domain specific binding;GO:0019901,protein kinase binding;GO:0070491,repressing transcription factor binding	GO:0034333,adherens junction assembly;GO:1904886,beta-catenin destruction complex disassembly;GO:1904837,beta-catenin-TCF complex assembly;GO:0001569,branching involved in blood vessel morphogenesis;GO:0060070,canonical Wnt signaling pathway;GO:1904954,canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation;GO:0044336,canonical Wnt signaling pathway involved in negative regulation of apoptotic process;GO:0061324,canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation;GO:0044334,canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition;GO:0007155,cell adhesion;GO:0098609,cell-cell adhesion;GO:0071363,cellular response to growth factor stimulus;GO:0071681,cellular response to indole-3-methanol;GO:0035995,detection of muscle stretch;GO:0036023,embryonic skeletal limb joint morphogenesis;GO:0061154,endothelial tube morphogenesis;GO:0035635,entry of bacterium into host cell;GO:0001837,epithelial to mesenchymal transition;GO:0035315,hair cell differentiation;GO:1904948,midbrain dopaminergic neuron differentiation;GO:0016525,negative regulation of angiogenesis;GO:0043066,negative regulation of apoptotic process;GO:0008285,negative regulation of cell population proliferation;GO:0045976,negative regulation of mitotic cell cycle, embryonic;GO:0033234,negative regulation of protein sumoylation;GO:0045892,negative regulation of transcription, DNA-templated;GO:1990138,neuron projection extension;GO:0043065,positive regulation of apoptotic process;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0010718,positive regulation of epithelial to mesenchymal transition;GO:0010909,positive regulation of heparan sulfate proteoglycan biosynthetic process;GO:0051571,positive regulation of histone H3-K4 methylation;GO:0051149,positive regulation of muscle cell differentiation;GO:0002052,positive regulation of neuroblast proliferation;GO:0043525,positive regulation of neuron apoptotic process;GO:0051973,positive regulation of telomerase activity;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0032481,positive regulation of type I interferon production;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0034394,protein localization to cell surface;GO:0000209,protein polyubiquitination;GO:0045765,regulation of angiogenesis;GO:0090279,regulation of calcium ion import;GO:0060828,regulation of canonical Wnt signaling pathway;GO:0030997,regulation of centriole-centriole cohesion;GO:0070602,regulation of centromeric sister chromatid cohesion;GO:0048145,regulation of fibroblast proliferation;GO:0072182,regulation of nephron tubule epithelial cell differentiation;GO:0050767,regulation of neurogenesis;GO:2000008,regulation of protein localization to cell surface;GO:0048660,regulation of smooth muscle cell proliferation;GO:0060260,regulation of transcription initiation from RNA polymerase II promoter;GO:0042493,response to drug;GO:0032355,response to estradiol;GO:0019827,stem cell population maintenance;GO:0061549,sympathetic ganglion development;GO:0016032,viral process;GO:0016055,Wnt signaling pathway;GO:0007223,Wnt signaling pathway, calcium modulating pathway;GO:0034332,adherens junction organization;GO:0009948,anterior/posterior axis specification;GO:0036520,astrocyte-dopaminergic neuron signaling;GO:0045453,bone resorption;GO:0001658,branching involved in ureteric bud morphogenesis;GO:0044338,canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation;GO:0001708,cell fate specification;GO:0048469,cell maturation;GO:0000904,cell morphogenesis involved in differentiation;GO:0007160,cell-matrix adhesion;GO:0034613,cellular protein localization;GO:0022009,central nervous system vasculogenesis;GO:0007268,chemical synaptic transmission;GO:0061550,cranial ganglion development;GO:1904888,cranial skeletal system development;GO:1990791,dorsal root ganglion development;GO:0009950,dorsal/ventral axis specification;GO:0007398,ectoderm development;GO:0000578,embryonic axis specification;GO:1990403,embryonic brain development;GO:0042733,embryonic digit morphogenesis;GO:0048617,embryonic foregut morphogenesis;GO:0035115,embryonic forelimb morphogenesis;GO:0035050,embryonic heart tube development;GO:0035116,embryonic hindlimb morphogenesis;GO:0001711,endodermal cell fate commitment;GO:0060742,epithelial cell differentiation involved in prostate gland development;GO:0060441,epithelial tube branching involved in lung morphogenesis;GO:0061198,fungiform papilla formation;GO:0001702,gastrulation with mouth forming second;GO:0035112,genitalia morphogenesis;GO:0007403,glial cell fate determination;GO:0031069,hair follicle morphogenesis;GO:0060789,hair follicle placode formation;GO:0030902,hindbrain development;GO:0001701,in utero embryonic development;GO:0021819,layer formation in cerebral cortex;GO:0002089,lens morphogenesis in camera-type eye;GO:0060479,lung cell differentiation;GO:0060492,lung induction;GO:0060484,lung-associated mesenchyme development;GO:0030539,male genitalia development;GO:0060916,mesenchymal cell proliferation involved in lung development;GO:0003338,metanephros morphogenesis;GO:2001234,negative regulation of apoptotic signaling pathway;GO:0032331,negative regulation of chondrocyte differentiation;GO:0010629,negative regulation of gene expression;GO:0003340,negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0048715,negative regulation of oligodendrocyte differentiation;GO:0045671,negative regulation of osteoclast differentiation;GO:1903204,negative regulation of oxidative stress-induced neuron death;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0072079,nephron tubule formation;GO:0001840,neural plate development;GO:0001764,neuron migration;GO:0042475,odontogenesis of dentin-containing tooth;GO:0048599,oocyte development;GO:0030316,osteoclast differentiation;GO:0060066,oviduct development;GO:0031016,pancreas development;GO:0061047,positive regulation of branching involved in lung morphogenesis;GO:1904798,positive regulation of core promoter binding;GO:2000017,positive regulation of determination of dorsal identity;GO:0045603,positive regulation of endothelial cell differentiation;GO:0060769,positive regulation of epithelial cell proliferation involved in prostate gland development;GO:0045743,positive regulation of fibroblast growth factor receptor signaling pathway;GO:0010628,positive regulation of gene expression;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043410,positive regulation of MAPK cascade;GO:0002053,positive regulation of mesenchymal cell proliferation;GO:0045669,positive regulation of osteoblast differentiation;GO:0048643,positive regulation of skeletal muscle tissue development;GO:0032968,positive regulation of transcription elongation from RNA polymerase II promoter;GO:0009954,proximal/distal pattern formation;GO:0031641,regulation of myelination;GO:0003266,regulation of secondary heart field cardioblast proliferation;GO:0042129,regulation of T cell proliferation;GO:0051884,regulation of timing of anagen;GO:0072053,renal inner medulla development;GO:0072054,renal outer medulla development;GO:0072033,renal vesicle formation;GO:0051145,smooth muscle cell differentiation;GO:0050808,synapse organization;GO:0097091,synaptic vesicle clustering;GO:0048489,synaptic vesicle transport;GO:0033077,T cell differentiation in thymus;GO:0048538,thymus development;GO:0060440,trachea formation	hsa:1499,path:hsa04015,Rap1 signaling pathway;hsa:1499,path:hsa04310,Wnt signaling pathway;hsa:1499,path:hsa04390,Hippo signaling pathway;hsa:1499,path:hsa04510,Focal adhesion;hsa:1499,path:hsa04520,Adherens junction;hsa:1499,path:hsa04550,Signaling pathways regulating pluripotency of stem cells;hsa:1499,path:hsa04670,Leukocyte transendothelial migration;hsa:1499,path:hsa04919,Thyroid hormone signaling pathway;hsa:1499,path:hsa04916,Melanogenesis;hsa:1499,path:hsa05200,Pathways in cancer;hsa:1499,path:hsa05205,Proteoglycans in cancer;hsa:1499,path:hsa05210,Colorectal cancer;hsa:1499,path:hsa05225,Hepatocellular carcinoma;hsa:1499,path:hsa05226,Gastric cancer;hsa:1499,path:hsa05216,Thyroid cancer;hsa:1499,path:hsa05217,Basal cell carcinoma;hsa:1499,path:hsa05215,Prostate cancer;hsa:1499,path:hsa05213,Endometrial cancer;hsa:1499,path:hsa05224,Breast cancer;hsa:1499,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:1499,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:1499,path:hsa04934,Cushing syndrome;hsa:1499,path:hsa05132,Salmonella infection;hsa:1499,path:hsa05100,Bacterial invasion of epithelial cells;hsa:1499,path:hsa05160,Hepatitis C;hsa:1499,path:hsa05163,Human cytomegalovirus infection;hsa:1499,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:1499,path:hsa05165,Human papillomavirus infection
LEG7_HUMAN	P47929	LGALS7	Galectin-7	2.323115204	3.903433123	0.451743964	0.402182043	3.1132741635	0.4269630035	3.1132741635	0.4269630035	7.29167196684291	0.032709	1	0.13714275745635	0.032400	-1	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005634,nucleus	GO:0030246,carbohydrate binding;GO:0016936,galactoside binding	GO:0006915,apoptotic process;GO:0007157,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:2000562,negative regulation of CD4-positive, alpha-beta T cell proliferation;GO:0032689,negative regulation of interferon-gamma production;GO:0010628,positive regulation of gene expression	
SF3B4_HUMAN	Q15427	SF3B4	Splicing factor 3B subunit 4	0.104353689	2.55E-05	0.329094863	2.55E-05	0.0521895945	0.1645601815	0.0521895945	0.1645601815	0.31714594639044	0.073437	0	3.153122438995	0.073701	0	GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0005689,U12-type spliceosomal complex;GO:0071005,U2-type precatalytic spliceosome	GO:0003723,RNA binding;GO:1990935,splicing factor binding	GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0048026,positive regulation of mRNA splicing, via spliceosome;GO:0008380,RNA splicing;GO:0000375,RNA splicing, via transesterification reactions	hsa:10262,path:hsa03040,Spliceosome
ASCC2_HUMAN	Q9H1I8	ASCC2	Activating signal cointegrator 1 complex subunit 2	0.018901407	0.013078942	0.030722866	2.55E-05	0.0159901745	0.015374183	0.0159901745	0.015374183	1.04006661687323	0.420365	0	0.961476874439363	0.420140	0	GO:0099053,activating signal cointegrator 1 complex;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0043130,ubiquitin binding	GO:0006307,DNA dealkylation involved in DNA repair;GO:0006355,regulation of transcription, DNA-templated	
RL22_HUMAN	P35268	RPL22	60S ribosomal protein L22	8.025622582	12.69422636	2.397758263	1.86792836	10.359924471	2.1328433115	10.359924471	2.1328433115	4.85733031354938	0.066809	0	0.205874407431286	0.066360	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0005634,nucleus;GO:0098793,presynapse;GO:1990904,ribonucleoprotein complex;GO:0005840,ribosome	GO:0008201,heparin binding;GO:0042802,identical protein binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome;GO:0045182,translation regulator activity	GO:0046632,alpha-beta T cell differentiation;GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0099577,regulation of translation at presynapse, modulating synaptic transmission;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6146,path:hsa03010,Ribosome
TBCD_HUMAN	Q9BTW9	TBCD	Tubulin-specific chaperone D	0.559993475	0.315568686	0.889242603	0.155453016	0.4377810805	0.5223478095	0.4377810805	0.5223478095	0.838102644517742	0.492426	0	1.19317127387829	0.492359	0	GO:0005912,adherens junction;GO:0005923,bicellular tight junction;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0016328,lateral plasma membrane;GO:0005874,microtubule	GO:0048487,beta-tubulin binding;GO:0051087,chaperone binding;GO:0005096,GTPase activator activity	GO:0034333,adherens junction assembly;GO:0070830,bicellular tight junction assembly;GO:0048667,cell morphogenesis involved in neuron differentiation;GO:0000226,microtubule cytoskeleton organization;GO:0000278,mitotic cell cycle;GO:0010812,negative regulation of cell-substrate adhesion;GO:0031115,negative regulation of microtubule polymerization;GO:0007023,post-chaperonin tubulin folding pathway;GO:0006457,protein folding;GO:0007021,tubulin complex assembly;GO:0043547,positive regulation of GTPase activity	
ISG20_HUMAN	Q96AZ6	ISG20	Interferon-stimulated gene 20 kDa protein	0.285982228	0.325094242	0.018130207	0.005261633	0.305538235	0.01169592	0.305538235	0.01169592	26.123488789253	0.001762	1	0.0382797262673197	0.001724	-1	GO:0015030,Cajal body;GO:0005737,cytoplasm;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016605,PML body	GO:0000175,3'-5'-exoribonuclease activity;GO:0004527,exonuclease activity;GO:0008859,exoribonuclease II activity;GO:0046872,metal ion binding;GO:0008310,single-stranded DNA 3'-5' exodeoxyribonuclease activity;GO:0030619,U1 snRNA binding;GO:0030620,U2 snRNA binding;GO:0034511,U3 snoRNA binding;GO:0003676,nucleic acid binding	GO:0051607,defense response to virus;GO:0000738,DNA catabolic process, exonucleolytic;GO:0045071,negative regulation of viral genome replication;GO:0009615,response to virus;GO:0006401,RNA catabolic process;GO:0006364,rRNA processing;GO:0060337,type I interferon signaling pathway	
SC23A_HUMAN	Q15436	SEC23A	Protein transport protein Sec23A	3.963295904	3.574720613	4.488545342	4.77249875	3.7690082585	4.630522046	3.7690082585	4.630522046	0.813948885473031	0.495905	0	1.2285783761702	0.496000	0	GO:0030127,COPII vesicle coat;GO:0005829,cytosol;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0019898,extrinsic component of membrane;GO:0000139,Golgi membrane;GO:0048471,perinuclear region of cytoplasm	GO:0005096,GTPase activator activity;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0048208,COPII vesicle coating;GO:0090110,COPII-coated vesicle cargo loading;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0072659,protein localization to plasma membrane;GO:0090114,COPII-coated vesicle budding;GO:0015031,protein transport;GO:0016192,vesicle-mediated transport	hsa:10484,path:hsa04141,Protein processing in endoplasmic reticulum
DYSF_HUMAN	O75923	DYSF	Dysferlin	2.945373493	0.451027329	2.010730953	4.415369155	1.698200411	3.213050054	1.698200411	3.213050054	0.528532199143885	0.251385	0	1.89203231443571	0.251703	0	GO:0034451,centriolar satellite;GO:0031410,cytoplasmic vesicle;GO:0030659,cytoplasmic vesicle membrane;GO:0005769,early endosome;GO:0030139,endocytic vesicle;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005770,late endosome;GO:0005886,plasma membrane;GO:0042383,sarcolemma;GO:0030315,T-tubule	GO:0005509,calcium ion binding;GO:0005544,calcium-dependent phospholipid binding;GO:0005543,phospholipid binding	GO:0002281,macrophage activation involved in immune response;GO:0061025,membrane fusion;GO:0002280,monocyte activation involved in immune response;GO:0006936,muscle contraction;GO:0050765,negative regulation of phagocytosis;GO:0007009,plasma membrane organization;GO:0001778,plasma membrane repair;GO:0033292,T-tubule organization;GO:0006906,vesicle fusion	
SARNP_HUMAN	P82979	SARNP	SAP domain-containing ribonucleoprotein	0.37423586	0.647475416	0.226771048	0.062021848	0.510855638	0.144396448	0.510855638	0.144396448	3.53786845227661	0.108820	0	0.282656072007568	0.108284	0	GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000346,transcription export complex	GO:0003677,DNA binding;GO:0003723,RNA binding;GO:0003682,chromatin binding	GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0016973,poly(A)+ mRNA export from nucleus;GO:0006417,regulation of translation;GO:0006405,RNA export from nucleus;GO:0000122,negative regulation of transcription by RNA polymerase II	
RHOG_HUMAN	P84095	RHOG	Rho-related GTP-binding protein RhoG	2.619140478	6.442111723	0.698974344	2.396166612	4.5306261005	1.547570478	4.5306261005	1.547570478	2.92757335766391	0.141584	0	0.341579826644536	0.141019	0	GO:0005938,cell cortex;GO:0042995,cell projection;GO:0031410,cytoplasmic vesicle;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0043231,intracellular membrane-bounded organelle;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0019901,protein kinase binding	GO:0030036,actin cytoskeleton organization;GO:0007015,actin filament organization;GO:0090630,activation of GTPase activity;GO:0060326,cell chemotaxis;GO:0030031,cell projection assembly;GO:0030865,cortical cytoskeleton organization;GO:0043652,engulfment of apoptotic cell;GO:0007163,establishment or maintenance of cell polarity;GO:0008045,motor neuron axon guidance;GO:0043312,neutrophil degranulation;GO:0008284,positive regulation of cell population proliferation;GO:0051897,positive regulation of protein kinase B signaling;GO:1903078,positive regulation of protein localization to plasma membrane;GO:0045893,positive regulation of transcription, DNA-templated;GO:0016601,Rac protein signal transduction;GO:0032956,regulation of actin cytoskeleton organization;GO:0008360,regulation of cell shape;GO:1902622,regulation of neutrophil migration;GO:1900027,regulation of ruffle assembly;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007266,Rho protein signal transduction	hsa:391,path:hsa05132,Salmonella infection;hsa:391,path:hsa05100,Bacterial invasion of epithelial cells
LSS_HUMAN	P48449	LSS	Lanosterol synthase	1.050859013	0.621914517	4.23477007	1.746782398	0.836386765	2.990776234	0.836386765	2.990776234	0.279655413698864	0.050200	0	3.57582922058792	0.050419	0	GO:0005789,endoplasmic reticulum membrane;GO:0005811,lipid droplet;GO:0016020,membrane	GO:0042300,beta-amyrin synthase activity;GO:0000250,lanosterol synthase activity	GO:0006695,cholesterol biosynthetic process;GO:0019216,regulation of lipid metabolic process;GO:0031647,regulation of protein stability;GO:0006694,steroid biosynthetic process;GO:0016104,triterpenoid biosynthetic process	hsa:4047,path:hsa00100,Steroid biosynthesis
LRC40_HUMAN	Q9H9A6	LRRC40	Leucine-rich repeat-containing protein 40	0.447725353	0.268689661	0.437961592	0.871380487	0.358207507	0.6546710395	0.358207507	0.6546710395	0.547156488354179	0.268546	0	1.82763070763897	0.268855	0	GO:0005737,cytoplasm;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane	GO:0004722,protein serine/threonine phosphatase activity	GO:0007165,signal transduction	
CCAR1_HUMAN	Q8IX12	CCAR1	Cell division cycle and apoptosis regulator protein 1	1.639292466	0.748899944	1.150846373	1.310188621	1.194096205	1.230517497	1.194096205	1.230517497	0.970401646389592	0.443333	0	1.03050113705034	0.443158	0	GO:0005641,nuclear envelope lumen;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005737,cytoplasm	GO:0030374,nuclear receptor coactivator activity;GO:0003723,RNA binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003713,transcription coactivator activity;GO:0003714,transcription corepressor activity	GO:0006915,apoptotic process;GO:0007049,cell cycle;GO:0000398,mRNA splicing, via spliceosome;GO:0043065,positive regulation of apoptotic process;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0006355,regulation of transcription, DNA-templated	
TMED9_HUMAN	Q9BVK6	TMED9	Transmembrane emp24 domain-containing protein 9	5.061466726	14.18460349	2.869882918	1.411018488	9.623035108	2.140450703	9.623035108	2.140450703	4.49579852248529	0.075673	0	0.222429896490823	0.075200	0	GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0008021,synaptic vesicle;GO:0030140,trans-Golgi network transport vesicle;GO:0030133,transport vesicle	GO:0019905,syntaxin binding	GO:0048205,COPI coating of Golgi vesicle;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030,Golgi organization;GO:0006886,intracellular protein transport;GO:0010638,positive regulation of organelle organization;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	
TRADD_HUMAN	Q15628	TRADD	Tumor necrosis factor receptor type 1-associated DEATH domain protein	0.181654842	0.034023021	0.209736871	2.55E-05	0.1078389315	0.1048811855	0.1078389315	0.1048811855	1.02820092074569	0.424150	0	0.97257255836219	0.423933	0	GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0031264,death-inducing signaling complex;GO:0045121,membrane raft;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0043235,receptor complex;GO:0002947,tumor necrosis factor receptor superfamily complex	GO:0070513,death domain binding;GO:0042802,identical protein binding;GO:0019900,kinase binding;GO:0044877,protein-containing complex binding;GO:0005068,transmembrane receptor protein tyrosine kinase adaptor activity;GO:0005164,tumor necrosis factor receptor binding	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006915,apoptotic process;GO:0071356,cellular response to tumor necrosis factor;GO:0071550,death-inducing signaling complex assembly;GO:0097191,extrinsic apoptotic signaling pathway;GO:0008625,extrinsic apoptotic signaling pathway via death domain receptors;GO:0007249,I-kappaB kinase/NF-kappaB signaling;GO:1902042,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0043065,positive regulation of apoptotic process;GO:0030335,positive regulation of cell migration;GO:0051798,positive regulation of hair follicle development;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0050729,positive regulation of inflammatory response;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:1902041,regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0010803,regulation of tumor necrosis factor-mediated signaling pathway;GO:0007165,signal transduction;GO:0033209,tumor necrosis factor-mediated signaling pathway	hsa:8717,path:hsa04010,MAPK signaling pathway;hsa:8717,path:hsa04064,NF-kappa B signaling pathway;hsa:8717,path:hsa04668,TNF signaling pathway;hsa:8717,path:hsa04071,Sphingolipid signaling pathway;hsa:8717,path:hsa04210,Apoptosis;hsa:8717,path:hsa04217,Necroptosis;hsa:8717,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:8717,path:hsa04657,IL-17 signaling pathway;hsa:8717,path:hsa04920,Adipocytokine signaling pathway;hsa:8717,path:hsa05203,Viral carcinogenesis;hsa:8717,path:hsa05130,Pathogenic Escherichia coli infection;hsa:8717,path:hsa05132,Salmonella infection;hsa:8717,path:hsa05131,Shigellosis;hsa:8717,path:hsa05152,Tuberculosis;hsa:8717,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:8717,path:hsa05162,Measles;hsa:8717,path:hsa05164,Influenza A;hsa:8717,path:hsa05160,Hepatitis C;hsa:8717,path:hsa05168,Herpes simplex virus 1 infection;hsa:8717,path:hsa05163,Human cytomegalovirus infection;hsa:8717,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:8717,path:hsa05169,Epstein-Barr virus infection;hsa:8717,path:hsa05165,Human papillomavirus infection
BIP_HUMAN	P11021	HSPA5	Endoplasmic reticulum chaperone BiP	132.9889249	93.85540595	138.9939895	117.3755832	113.422165425	128.18478635	113.422165425	128.18478635	0.884833283688661	0.474199	0	1.13015640170229	0.474091	0	GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0034663,endoplasmic reticulum chaperone complex;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0042470,melanosome;GO:0016020,membrane;GO:0030496,midbody;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0005790,smooth endoplasmic reticulum	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0045296,cadherin binding;GO:0005509,calcium ion binding;GO:0051087,chaperone binding;GO:0019899,enzyme binding;GO:0031072,heat shock protein binding;GO:0051787,misfolded protein binding;GO:0019904,protein domain specific binding;GO:0044183,protein folding chaperone;GO:0043022,ribosome binding;GO:0031625,ubiquitin protein ligase binding;GO:0051082,unfolded protein binding	GO:0036500,ATF6-mediated unfolded protein response;GO:0071236,cellular response to antibiotic;GO:0071277,cellular response to calcium ion;GO:0071320,cellular response to cAMP;GO:0035690,cellular response to drug;GO:0071480,cellular response to gamma radiation;GO:0042149,cellular response to glucose starvation;GO:0071353,cellular response to interleukin-4;GO:0071287,cellular response to manganese ion;GO:1990090,cellular response to nerve growth factor stimulus;GO:0034620,cellular response to unfolded protein;GO:0021680,cerebellar Purkinje cell layer development;GO:0021589,cerebellum structural organization;GO:0051085,chaperone cofactor-dependent protein refolding;GO:0030968,endoplasmic reticulum unfolded protein response;GO:0006983,ER overload response;GO:0036498,IRE1-mediated unfolded protein response;GO:0001554,luteolysis;GO:0035437,maintenance of protein localization in endoplasmic reticulum;GO:0043066,negative regulation of apoptotic process;GO:1903895,negative regulation of IRE1-mediated unfolded protein response;GO:0031333,negative regulation of protein-containing complex assembly;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0051402,neuron apoptotic process;GO:0030182,neuron differentiation;GO:0036499,PERK-mediated unfolded protein response;GO:0030335,positive regulation of cell migration;GO:0010976,positive regulation of neuron projection development;GO:0031398,positive regulation of protein ubiquitination;GO:1990440,positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:0031204,posttranslational protein targeting to membrane, translocation;GO:0034975,protein folding in endoplasmic reticulum;GO:0042026,protein refolding;GO:1903891,regulation of ATF6-mediated unfolded protein response;GO:1903894,regulation of IRE1-mediated unfolded protein response;GO:1903897,regulation of PERK-mediated unfolded protein response;GO:0060904,regulation of protein folding in endoplasmic reticulum;GO:0042220,response to cocaine;GO:1904313,response to methamphetamine hydrochloride;GO:0097501,stress response to metal ion;GO:0021762,substantia nigra development;GO:1901998,toxin transport;GO:0030433,ubiquitin-dependent ERAD pathway	hsa:3309,path:hsa03060,Protein export;hsa:3309,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:3309,path:hsa04612,Antigen processing and presentation;hsa:3309,path:hsa04918,Thyroid hormone synthesis;hsa:3309,path:hsa05020,Prion diseases
AL1A1_HUMAN	P00352	ALDH1A1	Retinal dehydrogenase 1	8.303457942	21.44363125	32.96931948	60.08653543	14.873544596	46.527927455	14.873544596	46.527927455	0.319669183854903	0.075139	0	3.1282339696963	0.075406	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0004029,aldehyde dehydrogenase (NAD+) activity;GO:0005497,androgen binding;GO:0018479,benzaldehyde dehydrogenase (NAD+) activity;GO:0005096,GTPase activator activity;GO:0051287,NAD binding;GO:0001758,retinal dehydrogenase activity;GO:0016491,oxidoreductase activity	GO:0006081,cellular aldehyde metabolic process;GO:0006069,ethanol oxidation;GO:0061624,fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate;GO:0120163,negative regulation of cold-induced thermogenesis;GO:0001523,retinoid metabolic process;GO:0042572,retinol metabolic process	hsa:216,path:hsa00830,Retinol metabolism
JAGN1_HUMAN	Q8N5M9	JAGN1	Protein jagunal homolog 1	0.318223003	2.55E-05	0.048776989	2.55E-05	0.1591242515	0.0244012445	0.1591242515	0.0244012445	6.52115311167838	0.040209	1	0.153347112523574	0.039862	-1	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane		GO:1904577,cellular response to tunicamycin;GO:0050832,defense response to fungus;GO:0007029,endoplasmic reticulum organization;GO:0006887,exocytosis;GO:0038158,granulocyte colony-stimulating factor signaling pathway;GO:0061179,negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0030223,neutrophil differentiation;GO:0002446,neutrophil mediated immunity;GO:1990266,neutrophil migration;GO:0015031,protein transport;GO:0016192,vesicle-mediated transport	
STX4_HUMAN	Q12846	STX4	Syntaxin-4	0.292286737	0.276135513	0.281679679	0.362743375	0.284211125	0.322211527	0.284211125	0.322211527	0.882063803384663	0.475251	0	1.13370483650139	0.475146	0	GO:0016323,basolateral plasma membrane;GO:0009986,cell surface;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0012505,endomembrane system;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0098978,glutamatergic synapse;GO:0016021,integral component of membrane;GO:0030027,lamellipodium;GO:0043219,lateral loop;GO:0016020,membrane;GO:0035749,myelin sheath adaxonal region;GO:0048471,perinuclear region of cytoplasm;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0098794,postsynapse;GO:0048787,presynaptic active zone membrane;GO:0031201,SNARE complex;GO:0036477,somatodendritic compartment;GO:0042581,specific granule;GO:0000322,storage vacuole;GO:0045202,synapse;GO:0008021,synaptic vesicle;GO:0005802,trans-Golgi network;GO:0005773,vacuole	GO:0005484,SNAP receptor activity;GO:0000149,SNARE binding;GO:0016230,sphingomyelin phosphodiesterase activator activity	GO:0071346,cellular response to interferon-gamma;GO:0034599,cellular response to oxidative stress;GO:1903575,cornified envelope assembly;GO:0019221,cytokine-mediated signaling pathway;GO:0006887,exocytosis;GO:0006886,intracellular protein transport;GO:0060291,long-term synaptic potentiation;GO:0048284,organelle fusion;GO:0043085,positive regulation of catalytic activity;GO:0045785,positive regulation of cell adhesion;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0050921,positive regulation of chemotaxis;GO:0043311,positive regulation of eosinophil degranulation;GO:0002639,positive regulation of immunoglobulin production;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:2000010,positive regulation of protein localization to cell surface;GO:1903078,positive regulation of protein localization to plasma membrane;GO:0006892,post-Golgi vesicle-mediated transport;GO:0017157,regulation of exocytosis;GO:1902041,regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0035493,SNARE complex assembly;GO:0031629,synaptic vesicle fusion to presynaptic active zone membrane;GO:0048278,vesicle docking;GO:0006906,vesicle fusion;GO:1990668,vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane;GO:0016192,vesicle-mediated transport	hsa:6810,path:hsa04130,SNARE interactions in vesicular transport;hsa:6810,path:hsa04962,Vasopressin-regulated water reabsorption
ES8L2_HUMAN	Q9H6S3	EPS8L2	Epidermal growth factor receptor kinase substrate 8-like protein 2	0.586223251	1.793134139	3.587396988	8.863100311	1.189678695	6.2252486495	1.189678695	6.2252486495	0.19110540991733	0.013049	-1	5.23271424096571	0.013142	1	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0032587,ruffle membrane;GO:0032421,stereocilium bundle;GO:0032426,stereocilium tip;GO:0031982,vesicle;GO:0005737,cytoplasm	GO:0003779,actin binding;GO:0045296,cadherin binding	GO:1900029,positive regulation of ruffle assembly;GO:0050790,regulation of catalytic activity;GO:0035023,regulation of Rho protein signal transduction;GO:0007266,Rho protein signal transduction;GO:0007605,sensory perception of sound	
DAD1_HUMAN	P61803	DAD1	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1	2.813158144	2.570213604	2.88931855	1.537079785	2.691685874	2.2131991675	2.691685874	2.2131991675	1.21619685816189	0.369635	0	0.822235309431207	0.369307	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0008250,oligosaccharyltransferase complex	GO:0008047,enzyme activator activity	GO:0006915,apoptotic process;GO:0001824,blastocyst development;GO:0043066,negative regulation of apoptotic process;GO:0006486,protein glycosylation;GO:0006487,protein N-linked glycosylation;GO:0018279,protein N-linked glycosylation via asparagine;GO:0031647,regulation of protein stability;GO:0042493,response to drug;GO:0007584,response to nutrient;GO:0019082,viral protein processing	hsa:1603,path:hsa00510,N-Glycan biosynthesis;hsa:1603,path:hsa00513,Various types of N-glycan biosynthesis;hsa:1603,path:hsa04141,Protein processing in endoplasmic reticulum
DDX58_HUMAN	O95786	DDX58	Antiviral innate immune response receptor RIG-I	0.965823935	0.777944029	1.0892616	1.295568098	0.871883982	1.192414849	0.871883982	1.192414849	0.731191818628552	0.430885	0	1.36763018201658	0.431052	0	GO:0015629,actin cytoskeleton;GO:0005923,bicellular tight junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005886,plasma membrane;GO:1990904,ribonucleoprotein complex;GO:0032587,ruffle membrane	GO:0005524,ATP binding;GO:0003725,double-stranded RNA binding;GO:0016787,hydrolase activity;GO:0042802,identical protein binding;GO:0003724,RNA helicase activity;GO:0003727,single-stranded RNA binding;GO:0031625,ubiquitin protein ligase binding;GO:0008270,zinc ion binding;GO:0003723,RNA binding	GO:0140374,antiviral innate immune response;GO:0071360,cellular response to exogenous dsRNA;GO:0039528,cytoplasmic pattern recognition receptor signaling pathway in response to virus;GO:0051607,defense response to virus;GO:0009597,detection of virus;GO:0045087,innate immune response;GO:0032480,negative regulation of type I interferon production;GO:0002230,positive regulation of defense response to virus by host;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0010628,positive regulation of gene expression;GO:0032725,positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032727,positive regulation of interferon-alpha production;GO:0032728,positive regulation of interferon-beta production;GO:0032755,positive regulation of interleukin-6 production;GO:0032757,positive regulation of interleukin-8 production;GO:0002735,positive regulation of myeloid dendritic cell cytokine production;GO:0060760,positive regulation of response to cytokine stimulus;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0032760,positive regulation of tumor necrosis factor production;GO:0016579,protein deubiquitination;GO:0030334,regulation of cell migration;GO:0034344,regulation of type III interferon production;GO:0043330,response to exogenous dsRNA;GO:0009615,response to virus;GO:0039529,RIG-I signaling pathway;GO:0016032,viral process	hsa:23586,path:hsa04064,NF-kappa B signaling pathway;hsa:23586,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:23586,path:hsa04623,Cytosolic DNA-sensing pathway;hsa:23586,path:hsa05162,Measles;hsa:23586,path:hsa05164,Influenza A;hsa:23586,path:hsa05161,Hepatitis B;hsa:23586,path:hsa05160,Hepatitis C;hsa:23586,path:hsa05168,Herpes simplex virus 1 infection;hsa:23586,path:hsa05169,Epstein-Barr virus infection
BGLR_HUMAN	P08236	GUSB	Beta-glucuronidase	1.063214782	1.637780924	0.920192596	0.587809248	1.350497853	0.754000922	1.350497853	0.754000922	1.79110902068632	0.254916	0	0.558313306700237	0.254404	0	GO:0035578,azurophil granule lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0043231,intracellular membrane-bounded organelle;GO:0043202,lysosomal lumen;GO:0016020,membrane	GO:0004566,beta-glucuronidase activity;GO:0030246,carbohydrate binding;GO:0019904,protein domain specific binding;GO:0005102,signaling receptor binding	GO:0005975,carbohydrate metabolic process;GO:0019391,glucuronoside catabolic process;GO:0006027,glycosaminoglycan catabolic process;GO:0030214,hyaluronan catabolic process;GO:0043312,neutrophil degranulation	hsa:2990,path:hsa00040,Pentose and glucuronate interconversions;hsa:2990,path:hsa00531,Glycosaminoglycan degradation;hsa:2990,path:hsa00860,Porphyrin and chlorophyll metabolism;hsa:2990,path:hsa00983,Drug metabolism - other enzymes;hsa:2990,path:hsa04142,Lysosome
HNRPC_HUMAN	P07910	HNRNPC	Heterogeneous nuclear ribonucleoproteins C1/C2	20.49672702	34.05179981	22.25684889	15.76572787	27.274263415	19.01128838	27.274263415	19.01128838	1.43463519514504	0.318447	0	0.697041312930357	0.318026	0	GO:0015629,actin cytoskeleton;GO:0071013,catalytic step 2 spliceosome;GO:0000785,chromatin;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0005681,spliceosomal complex;GO:0005697,telomerase holoenzyme complex	GO:0042802,identical protein binding;GO:0003730,mRNA 3'-UTR binding;GO:1990247,N6-methyladenosine-containing RNA binding;GO:0031492,nucleosomal DNA binding;GO:0008266,poly(U) RNA binding;GO:0003723,RNA binding;GO:0070034,telomerase RNA binding	GO:0070935,3'-UTR-mediated mRNA stabilization;GO:0043044,ATP-dependent chromatin remodeling;GO:0000398,mRNA splicing, via spliceosome;GO:0032211,negative regulation of telomere maintenance via telomerase;GO:0001649,osteoblast differentiation;GO:0016070,RNA metabolic process;GO:0008380,RNA splicing	hsa:3183,path:hsa03040,Spliceosome
SPB12_HUMAN	Q96P63	SERPINB12	Serpin B12	0.348553849	0.793824436	0.194684974	0.096027509	0.5711891425	0.1453562415	0.5711891425	0.1453562415	3.9295811215647	0.093195	0	0.254480049924969	0.092683	0	GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005615,extracellular space;GO:0101003,ficolin-1-rich granule membrane;GO:0005886,plasma membrane	GO:0019899,enzyme binding;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0002244,hematopoietic progenitor cell differentiation;GO:0010951,negative regulation of endopeptidase activity;GO:0042177,negative regulation of protein catabolic process;GO:0043312,neutrophil degranulation	
EMC4_HUMAN	Q5J8M3	EMC4	ER membrane protein complex subunit 4	0.228135347	0.38647453	0.016898948	2.55E-05	0.3073049385	0.008462224	0.3073049385	0.008462224	36.3149141998605	0.000698	1	0.0275368955712373	0.000680	-1	GO:0072546,EMC complex;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0005789,endoplasmic reticulum membrane		GO:0006915,apoptotic process;GO:0045050,protein insertion into ER membrane by stop-transfer membrane-anchor sequence;GO:0071816,tail-anchored membrane protein insertion into ER membrane	
SSDH_HUMAN	P51649	ALDH5A1	Succinate-semialdehyde dehydrogenase, mitochondrial	0.20496145	0.697075719	0.59278116	0.409542451	0.4510185845	0.5011618055	0.4510185845	0.5011618055	0.899946044471659	0.468519	0	1.11117772686815	0.468399	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0042802,identical protein binding;GO:0004777,succinate-semialdehyde dehydrogenase (NAD+) activity;GO:0016491,oxidoreductase activity;GO:0016620,oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	GO:0007417,central nervous system development;GO:0009450,gamma-aminobutyric acid catabolic process;GO:0006536,glutamate metabolic process;GO:0042135,neurotransmitter catabolic process;GO:0009791,post-embryonic development;GO:0006105,succinate metabolic process	hsa:7915,path:hsa00650,Butanoate metabolism;hsa:7915,path:hsa00250,Alanine, aspartate and glutamate metabolism
RT26_HUMAN	Q9BYN8	MRPS26	28S ribosomal protein S26, mitochondrial	0.588248464	3.026666208	0.076585076	2.55E-05	1.807457336	0.038305288	1.807457336	0.038305288	47.1855827320761	0.000317	1	0.0211929140661055	0.000308	-1	GO:0005743,mitochondrial inner membrane;GO:0005763,mitochondrial small ribosomal subunit;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0003723,RNA binding	GO:0042769,DNA damage response, detection of DNA damage;GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination	
HTRA2_HUMAN	O43464	HTRA2	Serine protease HTRA2, mitochondrial	0.115825907	0.111838049	0.224661068	0.133310667	0.113831978	0.1789858675	0.113831978	0.1789858675	0.6359830504495	0.349262	0	1.5723689480297	0.349510	0	GO:0035631,CD40 receptor complex;GO:0000785,chromatin;GO:0009898,cytoplasmic side of plasma membrane;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016020,membrane;GO:0005758,mitochondrial intermembrane space;GO:0031966,mitochondrial membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:1905370,serine-type endopeptidase complex	GO:0042802,identical protein binding;GO:0008233,peptidase activity;GO:0004252,serine-type endopeptidase activity;GO:0008236,serine-type peptidase activity;GO:0051082,unfolded protein binding	GO:0007628,adult walking behavior;GO:0007568,aging;GO:0044257,cellular protein catabolic process;GO:0071363,cellular response to growth factor stimulus;GO:0034605,cellular response to heat;GO:0035458,cellular response to interferon-beta;GO:0034599,cellular response to oxidative stress;GO:0071300,cellular response to retinoic acid;GO:0006672,ceramide metabolic process;GO:0097194,execution phase of apoptosis;GO:0030900,forebrain development;GO:0008630,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0007005,mitochondrion organization;GO:0045786,negative regulation of cell cycle;GO:1904924,negative regulation of mitophagy in response to mitochondrial depolarization;GO:1901215,negative regulation of neuron death;GO:1902176,negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:0048666,neuron development;GO:0019742,pentacyclic triterpenoid metabolic process;GO:0043065,positive regulation of apoptotic process;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:2001269,positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:2001241,positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0010822,positive regulation of mitochondrion organization;GO:1903955,positive regulation of protein targeting to mitochondrion;GO:0012501,programmed cell death;GO:0016540,protein autoprocessing;GO:0006508,proteolysis;GO:1903146,regulation of autophagy of mitochondrion;GO:0040014,regulation of multicellular organism growth;GO:0009635,response to herbicide	hsa:27429,path:hsa04210,Apoptosis;hsa:27429,path:hsa04215,Apoptosis - multiple species;hsa:27429,path:hsa05012,Parkinson disease
ACATN_HUMAN	O00400	SLC33A1	Acetyl-coenzyme A transporter 1	0.083704433	0.088116744	0.35701286	0.160744769	0.0859105885	0.2588788145	0.0859105885	0.2588788145	0.331856388735124	0.083582	0	3.01335166037188	0.083861	0	GO:0005789,endoplasmic reticulum membrane;GO:0000139,Golgi membrane;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0016021,integral component of membrane	GO:0008521,acetyl-CoA transmembrane transporter activity;GO:0015295,solute	GO:0030509,BMP signaling pathway;GO:0060395,SMAD protein signal transduction;GO:0055085,transmembrane transport	hsa:9197,path:hsa00604,Glycosphingolipid biosynthesis - ganglio series
S35B2_HUMAN	Q8TB61	SLC35B2	Adenosine 3'-phospho 5'-phosphosulfate transporter 1	0.436600247	0.214800273	0.293620547	0.103483164	0.32570026	0.1985518555	0.32570026	0.1985518555	1.64037882788761	0.279272	0	0.609615280933457	0.278791	0	GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0030173,integral component of Golgi membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0046964,3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity;GO:0022857,transmembrane transporter activity	GO:0050428,3'-phosphoadenosine 5'-phosphosulfate biosynthetic process;GO:0046963,3'-phosphoadenosine 5'-phosphosulfate transport;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling	
BASP1_HUMAN	P80723	BASP1	Brain acid soluble protein 1	0.039327692	0.096680193	0.057771069	0.0139285	0.0680039425	0.0358497845	0.0680039425	0.0358497845	1.89691356443161	0.239636	0	0.527172148879457	0.239107	0	GO:0030054,cell junction;GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0070062,extracellular exosome;GO:0030426,growth cone;GO:0016363,nuclear matrix;GO:0016607,nuclear speck;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0016605,PML body;GO:0031982,vesicle	GO:0019904,protein domain specific binding;GO:0003714,transcription corepressor activity;GO:0000976,transcription regulatory region sequence-specific DNA binding	GO:0060539,diaphragm development;GO:0072112,glomerular visceral epithelial cell differentiation;GO:0008406,gonad development;GO:0060231,mesenchymal to epithelial transition;GO:0072075,metanephric mesenchyme development;GO:0045892,negative regulation of transcription, DNA-templated;GO:0060421,positive regulation of heart growth;GO:2001076,positive regulation of metanephric ureteric bud development;GO:0021762,substantia nigra development;GO:0007356,thorax and anterior abdomen determination	
MGST3_HUMAN	O14880	MGST3	Microsomal glutathione S-transferase 3	2.935826996	4.900862285	0.603474512	0.629781185	3.9183446405	0.6166278485	3.9183446405	0.6166278485	6.35447239373264	0.042134	1	0.157369477438645	0.041778	-1	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005635,nuclear envelope	GO:0004602,glutathione peroxidase activity;GO:0042802,identical protein binding;GO:0004464,leukotriene-C4 synthase activity;GO:0016740,transferase activity	GO:0046222,aflatoxin metabolic process;GO:1901687,glutathione derivative biosynthetic process;GO:0019370,leukotriene biosynthetic process;GO:0006629,lipid metabolic process;GO:0010243,response to organonitrogen compound	hsa:4259,path:hsa00480,Glutathione metabolism;hsa:4259,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:4259,path:hsa00982,Drug metabolism - cytochrome P450;hsa:4259,path:hsa00983,Drug metabolism - other enzymes;hsa:4259,path:hsa05200,Pathways in cancer;hsa:4259,path:hsa05204,Chemical carcinogenesis;hsa:4259,path:hsa05225,Hepatocellular carcinoma;hsa:4259,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:4259,path:hsa01524,Platinum drug resistance
SYTC_HUMAN	P26639	TARS1	Threonine--tRNA ligase 1, cytoplasmic	5.040198231	3.229938829	4.876474728	7.105944055	4.13506853	5.9912093915	4.13506853	5.9912093915	0.690189285633483	0.396539	0	1.44887789598495	0.396743	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005737,cytoplasm	GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0004829,threonine-tRNA ligase activity;GO:0000049,tRNA binding;GO:0008270,zinc ion binding	GO:0006435,threonyl-tRNA aminoacylation;GO:0006418,tRNA aminoacylation for protein translation	hsa:6897,path:hsa00970,Aminoacyl-tRNA biosynthesis
RHG25_HUMAN	P42331	ARHGAP25	Rho GTPase-activating protein 25	0.245202572	0.273762508	0.494713535	0.333770928	0.25948254	0.4142422315	0.25948254	0.4142422315	0.626402911794859	0.340716	0	1.59641658933969	0.340972	0	GO:0005829,cytosol;GO:0001891,phagocytic cup	GO:0005096,GTPase activator activity	GO:0007015,actin filament organization;GO:0090630,activation of GTPase activity;GO:0051058,negative regulation of small GTPase mediated signal transduction;GO:0006911,phagocytosis, engulfment;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007165,signal transduction;GO:0043547,positive regulation of GTPase activity	
HECD3_HUMAN	Q5T447	HECTD3	E3 ubiquitin-protein ligase HECTD3	0.121834369	0.093146802	0.15499747	0.419410213	0.1074905855	0.2872038415	0.1074905855	0.2872038415	0.374265834811266	0.115540	0	2.6718976379564	0.115852	0	GO:0048471,perinuclear region of cytoplasm	GO:0019905,syntaxin binding;GO:0004842,ubiquitin-protein transferase activity	GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process	
ATG4B_HUMAN	Q9Y4P1	ATG4B	Cysteine protease ATG4B	0.039487329	0.021237977	0.066945676	0.04715074	0.030362653	0.057048208	0.030362653	0.057048208	0.532227988651282	0.254791	0	1.87889404789496	0.255107	0	GO:0005829,cytosol;GO:0005737,cytoplasm	GO:0004197,cysteine-type endopeptidase activity;GO:0008234,cysteine-type peptidase activity;GO:0004175,endopeptidase activity	GO:0006914,autophagy;GO:0016236,macroautophagy;GO:0045732,positive regulation of protein catabolic process;GO:0051697,protein delipidation;GO:0015031,protein transport;GO:0006508,proteolysis	hsa:23192,path:hsa04140,Autophagy - animal;hsa:23192,path:hsa04136,Autophagy - other
DGLB_HUMAN	Q8NCG7	DAGLB	Diacylglycerol lipase-beta	0.217964883	0.364026379	0.198533379	1.091377014	0.290995631	0.6449551965	0.290995631	0.6449551965	0.451187357787263	0.180902	0	2.21637415752129	0.181237	0	GO:0016021,integral component of membrane;GO:0005765,lysosomal membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0045211,postsynaptic membrane	GO:0016298,lipase activity;GO:0046872,metal ion binding;GO:0004806,triglyceride lipase activity	GO:0019369,arachidonic acid metabolic process;GO:0071926,endocannabinoid signaling pathway;GO:0007216,G protein-coupled glutamate receptor signaling pathway;GO:0016042,lipid catabolic process;GO:0007405,neuroblast proliferation;GO:0022008,neurogenesis;GO:0042136,neurotransmitter biosynthetic process;GO:0010898,positive regulation of triglyceride catabolic process;GO:0001516,prostaglandin biosynthetic process;GO:0050727,regulation of inflammatory response;GO:0098921,retrograde trans-synaptic signaling by endocannabinoid;GO:0006629,lipid metabolic process	hsa:221955,path:hsa04925,Aldosterone synthesis and secretion;hsa:221955,path:hsa04723,Retrograde endocannabinoid signaling
CBR3_HUMAN	O75828	CBR3	Carbonyl reductase [NADPH] 3	0.812281472	0.789700848	1.339785354	0.796090107	0.80099116	1.0679377305	0.80099116	1.0679377305	0.750035453495011	0.446212	0	1.33327030787706	0.446363	0	GO:0005829,cytosol;GO:0005615,extracellular space;GO:0005654,nucleoplasm	GO:0000253,3-keto sterol reductase activity;GO:0004090,carbonyl reductase (NADPH) activity;GO:0070402,NADPH binding	GO:0050890,cognition;GO:0042376,phylloquinone catabolic process;GO:0006805,xenobiotic metabolic process	hsa:874,path:hsa00590,Arachidonic acid metabolism;hsa:874,path:hsa00980,Metabolism of xenobiotics by cytochrome P450
UBC9_HUMAN	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.659435186	1.661749025	0.0639543	0.002619139	1.1605921055	0.0332867195	1.1605921055	0.0332867195	34.8665210310076	0.000785	1	0.0286808081342752	0.000766	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005635,nuclear envelope;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016605,PML body;GO:1990356,sumoylated E2 ligase complex;GO:0000795,synaptonemal complex;GO:1990234,transferase complex;GO:0016604,nuclear body	GO:0005524,ATP binding;GO:0019899,enzyme binding;GO:0071535,RING-like zinc finger domain binding;GO:0003723,RNA binding;GO:0044388,small protein activating enzyme binding;GO:0061656,SUMO conjugating enzyme activity;GO:0019789,SUMO transferase activity;GO:0001221,transcription coregulator binding;GO:0008134,transcription factor binding;GO:0043398,HLH domain binding;GO:0016740,transferase activity	GO:0051301,cell division;GO:0006464,cellular protein modification process;GO:0007059,chromosome segregation;GO:0007084,mitotic nuclear envelope reassembly;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:1903755,positive regulation of SUMO transferase activity;GO:0016925,protein sumoylation;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0019082,viral protein processing;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling	hsa:7329,path:hsa03013,RNA transport;hsa:7329,path:hsa04120,Ubiquitin mediated proteolysis;hsa:7329,path:hsa04064,NF-kappa B signaling pathway;hsa:7329,path:hsa05206,MicroRNAs in cancer
K2C3_HUMAN	P12035	KRT3	Keratin, type II cytoskeletal 3	0.050576725	5.21821399	0.115566431	0.061705798	2.6343953575	0.0886361145	2.6343953575	0.0886361145	29.7214670606979	0.001236	1	0.033645714659972	0.001208	-1	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005882,intermediate filament;GO:0045095,keratin filament		GO:0070268,cornification;GO:0030855,epithelial cell differentiation;GO:0045104,intermediate filament cytoskeleton organization;GO:0031424,keratinization	
NP1L4_HUMAN	Q99733	NAP1L4	Nucleosome assembly protein 1-like 4	2.312893665	0.379610941	2.043471991	1.901886246	1.346252303	1.9726791185	1.346252303	1.9726791185	0.682448701552472	0.389911	0	1.46531160177336	0.390121	0	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005634,nucleus	GO:0003682,chromatin binding;GO:0042393,histone binding;GO:0031491,nucleosome binding;GO:0003723,RNA binding;GO:0051082,unfolded protein binding	GO:0006334,nucleosome assembly	
SUMO4_HUMAN	Q6EEV6	SUMO4	Small ubiquitin-related modifier 4	1.718867441	6.735740945	0.378448737	1.150125466	4.227304193	0.7642871015	4.227304193	0.7642871015	5.53104217604018	0.053758	0	0.18079775351052	0.053353	0	GO:0005634,nucleus;GO:0106068,SUMO ligase complex	GO:0031386,protein tag;GO:0044389,ubiquitin-like protein ligase binding	GO:0034599,cellular response to oxidative stress;GO:0043392,negative regulation of DNA binding;GO:0045892,negative regulation of transcription, DNA-templated;GO:0043388,positive regulation of DNA binding;GO:0016925,protein sumoylation;GO:0043122,regulation of I-kappaB kinase/NF-kappaB signaling;GO:1900180,regulation of protein localization to nucleus	hsa:387082,path:hsa03013,RNA transport;hsa:387082,path:hsa05418,Fluid shear stress and atherosclerosis
RAB25_HUMAN	P57735	RAB25	Ras-related protein Rab-25	1.462476063	2.515468405	0.165577547	0.030110527	1.988972234	0.097844037	1.988972234	0.097844037	20.3279862011417	0.003399	1	0.0491932644043134	0.003337	-1	GO:0031410,cytoplasmic vesicle;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0031143,pseudopodium;GO:0031260,pseudopodium membrane;GO:0055037,recycling endosome	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0031489,myosin V binding	GO:0003382,epithelial cell morphogenesis;GO:0006887,exocytosis;GO:0008284,positive regulation of cell population proliferation;GO:0010634,positive regulation of epithelial cell migration;GO:0015031,protein transport;GO:0031268,pseudopodium organization;GO:0060627,regulation of vesicle-mediated transport	
SHIP1_HUMAN	Q92835	INPP5D	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	0.403503394	0.306021752	0.567493351	1.233378496	0.354762573	0.9004359235	0.354762573	0.9004359235	0.393989803984092	0.131550	0	2.53813674843316	0.131873	0	GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0045121,membrane raft;GO:0005886,plasma membrane	GO:0052659,inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;GO:0052658,inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0004445,inositol-polyphosphate 5-phosphatase activity;GO:0034485,phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity;GO:0004439,phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0017124,SH3 domain binding;GO:0016787,hydrolase activity	GO:0006915,apoptotic process;GO:0019221,cytokine-mediated signaling pathway;GO:0008340,determination of adult lifespan;GO:0016064,immunoglobulin mediated immune response;GO:0043647,inositol phosphate metabolic process;GO:0035556,intracellular signal transduction;GO:0050900,leukocyte migration;GO:0030889,negative regulation of B cell proliferation;GO:0045779,negative regulation of bone resorption;GO:0050777,negative regulation of immune response;GO:0032715,negative regulation of interleukin-6 production;GO:0045656,negative regulation of monocyte differentiation;GO:0045659,negative regulation of neutrophil differentiation;GO:0045671,negative regulation of osteoclast differentiation;GO:0009968,negative regulation of signal transduction;GO:0006796,phosphate-containing compound metabolic process;GO:0006661,phosphatidylinositol biosynthetic process;GO:0046856,phosphatidylinositol dephosphorylation;GO:0043065,positive regulation of apoptotic process;GO:0045579,positive regulation of B cell differentiation;GO:0045648,positive regulation of erythrocyte differentiation;GO:0007165,signal transduction;GO:0050852,T cell receptor signaling pathway	hsa:3635,path:hsa00562,Inositol phosphate metabolism;hsa:3635,path:hsa04070,Phosphatidylinositol signaling system;hsa:3635,path:hsa04662,B cell receptor signaling pathway;hsa:3635,path:hsa04664,Fc epsilon RI signaling pathway;hsa:3635,path:hsa04666,Fc gamma R-mediated phagocytosis
IF2P_HUMAN	O60841	EIF5B	Eukaryotic translation initiation factor 5B	1.294515599	1.183827571	1.930622029	1.46141887	1.239171585	1.6960204495	1.239171585	1.6960204495	0.730634813610483	0.430427	0	1.36867280530807	0.430595	0	GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0046872,metal ion binding;GO:0003723,RNA binding;GO:0003743,translation initiation factor activity	GO:0006446,regulation of translational initiation	hsa:9669,path:hsa03013,RNA transport
KAT3_HUMAN	Q6YP21	KYAT3	Kynurenine--oxoglutarate transaminase 3	0.151826532	0.127102586	0.425337374	0.346626629	0.139464559	0.3859820015	0.139464559	0.3859820015	0.361323995569778	0.105401	0	2.76759919701177	0.105705	0	GO:0005737,cytoplasm;GO:0005739,mitochondrion	GO:0047804,cysteine-S-conjugate beta-lyase activity;GO:0047315,kynurenine-glyoxylate transaminase activity;GO:0016212,kynurenine-oxoglutarate transaminase activity;GO:0042803,protein homodimerization activity;GO:0030170,pyridoxal phosphate binding;GO:0003723,RNA binding	GO:0006103,2-oxoglutarate metabolic process;GO:0009058,biosynthetic process;GO:0006520,cellular amino acid metabolic process;GO:0070189,kynurenine metabolic process;GO:0097053,L-kynurenine catabolic process	hsa:56267,path:hsa00270,Cysteine and methionine metabolism;hsa:56267,path:hsa00380,Tryptophan metabolism;hsa:56267,path:hsa00450,Selenocompound metabolism;hsa:56267,path:hsa05204,Chemical carcinogenesis
ARMT1_HUMAN	Q9H993	ARMT1	Damage-control phosphatase ARMT1	0.472946206	0.719755436	1.463185846	0.631030799	0.596350821	1.0471083225	0.596350821	1.0471083225	0.569521613175795	0.289108	0	1.75585961421859	0.289404	0		GO:0019899,enzyme binding;GO:0097023,fructose 6-phosphate aldolase activity;GO:0103026,fructose-1-phosphatase activity;GO:0046872,metal ion binding;GO:0016791,phosphatase activity;GO:0051998,protein carboxyl O-methyltransferase activity;GO:0008983,protein-glutamate O-methyltransferase activity;GO:0008757,S-adenosylmethionine-dependent methyltransferase activity	GO:0006974,cellular response to DNA damage stimulus;GO:0032259,methylation;GO:2001020,regulation of response to DNA damage stimulus	
SURF6_HUMAN	O75683	SURF6	Surfeit locus protein 6	1.681152297	1.529226082	1.328756545	6.448696952	1.6051891895	3.8887267485	1.6051891895	3.8887267485	0.412780144585672	0.147343	0	2.42259714551859	0.147673	0	GO:0005694,chromosome;GO:0001652,granular component;GO:0005730,nucleolus;GO:0005654,nucleoplasm	GO:0003677,DNA binding;GO:0003723,RNA binding	GO:0042273,ribosomal large subunit biogenesis;GO:0042274,ribosomal small subunit biogenesis	
ILF2_HUMAN	Q12905	ILF2	Interleukin enhancer-binding factor 2	6.875484879	4.639843646	10.16603966	5.281235409	5.7576642625	7.7236375345	5.7576642625	7.7236375345	0.745460184632127	0.442518	0	1.34145326687499	0.442673	0	GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen	GO:0003677,DNA binding;GO:0003725,double-stranded RNA binding;GO:0003723,RNA binding	GO:0043312,neutrophil degranulation;GO:0045893,positive regulation of transcription, DNA-templated	
DREB_HUMAN	Q16643	DBN1	Drebrin	1.110052587	0.875124124	0.789472485	0.977757604	0.9925883555	0.8836150445	0.9925883555	0.8836150445	1.12332668131705	0.395170	0	0.890212986686604	0.394893	0	GO:0015629,actin cytoskeleton;GO:0042641,actomyosin;GO:0030864,cortical actin cytoskeleton;GO:0030863,cortical cytoskeleton;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0030425,dendrite;GO:0005921,gap junction;GO:0098978,glutamatergic synapse;GO:0030426,growth cone;GO:0030027,lamellipodium;GO:0005886,plasma membrane;GO:0099524,postsynaptic cytosol;GO:0014069,postsynaptic density;GO:0045211,postsynaptic membrane;GO:0030427,site of polarized growth	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0045296,cadherin binding;GO:0005522,profilin binding	GO:0007015,actin filament organization;GO:0010643,cell communication by chemical coupling;GO:0010644,cell communication by electrical coupling;GO:0051220,cytoplasmic sequestering of protein;GO:0001701,in utero embryonic development;GO:0032507,maintenance of protein location in cell;GO:0061351,neural precursor cell proliferation;GO:0048812,neuron projection morphogenesis;GO:0045773,positive regulation of axon extension;GO:0061003,positive regulation of dendritic spine morphogenesis;GO:1902685,positive regulation of receptor localization to synapse;GO:0031915,positive regulation of synaptic plasticity;GO:0098974,postsynaptic actin cytoskeleton organization;GO:0030833,regulation of actin filament polymerization;GO:0050773,regulation of dendrite development;GO:0048168,regulation of neuronal synaptic plasticity	
QCR2_HUMAN	P22695	UQCRC2	Cytochrome b-c1 complex subunit 2, mitochondrial	7.187922234	5.065916922	13.19841766	9.581464208	6.126919578	11.389940934	6.126919578	11.389940934	0.537923735821192	0.260040	0	1.85899958192662	0.260353	0	GO:0005743,mitochondrial inner membrane;GO:0005750,mitochondrial respiratory chain complex III;GO:0005751,mitochondrial respiratory chain complex IV;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0046872,metal ion binding;GO:0044877,protein-containing complex binding	GO:0009060,aerobic respiration;GO:0006122,mitochondrial electron transport, ubiquinol to cytochrome c;GO:0006119,oxidative phosphorylation;GO:0006508,proteolysis;GO:0042493,response to drug	hsa:7385,path:hsa00190,Oxidative phosphorylation;hsa:7385,path:hsa04260,Cardiac muscle contraction;hsa:7385,path:hsa04714,Thermogenesis;hsa:7385,path:hsa05010,Alzheimer disease;hsa:7385,path:hsa05012,Parkinson disease;hsa:7385,path:hsa05016,Huntington disease;hsa:7385,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
TM9S2_HUMAN	Q99805	TM9SF2	Transmembrane 9 superfamily member 2	0.404741126	0.665775447	1.011573476	2.55E-05	0.5352582865	0.505799488	0.5352582865	0.505799488	1.05824204887293	0.414664	0	0.94496339572316	0.414428	0	GO:0005856,cytoskeleton;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0016020,membrane		GO:0072657,protein localization to membrane	
1433G_HUMAN	P61981	YWHAG	14-3-3 protein gamma	4.333051034	4.594846678	3.769487348	4.247109919	4.463948856	4.0082986335	4.463948856	4.0082986335	1.11367671527561	0.397973	0	0.897926648087027	0.397702	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0098793,presynapse	GO:0042802,identical protein binding;GO:0005159,insulin-like growth factor receptor binding;GO:0019904,protein domain specific binding;GO:0005080,protein kinase C binding;GO:0008426,protein kinase C inhibitor activity;GO:0030971,receptor tyrosine kinase binding;GO:0003723,RNA binding	GO:0032869,cellular response to insulin stimulus;GO:0097711,ciliary basal body-plasma membrane docking;GO:0000086,G2/M transition of mitotic cell cycle;GO:0006469,negative regulation of protein kinase activity;GO:1900740,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0006605,protein targeting;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0045664,regulation of neuron differentiation;GO:0009966,regulation of signal transduction;GO:0048167,regulation of synaptic plasticity	hsa:7532,path:hsa04390,Hippo signaling pathway;hsa:7532,path:hsa04151,PI3K-Akt signaling pathway;hsa:7532,path:hsa04110,Cell cycle;hsa:7532,path:hsa04114,Oocyte meiosis;hsa:7532,path:hsa05203,Viral carcinogenesis;hsa:7532,path:hsa05160,Hepatitis C
RAC2_HUMAN	P15153	RAC2	Ras-related C3 botulinum toxin substrate 2	4.721469027	46.71691342	1.09249234	0.541128958	25.7191912235	0.816810649	25.7191912235	0.816810649	31.4873358409165	0.001051	1	0.0317587999522189	0.001027	-1	GO:0005938,cell cortex;GO:0042995,cell projection;GO:0031410,cytoplasmic vesicle;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0043231,intracellular membrane-bounded organelle;GO:0030027,lamellipodium;GO:0005635,nuclear envelope;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0019901,protein kinase binding;GO:0019887,protein kinase regulator activity	GO:0007015,actin filament organization;GO:0045453,bone resorption;GO:0030031,cell projection assembly;GO:0045454,cell redox homeostasis;GO:0030865,cortical cytoskeleton organization;GO:0043652,engulfment of apoptotic cell;GO:0007163,establishment or maintenance of cell polarity;GO:0007186,G protein-coupled receptor signaling pathway;GO:0071593,lymphocyte aggregation;GO:0008045,motor neuron axon guidance;GO:0008284,positive regulation of cell population proliferation;GO:0010592,positive regulation of lamellipodium assembly;GO:0090023,positive regulation of neutrophil chemotaxis;GO:0051897,positive regulation of protein kinase B signaling;GO:1903955,positive regulation of protein targeting to mitochondrion;GO:0016601,Rac protein signal transduction;GO:0032956,regulation of actin cytoskeleton organization;GO:0008360,regulation of cell shape;GO:0010810,regulation of cell-substrate adhesion;GO:0010310,regulation of hydrogen peroxide metabolic process;GO:0060753,regulation of mast cell chemotaxis;GO:0043304,regulation of mast cell degranulation;GO:1902622,regulation of neutrophil migration;GO:0060263,regulation of respiratory burst;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0042129,regulation of T cell proliferation;GO:0007165,signal transduction;GO:0007264,small GTPase mediated signal transduction	hsa:5880,path:hsa04014,Ras signaling pathway;hsa:5880,path:hsa04015,Rap1 signaling pathway;hsa:5880,path:hsa04010,MAPK signaling pathway;hsa:5880,path:hsa04310,Wnt signaling pathway;hsa:5880,path:hsa04370,VEGF signaling pathway;hsa:5880,path:hsa04071,Sphingolipid signaling pathway;hsa:5880,path:hsa04024,cAMP signaling pathway;hsa:5880,path:hsa04510,Focal adhesion;hsa:5880,path:hsa04520,Adherens junction;hsa:5880,path:hsa04810,Regulation of actin cytoskeleton;hsa:5880,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:5880,path:hsa04662,B cell receptor signaling pathway;hsa:5880,path:hsa04664,Fc epsilon RI signaling pathway;hsa:5880,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:5880,path:hsa04670,Leukocyte transendothelial migration;hsa:5880,path:hsa04062,Chemokine signaling pathway;hsa:5880,path:hsa04360,Axon guidance;hsa:5880,path:hsa05200,Pathways in cancer;hsa:5880,path:hsa05231,Choline metabolism in cancer;hsa:5880,path:hsa05210,Colorectal cancer;hsa:5880,path:hsa05212,Pancreatic cancer;hsa:5880,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:5880,path:hsa05416,Viral myocarditis;hsa:5880,path:hsa05135,Yersinia infection;hsa:5880,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:5880,path:hsa05163,Human cytomegalovirus infection
PI4KA_HUMAN	P42356	PI4KA	Phosphatidylinositol 4-kinase alpha	0.040587464	0.082131126	0.134060747	0.10178917	0.061359295	0.1179249585	0.061359295	0.1179249585	0.520324923413053	0.243824	0	1.92187603361479	0.244145	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0030660,Golgi-associated vesicle membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0004430,1-phosphatidylinositol 4-kinase activity;GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0016301,kinase activity;GO:0052742,phosphatidylinositol kinase activity	GO:0044803,multi-organism membrane organization;GO:0006661,phosphatidylinositol biosynthetic process;GO:0046854,phosphatidylinositol phosphorylation;GO:0048015,phosphatidylinositol-mediated signaling;GO:0016310,phosphorylation;GO:0007165,signal transduction;GO:0046786,viral replication complex formation and maintenance;GO:0039694,viral RNA genome replication	hsa:5297,path:hsa00562,Inositol phosphate metabolism;hsa:5297,path:hsa04070,Phosphatidylinositol signaling system
NEST_HUMAN	P48681	NES	Nestin	0.152386269	0.19780002	0.457397254	1.343157015	0.1750931445	0.9002771345	0.1750931445	0.9002771345	0.19448805016829	0.013976	-1	5.14170407454188	0.014075	1	GO:0005737,cytoplasm;GO:0005882,intermediate filament;GO:0045111,intermediate filament cytoskeleton	GO:0031730,CCR5 chemokine receptor binding;GO:0019215,intermediate filament binding	GO:0007420,brain development;GO:0048858,cell projection morphogenesis;GO:0007417,central nervous system development;GO:0031076,embryonic camera-type eye development;GO:0000086,G2/M transition of mitotic cell cycle;GO:0043086,negative regulation of catalytic activity;GO:0043524,negative regulation of neuron apoptotic process;GO:0032091,negative regulation of protein binding;GO:0030844,positive regulation of intermediate filament depolymerization;GO:2000179,positive regulation of neural precursor cell proliferation;GO:0072089,stem cell proliferation	
CHRD1_HUMAN	Q9UHD1	CHORDC1	Cysteine and histidine-rich domain-containing protein 1	0.214994267	0.315819048	0.387420393	0.431523499	0.2654066575	0.409471946	0.2654066575	0.409471946	0.648168110398459	0.360055	0	1.54280962601701	0.360294	0		GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0051879,Hsp90 protein binding;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0051298,centrosome duplication;GO:0061077,chaperone-mediated protein folding;GO:2000299,negative regulation of Rho-dependent protein serine/threonine kinase activity;GO:1900034,regulation of cellular response to heat;GO:0010824,regulation of centrosome duplication	
PGRC1_HUMAN	O00264	PGRMC1	Membrane-associated progesterone receptor component 1	6.553578389	7.389776837	1.221733821	1.389307074	6.971677613	1.3055204475	6.971677613	1.3055204475	5.3401519879297	0.057070	0	0.18726058776235	0.056652	0	GO:0044297,cell body;GO:0012505,endomembrane system;GO:0005783,endoplasmic reticulum;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0005886,plasma membrane;GO:0030868,smooth endoplasmic reticulum membrane;GO:0035579,specific granule membrane;GO:0045202,synapse	GO:0001540,amyloid-beta binding;GO:0020037,heme binding;GO:0046872,metal ion binding;GO:0042803,protein homodimerization activity;GO:0005496,steroid binding	GO:0006783,heme biosynthetic process;GO:0043312,neutrophil degranulation	
K1C15_HUMAN	P19012	KRT15	Keratin, type I cytoskeletal 15	5.198202304	9.283472383	12.88575683	3.79393264	7.2408373435	8.339844735	7.2408373435	8.339844735	0.868222080096075	0.480561	0	1.15177904700298	0.480468	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005882,intermediate filament;GO:0005634,nucleus	GO:0097110,scaffold protein binding;GO:0005200,structural constituent of cytoskeleton;GO:0005198,structural molecule activity	GO:0070268,cornification;GO:0008544,epidermis development;GO:0031424,keratinization	hsa:3866,path:hsa04915,Estrogen signaling pathway;hsa:3866,path:hsa05150,Staphylococcus aureus infection
PIGR_HUMAN	P01833	PIGR	Polymeric immunoglobulin receptor	0.285450903	1.635880553	0.487667408	0.75888499	0.960665728	0.623276199	0.960665728	0.623276199	1.54131624076343	0.297189	0	0.648796122140833	0.296734	0	GO:0035577,azurophil granule membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane;GO:0043235,receptor complex;GO:0071751,secretory IgA immunoglobulin complex	GO:0001792,polymeric immunoglobulin receptor activity;GO:0004888,transmembrane signaling receptor activity	GO:0001580,detection of chemical stimulus involved in sensory perception of bitter taste;GO:0007173,epidermal growth factor receptor signaling pathway;GO:0038093,Fc receptor signaling pathway;GO:0002415,immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor;GO:0043312,neutrophil degranulation;GO:0043113,receptor clustering;GO:0001895,retina homeostasis	hsa:5284,path:hsa04672,Intestinal immune network for IgA production
MA2A1_HUMAN	Q16706	MAN2A1	Alpha-mannosidase 2	0.975498273	0.819449414	1.413672977	0.657775794	0.8974738435	1.0357243855	0.8974738435	1.0357243855	0.866518019720798	0.481221	0	1.15404409053399	0.481129	0	GO:0005801,cis-Golgi network;GO:0070062,extracellular exosome;GO:0005797,Golgi medial cisterna;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0004559,alpha-mannosidase activity;GO:0030246,carbohydrate binding;GO:0016799,hydrolase activity, hydrolyzing N-glycosyl compounds;GO:0004572,mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity;GO:0046872,metal ion binding;GO:0042803,protein homodimerization activity	GO:0001701,in utero embryonic development;GO:0001889,liver development;GO:0048286,lung alveolus development;GO:0006013,mannose metabolic process;GO:0007005,mitochondrion organization;GO:0006491,N-glycan processing;GO:0050769,positive regulation of neurogenesis;GO:0006517,protein deglycosylation;GO:0006486,protein glycosylation;GO:0007585,respiratory gaseous exchange by respiratory system;GO:0060042,retina morphogenesis in camera-type eye;GO:0007033,vacuole organization;GO:0019082,viral protein processing	hsa:4124,path:hsa00510,N-Glycan biosynthesis;hsa:4124,path:hsa00513,Various types of N-glycan biosynthesis
FAF2_HUMAN	Q96CS3	FAF2	FAS-associated factor 2	0.567343411	0.279616529	0.649138778	0.349655539	0.42347997	0.4993971585	0.42347997	0.4993971585	0.847982337889093	0.488486	0	1.17926984480517	0.488411	0	GO:0035578,azurophil granule lumen;GO:0005783,endoplasmic reticulum;GO:0005576,extracellular region;GO:0005811,lipid droplet;GO:0034098,VCP-NPL4-UFD1 AAA ATPase complex	GO:0035473,lipase binding;GO:0055102,lipase inhibitor activity;GO:0043130,ubiquitin binding;GO:0031625,ubiquitin protein ligase binding	GO:0034389,lipid droplet organization;GO:0043312,neutrophil degranulation;GO:0006986,response to unfolded protein;GO:0030970,retrograde protein transport, ER to cytosol;GO:0030433,ubiquitin-dependent ERAD pathway	
IF2G_HUMAN	P41091	EIF2S3	Eukaryotic translation initiation factor 2 subunit 3	3.662145321	3.039372687	4.577086018	3.298722693	3.350759004	3.9379043555	3.350759004	3.9379043555	0.850899031948314	0.487332	0	1.17522756808206	0.487254	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005850,eukaryotic translation initiation factor 2 complex;GO:0070062,extracellular exosome	GO:0045296,cadherin binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0008135,translation factor activity, RNA binding;GO:0003743,translation initiation factor activity;GO:0000049,tRNA binding	GO:0001731,formation of translation preinitiation complex;GO:0045903,positive regulation of translational fidelity;GO:0006413,translational initiation;GO:0055085,transmembrane transport	hsa:1968,path:hsa03013,RNA transport
ITAX_HUMAN	P20702	ITGAX	Integrin alpha-X	3.980885439	3.131832686	3.71941431	2.792436053	3.5563590625	3.2559251815	3.5563590625	3.2559251815	1.09227296828166	0.404297	0	0.915522061827805	0.404039	0	GO:0009986,cell surface;GO:0101003,ficolin-1-rich granule membrane;GO:0034689,integrin alphaX-beta2 complex;GO:0008305,integrin complex;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0070821,tertiary granule membrane;GO:0009897,external side of plasma membrane	GO:0005178,integrin binding;GO:0046872,metal ion binding;GO:0030971,receptor tyrosine kinase binding;GO:0038023,signaling receptor activity	GO:0009887,animal organ morphogenesis;GO:0007155,cell adhesion;GO:0019221,cytokine-mediated signaling pathway;GO:0030198,extracellular matrix organization;GO:0034113,heterotypic cell-cell adhesion;GO:0007229,integrin-mediated signaling pathway;GO:0050900,leukocyte migration;GO:0043312,neutrophil degranulation;GO:0045766,positive regulation of angiogenesis;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:1905956,positive regulation of endothelial tube morphogenesis;GO:0010628,positive regulation of gene expression;GO:0031643,positive regulation of myelination;GO:0051607,defense response to virus	hsa:3687,path:hsa04810,Regulation of actin cytoskeleton;hsa:3687,path:hsa04610,Complement and coagulation cascades;hsa:3687,path:hsa05152,Tuberculosis
CDIPT_HUMAN	O14735	CDIPT	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	0.963558568	1.028098094	0.191197801	0.208663383	0.995828331	0.199930592	0.995828331	0.199930592	4.98087021619983	0.064111	0	0.20076813018488	0.063670	0	GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0003881,CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity;GO:0016780,phosphotransferase activity, for other substituted phosphate groups;GO:0043178,alcohol binding;GO:0030246,carbohydrate binding;GO:0019992,diacylglycerol binding;GO:0030145,manganese ion binding	GO:0006661,phosphatidylinositol biosynthetic process;GO:0008654,phospholipid biosynthetic process;GO:0046341,CDP-diacylglycerol metabolic process	hsa:10423,path:hsa00562,Inositol phosphate metabolism;hsa:10423,path:hsa00564,Glycerophospholipid metabolism;hsa:10423,path:hsa04070,Phosphatidylinositol signaling system
IF4B_HUMAN	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.77807774	0.549487465	0.453634473	0.082783227	0.6637826025	0.26820885	0.6637826025	0.26820885	2.47487210992478	0.175761	0	0.404061283001162	0.175191	0	GO:0005829,cytosol;GO:0016281,eukaryotic translation initiation factor 4F complex;GO:0030425,dendrite;GO:0043025,neuronal cell body;GO:0098794,postsynapse	GO:0043024,ribosomal small subunit binding;GO:0003723,RNA binding;GO:0033592,RNA strand annealing activity;GO:0034057,RNA strand-exchange activity;GO:0003743,translation initiation factor activity	GO:0097010,eukaryotic translation initiation factor 4F complex assembly;GO:0001731,formation of translation preinitiation complex;GO:0006446,regulation of translational initiation;GO:0006413,translational initiation	hsa:1975,path:hsa03013,RNA transport;hsa:1975,path:hsa04151,PI3K-Akt signaling pathway;hsa:1975,path:hsa04150,mTOR signaling pathway;hsa:1975,path:hsa05205,Proteoglycans in cancer
FIP1_HUMAN	Q6UN15	FIP1L1	Pre-mRNA 3'-end-processing factor FIP1	0.028193341	0.026948605	0.191651986	2.55E-05	0.027570973	0.095838743	0.027570973	0.095838743	0.287680870355322	0.054835	0	3.47607402176195	0.055064	0	GO:0005829,cytosol;GO:0005847,mRNA cleavage and polyadenylation specificity factor complex;GO:0005654,nucleoplasm	GO:0003723,RNA binding	GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0006378,mRNA polyadenylation;GO:0000398,mRNA splicing, via spliceosome;GO:0098789,pre-mRNA cleavage required for polyadenylation;GO:0006369,termination of RNA polymerase II transcription	hsa:81608,path:hsa03015,mRNA surveillance pathway
KIME_HUMAN	Q03426	MVK	Mevalonate kinase	0.20094529	0.31476047	0.185685581	2.55E-05	0.25785288	0.0928555405	0.25785288	0.0928555405	2.77692508827731	0.151810	0	0.360110542492293	0.151241	0	GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0005777,peroxisome;GO:0005737,cytoplasm	GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0000287,magnesium ion binding;GO:0004496,mevalonate kinase activity;GO:0016301,kinase activity	GO:0006695,cholesterol biosynthetic process;GO:0019287,isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0008299,isoprenoid biosynthetic process;GO:0050728,negative regulation of inflammatory response;GO:0019216,regulation of lipid metabolic process	hsa:4598,path:hsa00900,Terpenoid backbone biosynthesis;hsa:4598,path:hsa04146,Peroxisome
RL38_HUMAN	P63173	RPL38	60S ribosomal protein L38	1.515221681	0.695556972	1.186405849	0.127877252	1.1053893265	0.6571415505	1.1053893265	0.6571415505	1.68211753717132	0.272197	0	0.594488778519972	0.271706	0	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0033291,eukaryotic 80S initiation complex;GO:0005925,focal adhesion;GO:0042788,polysomal ribosome;GO:0014069,postsynaptic density;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0034463,90S preribosome assembly;GO:0048318,axial mesoderm development;GO:0002181,cytoplasmic translation;GO:0042474,middle ear morphogenesis;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0001503,ossification;GO:0006417,regulation of translation;GO:0022618,ribonucleoprotein complex assembly;GO:0006364,rRNA processing;GO:0007605,sensory perception of sound;GO:0001501,skeletal system development;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6169,path:hsa03010,Ribosome
ABHDB_HUMAN	Q8NFV4	ABHD11	Protein ABHD11	0.101165742	0.13867395	0.146884815	0.15946146	0.119919846	0.1531731375	0.119919846	0.1531731375	0.782903895273412	0.472219	0	1.27729598235141	0.472341	0	GO:0005739,mitochondrion	GO:0016787,hydrolase activity		
ROA2_HUMAN	P22626	HNRNPA2B1	Heterogeneous nuclear ribonucleoproteins A2/B1	38.08189571	55.72774151	45.4717769	14.65396459	46.90481861	30.062870745	46.90481861	30.062870745	1.56022420506202	0.293641	0	0.640933525294364	0.293181	0	GO:0015030,Cajal body;GO:0071013,catalytic step 2 spliceosome;GO:0000781,chromosome, telomeric region;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0016363,nuclear matrix;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0005681,spliceosomal complex;GO:0005576,extracellular region	GO:0098505,G-rich strand telomeric DNA binding;GO:0042802,identical protein binding;GO:0035198,miRNA binding;GO:0003730,mRNA 3'-UTR binding;GO:1990247,N6-methyladenosine-containing RNA binding;GO:0097157,pre-mRNA intronic binding;GO:0003723,RNA binding;GO:0043047,single-stranded telomeric DNA binding	GO:0044806,G-quadruplex DNA unwinding;GO:0035722,interleukin-12-mediated signaling pathway;GO:1990428,miRNA transport;GO:0006406,mRNA export from nucleus;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0048025,negative regulation of mRNA splicing, via spliceosome;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:1905663,positive regulation of telomerase RNA reverse transcriptase activity;GO:1904358,positive regulation of telomere maintenance via telomere lengthening;GO:0031053,primary miRNA processing;GO:0016070,RNA metabolic process;GO:0050658,RNA transport;GO:0016032,viral process	
RAP2C_HUMAN	Q9Y3L5	RAP2C	Ras-related protein Rap-2c	0.352892294	2.633255575	0.219634287	0.158771111	1.4930739345	0.189202699	1.4930739345	0.189202699	7.89139870832392	0.028130	1	0.126720247824405	0.027848	-1	GO:0005923,bicellular tight junction;GO:0044291,cell-cell contact zone;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0070821,tertiary granule membrane;GO:0016020,membrane	GO:0003925,G protein activity;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0003713,transcription coactivator activity	GO:0090557,establishment of endothelial intestinal barrier;GO:0030336,negative regulation of cell migration;GO:0043312,neutrophil degranulation;GO:0031954,positive regulation of protein autophosphorylation;GO:0032486,Rap protein signal transduction;GO:0061097,regulation of protein tyrosine kinase activity;GO:0007165,signal transduction	hsa:57826,path:hsa04530,Tight junction
THTR_HUMAN	Q16762	TST	Thiosulfate sulfurtransferase	0.565252007	1.150144472	1.893459297	1.010542131	0.8576982395	1.452000714	0.8576982395	1.452000714	0.590700976404616	0.308470	0	1.69290392253393	0.308752	0	GO:0005615,extracellular space;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0008097,5S rRNA binding;GO:0004792,thiosulfate sulfurtransferase activity	GO:0009440,cyanate catabolic process;GO:0030855,epithelial cell differentiation;GO:0035928,rRNA import into mitochondrion;GO:0051029,rRNA transport;GO:0000098,sulfur amino acid catabolic process;GO:0019346,transsulfuration	hsa:7263,path:hsa00920,Sulfur metabolism;hsa:7263,path:hsa00270,Cysteine and methionine metabolism;hsa:7263,path:hsa04122,Sulfur relay system
OCAD2_HUMAN	Q56VL3	OCIAD2	OCIA domain-containing protein 2	0.897892526	0.801826792	0.041171728	0.089297818	0.849859659	0.065234773	0.849859659	0.065234773	13.0277093016021	0.009862	1	0.0767594652942575	0.009723	-1	GO:0005768,endosome;GO:0005794,Golgi apparatus;GO:0005764,lysosome		GO:0006897,endocytosis;GO:0061484,hematopoietic stem cell homeostasis;GO:0046427,positive regulation of receptor signaling pathway via JAK-STAT;GO:0009617,response to bacterium	
KCC2D_HUMAN	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	3.307884879	1.70269006	3.453949772	2.571151678	2.5052874695	3.012550725	2.5052874695	3.012550725	0.831616692362914	0.495038	0	1.20247706567631	0.494977	0	GO:0005954,calcium- and calmodulin-dependent protein kinase complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030666,endocytic vesicle membrane;GO:0016020,membrane;GO:0043005,neuron projection;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0042383,sarcolemma;GO:0033017,sarcoplasmic reticulum membrane	GO:0005524,ATP binding;GO:0005516,calmodulin binding;GO:0004683,calmodulin-dependent protein kinase activity;GO:0042802,identical protein binding;GO:0044325,ion channel binding;GO:0042803,protein homodimerization activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0019871,sodium channel inhibitor activity;GO:0031432,titin binding	GO:0086003,cardiac muscle cell contraction;GO:0071277,cellular response to calcium ion;GO:0032469,endoplasmic reticulum calcium ion homeostasis;GO:0060333,interferon-gamma-mediated signaling pathway;GO:1902306,negative regulation of sodium ion transmembrane transport;GO:2000650,negative regulation of sodium ion transmembrane transporter activity;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:0010666,positive regulation of cardiac muscle cell apoptotic process;GO:0010613,positive regulation of cardiac muscle hypertrophy;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:1902514,regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:0098901,regulation of cardiac muscle cell action potential;GO:0098909,regulation of cardiac muscle cell action potential involved in regulation of contraction;GO:0010881,regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0010649,regulation of cell communication by electrical coupling;GO:1901844,regulation of cell communication by electrical coupling involved in cardiac conduction;GO:0001558,regulation of cell growth;GO:0060341,regulation of cellular localization;GO:1900034,regulation of cellular response to heat;GO:0008016,regulation of heart contraction;GO:0086091,regulation of heart rate by cardiac conduction;GO:1901725,regulation of histone deacetylase activity;GO:0003254,regulation of membrane depolarization;GO:1901897,regulation of relaxation of cardiac muscle;GO:0010880,regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0060314,regulation of ryanodine-sensitive calcium-release channel activity;GO:0002026,regulation of the force of heart contraction;GO:0006357,regulation of transcription by RNA polymerase II;GO:0055119,relaxation of cardiac muscle	hsa:817,path:hsa04012,ErbB signaling pathway;hsa:817,path:hsa04310,Wnt signaling pathway;hsa:817,path:hsa04066,HIF-1 signaling pathway;hsa:817,path:hsa04020,Calcium signaling pathway;hsa:817,path:hsa04024,cAMP signaling pathway;hsa:817,path:hsa04114,Oocyte meiosis;hsa:817,path:hsa04217,Necroptosis;hsa:817,path:hsa04911,Insulin secretion;hsa:817,path:hsa04922,Glucagon signaling pathway;hsa:817,path:hsa04912,GnRH signaling pathway;hsa:817,path:hsa04921,Oxytocin signaling pathway;hsa:817,path:hsa04916,Melanogenesis;hsa:817,path:hsa04925,Aldosterone synthesis and secretion;hsa:817,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:817,path:hsa04971,Gastric acid secretion;hsa:817,path:hsa04725,Cholinergic synapse;hsa:817,path:hsa04728,Dopaminergic synapse;hsa:817,path:hsa04720,Long-term potentiation;hsa:817,path:hsa04722,Neurotrophin signaling pathway;hsa:817,path:hsa04740,Olfactory transduction;hsa:817,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:817,path:hsa04360,Axon guidance;hsa:817,path:hsa04713,Circadian entrainment;hsa:817,path:hsa05200,Pathways in cancer;hsa:817,path:hsa05205,Proteoglycans in cancer;hsa:817,path:hsa05214,Glioma;hsa:817,path:hsa05031,Amphetamine addiction;hsa:817,path:hsa04934,Cushing syndrome;hsa:817,path:hsa05152,Tuberculosis
CHP1_HUMAN	Q99653	CHP1	Calcineurin B homologous protein 1	0.235451581	0.671076799	0.04323846	0.002414573	0.45326419	0.0228265165	0.45326419	0.0228265165	19.8569146544984	0.003607	1	0.0503602909817341	0.003542	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0000139,Golgi membrane;GO:0015630,microtubule cytoskeleton;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0030133,transport vesicle	GO:0005509,calcium ion binding;GO:0048306,calcium-dependent protein binding;GO:0019900,kinase binding;GO:0008017,microtubule binding;GO:0015459,potassium channel regulator activity;GO:0004860,protein kinase inhibitor activity	GO:0071468,cellular response to acidic pH;GO:0031122,cytoplasmic microtubule organization;GO:0030214,hyaluronan catabolic process;GO:0022406,membrane docking;GO:0061025,membrane fusion;GO:0061024,membrane organization;GO:0001578,microtubule bundle formation;GO:0070885,negative regulation of calcineurin-NFAT signaling cascade;GO:0032088,negative regulation of NF-kappaB transcription factor activity;GO:0010923,negative regulation of phosphatase activity;GO:0031953,negative regulation of protein autophosphorylation;GO:0042308,negative regulation of protein import into nucleus;GO:0006469,negative regulation of protein kinase activity;GO:0001933,negative regulation of protein phosphorylation;GO:0031397,negative regulation of protein ubiquitination;GO:0071073,positive regulation of phospholipid biosynthetic process;GO:0060050,positive regulation of protein glycosylation;GO:0090314,positive regulation of protein targeting to membrane;GO:0051222,positive regulation of protein transport;GO:0032417,positive regulation of sodium;GO:0006813,potassium ion transport;GO:0051259,protein complex oligomerization;GO:0006611,protein export from nucleus;GO:0050821,protein stabilization;GO:0051453,regulation of intracellular pH;GO:1901214,regulation of neuron death;GO:0007264,small GTPase mediated signal transduction;GO:0006906,vesicle fusion;GO:0006903,vesicle targeting	
TEBP_HUMAN	Q15185	PTGES3	Prostaglandin E synthase 3	3.098681513	5.813002281	0.41078345	0.058453566	4.455841897	0.234618508	4.455841897	0.234618508	18.9918601690196	0.004034	1	0.0526541366196055	0.003962	-1	GO:0101031,chaperone complex;GO:0000781,chromosome, telomeric region;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0005697,telomerase holoenzyme complex	GO:0051087,chaperone binding;GO:0070182,DNA polymerase binding;GO:0051879,Hsp90 protein binding;GO:0050220,prostaglandin-E synthase activity;GO:0003720,telomerase activity;GO:0051082,unfolded protein binding	GO:0051085,chaperone cofactor-dependent protein refolding;GO:0051131,chaperone-mediated protein complex assembly;GO:0019371,cyclooxygenase pathway;GO:0042327,positive regulation of phosphorylation;GO:0051973,positive regulation of telomerase activity;GO:0001516,prostaglandin biosynthetic process;GO:0006457,protein folding;GO:0050821,protein stabilization;GO:1900034,regulation of cellular response to heat;GO:0007165,signal transduction;GO:1905323,telomerase holoenzyme complex assembly;GO:0000723,telomere maintenance;GO:0007004,telomere maintenance via telomerase;GO:0006805,xenobiotic metabolic process;GO:0008283,cell population proliferation;GO:0042921,glucocorticoid receptor signaling pathway;GO:0005978,glycogen biosynthetic process;GO:0060430,lung saccule development;GO:0043588,skin development	hsa:10728,path:hsa00590,Arachidonic acid metabolism
PLMN_HUMAN	P00747	PLG	Plasminogen	2.831179152	1.815160972	5.995450952	26.54667081	2.323170062	16.271060881	2.323170062	16.271060881	0.142779261843511	0.003789	-1	7.00381825125293	0.003827	1	GO:0072562,blood microparticle;GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0031232,extrinsic component of external side of plasma membrane;GO:0005886,plasma membrane;GO:0031093,platelet alpha granule lumen	GO:0034185,apolipoprotein binding;GO:0051087,chaperone binding;GO:0004175,endopeptidase activity;GO:0019899,enzyme binding;GO:0019900,kinase binding;GO:1990405,protein antigen binding;GO:0019904,protein domain specific binding;GO:0004252,serine-type endopeptidase activity;GO:0008236,serine-type peptidase activity;GO:0005102,signaling receptor binding	GO:0051702,biological process involved in interaction with symbiont;GO:0007596,blood coagulation;GO:0044267,cellular protein metabolic process;GO:0022617,extracellular matrix disassembly;GO:0042730,fibrinolysis;GO:0008285,negative regulation of cell population proliferation;GO:2000048,negative regulation of cell-cell adhesion mediated by cadherin;GO:0010812,negative regulation of cell-substrate adhesion;GO:0051918,negative regulation of fibrinolysis;GO:0002576,platelet degranulation;GO:0043536,positive regulation of blood vessel endothelial cell migration;GO:0051919,positive regulation of fibrinolysis;GO:0006508,proteolysis;GO:0048771,tissue remodeling	hsa:5340,path:hsa04080,Neuroactive ligand-receptor interaction;hsa:5340,path:hsa04610,Complement and coagulation cascades;hsa:5340,path:hsa05150,Staphylococcus aureus infection;hsa:5340,path:hsa05164,Influenza A
PSB9_HUMAN	P28065	PSMB9	Proteasome subunit beta type-9	4.218347875	5.65570979	1.057926672	0.388707579	4.9370288325	0.7233171255	4.9370288325	0.7233171255	6.82553842353343	0.036992	1	0.146508588472984	0.036661	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000502,proteasome complex;GO:0005839,proteasome core complex;GO:0019774,proteasome core complex, beta-subunit complex;GO:1990111,spermatoproteasome complex	GO:0004175,endopeptidase activity;GO:0004298,threonine-type endopeptidase activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:2000116,regulation of cysteine-type endopeptidase activity;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0002376,immune system process;GO:0051603,proteolysis involved in cellular protein catabolic process	hsa:5698,path:hsa03050,Proteasome
MTX2_HUMAN	O75431	MTX2	Metaxin-2	0.083723488	0.160266045	0.087904877	0.063188451	0.1219947665	0.075546664	0.1219947665	0.075546664	1.61482665204118	0.283738	0	0.619261515615918	0.283263	0	GO:0005737,cytoplasm;GO:0140275,MIB complex;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0001401,SAM complex		GO:0007007,inner mitochondrial membrane organization;GO:0006839,mitochondrial transport;GO:0007005,mitochondrion organization;GO:0015031,protein transport	
CD86_HUMAN	P42081	CD86	T-lymphocyte activation antigen CD86	0.138769228	0.12083843	0.248710891	0.633057302	0.129803829	0.4408840965	0.129803829	0.4408840965	0.294417126928506	0.058873	0	3.39654153422547	0.059111	0	GO:0009986,cell surface;GO:0034451,centriolar satellite;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005886,plasma membrane	GO:0015026,coreceptor activity;GO:0038023,signaling receptor activity;GO:0001618,virus receptor activity	GO:0007202,activation of phospholipase C activity;GO:1990051,activation of protein kinase C activity;GO:0002250,adaptive immune response;GO:0042113,B cell activation;GO:0023035,CD40 signaling pathway;GO:0007166,cell surface receptor signaling pathway;GO:0071222,cellular response to lipopolysaccharide;GO:0019221,cytokine-mediated signaling pathway;GO:0006955,immune response;GO:0042130,negative regulation of T cell proliferation;GO:0008284,positive regulation of cell population proliferation;GO:0002639,positive regulation of immunoglobulin production;GO:0032743,positive regulation of interleukin-2 production;GO:0032753,positive regulation of interleukin-4 production;GO:0032761,positive regulation of lymphotoxin A production;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:0051897,positive regulation of protein kinase B signaling;GO:0042102,positive regulation of T cell proliferation;GO:0045630,positive regulation of T-helper 2 cell differentiation;GO:0045893,positive regulation of transcription, DNA-templated;GO:0031295,T cell costimulation	hsa:942,path:hsa04514,Cell adhesion molecules (CAMs);hsa:942,path:hsa04620,Toll-like receptor signaling pathway;hsa:942,path:hsa04672,Intestinal immune network for IgA production;hsa:942,path:hsa05202,Transcriptional misregulation in cancer;hsa:942,path:hsa05322,Systemic lupus erythematosus;hsa:942,path:hsa05323,Rheumatoid arthritis;hsa:942,path:hsa05320,Autoimmune thyroid disease;hsa:942,path:hsa05330,Allograft rejection;hsa:942,path:hsa05332,Graft-versus-host disease;hsa:942,path:hsa05416,Viral myocarditis;hsa:942,path:hsa04940,Type I diabetes mellitus;hsa:942,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection
EIPR1_HUMAN	Q53HC9	EIPR1	EARP and GARP complex-interacting protein 1	0.060682688	0.086900993	2.55E-05	0.234773271	0.0737918405	0.1173993855	0.0737918405	0.1173993855	0.628553890514188	0.342639	0	1.59095348082557	0.342894	0	GO:0005802,trans-Golgi network;GO:0005794,Golgi apparatus		GO:0032456,endocytic recycling;GO:2001137,positive regulation of endocytic recycling;GO:1905281,positive regulation of retrograde transport, endosome to Golgi;GO:0016567,protein ubiquitination;GO:0050796,regulation of insulin secretion	
ABCBA_HUMAN	Q9NRK6	ABCB10	ATP-binding cassette sub-family B member 10, mitochondrial	0.040668446	0.023054041	0.045547036	0.033802062	0.0318612435	0.039674549	0.0318612435	0.039674549	0.803065045553511	0.487700	0	1.24522914493278	0.487804	0	GO:0032592,integral component of mitochondrial membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0042626,ATPase-coupled transmembrane transporter activity;GO:0042802,identical protein binding	GO:0006839,mitochondrial transport	hsa:23456,path:hsa02010,ABC transporters
PLAK_HUMAN	P14923	JUP	Junction plakoglobin	10.15913035	8.67689785	7.122340105	7.710517917	9.4180141	7.416429011	9.4180141	7.416429011	1.26988528927214	0.355978	0	0.787472702021119	0.355624	0	GO:0015629,actin cytoskeleton;GO:0005912,adherens junction;GO:0016327,apicolateral plasma membrane;GO:0016342,catenin complex;GO:0005911,cell-cell junction;GO:0001533,cornified envelope;GO:0005737,cytoplasm;GO:0009898,cytoplasmic side of plasma membrane;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0030057,desmosome;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005916,fascia adherens;GO:1904813,ficolin-1-rich granule lumen;GO:0005925,focal adhesion;GO:0071665,gamma-catenin-TCF7L2 complex;GO:0014704,intercalated disc;GO:0005882,intermediate filament;GO:0016328,lateral plasma membrane;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0032993,protein-DNA complex;GO:0035580,specific granule lumen;GO:0030018,Z disc;GO:0005915,zonula adherens	GO:0045294,alpha-catenin binding;GO:0045296,cadherin binding;GO:0050839,cell adhesion molecule binding;GO:0086083,cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication;GO:0106006,cytoskeletal protein-membrane anchor activity;GO:0035257,nuclear hormone receptor binding;GO:0042803,protein homodimerization activity;GO:0019901,protein kinase binding;GO:0019903,protein phosphatase binding;GO:0044877,protein-containing complex binding;GO:0005198,structural molecule activity;GO:0003713,transcription coactivator activity	GO:0034332,adherens junction organization;GO:0086073,bundle of His cell-Purkinje myocyte adhesion involved in cell communication;GO:0016477,cell migration;GO:0098609,cell-cell adhesion;GO:0071681,cellular response to indole-3-methanol;GO:0070268,cornification;GO:0002159,desmosome assembly;GO:0050982,detection of mechanical stimulus;GO:0071603,endothelial cell-cell adhesion;GO:0031424,keratinization;GO:0043537,negative regulation of blood vessel endothelial cell migration;GO:0043312,neutrophil degranulation;GO:0045766,positive regulation of angiogenesis;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0001954,positive regulation of cell-matrix adhesion;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0042307,positive regulation of protein import into nucleus;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0072659,protein localization to plasma membrane;GO:0042127,regulation of cell population proliferation;GO:0086091,regulation of heart rate by cardiac conduction;GO:0098911,regulation of ventricular cardiac muscle cell action potential;GO:0007155,cell adhesion	hsa:3728,path:hsa05200,Pathways in cancer;hsa:3728,path:hsa05202,Transcriptional misregulation in cancer;hsa:3728,path:hsa05226,Gastric cancer;hsa:3728,path:hsa05221,Acute myeloid leukemia;hsa:3728,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC)
CYRIA_HUMAN	Q9H0Q0	CYRIA	CYFIP-related Rac1 interactor A	2.55E-05	0.015367774	0.058468801	2.55E-05	0.007696637	0.0292471505	0.007696637	0.0292471505	0.26315852547755	0.041296	-1	3.799990892126	0.041493	1	GO:0016020,membrane	GO:0031267,small GTPase binding	GO:0030833,regulation of actin filament polymerization	
PROF2_HUMAN	P35080	PFN2	Profilin-2	1.081117685	1.59946865	0.406535501	0.48633525	1.3402931675	0.4464353755	1.3402931675	0.4464353755	3.00221093814283	0.136879	0	0.33308785445256	0.136317	0	GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0016021,integral component of membrane;GO:0098794,postsynapse;GO:0098793,presynapse;GO:0098685,Schaffer collateral - CA1 synapse	GO:0003779,actin binding;GO:0003785,actin monomer binding;GO:0016887,ATPase activity;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding	GO:0030036,actin cytoskeleton organization;GO:0030837,negative regulation of actin filament polymerization;GO:0010633,negative regulation of epithelial cell migration;GO:1900028,negative regulation of ruffle assembly;GO:0032233,positive regulation of actin filament bundle assembly;GO:0030838,positive regulation of actin filament polymerization;GO:0032781,positive regulation of ATPase activity;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0051496,positive regulation of stress fiber assembly;GO:0050821,protein stabilization;GO:0030833,regulation of actin filament polymerization;GO:0098885,modification of postsynaptic actin cytoskeleton;GO:2000300,regulation of synaptic vesicle exocytosis	hsa:5217,path:hsa04015,Rap1 signaling pathway;hsa:5217,path:hsa04810,Regulation of actin cytoskeleton;hsa:5217,path:hsa05132,Salmonella infection;hsa:5217,path:hsa05131,Shigellosis
ARHG6_HUMAN	Q15052	ARHGEF6	Rho guanine nucleotide exchange factor 6	0.053909295	0.047326008	0.094461999	0.122045479	0.0506176515	0.108253739	0.0506176515	0.108253739	0.467583401437986	0.195616	0	2.13865589951363	0.195951	0	GO:0005829,cytosol;GO:0030027,lamellipodium	GO:0005096,GTPase activator activity;GO:0005085,guanyl-nucleotide exchange factor activity	GO:0006915,apoptotic process;GO:0007186,G protein-coupled receptor signaling pathway;GO:0007254,JNK cascade;GO:0030032,lamellipodium assembly;GO:0043065,positive regulation of apoptotic process;GO:0051056,regulation of small GTPase mediated signal transduction	hsa:9459,path:hsa04810,Regulation of actin cytoskeleton;hsa:9459,path:hsa05212,Pancreatic cancer
C1TM_HUMAN	Q6UB35	MTHFD1L	Monofunctional C1-tetrahydrofolate synthase, mitochondrial	0.061420049	0.022607073	0.046015667	0.034419799	0.042013561	0.040217733	0.042013561	0.040217733	1.04465264116205	0.418916	0	0.957255991702298	0.418688	0	GO:0005829,cytosol;GO:0016020,membrane;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0004329,formate-tetrahydrofolate ligase activity;GO:0004488,methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0042803,protein homodimerization activity	GO:0009257,10-formyltetrahydrofolate biosynthetic process;GO:0048702,embryonic neurocranium morphogenesis;GO:0048703,embryonic viscerocranium morphogenesis;GO:0046655,folic acid metabolic process;GO:0006760,folic acid-containing compound metabolic process;GO:0015942,formate metabolic process;GO:0001843,neural tube closure;GO:0035999,tetrahydrofolate interconversion;GO:0006730,one-carbon metabolic process	hsa:25902,path:hsa00670,One carbon pool by folate
COPD_HUMAN	P48444	ARCN1	Coatomer subunit delta	7.565863401	10.6634372	7.880598984	5.793281789	9.1146503005	6.8369403865	9.1146503005	6.8369403865	1.33314754630558	0.340827	0	0.750104519766924	0.340445	0	GO:0030126,COPI vesicle coat;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0000139,Golgi membrane;GO:0016020,membrane;GO:0030133,transport vesicle;GO:0005783,endoplasmic reticulum	GO:0003723,RNA binding	GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0051645,Golgi localization;GO:0006886,intracellular protein transport;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0015031,protein transport;GO:0008344,adult locomotory behavior;GO:0021691,cerebellar Purkinje cell layer maturation;GO:0043473,pigmentation	
RAB6D_HUMAN	Q53S08	RAB6D	Ras-related protein Rab-6D	0.042228274	0.073709936	2.55E-05	2.55E-05	0.057969105	2.55e-005	0.057969105	2.55e-005	2273.29823529412	0.000000	1	0.000439889489409919	0.000000	-1	GO:0005829,cytosol;GO:0012505,endomembrane system;GO:0005794,Golgi apparatus	GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0006891,intra-Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0042147,retrograde transport, endosome to Golgi;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	
SYNE3_HUMAN	Q6ZMZ3	SYNE3	Nesprin-3	0.334625762	0.086159234	0.129857501	0.305604634	0.210392498	0.2177310675	0.210392498	0.2177310675	0.966295257795491	0.444745	0	1.03488037629555	0.444572	0	GO:0005737,cytoplasm;GO:0016021,integral component of membrane;GO:0034993,meiotic nuclear membrane microtubule tethering complex;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0005640,nuclear outer membrane;GO:0005791,rough endoplasmic reticulum	GO:0051015,actin filament binding;GO:0140444,cytoskeleton-nuclear membrane anchor activity;GO:0008092,cytoskeletal protein binding	GO:0007010,cytoskeleton organization;GO:0090150,establishment of protein localization to membrane;GO:0007097,nuclear migration;GO:0008360,regulation of cell shape	
NCF1B_HUMAN	A6NI72	NCF1B	Putative neutrophil cytosol factor 1B	0.455127623	0.625981384	0.4033512	0.363314973	0.5405545035	0.3833330865	0.5405545035	0.3833330865	1.41014309105301	0.323644	0	0.709147891688965	0.323232	0	GO:0005737,cytoplasm	GO:0060090,molecular adaptor activity;GO:0035091,phosphatidylinositol binding;GO:0016175,superoxide-generating NAD(P)H oxidase activity;GO:0016176,superoxide-generating NADPH oxidase activator activity	GO:0045730,respiratory burst;GO:0006801,superoxide metabolic process	
ERAP1_HUMAN	Q9NZ08	ERAP1	Endoplasmic reticulum aminopeptidase 1	7.59753601	7.076299728	12.33055766	8.733016289	7.336917869	10.5317869745	7.336917869	10.5317869745	0.696645107498324	0.402033	0	1.43545112028567	0.402231	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0004177,aminopeptidase activity;GO:0005151,interleukin-1, type II receptor binding;GO:0005138,interleukin-6 receptor binding;GO:0070006,metalloaminopeptidase activity;GO:0008235,metalloexopeptidase activity;GO:0042277,peptide binding;GO:0008270,zinc ion binding	GO:0002250,adaptive immune response;GO:0001525,angiogenesis;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0045444,fat cell differentiation;GO:0006509,membrane protein ectodomain proteolysis;GO:0043171,peptide catabolic process;GO:0006508,proteolysis;GO:0008217,regulation of blood pressure;GO:0045088,regulation of innate immune response;GO:0009617,response to bacterium;GO:0007165,signal transduction	
AXA81_HUMAN	Q5VT79	ANXA8L1	Annexin A8-like protein 1	2.239744449	1.433234357	2.360615135	2.57655959	1.836489403	2.4685873625	1.836489403	2.4685873625	0.743943451586069	0.441289	0	1.34418818778232	0.441446	0	GO:0005737,cytoplasm	GO:0005509,calcium ion binding;GO:0005544,calcium-dependent phospholipid binding	GO:0016197,endosomal transport;GO:0007032,endosome organization;GO:1900138,negative regulation of phospholipase A2 activity;GO:1900004,negative regulation of serine-type endopeptidase activity	
GLSK_HUMAN	O94925	GLS	Glutaminase kidney isoform, mitochondrial	3.847171006	2.545314542	3.797523815	3.047063053	3.196242774	3.422293434	3.196242774	3.422293434	0.933947610174447	0.456105	0	1.07072387048907	0.455957	0	GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0045202,synapse	GO:0004359,glutaminase activity	GO:0007268,chemical synaptic transmission;GO:0006537,glutamate biosynthetic process;GO:0090461,glutamate homeostasis;GO:0006543,glutamine catabolic process;GO:0009064,glutamine family amino acid metabolic process;GO:0006836,neurotransmitter transport;GO:0051289,protein homotetramerization;GO:0002087,regulation of respiratory gaseous exchange by nervous system process;GO:0001967,suckling behavior;GO:0006541,glutamine metabolic process	hsa:2744,path:hsa00250,Alanine, aspartate and glutamate metabolism;hsa:2744,path:hsa00220,Arginine biosynthesis;hsa:2744,path:hsa00471,D-Glutamine and D-glutamate metabolism;hsa:2744,path:hsa04964,Proximal tubule bicarbonate reclamation;hsa:2744,path:hsa04724,Glutamatergic synapse;hsa:2744,path:hsa04727,GABAergic synapse;hsa:2744,path:hsa05206,MicroRNAs in cancer;hsa:2744,path:hsa05230,Central carbon metabolism in cancer
PIGS_HUMAN	Q96S52	PIGS	GPI transamidase component PIG-S	0.05246586	0.089502381	0.282956024	0.121935086	0.0709841205	0.202445555	0.0709841205	0.202445555	0.35063313936431	0.097270	0	2.85198370528518	0.097566	0	GO:0005789,endoplasmic reticulum membrane;GO:0042765,GPI-anchor transamidase complex;GO:0016020,membrane		GO:0016255,attachment of GPI anchor to protein	hsa:94005,path:hsa00563,Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
TXND5_HUMAN	Q8NBS9	TXNDC5	Thioredoxin domain-containing protein 5	17.03291235	7.038512244	29.52537026	10.78275328	12.035712297	20.15406177	12.035712297	20.15406177	0.597185442535239	0.314368	0	1.67452172938893	0.314646	0	GO:0035578,azurophil granule lumen;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0043202,lysosomal lumen	GO:0003756,protein disulfide isomerase activity	GO:0043277,apoptotic cell clearance;GO:0043066,negative regulation of apoptotic process;GO:0043312,neutrophil degranulation;GO:0006892,post-Golgi vesicle-mediated transport	hsa:81567,path:hsa04141,Protein processing in endoplasmic reticulum
RL11_HUMAN	P62913	RPL11	60S ribosomal protein L11	10.52105322	16.33510663	2.036309161	1.599804632	13.428079925	1.8180568965	13.428079925	1.8180568965	7.3859514247606	0.031925	1	0.135392171230318	0.031621	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0042788,polysomal ribosome;GO:0032991,protein-containing complex;GO:0005840,ribosome	GO:0008097,5S rRNA binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome;GO:1990948,ubiquitin ligase inhibitor activity;GO:0031625,ubiquitin protein ligase binding	GO:0002181,cytoplasmic translation;GO:0032435,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:2000435,negative regulation of protein neddylation;GO:1904667,negative regulation of ubiquitin protein ligase activity;GO:2000059,negative regulation of ubiquitin-dependent protein catabolic process;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0010628,positive regulation of gene expression;GO:1902255,positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:0032092,positive regulation of protein binding;GO:0034504,protein localization to nucleus;GO:0050821,protein stabilization;GO:0006605,protein targeting;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0000027,ribosomal large subunit assembly;GO:0042273,ribosomal large subunit biogenesis;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6135,path:hsa03010,Ribosome
RS23_HUMAN	P62266	RPS23	40S ribosomal protein S23	4.624020186	1.621484618	0.590055925	0.471817807	3.122752402	0.530936866	3.122752402	0.530936866	5.88158894583146	0.048331	1	0.170022082333507	0.047947	-1	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0005783,endoplasmic reticulum;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0042788,polysomal ribosome;GO:0005840,ribosome;GO:0005791,rough endoplasmic reticulum;GO:0015935,small ribosomal subunit	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:1990145,maintenance of translational fidelity;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0034063,stress granule assembly;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6228,path:hsa03010,Ribosome
PLCC_HUMAN	Q9NRZ7	AGPAT3	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma	0.089486162	0.09918786	0.12808079	0.029318747	0.094337011	0.0786997685	0.094337011	0.0786997685	1.19869489832108	0.374255	0	0.834240640717353	0.373937	0	GO:0012505,endomembrane system;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0005886,plasma membrane	GO:0003841,1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0016746,transferase activity, transferring acyl groups	GO:0016024,CDP-diacylglycerol biosynthetic process;GO:0006654,phosphatidic acid biosynthetic process;GO:0008654,phospholipid biosynthetic process	hsa:56894,path:hsa00561,Glycerolipid metabolism;hsa:56894,path:hsa00564,Glycerophospholipid metabolism;hsa:56894,path:hsa04072,Phospholipase D signaling pathway
SKIV2_HUMAN	Q15477	SKIV2L	Helicase SKI2W	0.586340479	0.309773158	0.623148264	0.504195878	0.4480568185	0.563672071	0.4480568185	0.563672071	0.794889159055035	0.481466	0	1.25803703397943	0.481577	0	GO:0005829,cytosol;GO:0005634,nucleus;GO:0055087,Ski complex	GO:0005524,ATP binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0004386,helicase activity;GO:0016787,hydrolase activity	GO:0043928,exonucleolytic catabolism of deadenylated mRNA;GO:0070478,nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay;GO:0006401,RNA catabolic process	hsa:6499,path:hsa03018,RNA degradation
MATR3_HUMAN	P43243	MATR3	Matrin-3	6.87792821	3.357897808	7.640465641	4.242212205	5.117913009	5.941338923	5.117913009	5.941338923	0.861407348634435	0.483208	0	1.16089095546407	0.483120	0	GO:0016020,membrane;GO:0005637,nuclear inner membrane;GO:0016363,nuclear matrix;GO:0005634,nucleus	GO:0042802,identical protein binding;GO:0035198,miRNA binding;GO:0003723,RNA binding;GO:0005198,structural molecule activity;GO:0008270,zinc ion binding;GO:0003676,nucleic acid binding	GO:0002218,activation of innate immune response;GO:0003170,heart valve development;GO:0045087,innate immune response;GO:0010608,posttranscriptional regulation of gene expression;GO:0003281,ventricular septum development	
NU107_HUMAN	P57740	NUP107	Nuclear pore complex protein Nup107	0.335316262	0.291396118	0.245601695	0.373572906	0.31335619	0.3095873005	0.31335619	0.3095873005	1.01217391506019	0.429343	0	0.987972506622576	0.429137	0	GO:0000777,condensed chromosome kinetochore;GO:0005829,cytosol;GO:0043657,host cell;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0034399,nuclear periphery;GO:0005643,nuclear pore;GO:0031080,nuclear pore outer ring	GO:0017056,structural constituent of nuclear pore	GO:0008585,female gonad development;GO:0075733,intracellular transport of virus;GO:0007084,mitotic nuclear envelope reassembly;GO:0007052,mitotic spindle organization;GO:0006406,mRNA export from nucleus;GO:0072006,nephron development;GO:0051292,nuclear pore complex assembly;GO:0000973,posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery;GO:0006606,protein import into nucleus;GO:0016925,protein sumoylation;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0006355,regulation of transcription, DNA-templated;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription	hsa:57122,path:hsa03013,RNA transport
RUVB1_HUMAN	Q9Y265	RUVBL1	RuvB-like 1	2.274847215	2.627738159	4.54972492	3.366319764	2.451292687	3.958022342	2.451292687	3.958022342	0.619322599821747	0.334368	0	1.61466738059909	0.334630	0	GO:0005829,cytosol;GO:0120293,dynein axonemal particle;GO:0070062,extracellular exosome;GO:0031011,Ino80 complex;GO:0016020,membrane;GO:0005815,microtubule organizing center;GO:0071339,MLL1 complex;GO:0035267,NuA4 histone acetyltransferase complex;GO:0016363,nuclear matrix;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0097255,R2TP complex;GO:1990904,ribonucleoprotein complex;GO:0000812,Swr1 complex	GO:0043139,5'-3' DNA helicase activity;GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0051117,ATPase binding;GO:0045296,cadherin binding;GO:0003678,DNA helicase activity;GO:0017025,TBP-class protein binding;GO:0001094,TFIID-class transcription factor complex binding;GO:0003713,transcription coactivator activity;GO:0016787,hydrolase activity	GO:1904837,beta-catenin-TCF complex assembly;GO:0000492,box C/D snoRNP assembly;GO:0007049,cell cycle;GO:0051301,cell division;GO:0034080,CENP-A containing nucleosome assembly;GO:0006338,chromatin remodeling;GO:0006310,DNA recombination;GO:0006281,DNA repair;GO:0016573,histone acetylation;GO:0043968,histone H2A acetylation;GO:0043967,histone H4 acetylation;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:1904874,positive regulation of telomerase RNA localization to Cajal body;GO:0016579,protein deubiquitination;GO:0040008,regulation of growth;GO:0006357,regulation of transcription by RNA polymerase II;GO:0007283,spermatogenesis	hsa:8607,path:hsa04310,Wnt signaling pathway
SAFB2_HUMAN	Q14151	SAFB2	Scaffold attachment factor B2	0.271680365	0.091664101	0.24988675	0.229436905	0.181672233	0.2396618275	0.181672233	0.2396618275	0.758035749351865	0.452628	0	1.31919899668982	0.452773	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0042802,identical protein binding;GO:0003723,RNA binding;GO:0043565,sequence-specific DNA binding	GO:0060765,regulation of androgen receptor signaling pathway;GO:0050684,regulation of mRNA processing;GO:0006357,regulation of transcription by RNA polymerase II;GO:0060008,Sertoli cell differentiation;GO:0006355,regulation of transcription, DNA-templated	
GSTM1_HUMAN	P09488	GSTM1	Glutathione S-transferase Mu 1	0.035699186	0.679364014	0.396963705	2.55E-05	0.3575316	0.1984946025	0.3575316	0.1984946025	1.8012157282715	0.253396	0	0.555180584037887	0.252882	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0045171,intercellular bridge	GO:0019899,enzyme binding;GO:0043295,glutathione binding;GO:0004364,glutathione transferase activity;GO:0042803,protein homodimerization activity	GO:0070458,cellular detoxification of nitrogen compound;GO:1901687,glutathione derivative biosynthetic process;GO:0006749,glutathione metabolic process;GO:0051122,hepoxilin biosynthetic process;GO:0018916,nitrobenzene metabolic process;GO:0006693,prostaglandin metabolic process;GO:0042178,xenobiotic catabolic process	hsa:2944,path:hsa00480,Glutathione metabolism;hsa:2944,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:2944,path:hsa00982,Drug metabolism - cytochrome P450;hsa:2944,path:hsa00983,Drug metabolism - other enzymes;hsa:2944,path:hsa05200,Pathways in cancer;hsa:2944,path:hsa05204,Chemical carcinogenesis;hsa:2944,path:hsa05225,Hepatocellular carcinoma;hsa:2944,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:2944,path:hsa01524,Platinum drug resistance
FMOD_HUMAN	Q06828	FMOD	Fibromodulin	0.640172802	0.265432137	0.293173585	0.886107458	0.4528024695	0.5896405215	0.4528024695	0.5896405215	0.767929701215421	0.460487	0	1.30220253028015	0.460623	0	GO:0062023,collagen-containing extracellular matrix;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005796,Golgi lumen;GO:0043202,lysosomal lumen		GO:0030199,collagen fibril organization;GO:0018146,keratan sulfate biosynthetic process;GO:0042340,keratan sulfate catabolic process;GO:0007181,transforming growth factor beta receptor complex assembly	hsa:2331,path:hsa04350,TGF-beta signaling pathway
IF2B3_HUMAN	O00425	IGF2BP3	Insulin-like growth factor 2 mRNA-binding protein 3	0.065188943	0.035442362	0.106755633	0.144979517	0.0503156525	0.125867575	0.0503156525	0.125867575	0.399750710220643	0.136340	0	2.50155903274831	0.136665	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus	GO:0003730,mRNA 3'-UTR binding;GO:0048027,mRNA 5'-UTR binding;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0045182,translation regulator activity	GO:0009653,anatomical structure morphogenesis;GO:0051028,mRNA transport;GO:0017148,negative regulation of translation;GO:0007399,nervous system development;GO:0001817,regulation of cytokine production;GO:0010468,regulation of gene expression;GO:0043488,regulation of mRNA stability;GO:0051252,regulation of RNA metabolic process;GO:0006412,translation	
TENS3_HUMAN	Q68CZ2	TNS3	Tensin-3	0.406068549	0.676314765	0.527249251	0.62642954	0.541191657	0.5768393955	0.541191657	0.5768393955	0.938201622881356	0.454586	0	1.06586897273621	0.454436	0	GO:0005829,cytosol;GO:0005925,focal adhesion		GO:0035556,intracellular signal transduction	
ISOC2_HUMAN	Q96AB3	ISOC2	Isochorismatase domain-containing protein 2	0.293631153	0.722361238	0.083561122	2.55E-05	0.5079961955	0.041793311	0.5079961955	0.041793311	12.1549641161477	0.011510	1	0.0822709133852165	0.011354	-1	GO:0005737,cytoplasm;GO:0005634,nucleus		GO:0031648,protein destabilization	
TXTP_HUMAN	P53007	SLC25A1	Tricarboxylate transport protein, mitochondrial	5.344747735	4.728088517	2.856884036	8.96411017	5.036418126	5.910497103	5.036418126	5.910497103	0.852114134941993	0.486853	0	1.17355170979305	0.486773	0	GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005634,nucleus	GO:0071913,citrate secondary active transmembrane transporter activity;GO:0015137,citrate transmembrane transporter activity	GO:0046949,fatty-acyl-CoA biosynthetic process;GO:0006094,gluconeogenesis;GO:0006843,mitochondrial citrate transmembrane transport	
DUT_HUMAN	P33316	DUT	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial	3.058211677	2.173497679	0.279948072	0.088024281	2.615854678	0.1839861765	2.615854678	0.1839861765	14.2176696519371	0.008081	1	0.0703350144208584	0.007961	-1	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0004170,dUTP diphosphatase activity;GO:0042802,identical protein binding;GO:0000287,magnesium ion binding;GO:0042975,peroxisome proliferator activated receptor binding;GO:0032556,pyrimidine deoxyribonucleotide binding;GO:0003723,RNA binding;GO:0030547,signaling receptor inhibitor activity	GO:0006260,DNA replication;GO:0006226,dUMP biosynthetic process;GO:0046081,dUTP catabolic process;GO:0001889,liver development;GO:0006139,nucleobase-containing compound metabolic process;GO:0015949,nucleobase-containing small molecule interconversion;GO:0043254,regulation of protein-containing complex assembly;GO:0014070,response to organic cyclic compound	hsa:1854,path:hsa00240,Pyrimidine metabolism;hsa:1854,path:hsa00983,Drug metabolism - other enzymes
SDHA_HUMAN	P31040	SDHA	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	4.250351461	4.113226018	4.47554599	4.093841302	4.1817887395	4.284693646	4.1817887395	4.284693646	0.975983135551344	0.441424	0	1.02460786828564	0.441245	0	GO:0005743,mitochondrial inner membrane;GO:0005749,mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone);GO:0005739,mitochondrion;GO:0005730,nucleolus	GO:0009055,electron transfer activity;GO:0050660,flavin adenine dinucleotide binding;GO:0008177,succinate dehydrogenase (ubiquinone) activity;GO:0016491,oxidoreductase activity	GO:0006121,mitochondrial electron transport, succinate to ubiquinone;GO:0007399,nervous system development;GO:0022904,respiratory electron transport chain;GO:0006105,succinate metabolic process;GO:0006099,tricarboxylic acid cycle;GO:0022900,electron transport chain	hsa:6389,path:hsa00020,Citrate cycle (TCA cycle);hsa:6389,path:hsa00190,Oxidative phosphorylation;hsa:6389,path:hsa04714,Thermogenesis;hsa:6389,path:hsa05010,Alzheimer disease;hsa:6389,path:hsa05012,Parkinson disease;hsa:6389,path:hsa05016,Huntington disease;hsa:6389,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
COG4_HUMAN	Q9H9E3	COG4	Conserved oligomeric Golgi complex subunit 4	0.11550822	0.108150363	0.180102562	0.111552346	0.1118292915	0.145827454	0.1118292915	0.145827454	0.766860343731983	0.459642	0	1.30401840201232	0.459778	0	GO:0005829,cytosol;GO:0000139,Golgi membrane;GO:0017119,Golgi transport complex;GO:0032588,trans-Golgi network membrane	GO:0042802,identical protein binding	GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030,Golgi organization;GO:0048213,Golgi vesicle prefusion complex stabilization;GO:0015031,protein transport;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	
GSLG1_HUMAN	Q92896	GLG1	Golgi apparatus protein 1	1.283375274	1.62555982	1.46073821	0.770872324	1.454467547	1.115805267	1.454467547	1.115805267	1.30351378508056	0.347802	0	0.767157211105515	0.347433	0	GO:0005856,cytoskeleton;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0017134,fibroblast growth factor binding;GO:0005102,signaling receptor binding	GO:0060349,bone morphogenesis;GO:0050900,leukocyte migration;GO:0010955,negative regulation of protein processing;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0032330,regulation of chondrocyte differentiation	hsa:2734,path:hsa04514,Cell adhesion molecules (CAMs)
RS3_HUMAN	P23396	RPS3	40S ribosomal protein S3	19.48647975	30.88749871	20.57521804	12.37473838	25.18698923	16.47497821	25.18698923	16.47497821	1.5288025822524	0.299572	0	0.654106692132015	0.299121	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0072686,mitotic spindle;GO:0071159,NF-kappaB complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0005844,polysome;GO:0014069,postsynaptic density;GO:1990904,ribonucleoprotein complex;GO:0005840,ribosome;GO:0032587,ruffle membrane;GO:0015935,small ribosomal subunit;GO:0005819,spindle	GO:0140078,class I DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0003684,damaged DNA binding;GO:0003677,DNA binding;GO:0003906,DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0004520,endodeoxyribonuclease activity;GO:0019899,enzyme binding;GO:0030544,Hsp70 protein binding;GO:0051879,Hsp90 protein binding;GO:0051536,iron-sulfur cluster binding;GO:0019900,kinase binding;GO:0008017,microtubule binding;GO:0003729,mRNA binding;GO:0032357,oxidized purine DNA binding;GO:0032358,oxidized pyrimidine DNA binding;GO:0051018,protein kinase A binding;GO:0019901,protein kinase binding;GO:0044877,protein-containing complex binding;GO:0003723,RNA binding;GO:0070181,small ribosomal subunit rRNA binding;GO:0003735,structural constituent of ribosome;GO:0097100,supercoiled DNA binding;GO:0008134,transcription factor binding;GO:0015631,tubulin binding;GO:0044390,ubiquitin-like protein conjugating enzyme binding	GO:0006915,apoptotic process;GO:0051301,cell division;GO:0006974,cellular response to DNA damage stimulus;GO:0070301,cellular response to hydrogen peroxide;GO:0034614,cellular response to reactive oxygen species;GO:0071356,cellular response to tumor necrosis factor;GO:0007059,chromosome segregation;GO:0002181,cytoplasmic translation;GO:0042769,DNA damage response, detection of DNA damage;GO:0006281,DNA repair;GO:0045738,negative regulation of DNA repair;GO:0031397,negative regulation of protein ubiquitination;GO:0017148,negative regulation of translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0042104,positive regulation of activated T cell proliferation;GO:2001235,positive regulation of apoptotic signaling pathway;GO:1905053,positive regulation of base-excision repair;GO:2001272,positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis;GO:1902546,positive regulation of DNA N-glycosylase activity;GO:0045739,positive regulation of DNA repair;GO:0032079,positive regulation of endodeoxyribonuclease activity;GO:0010628,positive regulation of gene expression;GO:0032743,positive regulation of interleukin-2 production;GO:1902231,positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0043507,positive regulation of JUN kinase activity;GO:0031116,positive regulation of microtubule polymerization;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:0031334,positive regulation of protein-containing complex assembly;GO:0050862,positive regulation of T cell receptor signaling pathway;GO:0042981,regulation of apoptotic process;GO:0061481,response to TNF agonist;GO:0051225,spindle assembly;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription;GO:0006417,regulation of translation	hsa:6188,path:hsa03010,Ribosome;hsa:6188,path:hsa05130,Pathogenic Escherichia coli infection;hsa:6188,path:hsa05132,Salmonella infection
STK3_HUMAN	Q13188	STK3	Serine/threonine-protein kinase 3	0.430597857	0.678367646	0.580007866	0.834902479	0.5544827515	0.7074551725	0.5544827515	0.7074551725	0.783770863587827	0.472892	0	1.27588310111753	0.473014	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0000287,magnesium ion binding;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0043539,protein serine/threonine kinase activator activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity	GO:0032147,activation of protein kinase activity;GO:0006915,apoptotic process;GO:0060706,cell differentiation involved in embryonic placenta development;GO:0007417,central nervous system development;GO:0003157,endocardium development;GO:0097284,hepatocyte apoptotic process;GO:0035329,hippo signaling;GO:0035556,intracellular signal transduction;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0008285,negative regulation of cell population proliferation;GO:0046621,negative regulation of organ growth;GO:0001841,neural tube formation;GO:0043065,positive regulation of apoptotic process;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:1902043,positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0045600,positive regulation of fat cell differentiation;GO:0046330,positive regulation of JNK cascade;GO:0032092,positive regulation of protein binding;GO:0051897,positive regulation of protein kinase B signaling;GO:0060215,primitive hemopoiesis;GO:0006468,protein phosphorylation;GO:0050821,protein stabilization;GO:0060800,regulation of cell differentiation involved in embryonic placenta development;GO:0007165,signal transduction;GO:0031098,stress-activated protein kinase signaling cascade	hsa:6788,path:hsa04010,MAPK signaling pathway;hsa:6788,path:hsa04390,Hippo signaling pathway;hsa:6788,path:hsa04392,Hippo signaling pathway - multiple species
DC1I2_HUMAN	Q13409	DYNC1I2	Cytoplasmic dynein 1 intermediate chain 2	0.450100728	0.530563329	1.590454219	0.560243572	0.4903320285	1.0753488955	0.4903320285	1.0753488955	0.455974828775932	0.185179	0	2.19310351557016	0.185514	0	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005868,cytoplasmic dynein complex;GO:0005829,cytosol;GO:0005874,microtubule;GO:0031982,vesicle	GO:0045504,dynein heavy chain binding;GO:0045503,dynein light chain binding;GO:0003777,microtubule motor activity	GO:0035973,aggrephagy;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0097711,ciliary basal body-plasma membrane docking;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0000086,G2/M transition of mitotic cell cycle;GO:0007018,microtubule-based movement;GO:0007052,mitotic spindle organization;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0010970,transport along microtubule;GO:0019058,viral life cycle	hsa:1781,path:hsa04145,Phagosome;hsa:1781,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:1781,path:hsa05132,Salmonella infection
GHITM_HUMAN	Q9H3K2	GHITM	Growth hormone-inducible transmembrane protein	1.291720261	2.346104843	2.653854308	71.59127213	1.818912552	37.122563219	1.818912552	37.122563219	0.0489974935531674	0.000008	-1	20.4092072365885	0.000009	1	GO:0070062,extracellular exosome;GO:0031305,integral component of mitochondrial inner membrane;GO:0005739,mitochondrion		GO:0006915,apoptotic process;GO:0007007,inner mitochondrial membrane organization;GO:0090201,negative regulation of release of cytochrome c from mitochondria;GO:1905448,positive regulation of mitochondrial ATP synthesis coupled electron transport	
SSRA_HUMAN	P43307	SSR1	Translocon-associated protein subunit alpha	2.658993049	0.877121216	3.029467243	0.975578457	1.7680571325	2.00252285	1.7680571325	2.00252285	0.882914835403751	0.474927	0	1.13261207072447	0.474821	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane		GO:0006613,cotranslational protein targeting to membrane;GO:0036498,IRE1-mediated unfolded protein response;GO:0008284,positive regulation of cell population proliferation	hsa:6745,path:hsa04141,Protein processing in endoplasmic reticulum
MESD_HUMAN	Q14696	MESD	LRP chaperone MESD	1.257749424	2.271368444	0.085522325	0.058911134	1.764558934	0.0722167295	1.764558934	0.0722167295	24.4342127678324	0.002107	1	0.0409262213397969	0.002064	-1	GO:0005783,endoplasmic reticulum;GO:0005886,plasma membrane	GO:0042802,identical protein binding;GO:0050750,low-density lipoprotein particle receptor binding	GO:0007498,mesoderm development;GO:0001503,ossification;GO:0006909,phagocytosis;GO:1904395,positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0006457,protein folding;GO:0034394,protein localization to cell surface;GO:0016055,Wnt signaling pathway	
TTL12_HUMAN	Q14166	TTLL12	Tubulin--tyrosine ligase-like protein 12	1.39426568	0.740091748	2.213105895	1.920101406	1.067178714	2.0666036505	1.067178714	2.0666036505	0.516392542779939	0.240203	0	1.93651131098179	0.240526	0	GO:0005737,cytoplasm;GO:0005815,microtubule organizing center;GO:0030496,midbody;GO:0005634,nucleus;GO:0005819,spindle	GO:0005524,ATP binding;GO:1990889,H4K20me3 modified histone binding;GO:0015631,tubulin binding	GO:0034968,histone lysine methylation;GO:0045087,innate immune response;GO:0060339,negative regulation of type I interferon-mediated signaling pathway;GO:0018215,protein phosphopantetheinylation;GO:0007346,regulation of mitotic cell cycle;GO:0006464,cellular protein modification process	
ABHGA_HUMAN	O95870	ABHD16A	Phosphatidylserine lipase ABHD16A	0.169858413	0.167855795	0.239962778	0.179337938	0.168857104	0.209650358	0.168857104	0.209650358	0.805422445307725	0.489486	0	1.24158447014465	0.489589	0	GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0047372,acylglycerol lipase activity;GO:0008474,palmitoyl-(protein) hydrolase activity;GO:0004620,phospholipase activity;GO:0016787,hydrolase activity	GO:0052651,monoacylglycerol catabolic process;GO:0006660,phosphatidylserine catabolic process;GO:1905344,prostaglandin catabolic process	
MEMO1_HUMAN	Q9Y316	MEMO1	Protein MEMO1	0.246399737	0.240642951	0.265564871	2.55E-05	0.243521344	0.1327951855	0.243521344	0.1327951855	1.8338115428138	0.248582	0	0.545312305355871	0.248062	0	GO:0005829,cytosol;GO:0005634,nucleus;GO:0016021,integral component of membrane		GO:2000145,regulation of cell motility;GO:0032886,regulation of microtubule-based process	
AP1S1_HUMAN	P61966	AP1S1	AP-1 complex subunit sigma-1A	0.255899194	2.117429652	0.018980895	2.55E-05	1.186664423	0.0095031975	1.186664423	0.0095031975	124.870015907804	0.000011	1	0.00800832764158802	0.000011	-1	GO:0030121,AP-1 adaptor complex;GO:0005905,clathrin-coated pit;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0032588,trans-Golgi network membrane;GO:0030117,membrane coat		GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0006886,intracellular protein transport;GO:0006892,post-Golgi vesicle-mediated transport;GO:0006898,receptor-mediated endocytosis;GO:0050690,regulation of defense response to virus by virus;GO:0009615,response to virus;GO:0016192,vesicle-mediated transport	hsa:1174,path:hsa04142,Lysosome;hsa:1174,path:hsa05170,Human immunodeficiency virus 1 infection
TOIP1_HUMAN	Q5JTV8	TOR1AIP1	Torsin-1A-interacting protein 1	1.852750453	1.237598047	2.272364684	1.853150793	1.54517425	2.0627577385	1.54517425	2.0627577385	0.749081785592341	0.445443	0	1.33496771545345	0.445596	0	GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005637,nuclear inner membrane;GO:0031965,nuclear membrane;GO:0005634,nucleus	GO:0001671,ATPase activator activity;GO:0051117,ATPase binding;GO:0008092,cytoskeletal protein binding;GO:0005521,lamin binding	GO:0061024,membrane organization;GO:0071763,nuclear membrane organization;GO:0032781,positive regulation of ATPase activity;GO:0034504,protein localization to nucleus;GO:0090435,protein localization to nuclear envelope	
ADT1_HUMAN	P12235	SLC25A4	ADP/ATP translocase 1	0.961444819	1.130291367	1.496460842	1.899626551	1.045868093	1.6980436965	1.045868093	1.6980436965	0.615925311672331	0.331314	0	1.62357347725303	0.331578	0	GO:0032592,integral component of mitochondrial membrane;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005757,mitochondrial permeability transition pore complex;GO:0005739,mitochondrion;GO:0016021,integral component of membrane	GO:0015207,adenine transmembrane transporter activity;GO:0005471,ATP;GO:0017077,oxidative phosphorylation uncoupler activity;GO:0015078,proton transmembrane transporter activity	GO:1990845,adaptive thermogenesis;GO:0015866,ADP transport;GO:0008637,apoptotic mitochondrial changes;GO:0006091,generation of precursor metabolites and energy;GO:0140021,mitochondrial ADP transmembrane transport;GO:1990544,mitochondrial ATP transmembrane transport;GO:0000002,mitochondrial genome maintenance;GO:0060546,negative regulation of necroptotic process;GO:1901526,positive regulation of mitophagy;GO:0046902,regulation of mitochondrial membrane permeability;GO:0016032,viral process	hsa:291,path:hsa04020,Calcium signaling pathway;hsa:291,path:hsa04022,cGMP-PKG signaling pathway;hsa:291,path:hsa04217,Necroptosis;hsa:291,path:hsa04218,Cellular senescence;hsa:291,path:hsa05012,Parkinson disease;hsa:291,path:hsa05016,Huntington disease;hsa:291,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:291,path:hsa05164,Influenza A
RMND1_HUMAN	Q9NWS8	RMND1	Required for meiotic nuclear division protein 1 homolog	0.06124395	0.038235658	0.060762721	0.02761407	0.049739804	0.0441883955	0.049739804	0.0441883955	1.12563046105623	0.394505	0	0.888391025827122	0.394227	0	GO:0005739,mitochondrion		GO:0070131,positive regulation of mitochondrial translation;GO:0006412,translation	
RPIA_HUMAN	P49247	RPIA	Ribose-5-phosphate isomerase	0.147532187	0.032182923	0.277478791	0.389907263	0.089857555	0.333693027	0.089857555	0.333693027	0.269282087815398	0.044501	-1	3.71357786220647	0.044707	1	GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle	GO:0042802,identical protein binding;GO:0048029,monosaccharide binding;GO:0004751,ribose-5-phosphate isomerase activity	GO:0006014,D-ribose metabolic process;GO:0006098,pentose-phosphate shunt;GO:0009052,pentose-phosphate shunt, non-oxidative branch;GO:0019693,ribose phosphate metabolic process	hsa:22934,path:hsa00030,Pentose phosphate pathway
CEAM5_HUMAN	P06731	CEACAM5	Carcinoembryonic antigen-related cell adhesion molecule 5	11.16228009	0.329410721	4.330705706	1.248303509	5.7458454055	2.7895046075	5.7458454055	2.7895046075	2.05980853734797	0.218605	0	0.485482015375814	0.218057	0	GO:0031225,anchored component of membrane;GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0009986,cell surface;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0071575,integral component of external side of plasma membrane;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane	GO:0034235,GPI anchor binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity	GO:0006915,apoptotic process;GO:0007157,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034109,homotypic cell-cell adhesion;GO:0050900,leukocyte migration;GO:2000811,negative regulation of anoikis;GO:0043066,negative regulation of apoptotic process;GO:0010832,negative regulation of myotube differentiation	
APOL2_HUMAN	Q9BQE5	APOL2	Apolipoprotein L2	2.879214954	0.896822645	1.381785708	1.423351754	1.8880187995	1.402568731	1.8880187995	1.402568731	1.34611499441734	0.337840	0	0.742878583291352	0.337452	0	GO:0005789,endoplasmic reticulum membrane;GO:0005576,extracellular region;GO:0016020,membrane;GO:0016021,integral component of membrane	GO:0008035,high-density lipoprotein particle binding;GO:0008289,lipid binding;GO:0005102,signaling receptor binding	GO:0006953,acute-phase response;GO:0008203,cholesterol metabolic process;GO:0006629,lipid metabolic process;GO:0006869,lipid transport;GO:0042157,lipoprotein metabolic process;GO:0060135,maternal process involved in female pregnancy;GO:0007275,multicellular organism development	
GDS1_HUMAN	P52306	RAP1GDS1	Rap1 GTPase-GDP dissociation stimulator 1	1.355394031	1.541620297	1.770246866	1.136692472	1.448507164	1.453469669	1.448507164	1.453469669	0.996585752626393	0.434485	0	1.00342594439526	0.434291	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005739,mitochondrion	GO:0005096,GTPase activator activity	GO:0031034,myosin filament assembly;GO:0032471,negative regulation of endoplasmic reticulum calcium ion concentration;GO:0043547,positive regulation of GTPase activity;GO:0051561,positive regulation of mitochondrial calcium ion concentration;GO:0014829,vascular associated smooth muscle contraction	
COPG2_HUMAN	Q9UBF2	COPG2	Coatomer subunit gamma-2	6.962392275	0.716398103	0.951774905	6.856131093	3.839395189	3.903952999	3.839395189	3.903952999	0.983463476630857	0.438886	0	1.01681457803171	0.438701	0	GO:0030126,COPI vesicle coat;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0000139,Golgi membrane;GO:0030426,growth cone;GO:0030133,transport vesicle	GO:0005198,structural molecule activity	GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006891,intra-Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0072384,organelle transport along microtubule;GO:0009306,protein secretion;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	
MCU_HUMAN	Q8NE86	MCU	Calcium uniporter protein, mitochondrial	0.757307886	0.735401087	0.543760377	0.215683047	0.7463544865	0.379721712	0.7463544865	0.379721712	1.96553018411547	0.230432	0	0.508768579633908	0.229894	0	GO:0034704,calcium channel complex;GO:0031305,integral component of mitochondrial inner membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion;GO:1990246,uniplex complex;GO:0016021,integral component of membrane	GO:0005262,calcium channel activity;GO:0042802,identical protein binding;GO:0015292,uniporter activity	GO:0090527,actin filament reorganization;GO:0036444,calcium import into the mitochondrion;GO:0019722,calcium-mediated signaling;GO:0042593,glucose homeostasis;GO:0051560,mitochondrial calcium ion homeostasis;GO:0006851,mitochondrial calcium ion transmembrane transport;GO:0032024,positive regulation of insulin secretion;GO:0051561,positive regulation of mitochondrial calcium ion concentration;GO:0090141,positive regulation of mitochondrial fission;GO:0090023,positive regulation of neutrophil chemotaxis;GO:0051259,protein complex oligomerization	hsa:90550,path:hsa04020,Calcium signaling pathway;hsa:90550,path:hsa04218,Cellular senescence;hsa:90550,path:hsa04621,NOD-like receptor signaling pathway
ABCF3_HUMAN	Q9NUQ8	ABCF3	ATP-binding cassette sub-family F member 3	0.265317075	0.237662496	0.576076878	0.403752935	0.2514897855	0.4899149065	0.2514897855	0.4899149065	0.513333605822831	0.237388	0	1.94805091398036	0.237712	0	GO:0016020,membrane	GO:0005524,ATP binding;GO:0042626,ATPase-coupled transmembrane transporter activity;GO:0045296,cadherin binding	GO:0051607,defense response to virus	
CKAP5_HUMAN	Q14008	CKAP5	Cytoskeleton-associated protein 5	1.933763241	1.262876749	1.708136204	1.907346256	1.598319995	1.80774123	1.598319995	1.80774123	0.884153090318131	0.474457	0	1.13102584942635	0.474350	0	GO:0005813,centrosome;GO:0000777,condensed chromosome kinetochore;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0000776,kinetochore;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0000922,spindle pole	GO:0045296,cadherin binding;GO:0008017,microtubule binding;GO:0061863,microtubule plus end polymerase;GO:0043021,ribonucleoprotein complex binding	GO:0051301,cell division;GO:0007098,centrosome cycle;GO:0051298,centrosome duplication;GO:0097711,ciliary basal body-plasma membrane docking;GO:0030951,establishment or maintenance of microtubule cytoskeleton polarity;GO:0000086,G2/M transition of mitotic cell cycle;GO:0007019,microtubule depolymerization;GO:0046785,microtubule polymerization;GO:0007052,mitotic spindle organization;GO:0090063,positive regulation of microtubule nucleation;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0050658,RNA transport;GO:0007051,spindle organization	
RDH11_HUMAN	Q8TC12	RDH11	Retinol dehydrogenase 11	2.889375341	1.803028557	3.240658259	1.930510932	2.346201949	2.5855845955	2.346201949	2.5855845955	0.907416432277395	0.465749	0	1.10202985578544	0.465622	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane	GO:0102354,11-cis-retinol dehydrogenase activity;GO:0052650,NADP-retinol dehydrogenase activity;GO:0004745,retinol dehydrogenase activity;GO:0016491,oxidoreductase activity	GO:0110095,cellular detoxification of aldehyde;GO:0042574,retinal metabolic process;GO:0001523,retinoid metabolic process;GO:0042572,retinol metabolic process	hsa:51109,path:hsa00830,Retinol metabolism
RAB9A_HUMAN	P51151	RAB9A	Ras-related protein Rab-9A	0.27096624	3.679385336	0.089639448	0.003621029	1.975175788	0.0466302385	1.975175788	0.0466302385	42.3582604665425	0.000442	1	0.0236081460613773	0.000430	-1	GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0005770,late endosome;GO:0005764,lysosome;GO:0042470,melanosome;GO:0045335,phagocytic vesicle;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0032588,trans-Golgi network membrane;GO:0030133,transport vesicle	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0052405,negative regulation by host of symbiont molecular function;GO:0045921,positive regulation of exocytosis;GO:0015031,protein transport;GO:0032482,Rab protein signal transduction;GO:0032880,regulation of protein localization;GO:0042147,retrograde transport, endosome to Golgi	hsa:9367,path:hsa05132,Salmonella infection;hsa:9367,path:hsa05162,Measles
HACL2_HUMAN	A1L0T0	ILVBL	2-hydroxyacyl-CoA lyase 2	0.148785713	0.376754525	0.344849974	0.146277473	0.262770119	0.2455637235	0.262770119	0.2455637235	1.07006896317892	0.411017	0	0.93451920802304	0.410773	0	GO:0005948,acetolactate synthase complex;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0003984,acetolactate synthase activity;GO:0050660,flavin adenine dinucleotide binding;GO:0016829,lyase activity;GO:0000287,magnesium ion binding;GO:0030976,thiamine pyrophosphate binding;GO:0003824,catalytic activity	GO:0001561,fatty acid alpha-oxidation;GO:0009097,isoleucine biosynthetic process;GO:0009099,valine biosynthetic process;GO:0006631,fatty acid metabolic process	
DCTP1_HUMAN	Q9H773	DCTPP1	dCTP pyrophosphatase 1	0.531014075	0.463922096	0.019096454	2.55E-05	0.4974680855	0.009560977	0.4974680855	0.009560977	52.031093213591	0.000234	1	0.0192192771329046	0.000227	-1	GO:0005829,cytosol;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0047840,dCTP diphosphatase activity;GO:0042802,identical protein binding;GO:0000287,magnesium ion binding;GO:0047429,nucleoside-triphosphate diphosphatase activity;GO:0032556,pyrimidine deoxyribonucleotide binding	GO:0006253,dCTP catabolic process;GO:0042262,DNA protection;GO:0009143,nucleoside triphosphate catabolic process	hsa:79077,path:hsa00240,Pyrimidine metabolism
HLAH_HUMAN	P01893	HLA-H	Putative HLA class I histocompatibility antigen, alpha chain H	0.108975967	0.093260198	0.117277579	0.112396035	0.1011180825	0.114836807	0.1011180825	0.114836807	0.88053721747941	0.475832	0	1.13567033868547	0.475728	0	GO:0009986,cell surface;GO:0031901,early endosome membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0000139,Golgi membrane;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0042612,MHC class I protein complex;GO:0032398,MHC class Ib protein complex;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0030667,secretory granule membrane;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0030666,endocytic vesicle membrane;GO:0001772,immunological synapse;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0042613,MHC class II protein complex;GO:0032588,trans-Golgi network membrane;GO:0030658,transport vesicle membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0010008,endosome membrane;GO:0005882,intermediate filament;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0005797,Golgi medial cisterna;GO:0042824,MHC class I peptide loading complex;GO:0035577,azurophil granule membrane;GO:0033106,cis-Golgi network membrane;GO:0005769,early endosome;GO:0031527,filopodium membrane;GO:0005771,multivesicular body	GO:0030881,beta-2-microglobulin binding;GO:0042288,MHC class I protein binding;GO:0046703,natural killer cell lectin-like receptor binding;GO:0042605,peptide antigen binding;GO:0005102,signaling receptor binding;GO:0042608,T cell receptor binding;GO:0051087,chaperone binding;GO:0046977,TAP binding;GO:0023026,MHC class II protein complex binding;GO:0032395,MHC class II receptor activity;GO:0030247,polysaccharide binding;GO:0042609,CD4 receptor binding;GO:0005200,structural constituent of cytoskeleton;GO:0042610,CD8 receptor binding;GO:0003723,RNA binding;GO:0062061,TAP complex binding;GO:0071889,14-3-3 protein binding;GO:0046978,TAP1 binding;GO:0046979,TAP2 binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:1990405,protein antigen binding;GO:0015643,toxic substance binding;GO:0008134,transcription factor binding;GO:0031625,ubiquitin protein ligase binding;GO:0046872,metal ion binding	GO:0002250,adaptive immune response;GO:0019731,antibacterial humoral response;GO:0002476,antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0002477,antigen processing and presentation of exogenous peptide antigen via MHC class Ib;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0036037,CD8-positive, alpha-beta T cell activation;GO:0050830,defense response to Gram-positive bacterium;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0002519,natural killer cell tolerance induction;GO:0045953,negative regulation of natural killer cell mediated cytotoxicity;GO:0001815,positive regulation of antibody-dependent cellular cytotoxicity;GO:2001187,positive regulation of CD8-positive, alpha-beta T cell activation;GO:2000566,positive regulation of CD8-positive, alpha-beta T cell proliferation;GO:0002639,positive regulation of immunoglobulin production;GO:0032736,positive regulation of interleukin-13 production;GO:0032753,positive regulation of interleukin-4 production;GO:0002729,positive regulation of natural killer cell cytokine production;GO:0045954,positive regulation of natural killer cell mediated cytotoxicity;GO:0002717,positive regulation of natural killer cell mediated immunity;GO:0032819,positive regulation of natural killer cell proliferation;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:0032759,positive regulation of TRAIL production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0042270,protection from natural killer cell mediated cytotoxicity;GO:0050776,regulation of immune response;GO:0002715,regulation of natural killer cell mediated immunity;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process;GO:0002486,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006952,defense response;GO:0016045,detection of bacterium;GO:0006955,immune response;GO:0043312,neutrophil degranulation;GO:2001198,regulation of dendritic cell differentiation;GO:0032655,regulation of interleukin-12 production;GO:0032675,regulation of interleukin-6 production;GO:0002667,regulation of T cell anergy;GO:0002491,antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002504,antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0050890,cognition;GO:0002469,myeloid dendritic cell antigen processing and presentation;GO:0002503,peptide antigen assembly with MHC class II protein complex;GO:2000516,positive regulation of CD4-positive, alpha-beta T cell activation;GO:0032831,positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0043382,positive regulation of memory T cell differentiation;GO:0045622,regulation of T-helper cell differentiation;GO:0050852,T cell receptor signaling pathway;GO:0002399,MHC class II protein complex assembly;GO:2001190,positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0042102,positive regulation of T cell proliferation;GO:0032729,positive regulation of interferon-gamma production;GO:0050870,positive regulation of T cell activation;GO:0008544,epidermis development;GO:0006959,humoral immune response;GO:0002437,inflammatory response to antigenic stimulus;GO:0030225,macrophage differentiation;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0032689,negative regulation of interferon-gamma production;GO:0042130,negative regulation of T cell proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0033674,positive regulation of kinase activity;GO:0043410,positive regulation of MAPK cascade;GO:0045657,positive regulation of monocyte differentiation;GO:0001934,positive regulation of protein phosphorylation;GO:0002842,positive regulation of T cell mediated immune response to tumor cell;GO:0045893,positive regulation of transcription, DNA-templated;GO:0046598,positive regulation of viral entry into host cell;GO:0051262,protein tetramerization;GO:0032653,regulation of interleukin-10 production;GO:0032673,regulation of interleukin-4 production;GO:0007165,signal transduction;GO:0042088,T-helper 1 type immune response;GO:0002587,negative regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0045580,regulation of T cell differentiation;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002485,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent;GO:0042590,antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:2000568,positive regulation of memory T cell activation;GO:0002726,positive regulation of T cell cytokine production;GO:0016567,protein ubiquitination;GO:0001913,T cell mediated cytotoxicity;GO:0002419,T cell mediated cytotoxicity directed against tumor cell target;GO:0002728,negative regulation of natural killer cell cytokine production;GO:0043322,negative regulation of natural killer cell degranulation;GO:1901215,negative regulation of neuron death;GO:0002725,negative regulation of T cell cytokine production;GO:0043323,positive regulation of natural killer cell degranulation;GO:0071346,cellular response to interferon-gamma;GO:0006968,cellular defense response;GO:0002767,immune response-inhibiting cell surface receptor signaling pathway;GO:0016525,negative regulation of angiogenesis;GO:2001199,negative regulation of dendritic cell differentiation;GO:0070317,negative regulation of G0 to G1 transition;GO:0050777,negative regulation of immune response;GO:0051898,negative regulation of protein kinase B signaling;GO:0001915,negative regulation of T cell mediated cytotoxicity;GO:0002451,peripheral B cell tolerance induction;GO:2000774,positive regulation of cellular senescence;GO:2000353,positive regulation of endothelial cell apoptotic process;GO:0032735,positive regulation of interleukin-12 production;GO:0060907,positive regulation of macrophage cytokine production;GO:0045591,positive regulation of regulatory T cell differentiation;GO:0002666,positive regulation of T cell tolerance induction;GO:0002645,positive regulation of tolerance induction;GO:0070207,protein homotrimerization;GO:0019882,antigen processing and presentation;GO:0002344,B cell affinity maturation;GO:0046635,positive regulation of alpha-beta T cell activation;GO:0002579,positive regulation of antigen processing and presentation;GO:0002827,positive regulation of T-helper 1 type immune response	hsa:3133,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3133,path:hsa04144,Endocytosis;hsa:3133,path:hsa04145,Phagosome;hsa:3133,path:hsa04218,Cellular senescence;hsa:3133,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3133,path:hsa04612,Antigen processing and presentation;hsa:3133,path:hsa05203,Viral carcinogenesis;hsa:3133,path:hsa05320,Autoimmune thyroid disease;hsa:3133,path:hsa05330,Allograft rejection;hsa:3133,path:hsa05332,Graft-versus-host disease;hsa:3133,path:hsa05416,Viral myocarditis;hsa:3133,path:hsa04940,Type I diabetes mellitus;hsa:3133,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3133,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3133,path:hsa05168,Herpes simplex virus 1 infection;hsa:3133,path:hsa05163,Human cytomegalovirus infection;hsa:3133,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3133,path:hsa05169,Epstein-Barr virus infection;hsa:3133,path:hsa05165,Human papillomavirus infection;hsa:3106,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3106,path:hsa04144,Endocytosis;hsa:3106,path:hsa04145,Phagosome;hsa:3106,path:hsa04218,Cellular senescence;hsa:3106,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3106,path:hsa04612,Antigen processing and presentation;hsa:3106,path:hsa05203,Viral carcinogenesis;hsa:3106,path:hsa05320,Autoimmune thyroid disease;hsa:3106,path:hsa05330,Allograft rejection;hsa:3106,path:hsa05332,Graft-versus-host disease;hsa:3106,path:hsa05416,Viral myocarditis;hsa:3106,path:hsa04940,Type I diabetes mellitus;hsa:3106,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3106,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3106,path:hsa05168,Herpes simplex virus 1 infection;hsa:3106,path:hsa05163,Human cytomegalovirus infection;hsa:3106,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3106,path:hsa05169,Epstein-Barr virus infection;hsa:3106,path:hsa05165,Human papillomavirus infection;hsa:3122,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3122,path:hsa04145,Phagosome;hsa:3122,path:hsa04640,Hematopoietic cell lineage;hsa:3122,path:hsa04612,Antigen processing and presentation;hsa:3122,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3122,path:hsa04659,Th17 cell differentiation;hsa:3122,path:hsa04672,Intestinal immune network for IgA production;hsa:3122,path:hsa05310,Asthma;hsa:3122,path:hsa05322,Systemic lupus erythematosus;hsa:3122,path:hsa05323,Rheumatoid arthritis;hsa:3122,path:hsa05320,Autoimmune thyroid disease;hsa:3122,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3122,path:hsa05330,Allograft rejection;hsa:3122,path:hsa05332,Graft-versus-host disease;hsa:3122,path:hsa05416,Viral myocarditis;hsa:3122,path:hsa04940,Type I diabetes mellitus;hsa:3122,path:hsa05150,Staphylococcus aureus infection;hsa:3122,path:hsa05152,Tuberculosis;hsa:3122,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3122,path:hsa05164,Influenza A;hsa:3122,path:hsa05168,Herpes simplex virus 1 infection;hsa:3122,path:hsa05169,Epstein-Barr virus infection;hsa:3122,path:hsa05145,Toxoplasmosis;hsa:3122,path:hsa05140,Leishmaniasis;hsa:3109,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3109,path:hsa04145,Phagosome;hsa:3109,path:hsa04640,Hematopoietic cell lineage;hsa:3109,path:hsa04612,Antigen processing and presentation;hsa:3109,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3109,path:hsa04659,Th17 cell differentiation;hsa:3109,path:hsa04672,Intestinal immune network for IgA production;hsa:3109,path:hsa05310,Asthma;hsa:3109,path:hsa05322,Systemic lupus erythematosus;hsa:3109,path:hsa05323,Rheumatoid arthritis;hsa:3109,path:hsa05320,Autoimmune thyroid disease;hsa:3109,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3109,path:hsa05330,Allograft rejection;hsa:3109,path:hsa05332,Graft-versus-host disease;hsa:3109,path:hsa05416,Viral myocarditis;hsa:3109,path:hsa04940,Type I diabetes mellitus;hsa:3109,path:hsa05150,Staphylococcus aureus infection;hsa:3109,path:hsa05152,Tuberculosis;hsa:3109,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3109,path:hsa05164,Influenza A;hsa:3109,path:hsa05168,Herpes simplex virus 1 infection;hsa:3109,path:hsa05169,Epstein-Barr virus infection;hsa:3109,path:hsa05145,Toxoplasmosis;hsa:3109,path:hsa05140,Leishmaniasis;hsa:3115,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3115,path:hsa04145,Phagosome;hsa:3115,path:hsa04640,Hematopoietic cell lineage;hsa:3115,path:hsa04612,Antigen processing and presentation;hsa:3115,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3115,path:hsa04659,Th17 cell differentiation;hsa:3115,path:hsa04672,Intestinal immune network for IgA production;hsa:3115,path:hsa05310,Asthma;hsa:3115,path:hsa05322,Systemic lupus erythematosus;hsa:3115,path:hsa05323,Rheumatoid arthritis;hsa:3115,path:hsa05320,Autoimmune thyroid disease;hsa:3115,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3115,path:hsa05330,Allograft rejection;hsa:3115,path:hsa05332,Graft-versus-host disease;hsa:3115,path:hsa05416,Viral myocarditis;hsa:3115,path:hsa04940,Type I diabetes mellitus;hsa:3115,path:hsa05150,Staphylococcus aureus infection;hsa:3115,path:hsa05152,Tuberculosis;hsa:3115,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3115,path:hsa05164,Influenza A;hsa:3115,path:hsa05168,Herpes simplex virus 1 infection;hsa:3115,path:hsa05169,Epstein-Barr virus infection;hsa:3115,path:hsa05145,Toxoplasmosis;hsa:3115,path:hsa05140,Leishmaniasis;hsa:3123,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3123,path:hsa04145,Phagosome;hsa:3123,path:hsa04640,Hematopoietic cell lineage;hsa:3123,path:hsa04612,Antigen processing and presentation;hsa:3123,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3123,path:hsa04659,Th17 cell differentiation;hsa:3123,path:hsa04672,Intestinal immune network for IgA production;hsa:3123,path:hsa05310,Asthma;hsa:3123,path:hsa05322,Systemic lupus erythematosus;hsa:3123,path:hsa05323,Rheumatoid arthritis;hsa:3123,path:hsa05320,Autoimmune thyroid disease;hsa:3123,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3123,path:hsa05330,Allograft rejection;hsa:3123,path:hsa05332,Graft-versus-host disease;hsa:3123,path:hsa05416,Viral myocarditis;hsa:3123,path:hsa04940,Type I diabetes mellitus;hsa:3123,path:hsa05150,Staphylococcus aureus infection;hsa:3123,path:hsa05152,Tuberculosis;hsa:3123,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3123,path:hsa05164,Influenza A;hsa:3123,path:hsa05168,Herpes simplex virus 1 infection;hsa:3123,path:hsa05169,Epstein-Barr virus infection;hsa:3123,path:hsa05145,Toxoplasmosis;hsa:3123,path:hsa05140,Leishmaniasis;hsa:3111,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3111,path:hsa04145,Phagosome;hsa:3111,path:hsa04640,Hematopoietic cell lineage;hsa:3111,path:hsa04612,Antigen processing and presentation;hsa:3111,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3111,path:hsa04659,Th17 cell differentiation;hsa:3111,path:hsa04672,Intestinal immune network for IgA production;hsa:3111,path:hsa05310,Asthma;hsa:3111,path:hsa05322,Systemic lupus erythematosus;hsa:3111,path:hsa05323,Rheumatoid arthritis;hsa:3111,path:hsa05320,Autoimmune thyroid disease;hsa:3111,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3111,path:hsa05330,Allograft rejection;hsa:3111,path:hsa05332,Graft-versus-host disease;hsa:3111,path:hsa05416,Viral myocarditis;hsa:3111,path:hsa04940,Type I diabetes mellitus;hsa:3111,path:hsa05150,Staphylococcus aureus infection;hsa:3111,path:hsa05152,Tuberculosis;hsa:3111,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3111,path:hsa05164,Influenza A;hsa:3111,path:hsa05168,Herpes simplex virus 1 infection;hsa:3111,path:hsa05169,Epstein-Barr virus infection;hsa:3111,path:hsa05145,Toxoplasmosis;hsa:3111,path:hsa05140,Leishmaniasis;hsa:3112,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3112,path:hsa04145,Phagosome;hsa:3112,path:hsa04640,Hematopoietic cell lineage;hsa:3112,path:hsa04612,Antigen processing and presentation;hsa:3112,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3112,path:hsa04659,Th17 cell differentiation;hsa:3112,path:hsa04672,Intestinal immune network for IgA production;hsa:3112,path:hsa05310,Asthma;hsa:3112,path:hsa05322,Systemic lupus erythematosus;hsa:3112,path:hsa05323,Rheumatoid arthritis;hsa:3112,path:hsa05320,Autoimmune thyroid disease;hsa:3112,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3112,path:hsa05330,Allograft rejection;hsa:3112,path:hsa05332,Graft-versus-host disease;hsa:3112,path:hsa05416,Viral myocarditis;hsa:3112,path:hsa04940,Type I diabetes mellitus;hsa:3112,path:hsa05150,Staphylococcus aureus infection;hsa:3112,path:hsa05152,Tuberculosis;hsa:3112,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3112,path:hsa05164,Influenza A;hsa:3112,path:hsa05168,Herpes simplex virus 1 infection;hsa:3112,path:hsa05169,Epstein-Barr virus infection;hsa:3112,path:hsa05145,Toxoplasmosis;hsa:3112,path:hsa05140,Leishmaniasis;hsa:3105,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3105,path:hsa04144,Endocytosis;hsa:3105,path:hsa04145,Phagosome;hsa:3105,path:hsa04218,Cellular senescence;hsa:3105,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3105,path:hsa04612,Antigen processing and presentation;hsa:3105,path:hsa05203,Viral carcinogenesis;hsa:3105,path:hsa05320,Autoimmune thyroid disease;hsa:3105,path:hsa05330,Allograft rejection;hsa:3105,path:hsa05332,Graft-versus-host disease;hsa:3105,path:hsa05416,Viral myocarditis;hsa:3105,path:hsa04940,Type I diabetes mellitus;hsa:3105,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3105,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3105,path:hsa05168,Herpes simplex virus 1 infection;hsa:3105,path:hsa05163,Human cytomegalovirus infection;hsa:3105,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3105,path:hsa05169,Epstein-Barr virus infection;hsa:3105,path:hsa05165,Human papillomavirus infection;hsa:3134,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3134,path:hsa04144,Endocytosis;hsa:3134,path:hsa04145,Phagosome;hsa:3134,path:hsa04218,Cellular senescence;hsa:3134,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3134,path:hsa04612,Antigen processing and presentation;hsa:3134,path:hsa05203,Viral carcinogenesis;hsa:3134,path:hsa05320,Autoimmune thyroid disease;hsa:3134,path:hsa05330,Allograft rejection;hsa:3134,path:hsa05332,Graft-versus-host disease;hsa:3134,path:hsa05416,Viral myocarditis;hsa:3134,path:hsa04940,Type I diabetes mellitus;hsa:3134,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3134,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3134,path:hsa05168,Herpes simplex virus 1 infection;hsa:3134,path:hsa05163,Human cytomegalovirus infection;hsa:3134,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3134,path:hsa05169,Epstein-Barr virus infection;hsa:3134,path:hsa05165,Human papillomavirus infection;hsa:3119,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3119,path:hsa04145,Phagosome;hsa:3119,path:hsa04640,Hematopoietic cell lineage;hsa:3119,path:hsa04612,Antigen processing and presentation;hsa:3119,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3119,path:hsa04659,Th17 cell differentiation;hsa:3119,path:hsa04672,Intestinal immune network for IgA production;hsa:3119,path:hsa05310,Asthma;hsa:3119,path:hsa05322,Systemic lupus erythematosus;hsa:3119,path:hsa05323,Rheumatoid arthritis;hsa:3119,path:hsa05320,Autoimmune thyroid disease;hsa:3119,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3119,path:hsa05330,Allograft rejection;hsa:3119,path:hsa05332,Graft-versus-host disease;hsa:3119,path:hsa05416,Viral myocarditis;hsa:3119,path:hsa04940,Type I diabetes mellitus;hsa:3119,path:hsa05150,Staphylococcus aureus infection;hsa:3119,path:hsa05152,Tuberculosis;hsa:3119,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3119,path:hsa05164,Influenza A;hsa:3119,path:hsa05168,Herpes simplex virus 1 infection;hsa:3119,path:hsa05169,Epstein-Barr virus infection;hsa:3119,path:hsa05145,Toxoplasmosis;hsa:3119,path:hsa05140,Leishmaniasis;hsa:3113,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3113,path:hsa04145,Phagosome;hsa:3113,path:hsa04640,Hematopoietic cell lineage;hsa:3113,path:hsa04612,Antigen processing and presentation;hsa:3113,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3113,path:hsa04659,Th17 cell differentiation;hsa:3113,path:hsa04672,Intestinal immune network for IgA production;hsa:3113,path:hsa05310,Asthma;hsa:3113,path:hsa05322,Systemic lupus erythematosus;hsa:3113,path:hsa05323,Rheumatoid arthritis;hsa:3113,path:hsa05320,Autoimmune thyroid disease;hsa:3113,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3113,path:hsa05330,Allograft rejection;hsa:3113,path:hsa05332,Graft-versus-host disease;hsa:3113,path:hsa05416,Viral myocarditis;hsa:3113,path:hsa04940,Type I diabetes mellitus;hsa:3113,path:hsa05150,Staphylococcus aureus infection;hsa:3113,path:hsa05152,Tuberculosis;hsa:3113,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3113,path:hsa05164,Influenza A;hsa:3113,path:hsa05168,Herpes simplex virus 1 infection;hsa:3113,path:hsa05169,Epstein-Barr virus infection;hsa:3113,path:hsa05145,Toxoplasmosis;hsa:3113,path:hsa05140,Leishmaniasis;hsa:3125,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3125,path:hsa04145,Phagosome;hsa:3125,path:hsa04640,Hematopoietic cell lineage;hsa:3125,path:hsa04612,Antigen processing and presentation;hsa:3125,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3125,path:hsa04659,Th17 cell differentiation;hsa:3125,path:hsa04672,Intestinal immune network for IgA production;hsa:3125,path:hsa05310,Asthma;hsa:3125,path:hsa05322,Systemic lupus erythematosus;hsa:3125,path:hsa05323,Rheumatoid arthritis;hsa:3125,path:hsa05320,Autoimmune thyroid disease;hsa:3125,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3125,path:hsa05330,Allograft rejection;hsa:3125,path:hsa05332,Graft-versus-host disease;hsa:3125,path:hsa05416,Viral myocarditis;hsa:3125,path:hsa04940,Type I diabetes mellitus;hsa:3125,path:hsa05150,Staphylococcus aureus infection;hsa:3125,path:hsa05152,Tuberculosis;hsa:3125,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3125,path:hsa05164,Influenza A;hsa:3125,path:hsa05168,Herpes simplex virus 1 infection;hsa:3125,path:hsa05169,Epstein-Barr virus infection;hsa:3125,path:hsa05145,Toxoplasmosis;hsa:3125,path:hsa05140,Leishmaniasis;hsa:3126,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3126,path:hsa04145,Phagosome;hsa:3126,path:hsa04640,Hematopoietic cell lineage;hsa:3126,path:hsa04612,Antigen processing and presentation;hsa:3126,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3126,path:hsa04659,Th17 cell differentiation;hsa:3126,path:hsa04672,Intestinal immune network for IgA production;hsa:3126,path:hsa05310,Asthma;hsa:3126,path:hsa05322,Systemic lupus erythematosus;hsa:3126,path:hsa05323,Rheumatoid arthritis;hsa:3126,path:hsa05320,Autoimmune thyroid disease;hsa:3126,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3126,path:hsa05330,Allograft rejection;hsa:3126,path:hsa05332,Graft-versus-host disease;hsa:3126,path:hsa05416,Viral myocarditis;hsa:3126,path:hsa04940,Type I diabetes mellitus;hsa:3126,path:hsa05150,Staphylococcus aureus infection;hsa:3126,path:hsa05152,Tuberculosis;hsa:3126,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3126,path:hsa05164,Influenza A;hsa:3126,path:hsa05168,Herpes simplex virus 1 infection;hsa:3126,path:hsa05169,Epstein-Barr virus infection;hsa:3126,path:hsa05145,Toxoplasmosis;hsa:3126,path:hsa05140,Leishmaniasis;hsa:3107,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3107,path:hsa04144,Endocytosis;hsa:3107,path:hsa04145,Phagosome;hsa:3107,path:hsa04218,Cellular senescence;hsa:3107,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3107,path:hsa04612,Antigen processing and presentation;hsa:3107,path:hsa05203,Viral carcinogenesis;hsa:3107,path:hsa05320,Autoimmune thyroid disease;hsa:3107,path:hsa05330,Allograft rejection;hsa:3107,path:hsa05332,Graft-versus-host disease;hsa:3107,path:hsa05416,Viral myocarditis;hsa:3107,path:hsa04940,Type I diabetes mellitus;hsa:3107,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3107,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3107,path:hsa05168,Herpes simplex virus 1 infection;hsa:3107,path:hsa05163,Human cytomegalovirus infection;hsa:3107,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3107,path:hsa05169,Epstein-Barr virus infection;hsa:3107,path:hsa05165,Human papillomavirus infection;hsa:3135,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3135,path:hsa04144,Endocytosis;hsa:3135,path:hsa04145,Phagosome;hsa:3135,path:hsa04218,Cellular senescence;hsa:3135,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3135,path:hsa04612,Antigen processing and presentation;hsa:3135,path:hsa05203,Viral carcinogenesis;hsa:3135,path:hsa05320,Autoimmune thyroid disease;hsa:3135,path:hsa05330,Allograft rejection;hsa:3135,path:hsa05332,Graft-versus-host disease;hsa:3135,path:hsa05416,Viral myocarditis;hsa:3135,path:hsa04940,Type I diabetes mellitus;hsa:3135,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3135,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3135,path:hsa05168,Herpes simplex virus 1 infection;hsa:3135,path:hsa05163,Human cytomegalovirus infection;hsa:3135,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3135,path:hsa05169,Epstein-Barr virus infection;hsa:3135,path:hsa05165,Human papillomavirus infection;hsa:3127,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3127,path:hsa04145,Phagosome;hsa:3127,path:hsa04640,Hematopoietic cell lineage;hsa:3127,path:hsa04612,Antigen processing and presentation;hsa:3127,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3127,path:hsa04659,Th17 cell differentiation;hsa:3127,path:hsa04672,Intestinal immune network for IgA production;hsa:3127,path:hsa05310,Asthma;hsa:3127,path:hsa05322,Systemic lupus erythematosus;hsa:3127,path:hsa05323,Rheumatoid arthritis;hsa:3127,path:hsa05320,Autoimmune thyroid disease;hsa:3127,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3127,path:hsa05330,Allograft rejection;hsa:3127,path:hsa05332,Graft-versus-host disease;hsa:3127,path:hsa05416,Viral myocarditis;hsa:3127,path:hsa04940,Type I diabetes mellitus;hsa:3127,path:hsa05150,Staphylococcus aureus infection;hsa:3127,path:hsa05152,Tuberculosis;hsa:3127,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3127,path:hsa05164,Influenza A;hsa:3127,path:hsa05168,Herpes simplex virus 1 infection;hsa:3127,path:hsa05169,Epstein-Barr virus infection;hsa:3127,path:hsa05145,Toxoplasmosis;hsa:3127,path:hsa05140,Leishmaniasis;hsa:3118,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3118,path:hsa04145,Phagosome;hsa:3118,path:hsa04640,Hematopoietic cell lineage;hsa:3118,path:hsa04612,Antigen processing and presentation;hsa:3118,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3118,path:hsa04659,Th17 cell differentiation;hsa:3118,path:hsa04672,Intestinal immune network for IgA production;hsa:3118,path:hsa05310,Asthma;hsa:3118,path:hsa05322,Systemic lupus erythematosus;hsa:3118,path:hsa05323,Rheumatoid arthritis;hsa:3118,path:hsa05320,Autoimmune thyroid disease;hsa:3118,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3118,path:hsa05330,Allograft rejection;hsa:3118,path:hsa05332,Graft-versus-host disease;hsa:3118,path:hsa05416,Viral myocarditis;hsa:3118,path:hsa04940,Type I diabetes mellitus;hsa:3118,path:hsa05150,Staphylococcus aureus infection;hsa:3118,path:hsa05152,Tuberculosis;hsa:3118,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3118,path:hsa05164,Influenza A;hsa:3118,path:hsa05168,Herpes simplex virus 1 infection;hsa:3118,path:hsa05169,Epstein-Barr virus infection;hsa:3118,path:hsa05145,Toxoplasmosis;hsa:3118,path:hsa05140,Leishmaniasis;hsa:3117,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3117,path:hsa04145,Phagosome;hsa:3117,path:hsa04640,Hematopoietic cell lineage;hsa:3117,path:hsa04612,Antigen processing and presentation;hsa:3117,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3117,path:hsa04659,Th17 cell differentiation;hsa:3117,path:hsa04672,Intestinal immune network for IgA production;hsa:3117,path:hsa05310,Asthma;hsa:3117,path:hsa05322,Systemic lupus erythematosus;hsa:3117,path:hsa05323,Rheumatoid arthritis;hsa:3117,path:hsa05320,Autoimmune thyroid disease;hsa:3117,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3117,path:hsa05330,Allograft rejection;hsa:3117,path:hsa05332,Graft-versus-host disease;hsa:3117,path:hsa05416,Viral myocarditis;hsa:3117,path:hsa04940,Type I diabetes mellitus;hsa:3117,path:hsa05150,Staphylococcus aureus infection;hsa:3117,path:hsa05152,Tuberculosis;hsa:3117,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3117,path:hsa05164,Influenza A;hsa:3117,path:hsa05168,Herpes simplex virus 1 infection;hsa:3117,path:hsa05169,Epstein-Barr virus infection;hsa:3117,path:hsa05145,Toxoplasmosis;hsa:3117,path:hsa05140,Leishmaniasis
SSRP1_HUMAN	Q08945	SSRP1	FACT complex subunit SSRP1	4.20301437	1.383498463	3.706319323	4.596065458	2.7932564165	4.1511923905	2.7932564165	4.1511923905	0.672880501248837	0.381658	0	1.48614798339979	0.381876	0	GO:0035101,FACT complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005694,chromosome;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0042393,histone binding;GO:0031491,nucleosome binding;GO:0003723,RNA binding	GO:0006281,DNA repair;GO:0006260,DNA replication;GO:1902275,regulation of chromatin organization;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter;GO:0016032,viral process	
MYDGF_HUMAN	Q969H8	MYDGF	Myeloid-derived growth factor	5.754914583	18.28362417	0.719718105	0.396844308	12.0192693765	0.5582812065	12.0192693765	0.5582812065	21.5290596146908	0.002935	1	0.046448847181306	0.002879	-1	GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0005615,extracellular space;GO:0005794,Golgi apparatus		GO:0001525,angiogenesis;GO:0006915,apoptotic process;GO:0036498,IRE1-mediated unfolded protein response;GO:0043066,negative regulation of apoptotic process;GO:0045766,positive regulation of angiogenesis;GO:0001938,positive regulation of endothelial cell proliferation;GO:0043410,positive regulation of MAPK cascade;GO:0014068,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0051897,positive regulation of protein kinase B signaling;GO:0001934,positive regulation of protein phosphorylation;GO:0045944,positive regulation of transcription by RNA polymerase II	
COMD9_HUMAN	Q9P000	COMMD9	COMM domain-containing protein 9	2.55E-05	0.298903363	0.01465599	0.013042874	0.1494644315	0.013849432	0.1494644315	0.013849432	10.7920982968832	0.014895	1	0.0926603865616015	0.014709	-1	GO:0005829,cytosol;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005794,Golgi apparatus;GO:0005654,nucleoplasm;GO:0034774,secretory granule lumen		GO:0042632,cholesterol homeostasis;GO:0043312,neutrophil degranulation;GO:0006814,sodium ion transport	
S22AI_HUMAN	Q96BI1	SLC22A18	Solute carrier family 22 member 18	1.337291806	1.88026613	0.847038149	1.413283185	1.608778968	1.130160667	1.608778968	1.130160667	1.42349580460138	0.320795	0	0.702495923604093	0.320378	0	GO:0016324,apical plasma membrane;GO:0005737,cytoplasm;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0005886,plasma membrane	GO:0015293,symporter activity;GO:0022857,transmembrane transporter activity;GO:0031625,ubiquitin protein ligase binding	GO:0007588,excretion;GO:0015695,organic cation transport;GO:1990961,xenobiotic detoxification by transmembrane export across the plasma membrane;GO:0042908,xenobiotic transport	
P63_HUMAN	Q9H3D4	TP63	Tumor protein 63	2.55E-05	0.266123872	2.55E-05	0.211373023	0.133074686	0.1056992615	0.133074686	0.1056992615	1.25899352664824	0.358687	0	0.794285259482033	0.358338	0	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0030425,dendrite;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0005791,rough endoplasmic reticulum	GO:0003682,chromatin binding;GO:0003684,damaged DNA binding;GO:0003677,DNA binding;GO:0001228,DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700,DNA-binding transcription factor activity;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0042802,identical protein binding;GO:0097371,MDM2/MDM4 family protein binding;GO:0046872,metal ion binding;GO:0002039,p53 binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000977,RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0050699,WW domain binding	GO:0006915,apoptotic process;GO:0007569,cell aging;GO:0008283,cell population proliferation;GO:0006974,cellular response to DNA damage stimulus;GO:0006338,chromatin remodeling;GO:0060197,cloacal septation;GO:1904888,cranial skeletal system development;GO:0007499,ectoderm and mesoderm interaction;GO:0035115,embryonic forelimb morphogenesis;GO:0035116,embryonic hindlimb morphogenesis;GO:0010481,epidermal cell division;GO:0002064,epithelial cell development;GO:0001736,establishment of planar polarity;GO:0061436,establishment of skin barrier;GO:0048807,female genitalia morphogenesis;GO:0031069,hair follicle morphogenesis;GO:0042771,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0030216,keratinocyte differentiation;GO:0010259,multicellular organism aging;GO:2000773,negative regulation of cellular senescence;GO:0033147,negative regulation of intracellular estrogen receptor signaling pathway;GO:0045617,negative regulation of keratinocyte differentiation;GO:2000381,negative regulation of mesoderm development;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0051402,neuron apoptotic process;GO:0007219,Notch signaling pathway;GO:0042475,odontogenesis of dentin-containing tooth;GO:0030859,polarized epithelial cell differentiation;GO:2001235,positive regulation of apoptotic signaling pathway;GO:1902808,positive regulation of cell cycle G1/S phase transition;GO:2000271,positive regulation of fibroblast apoptotic process;GO:0010838,positive regulation of keratinocyte proliferation;GO:0045747,positive regulation of Notch signaling pathway;GO:0045669,positive regulation of osteoblast differentiation;GO:1900740,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:1904674,positive regulation of somatic stem cell population maintenance;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0036342,post-anal tail morphogenesis;GO:0060513,prostatic bud formation;GO:0051262,protein tetramerization;GO:0009954,proximal/distal pattern formation;GO:0042981,regulation of apoptotic process;GO:0043281,regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0010482,regulation of epidermal cell division;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0006357,regulation of transcription by RNA polymerase II;GO:0001501,skeletal system development;GO:0043589,skin morphogenesis;GO:0007283,spermatogenesis;GO:0060529,squamous basal epithelial stem cell differentiation involved in prostate gland acinus development;GO:0048485,sympathetic nervous system development;GO:0032502,developmental process	hsa:8626,path:hsa05206,MicroRNAs in cancer
PPM1G_HUMAN	O15355	PPM1G	Protein phosphatase 1G	0.34522689	0.920471915	0.149544857	0.610571664	0.6328494025	0.3800582605	0.6328494025	0.3800582605	1.66513787035554	0.275043	0	0.600550871974632	0.274556	0	GO:0005737,cytoplasm;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0046872,metal ion binding;GO:0106306,protein serine phosphatase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0106307,protein threonine phosphatase activity	GO:0007050,cell cycle arrest;GO:0035970,peptidyl-threonine dephosphorylation;GO:0006470,protein dephosphorylation	
SEPT6_HUMAN	Q14141	SEPTIN6	Septin-6	0.63697824	0.143359002	0.996565255	0.483612978	0.390168621	0.7400891165	0.390168621	0.7400891165	0.527191404793479	0.250149	0	1.89684427877146	0.250468	0	GO:0043679,axon terminus;GO:0032153,cell division site;GO:0032154,cleavage furrow;GO:0000777,condensed chromosome kinetochore;GO:0015630,microtubule cytoskeleton;GO:0030496,midbody;GO:0032173,septin collar;GO:0031105,septin complex;GO:0005940,septin ring;GO:0097227,sperm annulus;GO:0005819,spindle;GO:0008021,synaptic vesicle	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0060090,molecular adaptor activity	GO:0030154,cell differentiation;GO:0034613,cellular protein localization;GO:0060271,cilium assembly;GO:0061640,cytoskeleton-dependent cytokinesis;GO:0000281,mitotic cytokinesis;GO:0007283,spermatogenesis;GO:0016032,viral process	hsa:23157,path:hsa05131,Shigellosis;hsa:23157,path:hsa05100,Bacterial invasion of epithelial cells
MAIP1_HUMAN	Q8WWC4	MAIP1	m-AAA protease-interacting protein 1, mitochondrial	0.579078398	0.476060243	0.135866509	0.04208152	0.5275693205	0.0889740145	0.5275693205	0.0889740145	5.92947641471207	0.047649	1	0.168648954824885	0.047268	-1	GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix	GO:0043022,ribosome binding	GO:0036444,calcium import into the mitochondrion;GO:0007007,inner mitochondrial membrane organization;GO:0051560,mitochondrial calcium ion homeostasis;GO:0006851,mitochondrial calcium ion transmembrane transport;GO:0032979,protein insertion into mitochondrial inner membrane from matrix;GO:0051204,protein insertion into mitochondrial membrane	
HDHD2_HUMAN	Q9H0R4	HDHD2	Haloacid dehalogenase-like hydrolase domain-containing protein 2	0.239286029	0.185704762	0.361700959	0.061459112	0.2124953955	0.2115800355	0.2124953955	0.2115800355	1.0043263061084	0.431920	0	0.995692330189809	0.431720	0	GO:0070062,extracellular exosome	GO:0019899,enzyme binding;GO:0046872,metal ion binding;GO:0016791,phosphatase activity	GO:0016311,dephosphorylation	
SNX9_HUMAN	Q9Y5X1	SNX9	Sorting nexin-9	0.841012846	0.7442454	1.023618322	1.040638325	0.792629123	1.0321283235	0.792629123	1.0321283235	0.767955984690115	0.460508	0	1.30215796209143	0.460644	0	GO:0030136,clathrin-coated vesicle;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0005886,plasma membrane;GO:0001726,ruffle;GO:0005802,trans-Golgi network	GO:0005545,1-phosphatidylinositol binding;GO:0071933,Arp2/3 complex binding;GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0035091,phosphatidylinositol binding;GO:0042803,protein homodimerization activity;GO:0031625,ubiquitin protein ligase binding	GO:0036089,cleavage furrow formation;GO:0006897,endocytosis;GO:0016197,endosomal transport;GO:0006886,intracellular protein transport;GO:0060988,lipid tube assembly;GO:0061024,membrane organization;GO:0000281,mitotic cytokinesis;GO:0097320,plasma membrane tubulation;GO:0030838,positive regulation of actin filament polymerization;GO:0043547,positive regulation of GTPase activity;GO:0051044,positive regulation of membrane protein ectodomain proteolysis;GO:0045860,positive regulation of protein kinase activity;GO:0065003,protein-containing complex assembly;GO:0006898,receptor-mediated endocytosis	hsa:51429,path:hsa05132,Salmonella infection
TPM4_HUMAN	P67936	TPM4	Tropomyosin alpha-4 chain	22.12121349	16.68506058	11.38666407	16.57467236	19.403137035	13.980668215	19.403137035	13.980668215	1.38785476749832	0.328483	0	0.720536487980331	0.328080	0	GO:0005884,actin filament;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005862,muscle thin filament tropomyosin;GO:0001725,stress fiber	GO:0051015,actin filament binding;GO:0005509,calcium ion binding;GO:0042802,identical protein binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0008307,structural constituent of muscle;GO:0003779,actin binding	GO:0007015,actin filament organization;GO:0006936,muscle contraction;GO:0030049,muscle filament sliding;GO:0001649,osteoblast differentiation	hsa:7171,path:hsa04260,Cardiac muscle contraction;hsa:7171,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:7171,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:7171,path:hsa05414,Dilated cardiomyopathy (DCM)
PXDN_HUMAN	Q92626	PXDN	Peroxidasin homolog	0.965996982	0.897728659	1.499927395	2.595164675	0.9318628205	2.047546035	0.9318628205	2.047546035	0.45511202413576	0.184407	0	2.19726121694754	0.184742	0	GO:0062023,collagen-containing extracellular matrix;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0019806,bromide peroxidase activity;GO:0005201,extracellular matrix structural constituent;GO:0020037,heme binding;GO:0005152,interleukin-1 receptor antagonist activity;GO:0046872,metal ion binding;GO:0004601,peroxidase activity	GO:0070831,basement membrane assembly;GO:0030199,collagen fibril organization;GO:0030198,extracellular matrix organization;GO:0042744,hydrogen peroxide catabolic process;GO:0006955,immune response;GO:0006979,response to oxidative stress	
PHB_HUMAN	P35232	PHB	Prohibitin	11.24659965	14.4761957	11.91836375	10.79158845	12.861397675	11.3549761	12.861397675	11.3549761	1.13266620393855	0.392485	0	0.88287263849028	0.392203	0	GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0005769,early endosome;GO:0070062,extracellular exosome;GO:0031315,extrinsic component of mitochondrial outer membrane;GO:0098891,extrinsic component of presynaptic active zone membrane;GO:0098982,GABA-ergic synapse;GO:0098978,glutamatergic synapse;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0030061,mitochondrial crista;GO:0005743,mitochondrial inner membrane;GO:0035632,mitochondrial prohibitin complex;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0014069,postsynaptic density	GO:0001850,complement component C3a binding;GO:0001851,complement component C3b binding;GO:0019899,enzyme binding;GO:0042826,histone deacetylase binding;GO:0008022,protein C-terminus binding;GO:0046982,protein heterodimerization activity;GO:0031871,proteinase activated receptor binding;GO:0003714,transcription corepressor activity	GO:0007202,activation of phospholipase C activity;GO:1990051,activation of protein kinase C activity;GO:0031100,animal organ regeneration;GO:0140374,antiviral innate immune response;GO:0042113,B cell activation;GO:0023035,CD40 signaling pathway;GO:0071354,cellular response to interleukin-6;GO:0071897,DNA biosynthetic process;GO:0016575,histone deacetylation;GO:0006851,mitochondrial calcium ion transmembrane transport;GO:0007005,mitochondrion organization;GO:0044830,modulation by host of viral RNA genome replication;GO:0060766,negative regulation of androgen receptor signaling pathway;GO:0043066,negative regulation of apoptotic process;GO:0030308,negative regulation of cell growth;GO:0008285,negative regulation of cell population proliferation;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:2000323,negative regulation of glucocorticoid receptor signaling pathway;GO:0042177,negative regulation of protein catabolic process;GO:0010944,negative regulation of transcription by competitive promoter binding;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0001649,osteoblast differentiation;GO:0001552,ovarian follicle atresia;GO:0001541,ovarian follicle development;GO:0010942,positive regulation of cell death;GO:0045917,positive regulation of complement activation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0045745,positive regulation of G protein-coupled receptor signaling pathway;GO:0010628,positive regulation of gene expression;GO:0002639,positive regulation of immunoglobulin production;GO:0032740,positive regulation of interleukin-17 production;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:0051897,positive regulation of protein kinase B signaling;GO:0048661,positive regulation of smooth muscle cell proliferation;GO:0045893,positive regulation of transcription, DNA-templated;GO:0050847,progesterone receptor signaling pathway;GO:0050821,protein stabilization;GO:0042981,regulation of apoptotic process;GO:0006355,regulation of transcription, DNA-templated;GO:0042493,response to drug;GO:0045471,response to ethanol;GO:0035902,response to immobilization stress;GO:0043434,response to peptide hormone;GO:0039529,RIG-I signaling pathway;GO:0007165,signal transduction;GO:0072538,T-helper 17 type immune response;GO:0046718,viral entry into host cell	
NDUS3_HUMAN	O75489	NDUFS3	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	1.874156052	1.478367865	2.662296468	0.592367834	1.6762619585	1.627332151	1.6762619585	1.627332151	1.0300674988016	0.423551	0	0.970810166482699	0.423333	0	GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0031966,mitochondrial membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion;GO:0016604,nuclear body	GO:0009055,electron transfer activity;GO:0008137,NADH dehydrogenase (ubiquinone) activity;GO:0003954,NADH dehydrogenase activity	GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0030308,negative regulation of cell growth;GO:2001243,negative regulation of intrinsic apoptotic signaling pathway;GO:0072593,reactive oxygen species metabolic process;GO:0021762,substantia nigra development	hsa:4722,path:hsa00190,Oxidative phosphorylation;hsa:4722,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4722,path:hsa04714,Thermogenesis;hsa:4722,path:hsa05010,Alzheimer disease;hsa:4722,path:hsa05012,Parkinson disease;hsa:4722,path:hsa05016,Huntington disease;hsa:4722,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
UBA5_HUMAN	Q9GZZ9	UBA5	Ubiquitin-like modifier-activating enzyme 5	0.237069197	0.138330923	0.543436775	0.190684173	0.18770006	0.367060474	0.18770006	0.367060474	0.511360043631394	0.235573	0	1.95556929496986	0.235898	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0042803,protein homodimerization activity;GO:0071566,UFM1 activating enzyme activity;GO:0008270,zinc ion binding;GO:0046872,metal ion binding;GO:0008641,ubiquitin-like modifier activating enzyme activity	GO:0030218,erythrocyte differentiation;GO:0030219,megakaryocyte differentiation;GO:0050905,neuromuscular process;GO:1990592,protein K69-linked ufmylation;GO:0032446,protein modification by small protein conjugation;GO:0071569,protein ufmylation;GO:0033146,regulation of intracellular estrogen receptor signaling pathway;GO:0034976,response to endoplasmic reticulum stress;GO:0061709,reticulophagy	
ADPRH_HUMAN	P54922	ADPRH	[Protein ADP-ribosylarginine] hydrolase	0.066852756	0.093295329	0.176837206	0.06101762	0.0800740425	0.118927413	0.0800740425	0.118927413	0.673301810575834	0.382023	0	1.48521804678464	0.382241	0	GO:0005776,autophagosome;GO:0005829,cytosol;GO:0005615,extracellular space;GO:0055037,recycling endosome	GO:0003875,ADP-ribosylarginine hydrolase activity;GO:0005096,GTPase activator activity;GO:0000287,magnesium ion binding;GO:0030955,potassium ion binding	GO:0090630,activation of GTPase activity;GO:0006464,cellular protein modification process;GO:0006886,intracellular protein transport;GO:0051725,protein de-ADP-ribosylation;GO:2000785,regulation of autophagosome assembly	
PCYOX_HUMAN	Q9UHG3	PCYOX1	Prenylcysteine oxidase 1	2.298810144	3.358728062	6.003713006	15.64762397	2.828769103	10.825668488	2.828769103	10.825668488	0.261302025471741	0.040349	-1	3.82698908741581	0.040543	1	GO:0070062,extracellular exosome;GO:0005764,lysosome;GO:0005886,plasma membrane;GO:0034361,very-low-density lipoprotein particle	GO:0001735,prenylcysteine oxidase activity	GO:0006821,chloride transport;GO:0030327,prenylated protein catabolic process;GO:0030328,prenylcysteine catabolic process	hsa:51449,path:hsa00900,Terpenoid backbone biosynthesis
CPPED_HUMAN	Q9BRF8	CPPED1	Serine/threonine-protein phosphatase CPPED1	0.824576903	0.474314866	0.363601599	1.069853099	0.6494458845	0.716727349	0.6494458845	0.716727349	0.906126835268846	0.466225	0	1.10359826138832	0.466100	0	GO:0035578,azurophil granule lumen;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0005886,plasma membrane	GO:0046872,metal ion binding;GO:0106306,protein serine phosphatase activity;GO:0106307,protein threonine phosphatase activity	GO:0043312,neutrophil degranulation	
LPCT4_HUMAN	Q643R3	LPCAT4	Lysophospholipid acyltransferase LPCAT4	0.033609385	2.55E-05	0.022612697	2.55E-05	0.0168174425	0.0113190985	0.0168174425	0.0113190985	1.48575811934139	0.307989	0	0.673057065603168	0.307551	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0047184,1-acylglycerophosphocholine O-acyltransferase activity;GO:0106262,1-acylglycerophosphoethanolamine O-acyltransferase activity;GO:0106263,1-acylglycerophosphoserine O-acyltransferase activity;GO:0047166,1-alkenylglycerophosphoethanolamine O-acyltransferase activity;GO:0047192,1-alkylglycerophosphocholine O-acetyltransferase activity;GO:0071617,lysophospholipid acyltransferase activity;GO:0016746,transferase activity, transferring acyl groups	GO:0006654,phosphatidic acid biosynthetic process;GO:0036151,phosphatidylcholine acyl-chain remodeling;GO:0036152,phosphatidylethanolamine acyl-chain remodeling;GO:0036148,phosphatidylglycerol acyl-chain remodeling;GO:0036150,phosphatidylserine acyl-chain remodeling;GO:0006644,phospholipid metabolic process	hsa:254531,path:hsa00564,Glycerophospholipid metabolism;hsa:254531,path:hsa00565,Ether lipid metabolism
RAB4B_HUMAN	P61018	RAB4B	Ras-related protein Rab-4B	0.473697155	24.30723788	0.163943419	0.02639076	12.3904675175	0.0951670895	12.3904675175	0.0951670895	130.196978625683	0.000010	1	0.00768066978631664	0.000009	-1	GO:0005768,endosome;GO:0032593,insulin-responsive compartment;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0055037,recycling endosome;GO:0030667,secretory granule membrane	GO:0003925,G protein activity;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0046323,glucose import;GO:0043312,neutrophil degranulation;GO:0015031,protein transport;GO:0032482,Rab protein signal transduction;GO:0030100,regulation of endocytosis	
RT07_HUMAN	Q9Y2R9	MRPS7	28S ribosomal protein S7, mitochondrial	0.343438061	0.110336435	0.307485136	0.536851683	0.226887248	0.4221684095	0.226887248	0.4221684095	0.537433031213104	0.259588	0	1.86069694626469	0.259901	0	GO:0005743,mitochondrial inner membrane;GO:0005763,mitochondrial small ribosomal subunit;GO:0005840,ribosome	GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0019843,rRNA binding;GO:0003735,structural constituent of ribosome	GO:0032543,mitochondrial translation;GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination;GO:0000028,ribosomal small subunit assembly;GO:0006412,translation	hsa:51081,path:hsa03010,Ribosome
PCBP1_HUMAN	Q15365	PCBP1	Poly(rC)-binding protein 1	14.53883546	25.93390769	14.9133167	12.10801711	20.236371575	13.510666905	20.236371575	13.510666905	1.49780700814339	0.305598	0	0.667642756752454	0.305156	0	GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0045296,cadherin binding;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0098847,sequence-specific single stranded DNA binding;GO:0003697,single-stranded DNA binding	GO:0000398,mRNA splicing, via spliceosome;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0010468,regulation of gene expression;GO:0051252,regulation of RNA metabolic process;GO:0016070,RNA metabolic process;GO:0039694,viral RNA genome replication	hsa:5093,path:hsa03040,Spliceosome;hsa:5093,path:hsa04216,Ferroptosis
ABCE1_HUMAN	P61221	ABCE1	ATP-binding cassette sub-family E member 1	1.323863709	0.865011619	1.556674427	0.695819763	1.094437664	1.126247095	1.094437664	1.126247095	0.971756259224802	0.442869	0	1.02906463478581	0.442692	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0051539,4 iron, 4 sulfur cluster binding;GO:0005524,ATP binding;GO:0042626,ATPase-coupled transmembrane transporter activity;GO:0060698,endoribonuclease inhibitor activity;GO:0005506,iron ion binding;GO:0043024,ribosomal small subunit binding	GO:0051607,defense response to virus;GO:0060702,negative regulation of endoribonuclease activity;GO:0006417,regulation of translation;GO:0060338,regulation of type I interferon-mediated signaling pathway;GO:0000054,ribosomal subunit export from nucleus;GO:0006413,translational initiation;GO:0006415,translational termination;GO:0016032,viral process	
CAH1_HUMAN	P00915	CA1	Carbonic anhydrase 1	9.855327357	44.57735253	29.75463787	266.4986023	27.2163399435	148.126620085	27.2163399435	148.126620085	0.183736994254526	0.011161	-1	5.44256209293773	0.011245	1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0004064,arylesterase activity;GO:0004089,carbonate dehydratase activity;GO:0016836,hydro-lyase activity;GO:0008270,zinc ion binding	GO:0015701,bicarbonate transport;GO:0035722,interleukin-12-mediated signaling pathway;GO:0006730,one-carbon metabolic process	hsa:759,path:hsa00910,Nitrogen metabolism
GORS2_HUMAN	Q9H8Y8	GORASP2	Golgi reassembly-stacking protein 2	0.347532883	0.189555015	0.433361742	0.175362463	0.268543949	0.3043621025	0.268543949	0.3043621025	0.882317301642375	0.475154	0	1.13337911218398	0.475049	0	GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016020,membrane		GO:0030154,cell differentiation;GO:0061951,establishment of protein localization to plasma membrane;GO:0007030,Golgi organization;GO:0070925,organelle assembly;GO:0006996,organelle organization;GO:0034976,response to endoplasmic reticulum stress;GO:0007283,spermatogenesis	
LMNA_HUMAN	P02545	LMNA	Prelamin-A/C	136.5914563	268.8519088	137.5038626	346.2301447	202.72168255	241.86700365	202.72168255	241.86700365	0.838153528553873	0.492405	0	1.19309883682691	0.492338	0	GO:0005829,cytosol;GO:0005882,intermediate filament;GO:0005638,lamin filament;GO:0016604,nuclear body;GO:0005635,nuclear envelope;GO:0005652,nuclear lamina;GO:0016363,nuclear matrix;GO:0031965,nuclear membrane;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0035861,site of double-strand break	GO:0042802,identical protein binding;GO:0005198,structural molecule activity	GO:0034613,cellular protein localization;GO:0071456,cellular response to hypoxia;GO:1990683,DNA double-strand break attachment to nuclear envelope;GO:0030951,establishment or maintenance of microtubule cytoskeleton polarity;GO:0036498,IRE1-mediated unfolded protein response;GO:0007084,mitotic nuclear envelope reassembly;GO:0007517,muscle organ development;GO:1903243,negative regulation of cardiac muscle hypertrophy in response to stress;GO:0008285,negative regulation of cell population proliferation;GO:0006998,nuclear envelope organization;GO:0090343,positive regulation of cell aging;GO:0034504,protein localization to nucleus;GO:0030334,regulation of cell migration;GO:0032204,regulation of telomere maintenance	hsa:4000,path:hsa04210,Apoptosis;hsa:4000,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:4000,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:4000,path:hsa05414,Dilated cardiomyopathy (DCM)
YBOX1_HUMAN	P67809	YBX1	Y-box-binding protein 1	1.057021026	0.504191487	0.846409185	0.209791377	0.7806062565	0.528100281	0.7806062565	0.528100281	1.47814020288317	0.309515	0	0.676525811319833	0.309079	0	GO:0070937,CRD-mediated mRNA stability complex;GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0071204,histone pre-mRNA 3'end processing complex;GO:0043231,intracellular membrane-bounded organelle;GO:1990124,messenger ribonucleoprotein complex;GO:0031965,nuclear membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0005689,U12-type spliceosomal complex	GO:0062153,C5-methylcytidine-containing RNA binding;GO:0003677,DNA binding;GO:0003690,double-stranded DNA binding;GO:0051020,GTPase binding;GO:0035198,miRNA binding;GO:0003676,nucleic acid binding;GO:0003723,RNA binding;GO:1990837,sequence-specific double-stranded DNA binding	GO:0070934,CRD-mediated mRNA stabilization;GO:0048598,embryonic morphogenesis;GO:0008544,epidermis development;GO:1990428,miRNA transport;GO:0000398,mRNA splicing, via spliceosome;GO:0048255,mRNA stabilization;GO:2000773,negative regulation of cellular senescence;GO:0017148,negative regulation of translation;GO:0007219,Notch signaling pathway;GO:0051781,positive regulation of cell division;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:1903608,protein localization to cytoplasmic stress granule;GO:0010468,regulation of gene expression;GO:0006355,regulation of transcription, DNA-templated;GO:0050658,RNA transport;GO:0051031,tRNA transport	
STA5A_HUMAN	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.019822411	0.034733664	0.060661305	1.682494832	0.0272780375	0.8715780685	0.0272780375	0.8715780685	0.0312972968066371	0.000000	-1	31.9516412608495	0.000000	1	GO:0000785,chromatin;GO:0005829,cytosol;GO:0005654,nucleoplasm	GO:0003700,DNA-binding transcription factor activity;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677,DNA binding	GO:0019221,cytokine-mediated signaling pathway;GO:0006952,defense response;GO:0060397,growth hormone receptor signaling pathway via JAK-STAT;GO:0035723,interleukin-15-mediated signaling pathway;GO:0038110,interleukin-2-mediated signaling pathway;GO:0038111,interleukin-7-mediated signaling pathway;GO:0038113,interleukin-9-mediated signaling pathway;GO:0007595,lactation;GO:0043536,positive regulation of blood vessel endothelial cell migration;GO:0001938,positive regulation of endothelial cell proliferation;GO:0007259,receptor signaling pathway via JAK-STAT;GO:0038026,reelin-mediated signaling pathway;GO:0042127,regulation of cell population proliferation;GO:0040014,regulation of multicellular organism growth;GO:0006357,regulation of transcription by RNA polymerase II;GO:0043434,response to peptide hormone;GO:0019530,taurine metabolic process	hsa:6776,path:hsa04012,ErbB signaling pathway;hsa:6776,path:hsa04630,Jak-STAT signaling pathway;hsa:6776,path:hsa04217,Necroptosis;hsa:6776,path:hsa04658,Th1 and Th2 cell differentiation;hsa:6776,path:hsa04659,Th17 cell differentiation;hsa:6776,path:hsa04917,Prolactin signaling pathway;hsa:6776,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:6776,path:hsa05200,Pathways in cancer;hsa:6776,path:hsa05203,Viral carcinogenesis;hsa:6776,path:hsa05221,Acute myeloid leukemia;hsa:6776,path:hsa05220,Chronic myeloid leukemia;hsa:6776,path:hsa05223,Non-small cell lung cancer;hsa:6776,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:6776,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:6776,path:hsa05162,Measles;hsa:6776,path:hsa05161,Hepatitis B
ECHA_HUMAN	P40939	HADHA	Trifunctional enzyme subunit alpha, mitochondrial	12.88582962	21.44094872	22.76907291	22.25589483	17.16338917	22.51248387	17.16338917	22.51248387	0.762394290612767	0.456101	0	1.31165725178275	0.456241	0	GO:0016507,mitochondrial fatty acid beta-oxidation multienzyme complex;GO:0005743,mitochondrial inner membrane;GO:0042645,mitochondrial nucleoid;GO:0005739,mitochondrion	GO:0003857,3-hydroxyacyl-CoA dehydrogenase activity;GO:0003985,acetyl-CoA C-acetyltransferase activity;GO:0004300,enoyl-CoA hydratase activity;GO:0016509,long-chain-3-hydroxyacyl-CoA dehydrogenase activity;GO:0070403,NAD+ binding;GO:0003988,acetyl-CoA C-acyltransferase activity;GO:0000062,fatty-acyl-CoA binding;GO:0016508,long-chain-enoyl-CoA hydratase activity;GO:0044877,protein-containing complex binding;GO:0003824,catalytic activity	GO:0035965,cardiolipin acyl-chain remodeling;GO:0006635,fatty acid beta-oxidation;GO:0042493,response to drug;GO:0006631,fatty acid metabolic process	hsa:3030,path:hsa00640,Propanoate metabolism;hsa:3030,path:hsa00650,Butanoate metabolism;hsa:3030,path:hsa00062,Fatty acid elongation;hsa:3030,path:hsa00071,Fatty acid degradation;hsa:3030,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:3030,path:hsa00310,Lysine degradation;hsa:3030,path:hsa00380,Tryptophan metabolism;hsa:3030,path:hsa00410,beta-Alanine metabolism
MPRI_HUMAN	P11717	IGF2R	Cation-independent mannose-6-phosphate receptor	0.70784441	0.66813556	1.192656763	0.91991532	0.687989985	1.0562860415	0.687989985	1.0562860415	0.65132924034763	0.362840	0	1.53532182812225	0.363077	0	GO:0009986,cell surface;GO:0030118,clathrin coat;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0005769,early endosome;GO:0030139,endocytic vesicle;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0005770,late endosome;GO:0016020,membrane;GO:0005641,nuclear envelope lumen;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0005802,trans-Golgi network;GO:0032588,trans-Golgi network membrane;GO:0030140,trans-Golgi network transport vesicle;GO:0030133,transport vesicle	GO:0019899,enzyme binding;GO:0001965,G-protein alpha-subunit binding;GO:0042802,identical protein binding;GO:0005520,insulin-like growth factor binding;GO:0031995,insulin-like growth factor II binding;GO:0005010,insulin-like growth factor-activated receptor activity;GO:0005537,mannose binding;GO:0051219,phosphoprotein binding;GO:0001972,retinoic acid binding;GO:1905394,retromer complex binding;GO:0038023,signaling receptor activity	GO:0031100,animal organ regeneration;GO:0007186,G protein-coupled receptor signaling pathway;GO:0001889,liver development;GO:0007041,lysosomal transport;GO:0061024,membrane organization;GO:0043312,neutrophil degranulation;GO:0044794,positive regulation by host of viral process;GO:0043065,positive regulation of apoptotic process;GO:0009791,post-embryonic development;GO:0006898,receptor-mediated endocytosis;GO:0032526,response to retinoic acid;GO:1904772,response to tetrachloromethane;GO:0007165,signal transduction;GO:0007283,spermatogenesis	hsa:3482,path:hsa04144,Endocytosis;hsa:3482,path:hsa04142,Lysosome
UAP1_HUMAN	Q16222	UAP1	UDP-N-acetylhexosamine pyrophosphorylase	0.128076897	0.094200601	0.115016657	2.55E-05	0.111138749	0.0575210785	0.111138749	0.0575210785	1.93213951995006	0.234846	0	0.517560967867292	0.234311	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0030246,carbohydrate binding;GO:0042802,identical protein binding;GO:0052630,UDP-N-acetylgalactosamine diphosphorylase activity;GO:0003977,UDP-N-acetylglucosamine diphosphorylase activity	GO:0006048,UDP-N-acetylglucosamine biosynthetic process	hsa:6675,path:hsa00520,Amino sugar and nucleotide sugar metabolism
FUBP2_HUMAN	Q92945	KHSRP	Far upstream element-binding protein 2	8.06093411	4.878896112	10.6671307	30.6230488	6.469915111	20.64508975	6.469915111	20.64508975	0.313387599150544	0.070933	0	3.1909367272686	0.071193	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0010494,cytoplasmic stress granule	GO:0003677,DNA binding;GO:0035925,mRNA 3'-UTR AU-rich region binding;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0003676,nucleic acid binding	GO:0061158,3'-UTR-mediated mRNA destabilization;GO:0071345,cellular response to cytokine stimulus;GO:0010586,miRNA metabolic process;GO:0006397,mRNA processing;GO:0051028,mRNA transport;GO:0010989,negative regulation of low-density lipoprotein particle clearance;GO:0045019,negative regulation of nitric oxide biosynthetic process;GO:0061014,positive regulation of mRNA catabolic process;GO:0010468,regulation of gene expression;GO:0043488,regulation of mRNA stability;GO:0006355,regulation of transcription, DNA-templated;GO:0008380,RNA splicing;GO:0000375,RNA splicing, via transesterification reactions;GO:0006402,mRNA catabolic process;GO:2000628,regulation of miRNA metabolic process	
MRC2_HUMAN	Q9UBG0	MRC2	C-type mannose receptor 2	0.257035324	0.492035287	0.48403414	1.050036074	0.3745353055	0.767035107	0.3745353055	0.767035107	0.488289652040659	0.214424	0	2.04796475989364	0.214755	0	GO:0005925,focal adhesion;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0030246,carbohydrate binding;GO:0005518,collagen binding;GO:0038023,signaling receptor activity	GO:0030574,collagen catabolic process;GO:0006897,endocytosis;GO:0001649,osteoblast differentiation	hsa:9902,path:hsa04145,Phagosome;hsa:9902,path:hsa05152,Tuberculosis
CDS2_HUMAN	O95674	CDS2	Phosphatidate cytidylyltransferase 2	0.088649432	0.048224219	0.309356181	0.199706162	0.0684368255	0.2545311715	0.0684368255	0.2545311715	0.268874044372204	0.044284	-1	3.71921359064207	0.044489	1	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005743,mitochondrial inner membrane	GO:0004605,phosphatidate cytidylyltransferase activity	GO:0016024,CDP-diacylglycerol biosynthetic process;GO:0140042,lipid droplet formation;GO:0006655,phosphatidylglycerol biosynthetic process	hsa:8760,path:hsa00564,Glycerophospholipid metabolism;hsa:8760,path:hsa04070,Phosphatidylinositol signaling system
CD63_HUMAN	P08962	CD63	CD63 antigen	1.949516232	2.759639446	2.777660745	4.552809295	2.354577839	3.66523502	2.354577839	3.66523502	0.64240842023822	0.354964	0	1.55664211192807	0.355208	0	GO:0035577,azurophil granule membrane;GO:0009986,cell surface;GO:0031904,endosome lumen;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005887,integral component of plasma membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0031226,intrinsic component of plasma membrane;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0042470,melanosome;GO:0032585,multivesicular body membrane;GO:0097487,multivesicular body, internal vesicle;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0031088,platelet dense granule membrane;GO:0016021,integral component of membrane;GO:0005576,extracellular region;GO:0005771,multivesicular body		GO:0016477,cell migration;GO:0007160,cell-matrix adhesion;GO:0034613,cellular protein localization;GO:0035646,endosome to melanosome transport;GO:0043312,neutrophil degranulation;GO:0048757,pigment granule maturation;GO:0002576,platelet degranulation;GO:2001046,positive regulation of integrin-mediated signaling pathway;GO:0002092,positive regulation of receptor internalization;GO:0015031,protein transport;GO:1901379,regulation of potassium ion transmembrane transport;GO:1900746,regulation of vascular endothelial growth factor signaling pathway	hsa:967,path:hsa04142,Lysosome;hsa:967,path:hsa05205,Proteoglycans in cancer
BCR_HUMAN	P11274	BCR	Breakpoint cluster region protein	0.109325358	0.059137969	0.062563703	0.50778896	0.0842316635	0.2851763315	0.0842316635	0.2851763315	0.295366950885964	0.059453	0	3.38561913240619	0.059692	0	GO:0030424,axon;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0016020,membrane;GO:0099092,postsynaptic density, intracellular component;GO:0032991,protein-containing complex;GO:0098685,Schaffer collateral - CA1 synapse	GO:0005524,ATP binding;GO:0019899,enzyme binding;GO:0005096,GTPase activator activity;GO:0005085,guanyl-nucleotide exchange factor activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity	GO:0090630,activation of GTPase activity;GO:0048041,focal adhesion assembly;GO:0030216,keratinocyte differentiation;GO:0050804,modulation of chemical synaptic transmission;GO:0048008,platelet-derived growth factor receptor signaling pathway;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:0035023,regulation of Rho protein signal transduction;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007165,signal transduction;GO:0007264,small GTPase mediated signal transduction;GO:0035556,intracellular signal transduction;GO:0043547,positive regulation of GTPase activity	hsa:613,path:hsa05200,Pathways in cancer;hsa:613,path:hsa05220,Chronic myeloid leukemia
UN13D_HUMAN	Q70J99	UNC13D	Protein unc-13 homolog D	0.388357396	0.371791399	0.352531934	0.476522414	0.3800743975	0.414527174	0.3800743975	0.414527174	0.916886567007064	0.462272	0	1.09064745409483	0.462138	0	GO:0035578,azurophil granule lumen;GO:0005829,cytosol;GO:0070382,exocytic vesicle;GO:0005576,extracellular region;GO:0043231,intracellular membrane-bounded organelle;GO:0005770,late endosome;GO:0005764,lysosome;GO:0016020,membrane;GO:0055037,recycling endosome;GO:0033093,Weibel-Palade body	GO:0046872,metal ion binding;GO:0031267,small GTPase binding	GO:0051607,defense response to virus;GO:0002467,germinal center formation;GO:0002432,granuloma formation;GO:0043320,natural killer cell degranulation;GO:0043312,neutrophil degranulation;GO:0006909,phagocytosis;GO:0045921,positive regulation of exocytosis;GO:1903307,positive regulation of regulated secretory pathway;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0043304,regulation of mast cell degranulation;GO:0006887,exocytosis	
SNW1_HUMAN	Q13573	SNW1	SNW domain-containing protein 1	0.056456987	0.043251005	0.050877942	2.55E-05	0.049853996	0.025451721	0.049853996	0.025451721	1.95876718906356	0.231316	0	0.510525194409692	0.230779	0	GO:0071013,catalytic step 2 spliceosome;GO:0016604,nuclear body;GO:0016363,nuclear matrix;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0071007,U2-type catalytic step 2 spliceosome;GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0071141,SMAD protein complex	GO:0050681,androgen receptor binding;GO:0019899,enzyme binding;GO:0005112,Notch binding;GO:0035257,nuclear hormone receptor binding;GO:0042974,retinoic acid receptor binding;GO:0003723,RNA binding;GO:0046332,SMAD binding;GO:0003713,transcription coactivator activity;GO:0003714,transcription corepressor activity;GO:0042809,vitamin D receptor binding	GO:0071300,cellular response to retinoic acid;GO:0042771,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0000398,mRNA splicing, via spliceosome;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0007219,Notch signaling pathway;GO:0043923,positive regulation by host of viral transcription;GO:0051571,positive regulation of histone H3-K4 methylation;GO:0048026,positive regulation of mRNA splicing, via spliceosome;GO:0050769,positive regulation of neurogenesis;GO:0045747,positive regulation of Notch signaling pathway;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0007221,positive regulation of transcription of Notch receptor target;GO:0030511,positive regulation of transforming growth factor beta receptor signaling pathway;GO:0070564,positive regulation of vitamin D receptor signaling pathway;GO:0048385,regulation of retinoic acid receptor signaling pathway;GO:0006357,regulation of transcription by RNA polymerase II;GO:0070562,regulation of vitamin D receptor signaling pathway;GO:0048384,retinoic acid receptor signaling pathway;GO:0006367,transcription initiation from RNA polymerase II promoter;GO:0016032,viral process;GO:0014010,Schwann cell proliferation	hsa:22938,path:hsa03040,Spliceosome;hsa:22938,path:hsa04330,Notch signaling pathway;hsa:22938,path:hsa05203,Viral carcinogenesis;hsa:22938,path:hsa05169,Epstein-Barr virus infection
SNX1_HUMAN	Q13596	SNX1	Sorting nexin-1	1.234950713	1.47790167	1.992428926	2.395502445	1.3564261915	2.1939656855	1.3564261915	2.1939656855	0.618253147925089	0.333407	0	1.61746042596966	0.333670	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0030027,lamellipodium;GO:0005764,lysosome;GO:0016020,membrane;GO:0032991,protein-containing complex;GO:0030904,retromer complex;GO:0030905,retromer, tubulation complex;GO:0031982,vesicle	GO:0045296,cadherin binding;GO:0005154,epidermal growth factor receptor binding;GO:0042802,identical protein binding;GO:0005158,insulin receptor binding;GO:1990460,leptin receptor binding;GO:0035091,phosphatidylinositol binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:1990459,transferrin receptor binding	GO:0034498,early endosome to Golgi transport;GO:0006886,intracellular protein transport;GO:0072673,lamellipodium morphogenesis;GO:0045732,positive regulation of protein catabolic process;GO:0031623,receptor internalization;GO:0042147,retrograde transport, endosome to Golgi	hsa:6642,path:hsa04144,Endocytosis
LAP2B_HUMAN	P42167	TMPO	Lamina-associated polypeptide 2, isoforms beta/gamma	1.879236097	1.54538575	1.809497503	0.851259946	1.7123109235	1.3303787245	1.7123109235	1.3303787245	1.28708531786206	0.351761	0	0.776949271444626	0.351399	0	GO:0005737,cytoplasm;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0005637,nuclear inner membrane;GO:0031965,nuclear membrane;GO:0005634,nucleus;GO:0000785,chromatin	GO:0003677,DNA binding;GO:0005521,lamin binding;GO:0045296,cadherin binding	GO:0006355,regulation of transcription, DNA-templated	
PSA6_HUMAN	P60900	PSMA6	Proteasome subunit alpha type-6	9.907198533	14.17710619	9.237793731	8.307199992	12.0421523615	8.7724968615	12.0421523615	8.7724968615	1.37271663377272	0.331832	0	0.728482467100032	0.331434	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0030016,myofibril;GO:0016363,nuclear matrix;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body;GO:0005844,polysome;GO:0000502,proteasome complex;GO:0005839,proteasome core complex;GO:0019773,proteasome core complex, alpha-subunit complex;GO:0030017,sarcomere	GO:0004175,endopeptidase activity;GO:0051059,NF-kappaB binding;GO:0035639,purine ribonucleoside triphosphate binding;GO:0003723,RNA binding	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0051603,proteolysis involved in cellular protein catabolic process;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:0050727,regulation of inflammatory response;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:5687,path:hsa03050,Proteasome
ACSS3_HUMAN	Q9H6R3	ACSS3	Acyl-CoA synthetase short-chain family member 3, mitochondrial	0.015891053	0.072048268	0.596877308	0.225295974	0.0439696605	0.411086641	0.0439696605	0.411086641	0.106959594680675	0.000930	-1	9.34932488277911	0.000942	1	GO:0043231,intracellular membrane-bounded organelle;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0003987,acetate-CoA ligase activity;GO:0005524,ATP binding;GO:0047760,butyrate-CoA ligase activity;GO:0050218,propionate-CoA ligase activity;GO:0000166,nucleotide binding	GO:0046951,ketone body biosynthetic process	hsa:79611,path:hsa00640,Propanoate metabolism
EI2BD_HUMAN	Q9UI10	EIF2B4	Translation initiation factor eIF-2B subunit delta	0.012342258	0.022296738	0.113977402	2.55E-05	0.017319498	0.057001451	0.017319498	0.057001451	0.303843107432476	0.064741	0	3.29117223836395	0.064990	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005851,eukaryotic translation initiation factor 2B complex	GO:0003743,translation initiation factor activity;GO:0031369,translation initiation factor binding	GO:0042552,myelination;GO:0014003,oligodendrocyte development;GO:0001541,ovarian follicle development;GO:0050790,regulation of catalytic activity;GO:0006417,regulation of translation;GO:0009749,response to glucose;GO:0009408,response to heat;GO:0043434,response to peptide hormone;GO:0050852,T cell receptor signaling pathway;GO:0006413,translational initiation;GO:0044237,cellular metabolic process	hsa:8890,path:hsa03013,RNA transport;hsa:8890,path:hsa05168,Herpes simplex virus 1 infection
RB33B_HUMAN	Q9H082	RAB33B	Ras-related protein Rab-33B	0.052123224	0.176956174	0.014293513	2.55E-05	0.114539699	0.0071595065	0.114539699	0.0071595065	15.9982673386776	0.006128	1	0.0625067689413083	0.006030	-1	GO:0005768,endosome;GO:0005794,Golgi apparatus;GO:0005796,Golgi lumen;GO:0000139,Golgi membrane;GO:0098793,presynapse	GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0006914,autophagy;GO:0006891,intra-Golgi vesicle-mediated transport;GO:1903434,negative regulation of constitutive secretory pathway;GO:0034067,protein localization to Golgi apparatus;GO:0015031,protein transport;GO:0032482,Rab protein signal transduction;GO:1903358,regulation of Golgi organization;GO:2000156,regulation of retrograde vesicle-mediated transport, Golgi to ER;GO:0048705,skeletal system morphogenesis;GO:0000045,autophagosome assembly	hsa:83452,path:hsa04140,Autophagy - animal
VKORL_HUMAN	Q8N0U8	VKORC1L1	Vitamin K epoxide reductase complex subunit 1-like protein 1	0.5776138	1.912576217	0.09528795	0.041017348	1.2450950085	0.068152649	1.2450950085	0.068152649	18.2692092936842	0.004441	1	0.0547369064486937	0.004364	-1	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane	GO:0048038,quinone binding;GO:0047057,vitamin-K-epoxide reductase (warfarin-sensitive) activity	GO:0034599,cellular response to oxidative stress;GO:0017187,peptidyl-glutamic acid carboxylation;GO:0042373,vitamin K metabolic process	hsa:154807,path:hsa00130,Ubiquinone and other terpenoid-quinone biosynthesis
FUS_HUMAN	P35637	FUS	RNA-binding protein FUS	1.365299334	1.092995634	1.646767485	0.841211556	1.229147484	1.2439895205	1.229147484	1.2439895205	0.988069001984812	0.437334	0	1.01207506559888	0.437146	0	GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0044327,dendritic spine head;GO:0043204,perikaryon;GO:0048471,perinuclear region of cytoplasm;GO:0005844,polysome	GO:0003682,chromatin binding;GO:0003677,DNA binding;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0003723,RNA binding;GO:0003713,transcription coactivator activity;GO:0003712,transcription coregulator activity;GO:0030331,estrogen receptor binding;GO:0035255,ionotropic glutamate receptor binding;GO:0003730,mRNA 3'-UTR binding;GO:0031489,myosin V binding;GO:0046965,retinoid X receptor binding;GO:0046966,thyroid hormone receptor binding	GO:0000398,mRNA splicing, via spliceosome;GO:0048255,mRNA stabilization;GO:1905168,positive regulation of double-strand break repair via homologous recombination;GO:0051260,protein homooligomerization;GO:0043484,regulation of RNA splicing;GO:0006357,regulation of transcription by RNA polymerase II;GO:0006355,regulation of transcription, DNA-templated;GO:0008380,RNA splicing;GO:0071277,cellular response to calcium ion	hsa:2521,path:hsa05202,Transcriptional misregulation in cancer
HBG2_HUMAN	P69892	HBG2	Hemoglobin subunit gamma-2	0.047938168	2.55E-05	0.03865428	2.60462655	0.023981834	1.321640415	0.023981834	1.321640415	0.0181455059392989	0.000000	-1	55.1100643512085	0.000000	1	GO:0072562,blood microparticle;GO:0005829,cytosol;GO:0031838,haptoglobin-hemoglobin complex;GO:0005833,hemoglobin complex	GO:0020037,heme binding;GO:0031721,hemoglobin alpha binding;GO:0046872,metal ion binding;GO:0043177,organic acid binding;GO:0019825,oxygen binding;GO:0005344,oxygen carrier activity	GO:0007596,blood coagulation;GO:0098869,cellular oxidant detoxification;GO:0042744,hydrogen peroxide catabolic process	
EMC3_HUMAN	Q9P0I2	EMC3	ER membrane protein complex subunit 3	0.218256385	0.232061555	0.26980485	2.55E-05	0.22515897	0.134915175	0.22515897	0.134915175	1.66889284322538	0.274410	0	0.599199645477149	0.273922	0	GO:0072546,EMC complex;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016021,integral component of membrane		GO:0045050,protein insertion into ER membrane by stop-transfer membrane-anchor sequence;GO:0071816,tail-anchored membrane protein insertion into ER membrane	
PNKP_HUMAN	Q96T60	PNKP	Bifunctional polynucleotide phosphatase/kinase	0.071761752	0.048374089	0.164860783	0.103181583	0.0600679205	0.134021183	0.0600679205	0.134021183	0.448197211481113	0.178239	0	2.2311606908383	0.178575	0	GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0046404,ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0003684,damaged DNA binding;GO:0003690,double-stranded DNA binding;GO:0004519,endonuclease activity;GO:0046403,polynucleotide 3'-phosphatase activity;GO:0017076,purine nucleotide binding	GO:0006287,base-excision repair, gap-filling;GO:0016311,dephosphorylation;GO:0042769,DNA damage response, detection of DNA damage;GO:0006281,DNA repair;GO:0006261,DNA-dependent DNA replication;GO:0010836,negative regulation of protein ADP-ribosylation;GO:0046939,nucleotide phosphorylation;GO:0000718,nucleotide-excision repair, DNA damage removal;GO:2001034,positive regulation of double-strand break repair via nonhomologous end joining;GO:0051973,positive regulation of telomerase activity;GO:1904355,positive regulation of telomere capping;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:0006979,response to oxidative stress;GO:0009314,response to radiation	
CUL4B_HUMAN	Q13620	CUL4B	Cullin-4B	1.171504501	0.719821665	1.413122474	0.721126732	0.945663083	1.067124603	0.945663083	1.067124603	0.886178690231173	0.473689	0	1.12844058542994	0.473580	0	GO:0080008,Cul4-RING E3 ubiquitin ligase complex;GO:0031465,Cul4B-RING E3 ubiquitin ligase complex;GO:0031461,cullin-RING ubiquitin ligase complex;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0019005,SCF ubiquitin ligase complex	GO:0031625,ubiquitin protein ligase binding;GO:0004842,ubiquitin-protein transferase activity	GO:0006974,cellular response to DNA damage stimulus;GO:0042769,DNA damage response, detection of DNA damage;GO:0000082,G1/S transition of mitotic cell cycle;GO:0070911,global genome nucleotide-excision repair;GO:0035518,histone H2A monoubiquitination;GO:0000715,nucleotide-excision repair, DNA damage recognition;GO:0000717,nucleotide-excision repair, DNA duplex unwinding;GO:0033683,nucleotide-excision repair, DNA incision;GO:0006295,nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006294,nucleotide-excision repair, preincision complex assembly;GO:0006293,nucleotide-excision repair, preincision complex stabilization;GO:0043687,post-translational protein modification;GO:0010498,proteasomal protein catabolic process;GO:0016567,protein ubiquitination;GO:0042254,ribosome biogenesis;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0070914,UV-damage excision repair;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:8450,path:hsa04120,Ubiquitin mediated proteolysis;hsa:8450,path:hsa03420,Nucleotide excision repair;hsa:8450,path:hsa05170,Human immunodeficiency virus 1 infection
KC1D_HUMAN	P48730	CSNK1D	Casein kinase I isoform delta	0.113179754	0.030088458	0.125989964	0.046818296	0.071634106	0.08640413	0.071634106	0.08640413	0.829058819294865	0.496074	0	1.20618703610261	0.496015	0	GO:0005813,centrosome;GO:0036064,ciliary basal body;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005794,Golgi apparatus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0005819,spindle;GO:0005876,spindle microtubule;GO:0043005,neuron projection	GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0050321,tau-protein kinase activity	GO:0097711,ciliary basal body-plasma membrane docking;GO:0032922,circadian regulation of gene expression;GO:0048208,COPII vesicle coating;GO:0000086,G2/M transition of mitotic cell cycle;GO:0007030,Golgi organization;GO:0007020,microtubule nucleation;GO:1905515,non-motile cilium assembly;GO:0018105,peptidyl-serine phosphorylation;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:2000052,positive regulation of non-canonical Wnt signaling pathway;GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0001934,positive regulation of protein phosphorylation;GO:1905426,positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation;GO:0071539,protein localization to centrosome;GO:0061512,protein localization to cilium;GO:0034067,protein localization to Golgi apparatus;GO:0006468,protein phosphorylation;GO:0042752,regulation of circadian rhythm;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0051225,spindle assembly;GO:0016055,Wnt signaling pathway;GO:1990090,cellular response to nerve growth factor stimulus	hsa:1453,path:hsa04340,Hedgehog signaling pathway;hsa:1453,path:hsa04390,Hippo signaling pathway;hsa:1453,path:hsa04540,Gap junction;hsa:1453,path:hsa04710,Circadian rhythm
SRSF9_HUMAN	Q13242	SRSF9	Serine/arginine-rich splicing factor 9	1.14492866	1.543710409	0.583780356	0.246290779	1.3443195345	0.4150355675	1.3443195345	0.4150355675	3.23904657761651	0.123341	0	0.308732824933892	0.122788	0	GO:0016607,nuclear speck;GO:0005730,nucleolus;GO:0005654,nucleoplasm	GO:0019904,protein domain specific binding;GO:0003723,RNA binding	GO:0000380,alternative mRNA splicing, via spliceosome;GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0006397,mRNA processing;GO:0006376,mRNA splice site selection;GO:0000398,mRNA splicing, via spliceosome;GO:0048025,negative regulation of mRNA splicing, via spliceosome;GO:0043279,response to alkaloid;GO:0009636,response to toxic substance;GO:0006405,RNA export from nucleus	hsa:8683,path:hsa03040,Spliceosome;hsa:8683,path:hsa05168,Herpes simplex virus 1 infection
CAP7_HUMAN	P20160	AZU1	Azurocidin	1.083303469	5.472471943	0.92297398	3.58881406	3.277887706	2.25589402	3.277887706	2.25589402	1.45303266773144	0.314624	0	0.68821577257534	0.314196	0	GO:0042582,azurophil granule;GO:0035578,azurophil granule lumen;GO:0035577,azurophil granule membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0019898,extrinsic component of membrane;GO:0043231,intracellular membrane-bounded organelle	GO:0043395,heparan sulfate proteoglycan binding;GO:0008201,heparin binding;GO:0008233,peptidase activity;GO:0004252,serine-type endopeptidase activity;GO:0015643,toxic substance binding	GO:0019730,antimicrobial humoral response;GO:0035584,calcium-mediated signaling using intracellular calcium source;GO:0060326,cell chemotaxis;GO:0045123,cellular extravasation;GO:0050829,defense response to Gram-negative bacterium;GO:0051607,defense response to virus;GO:0008347,glial cell migration;GO:0050930,induction of positive chemotaxis;GO:0006954,inflammatory response;GO:0048246,macrophage chemotaxis;GO:0001774,microglial cell activation;GO:0042117,monocyte activation;GO:0043066,negative regulation of apoptotic process;GO:0043312,neutrophil degranulation;GO:0070944,neutrophil-mediated killing of bacterium;GO:0045785,positive regulation of cell adhesion;GO:0032724,positive regulation of fractalkine production;GO:0010628,positive regulation of gene expression;GO:0032731,positive regulation of interleukin-1 beta production;GO:0045348,positive regulation of MHC class II biosynthetic process;GO:0010800,positive regulation of peptidyl-threonine phosphorylation;GO:0050766,positive regulation of phagocytosis;GO:0045860,positive regulation of protein kinase activity;GO:0032760,positive regulation of tumor necrosis factor production;GO:0070528,protein kinase C signaling;GO:0007205,protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0006508,proteolysis;GO:0043114,regulation of vascular permeability	
ANXA2_HUMAN	P07355	ANXA2	Annexin A2	148.8662666	479.017378	192.8854752	395.4217386	313.9418223	294.1536069	313.9418223	294.1536069	1.06727170748828	0.411875	0	0.936968527305385	0.411633	0	GO:0005912,adherens junction;GO:1990665,AnxA2-p11 complex;GO:0035578,azurophil granule lumen;GO:0005604,basement membrane;GO:0016323,basolateral plasma membrane;GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0031902,late endosome membrane;GO:0005811,lipid droplet;GO:0005765,lysosomal membrane;GO:0042470,melanosome;GO:0016020,membrane;GO:0030496,midbody;GO:0005634,nucleus;GO:1990667,PCSK9-AnxA2 complex;GO:0005886,plasma membrane;GO:0031982,vesicle;GO:0005938,cell cortex;GO:0005829,cytosol;GO:0005769,early endosome;GO:0019897,extrinsic component of plasma membrane;GO:0044354,macropinosome;GO:0045121,membrane raft;GO:0035749,myelin sheath adaxonal region;GO:0048471,perinuclear region of cytoplasm;GO:0032991,protein-containing complex;GO:0001726,ruffle;GO:0042383,sarcolemma;GO:0043220,Schmidt-Lanterman incisure	GO:0098641,cadherin binding involved in cell-cell adhesion;GO:0005262,calcium channel activity;GO:0005509,calcium ion binding;GO:0005544,calcium-dependent phospholipid binding;GO:0048306,calcium-dependent protein binding;GO:0008092,cytoskeletal protein binding;GO:0042802,identical protein binding;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding;GO:0001786,phosphatidylserine binding;GO:0019834,phospholipase A2 inhibitor activity;GO:0002020,protease binding;GO:0003723,RNA binding;GO:0044548,S100 protein binding;GO:0004867,serine-type endopeptidase inhibitor activity;GO:0046790,virion binding;GO:0004859,phospholipase inhibitor activity;GO:0044730,bone sialoprotein binding;GO:0031267,small GTPase binding	GO:0001525,angiogenesis;GO:0052362,catabolism by host of symbiont protein;GO:0035722,interleukin-12-mediated signaling pathway;GO:0001765,membrane raft assembly;GO:0052405,negative regulation by host of symbiont molecular function;GO:0044147,negative regulation of development of symbiont involved in interaction with host;GO:0032804,negative regulation of low-density lipoprotein particle receptor catabolic process;GO:0043312,neutrophil degranulation;GO:0036035,osteoclast development;GO:1905581,positive regulation of low-density lipoprotein particle clearance;GO:1905597,positive regulation of low-density lipoprotein particle receptor binding;GO:1905599,positive regulation of low-density lipoprotein receptor activity;GO:0001921,positive regulation of receptor recycling;GO:1905602,positive regulation of receptor-mediated endocytosis involved in cholesterol transport;GO:0044090,positive regulation of vacuole organization;GO:0031340,positive regulation of vesicle fusion;GO:0006900,vesicle budding from membrane;GO:0016032,viral process;GO:0007589,body fluid secretion;GO:0030199,collagen fibril organization;GO:0042730,fibrinolysis;GO:0048146,positive regulation of fibroblast proliferation;GO:0001934,positive regulation of protein phosphorylation;GO:0072659,protein localization to plasma membrane;GO:0097066,response to thyroid hormone	hsa:302,path:hsa05132,Salmonella infection
AUP1_HUMAN	Q9Y679	AUP1	Lipid droplet-regulating VLDL assembly factor AUP1	0.142372121	0.037105899	0.11680292	0.106186186	0.08973901	0.111494553	0.08973901	0.111494553	0.804873490097763	0.489070	0	1.2424312793288	0.489174	0	GO:0005776,autophagosome;GO:0031410,cytoplasmic vesicle;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0000839,Hrd1p ubiquitin ligase ERAD-L complex;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0005811,lipid droplet;GO:0016020,membrane	GO:0043130,ubiquitin binding;GO:0031624,ubiquitin conjugating enzyme binding;GO:0031625,ubiquitin protein ligase binding;GO:0097027,ubiquitin-protein transferase activator activity	GO:0071712,ER-associated misfolded protein catabolic process;GO:0140042,lipid droplet formation;GO:0034389,lipid droplet organization;GO:0061724,lipophagy;GO:1990044,protein localization to lipid droplet;GO:0009615,response to virus;GO:0030970,retrograde protein transport, ER to cytosol;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0016032,viral process	
CSCL1_HUMAN	O94886	TMEM63A	CSC1-like protein 1	0.35785493	0.340712712	0.447593638	0.423522424	0.349283821	0.435558031	0.349283821	0.435558031	0.801922582389486	0.486832	0	1.24700316708915	0.486938	0	GO:0034451,centriolar satellite;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005765,lysosomal membrane;GO:0005886,plasma membrane;GO:0035579,specific granule membrane;GO:0070821,tertiary granule membrane	GO:0005227,calcium activated cation channel activity;GO:0008381,mechanosensitive ion channel activity;GO:0003676,nucleic acid binding;GO:1990760,osmolarity-sensing cation channel activity	GO:0043312,neutrophil degranulation	
PRP6_HUMAN	O94906	PRPF6	Pre-mRNA-processing factor 6	3.910568609	2.014742273	4.429508396	4.833968288	2.962655441	4.631738342	2.962655441	4.631738342	0.639642229815753	0.352512	0	1.56337395091635	0.352758	0	GO:0071013,catalytic step 2 spliceosome;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0071005,U2-type precatalytic spliceosome;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005682,U5 snRNP	GO:0050681,androgen receptor binding;GO:0043021,ribonucleoprotein complex binding;GO:0003723,RNA binding;GO:0003713,transcription coactivator activity	GO:0000398,mRNA splicing, via spliceosome;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0006403,RNA localization;GO:0008380,RNA splicing;GO:0000375,RNA splicing, via transesterification reactions;GO:0000245,spliceosomal complex assembly;GO:0000244,spliceosomal tri-snRNP complex assembly	hsa:24148,path:hsa03040,Spliceosome
UBQL4_HUMAN	Q9NRR5	UBQLN4	Ubiquilin-4	0.034985162	0.040700596	0.090738291	2.55E-05	0.037842879	0.0453818955	0.037842879	0.0453818955	0.833876121370911	0.494126	0	1.19921889399588	0.494062	0	GO:0005776,autophagosome;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0032991,protein-containing complex;GO:0090734,site of DNA damage	GO:0042802,identical protein binding;GO:0036435,K48-linked polyubiquitin modification-dependent protein binding;GO:0031593,polyubiquitin modification-dependent protein binding	GO:0006914,autophagy;GO:0006974,cellular response to DNA damage stimulus;GO:0006281,DNA repair;GO:1901097,negative regulation of autophagosome maturation;GO:2000042,negative regulation of double-strand break repair via homologous recombination;GO:0032434,regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:56893,path:hsa04141,Protein processing in endoplasmic reticulum
RBM25_HUMAN	P49756	RBM25	RNA-binding protein 25	0.391399216	0.244170806	0.443917543	0.205175718	0.317785011	0.3245466305	0.317785011	0.3245466305	0.979165953781178	0.440342	0	1.02127733928898	0.440160	0	GO:0005737,cytoplasm;GO:0016607,nuclear speck	GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0003676,nucleic acid binding	GO:0006397,mRNA processing;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0042981,regulation of apoptotic process;GO:0008380,RNA splicing	hsa:58517,path:hsa03040,Spliceosome
ASPN_HUMAN	Q9BXN1	ASPN	Asporin	0.873017016	0.47972755	0.211099972	3.079688862	0.676372283	1.645394417	0.676372283	1.645394417	0.411070000002316	0.145886	0	2.43267569998873	0.146216	0	GO:0062023,collagen-containing extracellular matrix;GO:0031012,extracellular matrix;GO:0005615,extracellular space	GO:0005509,calcium ion binding;GO:0005518,collagen binding	GO:0030282,bone mineralization;GO:0070171,negative regulation of tooth mineralization;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway	
ATX10_HUMAN	Q9UBB4	ATXN10	Ataxin-10	2.668351302	1.778873769	2.516163113	2.387076829	2.2236125355	2.451619971	2.2236125355	2.451619971	0.906997235217089	0.465903	0	1.10253919325416	0.465778	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0005615,extracellular space;GO:0016020,membrane;GO:0043025,neuronal cell body;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane	GO:0019899,enzyme binding;GO:0042802,identical protein binding	GO:0060271,cilium assembly;GO:0007399,nervous system development;GO:0031175,neuron projection development	hsa:25814,path:hsa05017,Spinocerebellar ataxia
RMD1_HUMAN	Q96DB5	RMDN1	Regulator of microtubule dynamics protein 1	0.516810314	0.510079567	0.745240641	0.683990095	0.5134449405	0.714615368	0.5134449405	0.714615368	0.718491322033813	0.420388	0	1.39180525823099	0.420567	0	GO:0005737,cytoplasm;GO:0097431,mitotic spindle pole;GO:0005876,spindle microtubule	GO:0008017,microtubule binding	GO:0051315,attachment of mitotic spindle microtubules to kinetochore;GO:0007052,mitotic spindle organization	
LARP1_HUMAN	Q6PKG0	LARP1	La-related protein 1	0.439482089	0.039115408	0.278903547	2.55E-05	0.2392987485	0.1394645235	0.2392987485	0.1394645235	1.71583957335214	0.266671	0	0.582805068451915	0.266173	0	GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0016020,membrane	GO:0045296,cadherin binding;GO:0008190,eukaryotic initiation factor 4E binding;GO:0003730,mRNA 3'-UTR binding;GO:0048027,mRNA 5'-UTR binding;GO:0043024,ribosomal small subunit binding;GO:0000340,RNA 7-methylguanosine cap binding;GO:0003723,RNA binding;GO:0000339,RNA cap binding;GO:0008494,translation activator activity;GO:0031369,translation initiation factor binding	GO:0008283,cell population proliferation;GO:0072752,cellular response to rapamycin;GO:0048255,mRNA stabilization;GO:0017148,negative regulation of translation;GO:0045947,negative regulation of translational initiation;GO:0016239,positive regulation of macroautophagy;GO:0045948,positive regulation of translational initiation;GO:0045070,positive regulation of viral genome replication;GO:0010608,posttranscriptional regulation of gene expression;GO:1990928,response to amino acid starvation;GO:0031929,TOR signaling;GO:0038202,TORC1 signaling;GO:0006413,translational initiation	
SF3A3_HUMAN	Q12874	SF3A3	Splicing factor 3A subunit 3	2.670259767	1.781832687	2.172817094	2.279290504	2.226046227	2.226053799	2.226046227	2.226053799	0.999996598464959	0.433352	0	1.00000340154661	0.433155	0	GO:0071013,catalytic step 2 spliceosome;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0005686,U2 snRNP;GO:0071005,U2-type precatalytic spliceosome	GO:0003723,RNA binding;GO:0008270,zinc ion binding	GO:0000389,mRNA 3'-splice site recognition;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0000375,RNA splicing, via transesterification reactions;GO:1903241,U2-type prespliceosome assembly	hsa:10946,path:hsa03040,Spliceosome
KTAP2_HUMAN	Q8N6L1	KRTCAP2	Keratinocyte-associated protein 2	0.494230819	0.402451426	0.441275445	0.259706255	0.4483411225	0.35049085	0.4483411225	0.35049085	1.27918067618598	0.353690	0	0.78175039587184	0.353331	0	GO:0016021,integral component of membrane;GO:0008250,oligosaccharyltransferase complex	GO:0008047,enzyme activator activity	GO:0006487,protein N-linked glycosylation;GO:0042543,protein N-linked glycosylation via arginine	
MPPA_HUMAN	Q10713	PMPCA	Mitochondrial-processing peptidase subunit alpha	0.325564984	0.193562159	0.761646434	0.781962273	0.2595635715	0.7718043535	0.2595635715	0.7718043535	0.336307472642418	0.086755	0	2.97346946275934	0.087038	0	GO:0005615,extracellular space;GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0046872,metal ion binding	GO:0006851,mitochondrial calcium ion transmembrane transport;GO:0006627,protein processing involved in protein targeting to mitochondrion	
M3K5_HUMAN	Q99683	MAP3K5	Mitogen-activated protein kinase kinase kinase 5	0.028815695	0.024420409	0.040769139	0.063242683	0.026618052	0.052005911	0.026618052	0.052005911	0.511827434385295	0.236003	0	1.95378350752339	0.236328	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0009897,external side of plasma membrane;GO:1990604,IRE1-TRAF2-ASK1 complex;GO:1902911,protein kinase complex;GO:0032991,protein-containing complex	GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0000287,magnesium ion binding;GO:0004709,MAP kinase kinase kinase activity;GO:0019904,protein domain specific binding;GO:0042803,protein homodimerization activity;GO:0004672,protein kinase activity;GO:0019901,protein kinase binding;GO:0019903,protein phosphatase binding;GO:0106310,protein serine kinase activity;GO:0106311,protein threonine kinase activity	GO:0007257,activation of JUN kinase activity;GO:0000186,activation of MAPKK activity;GO:0097190,apoptotic signaling pathway;GO:0034198,cellular response to amino acid starvation;GO:0070301,cellular response to hydrogen peroxide;GO:1902170,cellular response to reactive nitrogen species;GO:0071356,cellular response to tumor necrosis factor;GO:0072577,endothelial cell apoptotic process;GO:0045087,innate immune response;GO:0070059,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0008631,intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0007254,JNK cascade;GO:0000165,MAPK cascade;GO:0038066,p38MAPK cascade;GO:0043065,positive regulation of apoptotic process;GO:0010666,positive regulation of cardiac muscle cell apoptotic process;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0046330,positive regulation of JNK cascade;GO:0043507,positive regulation of JUN kinase activity;GO:0045663,positive regulation of myoblast differentiation;GO:1901216,positive regulation of neuron death;GO:1900745,positive regulation of p38MAPK cascade;GO:0045893,positive regulation of transcription, DNA-templated;GO:1904707,positive regulation of vascular associated smooth muscle cell proliferation;GO:0097300,programmed necrotic cell death;GO:0006468,protein phosphorylation;GO:0034976,response to endoplasmic reticulum stress;GO:0002931,response to ischemia;GO:0051403,stress-activated MAPK cascade;GO:0016032,viral process;GO:0042060,wound healing	hsa:4217,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:4217,path:hsa04010,MAPK signaling pathway;hsa:4217,path:hsa04668,TNF signaling pathway;hsa:4217,path:hsa04071,Sphingolipid signaling pathway;hsa:4217,path:hsa04210,Apoptosis;hsa:4217,path:hsa04530,Tight junction;hsa:4217,path:hsa04722,Neurotrophin signaling pathway;hsa:4217,path:hsa04714,Thermogenesis;hsa:4217,path:hsa05014,Amyotrophic lateral sclerosis (ALS);hsa:4217,path:hsa05017,Spinocerebellar ataxia;hsa:4217,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:4217,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4217,path:hsa01524,Platinum drug resistance
G3P_HUMAN	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	229.129279	262.4228574	205.4060507	96.6652212	245.7760682	151.03563595	245.7760682	151.03563595	1.62727204513088	0.281550	0	0.614525397269741	0.281072	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0097452,GAIT complex;GO:0043231,intracellular membrane-bounded organelle;GO:0005811,lipid droplet;GO:0016020,membrane;GO:0015630,microtubule cytoskeleton;GO:0031965,nuclear membrane;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:1990904,ribonucleoprotein complex;GO:0031982,vesicle	GO:0019828,aspartic-type endopeptidase inhibitor activity;GO:0097718,disordered domain specific binding;GO:0004365,glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity;GO:0042802,identical protein binding;GO:0008017,microtubule binding;GO:0051287,NAD binding;GO:0050661,NADP binding;GO:0035605,peptidyl-cysteine S-nitrosylase activity;GO:0016620,oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0061621,canonical glycolysis;GO:0071346,cellular response to interferon-gamma;GO:0050832,defense response to fungus;GO:0006094,gluconeogenesis;GO:0006096,glycolytic process;GO:0051873,killing by host of symbiont cells;GO:0031640,killing of cells of other organism;GO:0000226,microtubule cytoskeleton organization;GO:0010951,negative regulation of endopeptidase activity;GO:0017148,negative regulation of translation;GO:0051402,neuron apoptotic process;GO:0035606,peptidyl-cysteine S-trans-nitrosylation;GO:0001819,positive regulation of cytokine production;GO:0050821,protein stabilization;GO:0016241,regulation of macroautophagy	hsa:2597,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:2597,path:hsa04066,HIF-1 signaling pathway;hsa:2597,path:hsa05010,Alzheimer disease;hsa:2597,path:hsa05130,Pathogenic Escherichia coli infection;hsa:2597,path:hsa05132,Salmonella infection
UB2V1_HUMAN	Q13404	UBE2V1	Ubiquitin-conjugating enzyme E2 variant 1	1.833195185	2.963221039	0.319682908	0.218213657	2.398208112	0.2689482825	2.398208112	0.2689482825	8.9169861569947	0.022110	1	0.112145514459005	0.021868	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0035370,UBC13-UEV1A complex;GO:0031371,ubiquitin conjugating enzyme complex;GO:0000151,ubiquitin ligase complex		GO:0000187,activation of MAPK activity;GO:0035973,aggrephagy;GO:0030154,cell differentiation;GO:0070498,interleukin-1-mediated signaling pathway;GO:0007254,JNK cascade;GO:0070423,nucleotide-binding oligomerization domain containing signaling pathway;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0045893,positive regulation of transcription, DNA-templated;GO:0006301,postreplication repair;GO:0070534,protein K63-linked ubiquitination;GO:0000209,protein polyubiquitination;GO:0006282,regulation of DNA repair;GO:0006355,regulation of transcription, DNA-templated	hsa:7335,path:hsa05131,Shigellosis
ECH1_HUMAN	Q13011	ECH1	Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial	3.308478627	4.513139961	3.753156238	2.359083362	3.910809294	3.0561198	3.910809294	3.0561198	1.27966491824044	0.353571	0	0.781454571228704	0.353212	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005782,peroxisomal matrix;GO:0005777,peroxisome	GO:0051750,delta3,5-delta2,4-dienoyl-CoA isomerase activity;GO:0003824,catalytic activity	GO:0006635,fatty acid beta-oxidation;GO:0008104,protein localization	hsa:1891,path:hsa04146,Peroxisome
SYEP_HUMAN	P07814	EPRS1	Bifunctional glutamate/proline--tRNA ligase	10.3925622	6.276542932	9.720360387	7.487528907	8.334552566	8.603944647	8.334552566	8.603944647	0.96868970082299	0.443921	0	1.03232232070849	0.443747	0	GO:0017101,aminoacyl-tRNA synthetase multienzyme complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0097452,GAIT complex;GO:0016020,membrane;GO:0005886,plasma membrane;GO:1990904,ribonucleoprotein complex	GO:0005524,ATP binding;GO:0004818,glutamate-tRNA ligase activity;GO:0051020,GTPase binding;GO:0042802,identical protein binding;GO:0004827,proline-tRNA ligase activity;GO:0042803,protein homodimerization activity;GO:0035613,RNA stem-loop binding;GO:0008270,zinc ion binding	GO:0032869,cellular response to insulin stimulus;GO:0071346,cellular response to interferon-gamma;GO:0006424,glutamyl-tRNA aminoacylation;GO:0017148,negative regulation of translation;GO:0006433,prolyl-tRNA aminoacylation;GO:0065003,protein-containing complex assembly;GO:0140212,regulation of long-chain fatty acid import into cell;GO:0006418,tRNA aminoacylation for protein translation	hsa:2058,path:hsa00860,Porphyrin and chlorophyll metabolism;hsa:2058,path:hsa00970,Aminoacyl-tRNA biosynthesis
B3AT_HUMAN	P02730	SLC4A1	Band 3 anion transport protein	1.735495422	1.863044452	8.973471503	124.1948272	1.799269937	66.5841493515	1.799269937	66.5841493515	0.0270224964127963	0.000000	-1	37.0062034507833	0.000000	1	GO:0016323,basolateral plasma membrane;GO:0072562,blood microparticle;GO:0030863,cortical cytoskeleton;GO:0009898,cytoplasmic side of plasma membrane;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane;GO:0030018,Z disc	GO:0008509,anion transmembrane transporter activity;GO:0015301,anion;GO:0030506,ankyrin binding;GO:0015106,bicarbonate transmembrane transporter activity;GO:0015108,chloride transmembrane transporter activity;GO:0030492,hemoglobin binding;GO:0005452,inorganic anion exchanger activity;GO:0042803,protein homodimerization activity;GO:0043495,protein-membrane adaptor activity;GO:0022857,transmembrane transporter activity	GO:0006820,anion transport;GO:0015701,bicarbonate transport;GO:0007596,blood coagulation;GO:0006873,cellular ion homeostasis;GO:0006821,chloride transport;GO:0048821,erythrocyte development;GO:0050801,ion homeostasis;GO:1904539,negative regulation of glycolytic process through fructose-6-phosphate;GO:0051354,negative regulation of oxidoreductase activity;GO:0035811,negative regulation of urine volume;GO:0045852,pH elevation;GO:0017121,plasma membrane phospholipid scrambling;GO:0072659,protein localization to plasma membrane;GO:0051453,regulation of intracellular pH;GO:0055085,transmembrane transport	hsa:6521,path:hsa04966,Collecting duct acid secretion
GDE_HUMAN	P35573	AGL	Glycogen debranching enzyme	0.989941737	0.874972876	2.241044953	1.472250501	0.9324573065	1.856647727	0.9324573065	1.856647727	0.502226293625813	0.227182	0	1.991134300796	0.227510	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016234,inclusion body;GO:0043033,isoamylase complex;GO:0005634,nucleus;GO:0016529,sarcoplasmic reticulum;GO:0034774,secretory granule lumen	GO:0004134,4-alpha-glucanotransferase activity;GO:0004135,amylo-alpha-1,6-glucosidase activity;GO:0102500,beta-maltose 4-alpha-glucanotransferase activity;GO:0004133,glycogen debranching enzyme activity;GO:0030247,polysaccharide binding;GO:0031593,polyubiquitin modification-dependent protein binding	GO:0005978,glycogen biosynthetic process;GO:0005980,glycogen catabolic process;GO:0043312,neutrophil degranulation;GO:0051384,response to glucocorticoid;GO:0007584,response to nutrient	hsa:178,path:hsa00500,Starch and sucrose metabolism
DERM_HUMAN	Q07507	DPT	Dermatopontin	1.553740641	4.353261118	1.831724661	3.614333705	2.9535008795	2.723029183	2.9535008795	2.723029183	1.08463798255959	0.406589	0	0.921966606443328	0.406336	0	GO:0062023,collagen-containing extracellular matrix;GO:0005615,extracellular space	GO:0005201,extracellular matrix structural constituent	GO:0007155,cell adhesion;GO:0030199,collagen fibril organization;GO:0008285,negative regulation of cell population proliferation	
CTL1_HUMAN	Q8WWI5	SLC44A1	Choline transporter-like protein 1	0.23321487	0.266719039	0.483928786	0.715857893	0.2499669545	0.5998933395	0.2499669545	0.5998933395	0.416685664002109	0.150684	0	2.39989058033669	0.151015	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0015220,choline transmembrane transporter activity;GO:0022857,transmembrane transporter activity	GO:0042426,choline catabolic process;GO:0015871,choline transport;GO:0006656,phosphatidylcholine biosynthetic process;GO:0055085,transmembrane transport;GO:0150104,transport across blood-brain barrier	hsa:23446,path:hsa05231,Choline metabolism in cancer
CAVN3_HUMAN	Q969G5	CAVIN3	Caveolae-associated protein 3	0.437568129	1.748305505	0.813132611	2.261983592	1.092936817	1.5375581015	1.092936817	1.5375581015	0.710826352470037	0.413991	0	1.40681334692379	0.414177	0	GO:0005901,caveola;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0032991,protein-containing complex	GO:0005080,protein kinase C binding	GO:0032922,circadian regulation of gene expression;GO:0030866,cortical actin cytoskeleton organization;GO:1901003,negative regulation of fermentation;GO:0051898,negative regulation of protein kinase B signaling;GO:0070374,positive regulation of ERK1 and ERK2 cascade	
NFM_HUMAN	P07197	NEFM	Neurofilament medium polypeptide	0.440768352	0.405106219	0.389525896	0.646568275	0.4229372855	0.5180470855	0.4229372855	0.5180470855	0.816407035842691	0.497743	0	1.22487920375136	0.497837	0	GO:0030424,axon;GO:0045111,intermediate filament cytoskeleton;GO:0097418,neurofibrillary tangle;GO:0005883,neurofilament	GO:0008017,microtubule binding;GO:0005200,structural constituent of cytoskeleton;GO:0005198,structural molecule activity	GO:0033693,neurofilament bundle assembly	hsa:4741,path:hsa05014,Amyotrophic lateral sclerosis (ALS)
FARP1_HUMAN	Q9Y4F1	FARP1	FERM, ARHGEF and pleckstrin domain-containing protein 1	0.443021614	0.562264603	0.446655543	0.686581942	0.5026431085	0.5666187425	0.5026431085	0.5666187425	0.887092273514055	0.473343	0	1.12727844651231	0.473234	0	GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0030425,dendrite;GO:0043197,dendritic spine;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0030175,filopodium;GO:0098890,extrinsic component of postsynaptic membrane;GO:0098978,glutamatergic synapse	GO:0008092,cytoskeletal protein binding;GO:0005085,guanyl-nucleotide exchange factor activity;GO:0031267,small GTPase binding	GO:0048813,dendrite morphogenesis;GO:0010923,negative regulation of phosphatase activity;GO:0007416,synapse assembly;GO:0098974,postsynaptic actin cytoskeleton organization;GO:1905606,regulation of presynapse assembly;GO:0098942,retrograde trans-synaptic signaling by trans-synaptic protein complex	
RL17_HUMAN	P18621	RPL17	60S ribosomal protein L17	1.62854667	2.799486242	0.08523061	0.12011247	2.214016456	0.10267154	2.214016456	0.10267154	21.5640717573731	0.002923	1	0.0463734312912442	0.002867	-1	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0005634,nucleus;GO:0015934,large ribosomal subunit	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6139,path:hsa03010,Ribosome;hsa:100526842,path:hsa03010,Ribosome
FERM1_HUMAN	Q9BQL6	FERMT1	Fermitin family homolog 1	0.104133633	0.038646516	0.174355705	0.315527574	0.0713900745	0.2449416395	0.0713900745	0.2449416395	0.291457486141306	0.057082	0	3.43103213178465	0.057317	0	GO:0030054,cell junction;GO:0071944,cell periphery;GO:0030055,cell-substrate junction;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0032587,ruffle membrane	GO:0051015,actin filament binding;GO:0005178,integrin binding	GO:0071711,basement membrane organization;GO:0007155,cell adhesion;GO:0007160,cell-matrix adhesion;GO:0090162,establishment of epithelial cell polarity;GO:0007229,integrin-mediated signaling pathway;GO:0051546,keratinocyte migration;GO:0043616,keratinocyte proliferation;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010629,negative regulation of gene expression;GO:0042308,negative regulation of protein import into nucleus;GO:2000647,negative regulation of stem cell proliferation;GO:0051886,negative regulation of timing of anagen;GO:0033630,positive regulation of cell adhesion mediated by integrin;GO:0001954,positive regulation of cell-matrix adhesion;GO:0033625,positive regulation of integrin activation;GO:0071636,positive regulation of transforming growth factor beta production;GO:0030511,positive regulation of transforming growth factor beta receptor signaling pathway;GO:1903691,positive regulation of wound healing, spreading of epidermal cells	
QRIC1_HUMAN	Q2TAL8	QRICH1	Transcriptional regulator QRICH1	0.041520538	0.090327526	0.119126326	0.026814047	0.065924032	0.0729701865	0.065924032	0.0729701865	0.903437899257664	0.467221	0	1.10688294217198	0.467098	0	GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003677,DNA binding	GO:0030968,endoplasmic reticulum unfolded protein response;GO:0140467,integrated stress response signaling;GO:0070059,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0036499,PERK-mediated unfolded protein response;GO:0043065,positive regulation of apoptotic process;GO:0045893,positive regulation of transcription, DNA-templated;GO:0034976,response to endoplasmic reticulum stress;GO:0042981,regulation of apoptotic process	
UBE4A_HUMAN	Q14139	UBE4A	Ubiquitin conjugation factor E4 A	0.73831888	0.653446148	0.957258769	1.180188655	0.695882514	1.068723712	0.695882514	1.068723712	0.651134157674608	0.362669	0	1.53578181733131	0.362905	0	GO:0005737,cytoplasm;GO:0005634,nucleus;GO:0000151,ubiquitin ligase complex	GO:0034450,ubiquitin-ubiquitin ligase activity	GO:0000209,protein polyubiquitination;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:9354,path:hsa04120,Ubiquitin mediated proteolysis
COX41_HUMAN	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	9.251988867	35.93056365	1.419463809	0.705133195	22.5912762585	1.062298502	22.5912762585	1.062298502	21.2664107272741	0.003029	1	0.0470225094786448	0.002972	-1	GO:0005829,cytosol;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005751,mitochondrial respiratory chain complex IV;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0004129,cytochrome-c oxidase activity	GO:0006091,generation of precursor metabolites and energy;GO:0006123,mitochondrial electron transport, cytochrome c to oxygen;GO:0007584,response to nutrient;GO:0006119,oxidative phosphorylation	hsa:1327,path:hsa00190,Oxidative phosphorylation;hsa:1327,path:hsa04260,Cardiac muscle contraction;hsa:1327,path:hsa04714,Thermogenesis;hsa:1327,path:hsa05010,Alzheimer disease;hsa:1327,path:hsa05012,Parkinson disease;hsa:1327,path:hsa05016,Huntington disease;hsa:1327,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
SYNC_HUMAN	O43776	NARS1	Asparagine--tRNA ligase, cytoplasmic	2.86381779	2.257813617	5.014238162	2.689319488	2.5608157035	3.851778825	2.5608157035	3.851778825	0.664839758419929	0.374673	0	1.50412183888734	0.374898	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0004816,asparagine-tRNA ligase activity;GO:0005524,ATP binding;GO:0031728,CCR3 chemokine receptor binding;GO:0003676,nucleic acid binding;GO:0046983,protein dimerization activity	GO:0006421,asparaginyl-tRNA aminoacylation;GO:0016477,cell migration;GO:0006418,tRNA aminoacylation for protein translation	hsa:4677,path:hsa00970,Aminoacyl-tRNA biosynthesis
SFPQ_HUMAN	P23246	SFPQ	Splicing factor, proline- and glutamine-rich	17.31599115	16.73423335	16.84311309	17.57966273	17.02511225	17.21138791	17.02511225	17.21138791	0.989177185420836	0.436962	0	1.01094122947706	0.436773	0	GO:0000785,chromatin;GO:0005829,cytosol;GO:0032839,dendrite cytoplasm;GO:0016363,nuclear matrix;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0042382,paraspeckles;GO:0090575,RNA polymerase II transcription regulator complex	GO:0003682,chromatin binding;GO:0003677,DNA binding;GO:0042826,histone deacetylase binding;GO:0003676,nucleic acid binding;GO:0042803,protein homodimerization activity;GO:0003723,RNA binding;GO:0000976,transcription regulatory region sequence-specific DNA binding	GO:0002218,activation of innate immune response;GO:0000380,alternative mRNA splicing, via spliceosome;GO:0098963,dendritic transport of messenger ribonucleoprotein complex;GO:0000724,double-strand break repair via homologous recombination;GO:0070932,histone H3 deacetylation;GO:0045087,innate immune response;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0033668,negative regulation by symbiont of host apoptotic process;GO:0042754,negative regulation of circadian rhythm;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:1902177,positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:0045876,positive regulation of sister chromatid cohesion;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0042752,regulation of circadian rhythm;GO:0006355,regulation of transcription, DNA-templated;GO:0048511,rhythmic process;GO:0008380,RNA splicing	
ATRAP_HUMAN	Q6RW13	AGTRAP	Type-1 angiotensin II receptor-associated protein	0.647835636	1.307635442	0.113379483	0.319482304	0.977735539	0.2164308935	0.977735539	0.2164308935	4.51754148027855	0.075095	0	0.221359339889966	0.074623	0	GO:0005938,cell cortex;GO:0030659,cytoplasmic vesicle membrane;GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005886,plasma membrane	GO:0004945,angiotensin type II receptor activity;GO:0042802,identical protein binding	GO:0008217,regulation of blood pressure;GO:0001666,response to hypoxia	
CAP1_HUMAN	Q01518	CAP1	Adenylyl cyclase-associated protein 1	17.7043375	36.90385385	22.1382353	24.67484725	27.304095675	23.406541275	27.304095675	23.406541275	1.16651560579618	0.382979	0	0.857253855011625	0.382677	0	GO:0035578,azurophil granule lumen;GO:0030864,cortical actin cytoskeleton;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005925,focal adhesion;GO:0005886,plasma membrane	GO:0003779,actin binding;GO:0008179,adenylate cyclase binding	GO:0030036,actin cytoskeleton organization;GO:0007190,activation of adenylate cyclase activity;GO:0001667,ameboidal-type cell migration;GO:0019933,cAMP-mediated signaling;GO:0000902,cell morphogenesis;GO:0007163,establishment or maintenance of cell polarity;GO:0043312,neutrophil degranulation;GO:0006898,receptor-mediated endocytosis;GO:0045761,regulation of adenylate cyclase activity;GO:0007165,signal transduction	
RM39_HUMAN	Q9NYK5	MRPL39	39S ribosomal protein L39, mitochondrial	0.155384177	0.081370701	0.137180279	0.032063824	0.118377439	0.0846220515	0.118377439	0.0846220515	1.39889587763067	0.326073	0	0.714849486649225	0.325665	0	GO:0005743,mitochondrial inner membrane;GO:0005762,mitochondrial large ribosomal subunit;GO:0005761,mitochondrial ribosome;GO:0005739,mitochondrion	GO:0000166,nucleotide binding;GO:0003723,RNA binding	GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination	
IGLC2_HUMAN	P0DOY2	IGLC2	Immunoglobulin lambda constant 2	34.75518664	5.150228544	14.95131023	12.71232809	19.952707592	13.83181916	19.952707592	13.83181916	1.44252230029878	0.316799	0	0.693230184235539	0.316376	0	GO:0072562,blood microparticle;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0042571,immunoglobulin complex, circulating;GO:0005886,plasma membrane	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0045087,innate immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response	
IRF6_HUMAN	O14896	IRF6	Interferon regulatory factor 6	2.55E-05	2.55E-05	2.55E-05	2.55E-05	2.55e-005	2.55e-005	2.55e-005	2.55e-005	1	0.433351	0	1	0.433154	0	GO:0030054,cell junction;GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0001228,DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700,DNA-binding transcription factor activity;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565,sequence-specific DNA binding;GO:1990837,sequence-specific double-stranded DNA binding;GO:0000976,transcription regulatory region sequence-specific DNA binding	GO:0007050,cell cycle arrest;GO:0048468,cell development;GO:1904888,cranial skeletal system development;GO:0002376,immune system process;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0030216,keratinocyte differentiation;GO:0043616,keratinocyte proliferation;GO:0060173,limb development;GO:0060644,mammary gland epithelial cell differentiation;GO:0008285,negative regulation of cell population proliferation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0006357,regulation of transcription by RNA polymerase II;GO:0060021,roof of mouth development;GO:0060337,type I interferon signaling pathway	
MXRA5_HUMAN	Q9NR99	MXRA5	Matrix-remodeling-associated protein 5	1.245856247	0.934689023	0.498270144	0.19320083	1.090272635	0.345735487	1.090272635	0.345735487	3.1534877847237	0.128002	0	0.317109203607591	0.127446	0	GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region	GO:0005201,extracellular matrix structural constituent	GO:0071559,response to transforming growth factor beta	
TRIPC_HUMAN	Q14669	TRIP12	E3 ubiquitin-protein ligase TRIP12	0.136201986	0.045256974	0.314072654	0.054493527	0.09072948	0.1842830905	0.09072948	0.1842830905	0.492337521331074	0.218123	0	2.03112693360526	0.218453	0	GO:0005829,cytosol;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0046966,thyroid hormone receptor binding;GO:0061630,ubiquitin protein ligase activity;GO:0004842,ubiquitin-protein transferase activity;GO:0008270,zinc ion binding	GO:0006974,cellular response to DNA damage stimulus;GO:0006281,DNA repair;GO:2000780,negative regulation of double-strand break repair;GO:1901315,negative regulation of histone H2A K63-linked ubiquitination;GO:0000209,protein polyubiquitination;GO:2000779,regulation of double-strand break repair;GO:0045995,regulation of embryonic development;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:9320,path:hsa04120,Ubiquitin mediated proteolysis
VISL1_HUMAN	P62760	VSNL1	Visinin-like protein 1	1.364509115	1.657337679	0.148353957	0.052783132	1.510923397	0.1005685445	1.510923397	0.1005685445	15.0238168854079	0.007109	1	0.0665609816484958	0.006999	-1	GO:0005829,cytosol;GO:0016020,membrane	GO:0005509,calcium ion binding	GO:0046676,negative regulation of insulin secretion;GO:0045921,positive regulation of exocytosis;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus	
SUCB2_HUMAN	Q96I99	SUCLG2	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial	5.570429032	6.321084449	7.661471377	14.27153888	5.9457567405	10.9665051285	5.9457567405	10.9665051285	0.542174254316267	0.263957	0	1.84442546291892	0.264268	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005886,plasma membrane;GO:0042709,succinate-CoA ligase complex;GO:0045244,succinate-CoA ligase complex (GDP-forming)	GO:0005524,ATP binding;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0000287,magnesium ion binding;GO:0044877,protein-containing complex binding;GO:0004775,succinate-CoA ligase (ADP-forming) activity;GO:0004776,succinate-CoA ligase (GDP-forming) activity;GO:0016874,ligase activity;GO:0046872,metal ion binding	GO:0006105,succinate metabolic process;GO:0006104,succinyl-CoA metabolic process;GO:0006099,tricarboxylic acid cycle	hsa:8801,path:hsa00020,Citrate cycle (TCA cycle);hsa:8801,path:hsa00640,Propanoate metabolism
TXD17_HUMAN	Q9BRA2	TXNDC17	Thioredoxin domain-containing protein 17	2.004317167	8.764262639	1.738377832	0.337825201	5.384289903	1.0381015165	5.384289903	1.0381015165	5.18666991370299	0.059940	0	0.192801935854456	0.059513	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0004601,peroxidase activity;GO:0047134,protein-disulfide reductase activity	GO:0033209,tumor necrosis factor-mediated signaling pathway	
VP13C_HUMAN	Q709C8	VPS13C	Vacuolar protein sorting-associated protein 13C	0.838801126	2.015371778	2.390824138	2.306869313	1.427086452	2.3488467255	1.427086452	2.3488467255	0.607568998226658	0.323777	0	1.64590359764694	0.324047	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0032127,dense core granule membrane;GO:0070062,extracellular exosome;GO:0019898,extrinsic component of membrane;GO:0005741,mitochondrial outer membrane		GO:0006895,Golgi to endosome transport;GO:0007005,mitochondrion organization;GO:1905090,negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization;GO:0045053,protein retention in Golgi apparatus;GO:0006623,protein targeting to vacuole;GO:0032868,response to insulin	
CSK22_HUMAN	P19784	CSNK2A2	Casein kinase II subunit alpha'	0.173327964	0.135788763	0.368383449	0.170916514	0.1545583635	0.2696499815	0.1545583635	0.2696499815	0.573181435578923	0.292463	0	1.74464827003684	0.292757	0	GO:0001669,acrosomal vesicle;GO:0000785,chromatin;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0005956,protein kinase CK2 complex	GO:0005524,ATP binding;GO:0047485,protein N-terminus binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0004672,protein kinase activity	GO:0006915,apoptotic process;GO:0021987,cerebral cortex development;GO:0097421,liver regeneration;GO:0016236,macroautophagy;GO:0007076,mitotic chromosome condensation;GO:2001234,negative regulation of apoptotic signaling pathway;GO:2000059,negative regulation of ubiquitin-dependent protein catabolic process;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:0006656,phosphatidylcholine biosynthetic process;GO:1903955,positive regulation of protein targeting to mitochondrion;GO:0006457,protein folding;GO:1903146,regulation of autophagy of mitochondrion;GO:0051726,regulation of cell cycle;GO:1905818,regulation of chromosome separation;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0007283,spermatogenesis;GO:0016055,Wnt signaling pathway	hsa:1459,path:hsa03008,Ribosome biogenesis in eukaryotes;hsa:1459,path:hsa04310,Wnt signaling pathway;hsa:1459,path:hsa04064,NF-kappa B signaling pathway;hsa:1459,path:hsa04137,Mitophagy - animal;hsa:1459,path:hsa04520,Adherens junction;hsa:1459,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:1459,path:hsa05162,Measles
CUL4A_HUMAN	Q13619	CUL4A	Cullin-4A	0.026431786	0.029082649	0.071181784	0.062834058	0.0277572175	0.067007921	0.0277572175	0.067007921	0.414237855551436	0.148588	0	2.41407197965718	0.148918	0	GO:0080008,Cul4-RING E3 ubiquitin ligase complex;GO:0031464,Cul4A-RING E3 ubiquitin ligase complex;GO:0031461,cullin-RING ubiquitin ligase complex;GO:0005654,nucleoplasm;GO:0019005,SCF ubiquitin ligase complex	GO:0031625,ubiquitin protein ligase binding;GO:0004842,ubiquitin-protein transferase activity	GO:0006974,cellular response to DNA damage stimulus;GO:0042769,DNA damage response, detection of DNA damage;GO:0000082,G1/S transition of mitotic cell cycle;GO:0070911,global genome nucleotide-excision repair;GO:0030097,hemopoiesis;GO:0001701,in utero embryonic development;GO:0097193,intrinsic apoptotic signaling pathway;GO:0030853,negative regulation of granulocyte differentiation;GO:0000715,nucleotide-excision repair, DNA damage recognition;GO:0000717,nucleotide-excision repair, DNA duplex unwinding;GO:0033683,nucleotide-excision repair, DNA incision;GO:0006295,nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006294,nucleotide-excision repair, preincision complex assembly;GO:0006293,nucleotide-excision repair, preincision complex stabilization;GO:0008284,positive regulation of cell population proliferation;GO:1900087,positive regulation of G1/S transition of mitotic cell cycle;GO:0043687,post-translational protein modification;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567,protein ubiquitination;GO:2000001,regulation of DNA damage checkpoint;GO:2000819,regulation of nucleotide-excision repair;GO:0051246,regulation of protein metabolic process;GO:0048511,rhythmic process;GO:0042254,ribosome biogenesis;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0035019,somatic stem cell population maintenance;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0016032,viral process;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:8451,path:hsa04120,Ubiquitin mediated proteolysis;hsa:8451,path:hsa03420,Nucleotide excision repair;hsa:8451,path:hsa05170,Human immunodeficiency virus 1 infection
SYRC_HUMAN	P54136	RARS1	Arginine--tRNA ligase, cytoplasmic	6.468379719	3.875932267	7.09032013	7.528155606	5.172155993	7.309237868	5.172155993	7.309237868	0.707619055010347	0.411300	0	1.41318975643664	0.411489	0	GO:0017101,aminoacyl-tRNA synthetase multienzyme complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0034618,arginine binding;GO:0004814,arginine-tRNA ligase activity;GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0000049,tRNA binding	GO:0006420,arginyl-tRNA aminoacylation;GO:0006418,tRNA aminoacylation for protein translation	hsa:5917,path:hsa00970,Aminoacyl-tRNA biosynthesis
KCRB_HUMAN	P12277	CKB	Creatine kinase B-type	0.191285798	0.702855087	1.485498431	2.255880847	0.4470704425	1.870689639	0.4470704425	1.870689639	0.238986966720459	0.029845	-1	4.18432860052026	0.030007	1	GO:0005829,cytosol;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0043025,neuronal cell body;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0004111,creatine kinase activity;GO:0016301,kinase activity;GO:0031625,ubiquitin protein ligase binding	GO:0030644,cellular chloride ion homeostasis;GO:0021549,cerebellum development;GO:0006600,creatine metabolic process;GO:0046314,phosphocreatine biosynthetic process;GO:0021762,substantia nigra development	hsa:1152,path:hsa00330,Arginine and proline metabolism
PP4C_HUMAN	P60510	PPP4C	Serine/threonine-protein phosphatase 4 catalytic subunit	0.10699949	0.05003293	0.12764065	2.55E-05	0.07851621	0.063833075	0.07851621	0.063833075	1.23002393351722	0.366044	0	0.812992310759778	0.365709	0	GO:0005829,cytosol;GO:0005815,microtubule organizing center;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0030289,protein phosphatase 4 complex	GO:0046872,metal ion binding;GO:0004704,NF-kappaB-inducing kinase activity;GO:0106306,protein serine phosphatase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0106307,protein threonine phosphatase activity	GO:0010569,regulation of double-strand break repair via homologous recombination	hsa:5531,path:hsa04922,Glucagon signaling pathway
FKB15_HUMAN	Q5T1M5	FKBP15	FK506-binding protein 15	0.710462628	0.389330503	0.609565817	0.65059942	0.5498965655	0.6300826185	0.5498965655	0.6300826185	0.872737240092586	0.478819	0	1.1458202469897	0.478722	0	GO:0015629,actin cytoskeleton;GO:0005769,early endosome;GO:0030426,growth cone;GO:0016020,membrane	GO:0003779,actin binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity	GO:0006897,endocytosis;GO:0010923,negative regulation of phosphatase activity	
MK03_HUMAN	P27361	MAPK3	Mitogen-activated protein kinase 3	1.174121897	1.325522431	4.087293572	5.382659601	1.249822164	4.7349765865	1.249822164	4.7349765865	0.263955299708006	0.041707	-1	3.7885202574308	0.041905	1	GO:0005901,caveola;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005769,early endosome;GO:0005788,endoplasmic reticulum lumen;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0005770,late endosome;GO:0005739,mitochondrion;GO:0005635,nuclear envelope;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0031143,pseudopodium	GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0004707,MAP kinase activity;GO:0004708,MAP kinase kinase activity;GO:0019902,phosphatase binding;GO:0001784,phosphotyrosine residue binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0097110,scaffold protein binding	GO:0000187,activation of MAPK activity;GO:0000186,activation of MAPKK activity;GO:0007568,aging;GO:0006915,apoptotic process;GO:0019369,arachidonic acid metabolic process;GO:0007411,axon guidance;GO:0060020,Bergmann glial cell differentiation;GO:0030509,BMP signaling pathway;GO:0061308,cardiac neural crest cell development involved in heart development;GO:0051216,cartilage development;GO:0072584,caveolin-mediated endocytosis;GO:0007049,cell cycle;GO:0007166,cell surface receptor signaling pathway;GO:0034198,cellular response to amino acid starvation;GO:0071276,cellular response to cadmium ion;GO:1903351,cellular response to dopamine;GO:0071260,cellular response to mechanical stimulus;GO:0034614,cellular response to reactive oxygen species;GO:0071356,cellular response to tumor necrosis factor;GO:0046697,decidualization;GO:0006975,DNA damage induced protein phosphorylation;GO:0070371,ERK1 and ERK2 cascade;GO:0060324,face development;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0035556,intracellular signal transduction;GO:0031663,lipopolysaccharide-mediated signaling pathway;GO:0060425,lung morphogenesis;GO:0000165,MAPK cascade;GO:0033668,negative regulation by symbiont of host apoptotic process;GO:2000657,negative regulation of apolipoprotein binding;GO:0042473,outer ear morphogenesis;GO:0018105,peptidyl-serine phosphorylation;GO:0038083,peptidyl-tyrosine autophosphorylation;GO:0016310,phosphorylation;GO:0030168,platelet activation;GO:0031281,positive regulation of cyclase activity;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0010628,positive regulation of gene expression;GO:0035066,positive regulation of histone acetylation;GO:0033129,positive regulation of histone phosphorylation;GO:0010759,positive regulation of macrophage chemotaxis;GO:0120041,positive regulation of macrophage proliferation;GO:0001934,positive regulation of protein phosphorylation;GO:0051973,positive regulation of telomerase activity;GO:1904355,positive regulation of telomere capping;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045727,positive regulation of translation;GO:1904417,positive regulation of xenophagy;GO:0006468,protein phosphorylation;GO:0065003,protein-containing complex assembly;GO:0030641,regulation of cellular pH;GO:1900034,regulation of cellular response to heat;GO:0051493,regulation of cytoskeleton organization;GO:0051090,regulation of DNA-binding transcription factor activity;GO:2000641,regulation of early endosome to late endosome transport;GO:0090170,regulation of Golgi inheritance;GO:0030278,regulation of ossification;GO:0014066,regulation of phosphatidylinositol 3-kinase signaling;GO:0032872,regulation of stress-activated MAPK cascade;GO:0070849,response to epidermal growth factor;GO:0043330,response to exogenous dsRNA;GO:0009636,response to toxic substance;GO:0019233,sensory perception of pain;GO:0051403,stress-activated MAPK cascade;GO:0048538,thymus development;GO:0030878,thyroid gland development;GO:0060440,trachea formation;GO:0006361,transcription initiation from RNA polymerase I promoter;GO:0016032,viral process	hsa:5595,path:hsa04014,Ras signaling pathway;hsa:5595,path:hsa04015,Rap1 signaling pathway;hsa:5595,path:hsa04010,MAPK signaling pathway;hsa:5595,path:hsa04012,ErbB signaling pathway;hsa:5595,path:hsa04350,TGF-beta signaling pathway;hsa:5595,path:hsa04370,VEGF signaling pathway;hsa:5595,path:hsa04371,Apelin signaling pathway;hsa:5595,path:hsa04668,TNF signaling pathway;hsa:5595,path:hsa04066,HIF-1 signaling pathway;hsa:5595,path:hsa04068,FoxO signaling pathway;hsa:5595,path:hsa04072,Phospholipase D signaling pathway;hsa:5595,path:hsa04071,Sphingolipid signaling pathway;hsa:5595,path:hsa04024,cAMP signaling pathway;hsa:5595,path:hsa04022,cGMP-PKG signaling pathway;hsa:5595,path:hsa04151,PI3K-Akt signaling pathway;hsa:5595,path:hsa04150,mTOR signaling pathway;hsa:5595,path:hsa04140,Autophagy - animal;hsa:5595,path:hsa04114,Oocyte meiosis;hsa:5595,path:hsa04210,Apoptosis;hsa:5595,path:hsa04218,Cellular senescence;hsa:5595,path:hsa04510,Focal adhesion;hsa:5595,path:hsa04520,Adherens junction;hsa:5595,path:hsa04540,Gap junction;hsa:5595,path:hsa04550,Signaling pathways regulating pluripotency of stem cells;hsa:5595,path:hsa04810,Regulation of actin cytoskeleton;hsa:5595,path:hsa04611,Platelet activation;hsa:5595,path:hsa04620,Toll-like receptor signaling pathway;hsa:5595,path:hsa04621,NOD-like receptor signaling pathway;hsa:5595,path:hsa04625,C-type lectin receptor signaling pathway;hsa:5595,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:5595,path:hsa04660,T cell receptor signaling pathway;hsa:5595,path:hsa04658,Th1 and Th2 cell differentiation;hsa:5595,path:hsa04659,Th17 cell differentiation;hsa:5595,path:hsa04657,IL-17 signaling pathway;hsa:5595,path:hsa04662,B cell receptor signaling pathway;hsa:5595,path:hsa04664,Fc epsilon RI signaling pathway;hsa:5595,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:5595,path:hsa04062,Chemokine signaling pathway;hsa:5595,path:hsa04910,Insulin signaling pathway;hsa:5595,path:hsa04929,GnRH secretion;hsa:5595,path:hsa04912,GnRH signaling pathway;hsa:5595,path:hsa04915,Estrogen signaling pathway;hsa:5595,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:5595,path:hsa04917,Prolactin signaling pathway;hsa:5595,path:hsa04921,Oxytocin signaling pathway;hsa:5595,path:hsa04926,Relaxin signaling pathway;hsa:5595,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:5595,path:hsa04919,Thyroid hormone signaling pathway;hsa:5595,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:5595,path:hsa04916,Melanogenesis;hsa:5595,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:5595,path:hsa04270,Vascular smooth muscle contraction;hsa:5595,path:hsa04960,Aldosterone-regulated sodium reabsorption;hsa:5595,path:hsa04724,Glutamatergic synapse;hsa:5595,path:hsa04725,Cholinergic synapse;hsa:5595,path:hsa04726,Serotonergic synapse;hsa:5595,path:hsa04720,Long-term potentiation;hsa:5595,path:hsa04730,Long-term depression;hsa:5595,path:hsa04723,Retrograde endocannabinoid signaling;hsa:5595,path:hsa04722,Neurotrophin signaling pathway;hsa:5595,path:hsa04360,Axon guidance;hsa:5595,path:hsa04380,Osteoclast differentiation;hsa:5595,path:hsa04713,Circadian entrainment;hsa:5595,path:hsa05200,Pathways in cancer;hsa:5595,path:hsa05206,MicroRNAs in cancer;hsa:5595,path:hsa05205,Proteoglycans in cancer;hsa:5595,path:hsa05203,Viral carcinogenesis;hsa:5595,path:hsa05230,Central carbon metabolism in cancer;hsa:5595,path:hsa05231,Choline metabolism in cancer;hsa:5595,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:5595,path:hsa05210,Colorectal cancer;hsa:5595,path:hsa05212,Pancreatic cancer;hsa:5595,path:hsa05225,Hepatocellular carcinoma;hsa:5595,path:hsa05226,Gastric cancer;hsa:5595,path:hsa05214,Glioma;hsa:5595,path:hsa05216,Thyroid cancer;hsa:5595,path:hsa05221,Acute myeloid leukemia;hsa:5595,path:hsa05220,Chronic myeloid leukemia;hsa:5595,path:hsa05218,Melanoma;hsa:5595,path:hsa05211,Renal cell carcinoma;hsa:5595,path:hsa05219,Bladder cancer;hsa:5595,path:hsa05215,Prostate cancer;hsa:5595,path:hsa05213,Endometrial cancer;hsa:5595,path:hsa05224,Breast cancer;hsa:5595,path:hsa05223,Non-small cell lung cancer;hsa:5595,path:hsa05010,Alzheimer disease;hsa:5595,path:hsa05020,Prion diseases;hsa:5595,path:hsa05034,Alcoholism;hsa:5595,path:hsa04930,Type II diabetes mellitus;hsa:5595,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:5595,path:hsa04934,Cushing syndrome;hsa:5595,path:hsa05130,Pathogenic Escherichia coli infection;hsa:5595,path:hsa05132,Salmonella infection;hsa:5595,path:hsa05131,Shigellosis;hsa:5595,path:hsa05135,Yersinia infection;hsa:5595,path:hsa05133,Pertussis;hsa:5595,path:hsa05152,Tuberculosis;hsa:5595,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:5595,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:5595,path:hsa05164,Influenza A;hsa:5595,path:hsa05161,Hepatitis B;hsa:5595,path:hsa05160,Hepatitis C;hsa:5595,path:hsa05163,Human cytomegalovirus infection;hsa:5595,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:5595,path:hsa05165,Human papillomavirus infection;hsa:5595,path:hsa05145,Toxoplasmosis;hsa:5595,path:hsa05140,Leishmaniasis;hsa:5595,path:hsa05142,Chagas disease (American trypanosomiasis);hsa:5595,path:hsa01521,EGFR tyrosine kinase inhibitor resistance;hsa:5595,path:hsa01524,Platinum drug resistance;hsa:5595,path:hsa01522,Endocrine resistance
AASD1_HUMAN	Q9BTE6	AARSD1	Alanyl-tRNA editing protein Aarsd1	0.054141884	0.022266505	0.051033021	0.02863958	0.0382041945	0.0398363005	0.0382041945	0.0398363005	0.959029679475382	0.447259	0	1.04272059707999	0.447092	0	GO:0005737,cytoplasm;GO:0005634,nucleus	GO:0004813,alanine-tRNA ligase activity;GO:0005524,ATP binding;GO:0046872,metal ion binding;GO:0003676,nucleic acid binding;GO:0002196,Ser-tRNA(Ala) hydrolase activity;GO:0000166,nucleotide binding;GO:0004812,aminoacyl-tRNA ligase activity	GO:0006419,alanyl-tRNA aminoacylation;GO:0006450,regulation of translational fidelity;GO:0043039,tRNA aminoacylation	
GT251_HUMAN	Q8NBJ5	COLGALT1	Procollagen galactosyltransferase 1	2.912369872	4.136556813	3.461145872	2.682254833	3.5244633425	3.0717003525	3.5244633425	3.0717003525	1.14739816324581	0.388305	0	0.871537040961577	0.388014	0	GO:0005788,endoplasmic reticulum lumen;GO:0016020,membrane	GO:0050211,procollagen galactosyltransferase activity	GO:0030199,collagen fibril organization;GO:1904028,positive regulation of collagen fibril organization	hsa:79709,path:hsa00310,Lysine degradation;hsa:79709,path:hsa00514,Other types of O-glycan biosynthesis
RL30_HUMAN	P62888	RPL30	60S ribosomal protein L30	3.983513715	4.35170418	1.441631892	1.306994199	4.1676089475	1.3743130455	4.1676089475	1.3743130455	3.03250337406478	0.135033	0	0.329760556427541	0.134472	0	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005634,nucleus;GO:0042788,polysomal ribosome;GO:0014069,postsynaptic density	GO:0003723,RNA binding;GO:0035368,selenocysteine insertion sequence binding;GO:0003735,structural constituent of ribosome	GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0002181,cytoplasmic translation;GO:0050829,defense response to Gram-negative bacterium;GO:0031640,killing of cells of other organism;GO:0097421,liver regeneration;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:1904571,positive regulation of selenocysteine incorporation;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6156,path:hsa03010,Ribosome
OSBL5_HUMAN	Q9H0X9	OSBPL5	Oxysterol-binding protein-related protein 5	0.119559513	0.014839969	0.033656339	0.209565601	0.067199741	0.12161097	0.067199741	0.12161097	0.552579598699032	0.273540	0	1.80969402843383	0.273845	0	GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0140268,endoplasmic reticulum-plasma membrane contact site;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane	GO:0015485,cholesterol binding;GO:0008142,oxysterol binding;GO:0070273,phosphatidylinositol-4-phosphate binding;GO:0001786,phosphatidylserine binding;GO:0140343,phosphatidylserine transfer activity;GO:0032934,sterol binding;GO:0015248,sterol transporter activity;GO:0008289,lipid binding	GO:0008203,cholesterol metabolic process;GO:0030301,cholesterol transport;GO:0006893,Golgi to plasma membrane transport;GO:0036150,phosphatidylserine acyl-chain remodeling;GO:0015914,phospholipid transport;GO:0006869,lipid transport	hsa:114879,path:hsa04979,Cholesterol metabolism
C1QBP_HUMAN	Q07021	C1QBP	Complement component 1 Q subcomponent-binding protein, mitochondrial	1.095266577	0.168453499	1.187338537	0.381270928	0.631860038	0.7843047325	0.631860038	0.7843047325	0.805630785862943	0.489644	0	1.2412633895673	0.489746	0	GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005615,extracellular space;GO:0098982,GABA-ergic synapse;GO:0098978,glutamatergic synapse;GO:0016020,membrane;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0048786,presynaptic active zone	GO:0031690,adrenergic receptor binding;GO:0001849,complement component C1q complex binding;GO:0005540,hyaluronic acid binding;GO:0030984,kininogen binding;GO:0097177,mitochondrial ribosome binding;GO:0003729,mRNA binding;GO:0005080,protein kinase C binding;GO:0003714,transcription corepressor activity;GO:0008134,transcription factor binding;GO:0008494,translation activator activity	GO:0007597,blood coagulation, intrinsic pathway;GO:0006958,complement activation, classical pathway;GO:0006955,immune response;GO:0045087,innate immune response;GO:0097193,intrinsic apoptotic signaling pathway;GO:0042256,mature ribosome assembly;GO:0006397,mRNA processing;GO:0050687,negative regulation of defense response to virus;GO:0032689,negative regulation of interferon-gamma production;GO:0032695,negative regulation of interleukin-12 production;GO:0039534,negative regulation of MDA-5 signaling pathway;GO:0048025,negative regulation of mRNA splicing, via spliceosome;GO:0039536,negative regulation of RIG-I signaling pathway;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0014065,phosphatidylinositol 3-kinase signaling;GO:0043065,positive regulation of apoptotic process;GO:0045785,positive regulation of cell adhesion;GO:2000510,positive regulation of dendritic cell chemotaxis;GO:0070131,positive regulation of mitochondrial translation;GO:0090023,positive regulation of neutrophil chemotaxis;GO:0051897,positive regulation of protein kinase B signaling;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:1901165,positive regulation of trophoblast cell migration;GO:0030449,regulation of complement activation;GO:0008380,RNA splicing;GO:0016032,viral process;GO:0002250,adaptive immune response	
RSMB_HUMAN	P14678	SNRPB	Small nuclear ribonucleoprotein-associated proteins B and B'	2.004146588	2.644843906	1.206071464	0.644876247	2.324495247	0.9254738555	2.324495247	0.9254738555	2.51168116007357	0.172563	0	0.398139706542493	0.171993	0	GO:0071013,catalytic step 2 spliceosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0071204,histone pre-mRNA 3'end processing complex;GO:0034709,methylosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0030532,small nuclear ribonucleoprotein complex;GO:0034719,SMN-Sm protein complex;GO:0005681,spliceosomal complex;GO:0005697,telomerase holoenzyme complex;GO:0005685,U1 snRNP;GO:0005689,U12-type spliceosomal complex;GO:0005686,U2 snRNP;GO:0071007,U2-type catalytic step 2 spliceosome;GO:0071005,U2-type precatalytic spliceosome;GO:0071004,U2-type prespliceosome;GO:0005687,U4 snRNP;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005682,U5 snRNP;GO:0005683,U7 snRNP	GO:0071208,histone pre-mRNA DCP binding;GO:0003723,RNA binding;GO:0070034,telomerase RNA binding;GO:1990446,U1 snRNP binding;GO:1990447,U2 snRNP binding	GO:0007420,brain development;GO:0008334,histone mRNA metabolic process;GO:0051170,import into nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0006479,protein methylation;GO:0008380,RNA splicing;GO:0000387,spliceosomal snRNP assembly;GO:0006369,termination of RNA polymerase II transcription	hsa:6628,path:hsa03040,Spliceosome;hsa:6628,path:hsa05322,Systemic lupus erythematosus
IF4E_HUMAN	P06730	EIF4E	Eukaryotic translation initiation factor 4E	1.253363967	0.346660545	0.08372878	0.037911554	0.800012256	0.060820167	0.800012256	0.060820167	13.1537333003377	0.009651	1	0.076024044061645	0.009513	-1	GO:0033391,chromatoid body;GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0016281,eukaryotic translation initiation factor 4F complex;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0005845,mRNA cap binding complex;GO:0005634,nucleus;GO:0000932,P-body;GO:0048471,perinuclear region of cytoplasm;GO:0099524,postsynaptic cytosol;GO:0016442,RISC complex	GO:0019899,enzyme binding;GO:0031370,eukaryotic initiation factor 4G binding;GO:0070491,repressing transcription factor binding;GO:0000340,RNA 7-methylguanosine cap binding;GO:0003723,RNA binding;GO:0000339,RNA cap binding;GO:0003743,translation initiation factor activity	GO:0001662,behavioral fear response;GO:0071549,cellular response to dexamethasone stimulus;GO:0000082,G1/S transition of mitotic cell cycle;GO:0030324,lung development;GO:0006406,mRNA export from nucleus;GO:0045665,negative regulation of neuron differentiation;GO:0017148,negative regulation of translation;GO:0045931,positive regulation of mitotic cell cycle;GO:0006417,regulation of translation;GO:0099578,regulation of translation at postsynapse, modulating synaptic transmission;GO:0006405,RNA export from nucleus;GO:0019827,stem cell population maintenance;GO:0006413,translational initiation;GO:0016032,viral process	hsa:1977,path:hsa03013,RNA transport;hsa:1977,path:hsa04066,HIF-1 signaling pathway;hsa:1977,path:hsa04151,PI3K-Akt signaling pathway;hsa:1977,path:hsa04150,mTOR signaling pathway;hsa:1977,path:hsa04910,Insulin signaling pathway;hsa:1977,path:hsa04211,Longevity regulating pathway;hsa:1977,path:hsa01521,EGFR tyrosine kinase inhibitor resistance
AT5EL_HUMAN	Q5VTU8	ATP5F1EP2	ATP synthase subunit epsilon-like protein, mitochondrial	0.655263547	0.456393026	0.28900171	0.52190203	0.5558282865	0.40545187	0.5558282865	0.40545187	1.37088598580147	0.332240	0	0.729455264957984	0.331843	0	GO:0005743,mitochondrial inner membrane;GO:0000275,mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1);GO:0005739,mitochondrion	GO:0016787,hydrolase activity;GO:0046933,proton-transporting ATP synthase activity, rotational mechanism		
ECM29_HUMAN	Q5VYK3	ECPAS	Proteasome adapter and scaffold protein ECM29	0.702739156	0.259812759	0.798959377	0.573038298	0.4812759575	0.6859988375	0.4812759575	0.6859988375	0.701569640050593	0.406203	0	1.42537524846127	0.406397	0	GO:0005813,centrosome;GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0031410,cytoplasmic vesicle;GO:0005769,early endosome;GO:0030139,endocytic vesicle;GO:0005783,endoplasmic reticulum;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0005770,late endosome;GO:0016020,membrane;GO:0005771,multivesicular body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000502,proteasome complex;GO:0005737,cytoplasm	GO:0060090,molecular adaptor activity;GO:0070628,proteasome binding	GO:0043248,proteasome assembly;GO:0030433,ubiquitin-dependent ERAD pathway	
COX1_HUMAN	P00395	MT-CO1	Cytochrome c oxidase subunit 1	0.226312477	0.294568743	0.829801455	0.208671201	0.26044061	0.519236328	0.26044061	0.519236328	0.501583953116624	0.226593	0	1.99368419541023	0.226921	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0005750,mitochondrial respiratory chain complex III;GO:0005751,mitochondrial respiratory chain complex IV;GO:0045277,respiratory chain complex IV;GO:0005739,mitochondrion;GO:0005753,mitochondrial proton-transporting ATP synthase complex;GO:0045263,proton-transporting ATP synthase complex, coupling factor F(o);GO:0000276,mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0031305,integral component of mitochondrial inner membrane;GO:0016020,membrane;GO:0005615,extracellular space;GO:0014069,postsynaptic density;GO:0070469,respirasome;GO:0005576,extracellular region;GO:0048471,perinuclear region of cytoplasm;GO:0030425,dendrite;GO:0031966,mitochondrial membrane;GO:0043025,neuronal cell body;GO:0043005,neuron projection	GO:0008137,NADH dehydrogenase (ubiquinone) activity;GO:0048039,ubiquinone binding;GO:0004129,cytochrome-c oxidase activity;GO:0020037,heme binding;GO:0046872,metal ion binding;GO:0009055,electron transfer activity;GO:0015453,oxidoreduction-driven active transmembrane transporter activity;GO:0015078,proton transmembrane transporter activity;GO:0044877,protein-containing complex binding;GO:0008121,ubiquinol-cytochrome-c reductase activity;GO:0005507,copper ion binding;GO:0035255,ionotropic glutamate receptor binding;GO:0019901,protein kinase binding;GO:0048019,receptor antagonist activity;GO:0005102,signaling receptor binding;GO:0003954,NADH dehydrogenase activity	GO:0009060,aerobic respiration;GO:0007568,aging;GO:0021549,cerebellum development;GO:0015990,electron transport coupled proton transport;GO:0001701,in utero embryonic development;GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0045471,response to ethanol;GO:0001666,response to hypoxia;GO:0035094,response to nicotine;GO:0006123,mitochondrial electron transport, cytochrome c to oxygen;GO:0022904,respiratory electron transport chain;GO:0046688,response to copper ion;GO:0051602,response to electrical stimulus;GO:0006979,response to oxidative stress;GO:0008535,respiratory chain complex IV assembly;GO:0006754,ATP biosynthetic process;GO:0015986,ATP synthesis coupled proton transport;GO:0042407,cristae formation;GO:0042776,mitochondrial ATP synthesis coupled proton transport;GO:0055093,response to hyperoxia;GO:0031100,animal organ regeneration;GO:0042538,hyperosmotic salinity response;GO:0006122,mitochondrial electron transport, ubiquinol to cytochrome c;GO:0046686,response to cadmium ion;GO:0051592,response to calcium ion;GO:0033590,response to cobalamin;GO:0042493,response to drug;GO:0033762,response to glucagon;GO:0009408,response to heat;GO:0046689,response to mercury ion;GO:0009636,response to toxic substance;GO:0042773,ATP synthesis coupled electron transport;GO:0007595,lactation;GO:2001171,positive regulation of ATP biosynthetic process;GO:0010729,positive regulation of hydrogen peroxide biosynthetic process;GO:0010940,positive regulation of necrotic cell death;GO:0009409,response to cold;GO:0032147,activation of protein kinase activity;GO:0072522,purine-containing compound biosynthetic process;GO:0043610,regulation of carbohydrate utilization;GO:0072593,reactive oxygen species metabolic process;GO:0042220,response to cocaine;GO:0042542,response to hydrogen peroxide;GO:0006915,apoptotic process;GO:0006879,cellular iron ion homeostasis;GO:0007186,G protein-coupled receptor signaling pathway;GO:0030595,leukocyte chemotaxis;GO:0043066,negative regulation of apoptotic process;GO:1900118,negative regulation of execution phase of apoptosis;GO:0033194,response to hydroperoxide;GO:0014070,response to organic cyclic compound;GO:0071385,cellular response to glucocorticoid stimulus;GO:0009642,response to light intensity;GO:0010243,response to organonitrogen compound	hsa:4538,path:hsa00190,Oxidative phosphorylation;hsa:4538,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4538,path:hsa04714,Thermogenesis;hsa:4538,path:hsa05012,Parkinson disease;hsa:4512,path:hsa00190,Oxidative phosphorylation;hsa:4512,path:hsa04260,Cardiac muscle contraction;hsa:4512,path:hsa04714,Thermogenesis;hsa:4512,path:hsa05010,Alzheimer disease;hsa:4512,path:hsa05012,Parkinson disease;hsa:4512,path:hsa05016,Huntington disease;hsa:4512,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4514,path:hsa00190,Oxidative phosphorylation;hsa:4514,path:hsa04260,Cardiac muscle contraction;hsa:4514,path:hsa04714,Thermogenesis;hsa:4514,path:hsa05010,Alzheimer disease;hsa:4514,path:hsa05012,Parkinson disease;hsa:4514,path:hsa05016,Huntington disease;hsa:4514,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4508,path:hsa00190,Oxidative phosphorylation;hsa:4508,path:hsa04714,Thermogenesis;hsa:4508,path:hsa05010,Alzheimer disease;hsa:4508,path:hsa05012,Parkinson disease;hsa:4508,path:hsa05016,Huntington disease;hsa:4509,path:hsa00190,Oxidative phosphorylation;hsa:4509,path:hsa04714,Thermogenesis;hsa:4509,path:hsa05010,Alzheimer disease;hsa:4509,path:hsa05012,Parkinson disease;hsa:4509,path:hsa05016,Huntington disease;hsa:4519,path:hsa00190,Oxidative phosphorylation;hsa:4519,path:hsa04260,Cardiac muscle contraction;hsa:4519,path:hsa04714,Thermogenesis;hsa:4519,path:hsa05010,Alzheimer disease;hsa:4519,path:hsa05012,Parkinson disease;hsa:4519,path:hsa05016,Huntington disease;hsa:4519,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4513,path:hsa00190,Oxidative phosphorylation;hsa:4513,path:hsa04260,Cardiac muscle contraction;hsa:4513,path:hsa04714,Thermogenesis;hsa:4513,path:hsa05010,Alzheimer disease;hsa:4513,path:hsa05012,Parkinson disease;hsa:4513,path:hsa05016,Huntington disease;hsa:4513,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4536,path:hsa00190,Oxidative phosphorylation;hsa:4536,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4536,path:hsa04714,Thermogenesis;hsa:4536,path:hsa05012,Parkinson disease;hsa:4541,path:hsa00190,Oxidative phosphorylation;hsa:4541,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4541,path:hsa04714,Thermogenesis;hsa:4541,path:hsa05012,Parkinson disease;hsa:4539,path:hsa00190,Oxidative phosphorylation;hsa:4539,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4539,path:hsa04714,Thermogenesis;hsa:4539,path:hsa05012,Parkinson disease;hsa:4535,path:hsa00190,Oxidative phosphorylation;hsa:4535,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4535,path:hsa04714,Thermogenesis;hsa:4535,path:hsa05012,Parkinson disease;hsa:4537,path:hsa00190,Oxidative phosphorylation;hsa:4537,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4537,path:hsa04714,Thermogenesis;hsa:4537,path:hsa05012,Parkinson disease;hsa:4540,path:hsa00190,Oxidative phosphorylation;hsa:4540,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4540,path:hsa04714,Thermogenesis;hsa:4540,path:hsa05012,Parkinson disease
PRG2_HUMAN	P13727	PRG2	Bone marrow proteoglycan	2.413318306	10.8074518	2.879414724	3.140679517	6.610385053	3.0100471205	6.610385053	3.0100471205	2.19610683433485	0.203010	0	0.455351253575455	0.202451	0	GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0030133,transport vesicle	GO:0030246,carbohydrate binding;GO:0030021,extracellular matrix structural constituent conferring compression resistance;GO:0008201,heparin binding	GO:0042742,defense response to bacterium;GO:0043312,neutrophil degranulation	hsa:5553,path:hsa05310,Asthma
DHPR_HUMAN	P09417	QDPR	Dihydropteridine reductase	0.687242052	1.513116953	1.265419238	2.107750176	1.1001795025	1.686584707	1.1001795025	1.686584707	0.652312035045626	0.363705	0	1.5330086619206	0.363941	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0043005,neuron projection	GO:0004155,6,7-dihydropteridine reductase activity;GO:0009055,electron transfer activity;GO:0042802,identical protein binding;GO:0070404,NADH binding;GO:0070402,NADPH binding	GO:0006520,cellular amino acid metabolic process;GO:0035690,cellular response to drug;GO:0051066,dihydrobiopterin metabolic process;GO:0006559,L-phenylalanine catabolic process;GO:0006558,L-phenylalanine metabolic process;GO:0001889,liver development;GO:0010044,response to aluminum ion;GO:0033762,response to glucagon;GO:0010288,response to lead ion;GO:0006729,tetrahydrobiopterin biosynthetic process	hsa:5860,path:hsa00790,Folate biosynthesis
DPM1_HUMAN	O60762	DPM1	Dolichol-phosphate mannosyltransferase subunit 1	4.459631969	2.175366611	6.456229755	7.973491008	3.31749929	7.2148603815	3.31749929	7.2148603815	0.45981475934123	0.188621	0	2.17478882459685	0.188957	0	GO:0033185,dolichol-phosphate-mannose synthase complex;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016020,membrane;GO:0005634,nucleus	GO:0004582,dolichyl-phosphate beta-D-mannosyltransferase activity;GO:0004169,dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0043178,alcohol binding;GO:0005537,mannose binding	GO:0019348,dolichol metabolic process;GO:0006506,GPI anchor biosynthetic process;GO:0035268,protein mannosylation;GO:0018279,protein N-linked glycosylation via asparagine;GO:0035269,protein O-linked mannosylation;GO:0006486,protein glycosylation;GO:0019673,GDP-mannose metabolic process	hsa:8813,path:hsa00510,N-Glycan biosynthesis
PSB4_HUMAN	P28070	PSMB4	Proteasome subunit beta type-4	4.208433582	8.758089048	2.459877782	1.904982293	6.483261315	2.1824300375	6.483261315	2.1824300375	2.97066169526637	0.138840	0	0.336625338924812	0.138277	0	GO:0036064,ciliary basal body;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000502,proteasome complex;GO:0005839,proteasome core complex;GO:0019774,proteasome core complex, beta-subunit complex	GO:0004175,endopeptidase activity;GO:0001530,lipopolysaccharide binding;GO:0004298,threonine-type endopeptidase activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5692,path:hsa03050,Proteasome
PFKAL_HUMAN	P17858	PFKL	ATP-dependent 6-phosphofructokinase, liver type	6.261289256	7.488496844	9.306582646	9.887189169	6.87489305	9.5968859075	6.87489305	9.5968859075	0.716367071179542	0.418620	0	1.39593239308646	0.418801	0	GO:0005945,6-phosphofructokinase complex;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0034774,secretory granule lumen	GO:0003872,6-phosphofructokinase activity;GO:0016208,AMP binding;GO:0005524,ATP binding;GO:0070061,fructose binding;GO:0070095,fructose-6-phosphate binding;GO:0042802,identical protein binding;GO:0019900,kinase binding;GO:0046872,metal ion binding;GO:0048029,monosaccharide binding	GO:0061621,canonical glycolysis;GO:0030388,fructose 1,6-bisphosphate metabolic process;GO:0006002,fructose 6-phosphate metabolic process;GO:0006096,glycolytic process;GO:0046676,negative regulation of insulin secretion;GO:0043312,neutrophil degranulation;GO:0009749,response to glucose	hsa:5211,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:5211,path:hsa00030,Pentose phosphate pathway;hsa:5211,path:hsa00051,Fructose and mannose metabolism;hsa:5211,path:hsa00052,Galactose metabolism;hsa:5211,path:hsa03018,RNA degradation;hsa:5211,path:hsa04066,HIF-1 signaling pathway;hsa:5211,path:hsa04152,AMPK signaling pathway;hsa:5211,path:hsa04922,Glucagon signaling pathway;hsa:5211,path:hsa05230,Central carbon metabolism in cancer
SEC13_HUMAN	P55735	SEC13	Protein SEC13 homolog	0.668900499	0.509281638	0.848292148	1.552481384	0.5890910685	1.200386766	0.5890910685	1.200386766	0.49075105223211	0.216672	0	2.03769303285575	0.217003	0	GO:0030127,COPII vesicle coat;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0070062,extracellular exosome;GO:0061700,GATOR2 complex;GO:0043657,host cell;GO:0043231,intracellular membrane-bounded organelle;GO:0005765,lysosomal membrane;GO:0005635,nuclear envelope;GO:0031080,nuclear pore outer ring;GO:0005654,nucleoplasm;GO:0005643,nuclear pore	GO:0042802,identical protein binding;GO:0005198,structural molecule activity	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0034198,cellular response to amino acid starvation;GO:0048208,COPII vesicle coating;GO:0090114,COPII-coated vesicle budding;GO:0090110,COPII-coated vesicle cargo loading;GO:0006886,intracellular protein transport;GO:0075733,intracellular transport of virus;GO:0007084,mitotic nuclear envelope reassembly;GO:0007052,mitotic spindle organization;GO:0006406,mRNA export from nucleus;GO:0032008,positive regulation of TOR signaling;GO:1904263,positive regulation of TORC1 signaling;GO:0032527,protein exit from endoplasmic reticulum;GO:0006606,protein import into nucleus;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription;GO:0051028,mRNA transport;GO:0015031,protein transport	hsa:6396,path:hsa03013,RNA transport;hsa:6396,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:6396,path:hsa04150,mTOR signaling pathway
IF2GL_HUMAN	Q2VIR3	EIF2S3B	Eukaryotic translation initiation factor 2 subunit 3B	0.034474016	2.55E-05	0.045893973	2.55E-05	0.017249758	0.0229597365	0.017249758	0.0229597365	0.751304702473393	0.447234	0	1.331017890222	0.447384	0	GO:0005829,cytosol;GO:0005850,eukaryotic translation initiation factor 2 complex	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0003743,translation initiation factor activity;GO:0000049,tRNA binding	GO:0001731,formation of translation preinitiation complex;GO:0045903,positive regulation of translational fidelity	
SRSF6_HUMAN	Q13247	SRSF6	Serine/arginine-rich splicing factor 6	7.902340634	13.64563484	7.281184029	8.453609254	10.773987737	7.8673966415	10.773987737	7.8673966415	1.3694476366131	0.332561	0	0.730221421589502	0.332165	0	GO:0016607,nuclear speck;GO:0005654,nucleoplasm	GO:0003729,mRNA binding;GO:0036002,pre-mRNA binding;GO:0003723,RNA binding	GO:0000380,alternative mRNA splicing, via spliceosome;GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0006376,mRNA splice site selection;GO:0000398,mRNA splicing, via spliceosome;GO:0060548,negative regulation of cell death;GO:0045617,negative regulation of keratinocyte differentiation;GO:0048025,negative regulation of mRNA splicing, via spliceosome;GO:2000675,negative regulation of type B pancreatic cell apoptotic process;GO:0060501,positive regulation of epithelial cell proliferation involved in lung morphogenesis;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0010837,regulation of keratinocyte proliferation;GO:0061041,regulation of wound healing;GO:0032868,response to insulin;GO:0006405,RNA export from nucleus	hsa:6431,path:hsa03040,Spliceosome;hsa:6431,path:hsa05168,Herpes simplex virus 1 infection
SKP1_HUMAN	P63208	SKP1	S-phase kinase-associated protein 1	0.583186264	2.650951195	0.078523127	0.036773612	1.6170687295	0.0576483695	1.6170687295	0.0576483695	28.0505544827248	0.001451	1	0.0356499191706125	0.001419	-1	GO:0005813,centrosome;GO:0031467,Cul7-RING ubiquitin ligase complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0019005,SCF ubiquitin ligase complex	GO:0008013,beta-catenin binding;GO:0097602,cullin family protein binding;GO:1990444,F-box domain binding;GO:0019904,protein domain specific binding;GO:1990756,ubiquitin ligase-substrate adaptor activity	GO:0006879,cellular iron ion homeostasis;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0000086,G2/M transition of mitotic cell cycle;GO:0035518,histone H2A monoubiquitination;GO:0070498,interleukin-1-mediated signaling pathway;GO:0051457,maintenance of protein location in nucleus;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:1904668,positive regulation of ubiquitin protein ligase activity;GO:0043687,post-translational protein modification;GO:0070936,protein K48-linked ubiquitination;GO:0000209,protein polyubiquitination;GO:0016567,protein ubiquitination;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0010265,SCF complex assembly;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0051403,stress-activated MAPK cascade;GO:0050852,T cell receptor signaling pathway;GO:0016032,viral process;GO:0016055,Wnt signaling pathway;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:6500,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:6500,path:hsa04120,Ubiquitin mediated proteolysis;hsa:6500,path:hsa04310,Wnt signaling pathway;hsa:6500,path:hsa04350,TGF-beta signaling pathway;hsa:6500,path:hsa04110,Cell cycle;hsa:6500,path:hsa04114,Oocyte meiosis;hsa:6500,path:hsa04710,Circadian rhythm;hsa:6500,path:hsa05200,Pathways in cancer;hsa:6500,path:hsa05132,Salmonella infection;hsa:6500,path:hsa05131,Shigellosis;hsa:6500,path:hsa05170,Human immunodeficiency virus 1 infection
MMRN2_HUMAN	Q9H8L6	MMRN2	Multimerin-2	0.078631895	0.226853002	0.385170756	2.233643009	0.1527424485	1.3094068825	0.1527424485	1.3094068825	0.116650103601391	0.001445	-1	8.57264562247737	0.001463	1	GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005615,extracellular space		GO:0002042,cell migration involved in sprouting angiogenesis;GO:0090051,negative regulation of cell migration involved in sprouting angiogenesis;GO:0030948,negative regulation of vascular endothelial growth factor receptor signaling pathway	
SGT1_HUMAN	Q9Y2Z0	SUGT1	Protein SGT1 homolog	0.97796098	0.353394838	0.802898989	0.356840075	0.665677909	0.579869532	0.665677909	0.579869532	1.14797876464391	0.388142	0	0.871096252647315	0.387850	0	GO:0005829,cytosol;GO:0000776,kinetochore;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0000151,ubiquitin ligase complex	GO:0051087,chaperone binding	GO:0000278,mitotic cell cycle;GO:0043947,positive regulation by host of symbiont catalytic activity;GO:0050821,protein stabilization;GO:0035590,purinergic nucleotide receptor signaling pathway;GO:0031647,regulation of protein stability	hsa:10910,path:hsa04621,NOD-like receptor signaling pathway
ASNS_HUMAN	P08243	ASNS	Asparagine synthetase [glutamine-hydrolyzing]	0.643501564	0.177697165	0.664590853	0.326636938	0.4105993645	0.4956138955	0.4105993645	0.4956138955	0.828466207723589	0.496314	0	1.20704983580168	0.496256	0	GO:0005829,cytosol	GO:0004066,asparagine synthase (glutamine-hydrolyzing) activity;GO:0005524,ATP binding;GO:0042802,identical protein binding	GO:0006529,asparagine biosynthetic process;GO:0009066,aspartate family amino acid metabolic process;GO:0042149,cellular response to glucose starvation;GO:0032870,cellular response to hormone stimulus;GO:0006541,glutamine metabolic process;GO:0070981,L-asparagine biosynthetic process;GO:0001889,liver development;GO:0043066,negative regulation of apoptotic process;GO:0045931,positive regulation of mitotic cell cycle;GO:0043200,response to amino acid;GO:0032354,response to follicle-stimulating hormone;GO:0009416,response to light stimulus;GO:0009612,response to mechanical stimulus;GO:0031427,response to methotrexate;GO:0009636,response to toxic substance	hsa:440,path:hsa00250,Alanine, aspartate and glutamate metabolism
EMC7_HUMAN	Q9NPA0	EMC7	ER membrane protein complex subunit 7	0.351412818	0.760473935	0.067455717	0.005503791	0.5559433765	0.036479754	0.5559433765	0.036479754	15.2397786591434	0.006875	1	0.0656177509113646	0.006768	-1	GO:0072546,EMC complex;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016021,integral component of membrane	GO:0030246,carbohydrate binding	GO:0045050,protein insertion into ER membrane by stop-transfer membrane-anchor sequence;GO:0071816,tail-anchored membrane protein insertion into ER membrane	
HV146_HUMAN	P01743	IGHV1-46	Immunoglobulin heavy variable 1-46	0.133512024	0.026405301	0.17254188	0.352539799	0.0799586625	0.2625408395	0.0799586625	0.2625408395	0.304557045876285	0.065196	0	3.28345711760749	0.065446	0	GO:0009897,external side of plasma membrane;GO:0042571,immunoglobulin complex, circulating;GO:0005576,extracellular region;GO:0005886,plasma membrane;GO:0019814,immunoglobulin complex	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006956,complement activation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
DRB3_HUMAN	P79483	HLA-DRB3	HLA class II histocompatibility antigen, DR beta 3 chain	1.676003082	15.14417761	3.436204162	9.923598491	8.410090346	6.6799013265	8.410090346	6.6799013265	1.25901415828347	0.358682	0	0.794272243422104	0.358333	0	GO:0009986,cell surface;GO:0031901,early endosome membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0000139,Golgi membrane;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0042612,MHC class I protein complex;GO:0032398,MHC class Ib protein complex;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0030667,secretory granule membrane;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0030666,endocytic vesicle membrane;GO:0001772,immunological synapse;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0042613,MHC class II protein complex;GO:0032588,trans-Golgi network membrane;GO:0030658,transport vesicle membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0010008,endosome membrane;GO:0005882,intermediate filament;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0005797,Golgi medial cisterna;GO:0042824,MHC class I peptide loading complex;GO:0035577,azurophil granule membrane;GO:0033106,cis-Golgi network membrane;GO:0005769,early endosome;GO:0031527,filopodium membrane;GO:0005771,multivesicular body	GO:0030881,beta-2-microglobulin binding;GO:0042288,MHC class I protein binding;GO:0046703,natural killer cell lectin-like receptor binding;GO:0042605,peptide antigen binding;GO:0005102,signaling receptor binding;GO:0042608,T cell receptor binding;GO:0051087,chaperone binding;GO:0046977,TAP binding;GO:0023026,MHC class II protein complex binding;GO:0032395,MHC class II receptor activity;GO:0030247,polysaccharide binding;GO:0042609,CD4 receptor binding;GO:0005200,structural constituent of cytoskeleton;GO:0042610,CD8 receptor binding;GO:0003723,RNA binding;GO:0062061,TAP complex binding;GO:0071889,14-3-3 protein binding;GO:0046978,TAP1 binding;GO:0046979,TAP2 binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:1990405,protein antigen binding;GO:0015643,toxic substance binding;GO:0008134,transcription factor binding;GO:0031625,ubiquitin protein ligase binding;GO:0046872,metal ion binding	GO:0002250,adaptive immune response;GO:0019731,antibacterial humoral response;GO:0002476,antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0002477,antigen processing and presentation of exogenous peptide antigen via MHC class Ib;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0036037,CD8-positive, alpha-beta T cell activation;GO:0050830,defense response to Gram-positive bacterium;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0002519,natural killer cell tolerance induction;GO:0045953,negative regulation of natural killer cell mediated cytotoxicity;GO:0001815,positive regulation of antibody-dependent cellular cytotoxicity;GO:2001187,positive regulation of CD8-positive, alpha-beta T cell activation;GO:2000566,positive regulation of CD8-positive, alpha-beta T cell proliferation;GO:0002639,positive regulation of immunoglobulin production;GO:0032736,positive regulation of interleukin-13 production;GO:0032753,positive regulation of interleukin-4 production;GO:0002729,positive regulation of natural killer cell cytokine production;GO:0045954,positive regulation of natural killer cell mediated cytotoxicity;GO:0002717,positive regulation of natural killer cell mediated immunity;GO:0032819,positive regulation of natural killer cell proliferation;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:0032759,positive regulation of TRAIL production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0042270,protection from natural killer cell mediated cytotoxicity;GO:0050776,regulation of immune response;GO:0002715,regulation of natural killer cell mediated immunity;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process;GO:0002486,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006952,defense response;GO:0016045,detection of bacterium;GO:0006955,immune response;GO:0043312,neutrophil degranulation;GO:2001198,regulation of dendritic cell differentiation;GO:0032655,regulation of interleukin-12 production;GO:0032675,regulation of interleukin-6 production;GO:0002667,regulation of T cell anergy;GO:0002491,antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002504,antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0050890,cognition;GO:0002469,myeloid dendritic cell antigen processing and presentation;GO:0002503,peptide antigen assembly with MHC class II protein complex;GO:2000516,positive regulation of CD4-positive, alpha-beta T cell activation;GO:0032831,positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0043382,positive regulation of memory T cell differentiation;GO:0045622,regulation of T-helper cell differentiation;GO:0050852,T cell receptor signaling pathway;GO:0002399,MHC class II protein complex assembly;GO:2001190,positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0042102,positive regulation of T cell proliferation;GO:0032729,positive regulation of interferon-gamma production;GO:0050870,positive regulation of T cell activation;GO:0008544,epidermis development;GO:0006959,humoral immune response;GO:0002437,inflammatory response to antigenic stimulus;GO:0030225,macrophage differentiation;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0032689,negative regulation of interferon-gamma production;GO:0042130,negative regulation of T cell proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0033674,positive regulation of kinase activity;GO:0043410,positive regulation of MAPK cascade;GO:0045657,positive regulation of monocyte differentiation;GO:0001934,positive regulation of protein phosphorylation;GO:0002842,positive regulation of T cell mediated immune response to tumor cell;GO:0045893,positive regulation of transcription, DNA-templated;GO:0046598,positive regulation of viral entry into host cell;GO:0051262,protein tetramerization;GO:0032653,regulation of interleukin-10 production;GO:0032673,regulation of interleukin-4 production;GO:0007165,signal transduction;GO:0042088,T-helper 1 type immune response;GO:0002587,negative regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0045580,regulation of T cell differentiation;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002485,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent;GO:0042590,antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:2000568,positive regulation of memory T cell activation;GO:0002726,positive regulation of T cell cytokine production;GO:0016567,protein ubiquitination;GO:0001913,T cell mediated cytotoxicity;GO:0002419,T cell mediated cytotoxicity directed against tumor cell target;GO:0002728,negative regulation of natural killer cell cytokine production;GO:0043322,negative regulation of natural killer cell degranulation;GO:1901215,negative regulation of neuron death;GO:0002725,negative regulation of T cell cytokine production;GO:0043323,positive regulation of natural killer cell degranulation;GO:0071346,cellular response to interferon-gamma;GO:0006968,cellular defense response;GO:0002767,immune response-inhibiting cell surface receptor signaling pathway;GO:0016525,negative regulation of angiogenesis;GO:2001199,negative regulation of dendritic cell differentiation;GO:0070317,negative regulation of G0 to G1 transition;GO:0050777,negative regulation of immune response;GO:0051898,negative regulation of protein kinase B signaling;GO:0001915,negative regulation of T cell mediated cytotoxicity;GO:0002451,peripheral B cell tolerance induction;GO:2000774,positive regulation of cellular senescence;GO:2000353,positive regulation of endothelial cell apoptotic process;GO:0032735,positive regulation of interleukin-12 production;GO:0060907,positive regulation of macrophage cytokine production;GO:0045591,positive regulation of regulatory T cell differentiation;GO:0002666,positive regulation of T cell tolerance induction;GO:0002645,positive regulation of tolerance induction;GO:0070207,protein homotrimerization;GO:0019882,antigen processing and presentation;GO:0002344,B cell affinity maturation;GO:0046635,positive regulation of alpha-beta T cell activation;GO:0002579,positive regulation of antigen processing and presentation;GO:0002827,positive regulation of T-helper 1 type immune response	hsa:3133,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3133,path:hsa04144,Endocytosis;hsa:3133,path:hsa04145,Phagosome;hsa:3133,path:hsa04218,Cellular senescence;hsa:3133,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3133,path:hsa04612,Antigen processing and presentation;hsa:3133,path:hsa05203,Viral carcinogenesis;hsa:3133,path:hsa05320,Autoimmune thyroid disease;hsa:3133,path:hsa05330,Allograft rejection;hsa:3133,path:hsa05332,Graft-versus-host disease;hsa:3133,path:hsa05416,Viral myocarditis;hsa:3133,path:hsa04940,Type I diabetes mellitus;hsa:3133,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3133,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3133,path:hsa05168,Herpes simplex virus 1 infection;hsa:3133,path:hsa05163,Human cytomegalovirus infection;hsa:3133,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3133,path:hsa05169,Epstein-Barr virus infection;hsa:3133,path:hsa05165,Human papillomavirus infection;hsa:3106,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3106,path:hsa04144,Endocytosis;hsa:3106,path:hsa04145,Phagosome;hsa:3106,path:hsa04218,Cellular senescence;hsa:3106,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3106,path:hsa04612,Antigen processing and presentation;hsa:3106,path:hsa05203,Viral carcinogenesis;hsa:3106,path:hsa05320,Autoimmune thyroid disease;hsa:3106,path:hsa05330,Allograft rejection;hsa:3106,path:hsa05332,Graft-versus-host disease;hsa:3106,path:hsa05416,Viral myocarditis;hsa:3106,path:hsa04940,Type I diabetes mellitus;hsa:3106,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3106,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3106,path:hsa05168,Herpes simplex virus 1 infection;hsa:3106,path:hsa05163,Human cytomegalovirus infection;hsa:3106,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3106,path:hsa05169,Epstein-Barr virus infection;hsa:3106,path:hsa05165,Human papillomavirus infection;hsa:3122,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3122,path:hsa04145,Phagosome;hsa:3122,path:hsa04640,Hematopoietic cell lineage;hsa:3122,path:hsa04612,Antigen processing and presentation;hsa:3122,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3122,path:hsa04659,Th17 cell differentiation;hsa:3122,path:hsa04672,Intestinal immune network for IgA production;hsa:3122,path:hsa05310,Asthma;hsa:3122,path:hsa05322,Systemic lupus erythematosus;hsa:3122,path:hsa05323,Rheumatoid arthritis;hsa:3122,path:hsa05320,Autoimmune thyroid disease;hsa:3122,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3122,path:hsa05330,Allograft rejection;hsa:3122,path:hsa05332,Graft-versus-host disease;hsa:3122,path:hsa05416,Viral myocarditis;hsa:3122,path:hsa04940,Type I diabetes mellitus;hsa:3122,path:hsa05150,Staphylococcus aureus infection;hsa:3122,path:hsa05152,Tuberculosis;hsa:3122,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3122,path:hsa05164,Influenza A;hsa:3122,path:hsa05168,Herpes simplex virus 1 infection;hsa:3122,path:hsa05169,Epstein-Barr virus infection;hsa:3122,path:hsa05145,Toxoplasmosis;hsa:3122,path:hsa05140,Leishmaniasis;hsa:3109,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3109,path:hsa04145,Phagosome;hsa:3109,path:hsa04640,Hematopoietic cell lineage;hsa:3109,path:hsa04612,Antigen processing and presentation;hsa:3109,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3109,path:hsa04659,Th17 cell differentiation;hsa:3109,path:hsa04672,Intestinal immune network for IgA production;hsa:3109,path:hsa05310,Asthma;hsa:3109,path:hsa05322,Systemic lupus erythematosus;hsa:3109,path:hsa05323,Rheumatoid arthritis;hsa:3109,path:hsa05320,Autoimmune thyroid disease;hsa:3109,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3109,path:hsa05330,Allograft rejection;hsa:3109,path:hsa05332,Graft-versus-host disease;hsa:3109,path:hsa05416,Viral myocarditis;hsa:3109,path:hsa04940,Type I diabetes mellitus;hsa:3109,path:hsa05150,Staphylococcus aureus infection;hsa:3109,path:hsa05152,Tuberculosis;hsa:3109,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3109,path:hsa05164,Influenza A;hsa:3109,path:hsa05168,Herpes simplex virus 1 infection;hsa:3109,path:hsa05169,Epstein-Barr virus infection;hsa:3109,path:hsa05145,Toxoplasmosis;hsa:3109,path:hsa05140,Leishmaniasis;hsa:3115,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3115,path:hsa04145,Phagosome;hsa:3115,path:hsa04640,Hematopoietic cell lineage;hsa:3115,path:hsa04612,Antigen processing and presentation;hsa:3115,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3115,path:hsa04659,Th17 cell differentiation;hsa:3115,path:hsa04672,Intestinal immune network for IgA production;hsa:3115,path:hsa05310,Asthma;hsa:3115,path:hsa05322,Systemic lupus erythematosus;hsa:3115,path:hsa05323,Rheumatoid arthritis;hsa:3115,path:hsa05320,Autoimmune thyroid disease;hsa:3115,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3115,path:hsa05330,Allograft rejection;hsa:3115,path:hsa05332,Graft-versus-host disease;hsa:3115,path:hsa05416,Viral myocarditis;hsa:3115,path:hsa04940,Type I diabetes mellitus;hsa:3115,path:hsa05150,Staphylococcus aureus infection;hsa:3115,path:hsa05152,Tuberculosis;hsa:3115,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3115,path:hsa05164,Influenza A;hsa:3115,path:hsa05168,Herpes simplex virus 1 infection;hsa:3115,path:hsa05169,Epstein-Barr virus infection;hsa:3115,path:hsa05145,Toxoplasmosis;hsa:3115,path:hsa05140,Leishmaniasis;hsa:3123,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3123,path:hsa04145,Phagosome;hsa:3123,path:hsa04640,Hematopoietic cell lineage;hsa:3123,path:hsa04612,Antigen processing and presentation;hsa:3123,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3123,path:hsa04659,Th17 cell differentiation;hsa:3123,path:hsa04672,Intestinal immune network for IgA production;hsa:3123,path:hsa05310,Asthma;hsa:3123,path:hsa05322,Systemic lupus erythematosus;hsa:3123,path:hsa05323,Rheumatoid arthritis;hsa:3123,path:hsa05320,Autoimmune thyroid disease;hsa:3123,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3123,path:hsa05330,Allograft rejection;hsa:3123,path:hsa05332,Graft-versus-host disease;hsa:3123,path:hsa05416,Viral myocarditis;hsa:3123,path:hsa04940,Type I diabetes mellitus;hsa:3123,path:hsa05150,Staphylococcus aureus infection;hsa:3123,path:hsa05152,Tuberculosis;hsa:3123,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3123,path:hsa05164,Influenza A;hsa:3123,path:hsa05168,Herpes simplex virus 1 infection;hsa:3123,path:hsa05169,Epstein-Barr virus infection;hsa:3123,path:hsa05145,Toxoplasmosis;hsa:3123,path:hsa05140,Leishmaniasis;hsa:3111,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3111,path:hsa04145,Phagosome;hsa:3111,path:hsa04640,Hematopoietic cell lineage;hsa:3111,path:hsa04612,Antigen processing and presentation;hsa:3111,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3111,path:hsa04659,Th17 cell differentiation;hsa:3111,path:hsa04672,Intestinal immune network for IgA production;hsa:3111,path:hsa05310,Asthma;hsa:3111,path:hsa05322,Systemic lupus erythematosus;hsa:3111,path:hsa05323,Rheumatoid arthritis;hsa:3111,path:hsa05320,Autoimmune thyroid disease;hsa:3111,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3111,path:hsa05330,Allograft rejection;hsa:3111,path:hsa05332,Graft-versus-host disease;hsa:3111,path:hsa05416,Viral myocarditis;hsa:3111,path:hsa04940,Type I diabetes mellitus;hsa:3111,path:hsa05150,Staphylococcus aureus infection;hsa:3111,path:hsa05152,Tuberculosis;hsa:3111,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3111,path:hsa05164,Influenza A;hsa:3111,path:hsa05168,Herpes simplex virus 1 infection;hsa:3111,path:hsa05169,Epstein-Barr virus infection;hsa:3111,path:hsa05145,Toxoplasmosis;hsa:3111,path:hsa05140,Leishmaniasis;hsa:3112,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3112,path:hsa04145,Phagosome;hsa:3112,path:hsa04640,Hematopoietic cell lineage;hsa:3112,path:hsa04612,Antigen processing and presentation;hsa:3112,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3112,path:hsa04659,Th17 cell differentiation;hsa:3112,path:hsa04672,Intestinal immune network for IgA production;hsa:3112,path:hsa05310,Asthma;hsa:3112,path:hsa05322,Systemic lupus erythematosus;hsa:3112,path:hsa05323,Rheumatoid arthritis;hsa:3112,path:hsa05320,Autoimmune thyroid disease;hsa:3112,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3112,path:hsa05330,Allograft rejection;hsa:3112,path:hsa05332,Graft-versus-host disease;hsa:3112,path:hsa05416,Viral myocarditis;hsa:3112,path:hsa04940,Type I diabetes mellitus;hsa:3112,path:hsa05150,Staphylococcus aureus infection;hsa:3112,path:hsa05152,Tuberculosis;hsa:3112,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3112,path:hsa05164,Influenza A;hsa:3112,path:hsa05168,Herpes simplex virus 1 infection;hsa:3112,path:hsa05169,Epstein-Barr virus infection;hsa:3112,path:hsa05145,Toxoplasmosis;hsa:3112,path:hsa05140,Leishmaniasis;hsa:3105,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3105,path:hsa04144,Endocytosis;hsa:3105,path:hsa04145,Phagosome;hsa:3105,path:hsa04218,Cellular senescence;hsa:3105,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3105,path:hsa04612,Antigen processing and presentation;hsa:3105,path:hsa05203,Viral carcinogenesis;hsa:3105,path:hsa05320,Autoimmune thyroid disease;hsa:3105,path:hsa05330,Allograft rejection;hsa:3105,path:hsa05332,Graft-versus-host disease;hsa:3105,path:hsa05416,Viral myocarditis;hsa:3105,path:hsa04940,Type I diabetes mellitus;hsa:3105,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3105,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3105,path:hsa05168,Herpes simplex virus 1 infection;hsa:3105,path:hsa05163,Human cytomegalovirus infection;hsa:3105,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3105,path:hsa05169,Epstein-Barr virus infection;hsa:3105,path:hsa05165,Human papillomavirus infection;hsa:3134,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3134,path:hsa04144,Endocytosis;hsa:3134,path:hsa04145,Phagosome;hsa:3134,path:hsa04218,Cellular senescence;hsa:3134,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3134,path:hsa04612,Antigen processing and presentation;hsa:3134,path:hsa05203,Viral carcinogenesis;hsa:3134,path:hsa05320,Autoimmune thyroid disease;hsa:3134,path:hsa05330,Allograft rejection;hsa:3134,path:hsa05332,Graft-versus-host disease;hsa:3134,path:hsa05416,Viral myocarditis;hsa:3134,path:hsa04940,Type I diabetes mellitus;hsa:3134,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3134,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3134,path:hsa05168,Herpes simplex virus 1 infection;hsa:3134,path:hsa05163,Human cytomegalovirus infection;hsa:3134,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3134,path:hsa05169,Epstein-Barr virus infection;hsa:3134,path:hsa05165,Human papillomavirus infection;hsa:3119,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3119,path:hsa04145,Phagosome;hsa:3119,path:hsa04640,Hematopoietic cell lineage;hsa:3119,path:hsa04612,Antigen processing and presentation;hsa:3119,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3119,path:hsa04659,Th17 cell differentiation;hsa:3119,path:hsa04672,Intestinal immune network for IgA production;hsa:3119,path:hsa05310,Asthma;hsa:3119,path:hsa05322,Systemic lupus erythematosus;hsa:3119,path:hsa05323,Rheumatoid arthritis;hsa:3119,path:hsa05320,Autoimmune thyroid disease;hsa:3119,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3119,path:hsa05330,Allograft rejection;hsa:3119,path:hsa05332,Graft-versus-host disease;hsa:3119,path:hsa05416,Viral myocarditis;hsa:3119,path:hsa04940,Type I diabetes mellitus;hsa:3119,path:hsa05150,Staphylococcus aureus infection;hsa:3119,path:hsa05152,Tuberculosis;hsa:3119,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3119,path:hsa05164,Influenza A;hsa:3119,path:hsa05168,Herpes simplex virus 1 infection;hsa:3119,path:hsa05169,Epstein-Barr virus infection;hsa:3119,path:hsa05145,Toxoplasmosis;hsa:3119,path:hsa05140,Leishmaniasis;hsa:3113,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3113,path:hsa04145,Phagosome;hsa:3113,path:hsa04640,Hematopoietic cell lineage;hsa:3113,path:hsa04612,Antigen processing and presentation;hsa:3113,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3113,path:hsa04659,Th17 cell differentiation;hsa:3113,path:hsa04672,Intestinal immune network for IgA production;hsa:3113,path:hsa05310,Asthma;hsa:3113,path:hsa05322,Systemic lupus erythematosus;hsa:3113,path:hsa05323,Rheumatoid arthritis;hsa:3113,path:hsa05320,Autoimmune thyroid disease;hsa:3113,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3113,path:hsa05330,Allograft rejection;hsa:3113,path:hsa05332,Graft-versus-host disease;hsa:3113,path:hsa05416,Viral myocarditis;hsa:3113,path:hsa04940,Type I diabetes mellitus;hsa:3113,path:hsa05150,Staphylococcus aureus infection;hsa:3113,path:hsa05152,Tuberculosis;hsa:3113,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3113,path:hsa05164,Influenza A;hsa:3113,path:hsa05168,Herpes simplex virus 1 infection;hsa:3113,path:hsa05169,Epstein-Barr virus infection;hsa:3113,path:hsa05145,Toxoplasmosis;hsa:3113,path:hsa05140,Leishmaniasis;hsa:3125,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3125,path:hsa04145,Phagosome;hsa:3125,path:hsa04640,Hematopoietic cell lineage;hsa:3125,path:hsa04612,Antigen processing and presentation;hsa:3125,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3125,path:hsa04659,Th17 cell differentiation;hsa:3125,path:hsa04672,Intestinal immune network for IgA production;hsa:3125,path:hsa05310,Asthma;hsa:3125,path:hsa05322,Systemic lupus erythematosus;hsa:3125,path:hsa05323,Rheumatoid arthritis;hsa:3125,path:hsa05320,Autoimmune thyroid disease;hsa:3125,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3125,path:hsa05330,Allograft rejection;hsa:3125,path:hsa05332,Graft-versus-host disease;hsa:3125,path:hsa05416,Viral myocarditis;hsa:3125,path:hsa04940,Type I diabetes mellitus;hsa:3125,path:hsa05150,Staphylococcus aureus infection;hsa:3125,path:hsa05152,Tuberculosis;hsa:3125,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3125,path:hsa05164,Influenza A;hsa:3125,path:hsa05168,Herpes simplex virus 1 infection;hsa:3125,path:hsa05169,Epstein-Barr virus infection;hsa:3125,path:hsa05145,Toxoplasmosis;hsa:3125,path:hsa05140,Leishmaniasis;hsa:3126,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3126,path:hsa04145,Phagosome;hsa:3126,path:hsa04640,Hematopoietic cell lineage;hsa:3126,path:hsa04612,Antigen processing and presentation;hsa:3126,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3126,path:hsa04659,Th17 cell differentiation;hsa:3126,path:hsa04672,Intestinal immune network for IgA production;hsa:3126,path:hsa05310,Asthma;hsa:3126,path:hsa05322,Systemic lupus erythematosus;hsa:3126,path:hsa05323,Rheumatoid arthritis;hsa:3126,path:hsa05320,Autoimmune thyroid disease;hsa:3126,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3126,path:hsa05330,Allograft rejection;hsa:3126,path:hsa05332,Graft-versus-host disease;hsa:3126,path:hsa05416,Viral myocarditis;hsa:3126,path:hsa04940,Type I diabetes mellitus;hsa:3126,path:hsa05150,Staphylococcus aureus infection;hsa:3126,path:hsa05152,Tuberculosis;hsa:3126,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3126,path:hsa05164,Influenza A;hsa:3126,path:hsa05168,Herpes simplex virus 1 infection;hsa:3126,path:hsa05169,Epstein-Barr virus infection;hsa:3126,path:hsa05145,Toxoplasmosis;hsa:3126,path:hsa05140,Leishmaniasis;hsa:3107,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3107,path:hsa04144,Endocytosis;hsa:3107,path:hsa04145,Phagosome;hsa:3107,path:hsa04218,Cellular senescence;hsa:3107,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3107,path:hsa04612,Antigen processing and presentation;hsa:3107,path:hsa05203,Viral carcinogenesis;hsa:3107,path:hsa05320,Autoimmune thyroid disease;hsa:3107,path:hsa05330,Allograft rejection;hsa:3107,path:hsa05332,Graft-versus-host disease;hsa:3107,path:hsa05416,Viral myocarditis;hsa:3107,path:hsa04940,Type I diabetes mellitus;hsa:3107,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3107,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3107,path:hsa05168,Herpes simplex virus 1 infection;hsa:3107,path:hsa05163,Human cytomegalovirus infection;hsa:3107,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3107,path:hsa05169,Epstein-Barr virus infection;hsa:3107,path:hsa05165,Human papillomavirus infection;hsa:3135,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3135,path:hsa04144,Endocytosis;hsa:3135,path:hsa04145,Phagosome;hsa:3135,path:hsa04218,Cellular senescence;hsa:3135,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3135,path:hsa04612,Antigen processing and presentation;hsa:3135,path:hsa05203,Viral carcinogenesis;hsa:3135,path:hsa05320,Autoimmune thyroid disease;hsa:3135,path:hsa05330,Allograft rejection;hsa:3135,path:hsa05332,Graft-versus-host disease;hsa:3135,path:hsa05416,Viral myocarditis;hsa:3135,path:hsa04940,Type I diabetes mellitus;hsa:3135,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3135,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3135,path:hsa05168,Herpes simplex virus 1 infection;hsa:3135,path:hsa05163,Human cytomegalovirus infection;hsa:3135,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3135,path:hsa05169,Epstein-Barr virus infection;hsa:3135,path:hsa05165,Human papillomavirus infection;hsa:3127,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3127,path:hsa04145,Phagosome;hsa:3127,path:hsa04640,Hematopoietic cell lineage;hsa:3127,path:hsa04612,Antigen processing and presentation;hsa:3127,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3127,path:hsa04659,Th17 cell differentiation;hsa:3127,path:hsa04672,Intestinal immune network for IgA production;hsa:3127,path:hsa05310,Asthma;hsa:3127,path:hsa05322,Systemic lupus erythematosus;hsa:3127,path:hsa05323,Rheumatoid arthritis;hsa:3127,path:hsa05320,Autoimmune thyroid disease;hsa:3127,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3127,path:hsa05330,Allograft rejection;hsa:3127,path:hsa05332,Graft-versus-host disease;hsa:3127,path:hsa05416,Viral myocarditis;hsa:3127,path:hsa04940,Type I diabetes mellitus;hsa:3127,path:hsa05150,Staphylococcus aureus infection;hsa:3127,path:hsa05152,Tuberculosis;hsa:3127,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3127,path:hsa05164,Influenza A;hsa:3127,path:hsa05168,Herpes simplex virus 1 infection;hsa:3127,path:hsa05169,Epstein-Barr virus infection;hsa:3127,path:hsa05145,Toxoplasmosis;hsa:3127,path:hsa05140,Leishmaniasis;hsa:3118,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3118,path:hsa04145,Phagosome;hsa:3118,path:hsa04640,Hematopoietic cell lineage;hsa:3118,path:hsa04612,Antigen processing and presentation;hsa:3118,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3118,path:hsa04659,Th17 cell differentiation;hsa:3118,path:hsa04672,Intestinal immune network for IgA production;hsa:3118,path:hsa05310,Asthma;hsa:3118,path:hsa05322,Systemic lupus erythematosus;hsa:3118,path:hsa05323,Rheumatoid arthritis;hsa:3118,path:hsa05320,Autoimmune thyroid disease;hsa:3118,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3118,path:hsa05330,Allograft rejection;hsa:3118,path:hsa05332,Graft-versus-host disease;hsa:3118,path:hsa05416,Viral myocarditis;hsa:3118,path:hsa04940,Type I diabetes mellitus;hsa:3118,path:hsa05150,Staphylococcus aureus infection;hsa:3118,path:hsa05152,Tuberculosis;hsa:3118,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3118,path:hsa05164,Influenza A;hsa:3118,path:hsa05168,Herpes simplex virus 1 infection;hsa:3118,path:hsa05169,Epstein-Barr virus infection;hsa:3118,path:hsa05145,Toxoplasmosis;hsa:3118,path:hsa05140,Leishmaniasis;hsa:3117,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3117,path:hsa04145,Phagosome;hsa:3117,path:hsa04640,Hematopoietic cell lineage;hsa:3117,path:hsa04612,Antigen processing and presentation;hsa:3117,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3117,path:hsa04659,Th17 cell differentiation;hsa:3117,path:hsa04672,Intestinal immune network for IgA production;hsa:3117,path:hsa05310,Asthma;hsa:3117,path:hsa05322,Systemic lupus erythematosus;hsa:3117,path:hsa05323,Rheumatoid arthritis;hsa:3117,path:hsa05320,Autoimmune thyroid disease;hsa:3117,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3117,path:hsa05330,Allograft rejection;hsa:3117,path:hsa05332,Graft-versus-host disease;hsa:3117,path:hsa05416,Viral myocarditis;hsa:3117,path:hsa04940,Type I diabetes mellitus;hsa:3117,path:hsa05150,Staphylococcus aureus infection;hsa:3117,path:hsa05152,Tuberculosis;hsa:3117,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3117,path:hsa05164,Influenza A;hsa:3117,path:hsa05168,Herpes simplex virus 1 infection;hsa:3117,path:hsa05169,Epstein-Barr virus infection;hsa:3117,path:hsa05145,Toxoplasmosis;hsa:3117,path:hsa05140,Leishmaniasis
NQO1_HUMAN	P15559	NQO1	NAD(P)H dehydrogenase [quinone] 1	3.49886976	7.698334296	0.882430481	0.549856477	5.598602028	0.716143479	5.598602028	0.716143479	7.81770998713513	0.028644	1	0.127914696457864	0.028359	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0043025,neuronal cell body;GO:0045202,synapse	GO:0004128,cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0042802,identical protein binding;GO:0003955,NAD(P)H dehydrogenase (quinone) activity;GO:0050136,NADH dehydrogenase (quinone) activity;GO:0008753,NADPH dehydrogenase (quinone) activity;GO:0003723,RNA binding;GO:0004784,superoxide dismutase activity	GO:0007568,aging;GO:0045454,cell redox homeostasis;GO:0070301,cellular response to hydrogen peroxide;GO:0071248,cellular response to metal ion;GO:0006116,NADH oxidation;GO:0070995,NADPH oxidation;GO:0043066,negative regulation of apoptotic process;GO:0043086,negative regulation of catalytic activity;GO:0006809,nitric oxide biosynthetic process;GO:0043525,positive regulation of neuron apoptotic process;GO:0006521,regulation of cellular amino acid metabolic process;GO:0043279,response to alkaloid;GO:0014075,response to amine;GO:0009743,response to carbohydrate;GO:0042493,response to drug;GO:0051602,response to electrical stimulus;GO:0032355,response to estradiol;GO:0045471,response to ethanol;GO:1905395,response to flavonoid;GO:0009725,response to hormone;GO:1904880,response to hydrogen sulfide;GO:0002931,response to ischemia;GO:1904844,response to L-glutamine;GO:0007584,response to nutrient;GO:0006979,response to oxidative stress;GO:0033574,response to testosterone;GO:1904772,response to tetrachloromethane;GO:0009636,response to toxic substance;GO:0007271,synaptic transmission, cholinergic;GO:0006805,xenobiotic metabolic process	hsa:1728,path:hsa00130,Ubiquinone and other terpenoid-quinone biosynthesis;hsa:1728,path:hsa05200,Pathways in cancer;hsa:1728,path:hsa05225,Hepatocellular carcinoma;hsa:1728,path:hsa05418,Fluid shear stress and atherosclerosis
GCYB1_HUMAN	Q02153	GUCY1B1	Guanylate cyclase soluble subunit beta-1	0.021665084	0.064352763	0.173435295	0.082774246	0.0430089235	0.1281047705	0.0430089235	0.1281047705	0.335732411307821	0.086343	0	2.97856258829636	0.086625	0	GO:0008074,guanylate cyclase complex, soluble;GO:0048786,presynaptic active zone;GO:0098978,glutamatergic synapse;GO:0098831,presynaptic active zone cytoplasmic component;GO:0005737,cytoplasm	GO:0005525,GTP binding;GO:0004383,guanylate cyclase activity;GO:0020037,heme binding;GO:0046872,metal ion binding;GO:0038023,signaling receptor activity;GO:0004016,adenylate cyclase activity;GO:0047805,cytidylate cyclase activity;GO:0051879,Hsp90 protein binding;GO:0044877,protein-containing complex binding	GO:0008015,blood circulation;GO:0071732,cellular response to nitric oxide;GO:0006182,cGMP biosynthetic process;GO:0019934,cGMP-mediated signaling;GO:0007263,nitric oxide mediated signal transduction;GO:0038060,nitric oxide-cGMP-mediated signaling pathway;GO:0099555,trans-synaptic signaling by nitric oxide, modulating synaptic transmission;GO:0035556,intracellular signal transduction	hsa:2983,path:hsa00230,Purine metabolism;hsa:2983,path:hsa04022,cGMP-PKG signaling pathway;hsa:2983,path:hsa04540,Gap junction;hsa:2983,path:hsa04611,Platelet activation;hsa:2983,path:hsa04921,Oxytocin signaling pathway;hsa:2983,path:hsa04924,Renin secretion;hsa:2983,path:hsa04270,Vascular smooth muscle contraction;hsa:2983,path:hsa04970,Salivary secretion;hsa:2983,path:hsa04730,Long-term depression;hsa:2983,path:hsa04713,Circadian entrainment
PRDX4_HUMAN	Q13162	PRDX4	Peroxiredoxin-4	13.47201512	8.112784488	13.15674276	12.4560013	10.792399804	12.80637203	10.792399804	12.80637203	0.842736707844962	0.490572	0	1.18661023151251	0.490501	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005634,nucleus;GO:0034774,secretory granule lumen;GO:0005790,smooth endoplasmic reticulum	GO:0008379,thioredoxin peroxidase activity;GO:0016209,antioxidant activity;GO:0016491,oxidoreductase activity;GO:0004601,peroxidase activity;GO:0051920,peroxiredoxin activity	GO:0045454,cell redox homeostasis;GO:0030198,extracellular matrix organization;GO:0007252,I-kappaB phosphorylation;GO:0008584,male gonad development;GO:2000255,negative regulation of male germ cell proliferation;GO:0043312,neutrophil degranulation;GO:0018401,peptidyl-proline hydroxylation to 4-hydroxy-L-proline;GO:0022417,protein maturation by protein folding;GO:0072593,reactive oxygen species metabolic process;GO:0006979,response to oxidative stress;GO:0007283,spermatogenesis	
SC16A_HUMAN	O15027	SEC16A	Protein transport protein Sec16A	1.83813526	1.653340545	1.576390793	2.513300315	1.7457379025	2.044845554	1.7457379025	2.044845554	0.853726042578177	0.486218	0	1.17133594399919	0.486137	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0031090,organelle membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005737,cytoplasm		GO:0006914,autophagy;GO:0048208,COPII vesicle coating;GO:0007029,endoplasmic reticulum organization;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030,Golgi organization;GO:0043000,Golgi to plasma membrane CFTR protein transport;GO:0070863,positive regulation of protein exit from endoplasmic reticulum;GO:0032527,protein exit from endoplasmic reticulum;GO:0070973,protein localization to endoplasmic reticulum exit site;GO:0072659,protein localization to plasma membrane;GO:0050821,protein stabilization;GO:0034976,response to endoplasmic reticulum stress;GO:0021762,substantia nigra development;GO:0015031,protein transport	
SC22B_HUMAN	O75396	SEC22B	Vesicle-trafficking protein SEC22b	6.952463945	25.01044153	2.100224674	1.538292281	15.9814527375	1.8192584775	15.9814527375	1.8192584775	8.78459709554933	0.022783	1	0.113835613531626	0.022536	-1	GO:0030137,COPI-coated vesicle;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0042470,melanosome;GO:0030670,phagocytic vesicle membrane;GO:0031201,SNARE complex;GO:0008021,synaptic vesicle;GO:0030133,transport vesicle;GO:0005737,cytoplasm	GO:0005484,SNAP receptor activity;GO:0019905,syntaxin binding	GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:1902902,negative regulation of autophagosome assembly;GO:0045732,positive regulation of protein catabolic process;GO:0015031,protein transport;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:1990668,vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane;GO:0048280,vesicle fusion with Golgi apparatus	hsa:9554,path:hsa04130,SNARE interactions in vesicular transport;hsa:9554,path:hsa04145,Phagosome;hsa:9554,path:hsa05134,Legionellosis
NNRD_HUMAN	Q8IW45	NAXD	ATP-dependent (S)-NAD(P)H-hydrate dehydratase	0.140761922	0.12380569	0.10184846	0.118223916	0.132283806	0.110036188	0.132283806	0.110036188	1.20218455768388	0.373327	0	0.83181903611089	0.373007	0	GO:0005759,mitochondrial matrix	GO:0052855,ADP-dependent NAD(P)H-hydrate dehydratase activity;GO:0005524,ATP binding;GO:0047453,ATP-dependent NAD(P)H-hydrate dehydratase activity	GO:0110051,metabolite repair;GO:0034356,NAD biosynthesis via nicotinamide riboside salvage pathway	
SUV3_HUMAN	Q8IYB8	SUPV3L1	ATP-dependent RNA helicase SUPV3L1, mitochondrial	0.122035591	0.06374686	0.148894851	2.55E-05	0.0928912255	0.0744601755	0.0928912255	0.0744601755	1.24752896264662	0.361572	0	0.801584596383649	0.361229	0	GO:0045025,mitochondrial degradosome;GO:0005759,mitochondrial matrix;GO:0042645,mitochondrial nucleoid;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0034458,3'-5' RNA helicase activity;GO:0005524,ATP binding;GO:0003677,DNA binding;GO:0003678,DNA helicase activity;GO:0003725,double-stranded RNA binding;GO:0004386,helicase activity;GO:0042803,protein homodimerization activity;GO:0003723,RNA binding;GO:0003724,RNA helicase activity	GO:0070827,chromatin maintenance;GO:0032508,DNA duplex unwinding;GO:0006310,DNA recombination;GO:0000958,mitochondrial mRNA catabolic process;GO:0035946,mitochondrial mRNA surveillance;GO:0035945,mitochondrial ncRNA surveillance;GO:0000965,mitochondrial RNA 3'-end processing;GO:2000827,mitochondrial RNA surveillance;GO:0070584,mitochondrion morphogenesis;GO:0043066,negative regulation of apoptotic process;GO:0030307,positive regulation of cell growth;GO:0000962,positive regulation of mitochondrial RNA catabolic process;GO:0006401,RNA catabolic process	
HMHA1_HUMAN	Q92619	ARHGAP45	Rho GTPase-activating protein 45	0.14691958	0.082758591	0.424858411	0.272657653	0.1148390855	0.348758032	0.1148390855	0.348758032	0.329280116765884	0.081767	0	3.03692798041308	0.082044	0	GO:0035578,azurophil granule lumen;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0016020,membrane;GO:0032587,ruffle membrane;GO:0034774,secretory granule lumen	GO:0005096,GTPase activator activity;GO:0046872,metal ion binding	GO:0090630,activation of GTPase activity;GO:0035556,intracellular signal transduction;GO:0043312,neutrophil degranulation;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0043547,positive regulation of GTPase activity;GO:0007165,signal transduction	
AHSA1_HUMAN	O95433	AHSA1	Activator of 90 kDa heat shock protein ATPase homolog 1	19.95250434	18.39933333	23.54418705	43.29226069	19.175918835	33.41822387	19.175918835	33.41822387	0.573816218049053	0.293045	0	1.74271825812095	0.293338	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome	GO:0001671,ATPase activator activity;GO:0045296,cadherin binding;GO:0051087,chaperone binding;GO:0051879,Hsp90 protein binding	GO:0032781,positive regulation of ATPase activity;GO:0006457,protein folding;GO:0016032,viral process	
IF5A1_HUMAN	P63241	EIF5A	Eukaryotic translation initiation factor 5A-1	4.167509708	8.037210295	0.655128542	0.884706466	6.1023600015	0.769917504	6.1023600015	0.769917504	7.92599203134886	0.027893	1	0.126167172013901	0.027613	-1	GO:0005642,annulate lamellae;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0016020,membrane;GO:0005643,nuclear pore;GO:0005634,nucleus	GO:0047485,protein N-terminus binding;GO:0043022,ribosome binding;GO:0003723,RNA binding;GO:0003746,translation elongation factor activity;GO:0017070,U6 snRNA binding	GO:0006915,apoptotic process;GO:0006406,mRNA export from nucleus;GO:0006913,nucleocytoplasmic transport;GO:0008284,positive regulation of cell population proliferation;GO:0045901,positive regulation of translational elongation;GO:0045905,positive regulation of translational termination;GO:0006611,protein export from nucleus;GO:0051028,mRNA transport;GO:0015031,protein transport	
TPM1_HUMAN	P09493	TPM1	Tropomyosin alpha-1 chain	2.025199695	1.110480305	0.914777489	1.686070716	1.56784	1.3004241025	1.56784	1.3004241025	1.20563745087922	0.372412	0	0.82943674258853	0.372090	0	GO:0015629,actin cytoskeleton;GO:0005884,actin filament;GO:0032059,bleb;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005862,muscle thin filament tropomyosin;GO:0032587,ruffle membrane;GO:0030017,sarcomere;GO:0001725,stress fiber;GO:0016021,integral component of membrane	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0008092,cytoskeletal protein binding;GO:0042802,identical protein binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0005200,structural constituent of cytoskeleton;GO:0008307,structural constituent of muscle	GO:0007015,actin filament organization;GO:0060048,cardiac muscle contraction;GO:0034614,cellular response to reactive oxygen species;GO:0007010,cytoskeleton organization;GO:0006936,muscle contraction;GO:0030049,muscle filament sliding;GO:0030336,negative regulation of cell migration;GO:1904753,negative regulation of vascular associated smooth muscle cell migration;GO:1904706,negative regulation of vascular associated smooth muscle cell proliferation;GO:0032781,positive regulation of ATPase activity;GO:0045785,positive regulation of cell adhesion;GO:0003065,positive regulation of heart rate by epinephrine;GO:0051496,positive regulation of stress fiber assembly;GO:0008360,regulation of cell shape;GO:0008016,regulation of heart contraction;GO:0006937,regulation of muscle contraction;GO:0031529,ruffle organization;GO:0045214,sarcomere organization;GO:0055010,ventricular cardiac muscle tissue morphogenesis;GO:0042060,wound healing	hsa:7168,path:hsa04260,Cardiac muscle contraction;hsa:7168,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:7168,path:hsa05206,MicroRNAs in cancer;hsa:7168,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:7168,path:hsa05414,Dilated cardiomyopathy (DCM)
XRCC6_HUMAN	P12956	XRCC6	X-ray repair cross-complementing protein 6	23.37199641	17.43447465	24.54998072	13.63345855	20.40323553	19.091719635	20.40323553	19.091719635	1.06869553503162	0.411438	0	0.935720200206893	0.411195	0	GO:0000781,chromosome, telomeric region;GO:0005829,cytosol;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0043564,Ku70;GO:0016020,membrane;GO:0070419,nonhomologous end joining complex;GO:0000783,nuclear telomere cap complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0032993,protein-DNA complex;GO:0034774,secretory granule lumen;GO:0005667,transcription regulator complex	GO:0051575,5'-deoxyribose-5-phosphate lyase activity;GO:0005524,ATP binding;GO:0008094,ATPase activity, acting on DNA;GO:0030332,cyclin binding;GO:0003684,damaged DNA binding;GO:0003677,DNA binding;GO:0003678,DNA helicase activity;GO:0003690,double-stranded DNA binding;GO:0008022,protein C-terminus binding;GO:0044877,protein-containing complex binding;GO:0003723,RNA binding;GO:0042162,telomeric DNA binding;GO:0000976,transcription regulatory region sequence-specific DNA binding;GO:0016787,hydrolase activity	GO:0002218,activation of innate immune response;GO:0007420,brain development;GO:0071475,cellular hyperosmotic salinity response;GO:0071480,cellular response to gamma radiation;GO:0071481,cellular response to X-ray;GO:0006266,DNA ligation;GO:0006310,DNA recombination;GO:0097680,double-strand break repair via classical nonhomologous end joining;GO:0006303,double-strand break repair via nonhomologous end joining;GO:0075713,establishment of integrated proviral latency;GO:0045087,innate immune response;GO:0045892,negative regulation of transcription, DNA-templated;GO:0043312,neutrophil degranulation;GO:0045621,positive regulation of lymphocyte differentiation;GO:0045860,positive regulation of protein kinase activity;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0032481,positive regulation of type I interferon production;GO:0048660,regulation of smooth muscle cell proliferation;GO:0000723,telomere maintenance;GO:0016032,viral process	hsa:2547,path:hsa03450,Non-homologous end-joining
SC24C_HUMAN	P53992	SEC24C	Protein transport protein Sec24C	1.672519794	1.712400087	2.284119386	2.07870677	1.6924599405	2.181413078	1.6924599405	2.181413078	0.775854861038841	0.466721	0	1.28890086305709	0.466849	0	GO:0030127,COPII vesicle coat;GO:0005829,cytosol;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0012507,ER to Golgi transport vesicle membrane	GO:0000149,SNARE binding;GO:0008270,zinc ion binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0048208,COPII vesicle coating;GO:0090110,COPII-coated vesicle cargo loading;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport	hsa:9632,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:9632,path:hsa05130,Pathogenic Escherichia coli infection
HNRPF_HUMAN	P52597	HNRNPF	Heterogeneous nuclear ribonucleoprotein F	12.17073057	12.3068241	16.40605646	9.564653	12.238777335	12.98535473	12.238777335	12.98535473	0.942506199443656	0.453057	0	1.06100097865699	0.452903	0	GO:0071013,catalytic step 2 spliceosome;GO:0005829,cytosol;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:1990904,ribonucleoprotein complex	GO:0003723,RNA binding;GO:0003727,single-stranded RNA binding;GO:0017025,TBP-class protein binding;GO:0003676,nucleic acid binding	GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0035722,interleukin-12-mediated signaling pathway;GO:0000398,mRNA splicing, via spliceosome;GO:0043484,regulation of RNA splicing;GO:0016070,RNA metabolic process;GO:0006396,RNA processing	
EXOC1_HUMAN	Q9NV70	EXOC1	Exocyst complex component 1	0.034148642	0.060131395	0.101256613	2.55E-05	0.0471400185	0.0506410565	0.0471400185	0.0506410565	0.930865620862393	0.457210	0	1.07426891442565	0.457065	0	GO:0005737,cytoplasm;GO:0098592,cytoplasmic side of apical plasma membrane;GO:0005829,cytosol;GO:0000145,exocyst;GO:0090543,Flemming body;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane	GO:0005546,phosphatidylinositol-4,5-bisphosphate binding	GO:0060271,cilium assembly;GO:0051607,defense response to virus;GO:0006887,exocytosis;GO:0006893,Golgi to plasma membrane transport;GO:0048015,phosphatidylinositol-mediated signaling;GO:0050714,positive regulation of protein secretion;GO:0015031,protein transport;GO:0016241,regulation of macroautophagy;GO:0016032,viral process	
8ODP_HUMAN	P36639	NUDT1	7,8-dihydro-8-oxoguanine triphosphatase	0.199198008	2.55E-05	0.022541501	2.55E-05	0.099611754	0.0112835005	0.099611754	0.0112835005	8.82808965178847	0.022559	1	0.113274789840564	0.022314	-1	GO:0001669,acrosomal vesicle;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005615,extracellular space;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0031965,nuclear membrane;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0035539,8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity;GO:0008413,8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity;GO:0047693,ATP diphosphatase activity;GO:0008828,dATP pyrophosphohydrolase activity;GO:0046872,metal ion binding;GO:0030515,snoRNA binding	GO:0007568,aging;GO:0042262,DNA protection;GO:0006281,DNA repair;GO:0008584,male gonad development;GO:0034656,nucleobase-containing small molecule catabolic process;GO:0046686,response to cadmium ion;GO:0006979,response to oxidative stress	
PPIA_HUMAN	P62937	PPIA	Peptidyl-prolyl cis-trans isomerase A	122.0180764	269.0785462	14.53776441	9.253814361	195.5483113	11.8957893855	195.5483113	11.8957893855	16.4384476694214	0.005743	1	0.0608329947030333	0.005649	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0005925,focal adhesion;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0034774,secretory granule lumen;GO:0031982,vesicle	GO:0016018,cyclosporin A binding;GO:1904399,heparan sulfate binding;GO:0005178,integrin binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity;GO:0003723,RNA binding;GO:0051082,unfolded protein binding;GO:0046790,virion binding	GO:0000187,activation of MAPK activity;GO:0032148,activation of protein kinase B activity;GO:0006915,apoptotic process;GO:0060352,cell adhesion molecule production;GO:0034599,cellular response to oxidative stress;GO:0042118,endothelial cell activation;GO:0044409,entry into host;GO:0075713,establishment of integrated proviral latency;GO:0019064,fusion of virus membrane with host plasma membrane;GO:0035722,interleukin-12-mediated signaling pathway;GO:0030595,leukocyte chemotaxis;GO:0050900,leukocyte migration;GO:0034389,lipid droplet organization;GO:1902176,negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:0061944,negative regulation of protein K48-linked ubiquitination;GO:0006469,negative regulation of protein kinase activity;GO:0001933,negative regulation of protein phosphorylation;GO:0032873,negative regulation of stress-activated MAPK cascade;GO:1903901,negative regulation of viral life cycle;GO:0030593,neutrophil chemotaxis;GO:0043312,neutrophil degranulation;GO:0030168,platelet activation;GO:0070527,platelet aggregation;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0035307,positive regulation of protein dephosphorylation;GO:0001934,positive regulation of protein phosphorylation;GO:0050714,positive regulation of protein secretion;GO:0045070,positive regulation of viral genome replication;GO:0006457,protein folding;GO:0000413,protein peptidyl-prolyl isomerization;GO:2001233,regulation of apoptotic signaling pathway;GO:0045069,regulation of viral genome replication;GO:0006278,RNA-dependent DNA biosynthetic process;GO:0019061,uncoating of virus;GO:0019058,viral life cycle;GO:0019076,viral release from host cell;GO:0019068,virion assembly	hsa:5478,path:hsa04217,Necroptosis
ITAM_HUMAN	P11215	ITGAM	Integrin alpha-M	1.115706035	1.731287755	1.258942026	2.064027821	1.423496895	1.6614849235	1.423496895	1.6614849235	0.856761848913641	0.485025	0	1.16718549182364	0.484941	0	GO:0009986,cell surface;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0034688,integrin alphaM-beta2 complex;GO:0008305,integrin complex;GO:0005886,plasma membrane;GO:0044853,plasma membrane raft;GO:0035579,specific granule membrane;GO:0070821,tertiary granule membrane;GO:0016021,integral component of membrane	GO:0001540,amyloid-beta binding;GO:0038024,cargo receptor activity;GO:0001851,complement component C3b binding;GO:0031072,heat shock protein binding;GO:0005178,integrin binding;GO:0046872,metal ion binding	GO:0097242,amyloid-beta clearance;GO:0097190,apoptotic signaling pathway;GO:0007155,cell adhesion;GO:1905114,cell surface receptor signaling pathway involved in cell-cell signaling;GO:0098742,cell-cell adhesion via plasma-membrane adhesion molecules;GO:0150062,complement-mediated synapse pruning;GO:0019221,cytokine-mediated signaling pathway;GO:0010668,ectodermal cell differentiation;GO:0030198,extracellular matrix organization;GO:0030900,forebrain development;GO:0045087,innate immune response;GO:0007229,integrin-mediated signaling pathway;GO:0050900,leukocyte migration;GO:0001774,microglial cell activation;GO:0045963,negative regulation of dopamine metabolic process;GO:0043312,neutrophil degranulation;GO:0006911,phagocytosis, engulfment;GO:0110090,positive regulation of hippocampal neuron apoptotic process;GO:1904151,positive regulation of microglial cell mediated cytotoxicity;GO:1901216,positive regulation of neuron death;GO:0043315,positive regulation of neutrophil degranulation;GO:2000363,positive regulation of prostaglandin-E synthase activity;GO:0090314,positive regulation of protein targeting to membrane;GO:0032930,positive regulation of superoxide anion generation;GO:0006898,receptor-mediated endocytosis;GO:0034142,toll-like receptor 4 signaling pathway;GO:0150064,vertebrate eye-specific patterning	hsa:3684,path:hsa04015,Rap1 signaling pathway;hsa:3684,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3684,path:hsa04145,Phagosome;hsa:3684,path:hsa04810,Regulation of actin cytoskeleton;hsa:3684,path:hsa04640,Hematopoietic cell lineage;hsa:3684,path:hsa04610,Complement and coagulation cascades;hsa:3684,path:hsa04670,Leukocyte transendothelial migration;hsa:3684,path:hsa05202,Transcriptional misregulation in cancer;hsa:3684,path:hsa05221,Acute myeloid leukemia;hsa:3684,path:hsa05133,Pertussis;hsa:3684,path:hsa05134,Legionellosis;hsa:3684,path:hsa05150,Staphylococcus aureus infection;hsa:3684,path:hsa05152,Tuberculosis;hsa:3684,path:hsa05146,Amoebiasis;hsa:3684,path:hsa05140,Leishmaniasis
RL32_HUMAN	P62910	RPL32	60S ribosomal protein L32	0.614649554	0.338949362	0.008929587	0.06107831	0.476799458	0.0350039485	0.476799458	0.0350039485	13.6213049793511	0.008916	1	0.0734144049719117	0.008786	-1	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0016020,membrane;GO:0042788,polysomal ribosome;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6161,path:hsa03010,Ribosome
PGM1_HUMAN	P36871	PGM1	Phosphoglucomutase-1	6.64999044	7.852024327	8.947901469	9.42692634	7.2510073835	9.1874139045	7.2510073835	9.1874139045	0.789232689293388	0.477118	0	1.26705344769147	0.477234	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:1904724,tertiary granule lumen	GO:0000287,magnesium ion binding;GO:0004614,phosphoglucomutase activity;GO:0016868,intramolecular transferase activity, phosphotransferases	GO:0005975,carbohydrate metabolic process;GO:0006094,gluconeogenesis;GO:0006006,glucose metabolic process;GO:0005978,glycogen biosynthetic process;GO:0006096,glycolytic process;GO:0043312,neutrophil degranulation	hsa:5236,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:5236,path:hsa00030,Pentose phosphate pathway;hsa:5236,path:hsa00052,Galactose metabolism;hsa:5236,path:hsa00500,Starch and sucrose metabolism;hsa:5236,path:hsa00520,Amino sugar and nucleotide sugar metabolism;hsa:5236,path:hsa00230,Purine metabolism
RAI14_HUMAN	Q9P0K7	RAI14	Ankycorbin	1.845276791	1.416696279	1.827229341	9.416876494	1.630986535	5.6220529175	1.630986535	5.6220529175	0.29010515534693	0.056273	0	3.44702595444787	0.056505	0	GO:0005938,cell cortex;GO:0030054,cell junction;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0001650,fibrillar center;GO:0005654,nucleoplasm	GO:0003779,actin binding	GO:0030154,cell differentiation;GO:0007283,spermatogenesis;GO:0097190,apoptotic signaling pathway;GO:1901222,regulation of NIK/NF-kappaB signaling	
TF3C2_HUMAN	Q8WUA4	GTF3C2	General transcription factor 3C polypeptide 2	0.011279804	0.036829996	0.026796835	2.55E-05	0.0240549	0.0134111675	0.0240549	0.0134111675	1.79364697368816	0.254533	0	0.557523311258829	0.254020	0	GO:0005654,nucleoplasm;GO:0000127,transcription factor TFIIIC complex		GO:0042791,5S class rRNA transcription by RNA polymerase III;GO:0006383,transcription by RNA polymerase III;GO:0042797,tRNA transcription by RNA polymerase III	
CYTA_HUMAN	P01040	CSTA	Cystatin-A	1.06208609	1.688932607	0.648581354	1.271060732	1.3755093485	0.959821043	1.3755093485	0.959821043	1.43308938528867	0.318771	0	0.697793180429264	0.318351	0	GO:0001533,cornified envelope;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005615,extracellular space;GO:0005654,nucleoplasm	GO:0004869,cysteine-type endopeptidase inhibitor activity;GO:0002020,protease binding	GO:0098609,cell-cell adhesion;GO:0070268,cornification;GO:0030216,keratinocyte differentiation;GO:0010466,negative regulation of peptidase activity;GO:0045861,negative regulation of proteolysis;GO:0018149,peptide cross-linking	
RB11B_HUMAN	Q15907	RAB11B	Ras-related protein Rab-11B	12.12351802	63.82884369	3.332167957	1.8923334	37.976180855	2.6122506785	37.976180855	2.6122506785	14.5377245635578	0.007676	1	0.0687865556695669	0.007559	-1	GO:0098993,anchored component of synaptic vesicle membrane;GO:0005829,cytosol;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0045335,phagocytic vesicle;GO:0030670,phagocytic vesicle membrane;GO:0055037,recycling endosome;GO:0055038,recycling endosome membrane;GO:0008021,synaptic vesicle	GO:0045296,cadherin binding;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0031489,myosin V binding	GO:0150093,amyloid-beta clearance by transcytosis;GO:0071468,cellular response to acidic pH;GO:0045054,constitutive secretory pathway;GO:0032456,endocytic recycling;GO:0090150,establishment of protein localization to membrane;GO:0006887,exocytosis;GO:0035773,insulin secretion involved in cellular response to glucose stimulus;GO:0032402,melanosome transport;GO:0043687,post-translational protein modification;GO:0001881,receptor recycling;GO:0045055,regulated exocytosis;GO:0044070,regulation of anion transport;GO:2001135,regulation of endocytic recycling;GO:2000008,regulation of protein localization to cell surface;GO:0033572,transferrin transport	hsa:9230,path:hsa04152,AMPK signaling pathway;hsa:9230,path:hsa04144,Endocytosis;hsa:9230,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:9230,path:hsa05164,Influenza A
VP33B_HUMAN	Q9H267	VPS33B	Vacuolar protein sorting-associated protein 33B	0.132030909	0.123267858	0.211757803	0.1956087	0.1276493835	0.2036832515	0.1276493835	0.2036832515	0.626705350390579	0.340986	0	1.59564618265469	0.341243	0	GO:0030136,clathrin-coated vesicle;GO:0033263,CORVET complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0005794,Golgi apparatus;GO:0030897,HOPS complex;GO:0005770,late endosome;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0048471,perinuclear region of cytoplasm;GO:0031091,platelet alpha granule;GO:0055037,recycling endosome	GO:0044877,protein-containing complex binding	GO:0032963,collagen metabolic process;GO:0007032,endosome organization;GO:0006886,intracellular protein transport;GO:0032418,lysosome localization;GO:0032400,melanosome localization;GO:0061025,membrane fusion;GO:0017185,peptidyl-lysine hydroxylation;GO:0070889,platelet alpha granule organization;GO:0015031,protein transport;GO:0016192,vesicle-mediated transport	
NDUF4_HUMAN	Q9P032	NDUFAF4	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4	0.402458625	0.992615276	0.020929223	2.55E-05	0.6975369505	0.0104773615	0.6975369505	0.0104773615	66.5756307539832	0.000105	1	0.0150205110890394	0.000102	-1	GO:0005743,mitochondrial inner membrane;GO:0031966,mitochondrial membrane;GO:0005739,mitochondrion	GO:0005516,calmodulin binding	GO:0032981,mitochondrial respiratory chain complex I assembly	hsa:29078,path:hsa04714,Thermogenesis
FUCO2_HUMAN	Q9BTY2	FUCA2	Plasma alpha-L-fucosidase	0.030571729	0.252175061	0.145985631	2.55E-05	0.141373395	0.0730055655	0.141373395	0.0730055655	1.93647421305161	0.234266	0	0.516402435550197	0.233731	0	GO:0035578,azurophil granule lumen;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005764,lysosome	GO:0004560,alpha-L-fucosidase activity	GO:0044267,cellular protein metabolic process;GO:0006004,fucose metabolic process;GO:0016139,glycoside catabolic process;GO:0043312,neutrophil degranulation;GO:0043687,post-translational protein modification;GO:2000535,regulation of entry of bacterium into host cell;GO:0009617,response to bacterium;GO:0005975,carbohydrate metabolic process	hsa:2519,path:hsa00511,Other glycan degradation
ACLY_HUMAN	P53396	ACLY	ATP-citrate synthase	22.32239781	23.88116934	21.41403416	42.43332775	23.101783575	31.923680955	23.101783575	31.923680955	0.723656636199458	0.424673	0	1.38187083483661	0.424847	0	GO:0035578,azurophil granule lumen;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0005524,ATP binding;GO:0003878,ATP citrate synthase activity;GO:0046872,metal ion binding	GO:0006085,acetyl-CoA biosynthetic process;GO:0006695,cholesterol biosynthetic process;GO:0006101,citrate metabolic process;GO:0015936,coenzyme A metabolic process;GO:0006633,fatty acid biosynthetic process;GO:0046949,fatty-acyl-CoA biosynthetic process;GO:0008610,lipid biosynthetic process;GO:0043312,neutrophil degranulation;GO:0006107,oxaloacetate metabolic process;GO:0031325,positive regulation of cellular metabolic process	hsa:47,path:hsa00020,Citrate cycle (TCA cycle)
THIL_HUMAN	P24752	ACAT1	Acetyl-CoA acetyltransferase, mitochondrial	4.385286389	4.405409024	9.993061654	5.65379469	4.3953477065	7.823428172	4.3953477065	7.823428172	0.561818631150845	0.282036	0	1.77993385151997	0.282337	0	GO:0070062,extracellular exosome;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0003985,acetyl-CoA C-acetyltransferase activity;GO:0016453,C-acetyltransferase activity;GO:0030955,potassium ion binding;GO:0016747,transferase activity, transferring acyl groups other than amino-acyl groups;GO:0120225,coenzyme A binding;GO:0019899,enzyme binding;GO:0042802,identical protein binding	GO:0006085,acetyl-CoA biosynthetic process;GO:0046356,acetyl-CoA catabolic process;GO:0009083,branched-chain amino acid catabolic process;GO:0034435,cholesterol esterification;GO:0015937,coenzyme A biosynthetic process;GO:0015936,coenzyme A metabolic process;GO:0006635,fatty acid beta-oxidation;GO:0006550,isoleucine catabolic process;GO:0046951,ketone body biosynthetic process;GO:0046952,ketone body catabolic process;GO:1902224,ketone body metabolic process;GO:1902860,propionyl-CoA biosynthetic process;GO:0060612,adipose tissue development;GO:0007420,brain development;GO:0001889,liver development;GO:0072229,metanephric proximal convoluted tubule development;GO:0009725,response to hormone;GO:0014070,response to organic cyclic compound;GO:0042594,response to starvation	hsa:38,path:hsa00620,Pyruvate metabolism;hsa:38,path:hsa00630,Glyoxylate and dicarboxylate metabolism;hsa:38,path:hsa00640,Propanoate metabolism;hsa:38,path:hsa00650,Butanoate metabolism;hsa:38,path:hsa00071,Fatty acid degradation;hsa:38,path:hsa00072,Synthesis and degradation of ketone bodies;hsa:38,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:38,path:hsa00310,Lysine degradation;hsa:38,path:hsa00380,Tryptophan metabolism;hsa:38,path:hsa00900,Terpenoid backbone biosynthesis
RAB7L_HUMAN	O14966	RAB29	Ras-related protein Rab-7L1	0.050017396	0.125199731	0.018547296	0.008000165	0.0876085635	0.0132737305	0.0876085635	0.0132737305	6.60014631907737	0.039339	1	0.151511792565803	0.038996	-1	GO:0005801,cis-Golgi network;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005769,early endosome;GO:0012505,endomembrane system;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0097708,intracellular vesicle;GO:0042470,melanosome;GO:0005739,mitochondrion;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0055037,recycling endosome;GO:0005802,trans-Golgi network;GO:0005773,vacuole	GO:0070840,dynein complex binding;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0019894,kinesin binding;GO:0031267,small GTPase binding	GO:0030154,cell differentiation;GO:0007030,Golgi organization;GO:0006886,intracellular protein transport;GO:0032438,melanosome organization;GO:0007005,mitochondrion organization;GO:0010977,negative regulation of neuron projection development;GO:0090316,positive regulation of intracellular protein transport;GO:0001921,positive regulation of receptor recycling;GO:0050862,positive regulation of T cell receptor signaling pathway;GO:1903441,protein localization to ciliary membrane;GO:0072657,protein localization to membrane;GO:1901214,regulation of neuron death;GO:1905279,regulation of retrograde transport, endosome to Golgi;GO:0009617,response to bacterium;GO:0042147,retrograde transport, endosome to Golgi;GO:0007416,synapse assembly;GO:0042110,T cell activation;GO:1901998,toxin transport;GO:0039694,viral RNA genome replication	
APT_HUMAN	P07741	APRT	Adenine phosphoribosyltransferase	8.331350331	20.71128712	1.652581018	0.355670118	14.5213187255	1.004125568	14.5213187255	1.004125568	14.4616561795387	0.007770	1	0.0691483732973037	0.007652	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005654,nucleoplasm;GO:0034774,secretory granule lumen	GO:0002055,adenine binding;GO:0003999,adenine phosphoribosyltransferase activity;GO:0016208,AMP binding	GO:0006168,adenine salvage;GO:0044209,AMP salvage;GO:0032869,cellular response to insulin stimulus;GO:0007625,grooming behavior;GO:0007595,lactation;GO:0043312,neutrophil degranulation;GO:0006166,purine ribonucleoside salvage;GO:0043101,purine-containing compound salvage;GO:0009116,nucleoside metabolic process	hsa:353,path:hsa00230,Purine metabolism
FHL3_HUMAN	Q13643	FHL3	Four and a half LIM domains protein 3	0.403626312	0.566817603	0.186213164	2.55E-05	0.4852219575	0.093119332	0.4852219575	0.093119332	5.21075427710328	0.059476	0	0.191910795792872	0.059051	0	GO:0005925,focal adhesion;GO:0005634,nucleus;GO:0001725,stress fiber;GO:0030018,Z disc	GO:0003779,actin binding;GO:0046872,metal ion binding;GO:0003712,transcription coregulator activity	GO:0030036,actin cytoskeleton organization;GO:0007517,muscle organ development	
DIC_HUMAN	Q9UBX3	SLC25A10	Mitochondrial dicarboxylate carrier	0.339323828	0.470364097	0.237250803	0.159990788	0.4048439625	0.1986207955	0.4048439625	0.1986207955	2.03827580833549	0.221227	0	0.490610738699111	0.220681	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0015297,antiporter activity;GO:0005310,dicarboxylic acid transmembrane transporter activity;GO:0015140,malate transmembrane transporter activity;GO:0015131,oxaloacetate transmembrane transporter activity;GO:0015141,succinate transmembrane transporter activity;GO:0015116,sulfate transmembrane transporter activity;GO:0015117,thiosulfate transmembrane transporter activity	GO:0006835,dicarboxylic acid transport;GO:0006094,gluconeogenesis;GO:0006811,ion transport;GO:0071423,malate transmembrane transport;GO:0006839,mitochondrial transport;GO:0015729,oxaloacetate transport;GO:0035435,phosphate ion transmembrane transport;GO:0071422,succinate transmembrane transport;GO:0008272,sulfate transport;GO:0070221,sulfide oxidation, using sulfide;GO:0015709,thiosulfate transport	hsa:1468,path:hsa04964,Proximal tubule bicarbonate reclamation
PTPRE_HUMAN	P23469	PTPRE	Receptor-type tyrosine-protein phosphatase epsilon	0.370570058	0.099267217	0.308874475	0.276346628	0.2349186375	0.2926105515	0.2349186375	0.2926105515	0.802837205615943	0.487527	0	1.24558253280351	0.487632	0	GO:0005737,cytoplasm;GO:0016021,integral component of membrane;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0004725,protein tyrosine phosphatase activity;GO:0005001,transmembrane receptor protein tyrosine phosphatase activity	GO:0046627,negative regulation of insulin receptor signaling pathway;GO:0006470,protein dephosphorylation	
PDLI1_HUMAN	O00151	PDLIM1	PDZ and LIM domain protein 1	3.112400096	3.120398152	4.763966617	3.451320166	3.116399124	4.1076433915	3.116399124	4.1076433915	0.758682978772891	0.453145	0	1.31807359329113	0.453289	0	GO:0005912,adherens junction;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0031941,filamentous actin;GO:0005925,focal adhesion;GO:0001725,stress fiber;GO:0005667,transcription regulator complex;GO:0030018,Z disc	GO:0003779,actin binding;GO:0098641,cadherin binding involved in cell-cell adhesion;GO:0046872,metal ion binding;GO:0051371,muscle alpha-actinin binding;GO:0003713,transcription coactivator activity	GO:0030036,actin cytoskeleton organization;GO:0030950,establishment or maintenance of actin cytoskeleton polarity;GO:0010761,fibroblast migration;GO:0007507,heart development;GO:0030011,maintenance of cell polarity;GO:0061061,muscle structure development;GO:0006357,regulation of transcription by RNA polymerase II;GO:0001666,response to hypoxia;GO:0006979,response to oxidative stress;GO:0043149,stress fiber assembly	
CLC4K_HUMAN	Q9UJ71	CD207	C-type lectin domain family 4 member K	1.606443147	2.648841061	1.848053667	1.533432314	2.127642104	1.6907429905	2.127642104	1.6907429905	1.25840657980241	0.358834	0	0.794655730548562	0.358485	0	GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0031901,early endosome membrane;GO:0030139,endocytic vesicle;GO:0016021,integral component of membrane;GO:0005886,plasma membrane	GO:0030246,carbohydrate binding;GO:0005537,mannose binding	GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0051607,defense response to virus;GO:0006898,receptor-mediated endocytosis	
DDX17_HUMAN	Q92841	DDX17	Probable ATP-dependent RNA helicase DDX17	13.36439336	11.48528132	17.73009584	14.33146529	12.42483734	16.030780565	12.42483734	16.030780565	0.775061282238941	0.466099	0	1.29022055792965	0.466228	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex	GO:0005524,ATP binding;GO:0008186,ATPase activity, acting on RNA;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0003713,transcription coactivator activity;GO:0016787,hydrolase activity;GO:0003676,nucleic acid binding	GO:0000380,alternative mRNA splicing, via spliceosome;GO:0030521,androgen receptor signaling pathway;GO:0051607,defense response to virus;GO:0001837,epithelial to mesenchymal transition;GO:0031047,gene silencing by RNA;GO:0030520,intracellular estrogen receptor signaling pathway;GO:0010586,miRNA metabolic process;GO:0045445,myoblast differentiation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:2001014,regulation of skeletal muscle cell differentiation;GO:0006357,regulation of transcription by RNA polymerase II;GO:0006396,RNA processing;GO:0006364,rRNA processing	
HTRA1_HUMAN	Q92743	HTRA1	Serine protease HTRA1	0.237110445	0.091986583	0.622633961	0.74669961	0.164548514	0.6846667855	0.164548514	0.6846667855	0.240333717780443	0.030432	-1	4.16088100011648	0.030596	1	GO:0062023,collagen-containing extracellular matrix;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane	GO:0042802,identical protein binding;GO:0005520,insulin-like growth factor binding;GO:0004252,serine-type endopeptidase activity;GO:0008236,serine-type peptidase activity	GO:0060718,chorionic trophoblast cell differentiation;GO:0097187,dentinogenesis;GO:0022617,extracellular matrix disassembly;GO:0030514,negative regulation of BMP signaling pathway;GO:0050687,negative regulation of defense response to virus;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0001890,placenta development;GO:0050679,positive regulation of epithelial cell proliferation;GO:0006508,proteolysis	
PLBL1_HUMAN	Q6P4A8	PLBD1	Phospholipase B-like 1	0.154092586	0.575197019	0.20457052	0.299673109	0.3646448025	0.2521218145	0.3646448025	0.2521218145	1.44630405434433	0.316014	0	0.691417545982984	0.315589	0	GO:0005829,cytosol;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005764,lysosome	GO:0004620,phospholipase activity	GO:0036151,phosphatidylcholine acyl-chain remodeling;GO:0036152,phosphatidylethanolamine acyl-chain remodeling;GO:0036149,phosphatidylinositol acyl-chain remodeling;GO:0009395,phospholipid catabolic process;GO:0006644,phospholipid metabolic process;GO:0016042,lipid catabolic process	
SQSTM_HUMAN	Q13501	SQSTM1	Sequestosome-1	0.244179847	0.166333437	0.470952616	0.445722223	0.205256642	0.4583374195	0.205256642	0.4583374195	0.44782868093972	0.177912	0	2.23299677435043	0.178247	0	GO:0016235,aggresome;GO:0044753,amphisome;GO:0044754,autolysosome;GO:0005776,autophagosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0016234,inclusion body;GO:0043231,intracellular membrane-bounded organelle;GO:0005770,late endosome;GO:0097413,Lewy body;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0000932,P-body;GO:0000407,phagophore assembly site;GO:0016605,PML body;GO:0030017,sarcomere;GO:0097225,sperm midpiece;GO:0005764,lysosome	GO:0019899,enzyme binding;GO:0042802,identical protein binding;GO:0035255,ionotropic glutamate receptor binding;GO:0070530,K63-linked polyubiquitin modification-dependent protein binding;GO:0019901,protein kinase binding;GO:0005080,protein kinase C binding;GO:0004674,protein serine/threonine kinase activity;GO:0044877,protein-containing complex binding;GO:0030971,receptor tyrosine kinase binding;GO:0042169,SH2 domain binding;GO:0043130,ubiquitin binding;GO:0031625,ubiquitin protein ligase binding;GO:0008270,zinc ion binding	GO:0035973,aggrephagy;GO:0006915,apoptotic process;GO:0006914,autophagy;GO:0000422,autophagy of mitochondrion;GO:0030154,cell differentiation;GO:0016197,endosomal transport;GO:0007032,endosome organization;GO:0002376,immune system process;GO:0070498,interleukin-1-mediated signaling pathway;GO:0035556,intracellular signal transduction;GO:0016236,macroautophagy;GO:0000423,mitophagy;GO:0043066,negative regulation of apoptotic process;GO:0031397,negative regulation of protein ubiquitination;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0000425,pexophagy;GO:0043065,positive regulation of apoptotic process;GO:1900273,positive regulation of long-term synaptic potentiation;GO:1903078,positive regulation of protein localization to plasma membrane;GO:0001934,positive regulation of protein phosphorylation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0008104,protein localization;GO:1905719,protein localization to perinuclear region of cytoplasm;GO:0043122,regulation of I-kappaB kinase/NF-kappaB signaling;GO:0010821,regulation of mitochondrion organization;GO:0061635,regulation of protein complex stability;GO:0046578,regulation of Ras protein signal transduction;GO:0002931,response to ischemia;GO:0098780,response to mitochondrial depolarisation;GO:0061912,selective autophagy;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:8878,path:hsa04140,Autophagy - animal;hsa:8878,path:hsa04137,Mitophagy - animal;hsa:8878,path:hsa04217,Necroptosis;hsa:8878,path:hsa04218,Cellular senescence;hsa:8878,path:hsa04380,Osteoclast differentiation;hsa:8878,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:8878,path:hsa05131,Shigellosis
LYSC_HUMAN	P61626	LYZ	Lysozyme C	5.882371517	28.58040819	6.420974555	15.28223773	17.2313898535	10.8516061425	17.2313898535	10.8516061425	1.58791146925373	0.288557	0	0.629758030823953	0.288089	0	GO:0035578,azurophil granule lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen	GO:0042802,identical protein binding;GO:0003796,lysozyme activity	GO:1990000,amyloid fibril formation;GO:0019730,antimicrobial humoral response;GO:0019835,cytolysis;GO:0042742,defense response to bacterium;GO:0050829,defense response to Gram-negative bacterium;GO:0050830,defense response to Gram-positive bacterium;GO:0006954,inflammatory response;GO:0031640,killing of cells of other organism;GO:0043312,neutrophil degranulation;GO:0001895,retina homeostasis;GO:0008152,metabolic process	hsa:4069,path:hsa04970,Salivary secretion
KS6A1_HUMAN	Q15418	RPS6KA1	Ribosomal protein S6 kinase alpha-1	0.160054249	0.20830134	0.424511493	0.414686454	0.1841777945	0.4195989735	0.1841777945	0.4195989735	0.438937666991218	0.170042	0	2.27822781046496	0.170377	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0045202,synapse	GO:0005524,ATP binding;GO:0043027,cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0000287,magnesium ion binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0004712,protein serine/threonine/tyrosine kinase activity;GO:0106311,protein threonine kinase activity;GO:0004711,ribosomal protein S6 kinase activity;GO:0004672,protein kinase activity	GO:0007049,cell cycle;GO:0007268,chemical synaptic transmission;GO:0072574,hepatocyte proliferation;GO:0035556,intracellular signal transduction;GO:0043066,negative regulation of apoptotic process;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0018105,peptidyl-serine phosphorylation;GO:0045597,positive regulation of cell differentiation;GO:0030307,positive regulation of cell growth;GO:2000491,positive regulation of hepatic stellate cell activation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0043620,regulation of DNA-templated transcription in response to stress;GO:0043555,regulation of translation in response to stress;GO:0007165,signal transduction	hsa:6195,path:hsa04010,MAPK signaling pathway;hsa:6195,path:hsa04150,mTOR signaling pathway;hsa:6195,path:hsa04114,Oocyte meiosis;hsa:6195,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:6195,path:hsa04720,Long-term potentiation;hsa:6195,path:hsa04722,Neurotrophin signaling pathway;hsa:6195,path:hsa04714,Thermogenesis;hsa:6195,path:hsa04931,Insulin resistance;hsa:6195,path:hsa05135,Yersinia infection
SC24B_HUMAN	O95487	SEC24B	Protein transport protein Sec24B	0.211179366	0.226488941	0.421062149	0.455683782	0.2188341535	0.4383729655	0.2188341535	0.4383729655	0.499196279703065	0.224403	0	2.00322005723846	0.224732	0	GO:0030127,COPII vesicle coat;GO:0005829,cytosol;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0012507,ER to Golgi transport vesicle membrane	GO:0000149,SNARE binding;GO:0008270,zinc ion binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0035909,aorta morphogenesis;GO:0060088,auditory receptor cell stereocilium organization;GO:0021747,cochlear nucleus development;GO:0048208,COPII vesicle coating;GO:0090110,COPII-coated vesicle cargo loading;GO:0060982,coronary artery morphogenesis;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0060463,lung lobe morphogenesis;GO:0001843,neural tube closure;GO:0003151,outflow tract morphogenesis;GO:0061156,pulmonary artery morphogenesis;GO:1901301,regulation of cargo loading into COPII-coated vesicle;GO:0090178,regulation of establishment of planar polarity involved in neural tube closure	hsa:10427,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:10427,path:hsa05130,Pathogenic Escherichia coli infection
MA2C1_HUMAN	Q9NTJ4	MAN2C1	Alpha-mannosidase 2C1	0.128780786	0.11913828	0.176364384	0.261446007	0.123959533	0.2189051955	0.123959533	0.2189051955	0.566270401745673	0.286125	0	1.76594078891859	0.286423	0	GO:0005829,cytosol;GO:0005654,nucleoplasm	GO:0004559,alpha-mannosidase activity;GO:0030246,carbohydrate binding;GO:0046872,metal ion binding	GO:0006013,mannose metabolic process;GO:0009313,oligosaccharide catabolic process	hsa:4123,path:hsa00511,Other glycan degradation
KHDR1_HUMAN	Q07666	KHDRBS1	KH domain-containing, RNA-binding, signal transduction-associated protein 1	1.381688898	0.849348059	1.314841464	0.652237743	1.1155184785	0.9835396035	1.1155184785	0.9835396035	1.13418765704029	0.392050	0	0.881688311270767	0.391767	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070618,Grb2-Sos complex;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0003677,DNA binding;GO:0042802,identical protein binding;GO:0003729,mRNA binding;GO:0008143,poly(A) binding;GO:0008266,poly(U) RNA binding;GO:0019904,protein domain specific binding;GO:1990782,protein tyrosine kinase binding;GO:0044877,protein-containing complex binding;GO:0003723,RNA binding;GO:0042169,SH2 domain binding;GO:0017124,SH3 domain binding;GO:0035591,signaling adaptor activity	GO:0000082,G1/S transition of mitotic cell cycle;GO:0000086,G2/M transition of mitotic cell cycle;GO:0006397,mRNA processing;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0046833,positive regulation of RNA export from nucleus;GO:0045948,positive regulation of translational initiation;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0048024,regulation of mRNA splicing, via spliceosome;GO:0046831,regulation of RNA export from nucleus;GO:0007283,spermatogenesis;GO:0050852,T cell receptor signaling pathway	
VPS29_HUMAN	Q9UBQ0	VPS29	Vacuolar protein sorting-associated protein 29	1.715990617	17.61381784	0.253438753	0.021443897	9.6649042285	0.137441325	9.6649042285	0.137441325	70.3202201266613	0.000088	1	0.0142206608312487	0.000085	-1	GO:0005829,cytosol;GO:0005769,early endosome;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005770,late endosome;GO:0030904,retromer complex;GO:0030906,retromer, cargo-selective complex	GO:0046872,metal ion binding	GO:0032456,endocytic recycling;GO:0006886,intracellular protein transport;GO:0042147,retrograde transport, endosome to Golgi;GO:0016032,viral process;GO:0016055,Wnt signaling pathway;GO:0015031,protein transport	hsa:51699,path:hsa04144,Endocytosis
XPO7_HUMAN	Q9UIA9	XPO7	Exportin-7	3.780852077	3.299011861	3.10666143	32.06557057	3.539931969	17.586116	3.539931969	17.586116	0.201291289617332	0.015960	-1	4.96792485110044	0.016068	1	GO:0005737,cytoplasm;GO:0005643,nuclear pore;GO:0005634,nucleus	GO:0005049,nuclear export signal receptor activity;GO:0031267,small GTPase binding	GO:0006611,protein export from nucleus;GO:0006886,intracellular protein transport	
HIBCH_HUMAN	Q6NVY1	HIBCH	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	1.242370646	1.313197374	1.431156759	1.086921256	1.27778401	1.2590390075	1.27778401	1.2590390075	1.0148883413368	0.428457	0	0.985330069594469	0.428249	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0003860,3-hydroxyisobutyryl-CoA hydrolase activity	GO:0009083,branched-chain amino acid catabolic process;GO:0006574,valine catabolic process	hsa:26275,path:hsa00640,Propanoate metabolism;hsa:26275,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:26275,path:hsa00410,beta-Alanine metabolism
SEC63_HUMAN	Q9UGP8	SEC63	Translocation protein SEC63 homolog	0.494817403	0.430734863	0.656798414	0.570237952	0.462776133	0.613518183	0.462776133	0.613518183	0.754298969163559	0.449638	0	1.32573427895427	0.449786	0	GO:0005783,endoplasmic reticulum;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0031207,Sec62/Sec63 complex	GO:0008320,protein transmembrane transporter activity;GO:0003723,RNA binding;GO:0038023,signaling receptor activity	GO:0001889,liver development;GO:0010259,multicellular organism aging;GO:0006807,nitrogen compound metabolic process;GO:0006620,posttranslational protein targeting to endoplasmic reticulum membrane;GO:0031204,posttranslational protein targeting to membrane, translocation;GO:0006612,protein targeting to membrane;GO:0006614,SRP-dependent cotranslational protein targeting to membrane	hsa:11231,path:hsa03060,Protein export;hsa:11231,path:hsa04141,Protein processing in endoplasmic reticulum
WWP1_HUMAN	Q9H0M0	WWP1	NEDD4-like E3 ubiquitin-protein ligase WWP1	2.55E-05	2.55E-05	0.069705236	2.55E-05	2.55e-005	0.034865368	2.55e-005	0.034865368	0.000731384794217574	0.000000	-1	1367.26933333333	0.000000	1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0000151,ubiquitin ligase complex	GO:0061630,ubiquitin protein ligase activity;GO:0004842,ubiquitin-protein transferase activity	GO:0007417,central nervous system development;GO:0034220,ion transmembrane transport;GO:0045892,negative regulation of transcription, DNA-templated;GO:0045732,positive regulation of protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209,protein polyubiquitination;GO:0016567,protein ubiquitination;GO:0007165,signal transduction;GO:0046718,viral entry into host cell	hsa:11059,path:hsa04120,Ubiquitin mediated proteolysis;hsa:11059,path:hsa04144,Endocytosis
ALDH2_HUMAN	P05091	ALDH2	Aldehyde dehydrogenase, mitochondrial	2.905217152	20.81172267	9.413116527	11.4762409	11.858469911	10.4446787135	11.858469911	10.4446787135	1.13535995086882	0.391716	0	0.880777941158449	0.391432	0	GO:0070062,extracellular exosome;GO:0005759,mitochondrial matrix	GO:0004029,aldehyde dehydrogenase (NAD+) activity;GO:0004030,aldehyde dehydrogenase [NAD(P)+] activity;GO:0009055,electron transfer activity;GO:0043878,glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity;GO:0051287,NAD binding;GO:0016620,oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	GO:0006066,alcohol metabolic process;GO:0005975,carbohydrate metabolic process;GO:0006068,ethanol catabolic process;GO:0006069,ethanol oxidation	hsa:217,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:217,path:hsa00053,Ascorbate and aldarate metabolism;hsa:217,path:hsa00620,Pyruvate metabolism;hsa:217,path:hsa00071,Fatty acid degradation;hsa:217,path:hsa00561,Glycerolipid metabolism;hsa:217,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:217,path:hsa00310,Lysine degradation;hsa:217,path:hsa00330,Arginine and proline metabolism;hsa:217,path:hsa00340,Histidine metabolism;hsa:217,path:hsa00380,Tryptophan metabolism;hsa:217,path:hsa00410,beta-Alanine metabolism
CHID1_HUMAN	Q9BWS9	CHID1	Chitinase domain-containing protein 1	0.972643525	0.890346689	1.370660707	1.067238782	0.931495107	1.2189497445	0.931495107	1.2189497445	0.764178434101144	0.457518	0	1.30859489796547	0.457656	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005770,late endosome;GO:0043202,lysosomal lumen;GO:0005764,lysosome;GO:0016020,membrane;GO:0005634,nucleus;GO:0005802,trans-Golgi network	GO:0008061,chitin binding;GO:0070492,oligosaccharide binding	GO:0005975,carbohydrate metabolic process;GO:0045087,innate immune response;GO:1900016,negative regulation of cytokine production involved in inflammatory response;GO:0002576,platelet degranulation	
ERF1_HUMAN	P62495	ETF1	Eukaryotic peptide chain release factor subunit 1	2.368428033	2.071263658	2.455820337	0.991666852	2.2198458455	1.7237435945	2.2198458455	1.7237435945	1.28780513098522	0.351586	0	0.776514999000637	0.351224	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0018444,translation release factor complex	GO:0043022,ribosome binding;GO:0003723,RNA binding;GO:1990825,sequence-specific mRNA binding;GO:0003747,translation release factor activity;GO:0016149,translation release factor activity, codon specific;GO:0008079,translation termination factor activity	GO:0002184,cytoplasmic translational termination;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006479,protein methylation;GO:0006449,regulation of translational termination;GO:0006415,translational termination	hsa:2107,path:hsa03015,mRNA surveillance pathway
CP4F2_HUMAN	P78329	CYP4F2	Cytochrome P450 4F2	2.55E-05	2.55E-05	2.55E-05	2.55E-05	2.55e-005	2.55e-005	2.55e-005	2.55e-005	1	0.433351	0	1	0.433154	0	GO:0016324,apical plasma membrane;GO:0005737,cytoplasm;GO:0005789,endoplasmic reticulum membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016021,integral component of membrane	GO:0018685,alkane 1-monooxygenase activity;GO:0052871,alpha-tocopherol omega-hydroxylase activity;GO:0008392,arachidonic acid epoxygenase activity;GO:0008391,arachidonic acid monooxygenase activity;GO:0052869,arachidonic acid omega-hydroxylase activity;GO:0070330,aromatase activity;GO:0102207,docosanoate omega-hydroxylase activity;GO:0020037,heme binding;GO:0005506,iron ion binding;GO:0050051,leukotriene-B4 20-monooxygenase activity;GO:0016709,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0052872,tocotrienol omega-hydroxylase activity;GO:0016705,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0004497,monooxygenase activity	GO:0019369,arachidonic acid metabolic process;GO:0007596,blood coagulation;GO:0017144,drug metabolic process;GO:0019373,epoxygenase P450 pathway;GO:0006690,icosanoid metabolic process;GO:0036101,leukotriene B4 catabolic process;GO:0006691,leukotriene metabolic process;GO:0001676,long-chain fatty acid metabolic process;GO:0042361,menaquinone catabolic process;GO:0032304,negative regulation of icosanoid secretion;GO:0097267,omega-hydroxylase P450 pathway;GO:0042376,phylloquinone catabolic process;GO:0032305,positive regulation of icosanoid secretion;GO:0003095,pressure natriuresis;GO:0008217,regulation of blood pressure;GO:0003091,renal water homeostasis;GO:0055078,sodium ion homeostasis;GO:0000038,very long-chain fatty acid metabolic process;GO:0042360,vitamin E metabolic process;GO:0042377,vitamin K catabolic process	hsa:8529,path:hsa00590,Arachidonic acid metabolism
COR1B_HUMAN	Q9BR76	CORO1B	Coronin-1B	4.421880519	2.769035881	4.206616503	4.489829419	3.5954582	4.348222961	3.5954582	4.348222961	0.826879907550352	0.496959	0	1.20936546029099	0.496902	0	GO:0005884,actin filament;GO:0031252,cell leading edge;GO:0071944,cell periphery;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0001725,stress fiber;GO:0005856,cytoskeleton	GO:0051015,actin filament binding;GO:0071933,Arp2/3 complex binding;GO:0045296,cadherin binding;GO:0042802,identical protein binding	GO:0030036,actin cytoskeleton organization;GO:0090135,actin filament branching;GO:0051017,actin filament bundle assembly;GO:0007015,actin filament organization;GO:0016477,cell migration;GO:0036120,cellular response to platelet-derived growth factor stimulus;GO:0035767,endothelial cell chemotaxis;GO:0034316,negative regulation of Arp2/3 complex-mediated actin nucleation;GO:0071672,negative regulation of smooth muscle cell chemotaxis;GO:2000394,positive regulation of lamellipodium morphogenesis;GO:1902463,protein localization to cell leading edge;GO:0034315,regulation of Arp2/3 complex-mediated actin nucleation;GO:0031529,ruffle organization;GO:0042060,wound healing	
GMDS_HUMAN	O60547	GMDS	GDP-mannose 4,6 dehydratase	0.532371662	0.301653184	0.648322254	1.316225406	0.417012423	0.98227383	0.417012423	0.98227383	0.424537853156487	0.157454	0	2.35550256017193	0.157787	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0008446,GDP-mannose 4,6-dehydratase activity;GO:0042802,identical protein binding;GO:0070401,NADP+ binding	GO:0042351,'de novo' GDP-L-fucose biosynthetic process;GO:0019673,GDP-mannose metabolic process;GO:0007219,Notch signaling pathway	hsa:2762,path:hsa00051,Fructose and mannose metabolism;hsa:2762,path:hsa00520,Amino sugar and nucleotide sugar metabolism
SYCC_HUMAN	P49589	CARS1	Cysteine--tRNA ligase, cytoplasmic	0.670257855	0.461575147	0.978485007	1.17863099	0.565916501	1.0785579985	0.565916501	1.0785579985	0.524697329014338	0.247851	0	1.90586066423958	0.248171	0	GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0005524,ATP binding;GO:0004817,cysteine-tRNA ligase activity;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0042803,protein homodimerization activity;GO:0000049,tRNA binding;GO:0016874,ligase activity	GO:0006423,cysteinyl-tRNA aminoacylation;GO:0006418,tRNA aminoacylation for protein translation	hsa:833,path:hsa00970,Aminoacyl-tRNA biosynthesis
MOGS_HUMAN	Q13724	MOGS	Mannosyl-oligosaccharide glucosidase	2.137093949	2.34708692	6.309578453	11.56680007	2.2420904345	8.9381892615	2.2420904345	8.9381892615	0.25084392027337	0.035220	-1	3.98654270316856	0.035399	1	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0015926,glucosidase activity;GO:0004573,mannosyl-oligosaccharide glucosidase activity	GO:0009311,oligosaccharide metabolic process;GO:0006457,protein folding;GO:0006487,protein N-linked glycosylation;GO:0019082,viral protein processing	hsa:7841,path:hsa00510,N-Glycan biosynthesis;hsa:7841,path:hsa04141,Protein processing in endoplasmic reticulum
STING_HUMAN	Q86WV6	STING1	Stimulator of interferon genes protein	0.252992288	0.983323031	0.389444586	0.857300615	0.6181576595	0.6233726005	0.6181576595	0.6233726005	0.991634311492329	0.436138	0	1.00843626366163	0.435947	0	GO:0005776,autophagosome;GO:0000421,autophagosome membrane;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0005768,endosome;GO:0005794,Golgi apparatus;GO:0030176,integral component of endoplasmic reticulum membrane;GO:1990701,integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane;GO:0005741,mitochondrial outer membrane;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm;GO:0005777,peroxisome;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0016021,integral component of membrane	GO:0035438,cyclic-di-GMP binding;GO:0061507,cyclic-GMP-AMP binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:0019901,protein kinase binding;GO:0008134,transcription factor binding;GO:0031625,ubiquitin protein ligase binding;GO:0000166,nucleotide binding	GO:0002218,activation of innate immune response;GO:0000045,autophagosome assembly;GO:0071360,cellular response to exogenous dsRNA;GO:0035458,cellular response to interferon-beta;GO:0071407,cellular response to organic cyclic compound;GO:0051607,defense response to virus;GO:0045087,innate immune response;GO:0043312,neutrophil degranulation;GO:0002230,positive regulation of defense response to virus by host;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0032728,positive regulation of interferon-beta production;GO:0016239,positive regulation of macroautophagy;GO:0032092,positive regulation of protein binding;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0032481,positive regulation of type I interferon production;GO:0051259,protein complex oligomerization;GO:0050727,regulation of inflammatory response;GO:0032479,regulation of type I interferon production;GO:0061709,reticulophagy;GO:0016032,viral process	hsa:340061,path:hsa04621,NOD-like receptor signaling pathway;hsa:340061,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:340061,path:hsa04623,Cytosolic DNA-sensing pathway;hsa:340061,path:hsa05131,Shigellosis;hsa:340061,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:340061,path:hsa05168,Herpes simplex virus 1 infection;hsa:340061,path:hsa05163,Human cytomegalovirus infection
WDR37_HUMAN	Q9Y2I8	WDR37	WD repeat-containing protein 37	0.229600248	0.0906962	0.248958197	0.49865797	0.160148224	0.3738080835	0.160148224	0.3738080835	0.428423651250442	0.160830	0	2.3341381762685	0.161164	0	GO:0005737,cytoplasm;GO:0005634,nucleus;GO:0030687,preribosome, large subunit precursor			
PEPL1_HUMAN	Q8NDH3	NPEPL1	Probable aminopeptidase NPEPL1	0.404773465	0.206634197	0.366077311	0.176619582	0.305703831	0.2713484465	0.305703831	0.2713484465	1.12660984406999	0.394223	0	0.88761873088859	0.393944	0	GO:0005737,cytoplasm;GO:0005634,nucleus	GO:0030145,manganese ion binding;GO:0070006,metalloaminopeptidase activity		
TMX2_HUMAN	Q9Y320	TMX2	Thioredoxin-related transmembrane protein 2	0.200086675	0.093646942	0.21159975	0.14694004	0.1468668085	0.179269895	0.1468668085	0.179269895	0.81924970447492	0.499863	0	1.22062906405432	0.499953	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0043227,membrane-bounded organelle;GO:0044233,mitochondria-associated endoplasmic reticulum membrane;GO:0031966,mitochondrial membrane;GO:0005739,mitochondrion	GO:0015036,disulfide oxidoreductase activity;GO:0042802,identical protein binding	GO:0007420,brain development	
TOM70_HUMAN	O94826	TOMM70	Mitochondrial import receptor subunit TOM70	1.013571534	0.897940792	1.134097813	1.221669328	0.955756163	1.1778835705	0.955756163	1.1778835705	0.811418196956675	0.494007	0	1.23241012310375	0.494104	0	GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005742,mitochondrial outer membrane translocase complex;GO:0005739,mitochondrion	GO:0030943,mitochondrion targeting sequence binding;GO:0008320,protein transmembrane transporter activity	GO:0002218,activation of innate immune response;GO:0098586,cellular response to virus;GO:0016236,macroautophagy;GO:0002230,positive regulation of defense response to virus by host;GO:0032728,positive regulation of interferon-beta production;GO:0030150,protein import into mitochondrial matrix;GO:0045039,protein insertion into mitochondrial inner membrane;GO:0006626,protein targeting to mitochondrion;GO:0042981,regulation of apoptotic process	
RL7A_HUMAN	P62424	RPL7A	60S ribosomal protein L7a	3.793897446	2.321495506	0.934461063	0.604726131	3.057696476	0.769593597	3.057696476	0.769593597	3.97313138768227	0.091656	0	0.251690644588361	0.091148	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005634,nucleus;GO:0042788,polysomal ribosome;GO:0045202,synapse	GO:0045296,cadherin binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000470,maturation of LSU-rRNA;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription;GO:0042254,ribosome biogenesis	hsa:6130,path:hsa03010,Ribosome
PRP31_HUMAN	Q8WWY3	PRPF31	U4/U6 small nuclear ribonucleoprotein Prp31	0.41201919	0.146623035	0.682529007	0.212015816	0.2793211125	0.4472724115	0.2793211125	0.4472724115	0.624498863149756	0.339011	0	1.60128393982392	0.339269	0	GO:0015030,Cajal body;GO:0071339,MLL1 complex;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0071011,precatalytic spliceosome;GO:0097526,spliceosomal tri-snRNP complex;GO:0071005,U2-type precatalytic spliceosome;GO:0005684,U2-type spliceosomal complex;GO:0005687,U4 snRNP;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005690,U4atac snRNP;GO:0005681,spliceosomal complex	GO:0042802,identical protein binding;GO:0043021,ribonucleoprotein complex binding;GO:0003723,RNA binding;GO:0070990,snRNP binding;GO:0030621,U4 snRNA binding;GO:0030622,U4atac snRNA binding	GO:0000398,mRNA splicing, via spliceosome;GO:0071166,ribonucleoprotein complex localization;GO:0000244,spliceosomal tri-snRNP complex assembly	hsa:26121,path:hsa03040,Spliceosome
RBM10_HUMAN	P98175	RBM10	RNA-binding protein 10	0.23583408	0.335081094	0.201517914	0.130399158	0.285457587	0.165958536	0.285457587	0.165958536	1.72005365846322	0.265992	0	0.58137721173969	0.265493	0	GO:0016607,nuclear speck;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0035198,miRNA binding;GO:0003723,RNA binding	GO:0070935,3'-UTR-mediated mRNA stabilization;GO:0000398,mRNA splicing, via spliceosome;GO:0008285,negative regulation of cell population proliferation;GO:0048025,negative regulation of mRNA splicing, via spliceosome;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0034393,positive regulation of smooth muscle cell apoptotic process;GO:0000381,regulation of alternative mRNA splicing, via spliceosome	
FNBP1_HUMAN	Q96RU3	FNBP1	Formin-binding protein 1	0.290890424	0.257149911	0.518286438	0.340886913	0.2740201675	0.4295866755	0.2740201675	0.4295866755	0.63786933610328	0.350938	0	1.56771919169052	0.351186	0	GO:0005938,cell cortex;GO:0005905,clathrin-coated pit;GO:0031410,cytoplasmic vesicle;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0005764,lysosome;GO:0005886,plasma membrane;GO:0005737,cytoplasm	GO:0042802,identical protein binding;GO:0008289,lipid binding	GO:0006897,endocytosis;GO:0061024,membrane organization;GO:0007165,signal transduction	hsa:23048,path:hsa05131,Shigellosis
SC11C_HUMAN	Q9BY50	SEC11C	Signal peptidase complex catalytic subunit SEC11C	0.975609641	1.227261118	0.035860139	2.55E-05	1.1014353795	0.0179428195	1.1014353795	0.0179428195	61.3858585324341	0.000137	1	0.0162903969074838	0.000133	-1	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0005787,signal peptidase complex	GO:0008233,peptidase activity;GO:0004252,serine-type endopeptidase activity	GO:0006465,signal peptide processing	hsa:90701,path:hsa03060,Protein export
ERH_HUMAN	P84090	ERH	Enhancer of rudimentary homolog	0.164597783	0.131992255	0.149290833	0.1414518	0.148295019	0.1453713165	0.148295019	0.1453713165	1.02011196273372	0.426759	0	0.98028455358976	0.426548	0	GO:0034709,methylosome;GO:0030496,midbody;GO:0005634,nucleus	GO:0008327,methyl-CpG binding;GO:0003723,RNA binding	GO:0007049,cell cycle;GO:0006139,nucleobase-containing compound metabolic process;GO:0006213,pyrimidine nucleoside metabolic process	
OFUT1_HUMAN	Q9H488	POFUT1	GDP-fucose protein O-fucosyltransferase 1	0.147810171	0.156673162	0.423774382	0.50133717	0.1522416665	0.462555776	0.1522416665	0.462555776	0.329131478621942	0.081663	0	3.03829947894061	0.081939	0	GO:0005783,endoplasmic reticulum;GO:0016020,membrane	GO:0008417,fucosyltransferase activity;GO:0046922,peptide-O-fucosyltransferase activity	GO:0001525,angiogenesis;GO:0006004,fucose metabolic process;GO:0007507,heart development;GO:0007399,nervous system development;GO:0007219,Notch signaling pathway;GO:0016266,O-glycan processing;GO:0036066,protein O-linked fucosylation;GO:0006493,protein O-linked glycosylation;GO:0008593,regulation of Notch signaling pathway;GO:0006355,regulation of transcription, DNA-templated;GO:0001756,somitogenesis	hsa:23509,path:hsa00514,Other types of O-glycan biosynthesis
ITSN2_HUMAN	Q9NZM3	ITSN2	Intersectin-2	0.0418969	0.030272419	0.126963924	2.55E-05	0.0360846595	0.063494712	0.0360846595	0.063494712	0.568309680654981	0.287996	0	1.75960402231314	0.288293	0	GO:0005813,centrosome;GO:0005905,clathrin-coated pit;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0098793,presynapse	GO:0005509,calcium ion binding;GO:0005085,guanyl-nucleotide exchange factor activity;GO:0060090,molecular adaptor activity	GO:0030154,cell differentiation;GO:0150007,clathrin-dependent synaptic vesicle endocytosis;GO:0006897,endocytosis;GO:0016197,endosomal transport;GO:1903861,positive regulation of dendrite extension;GO:0016032,viral process	
HYEP_HUMAN	P07099	EPHX1	Epoxide hydrolase 1	10.93581382	25.36108386	33.91542454	42.84208173	18.14844884	38.378753135	18.14844884	38.378753135	0.472877500114752	0.200404	0	2.11471258361274	0.200738	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane	GO:0033961,cis-stilbene-oxide hydrolase activity;GO:0004301,epoxide hydrolase activity;GO:0016787,hydrolase activity	GO:0019369,arachidonic acid metabolic process;GO:0019439,aromatic compound catabolic process;GO:0097176,epoxide metabolic process;GO:0009636,response to toxic substance;GO:0006805,xenobiotic metabolic process	hsa:2052,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:2052,path:hsa04976,Bile secretion;hsa:2052,path:hsa05204,Chemical carcinogenesis
PGP_HUMAN	A6NDG6	PGP	Glycerol-3-phosphate phosphatase	0.17139941	0.152840242	0.127432016	0.188101563	0.162119826	0.1577667895	0.162119826	0.1577667895	1.0275915895468	0.424345	0	0.973149264914706	0.424129	0	GO:0005737,cytoplasm	GO:0000121,glycerol-1-phosphatase activity;GO:0043136,glycerol-3-phosphatase activity;GO:0000287,magnesium ion binding;GO:0098519,nucleotide phosphatase activity, acting on free nucleotides;GO:0016791,phosphatase activity;GO:0008967,phosphoglycolate phosphatase activity;GO:0004725,protein tyrosine phosphatase activity	GO:0016311,dephosphorylation;GO:0006114,glycerol biosynthetic process;GO:0006650,glycerophospholipid metabolic process;GO:0045721,negative regulation of gluconeogenesis;GO:0035335,peptidyl-tyrosine dephosphorylation	hsa:283871,path:hsa00630,Glyoxylate and dicarboxylate metabolism
CBX5_HUMAN	P45973	CBX5	Chromobox protein homolog 5	0.433060862	0.611969153	0.047070279	0.070001759	0.5225150075	0.058536019	0.5225150075	0.058536019	8.92638441128017	0.022063	1	0.112027440666381	0.021821	-1	GO:0010369,chromocenter;GO:0000781,chromosome, telomeric region;GO:0000792,heterochromatin;GO:0000118,histone deacetylase complex;GO:0035097,histone methyltransferase complex;GO:0000776,kinetochore;GO:0005635,nuclear envelope;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005721,pericentric heterochromatin;GO:0032991,protein-containing complex;GO:1990904,ribonucleoprotein complex;GO:0090734,site of DNA damage;GO:0017053,transcription repressor complex	GO:0003682,chromatin binding;GO:0042826,histone deacetylase binding;GO:0042802,identical protein binding;GO:0035064,methylated histone binding;GO:0044877,protein-containing complex binding;GO:0030674,protein-macromolecule adaptor activity;GO:0070491,repressing transcription factor binding;GO:0043021,ribonucleoprotein complex binding	GO:0007596,blood coagulation;GO:0006974,cellular response to DNA damage stimulus;GO:0070317,negative regulation of G0 to G1 transition;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0016032,viral process	
NLRX1_HUMAN	Q86UT6	NLRX1	NLR family member X1	0.071574198	0.109699607	0.106336616	0.027466506	0.0906369025	0.066901561	0.0906369025	0.066901561	1.35478008502672	0.335865	0	0.738127177283006	0.335474	0	GO:0030054,cell junction;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0005886,plasma membrane	GO:0005524,ATP binding	GO:0045087,innate immune response;GO:0035556,intracellular signal transduction;GO:0043124,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0050728,negative regulation of inflammatory response;GO:0045824,negative regulation of innate immune response;GO:0032688,negative regulation of interferon-beta production;GO:0032715,negative regulation of interleukin-6 production;GO:0039536,negative regulation of RIG-I signaling pathway;GO:0032480,negative regulation of type I interferon production;GO:0016032,viral process	hsa:79671,path:hsa04621,NOD-like receptor signaling pathway;hsa:79671,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:79671,path:hsa05164,Influenza A
GIMA4_HUMAN	Q9NUV9	GIMAP4	GTPase IMAP family member 4	0.61137706	0.50997304	1.408773471	1.851533766	0.56067505	1.6301536185	0.56067505	1.6301536185	0.343940008866103	0.092301	0	2.90748378851529	0.092591	0	GO:0005829,cytosol	GO:0005525,GTP binding		
ISLR_HUMAN	O14498	ISLR	Immunoglobulin superfamily containing leucine-rich repeat protein	0.639428414	0.761727384	0.182481894	0.511283909	0.700577899	0.3468829015	0.700577899	0.3468829015	2.01963802761838	0.223534	0	0.495138230873595	0.222989	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0031093,platelet alpha granule lumen		GO:0007155,cell adhesion;GO:0002576,platelet degranulation	
CBG_HUMAN	P08185	SERPINA6	Corticosteroid-binding globulin	1.054235465	0.551963471	1.20009797	2.381539526	0.803099468	1.790818748	0.803099468	1.790818748	0.448453797402393	0.178467	0	2.22988411691987	0.178803	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0004867,serine-type endopeptidase inhibitor activity;GO:0005496,steroid binding	GO:0006704,glucocorticoid biosynthetic process;GO:0010951,negative regulation of endopeptidase activity	
MARE1_HUMAN	Q15691	MAPRE1	Microtubule-associated protein RP/EB family member 1	2.087950577	5.616206358	1.411243963	1.223770332	3.8520784675	1.3175071475	3.8520784675	1.3175071475	2.92376286140793	0.141830	0	0.342025002506001	0.141265	0	GO:0031253,cell projection membrane;GO:0005813,centrosome;GO:0036064,ciliary basal body;GO:0030981,cortical microtubule cytoskeleton;GO:0005881,cytoplasmic microtubule;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0005874,microtubule;GO:0005815,microtubule organizing center;GO:0035371,microtubule plus-end;GO:1905721,mitotic spindle astral microtubule end;GO:0051233,spindle midzone	GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0051010,microtubule plus-end binding;GO:0008022,protein C-terminus binding;GO:0019901,protein kinase binding;GO:0003723,RNA binding	GO:0051301,cell division;GO:0016477,cell migration;GO:0097711,ciliary basal body-plasma membrane docking;GO:0000086,G2/M transition of mitotic cell cycle;GO:0001578,microtubule bundle formation;GO:0046785,microtubule polymerization;GO:0007052,mitotic spindle organization;GO:0031115,negative regulation of microtubule polymerization;GO:1905515,non-motile cilium assembly;GO:0030335,positive regulation of cell migration;GO:1903033,positive regulation of microtubule plus-end binding;GO:0031116,positive regulation of microtubule polymerization;GO:0008104,protein localization;GO:0071539,protein localization to centrosome;GO:0035372,protein localization to microtubule;GO:1904825,protein localization to microtubule plus-end;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0031110,regulation of microtubule polymerization or depolymerization;GO:0051225,spindle assembly	
CYB5B_HUMAN	O43169	CYB5B	Cytochrome b5 type B	0.553147112	0.141829415	0.063145266	0.030490154	0.3474882635	0.04681771	0.3474882635	0.04681771	7.42215421258323	0.031631	1	0.13473177346607	0.031329	-1	GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:1903958,nitric-oxide synthase complex	GO:0009055,electron transfer activity;GO:0008047,enzyme activator activity;GO:0020037,heme binding;GO:0046872,metal ion binding	GO:0006809,nitric oxide biosynthetic process;GO:0006979,response to oxidative stress;GO:0006805,xenobiotic metabolic process	
HRG_HUMAN	P04196	HRG	Histidine-rich glycoprotein	1.214454918	0.952349188	2.796370216	6.656627251	1.083402053	4.7264987335	1.083402053	4.7264987335	0.229218733376817	0.025776	-1	4.36264516982598	0.025924	1	GO:0072562,blood microparticle;GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0036019,endolysosome;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005886,plasma membrane;GO:0031093,platelet alpha granule lumen	GO:0004869,cysteine-type endopeptidase inhibitor activity;GO:0004866,endopeptidase inhibitor activity;GO:0020037,heme binding;GO:0043395,heparan sulfate proteoglycan binding;GO:0008201,heparin binding;GO:0019865,immunoglobulin binding;GO:0046872,metal ion binding;GO:0004867,serine-type endopeptidase inhibitor activity;GO:0005102,signaling receptor binding;GO:0008270,zinc ion binding	GO:0001525,angiogenesis;GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006935,chemotaxis;GO:0051838,cytolysis by host of symbiont cells;GO:0050832,defense response to fungus;GO:0042730,fibrinolysis;GO:0015886,heme transport;GO:0016525,negative regulation of angiogenesis;GO:0043537,negative regulation of blood vessel endothelial cell migration;GO:0007162,negative regulation of cell adhesion;GO:0033629,negative regulation of cell adhesion mediated by integrin;GO:0030308,negative regulation of cell growth;GO:0008285,negative regulation of cell population proliferation;GO:0010951,negative regulation of endopeptidase activity;GO:2001027,negative regulation of endothelial cell chemotaxis;GO:0051918,negative regulation of fibrinolysis;GO:0010593,negative regulation of lamellipodium assembly;GO:1900747,negative regulation of vascular endothelial growth factor signaling pathway;GO:0030168,platelet activation;GO:0002576,platelet degranulation;GO:0043065,positive regulation of apoptotic process;GO:2000504,positive regulation of blood vessel remodeling;GO:0051894,positive regulation of focal adhesion assembly;GO:0002839,positive regulation of immune response to tumor cell;GO:0032956,regulation of actin cytoskeleton organization;GO:0030193,regulation of blood coagulation;GO:0010468,regulation of gene expression;GO:0050730,regulation of peptidyl-tyrosine phosphorylation;GO:0010543,regulation of platelet activation;GO:0043254,regulation of protein-containing complex assembly	
BCS1_HUMAN	Q9Y276	BCS1L	Mitochondrial chaperone BCS1	0.022426445	0.035211311	0.088899147	0.086621615	0.028818878	0.087760381	0.028818878	0.087760381	0.328381413932102	0.081138	0	3.04523933929697	0.081413	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005750,mitochondrial respiratory chain complex III;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0016887,ATPase activity	GO:0033617,mitochondrial cytochrome c oxidase assembly;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0034551,mitochondrial respiratory chain complex III assembly;GO:0007005,mitochondrion organization;GO:0032979,protein insertion into mitochondrial inner membrane from matrix	
THRB_HUMAN	P00734	F2	Prothrombin	0.891784585	1.915652429	1.683100778	18.9579575	1.403718507	10.320529139	1.403718507	10.320529139	0.136012261396126	0.003030	-1	7.35227831472909	0.003062	1	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005796,Golgi lumen;GO:0005886,plasma membrane	GO:0005509,calcium ion binding;GO:0008047,enzyme activator activity;GO:0008083,growth factor activity;GO:0008201,heparin binding;GO:0001530,lipopolysaccharide binding;GO:0004252,serine-type endopeptidase activity;GO:0005102,signaling receptor binding;GO:0070053,thrombospondin receptor activity	GO:0006953,acute-phase response;GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0007596,blood coagulation;GO:0007597,blood coagulation, intrinsic pathway;GO:0007166,cell surface receptor signaling pathway;GO:0044267,cellular protein metabolic process;GO:0051838,cytolysis by host of symbiont cells;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0042730,fibrinolysis;GO:0007186,G protein-coupled receptor signaling pathway;GO:0050900,leukocyte migration;GO:0007275,multicellular organism development;GO:0048712,negative regulation of astrocyte differentiation;GO:1900016,negative regulation of cytokine production involved in inflammatory response;GO:0051918,negative regulation of fibrinolysis;GO:0010544,negative regulation of platelet activation;GO:0045861,negative regulation of proteolysis;GO:0070945,neutrophil-mediated killing of gram-negative bacterium;GO:0030168,platelet activation;GO:0030194,positive regulation of blood coagulation;GO:0030307,positive regulation of cell growth;GO:0008284,positive regulation of cell population proliferation;GO:0032967,positive regulation of collagen biosynthetic process;GO:0090218,positive regulation of lipid kinase activity;GO:0014068,positive regulation of phosphatidylinositol 3-kinase signaling;GO:1900738,positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway;GO:1900182,positive regulation of protein localization to nucleus;GO:0001934,positive regulation of protein phosphorylation;GO:2000379,positive regulation of reactive oxygen species metabolic process;GO:0046427,positive regulation of receptor signaling pathway via JAK-STAT;GO:0051281,positive regulation of release of sequestered calcium ion into cytosol;GO:0006508,proteolysis;GO:0030193,regulation of blood coagulation;GO:0008360,regulation of cell shape;GO:0030449,regulation of complement activation;GO:0051480,regulation of cytosolic calcium ion concentration;GO:0009611,response to wounding	hsa:2147,path:hsa04072,Phospholipase D signaling pathway;hsa:2147,path:hsa04080,Neuroactive ligand-receptor interaction;hsa:2147,path:hsa04810,Regulation of actin cytoskeleton;hsa:2147,path:hsa04610,Complement and coagulation cascades;hsa:2147,path:hsa04611,Platelet activation;hsa:2147,path:hsa05200,Pathways in cancer;hsa:2147,path:hsa05130,Pathogenic Escherichia coli infection
UBP15_HUMAN	Q9Y4E8	USP15	Ubiquitin carboxyl-terminal hydrolase 15	0.337613849	0.358582037	0.400619852	0.217817357	0.348097943	0.3092186045	0.348097943	0.3092186045	1.12573415032018	0.394475	0	0.888309197793794	0.394197	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0004197,cysteine-type endopeptidase activity;GO:0042802,identical protein binding;GO:1990380,Lys48-specific deubiquitinase activity;GO:0046332,SMAD binding;GO:0004843,thiol-dependent deubiquitinase;GO:0005160,transforming growth factor beta receptor binding;GO:0061649,ubiquitin modification-dependent histone binding	GO:0030509,BMP signaling pathway;GO:0035616,histone H2B conserved C-terminal lysine deubiquitination;GO:0035520,monoubiquitinated protein deubiquitination;GO:0060389,pathway-restricted SMAD protein phosphorylation;GO:1900246,positive regulation of RIG-I signaling pathway;GO:0016579,protein deubiquitination;GO:0007179,transforming growth factor beta receptor signaling pathway;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0016032,viral process	hsa:9958,path:hsa04137,Mitophagy - animal
DHX30_HUMAN	Q7L2E3	DHX30	ATP-dependent RNA helicase DHX30	0.174849411	0.137435588	0.173603924	0.069785177	0.1561424995	0.1216945505	0.1561424995	0.1216945505	1.28306895303418	0.352739	0	0.779381340055979	0.352379	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0042645,mitochondrial nucleoid;GO:0005739,mitochondrion;GO:0035770,ribonucleoprotein granule	GO:0005524,ATP binding;GO:0003682,chromatin binding;GO:0003725,double-stranded RNA binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0016787,hydrolase activity;GO:0003676,nucleic acid binding	GO:0007417,central nervous system development;GO:1902775,mitochondrial large ribosomal subunit assembly	
AP3B1_HUMAN	O00203	AP3B1	AP-3 complex subunit beta-1	2.310110073	1.990874882	2.75478537	1.869055919	2.1504924775	2.3119206445	2.1504924775	2.3119206445	0.930175731859987	0.457458	0	1.07506567388121	0.457313	0	GO:0030123,AP-3 adaptor complex;GO:1904115,axon cytoplasm;GO:0030131,clathrin adaptor complex;GO:0030665,clathrin-coated vesicle membrane;GO:0005794,Golgi apparatus;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0045202,synapse	GO:0030742,GTP-dependent protein binding;GO:0019903,protein phosphatase binding	GO:0008089,anterograde axonal transport;GO:0048490,anterograde synaptic vesicle transport;GO:0048007,antigen processing and presentation, exogenous lipid antigen via MHC class Ib;GO:0007596,blood coagulation;GO:0000902,cell morphogenesis;GO:0006464,cellular protein modification process;GO:0006882,cellular zinc ion homeostasis;GO:0090152,establishment of protein localization to mitochondrial membrane involved in mitochondrial fission;GO:0030851,granulocyte differentiation;GO:0002244,hematopoietic progenitor cell differentiation;GO:0048872,homeostasis of number of cells;GO:0006954,inflammatory response;GO:0006886,intracellular protein transport;GO:0060425,lung morphogenesis;GO:0007040,lysosome organization;GO:0032438,melanosome organization;GO:0042789,mRNA transcription by RNA polymerase II;GO:0060155,platelet dense granule organization;GO:0051138,positive regulation of NK T cell differentiation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0034394,protein localization to cell surface;GO:0006622,protein targeting to lysosome;GO:0050790,regulation of catalytic activity;GO:0003016,respiratory system process;GO:0007338,single fertilization;GO:0098773,skin epidermis development;GO:0007283,spermatogenesis;GO:0016182,synaptic vesicle budding from endosome;GO:0002224,toll-like receptor signaling pathway;GO:0016192,vesicle-mediated transport	hsa:8546,path:hsa04142,Lysosome
PIN1_HUMAN	Q13526	PIN1	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0.557853802	2.121170869	0.026082971	0.017476107	1.3395123355	0.021779539	1.3395123355	0.021779539	61.5032455691555	0.000136	1	0.0162593045415072	0.000132	-1	GO:0036064,ciliary basal body;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0098978,glutamatergic synapse;GO:0030496,midbody;GO:0005739,mitochondrion;GO:0043005,neuron projection;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0099524,postsynaptic cytosol	GO:0008013,beta-catenin binding;GO:0016859,cis-trans isomerase activity;GO:0032794,GTPase activating protein binding;GO:0031434,mitogen-activated protein kinase kinase binding;GO:0003774,motor activity;GO:0003755,peptidyl-prolyl cis-trans isomerase activity;GO:0051219,phosphoprotein binding;GO:0050815,phosphoserine residue binding;GO:0050816,phosphothreonine residue binding;GO:0048156,tau protein binding	GO:0007049,cell cycle;GO:1902430,negative regulation of amyloid-beta formation;GO:2000146,negative regulation of cell motility;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:0043524,negative regulation of neuron apoptotic process;GO:0032091,negative regulation of protein binding;GO:0042177,negative regulation of protein catabolic process;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0032480,negative regulation of type I interferon production;GO:0030182,neuron differentiation;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0061051,positive regulation of cell growth involved in cardiac muscle cell development;GO:0043547,positive regulation of GTPase activity;GO:0043525,positive regulation of neuron apoptotic process;GO:0032092,positive regulation of protein binding;GO:0035307,positive regulation of protein dephosphorylation;GO:0001934,positive regulation of protein phosphorylation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0051443,positive regulation of ubiquitin-protein transferase activity;GO:0000413,protein peptidyl-prolyl isomerization;GO:0050821,protein stabilization;GO:0032465,regulation of cytokinesis;GO:0010468,regulation of gene expression;GO:0007088,regulation of mitotic nuclear division;GO:0060393,regulation of pathway-restricted SMAD protein phosphorylation;GO:1900180,regulation of protein localization to nucleus;GO:0001932,regulation of protein phosphorylation;GO:0031647,regulation of protein stability;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0001666,response to hypoxia;GO:0050808,synapse organization	hsa:5300,path:hsa04622,RIG-I-like receptor signaling pathway
RL27_HUMAN	P61353	RPL27	60S ribosomal protein L27	2.194733134	2.233464518	0.46114827	4.013496592	2.214098826	2.237322431	2.214098826	2.237322431	0.989619911427062	0.436813	0	1.01048896495824	0.436624	0	GO:0098556,cytoplasmic side of rough endoplasmic reticulum membrane;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6155,path:hsa03010,Ribosome
HINT1_HUMAN	P49773	HINT1	Histidine triad nucleotide-binding protein 1	0.64507784	0.671111881	0.711353844	0.478762811	0.6580948605	0.5950583275	0.6580948605	0.5950583275	1.10593336835539	0.400244	0	0.904213606907511	0.399977	0	GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0000118,histone deacetylase complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0043530,adenosine 5'-monophosphoramidase activity;GO:0016787,hydrolase activity;GO:0000166,nucleotide binding;GO:0005080,protein kinase C binding;GO:0003824,catalytic activity	GO:0072332,intrinsic apoptotic signaling pathway by p53 class mediator;GO:0009154,purine ribonucleotide catabolic process;GO:0006355,regulation of transcription, DNA-templated;GO:0007165,signal transduction	
RUSF1_HUMAN	Q96GQ5	RUSF1	RUS family member 1	0.519298424	0.253848419	0.580877257	0.182879601	0.3865734215	0.381878429	0.3865734215	0.381878429	1.01229446898138	0.429303	0	0.987854849198421	0.429098	0	GO:0016021,integral component of membrane;GO:0016020,membrane			
AP2A2_HUMAN	O94973	AP2A2	AP-2 complex subunit alpha-2	5.876692319	9.00650358	10.34631768	33.14375292	7.4415979495	21.7450353	7.4415979495	21.7450353	0.342220550430654	0.091040	0	2.9220921968058	0.091329	0	GO:0030122,AP-2 adaptor complex;GO:0045334,clathrin-coated endocytic vesicle;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0030666,endocytic vesicle membrane;GO:0036020,endolysosome membrane;GO:0101003,ficolin-1-rich granule membrane;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0030117,membrane coat;GO:0030121,AP-1 adaptor complex	GO:0140312,cargo adaptor activity;GO:0035615,clathrin adaptor activity;GO:0097718,disordered domain specific binding;GO:0008289,lipid binding;GO:0019901,protein kinase binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0072583,clathrin-dependent endocytosis;GO:0048013,ephrin receptor signaling pathway;GO:0006886,intracellular protein transport;GO:0034383,low-density lipoprotein particle clearance;GO:0032802,low-density lipoprotein particle receptor catabolic process;GO:0061024,membrane organization;GO:0043312,neutrophil degranulation;GO:0006898,receptor-mediated endocytosis;GO:0050690,regulation of defense response to virus by virus;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0016192,vesicle-mediated transport	hsa:161,path:hsa04144,Endocytosis;hsa:161,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:161,path:hsa04721,Synaptic vesicle cycle;hsa:161,path:hsa05016,Huntington disease
PRTN3_HUMAN	P24158	PRTN3	Myeloblastin	0.135064887	0.416675271	0.203612762	0.569943459	0.275870079	0.3867781105	0.275870079	0.3867781105	0.713251529781182	0.416020	0	1.40202994069538	0.416204	0	GO:0035578,azurophil granule lumen;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043231,intracellular membrane-bounded organelle;GO:0005886,plasma membrane;GO:0044853,plasma membrane raft	GO:0019899,enzyme binding;GO:0004252,serine-type endopeptidase activity;GO:0008236,serine-type peptidase activity;GO:0005102,signaling receptor binding	GO:0019730,antimicrobial humoral response;GO:0007596,blood coagulation;GO:0045217,cell-cell junction maintenance;GO:0030574,collagen catabolic process;GO:0019221,cytokine-mediated signaling pathway;GO:0097029,mature conventional dendritic cell differentiation;GO:0006509,membrane protein ectodomain proteolysis;GO:0050765,negative regulation of phagocytosis;GO:0043312,neutrophil degranulation;GO:0072672,neutrophil extravasation;GO:0006909,phagocytosis;GO:0008284,positive regulation of cell population proliferation;GO:0043547,positive regulation of GTPase activity;GO:0006508,proteolysis	
TIRR_HUMAN	Q9BRJ7	NUDT16L1	Tudor-interacting repair regulator protein	0.370714989	0.183539825	0.03401033	2.55E-05	0.277127407	0.017017915	0.277127407	0.017017915	16.2844512385918	0.005874	1	0.0614082713226556	0.005779	-1	GO:0005634,nucleus	GO:0016787,hydrolase activity;GO:0003723,RNA binding;GO:0030515,snoRNA binding	GO:0016311,dephosphorylation;GO:2001033,negative regulation of double-strand break repair via nonhomologous end joining;GO:0090502,RNA phosphodiester bond hydrolysis, endonucleolytic	hsa:84309,path:hsa05205,Proteoglycans in cancer
ACADV_HUMAN	P49748	ACADVL	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	5.945496847	10.93116462	13.30484093	14.34162221	8.4383307335	13.82323157	8.4383307335	13.82323157	0.61044558870108	0.326375	0	1.63814763921519	0.326643	0	GO:0031314,extrinsic component of mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0031966,mitochondrial membrane;GO:0042645,mitochondrial nucleoid;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005654,nucleoplasm	GO:0003995,acyl-CoA dehydrogenase activity;GO:0000062,fatty-acyl-CoA binding;GO:0050660,flavin adenine dinucleotide binding;GO:0042802,identical protein binding;GO:0004466,long-chain-acyl-CoA dehydrogenase activity;GO:0017099,very-long-chain-acyl-CoA dehydrogenase activity;GO:0016627,oxidoreductase activity, acting on the CH-CH group of donors	GO:0015980,energy derivation by oxidation of organic compounds;GO:0030855,epithelial cell differentiation;GO:0006635,fatty acid beta-oxidation;GO:0033539,fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0036498,IRE1-mediated unfolded protein response;GO:0045717,negative regulation of fatty acid biosynthetic process;GO:0046322,negative regulation of fatty acid oxidation;GO:0090181,regulation of cholesterol metabolic process;GO:0009409,response to cold;GO:0001659,temperature homeostasis	hsa:37,path:hsa00071,Fatty acid degradation
RAD21_HUMAN	O60216	RAD21	Double-strand-break repair protein rad21 homolog	0.160102745	0.132126669	0.26248425	0.244917847	0.146114707	0.2537010485	0.146114707	0.2537010485	0.575932609911937	0.294983	0	1.73631425411543	0.295275	0	GO:0000785,chromatin;GO:0005694,chromosome;GO:0000775,chromosome, centromeric region;GO:0008278,cohesin complex;GO:0005829,cytosol;GO:0016020,membrane;GO:0016363,nuclear matrix;GO:0034991,nuclear meiotic cohesin complex;GO:0034990,nuclear mitotic cohesin complex;GO:0005654,nucleoplasm;GO:0000922,spindle pole;GO:0000795,synaptonemal complex;GO:0005634,nucleus	GO:0003682,chromatin binding	GO:0006915,apoptotic process;GO:0051301,cell division;GO:0006310,DNA recombination;GO:0006302,double-strand break repair;GO:0007064,mitotic sister chromatid cohesion;GO:0007275,multicellular organism development;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0045841,negative regulation of mitotic metaphase/anaphase transition;GO:0045876,positive regulation of sister chromatid cohesion;GO:0071168,protein localization to chromatin;GO:0007131,reciprocal meiotic recombination;GO:0006357,regulation of transcription by RNA polymerase II;GO:1990414,replication-born double-strand break repair via sister chromatid exchange;GO:0007130,synaptonemal complex assembly;GO:0007062,sister chromatid cohesion	hsa:5885,path:hsa04110,Cell cycle
IMPA2_HUMAN	O14732	IMPA2	Inositol monophosphatase 2	0.112846158	0.089077721	0.134227784	2.55E-05	0.1009619395	0.067126642	0.1009619395	0.067126642	1.5040516923221	0.304370	0	0.664870765482868	0.303926	0	GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0008934,inositol monophosphate 1-phosphatase activity;GO:0052832,inositol monophosphate 3-phosphatase activity;GO:0052833,inositol monophosphate 4-phosphatase activity;GO:0046872,metal ion binding;GO:0042803,protein homodimerization activity	GO:0006021,inositol biosynthetic process;GO:0006020,inositol metabolic process;GO:0046855,inositol phosphate dephosphorylation;GO:0043647,inositol phosphate metabolic process;GO:0006796,phosphate-containing compound metabolic process;GO:0046854,phosphatidylinositol phosphorylation;GO:0007165,signal transduction	hsa:3613,path:hsa00562,Inositol phosphate metabolism;hsa:3613,path:hsa04070,Phosphatidylinositol signaling system
B4GT1_HUMAN	P15291	B4GALT1	Beta-1,4-galactosyltransferase 1	0.288506204	0.19400746	0.247874821	0.306325141	0.241256832	0.277099981	0.241256832	0.277099981	0.870649038406105	0.479624	0	1.14856843100717	0.479528	0	GO:0035577,azurophil granule membrane;GO:0016323,basolateral plasma membrane;GO:0031526,brush border membrane;GO:0030057,desmosome;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0030175,filopodium;GO:0005794,Golgi apparatus;GO:0032580,Golgi cisterna membrane;GO:0000139,Golgi membrane;GO:0000138,Golgi trans cisterna;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane	GO:0043014,alpha-tubulin binding;GO:0003831,beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0048487,beta-tubulin binding;GO:0008092,cytoskeletal protein binding;GO:0008378,galactosyltransferase activity;GO:0042802,identical protein binding;GO:0004461,lactose synthase activity;GO:0030145,manganese ion binding;GO:0003945,N-acetyllactosamine synthase activity;GO:0035250,UDP-galactosyltransferase activity;GO:0016757,transferase activity, transferring glycosyl groups	GO:0002526,acute inflammatory response;GO:0060055,angiogenesis involved in wound healing;GO:0007339,binding of sperm to zona pellucida;GO:0007155,cell adhesion;GO:0045136,development of secondary sexual characteristics;GO:0002064,epithelial cell development;GO:0030198,extracellular matrix organization;GO:0006012,galactose metabolic process;GO:0070085,glycosylation;GO:0018146,keratan sulfate biosynthetic process;GO:0005989,lactose biosynthetic process;GO:0050900,leukocyte migration;GO:0008285,negative regulation of cell population proliferation;GO:0043312,neutrophil degranulation;GO:0009312,oligosaccharide biosynthetic process;GO:0007341,penetration of zona pellucida;GO:0043065,positive regulation of apoptotic process;GO:0060054,positive regulation of epithelial cell proliferation involved in wound healing;GO:0006487,protein N-linked glycosylation;GO:0060046,regulation of acrosome reaction;GO:0005975,carbohydrate metabolic process	hsa:2683,path:hsa00052,Galactose metabolism;hsa:2683,path:hsa00510,N-Glycan biosynthesis;hsa:2683,path:hsa00513,Various types of N-glycan biosynthesis;hsa:2683,path:hsa00515,Mannose type O-glycan biosynthesis;hsa:2683,path:hsa00514,Other types of O-glycan biosynthesis;hsa:2683,path:hsa00533,Glycosaminoglycan biosynthesis - keratan sulfate;hsa:2683,path:hsa00601,Glycosphingolipid biosynthesis - lacto and neolacto series
PSPB_HUMAN	P07988	SFTPB	Pulmonary surfactant-associated protein B	0.910058347	2.968690042	16.44338884	9.182995506	1.9393741945	12.813192173	1.9393741945	12.813192173	0.151357613958734	0.004924	-1	6.6068694784832	0.004970	1	GO:0097208,alveolar lamellar body;GO:0045334,clathrin-coated endocytic vesicle;GO:0005789,endoplasmic reticulum membrane;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0042599,lamellar body;GO:0005764,lysosome;GO:0005771,multivesicular body;GO:0097486,multivesicular body lumen		GO:0009887,animal organ morphogenesis;GO:0044267,cellular protein metabolic process;GO:0007585,respiratory gaseous exchange by respiratory system;GO:0006665,sphingolipid metabolic process	
RL21_HUMAN	P46778	RPL21	60S ribosomal protein L21	0.792706568	1.359488506	0.497257024	0.252329154	1.076097537	0.374793089	1.076097537	0.374793089	2.87117764063147	0.145293	0	0.34828914305005	0.144727	0	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0005783,endoplasmic reticulum;GO:0016020,membrane;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6144,path:hsa03010,Ribosome
ERLN2_HUMAN	O94905	ERLIN2	Erlin-2	1.024378633	2.261449946	2.11193051	3.418149627	1.6429142895	2.7650400685	1.6429142895	2.7650400685	0.59417377282032	0.311631	0	1.68300932444961	0.311911	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0045121,membrane raft;GO:0005886,plasma membrane;GO:0032991,protein-containing complex	GO:0015485,cholesterol binding;GO:0031625,ubiquitin protein ligase binding	GO:0008203,cholesterol metabolic process;GO:0045541,negative regulation of cholesterol biosynthetic process;GO:0045717,negative regulation of fatty acid biosynthetic process;GO:0032933,SREBP signaling pathway;GO:0055085,transmembrane transport;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0008202,steroid metabolic process	
AT2A2_HUMAN	P16615	ATP2A2	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	11.35381689	9.055688303	13.81144555	12.91939367	10.2047525965	13.36541961	10.2047525965	13.36541961	0.763519058456258	0.456994	0	1.30972500152371	0.457134	0	GO:0061831,apical ectoplasmic specialization;GO:0090534,calcium ion-transporting ATPase complex;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0005887,integral component of plasma membrane;GO:0014801,longitudinal sarcoplasmic reticulum;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm;GO:0120025,plasma membrane bounded cell projection;GO:0031095,platelet dense tubular network membrane;GO:0032991,protein-containing complex;GO:0097470,ribbon synapse;GO:0016529,sarcoplasmic reticulum;GO:0033017,sarcoplasmic reticulum membrane;GO:0012506,vesicle membrane;GO:0016021,integral component of membrane	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0005509,calcium ion binding;GO:0019899,enzyme binding;GO:0044325,ion channel binding;GO:0031775,lutropin-choriogonadotropic hormone receptor binding;GO:0005388,P-type calcium transporter activity;GO:0086039,P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential;GO:0008553,P-type proton-exporting transporter activity;GO:0008022,protein C-terminus binding;GO:0044548,S100 protein binding;GO:0046872,metal ion binding	GO:0000045,autophagosome assembly;GO:0016240,autophagosome membrane docking;GO:1990036,calcium ion import into sarcoplasmic reticulum;GO:0070588,calcium ion transmembrane transport;GO:1903515,calcium ion transport from cytosol to endoplasmic reticulum;GO:0014898,cardiac muscle hypertrophy in response to stress;GO:0007155,cell adhesion;GO:0006874,cellular calcium ion homeostasis;GO:0034605,cellular response to heat;GO:0034599,cellular response to oxidative stress;GO:0032469,endoplasmic reticulum calcium ion homeostasis;GO:0008544,epidermis development;GO:0006984,ER-nucleus signaling pathway;GO:0034220,ion transmembrane transport;GO:1990456,mitochondrion-endoplasmic reticulum membrane tethering;GO:0045822,negative regulation of heart contraction;GO:1900121,negative regulation of receptor binding;GO:0140056,organelle localization by membrane tethering;GO:0032470,positive regulation of endoplasmic reticulum calcium ion concentration;GO:0010460,positive regulation of heart rate;GO:1903233,regulation of calcium ion-dependent exocytosis of neurotransmitter;GO:1903779,regulation of cardiac conduction;GO:0098909,regulation of cardiac muscle cell action potential involved in regulation of contraction;GO:0086036,regulation of cardiac muscle cell membrane potential;GO:0010882,regulation of cardiac muscle contraction by calcium ion signaling;GO:0002026,regulation of the force of heart contraction;GO:0055119,relaxation of cardiac muscle;GO:0034976,response to endoplasmic reticulum stress;GO:0032496,response to lipopolysaccharide;GO:0070296,sarcoplasmic reticulum calcium ion transport;GO:0003009,skeletal muscle contraction;GO:0033292,T-tubule organization;GO:0014883,transition between fast and slow fiber	hsa:488,path:hsa04020,Calcium signaling pathway;hsa:488,path:hsa04024,cAMP signaling pathway;hsa:488,path:hsa04022,cGMP-PKG signaling pathway;hsa:488,path:hsa04919,Thyroid hormone signaling pathway;hsa:488,path:hsa04260,Cardiac muscle contraction;hsa:488,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:488,path:hsa04972,Pancreatic secretion;hsa:488,path:hsa05010,Alzheimer disease;hsa:488,path:hsa05017,Spinocerebellar ataxia;hsa:488,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:488,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:488,path:hsa05414,Dilated cardiomyopathy (DCM)
CY24B_HUMAN	P04839	CYBB	Cytochrome b-245 heavy chain	1.010849313	1.774741027	2.329085793	1.882281396	1.39279517	2.1056835945	1.39279517	2.1056835945	0.661445610175219	0.371712	0	1.51184010388261	0.371940	0	GO:0030425,dendrite;GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0043020,NADPH oxidase complex;GO:0043025,neuronal cell body;GO:0005635,nuclear envelope;GO:0097038,perinuclear endoplasmic reticulum;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0005791,rough endoplasmic reticulum;GO:0035579,specific granule membrane;GO:0070821,tertiary granule membrane	GO:0050660,flavin adenine dinucleotide binding;GO:0020037,heme binding;GO:0046872,metal ion binding;GO:0046982,protein heterodimerization activity;GO:0016175,superoxide-generating NAD(P)H oxidase activity;GO:0005244,voltage-gated ion channel activity	GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0045454,cell redox homeostasis;GO:0071276,cellular response to cadmium ion;GO:0071361,cellular response to ethanol;GO:1904845,cellular response to L-glutamine;GO:0034599,cellular response to oxidative stress;GO:0006952,defense response;GO:0022900,electron transport chain;GO:0097411,hypoxia-inducible factor-1alpha signaling pathway;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0043312,neutrophil degranulation;GO:0045766,positive regulation of angiogenesis;GO:0032760,positive regulation of tumor necrosis factor production;GO:0034765,regulation of ion transmembrane transport;GO:0045730,respiratory burst;GO:1904044,response to aldosterone;GO:1990776,response to angiotensin;GO:0042493,response to drug;GO:0007584,response to nutrient;GO:0042554,superoxide anion generation;GO:0006801,superoxide metabolic process;GO:0048010,vascular endothelial growth factor receptor signaling pathway	hsa:1536,path:hsa04066,HIF-1 signaling pathway;hsa:1536,path:hsa04145,Phagosome;hsa:1536,path:hsa04216,Ferroptosis;hsa:1536,path:hsa04217,Necroptosis;hsa:1536,path:hsa04621,NOD-like receptor signaling pathway;hsa:1536,path:hsa04670,Leukocyte transendothelial migration;hsa:1536,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:1536,path:hsa05140,Leishmaniasis
HNRPK_HUMAN	P61978	HNRNPK	Heterogeneous nuclear ribonucleoprotein K	18.14924918	34.0449174	22.27035473	23.69007384	26.09708329	22.980214285	26.09708329	22.980214285	1.13563272153796	0.391638	0	0.88056638474253	0.391354	0	GO:0071013,catalytic step 2 spliceosome;GO:0042995,cell projection;GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0002102,podosome;GO:0005681,spliceosomal complex	GO:0045296,cadherin binding;GO:0003677,DNA binding;GO:0042802,identical protein binding;GO:0003729,mRNA binding;GO:0019904,protein domain specific binding;GO:0003723,RNA binding	GO:0000398,mRNA splicing, via spliceosome;GO:0043066,negative regulation of apoptotic process;GO:0048025,negative regulation of mRNA splicing, via spliceosome;GO:1905599,positive regulation of low-density lipoprotein receptor activity;GO:0048260,positive regulation of receptor-mediated endocytosis;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0010468,regulation of gene expression;GO:1902165,regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0010988,regulation of low-density lipoprotein particle clearance;GO:0048024,regulation of mRNA splicing, via spliceosome;GO:0006357,regulation of transcription by RNA polymerase II;GO:0016070,RNA metabolic process;GO:0006396,RNA processing;GO:0007165,signal transduction;GO:0019058,viral life cycle	hsa:3190,path:hsa03040,Spliceosome;hsa:3190,path:hsa05206,MicroRNAs in cancer;hsa:3190,path:hsa05203,Viral carcinogenesis
DUS23_HUMAN	Q9BVJ7	DUSP23	Dual specificity protein phosphatase 23	1.983852894	6.582319692	0.399284486	0.115757449	4.283086293	0.2575209675	4.283086293	0.2575209675	16.6319905310235	0.005584	1	0.0601250943556462	0.005492	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm	GO:0016791,phosphatase activity;GO:0106306,protein serine phosphatase activity;GO:0106307,protein threonine phosphatase activity;GO:0004725,protein tyrosine phosphatase activity;GO:0008138,protein tyrosine/serine/threonine phosphatase activity	GO:0016311,dephosphorylation	
EF1B_HUMAN	P24534	EEF1B2	Elongation factor 1-beta	2.845115944	0.744281279	2.69013888	0.877179618	1.7946986115	1.783659249	1.7946986115	1.783659249	1.00618916561904	0.431306	0	0.993848904529561	0.431105	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005853,eukaryotic translation elongation factor 1 complex	GO:0005085,guanyl-nucleotide exchange factor activity;GO:0003746,translation elongation factor activity	GO:0006414,translational elongation	
TSNAX_HUMAN	Q99598	TSNAX	Translin-associated protein X	0.057731706	0.14819014	0.298982631	2.55E-05	0.102960923	0.1495040655	0.102960923	0.1495040655	0.688683098052608	0.395253	0	1.45204667114338	0.395458	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm	GO:0003677,DNA binding;GO:0004521,endoribonuclease activity;GO:0046872,metal ion binding;GO:0003723,RNA binding;GO:0043565,sequence-specific DNA binding;GO:0031687,A2A adenosine receptor binding;GO:0044877,protein-containing complex binding;GO:0003697,single-stranded DNA binding	GO:0030154,cell differentiation;GO:0007275,multicellular organism development;GO:0030422,production of siRNA involved in RNA interference;GO:0007283,spermatogenesis	
SCMC1_HUMAN	Q6NUK1	SLC25A24	Calcium-binding mitochondrial carrier protein SCaMC-1	1.787964098	3.485163831	3.016220738	3.803539641	2.6365639645	3.4098801895	2.6365639645	3.4098801895	0.773213080218694	0.464649	0	1.2933045567687	0.464780	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion	GO:0005347,ATP transmembrane transporter activity;GO:0005509,calcium ion binding	GO:0015867,ATP transport;GO:0071277,cellular response to calcium ion;GO:0034599,cellular response to oxidative stress;GO:0006839,mitochondrial transport;GO:0010941,regulation of cell death;GO:0055085,transmembrane transport	
ANXA3_HUMAN	P12429	ANXA3	Annexin A3	3.409380889	3.690089767	4.279319132	20.03837003	3.549735328	12.158844581	3.549735328	12.158844581	0.291946763884702	0.057377	0	3.42528201612444	0.057611	0	GO:0030424,axon;GO:0005737,cytoplasm;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0043025,neuronal cell body;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0042581,specific granule	GO:0005509,calcium ion binding;GO:0005544,calcium-dependent phospholipid binding;GO:0048306,calcium-dependent protein binding;GO:0019834,phospholipase A2 inhibitor activity;GO:0004859,phospholipase inhibitor activity	GO:0031100,animal organ regeneration;GO:0042742,defense response to bacterium;GO:0021766,hippocampus development;GO:0043312,neutrophil degranulation;GO:0006909,phagocytosis;GO:0045766,positive regulation of angiogenesis;GO:0051054,positive regulation of DNA metabolic process;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0010595,positive regulation of endothelial cell migration;GO:0051384,response to glucocorticoid;GO:0070848,response to growth factor	
FCSK_HUMAN	Q8N0W3	FCSK	L-fucose kinase	0.157635044	0.115995354	0.142881003	0.046446711	0.136815199	0.094663857	0.136815199	0.094663857	1.44527387046991	0.316228	0	0.691910384898099	0.315803	0	GO:0005829,cytosol	GO:0005524,ATP binding;GO:0050201,fucokinase activity;GO:0016301,kinase activity;GO:0000166,nucleotide binding;GO:0016772,transferase activity, transferring phosphorus-containing groups	GO:0046835,carbohydrate phosphorylation;GO:0042352,GDP-L-fucose salvage;GO:1903350,response to dopamine	hsa:197258,path:hsa00051,Fructose and mannose metabolism;hsa:197258,path:hsa00520,Amino sugar and nucleotide sugar metabolism
CSN4_HUMAN	Q9BT78	COPS4	COP9 signalosome complex subunit 4	1.323325484	0.73743246	1.939670694	1.637040014	1.030378972	1.788355354	1.030378972	1.788355354	0.576160084568964	0.295191	0	1.73562873719049	0.295483	0	GO:0030054,cell junction;GO:0008180,COP9 signalosome;GO:0005829,cytosol;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0008021,synaptic vesicle		GO:0000715,nucleotide-excision repair, DNA damage recognition;GO:0043687,post-translational protein modification;GO:0000338,protein deneddylation;GO:0006283,transcription-coupled nucleotide-excision repair	
CLIC5_HUMAN	Q9NZA1	CLIC5	Chloride intracellular channel protein 5	0.082810357	0.042789946	0.048122913	0.304816125	0.0628001515	0.176469519	0.0628001515	0.176469519	0.355869681381066	0.101224	0	2.81001740895482	0.101524	0	GO:0015629,actin cytoskeleton;GO:0016324,apical plasma membrane;GO:0005938,cell cortex;GO:0034707,chloride channel complex;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0005815,microtubule organizing center;GO:0005737,cytoplasm	GO:0005254,chloride channel activity;GO:0005244,voltage-gated ion channel activity	GO:0006821,chloride transport;GO:0007565,female pregnancy;GO:0006749,glutathione metabolic process;GO:0034765,regulation of ion transmembrane transport;GO:0050896,response to stimulus;GO:0007605,sensory perception of sound;GO:0007601,visual perception	
ANGT_HUMAN	P01019	AGT	Angiotensinogen	0.64662676	0.298507485	1.797455417	10.25651502	0.4725671225	6.0269852185	0.4725671225	6.0269852185	0.0784085418111599	0.000168	-1	12.7537125025028	0.000171	1	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0008083,growth factor activity;GO:0005179,hormone activity;GO:0048018,receptor ligand activity;GO:0004867,serine-type endopeptidase inhibitor activity;GO:0017080,sodium channel regulator activity;GO:0016176,superoxide-generating NADPH oxidase activator activity;GO:0031702,type 1 angiotensin receptor binding;GO:0031703,type 2 angiotensin receptor binding	GO:0000187,activation of MAPK activity;GO:0038166,angiotensin-activated signaling pathway;GO:0001974,blood vessel remodeling;GO:0007267,cell-cell signaling;GO:0007186,G protein-coupled receptor signaling pathway;GO:0007199,G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger;GO:0001822,kidney development;GO:0034374,low-density lipoprotein particle remodeling;GO:0002034,maintenance of blood vessel diameter homeostasis by renin-angiotensin;GO:0010951,negative regulation of endopeptidase activity;GO:0010629,negative regulation of gene expression;GO:0043407,negative regulation of MAP kinase activity;GO:0051387,negative regulation of neurotrophin TRK receptor signaling pathway;GO:2000650,negative regulation of sodium ion transmembrane transporter activity;GO:0007263,nitric oxide mediated signal transduction;GO:0007200,phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0010536,positive regulation of activation of Janus kinase activity;GO:0090190,positive regulation of branching involved in ureteric bud morphogenesis;GO:0010613,positive regulation of cardiac muscle hypertrophy;GO:0032270,positive regulation of cellular protein metabolic process;GO:0010873,positive regulation of cholesterol esterification;GO:0001819,positive regulation of cytokine production;GO:0010595,positive regulation of endothelial cell migration;GO:0045742,positive regulation of epidermal growth factor receptor signaling pathway;GO:2001238,positive regulation of extrinsic apoptotic signaling pathway;GO:0048146,positive regulation of fibroblast proliferation;GO:1903598,positive regulation of gap junction assembly;GO:0050729,positive regulation of inflammatory response;GO:0010744,positive regulation of macrophage derived foam cell differentiation;GO:1902632,positive regulation of membrane hyperpolarization;GO:0033864,positive regulation of NAD(P)H oxidase activity;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0014068,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0061098,positive regulation of protein tyrosine kinase activity;GO:2000379,positive regulation of reactive oxygen species metabolic process;GO:0045893,positive regulation of transcription, DNA-templated;GO:0008217,regulation of blood pressure;GO:0002016,regulation of blood volume by renin-angiotensin;GO:1903779,regulation of cardiac conduction;GO:0001558,regulation of cell growth;GO:0042127,regulation of cell population proliferation;GO:1901201,regulation of extracellular matrix assembly;GO:0019222,regulation of metabolic process;GO:0002019,regulation of renal output by angiotensin;GO:0035813,regulation of renal sodium excretion;GO:0019229,regulation of vasoconstriction;GO:0003014,renal system process;GO:0002018,renin-angiotensin regulation of aldosterone production;GO:0014873,response to muscle activity involved in regulation of muscle adaptation;GO:0042310,vasoconstriction	
WDR18_HUMAN	Q9BV38	WDR18	WD repeat-containing protein 18	0.363693695	0.156811314	0.321135624	0.167115629	0.2602525045	0.2441256265	0.2602525045	0.2441256265	1.06605975059321	0.412248	0	0.938033726011655	0.412006	0	GO:0120293,dynein axonemal particle;GO:0005656,nuclear pre-replicative complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0097344,Rix1 complex		GO:0007275,multicellular organism development;GO:0030174,regulation of DNA-dependent DNA replication initiation;GO:0006364,rRNA processing	
LTOR1_HUMAN	Q6IAA8	LAMTOR1	Ragulator complex protein LAMTOR1	0.485810716	6.160515232	0.08230835	0.020383686	3.323162974	0.051346018	3.323162974	0.051346018	64.7209482534751	0.000115	1	0.0154509479076785	0.000112	-1	GO:0035577,azurophil granule membrane;GO:0070062,extracellular exosome;GO:0101003,ficolin-1-rich granule membrane;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0045121,membrane raft;GO:0005886,plasma membrane;GO:0071986,Ragulator complex;GO:0035579,specific granule membrane	GO:0051020,GTPase binding	GO:0007050,cell cycle arrest;GO:0034613,cellular protein localization;GO:0034198,cellular response to amino acid starvation;GO:0071230,cellular response to amino acid stimulus;GO:0042632,cholesterol homeostasis;GO:0016197,endosomal transport;GO:0007032,endosome organization;GO:0032418,lysosome localization;GO:0007040,lysosome organization;GO:0043312,neutrophil degranulation;GO:0043410,positive regulation of MAPK cascade;GO:0032008,positive regulation of TOR signaling;GO:0050790,regulation of catalytic activity;GO:0001558,regulation of cell growth;GO:0010874,regulation of cholesterol efflux;GO:0010872,regulation of cholesterol esterification;GO:0060620,regulation of cholesterol import;GO:0016241,regulation of macroautophagy;GO:0001919,regulation of receptor recycling	hsa:55004,path:hsa04150,mTOR signaling pathway
MTA2_HUMAN	O94776	MTA2	Metastasis-associated protein MTA2	0.326935214	0.192205238	0.479061096	0.904405905	0.259570226	0.6917335005	0.259570226	0.6917335005	0.375245995477127	0.116320	0	2.66491851226419	0.116633	0	GO:0000785,chromatin;GO:0000118,histone deacetylase complex;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0016581,NuRD complex;GO:0032991,protein-containing complex;GO:0005667,transcription regulator complex	GO:0003682,chromatin binding;GO:0004407,histone deacetylase activity;GO:0042826,histone deacetylase binding;GO:0001103,RNA polymerase II repressing transcription factor binding;GO:0001085,RNA polymerase II transcription factor binding;GO:0043565,sequence-specific DNA binding;GO:0003713,transcription coactivator activity;GO:0003714,transcription corepressor activity;GO:0008270,zinc ion binding	GO:0043044,ATP-dependent chromatin remodeling;GO:0006333,chromatin assembly or disassembly;GO:0006306,DNA methylation;GO:0016575,histone deacetylation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0010762,regulation of fibroblast migration;GO:1901796,regulation of signal transduction by p53 class mediator	
WDR11_HUMAN	Q9BZH6	WDR11	WD repeat-containing protein 11	0.184285179	0.057596787	0.21494882	0.302886316	0.120940983	0.258917568	0.120940983	0.258917568	0.46710226708139	0.195182	0	2.14085880218123	0.195517	0	GO:0005930,axoneme;GO:0036064,ciliary basal body;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0015630,microtubule cytoskeleton;GO:0005634,nucleus;GO:0005802,trans-Golgi network		GO:0060271,cilium assembly;GO:0060322,head development;GO:0007507,heart development;GO:0006886,intracellular protein transport;GO:0035264,multicellular organism growth;GO:0008589,regulation of smoothened signaling pathway;GO:0099041,vesicle tethering to Golgi	
SPB8_HUMAN	P50452	SERPINB8	Serpin B8	0.905271472	1.117127567	1.714966799	0.510878897	1.0111995195	1.112922848	1.0111995195	1.112922848	0.90859804102072	0.465313	0	1.10059669386542	0.465185	0	GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space	GO:0004867,serine-type endopeptidase inhibitor activity	GO:0090136,epithelial cell-cell adhesion;GO:0010951,negative regulation of endopeptidase activity	
NADE_HUMAN	Q6IA69	NADSYN1	Glutamine-dependent NAD(+) synthetase	0.087873208	0.090147637	0.161952958	0.157947252	0.0890104225	0.159950105	0.0890104225	0.159950105	0.556488678141224	0.277136	0	1.79698175233355	0.277440	0	GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0005524,ATP binding;GO:0004359,glutaminase activity;GO:0003952,NAD+ synthase (glutamine-hydrolyzing) activity	GO:0034627,'de novo' NAD biosynthetic process;GO:0009435,NAD biosynthetic process;GO:0019674,NAD metabolic process	hsa:55191,path:hsa00760,Nicotinate and nicotinamide metabolism
NDUF3_HUMAN	Q9BU61	NDUFAF3	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3	1.111565727	2.008288329	0.111297174	0.050668663	1.559927028	0.0809829185	1.559927028	0.0809829185	19.2624204819193	0.003893	1	0.0519145556467658	0.003824	-1	GO:0005743,mitochondrial inner membrane;GO:0005634,nucleus		GO:0032981,mitochondrial respiratory chain complex I assembly	hsa:25915,path:hsa04714,Thermogenesis
PO210_HUMAN	Q8TEM1	NUP210	Nuclear pore membrane glycoprotein 210	1.271748066	1.293739776	2.694594038	1.480613968	1.282743921	2.087604003	1.282743921	2.087604003	0.614457492492172	0.329992	0	1.62745187782496	0.330258	0	GO:0005789,endoplasmic reticulum membrane;GO:0043657,host cell;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0005643,nuclear pore		GO:0075733,intracellular transport of virus;GO:0006406,mRNA export from nucleus;GO:0016925,protein sumoylation;GO:0065003,protein-containing complex assembly;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription	hsa:23225,path:hsa03013,RNA transport
SRP14_HUMAN	P37108	SRP14	Signal recognition particle 14 kDa protein	2.817127585	3.301115135	0.091134545	0.008706486	3.05912136	0.0499205155	3.05912136	0.0499205155	61.2798431538633	0.000138	1	0.0163185796264062	0.000134	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005634,nucleus;GO:0034774,secretory granule lumen;GO:0005786,signal recognition particle, endoplasmic reticulum targeting	GO:0008312,7S RNA binding;GO:0030942,endoplasmic reticulum signal peptide binding;GO:0003723,RNA binding	GO:0006613,cotranslational protein targeting to membrane;GO:0043312,neutrophil degranulation;GO:0045047,protein targeting to ER;GO:0006614,SRP-dependent cotranslational protein targeting to membrane	hsa:6727,path:hsa03060,Protein export
AAKG1_HUMAN	P54619	PRKAG1	5'-AMP-activated protein kinase subunit gamma-1	1.212782703	1.854261758	2.571219948	15.81487054	1.5335222305	9.193045244	1.5335222305	9.193045244	0.166813301772977	0.007497	-1	5.99472577649079	0.007560	1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0031588,nucleotide-activated protein kinase complex;GO:0005634,nucleus	GO:0043531,ADP binding;GO:0016208,AMP binding;GO:0005524,ATP binding;GO:0004691,cAMP-dependent protein kinase activity;GO:0008603,cAMP-dependent protein kinase regulator activity;GO:0004672,protein kinase activity;GO:0019901,protein kinase binding;GO:0019887,protein kinase regulator activity;GO:0032559,adenyl ribonucleotide binding	GO:0007050,cell cycle arrest;GO:0042149,cellular response to glucose starvation;GO:0006633,fatty acid biosynthetic process;GO:0051170,import into nucleus;GO:0016236,macroautophagy;GO:0010628,positive regulation of gene expression;GO:0045860,positive regulation of protein kinase activity;GO:0006468,protein phosphorylation;GO:0050790,regulation of catalytic activity;GO:0006110,regulation of glycolytic process;GO:0016241,regulation of macroautophagy;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0007165,signal transduction;GO:0007283,spermatogenesis;GO:0071900,regulation of protein serine/threonine kinase activity	hsa:5571,path:hsa04371,Apelin signaling pathway;hsa:5571,path:hsa04068,FoxO signaling pathway;hsa:5571,path:hsa04152,AMPK signaling pathway;hsa:5571,path:hsa04530,Tight junction;hsa:5571,path:hsa04910,Insulin signaling pathway;hsa:5571,path:hsa04922,Glucagon signaling pathway;hsa:5571,path:hsa04920,Adipocytokine signaling pathway;hsa:5571,path:hsa04921,Oxytocin signaling pathway;hsa:5571,path:hsa04211,Longevity regulating pathway;hsa:5571,path:hsa04213,Longevity regulating pathway - multiple species;hsa:5571,path:hsa04710,Circadian rhythm;hsa:5571,path:hsa04714,Thermogenesis;hsa:5571,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:5571,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:5571,path:hsa04931,Insulin resistance
DQA2_HUMAN	P01906	HLA-DQA2	HLA class II histocompatibility antigen, DQ alpha 2 chain	2.55E-05	0.086136604	0.13638246	2.55E-05	0.043081052	0.06820398	0.043081052	0.06820398	0.63165011777905	0.345403	0	1.58315493317108	0.345655	0	GO:0009986,cell surface;GO:0031901,early endosome membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0000139,Golgi membrane;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0042612,MHC class I protein complex;GO:0032398,MHC class Ib protein complex;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0030667,secretory granule membrane;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0030666,endocytic vesicle membrane;GO:0001772,immunological synapse;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0042613,MHC class II protein complex;GO:0032588,trans-Golgi network membrane;GO:0030658,transport vesicle membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0010008,endosome membrane;GO:0005882,intermediate filament;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0005797,Golgi medial cisterna;GO:0042824,MHC class I peptide loading complex;GO:0035577,azurophil granule membrane;GO:0033106,cis-Golgi network membrane;GO:0005769,early endosome;GO:0031527,filopodium membrane;GO:0005771,multivesicular body	GO:0030881,beta-2-microglobulin binding;GO:0042288,MHC class I protein binding;GO:0046703,natural killer cell lectin-like receptor binding;GO:0042605,peptide antigen binding;GO:0005102,signaling receptor binding;GO:0042608,T cell receptor binding;GO:0051087,chaperone binding;GO:0046977,TAP binding;GO:0023026,MHC class II protein complex binding;GO:0032395,MHC class II receptor activity;GO:0030247,polysaccharide binding;GO:0042609,CD4 receptor binding;GO:0005200,structural constituent of cytoskeleton;GO:0042610,CD8 receptor binding;GO:0003723,RNA binding;GO:0062061,TAP complex binding;GO:0071889,14-3-3 protein binding;GO:0046978,TAP1 binding;GO:0046979,TAP2 binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:1990405,protein antigen binding;GO:0015643,toxic substance binding;GO:0008134,transcription factor binding;GO:0031625,ubiquitin protein ligase binding;GO:0046872,metal ion binding	GO:0002250,adaptive immune response;GO:0019731,antibacterial humoral response;GO:0002476,antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0002477,antigen processing and presentation of exogenous peptide antigen via MHC class Ib;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0036037,CD8-positive, alpha-beta T cell activation;GO:0050830,defense response to Gram-positive bacterium;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0002519,natural killer cell tolerance induction;GO:0045953,negative regulation of natural killer cell mediated cytotoxicity;GO:0001815,positive regulation of antibody-dependent cellular cytotoxicity;GO:2001187,positive regulation of CD8-positive, alpha-beta T cell activation;GO:2000566,positive regulation of CD8-positive, alpha-beta T cell proliferation;GO:0002639,positive regulation of immunoglobulin production;GO:0032736,positive regulation of interleukin-13 production;GO:0032753,positive regulation of interleukin-4 production;GO:0002729,positive regulation of natural killer cell cytokine production;GO:0045954,positive regulation of natural killer cell mediated cytotoxicity;GO:0002717,positive regulation of natural killer cell mediated immunity;GO:0032819,positive regulation of natural killer cell proliferation;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:0032759,positive regulation of TRAIL production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0042270,protection from natural killer cell mediated cytotoxicity;GO:0050776,regulation of immune response;GO:0002715,regulation of natural killer cell mediated immunity;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process;GO:0002486,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006952,defense response;GO:0016045,detection of bacterium;GO:0006955,immune response;GO:0043312,neutrophil degranulation;GO:2001198,regulation of dendritic cell differentiation;GO:0032655,regulation of interleukin-12 production;GO:0032675,regulation of interleukin-6 production;GO:0002667,regulation of T cell anergy;GO:0002491,antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002504,antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0050890,cognition;GO:0002469,myeloid dendritic cell antigen processing and presentation;GO:0002503,peptide antigen assembly with MHC class II protein complex;GO:2000516,positive regulation of CD4-positive, alpha-beta T cell activation;GO:0032831,positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0043382,positive regulation of memory T cell differentiation;GO:0045622,regulation of T-helper cell differentiation;GO:0050852,T cell receptor signaling pathway;GO:0002399,MHC class II protein complex assembly;GO:2001190,positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0042102,positive regulation of T cell proliferation;GO:0032729,positive regulation of interferon-gamma production;GO:0050870,positive regulation of T cell activation;GO:0008544,epidermis development;GO:0006959,humoral immune response;GO:0002437,inflammatory response to antigenic stimulus;GO:0030225,macrophage differentiation;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0032689,negative regulation of interferon-gamma production;GO:0042130,negative regulation of T cell proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0033674,positive regulation of kinase activity;GO:0043410,positive regulation of MAPK cascade;GO:0045657,positive regulation of monocyte differentiation;GO:0001934,positive regulation of protein phosphorylation;GO:0002842,positive regulation of T cell mediated immune response to tumor cell;GO:0045893,positive regulation of transcription, DNA-templated;GO:0046598,positive regulation of viral entry into host cell;GO:0051262,protein tetramerization;GO:0032653,regulation of interleukin-10 production;GO:0032673,regulation of interleukin-4 production;GO:0007165,signal transduction;GO:0042088,T-helper 1 type immune response;GO:0002587,negative regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0045580,regulation of T cell differentiation;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002485,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent;GO:0042590,antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:2000568,positive regulation of memory T cell activation;GO:0002726,positive regulation of T cell cytokine production;GO:0016567,protein ubiquitination;GO:0001913,T cell mediated cytotoxicity;GO:0002419,T cell mediated cytotoxicity directed against tumor cell target;GO:0002728,negative regulation of natural killer cell cytokine production;GO:0043322,negative regulation of natural killer cell degranulation;GO:1901215,negative regulation of neuron death;GO:0002725,negative regulation of T cell cytokine production;GO:0043323,positive regulation of natural killer cell degranulation;GO:0071346,cellular response to interferon-gamma;GO:0006968,cellular defense response;GO:0002767,immune response-inhibiting cell surface receptor signaling pathway;GO:0016525,negative regulation of angiogenesis;GO:2001199,negative regulation of dendritic cell differentiation;GO:0070317,negative regulation of G0 to G1 transition;GO:0050777,negative regulation of immune response;GO:0051898,negative regulation of protein kinase B signaling;GO:0001915,negative regulation of T cell mediated cytotoxicity;GO:0002451,peripheral B cell tolerance induction;GO:2000774,positive regulation of cellular senescence;GO:2000353,positive regulation of endothelial cell apoptotic process;GO:0032735,positive regulation of interleukin-12 production;GO:0060907,positive regulation of macrophage cytokine production;GO:0045591,positive regulation of regulatory T cell differentiation;GO:0002666,positive regulation of T cell tolerance induction;GO:0002645,positive regulation of tolerance induction;GO:0070207,protein homotrimerization;GO:0019882,antigen processing and presentation;GO:0002344,B cell affinity maturation;GO:0046635,positive regulation of alpha-beta T cell activation;GO:0002579,positive regulation of antigen processing and presentation;GO:0002827,positive regulation of T-helper 1 type immune response	hsa:3133,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3133,path:hsa04144,Endocytosis;hsa:3133,path:hsa04145,Phagosome;hsa:3133,path:hsa04218,Cellular senescence;hsa:3133,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3133,path:hsa04612,Antigen processing and presentation;hsa:3133,path:hsa05203,Viral carcinogenesis;hsa:3133,path:hsa05320,Autoimmune thyroid disease;hsa:3133,path:hsa05330,Allograft rejection;hsa:3133,path:hsa05332,Graft-versus-host disease;hsa:3133,path:hsa05416,Viral myocarditis;hsa:3133,path:hsa04940,Type I diabetes mellitus;hsa:3133,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3133,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3133,path:hsa05168,Herpes simplex virus 1 infection;hsa:3133,path:hsa05163,Human cytomegalovirus infection;hsa:3133,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3133,path:hsa05169,Epstein-Barr virus infection;hsa:3133,path:hsa05165,Human papillomavirus infection;hsa:3106,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3106,path:hsa04144,Endocytosis;hsa:3106,path:hsa04145,Phagosome;hsa:3106,path:hsa04218,Cellular senescence;hsa:3106,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3106,path:hsa04612,Antigen processing and presentation;hsa:3106,path:hsa05203,Viral carcinogenesis;hsa:3106,path:hsa05320,Autoimmune thyroid disease;hsa:3106,path:hsa05330,Allograft rejection;hsa:3106,path:hsa05332,Graft-versus-host disease;hsa:3106,path:hsa05416,Viral myocarditis;hsa:3106,path:hsa04940,Type I diabetes mellitus;hsa:3106,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3106,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3106,path:hsa05168,Herpes simplex virus 1 infection;hsa:3106,path:hsa05163,Human cytomegalovirus infection;hsa:3106,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3106,path:hsa05169,Epstein-Barr virus infection;hsa:3106,path:hsa05165,Human papillomavirus infection;hsa:3122,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3122,path:hsa04145,Phagosome;hsa:3122,path:hsa04640,Hematopoietic cell lineage;hsa:3122,path:hsa04612,Antigen processing and presentation;hsa:3122,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3122,path:hsa04659,Th17 cell differentiation;hsa:3122,path:hsa04672,Intestinal immune network for IgA production;hsa:3122,path:hsa05310,Asthma;hsa:3122,path:hsa05322,Systemic lupus erythematosus;hsa:3122,path:hsa05323,Rheumatoid arthritis;hsa:3122,path:hsa05320,Autoimmune thyroid disease;hsa:3122,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3122,path:hsa05330,Allograft rejection;hsa:3122,path:hsa05332,Graft-versus-host disease;hsa:3122,path:hsa05416,Viral myocarditis;hsa:3122,path:hsa04940,Type I diabetes mellitus;hsa:3122,path:hsa05150,Staphylococcus aureus infection;hsa:3122,path:hsa05152,Tuberculosis;hsa:3122,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3122,path:hsa05164,Influenza A;hsa:3122,path:hsa05168,Herpes simplex virus 1 infection;hsa:3122,path:hsa05169,Epstein-Barr virus infection;hsa:3122,path:hsa05145,Toxoplasmosis;hsa:3122,path:hsa05140,Leishmaniasis;hsa:3109,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3109,path:hsa04145,Phagosome;hsa:3109,path:hsa04640,Hematopoietic cell lineage;hsa:3109,path:hsa04612,Antigen processing and presentation;hsa:3109,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3109,path:hsa04659,Th17 cell differentiation;hsa:3109,path:hsa04672,Intestinal immune network for IgA production;hsa:3109,path:hsa05310,Asthma;hsa:3109,path:hsa05322,Systemic lupus erythematosus;hsa:3109,path:hsa05323,Rheumatoid arthritis;hsa:3109,path:hsa05320,Autoimmune thyroid disease;hsa:3109,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3109,path:hsa05330,Allograft rejection;hsa:3109,path:hsa05332,Graft-versus-host disease;hsa:3109,path:hsa05416,Viral myocarditis;hsa:3109,path:hsa04940,Type I diabetes mellitus;hsa:3109,path:hsa05150,Staphylococcus aureus infection;hsa:3109,path:hsa05152,Tuberculosis;hsa:3109,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3109,path:hsa05164,Influenza A;hsa:3109,path:hsa05168,Herpes simplex virus 1 infection;hsa:3109,path:hsa05169,Epstein-Barr virus infection;hsa:3109,path:hsa05145,Toxoplasmosis;hsa:3109,path:hsa05140,Leishmaniasis;hsa:3115,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3115,path:hsa04145,Phagosome;hsa:3115,path:hsa04640,Hematopoietic cell lineage;hsa:3115,path:hsa04612,Antigen processing and presentation;hsa:3115,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3115,path:hsa04659,Th17 cell differentiation;hsa:3115,path:hsa04672,Intestinal immune network for IgA production;hsa:3115,path:hsa05310,Asthma;hsa:3115,path:hsa05322,Systemic lupus erythematosus;hsa:3115,path:hsa05323,Rheumatoid arthritis;hsa:3115,path:hsa05320,Autoimmune thyroid disease;hsa:3115,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3115,path:hsa05330,Allograft rejection;hsa:3115,path:hsa05332,Graft-versus-host disease;hsa:3115,path:hsa05416,Viral myocarditis;hsa:3115,path:hsa04940,Type I diabetes mellitus;hsa:3115,path:hsa05150,Staphylococcus aureus infection;hsa:3115,path:hsa05152,Tuberculosis;hsa:3115,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3115,path:hsa05164,Influenza A;hsa:3115,path:hsa05168,Herpes simplex virus 1 infection;hsa:3115,path:hsa05169,Epstein-Barr virus infection;hsa:3115,path:hsa05145,Toxoplasmosis;hsa:3115,path:hsa05140,Leishmaniasis;hsa:3123,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3123,path:hsa04145,Phagosome;hsa:3123,path:hsa04640,Hematopoietic cell lineage;hsa:3123,path:hsa04612,Antigen processing and presentation;hsa:3123,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3123,path:hsa04659,Th17 cell differentiation;hsa:3123,path:hsa04672,Intestinal immune network for IgA production;hsa:3123,path:hsa05310,Asthma;hsa:3123,path:hsa05322,Systemic lupus erythematosus;hsa:3123,path:hsa05323,Rheumatoid arthritis;hsa:3123,path:hsa05320,Autoimmune thyroid disease;hsa:3123,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3123,path:hsa05330,Allograft rejection;hsa:3123,path:hsa05332,Graft-versus-host disease;hsa:3123,path:hsa05416,Viral myocarditis;hsa:3123,path:hsa04940,Type I diabetes mellitus;hsa:3123,path:hsa05150,Staphylococcus aureus infection;hsa:3123,path:hsa05152,Tuberculosis;hsa:3123,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3123,path:hsa05164,Influenza A;hsa:3123,path:hsa05168,Herpes simplex virus 1 infection;hsa:3123,path:hsa05169,Epstein-Barr virus infection;hsa:3123,path:hsa05145,Toxoplasmosis;hsa:3123,path:hsa05140,Leishmaniasis;hsa:3111,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3111,path:hsa04145,Phagosome;hsa:3111,path:hsa04640,Hematopoietic cell lineage;hsa:3111,path:hsa04612,Antigen processing and presentation;hsa:3111,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3111,path:hsa04659,Th17 cell differentiation;hsa:3111,path:hsa04672,Intestinal immune network for IgA production;hsa:3111,path:hsa05310,Asthma;hsa:3111,path:hsa05322,Systemic lupus erythematosus;hsa:3111,path:hsa05323,Rheumatoid arthritis;hsa:3111,path:hsa05320,Autoimmune thyroid disease;hsa:3111,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3111,path:hsa05330,Allograft rejection;hsa:3111,path:hsa05332,Graft-versus-host disease;hsa:3111,path:hsa05416,Viral myocarditis;hsa:3111,path:hsa04940,Type I diabetes mellitus;hsa:3111,path:hsa05150,Staphylococcus aureus infection;hsa:3111,path:hsa05152,Tuberculosis;hsa:3111,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3111,path:hsa05164,Influenza A;hsa:3111,path:hsa05168,Herpes simplex virus 1 infection;hsa:3111,path:hsa05169,Epstein-Barr virus infection;hsa:3111,path:hsa05145,Toxoplasmosis;hsa:3111,path:hsa05140,Leishmaniasis;hsa:3112,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3112,path:hsa04145,Phagosome;hsa:3112,path:hsa04640,Hematopoietic cell lineage;hsa:3112,path:hsa04612,Antigen processing and presentation;hsa:3112,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3112,path:hsa04659,Th17 cell differentiation;hsa:3112,path:hsa04672,Intestinal immune network for IgA production;hsa:3112,path:hsa05310,Asthma;hsa:3112,path:hsa05322,Systemic lupus erythematosus;hsa:3112,path:hsa05323,Rheumatoid arthritis;hsa:3112,path:hsa05320,Autoimmune thyroid disease;hsa:3112,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3112,path:hsa05330,Allograft rejection;hsa:3112,path:hsa05332,Graft-versus-host disease;hsa:3112,path:hsa05416,Viral myocarditis;hsa:3112,path:hsa04940,Type I diabetes mellitus;hsa:3112,path:hsa05150,Staphylococcus aureus infection;hsa:3112,path:hsa05152,Tuberculosis;hsa:3112,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3112,path:hsa05164,Influenza A;hsa:3112,path:hsa05168,Herpes simplex virus 1 infection;hsa:3112,path:hsa05169,Epstein-Barr virus infection;hsa:3112,path:hsa05145,Toxoplasmosis;hsa:3112,path:hsa05140,Leishmaniasis;hsa:3105,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3105,path:hsa04144,Endocytosis;hsa:3105,path:hsa04145,Phagosome;hsa:3105,path:hsa04218,Cellular senescence;hsa:3105,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3105,path:hsa04612,Antigen processing and presentation;hsa:3105,path:hsa05203,Viral carcinogenesis;hsa:3105,path:hsa05320,Autoimmune thyroid disease;hsa:3105,path:hsa05330,Allograft rejection;hsa:3105,path:hsa05332,Graft-versus-host disease;hsa:3105,path:hsa05416,Viral myocarditis;hsa:3105,path:hsa04940,Type I diabetes mellitus;hsa:3105,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3105,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3105,path:hsa05168,Herpes simplex virus 1 infection;hsa:3105,path:hsa05163,Human cytomegalovirus infection;hsa:3105,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3105,path:hsa05169,Epstein-Barr virus infection;hsa:3105,path:hsa05165,Human papillomavirus infection;hsa:3134,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3134,path:hsa04144,Endocytosis;hsa:3134,path:hsa04145,Phagosome;hsa:3134,path:hsa04218,Cellular senescence;hsa:3134,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3134,path:hsa04612,Antigen processing and presentation;hsa:3134,path:hsa05203,Viral carcinogenesis;hsa:3134,path:hsa05320,Autoimmune thyroid disease;hsa:3134,path:hsa05330,Allograft rejection;hsa:3134,path:hsa05332,Graft-versus-host disease;hsa:3134,path:hsa05416,Viral myocarditis;hsa:3134,path:hsa04940,Type I diabetes mellitus;hsa:3134,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3134,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3134,path:hsa05168,Herpes simplex virus 1 infection;hsa:3134,path:hsa05163,Human cytomegalovirus infection;hsa:3134,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3134,path:hsa05169,Epstein-Barr virus infection;hsa:3134,path:hsa05165,Human papillomavirus infection;hsa:3119,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3119,path:hsa04145,Phagosome;hsa:3119,path:hsa04640,Hematopoietic cell lineage;hsa:3119,path:hsa04612,Antigen processing and presentation;hsa:3119,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3119,path:hsa04659,Th17 cell differentiation;hsa:3119,path:hsa04672,Intestinal immune network for IgA production;hsa:3119,path:hsa05310,Asthma;hsa:3119,path:hsa05322,Systemic lupus erythematosus;hsa:3119,path:hsa05323,Rheumatoid arthritis;hsa:3119,path:hsa05320,Autoimmune thyroid disease;hsa:3119,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3119,path:hsa05330,Allograft rejection;hsa:3119,path:hsa05332,Graft-versus-host disease;hsa:3119,path:hsa05416,Viral myocarditis;hsa:3119,path:hsa04940,Type I diabetes mellitus;hsa:3119,path:hsa05150,Staphylococcus aureus infection;hsa:3119,path:hsa05152,Tuberculosis;hsa:3119,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3119,path:hsa05164,Influenza A;hsa:3119,path:hsa05168,Herpes simplex virus 1 infection;hsa:3119,path:hsa05169,Epstein-Barr virus infection;hsa:3119,path:hsa05145,Toxoplasmosis;hsa:3119,path:hsa05140,Leishmaniasis;hsa:3113,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3113,path:hsa04145,Phagosome;hsa:3113,path:hsa04640,Hematopoietic cell lineage;hsa:3113,path:hsa04612,Antigen processing and presentation;hsa:3113,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3113,path:hsa04659,Th17 cell differentiation;hsa:3113,path:hsa04672,Intestinal immune network for IgA production;hsa:3113,path:hsa05310,Asthma;hsa:3113,path:hsa05322,Systemic lupus erythematosus;hsa:3113,path:hsa05323,Rheumatoid arthritis;hsa:3113,path:hsa05320,Autoimmune thyroid disease;hsa:3113,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3113,path:hsa05330,Allograft rejection;hsa:3113,path:hsa05332,Graft-versus-host disease;hsa:3113,path:hsa05416,Viral myocarditis;hsa:3113,path:hsa04940,Type I diabetes mellitus;hsa:3113,path:hsa05150,Staphylococcus aureus infection;hsa:3113,path:hsa05152,Tuberculosis;hsa:3113,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3113,path:hsa05164,Influenza A;hsa:3113,path:hsa05168,Herpes simplex virus 1 infection;hsa:3113,path:hsa05169,Epstein-Barr virus infection;hsa:3113,path:hsa05145,Toxoplasmosis;hsa:3113,path:hsa05140,Leishmaniasis;hsa:3125,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3125,path:hsa04145,Phagosome;hsa:3125,path:hsa04640,Hematopoietic cell lineage;hsa:3125,path:hsa04612,Antigen processing and presentation;hsa:3125,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3125,path:hsa04659,Th17 cell differentiation;hsa:3125,path:hsa04672,Intestinal immune network for IgA production;hsa:3125,path:hsa05310,Asthma;hsa:3125,path:hsa05322,Systemic lupus erythematosus;hsa:3125,path:hsa05323,Rheumatoid arthritis;hsa:3125,path:hsa05320,Autoimmune thyroid disease;hsa:3125,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3125,path:hsa05330,Allograft rejection;hsa:3125,path:hsa05332,Graft-versus-host disease;hsa:3125,path:hsa05416,Viral myocarditis;hsa:3125,path:hsa04940,Type I diabetes mellitus;hsa:3125,path:hsa05150,Staphylococcus aureus infection;hsa:3125,path:hsa05152,Tuberculosis;hsa:3125,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3125,path:hsa05164,Influenza A;hsa:3125,path:hsa05168,Herpes simplex virus 1 infection;hsa:3125,path:hsa05169,Epstein-Barr virus infection;hsa:3125,path:hsa05145,Toxoplasmosis;hsa:3125,path:hsa05140,Leishmaniasis;hsa:3126,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3126,path:hsa04145,Phagosome;hsa:3126,path:hsa04640,Hematopoietic cell lineage;hsa:3126,path:hsa04612,Antigen processing and presentation;hsa:3126,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3126,path:hsa04659,Th17 cell differentiation;hsa:3126,path:hsa04672,Intestinal immune network for IgA production;hsa:3126,path:hsa05310,Asthma;hsa:3126,path:hsa05322,Systemic lupus erythematosus;hsa:3126,path:hsa05323,Rheumatoid arthritis;hsa:3126,path:hsa05320,Autoimmune thyroid disease;hsa:3126,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3126,path:hsa05330,Allograft rejection;hsa:3126,path:hsa05332,Graft-versus-host disease;hsa:3126,path:hsa05416,Viral myocarditis;hsa:3126,path:hsa04940,Type I diabetes mellitus;hsa:3126,path:hsa05150,Staphylococcus aureus infection;hsa:3126,path:hsa05152,Tuberculosis;hsa:3126,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3126,path:hsa05164,Influenza A;hsa:3126,path:hsa05168,Herpes simplex virus 1 infection;hsa:3126,path:hsa05169,Epstein-Barr virus infection;hsa:3126,path:hsa05145,Toxoplasmosis;hsa:3126,path:hsa05140,Leishmaniasis;hsa:3107,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3107,path:hsa04144,Endocytosis;hsa:3107,path:hsa04145,Phagosome;hsa:3107,path:hsa04218,Cellular senescence;hsa:3107,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3107,path:hsa04612,Antigen processing and presentation;hsa:3107,path:hsa05203,Viral carcinogenesis;hsa:3107,path:hsa05320,Autoimmune thyroid disease;hsa:3107,path:hsa05330,Allograft rejection;hsa:3107,path:hsa05332,Graft-versus-host disease;hsa:3107,path:hsa05416,Viral myocarditis;hsa:3107,path:hsa04940,Type I diabetes mellitus;hsa:3107,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3107,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3107,path:hsa05168,Herpes simplex virus 1 infection;hsa:3107,path:hsa05163,Human cytomegalovirus infection;hsa:3107,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3107,path:hsa05169,Epstein-Barr virus infection;hsa:3107,path:hsa05165,Human papillomavirus infection;hsa:3135,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3135,path:hsa04144,Endocytosis;hsa:3135,path:hsa04145,Phagosome;hsa:3135,path:hsa04218,Cellular senescence;hsa:3135,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3135,path:hsa04612,Antigen processing and presentation;hsa:3135,path:hsa05203,Viral carcinogenesis;hsa:3135,path:hsa05320,Autoimmune thyroid disease;hsa:3135,path:hsa05330,Allograft rejection;hsa:3135,path:hsa05332,Graft-versus-host disease;hsa:3135,path:hsa05416,Viral myocarditis;hsa:3135,path:hsa04940,Type I diabetes mellitus;hsa:3135,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3135,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3135,path:hsa05168,Herpes simplex virus 1 infection;hsa:3135,path:hsa05163,Human cytomegalovirus infection;hsa:3135,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3135,path:hsa05169,Epstein-Barr virus infection;hsa:3135,path:hsa05165,Human papillomavirus infection;hsa:3127,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3127,path:hsa04145,Phagosome;hsa:3127,path:hsa04640,Hematopoietic cell lineage;hsa:3127,path:hsa04612,Antigen processing and presentation;hsa:3127,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3127,path:hsa04659,Th17 cell differentiation;hsa:3127,path:hsa04672,Intestinal immune network for IgA production;hsa:3127,path:hsa05310,Asthma;hsa:3127,path:hsa05322,Systemic lupus erythematosus;hsa:3127,path:hsa05323,Rheumatoid arthritis;hsa:3127,path:hsa05320,Autoimmune thyroid disease;hsa:3127,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3127,path:hsa05330,Allograft rejection;hsa:3127,path:hsa05332,Graft-versus-host disease;hsa:3127,path:hsa05416,Viral myocarditis;hsa:3127,path:hsa04940,Type I diabetes mellitus;hsa:3127,path:hsa05150,Staphylococcus aureus infection;hsa:3127,path:hsa05152,Tuberculosis;hsa:3127,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3127,path:hsa05164,Influenza A;hsa:3127,path:hsa05168,Herpes simplex virus 1 infection;hsa:3127,path:hsa05169,Epstein-Barr virus infection;hsa:3127,path:hsa05145,Toxoplasmosis;hsa:3127,path:hsa05140,Leishmaniasis;hsa:3118,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3118,path:hsa04145,Phagosome;hsa:3118,path:hsa04640,Hematopoietic cell lineage;hsa:3118,path:hsa04612,Antigen processing and presentation;hsa:3118,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3118,path:hsa04659,Th17 cell differentiation;hsa:3118,path:hsa04672,Intestinal immune network for IgA production;hsa:3118,path:hsa05310,Asthma;hsa:3118,path:hsa05322,Systemic lupus erythematosus;hsa:3118,path:hsa05323,Rheumatoid arthritis;hsa:3118,path:hsa05320,Autoimmune thyroid disease;hsa:3118,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3118,path:hsa05330,Allograft rejection;hsa:3118,path:hsa05332,Graft-versus-host disease;hsa:3118,path:hsa05416,Viral myocarditis;hsa:3118,path:hsa04940,Type I diabetes mellitus;hsa:3118,path:hsa05150,Staphylococcus aureus infection;hsa:3118,path:hsa05152,Tuberculosis;hsa:3118,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3118,path:hsa05164,Influenza A;hsa:3118,path:hsa05168,Herpes simplex virus 1 infection;hsa:3118,path:hsa05169,Epstein-Barr virus infection;hsa:3118,path:hsa05145,Toxoplasmosis;hsa:3118,path:hsa05140,Leishmaniasis;hsa:3117,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3117,path:hsa04145,Phagosome;hsa:3117,path:hsa04640,Hematopoietic cell lineage;hsa:3117,path:hsa04612,Antigen processing and presentation;hsa:3117,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3117,path:hsa04659,Th17 cell differentiation;hsa:3117,path:hsa04672,Intestinal immune network for IgA production;hsa:3117,path:hsa05310,Asthma;hsa:3117,path:hsa05322,Systemic lupus erythematosus;hsa:3117,path:hsa05323,Rheumatoid arthritis;hsa:3117,path:hsa05320,Autoimmune thyroid disease;hsa:3117,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3117,path:hsa05330,Allograft rejection;hsa:3117,path:hsa05332,Graft-versus-host disease;hsa:3117,path:hsa05416,Viral myocarditis;hsa:3117,path:hsa04940,Type I diabetes mellitus;hsa:3117,path:hsa05150,Staphylococcus aureus infection;hsa:3117,path:hsa05152,Tuberculosis;hsa:3117,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3117,path:hsa05164,Influenza A;hsa:3117,path:hsa05168,Herpes simplex virus 1 infection;hsa:3117,path:hsa05169,Epstein-Barr virus infection;hsa:3117,path:hsa05145,Toxoplasmosis;hsa:3117,path:hsa05140,Leishmaniasis
OTUB1_HUMAN	Q96FW1	OTUB1	Ubiquitin thioesterase OTUB1	2.154301717	2.66706403	2.85535181	1.569155908	2.4106828735	2.212253859	2.4106828735	2.212253859	1.08969540891193	0.405069	0	0.917687632545418	0.404812	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005737,cytoplasm	GO:0019784,NEDD8-specific protease activity;GO:0004843,thiol-dependent deubiquitinase;GO:0043130,ubiquitin binding;GO:0031625,ubiquitin protein ligase binding	GO:0002250,adaptive immune response;GO:0006974,cellular response to DNA damage stimulus;GO:0006281,DNA repair;GO:2000780,negative regulation of double-strand break repair;GO:1901315,negative regulation of histone H2A K63-linked ubiquitination;GO:0016579,protein deubiquitination;GO:0071108,protein K48-linked deubiquitination;GO:0071347,cellular response to interleukin-1	
AIMP2_HUMAN	Q13155	AIMP2	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	0.534562686	0.556180639	1.048781408	0.470774952	0.5453716625	0.75977818	0.5453716625	0.75977818	0.717803797024021	0.419816	0	1.39313835360854	0.419996	0	GO:0017101,aminoacyl-tRNA synthetase multienzyme complex;GO:0005829,cytosol;GO:0016020,membrane;GO:0005634,nucleus;GO:0005737,cytoplasm	GO:0060090,molecular adaptor activity	GO:0006915,apoptotic process;GO:0008285,negative regulation of cell population proliferation;GO:1903632,positive regulation of aminoacyl-tRNA ligase activity;GO:1901216,positive regulation of neuron death;GO:0031398,positive regulation of protein ubiquitination;GO:0065003,protein-containing complex assembly;GO:0006418,tRNA aminoacylation for protein translation;GO:0060510,type II pneumocyte differentiation	
H4_HUMAN	P62805	H4C1	Histone H4	57.64582988	289.4135442	54.11827923	111.6266006	173.52968704	82.872439915	173.52968704	82.872439915	2.09393722711657	0.214541	0	0.477569235147051	0.213990	0	GO:0000781,chromosome, telomeric region;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0016020,membrane;GO:0000228,nuclear chromosome;GO:0005654,nucleoplasm;GO:0000786,nucleosome;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0003677,DNA binding;GO:0019904,protein domain specific binding;GO:0046982,protein heterodimerization activity;GO:0003723,RNA binding	GO:1990000,amyloid fibril formation;GO:0034080,CENP-A containing nucleosome assembly;GO:0045007,depurination;GO:0006335,DNA replication-dependent nucleosome assembly;GO:0006336,DNA replication-independent nucleosome assembly;GO:0006352,DNA-templated transcription, initiation;GO:0006302,double-strand break repair;GO:0006303,double-strand break repair via nonhomologous end joining;GO:0007076,mitotic chromosome condensation;GO:0048239,negative regulation of DNA recombination at telomere;GO:0045814,negative regulation of gene expression, epigenetic;GO:0045653,negative regulation of megakaryocyte differentiation;GO:0006334,nucleosome assembly;GO:1900051,positive regulation of histone exchange;GO:0000183,rDNA heterochromatin assembly;GO:0060765,regulation of androgen receptor signaling pathway;GO:0060964,regulation of gene silencing by miRNA;GO:0045652,regulation of megakaryocyte differentiation;GO:0016233,telomere capping;GO:0032200,telomere organization;GO:0019058,viral life cycle	hsa:121504,path:hsa05203,Viral carcinogenesis;hsa:121504,path:hsa05322,Systemic lupus erythematosus;hsa:121504,path:hsa05034,Alcoholism;hsa:554313,path:hsa05203,Viral carcinogenesis;hsa:554313,path:hsa05322,Systemic lupus erythematosus;hsa:554313,path:hsa05034,Alcoholism;hsa:8294,path:hsa05203,Viral carcinogenesis;hsa:8294,path:hsa05322,Systemic lupus erythematosus;hsa:8294,path:hsa05034,Alcoholism;hsa:8359,path:hsa05203,Viral carcinogenesis;hsa:8359,path:hsa05322,Systemic lupus erythematosus;hsa:8359,path:hsa05034,Alcoholism;hsa:8360,path:hsa05203,Viral carcinogenesis;hsa:8360,path:hsa05322,Systemic lupus erythematosus;hsa:8360,path:hsa05034,Alcoholism;hsa:8361,path:hsa05203,Viral carcinogenesis;hsa:8361,path:hsa05322,Systemic lupus erythematosus;hsa:8361,path:hsa05034,Alcoholism;hsa:8362,path:hsa05203,Viral carcinogenesis;hsa:8362,path:hsa05322,Systemic lupus erythematosus;hsa:8362,path:hsa05034,Alcoholism;hsa:8363,path:hsa05203,Viral carcinogenesis;hsa:8363,path:hsa05322,Systemic lupus erythematosus;hsa:8363,path:hsa05034,Alcoholism;hsa:8364,path:hsa05203,Viral carcinogenesis;hsa:8364,path:hsa05322,Systemic lupus erythematosus;hsa:8364,path:hsa05034,Alcoholism;hsa:8365,path:hsa05203,Viral carcinogenesis;hsa:8365,path:hsa05322,Systemic lupus erythematosus;hsa:8365,path:hsa05034,Alcoholism;hsa:8366,path:hsa05203,Viral carcinogenesis;hsa:8366,path:hsa05322,Systemic lupus erythematosus;hsa:8366,path:hsa05034,Alcoholism;hsa:8367,path:hsa05203,Viral carcinogenesis;hsa:8367,path:hsa05322,Systemic lupus erythematosus;hsa:8367,path:hsa05034,Alcoholism;hsa:8368,path:hsa05203,Viral carcinogenesis;hsa:8368,path:hsa05322,Systemic lupus erythematosus;hsa:8368,path:hsa05034,Alcoholism;hsa:8370,path:hsa05203,Viral carcinogenesis;hsa:8370,path:hsa05322,Systemic lupus erythematosus;hsa:8370,path:hsa05034,Alcoholism
RHBD2_HUMAN	Q6NTF9	RHBDD2	Rhomboid domain-containing protein 2	2.55E-05	2.55E-05	2.55E-05	2.55E-05	2.55e-005	2.55e-005	2.55e-005	2.55e-005	1	0.433351	0	1	0.433154	0	GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0000839,Hrd1p ubiquitin ligase ERAD-L complex;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm	GO:0051787,misfolded protein binding;GO:0004252,serine-type endopeptidase activity;GO:1990381,ubiquitin-specific protease binding	GO:0030968,endoplasmic reticulum unfolded protein response;GO:0030433,ubiquitin-dependent ERAD pathway	
NOMO1_HUMAN	Q15155	NOMO1	Nodal modulator 1	0.03546293	0.00699279	2.55E-05	0.018379368	0.02122786	0.009202434	0.02122786	0.009202434	2.30676579696198	0.191508	0	0.433507381337544	0.190943	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0030246,carbohydrate binding;GO:0043022,ribosome binding		
RFA1_HUMAN	P27694	RPA1	Replication protein A 70 kDa DNA-binding subunit	0.942443015	0.583043104	1.577153886	1.371725839	0.7627430595	1.4744398625	0.7627430595	1.4744398625	0.517310389456457	0.241048	0	1.93307542315303	0.241371	0	GO:0000781,chromosome, telomeric region;GO:0005662,DNA replication factor A complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016605,PML body;GO:0090734,site of DNA damage	GO:0003684,damaged DNA binding;GO:0098505,G-rich strand telomeric DNA binding;GO:0046872,metal ion binding;GO:0003697,single-stranded DNA binding;GO:0043047,single-stranded telomeric DNA binding;GO:0003677,DNA binding	GO:0006284,base-excision repair;GO:0006287,base-excision repair, gap-filling;GO:0006974,cellular response to DNA damage stimulus;GO:0042769,DNA damage response, detection of DNA damage;GO:0006310,DNA recombination;GO:0006281,DNA repair;GO:0006260,DNA replication;GO:0006270,DNA replication initiation;GO:0006268,DNA unwinding involved in DNA replication;GO:0006261,DNA-dependent DNA replication;GO:0000724,double-strand break repair via homologous recombination;GO:0070987,error-free translesion synthesis;GO:0042276,error-prone translesion synthesis;GO:0036297,interstrand cross-link repair;GO:0051321,meiotic cell cycle;GO:0006298,mismatch repair;GO:0006289,nucleotide-excision repair;GO:0006297,nucleotide-excision repair, DNA gap filling;GO:0033683,nucleotide-excision repair, DNA incision;GO:0006295,nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006294,nucleotide-excision repair, preincision complex assembly;GO:0006293,nucleotide-excision repair, preincision complex stabilization;GO:0034502,protein localization to chromosome;GO:1900034,regulation of cellular response to heat;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0000723,telomere maintenance;GO:0032201,telomere maintenance via semi-conservative replication;GO:0007004,telomere maintenance via telomerase;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0019985,translesion synthesis	hsa:6117,path:hsa03030,DNA replication;hsa:6117,path:hsa03420,Nucleotide excision repair;hsa:6117,path:hsa03430,Mismatch repair;hsa:6117,path:hsa03440,Homologous recombination;hsa:6117,path:hsa03460,Fanconi anemia pathway
RCC2_HUMAN	Q9P258	RCC2	Protein RCC2	3.098574918	0.878887604	1.770603522	2.075714321	1.988731261	1.9231589215	1.988731261	1.9231589215	1.03409616270758	0.422263	0	0.9670280541238	0.422042	0	GO:0034506,chromosome, centromeric core domain;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0005874,microtubule;GO:0030496,midbody;GO:1990023,mitotic spindle midzone;GO:0005730,nucleolus;GO:0005886,plasma membrane	GO:0005085,guanyl-nucleotide exchange factor activity;GO:0008017,microtubule binding;GO:0019904,protein domain specific binding;GO:0019901,protein kinase binding;GO:0003723,RNA binding;GO:0031267,small GTPase binding	GO:0090630,activation of GTPase activity;GO:0051301,cell division;GO:0072356,chromosome passenger complex localization to kinetochore;GO:0045184,establishment of protein localization;GO:0048041,focal adhesion assembly;GO:0007229,integrin-mediated signaling pathway;GO:0007052,mitotic spindle organization;GO:0051895,negative regulation of focal adhesion assembly;GO:0034260,negative regulation of GTPase activity;GO:1900025,negative regulation of substrate adhesion-dependent cell spreading;GO:0051987,positive regulation of attachment of spindle microtubules to kinetochore;GO:0010971,positive regulation of G2/M transition of mitotic cell cycle;GO:0030334,regulation of cell migration;GO:0010762,regulation of fibroblast migration;GO:1900027,regulation of ruffle assembly	
CLP1L_HUMAN	Q96KA5	CLPTM1L	Cleft lip and palate transmembrane protein 1-like protein	0.382055603	0.087919634	0.705716229	0.173821202	0.2349876185	0.4397687155	0.2349876185	0.4397687155	0.534343645233673	0.256740	0	1.87145483794926	0.257056	0	GO:0012505,endomembrane system;GO:0016021,integral component of membrane;GO:0016020,membrane		GO:0006915,apoptotic process	
HEM2_HUMAN	P13716	ALAD	Delta-aminolevulinic acid dehydratase	0.914931343	2.929831925	2.039583953	11.02455024	1.922381634	6.5320670965	1.922381634	6.5320670965	0.294299125468268	0.058801	0	3.39790340324277	0.059039	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005634,nucleus;GO:0034774,secretory granule lumen	GO:0003824,catalytic activity;GO:0042802,identical protein binding;GO:0004655,porphobilinogen synthase activity;GO:1904854,proteasome core complex binding;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0071353,cellular response to interleukin-4;GO:0071284,cellular response to lead ion;GO:0006783,heme biosynthetic process;GO:1901799,negative regulation of proteasomal protein catabolic process;GO:0043312,neutrophil degranulation;GO:0051260,protein homooligomerization;GO:0006782,protoporphyrinogen IX biosynthetic process;GO:0014823,response to activity;GO:0010044,response to aluminum ion;GO:0043200,response to amino acid;GO:0046685,response to arsenic-containing substance;GO:0046686,response to cadmium ion;GO:0032025,response to cobalt ion;GO:0042493,response to drug;GO:0045471,response to ethanol;GO:0070542,response to fatty acid;GO:0051384,response to glucocorticoid;GO:0009635,response to herbicide;GO:0001666,response to hypoxia;GO:0010212,response to ionizing radiation;GO:0010039,response to iron ion;GO:0032496,response to lipopolysaccharide;GO:0046689,response to mercury ion;GO:0051597,response to methylmercury;GO:0006979,response to oxidative stress;GO:0070541,response to platinum ion;GO:0010269,response to selenium ion;GO:0010266,response to vitamin B1;GO:0033197,response to vitamin E;GO:0010043,response to zinc ion	hsa:210,path:hsa00860,Porphyrin and chlorophyll metabolism
NNMT_HUMAN	P40261	NNMT	Nicotinamide N-methyltransferase	7.786663001	9.259929867	4.599248194	2.805605748	8.523296434	3.702426971	8.523296434	3.702426971	2.30208360644529	0.191975	0	0.434389088736932	0.191411	0	GO:0005829,cytosol	GO:0008170,N-methyltransferase activity;GO:0008112,nicotinamide N-methyltransferase activity	GO:0031100,animal organ regeneration;GO:0032259,methylation;GO:0034356,NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0042493,response to drug;GO:0010243,response to organonitrogen compound	hsa:4837,path:hsa00760,Nicotinate and nicotinamide metabolism
ARGI1_HUMAN	P05089	ARG1	Arginase-1	0.602376289	0.88309824	0.637071251	0.230474562	0.7427372645	0.4337729065	0.7427372645	0.4337729065	1.71227214371905	0.267248	0	0.584019312390378	0.266750	0	GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005741,mitochondrial outer membrane;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0005634,nucleus;GO:0035580,specific granule lumen	GO:0004053,arginase activity;GO:0042802,identical protein binding;GO:0030145,manganese ion binding;GO:0016813,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines;GO:0046872,metal ion binding	GO:0002250,adaptive immune response;GO:0007568,aging;GO:0006527,arginine catabolic process;GO:0019547,arginine catabolic process to ornithine;GO:0071549,cellular response to dexamethasone stimulus;GO:0071377,cellular response to glucagon stimulus;GO:0070301,cellular response to hydrogen peroxide;GO:0071353,cellular response to interleukin-4;GO:0071222,cellular response to lipopolysaccharide;GO:0071560,cellular response to transforming growth factor beta stimulus;GO:0032964,collagen biosynthetic process;GO:0042832,defense response to protozoan;GO:0045087,innate immune response;GO:0001889,liver development;GO:0030324,lung development;GO:0060056,mammary gland involution;GO:0060135,maternal process involved in female pregnancy;GO:0046007,negative regulation of activated T cell proliferation;GO:0060336,negative regulation of interferon-gamma-mediated signaling pathway;GO:0042130,negative regulation of T cell proliferation;GO:2000552,negative regulation of T-helper 2 cell cytokine production;GO:0043312,neutrophil degranulation;GO:0001938,positive regulation of endothelial cell proliferation;GO:0070965,positive regulation of neutrophil mediated killing of fungus;GO:0010963,regulation of L-arginine import;GO:0014075,response to amine;GO:0043200,response to amino acid;GO:0048678,response to axon injury;GO:0046686,response to cadmium ion;GO:0042493,response to drug;GO:0009635,response to herbicide;GO:0010042,response to manganese ion;GO:0051597,response to methylmercury;GO:0010269,response to selenium ion;GO:0033189,response to vitamin A;GO:0033197,response to vitamin E;GO:0010043,response to zinc ion;GO:0000050,urea cycle;GO:0006525,arginine metabolic process	hsa:383,path:hsa00220,Arginine biosynthesis;hsa:383,path:hsa00330,Arginine and proline metabolism;hsa:383,path:hsa05146,Amoebiasis
RENBP_HUMAN	P51606	RENBP	N-acylglucosamine 2-epimerase	0.655543718	1.191580131	0.899836609	1.304937593	0.9235619245	1.102387101	0.9235619245	1.102387101	0.837783682031671	0.492554	0	1.19362554015727	0.492487	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0005524,ATP binding;GO:0004866,endopeptidase inhibitor activity;GO:0004857,enzyme inhibitor activity;GO:0042802,identical protein binding;GO:0050121,N-acylglucosamine 2-epimerase activity;GO:0030414,peptidase inhibitor activity	GO:0005975,carbohydrate metabolic process;GO:0006044,N-acetylglucosamine metabolic process;GO:0006051,N-acetylmannosamine metabolic process;GO:0019262,N-acetylneuraminate catabolic process;GO:0008217,regulation of blood pressure;GO:0006048,UDP-N-acetylglucosamine biosynthetic process	hsa:5973,path:hsa00520,Amino sugar and nucleotide sugar metabolism
SF01_HUMAN	Q15637	SF1	Splicing factor 1	0.557131961	0.265502461	0.604579126	0.437268321	0.411317211	0.5209237235	0.411317211	0.5209237235	0.789592012121137	0.477395	0	1.26647684455879	0.477511	0	GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005840,ribosome;GO:0005681,spliceosomal complex	GO:0042802,identical protein binding;GO:0003729,mRNA binding;GO:0045131,pre-mRNA branch point binding;GO:0003723,RNA binding;GO:0003714,transcription corepressor activity;GO:0008270,zinc ion binding	GO:0000389,mRNA 3'-splice site recognition;GO:0000398,mRNA splicing, via spliceosome;GO:0048024,regulation of mRNA splicing, via spliceosome;GO:0000245,spliceosomal complex assembly	
CYBP_HUMAN	Q9HB71	CACYBP	Calcyclin-binding protein	1.771760938	1.162181671	1.162738619	0.063619013	1.4669713045	0.613178816	1.4669713045	0.613178816	2.3924037592649	0.183243	0	0.417989645822687	0.182675	0	GO:0030877,beta-catenin destruction complex;GO:0044297,cell body;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0043005,neuron projection;GO:0005641,nuclear envelope lumen;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0019005,SCF ubiquitin ligase complex	GO:0019904,protein domain specific binding;GO:0042803,protein homodimerization activity;GO:0044548,S100 protein binding;GO:0015631,tubulin binding;GO:0031625,ubiquitin protein ligase binding	GO:0007568,aging;GO:0055007,cardiac muscle cell differentiation;GO:0071277,cellular response to calcium ion;GO:1990830,cellular response to leukemia inhibitory factor;GO:0007507,heart development;GO:0060548,negative regulation of cell death;GO:0045740,positive regulation of DNA replication;GO:0060416,response to growth hormone	hsa:27101,path:hsa04310,Wnt signaling pathway
PROF1_HUMAN	P07737	PFN1	Profilin-1	48.01639766	74.4619409	42.81040608	31.69334242	61.23916928	37.25187425	61.23916928	37.25187425	1.64392182978552	0.278661	0	0.608301430081058	0.278179	0	GO:0072562,blood microparticle;GO:0005938,cell cortex;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005634,nucleus	GO:0003779,actin binding;GO:0003785,actin monomer binding;GO:0000774,adenyl-nucleotide exchange factor activity;GO:0045296,cadherin binding;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding;GO:0001784,phosphotyrosine residue binding;GO:0070064,proline-rich region binding;GO:0003723,RNA binding	GO:0030036,actin cytoskeleton organization;GO:0032232,negative regulation of actin filament bundle assembly;GO:0030837,negative regulation of actin filament polymerization;GO:0051497,negative regulation of stress fiber assembly;GO:0032233,positive regulation of actin filament bundle assembly;GO:0030838,positive regulation of actin filament polymerization;GO:0032781,positive regulation of ATPase activity;GO:0010634,positive regulation of epithelial cell migration;GO:1900029,positive regulation of ruffle assembly;GO:0050821,protein stabilization;GO:0030833,regulation of actin filament polymerization;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5216,path:hsa04015,Rap1 signaling pathway;hsa:5216,path:hsa04810,Regulation of actin cytoskeleton;hsa:5216,path:hsa05132,Salmonella infection;hsa:5216,path:hsa05131,Shigellosis
WDFY1_HUMAN	Q8IWB7	WDFY1	WD repeat and FYVE domain-containing protein 1	0.433502249	0.352709912	0.227442216	0.473394942	0.3931060805	0.350418579	0.3931060805	0.350418579	1.12181860226081	0.395606	0	0.891409714533785	0.395330	0	GO:0005829,cytosol;GO:0005769,early endosome;GO:0005634,nucleus	GO:0005545,1-phosphatidylinositol binding;GO:0008270,zinc ion binding	GO:0034141,positive regulation of toll-like receptor 3 signaling pathway;GO:0034145,positive regulation of toll-like receptor 4 signaling pathway	
IF2A_HUMAN	P05198	EIF2S1	Eukaryotic translation initiation factor 2 subunit 1	3.766954675	2.312166218	4.647545864	2.89043831	3.0395604465	3.768992087	3.0395604465	3.768992087	0.806465064488738	0.490274	0	1.2399793171871	0.490376	0	GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0033290,eukaryotic 48S preinitiation complex;GO:0005850,eukaryotic translation initiation factor 2 complex;GO:0005851,eukaryotic translation initiation factor 2B complex;GO:0070062,extracellular exosome;GO:0097451,glial limiting end-foot;GO:0016020,membrane;GO:0043614,multi-eIF complex;GO:0005634,nucleus;GO:0005844,polysome;GO:0045202,synapse;GO:0044207,translation initiation ternary complex	GO:0043022,ribosome binding;GO:0003723,RNA binding;GO:0003743,translation initiation factor activity	GO:0007568,aging;GO:0034198,cellular response to amino acid starvation;GO:0034605,cellular response to heat;GO:0034599,cellular response to oxidative stress;GO:0034644,cellular response to UV;GO:1905098,negative regulation of guanyl-nucleotide exchange factor activity;GO:0032057,negative regulation of translational initiation in response to stress;GO:0036499,PERK-mediated unfolded protein response;GO:1901216,positive regulation of neuron death;GO:2000676,positive regulation of type B pancreatic cell apoptotic process;GO:0046777,protein autophosphorylation;GO:0034976,response to endoplasmic reticulum stress;GO:1990737,response to manganese-induced endoplasmic reticulum stress;GO:0034063,stress granule assembly;GO:0006413,translational initiation;GO:0055085,transmembrane transport	hsa:1965,path:hsa03013,RNA transport;hsa:1965,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:1965,path:hsa04140,Autophagy - animal;hsa:1965,path:hsa04210,Apoptosis;hsa:1965,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:1965,path:hsa05162,Measles;hsa:1965,path:hsa05164,Influenza A;hsa:1965,path:hsa05160,Hepatitis C;hsa:1965,path:hsa05168,Herpes simplex virus 1 infection
RAB21_HUMAN	Q9UL25	RAB21	Ras-related protein Rab-21	2.087397863	4.602666541	0.257123131	0.223522598	3.345032202	0.2403228645	3.345032202	0.2403228645	13.9189095010142	0.008486	1	0.0718447088061845	0.008361	-1	GO:1904115,axon cytoplasm;GO:0032154,cleavage furrow;GO:0098559,cytoplasmic side of early endosome membrane;GO:0009898,cytoplasmic side of plasma membrane;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0012505,endomembrane system;GO:0005789,endoplasmic reticulum membrane;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0032580,Golgi cisterna membrane;GO:0045202,synapse;GO:0005802,trans-Golgi network;GO:0012506,vesicle membrane	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0008089,anterograde axonal transport;GO:0006886,intracellular protein transport;GO:0050775,positive regulation of dendrite morphogenesis;GO:2000643,positive regulation of early endosome to late endosome transport;GO:0048260,positive regulation of receptor-mediated endocytosis;GO:0050821,protein stabilization;GO:0032482,Rab protein signal transduction;GO:0030516,regulation of axon extension;GO:0017157,regulation of exocytosis	
SEPT2_HUMAN	Q15019	SEPTIN2	Septin-2	10.12315786	8.793291519	10.93399529	20.66453981	9.4582246895	15.79926755	9.4582246895	15.79926755	0.59864956774531	0.315697	0	1.67042632932367	0.315974	0	GO:0015629,actin cytoskeleton;GO:0005930,axoneme;GO:0032153,cell division site;GO:0060170,ciliary membrane;GO:0032154,cleavage furrow;GO:0000777,condensed chromosome kinetochore;GO:0005737,cytoplasm;GO:0000145,exocyst;GO:0070062,extracellular exosome;GO:0045171,intercellular bridge;GO:0015630,microtubule cytoskeleton;GO:0030496,midbody;GO:0097730,non-motile cilium;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0032391,photoreceptor connecting cilium;GO:0005886,plasma membrane;GO:0031105,septin complex;GO:0005940,septin ring;GO:0097227,sperm annulus;GO:0005819,spindle;GO:0008021,synaptic vesicle;GO:0031514,motile cilium	GO:0045296,cadherin binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0060090,molecular adaptor activity	GO:0034613,cellular protein localization;GO:0060271,cilium assembly;GO:0061640,cytoskeleton-dependent cytokinesis;GO:0031175,neuron projection development;GO:0017157,regulation of exocytosis;GO:0007224,smoothened signaling pathway;GO:0007283,spermatogenesis;GO:0051301,cell division	hsa:4735,path:hsa05131,Shigellosis;hsa:4735,path:hsa05100,Bacterial invasion of epithelial cells
CO4A3_HUMAN	Q01955	COL4A3	Collagen alpha-3(IV) chain	1.671161681	2.150096506	1.974659989	16.45981126	1.9106290935	9.2172356245	1.9106290935	9.2172356245	0.207288732906147	0.017841	-1	4.82418887886572	0.017957	1	GO:0005604,basement membrane;GO:0005587,collagen type IV trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043231,intracellular membrane-bounded organelle;GO:0005581,collagen trimer;GO:0016020,membrane	GO:0005201,extracellular matrix structural constituent;GO:0030020,extracellular matrix structural constituent conferring tensile strength;GO:0005178,integrin binding;GO:0008191,metalloendopeptidase inhibitor activity;GO:0005198,structural molecule activity	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0008015,blood circulation;GO:0007155,cell adhesion;GO:0007166,cell surface receptor signaling pathway;GO:0030199,collagen fibril organization;GO:0038063,collagen-activated tyrosine kinase receptor signaling pathway;GO:0072577,endothelial cell apoptotic process;GO:0030198,extracellular matrix organization;GO:0032836,glomerular basement membrane development;GO:0016525,negative regulation of angiogenesis;GO:0008285,negative regulation of cell population proliferation;GO:1905563,negative regulation of vascular endothelial cell proliferation;GO:0009749,response to glucose;GO:0007605,sensory perception of sound	hsa:1285,path:hsa04151,PI3K-Akt signaling pathway;hsa:1285,path:hsa04512,ECM-receptor interaction;hsa:1285,path:hsa04510,Focal adhesion;hsa:1285,path:hsa04926,Relaxin signaling pathway;hsa:1285,path:hsa04974,Protein digestion and absorption;hsa:1285,path:hsa05200,Pathways in cancer;hsa:1285,path:hsa05222,Small cell lung cancer;hsa:1285,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:1285,path:hsa05165,Human papillomavirus infection;hsa:1285,path:hsa05146,Amoebiasis
PDIA3_HUMAN	P30101	PDIA3	Protein disulfide-isomerase A3	61.15981785	74.02974729	90.78673808	74.19238746	67.59478257	82.48956277	67.59478257	82.48956277	0.819434365999368	0.500000	0	1.22035399233033	0.499950	0	GO:0009986,cell surface;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0042470,melanosome;GO:0042824,MHC class I peptide loading complex;GO:0005634,nucleus;GO:0045335,phagocytic vesicle;GO:0055038,recycling endosome membrane	GO:0004197,cysteine-type endopeptidase activity;GO:0015036,disulfide oxidoreductase activity;GO:0042802,identical protein binding;GO:0015037,peptide disulfide oxidoreductase activity;GO:0004629,phospholipase C activity;GO:0003756,protein disulfide isomerase activity;GO:0003723,RNA binding	GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0098761,cellular response to interleukin-7;GO:2001238,positive regulation of extrinsic apoptotic signaling pathway;GO:0006457,protein folding;GO:0034975,protein folding in endoplasmic reticulum;GO:0034976,response to endoplasmic reticulum stress	hsa:2923,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:2923,path:hsa04612,Antigen processing and presentation;hsa:2923,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:2923,path:hsa05168,Herpes simplex virus 1 infection;hsa:2923,path:hsa05163,Human cytomegalovirus infection;hsa:2923,path:hsa05169,Epstein-Barr virus infection
BAF_HUMAN	O75531	BANF1	Barrier-to-autointegration factor	0.262068185	0.29745118	0.133046454	0.21224694	0.2797596825	0.172646697	0.2797596825	0.172646697	1.62041722987611	0.282752	0	0.617125010498966	0.282276	0	GO:0000793,condensed chromosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005635,nuclear envelope;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0019899,enzyme binding;GO:0042802,identical protein binding;GO:0097726,LEM domain binding;GO:0008022,protein C-terminus binding;GO:0042803,protein homodimerization activity;GO:0047485,protein N-terminus binding	GO:0030261,chromosome condensation;GO:0007059,chromosome segregation;GO:0015074,DNA integration;GO:0075713,establishment of integrated proviral latency;GO:0007084,mitotic nuclear envelope reassembly;GO:0045071,negative regulation of viral genome replication;GO:0051169,nuclear transport;GO:0009615,response to virus	
WDR26_HUMAN	Q9H7D7	WDR26	WD repeat-containing protein 26	0.11524365	0.055654161	0.107404345	2.55E-05	0.0854489055	0.0537149225	0.0854489055	0.0537149225	1.59078523291177	0.288037	0	0.628620368929126	0.287568	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000151,ubiquitin ligase complex			
RAB13_HUMAN	P51153	RAB13	Ras-related protein Rab-13	3.253339645	6.228692093	1.089388317	0.622659706	4.741015869	0.8560240115	4.741015869	0.8560240115	5.53841458336242	0.053635	0	0.180557086319257	0.053230	0	GO:0005923,bicellular tight junction;GO:0030054,cell junction;GO:0031410,cytoplasmic vesicle;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0030139,endocytic vesicle;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0032593,insulin-responsive compartment;GO:0030027,lamellipodium;GO:0016328,lateral plasma membrane;GO:0043005,neuron projection;GO:0005886,plasma membrane;GO:0055037,recycling endosome;GO:0055038,recycling endosome membrane;GO:0008021,synaptic vesicle;GO:0005802,trans-Golgi network;GO:0030140,trans-Golgi network transport vesicle	GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0070830,bicellular tight junction assembly;GO:0032869,cellular response to insulin stimulus;GO:0030866,cortical actin cytoskeleton organization;GO:0032456,endocytic recycling;GO:0016197,endosomal transport;GO:0035767,endothelial cell chemotaxis;GO:0097368,establishment of Sertoli cell barrier;GO:0048210,Golgi vesicle fusion to target membrane;GO:0031175,neuron projection development;GO:0043687,post-translational protein modification;GO:0010737,protein kinase A signaling;GO:0072659,protein localization to plasma membrane;GO:0009306,protein secretion;GO:0017157,regulation of exocytosis;GO:0044795,trans-Golgi network to recycling endosome transport;GO:0006904,vesicle docking involved in exocytosis	hsa:5872,path:hsa04530,Tight junction
EIF3H_HUMAN	O15372	EIF3H	Eukaryotic translation initiation factor 3 subunit H	0.725651315	0.455093974	1.256150508	0.330097578	0.5903726445	0.793124043	0.5903726445	0.793124043	0.74436357050394	0.441630	0	1.34342952775482	0.441786	0	GO:0005829,cytosol;GO:0016282,eukaryotic 43S preinitiation complex;GO:0033290,eukaryotic 48S preinitiation complex;GO:0005852,eukaryotic translation initiation factor 3 complex;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0042788,polysomal ribosome;GO:0071541,eukaryotic translation initiation factor 3 complex, eIF3m	GO:0101005,deubiquitinase activity;GO:0070122,isopeptidase activity;GO:0008237,metallopeptidase activity;GO:0003723,RNA binding;GO:0003743,translation initiation factor activity	GO:0001732,formation of cytoplasmic translation initiation complex;GO:0032435,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0006446,regulation of translational initiation;GO:0006413,translational initiation	hsa:8667,path:hsa03013,RNA transport;hsa:8667,path:hsa05162,Measles
MBOA5_HUMAN	Q6P1A2	LPCAT3	Lysophospholipid acyltransferase 5	0.589603083	1.262929359	2.174834878	1.639144936	0.926266221	1.906989907	0.926266221	1.906989907	0.485721616879014	0.212080	0	2.05879245487459	0.212412	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0047184,1-acylglycerophosphocholine O-acyltransferase activity;GO:0106262,1-acylglycerophosphoethanolamine O-acyltransferase activity;GO:0106263,1-acylglycerophosphoserine O-acyltransferase activity;GO:0071617,lysophospholipid acyltransferase activity;GO:0016746,transferase activity, transferring acyl groups	GO:0034378,chylomicron assembly;GO:0090158,endoplasmic reticulum membrane organization;GO:0036335,intestinal stem cell homeostasis;GO:0030258,lipid modification;GO:0050728,negative regulation of inflammatory response;GO:1903573,negative regulation of response to endoplasmic reticulum stress;GO:0036151,phosphatidylcholine acyl-chain remodeling;GO:0006656,phosphatidylcholine biosynthetic process;GO:0036152,phosphatidylethanolamine acyl-chain remodeling;GO:0036150,phosphatidylserine acyl-chain remodeling;GO:0045797,positive regulation of intestinal cholesterol absorption;GO:1901310,positive regulation of sterol regulatory element binding protein cleavage;GO:1905885,positive regulation of triglyceride transport;GO:0045540,regulation of cholesterol biosynthetic process;GO:0034379,very-low-density lipoprotein particle assembly	hsa:10162,path:hsa00564,Glycerophospholipid metabolism;hsa:10162,path:hsa04216,Ferroptosis
HNRH3_HUMAN	P31942	HNRNPH3	Heterogeneous nuclear ribonucleoprotein H3	5.131888021	4.922817102	5.22637312	9.630949984	5.0273525615	7.428661552	5.0273525615	7.428661552	0.676750788322898	0.385004	0	1.47764881438582	0.385219	0	GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0005681,spliceosomal complex	GO:0003723,RNA binding	GO:0030855,epithelial cell differentiation;GO:0000398,mRNA splicing, via spliceosome;GO:0043484,regulation of RNA splicing;GO:0006396,RNA processing;GO:0008380,RNA splicing	
LMNB2_HUMAN	Q03252	LMNB2	Lamin-B2	14.48554617	12.29679806	15.59827397	31.99317475	13.391172115	23.79572436	13.391172115	23.79572436	0.562755388842468	0.282897	0	1.77697098921949	0.283197	0	GO:0005882,intermediate filament;GO:0005637,nuclear inner membrane;GO:0031965,nuclear membrane	GO:0042802,identical protein binding		hsa:84823,path:hsa04210,Apoptosis
GSHB_HUMAN	P48637	GSS	Glutathione synthetase	3.623006313	3.987451193	4.603679106	4.639821781	3.805228753	4.6217504435	3.805228753	4.6217504435	0.823330640526394	0.498405	0	1.21457887120617	0.498351	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0005524,ATP binding;GO:0043295,glutathione binding;GO:0004363,glutathione synthase activity;GO:0016594,glycine binding;GO:0042802,identical protein binding;GO:0000287,magnesium ion binding;GO:0042803,protein homodimerization activity;GO:0046872,metal ion binding	GO:0007568,aging;GO:0006520,cellular amino acid metabolic process;GO:0006750,glutathione biosynthetic process;GO:0007399,nervous system development;GO:0043200,response to amino acid;GO:0046686,response to cadmium ion;GO:0031667,response to nutrient levels;GO:0006979,response to oxidative stress;GO:0034612,response to tumor necrosis factor;GO:0009410,response to xenobiotic stimulus	hsa:2937,path:hsa00270,Cysteine and methionine metabolism;hsa:2937,path:hsa00480,Glutathione metabolism;hsa:2937,path:hsa04216,Ferroptosis
STRBP_HUMAN	Q96SI9	STRBP	Spermatid perinuclear RNA-binding protein	0.093305232	0.206103693	0.038090313	0.105657208	0.1497044625	0.0718737605	0.1497044625	0.0718737605	2.08288061538119	0.215846	0	0.480104328887324	0.215295	0	GO:0005737,cytoplasm;GO:0002177,manchette;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0003725,double-stranded RNA binding;GO:0008017,microtubule binding;GO:0003723,RNA binding;GO:0003727,single-stranded RNA binding	GO:0007638,mechanosensory behavior;GO:0007275,multicellular organism development;GO:0007286,spermatid development;GO:0007283,spermatogenesis	
MMP12_HUMAN	P39900	MMP12	Macrophage metalloelastase	0.014059481	2.55E-05	0.085923446	0.053608288	0.0070424905	0.069765867	0.0070424905	0.069765867	0.100944642456748	0.000687	-1	9.90641975306889	0.000696	1	GO:0005737,cytoplasm;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005634,nucleus	GO:0005509,calcium ion binding;GO:0005518,collagen binding;GO:0001046,core promoter sequence-specific DNA binding;GO:0004175,endopeptidase activity;GO:0004222,metalloendopeptidase activity;GO:0043565,sequence-specific DNA binding;GO:0008270,zinc ion binding	GO:0060435,bronchiole development;GO:0098586,cellular response to virus;GO:0030574,collagen catabolic process;GO:0060309,elastin catabolic process;GO:0022617,extracellular matrix disassembly;GO:0030198,extracellular matrix organization;GO:0048286,lung alveolus development;GO:1904905,negative regulation of endothelial cell-matrix adhesion via fibronectin;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0060339,negative regulation of type I interferon-mediated signaling pathway;GO:0060054,positive regulation of epithelial cell proliferation involved in wound healing;GO:0032727,positive regulation of interferon-alpha production;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0060340,positive regulation of type I interferon-mediated signaling pathway;GO:0006606,protein import into nucleus;GO:0006508,proteolysis;GO:0050691,regulation of defense response to virus by host;GO:1904645,response to amyloid-beta;GO:0035313,wound healing, spreading of epidermal cells	
MAP2_HUMAN	P50579	METAP2	Methionine aminopeptidase 2	0.325346327	0.443350695	0.5474694	0.183072755	0.384348511	0.3652710775	0.384348511	0.3652710775	1.05222815239184	0.416538	0	0.950364232060209	0.416305	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005886,plasma membrane	GO:0004177,aminopeptidase activity;GO:0046872,metal ion binding;GO:0070006,metalloaminopeptidase activity;GO:0008235,metalloexopeptidase activity;GO:0003723,RNA binding	GO:0031365,N-terminal protein amino acid modification;GO:0018206,peptidyl-methionine modification;GO:0070084,protein initiator methionine removal;GO:0016485,protein processing;GO:0022400,regulation of rhodopsin mediated signaling pathway	
ATLA3_HUMAN	Q6DD88	ATL3	Atlastin-3	1.931028489	1.859814838	2.613044094	2.886517639	1.8954216635	2.7497808665	1.8954216635	2.7497808665	0.689299168014267	0.395779	0	1.45074888582965	0.395984	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0071782,endoplasmic reticulum tubular network;GO:0098826,endoplasmic reticulum tubular network membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding	GO:0007029,endoplasmic reticulum organization;GO:0007030,Golgi organization;GO:1903373,positive regulation of endoplasmic reticulum tubular network organization;GO:0051260,protein homooligomerization	
ANCHR_HUMAN	Q96K21	ZFYVE19	Abscission/NoCut checkpoint regulator	0.045368982	0.023277058	2.55E-05	2.55E-05	0.03432302	2.55e-005	0.03432302	2.55e-005	1346.00078431373	0.000000	1	0.000742941617608241	0.000000	-1	GO:0005813,centrosome;GO:0032154,cleavage furrow;GO:0005737,cytoplasm;GO:0090543,Flemming body;GO:0030496,midbody	GO:0046872,metal ion binding;GO:0032266,phosphatidylinositol-3-phosphate binding	GO:0009838,abscission;GO:0051301,cell division;GO:0044878,mitotic cytokinesis checkpoint;GO:0032466,negative regulation of cytokinesis	
ASAH1_HUMAN	Q13510	ASAH1	Acid ceramidase	5.378768715	11.04728178	13.69009347	12.87512021	8.2130252475	13.28260684	8.2130252475	13.28260684	0.618329319419952	0.333476	0	1.61726117231201	0.333738	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0043202,lysosomal lumen;GO:0005764,lysosome;GO:0005634,nucleus;GO:1904724,tertiary granule lumen;GO:0016021,integral component of membrane	GO:0102121,ceramidase activity;GO:0017064,fatty acid amide hydrolase activity;GO:0016810,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0016811,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides;GO:0017040,N-acylsphingosine amidohydrolase activity;GO:0016922,nuclear receptor binding;GO:0003714,transcription corepressor activity;GO:0016787,hydrolase activity	GO:0071356,cellular response to tumor necrosis factor;GO:0046513,ceramide biosynthetic process;GO:0046514,ceramide catabolic process;GO:0006631,fatty acid metabolic process;GO:0006687,glycosphingolipid metabolic process;GO:0030216,keratinocyte differentiation;GO:1903507,negative regulation of nucleic acid-templated transcription;GO:0043312,neutrophil degranulation;GO:0062098,regulation of programmed necrotic cell death;GO:0050810,regulation of steroid biosynthetic process;GO:0046512,sphingosine biosynthetic process	hsa:427,path:hsa00600,Sphingolipid metabolism;hsa:427,path:hsa04071,Sphingolipid signaling pathway;hsa:427,path:hsa04142,Lysosome
RT23_HUMAN	Q9Y3D9	MRPS23	28S ribosomal protein S23, mitochondrial	1.305314457	2.302256725	0.065116931	0.013961247	1.803785591	0.039539089	1.803785591	0.039539089	45.6203123698677	0.000352	1	0.0219200603426929	0.000342	-1	GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0031965,nuclear membrane;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination;GO:0006412,translation	
STXB3_HUMAN	O00186	STXBP3	Syntaxin-binding protein 3	0.830509913	0.219175035	0.570771437	0.738206057	0.524842474	0.654488747	0.524842474	0.654488747	0.801912143494806	0.486824	0	1.24701939995809	0.486930	0	GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0045335,phagocytic vesicle;GO:0005886,plasma membrane;GO:0031091,platelet alpha granule;GO:0098793,presynapse;GO:0030141,secretory granule;GO:0042581,specific granule;GO:0070820,tertiary granule	GO:0044877,protein-containing complex binding;GO:0019905,syntaxin binding;GO:0017075,syntaxin-1 binding	GO:0007420,brain development;GO:0001678,cellular glucose homeostasis;GO:0071346,cellular response to interferon-gamma;GO:0030073,insulin secretion;GO:0006886,intracellular protein transport;GO:0045955,negative regulation of calcium ion-dependent exocytosis;GO:0046325,negative regulation of glucose import;GO:0007269,neurotransmitter secretion;GO:0043312,neutrophil degranulation;GO:0070527,platelet aggregation;GO:0022615,protein to membrane docking;GO:0032868,response to insulin;GO:0006904,vesicle docking involved in exocytosis;GO:0016192,vesicle-mediated transport	
MAP1S_HUMAN	Q66K74	MAP1S	Microtubule-associated protein 1S	0.572875456	2.467675446	0.685152478	0.673934814	1.520275451	0.679543646	1.520275451	0.679543646	2.23720059770819	0.198625	0	0.446987186139862	0.198063	0	GO:0030054,cell junction;GO:0042995,cell projection;GO:0005829,cytosol;GO:0030425,dendrite;GO:0005874,microtubule;GO:0005875,microtubule associated complex;GO:0043025,neuronal cell body;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005819,spindle;GO:0045202,synapse	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0048487,beta-tubulin binding;GO:0003677,DNA binding;GO:0008017,microtubule binding;GO:0015631,tubulin binding	GO:0006915,apoptotic process;GO:0006914,autophagy;GO:0007409,axonogenesis;GO:0007420,brain development;GO:0016358,dendrite development;GO:0006259,DNA metabolic process;GO:0001578,microtubule bundle formation;GO:0000226,microtubule cytoskeleton organization;GO:0047497,mitochondrion transport along microtubule;GO:0007399,nervous system development;GO:0048812,neuron projection morphogenesis;GO:0010848,regulation of chromatin disassembly;GO:0031114,regulation of microtubule depolymerization	
CPT1A_HUMAN	P50416	CPT1A	Carnitine O-palmitoyltransferase 1, liver isoform	0.708359998	0.779120963	1.051776098	1.270200756	0.7437404805	1.160988427	0.7437404805	1.160988427	0.6406097280589	0.353370	0	1.56101282293992	0.353615	0	GO:0031307,integral component of mitochondrial outer membrane;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0016021,integral component of membrane	GO:0004095,carnitine O-palmitoyltransferase activity;GO:0042802,identical protein binding;GO:1990698,palmitoleoyltransferase activity;GO:0016746,transferase activity, transferring acyl groups	GO:0009437,carnitine metabolic process;GO:0006853,carnitine shuttle;GO:0071398,cellular response to fatty acid;GO:0042755,eating behavior;GO:0030855,epithelial cell differentiation;GO:0006635,fatty acid beta-oxidation;GO:0006631,fatty acid metabolic process;GO:0006006,glucose metabolic process;GO:0097421,liver regeneration;GO:0001676,long-chain fatty acid metabolic process;GO:0032000,positive regulation of fatty acid beta-oxidation;GO:0050796,regulation of insulin secretion;GO:0010883,regulation of lipid storage;GO:0043279,response to alkaloid;GO:0046677,response to antibiotic;GO:0042493,response to drug;GO:0045471,response to ethanol;GO:0031667,response to nutrient levels;GO:0014070,response to organic cyclic compound;GO:1904772,response to tetrachloromethane;GO:0006641,triglyceride metabolic process	hsa:1374,path:hsa00071,Fatty acid degradation;hsa:1374,path:hsa04152,AMPK signaling pathway;hsa:1374,path:hsa04922,Glucagon signaling pathway;hsa:1374,path:hsa04920,Adipocytokine signaling pathway;hsa:1374,path:hsa03320,PPAR signaling pathway;hsa:1374,path:hsa04714,Thermogenesis;hsa:1374,path:hsa04931,Insulin resistance
EGLN1_HUMAN	Q9GZT9	EGLN1	Egl nine homolog 1	0.058054388	0.008756689	0.037146136	0.032135146	0.0334055385	0.034640641	0.0334055385	0.034640641	0.964345275827892	0.445417	0	1.03697298578198	0.445247	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus	GO:0016706,2-oxoglutarate-dependent dioxygenase activity;GO:0019899,enzyme binding;GO:0008198,ferrous iron binding;GO:0031418,L-ascorbic acid binding;GO:0031545,peptidyl-proline 4-dioxygenase activity;GO:0031543,peptidyl-proline dioxygenase activity;GO:0051213,dioxygenase activity;GO:0005506,iron ion binding;GO:0016705,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0071456,cellular response to hypoxia;GO:0051344,negative regulation of cyclic-nucleotide phosphodiesterase activity;GO:0043433,negative regulation of DNA-binding transcription factor activity;GO:0032364,oxygen homeostasis;GO:0018401,peptidyl-proline hydroxylation to 4-hydroxy-L-proline;GO:0045765,regulation of angiogenesis;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0001666,response to hypoxia;GO:0071731,response to nitric oxide	hsa:54583,path:hsa04066,HIF-1 signaling pathway;hsa:54583,path:hsa05200,Pathways in cancer;hsa:54583,path:hsa05211,Renal cell carcinoma
CLUS_HUMAN	P10909	CLU	Clusterin	3.384991127	1.222220438	3.402221428	19.73912272	2.3036057825	11.570672074	2.3036057825	11.570672074	0.199090058707682	0.015301	-1	5.02285250449531	0.015406	1	GO:0097440,apical dendrite;GO:0072562,blood microparticle;GO:0009986,cell surface;GO:0042583,chromaffin granule;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0097418,neurofibrillary tangle;GO:0005634,nucleus;GO:0099020,perinuclear endoplasmic reticulum lumen;GO:0048471,perinuclear region of cytoplasm;GO:0031093,platelet alpha granule lumen;GO:0032991,protein-containing complex;GO:0034366,spherical high-density lipoprotein particle;GO:0045202,synapse;GO:0031966,mitochondrial membrane;GO:0005783,endoplasmic reticulum	GO:0001540,amyloid-beta binding;GO:0051087,chaperone binding;GO:0050750,low-density lipoprotein particle receptor binding;GO:0051787,misfolded protein binding;GO:0046982,protein heterodimerization activity;GO:0044877,protein-containing complex binding;GO:0005102,signaling receptor binding;GO:0048156,tau protein binding;GO:0031625,ubiquitin protein ligase binding;GO:0051082,unfolded protein binding	GO:0019730,antimicrobial humoral response;GO:0000902,cell morphogenesis;GO:0032286,central nervous system myelin maintenance;GO:0051131,chaperone-mediated protein complex assembly;GO:0061077,chaperone-mediated protein folding;GO:0061741,chaperone-mediated protein transport involved in chaperone-mediated autophagy;GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0002434,immune complex clearance;GO:0045087,innate immune response;GO:0097193,intrinsic apoptotic signaling pathway;GO:0006629,lipid metabolic process;GO:0001774,microglial cell activation;GO:0061518,microglial cell proliferation;GO:1905907,negative regulation of amyloid fibril formation;GO:1902430,negative regulation of amyloid-beta formation;GO:0060548,negative regulation of cell death;GO:1905892,negative regulation of cellular response to thapsigargin;GO:1905895,negative regulation of cellular response to tunicamycin;GO:1902230,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0031333,negative regulation of protein-containing complex assembly;GO:0090201,negative regulation of release of cytochrome c from mitochondria;GO:1903573,negative regulation of response to endoplasmic reticulum stress;GO:0002576,platelet degranulation;GO:1905908,positive regulation of amyloid fibril formation;GO:1902004,positive regulation of amyloid-beta formation;GO:0043065,positive regulation of apoptotic process;GO:0010628,positive regulation of gene expression;GO:2001244,positive regulation of intrinsic apoptotic signaling pathway;GO:1902998,positive regulation of neurofibrillary tangle assembly;GO:1901216,positive regulation of neuron death;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0045429,positive regulation of nitric oxide biosynthetic process;GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0031334,positive regulation of protein-containing complex assembly;GO:0048260,positive regulation of receptor-mediated endocytosis;GO:1902949,positive regulation of tau-protein kinase activity;GO:0032760,positive regulation of tumor necrosis factor production;GO:2000060,positive regulation of ubiquitin-dependent protein catabolic process;GO:0017038,protein import;GO:0050821,protein stabilization;GO:0061740,protein targeting to lysosome involved in chaperone-mediated autophagy;GO:1900221,regulation of amyloid-beta clearance;GO:0042981,regulation of apoptotic process;GO:0042127,regulation of cell population proliferation;GO:0030449,regulation of complement activation;GO:1901214,regulation of neuron death;GO:1902847,regulation of neuronal signal transduction;GO:0001836,release of cytochrome c from mitochondria;GO:0051788,response to misfolded protein;GO:0009615,response to virus;GO:0043691,reverse cholesterol transport	hsa:1191,path:hsa04610,Complement and coagulation cascades
ZC11A_HUMAN	O75152	ZC3H11A	Zinc finger CCCH domain-containing protein 11A	0.449496827	0.170583836	0.390349	0.681230083	0.3100403315	0.5357895415	0.3100403315	0.5357895415	0.578660663349286	0.297480	0	1.7281285273687	0.297770	0	GO:0005654,nucleoplasm	GO:0046872,metal ion binding;GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0016973,poly(A)+ mRNA export from nucleus;GO:0006405,RNA export from nucleus	
LANC1_HUMAN	O43813	LANCL1	Glutathione S-transferase LANCL1	0.342930611	0.664933409	0.791766455	1.029228258	0.50393201	0.9104973565	0.50393201	0.9104973565	0.553468943542177	0.274358	0	1.80678611088825	0.274663	0	GO:0005737,cytoplasm;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane	GO:0004930,G protein-coupled receptor activity;GO:0043295,glutathione binding;GO:0004364,glutathione transferase activity;GO:0050750,low-density lipoprotein particle receptor binding;GO:0017124,SH3 domain binding;GO:0008270,zinc ion binding	GO:0005975,carbohydrate metabolic process;GO:0007186,G protein-coupled receptor signaling pathway;GO:0043523,regulation of neuron apoptotic process;GO:1903203,regulation of oxidative stress-induced neuron death	
CAN1_HUMAN	P07384	CAPN1	Calpain-1 catalytic subunit	10.09977363	11.91112945	14.79783511	16.09410824	11.00545154	15.445971675	11.00545154	15.445971675	0.712512736107941	0.415402	0	1.40348368432323	0.415587	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005925,focal adhesion;GO:0005764,lysosome;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005886,plasma membrane	GO:0005509,calcium ion binding;GO:0004198,calcium-dependent cysteine-type endopeptidase activity;GO:0008233,peptidase activity	GO:0070268,cornification;GO:0022617,extracellular matrix disassembly;GO:0060056,mammary gland involution;GO:0043312,neutrophil degranulation;GO:0008284,positive regulation of cell population proliferation;GO:0006508,proteolysis;GO:0032801,receptor catabolic process;GO:0050790,regulation of catalytic activity;GO:0016241,regulation of macroautophagy;GO:2000310,regulation of NMDA receptor activity;GO:0097264,self proteolysis	hsa:823,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:823,path:hsa04210,Apoptosis;hsa:823,path:hsa04217,Necroptosis;hsa:823,path:hsa04218,Cellular senescence;hsa:823,path:hsa05010,Alzheimer disease;hsa:823,path:hsa05131,Shigellosis
ERAP2_HUMAN	Q6P179	ERAP2	Endoplasmic reticulum aminopeptidase 2	1.120614838	1.384404881	1.457540635	1.499314089	1.2525098595	1.478427362	1.2525098595	1.478427362	0.84719066468414	0.488800	0	1.18037183562785	0.488725	0	GO:0005737,cytoplasm;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0005886,plasma membrane;GO:0005783,endoplasmic reticulum	GO:0004177,aminopeptidase activity;GO:0070006,metalloaminopeptidase activity;GO:0008237,metallopeptidase activity;GO:0042277,peptide binding;GO:0008270,zinc ion binding	GO:0002250,adaptive immune response;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0043171,peptide catabolic process;GO:0006508,proteolysis;GO:0008217,regulation of blood pressure;GO:0007165,signal transduction	
PMVK_HUMAN	Q15126	PMVK	Phosphomevalonate kinase	3.058154064	11.23404784	0.353194227	0.232131295	7.146100952	0.292662761	7.146100952	0.292662761	24.4175272849285	0.002111	1	0.0409541878803282	0.002068	-1	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005777,peroxisome	GO:0005524,ATP binding;GO:0004631,phosphomevalonate kinase activity	GO:0006695,cholesterol biosynthetic process;GO:0019287,isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0019216,regulation of lipid metabolic process;GO:0070723,response to cholesterol;GO:0016126,sterol biosynthetic process	hsa:10654,path:hsa00900,Terpenoid backbone biosynthesis;hsa:10654,path:hsa04146,Peroxisome
COPZ2_HUMAN	Q9P299	COPZ2	Coatomer subunit zeta-2	0.210479242	0.894918743	0.048336047	2.55E-05	0.5526989925	0.0241807735	0.5526989925	0.0241807735	22.8569608205461	0.002513	1	0.0437503484321984	0.002463	-1	GO:0005801,cis-Golgi network;GO:0030126,COPI vesicle coat;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0000139,Golgi membrane;GO:0030133,transport vesicle		GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006891,intra-Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0015031,protein transport	
SF3A2_HUMAN	Q15428	SF3A2	Splicing factor 3A subunit 2	0.306053083	0.052827915	0.16113557	0.221597553	0.179440499	0.1913665615	0.179440499	0.1913665615	0.937679485869845	0.454772	0	1.06646249072234	0.454622	0	GO:0071013,catalytic step 2 spliceosome;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0005686,U2 snRNP;GO:0071005,U2-type precatalytic spliceosome;GO:0071004,U2-type prespliceosome	GO:0003723,RNA binding;GO:0008270,zinc ion binding;GO:0003676,nucleic acid binding	GO:0000389,mRNA 3'-splice site recognition;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0010976,positive regulation of neuron projection development;GO:0000245,spliceosomal complex assembly;GO:1903241,U2-type prespliceosome assembly	hsa:8175,path:hsa03040,Spliceosome
PSME4_HUMAN	Q14997	PSME4	Proteasome activator complex subunit 4	0.447905416	0.345934606	0.510720108	0.239866823	0.396920011	0.3752934655	0.396920011	0.3752934655	1.05762569159361	0.414856	0	0.945514096289794	0.414620	0	GO:0005829,cytosol;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990111,spermatoproteasome complex	GO:0070577,lysine-acetylated histone binding;GO:0016504,peptidase activator activity;GO:0070628,proteasome binding	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0006974,cellular response to DNA damage stimulus;GO:0006281,DNA repair;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0007275,multicellular organism development;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0035093,spermatogenesis, exchange of chromosomal proteins;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:23198,path:hsa03050,Proteasome
GLU2B_HUMAN	P14314	PRKCSH	Glucosidase 2 subunit beta	10.2343777	8.516389172	11.76659283	16.12346889	9.375383436	13.94503086	9.375383436	13.94503086	0.672309981248762	0.381164	0	1.48740912360483	0.381383	0	GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0017177,glucosidase II complex;GO:0043231,intracellular membrane-bounded organelle	GO:0005509,calcium ion binding;GO:0044325,ion channel binding;GO:0051219,phosphoprotein binding;GO:0005080,protein kinase C binding;GO:0044877,protein-containing complex binding;GO:0003723,RNA binding	GO:0044267,cellular protein metabolic process;GO:0035556,intracellular signal transduction;GO:0001889,liver development;GO:0006491,N-glycan processing;GO:0043687,post-translational protein modification;GO:0006457,protein folding;GO:0019082,viral protein processing;GO:0001701,in utero embryonic development;GO:0010977,negative regulation of neuron projection development;GO:0006807,nitrogen compound metabolic process	hsa:5589,path:hsa04141,Protein processing in endoplasmic reticulum
PNPO_HUMAN	Q9NVS9	PNPO	Pyridoxine-5'-phosphate oxidase	0.322585207	0.436442763	0.328501571	0.123853134	0.379513985	0.2261773525	0.379513985	0.2261773525	1.67794865756951	0.272892	0	0.595965791616349	0.272402	0	GO:0005829,cytosol	GO:0010181,FMN binding;GO:0042803,protein homodimerization activity;GO:0030170,pyridoxal phosphate binding;GO:0004733,pyridoxamine-phosphate oxidase activity	GO:0042823,pyridoxal phosphate biosynthetic process;GO:0008615,pyridoxine biosynthetic process;GO:0042816,vitamin B6 metabolic process	hsa:55163,path:hsa00750,Vitamin B6 metabolism
REEP5_HUMAN	Q00765	REEP5	Receptor expression-enhancing protein 5	3.312827197	3.377911557	0.399837667	0.060929027	3.345369377	0.230383347	3.345369377	0.230383347	14.5208819151325	0.007696	1	0.0688663406151577	0.007580	-1	GO:0005783,endoplasmic reticulum;GO:0071782,endoplasmic reticulum tubular network;GO:0016021,integral component of membrane		GO:0007029,endoplasmic reticulum organization;GO:0032386,regulation of intracellular transport	
RT09_HUMAN	P82933	MRPS9	28S ribosomal protein S9, mitochondrial	0.066423124	0.058721112	0.270892069	0.111207323	0.062572118	0.191049696	0.062572118	0.191049696	0.32751749576194	0.080535	0	3.05327200207607	0.080809	0	GO:0005743,mitochondrial inner membrane;GO:0005763,mitochondrial small ribosomal subunit;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0015935,small ribosomal subunit	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0042769,DNA damage response, detection of DNA damage;GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination	hsa:64965,path:hsa03010,Ribosome
XRN2_HUMAN	Q9H0D6	XRN2	5'-3' exoribonuclease 2	0.387067952	0.184325871	0.817479588	3.924014233	0.2856969115	2.3707469105	0.2856969115	2.3707469105	0.120509241300559	0.001698	-1	8.29811879327929	0.001718	1	GO:0016235,aggresome;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0000175,3'-5'-exoribonuclease activity;GO:0008409,5'-3' exonuclease activity;GO:0004534,5'-3' exoribonuclease activity;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0004518,nuclease activity;GO:0003723,RNA binding;GO:0001147,transcription termination site sequence-specific DNA binding	GO:0000738,DNA catabolic process, exonucleolytic;GO:0021766,hippocampus development;GO:0006397,mRNA processing;GO:0030182,neuron differentiation;GO:0000956,nuclear-transcribed mRNA catabolic process;GO:0060041,retina development in camera-type eye;GO:0006401,RNA catabolic process;GO:0016070,RNA metabolic process;GO:0006396,RNA processing;GO:0006364,rRNA processing;GO:0007283,spermatogenesis	hsa:22803,path:hsa03008,Ribosome biogenesis in eukaryotes;hsa:22803,path:hsa03018,RNA degradation
PAK2_HUMAN	Q13177	PAK2	Serine/threonine-protein kinase PAK 2	1.826595231	2.680554054	3.573875124	2.0940138	2.2535746425	2.833944462	2.2535746425	2.833944462	0.795207765260715	0.481710	0	1.25753299161024	0.481821	0	GO:0005911,cell-cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0098978,glutamatergic synapse;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0014069,postsynaptic density	GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0004672,protein kinase activity;GO:0019901,protein kinase binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0030296,protein tyrosine kinase activator activity;GO:0031267,small GTPase binding	GO:0032147,activation of protein kinase activity;GO:0034333,adherens junction assembly;GO:0006915,apoptotic process;GO:0070830,bicellular tight junction assembly;GO:0071407,cellular response to organic cyclic compound;GO:0060996,dendritic spine development;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0035722,interleukin-12-mediated signaling pathway;GO:0043066,negative regulation of apoptotic process;GO:2001271,negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis;GO:0006469,negative regulation of protein kinase activity;GO:0051497,negative regulation of stress fiber assembly;GO:0018105,peptidyl-serine phosphorylation;GO:0016310,phosphorylation;GO:2001238,positive regulation of extrinsic apoptotic signaling pathway;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0046777,protein autophosphorylation;GO:0150105,protein localization to cell-cell junction;GO:0006468,protein phosphorylation;GO:0050770,regulation of axonogenesis;GO:0051493,regulation of cytoskeleton organization;GO:0050690,regulation of defense response to virus by virus;GO:0040008,regulation of growth;GO:0007165,signal transduction;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0031098,stress-activated protein kinase signaling cascade;GO:0031295,T cell costimulation;GO:0050852,T cell receptor signaling pathway;GO:0048010,vascular endothelial growth factor receptor signaling pathway	hsa:5062,path:hsa04014,Ras signaling pathway;hsa:5062,path:hsa04010,MAPK signaling pathway;hsa:5062,path:hsa04012,ErbB signaling pathway;hsa:5062,path:hsa04510,Focal adhesion;hsa:5062,path:hsa04810,Regulation of actin cytoskeleton;hsa:5062,path:hsa04660,T cell receptor signaling pathway;hsa:5062,path:hsa04360,Axon guidance;hsa:5062,path:hsa05211,Renal cell carcinoma;hsa:5062,path:hsa05130,Pathogenic Escherichia coli infection;hsa:5062,path:hsa05170,Human immunodeficiency virus 1 infection
K2C4_HUMAN	P19013	KRT4	Keratin, type II cytoskeletal 4	0.173342886	0.131062939	0.249741812	0.153984113	0.1522029125	0.2018629625	0.1522029125	0.2018629625	0.753991275145385	0.449392	0	1.32627529384498	0.449539	0	GO:0009986,cell surface;GO:0005829,cytosol;GO:0005882,intermediate filament;GO:0045111,intermediate filament cytoskeleton;GO:0045095,keratin filament;GO:0005634,nucleus		GO:0070268,cornification;GO:0007010,cytoskeleton organization;GO:0030855,epithelial cell differentiation;GO:0031424,keratinization;GO:0050680,negative regulation of epithelial cell proliferation	
GIMA1_HUMAN	Q8WWP7	GIMAP1	GTPase IMAP family member 1	0.245905773	0.193064139	1.004375934	0.477205885	0.219484956	0.7407909095	0.219484956	0.7407909095	0.296284623886843	0.060015	0	3.37513296127685	0.060256	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane	GO:0005525,GTP binding		
FABP4_HUMAN	P15090	FABP4	Fatty acid-binding protein, adipocyte	0.206138626	7.309087937	0.388341164	3.617798074	3.7576132815	2.003069619	3.7576132815	2.003069619	1.87592744947923	0.242558	0	0.533069655906793	0.242032	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005811,lipid droplet;GO:0005634,nucleus	GO:0005504,fatty acid binding;GO:0051427,hormone receptor binding;GO:0036041,long-chain fatty acid binding;GO:0005324,long-chain fatty acid transporter activity	GO:0050873,brown fat cell differentiation;GO:0071285,cellular response to lithium ion;GO:0071356,cellular response to tumor necrosis factor;GO:0042632,cholesterol homeostasis;GO:0015909,long-chain fatty acid transport;GO:0006469,negative regulation of protein kinase activity;GO:0045892,negative regulation of transcription, DNA-templated;GO:0120162,positive regulation of cold-induced thermogenesis;GO:0050729,positive regulation of inflammatory response;GO:0009617,response to bacterium;GO:0019433,triglyceride catabolic process;GO:0050872,white fat cell differentiation	hsa:2167,path:hsa04923,Regulation of lipolysis in adipocytes;hsa:2167,path:hsa03320,PPAR signaling pathway
DSG2_HUMAN	Q14126	DSG2	Desmoglein-2	1.213797716	1.162931867	0.69386693	0.825435071	1.1883647915	0.7596510005	1.1883647915	0.7596510005	1.56435625138099	0.292874	0	0.639240581624048	0.292412	0	GO:0016324,apical plasma membrane;GO:0030054,cell junction;GO:0009986,cell surface;GO:0005911,cell-cell junction;GO:0001533,cornified envelope;GO:0030057,desmosome;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0014704,intercalated disc;GO:0043231,intracellular membrane-bounded organelle;GO:0016328,lateral plasma membrane;GO:0005886,plasma membrane	GO:0005509,calcium ion binding;GO:0050839,cell adhesion molecule binding;GO:0086083,cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	GO:0086073,bundle of His cell-Purkinje myocyte adhesion involved in cell communication;GO:0007155,cell adhesion;GO:0098609,cell-cell adhesion;GO:0070268,cornification;GO:0002934,desmosome organization;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0031424,keratinization;GO:0060135,maternal process involved in female pregnancy;GO:0003165,Purkinje myocyte development;GO:0086091,regulation of heart rate by cardiac conduction;GO:0098911,regulation of ventricular cardiac muscle cell action potential;GO:0032570,response to progesterone	hsa:1829,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC)
PRS8_HUMAN	P62195	PSMC5	26S proteasome regulatory subunit 8	2.899529316	1.758029019	3.732955554	3.420533649	2.3287791675	3.5767446015	2.3287791675	3.5767446015	0.651089028420807	0.362629	0	1.53588826773117	0.362866	0	GO:0072562,blood microparticle;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0031597,cytosolic proteasome complex;GO:0070062,extracellular exosome;GO:0016234,inclusion body;GO:0016020,membrane;GO:0031595,nuclear proteasome complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0098794,postsynapse;GO:0022624,proteasome accessory complex;GO:0000502,proteasome complex;GO:0008540,proteasome regulatory particle, base subcomplex	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0036402,proteasome-activating ATPase activity;GO:0017025,TBP-class protein binding;GO:0031531,thyrotropin-releasing hormone receptor binding;GO:0008134,transcription factor binding	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0050804,modulation of chemical synaptic transmission;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0043069,negative regulation of programmed cell death;GO:0045892,negative regulation of transcription, DNA-templated;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0090261,positive regulation of inclusion body assembly;GO:0045899,positive regulation of RNA polymerase II transcription preinitiation complex assembly;GO:0045893,positive regulation of transcription, DNA-templated;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0006357,regulation of transcription by RNA polymerase II;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5705,path:hsa03050,Proteasome;hsa:5705,path:hsa05169,Epstein-Barr virus infection
FABP5_HUMAN	Q01469	FABP5	Fatty acid-binding protein 5	15.01332773	12.80992345	4.413438374	2.039101835	13.91162559	3.2262701045	13.91162559	3.2262701045	4.31198416108932	0.080815	0	0.231911798058964	0.080330	0	GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0030667,secretory granule membrane;GO:0045202,synapse	GO:0005504,fatty acid binding;GO:0042802,identical protein binding;GO:0008289,lipid binding;GO:0005324,long-chain fatty acid transporter activity;GO:0001972,retinoic acid binding	GO:0008544,epidermis development;GO:0042593,glucose homeostasis;GO:0006006,glucose metabolic process;GO:0006629,lipid metabolic process;GO:1990379,lipid transport across blood-brain barrier;GO:0015909,long-chain fatty acid transport;GO:0010829,negative regulation of glucose transmembrane transport;GO:0043312,neutrophil degranulation;GO:0006656,phosphatidylcholine biosynthetic process;GO:0120162,positive regulation of cold-induced thermogenesis;GO:0035360,positive regulation of peroxisome proliferator activated receptor signaling pathway;GO:0031392,regulation of prostaglandin biosynthetic process;GO:0099178,regulation of retrograde trans-synaptic signaling by endocanabinoid;GO:0051930,regulation of sensory perception of pain;GO:0019433,triglyceride catabolic process	hsa:2171,path:hsa03320,PPAR signaling pathway
RRAGA_HUMAN	Q7L523	RRAGA	Ras-related GTP-binding protein A	0.377963785	0.595550823	0.507104126	0.684681627	0.486757304	0.5958928765	0.486757304	0.5958928765	0.816853705080329	0.498077	0	1.22420941936189	0.498170	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:1990131,Gtr1-Gtr2 GTPase complex;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0005634,nucleus;GO:0071986,Ragulator complex	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0051219,phosphoprotein binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0031625,ubiquitin protein ligase binding	GO:0006915,apoptotic process;GO:0007050,cell cycle arrest;GO:0008219,cell death;GO:0034613,cellular protein localization;GO:0034198,cellular response to amino acid starvation;GO:0071230,cellular response to amino acid stimulus;GO:0009267,cellular response to starvation;GO:0019048,modulation by virus of host process;GO:0010507,negative regulation of autophagy;GO:0032008,positive regulation of TOR signaling;GO:1904263,positive regulation of TORC1 signaling;GO:0016567,protein ubiquitination;GO:0010506,regulation of autophagy;GO:0016241,regulation of macroautophagy	hsa:10670,path:hsa04150,mTOR signaling pathway;hsa:10670,path:hsa04140,Autophagy - animal;hsa:10670,path:hsa05131,Shigellosis
NDRG1_HUMAN	Q92597	NDRG1	Protein NDRG1	3.077120264	2.257649338	3.232000384	3.125115702	2.667384801	3.178558043	2.667384801	3.178558043	0.83918077471458	0.491994	0	1.19163835746847	0.491926	0	GO:0005912,adherens junction;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0005874,microtubule;GO:0015630,microtubule cytoskeleton;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane	GO:0045296,cadherin binding;GO:0043015,gamma-tubulin binding;GO:0008017,microtubule binding;GO:0031267,small GTPase binding	GO:0071456,cellular response to hypoxia;GO:0030330,DNA damage response, signal transduction by p53 class mediator;GO:0045576,mast cell activation;GO:0008285,negative regulation of cell population proliferation;GO:0032287,peripheral nervous system myelin maintenance;GO:0099173,postsynapse organization;GO:0042981,regulation of apoptotic process;GO:0010038,response to metal ion;GO:0007165,signal transduction;GO:0042127,regulation of cell population proliferation	
MYH6_HUMAN	P13533	MYH6	Myosin-6	2.55E-05	2.55E-05	2.55E-05	0.180066676	2.55e-005	0.090046088	2.55e-005	0.090046088	0.000283188315743378	0.000000	-1	3531.2191372549	0.000000	1	GO:0005829,cytosol;GO:0005859,muscle myosin complex;GO:0030016,myofibril;GO:0016459,myosin complex;GO:0032982,myosin filament;GO:0030017,sarcomere;GO:0001725,stress fiber;GO:0030018,Z disc	GO:0051015,actin filament binding;GO:0030898,actin-dependent ATPase activity;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0005516,calmodulin binding;GO:0000146,microfilament motor activity;GO:0019901,protein kinase binding	GO:0007512,adult heart development;GO:0046034,ATP metabolic process;GO:0055009,atrial cardiac muscle tissue morphogenesis;GO:0060048,cardiac muscle contraction;GO:0048739,cardiac muscle fiber development;GO:0014898,cardiac muscle hypertrophy in response to stress;GO:0001701,in utero embryonic development;GO:0006936,muscle contraction;GO:0030049,muscle filament sliding;GO:0030239,myofibril assembly;GO:0043462,regulation of ATPase activity;GO:0008217,regulation of blood pressure;GO:0008016,regulation of heart contraction;GO:0060420,regulation of heart growth;GO:0002027,regulation of heart rate;GO:0002026,regulation of the force of heart contraction;GO:0045214,sarcomere organization;GO:0006941,striated muscle contraction;GO:0055010,ventricular cardiac muscle tissue morphogenesis;GO:0007522,visceral muscle development	hsa:4624,path:hsa04022,cGMP-PKG signaling pathway;hsa:4624,path:hsa04919,Thyroid hormone signaling pathway;hsa:4624,path:hsa04260,Cardiac muscle contraction;hsa:4624,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:4624,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:4624,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:4624,path:hsa05416,Viral myocarditis
P3H1_HUMAN	Q32P28	P3H1	Prolyl 3-hydroxylase 1	1.441290043	2.354750081	1.534301999	1.942407361	1.898020062	1.73835468	1.898020062	1.73835468	1.09184856452885	0.404424	0	0.915877927111184	0.404166	0	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0005506,iron ion binding;GO:0031418,L-ascorbic acid binding;GO:0019797,procollagen-proline 3-dioxygenase activity	GO:0060348,bone development;GO:0061077,chaperone-mediated protein folding;GO:0030199,collagen fibril organization;GO:0032963,collagen metabolic process;GO:0008285,negative regulation of cell population proliferation;GO:1901874,negative regulation of post-translational protein modification;GO:0010976,positive regulation of neuron projection development;GO:0006457,protein folding;GO:0018126,protein hydroxylation;GO:0050821,protein stabilization;GO:0050708,regulation of protein secretion	
AP3M1_HUMAN	Q9Y2T2	AP3M1	AP-3 complex subunit mu-1	0.491867925	0.351781919	0.635142929	0.444110261	0.421824922	0.539626595	0.421824922	0.539626595	0.78169779975355	0.471281	0	1.27926674517349	0.471405	0	GO:1904115,axon cytoplasm;GO:0030131,clathrin adaptor complex;GO:0031410,cytoplasmic vesicle;GO:0030659,cytoplasmic vesicle membrane;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0005765,lysosomal membrane;GO:0005764,lysosome	GO:0031267,small GTPase binding	GO:0008089,anterograde axonal transport;GO:0048490,anterograde synaptic vesicle transport;GO:0006897,endocytosis;GO:0006622,protein targeting to lysosome;GO:0016192,vesicle-mediated transport;GO:0016032,viral process	hsa:26985,path:hsa04142,Lysosome
TPR_HUMAN	P12270	TPR	Nucleoprotein TPR	3.001272528	2.534649596	4.288848696	3.97917217	2.767961062	4.134010433	2.767961062	4.134010433	0.669558315553482	0.378777	0	1.49352188863992	0.378999	0	GO:0005737,cytoplasm;GO:0005868,cytoplasmic dynein complex;GO:0019898,extrinsic component of membrane;GO:0043657,host cell;GO:0000776,kinetochore;GO:0072686,mitotic spindle;GO:0005635,nuclear envelope;GO:0042405,nuclear inclusion body;GO:0031965,nuclear membrane;GO:0034399,nuclear periphery;GO:0005643,nuclear pore;GO:0044615,nuclear pore nuclear basket;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003682,chromatin binding;GO:0070840,dynein complex binding;GO:0031072,heat shock protein binding;GO:0051019,mitogen-activated protein kinase binding;GO:0003729,mRNA binding;GO:0042803,protein homodimerization activity;GO:0003723,RNA binding;GO:0017056,structural constituent of nuclear pore;GO:0015631,tubulin binding	GO:0051301,cell division;GO:0034605,cellular response to heat;GO:0035457,cellular response to interferon-alpha;GO:0075733,intracellular transport of virus;GO:0007094,mitotic spindle assembly checkpoint;GO:0006406,mRNA export from nucleus;GO:0031990,mRNA export from nucleus in response to heat stress;GO:0046832,negative regulation of RNA export from nucleus;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045947,negative regulation of translational initiation;GO:0006999,nuclear pore organization;GO:0031453,positive regulation of heterochromatin assembly;GO:0090316,positive regulation of intracellular protein transport;GO:0090267,positive regulation of mitotic cell cycle spindle assembly checkpoint;GO:0046827,positive regulation of protein export from nucleus;GO:0042307,positive regulation of protein import into nucleus;GO:0006606,protein import into nucleus;GO:0016925,protein sumoylation;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0010965,regulation of mitotic sister chromatid separation;GO:1901673,regulation of mitotic spindle assembly;GO:0032880,regulation of protein localization;GO:0070849,response to epidermal growth factor;GO:0006405,RNA export from nucleus;GO:0006404,RNA import into nucleus;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription	hsa:7175,path:hsa03013,RNA transport;hsa:7175,path:hsa05200,Pathways in cancer;hsa:7175,path:hsa05216,Thyroid cancer
RACK1_HUMAN	P63244	RACK1	Receptor of activated protein C kinase 1	17.54328028	17.59179288	18.4971646	8.993529212	17.56753658	13.745346906	17.56753658	13.745346906	1.27807153214384	0.353961	0	0.782428819396829	0.353604	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:1990630,IRE1-RACK1-PP2A complex;GO:0030496,midbody;GO:0005739,mitochondrion;GO:0043025,neuronal cell body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0043204,perikaryon;GO:0048471,perinuclear region of cytoplasm;GO:0001891,phagocytic cup;GO:0015935,small ribosomal subunit	GO:0051434,BH3 domain binding;GO:0045296,cadherin binding;GO:0030332,cyclin binding;GO:0008656,cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0019899,enzyme binding;GO:0008200,ion channel inhibitor activity;GO:0060090,molecular adaptor activity;GO:0042803,protein homodimerization activity;GO:0005080,protein kinase C binding;GO:0019903,protein phosphatase binding;GO:0030292,protein tyrosine kinase inhibitor activity;GO:0030971,receptor tyrosine kinase binding;GO:0043022,ribosome binding;GO:0003723,RNA binding;GO:0042169,SH2 domain binding;GO:0035591,signaling adaptor activity;GO:0005102,signaling receptor binding	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007049,cell cycle;GO:0071333,cellular response to glucose stimulus;GO:0071363,cellular response to growth factor stimulus;GO:0007369,gastrulation;GO:0030308,negative regulation of cell growth;GO:1900102,negative regulation of endoplasmic reticulum unfolded protein response;GO:0010629,negative regulation of gene expression;GO:1903208,negative regulation of hydrogen peroxide-induced neuron death;GO:0033137,negative regulation of peptidyl-serine phosphorylation;GO:0050765,negative regulation of phagocytosis;GO:0032091,negative regulation of protein binding;GO:0051898,negative regulation of protein kinase B signaling;GO:0045879,negative regulation of smoothened signaling pathway;GO:0017148,negative regulation of translation;GO:0030178,negative regulation of Wnt signaling pathway;GO:0043065,positive regulation of apoptotic process;GO:0030335,positive regulation of cell migration;GO:2000304,positive regulation of ceramide biosynthetic process;GO:0051343,positive regulation of cyclic-nucleotide phosphodiesterase activity;GO:2000543,positive regulation of gastrulation;GO:0042998,positive regulation of Golgi to plasma membrane protein transport;GO:0043547,positive regulation of GTPase activity;GO:2001244,positive regulation of intrinsic apoptotic signaling pathway;GO:0051901,positive regulation of mitochondrial depolarization;GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0001934,positive regulation of protein phosphorylation;GO:0031334,positive regulation of protein-containing complex assembly;GO:0016567,protein ubiquitination;GO:0051726,regulation of cell cycle;GO:0051302,regulation of cell division;GO:2000114,regulation of establishment of cell polarity;GO:0032880,regulation of protein localization;GO:0010803,regulation of tumor necrosis factor-mediated signaling pathway;GO:0072344,rescue of stalled ribosome;GO:0048511,rhythmic process;GO:0016032,viral process	hsa:10399,path:hsa05162,Measles
TPSN_HUMAN	O15533	TAPBP	Tapasin	1.895900236	1.098426334	2.107072553	1.423316397	1.497163285	1.765194475	1.497163285	1.765194475	0.848157699451218	0.488417	0	1.17902602387154	0.488341	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0000139,Golgi membrane;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0042824,MHC class I peptide loading complex;GO:0030670,phagocytic vesicle membrane;GO:0016020,membrane	GO:0015433,ABC-type peptide antigen transporter activity;GO:0042288,MHC class I protein binding;GO:0042605,peptide antigen binding;GO:0062061,TAP complex binding;GO:0046978,TAP1 binding;GO:0046979,TAP2 binding;GO:0051082,unfolded protein binding	GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0006955,immune response;GO:0002398,MHC class Ib protein complex assembly;GO:0050823,peptide antigen stabilization;GO:0065003,protein-containing complex assembly;GO:0010468,regulation of gene expression;GO:0061635,regulation of protein complex stability;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:1990668,vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane;GO:0002397,MHC class I protein complex assembly	hsa:6892,path:hsa04612,Antigen processing and presentation;hsa:6892,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:6892,path:hsa05168,Herpes simplex virus 1 infection;hsa:6892,path:hsa05163,Human cytomegalovirus infection;hsa:6892,path:hsa05169,Epstein-Barr virus infection
LKHA4_HUMAN	P09960	LTA4H	Leukotriene A-4 hydrolase	6.932593826	31.13914946	20.02460459	22.88239053	19.035871643	21.45349756	19.035871643	21.45349756	0.887308542104218	0.473261	0	1.12700368873779	0.473152	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1904724,tertiary granule lumen	GO:0004177,aminopeptidase activity;GO:0004301,epoxide hydrolase activity;GO:0004463,leukotriene-A4 hydrolase activity;GO:0070006,metalloaminopeptidase activity;GO:0008233,peptidase activity;GO:0003723,RNA binding;GO:0045148,tripeptide aminopeptidase activity;GO:0008270,zinc ion binding;GO:0016787,hydrolase activity	GO:0044267,cellular protein metabolic process;GO:0019370,leukotriene biosynthetic process;GO:0006691,leukotriene metabolic process;GO:0042759,long-chain fatty acid biosynthetic process;GO:0043312,neutrophil degranulation;GO:0043171,peptide catabolic process	hsa:4048,path:hsa00590,Arachidonic acid metabolism
NRDC_HUMAN	O43847	NRDC	Nardilysin	1.211166533	0.430630704	1.232940807	1.078786865	0.8208986185	1.155863836	0.8208986185	1.155863836	0.710203566313498	0.413469	0	1.40804699868063	0.413655	0	GO:0009986,cell surface;GO:0005829,cytosol;GO:0005739,mitochondrion	GO:0048408,epidermal growth factor binding;GO:0046872,metal ion binding;GO:0004222,metalloendopeptidase activity;GO:0008237,metallopeptidase activity	GO:0120163,negative regulation of cold-induced thermogenesis;GO:0051044,positive regulation of membrane protein ectodomain proteolysis;GO:0052548,regulation of endopeptidase activity	
PLXB2_HUMAN	O15031	PLXNB2	Plexin-B2	0.437318896	0.526369235	0.539434121	0.836366265	0.4818440655	0.687900193	0.4818440655	0.687900193	0.700456360389479	0.405262	0	1.42764068762823	0.405457	0	GO:0009986,cell surface;GO:0070062,extracellular exosome;GO:0005887,integral component of plasma membrane;GO:0002116,semaphorin receptor complex	GO:0017154,semaphorin receptor activity	GO:0007420,brain development;GO:1904861,excitatory synapse assembly;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007162,negative regulation of cell adhesion;GO:0001843,neural tube closure;GO:0007405,neuroblast proliferation;GO:0050772,positive regulation of axonogenesis;GO:0010976,positive regulation of neuron projection development;GO:0045727,positive regulation of translation;GO:0030334,regulation of cell migration;GO:0008360,regulation of cell shape;GO:0043087,regulation of GTPase activity;GO:2001222,regulation of neuron migration;GO:0001932,regulation of protein phosphorylation;GO:0071526,semaphorin-plexin signaling pathway;GO:1902287,semaphorin-plexin signaling pathway involved in axon guidance	hsa:23654,path:hsa04360,Axon guidance
EHD1_HUMAN	Q9H4M9	EHD1	EH domain-containing protein 1	1.25445825	2.150529696	3.094004966	8.846006474	1.702493973	5.97000572	1.702493973	5.97000572	0.285174596616634	0.053367	0	3.50662370303733	0.053593	0	GO:0020018,ciliary pocket membrane;GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0030139,endocytic vesicle;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0005811,lipid droplet;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0031095,platelet dense tubular network membrane;GO:0055038,recycling endosome membrane;GO:0060170,ciliary membrane	GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0005509,calcium ion binding;GO:0005525,GTP binding;GO:0042802,identical protein binding;GO:0031267,small GTPase binding	GO:0007596,blood coagulation;GO:1990090,cellular response to nerve growth factor stimulus;GO:0042632,cholesterol homeostasis;GO:0060271,cilium assembly;GO:0032456,endocytic recycling;GO:0006897,endocytosis;GO:0016197,endosomal transport;GO:0006886,intracellular protein transport;GO:0034383,low-density lipoprotein particle clearance;GO:0031175,neuron projection development;GO:0010886,positive regulation of cholesterol storage;GO:2001137,positive regulation of endocytic recycling;GO:1901741,positive regulation of myoblast fusion;GO:0051260,protein homooligomerization;GO:0061512,protein localization to cilium;GO:0072659,protein localization to plasma membrane;GO:0010976,positive regulation of neuron projection development;GO:0015031,protein transport	hsa:10938,path:hsa04144,Endocytosis
L2HDH_HUMAN	Q9H9P8	L2HGDH	L-2-hydroxyglutarate dehydrogenase, mitochondrial	0.010029094	0.013169722	0.127268777	2.55E-05	0.011599408	0.0636471385	0.011599408	0.0636471385	0.182245553741587	0.010801	-1	5.4871023159113	0.010883	1	GO:0016021,integral component of membrane;GO:0031305,integral component of mitochondrial inner membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion	GO:0003973,(S)-2-hydroxy-acid oxidase activity;GO:0047545,2-hydroxyglutarate dehydrogenase activity;GO:0016491,oxidoreductase activity	GO:0006103,2-oxoglutarate metabolic process;GO:0044267,cellular protein metabolic process	hsa:79944,path:hsa00650,Butanoate metabolism
ADA10_HUMAN	O14672	ADAM10	Disintegrin and metalloproteinase domain-containing protein 10	0.652640274	0.730293568	0.656864525	1.178794233	0.691466921	0.917829379	0.691466921	0.917829379	0.753371963047611	0.448895	0	1.32736556316047	0.449043	0	GO:0005912,adherens junction;GO:0030424,axon;GO:0009986,cell surface;GO:0030136,clathrin-coated vesicle;GO:0005737,cytoplasm;GO:0043197,dendritic spine;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005798,Golgi-associated vesicle;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0043025,neuronal cell body;GO:0005634,nucleus;GO:0097038,perinuclear endoplasmic reticulum;GO:0005886,plasma membrane;GO:0046930,pore complex;GO:0014069,postsynaptic density;GO:0045211,postsynaptic membrane;GO:0035579,specific granule membrane;GO:0097060,synaptic membrane;GO:0008021,synaptic vesicle;GO:0070821,tertiary granule membrane;GO:0097197,tetraspanin-enriched microdomain;GO:0005802,trans-Golgi network	GO:0004175,endopeptidase activity;GO:0005178,integrin binding;GO:0046872,metal ion binding;GO:0004222,metalloendopeptidase activity;GO:1902945,metalloendopeptidase activity involved in amyloid precursor protein catabolic process;GO:0008237,metallopeptidase activity;GO:0042803,protein homodimerization activity;GO:0019901,protein kinase binding;GO:0017124,SH3 domain binding;GO:0005102,signaling receptor binding	GO:0034332,adherens junction organization;GO:1990000,amyloid fibril formation;GO:0042987,amyloid precursor protein catabolic process;GO:0034205,amyloid-beta formation;GO:0007267,cell-cell signaling;GO:0044267,cellular protein metabolic process;GO:0090102,cochlea development;GO:0051089,constitutive protein ectodomain proteolysis;GO:0022617,extracellular matrix disassembly;GO:0001701,in utero embryonic development;GO:0007229,integrin-mediated signaling pathway;GO:0006509,membrane protein ectodomain proteolysis;GO:0042117,monocyte activation;GO:0043066,negative regulation of apoptotic process;GO:0007162,negative regulation of cell adhesion;GO:0071157,negative regulation of cell cycle arrest;GO:0010629,negative regulation of gene expression;GO:0043312,neutrophil degranulation;GO:0035333,Notch receptor processing, ligand-dependent;GO:0007219,Notch signaling pathway;GO:0046931,pore complex assembly;GO:0043065,positive regulation of apoptotic process;GO:0030307,positive regulation of cell growth;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0010820,positive regulation of T cell chemotaxis;GO:0043687,post-translational protein modification;GO:0099173,postsynapse organization;GO:0006468,protein phosphorylation;GO:0016485,protein processing;GO:0061001,regulation of dendritic spine morphogenesis;GO:0098696,regulation of neurotransmitter receptor localization to postsynaptic specialization membrane;GO:0008593,regulation of Notch signaling pathway;GO:1901342,regulation of vasculature development;GO:0097327,response to antineoplastic agent;GO:0034612,response to tumor necrosis factor;GO:0007283,spermatogenesis;GO:1901998,toxin transport	hsa:102,path:hsa05010,Alzheimer disease;hsa:102,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection
HCK_HUMAN	P08631	HCK	Tyrosine-protein kinase HCK	5.015372033	9.50354272	7.192661162	20.64125239	7.2594573765	13.916956776	7.2594573765	13.916956776	0.521626781870807	0.245023	0	1.91707948049277	0.245343	0	GO:0005901,caveola;GO:0042995,cell projection;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0005764,lysosome;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0030133,transport vesicle	GO:0005524,ATP binding;GO:0004715,non-membrane spanning protein tyrosine kinase activity;GO:0001784,phosphotyrosine residue binding;GO:0004713,protein tyrosine kinase activity;GO:0005102,signaling receptor binding;GO:0004714,transmembrane receptor protein tyrosine kinase activity	GO:0007155,cell adhesion;GO:0030154,cell differentiation;GO:0019221,cytokine-mediated signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0002758,innate immune response-activating signal transduction;GO:0007229,integrin-mediated signaling pathway;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0043299,leukocyte degranulation;GO:0002522,leukocyte migration involved in immune response;GO:0031663,lipopolysaccharide-mediated signaling pathway;GO:0007498,mesoderm development;GO:0043066,negative regulation of apoptotic process;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0018108,peptidyl-tyrosine phosphorylation;GO:2000251,positive regulation of actin cytoskeleton reorganization;GO:0030838,positive regulation of actin filament polymerization;GO:0008284,positive regulation of cell population proliferation;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:0008360,regulation of cell shape;GO:0050690,regulation of defense response to virus by virus;GO:0051090,regulation of DNA-binding transcription factor activity;GO:0050727,regulation of inflammatory response;GO:0050764,regulation of phagocytosis;GO:0071801,regulation of podosome assembly;GO:0045728,respiratory burst after phagocytosis;GO:0007169,transmembrane receptor protein tyrosine kinase signaling pathway	hsa:3055,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:3055,path:hsa04062,Chemokine signaling pathway;hsa:3055,path:hsa05130,Pathogenic Escherichia coli infection;hsa:3055,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection
FHR1_HUMAN	Q03591	CFHR1	Complement factor H-related protein 1	0.104677206	0.108523381	0.192712624	0.162036557	0.1066002935	0.1773745905	0.1066002935	0.1773745905	0.600989652460959	0.317820	0	1.663922158901	0.318095	0	GO:0072562,blood microparticle;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0032991,protein-containing complex	GO:0042802,identical protein binding	GO:0006956,complement activation;GO:0051838,cytolysis by host of symbiont cells;GO:0032091,negative regulation of protein binding;GO:0030449,regulation of complement activation	hsa:3078,path:hsa04610,Complement and coagulation cascades
TCPW_HUMAN	Q92526	CCT6B	T-complex protein 1 subunit zeta-2	1.402516581	0.344349632	1.519225164	1.109835959	0.8734331065	1.3145305615	0.8734331065	1.3145305615	0.664444884037791	0.374329	0	1.50501572669664	0.374555	0	GO:0005832,chaperonin-containing T-complex;GO:0005829,cytosol	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0044183,protein folding chaperone;GO:0051082,unfolded protein binding	GO:0006457,protein folding;GO:1901998,toxin transport	
ENAH_HUMAN	Q8N8S7	ENAH	Protein enabled homolog	0.760412345	0.587928819	0.640870003	1.060585279	0.674170582	0.850727641	0.674170582	0.850727641	0.792463474217831	0.479605	0	1.26188781254178	0.479718	0	GO:0030054,cell junction;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0030175,filopodium;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0005886,plasma membrane;GO:0045202,synapse;GO:0042995,cell projection	GO:0003779,actin binding;GO:0005522,profilin binding;GO:0017124,SH3 domain binding;GO:0050699,WW domain binding	GO:0008154,actin polymerization or depolymerization;GO:0070358,actin polymerization-dependent cell motility;GO:0007411,axon guidance	hsa:55740,path:hsa04015,Rap1 signaling pathway;hsa:55740,path:hsa04810,Regulation of actin cytoskeleton;hsa:55740,path:hsa04360,Axon guidance
S2540_HUMAN	Q8TBP6	SLC25A40	Solute carrier family 25 member 40	0.02766982	2.55E-05	0.080117783	2.55E-05	0.01384766	0.0400716415	0.01384766	0.0400716415	0.345572566574294	0.093504	0	2.89374822172122	0.093796	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane		GO:0055085,transmembrane transport	
PDLI2_HUMAN	Q96JY6	PDLIM2	PDZ and LIM domain protein 2	1.820629241	1.966195735	1.169086733	1.938440384	1.893412488	1.5537635585	1.893412488	1.5537635585	1.21859756437324	0.369007	0	0.820615459308199	0.368678	0	GO:0005912,adherens junction;GO:0031941,filamentous actin;GO:0005634,nucleus;GO:0001725,stress fiber;GO:0030018,Z disc	GO:0003779,actin binding;GO:0046872,metal ion binding;GO:0051371,muscle alpha-actinin binding	GO:0030036,actin cytoskeleton organization;GO:0007507,heart development;GO:0061061,muscle structure development	
CAB39_HUMAN	Q9Y376	CAB39	Calcium-binding protein 39	1.885425837	2.383800082	2.824338059	1.657393675	2.1346129595	2.240865867	2.1346129595	2.240865867	0.952583994845596	0.449508	0	1.04977619339709	0.449346	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0034774,secretory granule lumen;GO:1902554,serine/threonine protein kinase complex;GO:0030018,Z disc	GO:0019900,kinase binding;GO:0030295,protein kinase activator activity;GO:0043539,protein serine/threonine kinase activator activity	GO:0007050,cell cycle arrest;GO:0071476,cellular hypotonic response;GO:0035556,intracellular signal transduction;GO:1901380,negative regulation of potassium ion transmembrane transport;GO:1901017,negative regulation of potassium ion transmembrane transporter activity;GO:0043312,neutrophil degranulation;GO:0018105,peptidyl-serine phosphorylation;GO:0010800,positive regulation of peptidyl-threonine phosphorylation;GO:0071902,positive regulation of protein serine/threonine kinase activity;GO:0014823,response to activity;GO:0097066,response to thyroid hormone;GO:0007165,signal transduction	hsa:51719,path:hsa04152,AMPK signaling pathway;hsa:51719,path:hsa04150,mTOR signaling pathway
COIL_HUMAN	P38432	COIL	Coilin	0.031430681	0.0168849	0.020321232	2.55E-05	0.0241577905	0.010173366	0.0241577905	0.010173366	2.37461136265028	0.184917	0	0.421121542551667	0.184349	0	GO:0015030,Cajal body;GO:0001650,fibrillar center;GO:0016020,membrane;GO:0016604,nuclear body;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0042802,identical protein binding;GO:0008022,protein C-terminus binding;GO:0030619,U1 snRNA binding;GO:0030620,U2 snRNA binding	GO:0000387,spliceosomal snRNP assembly	
PRS4_HUMAN	P62191	PSMC1	26S proteasome regulatory subunit 4	1.481051414	0.999221845	2.351507031	1.726616045	1.2401366295	2.039061538	1.2401366295	2.039061538	0.608189898337438	0.324338	0	1.64422329725243	0.324608	0	GO:0005829,cytosol;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0022624,proteasome accessory complex;GO:0000502,proteasome complex;GO:0008540,proteasome regulatory particle, base subcomplex;GO:0005737,cytoplasm	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0036402,proteasome-activating ATPase activity;GO:0003723,RNA binding;GO:0017025,TBP-class protein binding	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:1901215,negative regulation of neuron death;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0006457,protein folding;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5700,path:hsa03050,Proteasome;hsa:5700,path:hsa05203,Viral carcinogenesis;hsa:5700,path:hsa05169,Epstein-Barr virus infection;hsa:5700,path:hsa05165,Human papillomavirus infection
I2BP2_HUMAN	Q7Z5L9	IRF2BP2	Interferon regulatory factor 2-binding protein 2	2.55E-05	0.025981752	0.090713486	2.55E-05	0.013003626	0.045369493	0.013003626	0.045369493	0.286616074814854	0.054209	0	3.4889878407761	0.054437	0	GO:0005737,cytoplasm;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0046872,metal ion binding;GO:0003714,transcription corepressor activity	GO:0002327,immature B cell differentiation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0006357,regulation of transcription by RNA polymerase II	
ITB1_HUMAN	P05556	ITGB1	Integrin beta-1	4.500655345	4.73654236	5.371108712	17.9196175	4.6185988525	11.645363106	4.6185988525	11.645363106	0.396604108473043	0.133717	0	2.52140605363388	0.134042	0	GO:0009986,cell surface;GO:0032154,cleavage furrow;GO:0005737,cytoplasm;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0030175,filopodium;GO:0005925,focal adhesion;GO:0097386,glial cell projection;GO:0034665,integrin alpha1-beta1 complex;GO:0034680,integrin alpha10-beta1 complex;GO:0034681,integrin alpha11-beta1 complex;GO:0034666,integrin alpha2-beta1 complex;GO:0034667,integrin alpha3-beta1 complex;GO:0034668,integrin alpha4-beta1 complex;GO:0034674,integrin alpha5-beta1 complex;GO:0034678,integrin alpha8-beta1 complex;GO:0030027,lamellipodium;GO:0042470,melanosome;GO:0016020,membrane;GO:0045121,membrane raft;GO:0031594,neuromuscular junction;GO:0005886,plasma membrane;GO:0043235,receptor complex;GO:0055037,recycling endosome;GO:0001726,ruffle;GO:0032587,ruffle membrane;GO:0042383,sarcolemma;GO:0008305,integrin complex	GO:0003779,actin binding;GO:0045296,cadherin binding;GO:0050839,cell adhesion molecule binding;GO:0098639,collagen binding involved in cell-matrix adhesion;GO:0015026,coreceptor activity;GO:0001968,fibronectin binding;GO:0005178,integrin binding;GO:0046872,metal ion binding;GO:0002020,protease binding;GO:0046982,protein heterodimerization activity;GO:1990782,protein tyrosine kinase binding;GO:0044877,protein-containing complex binding;GO:0001618,virus receptor activity;GO:0038023,signaling receptor activity	GO:0030183,B cell differentiation;GO:0007161,calcium-independent cell-matrix adhesion;GO:0023035,CD40 signaling pathway;GO:0007155,cell adhesion;GO:0033627,cell adhesion mediated by integrin;GO:0016477,cell migration;GO:0030030,cell projection organization;GO:0033631,cell-cell adhesion mediated by integrin;GO:0007160,cell-matrix adhesion;GO:0031589,cell-substrate adhesion;GO:0006968,cellular defense response;GO:0071404,cellular response to low-density lipoprotein particle stimulus;GO:0019221,cytokine-mediated signaling pathway;GO:0000132,establishment of mitotic spindle orientation;GO:0030198,extracellular matrix organization;GO:0034113,heterotypic cell-cell adhesion;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007229,integrin-mediated signaling pathway;GO:0030032,lamellipodium assembly;GO:0007159,leukocyte cell-cell adhesion;GO:0050900,leukocyte migration;GO:0050901,leukocyte tethering or rolling;GO:0035633,maintenance of blood-brain barrier;GO:0048333,mesodermal cell differentiation;GO:2000811,negative regulation of anoikis;GO:0006909,phagocytosis;GO:0045766,positive regulation of angiogenesis;GO:0043065,positive regulation of apoptotic process;GO:0030335,positive regulation of cell migration;GO:0010763,positive regulation of fibroblast migration;GO:0051951,positive regulation of glutamate uptake involved in transmission of nerve impulse;GO:0043547,positive regulation of GTPase activity;GO:0051897,positive regulation of protein kinase B signaling;GO:1903078,positive regulation of protein localization to plasma membrane;GO:2000273,positive regulation of signaling receptor activity;GO:0090303,positive regulation of wound healing;GO:0150103,reactive gliosis;GO:0031623,receptor internalization;GO:0010710,regulation of collagen catabolic process;GO:0050776,regulation of immune response;GO:1901979,regulation of inward rectifier potassium channel activity;GO:0150003,regulation of spontaneous synaptic transmission;GO:0046718,viral entry into host cell;GO:0019058,viral life cycle	hsa:3688,path:hsa04015,Rap1 signaling pathway;hsa:3688,path:hsa04151,PI3K-Akt signaling pathway;hsa:3688,path:hsa04512,ECM-receptor interaction;hsa:3688,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3688,path:hsa04145,Phagosome;hsa:3688,path:hsa04510,Focal adhesion;hsa:3688,path:hsa04530,Tight junction;hsa:3688,path:hsa04810,Regulation of actin cytoskeleton;hsa:3688,path:hsa04611,Platelet activation;hsa:3688,path:hsa04670,Leukocyte transendothelial migration;hsa:3688,path:hsa04360,Axon guidance;hsa:3688,path:hsa05200,Pathways in cancer;hsa:3688,path:hsa05205,Proteoglycans in cancer;hsa:3688,path:hsa05222,Small cell lung cancer;hsa:3688,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:3688,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:3688,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:3688,path:hsa05130,Pathogenic Escherichia coli infection;hsa:3688,path:hsa05131,Shigellosis;hsa:3688,path:hsa05135,Yersinia infection;hsa:3688,path:hsa05133,Pertussis;hsa:3688,path:hsa05100,Bacterial invasion of epithelial cells;hsa:3688,path:hsa05165,Human papillomavirus infection;hsa:3688,path:hsa05145,Toxoplasmosis;hsa:3688,path:hsa05140,Leishmaniasis
AOFA_HUMAN	P21397	MAOA	Amine oxidase [flavin-containing] A	4.385218412	21.04735963	17.71761787	33.74853224	12.716289021	25.733075055	12.716289021	25.733075055	0.494161268865891	0.219791	0	2.0236308731662	0.220121	0	GO:0005829,cytosol;GO:0016021,integral component of membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion	GO:0097621,monoamine oxidase activity;GO:0008131,primary amine oxidase activity	GO:0006576,cellular biogenic amine metabolic process;GO:0019221,cytokine-mediated signaling pathway;GO:0042420,dopamine catabolic process;GO:0042135,neurotransmitter catabolic process;GO:0042133,neurotransmitter metabolic process;GO:0009967,positive regulation of signal transduction;GO:0006805,xenobiotic metabolic process	hsa:4128,path:hsa00260,Glycine, serine and threonine metabolism;hsa:4128,path:hsa00330,Arginine and proline metabolism;hsa:4128,path:hsa00340,Histidine metabolism;hsa:4128,path:hsa00350,Tyrosine metabolism;hsa:4128,path:hsa00360,Phenylalanine metabolism;hsa:4128,path:hsa00380,Tryptophan metabolism;hsa:4128,path:hsa00982,Drug metabolism - cytochrome P450;hsa:4128,path:hsa04728,Dopaminergic synapse;hsa:4128,path:hsa04726,Serotonergic synapse;hsa:4128,path:hsa05030,Cocaine addiction;hsa:4128,path:hsa05031,Amphetamine addiction;hsa:4128,path:hsa05034,Alcoholism
SC31A_HUMAN	O94979	SEC31A	Protein transport protein Sec31A	6.624035947	6.677344806	8.202416965	5.252320104	6.6506903765	6.7273685345	6.6506903765	6.7273685345	0.988602057757536	0.437155	0	1.01152935314369	0.436966	0	GO:0030127,COPII vesicle coat;GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0048471,perinuclear region of cytoplasm;GO:0030120,vesicle coat	GO:0048306,calcium-dependent protein binding;GO:0005198,structural molecule activity	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0048208,COPII vesicle coating;GO:0090110,COPII-coated vesicle cargo loading;GO:0007029,endoplasmic reticulum organization;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0036498,IRE1-mediated unfolded protein response;GO:0051592,response to calcium ion	hsa:22872,path:hsa04141,Protein processing in endoplasmic reticulum
ATPD_HUMAN	P30049	ATP5F1D	ATP synthase subunit delta, mitochondrial	2.274101713	2.676610697	0.321840461	0.125047609	2.475356205	0.223444035	2.475356205	0.223444035	11.0781932710802	0.014085	1	0.0902674267843403	0.013905	-1	GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0005753,mitochondrial proton-transporting ATP synthase complex;GO:0000275,mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1);GO:0005739,mitochondrion;GO:0045261,proton-transporting ATP synthase complex, catalytic core F(1)	GO:0016887,ATPase activity;GO:0046933,proton-transporting ATP synthase activity, rotational mechanism	GO:0009060,aerobic respiration;GO:0006754,ATP biosynthetic process;GO:0015986,ATP synthesis coupled proton transport;GO:0042407,cristae formation;GO:0042776,mitochondrial ATP synthesis coupled proton transport;GO:0033615,mitochondrial proton-transporting ATP synthase complex assembly;GO:0006119,oxidative phosphorylation;GO:0046688,response to copper ion	hsa:513,path:hsa00190,Oxidative phosphorylation;hsa:513,path:hsa04714,Thermogenesis;hsa:513,path:hsa05010,Alzheimer disease;hsa:513,path:hsa05012,Parkinson disease;hsa:513,path:hsa05016,Huntington disease
MK08_HUMAN	P45983	MAPK8	Mitogen-activated protein kinase 8	0.104080583	0.089215299	0.123874955	0.124293833	0.096647941	0.124084394	0.096647941	0.124084394	0.778888769848044	0.469093	0	1.28388036740483	0.469218	0	GO:0030424,axon;GO:0097441,basal dendrite;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0045202,synapse	GO:0005524,ATP binding;GO:0019899,enzyme binding;GO:0042826,histone deacetylase binding;GO:0035033,histone deacetylase regulator activity;GO:0004705,JUN kinase activity;GO:0004707,MAP kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity	GO:0034198,cellular response to amino acid starvation;GO:0071276,cellular response to cadmium ion;GO:0071345,cellular response to cytokine stimulus;GO:0071222,cellular response to lipopolysaccharide;GO:0071260,cellular response to mechanical stimulus;GO:0034614,cellular response to reactive oxygen species;GO:0006302,double-strand break repair;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0035556,intracellular signal transduction;GO:0007254,JNK cascade;GO:0007258,JUN phosphorylation;GO:0043066,negative regulation of apoptotic process;GO:0032091,negative regulation of protein binding;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:0043065,positive regulation of apoptotic process;GO:0031343,positive regulation of cell killing;GO:0031281,positive regulation of cyclase activity;GO:0090045,positive regulation of deacetylase activity;GO:0010628,positive regulation of gene expression;GO:1900740,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0051247,positive regulation of protein metabolic process;GO:0006468,protein phosphorylation;GO:0042752,regulation of circadian rhythm;GO:1902595,regulation of DNA replication origin binding;GO:0051090,regulation of DNA-binding transcription factor activity;GO:0016241,regulation of macroautophagy;GO:0032880,regulation of protein localization;GO:0009612,response to mechanical stimulus;GO:0006979,response to oxidative stress;GO:0009411,response to UV;GO:0048511,rhythmic process;GO:0051403,stress-activated MAPK cascade	hsa:5599,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:5599,path:hsa04014,Ras signaling pathway;hsa:5599,path:hsa04010,MAPK signaling pathway;hsa:5599,path:hsa04012,ErbB signaling pathway;hsa:5599,path:hsa04310,Wnt signaling pathway;hsa:5599,path:hsa04668,TNF signaling pathway;hsa:5599,path:hsa04068,FoxO signaling pathway;hsa:5599,path:hsa04071,Sphingolipid signaling pathway;hsa:5599,path:hsa04024,cAMP signaling pathway;hsa:5599,path:hsa04140,Autophagy - animal;hsa:5599,path:hsa04137,Mitophagy - animal;hsa:5599,path:hsa04210,Apoptosis;hsa:5599,path:hsa04215,Apoptosis - multiple species;hsa:5599,path:hsa04217,Necroptosis;hsa:5599,path:hsa04510,Focal adhesion;hsa:5599,path:hsa04530,Tight junction;hsa:5599,path:hsa04620,Toll-like receptor signaling pathway;hsa:5599,path:hsa04621,NOD-like receptor signaling pathway;hsa:5599,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:5599,path:hsa04625,C-type lectin receptor signaling pathway;hsa:5599,path:hsa04660,T cell receptor signaling pathway;hsa:5599,path:hsa04658,Th1 and Th2 cell differentiation;hsa:5599,path:hsa04659,Th17 cell differentiation;hsa:5599,path:hsa04657,IL-17 signaling pathway;hsa:5599,path:hsa04664,Fc epsilon RI signaling pathway;hsa:5599,path:hsa04910,Insulin signaling pathway;hsa:5599,path:hsa04920,Adipocytokine signaling pathway;hsa:5599,path:hsa04912,GnRH signaling pathway;hsa:5599,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:5599,path:hsa04917,Prolactin signaling pathway;hsa:5599,path:hsa04926,Relaxin signaling pathway;hsa:5599,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:5599,path:hsa04728,Dopaminergic synapse;hsa:5599,path:hsa04723,Retrograde endocannabinoid signaling;hsa:5599,path:hsa04722,Neurotrophin signaling pathway;hsa:5599,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:5599,path:hsa04380,Osteoclast differentiation;hsa:5599,path:hsa05200,Pathways in cancer;hsa:5599,path:hsa05231,Choline metabolism in cancer;hsa:5599,path:hsa05210,Colorectal cancer;hsa:5599,path:hsa05212,Pancreatic cancer;hsa:5599,path:hsa05017,Spinocerebellar ataxia;hsa:5599,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:5599,path:hsa04930,Type II diabetes mellitus;hsa:5599,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:5599,path:hsa04931,Insulin resistance;hsa:5599,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:5599,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:5599,path:hsa05130,Pathogenic Escherichia coli infection;hsa:5599,path:hsa05132,Salmonella infection;hsa:5599,path:hsa05131,Shigellosis;hsa:5599,path:hsa05135,Yersinia infection;hsa:5599,path:hsa05133,Pertussis;hsa:5599,path:hsa05152,Tuberculosis;hsa:5599,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:5599,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:5599,path:hsa05162,Measles;hsa:5599,path:hsa05161,Hepatitis B;hsa:5599,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:5599,path:hsa05169,Epstein-Barr virus infection;hsa:5599,path:hsa05145,Toxoplasmosis;hsa:5599,path:hsa05142,Chagas disease (American trypanosomiasis);hsa:5599,path:hsa01522,Endocrine resistance
PPT1_HUMAN	P50897	PPT1	Palmitoyl-protein thioesterase 1	0.848211508	0.856070489	1.697135959	0.734789915	0.8521409985	1.215962937	0.8521409985	1.215962937	0.700795207296684	0.405549	0	1.42695039804495	0.405743	0	GO:0030424,axon;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0043202,lysosomal lumen;GO:0005764,lysosome;GO:0016020,membrane;GO:0045121,membrane raft;GO:0005634,nucleus;GO:0008021,synaptic vesicle;GO:0030425,dendrite;GO:0005615,extracellular space;GO:0043025,neuronal cell body	GO:0035727,lysophosphatidic acid binding;GO:0008474,palmitoyl-(protein) hydrolase activity;GO:0016290,palmitoyl-CoA hydrolase activity;GO:0120146,sulfatide binding;GO:0016790,thiolester hydrolase activity	GO:0007420,brain development;GO:0046949,fatty-acyl-CoA biosynthetic process;GO:0016042,lipid catabolic process;GO:0007042,lysosomal lumen acidification;GO:0031579,membrane raft organization;GO:0043066,negative regulation of apoptotic process;GO:0030308,negative regulation of cell growth;GO:0043524,negative regulation of neuron apoptotic process;GO:0007399,nervous system development;GO:0048666,neuron development;GO:0006907,pinocytosis;GO:0048549,positive regulation of pinocytosis;GO:0048260,positive regulation of receptor-mediated endocytosis;GO:0030163,protein catabolic process;GO:0002084,protein depalmitoylation;GO:0015031,protein transport;GO:0006898,receptor-mediated endocytosis;GO:0050803,regulation of synapse structure or activity;GO:0050896,response to stimulus;GO:0030149,sphingolipid catabolic process;GO:0007601,visual perception;GO:0008344,adult locomotory behavior;GO:0008306,associative learning;GO:0044257,cellular protein catabolic process;GO:0007625,grooming behavior;GO:0007040,lysosome organization;GO:0007269,neurotransmitter secretion;GO:0032429,regulation of phospholipase A2 activity	hsa:5538,path:hsa00062,Fatty acid elongation;hsa:5538,path:hsa04142,Lysosome
ABHDA_HUMAN	Q9NUJ1	ABHD10	Palmitoyl-protein thioesterase ABHD10, mitochondrial	7.305100766	6.139205901	9.698162783	18.56892132	6.7221533335	14.1335420515	6.7221533335	14.1335420515	0.475617032800817	0.202888	0	2.10253193438257	0.203222	0	GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0004553,hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0102390,mycophenolic acid acyl-glucuronide esterase activity;GO:0008474,palmitoyl-(protein) hydrolase activity	GO:0052695,cellular glucuronidation;GO:0019391,glucuronoside catabolic process;GO:0002084,protein depalmitoylation	
HNRL2_HUMAN	Q1KMD3	HNRNPUL2	Heterogeneous nuclear ribonucleoprotein U-like protein 2	2.234520207	1.581543358	3.775614364	4.128505637	1.9080317825	3.9520600005	1.9080317825	3.9520600005	0.48279423446471	0.209412	0	2.07127577053345	0.209745	0	GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003723,RNA binding		
MOT1_HUMAN	P53985	SLC16A1	Monocarboxylate transporter 1	0.049017501	0.118779428	0.077594371	0.123287022	0.0838984645	0.1004406965	0.0838984645	0.1004406965	0.835303491747491	0.493551	0	1.19716966333752	0.493486	0	GO:0016324,apical plasma membrane;GO:0009925,basal plasma membrane;GO:0016323,basolateral plasma membrane;GO:0030054,cell junction;GO:0005813,centrosome;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016328,lateral plasma membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0045202,synapse	GO:0046943,carboxylic acid transmembrane transporter activity;GO:0042802,identical protein binding;GO:0015129,lactate transmembrane transporter activity;GO:0015130,mevalonate transmembrane transporter activity;GO:0008028,monocarboxylic acid transmembrane transporter activity;GO:0097159,organic cyclic compound binding;GO:0015293,symporter activity	GO:0051780,behavioral response to nutrient;GO:1905039,carboxylic acid transmembrane transport;GO:0071407,cellular response to organic cyclic compound;GO:0007098,centrosome cycle;GO:0042593,glucose homeostasis;GO:0050900,leukocyte migration;GO:0006629,lipid metabolic process;GO:0015728,mevalonate transport;GO:0015718,monocarboxylic acid transport;GO:0035879,plasma membrane lactate transport;GO:0006090,pyruvate metabolic process;GO:0050796,regulation of insulin secretion;GO:0032094,response to food;GO:0150104,transport across blood-brain barrier	
K1C9_HUMAN	P35527	KRT9	Keratin, type I cytoskeletal 9	331.9543617	46.47531713	164.1575788	267.4131187	189.214839415	215.78534875	189.214839415	215.78534875	0.876866017600743	0.477235	0	1.1404250819711	0.477134	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005882,intermediate filament;GO:0016020,membrane;GO:0005634,nucleus	GO:0005200,structural constituent of cytoskeleton;GO:0005198,structural molecule activity	GO:0070268,cornification;GO:0008544,epidermis development;GO:0045109,intermediate filament organization;GO:0031424,keratinization;GO:0043588,skin development;GO:0007283,spermatogenesis	hsa:3857,path:hsa04915,Estrogen signaling pathway;hsa:3857,path:hsa05150,Staphylococcus aureus infection
ARL1_HUMAN	P40616	ARL1	ADP-ribosylation factor-like protein 1	1.152162305	2.911241178	0.154461094	0.044777557	2.0317017415	0.0996193255	2.0317017415	0.0996193255	20.3946546646715	0.003371	1	0.049032455633203	0.003309	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0005802,trans-Golgi network;GO:0032588,trans-Golgi network membrane	GO:0008047,enzyme activator activity;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0046872,metal ion binding;GO:0019904,protein domain specific binding	GO:0031584,activation of phospholipase D activity;GO:0007030,Golgi organization;GO:0006886,intracellular protein transport;GO:0034067,protein localization to Golgi apparatus;GO:0042147,retrograde transport, endosome to Golgi;GO:0009404,toxin metabolic process;GO:0016192,vesicle-mediated transport;GO:0048193,Golgi vesicle transport	
GCP60_HUMAN	Q9H3P7	ACBD3	Golgi resident protein GCP60	0.952867153	4.99068269	0.793310128	0.986083329	2.9717749215	0.8896967285	2.9717749215	0.8896967285	3.34021113746289	0.118133	0	0.29938227221156	0.117586	0	GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016020,membrane;GO:0005739,mitochondrion	GO:0000062,fatty-acyl-CoA binding;GO:0034237,protein kinase A regulatory subunit binding	GO:0006892,post-Golgi vesicle-mediated transport;GO:0006694,steroid biosynthetic process;GO:0016032,viral process	hsa:64746,path:hsa05132,Salmonella infection
PGM5_HUMAN	Q15124	PGM5	Phosphoglucomutase-like protein 5	0.508807151	0.327106713	0.626361176	1.918697561	0.417956932	1.2725293685	0.417956932	1.2725293685	0.328445804353159	0.081183	0	3.04464233290908	0.081459	0	GO:0005912,adherens junction;GO:0030055,cell-substrate junction;GO:0043034,costamere;GO:0009898,cytoplasmic side of plasma membrane;GO:0005829,cytosol;GO:0016010,dystrophin-associated glycoprotein complex;GO:0005925,focal adhesion;GO:0014704,intercalated disc;GO:0042383,sarcolemma;GO:0005914,spot adherens junction;GO:0001725,stress fiber;GO:0030018,Z disc	GO:0016868,intramolecular transferase activity, phosphotransferases;GO:0000287,magnesium ion binding;GO:0005198,structural molecule activity	GO:0005975,carbohydrate metabolic process;GO:0007155,cell adhesion;GO:0006006,glucose metabolic process;GO:0030239,myofibril assembly;GO:0014706,striated muscle tissue development	
MIRO1_HUMAN	Q8IXI2	RHOT1	Mitochondrial Rho GTPase 1	0.379109221	0.200044271	0.426648848	0.511216047	0.289576746	0.4689324475	0.289576746	0.4689324475	0.617523371529969	0.332751	0	1.61937190736994	0.333014	0	GO:0005829,cytosol;GO:0031307,integral component of mitochondrial outer membrane;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0016021,integral component of membrane	GO:0005509,calcium ion binding;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0019725,cellular homeostasis;GO:0034640,establishment of mitochondrion localization by microtubule attachment;GO:0097345,mitochondrial outer membrane permeabilization;GO:0007005,mitochondrion organization;GO:0047497,mitochondrion transport along microtubule;GO:0016579,protein deubiquitination;GO:0010821,regulation of mitochondrion organization;GO:0046928,regulation of neurotransmitter secretion;GO:1902513,regulation of organelle transport along microtubule;GO:0051056,regulation of small GTPase mediated signal transduction	hsa:55288,path:hsa04137,Mitophagy - animal
S27A3_HUMAN	Q5K4L6	SLC27A3	Solute carrier family 27 member 3	300.2569766	208.4871446	189.0666057	1005.386815	254.3720606	597.22671035	254.3720606	597.22671035	0.425922109965456	0.158655	0	2.34784712181555	0.158988	0	GO:0005783,endoplasmic reticulum;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0031966,mitochondrial membrane;GO:0005739,mitochondrion	GO:0047676,arachidonate-CoA ligase activity;GO:0005524,ATP binding;GO:0005324,long-chain fatty acid transporter activity;GO:0004467,long-chain fatty acid-CoA ligase activity;GO:0031957,very long-chain fatty acid-CoA ligase activity;GO:0000166,nucleotide binding	GO:0015908,fatty acid transport;GO:0001676,long-chain fatty acid metabolic process	hsa:11000,path:hsa04931,Insulin resistance
SHFL_HUMAN	Q9NUL5	SHFL	Shiftless antiviral inhibitor of ribosomal frameshifting protein	0.154945423	0.246647176	0.232482901	0.266364959	0.2007962995	0.24942393	0.2007962995	0.24942393	0.805040236115276	0.489197	0	1.24217393757299	0.489300	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body	GO:0042802,identical protein binding;GO:0043022,ribosome binding;GO:0003723,RNA binding;GO:1990825,sequence-specific mRNA binding	GO:0051607,defense response to virus;GO:0045087,innate immune response;GO:2001125,negative regulation of translational frameshifting;GO:0045071,negative regulation of viral genome replication;GO:0006449,regulation of translational termination;GO:0035456,response to interferon-beta;GO:0034341,response to interferon-gamma;GO:0034340,response to type I interferon;GO:0034342,response to type III interferon;GO:0075523,viral translational frameshifting	
PRDX2_HUMAN	P32119	PRDX2	Peroxiredoxin-2	47.36780242	86.23329484	23.49956249	18.5709913	66.80054863	21.035276895	66.80054863	21.035276895	3.17564389399021	0.126772	0	0.314896768460867	0.126216	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0016209,antioxidant activity;GO:0008379,thioredoxin peroxidase activity;GO:0016491,oxidoreductase activity	GO:0000187,activation of MAPK activity;GO:0045454,cell redox homeostasis;GO:0034599,cellular response to oxidative stress;GO:0002357,defense response to tumor cell;GO:0048872,homeostasis of number of cells;GO:0042744,hydrogen peroxide catabolic process;GO:0045321,leukocyte activation;GO:0043066,negative regulation of apoptotic process;GO:2001240,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0031665,negative regulation of lipopolysaccharide-mediated signaling pathway;GO:0032088,negative regulation of NF-kappaB transcription factor activity;GO:0045581,negative regulation of T cell differentiation;GO:0030194,positive regulation of blood coagulation;GO:0042981,regulation of apoptotic process;GO:0010310,regulation of hydrogen peroxide metabolic process;GO:0019430,removal of superoxide radicals;GO:0002536,respiratory burst involved in inflammatory response;GO:0032496,response to lipopolysaccharide;GO:0006979,response to oxidative stress;GO:0042098,T cell proliferation;GO:0048538,thymus development	
PSME1_HUMAN	Q06323	PSME1	Proteasome activator complex subunit 1	13.1417322	13.36237657	17.15911202	7.228228208	13.252054385	12.193670114	13.252054385	12.193670114	1.08679784356187	0.405939	0	0.920134324818499	0.405684	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0008537,proteasome activator complex;GO:0000502,proteasome complex	GO:0061133,endopeptidase activator activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0010950,positive regulation of endopeptidase activity;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:2000045,regulation of G1/S transition of mitotic cell cycle;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061136,regulation of proteasomal protein catabolic process;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5720,path:hsa03050,Proteasome;hsa:5720,path:hsa04612,Antigen processing and presentation
CEAM6_HUMAN	P40199	CEACAM6	Carcinoembryonic antigen-related cell adhesion molecule 6	5.996157216	1.921611586	3.823109912	3.394324972	3.958884401	3.608717442	3.958884401	3.608717442	1.09703363165112	0.402877	0	0.911549082132444	0.402616	0	GO:0031225,anchored component of membrane;GO:0016324,apical plasma membrane;GO:0035577,azurophil granule membrane;GO:0009986,cell surface;GO:0005615,extracellular space;GO:0005886,plasma membrane	GO:0042802,identical protein binding;GO:0046982,protein heterodimerization activity	GO:0006915,apoptotic process;GO:0007157,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0050900,leukocyte migration;GO:2000811,negative regulation of anoikis;GO:0043312,neutrophil degranulation;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:1904906,positive regulation of endothelial cell-matrix adhesion via fibronectin;GO:0034116,positive regulation of heterotypic cell-cell adhesion;GO:0007165,signal transduction	
RAB35_HUMAN	Q15286	RAB35	Ras-related protein Rab-35	0.662190384	0.997816129	0.118275156	0.036393593	0.8300032565	0.0773343745	0.8300032565	0.0773343745	10.7326562329666	0.015071	1	0.0931735796147446	0.014884	-1	GO:0098993,anchored component of synaptic vesicle membrane;GO:0031253,cell projection membrane;GO:0045334,clathrin-coated endocytic vesicle;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0005905,clathrin-coated pit;GO:0005829,cytosol;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0045171,intercellular bridge;GO:0042470,melanosome;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding	GO:0019882,antigen processing and presentation;GO:1990090,cellular response to nerve growth factor stimulus;GO:0032456,endocytic recycling;GO:0016197,endosomal transport;GO:0000281,mitotic cytokinesis;GO:0031175,neuron projection development;GO:0048227,plasma membrane to endosome transport;GO:0008104,protein localization;GO:0036010,protein localization to endosome;GO:0015031,protein transport;GO:0032482,Rab protein signal transduction	hsa:11021,path:hsa04144,Endocytosis
K1C16_HUMAN	P08779	KRT16	Keratin, type I cytoskeletal 16	14.648148	13.20157865	5.422182792	9.981901864	13.924863325	7.702042328	13.924863325	7.702042328	1.80794427399828	0.252391	0	0.553114393171252	0.251876	0	GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005882,intermediate filament;GO:0005634,nucleus	GO:0005200,structural constituent of cytoskeleton;GO:0005198,structural molecule activity	GO:0007568,aging;GO:0070268,cornification;GO:0007010,cytoskeleton organization;GO:0061436,establishment of skin barrier;GO:0042633,hair cycle;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0045104,intermediate filament cytoskeleton organization;GO:0031424,keratinization;GO:0030216,keratinocyte differentiation;GO:0051546,keratinocyte migration;GO:0002009,morphogenesis of an epithelium;GO:0030336,negative regulation of cell migration	hsa:3868,path:hsa04915,Estrogen signaling pathway;hsa:3868,path:hsa05150,Staphylococcus aureus infection
DC1L1_HUMAN	Q9Y6G9	DYNC1LI1	Cytoplasmic dynein 1 light intermediate chain 1	0.471070995	1.055333018	0.783918148	0.472179728	0.7632020065	0.628048938	0.7632020065	0.628048938	1.21519512305903	0.369897	0	0.822913111667769	0.369569	0	GO:0005813,centrosome;GO:0000777,condensed chromosome kinetochore;GO:0005868,cytoplasmic dynein complex;GO:0005829,cytosol;GO:0101003,ficolin-1-rich granule membrane;GO:0000776,kinetochore;GO:0016020,membrane;GO:0005874,microtubule;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0000922,spindle pole;GO:0005737,cytoplasm	GO:0005524,ATP binding;GO:0045504,dynein heavy chain binding;GO:0019003,GDP binding;GO:0003723,RNA binding	GO:0035973,aggrephagy;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0051301,cell division;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0000226,microtubule cytoskeleton organization;GO:0007018,microtubule-based movement;GO:0007052,mitotic spindle organization;GO:0043312,neutrophil degranulation;GO:0090267,positive regulation of mitotic cell cycle spindle assembly checkpoint;GO:0019058,viral life cycle	hsa:51143,path:hsa04145,Phagosome;hsa:51143,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:51143,path:hsa05132,Salmonella infection
CAVN1_HUMAN	Q6NZI2	CAVIN1	Caveolae-associated protein 1	1.537451633	1.610826518	4.003360087	29.66023432	1.5741390755	16.8317972035	1.5741390755	16.8317972035	0.0935217467551637	0.000455	-1	10.6927001975055	0.000462	1	GO:0005901,caveola;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0043231,intracellular membrane-bounded organelle;GO:0045121,membrane raft;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0032991,protein-containing complex	GO:0042802,identical protein binding;GO:0003723,RNA binding;GO:0042134,rRNA primary transcript binding	GO:2000147,positive regulation of cell motility;GO:0009306,protein secretion;GO:0009303,rRNA transcription;GO:0006363,termination of RNA polymerase I transcription;GO:0006361,transcription initiation from RNA polymerase I promoter	
CLU_HUMAN	O75153	CLUH	Clustered mitochondria protein homolog	0.205645291	0.347143251	0.432384839	2.55E-05	0.276394271	0.2162051695	0.276394271	0.2162051695	1.27838881761798	0.353884	0	0.78223462707011	0.353526	0	GO:0005737,cytoplasm	GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0048312,intracellular distribution of mitochondria;GO:0007005,mitochondrion organization	
PSA7_HUMAN	O14818	PSMA7	Proteasome subunit alpha type-7	9.045596201	8.291066056	8.426930384	7.762145072	8.6683311285	8.094537728	8.6683311285	8.094537728	1.07088649405082	0.410767	0	0.933805781990323	0.410522	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0098794,postsynapse;GO:0000502,proteasome complex;GO:0005839,proteasome core complex;GO:0019773,proteasome core complex, alpha-subunit complex	GO:0004175,endopeptidase activity;GO:0042802,identical protein binding	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0051603,proteolysis involved in cellular protein catabolic process	hsa:5688,path:hsa03050,Proteasome
NTF2_HUMAN	P61970	NUTF2	Nuclear transport factor 2	1.630123523	1.875703325	1.79535351	1.579778969	1.752913424	1.6875662395	1.752913424	1.6875662395	1.03872273749643	0.420791	0	0.962720814613375	0.420567	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005637,nuclear inner membrane;GO:0031965,nuclear membrane;GO:0005640,nuclear outer membrane;GO:0044613,nuclear pore central transport channel;GO:0005654,nucleoplasm	GO:0042802,identical protein binding;GO:0061608,nuclear import signal receptor activity;GO:0031267,small GTPase binding;GO:0017056,structural constituent of nuclear pore	GO:0051028,mRNA transport;GO:1904046,negative regulation of vascular endothelial growth factor production;GO:0006913,nucleocytoplasmic transport;GO:0042307,positive regulation of protein import into nucleus;GO:0006611,protein export from nucleus;GO:0006606,protein import into nucleus;GO:0090204,protein localization to nuclear pore	
RTN4_HUMAN	Q9NQC3	RTN4	Reticulon-4	9.258137853	12.22550468	8.867133537	16.69479743	10.7418212665	12.7809654835	10.7418212665	12.7809654835	0.840454602617267	0.491484	0	1.18983226088107	0.491415	0	GO:0030054,cell junction;GO:0042995,cell projection;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0071782,endoplasmic reticulum tubular network;GO:0098826,endoplasmic reticulum tubular network membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0043025,neuronal cell body;GO:0005635,nuclear envelope;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0016021,integral component of membrane	GO:0045296,cadherin binding;GO:0042803,protein homodimerization activity;GO:0003723,RNA binding;GO:0031625,ubiquitin protein ligase binding	GO:0006915,apoptotic process;GO:0007413,axonal fasciculation;GO:0001825,blastocyst formation;GO:0060317,cardiac epithelial to mesenchymal transition;GO:0120078,cell adhesion involved in sprouting angiogenesis;GO:0035441,cell migration involved in vasculogenesis;GO:0071456,cellular response to hypoxia;GO:0090156,cellular sphingolipid homeostasis;GO:0022009,central nervous system vasculogenesis;GO:0021801,cerebral cortex radial glia guided migration;GO:0007029,endoplasmic reticulum organization;GO:0071787,endoplasmic reticulum tubular network formation;GO:1990809,endoplasmic reticulum tubular network membrane organization;GO:0071786,endoplasmic reticulum tubular network organization;GO:0002523,leukocyte migration involved in inflammatory response;GO:1902430,negative regulation of amyloid-beta formation;GO:0030517,negative regulation of axon extension;GO:0050771,negative regulation of axonogenesis;GO:0030308,negative regulation of cell growth;GO:2001213,negative regulation of vasculogenesis;GO:0051292,nuclear pore complex assembly;GO:0045766,positive regulation of angiogenesis;GO:1905653,positive regulation of artery morphogenesis;GO:0010634,positive regulation of epithelial cell migration;GO:1905580,positive regulation of ERBB3 signaling pathway;GO:2000347,positive regulation of hepatocyte proliferation;GO:0060907,positive regulation of macrophage cytokine production;GO:1905523,positive regulation of macrophage migration;GO:0033601,positive regulation of mammary gland epithelial cell proliferation;GO:1902624,positive regulation of neutrophil migration;GO:0051897,positive regulation of protein kinase B signaling;GO:1905552,positive regulation of protein localization to endoplasmic reticulum;GO:0035022,positive regulation of Rac protein signal transduction;GO:0034165,positive regulation of toll-like receptor 9 signaling pathway;GO:0061462,protein localization to lysosome;GO:0050821,protein stabilization;GO:0042981,regulation of apoptotic process;GO:2000172,regulation of branching morphogenesis of a nerve;GO:0030334,regulation of cell migration	hsa:57142,path:hsa05010,Alzheimer disease
EXOS2_HUMAN	Q13868	EXOSC2	Exosome complex component RRP4	0.076401109	0.050126022	0.063416504	0.140836321	0.0632635655	0.1021264125	0.0632635655	0.1021264125	0.619463309748592	0.334495	0	1.61430061193753	0.334756	0	GO:0005737,cytoplasm;GO:0000177,cytoplasmic exosome (RNase complex);GO:0005829,cytosol;GO:0000178,exosome (RNase complex);GO:0000176,nuclear exosome (RNase complex);GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0000175,3'-5'-exoribonuclease activity;GO:0008312,7S RNA binding;GO:0003723,RNA binding	GO:0071034,CUT catabolic process;GO:0043928,exonucleolytic catabolism of deadenylated mRNA;GO:0000467,exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0071035,nuclear polyadenylation-dependent rRNA catabolic process;GO:0071038,nuclear polyadenylation-dependent tRNA catabolic process;GO:0071049,nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription;GO:0034427,nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';GO:0071051,polyadenylation-dependent snoRNA 3'-end processing;GO:0030307,positive regulation of cell growth;GO:0043488,regulation of mRNA stability;GO:0006364,rRNA processing;GO:0034475,U4 snRNA 3'-end processing	hsa:23404,path:hsa03018,RNA degradation
GARS_HUMAN	P41250	GARS1	Glycine--tRNA ligase	6.732681194	7.967889588	9.592458085	9.518196069	7.350285391	9.555327077	7.350285391	9.555327077	0.769234305824276	0.461517	0	1.29999402318445	0.461652	0	GO:0030424,axon;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0004081,bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity;GO:0004820,glycine-tRNA ligase activity;GO:0042802,identical protein binding;GO:0046983,protein dimerization activity;GO:0016740,transferase activity;GO:0004812,aminoacyl-tRNA ligase activity	GO:0015966,diadenosine tetraphosphate biosynthetic process;GO:0006426,glycyl-tRNA aminoacylation;GO:0070150,mitochondrial glycyl-tRNA aminoacylation;GO:0006418,tRNA aminoacylation for protein translation	hsa:2617,path:hsa00970,Aminoacyl-tRNA biosynthesis
SND1_HUMAN	Q7KZF4	SND1	Staphylococcal nuclease domain-containing protein 1	118.7128341	100.9326624	156.7851842	627.9991979	109.82274825	392.39219105	109.82274825	392.39219105	0.279880055604894	0.050327	0	3.57295913007713	0.050547	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0097433,dense body;GO:0070062,extracellular exosome;GO:0042470,melanosome;GO:0016020,membrane;GO:0005634,nucleus;GO:0016442,RISC complex	GO:0045296,cadherin binding;GO:0004519,endonuclease activity;GO:0004521,endoribonuclease activity;GO:0004518,nuclease activity;GO:1905172,RISC complex binding;GO:0003723,RNA binding;GO:0003712,transcription coregulator activity	GO:0031047,gene silencing by RNA;GO:0010587,miRNA catabolic process;GO:0001649,osteoblast differentiation;GO:0010564,regulation of cell cycle process;GO:0006401,RNA catabolic process;GO:0016032,viral process	hsa:27044,path:hsa05203,Viral carcinogenesis
ACSL1_HUMAN	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	3.394013626	3.921861905	6.865398257	5.161931636	3.6579377655	6.0136649465	3.6579377655	6.0136649465	0.608270962556527	0.324411	0	1.64400417175441	0.324681	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0005778,peroxisomal membrane;GO:0005886,plasma membrane	GO:0047676,arachidonate-CoA ligase activity;GO:0005524,ATP binding;GO:0004467,long-chain fatty acid-CoA ligase activity;GO:0090434,oleoyl-CoA ligase activity;GO:0050197,phytanate-CoA ligase activity;GO:0070251,pristanate-CoA ligase activity;GO:0016874,ligase activity;GO:0000166,nucleotide binding	GO:0033211,adiponectin-activated signaling pathway;GO:0036109,alpha-linolenic acid metabolic process;GO:0015908,fatty acid transport;GO:0043651,linoleic acid metabolic process;GO:0008610,lipid biosynthetic process;GO:0044539,long-chain fatty acid import into cell;GO:0001676,long-chain fatty acid metabolic process;GO:0035338,long-chain fatty-acyl-CoA biosynthetic process;GO:0120162,positive regulation of cold-induced thermogenesis;GO:0010747,positive regulation of long-chain fatty acid import across plasma membrane;GO:0071902,positive regulation of protein serine/threonine kinase activity;GO:0019222,regulation of metabolic process;GO:0042493,response to drug;GO:0007584,response to nutrient;GO:0034201,response to oleic acid;GO:0014070,response to organic cyclic compound;GO:0019432,triglyceride biosynthetic process;GO:0000038,very long-chain fatty acid metabolic process;GO:0042178,xenobiotic catabolic process	hsa:2180,path:hsa00061,Fatty acid biosynthesis;hsa:2180,path:hsa00071,Fatty acid degradation;hsa:2180,path:hsa04146,Peroxisome;hsa:2180,path:hsa04216,Ferroptosis;hsa:2180,path:hsa04920,Adipocytokine signaling pathway;hsa:2180,path:hsa03320,PPAR signaling pathway;hsa:2180,path:hsa04714,Thermogenesis
CAH2_HUMAN	P00918	CA2	Carbonic anhydrase 2	1.97871739	32.79555226	5.968258459	62.22678622	17.387134825	34.0975223395	17.387134825	34.0975223395	0.509923702135331	0.234252	0	1.96107769811925	0.234578	0	GO:0045177,apical part of cell;GO:0030424,axon;GO:0016323,basolateral plasma membrane;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005902,microvillus;GO:0005886,plasma membrane	GO:0004064,arylesterase activity;GO:0004089,carbonate dehydratase activity;GO:0016836,hydro-lyase activity;GO:0008270,zinc ion binding	GO:0038166,angiotensin-activated signaling pathway;GO:0015701,bicarbonate transport;GO:0015670,carbon dioxide transport;GO:0071498,cellular response to fluid shear stress;GO:0001822,kidney development;GO:0042475,odontogenesis of dentin-containing tooth;GO:0006730,one-carbon metabolic process;GO:0045780,positive regulation of bone resorption;GO:0032849,positive regulation of cellular pH reduction;GO:2001150,positive regulation of dipeptide transmembrane transport;GO:0045672,positive regulation of osteoclast differentiation;GO:0044070,regulation of anion transport;GO:0051453,regulation of intracellular pH;GO:0043627,response to estrogen;GO:0009268,response to pH;GO:0048545,response to steroid hormone;GO:0010043,response to zinc ion	hsa:760,path:hsa00910,Nitrogen metabolism;hsa:760,path:hsa04971,Gastric acid secretion;hsa:760,path:hsa04972,Pancreatic secretion;hsa:760,path:hsa04976,Bile secretion;hsa:760,path:hsa04964,Proximal tubule bicarbonate reclamation;hsa:760,path:hsa04966,Collecting duct acid secretion
UBR4_HUMAN	Q5T4S7	UBR4	E3 ubiquitin-protein ligase UBR4	0.238545777	0.251037396	1.696780762	0.261714194	0.2447915865	0.979247478	0.2447915865	0.979247478	0.249979287156254	0.034812	-1	4.00033143295961	0.034990	1	GO:0005813,centrosome;GO:0005829,cytosol;GO:0101003,ficolin-1-rich granule membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0035579,specific granule membrane;GO:0070821,tertiary granule membrane	GO:0005516,calmodulin binding;GO:0061630,ubiquitin protein ligase activity;GO:0004842,ubiquitin-protein transferase activity;GO:0008270,zinc ion binding	GO:0043312,neutrophil degranulation;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0016032,viral process;GO:0016567,protein ubiquitination	hsa:23352,path:hsa05203,Viral carcinogenesis;hsa:23352,path:hsa05165,Human papillomavirus infection
MYO1G_HUMAN	B0I1T2	MYO1G	Unconventional myosin-Ig	0.90738106	1.069554713	2.699846193	1.136774944	0.9884678865	1.9183105685	0.9884678865	1.9183105685	0.515280425772205	0.239180	0	1.9406908354832	0.239503	0	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0030175,filopodium;GO:0030027,lamellipodium;GO:0031256,leading edge membrane;GO:0016020,membrane;GO:0005902,microvillus;GO:0016459,myosin complex;GO:0005654,nucleoplasm;GO:0001891,phagocytic cup;GO:0005886,plasma membrane;GO:0031982,vesicle	GO:0051015,actin filament binding;GO:0030898,actin-dependent ATPase activity;GO:0005524,ATP binding;GO:0005516,calmodulin binding;GO:0000146,microfilament motor activity;GO:0005547,phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325,phosphatidylinositol-3,4-bisphosphate binding;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding;GO:0003779,actin binding;GO:0003774,motor activity	GO:0007015,actin filament organization;GO:0071976,cell gliding;GO:0031589,cell-substrate adhesion;GO:0006887,exocytosis;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0120117,T cell meandering migration;GO:0002456,T cell mediated immunity;GO:0072678,T cell migration;GO:0030050,vesicle transport along actin filament	hsa:64005,path:hsa05130,Pathogenic Escherichia coli infection
A4_HUMAN	P05067	APP	Amyloid-beta precursor protein	0.00969506	2.55E-05	0.035048361	0.017059701	0.00486028	0.026054031	0.00486028	0.026054031	0.186546181663789	0.011859	-1	5.36060288707646	0.011947	1	GO:0106003,amyloid-beta complex;GO:0045177,apical part of cell;GO:0097449,astrocyte projection;GO:0030424,axon;GO:0009986,cell surface;GO:0005911,cell-cell junction;GO:0035253,ciliary rootlet;GO:0005905,clathrin-coated pit;GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043198,dendritic shaft;GO:0043197,dendritic spine;GO:0005769,early endosome;GO:0005788,endoplasmic reticulum lumen;GO:0005768,endosome;GO:0031904,endosome lumen;GO:0070381,endosome to plasma membrane transport vesicle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005794,Golgi apparatus;GO:0005796,Golgi lumen;GO:0005798,Golgi-associated vesicle;GO:1990812,growth cone filopodium;GO:1990761,growth cone lamellipodium;GO:0034364,high-density lipoprotein particle;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0034363,intermediate-density lipoprotein particle;GO:1990777,lipoprotein particle;GO:0044304,main axon;GO:0016020,membrane;GO:0045121,membrane raft;GO:0005739,mitochondrion;GO:0031594,neuromuscular junction;GO:0005641,nuclear envelope lumen;GO:0005634,nucleus;GO:0043204,perikaryon;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0031093,platelet alpha granule lumen;GO:0048786,presynaptic active zone;GO:0032991,protein-containing complex;GO:0043235,receptor complex;GO:0055037,recycling endosome;GO:0005791,rough endoplasmic reticulum;GO:0005790,smooth endoplasmic reticulum;GO:0051233,spindle midzone;GO:0045202,synapse;GO:0008021,synaptic vesicle;GO:0032588,trans-Golgi network membrane;GO:0030426,growth cone	GO:0030549,acetylcholine receptor activator activity;GO:0033130,acetylcholine receptor binding;GO:0097645,amylin binding;GO:0034185,apolipoprotein binding;GO:0051087,chaperone binding;GO:0042056,chemoattractant activity;GO:0003682,chromatin binding;GO:0003677,DNA binding;GO:0019899,enzyme binding;GO:0046875,ephrin receptor binding;GO:0005109,frizzled binding;GO:0001664,G protein-coupled receptor binding;GO:0070851,growth factor receptor binding;GO:1904399,heparan sulfate binding;GO:0043395,heparan sulfate proteoglycan binding;GO:0008201,heparin binding;GO:0042802,identical protein binding;GO:0005158,insulin receptor binding;GO:0005178,integrin binding;GO:0050750,low-density lipoprotein particle receptor binding;GO:0016504,peptidase activator activity;GO:0046983,protein dimerization activity;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0051425,PTB domain binding;GO:0050786,RAGE receptor binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004867,serine-type endopeptidase inhibitor activity;GO:0030546,signaling receptor activator activity;GO:0005102,signaling receptor binding;GO:0046914,transition metal ion binding	GO:0000187,activation of MAPK activity;GO:0000185,activation of MAPKKK activity;GO:0007189,adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193,adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0008344,adult locomotory behavior;GO:1990000,amyloid fibril formation;GO:0019731,antibacterial humoral response;GO:0019732,antifungal humoral response;GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0008306,associative learning;GO:0048143,astrocyte activation;GO:0002265,astrocyte activation involved in immune response;GO:0008088,axo-dendritic transport;GO:0016199,axon midline choice point recognition;GO:0007409,axonogenesis;GO:0019722,calcium-mediated signaling;GO:0007155,cell adhesion;GO:0006878,cellular copper ion homeostasis;GO:0009987,cellular process;GO:0044267,cellular protein metabolic process;GO:1904646,cellular response to amyloid-beta;GO:0071320,cellular response to cAMP;GO:0071280,cellular response to copper ion;GO:0071287,cellular response to manganese ion;GO:1990090,cellular response to nerve growth factor stimulus;GO:0071874,cellular response to norepinephrine stimulus;GO:0008203,cholesterol metabolic process;GO:0050890,cognition;GO:0048669,collateral sprouting in absence of injury;GO:0050829,defense response to Gram-negative bacterium;GO:0050830,defense response to Gram-positive bacterium;GO:0016358,dendrite development;GO:0006897,endocytosis;GO:0030198,extracellular matrix organization;GO:0030900,forebrain development;GO:0007186,G protein-coupled receptor signaling pathway;GO:0045087,innate immune response;GO:0035235,ionotropic glutamate receptor signaling pathway;GO:0007612,learning;GO:0007611,learning or memory;GO:0042157,lipoprotein metabolic process;GO:0007626,locomotory behavior;GO:0007617,mating behavior;GO:0007613,memory;GO:0014005,microglia development;GO:0001774,microglial cell activation;GO:0090647,modulation of age-related behavioral decline;GO:0098815,modulation of excitatory postsynaptic potential;GO:0006378,mRNA polyadenylation;GO:1903523,negative regulation of blood circulation;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0008285,negative regulation of cell population proliferation;GO:0010629,negative regulation of gene expression;GO:1900272,negative regulation of long-term synaptic potentiation;GO:0010823,negative regulation of mitochondrion organization;GO:1901215,negative regulation of neuron death;GO:0045665,negative regulation of neuron differentiation;GO:1902894,negative regulation of pri-miRNA transcription by RNA polymerase II;GO:1900181,negative regulation of protein localization to nucleus;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0050885,neuromuscular process controlling balance;GO:0051402,neuron apoptotic process;GO:0031175,neuron projection development;GO:1990535,neuron projection maintenance;GO:0016322,neuron remodeling;GO:0007219,Notch signaling pathway;GO:0002576,platelet degranulation;GO:0061903,positive regulation of 1-phosphatidylinositol-3-kinase activity;GO:1905908,positive regulation of amyloid fibril formation;GO:0043065,positive regulation of apoptotic process;GO:1902961,positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:0050867,positive regulation of cell activation;GO:1905893,positive regulation of cellular response to thapsigargin;GO:1905896,positive regulation of cellular response to tunicamycin;GO:0032722,positive regulation of chemokine production;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007204,positive regulation of cytosolic calcium ion concentration;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:1904472,positive regulation of endothelin production;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:2000463,positive regulation of excitatory postsynaptic potential;GO:1904022,positive regulation of G protein-coupled receptor internalization;GO:0045745,positive regulation of G protein-coupled receptor signaling pathway;GO:0010971,positive regulation of G2/M transition of mitotic cell cycle;GO:0010628,positive regulation of gene expression;GO:0045821,positive regulation of glycolytic process;GO:0035066,positive regulation of histone acetylation;GO:0050729,positive regulation of inflammatory response;GO:0032729,positive regulation of interferon-gamma production;GO:0032731,positive regulation of interleukin-1 beta production;GO:0032755,positive regulation of interleukin-6 production;GO:0046330,positive regulation of JNK cascade;GO:1900273,positive regulation of long-term synaptic potentiation;GO:0043410,positive regulation of MAPK cascade;GO:0051044,positive regulation of membrane protein ectodomain proteolysis;GO:0045931,positive regulation of mitotic cell cycle;GO:0090026,positive regulation of monocyte chemotaxis;GO:0043525,positive regulation of neuron apoptotic process;GO:1901216,positive regulation of neuron death;GO:0045666,positive regulation of neuron differentiation;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:0045429,positive regulation of nitric oxide biosynthetic process;GO:1903223,positive regulation of oxidative stress-induced neuron death;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0010800,positive regulation of peptidyl-threonine phosphorylation;GO:0042327,positive regulation of phosphorylation;GO:0032092,positive regulation of protein binding;GO:1904591,positive regulation of protein import;GO:0010739,positive regulation of protein kinase A signaling;GO:0051897,positive regulation of protein kinase B signaling;GO:0051247,positive regulation of protein metabolic process;GO:0001934,positive regulation of protein phosphorylation;GO:0061098,positive regulation of protein tyrosine kinase activity;GO:1900122,positive regulation of receptor binding;GO:1905898,positive regulation of response to endoplasmic reticulum stress;GO:0032930,positive regulation of superoxide anion generation;GO:2000406,positive regulation of T cell migration;GO:1902949,positive regulation of tau-protein kinase activity;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0032760,positive regulation of tumor necrosis factor production;GO:0006892,post-Golgi vesicle-mediated transport;GO:0043687,post-translational protein modification;GO:0051260,protein homooligomerization;GO:0045048,protein insertion into ER membrane;GO:0006468,protein phosphorylation;GO:0051262,protein tetramerization;GO:0070206,protein trimerization;GO:0035590,purinergic nucleotide receptor signaling pathway;GO:1903048,regulation of acetylcholine-gated cation channel activity;GO:1905906,regulation of amyloid fibril formation;GO:1900221,regulation of amyloid-beta clearance;GO:1902950,regulation of dendritic spine maintenance;GO:0007176,regulation of epidermal growth factor-activated receptor activity;GO:0010468,regulation of gene expression;GO:0048169,regulation of long-term neuronal synaptic plasticity;GO:0040014,regulation of multicellular organism growth;GO:2000310,regulation of NMDA receptor activity;GO:0050730,regulation of peptidyl-tyrosine phosphorylation;GO:1905606,regulation of presynapse assembly;GO:1905945,regulation of response to calcium ion;GO:0150003,regulation of spontaneous synaptic transmission;GO:0050803,regulation of synapse structure or activity;GO:0034121,regulation of toll-like receptor signaling pathway;GO:0006357,regulation of transcription by RNA polymerase II;GO:0006417,regulation of translation;GO:0030111,regulation of Wnt signaling pathway;GO:0070555,response to interleukin-1;GO:0010288,response to lead ion;GO:0006979,response to oxidative stress;GO:0001878,response to yeast;GO:0051563,smooth endoplasmic reticulum calcium ion homeostasis;GO:0001967,suckling behavior;GO:0050808,synapse organization;GO:0051124,synaptic growth at neuromuscular junction;GO:0008542,visual learning;GO:0007399,nervous system development	hsa:351,path:hsa04726,Serotonergic synapse;hsa:351,path:hsa05010,Alzheimer disease
FPPS_HUMAN	P14324	FDPS	Farnesyl pyrophosphate synthase	3.507288928	1.027979599	3.328931372	2.741624674	2.2676342635	3.035278023	2.2676342635	3.035278023	0.747092769201657	0.443838	0	1.33852185595184	0.443992	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0016021,integral component of membrane	GO:0004161,dimethylallyltranstransferase activity;GO:0004337,geranyltranstransferase activity;GO:0046872,metal ion binding;GO:0003723,RNA binding;GO:0016740,transferase activity	GO:0006695,cholesterol biosynthetic process;GO:0045337,farnesyl diphosphate biosynthetic process;GO:0033384,geranyl diphosphate biosynthetic process;GO:0019216,regulation of lipid metabolic process;GO:0016032,viral process;GO:0008299,isoprenoid biosynthetic process	hsa:2224,path:hsa00900,Terpenoid backbone biosynthesis;hsa:2224,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:2224,path:hsa05164,Influenza A
AGR3_HUMAN	Q8TD06	AGR3	Anterior gradient protein 3	0.039705314	0.063642803	0.088924214	0.052663707	0.0516740585	0.0707939605	0.0516740585	0.0707939605	0.729921848347501	0.429841	0	1.37000968290501	0.430010	0	GO:0005783,endoplasmic reticulum;GO:0043231,intracellular membrane-bounded organelle	GO:0002162,dystroglycan binding	GO:0060548,negative regulation of cell death	
E41L3_HUMAN	Q9Y2J2	EPB41L3	Band 4.1-like protein 3	0.087916286	0.082522506	0.16720151	2.55E-05	0.085219396	0.083613505	0.085219396	0.083613505	1.01920611987262	0.427053	0	0.981155804014382	0.426842	0	GO:0030054,cell junction;GO:0005911,cell-cell junction;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0044224,juxtaparanode region of axon;GO:0033270,paranode region of axon;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0003779,actin binding;GO:0106006,cytoskeletal protein-membrane anchor activity;GO:0005200,structural constituent of cytoskeleton;GO:0008092,cytoskeletal protein binding;GO:0005198,structural molecule activity	GO:0031032,actomyosin structure organization;GO:0006915,apoptotic process;GO:0030866,cortical actin cytoskeleton organization;GO:0030865,cortical cytoskeleton organization;GO:0043217,myelin maintenance;GO:0048812,neuron projection morphogenesis;GO:0030913,paranodal junction assembly;GO:0071205,protein localization to juxtaparanode region of axon;GO:0002175,protein localization to paranode region of axon;GO:0072659,protein localization to plasma membrane;GO:0001558,regulation of cell growth;GO:0008360,regulation of cell shape;GO:0007010,cytoskeleton organization	
VPP1_HUMAN	Q93050	ATP6V0A1	V-type proton ATPase 116 kDa subunit a1	1.198251499	1.206295754	1.806110199	2.039657921	1.2022736265	1.92288406	1.2022736265	1.92288406	0.625244990849838	0.339680	0	1.59937306917212	0.339937	0	GO:0005829,cytosol;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0101003,ficolin-1-rich granule membrane;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005765,lysosomal membrane;GO:0042470,melanosome;GO:0016607,nuclear speck;GO:0048471,perinuclear region of cytoplasm;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0016471,vacuolar proton-transporting V-type ATPase complex;GO:0000220,vacuolar proton-transporting V-type ATPase, V0 domain;GO:0033179,proton-transporting V-type ATPase, V0 domain	GO:0051117,ATPase binding;GO:0046961,proton-transporting ATPase activity, rotational mechanism;GO:0015078,proton transmembrane transporter activity	GO:0008286,insulin receptor signaling pathway;GO:0034220,ion transmembrane transport;GO:0043312,neutrophil degranulation;GO:0090383,phagosome acidification;GO:0016241,regulation of macroautophagy;GO:1901998,toxin transport;GO:0033572,transferrin transport;GO:0007035,vacuolar acidification	hsa:535,path:hsa00190,Oxidative phosphorylation;hsa:535,path:hsa04145,Phagosome;hsa:535,path:hsa04142,Lysosome;hsa:535,path:hsa04966,Collecting duct acid secretion;hsa:535,path:hsa04721,Synaptic vesicle cycle;hsa:535,path:hsa05323,Rheumatoid arthritis;hsa:535,path:hsa05110,Vibrio cholerae infection;hsa:535,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:535,path:hsa05152,Tuberculosis;hsa:535,path:hsa05165,Human papillomavirus infection
PCCA_HUMAN	P05165	PCCA	Propionyl-CoA carboxylase alpha chain, mitochondrial	2.435958536	3.408434416	9.273192602	5.447129297	2.922196476	7.3601609495	2.922196476	7.3601609495	0.39702888239129	0.134071	0	2.5187084475493	0.134395	0	GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0009374,biotin binding;GO:0016421,CoA carboxylase activity;GO:0019899,enzyme binding;GO:0046872,metal ion binding;GO:0004658,propionyl-CoA carboxylase activity	GO:0006768,biotin metabolic process;GO:0019626,short-chain fatty acid catabolic process;GO:0016042,lipid catabolic process	hsa:5095,path:hsa00630,Glyoxylate and dicarboxylate metabolism;hsa:5095,path:hsa00640,Propanoate metabolism;hsa:5095,path:hsa00280,Valine, leucine and isoleucine degradation
FMNL2_HUMAN	Q96PY5	FMNL2	Formin-like protein 2	0.047979012	0.025733021	0.089241963	0.195793436	0.0368560165	0.1425176995	0.0368560165	0.1425176995	0.258606591527251	0.038992	-1	3.86687746083465	0.039183	1	GO:0005829,cytosol	GO:0051015,actin filament binding;GO:0045296,cadherin binding;GO:0031267,small GTPase binding	GO:0016477,cell migration;GO:0030866,cortical actin cytoskeleton organization;GO:0007010,cytoskeleton organization;GO:0022604,regulation of cell morphogenesis;GO:0008360,regulation of cell shape	
BUD31_HUMAN	P41223	BUD31	Protein BUD31 homolog	3.560656273	667.7214339	6.915209023	2.55E-05	335.6410450865	3.4576172615	335.6410450865	3.4576172615	97.0729319360497	0.000029	1	0.0103015328789985	0.000027	-1	GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0071007,U2-type catalytic step 2 spliceosome	GO:0035257,nuclear hormone receptor binding;GO:0030374,nuclear receptor coactivator activity	GO:0000398,mRNA splicing, via spliceosome;GO:2000825,positive regulation of androgen receptor activity;GO:0008380,RNA splicing	hsa:8896,path:hsa03040,Spliceosome
HUWE1_HUMAN	Q7Z6Z7	HUWE1	E3 ubiquitin-protein ligase HUWE1	2.676242188	3.890729121	4.373766865	7.472446291	3.2834856545	5.923106578	3.2834856545	5.923106578	0.554351945429404	0.275171	0	1.80390816383876	0.275476	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0000139,Golgi membrane;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0034774,secretory granule lumen	GO:0003677,DNA binding;GO:0003723,RNA binding;GO:0061630,ubiquitin protein ligase activity;GO:0004842,ubiquitin-protein transferase activity	GO:0006284,base-excision repair;GO:0030154,cell differentiation;GO:0032922,circadian regulation of gene expression;GO:0007030,Golgi organization;GO:0016574,histone ubiquitination;GO:0061025,membrane fusion;GO:0010637,negative regulation of mitochondrial fusion;GO:0043312,neutrophil degranulation;GO:0098779,positive regulation of mitophagy in response to mitochondrial depolarization;GO:0045732,positive regulation of protein catabolic process;GO:1903955,positive regulation of protein targeting to mitochondrion;GO:0031398,positive regulation of protein ubiquitination;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006513,protein monoubiquitination;GO:0000209,protein polyubiquitination;GO:0016567,protein ubiquitination	hsa:10075,path:hsa04120,Ubiquitin mediated proteolysis
TPM3_HUMAN	P06753	TPM3	Tropomyosin alpha-3 chain	2.306304243	1.922964484	2.832308884	1.859365825	2.1146343635	2.3458373545	2.1146343635	2.3458373545	0.901441167454988	0.467962	0	1.10933473653447	0.467841	0	GO:0015629,actin cytoskeleton;GO:0005884,actin filament;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005862,muscle thin filament tropomyosin;GO:0001725,stress fiber	GO:0051015,actin filament binding;GO:0003779,actin binding	GO:0007015,actin filament organization;GO:0006936,muscle contraction;GO:0030049,muscle filament sliding	hsa:7170,path:hsa04260,Cardiac muscle contraction;hsa:7170,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:7170,path:hsa05200,Pathways in cancer;hsa:7170,path:hsa05216,Thyroid cancer;hsa:7170,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:7170,path:hsa05414,Dilated cardiomyopathy (DCM)
F16P2_HUMAN	O00757	FBP2	Fructose-1,6-bisphosphatase isozyme 2	0.650806089	5.055118482	1.152148351	1.517113749	2.8529622855	1.33463105	2.8529622855	1.33463105	2.13764117469019	0.209495	0	0.467805360338332	0.208940	0	GO:0030054,cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0030018,Z disc	GO:0042132,fructose 1,6-bisphosphate 1-phosphatase activity;GO:0042802,identical protein binding;GO:0046872,metal ion binding	GO:0030388,fructose 1,6-bisphosphate metabolic process;GO:0006002,fructose 6-phosphate metabolic process;GO:0006000,fructose metabolic process;GO:0006094,gluconeogenesis;GO:0005986,sucrose biosynthetic process	hsa:8789,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:8789,path:hsa00030,Pentose phosphate pathway;hsa:8789,path:hsa00051,Fructose and mannose metabolism;hsa:8789,path:hsa04152,AMPK signaling pathway;hsa:8789,path:hsa04910,Insulin signaling pathway;hsa:8789,path:hsa04922,Glucagon signaling pathway
UBCP1_HUMAN	Q8WVY7	UBLCP1	Ubiquitin-like domain-containing CTD phosphatase 1	0.379666132	0.349533316	0.458211513	0.203021049	0.364599724	0.330616281	0.364599724	0.330616281	1.10278817152383	0.401172	0	0.906792460983871	0.400907	0	GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0106306,protein serine phosphatase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0106307,protein threonine phosphatase activity	GO:0006470,protein dephosphorylation	
GBP1_HUMAN	P32455	GBP1	Guanylate-binding protein 1	2.885114042	1.895397475	3.041723455	1.653940595	2.3902557585	2.347832025	2.3902557585	2.347832025	1.01806932227189	0.427422	0	0.982251383204857	0.427212	0	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005886,plasma membrane;GO:0012506,vesicle membrane	GO:0003779,actin binding;GO:0019955,cytokine binding;GO:0019899,enzyme binding;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0051879,Hsp90 protein binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:0030507,spectrin binding	GO:0071346,cellular response to interferon-gamma;GO:0071347,cellular response to interleukin-1;GO:0071356,cellular response to tumor necrosis factor;GO:0051607,defense response to virus;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:0032703,negative regulation of interleukin-2 production;GO:1903077,negative regulation of protein localization to plasma membrane;GO:1900025,negative regulation of substrate adhesion-dependent cell spreading;GO:0050860,negative regulation of T cell receptor signaling pathway;GO:0072665,protein localization to vacuole;GO:0050848,regulation of calcium-mediated signaling;GO:1903076,regulation of protein localization to plasma membrane	hsa:2633,path:hsa04621,NOD-like receptor signaling pathway
TCPE_HUMAN	P48643	CCT5	T-complex protein 1 subunit epsilon	12.62846382	9.150375474	13.6286702	9.141950901	10.889419647	11.3853105505	10.889419647	11.3853105505	0.956444674802637	0.448159	0	1.04553878164082	0.447994	0	GO:0044297,cell body;GO:0005813,centrosome;GO:0005832,chaperonin-containing T-complex;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005874,microtubule;GO:0005737,cytoplasm	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0048487,beta-tubulin binding;GO:0031681,G-protein beta-subunit binding;GO:0003730,mRNA 3'-UTR binding;GO:0048027,mRNA 5'-UTR binding;GO:0044183,protein folding chaperone;GO:0051082,unfolded protein binding	GO:0007339,binding of sperm to zona pellucida;GO:1904851,positive regulation of establishment of protein localization to telomere;GO:1904871,positive regulation of protein localization to Cajal body;GO:1904874,positive regulation of telomerase RNA localization to Cajal body;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:0006457,protein folding;GO:0050821,protein stabilization;GO:0009615,response to virus;GO:1901998,toxin transport	
DPYL3_HUMAN	Q14195	DPYSL3	Dihydropyrimidinase-related protein 3	27.28310747	35.29773273	31.54843867	119.7399978	31.2904201	75.644218235	31.2904201	75.644218235	0.413652501540721	0.148088	0	2.41748809997601	0.148418	0	GO:0044297,cell body;GO:0005829,cytosol;GO:0070382,exocytic vesicle;GO:0005615,extracellular space;GO:0031941,filamentous actin;GO:0030426,growth cone;GO:0030027,lamellipodium;GO:0045202,synapse;GO:0005737,cytoplasm	GO:0035374,chondroitin sulfate binding;GO:0031005,filamin binding;GO:0016810,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0042802,identical protein binding;GO:0017124,SH3 domain binding	GO:0051764,actin crosslink formation;GO:0051017,actin filament bundle assembly;GO:0071345,cellular response to cytokine stimulus;GO:0030336,negative regulation of cell migration;GO:0010977,negative regulation of neuron projection development;GO:0048666,neuron development;GO:0051491,positive regulation of filopodium assembly;GO:0010976,positive regulation of neuron projection development;GO:0048678,response to axon injury;GO:0030334,regulation of cell migration;GO:0010975,regulation of neuron projection development	
DDX60_HUMAN	Q8IY21	DDX60	Probable ATP-dependent RNA helicase DDX60	0.238736288	0.119591444	0.272781446	0.194016494	0.179163866	0.23339897	0.179163866	0.23339897	0.767629205904379	0.460250	0	1.30271228909517	0.460386	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0045111,intermediate filament cytoskeleton	GO:0005524,ATP binding;GO:0003690,double-stranded DNA binding;GO:0003725,double-stranded RNA binding;GO:0016787,hydrolase activity;GO:0003724,RNA helicase activity;GO:0003727,single-stranded RNA binding	GO:0051607,defense response to virus;GO:0045087,innate immune response;GO:1900245,positive regulation of MDA-5 signaling pathway;GO:1900246,positive regulation of RIG-I signaling pathway;GO:0009615,response to virus	
TMM70_HUMAN	Q9BUB7	TMEM70	Transmembrane protein 70, mitochondrial	0.462813704	0.613188932	0.012822937	2.55E-05	0.538001318	0.0064242185	0.538001318	0.0064242185	83.745800053345	0.000048	1	0.0119408973269467	0.000046	-1	GO:0032592,integral component of mitochondrial membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0005654,nucleoplasm		GO:0033615,mitochondrial proton-transporting ATP synthase complex assembly	
CLIC6_HUMAN	Q96NY7	CLIC6	Chloride intracellular channel protein 6	0.159393343	0.299442297	0.346812723	0.163101811	0.22941782	0.254957267	0.22941782	0.254957267	0.899828519106302	0.468563	0	1.11132285626287	0.468443	0	GO:0034707,chloride channel complex;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005886,plasma membrane	GO:0005254,chloride channel activity;GO:0031749,D2 dopamine receptor binding;GO:0031750,D3 dopamine receptor binding;GO:0031751,D4 dopamine receptor binding;GO:0005244,voltage-gated ion channel activity	GO:0006821,chloride transport;GO:0034765,regulation of ion transmembrane transport	
XPOT_HUMAN	O43592	XPOT	Exportin-T	0.715614052	0.65754737	1.044591991	0.719457788	0.686580711	0.8820248895	0.686580711	0.8820248895	0.778414213899573	0.468722	0	1.28466307801648	0.468848	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016363,nuclear matrix;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0031267,small GTPase binding;GO:0000049,tRNA binding	GO:0006409,tRNA export from nucleus;GO:0071528,tRNA re-export from nucleus	hsa:11260,path:hsa03013,RNA transport
PLRG1_HUMAN	O43660	PLRG1	Pleiotropic regulator 1	0.124491231	0.12413386	0.173520923	0.099313289	0.1243125455	0.136417106	0.1243125455	0.136417106	0.911268015757496	0.464330	0	1.09737199452649	0.464200	0	GO:0071013,catalytic step 2 spliceosome;GO:0080008,Cul4-RING E3 ubiquitin ligase complex;GO:0001650,fibrillar center;GO:0031965,nuclear membrane;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000974,Prp19 complex;GO:0071007,U2-type catalytic step 2 spliceosome;GO:0016021,integral component of membrane		GO:0000398,mRNA splicing, via spliceosome;GO:1900087,positive regulation of G1/S transition of mitotic cell cycle;GO:0034504,protein localization to nucleus	hsa:5356,path:hsa03040,Spliceosome
ACOT9_HUMAN	Q9Y305	ACOT9	Acyl-coenzyme A thioesterase 9, mitochondrial	1.961329355	2.561225814	1.930245353	2.230760756	2.2612775845	2.0805030545	2.2612775845	2.0805030545	1.08688981715696	0.405911	0	0.920056462223336	0.405656	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0003986,acetyl-CoA hydrolase activity;GO:0047617,acyl-CoA hydrolase activity;GO:0052689,carboxylic ester hydrolase activity;GO:0016787,hydrolase activity	GO:0006637,acyl-CoA metabolic process	
PABP1_HUMAN	P11940	PABPC1	Polyadenylate-binding protein 1	10.34767563	12.73309782	14.77924518	7.6584678	11.540386725	11.21885649	11.540386725	11.21885649	1.02865980461436	0.424002	0	0.972138694944818	0.423785	0	GO:0071013,catalytic step 2 spliceosome;GO:0031252,cell leading edge;GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0016020,membrane;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex	GO:0003730,mRNA 3'-UTR binding;GO:0008143,poly(A) binding;GO:0008266,poly(U) RNA binding;GO:0008022,protein C-terminus binding;GO:0003723,RNA binding;GO:0008494,translation activator activity;GO:0003676,nucleic acid binding	GO:0031047,gene silencing by RNA;GO:0006378,mRNA polyadenylation;GO:0000398,mRNA splicing, via spliceosome;GO:0048255,mRNA stabilization;GO:2000623,negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:1900153,positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0060213,positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0045070,positive regulation of viral genome replication;GO:0043488,regulation of mRNA stability;GO:0006413,translational initiation	hsa:26986,path:hsa03013,RNA transport;hsa:26986,path:hsa03015,mRNA surveillance pathway;hsa:26986,path:hsa03018,RNA degradation
NDKB_HUMAN	P22392	NME2	Nucleoside diphosphate kinase B	18.43868326	21.8381077	2.059907971	0.187052597	20.13839548	1.123480284	20.13839548	1.123480284	17.9250101375166	0.004654	1	0.0557879740278097	0.004574	-1	GO:0071944,cell periphery;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005882,intermediate filament;GO:0030027,lamellipodium;GO:0031966,mitochondrial membrane;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0001726,ruffle;GO:0034774,secretory granule lumen	GO:0005524,ATP binding;GO:0003677,DNA binding;GO:0019899,enzyme binding;GO:0005504,fatty acid binding;GO:0051880,G-quadruplex DNA binding;GO:0019003,GDP binding;GO:0042802,identical protein binding;GO:0019215,intermediate filament binding;GO:0046872,metal ion binding;GO:0004550,nucleoside diphosphate kinase activity;GO:0004673,protein histidine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0003713,transcription coactivator activity	GO:0007189,adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007155,cell adhesion;GO:0071398,cellular response to fatty acid;GO:0071333,cellular response to glucose stimulus;GO:0034599,cellular response to oxidative stress;GO:0006241,CTP biosynthetic process;GO:0006183,GTP biosynthetic process;GO:0007229,integrin-mediated signaling pathway;GO:0043066,negative regulation of apoptotic process;GO:0002762,negative regulation of myeloid leukocyte differentiation;GO:0043312,neutrophil degranulation;GO:0015949,nucleobase-containing small molecule interconversion;GO:0006165,nucleoside diphosphate phosphorylation;GO:0009142,nucleoside triphosphate biosynthetic process;GO:0050679,positive regulation of epithelial cell proliferation;GO:0045618,positive regulation of keratinocyte differentiation;GO:0010976,positive regulation of neuron projection development;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0046777,protein autophosphorylation;GO:0042981,regulation of apoptotic process;GO:0045682,regulation of epidermis development;GO:0060416,response to growth hormone;GO:0006228,UTP biosynthetic process	hsa:4831,path:hsa00230,Purine metabolism;hsa:4831,path:hsa00240,Pyrimidine metabolism;hsa:4831,path:hsa00983,Drug metabolism - other enzymes;hsa:654364,path:hsa00230,Purine metabolism;hsa:654364,path:hsa00240,Pyrimidine metabolism;hsa:654364,path:hsa00983,Drug metabolism - other enzymes
RFC5_HUMAN	P40937	RFC5	Replication factor C subunit 5	2.55E-05	0.02504754	0.038609972	2.55E-05	0.01253652	0.019317736	0.01253652	0.019317736	0.648964247156085	0.360757	0	1.54091693707664	0.360995	0	GO:0031390,Ctf18 RFC-like complex;GO:0005663,DNA replication factor C complex;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0003677,DNA binding;GO:0019899,enzyme binding	GO:0006287,base-excision repair, gap-filling;GO:0042769,DNA damage response, detection of DNA damage;GO:0032508,DNA duplex unwinding;GO:0006281,DNA repair;GO:0006260,DNA replication;GO:0006261,DNA-dependent DNA replication;GO:0070987,error-free translesion synthesis;GO:0042276,error-prone translesion synthesis;GO:0006297,nucleotide-excision repair, DNA gap filling;GO:0033683,nucleotide-excision repair, DNA incision;GO:0006296,nucleotide-excision repair, DNA incision, 5'-to lesion;GO:1900264,positive regulation of DNA-directed DNA polymerase activity;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0032201,telomere maintenance via semi-conservative replication;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0019985,translesion synthesis	hsa:5985,path:hsa03030,DNA replication;hsa:5985,path:hsa03420,Nucleotide excision repair;hsa:5985,path:hsa03430,Mismatch repair
RTCA_HUMAN	O00442	RTCA	RNA 3'-terminal phosphate cyclase	13.79329356	12.41815864	11.8472322	8.547707848	13.1057261	10.197470024	13.1057261	10.197470024	1.28519388330197	0.352221	0	0.778092716587446	0.351860	0	GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0003723,RNA binding;GO:0003963,RNA-3'-phosphate cyclase activity	GO:0006396,RNA processing	
MYO9B_HUMAN	Q13459	MYO9B	Unconventional myosin-IXb	0.126245402	0.0406927	0.206025553	0.141705228	0.083469051	0.1738653905	0.083469051	0.1738653905	0.480078587003202	0.206941	0	2.08299229974473	0.207274	0	GO:0015629,actin cytoskeleton;GO:0005884,actin filament;GO:0005938,cell cortex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0016459,myosin complex;GO:0048471,perinuclear region of cytoplasm	GO:0003779,actin binding;GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0005516,calmodulin binding;GO:0005096,GTPase activator activity;GO:0046872,metal ion binding;GO:0000146,microfilament motor activity;GO:0048495,Roundabout binding;GO:0031267,small GTPase binding	GO:0030048,actin filament-based movement;GO:0035023,regulation of Rho protein signal transduction;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007266,Rho protein signal transduction;GO:0035385,Roundabout signaling pathway;GO:0043547,positive regulation of GTPase activity	
LV319_HUMAN	P01714	IGLV3-19	Immunoglobulin lambda variable 3-19	0.993918635	0.010355198	0.169129381	0.844431019	0.5021369165	0.5067802	0.5021369165	0.5067802	0.990837677754577	0.436405	0	1.0092470466668	0.436215	0	GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0070062,extracellular exosome;GO:0072562,blood microparticle	GO:0003823,antigen binding	GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
SEPT9_HUMAN	Q9UHD8	SEPTIN9	Septin-9	3.601768974	4.36170107	5.629859517	7.099708384	3.981735022	6.3647839505	3.981735022	6.3647839505	0.625588402209191	0.339987	0	1.59849510711615	0.340244	0	GO:0015629,actin cytoskeleton;GO:0005930,axoneme;GO:0032153,cell division site;GO:0005737,cytoplasm;GO:0005874,microtubule;GO:0015630,microtubule cytoskeleton;GO:0097730,non-motile cilium;GO:0048471,perinuclear region of cytoplasm;GO:0031105,septin complex;GO:0005940,septin ring;GO:0001725,stress fiber;GO:0005856,cytoskeleton	GO:0045296,cadherin binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0060090,molecular adaptor activity	GO:0034613,cellular protein localization;GO:0061640,cytoskeleton-dependent cytokinesis;GO:1902857,positive regulation of non-motile cilium assembly	hsa:10801,path:hsa05131,Shigellosis;hsa:10801,path:hsa05100,Bacterial invasion of epithelial cells
RM11_HUMAN	Q9Y3B7	MRPL11	39S ribosomal protein L11, mitochondrial	0.260683796	0.607244919	0.034958119	0.004097948	0.4339643575	0.0195280335	0.4339643575	0.0195280335	22.2226348341731	0.002704	1	0.044999164476313	0.002652	-1	GO:0015934,large ribosomal subunit;GO:0005743,mitochondrial inner membrane;GO:0005762,mitochondrial large ribosomal subunit;GO:0005761,mitochondrial ribosome;GO:0005739,mitochondrion;GO:0005840,ribosome	GO:0070180,large ribosomal subunit rRNA binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination;GO:0006412,translation	hsa:65003,path:hsa03010,Ribosome
BZW1_HUMAN	Q7L1Q6	BZW1	Basic leucine zipper and W2 domain-containing protein 1	3.223994517	2.087223761	1.99423728	2.055248292	2.655609139	2.024742786	2.655609139	2.024742786	1.31157851622542	0.345883	0	0.762440058013372	0.345510	0	GO:0005737,cytoplasm;GO:0016020,membrane	GO:0045296,cadherin binding;GO:0003723,RNA binding		
CSN5_HUMAN	Q92905	COPS5	COP9 signalosome complex subunit 5	0.74693754	0.692869828	1.145087388	1.207126942	0.719903684	1.176107165	0.719903684	1.176107165	0.612107217287466	0.327874	0	1.63370071738652	0.328141	0	GO:0008180,COP9 signalosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005852,eukaryotic translation initiation factor 3 complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0008021,synaptic vesicle	GO:0019899,enzyme binding;GO:0070122,isopeptidase activity;GO:0035718,macrophage migration inhibitory factor binding;GO:0046872,metal ion binding;GO:0004222,metalloendopeptidase activity;GO:0008237,metallopeptidase activity;GO:0019784,NEDD8-specific protease activity;GO:0004843,thiol-dependent deubiquitinase;GO:0003713,transcription coactivator activity;GO:0003743,translation initiation factor activity	GO:1990182,exosomal secretion;GO:0043066,negative regulation of apoptotic process;GO:0000715,nucleotide-excision repair, DNA damage recognition;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0043687,post-translational protein modification;GO:0000338,protein deneddylation;GO:0016579,protein deubiquitination;GO:0051726,regulation of cell cycle;GO:1903894,regulation of IRE1-mediated unfolded protein response;GO:0046328,regulation of JNK cascade;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0006412,translation	
DHX9_HUMAN	Q08211	DHX9	ATP-dependent RNA helicase A	15.12997629	11.00891142	16.93994943	15.55481524	13.069443855	16.247382335	13.069443855	16.247382335	0.804403046935499	0.488714	0	1.24315789679025	0.488818	0	GO:0015629,actin cytoskeleton;GO:0005813,centrosome;GO:0070937,CRD-mediated mRNA stability complex;GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0016020,membrane;GO:0016604,nuclear body;GO:0097165,nuclear stress granule;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005726,perichromatin fibrils;GO:0042788,polysomal ribosome;GO:0005844,polysome;GO:0032991,protein-containing complex;GO:1990904,ribonucleoprotein complex;GO:0016442,RISC complex;GO:0070578,RISC-loading complex	GO:0043138,3'-5' DNA helicase activity;GO:0033679,3'-5' DNA/RNA helicase activity;GO:0034458,3'-5' RNA helicase activity;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0031490,chromatin DNA binding;GO:0003677,DNA binding;GO:0003678,DNA helicase activity;GO:0003688,DNA replication origin binding;GO:0003690,double-stranded DNA binding;GO:0003725,double-stranded RNA binding;GO:0061676,importin-alpha family protein binding;GO:0046872,metal ion binding;GO:0003729,mRNA binding;GO:0017111,nucleoside-triphosphatase activity;GO:0047429,nucleoside-triphosphate diphosphatase activity;GO:1905538,polysome binding;GO:1990841,promoter-specific chromatin binding;GO:0001069,regulatory region RNA binding;GO:1905172,RISC complex binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0070063,RNA polymerase binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000993,RNA polymerase II complex binding;GO:0001085,RNA polymerase II transcription factor binding;GO:0035613,RNA stem-loop binding;GO:1990825,sequence-specific mRNA binding;GO:1990518,single-stranded 3'-5' DNA helicase activity;GO:0003697,single-stranded DNA binding;GO:0003727,single-stranded RNA binding;GO:0035197,siRNA binding;GO:0003713,transcription coactivator activity;GO:0003712,transcription coregulator activity;GO:0045142,triplex DNA binding	GO:0000380,alternative mRNA splicing, via spliceosome;GO:0034622,cellular protein-containing complex assembly;GO:0071360,cellular response to exogenous dsRNA;GO:0071356,cellular response to tumor necrosis factor;GO:0070934,CRD-mediated mRNA stabilization;GO:0032508,DNA duplex unwinding;GO:0006260,DNA replication;GO:0006353,DNA-templated transcription, termination;GO:0039695,DNA-templated viral transcription;GO:0044806,G-quadruplex DNA unwinding;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0000398,mRNA splicing, via spliceosome;GO:0051028,mRNA transport;GO:0001649,osteoblast differentiation;GO:2000767,positive regulation of cytoplasmic translation;GO:0045739,positive regulation of DNA repair;GO:0045740,positive regulation of DNA replication;GO:2000373,positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;GO:0048146,positive regulation of fibroblast proliferation;GO:2000637,positive regulation of gene silencing by miRNA;GO:0050729,positive regulation of inflammatory response;GO:0045089,positive regulation of innate immune response;GO:0032727,positive regulation of interferon-alpha production;GO:0032728,positive regulation of interferon-beta production;GO:0032741,positive regulation of interleukin-18 production;GO:0032755,positive regulation of interleukin-6 production;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:1905698,positive regulation of polysome binding;GO:0060760,positive regulation of response to cytokine stimulus;GO:0046833,positive regulation of RNA export from nucleus;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0032760,positive regulation of tumor necrosis factor production;GO:0032481,positive regulation of type I interferon production;GO:0050434,positive regulation of viral transcription;GO:1904973,positive regulation of viral translation;GO:1903608,protein localization to cytoplasmic stress granule;GO:0070269,pyroptosis;GO:2000765,regulation of cytoplasmic translation;GO:0050691,regulation of defense response to virus by host;GO:0050684,regulation of mRNA processing;GO:0006357,regulation of transcription by RNA polymerase II;GO:0048511,rhythmic process;GO:0010501,RNA secondary structure unwinding;GO:0070922,small RNA loading onto RISC;GO:0030423,targeting of mRNA for destruction involved in RNA interference	
RAB1B_HUMAN	Q9H0U4	RAB1B	Ras-related protein Rab-1B	0.668884519	3.900664581	0.229791529	0.479717994	2.28477455	0.3547547615	2.28477455	0.3547547615	6.44043378118267	0.041126	1	0.155269044597858	0.040775	-1	GO:0005829,cytosol;GO:0012505,endomembrane system;GO:0005789,endoplasmic reticulum membrane;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0048471,perinuclear region of cytoplasm;GO:0034045,phagophore assembly site membrane;GO:0030133,transport vesicle	GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0000045,autophagosome assembly;GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:1903020,positive regulation of glycoprotein metabolic process;GO:0043687,post-translational protein modification;GO:2000785,regulation of autophagosome assembly;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0019068,virion assembly	hsa:81876,path:hsa05134,Legionellosis
ANXA5_HUMAN	P08758	ANXA5	Annexin A5	48.83911192	130.2143844	30.25270196	77.67404067	89.52674816	53.963371315	89.52674816	53.963371315	1.6590280773491	0.276078	0	0.602762553360678	0.275592	0	GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005925,focal adhesion;GO:0016020,membrane	GO:0005509,calcium ion binding;GO:0005544,calcium-dependent phospholipid binding;GO:0004859,phospholipase inhibitor activity;GO:0005543,phospholipid binding	GO:0007596,blood coagulation;GO:0043066,negative regulation of apoptotic process;GO:0050819,negative regulation of coagulation;GO:0002576,platelet degranulation;GO:0007165,signal transduction	
CK5P3_HUMAN	Q96JB5	CDK5RAP3	CDK5 regulatory subunit-associated protein 3	0.817605913	0.349892327	1.003665229	0.766626827	0.58374912	0.885146028	0.58374912	0.885146028	0.659494706561571	0.370006	0	1.51631239803839	0.370236	0	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0030332,cyclin binding;GO:0097371,MDM2/MDM4 family protein binding;GO:0051019,mitogen-activated protein kinase binding;GO:0051059,NF-kappaB binding;GO:0019901,protein kinase binding;GO:0044389,ubiquitin-like protein ligase binding	GO:0030262,apoptotic nuclear changes;GO:0007420,brain development;GO:0008283,cell population proliferation;GO:0060318,definitive erythrocyte differentiation;GO:0030968,endoplasmic reticulum unfolded protein response;GO:0001889,liver development;GO:0007095,mitotic G2 DNA damage checkpoint;GO:0044818,mitotic G2/M transition checkpoint;GO:1903363,negative regulation of cellular protein catabolic process;GO:0043407,negative regulation of MAP kinase activity;GO:0032088,negative regulation of NF-kappaB transcription factor activity;GO:0044387,negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0001933,negative regulation of protein phosphorylation;GO:0071901,negative regulation of protein serine/threonine kinase activity;GO:1900182,positive regulation of protein localization to nucleus;GO:0031398,positive regulation of protein ubiquitination;GO:1901798,positive regulation of signal transduction by p53 class mediator;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0071569,protein ufmylation;GO:0000079,regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0007346,regulation of mitotic cell cycle;GO:0045664,regulation of neuron differentiation;GO:0010921,regulation of phosphatase activity;GO:0034976,response to endoplasmic reticulum stress;GO:0016032,viral process	
RAI3_HUMAN	Q8NFJ5	GPRC5A	Retinoic acid-induced protein 3	0.082182403	0.396748742	1.406766331	3.78732544	0.2394655725	2.5970458855	0.2394655725	2.5970458855	0.0922069085636878	0.000421	-1	10.8451743538207	0.000427	1	GO:0030659,cytoplasmic vesicle membrane;GO:0070062,extracellular exosome;GO:0005887,integral component of plasma membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005730,nucleolus;GO:0005886,plasma membrane;GO:0043235,receptor complex;GO:0031982,vesicle;GO:0016021,integral component of membrane	GO:0045296,cadherin binding;GO:0004930,G protein-coupled receptor activity;GO:0030295,protein kinase activator activity	GO:0007175,negative regulation of epidermal growth factor-activated receptor activity;GO:0007165,signal transduction	
ITA5_HUMAN	P08648	ITGA5	Integrin alpha-5	0.369472312	1.060850727	26.86633978	0.752632671	0.7151615195	13.8094862255	0.7151615195	13.8094862255	0.0517876992541123	0.000012	-1	19.3096046822469	0.000012	1	GO:0071062,alphav-beta3 integrin-vitronectin complex;GO:0009986,cell surface;GO:0031410,cytoplasmic vesicle;GO:0005783,endoplasmic reticulum;GO:0009897,external side of plasma membrane;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0034674,integrin alpha5-beta1 complex;GO:0008305,integrin complex;GO:0005886,plasma membrane;GO:0001726,ruffle;GO:0045202,synapse;GO:0016021,integral component of membrane	GO:0005154,epidermal growth factor receptor binding;GO:0005178,integrin binding;GO:0046872,metal ion binding;GO:0005161,platelet-derived growth factor receptor binding;GO:0043184,vascular endothelial growth factor receptor 2 binding;GO:0001618,virus receptor activity	GO:0001525,angiogenesis;GO:0023035,CD40 signaling pathway;GO:0007155,cell adhesion;GO:0033627,cell adhesion mediated by integrin;GO:0033631,cell-cell adhesion mediated by integrin;GO:0031589,cell-substrate adhesion;GO:0007044,cell-substrate junction assembly;GO:0035987,endodermal cell differentiation;GO:0030198,extracellular matrix organization;GO:0007565,female pregnancy;GO:0007157,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0034113,heterotypic cell-cell adhesion;GO:0007229,integrin-mediated signaling pathway;GO:0007159,leukocyte cell-cell adhesion;GO:0050900,leukocyte migration;GO:0007613,memory;GO:2000811,negative regulation of anoikis;GO:0030335,positive regulation of cell migration;GO:0010811,positive regulation of cell-substrate adhesion;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:1903672,positive regulation of sprouting angiogenesis;GO:0030949,positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0035313,wound healing, spreading of epidermal cells	hsa:3678,path:hsa04151,PI3K-Akt signaling pathway;hsa:3678,path:hsa04512,ECM-receptor interaction;hsa:3678,path:hsa04145,Phagosome;hsa:3678,path:hsa04510,Focal adhesion;hsa:3678,path:hsa04810,Regulation of actin cytoskeleton;hsa:3678,path:hsa04640,Hematopoietic cell lineage;hsa:3678,path:hsa05206,MicroRNAs in cancer;hsa:3678,path:hsa05205,Proteoglycans in cancer;hsa:3678,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:3678,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:3678,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:3678,path:hsa05131,Shigellosis;hsa:3678,path:hsa05135,Yersinia infection;hsa:3678,path:hsa05133,Pertussis;hsa:3678,path:hsa05100,Bacterial invasion of epithelial cells;hsa:3678,path:hsa05168,Herpes simplex virus 1 infection;hsa:3678,path:hsa05165,Human papillomavirus infection
NAA25_HUMAN	Q14CX7	NAA25	N-alpha-acetyltransferase 25, NatB auxiliary subunit	1.008662963	0.622673645	1.031085832	2.316769776	0.815668304	1.673927804	0.815668304	1.673927804	0.487278066623237	0.213500	0	2.05221631855882	0.213832	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0031416,NatB complex		GO:0017196,N-terminal peptidyl-methionine acetylation	
HNRH2_HUMAN	P55795	HNRNPH2	Heterogeneous nuclear ribonucleoprotein H2	0.471768782	0.576865135	1.000833585	0.676027689	0.5243169585	0.838430637	0.5243169585	0.838430637	0.625355199776651	0.339778	0	1.59909120505779	0.340035	0	GO:0005829,cytosol;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0014069,postsynaptic density;GO:1990904,ribonucleoprotein complex	GO:0003723,RNA binding	GO:0000398,mRNA splicing, via spliceosome;GO:0043484,regulation of RNA splicing;GO:0016070,RNA metabolic process	
SYMPK_HUMAN	Q92797	SYMPK	Symplekin	1.055393948	1.019398334	1.823518707	0.846837546	1.037396141	1.3351781265	1.037396141	1.3351781265	0.776972091146672	0.467595	0	1.28704751611371	0.467723	0	GO:0005923,bicellular tight junction;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005847,mRNA cleavage and polyadenylation specificity factor complex;GO:0016604,nuclear body;GO:0097165,nuclear stress granule;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0005634,nucleus		GO:0007155,cell adhesion;GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0006378,mRNA polyadenylation;GO:0000398,mRNA splicing, via spliceosome;GO:0032091,negative regulation of protein binding;GO:0035307,positive regulation of protein dephosphorylation;GO:0006369,termination of RNA polymerase II transcription;GO:0006397,mRNA processing	hsa:8189,path:hsa03015,mRNA surveillance pathway;hsa:8189,path:hsa04530,Tight junction
UFC1_HUMAN	Q9Y3C8	UFC1	Ubiquitin-fold modifier-conjugating enzyme 1	0.868426965	3.289979846	0.088662851	0.013056334	2.0792034055	0.0508595925	2.0792034055	0.0508595925	40.8812438971075	0.000491	1	0.0244610952278473	0.000478	-1	GO:0070062,extracellular exosome	GO:0061657,UFM1 conjugating enzyme activity;GO:0071568,UFM1 transferase activity	GO:0007420,brain development;GO:1990592,protein K69-linked ufmylation;GO:0071569,protein ufmylation;GO:0034976,response to endoplasmic reticulum stress;GO:0061709,reticulophagy	
OSTC_HUMAN	Q9NRP0	OSTC	Oligosaccharyltransferase complex subunit OSTC	2.147267294	3.641280135	0.26541389	0.101687316	2.8942737145	0.183550603	2.8942737145	0.183550603	15.7682604534947	0.006343	1	0.063418536429513	0.006242	-1	GO:0016021,integral component of membrane;GO:0008250,oligosaccharyltransferase complex		GO:0018279,protein N-linked glycosylation via asparagine;GO:0006486,protein glycosylation	
GET3_HUMAN	O43681	GET3	ATPase GET3	4.410615796	4.428312329	8.35776767	3.574741672	4.4194640625	5.966254671	4.4194640625	5.966254671	0.740743448981747	0.438691	0	1.34999506424881	0.438851	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0043529,GET complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm	GO:0015105,arsenite transmembrane transporter activity;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0046872,metal ion binding	GO:0006620,posttranslational protein targeting to endoplasmic reticulum membrane;GO:0071816,tail-anchored membrane protein insertion into ER membrane	
TM256_HUMAN	Q8N2U0	TMEM256	Transmembrane protein 256	0.107402371	0.086040035	0.25230407	2.55E-05	0.096721203	0.126164785	0.096721203	0.126164785	0.766625988384952	0.459457	0	1.30441703666568	0.459593	0	GO:0070062,extracellular exosome;GO:0016021,integral component of membrane			
SRRT_HUMAN	Q9BXP5	SRRT	Serrate RNA effector molecule homolog	0.872392059	0.544580706	0.907213598	0.963492217	0.7084863825	0.9353529075	0.7084863825	0.9353529075	0.757453552364138	0.452163	0	1.32021296471425	0.452308	0	GO:0005737,cytoplasm;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0032991,protein-containing complex;GO:1990904,ribonucleoprotein complex;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0140262,mRNA cap binding complex binding;GO:0030674,protein-macromolecule adaptor activity;GO:0003723,RNA binding;GO:0003676,nucleic acid binding	GO:0000398,mRNA splicing, via spliceosome;GO:0097150,neuronal stem cell population maintenance;GO:0050769,positive regulation of neurogenesis;GO:0031053,primary miRNA processing;GO:0006355,regulation of transcription, DNA-templated;GO:0046685,response to arsenic-containing substance;GO:0042795,snRNA transcription by RNA polymerase II;GO:0031047,gene silencing by RNA;GO:0006397,mRNA processing	
KPRB_HUMAN	O60256	PRPSAP2	Phosphoribosyl pyrophosphate synthase-associated protein 2	2.445955319	0.872653037	3.092777199	6.737036741	1.659304178	4.91490697	1.659304178	4.91490697	0.337606426353173	0.087690	0	2.96202892463277	0.087974	0	GO:0005737,cytoplasm;GO:0002189,ribose phosphate diphosphokinase complex	GO:0004857,enzyme inhibitor activity;GO:0042802,identical protein binding;GO:0000287,magnesium ion binding;GO:0004749,ribose phosphate diphosphokinase activity	GO:0006015,5-phosphoribose 1-diphosphate biosynthetic process;GO:0006139,nucleobase-containing compound metabolic process;GO:0009116,nucleoside metabolic process;GO:0006164,purine nucleotide biosynthetic process;GO:0009165,nucleotide biosynthetic process	
LNP_HUMAN	Q9C0E8	LNPK	Endoplasmic reticulum junction formation protein lunapark	0.39891985	0.516298497	0.560024552	0.82077641	0.4576091735	0.690400481	0.4576091735	0.690400481	0.662816996936594	0.372909	0	1.5087120647506	0.373136	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0071782,endoplasmic reticulum tubular network;GO:0098826,endoplasmic reticulum tubular network membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0005654,nucleoplasm	GO:0042802,identical protein binding;GO:0046872,metal ion binding	GO:0007596,blood coagulation;GO:0042733,embryonic digit morphogenesis;GO:0035115,embryonic forelimb morphogenesis;GO:0007029,endoplasmic reticulum organization;GO:0071788,endoplasmic reticulum tubular network maintenance;GO:0071786,endoplasmic reticulum tubular network organization;GO:0060173,limb development;GO:1903373,positive regulation of endoplasmic reticulum tubular network organization;GO:0032330,regulation of chondrocyte differentiation	
DEF1_HUMAN	P59665	DEFA1	Neutrophil defensin 1	17.3386312	41.59878651	9.911148472	33.01737003	29.468708855	21.464259251	29.468708855	21.464259251	1.37291990887722	0.331786	0	0.728374607676716	0.331388	0	GO:0035578,azurophil granule lumen;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005796,Golgi lumen		GO:0019731,antibacterial humoral response;GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0019730,antimicrobial humoral response;GO:0071222,cellular response to lipopolysaccharide;GO:0006935,chemotaxis;GO:0050832,defense response to fungus;GO:0050829,defense response to Gram-negative bacterium;GO:0050830,defense response to Gram-positive bacterium;GO:0042832,defense response to protozoan;GO:0051607,defense response to virus;GO:0006955,immune response;GO:0002227,innate immune response in mucosa;GO:0030520,intracellular estrogen receptor signaling pathway;GO:0051873,killing by host of symbiont cells;GO:0031640,killing of cells of other organism;GO:0051673,membrane disruption in other organism;GO:0043312,neutrophil degranulation;GO:0044657,pore formation in membrane of other organism during symbiotic interaction;GO:0010818,T cell chemotaxis	hsa:1667,path:hsa04621,NOD-like receptor signaling pathway;hsa:1667,path:hsa05150,Staphylococcus aureus infection;hsa:728358,path:hsa04621,NOD-like receptor signaling pathway;hsa:728358,path:hsa05150,Staphylococcus aureus infection
CPSF6_HUMAN	Q16630	CPSF6	Cleavage and polyadenylation specificity factor subunit 6	0.89554276	0.384632372	1.332653221	1.497076675	0.640087566	1.414864948	0.640087566	1.414864948	0.452401882529356	0.181985	0	2.21042404688736	0.182321	0	GO:0005737,cytoplasm;GO:0035061,interchromatin granule;GO:0016020,membrane;GO:0005847,mRNA cleavage and polyadenylation specificity factor complex;GO:0005849,mRNA cleavage factor complex;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0042382,paraspeckles;GO:0005726,perichromatin fibrils;GO:1990904,ribonucleoprotein complex	GO:1990448,exon-exon junction complex binding;GO:0003729,mRNA binding;GO:0043023,ribosomal large subunit binding;GO:0003723,RNA binding;GO:0003676,nucleic acid binding	GO:1990120,messenger ribonucleoprotein complex assembly;GO:0110104,mRNA alternative polyadenylation;GO:0006397,mRNA processing;GO:0046833,positive regulation of RNA export from nucleus;GO:0098789,pre-mRNA cleavage required for polyadenylation;GO:0051290,protein heterotetramerization;GO:0051262,protein tetramerization	hsa:11052,path:hsa03015,mRNA surveillance pathway
KVD20_HUMAN	A0A0C4DH25	IGKV3D-20	Immunoglobulin kappa variable 3D-20	0.407384946	0.241294427	0.404486878	1.973088106	0.3243396865	1.188787492	0.3243396865	1.188787492	0.272832351183587	0.046414	-1	3.66525448929297	0.046624	1	GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0005576,extracellular region		GO:0002250,adaptive immune response;GO:0006955,immune response;GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response	
SR140_HUMAN	O15042	U2SURP	U2 snRNP-associated SURP motif-containing protein	0.204331085	0.1529978	0.48809517	0.249758764	0.1786644425	0.368926967	0.1786644425	0.368926967	0.484281330673233	0.210767	0	2.06491544617223	0.211100	0	GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005686,U2 snRNP	GO:0003723,RNA binding	GO:0000398,mRNA splicing, via spliceosome;GO:0006396,RNA processing	hsa:23350,path:hsa03040,Spliceosome
SPTN2_HUMAN	O15020	SPTBN2	Spectrin beta chain, non-erythrocytic 2	0.04381678	0.008314933	0.01103553	0.662724606	0.0260658565	0.336880068	0.0260658565	0.336880068	0.0773742912566736	0.000155	-1	12.9241894660166	0.000158	1	GO:0016324,apical plasma membrane;GO:0005829,cytosol;GO:0005615,extracellular space;GO:0098978,glutamatergic synapse;GO:0043025,neuronal cell body;GO:0098688,parallel fiber to Purkinje cell synapse;GO:0099189,postsynaptic spectrin-associated cytoskeleton;GO:0098793,presynapse;GO:0008091,spectrin	GO:0003779,actin binding;GO:0045296,cadherin binding;GO:0005543,phospholipid binding;GO:0005200,structural constituent of cytoskeleton;GO:0098918,structural constituent of synapse	GO:0051693,actin filament capping;GO:0030534,adult behavior;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0007411,axon guidance;GO:0021692,cerebellar Purkinje cell layer morphogenesis;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0000165,MAPK cascade;GO:0035264,multicellular organism growth;GO:0099173,postsynapse organization;GO:0007416,synapse assembly;GO:0016192,vesicle-mediated transport	hsa:6712,path:hsa05017,Spinocerebellar ataxia
FMR1_HUMAN	Q06787	FMR1	Synaptic functional regulator FMR1	2.692281361	1.994147871	0.533590486	0.80810243	2.343214616	0.670846458	2.343214616	0.670846458	3.49292239387511	0.110844	0	0.286293220185342	0.110306	0	GO:0030424,axon;GO:0043679,axon terminus;GO:0015030,Cajal body;GO:0042995,cell projection;GO:0010369,chromocenter;GO:0005694,chromosome;GO:0000775,chromosome, centromeric region;GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0030425,dendrite;GO:1902737,dendritic filopodium;GO:0043197,dendritic spine;GO:0044326,dendritic spine neck;GO:0019897,extrinsic component of plasma membrane;GO:0032433,filopodium tip;GO:0097386,glial cell projection;GO:0030426,growth cone;GO:1990812,growth cone filopodium;GO:0016020,membrane;GO:1990124,messenger ribonucleoprotein complex;GO:0005845,mRNA cap binding complex;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0071598,neuronal ribonucleoprotein granule;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0043204,perikaryon;GO:0048471,perinuclear region of cytoplasm;GO:0005844,polysome;GO:0098794,postsynapse;GO:0014069,postsynaptic density;GO:0045211,postsynaptic membrane;GO:0098793,presynapse;GO:0042734,presynaptic membrane;GO:1990904,ribonucleoprotein complex;GO:0045202,synapse;GO:0005886,plasma membrane	GO:0003682,chromatin binding;GO:0070840,dynein complex binding;GO:0002151,G-quadruplex RNA binding;GO:0042802,identical protein binding;GO:0044325,ion channel binding;GO:0035064,methylated histone binding;GO:0008017,microtubule binding;GO:0035198,miRNA binding;GO:0003730,mRNA 3'-UTR binding;GO:0048027,mRNA 5'-UTR binding;GO:0003729,mRNA binding;GO:0034046,poly(G) binding;GO:0008266,poly(U) RNA binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0043022,ribosome binding;GO:0003723,RNA binding;GO:0035613,RNA stem-loop binding;GO:0033592,RNA strand annealing activity;GO:1990825,sequence-specific mRNA binding;GO:0035197,siRNA binding;GO:0031369,translation initiation factor binding;GO:0045182,translation regulator activity;GO:0030371,translation repressor activity	GO:0006974,cellular response to DNA damage stimulus;GO:0072711,cellular response to hydroxyurea;GO:0034644,cellular response to UV;GO:0098586,cellular response to virus;GO:0031047,gene silencing by RNA;GO:0007215,glutamate receptor signaling pathway;GO:0044830,modulation by host of viral RNA genome replication;GO:0006397,mRNA processing;GO:0051028,mRNA transport;GO:2000766,negative regulation of cytoplasmic translation;GO:1900453,negative regulation of long-term synaptic depression;GO:1902373,negative regulation of mRNA catabolic process;GO:2000301,negative regulation of synaptic vesicle exocytosis;GO:0017148,negative regulation of translation;GO:0045947,negative regulation of translational initiation;GO:1901386,negative regulation of voltage-gated calcium channel activity;GO:0007399,nervous system development;GO:0060999,positive regulation of dendritic spine development;GO:0051491,positive regulation of filopodium assembly;GO:2000637,positive regulation of gene silencing by miRNA;GO:0033129,positive regulation of histone phosphorylation;GO:1901254,positive regulation of intracellular transport of viral material;GO:1902416,positive regulation of mRNA binding;GO:1901800,positive regulation of proteasomal protein catabolic process;GO:0001934,positive regulation of protein phosphorylation;GO:0002092,positive regulation of receptor internalization;GO:2001022,positive regulation of response to DNA damage stimulus;GO:0045727,positive regulation of translation;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0060998,regulation of dendritic spine development;GO:0051489,regulation of filopodium assembly;GO:0060964,regulation of gene silencing by miRNA;GO:0043488,regulation of mRNA stability;GO:0098908,regulation of neuronal action potential;GO:0046928,regulation of neurotransmitter secretion;GO:0008380,RNA splicing;GO:0016032,viral process;GO:0006417,regulation of translation	hsa:2332,path:hsa03013,RNA transport
RECQ1_HUMAN	P46063	RECQL	ATP-dependent DNA helicase Q1	2.660402604	4.040119177	3.431423961	3.870014997	3.3502608905	3.650719479	3.3502608905	3.650719479	0.917698801502464	0.461975	0	1.08968214665072	0.461841	0	GO:0005694,chromosome;GO:0005737,cytoplasm;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0043138,3'-5' DNA helicase activity;GO:0036310,annealing helicase activity;GO:0005524,ATP binding;GO:0003677,DNA binding;GO:0003678,DNA helicase activity;GO:0009378,four-way junction helicase activity;GO:0003676,nucleic acid binding	GO:0032508,DNA duplex unwinding;GO:0006310,DNA recombination;GO:0006281,DNA repair;GO:0006268,DNA unwinding involved in DNA replication;GO:0000724,double-strand break repair via homologous recombination	
HEMO_HUMAN	P02790	HPX	Hemopexin	12.12437275	14.48140202	20.79822091	60.9974316	13.302887385	40.897826255	13.302887385	40.897826255	0.325271257744992	0.078975	0	3.07435709792713	0.079247	0	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0071682,endocytic vesicle lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0015232,heme transmembrane transporter activity;GO:0046872,metal ion binding	GO:0006879,cellular iron ion homeostasis;GO:0042168,heme metabolic process;GO:0015886,heme transport;GO:0020027,hemoglobin metabolic process;GO:0002925,positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0002639,positive regulation of immunoglobulin production;GO:0060335,positive regulation of interferon-gamma-mediated signaling pathway;GO:0042531,positive regulation of tyrosine phosphorylation of STAT protein;GO:0006898,receptor-mediated endocytosis;GO:0016032,viral process	
FAAA_HUMAN	P16930	FAH	Fumarylacetoacetase	0.410483853	1.017828421	1.339566768	1.250256217	0.714156137	1.2949114925	0.714156137	1.2949114925	0.551509613696629	0.272555	0	1.81320501975887	0.272861	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0004334,fumarylacetoacetase activity;GO:0046872,metal ion binding	GO:0006527,arginine catabolic process;GO:1902000,homogentisate catabolic process;GO:0006559,L-phenylalanine catabolic process;GO:0006572,tyrosine catabolic process;GO:0009072,aromatic amino acid family metabolic process	hsa:2184,path:hsa00350,Tyrosine metabolism
TCEA1_HUMAN	P23193	TCEA1	Transcription elongation factor A protein 1	0.285458058	0.055935253	0.271525969	0.061166034	0.1706966555	0.1663460015	0.1706966555	0.1663460015	1.02615424453109	0.424807	0	0.974512365299389	0.424592	0	GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005669,transcription factor TFIID complex;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0008270,zinc ion binding;GO:0003676,nucleic acid binding;GO:0003746,translation elongation factor activity	GO:1901919,positive regulation of exoribonuclease activity;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0006355,regulation of transcription, DNA-templated;GO:0006351,transcription, DNA-templated	
CHD5_HUMAN	Q8TDI0	CHD5	Chromodomain-helicase-DNA-binding protein 5	0.242016356	0.252594433	0.326200189	0.372558803	0.2473053945	0.349379496	0.2473053945	0.349379496	0.707841751823925	0.411487	0	1.41274514737688	0.411676	0	GO:0005829,cytosol;GO:0000792,heterochromatin;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016581,NuRD complex	GO:0005524,ATP binding;GO:0003677,DNA binding;GO:0003678,DNA helicase activity;GO:0061628,H3K27me3 modified histone binding;GO:0016787,hydrolase activity;GO:0046872,metal ion binding;GO:0070615,nucleosome-dependent ATPase activity	GO:0021895,cerebral cortex neuron differentiation;GO:0098532,histone H3-K27 trimethylation;GO:0043967,histone H4 acetylation;GO:0008285,negative regulation of cell population proliferation;GO:1901798,positive regulation of signal transduction by p53 class mediator;GO:0006357,regulation of transcription by RNA polymerase II;GO:0035093,spermatogenesis, exchange of chromosomal proteins;GO:0006325,chromatin organization	
TCPG_HUMAN	P49368	CCT3	T-complex protein 1 subunit gamma	17.04859534	9.84916563	14.47988408	12.18257129	13.448880485	13.331227685	13.448880485	13.331227685	1.00882535373185	0.430440	0	0.991251851770768	0.430237	0	GO:0044297,cell body;GO:0005832,chaperonin-containing T-complex;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005874,microtubule;GO:0002199,zona pellucida receptor complex;GO:0005737,cytoplasm	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0044183,protein folding chaperone;GO:0003723,RNA binding;GO:0051082,unfolded protein binding	GO:0007339,binding of sperm to zona pellucida;GO:0046931,pore complex assembly;GO:1904851,positive regulation of establishment of protein localization to telomere;GO:1904871,positive regulation of protein localization to Cajal body;GO:1904874,positive regulation of telomerase RNA localization to Cajal body;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:0006457,protein folding;GO:0050821,protein stabilization;GO:1901998,toxin transport	
HXK3_HUMAN	P52790	HK3	Hexokinase-3	1.567263194	3.521966732	2.09362465	2.705045462	2.544614963	2.399335056	2.544614963	2.399335056	1.06055007058589	0.413949	0	0.942906919470158	0.413711	0	GO:0005829,cytosol;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005739,mitochondrion;GO:0034774,secretory granule lumen	GO:0005524,ATP binding;GO:0008865,fructokinase activity;GO:0004340,glucokinase activity;GO:0005536,glucose binding;GO:0004396,hexokinase activity;GO:0019158,mannokinase activity	GO:0061621,canonical glycolysis;GO:0001678,cellular glucose homeostasis;GO:0006002,fructose 6-phosphate metabolic process;GO:0051156,glucose 6-phosphate metabolic process;GO:0006096,glycolytic process;GO:0043312,neutrophil degranulation;GO:0019318,hexose metabolic process	hsa:3101,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:3101,path:hsa00051,Fructose and mannose metabolism;hsa:3101,path:hsa00052,Galactose metabolism;hsa:3101,path:hsa00500,Starch and sucrose metabolism;hsa:3101,path:hsa00520,Amino sugar and nucleotide sugar metabolism;hsa:3101,path:hsa00524,Neomycin, kanamycin and gentamicin biosynthesis;hsa:3101,path:hsa04066,HIF-1 signaling pathway;hsa:3101,path:hsa04910,Insulin signaling pathway;hsa:3101,path:hsa04973,Carbohydrate digestion and absorption;hsa:3101,path:hsa05230,Central carbon metabolism in cancer;hsa:3101,path:hsa04930,Type II diabetes mellitus;hsa:3101,path:hsa05131,Shigellosis
S12A9_HUMAN	Q9BXP2	SLC12A9	Solute carrier family 12 member 9	0.019390516	0.037575714	0.03368371	2.55E-05	0.028483115	0.016854605	0.028483115	0.016854605	1.68993073406348	0.270902	0	0.591740229255122	0.270409	0	GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005886,plasma membrane	GO:0015377,cation;GO:0015379,potassium	GO:0006884,cell volume homeostasis;GO:0055064,chloride ion homeostasis;GO:1902476,chloride transmembrane transport;GO:0055075,potassium ion homeostasis;GO:1990573,potassium ion import across plasma membrane;GO:0055085,transmembrane transport	
CRYAB_HUMAN	P02511	CRYAB	Alpha-crystallin B chain	1.456640679	1.902687796	0.230780299	0.038493459	1.6796642375	0.134636879	1.6796642375	0.134636879	12.4755137669227	0.010865	1	0.0801570194769358	0.010716	-1	GO:0032432,actin filament bundle;GO:0030424,axon;GO:0097512,cardiac myofibril;GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0031430,M band;GO:0015630,microtubule cytoskeleton;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0043204,perikaryon;GO:0014069,postsynaptic density;GO:0032991,protein-containing complex;GO:0097060,synaptic membrane;GO:0030018,Z disc	GO:0001540,amyloid-beta binding;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0008017,microtubule binding;GO:0042803,protein homodimerization activity;GO:0044877,protein-containing complex binding;GO:0005212,structural constituent of eye lens;GO:0005198,structural molecule activity;GO:0051082,unfolded protein binding	GO:0060561,apoptotic process involved in morphogenesis;GO:0071480,cellular response to gamma radiation;GO:0002088,lens development in camera-type eye;GO:0031109,microtubule polymerization or depolymerization;GO:0010259,multicellular organism aging;GO:0006936,muscle contraction;GO:0007517,muscle organ development;GO:1905907,negative regulation of amyloid fibril formation;GO:0043066,negative regulation of apoptotic process;GO:0030308,negative regulation of cell growth;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0010629,negative regulation of gene expression;GO:0032387,negative regulation of intracellular transport;GO:0031333,negative regulation of protein-containing complex assembly;GO:2000378,negative regulation of reactive oxygen species metabolic process;GO:0045892,negative regulation of transcription, DNA-templated;GO:0006457,protein folding;GO:0050821,protein stabilization;GO:0010941,regulation of cell death;GO:1900034,regulation of cellular response to heat;GO:0032355,response to estradiol;GO:0042542,response to hydrogen peroxide;GO:0001666,response to hypoxia;GO:0051403,stress-activated MAPK cascade;GO:0007021,tubulin complex assembly	hsa:1410,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:1410,path:hsa04213,Longevity regulating pathway - multiple species
DRG2_HUMAN	P55039	DRG2	Developmentally-regulated GTP-binding protein 2	0.502234894	0.385601354	0.617408987	0.432277033	0.443918124	0.52484301	0.443918124	0.52484301	0.845811253159302	0.489348	0	1.18229687328558	0.489274	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0046872,metal ion binding;GO:0003723,RNA binding	GO:0002181,cytoplasmic translation;GO:0007165,signal transduction	
FAHD1_HUMAN	Q6P587	FAHD1	Acylpyruvase FAHD1, mitochondrial	2.051472263	2.260702958	1.91360539	1.991103434	2.1560876105	1.952354412	2.1560876105	1.952354412	1.10435256900477	0.400710	0	0.905507922077084	0.400444	0	GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0018773,acetylpyruvate hydrolase activity;GO:0047621,acylpyruvate hydrolase activity;GO:0034545,fumarylpyruvate hydrolase activity;GO:0046872,metal ion binding;GO:0008948,oxaloacetate decarboxylase activity	GO:0006099,tricarboxylic acid cycle	hsa:81889,path:hsa00350,Tyrosine metabolism
VAV_HUMAN	P15498	VAV1	Proto-oncogene vav	0.14606402	0.170929939	0.255878363	0.278546754	0.1584969795	0.2672125585	0.1584969795	0.2672125585	0.593149440242346	0.310699	0	1.68591577797229	0.310980	0	GO:0005911,cell-cell junction;GO:0005829,cytosol;GO:0005886,plasma membrane	GO:0005085,guanyl-nucleotide exchange factor activity;GO:0046872,metal ion binding;GO:0140031,phosphorylation-dependent protein binding;GO:0001784,phosphotyrosine residue binding	GO:0019221,cytokine-mediated signaling pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0007186,G protein-coupled receptor signaling pathway;GO:0006955,immune response;GO:0007229,integrin-mediated signaling pathway;GO:0030593,neutrophil chemotaxis;GO:0030168,platelet activation;GO:0043065,positive regulation of apoptotic process;GO:0043547,positive regulation of GTPase activity;GO:0045954,positive regulation of natural killer cell mediated cytotoxicity;GO:0051897,positive regulation of protein kinase B signaling;GO:0046579,positive regulation of Ras protein signal transduction;GO:0072593,reactive oxygen species metabolic process;GO:0008361,regulation of cell size;GO:0043087,regulation of GTPase activity;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007264,small GTPase mediated signal transduction;GO:0031295,T cell costimulation;GO:0030217,T cell differentiation;GO:0048010,vascular endothelial growth factor receptor signaling pathway	hsa:7409,path:hsa04015,Rap1 signaling pathway;hsa:7409,path:hsa04024,cAMP signaling pathway;hsa:7409,path:hsa04510,Focal adhesion;hsa:7409,path:hsa04810,Regulation of actin cytoskeleton;hsa:7409,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:7409,path:hsa04660,T cell receptor signaling pathway;hsa:7409,path:hsa04662,B cell receptor signaling pathway;hsa:7409,path:hsa04664,Fc epsilon RI signaling pathway;hsa:7409,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:7409,path:hsa04670,Leukocyte transendothelial migration;hsa:7409,path:hsa04062,Chemokine signaling pathway;hsa:7409,path:hsa05205,Proteoglycans in cancer;hsa:7409,path:hsa05135,Yersinia infection
IF2B_HUMAN	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	1.869817049	2.278689168	1.523037298	1.065286406	2.0742531085	1.294161852	2.0742531085	1.294161852	1.60277719923087	0.285881	0	0.623917036304155	0.285409	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005850,eukaryotic translation initiation factor 2 complex	GO:0046872,metal ion binding;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0008135,translation factor activity, RNA binding;GO:0003743,translation initiation factor activity;GO:0031369,translation initiation factor binding	GO:0001732,formation of cytoplasmic translation initiation complex;GO:0001731,formation of translation preinitiation complex;GO:0001701,in utero embryonic development;GO:0002176,male germ cell proliferation;GO:0008584,male gonad development;GO:0006413,translational initiation;GO:0055085,transmembrane transport	hsa:8894,path:hsa03013,RNA transport
ITIH4_HUMAN	Q14624	ITIH4	Inter-alpha-trypsin inhibitor heavy chain H4	2.331115035	1.990391873	2.894593163	16.24521439	2.160753454	9.5699037765	2.160753454	9.5699037765	0.225786330193411	0.024424	-1	4.42896608994614	0.024568	1	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0031089,platelet dense granule lumen;GO:0005737,cytoplasm;GO:0005615,extracellular space;GO:0005886,plasma membrane	GO:0004866,endopeptidase inhibitor activity;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0006953,acute-phase response;GO:0030212,hyaluronan metabolic process;GO:0002576,platelet degranulation;GO:0034097,response to cytokine	
MAP1A_HUMAN	P78559	MAP1A	Microtubule-associated protein 1A	0.06752475	0.03913248	0.039395286	0.125312325	0.053328615	0.0823538055	0.053328615	0.0823538055	0.647554957250883	0.359514	0	1.54427047280339	0.359753	0	GO:0030424,axon;GO:1904115,axon cytoplasm;GO:0043194,axon initial segment;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0044307,dendritic branch;GO:1901588,dendritic microtubule;GO:0043198,dendritic shaft;GO:0005874,microtubule;GO:0005875,microtubule associated complex;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0150001,primary dendrite;GO:0045202,synapse	GO:0003779,actin binding;GO:0008093,cytoskeletal anchor activity;GO:0008017,microtubule binding;GO:0005198,structural molecule activity;GO:0048156,tau protein binding;GO:0015631,tubulin binding	GO:0099641,anterograde axonal protein transport;GO:0008306,associative learning;GO:0007409,axonogenesis;GO:0016358,dendrite development;GO:0007613,memory;GO:0000226,microtubule cytoskeleton organization;GO:0032435,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1902817,negative regulation of protein localization to microtubule;GO:0070050,neuron cellular homeostasis;GO:1990535,neuron projection maintenance;GO:1903829,positive regulation of cellular protein localization;GO:2000010,positive regulation of protein localization to cell surface;GO:0031114,regulation of microtubule depolymerization;GO:0048167,regulation of synaptic plasticity;GO:0099642,retrograde axonal protein transport;GO:0050882,voluntary musculoskeletal movement	
6PGD_HUMAN	P52209	PGD	6-phosphogluconate dehydrogenase, decarboxylating	11.34618324	19.536391	17.62414779	11.6791643	15.44128712	14.651656045	15.44128712	14.651656045	1.05389363991175	0.416018	0	0.948862353969363	0.415784	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0050661,NADP binding;GO:0004616,phosphogluconate dehydrogenase (decarboxylating) activity;GO:0016491,oxidoreductase activity	GO:0046177,D-gluconate catabolic process;GO:0019322,pentose biosynthetic process;GO:0006098,pentose-phosphate shunt;GO:0009051,pentose-phosphate shunt, oxidative branch;GO:0019521,D-gluconate metabolic process	hsa:5226,path:hsa00030,Pentose phosphate pathway;hsa:5226,path:hsa00480,Glutathione metabolism
MPPB_HUMAN	O75439	PMPCB	Mitochondrial-processing peptidase subunit beta	0.519213508	0.332946949	0.676307736	0.338675539	0.4260802285	0.5074916375	0.4260802285	0.5074916375	0.839580787180951	0.491834	0	1.19107060960469	0.491765	0	GO:0005743,mitochondrial inner membrane;GO:0017087,mitochondrial processing peptidase complex;GO:0005739,mitochondrion	GO:0046872,metal ion binding;GO:0004222,metalloendopeptidase activity	GO:0006851,mitochondrial calcium ion transmembrane transport;GO:0006627,protein processing involved in protein targeting to mitochondrion	
SF3B2_HUMAN	Q13435	SF3B2	Splicing factor 3B subunit 2	2.324291792	0.614290621	2.117680999	1.267815302	1.4692912065	1.6927481505	1.4692912065	1.6927481505	0.867991618284152	0.480650	0	1.15208485765888	0.480557	0	GO:0071013,catalytic step 2 spliceosome;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0071011,precatalytic spliceosome;GO:0005681,spliceosomal complex;GO:0005689,U12-type spliceosomal complex;GO:0005686,U2 snRNP;GO:0071005,U2-type precatalytic spliceosome;GO:0005684,U2-type spliceosomal complex	GO:0003723,RNA binding	GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0008380,RNA splicing;GO:0016032,viral process	hsa:10992,path:hsa03040,Spliceosome
CHIP_HUMAN	Q9UNE7	STUB1	E3 ubiquitin-protein ligase CHIP	0.157063735	0.10204353	0.212567716	0.32005612	0.1295536325	0.266311918	0.1295536325	0.266311918	0.48647328092917	0.212766	0	2.05561135462566	0.213098	0	GO:0101031,chaperone complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0042405,nuclear inclusion body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0031371,ubiquitin conjugating enzyme complex;GO:0000151,ubiquitin ligase complex;GO:0030018,Z disc	GO:0051087,chaperone binding;GO:0019899,enzyme binding;GO:0001664,G protein-coupled receptor binding;GO:0031072,heat shock protein binding;GO:0030544,Hsp70 protein binding;GO:0051879,Hsp90 protein binding;GO:0019900,kinase binding;GO:0051787,misfolded protein binding;GO:0042803,protein homodimerization activity;GO:0030674,protein-macromolecule adaptor activity;GO:0046332,SMAD binding;GO:0048156,tau protein binding;GO:0030911,TPR domain binding;GO:0061630,ubiquitin protein ligase activity;GO:0031625,ubiquitin protein ligase binding;GO:0004842,ubiquitin-protein transferase activity;GO:0034450,ubiquitin-ubiquitin ligase activity	GO:0034605,cellular response to heat;GO:0071456,cellular response to hypoxia;GO:0071218,cellular response to misfolded protein;GO:0061684,chaperone-mediated autophagy;GO:0006281,DNA repair;GO:0030968,endoplasmic reticulum unfolded protein response;GO:0038128,ERBB2 signaling pathway;GO:0032091,negative regulation of protein binding;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0090035,positive regulation of chaperone-mediated protein complex assembly;GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0031398,positive regulation of protein ubiquitination;GO:0045862,positive regulation of proteolysis;GO:0051443,positive regulation of ubiquitin-protein transferase activity;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051865,protein autoubiquitination;GO:0070534,protein K63-linked ubiquitination;GO:0051604,protein maturation;GO:0000209,protein polyubiquitination;GO:0006515,protein quality control for misfolded or incompletely synthesized proteins;GO:0016567,protein ubiquitination;GO:0031943,regulation of glucocorticoid metabolic process;GO:0060544,regulation of necroptotic process;GO:0031647,regulation of protein stability;GO:0002931,response to ischemia;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0030579,ubiquitin-dependent SMAD protein catabolic process	hsa:10273,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:10273,path:hsa04120,Ubiquitin mediated proteolysis
LA_HUMAN	P05455	SSB	Lupus La protein	2.451801062	0.94676219	3.810224155	1.53444254	1.699281626	2.6723333475	1.699281626	2.6723333475	0.635879362726098	0.349169	0	1.57262534156301	0.349418	0	GO:0000781,chromosome, telomeric region;GO:0005737,cytoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex	GO:0003729,mRNA binding;GO:0008266,poly(U) RNA binding;GO:0003723,RNA binding;GO:1990825,sequence-specific mRNA binding;GO:0000049,tRNA binding	GO:0008334,histone mRNA metabolic process;GO:0075522,IRES-dependent viral translational initiation;GO:0071045,nuclear histone mRNA catabolic process;GO:1903608,protein localization to cytoplasmic stress granule;GO:0042780,tRNA 3'-end processing;GO:0001682,tRNA 5'-leader removal;GO:0006409,tRNA export from nucleus;GO:0006400,tRNA modification;GO:0008033,tRNA processing;GO:0006396,RNA processing	hsa:6741,path:hsa05322,Systemic lupus erythematosus
CNN2_HUMAN	Q99439	CNN2	Calponin-2	2.773626159	4.609711838	2.284669475	2.387175239	3.6916689985	2.335922357	3.6916689985	2.335922357	1.58039028456458	0.289925	0	0.632755092059752	0.289459	0	GO:0005911,cell-cell junction;GO:0005856,cytoskeleton;GO:0005576,extracellular region;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0035580,specific granule lumen;GO:0001725,stress fiber;GO:1904724,tertiary granule lumen	GO:0003779,actin binding;GO:0045296,cadherin binding;GO:0005516,calmodulin binding	GO:0031032,actomyosin structure organization;GO:0071260,cellular response to mechanical stimulus;GO:0007010,cytoskeleton organization;GO:0035722,interleukin-12-mediated signaling pathway;GO:0043312,neutrophil degranulation;GO:0032970,regulation of actin filament-based process;GO:0030097,hemopoiesis;GO:0030336,negative regulation of cell migration;GO:0050765,negative regulation of phagocytosis;GO:0010628,positive regulation of gene expression;GO:0042127,regulation of cell population proliferation;GO:0042060,wound healing	
CAV1_HUMAN	Q03135	CAV1	Caveolin-1	1.985457977	3.069824157	1.207028788	8.805030363	2.527641067	5.0060295755	2.527641067	5.0060295755	0.504919323563433	0.229654	0	1.98051441751639	0.229981	0	GO:0002080,acrosomal membrane;GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0005901,caveola;GO:0002095,caveolar macromolecular signaling complex;GO:0005938,cell cortex;GO:0005929,cilium;GO:0031410,cytoplasmic vesicle;GO:0031901,early endosome membrane;GO:0030666,endocytic vesicle membrane;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005768,endosome;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005887,integral component of plasma membrane;GO:0005811,lipid droplet;GO:0016020,membrane;GO:0045121,membrane raft;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0016021,integral component of membrane	GO:0051117,ATPase binding;GO:0015485,cholesterol binding;GO:0019899,enzyme binding;GO:0042802,identical protein binding;GO:0070320,inward rectifier potassium channel inhibitor activity;GO:0044325,ion channel binding;GO:0060090,molecular adaptor activity;GO:0050998,nitric-oxide synthase binding;GO:0005113,patched binding;GO:0016504,peptidase activator activity;GO:0046982,protein heterodimerization activity;GO:0019901,protein kinase binding;GO:0044877,protein-containing complex binding;GO:0030674,protein-macromolecule adaptor activity;GO:0005102,signaling receptor binding;GO:0031267,small GTPase binding	GO:0001525,angiogenesis;GO:0086098,angiotensin-activated signaling pathway involved in heart process;GO:0097190,apoptotic signaling pathway;GO:0071711,basement membrane organization;GO:1904886,beta-catenin destruction complex disassembly;GO:0055074,calcium ion homeostasis;GO:0006816,calcium ion transport;GO:0070836,caveola assembly;GO:0072584,caveolin-mediated endocytosis;GO:0030154,cell differentiation;GO:0006874,cellular calcium ion homeostasis;GO:0071360,cellular response to exogenous dsRNA;GO:0071455,cellular response to hyperoxia;GO:0071375,cellular response to peptide hormone stimulus;GO:0009267,cellular response to starvation;GO:0071560,cellular response to transforming growth factor beta stimulus;GO:0042632,cholesterol homeostasis;GO:0030301,cholesterol transport;GO:0000188,inactivation of MAPK activity;GO:0038016,insulin receptor internalization;GO:0007595,lactation;GO:0050900,leukocyte migration;GO:0019915,lipid storage;GO:0032507,maintenance of protein location in cell;GO:0030879,mammary gland development;GO:0060056,mammary gland involution;GO:0051899,membrane depolarization;GO:2000811,negative regulation of anoikis;GO:0030514,negative regulation of BMP signaling pathway;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0001960,negative regulation of cytokine-mediated signaling pathway;GO:0001937,negative regulation of endothelial cell proliferation;GO:0030857,negative regulation of epithelial cell differentiation;GO:1903609,negative regulation of inward rectifier potassium channel activity;GO:0043409,negative regulation of MAPK cascade;GO:0060546,negative regulation of necroptotic process;GO:0045019,negative regulation of nitric oxide biosynthetic process;GO:0051001,negative regulation of nitric-oxide synthase activity;GO:0033137,negative regulation of peptidyl-serine phosphorylation;GO:1900085,negative regulation of peptidyl-tyrosine autophosphorylation;GO:0048550,negative regulation of pinocytosis;GO:1901380,negative regulation of potassium ion transmembrane transport;GO:0032091,negative regulation of protein binding;GO:0061099,negative regulation of protein tyrosine kinase activity;GO:0031397,negative regulation of protein ubiquitination;GO:0046426,negative regulation of receptor signaling pathway via JAK-STAT;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0042532,negative regulation of tyrosine phosphorylation of STAT protein;GO:0033484,nitric oxide homeostasis;GO:0010524,positive regulation of calcium ion transport into cytosol;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043085,positive regulation of catalytic activity;GO:0060355,positive regulation of cell adhesion molecule production;GO:0030335,positive regulation of cell migration;GO:0010875,positive regulation of cholesterol efflux;GO:0120162,positive regulation of cold-induced thermogenesis;GO:1903071,positive regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:2001238,positive regulation of extrinsic apoptotic signaling pathway;GO:1903598,positive regulation of gap junction assembly;GO:0010628,positive regulation of gene expression;GO:2001244,positive regulation of intrinsic apoptotic signaling pathway;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0032092,positive regulation of protein binding;GO:0031398,positive regulation of protein ubiquitination;GO:0034141,positive regulation of toll-like receptor 3 signaling pathway;GO:0045907,positive regulation of vasoconstriction;GO:0010608,posttranscriptional regulation of gene expression;GO:0008104,protein localization;GO:1903361,protein localization to basolateral plasma membrane;GO:0044860,protein localization to plasma membrane raft;GO:0015031,protein transport;GO:0031623,receptor internalization;GO:2000286,receptor internalization involved in canonical Wnt signaling pathway;GO:0019065,receptor-mediated endocytosis of virus by host cell;GO:0030193,regulation of blood coagulation;GO:0098909,regulation of cardiac muscle cell action potential involved in regulation of contraction;GO:1901844,regulation of cell communication by electrical coupling involved in cardiac conduction;GO:0051480,regulation of cytosolic calcium ion concentration;GO:2000535,regulation of entry of bacterium into host cell;GO:0019217,regulation of fatty acid metabolic process;GO:0086091,regulation of heart rate by cardiac conduction;GO:0098903,regulation of membrane repolarization during action potential;GO:0050999,regulation of nitric-oxide synthase activity;GO:0052547,regulation of peptidase activity;GO:1900027,regulation of ruffle assembly;GO:0006940,regulation of smooth muscle contraction;GO:0003057,regulation of the force of heart contraction by chemical signal;GO:0098911,regulation of ventricular cardiac muscle cell action potential;GO:0009617,response to bacterium;GO:0051592,response to calcium ion;GO:0043627,response to estrogen;GO:0001666,response to hypoxia;GO:0002931,response to ischemia;GO:0032570,response to progesterone;GO:0007519,skeletal muscle tissue development;GO:0031295,T cell costimulation;GO:0006641,triglyceride metabolic process;GO:0001570,vasculogenesis;GO:0042310,vasoconstriction;GO:0016050,vesicle organization	hsa:857,path:hsa04144,Endocytosis;hsa:857,path:hsa04510,Focal adhesion;hsa:857,path:hsa05205,Proteoglycans in cancer;hsa:857,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:857,path:hsa05416,Viral myocarditis;hsa:857,path:hsa05100,Bacterial invasion of epithelial cells
KV401_HUMAN	P06312	IGKV4-1	Immunoglobulin kappa variable 4-1	1.667894772	1.376127866	1.230927044	1.876161086	1.522011319	1.553544065	1.522011319	1.553544065	0.979702702542911	0.440160	0	1.02071781307167	0.439977	0	GO:0072562,blood microparticle;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane	GO:0003823,antigen binding	GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response	
MMP9_HUMAN	P14780	MMP9	Matrix metalloproteinase-9	0.35112616	0.604706336	0.564313966	2.567601265	0.477916248	1.5659576155	0.477916248	1.5659576155	0.305191049406152	0.065601	0	3.2766360676233	0.065851	0	GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:1904724,tertiary granule lumen	GO:0005518,collagen binding;GO:0004175,endopeptidase activity;GO:0042802,identical protein binding;GO:0004222,metalloendopeptidase activity;GO:0008237,metallopeptidase activity;GO:0008233,peptidase activity;GO:0004252,serine-type endopeptidase activity;GO:0008270,zinc ion binding	GO:0071276,cellular response to cadmium ion;GO:0034614,cellular response to reactive oxygen species;GO:0071492,cellular response to UV-A;GO:0030574,collagen catabolic process;GO:0019221,cytokine-mediated signaling pathway;GO:0007566,embryo implantation;GO:0035987,endodermal cell differentiation;GO:0048013,ephrin receptor signaling pathway;GO:0022617,extracellular matrix disassembly;GO:0030198,extracellular matrix organization;GO:0050900,leukocyte migration;GO:0030225,macrophage differentiation;GO:0043066,negative regulation of apoptotic process;GO:2001258,negative regulation of cation channel activity;GO:2001268,negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:2000697,negative regulation of epithelial cell differentiation involved in kidney development;GO:2001243,negative regulation of intrinsic apoptotic signaling pathway;GO:0043312,neutrophil degranulation;GO:0001503,ossification;GO:0043065,positive regulation of apoptotic process;GO:0030335,positive regulation of cell migration;GO:0043388,positive regulation of DNA binding;GO:0045742,positive regulation of epidermal growth factor receptor signaling pathway;GO:0051549,positive regulation of keratinocyte migration;GO:0001934,positive regulation of protein phosphorylation;GO:1900122,positive regulation of receptor binding;GO:0090200,positive regulation of release of cytochrome c from mitochondria;GO:1904707,positive regulation of vascular associated smooth muscle cell proliferation;GO:0006508,proteolysis;GO:0150077,regulation of neuroinflammatory response;GO:1904645,response to amyloid-beta;GO:0001501,skeletal system development	hsa:4318,path:hsa04668,TNF signaling pathway;hsa:4318,path:hsa04657,IL-17 signaling pathway;hsa:4318,path:hsa04670,Leukocyte transendothelial migration;hsa:4318,path:hsa04915,Estrogen signaling pathway;hsa:4318,path:hsa04926,Relaxin signaling pathway;hsa:4318,path:hsa05200,Pathways in cancer;hsa:4318,path:hsa05202,Transcriptional misregulation in cancer;hsa:4318,path:hsa05206,MicroRNAs in cancer;hsa:4318,path:hsa05205,Proteoglycans in cancer;hsa:4318,path:hsa05219,Bladder cancer;hsa:4318,path:hsa05215,Prostate cancer;hsa:4318,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:4318,path:hsa05161,Hepatitis B;hsa:4318,path:hsa01522,Endocrine resistance
NMI_HUMAN	Q13287	NMI	N-myc-interactor	0.332418779	0.276650064	0.57366798	0.246736241	0.3045344215	0.4102021105	0.3045344215	0.4102021105	0.742400913366339	0.440038	0	1.34698110144505	0.440196	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005615,extracellular space;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0042802,identical protein binding;GO:0003712,transcription coregulator activity	GO:0060333,interferon-gamma-mediated signaling pathway;GO:0002281,macrophage activation involved in immune response;GO:0008285,negative regulation of cell population proliferation;GO:0045824,negative regulation of innate immune response;GO:0032687,negative regulation of interferon-alpha production;GO:0032688,negative regulation of interferon-beta production;GO:1901223,negative regulation of NIK/NF-kappaB signaling;GO:0050729,positive regulation of inflammatory response;GO:0045089,positive regulation of innate immune response;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:1902524,positive regulation of protein K48-linked ubiquitination;GO:0007259,receptor signaling pathway via JAK-STAT;GO:0009615,response to virus;GO:0034142,toll-like receptor 4 signaling pathway;GO:0006366,transcription by RNA polymerase II	
TX1B3_HUMAN	O14907	TAX1BP3	Tax1-binding protein 3	0.165175518	0.551388896	0.146171237	0.307409189	0.358282207	0.226790213	0.358282207	0.226790213	1.57979571631691	0.290034	0	0.632993234297008	0.289568	0	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0001650,fibrillar center;GO:0043231,intracellular membrane-bounded organelle;GO:0005886,plasma membrane	GO:0008013,beta-catenin binding;GO:0008022,protein C-terminus binding	GO:0090630,activation of GTPase activity;GO:0008285,negative regulation of cell population proliferation;GO:2000009,negative regulation of protein localization to cell surface;GO:0030178,negative regulation of Wnt signaling pathway;GO:0007266,Rho protein signal transduction;GO:0016055,Wnt signaling pathway	
E2AK2_HUMAN	P19525	EIF2AK2	Interferon-induced, double-stranded RNA-activated protein kinase	1.611021559	1.007000421	2.166998868	1.129668974	1.30901099	1.648333921	1.30901099	1.648333921	0.794141874606244	0.480893	0	1.2592208419885	0.481005	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005840,ribosome	GO:0005524,ATP binding;GO:0003725,double-stranded RNA binding;GO:0004694,eukaryotic translation initiation factor 2alpha kinase activity;GO:0042802,identical protein binding;GO:0004715,non-membrane spanning protein tyrosine kinase activity;GO:0004672,protein kinase activity;GO:0019888,protein phosphatase regulator activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0003723,RNA binding;GO:0004714,transmembrane receptor protein tyrosine kinase activity	GO:0000186,activation of MAPKK activity;GO:0034198,cellular response to amino acid starvation;GO:0051607,defense response to virus;GO:0045087,innate immune response;GO:0030683,mitigation of host immune response by virus;GO:0008285,negative regulation of cell population proliferation;GO:0033689,negative regulation of osteoblast proliferation;GO:0017148,negative regulation of translation;GO:0045071,negative regulation of viral genome replication;GO:0032722,positive regulation of chemokine production;GO:0001819,positive regulation of cytokine production;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:0032874,positive regulation of stress-activated MAPK cascade;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:1901532,regulation of hematopoietic progenitor cell differentiation;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1902033,regulation of hematopoietic stem cell proliferation;GO:1900225,regulation of NLRP3 inflammasome complex assembly;GO:0035455,response to interferon-alpha;GO:0009615,response to virus	hsa:5610,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:5610,path:hsa04217,Necroptosis;hsa:5610,path:hsa05203,Viral carcinogenesis;hsa:5610,path:hsa05162,Measles;hsa:5610,path:hsa05164,Influenza A;hsa:5610,path:hsa05160,Hepatitis C;hsa:5610,path:hsa05168,Herpes simplex virus 1 infection;hsa:5610,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:5610,path:hsa05169,Epstein-Barr virus infection;hsa:5610,path:hsa05165,Human papillomavirus infection
EXOC8_HUMAN	Q8IYI6	EXOC8	Exocyst complex component 8	0.176468082	0.215185221	0.244034563	0.697053513	0.1958266515	0.470544038	0.1958266515	0.470544038	0.416170720879477	0.150242	0	2.40286005196795	0.150573	0	GO:0031252,cell leading edge;GO:0005829,cytosol;GO:0000145,exocyst;GO:0030426,growth cone;GO:0005770,late endosome;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane	GO:0035091,phosphatidylinositol binding;GO:0031267,small GTPase binding	GO:0034613,cellular protein localization;GO:0060271,cilium assembly;GO:0007032,endosome organization;GO:0006887,exocytosis;GO:0022617,extracellular matrix disassembly;GO:0006893,Golgi to plasma membrane transport;GO:0008104,protein localization;GO:0015031,protein transport;GO:0016241,regulation of macroautophagy	
C163A_HUMAN	Q86VB7	CD163	Scavenger receptor cysteine-rich type 1 protein M130	0.444322513	1.205805958	1.063559572	1.383911332	0.8250642355	1.223735452	0.8250642355	1.223735452	0.67421780920996	0.382815	0	1.48320021562733	0.383033	0	GO:0005829,cytosol;GO:0030666,endocytic vesicle membrane;GO:0009897,external side of plasma membrane;GO:0005576,extracellular region;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane;GO:0016020,membrane;GO:0016021,integral component of membrane	GO:0005044,scavenger receptor activity	GO:0006953,acute-phase response;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0006898,receptor-mediated endocytosis	
TFR1_HUMAN	P02786	TFRC	Transferrin receptor protein 1	2.610868955	4.875425262	6.272143947	10.67344658	3.7431471085	8.4727952635	3.7431471085	8.4727952635	0.441784203688377	0.172554	0	2.26354856432435	0.172889	0	GO:0016323,basolateral plasma membrane;GO:0072562,blood microparticle;GO:0009986,cell surface;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0005905,clathrin-coated pit;GO:0031410,cytoplasmic vesicle;GO:0005769,early endosome;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1903561,extracellular vesicle;GO:1990712,HFE-transferrin receptor complex;GO:0005887,integral component of plasma membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0042470,melanosome;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0055037,recycling endosome;GO:0016021,integral component of membrane	GO:0003725,double-stranded RNA binding;GO:0042802,identical protein binding;GO:0008235,metalloexopeptidase activity;GO:0042803,protein homodimerization activity;GO:0019901,protein kinase binding;GO:0044877,protein-containing complex binding;GO:0003723,RNA binding;GO:0004998,transferrin receptor activity;GO:0001618,virus receptor activity	GO:0006879,cellular iron ion homeostasis;GO:0035690,cellular response to drug;GO:1990830,cellular response to leukemia inhibitory factor;GO:0035556,intracellular signal transduction;GO:0006826,iron ion transport;GO:0061024,membrane organization;GO:0043066,negative regulation of apoptotic process;GO:0010637,negative regulation of mitochondrial fusion;GO:0030316,osteoclast differentiation;GO:0030890,positive regulation of B cell proliferation;GO:0045780,positive regulation of bone resorption;GO:0010628,positive regulation of gene expression;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045830,positive regulation of isotype switching;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:1900182,positive regulation of protein localization to nucleus;GO:0001934,positive regulation of protein phosphorylation;GO:0031334,positive regulation of protein-containing complex assembly;GO:0042102,positive regulation of T cell proliferation;GO:0031623,receptor internalization;GO:0033572,transferrin transport;GO:0150104,transport across blood-brain barrier	hsa:7037,path:hsa04066,HIF-1 signaling pathway;hsa:7037,path:hsa04144,Endocytosis;hsa:7037,path:hsa04145,Phagosome;hsa:7037,path:hsa04216,Ferroptosis;hsa:7037,path:hsa04640,Hematopoietic cell lineage
NEP_HUMAN	P08473	MME	Neprilysin	0.266095774	0.493055613	0.30267783	1.304515063	0.3795756935	0.8035964465	0.3795756935	0.8035964465	0.472346157269873	0.199923	0	2.11709142671961	0.200257	0	GO:0030424,axon;GO:0005903,brush border;GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0030425,dendrite;GO:0005769,early endosome;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0045121,membrane raft;GO:0044306,neuron projection terminus;GO:0043025,neuronal cell body;GO:0005886,plasma membrane;GO:0098793,presynapse;GO:0030667,secretory granule membrane;GO:0045202,synapse;GO:0008021,synaptic vesicle;GO:0005802,trans-Golgi network	GO:1901612,cardiolipin binding;GO:0004175,endopeptidase activity;GO:0008238,exopeptidase activity;GO:0004222,metalloendopeptidase activity;GO:0008237,metallopeptidase activity;GO:0070012,oligopeptidase activity;GO:0042277,peptide binding;GO:0001786,phosphatidylserine binding;GO:0042803,protein homodimerization activity;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0007568,aging;GO:0097242,amyloid-beta clearance;GO:0150094,amyloid-beta clearance by cellular catabolic process;GO:0050435,amyloid-beta metabolic process;GO:0002003,angiotensin maturation;GO:0071345,cellular response to cytokine stimulus;GO:0071492,cellular response to UV-A;GO:0071493,cellular response to UV-B;GO:0046449,creatinine metabolic process;GO:0001822,kidney development;GO:0007611,learning or memory;GO:0030324,lung development;GO:0061837,neuropeptide processing;GO:0043312,neutrophil degranulation;GO:0006518,peptide metabolic process;GO:0001890,placenta development;GO:1900273,positive regulation of long-term synaptic potentiation;GO:0050769,positive regulation of neurogenesis;GO:0016485,protein processing;GO:0006508,proteolysis;GO:0090399,replicative senescence;GO:0019233,sensory perception of pain	hsa:4311,path:hsa04640,Hematopoietic cell lineage;hsa:4311,path:hsa04614,Renin-angiotensin system;hsa:4311,path:hsa04974,Protein digestion and absorption;hsa:4311,path:hsa05010,Alzheimer disease
LSM8_HUMAN	O95777	LSM8	U6 snRNA-associated Sm-like protein LSm8	0.73285071	0.439918292	0.517511418	1.487369476	0.586384501	1.002440447	0.586384501	1.002440447	0.584956944579472	0.303233	0	1.70952752893447	0.303519	0	GO:0120115,Lsm2-8 complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0071011,precatalytic spliceosome;GO:0071005,U2-type precatalytic spliceosome;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005688,U6 snRNP;GO:0005681,spliceosomal complex	GO:0003723,RNA binding;GO:0017070,U6 snRNA binding	GO:0000398,mRNA splicing, via spliceosome;GO:0016070,RNA metabolic process	hsa:51691,path:hsa03040,Spliceosome;hsa:51691,path:hsa03018,RNA degradation
UGDH_HUMAN	O60701	UGDH	UDP-glucose 6-dehydrogenase	3.374438899	6.664976087	7.334943721	3.772756371	5.019707493	5.553850046	5.019707493	5.553850046	0.903824815474681	0.467077	0	1.10640909928414	0.466954	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0042802,identical protein binding;GO:0051287,NAD binding;GO:0003979,UDP-glucose 6-dehydrogenase activity	GO:0005975,carbohydrate metabolic process;GO:0030206,chondroitin sulfate biosynthetic process;GO:0001702,gastrulation with mouth forming second;GO:0006024,glycosaminoglycan biosynthetic process;GO:0015012,heparan sulfate proteoglycan biosynthetic process;GO:0048666,neuron development;GO:0034214,protein hexamerization;GO:0006065,UDP-glucuronate biosynthetic process	hsa:7358,path:hsa00040,Pentose and glucuronate interconversions;hsa:7358,path:hsa00053,Ascorbate and aldarate metabolism;hsa:7358,path:hsa00520,Amino sugar and nucleotide sugar metabolism
SP16H_HUMAN	Q9Y5B9	SUPT16H	FACT complex subunit SPT16	1.075539415	0.4183195	1.375224561	0.791852576	0.7469294575	1.0835385685	0.7469294575	1.0835385685	0.689342750885198	0.395816	0	1.45065716396652	0.396021	0	GO:0035101,FACT complex;GO:0005654,nucleoplasm	GO:0031491,nucleosome binding;GO:0003723,RNA binding	GO:0006281,DNA repair;GO:0006260,DNA replication;GO:0034724,DNA replication-independent nucleosome organization;GO:0006337,nucleosome disassembly;GO:0032786,positive regulation of DNA-templated transcription, elongation;GO:0032968,positive regulation of transcription elongation from RNA polymerase II promoter;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter;GO:0016032,viral process	
COFA1_HUMAN	P39059	COL15A1	Collagen alpha-1(XV) chain	0.569780388	0.196570667	0.507649736	1.836614925	0.3831755275	1.1721323305	0.3831755275	1.1721323305	0.326904665564977	0.080108	0	3.05899580317013	0.080382	0	GO:0005582,collagen type XV trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0016021,integral component of membrane;GO:0005581,collagen trimer	GO:0005201,extracellular matrix structural constituent;GO:0030020,extracellular matrix structural constituent conferring tensile strength	GO:0001525,angiogenesis;GO:0007155,cell adhesion;GO:0030574,collagen catabolic process;GO:0030199,collagen fibril organization;GO:0001886,endothelial cell morphogenesis;GO:0030198,extracellular matrix organization;GO:0007165,signal transduction	hsa:1306,path:hsa04974,Protein digestion and absorption
PR40A_HUMAN	O75400	PRPF40A	Pre-mRNA-processing factor 40 homolog A	0.462145943	0.43556251	0.56207024	0.853262391	0.4488542265	0.7076663155	0.4488542265	0.7076663155	0.634273833117043	0.347741	0	1.57660610888778	0.347991	0	GO:0016020,membrane;GO:0016363,nuclear matrix;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005685,U1 snRNP;GO:0071004,U2-type prespliceosome	GO:0003723,RNA binding	GO:0007049,cell cycle;GO:0051301,cell division;GO:0016477,cell migration;GO:0007010,cytoskeleton organization;GO:0045292,mRNA cis splicing, via spliceosome;GO:0000398,mRNA splicing, via spliceosome;GO:0008360,regulation of cell shape;GO:0032465,regulation of cytokinesis	hsa:55660,path:hsa03040,Spliceosome
LV147_HUMAN	P01700	IGLV1-47	Immunoglobulin lambda variable 1-47	3.872067208	1.628428129	0.734172249	1.686525548	2.7502476685	1.2103488985	2.7502476685	1.2103488985	2.27227675582505	0.194989	0	0.44008723736511	0.194426	0	GO:0072562,blood microparticle;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0070062,extracellular exosome	GO:0003823,antigen binding	GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
SNX5_HUMAN	Q9Y5X3	SNX5	Sorting nexin-5	1.321367683	1.584992276	1.819125225	2.687004251	1.4531799795	2.253064738	1.4531799795	2.253064738	0.644979238719061	0.357239	0	1.55043750243189	0.357480	0	GO:0005903,brush border;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0005768,endosome;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0031313,extrinsic component of endosome membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0070685,macropinocytic cup;GO:0048471,perinuclear region of cytoplasm;GO:0001891,phagocytic cup;GO:0030904,retromer complex;GO:0030905,retromer, tubulation complex;GO:0001726,ruffle;GO:0097422,tubular endosome	GO:0045296,cadherin binding;GO:0031748,D1 dopamine receptor binding;GO:0034452,dynactin binding;GO:0035091,phosphatidylinositol binding;GO:0080025,phosphatidylinositol-3,5-bisphosphate binding;GO:0070273,phosphatidylinositol-4-phosphate binding;GO:0010314,phosphatidylinositol-5-phosphate binding	GO:0007174,epidermal growth factor catabolic process;GO:0006886,intracellular protein transport;GO:0045776,negative regulation of blood pressure;GO:0006907,pinocytosis;GO:0046628,positive regulation of insulin receptor signaling pathway;GO:0035815,positive regulation of renal sodium excretion;GO:0045893,positive regulation of transcription, DNA-templated;GO:0016241,regulation of macroautophagy;GO:0042147,retrograde transport, endosome to Golgi	hsa:27131,path:hsa04144,Endocytosis
ULA1_HUMAN	Q13564	NAE1	NEDD8-activating enzyme E1 regulatory subunit	0.539162102	0.271622066	0.589995514	1.185888724	0.405392084	0.887942119	0.405392084	0.887942119	0.456552375797369	0.185696	0	2.190329199916	0.186031	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005886,plasma membrane;GO:0032991,protein-containing complex	GO:0019781,NEDD8 activating enzyme activity;GO:0046982,protein heterodimerization activity;GO:0031625,ubiquitin protein ligase binding;GO:0008641,ubiquitin-like modifier activating enzyme activity	GO:0033314,mitotic DNA replication checkpoint;GO:0051402,neuron apoptotic process;GO:0043687,post-translational protein modification;GO:0032446,protein modification by small protein conjugation;GO:0045116,protein neddylation;GO:0042981,regulation of apoptotic process;GO:0043523,regulation of neuron apoptotic process;GO:0007165,signal transduction	hsa:8883,path:hsa05010,Alzheimer disease
RS15A_HUMAN	P62244	RPS15A	40S ribosomal protein S15a	17.64325358	44.68079633	8.098418684	5.92787414	31.162024955	7.013146412	31.162024955	7.013146412	4.44337293481846	0.077092	0	0.22505425825592	0.076615	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0045787,positive regulation of cell cycle;GO:0008284,positive regulation of cell population proliferation;GO:0009615,response to virus;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6210,path:hsa03010,Ribosome
CLIC3_HUMAN	O95833	CLIC3	Chloride intracellular channel protein 3	0.259670313	0.265029673	0.465111643	0.296135998	0.262349993	0.3806238205	0.262349993	0.3806238205	0.689263201276705	0.395748	0	1.45082458797702	0.395953	0	GO:0034707,chloride channel complex;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0016604,nuclear body;GO:0005634,nucleus	GO:0005254,chloride channel activity;GO:0005244,voltage-gated ion channel activity	GO:0006821,chloride transport;GO:0006749,glutathione metabolic process;GO:0034765,regulation of ion transmembrane transport;GO:0007165,signal transduction	
TECR_HUMAN	Q9NZ01	TECR	Very-long-chain enoyl-CoA reductase	2.2278492	1.355297205	2.345774594	2.053284211	1.7915732025	2.1995294025	1.7915732025	2.1995294025	0.814525689205921	0.496337	0	1.22770836236595	0.496432	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0005634,nucleus;GO:0016021,integral component of membrane	GO:0016491,oxidoreductase activity;GO:0102758,very-long-chain enoyl-CoA reductase activity;GO:0017099,very-long-chain-acyl-CoA dehydrogenase activity;GO:0016627,oxidoreductase activity, acting on the CH-CH group of donors	GO:0030497,fatty acid elongation;GO:0035338,long-chain fatty-acyl-CoA biosynthetic process;GO:0006665,sphingolipid metabolic process;GO:0042761,very long-chain fatty acid biosynthetic process;GO:0006629,lipid metabolic process	hsa:9524,path:hsa00062,Fatty acid elongation;hsa:9524,path:hsa01040,Biosynthesis of unsaturated fatty acids
K2C8_HUMAN	P05787	KRT8	Keratin, type II cytoskeletal 8	192.9862903	81.00621888	97.69683147	49.92620994	136.99625459	73.811520705	136.99625459	73.811520705	1.85602807368687	0.245378	0	0.53878495383616	0.244854	0	GO:0016327,apicolateral plasma membrane;GO:0005911,cell-cell junction;GO:0043034,costamere;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016010,dystrophin-associated glycoprotein complex;GO:0070062,extracellular exosome;GO:0005882,intermediate filament;GO:0045111,intermediate filament cytoskeleton;GO:0045095,keratin filament;GO:0016363,nuclear matrix;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0042383,sarcolemma;GO:0030018,Z disc	GO:0044877,protein-containing complex binding;GO:0097110,scaffold protein binding	GO:0060706,cell differentiation involved in embryonic placenta development;GO:0070268,cornification;GO:0097191,extrinsic apoptotic signaling pathway;GO:0097284,hepatocyte apoptotic process;GO:0031424,keratinization;GO:0051599,response to hydrostatic pressure;GO:0051707,response to other organism;GO:0045214,sarcomere organization;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process	
CO4B_HUMAN	P0C0L5	C4B	Complement C4-B	14.83136005	11.9525099	18.66390364	96.31504124	13.391934975	57.48947244	13.391934975	57.48947244	0.232945866549337	0.027290	-1	4.2928428600737	0.027444	1	GO:0030424,axon;GO:0072562,blood microparticle;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0044216,other organism cell;GO:0005886,plasma membrane;GO:0045202,synapse	GO:0030246,carbohydrate binding;GO:0001848,complement binding;GO:0004866,endopeptidase inhibitor activity	GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0032490,detection of molecule of bacterial origin;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0008228,opsonization;GO:2000427,positive regulation of apoptotic cell clearance;GO:0030449,regulation of complement activation	hsa:721,path:hsa04610,Complement and coagulation cascades;hsa:721,path:hsa05322,Systemic lupus erythematosus;hsa:721,path:hsa05133,Pertussis;hsa:721,path:hsa05150,Staphylococcus aureus infection
TMX4_HUMAN	Q9H1E5	TMX4	Thioredoxin-related transmembrane protein 4	0.231344588	0.312946694	0.440627675	1.285076762	0.272145641	0.8628522185	0.272145641	0.8628522185	0.315402377330736	0.072271	0	3.17055314694532	0.072533	0	GO:0016021,integral component of membrane;GO:0005637,nuclear inner membrane			
MTA1_HUMAN	Q13330	MTA1	Metastasis-associated protein MTA1	0.022406153	0.012999292	0.04702698	0.023233375	0.0177027225	0.0351301775	0.0177027225	0.0351301775	0.50391782108132	0.228735	0	1.9844505555572	0.229062	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0005874,microtubule;GO:0005635,nuclear envelope;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016581,NuRD complex	GO:0003682,chromatin binding;GO:0042826,histone deacetylase binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001103,RNA polymerase II repressing transcription factor binding;GO:0003713,transcription coactivator activity;GO:0003714,transcription corepressor activity;GO:0008270,zinc ion binding;GO:0043565,sequence-specific DNA binding	GO:0032922,circadian regulation of gene expression;GO:0006302,double-strand break repair;GO:0043153,entrainment of circadian clock by photoperiod;GO:0016575,histone deacetylation;GO:0045475,locomotor rhythm;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:1902499,positive regulation of protein autoubiquitination;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0040029,regulation of gene expression, epigenetic;GO:0010212,response to ionizing radiation;GO:0007165,signal transduction;GO:0006355,regulation of transcription, DNA-templated	
ARLY_HUMAN	P04424	ASL	Argininosuccinate lyase	0.662724117	1.242689315	2.041239017	1.603033965	0.952706716	1.822136491	0.952706716	1.822136491	0.522851455259067	0.246151	0	1.91258911100192	0.246471	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0004056,argininosuccinate lyase activity;GO:0042802,identical protein binding	GO:0042450,arginine biosynthetic process via ornithine;GO:0000050,urea cycle	hsa:435,path:hsa00250,Alanine, aspartate and glutamate metabolism;hsa:435,path:hsa00220,Arginine biosynthesis
RER1_HUMAN	O15258	RER1	Protein RER1	0.276245073	0.148625953	0.188223824	0.155987078	0.212435513	0.172105451	0.212435513	0.172105451	1.23433343781772	0.364935	0	0.810153860668296	0.364598	0	GO:0009986,cell surface;GO:0005783,endoplasmic reticulum;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,Golgi apparatus;GO:0030173,integral component of Golgi membrane;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0033130,acetylcholine receptor binding	GO:1903078,positive regulation of protein localization to plasma membrane;GO:0006621,protein retention in ER lumen;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0071340,skeletal muscle acetylcholine-gated channel clustering	
NONO_HUMAN	Q15233	NONO	Non-POU domain-containing octamer-binding protein	7.522738079	4.948559305	7.333472985	8.194619502	6.235648692	7.7640462435	6.235648692	7.7640462435	0.803144197810573	0.487760	0	1.24510642388511	0.487864	0	GO:0001650,fibrillar center;GO:0016020,membrane;GO:0016363,nuclear matrix;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0042382,paraspeckles;GO:0090575,RNA polymerase II transcription regulator complex	GO:0003682,chromatin binding;GO:0042802,identical protein binding;GO:0003676,nucleic acid binding;GO:0003723,RNA binding;GO:0000976,transcription regulatory region sequence-specific DNA binding	GO:0002218,activation of innate immune response;GO:0007623,circadian rhythm;GO:0006310,DNA recombination;GO:0006281,DNA repair;GO:0045087,innate immune response;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:1903377,negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:0045892,negative regulation of transcription, DNA-templated;GO:0042752,regulation of circadian rhythm;GO:0006355,regulation of transcription, DNA-templated;GO:0008380,RNA splicing;GO:0048511,rhythmic process	
UBE2N_HUMAN	P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	12.02016577	13.85820911	1.86187023	0.577165947	12.93918744	1.2195180885	12.93918744	1.2195180885	10.610082426834	0.015443	1	0.094249974672289	0.015252	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0001650,fibrillar center;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0031372,UBC13-MMS2 complex;GO:0035370,UBC13-UEV1A complex;GO:0000151,ubiquitin ligase complex	GO:0005524,ATP binding;GO:0003723,RNA binding;GO:0043130,ubiquitin binding;GO:0061631,ubiquitin conjugating enzyme activity;GO:0031625,ubiquitin protein ligase binding;GO:0004842,ubiquitin-protein transferase activity;GO:0016740,transferase activity	GO:0000187,activation of MAPK activity;GO:0035973,aggrephagy;GO:0000729,DNA double-strand break processing;GO:0006302,double-strand break repair;GO:0000724,double-strand break repair via homologous recombination;GO:0006303,double-strand break repair via nonhomologous end joining;GO:0016574,histone ubiquitination;GO:0070498,interleukin-1-mediated signaling pathway;GO:0007254,JNK cascade;GO:0070423,nucleotide-binding oligomerization domain containing signaling pathway;GO:0045739,positive regulation of DNA repair;GO:0031058,positive regulation of histone modification;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0051443,positive regulation of ubiquitin-protein transferase activity;GO:0006301,postreplication repair;GO:0070534,protein K63-linked ubiquitination;GO:0000209,protein polyubiquitination;GO:0016567,protein ubiquitination;GO:0006282,regulation of DNA repair;GO:0033182,regulation of histone ubiquitination;GO:0050852,T cell receptor signaling pathway;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:7334,path:hsa04120,Ubiquitin mediated proteolysis;hsa:7334,path:hsa05131,Shigellosis
CAZA1_HUMAN	P52907	CAPZA1	F-actin-capping protein subunit alpha-1	6.718237162	6.793960266	13.077081	3.642889105	6.756098714	8.3599850525	6.756098714	8.3599850525	0.808147224136439	0.491544	0	1.23739829839615	0.491645	0	GO:0015629,actin cytoskeleton;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0008290,F-actin capping protein complex;GO:0071203,WASH complex	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0045296,cadherin binding	GO:0030036,actin cytoskeleton organization;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0051016,barbed-end actin filament capping;GO:0007596,blood coagulation;GO:0034329,cell junction assembly;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0045087,innate immune response;GO:0035722,interleukin-12-mediated signaling pathway;GO:0065003,protein-containing complex assembly	hsa:829,path:hsa04144,Endocytosis
ARRB1_HUMAN	P49407	ARRB1	Beta-arrestin-1	0.494831835	0.442522689	0.757901226	1.529814287	0.468677262	1.1438577565	0.468677262	1.1438577565	0.409733867114796	0.144751	0	2.44060860050855	0.145080	0	GO:0016323,basolateral plasma membrane;GO:0000785,chromatin;GO:0005905,clathrin-coated pit;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0005768,endosome;GO:0000139,Golgi membrane;GO:0005765,lysosomal membrane;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0045211,postsynaptic membrane;GO:0031143,pseudopodium	GO:0031691,alpha-1A adrenergic receptor binding;GO:0031692,alpha-1B adrenergic receptor binding;GO:0031701,angiotensin receptor binding;GO:0035612,AP-2 adaptor complex binding;GO:1990763,arrestin family protein binding;GO:0035615,clathrin adaptor activity;GO:0004857,enzyme inhibitor activity;GO:0030331,estrogen receptor binding;GO:0031762,follicle-stimulating hormone receptor binding;GO:0001664,G protein-coupled receptor binding;GO:0005096,GTPase activator activity;GO:0005159,insulin-like growth factor receptor binding;GO:0044325,ion channel binding;GO:0045309,protein phosphorylated amino acid binding;GO:0003713,transcription coactivator activity;GO:0008134,transcription factor binding;GO:0031625,ubiquitin protein ligase binding;GO:0031896,V2 vasopressin receptor binding	GO:0000187,activation of MAPK activity;GO:0042699,follicle-stimulating hormone signaling pathway;GO:0002031,G protein-coupled receptor internalization;GO:0007186,G protein-coupled receptor signaling pathway;GO:0016573,histone acetylation;GO:0061024,membrane organization;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:0034260,negative regulation of GTPase activity;GO:0032715,negative regulation of interleukin-6 production;GO:0032717,negative regulation of interleukin-8 production;GO:0043524,negative regulation of neuron apoptotic process;GO:0032088,negative regulation of NF-kappaB transcription factor activity;GO:0045746,negative regulation of Notch signaling pathway;GO:0001933,negative regulation of protein phosphorylation;GO:0031397,negative regulation of protein ubiquitination;GO:0030168,platelet activation;GO:0008284,positive regulation of cell population proliferation;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0035066,positive regulation of histone acetylation;GO:0090240,positive regulation of histone H4 acetylation;GO:0001934,positive regulation of protein phosphorylation;GO:0031398,positive regulation of protein ubiquitination;GO:0002092,positive regulation of receptor internalization;GO:0035025,positive regulation of Rho protein signal transduction;GO:0034393,positive regulation of smooth muscle cell apoptotic process;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0006892,post-Golgi vesicle-mediated transport;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0015031,protein transport;GO:0016567,protein ubiquitination;GO:0006357,regulation of transcription by RNA polymerase II;GO:0042493,response to drug;GO:0043149,stress fiber assembly;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0007165,signal transduction	hsa:408,path:hsa04010,MAPK signaling pathway;hsa:408,path:hsa04340,Hedgehog signaling pathway;hsa:408,path:hsa04144,Endocytosis;hsa:408,path:hsa04062,Chemokine signaling pathway;hsa:408,path:hsa04929,GnRH secretion;hsa:408,path:hsa04926,Relaxin signaling pathway;hsa:408,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:408,path:hsa04728,Dopaminergic synapse;hsa:408,path:hsa04740,Olfactory transduction;hsa:408,path:hsa05032,Morphine addiction
C1R_HUMAN	P00736	C1R	Complement C1r subcomponent	0.268038481	0.251182477	0.468965022	2.484802371	0.259610479	1.4768836965	0.259610479	1.4768836965	0.175782615527031	0.009324	-1	5.68884469605713	0.009398	1	GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0005509,calcium ion binding;GO:0042802,identical protein binding;GO:0004252,serine-type endopeptidase activity;GO:0008236,serine-type peptidase activity	GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0006955,immune response;GO:0045087,innate immune response;GO:0030449,regulation of complement activation;GO:0031638,zymogen activation	hsa:715,path:hsa04145,Phagosome;hsa:715,path:hsa04610,Complement and coagulation cascades;hsa:715,path:hsa05322,Systemic lupus erythematosus;hsa:715,path:hsa05133,Pertussis;hsa:715,path:hsa05150,Staphylococcus aureus infection
K2C78_HUMAN	Q8N1N4	KRT78	Keratin, type II cytoskeletal 78	1.383125036	0.568540773	0.635499739	0.168993638	0.9758329045	0.4022466885	0.9758329045	0.4022466885	2.42595634071951	0.180144	0	0.412208572435979	0.179575	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0045095,keratin filament;GO:0005882,intermediate filament		GO:0070268,cornification;GO:0031424,keratinization	
RHEB_HUMAN	Q15382	RHEB	GTP-binding protein Rheb	1.330540529	1.716614033	0.293648614	0.144405277	1.523577281	0.2190269455	1.523577281	0.2190269455	6.95611801334279	0.035719	1	0.143758343099105	0.035394	-1	GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0000139,Golgi membrane;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0005681,spliceosomal complex	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0000287,magnesium ion binding;GO:0019901,protein kinase binding	GO:0007050,cell cycle arrest;GO:0034198,cellular response to amino acid starvation;GO:0120163,negative regulation of cold-induced thermogenesis;GO:0048714,positive regulation of oligodendrocyte differentiation;GO:0032008,positive regulation of TOR signaling;GO:0016241,regulation of macroautophagy;GO:2000074,regulation of type B pancreatic cell development;GO:0007165,signal transduction;GO:0007264,small GTPase mediated signal transduction	hsa:6009,path:hsa04072,Phospholipase D signaling pathway;hsa:6009,path:hsa04151,PI3K-Akt signaling pathway;hsa:6009,path:hsa04152,AMPK signaling pathway;hsa:6009,path:hsa04150,mTOR signaling pathway;hsa:6009,path:hsa04140,Autophagy - animal;hsa:6009,path:hsa04218,Cellular senescence;hsa:6009,path:hsa04910,Insulin signaling pathway;hsa:6009,path:hsa04919,Thyroid hormone signaling pathway;hsa:6009,path:hsa04211,Longevity regulating pathway;hsa:6009,path:hsa04714,Thermogenesis;hsa:6009,path:hsa05231,Choline metabolism in cancer;hsa:6009,path:hsa05168,Herpes simplex virus 1 infection;hsa:6009,path:hsa05163,Human cytomegalovirus infection;hsa:6009,path:hsa05165,Human papillomavirus infection
FKB1A_HUMAN	P62942	FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	0.139168901	0.530049708	0.504016914	0.320014635	0.3346093045	0.4120157745	0.3346093045	0.4120157745	0.812127411641129	0.494539	0	1.2313338839028	0.494636	0	GO:0005737,cytoplasm;GO:0098562,cytoplasmic side of membrane;GO:0005829,cytosol;GO:0031312,extrinsic component of organelle membrane;GO:0016020,membrane;GO:1990425,ryanodine receptor complex;GO:0016529,sarcoplasmic reticulum;GO:0014802,terminal cisterna;GO:0030018,Z disc;GO:0016021,integral component of membrane	GO:0048185,activin binding;GO:0005528,FK506 binding;GO:0044325,ion channel binding;GO:0005527,macrolide binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity;GO:0046332,SMAD binding;GO:0005160,transforming growth factor beta receptor binding;GO:0034713,type I transforming growth factor beta receptor binding	GO:0006458,'de novo' protein folding;GO:1990000,amyloid fibril formation;GO:0070588,calcium ion transmembrane transport;GO:0061077,chaperone-mediated protein folding;GO:0003007,heart morphogenesis;GO:0060347,heart trabecula formation;GO:0032515,negative regulation of phosphoprotein phosphatase activity;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0032092,positive regulation of protein binding;GO:0031398,positive regulation of protein ubiquitination;GO:0006457,protein folding;GO:0022417,protein maturation by protein folding;GO:0000413,protein peptidyl-prolyl isomerization;GO:0042026,protein refolding;GO:0032925,regulation of activin receptor signaling pathway;GO:1902991,regulation of amyloid precursor protein catabolic process;GO:0050776,regulation of immune response;GO:0032880,regulation of protein localization;GO:0060314,regulation of ryanodine-sensitive calcium-release channel activity;GO:0007183,SMAD protein complex assembly;GO:0097435,supramolecular fiber organization;GO:0042110,T cell activation;GO:0007179,transforming growth factor beta receptor signaling pathway;GO:0055010,ventricular cardiac muscle tissue morphogenesis	
GPC1_HUMAN	P35052	GPC1	Glypican-1	0.1082174	0.339587389	0.344488277	1.050871914	0.2239023945	0.6976800955	0.2239023945	0.6976800955	0.320924154127599	0.075991	0	3.11600104616121	0.076259	0	GO:0046658,anchored component of plasma membrane;GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0005829,cytosol;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005796,Golgi lumen;GO:0031226,intrinsic component of plasma membrane;GO:0043202,lysosomal lumen;GO:0045121,membrane raft;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0045202,synapse	GO:0005507,copper ion binding;GO:0017134,fibroblast growth factor binding;GO:0043236,laminin binding	GO:0007411,axon guidance;GO:0016477,cell migration;GO:0006024,glycosaminoglycan biosynthetic process;GO:0006027,glycosaminoglycan catabolic process;GO:0030200,heparan sulfate proteoglycan catabolic process;GO:0050900,leukocyte migration;GO:0032288,myelin assembly;GO:0040037,negative regulation of fibroblast growth factor receptor signaling pathway;GO:2001016,positive regulation of skeletal muscle cell differentiation;GO:1905475,regulation of protein localization to membrane;GO:0001523,retinoid metabolic process;GO:0014037,Schwann cell differentiation;GO:0009966,regulation of signal transduction	hsa:2817,path:hsa05205,Proteoglycans in cancer;hsa:2817,path:hsa05418,Fluid shear stress and atherosclerosis
EIF3F_HUMAN	O00303	EIF3F	Eukaryotic translation initiation factor 3 subunit F	3.112101046	2.057503988	4.716133351	3.95433055	2.584802517	4.3352319505	2.584802517	4.3352319505	0.596231654156794	0.313501	0	1.67720045225412	0.313780	0	GO:0005829,cytosol;GO:0016282,eukaryotic 43S preinitiation complex;GO:0033290,eukaryotic 48S preinitiation complex;GO:0005852,eukaryotic translation initiation factor 3 complex;GO:0071541,eukaryotic translation initiation factor 3 complex, eIF3m;GO:0016020,membrane	GO:0101005,deubiquitinase activity;GO:0042802,identical protein binding;GO:0070122,isopeptidase activity;GO:0008237,metallopeptidase activity;GO:0004843,thiol-dependent deubiquitinase;GO:0003743,translation initiation factor activity;GO:0031369,translation initiation factor binding	GO:0001732,formation of cytoplasmic translation initiation complex;GO:0075522,IRES-dependent viral translational initiation;GO:0016579,protein deubiquitination;GO:0006413,translational initiation	hsa:8665,path:hsa03013,RNA transport
RHG18_HUMAN	Q8N392	ARHGAP18	Rho GTPase-activating protein 18	0.495337131	0.655361378	0.875962574	1.253766106	0.5753492545	1.06486434	0.5753492545	1.06486434	0.54030286571527	0.262232	0	1.85081379991603	0.262545	0	GO:0005737,cytoplasm;GO:0005881,cytoplasmic microtubule;GO:0005829,cytosol;GO:0016607,nuclear speck;GO:0005886,plasma membrane;GO:0001726,ruffle	GO:0045296,cadherin binding;GO:0005096,GTPase activator activity	GO:0032956,regulation of actin cytoskeleton organization;GO:0030833,regulation of actin filament polymerization;GO:2000145,regulation of cell motility;GO:0008360,regulation of cell shape;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007264,small GTPase mediated signal transduction	
GBP2_HUMAN	P32456	GBP2	Guanylate-binding protein 2	0.533735229	0.434624108	0.558229874	0.380364154	0.4841796685	0.469297014	0.4841796685	0.469297014	1.03171265543147	0.423024	0	0.969262124231472	0.422805	0	GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity	GO:0071346,cellular response to interferon-gamma;GO:0071347,cellular response to interleukin-1;GO:0071356,cellular response to tumor necrosis factor;GO:0050830,defense response to Gram-positive bacterium;GO:0042832,defense response to protozoan;GO:0006955,immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0034504,protein localization to nucleus;GO:0060337,type I interferon signaling pathway	hsa:2634,path:hsa04621,NOD-like receptor signaling pathway
HEBP2_HUMAN	Q9Y5Z4	HEBP2	Heme-binding protein 2	3.558086021	3.06515218	2.198309613	10.93009422	3.3116191005	6.5642019165	3.3116191005	6.5642019165	0.504496836420556	0.229266	0	1.98217298466146	0.229593	0	GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005739,mitochondrion	GO:0020037,heme binding	GO:0010917,negative regulation of mitochondrial membrane potential;GO:0043312,neutrophil degranulation;GO:0035794,positive regulation of mitochondrial membrane permeability;GO:0010940,positive regulation of necrotic cell death	
PRAF3_HUMAN	O75915	ARL6IP5	PRA1 family protein 3	3.648702474	8.236812412	6.092200487	8.395377319	5.942757443	7.243788903	5.942757443	7.243788903	0.820393515407223	0.499607	0	1.21892723579565	0.499556	0	GO:0005856,cytoskeleton;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane		GO:0071407,cellular response to organic cyclic compound;GO:0006749,glutathione metabolic process;GO:0008631,intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0098712,L-glutamate import across plasma membrane;GO:0015813,L-glutamate transmembrane transport;GO:0007611,learning or memory;GO:0002037,negative regulation of L-glutamate import across plasma membrane;GO:0010917,negative regulation of mitochondrial membrane potential;GO:0051051,negative regulation of transport;GO:0036475,neuron death in response to oxidative stress;GO:0043065,positive regulation of apoptotic process;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0032874,positive regulation of stress-activated MAPK cascade;GO:0072659,protein localization to plasma membrane;GO:0015031,protein transport	
DCXR_HUMAN	Q7Z4W1	DCXR	L-xylulose reductase	2.817575146	4.017447651	2.678442655	3.661712715	3.4175113985	3.170077685	3.4175113985	3.170077685	1.07805288642319	0.408582	0	0.927598277036149	0.408332	0	GO:0005903,brush border;GO:0005881,cytoplasmic microtubule;GO:0070062,extracellular exosome;GO:0005902,microvillus;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0004090,carbonyl reductase (NADPH) activity;GO:0042802,identical protein binding;GO:0044105,L-xylulose reductase (NAD+) activity;GO:0050038,L-xylulose reductase (NADP+) activity;GO:0016655,oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0016491,oxidoreductase activity	GO:0042732,D-xylose metabolic process;GO:0006006,glucose metabolic process;GO:0019640,glucuronate catabolic process to xylulose 5-phosphate;GO:0006739,NADP metabolic process;GO:2000379,positive regulation of reactive oxygen species metabolic process;GO:0005997,xylulose metabolic process	hsa:51181,path:hsa00040,Pentose and glucuronate interconversions
RS17_HUMAN	P08708	RPS17	40S ribosomal protein S17	1.945897319	0.803947425	0.153069627	0.016603501	1.374922372	0.084836564	1.374922372	0.084836564	16.2067192160211	0.005942	1	0.0617028028110375	0.005846	-1	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0034101,erythrocyte homeostasis;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0042274,ribosomal small subunit biogenesis;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6218,path:hsa03010,Ribosome
RPAB3_HUMAN	P52434	POLR2H	DNA-directed RNA polymerases I, II, and III subunit RPABC3	0.759980096	10.41953213	0.062072357	0.03895023	5.589756113	0.0505112935	5.589756113	0.0505112935	110.663491779319	0.000018	1	0.00903640382136293	0.000017	-1	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032993,protein-DNA complex;GO:0005736,RNA polymerase I complex;GO:0005665,RNA polymerase II, core complex;GO:0005666,RNA polymerase III complex	GO:0003899,DNA-directed 5'-3' RNA polymerase activity;GO:0003697,single-stranded DNA binding	GO:0006370,7-methylguanosine mRNA capping;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0000398,mRNA splicing, via spliceosome;GO:0048239,negative regulation of DNA recombination at telomere;GO:0045815,positive regulation of gene expression, epigenetic;GO:0032481,positive regulation of type I interferon production;GO:0050434,positive regulation of viral transcription;GO:0060964,regulation of gene silencing by miRNA;GO:0016070,RNA metabolic process;GO:0042795,snRNA transcription by RNA polymerase II;GO:0006363,termination of RNA polymerase I transcription;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter;GO:0006361,transcription initiation from RNA polymerase I promoter;GO:0006367,transcription initiation from RNA polymerase II promoter;GO:0006351,transcription, DNA-templated;GO:0006283,transcription-coupled nucleotide-excision repair	hsa:5437,path:hsa03020,RNA polymerase;hsa:5437,path:hsa04623,Cytosolic DNA-sensing pathway;hsa:5437,path:hsa05016,Huntington disease
IMPA1_HUMAN	P29218	IMPA1	Inositol monophosphatase 1	0.353816561	0.426548431	0.664458568	0.511406829	0.390182496	0.5879326985	0.390182496	0.5879326985	0.663651633929321	0.373637	0	1.50681464321762	0.373864	0	GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0042802,identical protein binding;GO:0008934,inositol monophosphate 1-phosphatase activity;GO:0052832,inositol monophosphate 3-phosphatase activity;GO:0052833,inositol monophosphate 4-phosphatase activity;GO:0052834,inositol monophosphate phosphatase activity;GO:0031403,lithium ion binding;GO:0000287,magnesium ion binding;GO:0030145,manganese ion binding;GO:0042803,protein homodimerization activity;GO:0046872,metal ion binding	GO:0006021,inositol biosynthetic process;GO:0006020,inositol metabolic process;GO:0046855,inositol phosphate dephosphorylation;GO:0043647,inositol phosphate metabolic process;GO:0006796,phosphate-containing compound metabolic process;GO:0006661,phosphatidylinositol biosynthetic process;GO:0046854,phosphatidylinositol phosphorylation;GO:0007165,signal transduction	hsa:3612,path:hsa00562,Inositol phosphate metabolism;hsa:3612,path:hsa04070,Phosphatidylinositol signaling system
PTN23_HUMAN	Q9H3S7	PTPN23	Tyrosine-protein phosphatase non-receptor type 23	6.064761273	6.640539308	4.159483184	8.070170513	6.3526502905	6.1148268485	6.3526502905	6.1148268485	1.03889291518669	0.420737	0	0.96256311442869	0.420513	0	GO:0036064,ciliary basal body;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005769,early endosome;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0019901,protein kinase binding;GO:0004725,protein tyrosine phosphatase activity	GO:0071345,cellular response to cytokine stimulus;GO:0060271,cilium assembly;GO:0045022,early endosome to late endosome transport;GO:0032456,endocytic recycling;GO:0010633,negative regulation of epithelial cell migration;GO:1903393,positive regulation of adherens junction organization;GO:2000643,positive regulation of early endosome to late endosome transport;GO:1903387,positive regulation of homophilic cell adhesion;GO:0061357,positive regulation of Wnt protein secretion;GO:0015031,protein transport;GO:0043162,ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	
FACE1_HUMAN	O75844	ZMPSTE24	CAAX prenyl protease 1 homolog	0.64401613	0.806368813	0.95378815	0.821899478	0.7251924715	0.887843814	0.7251924715	0.887843814	0.816801851930231	0.498038	0	1.22428713602552	0.498131	0	GO:0070062,extracellular exosome;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016020,membrane;GO:0005637,nuclear inner membrane;GO:0032991,protein-containing complex;GO:0016021,integral component of membrane;GO:0005789,endoplasmic reticulum membrane	GO:0003690,double-stranded DNA binding;GO:0046872,metal ion binding;GO:0004222,metalloendopeptidase activity;GO:0008235,metalloexopeptidase activity;GO:0008233,peptidase activity	GO:0007628,adult walking behavior;GO:0030282,bone mineralization;GO:0071586,CAAX-box protein processing;GO:1990036,calcium ion import into sarcoplasmic reticulum;GO:0061762,CAMKK-AMPK signaling cascade;GO:0061337,cardiac conduction;GO:0048739,cardiac muscle fiber development;GO:0003231,cardiac ventricle development;GO:0044255,cellular lipid metabolic process;GO:0071480,cellular response to gamma radiation;GO:0008340,determination of adult lifespan;GO:0006281,DNA repair;GO:0003417,growth plate cartilage development;GO:0001942,hair follicle development;GO:0003007,heart morphogenesis;GO:1990164,histone H2A phosphorylation;GO:0043979,histone H2B-K5 acetylation;GO:0044029,hypomethylation of CpG island;GO:0006925,inflammatory cell apoptotic process;GO:0060993,kidney morphogenesis;GO:0001889,liver development;GO:0043007,maintenance of rDNA;GO:0035264,multicellular organism growth;GO:1903799,negative regulation of production of miRNAs involved in gene silencing by miRNA;GO:0050905,neuromuscular process;GO:0006998,nuclear envelope organization;GO:0030327,prenylated protein catabolic process;GO:0006508,proteolysis;GO:0010506,regulation of autophagy;GO:0030500,regulation of bone mineralization;GO:0008360,regulation of cell shape;GO:2000772,regulation of cellular senescence;GO:0050688,regulation of defense response to virus;GO:0043516,regulation of DNA damage response, signal transduction by p53 class mediator;GO:0048145,regulation of fibroblast proliferation;GO:0010906,regulation of glucose metabolic process;GO:2000618,regulation of histone H4-K16 acetylation;GO:0032350,regulation of hormone metabolic process;GO:0019216,regulation of lipid metabolic process;GO:1903463,regulation of mitotic cell cycle DNA replication;GO:0040014,regulation of multicellular organism growth;GO:1903025,regulation of RNA polymerase II regulatory region sequence-specific DNA binding;GO:0070302,regulation of stress-activated protein kinase signaling cascade;GO:2000730,regulation of termination of RNA polymerase I transcription;GO:0032006,regulation of TOR signaling;GO:0060307,regulation of ventricular cardiac muscle cell membrane repolarization;GO:0072423,response to DNA damage checkpoint signaling;GO:0048538,thymus development;GO:0003229,ventricular cardiac muscle tissue development	hsa:10269,path:hsa00900,Terpenoid backbone biosynthesis
FA98A_HUMAN	Q8NCA5	FAM98A	Protein FAM98A	0.10200548	0.021108109	0.192706279	2.55E-05	0.0615567945	0.0963658895	0.0615567945	0.0963658895	0.638781988309255	0.351749	0	1.56547933144894	0.351995	0	GO:0072669,tRNA-splicing ligase complex	GO:0008276,protein methyltransferase activity;GO:0003723,RNA binding	GO:0032418,lysosome localization;GO:0008284,positive regulation of cell population proliferation;GO:0010628,positive regulation of gene expression;GO:1900029,positive regulation of ruffle assembly;GO:0006479,protein methylation	
PTPRF_HUMAN	P10586	PTPRF	Receptor-type tyrosine-protein phosphatase F	0.222756806	0.258119119	0.316725205	0.982149965	0.2404379625	0.649437585	0.2404379625	0.649437585	0.370224896207693	0.112341	0	2.70106092335565	0.112651	0	GO:0070062,extracellular exosome;GO:0005887,integral component of plasma membrane;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0050839,cell adhesion molecule binding;GO:0035373,chondroitin sulfate proteoglycan binding;GO:0008201,heparin binding;GO:0004725,protein tyrosine phosphatase activity;GO:0044877,protein-containing complex binding;GO:0005001,transmembrane receptor protein tyrosine phosphatase activity	GO:0007155,cell adhesion;GO:0016477,cell migration;GO:1900121,negative regulation of receptor binding;GO:0031102,neuron projection regeneration;GO:0035335,peptidyl-tyrosine dephosphorylation;GO:0006470,protein dephosphorylation;GO:0048679,regulation of axon regeneration;GO:0099560,synaptic membrane adhesion;GO:0007185,transmembrane receptor protein tyrosine phosphatase signaling pathway	hsa:5792,path:hsa04514,Cell adhesion molecules (CAMs);hsa:5792,path:hsa04520,Adherens junction;hsa:5792,path:hsa04910,Insulin signaling pathway;hsa:5792,path:hsa04931,Insulin resistance
LG3BP_HUMAN	Q08380	LGALS3BP	Galectin-3-binding protein	4.198429513	6.164543339	4.769820642	4.962189413	5.181486426	4.8660050275	5.181486426	4.8660050275	1.06483375925776	0.412626	0	0.939113726725799	0.412385	0	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0016020,membrane;GO:0031089,platelet dense granule lumen	GO:0005044,scavenger receptor activity	GO:0007155,cell adhesion;GO:0006968,cellular defense response;GO:0002576,platelet degranulation;GO:0007165,signal transduction	
PTGIS_HUMAN	Q16647	PTGIS	Prostacyclin synthase	1.711115991	0.470595932	2.12548123	3.008935315	1.0908559615	2.5672082725	1.0908559615	2.5672082725	0.424919151743657	0.157785	0	2.35338886443808	0.158118	0	GO:0005901,caveola;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005615,extracellular space;GO:0016021,integral component of membrane;GO:0005634,nucleus	GO:0020037,heme binding;GO:0106256,hydroperoxy icosatetraenoate dehydratase activity;GO:0005506,iron ion binding;GO:0004497,monooxygenase activity;GO:0016705,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0008116,prostaglandin-I synthase activity	GO:0097190,apoptotic signaling pathway;GO:0071456,cellular response to hypoxia;GO:0071347,cellular response to interleukin-1;GO:0071354,cellular response to interleukin-6;GO:0019371,cyclooxygenase pathway;GO:0006690,icosanoid metabolic process;GO:0034356,NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0050728,negative regulation of inflammatory response;GO:0032088,negative regulation of NF-kappaB transcription factor activity;GO:0045019,negative regulation of nitric oxide biosynthetic process;GO:0045766,positive regulation of angiogenesis;GO:1900119,positive regulation of execution phase of apoptosis;GO:0035360,positive regulation of peroxisome proliferator activated receptor signaling pathway;GO:0001516,prostaglandin biosynthetic process	hsa:5740,path:hsa00590,Arachidonic acid metabolism
UB2L6_HUMAN	O14933	UBE2L6	Ubiquitin/ISG15-conjugating enzyme E2 L6	3.803377202	0.787513555	1.722045386	6.370321239	2.2954453785	4.0461833125	2.2954453785	4.0461833125	0.567311266251484	0.287080	0	1.76270075968614	0.287378	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000151,ubiquitin ligase complex	GO:0042296,ISG15 transferase activity;GO:0043130,ubiquitin binding;GO:0061631,ubiquitin conjugating enzyme activity;GO:0031625,ubiquitin protein ligase binding;GO:0004842,ubiquitin-protein transferase activity;GO:0005524,ATP binding;GO:0016740,transferase activity	GO:1990000,amyloid fibril formation;GO:0006464,cellular protein modification process;GO:0032020,ISG15-protein conjugation;GO:0032480,negative regulation of type I interferon production;GO:0000209,protein polyubiquitination;GO:0019985,translesion synthesis;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:9246,path:hsa04120,Ubiquitin mediated proteolysis;hsa:9246,path:hsa05012,Parkinson disease
TMX3_HUMAN	Q96JJ7	TMX3	Protein disulfide-isomerase TMX3	0.258957211	0.098601156	0.505030648	0.516525033	0.1787791835	0.5107778405	0.1787791835	0.5107778405	0.350013585798854	0.096806	0	2.85703195696718	0.097102	0	GO:0009986,cell surface;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0005886,plasma membrane;GO:0031092,platelet alpha granule membrane	GO:0003756,protein disulfide isomerase activity;GO:0016972,thiol oxidase activity;GO:0016853,isomerase activity	GO:0018171,peptidyl-cysteine oxidation;GO:0002576,platelet degranulation	
ECM1_HUMAN	Q16610	ECM1	Extracellular matrix protein 1	0.048617364	0.169212252	0.039471037	0.161378859	0.108914808	0.100424948	0.108914808	0.100424948	1.08453935171567	0.406619	0	0.922050452496781	0.406365	0	GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0031089,platelet dense granule lumen	GO:0019899,enzyme binding;GO:0005134,interleukin-2 receptor binding;GO:0043236,laminin binding;GO:0002020,protease binding;GO:0008022,protein C-terminus binding	GO:0001525,angiogenesis;GO:0031214,biomineral tissue development;GO:0002063,chondrocyte development;GO:0003416,endochondral bone growth;GO:0006954,inflammatory response;GO:0030502,negative regulation of bone mineralization;GO:0001960,negative regulation of cytokine-mediated signaling pathway;GO:0010466,negative regulation of peptidase activity;GO:0001503,ossification;GO:0002576,platelet degranulation;GO:0045766,positive regulation of angiogenesis;GO:0001938,positive regulation of endothelial cell proliferation;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0030500,regulation of bone mineralization;GO:2000404,regulation of T cell migration;GO:0006357,regulation of transcription by RNA polymerase II;GO:0002828,regulation of type 2 immune response;GO:0007165,signal transduction	
PRG3_HUMAN	Q9Y2Y8	PRG3	Proteoglycan 3	0.313169873	1.800433008	0.275662132	0.051975848	1.0568014405	0.16381899	1.0568014405	0.16381899	6.45103135173767	0.041004	1	0.155013973034038	0.040653	-1	GO:0062023,collagen-containing extracellular matrix;GO:0005576,extracellular region;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen	GO:0030246,carbohydrate binding;GO:0030021,extracellular matrix structural constituent conferring compression resistance	GO:0045575,basophil activation;GO:0001694,histamine biosynthetic process;GO:0019370,leukotriene biosynthetic process;GO:0017148,negative regulation of translation;GO:0042119,neutrophil activation;GO:0043312,neutrophil degranulation;GO:0032757,positive regulation of interleukin-8 production;GO:0042554,superoxide anion generation	
RL27A_HUMAN	P46776	RPL27A	60S ribosomal protein L27a	3.763646683	4.554544322	1.260506311	0.745765581	4.1590955025	1.003135946	4.1590955025	1.003135946	4.14609357693179	0.085885	0	0.241190890037755	0.085388	0	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0005783,endoplasmic reticulum;GO:0016020,membrane;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6157,path:hsa03010,Ribosome
STIM1_HUMAN	Q13586	STIM1	Stromal interaction molecule 1	0.811627495	0.969177934	0.821900599	0.900026056	0.8904027145	0.8609633275	0.8904027145	0.8609633275	1.03419354351071	0.422232	0	0.966936997697125	0.422011	0	GO:0032541,cortical endoplasmic reticulum;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0005887,integral component of plasma membrane;GO:0005874,microtubule;GO:0005886,plasma membrane;GO:0044853,plasma membrane raft;GO:0033017,sarcoplasmic reticulum membrane;GO:0030426,growth cone	GO:0005246,calcium channel regulator activity;GO:0005509,calcium ion binding;GO:0042802,identical protein binding;GO:0051010,microtubule plus-end binding;GO:0002020,protease binding;GO:0046872,metal ion binding;GO:0015279,store-operated calcium channel activity	GO:0032237,activation of store-operated calcium channel activity;GO:0006874,cellular calcium ion homeostasis;GO:0005513,detection of calcium ion;GO:0070166,enamel mineralization;GO:0045762,positive regulation of adenylate cyclase activity;GO:0045766,positive regulation of angiogenesis;GO:0051924,regulation of calcium ion transport;GO:1903779,regulation of cardiac conduction;GO:2001256,regulation of store-operated calcium entry;GO:0002115,store-operated calcium entry	hsa:6786,path:hsa04020,Calcium signaling pathway;hsa:6786,path:hsa04611,Platelet activation
IF4H_HUMAN	Q15056	EIF4H	Eukaryotic translation initiation factor 4H	3.427542277	6.414165361	0.360347154	0.237060868	4.920853819	0.298704011	4.920853819	0.298704011	16.4740131962942	0.005713	1	0.0607016631639551	0.005620	-1	GO:0005829,cytosol;GO:0016281,eukaryotic translation initiation factor 4F complex;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm	GO:0045296,cadherin binding;GO:0043024,ribosomal small subunit binding;GO:0003723,RNA binding;GO:0033592,RNA strand annealing activity;GO:0034057,RNA strand-exchange activity;GO:0008135,translation factor activity, RNA binding;GO:0003743,translation initiation factor activity	GO:0048589,developmental growth;GO:0097010,eukaryotic translation initiation factor 4F complex assembly;GO:0001731,formation of translation preinitiation complex;GO:0006446,regulation of translational initiation;GO:0019953,sexual reproduction;GO:0006413,translational initiation;GO:0016032,viral process	
SYFA_HUMAN	Q9Y285	FARSA	Phenylalanine--tRNA ligase alpha subunit	0.03748019	0.031090326	0.111819579	0.02819661	0.034285258	0.0700080945	0.034285258	0.0700080945	0.489732769401401	0.215742	0	2.04192993093416	0.216073	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0009328,phenylalanine-tRNA ligase complex	GO:0005524,ATP binding;GO:0004826,phenylalanine-tRNA ligase activity;GO:0003723,RNA binding;GO:0000049,tRNA binding;GO:0004812,aminoacyl-tRNA ligase activity	GO:0006432,phenylalanyl-tRNA aminoacylation;GO:0051290,protein heterotetramerization;GO:0006418,tRNA aminoacylation for protein translation;GO:0006412,translation;GO:0043039,tRNA aminoacylation	hsa:2193,path:hsa00970,Aminoacyl-tRNA biosynthesis
NUP93_HUMAN	Q8N1F7	NUP93	Nuclear pore complex protein Nup93	1.686286895	2.851213903	3.087597153	3.846923146	2.268750399	3.4672601495	2.268750399	3.4672601495	0.654335210274651	0.365483	0	1.52826866764553	0.365717	0	GO:0005829,cytosol;GO:0043657,host cell;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0034399,nuclear periphery;GO:0005643,nuclear pore;GO:0005813,centrosome	GO:0017056,structural constituent of nuclear pore	GO:0075733,intracellular transport of virus;GO:0007084,mitotic nuclear envelope reassembly;GO:0006406,mRNA export from nucleus;GO:0006998,nuclear envelope organization;GO:0051292,nuclear pore complex assembly;GO:0016973,poly(A)+ mRNA export from nucleus;GO:0060391,positive regulation of SMAD protein signal transduction;GO:0006606,protein import into nucleus;GO:0016925,protein sumoylation;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0060395,SMAD protein signal transduction;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription;GO:0051028,mRNA transport;GO:0015031,protein transport	hsa:9688,path:hsa03013,RNA transport
RAB8B_HUMAN	Q92930	RAB8B	Ras-related protein Rab-8B	0.218320352	1.418155788	0.048213714	0.018546323	0.81823807	0.0333800185	0.81823807	0.0333800185	24.5128105606053	0.002089	1	0.0407949956422829	0.002047	-1	GO:0051286,cell tip;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm;GO:0005778,peroxisomal membrane;GO:0045335,phagocytic vesicle;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0008021,synaptic vesicle;GO:0030140,trans-Golgi network transport vesicle	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0005102,signaling receptor binding;GO:0030911,TPR domain binding	GO:0019882,antigen processing and presentation;GO:0150115,cell-substrate junction organization;GO:0032869,cellular response to insulin stimulus;GO:0048210,Golgi vesicle fusion to target membrane;GO:0031346,positive regulation of cell projection organization;GO:0051461,positive regulation of corticotropin secretion;GO:0045046,protein import into peroxisome membrane;GO:0072659,protein localization to plasma membrane;GO:0009306,protein secretion;GO:0017157,regulation of exocytosis;GO:0006904,vesicle docking involved in exocytosis	hsa:51762,path:hsa04530,Tight junction
GNAI1_HUMAN	P63096	GNAI1	Guanine nucleotide-binding protein G(i) subunit alpha-1	0.210204654	0.142810956	0.214591294	0.963258031	0.176507805	0.5889246625	0.176507805	0.5889246625	0.299712028106821	0.062138	0	3.33653609538683	0.062383	0	GO:0099738,cell cortex region;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005834,heterotrimeric G-protein complex;GO:0005765,lysosomal membrane;GO:0045121,membrane raft;GO:0030496,midbody;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0001664,G protein-coupled receptor binding;GO:0031821,G protein-coupled serotonin receptor binding;GO:0031683,G-protein beta/gamma-subunit complex binding;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0032794,GTPase activating protein binding;GO:0003924,GTPase activity;GO:0000287,magnesium ion binding;GO:0019001,guanyl nucleotide binding	GO:0007193,adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007188,adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007049,cell cycle;GO:0051301,cell division;GO:1904322,cellular response to forskolin;GO:0007186,G protein-coupled receptor signaling pathway;GO:0050805,negative regulation of synaptic transmission;GO:0030168,platelet activation;GO:1904778,positive regulation of protein localization to cell cortex;GO:0006457,protein folding;GO:0043949,regulation of cAMP-mediated signaling;GO:0060236,regulation of mitotic spindle organization;GO:0043434,response to peptide hormone	hsa:2770,path:hsa04015,Rap1 signaling pathway;hsa:2770,path:hsa04371,Apelin signaling pathway;hsa:2770,path:hsa04071,Sphingolipid signaling pathway;hsa:2770,path:hsa04024,cAMP signaling pathway;hsa:2770,path:hsa04022,cGMP-PKG signaling pathway;hsa:2770,path:hsa04540,Gap junction;hsa:2770,path:hsa04611,Platelet activation;hsa:2770,path:hsa04670,Leukocyte transendothelial migration;hsa:2770,path:hsa04062,Chemokine signaling pathway;hsa:2770,path:hsa04923,Regulation of lipolysis in adipocytes;hsa:2770,path:hsa04915,Estrogen signaling pathway;hsa:2770,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:2770,path:hsa04921,Oxytocin signaling pathway;hsa:2770,path:hsa04926,Relaxin signaling pathway;hsa:2770,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:2770,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:2770,path:hsa04916,Melanogenesis;hsa:2770,path:hsa04924,Renin secretion;hsa:2770,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:2770,path:hsa04971,Gastric acid secretion;hsa:2770,path:hsa04724,Glutamatergic synapse;hsa:2770,path:hsa04727,GABAergic synapse;hsa:2770,path:hsa04725,Cholinergic synapse;hsa:2770,path:hsa04728,Dopaminergic synapse;hsa:2770,path:hsa04726,Serotonergic synapse;hsa:2770,path:hsa04730,Long-term depression;hsa:2770,path:hsa04723,Retrograde endocannabinoid signaling;hsa:2770,path:hsa04360,Axon guidance;hsa:2770,path:hsa04713,Circadian entrainment;hsa:2770,path:hsa05200,Pathways in cancer;hsa:2770,path:hsa05012,Parkinson disease;hsa:2770,path:hsa05030,Cocaine addiction;hsa:2770,path:hsa05032,Morphine addiction;hsa:2770,path:hsa05034,Alcoholism;hsa:2770,path:hsa04934,Cushing syndrome;hsa:2770,path:hsa05133,Pertussis;hsa:2770,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:2770,path:hsa05163,Human cytomegalovirus infection;hsa:2770,path:hsa05145,Toxoplasmosis;hsa:2770,path:hsa05142,Chagas disease (American trypanosomiasis)
ACE_HUMAN	P12821	ACE	Angiotensin-converting enzyme	0.115168727	0.215399532	0.382281867	1.307537464	0.1652841295	0.8449096655	0.1652841295	0.8449096655	0.195623433189379	0.014297	-1	5.1118620284714	0.014397	1	GO:0005768,endosome;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0016021,integral component of membrane;GO:0005764,lysosome;GO:0005886,plasma membrane;GO:0016020,membrane	GO:0003779,actin binding;GO:0031711,bradykinin receptor binding;GO:0004180,carboxypeptidase activity;GO:0031404,chloride ion binding;GO:0004175,endopeptidase activity;GO:0008238,exopeptidase activity;GO:0070573,metallodipeptidase activity;GO:0008237,metallopeptidase activity;GO:0051019,mitogen-activated protein kinase binding;GO:0031434,mitogen-activated protein kinase kinase binding;GO:0008241,peptidyl-dipeptidase activity;GO:0008240,tripeptidyl-peptidase activity;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0050435,amyloid-beta metabolic process;GO:0002003,angiotensin maturation;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0050482,arachidonic acid secretion;GO:0097746,blood vessel diameter maintenance;GO:0001974,blood vessel remodeling;GO:0071838,cell proliferation in bone marrow;GO:0060047,heart contraction;GO:0060218,hematopoietic stem cell differentiation;GO:0042447,hormone catabolic process;GO:0001822,kidney development;GO:0032943,mononuclear cell proliferation;GO:1903597,negative regulation of gap junction assembly;GO:0010629,negative regulation of gene expression;GO:0032091,negative regulation of protein binding;GO:0002446,neutrophil mediated immunity;GO:0043171,peptide catabolic process;GO:2000170,positive regulation of peptidyl-cysteine S-nitrosylation;GO:1900086,positive regulation of peptidyl-tyrosine autophosphorylation;GO:0032092,positive regulation of protein binding;GO:0061098,positive regulation of protein tyrosine kinase activity;GO:0003084,positive regulation of systemic arterial blood pressure;GO:0010608,posttranscriptional regulation of gene expression;GO:0006508,proteolysis;GO:0060177,regulation of angiotensin metabolic process;GO:0008217,regulation of blood pressure;GO:1902033,regulation of hematopoietic stem cell proliferation;GO:0002019,regulation of renal output by angiotensin;GO:0014910,regulation of smooth muscle cell migration;GO:0003081,regulation of systemic arterial blood pressure by renin-angiotensin;GO:0019229,regulation of vasoconstriction;GO:0007283,spermatogenesis	hsa:1636,path:hsa04924,Renin secretion;hsa:1636,path:hsa04614,Renin-angiotensin system;hsa:1636,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:1636,path:hsa05142,Chagas disease (American trypanosomiasis)
STML2_HUMAN	Q9UJZ1	STOML2	Stomatin-like protein 2, mitochondrial	1.441969006	0.488726512	1.455036143	0.887111467	0.965347759	1.171073805	0.965347759	1.171073805	0.824327002173872	0.497998	0	1.21311081326082	0.497944	0	GO:0005856,cytoskeleton;GO:0019897,extrinsic component of plasma membrane;GO:0045121,membrane raft;GO:0005743,mitochondrial inner membrane;GO:0005758,mitochondrial intermembrane space;GO:0005886,plasma membrane	GO:1901612,cardiolipin binding;GO:0051020,GTPase binding;GO:0005102,signaling receptor binding	GO:0035710,CD4-positive, alpha-beta T cell activation;GO:0006874,cellular calcium ion homeostasis;GO:0010876,lipid localization;GO:0042776,mitochondrial ATP synthesis coupled proton transport;GO:0006851,mitochondrial calcium ion transmembrane transport;GO:0034982,mitochondrial protein processing;GO:0007005,mitochondrion organization;GO:1900210,positive regulation of cardiolipin metabolic process;GO:0032743,positive regulation of interleukin-2 production;GO:0090297,positive regulation of mitochondrial DNA replication;GO:0010918,positive regulation of mitochondrial membrane potential;GO:0051259,protein complex oligomerization;GO:1990046,stress-induced mitochondrial fusion;GO:0050852,T cell receptor signaling pathway	
TRA2B_HUMAN	P62995	TRA2B	Transformer-2 protein homolog beta	0.681267725	1.040898377	1.718373132	0.354031698	0.861083051	1.036202415	0.861083051	1.036202415	0.830998884518137	0.495288	0	1.20337104974558	0.495227	0	GO:0005637,nuclear inner membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0032991,protein-containing complex;GO:0005681,spliceosomal complex	GO:0042802,identical protein binding;GO:0003729,mRNA binding;GO:0036002,pre-mRNA binding;GO:0019904,protein domain specific binding;GO:0003723,RNA binding	GO:0071333,cellular response to glucose stimulus;GO:0021796,cerebral cortex regionalization;GO:1990403,embryonic brain development;GO:0000398,mRNA splicing, via spliceosome;GO:0048026,positive regulation of mRNA splicing, via spliceosome;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0043484,regulation of RNA splicing;GO:0000302,response to reactive oxygen species;GO:0000375,RNA splicing, via transesterification reactions	hsa:6434,path:hsa03040,Spliceosome
TNIP2_HUMAN	Q8NFZ5	TNIP2	TNFAIP3-interacting protein 2	0.531545663	0.559854778	0.271780219	1.077742785	0.5457002205	0.674761502	0.5457002205	0.674761502	0.808730520165331	0.491984	0	1.2365058261874	0.492084	0	GO:0005829,cytosol;GO:0005654,nucleoplasm	GO:0070530,K63-linked polyubiquitin modification-dependent protein binding;GO:0046872,metal ion binding;GO:0031593,polyubiquitin modification-dependent protein binding;GO:0019901,protein kinase binding	GO:0006915,apoptotic process;GO:0023035,CD40 signaling pathway;GO:0071222,cellular response to lipopolysaccharide;GO:0006954,inflammatory response;GO:0070498,interleukin-1-mediated signaling pathway;GO:2000352,negative regulation of endothelial cell apoptotic process;GO:0050871,positive regulation of B cell activation;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043032,positive regulation of macrophage activation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0016579,protein deubiquitination;GO:0050821,protein stabilization;GO:0051403,stress-activated MAPK cascade;GO:0034134,toll-like receptor 2 signaling pathway;GO:0034138,toll-like receptor 3 signaling pathway;GO:0034162,toll-like receptor 9 signaling pathway	
TCOF_HUMAN	Q13428	TCOF1	Treacle protein	0.664107281	0.166290275	0.520641644	3.885688562	0.415198778	2.203165103	0.415198778	2.203165103	0.188455589385758	0.012349	-1	5.30628995011156	0.012439	1	GO:0005829,cytosol;GO:0001650,fibrillar center;GO:0005730,nucleolus;GO:0005654,nucleoplasm	GO:0046982,protein heterodimerization activity;GO:0030674,protein-macromolecule adaptor activity;GO:0003723,RNA binding;GO:0097110,scaffold protein binding;GO:0005215,transporter activity	GO:0014032,neural crest cell development;GO:0014029,neural crest formation;GO:0042790,nucleolar large rRNA transcription by RNA polymerase I;GO:0006417,regulation of translation;GO:0001501,skeletal system development	hsa:6949,path:hsa03008,Ribosome biogenesis in eukaryotes
UAP1L_HUMAN	Q3KQV9	UAP1L1	UDP-N-acetylhexosamine pyrophosphorylase-like protein 1	0.129015062	0.126712242	0.27532374	0.173320948	0.127863652	0.224322344	0.127863652	0.224322344	0.569999625182233	0.289547	0	1.75438711855344	0.289842	0		GO:0003977,UDP-N-acetylglucosamine diphosphorylase activity	GO:0006048,UDP-N-acetylglucosamine biosynthetic process	hsa:91373,path:hsa00520,Amino sugar and nucleotide sugar metabolism
DLDH_HUMAN	P09622	DLD	Dihydrolipoyl dehydrogenase, mitochondrial	4.814061617	2.905676432	5.548077192	5.466838884	3.8598690245	5.507458038	3.8598690245	5.507458038	0.700844018759276	0.405590	0	1.4268510156801	0.405784	0	GO:0043159,acrosomal matrix;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0031514,motile cilium;GO:0005634,nucleus;GO:0045252,oxoglutarate dehydrogenase complex;GO:0045254,pyruvate dehydrogenase complex;GO:0001669,acrosomal vesicle	GO:0004148,dihydrolipoyl dehydrogenase activity;GO:0050660,flavin adenine dinucleotide binding;GO:0043544,lipoamide binding;GO:0051287,NAD binding;GO:0016668,oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	GO:0006103,2-oxoglutarate metabolic process;GO:0007568,aging;GO:0009083,branched-chain amino acid catabolic process;GO:0045454,cell redox homeostasis;GO:0051068,dihydrolipoamide metabolic process;GO:0007369,gastrulation;GO:0006546,glycine catabolic process;GO:0106077,histone succinylation;GO:0009106,lipoate metabolic process;GO:0006554,lysine catabolic process;GO:0061732,mitochondrial acetyl-CoA biosynthetic process from pyruvate;GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0006508,proteolysis;GO:0006090,pyruvate metabolic process;GO:0042391,regulation of membrane potential;GO:0048240,sperm capacitation;GO:0006099,tricarboxylic acid cycle	hsa:1738,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:1738,path:hsa00020,Citrate cycle (TCA cycle);hsa:1738,path:hsa00620,Pyruvate metabolism;hsa:1738,path:hsa00630,Glyoxylate and dicarboxylate metabolism;hsa:1738,path:hsa00640,Propanoate metabolism;hsa:1738,path:hsa00260,Glycine, serine and threonine metabolism;hsa:1738,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:1738,path:hsa00310,Lysine degradation;hsa:1738,path:hsa00380,Tryptophan metabolism
SRSF2_HUMAN	Q01130	SRSF2	Serine/arginine-rich splicing factor 2	101.6335139	3.957349962	3.239707766	554.0336252	52.795431931	278.636666483	52.795431931	278.636666483	0.18947769005922	0.012616	-1	5.27766619746873	0.012708	1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003723,RNA binding;GO:0003714,transcription corepressor activity	GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0006405,RNA export from nucleus;GO:0008380,RNA splicing	hsa:6427,path:hsa03040,Spliceosome;hsa:6427,path:hsa05168,Herpes simplex virus 1 infection
CLCA_HUMAN	P09496	CLTA	Clathrin light chain A	1.419366512	1.867733128	1.024227894	0.179740666	1.64354982	0.60198428	1.64354982	0.60198428	2.73022049678772	0.155195	0	0.36627078332192	0.154625	0	GO:0030118,clathrin coat;GO:0030132,clathrin coat of coated pit;GO:0030130,clathrin coat of trans-Golgi network vesicle;GO:0071439,clathrin complex;GO:0030125,clathrin vesicle coat;GO:0045334,clathrin-coated endocytic vesicle;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0036020,endolysosome membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0099631,postsynaptic endocytic zone cytoplasmic component;GO:0098835,presynaptic endocytic zone membrane;GO:0005819,spindle;GO:0030672,synaptic vesicle membrane;GO:0032588,trans-Golgi network membrane	GO:0032050,clathrin heavy chain binding;GO:0051020,GTPase binding;GO:0042277,peptide binding;GO:0044877,protein-containing complex binding;GO:0005198,structural molecule activity	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0007049,cell cycle;GO:0051301,cell division;GO:0048268,clathrin coat assembly;GO:0072583,clathrin-dependent endocytosis;GO:0006886,intracellular protein transport;GO:0034383,low-density lipoprotein particle clearance;GO:0032802,low-density lipoprotein particle receptor catabolic process;GO:0061024,membrane organization;GO:0006892,post-Golgi vesicle-mediated transport;GO:0016192,vesicle-mediated transport	hsa:1211,path:hsa04144,Endocytosis;hsa:1211,path:hsa04142,Lysosome;hsa:1211,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:1211,path:hsa04721,Synaptic vesicle cycle;hsa:1211,path:hsa05016,Huntington disease;hsa:1211,path:hsa05100,Bacterial invasion of epithelial cells
PSMD5_HUMAN	Q16401	PSMD5	26S proteasome non-ATPase regulatory subunit 5	2.198847149	0.942378953	3.21890794	1.7776643	1.570613051	2.49828612	1.570613051	2.49828612	0.628676210633552	0.342748	0	1.59064393257738	0.343003	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0022624,proteasome accessory complex;GO:0000502,proteasome complex		GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0070682,proteasome regulatory particle assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0043248,proteasome assembly	
PLBL2_HUMAN	Q8NHP8	PLBD2	Putative phospholipase B-like 2	0.363383847	0.569548725	0.840909858	1.038581069	0.466466286	0.9397454635	0.466466286	0.9397454635	0.496375139990234	0.221818	0	2.01460532455287	0.222148	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0043202,lysosomal lumen	GO:0004620,phospholipase activity	GO:0009395,phospholipid catabolic process	
UFM1_HUMAN	P61960	UFM1	Ubiquitin-fold modifier 1	0.199539896	0.193949627	0.263454493	0.186898933	0.1967447615	0.225176713	0.1967447615	0.225176713	0.873734938568004	0.478436	0	1.14451186035772	0.478337	0	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005634,nucleus		GO:0007420,brain development;GO:0043066,negative regulation of apoptotic process;GO:0042308,negative regulation of protein import into nucleus;GO:1990592,protein K69-linked ufmylation;GO:0071569,protein ufmylation;GO:0033146,regulation of intracellular estrogen receptor signaling pathway;GO:0034976,response to endoplasmic reticulum stress;GO:0061709,reticulophagy	
AIP_HUMAN	O00170	AIP	AH receptor-interacting protein	0.532944369	0.852030173	0.625562107	0.510217198	0.692487271	0.5678896525	0.692487271	0.5678896525	1.21940462896531	0.368797	0	0.820072333863881	0.368467	0	GO:0034751,aryl hydrocarbon receptor complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005654,nucleoplasm	GO:0017162,aryl hydrocarbon receptor binding;GO:0036004,GAF domain binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity;GO:0003713,transcription coactivator activity;GO:0008134,transcription factor binding;GO:0051082,unfolded protein binding	GO:0035722,interleukin-12-mediated signaling pathway;GO:0051344,negative regulation of cyclic-nucleotide phosphodiesterase activity;GO:0022417,protein maturation by protein folding;GO:0006626,protein targeting to mitochondrion;GO:0010738,regulation of protein kinase A signaling;GO:0006805,xenobiotic metabolic process	hsa:9049,path:hsa04934,Cushing syndrome
FNTA_HUMAN	P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	0.207024599	0.176927139	0.265247624	0.348036873	0.191975869	0.3066422485	0.191975869	0.3066422485	0.626058118015659	0.340407	0	1.59729579606695	0.340664	0	GO:0005953,CAAX-protein geranylgeranyltransferase complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005875,microtubule associated complex;GO:0005886,plasma membrane;GO:0005965,protein farnesyltransferase complex	GO:0030548,acetylcholine receptor regulator activity;GO:0043014,alpha-tubulin binding;GO:0004662,CAAX-protein geranylgeranyltransferase activity;GO:0008017,microtubule binding;GO:0004660,protein farnesyltransferase activity;GO:0004661,protein geranylgeranyltransferase activity;GO:0004663,Rab geranylgeranyltransferase activity;GO:0030971,receptor tyrosine kinase binding;GO:0008318,protein prenyltransferase activity	GO:0000165,MAPK cascade;GO:0045213,neurotransmitter receptor metabolic process;GO:0090045,positive regulation of deacetylase activity;GO:0090044,positive regulation of tubulin deacetylation;GO:0018343,protein farnesylation;GO:0018344,protein geranylgeranylation;GO:0022400,regulation of rhodopsin mediated signaling pathway;GO:0071340,skeletal muscle acetylcholine-gated channel clustering;GO:0007179,transforming growth factor beta receptor signaling pathway;GO:0018342,protein prenylation	hsa:2339,path:hsa00900,Terpenoid backbone biosynthesis
SC11A_HUMAN	P67812	SEC11A	Signal peptidase complex catalytic subunit SEC11A	2.047734497	8.725245072	0.503377094	0.143198105	5.3864897845	0.3232875995	5.3864897845	0.3232875995	16.6616034541096	0.005560	1	0.0600182331042904	0.005468	-1	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0005787,signal peptidase complex	GO:0008233,peptidase activity;GO:0004252,serine-type endopeptidase activity	GO:0006465,signal peptide processing	hsa:23478,path:hsa03060,Protein export
ELAV1_HUMAN	Q15717	ELAVL1	ELAV-like protein 1	2.795625578	11.35253226	2.93168162	1.451317017	7.074078919	2.1914993185	7.074078919	2.1914993185	3.22796309324976	0.123931	0	0.309792885207138	0.123378	0	GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0098978,glutamatergic synapse;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0098794,postsynapse;GO:1990904,ribonucleoprotein complex	GO:0003725,double-stranded RNA binding;GO:0035198,miRNA binding;GO:0035925,mRNA 3'-UTR AU-rich region binding;GO:0003730,mRNA 3'-UTR binding;GO:0003729,mRNA binding;GO:0042803,protein homodimerization activity;GO:0019901,protein kinase binding;GO:0003723,RNA binding	GO:0070935,3'-UTR-mediated mRNA stabilization;GO:0000398,mRNA splicing, via spliceosome;GO:0048255,mRNA stabilization;GO:0060965,negative regulation of gene silencing by miRNA;GO:0045727,positive regulation of translation;GO:0016441,posttranscriptional gene silencing;GO:0051260,protein homooligomerization;GO:0006606,protein import into nucleus;GO:0043488,regulation of mRNA stability;GO:2000036,regulation of stem cell population maintenance	hsa:1994,path:hsa04152,AMPK signaling pathway;hsa:1994,path:hsa04657,IL-17 signaling pathway
RS28_HUMAN	P62857	RPS28	40S ribosomal protein S28	0.95638753	0.891670007	1.112360234	0.605413816	0.9240287685	0.858887025	0.9240287685	0.858887025	1.07584436788994	0.409253	0	0.92950247251961	0.409005	0	GO:0098556,cytoplasmic side of rough endoplasmic reticulum membrane;GO:0005829,cytosol;GO:0022627,cytosolic small ribosomal subunit;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0042788,polysomal ribosome;GO:0015935,small ribosomal subunit	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0030490,maturation of SSU-rRNA;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000028,ribosomal small subunit assembly;GO:0042274,ribosomal small subunit biogenesis;GO:0042254,ribosome biogenesis;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6234,path:hsa03010,Ribosome
MFAP2_HUMAN	P55001	MFAP2	Microfibrillar-associated protein 2	1.311736262	5.90345801	0.066997897	0.375015103	3.607597136	0.2210065	3.607597136	0.2210065	16.3234888385636	0.005841	1	0.0612614135305157	0.005746	-1	GO:0062023,collagen-containing extracellular matrix;GO:0005576,extracellular region;GO:0001527,microfibril		GO:0048048,embryonic eye morphogenesis;GO:0030198,extracellular matrix organization;GO:0120162,positive regulation of cold-induced thermogenesis;GO:0048050,post-embryonic eye morphogenesis	
CO6A1_HUMAN	P12109	COL6A1	Collagen alpha-1(VI) chain	34.97635313	44.69687098	46.66234203	471.1937502	39.836612055	258.928046115	39.836612055	258.928046115	0.153852055243591	0.005292	-1	6.49975067552215	0.005341	1	GO:0005589,collagen type VI trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0032991,protein-containing complex;GO:0042383,sarcolemma	GO:0005518,collagen binding;GO:0030020,extracellular matrix structural constituent conferring tensile strength;GO:0048407,platelet-derived growth factor binding	GO:0007155,cell adhesion;GO:0071230,cellular response to amino acid stimulus;GO:0030199,collagen fibril organization;GO:0035987,endodermal cell differentiation;GO:0030198,extracellular matrix organization;GO:0001649,osteoblast differentiation	hsa:1291,path:hsa04151,PI3K-Akt signaling pathway;hsa:1291,path:hsa04512,ECM-receptor interaction;hsa:1291,path:hsa04510,Focal adhesion;hsa:1291,path:hsa04974,Protein digestion and absorption;hsa:1291,path:hsa05165,Human papillomavirus infection
ESYT2_HUMAN	A0FGR8	ESYT2	Extended synaptotagmin-2	1.648811657	1.741174264	2.69794856	10.73714492	1.6949929605	6.71754674	1.6949929605	6.71754674	0.252323210556478	0.035923	-1	3.96317087831351	0.036105	1	GO:0005789,endoplasmic reticulum membrane;GO:0140268,endoplasmic reticulum-plasma membrane contact site;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0005887,integral component of plasma membrane;GO:0031227,intrinsic component of endoplasmic reticulum membrane;GO:0016020,membrane;GO:0044232,organelle membrane contact site;GO:0016021,integral component of membrane;GO:0005886,plasma membrane	GO:0045296,cadherin binding;GO:0005509,calcium ion binding;GO:0005544,calcium-dependent phospholipid binding;GO:0042802,identical protein binding;GO:0031210,phosphatidylcholine binding;GO:0008429,phosphatidylethanolamine binding;GO:0035091,phosphatidylinositol binding;GO:0008289,lipid binding	GO:0006897,endocytosis;GO:0061817,endoplasmic reticulum-plasma membrane tethering;GO:0006687,glycosphingolipid metabolic process;GO:0006869,lipid transport	
K2C5_HUMAN	P13647	KRT5	Keratin, type II cytoskeletal 5	161.8923563	185.5204152	173.2648469	131.7542205	173.70638575	152.5095337	173.70638575	152.5095337	1.13898706222325	0.390683	0	0.877973098349379	0.390397	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005882,intermediate filament;GO:0045095,keratin filament;GO:0016020,membrane;GO:0005634,nucleus	GO:0097110,scaffold protein binding;GO:0005200,structural constituent of cytoskeleton	GO:0070268,cornification;GO:0008544,epidermis development;GO:0031581,hemidesmosome assembly;GO:0031424,keratinization	
TPSNR_HUMAN	Q9BX59	TAPBPL	Tapasin-related protein	0.127458011	0.143541587	0.090133348	0.070640511	0.135499799	0.0803869295	0.135499799	0.0803869295	1.68559490756517	0.271619	0	0.593262352367032	0.271128	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0005886,plasma membrane	GO:0023024,MHC class I protein complex binding	GO:0002590,negative regulation of antigen processing and presentation of peptide antigen via MHC class I;GO:0002502,peptide antigen assembly with MHC class I protein complex	
NAA50_HUMAN	Q9GZZ1	NAA50	N-alpha-acetyltransferase 50	1.007703729	0.600000297	0.093528274	0.001970098	0.803852013	0.047749186	0.803852013	0.047749186	16.8348841171868	0.005423	1	0.0594004682799743	0.005333	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0031415,NatA complex;GO:0005634,nucleus	GO:0010485,H4 histone acetyltransferase activity;GO:0008080,N-acetyltransferase activity;GO:0004596,peptide alpha-N-acetyltransferase activity;GO:0052858,peptidyl-lysine acetyltransferase activity	GO:0034087,establishment of mitotic sister chromatid cohesion;GO:0016573,histone acetylation;GO:0007064,mitotic sister chromatid cohesion;GO:0071962,mitotic sister chromatid cohesion, centromeric;GO:0006474,N-terminal protein amino acid acetylation	
IQGA1_HUMAN	P46940	IQGAP1	Ras GTPase-activating-like protein IQGAP1	37.4289317	32.25249443	48.36320162	79.43078908	34.840713065	63.89699535	34.840713065	63.89699535	0.545263715048849	0.266803	0	1.83397496000704	0.267113	0	GO:0005884,actin filament;GO:0030424,axon;GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0005925,focal adhesion;GO:0030426,growth cone;GO:0045121,membrane raft;GO:0005874,microtubule;GO:0030496,midbody;GO:0043005,neuron projection;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0001726,ruffle;GO:0030667,secretory granule membrane;GO:0036057,slit diaphragm	GO:0051015,actin filament binding;GO:0045296,cadherin binding;GO:0005509,calcium ion binding;GO:0005516,calmodulin binding;GO:0005096,GTPase activator activity;GO:0005095,GTPase inhibitor activity;GO:0005078,MAP-kinase scaffold activity;GO:0051019,mitogen-activated protein kinase binding;GO:0060090,molecular adaptor activity;GO:0005547,phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019904,protein domain specific binding;GO:0019901,protein kinase binding;GO:0019903,protein phosphatase binding;GO:0043539,protein serine/threonine kinase activator activity;GO:0044548,S100 protein binding;GO:0031267,small GTPase binding	GO:0016477,cell migration;GO:0071277,cellular response to calcium ion;GO:0071364,cellular response to epidermal growth factor stimulus;GO:0007173,epidermal growth factor receptor signaling pathway;GO:0072015,glomerular visceral epithelial cell development;GO:1990138,neuron projection extension;GO:0043312,neutrophil degranulation;GO:1903829,positive regulation of cellular protein localization;GO:1900006,positive regulation of dendrite development;GO:0051894,positive regulation of focal adhesion assembly;GO:0043406,positive regulation of MAP kinase activity;GO:0043410,positive regulation of MAPK cascade;GO:1900086,positive regulation of peptidyl-tyrosine autophosphorylation;GO:0045860,positive regulation of protein kinase activity;GO:1904754,positive regulation of vascular associated smooth muscle cell migration;GO:0032956,regulation of actin cytoskeleton organization;GO:0007346,regulation of mitotic cell cycle;GO:1990776,response to angiotensin;GO:0007165,signal transduction;GO:0016032,viral process;GO:0043087,regulation of GTPase activity	hsa:8826,path:hsa04520,Adherens junction;hsa:8826,path:hsa04810,Regulation of actin cytoskeleton;hsa:8826,path:hsa05205,Proteoglycans in cancer
PSPC_HUMAN	P11686	SFTPC	Pulmonary surfactant-associated protein C	0.179299318	0.893882098	0.10547633	0.24020674	0.536590708	0.172841535	0.536590708	0.172841535	3.1045240832882	0.130784	0	0.322110562898529	0.130225	0	GO:0097208,alveolar lamellar body;GO:0045334,clathrin-coated endocytic vesicle;GO:0005789,endoplasmic reticulum membrane;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0042599,lamellar body;GO:0097486,multivesicular body lumen;GO:0016021,integral component of membrane	GO:0042802,identical protein binding	GO:0044267,cellular protein metabolic process;GO:0007585,respiratory gaseous exchange by respiratory system	
NIT2_HUMAN	Q9NQR4	NIT2	Omega-amidase NIT2	0.52908804	3.21057085	0.483039699	0.611505825	1.869829445	0.547272762	1.869829445	0.547272762	3.41663165944298	0.114404	0	0.292685925694148	0.113861	0	GO:0005813,centrosome;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen	GO:0106008,2-oxoglutaramate amidase activity;GO:0050152,omega-amidase activity	GO:0006528,asparagine metabolic process;GO:0006541,glutamine metabolic process;GO:0043312,neutrophil degranulation;GO:0006107,oxaloacetate metabolic process;GO:0006807,nitrogen compound metabolic process	hsa:56954,path:hsa00250,Alanine, aspartate and glutamate metabolism
IDH3A_HUMAN	P50213	IDH3A	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	2.902863001	1.085351268	4.270836015	1.485112688	1.9941071345	2.8779743515	1.9941071345	2.8779743515	0.692885651833788	0.398838	0	1.44323958412677	0.399039	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0004449,isocitrate dehydrogenase (NAD+) activity;GO:0000287,magnesium ion binding;GO:0051287,NAD binding;GO:0016616,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO:0005975,carbohydrate metabolic process;GO:0006102,isocitrate metabolic process;GO:0006099,tricarboxylic acid cycle	hsa:3419,path:hsa00020,Citrate cycle (TCA cycle)
APOB_HUMAN	P04114	APOB	Apolipoprotein B-100	7.44743301	5.492223906	17.96629402	88.40070385	6.469828458	53.183498935	6.469828458	53.183498935	0.121651049433722	0.001778	-1	8.2202332380603	0.001799	1	GO:0042627,chylomicron;GO:0034360,chylomicron remnant;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005769,early endosome;GO:0071682,endocytic vesicle lumen;GO:0070971,endoplasmic reticulum exit site;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0031904,endosome lumen;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0034364,high-density lipoprotein particle;GO:0034363,intermediate-density lipoprotein particle;GO:0043231,intracellular membrane-bounded organelle;GO:0005811,lipid droplet;GO:0034362,low-density lipoprotein particle;GO:0043202,lysosomal lumen;GO:0034359,mature chylomicron;GO:0043025,neuronal cell body;GO:0005886,plasma membrane;GO:0005790,smooth endoplasmic reticulum;GO:0034361,very-low-density lipoprotein particle;GO:0031983,vesicle lumen	GO:0120020,cholesterol transfer activity;GO:0008201,heparin binding;GO:0035473,lipase binding;GO:0050750,low-density lipoprotein particle receptor binding;GO:0005543,phospholipid binding;GO:0005319,lipid transporter activity	GO:0048844,artery morphogenesis;GO:0044267,cellular protein metabolic process;GO:0071379,cellular response to prostaglandin stimulus;GO:0071356,cellular response to tumor necrosis factor;GO:0033344,cholesterol efflux;GO:0042632,cholesterol homeostasis;GO:0008203,cholesterol metabolic process;GO:0030301,cholesterol transport;GO:0034378,chylomicron assembly;GO:0034382,chylomicron remnant clearance;GO:0034371,chylomicron remodeling;GO:0009566,fertilization;GO:0030317,flagellated sperm motility;GO:0001701,in utero embryonic development;GO:0050900,leukocyte migration;GO:0042158,lipoprotein biosynthetic process;GO:0042159,lipoprotein catabolic process;GO:0042953,lipoprotein transport;GO:0034383,low-density lipoprotein particle clearance;GO:0034374,low-density lipoprotein particle remodeling;GO:0061024,membrane organization;GO:0007399,nervous system development;GO:0010886,positive regulation of cholesterol storage;GO:0010628,positive regulation of gene expression;GO:0010884,positive regulation of lipid storage;GO:0010744,positive regulation of macrophage derived foam cell differentiation;GO:0009791,post-embryonic development;GO:0043687,post-translational protein modification;GO:0006898,receptor-mediated endocytosis;GO:0045540,regulation of cholesterol biosynthetic process;GO:0009743,response to carbohydrate;GO:0032355,response to estradiol;GO:0032496,response to lipopolysaccharide;GO:0010269,response to selenium ion;GO:0009615,response to virus;GO:0001523,retinoid metabolic process;GO:0007283,spermatogenesis;GO:0002224,toll-like receptor signaling pathway;GO:0019433,triglyceride catabolic process;GO:0006642,triglyceride mobilization;GO:0034379,very-low-density lipoprotein particle assembly;GO:0034447,very-low-density lipoprotein particle clearance	hsa:338,path:hsa04975,Fat digestion and absorption;hsa:338,path:hsa04979,Cholesterol metabolism;hsa:338,path:hsa04977,Vitamin digestion and absorption
2ABA_HUMAN	P63151	PPP2R2A	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	0.998657917	0.409009112	1.196270886	1.028964409	0.7038335145	1.1126176475	0.7038335145	1.1126176475	0.632592441870288	0.346243	0	1.58079662956999	0.346494	0	GO:0005829,cytosol;GO:0098978,glutamatergic synapse;GO:0005654,nucleoplasm;GO:0000159,protein phosphatase type 2A complex	GO:0051721,protein phosphatase 2A binding;GO:0019888,protein phosphatase regulator activity;GO:0044877,protein-containing complex binding;GO:0048156,tau protein binding	GO:0000086,G2/M transition of mitotic cell cycle;GO:0007084,mitotic nuclear envelope reassembly;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0070262,peptidyl-serine dephosphorylation;GO:0006470,protein dephosphorylation;GO:0043278,response to morphine	hsa:5520,path:hsa03015,mRNA surveillance pathway;hsa:5520,path:hsa04390,Hippo signaling pathway;hsa:5520,path:hsa04071,Sphingolipid signaling pathway;hsa:5520,path:hsa04151,PI3K-Akt signaling pathway;hsa:5520,path:hsa04152,AMPK signaling pathway;hsa:5520,path:hsa04530,Tight junction;hsa:5520,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:5520,path:hsa04728,Dopaminergic synapse;hsa:5520,path:hsa05160,Hepatitis C;hsa:5520,path:hsa05165,Human papillomavirus infection;hsa:5520,path:hsa05142,Chagas disease (American trypanosomiasis)
AFAM_HUMAN	P43652	AFM	Afamin	0.465565549	0.486904877	0.753164477	3.236369916	0.476235213	1.9947671965	0.476235213	1.9947671965	0.238742252146315	0.029739	-1	4.18861760333543	0.029901	1	GO:0072562,blood microparticle;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0005504,fatty acid binding;GO:0008431,vitamin E binding;GO:0008270,zinc ion binding	GO:0050821,protein stabilization;GO:0071693,protein transport within extracellular region;GO:0051180,vitamin transport	
KTN1_HUMAN	Q86UP2	KTN1	Kinectin	6.560620331	6.026983491	7.046772554	15.87513871	6.293801911	11.460955632	6.293801911	11.460955632	0.549151581516218	0.270384	0	1.82099084052345	0.270692	0	GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0016020,membrane	GO:0045296,cadherin binding;GO:0019894,kinesin binding;GO:0003723,RNA binding	GO:0044267,cellular protein metabolic process;GO:0007018,microtubule-based movement;GO:0043687,post-translational protein modification;GO:0015031,protein transport	
LMF2_HUMAN	Q9BU23	LMF2	Lipase maturation factor 2	0.062273769	0.095955255	0.269291594	0.055464743	0.079114512	0.1623781685	0.079114512	0.1623781685	0.487223822825665	0.213451	0	2.05244479672705	0.213783	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane		GO:0051604,protein maturation	
ACO13_HUMAN	Q9NPJ3	ACOT13	Acyl-coenzyme A thioesterase 13	0.804896697	1.969376966	1.599982943	0.086635097	1.3871368315	0.84330902	1.3871368315	0.84330902	1.64487370418497	0.278497	0	0.607949411225766	0.278015	0	GO:0005829,cytosol;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005819,spindle	GO:0047617,acyl-CoA hydrolase activity;GO:0046872,metal ion binding;GO:0102991,myristoyl-CoA hydrolase activity;GO:0016290,palmitoyl-CoA hydrolase activity	GO:0006637,acyl-CoA metabolic process;GO:0120163,negative regulation of cold-induced thermogenesis;GO:0051289,protein homotetramerization	
VATD_HUMAN	Q9Y5K8	ATP6V1D	V-type proton ATPase subunit D	0.216923196	0.100016682	0.080612128	0.139029899	0.158469939	0.1098210135	0.158469939	0.1098210135	1.44298376011618	0.316703	0	0.69300849229203	0.316279	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0033176,proton-transporting V-type ATPase complex;GO:0035579,specific granule membrane	GO:0046961,proton-transporting ATPase activity, rotational mechanism;GO:0042626,ATPase-coupled transmembrane transporter activity	GO:0034198,cellular response to amino acid starvation;GO:0060271,cilium assembly;GO:0008286,insulin receptor signaling pathway;GO:0034220,ion transmembrane transport;GO:0043312,neutrophil degranulation;GO:0090383,phagosome acidification;GO:0061512,protein localization to cilium;GO:0016241,regulation of macroautophagy;GO:0033572,transferrin transport;GO:0030030,cell projection organization;GO:0006811,ion transport	hsa:51382,path:hsa00190,Oxidative phosphorylation;hsa:51382,path:hsa04150,mTOR signaling pathway;hsa:51382,path:hsa04145,Phagosome;hsa:51382,path:hsa04966,Collecting duct acid secretion;hsa:51382,path:hsa04721,Synaptic vesicle cycle;hsa:51382,path:hsa05323,Rheumatoid arthritis;hsa:51382,path:hsa05110,Vibrio cholerae infection;hsa:51382,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:51382,path:hsa05165,Human papillomavirus infection
TEX10_HUMAN	Q9NXF1	TEX10	Testis-expressed protein 10	0.051945745	0.037470751	0.131537655	0.104070305	0.044708248	0.11780398	0.044708248	0.11780398	0.379513900973465	0.119737	0	2.6349495958777	0.120053	0	GO:0005739,mitochondrion;GO:0071339,MLL1 complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus		GO:0006364,rRNA processing	
TOM40_HUMAN	O96008	TOMM40	Mitochondrial import receptor subunit TOM40 homolog	0.891877848	0.794585623	1.068279567	0.26792132	0.8432317355	0.6681004435	0.8432317355	0.6681004435	1.26213317728474	0.357903	0	0.792309415517723	0.357553	0	GO:0005829,cytosol;GO:0016021,integral component of membrane;GO:0031307,integral component of mitochondrial outer membrane;GO:0044233,mitochondria-associated endoplasmic reticulum membrane;GO:0005743,mitochondrial inner membrane;GO:0005741,mitochondrial outer membrane;GO:0005742,mitochondrial outer membrane translocase complex;GO:0005739,mitochondrion;GO:0046930,pore complex	GO:0015288,porin activity;GO:0008320,protein transmembrane transporter activity	GO:0016236,macroautophagy;GO:0030150,protein import into mitochondrial matrix;GO:0006626,protein targeting to mitochondrion	hsa:10452,path:hsa05014,Amyotrophic lateral sclerosis (ALS)
OSBL8_HUMAN	Q9BZF1	OSBPL8	Oxysterol-binding protein-related protein 8	0.46248469	0.351458152	0.704027484	0.985395506	0.406971421	0.844711495	0.406971421	0.844711495	0.481787478220596	0.208496	0	2.07560396482976	0.208828	0	GO:0032541,cortical endoplasmic reticulum;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0031965,nuclear membrane	GO:0015485,cholesterol binding;GO:0070273,phosphatidylinositol-4-phosphate binding;GO:0001786,phosphatidylserine binding;GO:0140343,phosphatidylserine transfer activity;GO:0032934,sterol binding;GO:0015248,sterol transporter activity;GO:0008289,lipid binding	GO:0032148,activation of protein kinase B activity;GO:0045444,fat cell differentiation;GO:0030336,negative regulation of cell migration;GO:0010891,negative regulation of sequestering of triglyceride;GO:0036150,phosphatidylserine acyl-chain remodeling;GO:0015914,phospholipid transport;GO:0046326,positive regulation of glucose import;GO:0046628,positive regulation of insulin receptor signaling pathway;GO:0051897,positive regulation of protein kinase B signaling;GO:0090204,protein localization to nuclear pore;GO:0006869,lipid transport	
PTPRS_HUMAN	Q13332	PTPRS	Receptor-type tyrosine-protein phosphatase S	2.55E-05	2.55E-05	2.55E-05	0.076541766	2.55e-005	0.038283633	2.55e-005	0.038283633	0.000666080985574175	0.000000	-1	1501.31894117647	0.000000	1	GO:0030424,axon;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0030426,growth cone;GO:0005887,integral component of plasma membrane;GO:0099061,integral component of postsynaptic density membrane;GO:0099056,integral component of presynaptic membrane;GO:0030285,integral component of synaptic vesicle membrane;GO:0043204,perikaryon;GO:0005886,plasma membrane;GO:0098685,Schaffer collateral - CA1 synapse;GO:0016021,integral component of membrane	GO:0035374,chondroitin sulfate binding;GO:0043395,heparan sulfate proteoglycan binding;GO:0008201,heparin binding;GO:0004721,phosphoprotein phosphatase activity;GO:0004725,protein tyrosine phosphatase activity	GO:0021549,cerebellum development;GO:0021987,cerebral cortex development;GO:0022038,corpus callosum development;GO:0090557,establishment of endothelial intestinal barrier;GO:0021766,hippocampus development;GO:0050804,modulation of chemical synaptic transmission;GO:0030517,negative regulation of axon extension;GO:0048681,negative regulation of axon regeneration;GO:0048671,negative regulation of collateral sprouting;GO:0061000,negative regulation of dendritic spine development;GO:0032687,negative regulation of interferon-alpha production;GO:0032688,negative regulation of interferon-beta production;GO:0010977,negative regulation of neuron projection development;GO:0034164,negative regulation of toll-like receptor 9 signaling pathway;GO:0035335,peptidyl-tyrosine dephosphorylation;GO:0006470,protein dephosphorylation;GO:0099151,regulation of postsynaptic density assembly;GO:0021510,spinal cord development;GO:0099560,synaptic membrane adhesion	
STAT6_HUMAN	P42226	STAT6	Signal transducer and activator of transcription 6	0.340348658	0.559366903	0.740990929	0.802617716	0.4498577805	0.7718043225	0.4498577805	0.7718043225	0.582865070051483	0.301323	0	1.71566294050126	0.301610	0	GO:0000785,chromatin;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005737,cytoplasm;GO:0005634,nucleus;GO:0045121,membrane raft	GO:0001228,DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700,DNA-binding transcription factor activity;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0042802,identical protein binding;GO:0019903,protein phosphatase binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000977,RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0003677,DNA binding	GO:0019221,cytokine-mediated signaling pathway;GO:0006952,defense response;GO:0060397,growth hormone receptor signaling pathway via JAK-STAT;GO:0035771,interleukin-4-mediated signaling pathway;GO:0120162,positive regulation of cold-induced thermogenesis;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0032481,positive regulation of type I interferon production;GO:0007259,receptor signaling pathway via JAK-STAT;GO:0042127,regulation of cell population proliferation;GO:0006357,regulation of transcription by RNA polymerase II;GO:0043434,response to peptide hormone;GO:0007165,signal transduction;GO:0070301,cellular response to hydrogen peroxide;GO:1902170,cellular response to reactive nitrogen species;GO:0033598,mammary gland epithelial cell proliferation;GO:0060443,mammary gland morphogenesis;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0002829,negative regulation of type 2 immune response;GO:0048295,positive regulation of isotype switching to IgE isotypes;GO:0002296,T-helper 1 cell lineage commitment	hsa:6778,path:hsa04630,Jak-STAT signaling pathway;hsa:6778,path:hsa04217,Necroptosis;hsa:6778,path:hsa04658,Th1 and Th2 cell differentiation;hsa:6778,path:hsa04659,Th17 cell differentiation;hsa:6778,path:hsa05200,Pathways in cancer;hsa:6778,path:hsa05321,Inflammatory bowel disease (IBD);hsa:6778,path:hsa05161,Hepatitis B
TM14C_HUMAN	Q9P0S9	TMEM14C	Transmembrane protein 14C	0.886182293	2.423704334	0.870886577	0.748723381	1.6549433135	0.809804979	1.6549433135	0.809804979	2.04363193165796	0.220571	0	0.489324904601936	0.220024	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0031966,mitochondrial membrane		GO:0030218,erythrocyte differentiation;GO:0006783,heme biosynthetic process;GO:0006839,mitochondrial transport;GO:0070453,regulation of heme biosynthetic process	
TOP1_HUMAN	P11387	TOP1	DNA topoisomerase 1	4.041765069	5.158719788	5.076265764	23.20078973	4.6002424285	14.138527747	4.6002424285	14.138527747	0.325369268343807	0.079042	0	3.07343101298471	0.079315	0	GO:0005694,chromosome;GO:0001650,fibrillar center;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body;GO:0043204,perikaryon;GO:0032993,protein-DNA complex	GO:0005524,ATP binding;GO:0003682,chromatin binding;GO:0003677,DNA binding;GO:0003917,DNA topoisomerase type I (single strand cut, ATP-independent) activity;GO:0003690,double-stranded DNA binding;GO:0019904,protein domain specific binding;GO:0004674,protein serine/threonine kinase activity;GO:0003723,RNA binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003697,single-stranded DNA binding;GO:0097100,supercoiled DNA binding	GO:0006338,chromatin remodeling;GO:0007059,chromosome segregation;GO:0032922,circadian regulation of gene expression;GO:0007623,circadian rhythm;GO:0006260,DNA replication;GO:0006265,DNA topological change;GO:0040016,embryonic cleavage;GO:0018105,peptidyl-serine phosphorylation;GO:0016310,phosphorylation;GO:0012501,programmed cell death;GO:0042493,response to drug;GO:0016032,viral process	
IPO5_HUMAN	O00410	IPO5	Importin-5	3.25193656	2.281223136	4.349284653	2.118949636	2.766579848	3.2341171445	2.766579848	3.2341171445	0.855435880764213	0.485545	0	1.16899468737112	0.485463	0	GO:0005737,cytoplasm;GO:0016020,membrane;GO:0005643,nuclear pore;GO:0005730,nucleolus;GO:0005634,nucleus	GO:0005095,GTPase inhibitor activity;GO:0061608,nuclear import signal receptor activity;GO:0008139,nuclear localization sequence binding;GO:0003723,RNA binding;GO:0031267,small GTPase binding	GO:0071230,cellular response to amino acid stimulus;GO:0045736,negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0006607,NLS-bearing protein import into nucleus;GO:0042307,positive regulation of protein import into nucleus;GO:0006606,protein import into nucleus;GO:0006610,ribosomal protein import into nucleus;GO:0016032,viral process	
NHLC2_HUMAN	Q8NBF2	NHLRC2	NHL repeat-containing protein 2	0.29493069	0.190511717	0.3840799	0.586260997	0.2427212035	0.4851704485	0.2427212035	0.4851704485	0.5002802710891	0.225397	0	1.99887954370661	0.225726	0	GO:0005829,cytosol;GO:0005576,extracellular region;GO:0031093,platelet alpha granule lumen		GO:0002576,platelet degranulation	
ECHM_HUMAN	P30084	ECHS1	Enoyl-CoA hydratase, mitochondrial	2.80584189	3.270435705	3.243023374	3.830717976	3.0381387975	3.536870675	3.0381387975	3.536870675	0.858990637959925	0.484152	0	1.16415704177518	0.484066	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0043956,3-hydroxypropionyl-CoA dehydratase activity;GO:0120092,crotonyl-CoA hydratase activity;GO:0004300,enoyl-CoA hydratase activity	GO:0009083,branched-chain amino acid catabolic process;GO:0006635,fatty acid beta-oxidation	hsa:1892,path:hsa00640,Propanoate metabolism;hsa:1892,path:hsa00650,Butanoate metabolism;hsa:1892,path:hsa00062,Fatty acid elongation;hsa:1892,path:hsa00071,Fatty acid degradation;hsa:1892,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:1892,path:hsa00310,Lysine degradation;hsa:1892,path:hsa00380,Tryptophan metabolism;hsa:1892,path:hsa00410,beta-Alanine metabolism
CSRP2_HUMAN	Q16527	CSRP2	Cysteine and glycine-rich protein 2	2.142366371	2.780155887	0.14366437	2.55E-05	2.461261129	0.071844935	2.461261129	0.071844935	34.2579630561291	0.000826	1	0.0291902936074037	0.000806	-1	GO:0005737,cytoplasm;GO:0005925,focal adhesion;GO:0005634,nucleus;GO:0030018,Z disc	GO:0042805,actinin binding;GO:0046872,metal ion binding;GO:0008307,structural constituent of muscle	GO:0030036,actin cytoskeleton organization;GO:0030154,cell differentiation;GO:0007275,multicellular organism development;GO:0060537,muscle tissue development;GO:0045214,sarcomere organization	
GMFB_HUMAN	P60983	GMFB	Glia maturation factor beta	1.10514432	7.203094992	0.274105845	0.062314894	4.154119656	0.1682103695	4.154119656	0.1682103695	24.6959784248022	0.002048	1	0.0404924228066097	0.002006	-1		GO:0003779,actin binding;GO:0071933,Arp2/3 complex binding;GO:0008047,enzyme activator activity;GO:0008083,growth factor activity;GO:0004860,protein kinase inhibitor activity	GO:0071846,actin filament debranching;GO:0034316,negative regulation of Arp2/3 complex-mediated actin nucleation;GO:0007399,nervous system development;GO:0006468,protein phosphorylation	
CYC_HUMAN	P99999	CYCS	Cytochrome c	7.295333416	13.25009391	6.956784219	5.203420686	10.272713663	6.0801024525	10.272713663	6.0801024525	1.68956259261324	0.270962	0	0.591869164464221	0.270470	0	GO:0005829,cytosol;GO:0005743,mitochondrial inner membrane;GO:0005758,mitochondrial intermembrane space;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0070469,respirasome	GO:0009055,electron transfer activity;GO:0020037,heme binding;GO:0046872,metal ion binding	GO:0008635,activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;GO:0006915,apoptotic process;GO:0045333,cellular respiration;GO:0034599,cellular response to oxidative stress;GO:0006123,mitochondrial electron transport, cytochrome c to oxygen;GO:0006122,mitochondrial electron transport, ubiquinol to cytochrome c;GO:0007005,mitochondrion organization;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	hsa:54205,path:hsa04210,Apoptosis;hsa:54205,path:hsa04215,Apoptosis - multiple species;hsa:54205,path:hsa04115,p53 signaling pathway;hsa:54205,path:hsa05200,Pathways in cancer;hsa:54205,path:hsa05210,Colorectal cancer;hsa:54205,path:hsa05222,Small cell lung cancer;hsa:54205,path:hsa05010,Alzheimer disease;hsa:54205,path:hsa05012,Parkinson disease;hsa:54205,path:hsa05014,Amyotrophic lateral sclerosis (ALS);hsa:54205,path:hsa05016,Huntington disease;hsa:54205,path:hsa05416,Viral myocarditis;hsa:54205,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:54205,path:hsa05130,Pathogenic Escherichia coli infection;hsa:54205,path:hsa05132,Salmonella infection;hsa:54205,path:hsa05131,Shigellosis;hsa:54205,path:hsa05134,Legionellosis;hsa:54205,path:hsa05152,Tuberculosis;hsa:54205,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:54205,path:hsa05162,Measles;hsa:54205,path:hsa05164,Influenza A;hsa:54205,path:hsa05161,Hepatitis B;hsa:54205,path:hsa05160,Hepatitis C;hsa:54205,path:hsa05168,Herpes simplex virus 1 infection;hsa:54205,path:hsa05163,Human cytomegalovirus infection;hsa:54205,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:54205,path:hsa05169,Epstein-Barr virus infection;hsa:54205,path:hsa05145,Toxoplasmosis;hsa:54205,path:hsa01524,Platinum drug resistance
6PGL_HUMAN	O95336	PGLS	6-phosphogluconolactonase	3.885906767	3.881473563	3.378404092	3.216241885	3.883690165	3.2973229885	3.883690165	3.2973229885	1.17783128269359	0.379877	0	0.849018033986241	0.379569	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0017057,6-phosphogluconolactonase activity	GO:0005975,carbohydrate metabolic process;GO:0006098,pentose-phosphate shunt;GO:0009051,pentose-phosphate shunt, oxidative branch	hsa:25796,path:hsa00030,Pentose phosphate pathway
DNJB1_HUMAN	P25685	DNAJB1	DnaJ homolog subfamily B member 1	0.905197857	2.253246736	0.895911336	0.873817136	1.5792222965	0.884864236	1.5792222965	0.884864236	1.7847057573926	0.255886	0	0.560316453206814	0.255375	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0043025,neuronal cell body;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0014069,postsynaptic density;GO:0061827,sperm head	GO:0001671,ATPase activator activity;GO:0051117,ATPase binding;GO:0045296,cadherin binding;GO:0051087,chaperone binding;GO:0030544,Hsp70 protein binding;GO:0044183,protein folding chaperone;GO:0003714,transcription corepressor activity;GO:0051082,unfolded protein binding	GO:0051085,chaperone cofactor-dependent protein refolding;GO:0030900,forebrain development;GO:0090084,negative regulation of inclusion body assembly;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0097201,negative regulation of transcription from RNA polymerase II promoter in response to stress;GO:0032781,positive regulation of ATPase activity;GO:1900034,regulation of cellular response to heat;GO:0006986,response to unfolded protein;GO:0006457,protein folding	hsa:3337,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:3337,path:hsa05164,Influenza A
TIA1_HUMAN	P31483	TIA1	Nucleolysin TIA-1 isoform p40	0.023331435	0.020121082	0.060953011	0.054031327	0.0217262585	0.057492169	0.0217262585	0.057492169	0.377899440530762	0.118441	0	2.64620661675364	0.118755	0	GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0097165,nuclear stress granule;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex	GO:0035925,mRNA 3'-UTR AU-rich region binding;GO:0008143,poly(A) binding;GO:0003723,RNA binding	GO:0006915,apoptotic process;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0001818,negative regulation of cytokine production;GO:0017148,negative regulation of translation;GO:1904037,positive regulation of epithelial cell apoptotic process;GO:1903608,protein localization to cytoplasmic stress granule;GO:0048024,regulation of mRNA splicing, via spliceosome	
FIS1_HUMAN	Q9Y3D6	FIS1	Mitochondrial fission 1 protein	1.065913705	2.199291438	0.289234651	0.208127718	1.6326025715	0.2486811845	1.6326025715	0.2486811845	6.56504260578669	0.039723	1	0.152321936055458	0.039378	-1	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0031307,integral component of mitochondrial outer membrane;GO:0005779,integral component of peroxisomal membrane;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005778,peroxisomal membrane;GO:0005777,peroxisome;GO:0032991,protein-containing complex	GO:0042802,identical protein binding	GO:0000422,autophagy of mitochondrion;GO:0035584,calcium-mediated signaling using intracellular calcium source;GO:0000266,mitochondrial fission;GO:0043653,mitochondrial fragmentation involved in apoptotic process;GO:0008053,mitochondrial fusion;GO:0070584,mitochondrion morphogenesis;GO:1903579,negative regulation of ATP metabolic process;GO:0032471,negative regulation of endoplasmic reticulum calcium ion concentration;GO:2000192,negative regulation of fatty acid transport;GO:0016559,peroxisome fission;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007204,positive regulation of cytosolic calcium ion concentration;GO:2001244,positive regulation of intrinsic apoptotic signaling pathway;GO:0051561,positive regulation of mitochondrial calcium ion concentration;GO:0090141,positive regulation of mitochondrial fission;GO:0090314,positive regulation of protein targeting to membrane;GO:0045046,protein import into peroxisome membrane;GO:0006626,protein targeting to mitochondrion;GO:0010821,regulation of mitochondrion organization;GO:0001836,release of cytochrome c from mitochondria	hsa:51024,path:hsa04137,Mitophagy - animal
PSA4_HUMAN	P25789	PSMA4	Proteasome subunit alpha type-4	4.671871003	6.534876397	5.058160163	3.137427794	5.6033737	4.0977939785	5.6033737	4.0977939785	1.36741225386131	0.333017	0	0.731308350628123	0.332621	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body;GO:0000502,proteasome complex;GO:0005839,proteasome core complex;GO:0019773,proteasome core complex, alpha-subunit complex	GO:0004175,endopeptidase activity;GO:0004298,threonine-type endopeptidase activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0051603,proteolysis involved in cellular protein catabolic process;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:5685,path:hsa03050,Proteasome
ADH1G_HUMAN	P00326	ADH1C	Alcohol dehydrogenase 1C	2.55E-05	2.55E-05	1.474916952	2.55E-05	2.55e-005	0.737471226	2.55e-005	0.737471226	3.4577620252807e-005	0.000000	-1	28920.4402352941	0.000000	1	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0004022,alcohol dehydrogenase (NAD+) activity;GO:0004024,alcohol dehydrogenase activity, zinc-dependent;GO:0004745,retinol dehydrogenase activity;GO:0008270,zinc ion binding;GO:0016491,oxidoreductase activity	GO:0006069,ethanol oxidation;GO:0042573,retinoic acid metabolic process;GO:0042572,retinol metabolic process	hsa:126,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:126,path:hsa00071,Fatty acid degradation;hsa:126,path:hsa00350,Tyrosine metabolism;hsa:126,path:hsa00830,Retinol metabolism;hsa:126,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:126,path:hsa00982,Drug metabolism - cytochrome P450;hsa:126,path:hsa05204,Chemical carcinogenesis
NUCB1_HUMAN	Q02818	NUCB1	Nucleobindin-1	2.117549223	2.432296377	2.19640391	3.566307787	2.2749228	2.8813558485	2.2749228	2.8813558485	0.789532053524141	0.477348	0	1.26657302326919	0.477465	0	GO:0005801,cis-Golgi network;GO:0005769,early endosome;GO:0005788,endoplasmic reticulum lumen;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0090498,extrinsic component of Golgi membrane;GO:0032580,Golgi cisterna membrane;GO:0005798,Golgi-associated vesicle;GO:0098547,lumenal side of Golgi membrane;GO:0016020,membrane;GO:0005634,nucleus;GO:0005791,rough endoplasmic reticulum;GO:0005802,trans-Golgi network;GO:0005576,extracellular region;GO:0005794,Golgi apparatus;GO:0005737,cytoplasm	GO:0005509,calcium ion binding;GO:0003677,DNA binding;GO:0001965,G-protein alpha-subunit binding;GO:0005085,guanyl-nucleotide exchange factor activity;GO:0046872,metal ion binding	GO:0044267,cellular protein metabolic process;GO:0043687,post-translational protein modification;GO:1903533,regulation of protein targeting;GO:0072718,response to cisplatin;GO:0007264,small GTPase mediated signal transduction	
KPYR_HUMAN	P30613	PKLR	Pyruvate kinase PKLR	0.009240725	0.001123526	0.00071773	0.07481329	0.0051821255	0.03776551	0.0051821255	0.03776551	0.137218469974323	0.003157	-1	7.28764866848555	0.003190	1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0005524,ATP binding;GO:0016301,kinase activity;GO:0000287,magnesium ion binding;GO:0030955,potassium ion binding;GO:0004743,pyruvate kinase activity	GO:0006754,ATP biosynthetic process;GO:0061621,canonical glycolysis;GO:0071872,cellular response to epinephrine stimulus;GO:0032869,cellular response to insulin stimulus;GO:0006096,glycolytic process;GO:0042866,pyruvate biosynthetic process;GO:0033198,response to ATP;GO:0051591,response to cAMP;GO:0009749,response to glucose;GO:0009408,response to heat;GO:0001666,response to hypoxia;GO:0010226,response to lithium ion;GO:0007584,response to nutrient	hsa:5313,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:5313,path:hsa00620,Pyruvate metabolism;hsa:5313,path:hsa00230,Purine metabolism;hsa:5313,path:hsa04910,Insulin signaling pathway;hsa:5313,path:hsa04930,Type II diabetes mellitus;hsa:5313,path:hsa04950,Maturity onset diabetes of the young;hsa:5313,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
RBBP5_HUMAN	Q15291	RBBP5	Retinoblastoma-binding protein 5	0.273383351	0.026838256	0.243746755	5.466378123	0.1501108035	2.855062439	0.1501108035	2.855062439	0.0525770650229902	0.000014	-1	19.0196999311912	0.000014	1	GO:0035097,histone methyltransferase complex;GO:0071339,MLL1 complex;GO:0044666,MLL3/4 complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048188,Set1C/COMPASS complex	GO:0035064,methylated histone binding;GO:0000976,transcription regulatory region sequence-specific DNA binding	GO:1904837,beta-catenin-TCF complex assembly;GO:0006974,cellular response to DNA damage stimulus;GO:0051568,histone H3-K4 methylation;GO:0043687,post-translational protein modification;GO:0045652,regulation of megakaryocyte differentiation;GO:0043627,response to estrogen	hsa:5929,path:hsa04934,Cushing syndrome
KVD15_HUMAN	A0A087WSY6	IGKV3D-15	Immunoglobulin kappa variable 3D-15	3.961321269	2.552806483	2.848493939	14.58025304	3.257063876	8.7143734895	3.257063876	8.7143734895	0.373757663694866	0.115136	0	2.67553042287955	0.115448	0	GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0005576,extracellular region		GO:0002250,adaptive immune response;GO:0006955,immune response;GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response	
YMEL1_HUMAN	Q96TA2	YME1L1	ATP-dependent zinc metalloprotease YME1L1	0.053700504	0.013222877	0.049294857	0.09694548	0.0334616905	0.0731201685	0.0334616905	0.0731201685	0.457626003692812	0.186658	0	2.18519050912864	0.186993	0	GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0016604,nuclear body	GO:0005524,ATP binding;GO:0004176,ATP-dependent peptidase activity;GO:0046872,metal ion binding;GO:0004222,metalloendopeptidase activity;GO:0016887,ATPase activity	GO:0008283,cell population proliferation;GO:0006851,mitochondrial calcium ion transmembrane transport;GO:0035694,mitochondrial protein catabolic process;GO:0034982,mitochondrial protein processing;GO:0007005,mitochondrion organization;GO:0043066,negative regulation of apoptotic process;GO:0034214,protein hexamerization;GO:0006515,protein quality control for misfolded or incompletely synthesized proteins;GO:0006508,proteolysis	
TS101_HUMAN	Q99816	TSG101	Tumor susceptibility gene 101 protein	0.655006901	0.219116528	0.408552039	0.544420952	0.4370617145	0.4764864955	0.4370617145	0.4764864955	0.917259394815314	0.462136	0	1.09020415124922	0.462001	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0000813,ESCRT I complex;GO:0070062,extracellular exosome;GO:0090543,Flemming body;GO:0043657,host cell;GO:0005770,late endosome;GO:0031902,late endosome membrane;GO:0005815,microtubule organizing center;GO:0005771,multivesicular body;GO:0005730,nucleolus;GO:0005886,plasma membrane	GO:0048306,calcium-dependent protein binding;GO:0003677,DNA binding;GO:0030374,nuclear receptor coactivator activity;GO:0042803,protein homodimerization activity;GO:0044877,protein-containing complex binding;GO:0003714,transcription corepressor activity;GO:0043130,ubiquitin binding;GO:0031625,ubiquitin protein ligase binding;GO:0046790,virion binding	GO:0097352,autophagosome maturation;GO:0007050,cell cycle arrest;GO:0051301,cell division;GO:0016197,endosomal transport;GO:0008333,endosome to lysosome transport;GO:1990182,exosomal secretion;GO:0006858,extracellular transport;GO:0075733,intracellular transport of virus;GO:0030216,keratinocyte differentiation;GO:0016236,macroautophagy;GO:0036258,multivesicular body assembly;GO:0008285,negative regulation of cell population proliferation;GO:0042059,negative regulation of epidermal growth factor receptor signaling pathway;GO:0007175,negative regulation of epidermal growth factor-activated receptor activity;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:1903543,positive regulation of exosomal secretion;GO:2000397,positive regulation of ubiquitin-dependent endocytosis;GO:1903774,positive regulation of viral budding via host ESCRT complex;GO:1902188,positive regulation of viral release from host cell;GO:0006513,protein monoubiquitination;GO:0015031,protein transport;GO:0001558,regulation of cell growth;GO:1903551,regulation of extracellular exosome assembly;GO:0043405,regulation of MAP kinase activity;GO:0043162,ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0046755,viral budding;GO:0039702,viral budding via host ESCRT complex;GO:0019058,viral life cycle;GO:0006464,cellular protein modification process	hsa:7251,path:hsa04144,Endocytosis
DQB1_HUMAN	P01920	HLA-DQB1	HLA class II histocompatibility antigen, DQ beta 1 chain	1.330554314	4.540206407	1.757551689	2.623589194	2.9353803605	2.1905704415	2.9353803605	2.1905704415	1.34000728983177	0.339242	0	0.746264596907934	0.338857	0	GO:0009986,cell surface;GO:0031901,early endosome membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0000139,Golgi membrane;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0042612,MHC class I protein complex;GO:0032398,MHC class Ib protein complex;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0030667,secretory granule membrane;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0030666,endocytic vesicle membrane;GO:0001772,immunological synapse;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0042613,MHC class II protein complex;GO:0032588,trans-Golgi network membrane;GO:0030658,transport vesicle membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0010008,endosome membrane;GO:0005882,intermediate filament;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0005797,Golgi medial cisterna;GO:0042824,MHC class I peptide loading complex;GO:0035577,azurophil granule membrane;GO:0033106,cis-Golgi network membrane;GO:0005769,early endosome;GO:0031527,filopodium membrane;GO:0005771,multivesicular body	GO:0030881,beta-2-microglobulin binding;GO:0042288,MHC class I protein binding;GO:0046703,natural killer cell lectin-like receptor binding;GO:0042605,peptide antigen binding;GO:0005102,signaling receptor binding;GO:0042608,T cell receptor binding;GO:0051087,chaperone binding;GO:0046977,TAP binding;GO:0023026,MHC class II protein complex binding;GO:0032395,MHC class II receptor activity;GO:0030247,polysaccharide binding;GO:0042609,CD4 receptor binding;GO:0005200,structural constituent of cytoskeleton;GO:0042610,CD8 receptor binding;GO:0003723,RNA binding;GO:0062061,TAP complex binding;GO:0071889,14-3-3 protein binding;GO:0046978,TAP1 binding;GO:0046979,TAP2 binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:1990405,protein antigen binding;GO:0015643,toxic substance binding;GO:0008134,transcription factor binding;GO:0031625,ubiquitin protein ligase binding;GO:0046872,metal ion binding	GO:0002250,adaptive immune response;GO:0019731,antibacterial humoral response;GO:0002476,antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0002477,antigen processing and presentation of exogenous peptide antigen via MHC class Ib;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0036037,CD8-positive, alpha-beta T cell activation;GO:0050830,defense response to Gram-positive bacterium;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0002519,natural killer cell tolerance induction;GO:0045953,negative regulation of natural killer cell mediated cytotoxicity;GO:0001815,positive regulation of antibody-dependent cellular cytotoxicity;GO:2001187,positive regulation of CD8-positive, alpha-beta T cell activation;GO:2000566,positive regulation of CD8-positive, alpha-beta T cell proliferation;GO:0002639,positive regulation of immunoglobulin production;GO:0032736,positive regulation of interleukin-13 production;GO:0032753,positive regulation of interleukin-4 production;GO:0002729,positive regulation of natural killer cell cytokine production;GO:0045954,positive regulation of natural killer cell mediated cytotoxicity;GO:0002717,positive regulation of natural killer cell mediated immunity;GO:0032819,positive regulation of natural killer cell proliferation;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:0032759,positive regulation of TRAIL production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0042270,protection from natural killer cell mediated cytotoxicity;GO:0050776,regulation of immune response;GO:0002715,regulation of natural killer cell mediated immunity;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process;GO:0002486,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006952,defense response;GO:0016045,detection of bacterium;GO:0006955,immune response;GO:0043312,neutrophil degranulation;GO:2001198,regulation of dendritic cell differentiation;GO:0032655,regulation of interleukin-12 production;GO:0032675,regulation of interleukin-6 production;GO:0002667,regulation of T cell anergy;GO:0002491,antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002504,antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0050890,cognition;GO:0002469,myeloid dendritic cell antigen processing and presentation;GO:0002503,peptide antigen assembly with MHC class II protein complex;GO:2000516,positive regulation of CD4-positive, alpha-beta T cell activation;GO:0032831,positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0043382,positive regulation of memory T cell differentiation;GO:0045622,regulation of T-helper cell differentiation;GO:0050852,T cell receptor signaling pathway;GO:0002399,MHC class II protein complex assembly;GO:2001190,positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0042102,positive regulation of T cell proliferation;GO:0032729,positive regulation of interferon-gamma production;GO:0050870,positive regulation of T cell activation;GO:0008544,epidermis development;GO:0006959,humoral immune response;GO:0002437,inflammatory response to antigenic stimulus;GO:0030225,macrophage differentiation;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0032689,negative regulation of interferon-gamma production;GO:0042130,negative regulation of T cell proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0033674,positive regulation of kinase activity;GO:0043410,positive regulation of MAPK cascade;GO:0045657,positive regulation of monocyte differentiation;GO:0001934,positive regulation of protein phosphorylation;GO:0002842,positive regulation of T cell mediated immune response to tumor cell;GO:0045893,positive regulation of transcription, DNA-templated;GO:0046598,positive regulation of viral entry into host cell;GO:0051262,protein tetramerization;GO:0032653,regulation of interleukin-10 production;GO:0032673,regulation of interleukin-4 production;GO:0007165,signal transduction;GO:0042088,T-helper 1 type immune response;GO:0002587,negative regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0045580,regulation of T cell differentiation;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002485,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent;GO:0042590,antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:2000568,positive regulation of memory T cell activation;GO:0002726,positive regulation of T cell cytokine production;GO:0016567,protein ubiquitination;GO:0001913,T cell mediated cytotoxicity;GO:0002419,T cell mediated cytotoxicity directed against tumor cell target;GO:0002728,negative regulation of natural killer cell cytokine production;GO:0043322,negative regulation of natural killer cell degranulation;GO:1901215,negative regulation of neuron death;GO:0002725,negative regulation of T cell cytokine production;GO:0043323,positive regulation of natural killer cell degranulation;GO:0071346,cellular response to interferon-gamma;GO:0006968,cellular defense response;GO:0002767,immune response-inhibiting cell surface receptor signaling pathway;GO:0016525,negative regulation of angiogenesis;GO:2001199,negative regulation of dendritic cell differentiation;GO:0070317,negative regulation of G0 to G1 transition;GO:0050777,negative regulation of immune response;GO:0051898,negative regulation of protein kinase B signaling;GO:0001915,negative regulation of T cell mediated cytotoxicity;GO:0002451,peripheral B cell tolerance induction;GO:2000774,positive regulation of cellular senescence;GO:2000353,positive regulation of endothelial cell apoptotic process;GO:0032735,positive regulation of interleukin-12 production;GO:0060907,positive regulation of macrophage cytokine production;GO:0045591,positive regulation of regulatory T cell differentiation;GO:0002666,positive regulation of T cell tolerance induction;GO:0002645,positive regulation of tolerance induction;GO:0070207,protein homotrimerization;GO:0019882,antigen processing and presentation;GO:0002344,B cell affinity maturation;GO:0046635,positive regulation of alpha-beta T cell activation;GO:0002579,positive regulation of antigen processing and presentation;GO:0002827,positive regulation of T-helper 1 type immune response	hsa:3133,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3133,path:hsa04144,Endocytosis;hsa:3133,path:hsa04145,Phagosome;hsa:3133,path:hsa04218,Cellular senescence;hsa:3133,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3133,path:hsa04612,Antigen processing and presentation;hsa:3133,path:hsa05203,Viral carcinogenesis;hsa:3133,path:hsa05320,Autoimmune thyroid disease;hsa:3133,path:hsa05330,Allograft rejection;hsa:3133,path:hsa05332,Graft-versus-host disease;hsa:3133,path:hsa05416,Viral myocarditis;hsa:3133,path:hsa04940,Type I diabetes mellitus;hsa:3133,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3133,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3133,path:hsa05168,Herpes simplex virus 1 infection;hsa:3133,path:hsa05163,Human cytomegalovirus infection;hsa:3133,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3133,path:hsa05169,Epstein-Barr virus infection;hsa:3133,path:hsa05165,Human papillomavirus infection;hsa:3106,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3106,path:hsa04144,Endocytosis;hsa:3106,path:hsa04145,Phagosome;hsa:3106,path:hsa04218,Cellular senescence;hsa:3106,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3106,path:hsa04612,Antigen processing and presentation;hsa:3106,path:hsa05203,Viral carcinogenesis;hsa:3106,path:hsa05320,Autoimmune thyroid disease;hsa:3106,path:hsa05330,Allograft rejection;hsa:3106,path:hsa05332,Graft-versus-host disease;hsa:3106,path:hsa05416,Viral myocarditis;hsa:3106,path:hsa04940,Type I diabetes mellitus;hsa:3106,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3106,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3106,path:hsa05168,Herpes simplex virus 1 infection;hsa:3106,path:hsa05163,Human cytomegalovirus infection;hsa:3106,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3106,path:hsa05169,Epstein-Barr virus infection;hsa:3106,path:hsa05165,Human papillomavirus infection;hsa:3122,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3122,path:hsa04145,Phagosome;hsa:3122,path:hsa04640,Hematopoietic cell lineage;hsa:3122,path:hsa04612,Antigen processing and presentation;hsa:3122,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3122,path:hsa04659,Th17 cell differentiation;hsa:3122,path:hsa04672,Intestinal immune network for IgA production;hsa:3122,path:hsa05310,Asthma;hsa:3122,path:hsa05322,Systemic lupus erythematosus;hsa:3122,path:hsa05323,Rheumatoid arthritis;hsa:3122,path:hsa05320,Autoimmune thyroid disease;hsa:3122,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3122,path:hsa05330,Allograft rejection;hsa:3122,path:hsa05332,Graft-versus-host disease;hsa:3122,path:hsa05416,Viral myocarditis;hsa:3122,path:hsa04940,Type I diabetes mellitus;hsa:3122,path:hsa05150,Staphylococcus aureus infection;hsa:3122,path:hsa05152,Tuberculosis;hsa:3122,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3122,path:hsa05164,Influenza A;hsa:3122,path:hsa05168,Herpes simplex virus 1 infection;hsa:3122,path:hsa05169,Epstein-Barr virus infection;hsa:3122,path:hsa05145,Toxoplasmosis;hsa:3122,path:hsa05140,Leishmaniasis;hsa:3109,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3109,path:hsa04145,Phagosome;hsa:3109,path:hsa04640,Hematopoietic cell lineage;hsa:3109,path:hsa04612,Antigen processing and presentation;hsa:3109,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3109,path:hsa04659,Th17 cell differentiation;hsa:3109,path:hsa04672,Intestinal immune network for IgA production;hsa:3109,path:hsa05310,Asthma;hsa:3109,path:hsa05322,Systemic lupus erythematosus;hsa:3109,path:hsa05323,Rheumatoid arthritis;hsa:3109,path:hsa05320,Autoimmune thyroid disease;hsa:3109,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3109,path:hsa05330,Allograft rejection;hsa:3109,path:hsa05332,Graft-versus-host disease;hsa:3109,path:hsa05416,Viral myocarditis;hsa:3109,path:hsa04940,Type I diabetes mellitus;hsa:3109,path:hsa05150,Staphylococcus aureus infection;hsa:3109,path:hsa05152,Tuberculosis;hsa:3109,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3109,path:hsa05164,Influenza A;hsa:3109,path:hsa05168,Herpes simplex virus 1 infection;hsa:3109,path:hsa05169,Epstein-Barr virus infection;hsa:3109,path:hsa05145,Toxoplasmosis;hsa:3109,path:hsa05140,Leishmaniasis;hsa:3115,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3115,path:hsa04145,Phagosome;hsa:3115,path:hsa04640,Hematopoietic cell lineage;hsa:3115,path:hsa04612,Antigen processing and presentation;hsa:3115,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3115,path:hsa04659,Th17 cell differentiation;hsa:3115,path:hsa04672,Intestinal immune network for IgA production;hsa:3115,path:hsa05310,Asthma;hsa:3115,path:hsa05322,Systemic lupus erythematosus;hsa:3115,path:hsa05323,Rheumatoid arthritis;hsa:3115,path:hsa05320,Autoimmune thyroid disease;hsa:3115,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3115,path:hsa05330,Allograft rejection;hsa:3115,path:hsa05332,Graft-versus-host disease;hsa:3115,path:hsa05416,Viral myocarditis;hsa:3115,path:hsa04940,Type I diabetes mellitus;hsa:3115,path:hsa05150,Staphylococcus aureus infection;hsa:3115,path:hsa05152,Tuberculosis;hsa:3115,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3115,path:hsa05164,Influenza A;hsa:3115,path:hsa05168,Herpes simplex virus 1 infection;hsa:3115,path:hsa05169,Epstein-Barr virus infection;hsa:3115,path:hsa05145,Toxoplasmosis;hsa:3115,path:hsa05140,Leishmaniasis;hsa:3123,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3123,path:hsa04145,Phagosome;hsa:3123,path:hsa04640,Hematopoietic cell lineage;hsa:3123,path:hsa04612,Antigen processing and presentation;hsa:3123,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3123,path:hsa04659,Th17 cell differentiation;hsa:3123,path:hsa04672,Intestinal immune network for IgA production;hsa:3123,path:hsa05310,Asthma;hsa:3123,path:hsa05322,Systemic lupus erythematosus;hsa:3123,path:hsa05323,Rheumatoid arthritis;hsa:3123,path:hsa05320,Autoimmune thyroid disease;hsa:3123,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3123,path:hsa05330,Allograft rejection;hsa:3123,path:hsa05332,Graft-versus-host disease;hsa:3123,path:hsa05416,Viral myocarditis;hsa:3123,path:hsa04940,Type I diabetes mellitus;hsa:3123,path:hsa05150,Staphylococcus aureus infection;hsa:3123,path:hsa05152,Tuberculosis;hsa:3123,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3123,path:hsa05164,Influenza A;hsa:3123,path:hsa05168,Herpes simplex virus 1 infection;hsa:3123,path:hsa05169,Epstein-Barr virus infection;hsa:3123,path:hsa05145,Toxoplasmosis;hsa:3123,path:hsa05140,Leishmaniasis;hsa:3111,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3111,path:hsa04145,Phagosome;hsa:3111,path:hsa04640,Hematopoietic cell lineage;hsa:3111,path:hsa04612,Antigen processing and presentation;hsa:3111,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3111,path:hsa04659,Th17 cell differentiation;hsa:3111,path:hsa04672,Intestinal immune network for IgA production;hsa:3111,path:hsa05310,Asthma;hsa:3111,path:hsa05322,Systemic lupus erythematosus;hsa:3111,path:hsa05323,Rheumatoid arthritis;hsa:3111,path:hsa05320,Autoimmune thyroid disease;hsa:3111,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3111,path:hsa05330,Allograft rejection;hsa:3111,path:hsa05332,Graft-versus-host disease;hsa:3111,path:hsa05416,Viral myocarditis;hsa:3111,path:hsa04940,Type I diabetes mellitus;hsa:3111,path:hsa05150,Staphylococcus aureus infection;hsa:3111,path:hsa05152,Tuberculosis;hsa:3111,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3111,path:hsa05164,Influenza A;hsa:3111,path:hsa05168,Herpes simplex virus 1 infection;hsa:3111,path:hsa05169,Epstein-Barr virus infection;hsa:3111,path:hsa05145,Toxoplasmosis;hsa:3111,path:hsa05140,Leishmaniasis;hsa:3112,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3112,path:hsa04145,Phagosome;hsa:3112,path:hsa04640,Hematopoietic cell lineage;hsa:3112,path:hsa04612,Antigen processing and presentation;hsa:3112,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3112,path:hsa04659,Th17 cell differentiation;hsa:3112,path:hsa04672,Intestinal immune network for IgA production;hsa:3112,path:hsa05310,Asthma;hsa:3112,path:hsa05322,Systemic lupus erythematosus;hsa:3112,path:hsa05323,Rheumatoid arthritis;hsa:3112,path:hsa05320,Autoimmune thyroid disease;hsa:3112,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3112,path:hsa05330,Allograft rejection;hsa:3112,path:hsa05332,Graft-versus-host disease;hsa:3112,path:hsa05416,Viral myocarditis;hsa:3112,path:hsa04940,Type I diabetes mellitus;hsa:3112,path:hsa05150,Staphylococcus aureus infection;hsa:3112,path:hsa05152,Tuberculosis;hsa:3112,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3112,path:hsa05164,Influenza A;hsa:3112,path:hsa05168,Herpes simplex virus 1 infection;hsa:3112,path:hsa05169,Epstein-Barr virus infection;hsa:3112,path:hsa05145,Toxoplasmosis;hsa:3112,path:hsa05140,Leishmaniasis;hsa:3105,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3105,path:hsa04144,Endocytosis;hsa:3105,path:hsa04145,Phagosome;hsa:3105,path:hsa04218,Cellular senescence;hsa:3105,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3105,path:hsa04612,Antigen processing and presentation;hsa:3105,path:hsa05203,Viral carcinogenesis;hsa:3105,path:hsa05320,Autoimmune thyroid disease;hsa:3105,path:hsa05330,Allograft rejection;hsa:3105,path:hsa05332,Graft-versus-host disease;hsa:3105,path:hsa05416,Viral myocarditis;hsa:3105,path:hsa04940,Type I diabetes mellitus;hsa:3105,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3105,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3105,path:hsa05168,Herpes simplex virus 1 infection;hsa:3105,path:hsa05163,Human cytomegalovirus infection;hsa:3105,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3105,path:hsa05169,Epstein-Barr virus infection;hsa:3105,path:hsa05165,Human papillomavirus infection;hsa:3134,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3134,path:hsa04144,Endocytosis;hsa:3134,path:hsa04145,Phagosome;hsa:3134,path:hsa04218,Cellular senescence;hsa:3134,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3134,path:hsa04612,Antigen processing and presentation;hsa:3134,path:hsa05203,Viral carcinogenesis;hsa:3134,path:hsa05320,Autoimmune thyroid disease;hsa:3134,path:hsa05330,Allograft rejection;hsa:3134,path:hsa05332,Graft-versus-host disease;hsa:3134,path:hsa05416,Viral myocarditis;hsa:3134,path:hsa04940,Type I diabetes mellitus;hsa:3134,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3134,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3134,path:hsa05168,Herpes simplex virus 1 infection;hsa:3134,path:hsa05163,Human cytomegalovirus infection;hsa:3134,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3134,path:hsa05169,Epstein-Barr virus infection;hsa:3134,path:hsa05165,Human papillomavirus infection;hsa:3119,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3119,path:hsa04145,Phagosome;hsa:3119,path:hsa04640,Hematopoietic cell lineage;hsa:3119,path:hsa04612,Antigen processing and presentation;hsa:3119,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3119,path:hsa04659,Th17 cell differentiation;hsa:3119,path:hsa04672,Intestinal immune network for IgA production;hsa:3119,path:hsa05310,Asthma;hsa:3119,path:hsa05322,Systemic lupus erythematosus;hsa:3119,path:hsa05323,Rheumatoid arthritis;hsa:3119,path:hsa05320,Autoimmune thyroid disease;hsa:3119,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3119,path:hsa05330,Allograft rejection;hsa:3119,path:hsa05332,Graft-versus-host disease;hsa:3119,path:hsa05416,Viral myocarditis;hsa:3119,path:hsa04940,Type I diabetes mellitus;hsa:3119,path:hsa05150,Staphylococcus aureus infection;hsa:3119,path:hsa05152,Tuberculosis;hsa:3119,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3119,path:hsa05164,Influenza A;hsa:3119,path:hsa05168,Herpes simplex virus 1 infection;hsa:3119,path:hsa05169,Epstein-Barr virus infection;hsa:3119,path:hsa05145,Toxoplasmosis;hsa:3119,path:hsa05140,Leishmaniasis;hsa:3113,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3113,path:hsa04145,Phagosome;hsa:3113,path:hsa04640,Hematopoietic cell lineage;hsa:3113,path:hsa04612,Antigen processing and presentation;hsa:3113,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3113,path:hsa04659,Th17 cell differentiation;hsa:3113,path:hsa04672,Intestinal immune network for IgA production;hsa:3113,path:hsa05310,Asthma;hsa:3113,path:hsa05322,Systemic lupus erythematosus;hsa:3113,path:hsa05323,Rheumatoid arthritis;hsa:3113,path:hsa05320,Autoimmune thyroid disease;hsa:3113,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3113,path:hsa05330,Allograft rejection;hsa:3113,path:hsa05332,Graft-versus-host disease;hsa:3113,path:hsa05416,Viral myocarditis;hsa:3113,path:hsa04940,Type I diabetes mellitus;hsa:3113,path:hsa05150,Staphylococcus aureus infection;hsa:3113,path:hsa05152,Tuberculosis;hsa:3113,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3113,path:hsa05164,Influenza A;hsa:3113,path:hsa05168,Herpes simplex virus 1 infection;hsa:3113,path:hsa05169,Epstein-Barr virus infection;hsa:3113,path:hsa05145,Toxoplasmosis;hsa:3113,path:hsa05140,Leishmaniasis;hsa:3125,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3125,path:hsa04145,Phagosome;hsa:3125,path:hsa04640,Hematopoietic cell lineage;hsa:3125,path:hsa04612,Antigen processing and presentation;hsa:3125,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3125,path:hsa04659,Th17 cell differentiation;hsa:3125,path:hsa04672,Intestinal immune network for IgA production;hsa:3125,path:hsa05310,Asthma;hsa:3125,path:hsa05322,Systemic lupus erythematosus;hsa:3125,path:hsa05323,Rheumatoid arthritis;hsa:3125,path:hsa05320,Autoimmune thyroid disease;hsa:3125,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3125,path:hsa05330,Allograft rejection;hsa:3125,path:hsa05332,Graft-versus-host disease;hsa:3125,path:hsa05416,Viral myocarditis;hsa:3125,path:hsa04940,Type I diabetes mellitus;hsa:3125,path:hsa05150,Staphylococcus aureus infection;hsa:3125,path:hsa05152,Tuberculosis;hsa:3125,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3125,path:hsa05164,Influenza A;hsa:3125,path:hsa05168,Herpes simplex virus 1 infection;hsa:3125,path:hsa05169,Epstein-Barr virus infection;hsa:3125,path:hsa05145,Toxoplasmosis;hsa:3125,path:hsa05140,Leishmaniasis;hsa:3126,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3126,path:hsa04145,Phagosome;hsa:3126,path:hsa04640,Hematopoietic cell lineage;hsa:3126,path:hsa04612,Antigen processing and presentation;hsa:3126,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3126,path:hsa04659,Th17 cell differentiation;hsa:3126,path:hsa04672,Intestinal immune network for IgA production;hsa:3126,path:hsa05310,Asthma;hsa:3126,path:hsa05322,Systemic lupus erythematosus;hsa:3126,path:hsa05323,Rheumatoid arthritis;hsa:3126,path:hsa05320,Autoimmune thyroid disease;hsa:3126,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3126,path:hsa05330,Allograft rejection;hsa:3126,path:hsa05332,Graft-versus-host disease;hsa:3126,path:hsa05416,Viral myocarditis;hsa:3126,path:hsa04940,Type I diabetes mellitus;hsa:3126,path:hsa05150,Staphylococcus aureus infection;hsa:3126,path:hsa05152,Tuberculosis;hsa:3126,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3126,path:hsa05164,Influenza A;hsa:3126,path:hsa05168,Herpes simplex virus 1 infection;hsa:3126,path:hsa05169,Epstein-Barr virus infection;hsa:3126,path:hsa05145,Toxoplasmosis;hsa:3126,path:hsa05140,Leishmaniasis;hsa:3107,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3107,path:hsa04144,Endocytosis;hsa:3107,path:hsa04145,Phagosome;hsa:3107,path:hsa04218,Cellular senescence;hsa:3107,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3107,path:hsa04612,Antigen processing and presentation;hsa:3107,path:hsa05203,Viral carcinogenesis;hsa:3107,path:hsa05320,Autoimmune thyroid disease;hsa:3107,path:hsa05330,Allograft rejection;hsa:3107,path:hsa05332,Graft-versus-host disease;hsa:3107,path:hsa05416,Viral myocarditis;hsa:3107,path:hsa04940,Type I diabetes mellitus;hsa:3107,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3107,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3107,path:hsa05168,Herpes simplex virus 1 infection;hsa:3107,path:hsa05163,Human cytomegalovirus infection;hsa:3107,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3107,path:hsa05169,Epstein-Barr virus infection;hsa:3107,path:hsa05165,Human papillomavirus infection;hsa:3135,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3135,path:hsa04144,Endocytosis;hsa:3135,path:hsa04145,Phagosome;hsa:3135,path:hsa04218,Cellular senescence;hsa:3135,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3135,path:hsa04612,Antigen processing and presentation;hsa:3135,path:hsa05203,Viral carcinogenesis;hsa:3135,path:hsa05320,Autoimmune thyroid disease;hsa:3135,path:hsa05330,Allograft rejection;hsa:3135,path:hsa05332,Graft-versus-host disease;hsa:3135,path:hsa05416,Viral myocarditis;hsa:3135,path:hsa04940,Type I diabetes mellitus;hsa:3135,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3135,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3135,path:hsa05168,Herpes simplex virus 1 infection;hsa:3135,path:hsa05163,Human cytomegalovirus infection;hsa:3135,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3135,path:hsa05169,Epstein-Barr virus infection;hsa:3135,path:hsa05165,Human papillomavirus infection;hsa:3127,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3127,path:hsa04145,Phagosome;hsa:3127,path:hsa04640,Hematopoietic cell lineage;hsa:3127,path:hsa04612,Antigen processing and presentation;hsa:3127,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3127,path:hsa04659,Th17 cell differentiation;hsa:3127,path:hsa04672,Intestinal immune network for IgA production;hsa:3127,path:hsa05310,Asthma;hsa:3127,path:hsa05322,Systemic lupus erythematosus;hsa:3127,path:hsa05323,Rheumatoid arthritis;hsa:3127,path:hsa05320,Autoimmune thyroid disease;hsa:3127,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3127,path:hsa05330,Allograft rejection;hsa:3127,path:hsa05332,Graft-versus-host disease;hsa:3127,path:hsa05416,Viral myocarditis;hsa:3127,path:hsa04940,Type I diabetes mellitus;hsa:3127,path:hsa05150,Staphylococcus aureus infection;hsa:3127,path:hsa05152,Tuberculosis;hsa:3127,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3127,path:hsa05164,Influenza A;hsa:3127,path:hsa05168,Herpes simplex virus 1 infection;hsa:3127,path:hsa05169,Epstein-Barr virus infection;hsa:3127,path:hsa05145,Toxoplasmosis;hsa:3127,path:hsa05140,Leishmaniasis;hsa:3118,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3118,path:hsa04145,Phagosome;hsa:3118,path:hsa04640,Hematopoietic cell lineage;hsa:3118,path:hsa04612,Antigen processing and presentation;hsa:3118,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3118,path:hsa04659,Th17 cell differentiation;hsa:3118,path:hsa04672,Intestinal immune network for IgA production;hsa:3118,path:hsa05310,Asthma;hsa:3118,path:hsa05322,Systemic lupus erythematosus;hsa:3118,path:hsa05323,Rheumatoid arthritis;hsa:3118,path:hsa05320,Autoimmune thyroid disease;hsa:3118,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3118,path:hsa05330,Allograft rejection;hsa:3118,path:hsa05332,Graft-versus-host disease;hsa:3118,path:hsa05416,Viral myocarditis;hsa:3118,path:hsa04940,Type I diabetes mellitus;hsa:3118,path:hsa05150,Staphylococcus aureus infection;hsa:3118,path:hsa05152,Tuberculosis;hsa:3118,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3118,path:hsa05164,Influenza A;hsa:3118,path:hsa05168,Herpes simplex virus 1 infection;hsa:3118,path:hsa05169,Epstein-Barr virus infection;hsa:3118,path:hsa05145,Toxoplasmosis;hsa:3118,path:hsa05140,Leishmaniasis;hsa:3117,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3117,path:hsa04145,Phagosome;hsa:3117,path:hsa04640,Hematopoietic cell lineage;hsa:3117,path:hsa04612,Antigen processing and presentation;hsa:3117,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3117,path:hsa04659,Th17 cell differentiation;hsa:3117,path:hsa04672,Intestinal immune network for IgA production;hsa:3117,path:hsa05310,Asthma;hsa:3117,path:hsa05322,Systemic lupus erythematosus;hsa:3117,path:hsa05323,Rheumatoid arthritis;hsa:3117,path:hsa05320,Autoimmune thyroid disease;hsa:3117,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3117,path:hsa05330,Allograft rejection;hsa:3117,path:hsa05332,Graft-versus-host disease;hsa:3117,path:hsa05416,Viral myocarditis;hsa:3117,path:hsa04940,Type I diabetes mellitus;hsa:3117,path:hsa05150,Staphylococcus aureus infection;hsa:3117,path:hsa05152,Tuberculosis;hsa:3117,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3117,path:hsa05164,Influenza A;hsa:3117,path:hsa05168,Herpes simplex virus 1 infection;hsa:3117,path:hsa05169,Epstein-Barr virus infection;hsa:3117,path:hsa05145,Toxoplasmosis;hsa:3117,path:hsa05140,Leishmaniasis
AL1L2_HUMAN	Q3SY69	ALDH1L2	Mitochondrial 10-formyltetrahydrofolate dehydrogenase	0.542275261	0.404728768	0.33118241	0.274971786	0.4735020145	0.303077098	0.4735020145	0.303077098	1.56231538979564	0.293252	0	0.640075625274874	0.292791	0	GO:0070062,extracellular exosome;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005737,cytoplasm	GO:0004029,aldehyde dehydrogenase (NAD+) activity;GO:0016155,formyltetrahydrofolate dehydrogenase activity;GO:0016742,hydroxymethyl-, formyl- and related transferase activity;GO:0016620,oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	GO:0009258,10-formyltetrahydrofolate catabolic process;GO:0009058,biosynthetic process;GO:0046655,folic acid metabolic process;GO:0006730,one-carbon metabolic process	hsa:160428,path:hsa00670,One carbon pool by folate
HV118_HUMAN	A0A0C4DH31	IGHV1-18	Immunoglobulin heavy variable 1-18	0.569475375	0.019097193	0.326700211	0.416004473	0.294286284	0.371352342	0.294286284	0.371352342	0.792471867593607	0.479611	0	1.26187444740034	0.479725	0	GO:0009897,external side of plasma membrane;GO:0042571,immunoglobulin complex, circulating;GO:0005576,extracellular region;GO:0005886,plasma membrane;GO:0019814,immunoglobulin complex	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006956,complement activation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
TBA4A_HUMAN	P68366	TUBA4A	Tubulin alpha-4A chain	3.945732576	13.56073818	7.611792781	4.548730115	8.753235378	6.080261448	8.753235378	6.080261448	1.43961496604381	0.317405	0	0.694630177920482	0.316982	0	GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005874,microtubule;GO:0015630,microtubule cytoskeleton	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0019901,protein kinase binding;GO:0005200,structural constituent of cytoskeleton	GO:0097711,ciliary basal body-plasma membrane docking;GO:0000086,G2/M transition of mitotic cell cycle;GO:0000226,microtubule cytoskeleton organization;GO:0000278,mitotic cell cycle;GO:0002576,platelet degranulation;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0007017,microtubule-based process	hsa:7277,path:hsa04145,Phagosome;hsa:7277,path:hsa04210,Apoptosis;hsa:7277,path:hsa04530,Tight junction;hsa:7277,path:hsa04540,Gap junction;hsa:7277,path:hsa05130,Pathogenic Escherichia coli infection
UFSP2_HUMAN	Q9NUQ7	UFSP2	Ufm1-specific protease 2	0.199805507	0.157612783	0.391912981	0.290725971	0.178709145	0.341319476	0.178709145	0.341319476	0.523583204493142	0.246825	0	1.90991611537283	0.247145	0	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005634,nucleus	GO:0016790,thiolester hydrolase activity;GO:0071567,UFM1 hydrolase activity	GO:0006508,proteolysis;GO:0033146,regulation of intracellular estrogen receptor signaling pathway	
MIC60_HUMAN	Q16891	IMMT	MICOS complex subunit MIC60	5.817090687	5.458185552	7.52757547	8.449724716	5.6376381195	7.988650093	5.6376381195	7.988650093	0.705705977088663	0.409691	0	1.41702073167274	0.409882	0	GO:0016020,membrane;GO:0140275,MIB complex;GO:0061617,MICOS complex;GO:0005743,mitochondrial inner membrane;GO:0005758,mitochondrial intermembrane space;GO:0005739,mitochondrion;GO:0001401,SAM complex;GO:0016021,integral component of membrane	GO:0003723,RNA binding	GO:0042407,cristae formation;GO:0007007,inner mitochondrial membrane organization;GO:0051560,mitochondrial calcium ion homeostasis	
AL1B1_HUMAN	P30837	ALDH1B1	Aldehyde dehydrogenase X, mitochondrial	1.221017595	0.482631099	0.756716553	2.55E-05	0.851824347	0.3783710265	0.851824347	0.3783710265	2.25129380248675	0.197152	0	0.444189025393049	0.196590	0	GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0004029,aldehyde dehydrogenase (NAD+) activity;GO:0043878,glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity;GO:0051287,NAD binding;GO:0016491,oxidoreductase activity	GO:0005975,carbohydrate metabolic process;GO:0006068,ethanol catabolic process;GO:0006069,ethanol oxidation	hsa:219,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:219,path:hsa00053,Ascorbate and aldarate metabolism;hsa:219,path:hsa00620,Pyruvate metabolism;hsa:219,path:hsa00071,Fatty acid degradation;hsa:219,path:hsa00561,Glycerolipid metabolism;hsa:219,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:219,path:hsa00310,Lysine degradation;hsa:219,path:hsa00330,Arginine and proline metabolism;hsa:219,path:hsa00340,Histidine metabolism;hsa:219,path:hsa00380,Tryptophan metabolism;hsa:219,path:hsa00410,beta-Alanine metabolism
PUR1_HUMAN	Q06203	PPAT	Amidophosphoribosyltransferase	0.523923477	0.209279584	0.676272739	0.574563815	0.3666015305	0.625418277	0.3666015305	0.625418277	0.586170158407443	0.304340	0	1.70598926891278	0.304625	0	GO:0005829,cytosol	GO:0051539,4 iron, 4 sulfur cluster binding;GO:0004044,amidophosphoribosyltransferase activity;GO:0042802,identical protein binding;GO:0046872,metal ion binding	GO:0006189,'de novo' IMP biosynthetic process;GO:0031100,animal organ regeneration;GO:0035690,cellular response to drug;GO:0032869,cellular response to insulin stimulus;GO:0000082,G1/S transition of mitotic cell cycle;GO:0006543,glutamine catabolic process;GO:0001822,kidney development;GO:0007595,lactation;GO:0060135,maternal process involved in female pregnancy;GO:0009116,nucleoside metabolic process;GO:0009113,purine nucleobase biosynthetic process;GO:0006164,purine nucleotide biosynthetic process;GO:0009168,purine ribonucleoside monophosphate biosynthetic process	hsa:5471,path:hsa00230,Purine metabolism;hsa:5471,path:hsa00250,Alanine, aspartate and glutamate metabolism
SRSF5_HUMAN	Q13243	SRSF5	Serine/arginine-rich splicing factor 5	0.636580053	0.019609207	0.399958531	0.085413543	0.32809463	0.242686037	0.32809463	0.242686037	1.35193039556701	0.336512	0	0.73968305119776	0.336123	0	GO:0005829,cytosol;GO:0016607,nuclear speck;GO:0005730,nucleolus;GO:0005654,nucleoplasm	GO:0003729,mRNA binding;GO:0043422,protein kinase B binding;GO:0003723,RNA binding	GO:0032869,cellular response to insulin stimulus;GO:0097421,liver regeneration;GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0006397,mRNA processing;GO:0006376,mRNA splice site selection;GO:0000398,mRNA splicing, via spliceosome;GO:0033120,positive regulation of RNA splicing;GO:0051726,regulation of cell cycle;GO:0006405,RNA export from nucleus	hsa:6430,path:hsa03040,Spliceosome;hsa:6430,path:hsa05168,Herpes simplex virus 1 infection
TADBP_HUMAN	Q13148	TARDBP	TAR DNA-binding protein 43	1.260991643	0.383990759	1.710402637	1.430960947	0.822491201	1.570681792	0.822491201	1.570681792	0.523652343325821	0.246888	0	1.90966394545052	0.247208	0	GO:0010494,cytoplasmic stress granule;GO:0035061,interchromatin granule;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005726,perichromatin fibrils	GO:0003690,double-stranded DNA binding;GO:0042802,identical protein binding;GO:0003730,mRNA 3'-UTR binding;GO:0097157,pre-mRNA intronic binding;GO:0003723,RNA binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0061158,3'-UTR-mediated mRNA destabilization;GO:0070935,3'-UTR-mediated mRNA stabilization;GO:0006397,mRNA processing;GO:0043922,negative regulation by host of viral transcription;GO:0010629,negative regulation of gene expression;GO:0001933,negative regulation of protein phosphorylation;GO:0071765,nuclear inner membrane organization;GO:0032024,positive regulation of insulin secretion;GO:0042307,positive regulation of protein import into nucleus;GO:0042981,regulation of apoptotic process;GO:0051726,regulation of cell cycle;GO:0042752,regulation of circadian rhythm;GO:0010468,regulation of gene expression;GO:0031647,regulation of protein stability;GO:0034976,response to endoplasmic reticulum stress;GO:0048511,rhythmic process;GO:0008380,RNA splicing	
DPOD1_HUMAN	P28340	POLD1	DNA polymerase delta catalytic subunit	1.389248399	2.003449324	1.12704133	1.064891097	1.6963488615	1.0959662135	1.6963488615	1.0959662135	1.54781127429345	0.295963	0	0.646073598641078	0.295506	0	GO:0016235,aggresome;GO:0005829,cytosol;GO:0043625,delta DNA polymerase complex;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0000109,nucleotide-excision repair complex;GO:0005634,nucleus	GO:0008296,3'-5'-exodeoxyribonuclease activity;GO:0051539,4 iron, 4 sulfur cluster binding;GO:0003682,chromatin binding;GO:0003684,damaged DNA binding;GO:0003677,DNA binding;GO:0003887,DNA-directed DNA polymerase activity;GO:0046872,metal ion binding;GO:0000166,nucleotide binding;GO:0008408,3'-5' exonuclease activity;GO:0019899,enzyme binding	GO:0006287,base-excision repair, gap-filling;GO:0034644,cellular response to UV;GO:0071897,DNA biosynthetic process;GO:0042769,DNA damage response, detection of DNA damage;GO:0006281,DNA repair;GO:0006260,DNA replication;GO:0045004,DNA replication proofreading;GO:0000731,DNA synthesis involved in DNA repair;GO:0006261,DNA-dependent DNA replication;GO:0070987,error-free translesion synthesis;GO:0055089,fatty acid homeostasis;GO:0006298,mismatch repair;GO:0006297,nucleotide-excision repair, DNA gap filling;GO:0033683,nucleotide-excision repair, DNA incision;GO:0006296,nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0009411,response to UV;GO:0000723,telomere maintenance;GO:0032201,telomere maintenance via semi-conservative replication;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0019985,translesion synthesis	hsa:5424,path:hsa03030,DNA replication;hsa:5424,path:hsa03410,Base excision repair;hsa:5424,path:hsa03420,Nucleotide excision repair;hsa:5424,path:hsa03430,Mismatch repair;hsa:5424,path:hsa03440,Homologous recombination
RM37_HUMAN	Q9BZE1	MRPL37	39S ribosomal protein L37, mitochondrial	0.372490061	0.493839248	0.557073445	1.71404193	0.4331646545	1.1355576875	0.4331646545	1.1355576875	0.38145543750722	0.121302	0	2.62153819731845	0.121618	0	GO:0005743,mitochondrial inner membrane;GO:0005762,mitochondrial large ribosomal subunit;GO:0005761,mitochondrial ribosome;GO:0005739,mitochondrion;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination;GO:0006412,translation	
AP1B1_HUMAN	Q10567	AP1B1	AP-1 complex subunit beta-1	6.910760433	10.71600359	12.2920462	11.31846535	8.8133820115	11.805255775	8.8133820115	11.805255775	0.746564257435583	0.443411	0	1.33946942951027	0.443565	0	GO:0030131,clathrin adaptor complex;GO:0030665,clathrin-coated vesicle membrane;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005765,lysosomal membrane;GO:0032588,trans-Golgi network membrane;GO:0030117,membrane coat	GO:0030276,clathrin binding;GO:0019901,protein kinase binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0007368,determination of left/right symmetry;GO:0007507,heart development;GO:0006886,intracellular protein transport;GO:0001822,kidney development;GO:0006892,post-Golgi vesicle-mediated transport;GO:0050690,regulation of defense response to virus by virus;GO:0016192,vesicle-mediated transport	hsa:162,path:hsa04142,Lysosome;hsa:162,path:hsa05170,Human immunodeficiency virus 1 infection
CATG_HUMAN	P08311	CTSG	Cathepsin G	1.417465175	3.541184895	1.575025792	6.802635252	2.479325035	4.188830522	2.479325035	4.188830522	0.59188955532539	0.309552	0	1.68950438642265	0.309834	0	GO:0035578,azurophil granule lumen;GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043231,intracellular membrane-bounded organelle;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0030141,secretory granule	GO:0008201,heparin binding;GO:0008233,peptidase activity;GO:0004252,serine-type endopeptidase activity;GO:0008236,serine-type peptidase activity	GO:0002003,angiotensin maturation;GO:0019731,antibacterial humoral response;GO:0019730,antimicrobial humoral response;GO:0044267,cellular protein metabolic process;GO:0071222,cellular response to lipopolysaccharide;GO:0019221,cytokine-mediated signaling pathway;GO:0050832,defense response to fungus;GO:0050829,defense response to Gram-negative bacterium;GO:0022617,extracellular matrix disassembly;GO:0006955,immune response;GO:0033668,negative regulation by symbiont of host apoptotic process;GO:0043312,neutrophil degranulation;GO:0070946,neutrophil-mediated killing of gram-positive bacterium;GO:0050778,positive regulation of immune response;GO:0006468,protein phosphorylation;GO:0006508,proteolysis;GO:0035590,purinergic nucleotide receptor signaling pathway	hsa:1511,path:hsa04080,Neuroactive ligand-receptor interaction;hsa:1511,path:hsa04142,Lysosome;hsa:1511,path:hsa04614,Renin-angiotensin system;hsa:1511,path:hsa05322,Systemic lupus erythematosus;hsa:1511,path:hsa05146,Amoebiasis
DNJC5_HUMAN	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	2.55E-05	0.049966866	0.043667138	0.143684848	0.024996183	0.093675993	0.024996183	0.093675993	0.266836594942741	0.043207	-1	3.74761190538571	0.043409	1	GO:0031225,anchored component of membrane;GO:0098993,anchored component of synaptic vesicle membrane;GO:0035577,azurophil granule membrane;GO:0042584,chromaffin granule membrane;GO:0061202,clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0005765,lysosomal membrane;GO:0042470,melanosome;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0031594,neuromuscular junction;GO:0005886,plasma membrane;GO:0035579,specific granule membrane	GO:0043008,ATP-dependent protein binding	GO:0061077,chaperone-mediated protein folding;GO:0006887,exocytosis;GO:0043524,negative regulation of neuron apoptotic process;GO:0007269,neurotransmitter secretion;GO:0043312,neutrophil degranulation;GO:0045055,regulated exocytosis;GO:0098693,regulation of synaptic vesicle cycle;GO:0016079,synaptic vesicle exocytosis	hsa:80331,path:hsa04141,Protein processing in endoplasmic reticulum
LSG1_HUMAN	Q9H089	LSG1	Large subunit GTPase 1 homolog	0.071401847	0.023779654	0.12922351	0.084009211	0.0475907505	0.1066163605	0.0475907505	0.1066163605	0.446373804890854	0.176619	0	2.24027483029502	0.176955	0	GO:0015030,Cajal body;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0016020,membrane;GO:0016604,nuclear body;GO:0005654,nucleoplasm	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0000166,nucleotide binding	GO:0051168,nuclear export;GO:0000054,ribosomal subunit export from nucleus	hsa:55341,path:hsa03008,Ribosome biogenesis in eukaryotes
NSDHL_HUMAN	Q15738	NSDHL	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	1.500161995	1.116336455	1.391763202	0.278265325	1.308249225	0.8350142635	1.308249225	0.8350142635	1.5667387758341	0.292433	0	0.638268494674629	0.291971	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0005811,lipid droplet	GO:0003854,3-beta-hydroxy-delta5-steroid dehydrogenase activity;GO:0102175,3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity;GO:0103066,4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol;GO:0103067,4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol;GO:0000252,C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity;GO:0016616,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0047012,sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity	GO:0006695,cholesterol biosynthetic process;GO:0008203,cholesterol metabolic process;GO:0001942,hair follicle development;GO:0060716,labyrinthine layer blood vessel development;GO:0007224,smoothened signaling pathway;GO:0006694,steroid biosynthetic process	hsa:50814,path:hsa00100,Steroid biosynthesis
RIDA_HUMAN	P52758	RIDA	2-iminobutanoate/2-iminopropanoate deaminase	0.048159765	0.148711865	0.108586849	2.55E-05	0.098435815	0.0543061745	0.098435815	0.0543061745	1.81260815931713	0.251698	0	0.551691216250914	0.251182	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005777,peroxisome	GO:0120242,2-iminobutanoate deaminase activity;GO:0120243,2-iminopropanoate deaminase activity;GO:0019239,deaminase activity;GO:0016892,endoribonuclease activity, producing 3'-phosphomonoesters;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0042802,identical protein binding;GO:0036041,long-chain fatty acid binding;GO:0046914,transition metal ion binding	GO:0019518,L-threonine catabolic process to glycine;GO:0006402,mRNA catabolic process;GO:0061157,mRNA destabilization;GO:0017148,negative regulation of translation;GO:1901565,organonitrogen compound catabolic process;GO:0007420,brain development;GO:0070314,G1 to G0 transition;GO:0001822,kidney development;GO:0030324,lung development;GO:0050680,negative regulation of epithelial cell proliferation;GO:0033993,response to lipid;GO:1902074,response to salt	
SYRM_HUMAN	Q5T160	RARS2	Probable arginine--tRNA ligase, mitochondrial	0.072055541	0.070586141	0.069307066	0.0414947	0.071320841	0.055400883	0.071320841	0.055400883	1.28735928270313	0.351694	0	0.776783927716164	0.351332	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005737,cytoplasm	GO:0004814,arginine-tRNA ligase activity;GO:0005524,ATP binding;GO:0003723,RNA binding	GO:0006420,arginyl-tRNA aminoacylation;GO:0032543,mitochondrial translation;GO:0006418,tRNA aminoacylation for protein translation	hsa:57038,path:hsa00970,Aminoacyl-tRNA biosynthesis
UBP24_HUMAN	Q9UPU5	USP24	Ubiquitin carboxyl-terminal hydrolase 24	0.391950373	0.264927837	0.386795763	0.195632802	0.328439105	0.2912142825	0.328439105	0.2912142825	1.12782622535006	0.393873	0	0.886661417799199	0.393593	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0004197,cysteine-type endopeptidase activity;GO:0004843,thiol-dependent deubiquitinase	GO:0016579,protein deubiquitination;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0016032,viral process	
P2RX4_HUMAN	Q99571	P2RX4	P2X purinoceptor 4	0.028621116	0.129402629	0.104613772	0.199985881	0.0790118725	0.1522998265	0.0790118725	0.1522998265	0.518791612018021	0.242412	0	1.92755622264236	0.242734	0	GO:0044297,cell body;GO:0030054,cell junction;GO:0043197,dendritic spine;GO:0070062,extracellular exosome;GO:0005639,integral component of nuclear inner membrane;GO:0005887,integral component of plasma membrane;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0043025,neuronal cell body;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0043195,terminal bouton;GO:0098794,postsynapse;GO:0016021,integral component of membrane	GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0005507,copper ion binding;GO:0004931,extracellularly ATP-gated cation channel activity;GO:0042802,identical protein binding;GO:0099604,ligand-gated calcium channel activity;GO:0001614,purinergic nucleotide receptor activity;GO:0005102,signaling receptor binding;GO:0008270,zinc ion binding;GO:0005216,ion channel activity	GO:0097190,apoptotic signaling pathway;GO:0048266,behavioral response to pain;GO:0007596,blood coagulation;GO:0070588,calcium ion transmembrane transport;GO:0019722,calcium-mediated signaling;GO:0071318,cellular response to ATP;GO:0071294,cellular response to zinc ion;GO:0042118,endothelial cell activation;GO:0034220,ion transmembrane transport;GO:0051899,membrane depolarization;GO:1904124,microglial cell migration;GO:0010614,negative regulation of cardiac muscle hypertrophy;GO:0019228,neuronal action potential;GO:0043536,positive regulation of blood vessel endothelial cell migration;GO:0051928,positive regulation of calcium ion transport;GO:0010524,positive regulation of calcium ion transport into cytosol;GO:0050850,positive regulation of calcium-mediated signaling;GO:2001028,positive regulation of endothelial cell chemotaxis;GO:1904141,positive regulation of microglial cell migration;GO:0045429,positive regulation of nitric oxide biosynthetic process;GO:0032308,positive regulation of prostaglandin secretion;GO:0051897,positive regulation of protein kinase B signaling;GO:0035590,purinergic nucleotide receptor signaling pathway;GO:0008217,regulation of blood pressure;GO:0055117,regulation of cardiac muscle contraction;GO:0050920,regulation of chemotaxis;GO:0002028,regulation of sodium ion transport;GO:0055119,relaxation of cardiac muscle;GO:0033198,response to ATP;GO:0048678,response to axon injury;GO:0034405,response to fluid shear stress;GO:0002931,response to ischemia;GO:0019233,sensory perception of pain;GO:0050975,sensory perception of touch;GO:0007165,signal transduction;GO:0001894,tissue homeostasis;GO:0006811,ion transport	hsa:5025,path:hsa04020,Calcium signaling pathway;hsa:5025,path:hsa04080,Neuroactive ligand-receptor interaction
DYN3_HUMAN	Q9UQ16	DNM3	Dynamin-3	0.102469011	0.149129984	0.216681525	0.096016397	0.1257994975	0.156348961	0.1257994975	0.156348961	0.804607185717083	0.488869	0	1.24284249227625	0.488972	0	GO:0061828,apical tubulobulbar complex;GO:0030424,axon;GO:0061829,basal tubulobulbar complex;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0043197,dendritic spine;GO:0044327,dendritic spine head;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0005794,Golgi apparatus;GO:0016020,membrane;GO:0005874,microtubule;GO:0015630,microtubule cytoskeleton;GO:0031966,mitochondrial membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0098844,postsynaptic endocytic zone membrane;GO:0098793,presynapse;GO:0043083,synaptic cleft	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0008017,microtubule binding;GO:0050998,nitric-oxide synthase binding;GO:0099186,structural constituent of postsynapse;GO:0031798,type 1 metabotropic glutamate receptor binding;GO:0031802,type 5 metabotropic glutamate receptor binding	GO:0003374,dynamin family protein polymerization involved in mitochondrial fission;GO:0006897,endocytosis;GO:0046847,filopodium assembly;GO:0061025,membrane fusion;GO:0000266,mitochondrial fission;GO:0061002,negative regulation of dendritic spine morphogenesis;GO:0051491,positive regulation of filopodium assembly;GO:1903423,positive regulation of synaptic vesicle recycling;GO:0098884,postsynaptic neurotransmitter receptor internalization;GO:0031623,receptor internalization;GO:0050803,regulation of synapse structure or activity;GO:0007416,synapse assembly;GO:0016185,synaptic vesicle budding from presynaptic endocytic zone membrane	hsa:26052,path:hsa04072,Phospholipase D signaling pathway;hsa:26052,path:hsa04144,Endocytosis;hsa:26052,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:26052,path:hsa04721,Synaptic vesicle cycle;hsa:26052,path:hsa05100,Bacterial invasion of epithelial cells
GGCT_HUMAN	O75223	GGCT	Gamma-glutamylcyclotransferase	23.12045108	15.53903261	6.142991458	1.629907516	19.329741845	3.886449487	19.329741845	3.886449487	4.97362487526395	0.064265	0	0.201060599679209	0.063824	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0003839,gamma-glutamylcyclotransferase activity;GO:0042803,protein homodimerization activity	GO:0006750,glutathione biosynthetic process;GO:0001836,release of cytochrome c from mitochondria	hsa:79017,path:hsa00480,Glutathione metabolism
PDXK_HUMAN	O00764	PDXK	Pyridoxal kinase	2.585393071	6.140342242	4.939719589	2.543092451	4.3628676565	3.74140602	4.3628676565	3.74140602	1.16610376772206	0.383092	0	0.857556615183108	0.382791	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0034774,secretory granule lumen;GO:0035580,specific granule lumen	GO:0005524,ATP binding;GO:0031403,lithium ion binding;GO:0000287,magnesium ion binding;GO:0030955,potassium ion binding;GO:0042803,protein homodimerization activity;GO:0008478,pyridoxal kinase activity;GO:0030170,pyridoxal phosphate binding;GO:0031402,sodium ion binding;GO:0008270,zinc ion binding	GO:0043312,neutrophil degranulation;GO:0009443,pyridoxal 5'-phosphate salvage;GO:0042816,vitamin B6 metabolic process	hsa:8566,path:hsa00750,Vitamin B6 metabolism
PTN12_HUMAN	Q05209	PTPN12	Tyrosine-protein phosphatase non-receptor type 12	0.089016662	0.297723945	0.240128202	0.162375318	0.1933703035	0.20125176	0.1933703035	0.20125176	0.960837825716406	0.446631	0	1.0407583602929	0.446463	0	GO:0042995,cell projection;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0002102,podosome	GO:0004726,non-membrane spanning protein tyrosine phosphatase activity;GO:0004721,phosphoprotein phosphatase activity;GO:0004725,protein tyrosine phosphatase activity;GO:0017124,SH3 domain binding	GO:0071345,cellular response to cytokine stimulus;GO:0071364,cellular response to epidermal growth factor stimulus;GO:0038128,ERBB2 signaling pathway;GO:1901185,negative regulation of ERBB signaling pathway;GO:2000587,negative regulation of platelet-derived growth factor receptor-beta signaling pathway;GO:0035335,peptidyl-tyrosine dephosphorylation;GO:0006470,protein dephosphorylation;GO:0042058,regulation of epidermal growth factor receptor signaling pathway;GO:0042246,tissue regeneration	
PTPRD_HUMAN	P23468	PTPRD	Receptor-type tyrosine-protein phosphatase delta	0.07418104	2.55E-05	0.026453296	0.110612622	0.03710327	0.068532959	0.03710327	0.068532959	0.541393083581872	0.263237	0	1.84708676620686	0.263549	0	GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0098686,hippocampal mossy fiber to CA3 synapse;GO:0005887,integral component of plasma membrane;GO:0099056,integral component of presynaptic membrane;GO:0005886,plasma membrane;GO:0098685,Schaffer collateral - CA1 synapse;GO:0016021,integral component of membrane	GO:0050839,cell adhesion molecule binding;GO:0004725,protein tyrosine phosphatase activity;GO:0005102,signaling receptor binding;GO:0005001,transmembrane receptor protein tyrosine phosphatase activity;GO:0008307,structural constituent of muscle	GO:0007157,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0050804,modulation of chemical synaptic transmission;GO:0046426,negative regulation of receptor signaling pathway via JAK-STAT;GO:0030182,neuron differentiation;GO:0006796,phosphate-containing compound metabolic process;GO:0050775,positive regulation of dendrite morphogenesis;GO:0051965,positive regulation of synapse assembly;GO:0097105,presynaptic membrane assembly;GO:0006470,protein dephosphorylation;GO:0050776,regulation of immune response;GO:0099151,regulation of postsynaptic density assembly;GO:1905606,regulation of presynapse assembly;GO:0099560,synaptic membrane adhesion;GO:0099545,trans-synaptic signaling by trans-synaptic complex;GO:0007185,transmembrane receptor protein tyrosine phosphatase signaling pathway	
CALR_HUMAN	P27797	CALR	Calreticulin	8.296024712	10.14865074	21.5568856	13.66861174	9.222337726	17.61274867	9.222337726	17.61274867	0.523617176330263	0.246856	0	1.90979220163944	0.247176	0	GO:0001669,acrosomal vesicle;GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0060473,cortical granule;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0071682,endocytic vesicle lumen;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0044322,endoplasmic reticulum quality control compartment;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0016020,membrane;GO:0042824,MHC class I peptide loading complex;GO:0005635,nuclear envelope;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0030670,phagocytic vesicle membrane;GO:0005844,polysome;GO:0033018,sarcoplasmic reticulum lumen;GO:0005790,smooth endoplasmic reticulum;GO:0030133,transport vesicle	GO:0050681,androgen receptor binding;GO:0005509,calcium ion binding;GO:0030246,carbohydrate binding;GO:0051087,chaperone binding;GO:0001849,complement component C1q complex binding;GO:0003677,DNA binding;GO:0042562,hormone binding;GO:0005178,integrin binding;GO:0005506,iron ion binding;GO:0003729,mRNA binding;GO:0042277,peptide binding;GO:0044183,protein folding chaperone;GO:0003723,RNA binding;GO:0031625,ubiquitin protein ligase binding;GO:0051082,unfolded protein binding;GO:0008270,zinc ion binding	GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0036500,ATF6-mediated unfolded protein response;GO:0055007,cardiac muscle cell differentiation;GO:0006874,cellular calcium ion homeostasis;GO:0071285,cellular response to lithium ion;GO:0090398,cellular senescence;GO:0030866,cortical actin cytoskeleton organization;GO:0030968,endoplasmic reticulum unfolded protein response;GO:0042921,glucocorticoid receptor signaling pathway;GO:0071157,negative regulation of cell cycle arrest;GO:0033144,negative regulation of intracellular steroid hormone receptor signaling pathway;GO:0045665,negative regulation of neuron differentiation;GO:0048387,negative regulation of retinoic acid receptor signaling pathway;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0017148,negative regulation of translation;GO:1901164,negative regulation of trophoblast cell migration;GO:0002502,peptide antigen assembly with MHC class I protein complex;GO:0045787,positive regulation of cell cycle;GO:0008284,positive regulation of cell population proliferation;GO:2000510,positive regulation of dendritic cell chemotaxis;GO:0010595,positive regulation of endothelial cell migration;GO:0010628,positive regulation of gene expression;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:0050766,positive regulation of phagocytosis;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0006611,protein export from nucleus;GO:0006457,protein folding;GO:0034975,protein folding in endoplasmic reticulum;GO:0034504,protein localization to nucleus;GO:0022417,protein maturation by protein folding;GO:0050821,protein stabilization;GO:0006898,receptor-mediated endocytosis;GO:0042981,regulation of apoptotic process;GO:0040020,regulation of meiotic nuclear division;GO:0006355,regulation of transcription, DNA-templated;GO:0042493,response to drug;GO:0032355,response to estradiol;GO:0033574,response to testosterone;GO:0051208,sequestering of calcium ion;GO:0007283,spermatogenesis;GO:1990668,vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane	hsa:811,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:811,path:hsa04145,Phagosome;hsa:811,path:hsa04612,Antigen processing and presentation;hsa:811,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:811,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:811,path:hsa05168,Herpes simplex virus 1 infection;hsa:811,path:hsa05163,Human cytomegalovirus infection;hsa:811,path:hsa05169,Epstein-Barr virus infection;hsa:811,path:hsa05142,Chagas disease (American trypanosomiasis)
SSH3_HUMAN	Q8TE77	SSH3	Protein phosphatase Slingshot homolog 3	0.163168863	0.396852154	0.492793035	10.64046194	0.2800105085	5.5666274875	0.2800105085	5.5666274875	0.0503016429837941	0.000010	-1	19.880066349367	0.000010	1	GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005634,nucleus	GO:0003779,actin binding;GO:0004721,phosphoprotein phosphatase activity;GO:0106306,protein serine phosphatase activity;GO:0106307,protein threonine phosphatase activity;GO:0004725,protein tyrosine phosphatase activity;GO:0008138,protein tyrosine/serine/threonine phosphatase activity;GO:0016791,phosphatase activity	GO:0030036,actin cytoskeleton organization;GO:0030837,negative regulation of actin filament polymerization	hsa:54961,path:hsa04810,Regulation of actin cytoskeleton;hsa:54961,path:hsa04360,Axon guidance
DCTN3_HUMAN	O75935	DCTN3	Dynactin subunit 3	0.940934558	5.813045366	0.128349546	0.127735008	3.376989962	0.128042277	3.376989962	0.128042277	26.3740230267851	0.001717	1	0.037916096417464	0.001680	-1	GO:0005813,centrosome;GO:0032154,cleavage furrow;GO:0000777,condensed chromosome kinetochore;GO:0005829,cytosol;GO:0005869,dynactin complex;GO:0005874,microtubule;GO:0030496,midbody;GO:0005730,nucleolus;GO:0048471,perinuclear region of cytoplasm;GO:0005819,spindle	GO:0005198,structural molecule activity	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0097711,ciliary basal body-plasma membrane docking;GO:0061640,cytoskeleton-dependent cytokinesis;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0000086,G2/M transition of mitotic cell cycle;GO:0007017,microtubule-based process;GO:0000278,mitotic cell cycle;GO:0010389,regulation of G2/M transition of mitotic cell cycle	
LCAP_HUMAN	Q9UIQ6	LNPEP	Leucyl-cystinyl aminopeptidase	1.445216991	1.686072051	1.727381303	1.85503273	1.565644521	1.7912070165	1.565644521	1.7912070165	0.874072347069773	0.478306	0	1.14407005707524	0.478207	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0031905,early endosome lumen;GO:0005576,extracellular region;GO:0005887,integral component of plasma membrane;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0004177,aminopeptidase activity;GO:0070006,metalloaminopeptidase activity;GO:0008237,metallopeptidase activity;GO:0042277,peptide binding;GO:0008270,zinc ion binding	GO:0002480,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0007267,cell-cell signaling;GO:0007565,female pregnancy;GO:0120163,negative regulation of cold-induced thermogenesis;GO:0043171,peptide catabolic process;GO:0000209,protein polyubiquitination;GO:0006508,proteolysis;GO:0008217,regulation of blood pressure;GO:0007165,signal transduction	hsa:4012,path:hsa04614,Renin-angiotensin system
NOP9_HUMAN	Q86U38	NOP9	Nucleolar protein 9	0.113227465	0.066548195	0.281800104	0.083839477	0.08988783	0.1828197905	0.08988783	0.1828197905	0.491674505009347	0.217516	0	2.03386588039782	0.217847	0	GO:0030686,90S preribosome;GO:0005730,nucleolus;GO:0030688,preribosome, small subunit precursor	GO:0003723,RNA binding	GO:0000480,endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000447,endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472,endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000056,ribosomal small subunit export from nucleus	
TBB2B_HUMAN	Q9BVA1	TUBB2B	Tubulin beta-2B chain	0.484659425	2.55E-05	0.107758686	2.55E-05	0.2423424625	0.053892093	0.2423424625	0.053892093	4.49680925363207	0.075646	0	0.222379901747512	0.075173	0	GO:0005737,cytoplasm;GO:0005874,microtubule;GO:0015630,microtubule cytoskeleton;GO:0005634,nucleus;GO:0098685,Schaffer collateral - CA1 synapse	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0046982,protein heterodimerization activity;GO:0005200,structural constituent of cytoskeleton	GO:1990403,embryonic brain development;GO:0000226,microtubule cytoskeleton organization;GO:0007017,microtubule-based process;GO:0000278,mitotic cell cycle;GO:0050804,modulation of chemical synaptic transmission;GO:0001764,neuron migration;GO:1902669,positive regulation of axon guidance	hsa:347733,path:hsa04145,Phagosome;hsa:347733,path:hsa04540,Gap junction;hsa:347733,path:hsa05130,Pathogenic Escherichia coli infection
AP2S1_HUMAN	P53680	AP2S1	AP-2 complex subunit sigma	1.971007496	9.568000777	1.425086636	3.034033606	5.7695041365	2.229560121	5.7695041365	2.229560121	2.58773202936204	0.166216	0	0.386438776756391	0.165645	0	GO:0030122,AP-2 adaptor complex;GO:0045334,clathrin-coated endocytic vesicle;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0005829,cytosol;GO:0030666,endocytic vesicle membrane;GO:0036020,endolysosome membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005886,plasma membrane	GO:0035615,clathrin adaptor activity	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0048268,clathrin coat assembly;GO:0072583,clathrin-dependent endocytosis;GO:0048013,ephrin receptor signaling pathway;GO:0006886,intracellular protein transport;GO:0034383,low-density lipoprotein particle clearance;GO:0032802,low-density lipoprotein particle receptor catabolic process;GO:0061024,membrane organization;GO:0050690,regulation of defense response to virus by virus;GO:0030100,regulation of endocytosis;GO:0016192,vesicle-mediated transport;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:1175,path:hsa04144,Endocytosis;hsa:1175,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:1175,path:hsa04721,Synaptic vesicle cycle;hsa:1175,path:hsa05016,Huntington disease
AFAD_HUMAN	P55196	AFDN	Afadin	0.283717436	0.368178993	0.399734639	0.58962986	0.3259482145	0.4946822495	0.3259482145	0.4946822495	0.658904205334742	0.369489	0	1.51767129713791	0.369720	0	GO:0005912,adherens junction;GO:0030054,cell junction;GO:0044291,cell-cell contact zone;GO:0005911,cell-cell junction;GO:0005829,cytosol;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0046930,pore complex;GO:0070160,tight junction	GO:0051015,actin filament binding;GO:0045296,cadherin binding;GO:0050839,cell adhesion molecule binding;GO:0008022,protein C-terminus binding;GO:0031267,small GTPase binding	GO:0034332,adherens junction organization;GO:0070830,bicellular tight junction assembly;GO:0007155,cell adhesion;GO:0044331,cell-cell adhesion mediated by cadherin;GO:0007267,cell-cell signaling;GO:0090557,establishment of endothelial intestinal barrier;GO:0061951,establishment of protein localization to plasma membrane;GO:0030336,negative regulation of cell migration;GO:0046931,pore complex assembly;GO:0022409,positive regulation of cell-cell adhesion;GO:2000049,positive regulation of cell-cell adhesion mediated by cadherin;GO:0010628,positive regulation of gene expression;GO:0043547,positive regulation of GTPase activity;GO:0032880,regulation of protein localization;GO:0007165,signal transduction	hsa:4301,path:hsa04014,Ras signaling pathway;hsa:4301,path:hsa04015,Rap1 signaling pathway;hsa:4301,path:hsa04024,cAMP signaling pathway;hsa:4301,path:hsa04520,Adherens junction;hsa:4301,path:hsa04530,Tight junction;hsa:4301,path:hsa04670,Leukocyte transendothelial migration
2A5G_HUMAN	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.045553763	0.014674412	0.064665992	0.039511928	0.0301140875	0.05208896	0.0301140875	0.05208896	0.578128023673347	0.296992	0	1.72972068305241	0.297283	0	GO:0000775,chromosome, centromeric region;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000159,protein phosphatase type 2A complex;GO:0016021,integral component of membrane	GO:0072542,protein phosphatase activator activity;GO:0019888,protein phosphatase regulator activity;GO:0008233,peptidase activity	GO:0006977,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0042771,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0008285,negative regulation of cell population proliferation;GO:0051898,negative regulation of protein kinase B signaling;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006470,protein dephosphorylation;GO:0014066,regulation of phosphatidylinositol 3-kinase signaling;GO:0031952,regulation of protein autophosphorylation;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0007165,signal transduction;GO:0016485,protein processing	hsa:5527,path:hsa03015,mRNA surveillance pathway;hsa:5527,path:hsa04071,Sphingolipid signaling pathway;hsa:5527,path:hsa04151,PI3K-Akt signaling pathway;hsa:5527,path:hsa04152,AMPK signaling pathway;hsa:5527,path:hsa04114,Oocyte meiosis;hsa:5527,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:5527,path:hsa04728,Dopaminergic synapse;hsa:5527,path:hsa05165,Human papillomavirus infection
IDI1_HUMAN	Q13907	IDI1	Isopentenyl-diphosphate Delta-isomerase 1	0.160812202	0.078818916	0.085392244	0.022954118	0.119815559	0.054173181	0.119815559	0.054173181	2.21171355988861	0.201328	0	0.45213811505065	0.200768	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005777,peroxisome	GO:0016787,hydrolase activity;GO:0004452,isopentenyl-diphosphate delta-isomerase activity;GO:0000287,magnesium ion binding;GO:0030145,manganese ion binding;GO:0046872,metal ion binding	GO:0006695,cholesterol biosynthetic process;GO:0050992,dimethylallyl diphosphate biosynthetic process;GO:0009240,isopentenyl diphosphate biosynthetic process;GO:0008299,isoprenoid biosynthetic process;GO:0019216,regulation of lipid metabolic process	hsa:3422,path:hsa00900,Terpenoid backbone biosynthesis
MMP14_HUMAN	P50281	MMP14	Matrix metalloproteinase-14	0.272098381	0.218984612	0.307830983	0.289881853	0.2455414965	0.298856418	0.2455414965	0.298856418	0.821603558468669	0.499111	0	1.21713202151148	0.499059	0	GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0031012,extracellular matrix;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0005796,Golgi lumen;GO:0005887,integral component of plasma membrane;GO:0045111,intermediate filament cytoskeleton;GO:0044354,macropinosome;GO:0042470,melanosome;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0004175,endopeptidase activity;GO:0005178,integrin binding;GO:0070006,metalloaminopeptidase activity;GO:0004222,metalloendopeptidase activity;GO:0008270,zinc ion binding	GO:0001525,angiogenesis;GO:0043615,astrocyte cell migration;GO:0048754,branching morphogenesis of an epithelial tube;GO:0048870,cell motility;GO:0035988,chondrocyte proliferation;GO:0030574,collagen catabolic process;GO:0097094,craniofacial suture morphogenesis;GO:0048701,embryonic cranial skeleton morphogenesis;GO:0001958,endochondral ossification;GO:0035987,endodermal cell differentiation;GO:0001935,endothelial cell proliferation;GO:0022617,extracellular matrix disassembly;GO:0030198,extracellular matrix organization;GO:0060322,head development;GO:0030324,lung development;GO:0008584,male gonad development;GO:0051895,negative regulation of focal adhesion assembly;GO:0045746,negative regulation of Notch signaling pathway;GO:0001541,ovarian follicle development;GO:0045579,positive regulation of B cell differentiation;GO:0030307,positive regulation of cell growth;GO:0030335,positive regulation of cell migration;GO:1905523,positive regulation of macrophage migration;GO:0010831,positive regulation of myotube differentiation;GO:0010954,positive regulation of protein processing;GO:0016485,protein processing;GO:0006508,proteolysis;GO:1903076,regulation of protein localization to plasma membrane;GO:0043627,response to estrogen;GO:0001666,response to hypoxia;GO:0009612,response to mechanical stimulus;GO:1990834,response to odorant;GO:0014070,response to organic cyclic compound;GO:0006979,response to oxidative stress;GO:0001501,skeletal system development;GO:0048771,tissue remodeling;GO:0031638,zymogen activation	hsa:4323,path:hsa04668,TNF signaling pathway;hsa:4323,path:hsa04912,GnRH signaling pathway;hsa:4323,path:hsa04928,Parathyroid hormone synthesis, secretion and action
RAGE_HUMAN	Q15109	AGER	Advanced glycosylation end product-specific receptor	0.097030928	0.022756899	0.488952683	20.86081016	0.0598939135	10.6748814215	0.0598939135	10.6748814215	0.00561073337820589	0.000000	-1	178.229819988303	0.000000	1	GO:0016324,apical plasma membrane;GO:0030054,cell junction;GO:0009986,cell surface;GO:0005576,extracellular region;GO:0001650,fibrillar center;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane;GO:0098794,postsynapse;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0050785,advanced glycation end-product receptor activity;GO:0001540,amyloid-beta binding;GO:0042802,identical protein binding;GO:0044877,protein-containing complex binding;GO:0044548,S100 protein binding;GO:0005044,scavenger receptor activity;GO:0038023,signaling receptor activity;GO:0004888,transmembrane signaling receptor activity	GO:0048143,astrocyte activation;GO:0007166,cell surface receptor signaling pathway;GO:1904646,cellular response to amyloid-beta;GO:0010255,glucose mediated signaling pathway;GO:0050930,induction of positive chemotaxis;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0007611,learning or memory;GO:0001774,microglial cell activation;GO:0090647,modulation of age-related behavioral decline;GO:1903523,negative regulation of blood circulation;GO:1904597,negative regulation of connective tissue replacement involved in inflammatory response wound healing;GO:0032693,negative regulation of interleukin-10 production;GO:1900453,negative regulation of long-term synaptic depression;GO:1900272,negative regulation of long-term synaptic potentiation;GO:0031175,neuron projection development;GO:0042104,positive regulation of activated T cell proliferation;GO:1902961,positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:0032722,positive regulation of chemokine production;GO:2001200,positive regulation of dendritic cell differentiation;GO:1904472,positive regulation of endothelin production;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0034116,positive regulation of heterotypic cell-cell adhesion;GO:0032731,positive regulation of interleukin-1 beta production;GO:0032735,positive regulation of interleukin-12 production;GO:0032755,positive regulation of interleukin-6 production;GO:0046330,positive regulation of JNK cascade;GO:0043507,positive regulation of JUN kinase activity;GO:0071639,positive regulation of monocyte chemotactic protein-1 production;GO:2000439,positive regulation of monocyte extravasation;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:1900745,positive regulation of p38MAPK cascade;GO:0001934,positive regulation of protein phosphorylation;GO:0032760,positive regulation of tumor necrosis factor production;GO:0072657,protein localization to membrane;GO:2000514,regulation of CD4-positive, alpha-beta T cell activation;GO:0051101,regulation of DNA binding;GO:0050727,regulation of inflammatory response;GO:1900271,regulation of long-term synaptic potentiation;GO:1901222,regulation of NIK/NF-kappaB signaling;GO:1900744,regulation of p38MAPK cascade;GO:0150003,regulation of spontaneous synaptic transmission;GO:0048167,regulation of synaptic plasticity;GO:0001914,regulation of T cell mediated cytotoxicity;GO:1904645,response to amyloid-beta;GO:0001666,response to hypoxia;GO:0009611,response to wounding;GO:0045056,transcytosis;GO:0150104,transport across blood-brain barrier	hsa:177,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications
GPX4_HUMAN	P36969	GPX4	Phospholipid hydroperoxide glutathione peroxidase	1.212691617	4.042581798	0.175729589	0.039492983	2.6276367075	0.107611286	2.6276367075	0.107611286	24.4178543456864	0.002111	1	0.0409536393264897	0.002068	-1	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0005635,nuclear envelope	GO:0004602,glutathione peroxidase activity;GO:0042802,identical protein binding;GO:0004601,peroxidase activity;GO:0047066,phospholipid-hydroperoxide glutathione peroxidase activity;GO:0008430,selenium binding	GO:0019369,arachidonic acid metabolic process;GO:0019372,lipoxygenase pathway;GO:0042759,long-chain fatty acid biosynthetic process;GO:0007275,multicellular organism development;GO:0110076,negative regulation of ferroptosis;GO:0006644,phospholipid metabolic process;GO:0051258,protein polymerization;GO:0006979,response to oxidative stress;GO:0007283,spermatogenesis;GO:0007568,aging;GO:0006325,chromatin organization;GO:0006749,glutathione metabolic process;GO:0050727,regulation of inflammatory response;GO:0032355,response to estradiol	hsa:2879,path:hsa00480,Glutathione metabolism;hsa:2879,path:hsa04216,Ferroptosis
SOAT1_HUMAN	P35610	SOAT1	Sterol O-acyltransferase 1	0.222748387	0.330737955	0.558432277	0.18281842	0.276743171	0.3706253485	0.276743171	0.3706253485	0.746692508000434	0.443515	0	1.33923936464542	0.443669	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0015485,cholesterol binding;GO:0034736,cholesterol O-acyltransferase activity;GO:0000062,fatty-acyl-CoA binding;GO:0042802,identical protein binding;GO:0008374,O-acyltransferase activity;GO:0004772,sterol O-acyltransferase activity	GO:0033344,cholesterol efflux;GO:0034435,cholesterol esterification;GO:0042632,cholesterol homeostasis;GO:0008203,cholesterol metabolic process;GO:0010878,cholesterol storage;GO:0034383,low-density lipoprotein particle clearance;GO:0010742,macrophage derived foam cell differentiation;GO:0042986,positive regulation of amyloid precursor protein biosynthetic process;GO:0034379,very-low-density lipoprotein particle assembly	hsa:6646,path:hsa00100,Steroid biosynthesis;hsa:6646,path:hsa04979,Cholesterol metabolism
GBB2_HUMAN	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	8.341457576	5.645075738	8.285879813	22.57791168	6.993266657	15.4318957465	6.993266657	15.4318957465	0.453169641104275	0.182670	0	2.2066791534473	0.183006	0	GO:0044297,cell body;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0005834,heterotrimeric G-protein complex;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm;GO:0031982,vesicle	GO:0005246,calcium channel regulator activity;GO:0031682,G-protein gamma-subunit binding;GO:0003924,GTPase activity;GO:0051020,GTPase binding;GO:0044877,protein-containing complex binding	GO:0007186,G protein-coupled receptor signaling pathway;GO:0006457,protein folding;GO:0007165,signal transduction	hsa:2783,path:hsa04014,Ras signaling pathway;hsa:2783,path:hsa04371,Apelin signaling pathway;hsa:2783,path:hsa04151,PI3K-Akt signaling pathway;hsa:2783,path:hsa04062,Chemokine signaling pathway;hsa:2783,path:hsa04926,Relaxin signaling pathway;hsa:2783,path:hsa04724,Glutamatergic synapse;hsa:2783,path:hsa04727,GABAergic synapse;hsa:2783,path:hsa04725,Cholinergic synapse;hsa:2783,path:hsa04728,Dopaminergic synapse;hsa:2783,path:hsa04726,Serotonergic synapse;hsa:2783,path:hsa04723,Retrograde endocannabinoid signaling;hsa:2783,path:hsa04713,Circadian entrainment;hsa:2783,path:hsa05200,Pathways in cancer;hsa:2783,path:hsa05032,Morphine addiction;hsa:2783,path:hsa05034,Alcoholism;hsa:2783,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:2783,path:hsa05163,Human cytomegalovirus infection;hsa:2783,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection
1433E_HUMAN	P62258	YWHAE	14-3-3 protein epsilon	16.78065418	25.97504684	17.21817782	18.74741473	21.37785051	17.982796275	21.37785051	17.982796275	1.18879456693395	0.376907	0	0.841188232024923	0.376594	0	GO:0090724,central region of growth cone;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0005871,kinesin complex;GO:0042470,melanosome;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0045296,cadherin binding;GO:0005246,calcium channel regulator activity;GO:0019899,enzyme binding;GO:0042826,histone deacetylase binding;GO:0042802,identical protein binding;GO:0044325,ion channel binding;GO:0023026,MHC class II protein complex binding;GO:0051219,phosphoprotein binding;GO:0050815,phosphoserine residue binding;GO:0015459,potassium channel regulator activity;GO:0046982,protein heterodimerization activity;GO:0003723,RNA binding;GO:0097110,scaffold protein binding;GO:0031625,ubiquitin protein ligase binding	GO:0034605,cellular response to heat;GO:0097711,ciliary basal body-plasma membrane docking;GO:0000086,G2/M transition of mitotic cell cycle;GO:0035329,hippo signaling;GO:0035556,intracellular signal transduction;GO:0000165,MAPK cascade;GO:0086013,membrane repolarization during cardiac muscle cell action potential;GO:1905913,negative regulation of calcium ion export across plasma membrane;GO:1901020,negative regulation of calcium ion transmembrane transporter activity;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:1902309,negative regulation of peptidyl-serine dephosphorylation;GO:0046827,positive regulation of protein export from nucleus;GO:1900740,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0034504,protein localization to nucleus;GO:1900034,regulation of cellular response to heat;GO:0051480,regulation of cytosolic calcium ion concentration;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0086091,regulation of heart rate by cardiac conduction;GO:0003064,regulation of heart rate by hormone;GO:0060306,regulation of membrane repolarization;GO:0099072,regulation of postsynaptic membrane neurotransmitter receptor levels;GO:1901016,regulation of potassium ion transmembrane transporter activity;GO:0021762,substantia nigra development;GO:0016032,viral process	hsa:7531,path:hsa04390,Hippo signaling pathway;hsa:7531,path:hsa04151,PI3K-Akt signaling pathway;hsa:7531,path:hsa04110,Cell cycle;hsa:7531,path:hsa04114,Oocyte meiosis;hsa:7531,path:hsa04621,NOD-like receptor signaling pathway;hsa:7531,path:hsa04722,Neurotrophin signaling pathway;hsa:7531,path:hsa05203,Viral carcinogenesis;hsa:7531,path:hsa05160,Hepatitis C
PARVA_HUMAN	Q9NVD7	PARVA	Alpha-parvin	0.956039607	1.212701016	1.609382205	4.000831428	1.0843703115	2.8051068165	1.0843703115	2.8051068165	0.386570060406111	0.125453	0	2.58685320572796	0.125773	0	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0030018,Z disc	GO:0003779,actin binding;GO:0045296,cadherin binding;GO:0004860,protein kinase inhibitor activity	GO:0031532,actin cytoskeleton reorganization;GO:0070252,actin-mediated cell contraction;GO:0030031,cell projection assembly;GO:0060271,cilium assembly;GO:0007163,establishment or maintenance of cell polarity;GO:0034113,heterotypic cell-cell adhesion;GO:0003148,outflow tract septum morphogenesis;GO:0050821,protein stabilization;GO:0008360,regulation of cell shape;GO:0071670,smooth muscle cell chemotaxis;GO:0002040,sprouting angiogenesis;GO:0034446,substrate adhesion-dependent cell spreading;GO:0007155,cell adhesion	hsa:55742,path:hsa04510,Focal adhesion
PYRG1_HUMAN	P17812	CTPS1	CTP synthase 1	0.712350843	0.600468604	0.67173309	0.999649659	0.6564097235	0.8356913745	0.6564097235	0.8356913745	0.785469066128312	0.474209	0	1.27312461193302	0.474329	0	GO:0097268,cytoophidium;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane	GO:0005524,ATP binding;GO:0003883,CTP synthase activity;GO:0042802,identical protein binding	GO:0044210,'de novo' CTP biosynthetic process;GO:0042100,B cell proliferation;GO:0006241,CTP biosynthetic process;GO:0006541,glutamine metabolic process;GO:0006139,nucleobase-containing compound metabolic process;GO:0015949,nucleobase-containing small molecule interconversion;GO:0019856,pyrimidine nucleobase biosynthetic process;GO:0042493,response to drug;GO:0042098,T cell proliferation;GO:0006221,pyrimidine nucleotide biosynthetic process	hsa:1503,path:hsa00240,Pyrimidine metabolism
STK10_HUMAN	O94804	STK10	Serine/threonine-protein kinase 10	0.087439706	0.122718923	0.31421937	1.369383323	0.1050793145	0.8418013465	0.1050793145	0.8418013465	0.124826736066524	0.002016	-1	8.01110428351719	0.002039	1	GO:0070062,extracellular exosome;GO:0005886,plasma membrane;GO:0035579,specific granule membrane	GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity	GO:0007049,cell cycle;GO:0071593,lymphocyte aggregation;GO:0043312,neutrophil degranulation;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:2000401,regulation of lymphocyte migration	hsa:6793,path:hsa04914,Progesterone-mediated oocyte maturation
FBX7_HUMAN	Q9Y3I1	FBXO7	F-box only protein 7	0.058275859	0.045443126	0.145744454	1.02998325	0.0518594925	0.587863852	0.0518594925	0.587863852	0.0882168419159748	0.000329	-1	11.335703911873	0.000335	1	GO:0097414,classical Lewy body;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0097409,glial cytoplasmic inclusion;GO:1990037,Lewy body core;GO:1990038,Lewy body corona;GO:0097462,Lewy neurite;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0019005,SCF ubiquitin ligase complex;GO:0000151,ubiquitin ligase complex	GO:0046982,protein heterodimerization activity;GO:0019901,protein kinase binding;GO:0043130,ubiquitin binding;GO:1990756,ubiquitin ligase-substrate adaptor activity;GO:0031625,ubiquitin protein ligase binding;GO:0004842,ubiquitin-protein transferase activity	GO:0000422,autophagy of mitochondrion;GO:0045736,negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:2000134,negative regulation of G1/S transition of mitotic cell cycle;GO:1903208,negative regulation of hydrogen peroxide-induced neuron death;GO:0045620,negative regulation of lymphocyte differentiation;GO:1903204,negative regulation of oxidative stress-induced neuron death;GO:1903599,positive regulation of autophagy of mitochondrion;GO:0043687,post-translational protein modification;GO:0000209,protein polyubiquitination;GO:0006626,protein targeting to mitochondrion;GO:0016567,protein ubiquitination;GO:0040012,regulation of locomotion;GO:0010975,regulation of neuron projection development;GO:0031647,regulation of protein stability;GO:0006511,ubiquitin-dependent protein catabolic process	
MAT2B_HUMAN	Q9NZL9	MAT2B	Methionine adenosyltransferase 2 subunit beta	0.722238842	0.443671608	1.192242513	0.284942986	0.582955225	0.7385927495	0.582955225	0.7385927495	0.789278293612602	0.477153	0	1.26698023763317	0.477269	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0048269,methionine adenosyltransferase complex;GO:0005634,nucleus	GO:0019899,enzyme binding;GO:0048270,methionine adenosyltransferase regulator activity	GO:0032259,methylation;GO:0006730,one-carbon metabolic process;GO:0006556,S-adenosylmethionine biosynthetic process	hsa:27430,path:hsa00270,Cysteine and methionine metabolism
CATD_HUMAN	P07339	CTSD	Cathepsin D	46.51411725	158.4566805	77.98869536	42.06117915	102.485398875	60.024937255	102.485398875	60.024937255	1.7073803582604	0.268042	0	0.585692575858651	0.267545	0	GO:0062023,collagen-containing extracellular matrix;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0043202,lysosomal lumen;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0042470,melanosome;GO:0045121,membrane raft;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen	GO:0004190,aspartic-type endopeptidase activity;GO:0070001,aspartic-type peptidase activity;GO:0008233,peptidase activity	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030574,collagen catabolic process;GO:0042159,lipoprotein catabolic process;GO:0043312,neutrophil degranulation;GO:0043065,positive regulation of apoptotic process;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006508,proteolysis;GO:0070201,regulation of establishment of protein localization	hsa:1509,path:hsa04071,Sphingolipid signaling pathway;hsa:1509,path:hsa04142,Lysosome;hsa:1509,path:hsa04140,Autophagy - animal;hsa:1509,path:hsa04210,Apoptosis;hsa:1509,path:hsa04915,Estrogen signaling pathway;hsa:1509,path:hsa05152,Tuberculosis
S23IP_HUMAN	Q9Y6Y8	SEC23IP	SEC23-interacting protein	0.668864072	0.69595056	0.907209924	0.140331263	0.682407316	0.5237705935	0.682407316	0.5237705935	1.30287443485504	0.347955	0	0.767533672660684	0.347586	0	GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0012507,ER to Golgi transport vesicle membrane;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle	GO:0046872,metal ion binding;GO:0004620,phospholipase activity;GO:0003723,RNA binding	GO:0048208,COPII vesicle coating;GO:0007030,Golgi organization;GO:0006886,intracellular protein transport	
TM245_HUMAN	Q9H330	TMEM245	Transmembrane protein 245	0.202662966	0.145920788	0.102822824	0.509819726	0.174291877	0.306321275	0.174291877	0.306321275	0.568983910764931	0.288615	0	1.75751894048396	0.288911	0	GO:0016021,integral component of membrane			
CATZ_HUMAN	Q9UBR2	CTSZ	Cathepsin Z	3.989901992	7.817933836	8.175659099	4.926865688	5.903917914	6.5512623935	5.903917914	6.5512623935	0.901187826007049	0.468057	0	1.10964659213248	0.467936	0	GO:0099738,cell cortex region;GO:0062023,collagen-containing extracellular matrix;GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0031410,cytoplasmic vesicle;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0005764,lysosome;GO:0005886,plasma membrane;GO:0035580,specific granule lumen	GO:0004180,carboxypeptidase activity;GO:0004197,cysteine-type endopeptidase activity;GO:0008234,cysteine-type peptidase activity	GO:0002003,angiotensin maturation;GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0010757,negative regulation of plasminogen activation;GO:0032091,negative regulation of protein binding;GO:0043312,neutrophil degranulation;GO:0006508,proteolysis;GO:0051603,proteolysis involved in cellular protein catabolic process;GO:1901214,regulation of neuron death	hsa:1522,path:hsa04142,Lysosome;hsa:1522,path:hsa04210,Apoptosis
KLC2_HUMAN	Q9H0B6	KLC2	Kinesin light chain 2	0.050320515	2.55E-05	0.087649599	0.072646698	0.0251730075	0.0801481485	0.0251730075	0.0801481485	0.314080960959441	0.071392	0	3.1838924490846	0.071653	0	GO:0005829,cytosol;GO:0005871,kinesin complex;GO:0016938,kinesin I complex;GO:0016020,membrane;GO:0005874,microtubule;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0032991,protein-containing complex	GO:0045296,cadherin binding;GO:0019894,kinesin binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0032418,lysosome localization;GO:0007018,microtubule-based movement;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	hsa:64837,path:hsa05132,Salmonella infection
INT4_HUMAN	Q96HW7	INTS4	Integrator complex subunit 4	0.059392331	0.021160924	0.108717014	0.128137231	0.0402766275	0.1184271225	0.0402766275	0.1184271225	0.340096311130079	0.089492	0	2.94034356526003	0.089779	0	GO:0032039,integrator complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus		GO:0016180,snRNA processing;GO:0042795,snRNA transcription by RNA polymerase II	
ATD3A_HUMAN	Q9NVI7	ATAD3A	ATPase family AAA domain-containing protein 3A	1.924977462	1.037019722	2.095324677	3.296216543	1.480998592	2.69577061	1.480998592	2.69577061	0.549378566004917	0.270593	0	1.82023846920713	0.270900	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0042645,mitochondrial nucleoid;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0042802,identical protein binding;GO:0008270,zinc ion binding;GO:0000166,nucleotide binding	GO:0140374,antiviral innate immune response;GO:0007005,mitochondrion organization;GO:0043066,negative regulation of apoptotic process;GO:0001558,regulation of cell growth	
PPIH_HUMAN	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	0.904037526	1.833817709	0.083798433	0.01096086	1.3689276175	0.0473796465	1.3689276175	0.0473796465	28.8927359873823	0.001337	1	0.0346107755401465	0.001307	-1	GO:0005737,cytoplasm;GO:0043231,intracellular membrane-bounded organelle;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005681,spliceosomal complex;GO:0071001,U4/U6 snRNP;GO:0046540,U4/U6 x U5 tri-snRNP complex	GO:0016018,cyclosporin A binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity;GO:0043021,ribonucleoprotein complex binding	GO:0000398,mRNA splicing, via spliceosome;GO:0045070,positive regulation of viral genome replication;GO:0006457,protein folding;GO:0000413,protein peptidyl-prolyl isomerization;GO:0065003,protein-containing complex assembly	hsa:10465,path:hsa03040,Spliceosome
AL3A1_HUMAN	P30838	ALDH3A1	Aldehyde dehydrogenase, dimeric NADP-preferring	0.636577273	2.54428032	3.455726794	3.47674221	1.5904287965	3.466234502	1.5904287965	3.466234502	0.458834737113813	0.187742	0	2.17943394236071	0.188077	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005615,extracellular space;GO:0005886,plasma membrane	GO:0004028,3-chloroallyl aldehyde dehydrogenase activity;GO:0008106,alcohol dehydrogenase (NADP+) activity;GO:0004029,aldehyde dehydrogenase (NAD+) activity;GO:0018479,benzaldehyde dehydrogenase (NAD+) activity;GO:0016620,oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0016491,oxidoreductase activity	GO:0007568,aging;GO:0006081,cellular aldehyde metabolic process;GO:0008284,positive regulation of cell population proliferation;GO:0051591,response to cAMP;GO:0042493,response to drug;GO:0051384,response to glucocorticoid;GO:0001666,response to hypoxia;GO:0007584,response to nutrient;GO:0006805,xenobiotic metabolic process	hsa:218,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:218,path:hsa00340,Histidine metabolism;hsa:218,path:hsa00350,Tyrosine metabolism;hsa:218,path:hsa00360,Phenylalanine metabolism;hsa:218,path:hsa00410,beta-Alanine metabolism;hsa:218,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:218,path:hsa00982,Drug metabolism - cytochrome P450;hsa:218,path:hsa05204,Chemical carcinogenesis
F13A_HUMAN	P00488	F13A1	Coagulation factor XIII A chain	2.965320949	30.29412257	13.46025401	27.41959827	16.6297217595	20.43992614	16.6297217595	20.43992614	0.813590110140193	0.495636	0	1.22912015219517	0.495732	0	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0005576,extracellular region;GO:0031093,platelet alpha granule lumen	GO:0046872,metal ion binding;GO:0003810,protein-glutamine gamma-glutamyltransferase activity	GO:0007596,blood coagulation;GO:0072378,blood coagulation, fibrin clot formation;GO:0019221,cytokine-mediated signaling pathway;GO:0018149,peptide cross-linking;GO:0002576,platelet degranulation	hsa:2162,path:hsa04610,Complement and coagulation cascades
MARCS_HUMAN	P29966	MARCKS	Myristoylated alanine-rich C-kinase substrate	0.38920024	0.758745941	0.340348913	0.433254918	0.5739730905	0.3868019155	0.5739730905	0.3868019155	1.48389412642399	0.308361	0	0.673902525923382	0.307924	0	GO:0015629,actin cytoskeleton;GO:0032432,actin filament bundle;GO:0005938,cell cortex;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0042585,germinal vesicle;GO:0005886,plasma membrane	GO:0051015,actin filament binding;GO:0005516,calmodulin binding;GO:0042802,identical protein binding;GO:0005080,protein kinase C binding	GO:0051764,actin crosslink formation;GO:0051017,actin filament bundle assembly;GO:0007015,actin filament organization;GO:0007417,central nervous system development	hsa:4082,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:4082,path:hsa05206,MicroRNAs in cancer
1433T_HUMAN	P27348	YWHAQ	14-3-3 protein theta	34.15446635	61.75903356	27.38919519	26.73216854	47.956749955	27.060681865	47.956749955	27.060681865	1.77219296225594	0.257798	0	0.564272639209126	0.257289	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0032991,protein-containing complex;GO:0045202,synapse	GO:0071889,14-3-3 protein binding;GO:0042802,identical protein binding;GO:0044325,ion channel binding;GO:0008022,protein C-terminus binding;GO:0019904,protein domain specific binding;GO:0047485,protein N-terminus binding	GO:0034766,negative regulation of ion transmembrane transport;GO:0045892,negative regulation of transcription, DNA-templated;GO:1900740,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0006605,protein targeting;GO:0007264,small GTPase mediated signal transduction;GO:0021762,substantia nigra development	hsa:10971,path:hsa04390,Hippo signaling pathway;hsa:10971,path:hsa04151,PI3K-Akt signaling pathway;hsa:10971,path:hsa04110,Cell cycle;hsa:10971,path:hsa04114,Oocyte meiosis;hsa:10971,path:hsa05203,Viral carcinogenesis;hsa:10971,path:hsa05161,Hepatitis B;hsa:10971,path:hsa05160,Hepatitis C
CDK9_HUMAN	P50750	CDK9	Cyclin-dependent kinase 9	2.55E-05	2.55E-05	2.55E-05	2.55E-05	2.55e-005	2.55e-005	2.55e-005	2.55e-005	1	0.433351	0	1	0.433154	0	GO:0008024,cyclin/CDK positive transcription elongation factor complex;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0016592,mediator complex;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0070691,P-TEFb complex;GO:0016605,PML body;GO:0008023,transcription elongation factor complex	GO:0097322,7SK snRNA binding;GO:0005524,ATP binding;GO:0003682,chromatin binding;GO:0004693,cyclin-dependent protein serine/threonine kinase activity;GO:0003677,DNA binding;GO:0004672,protein kinase activity;GO:0019901,protein kinase binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008353,RNA polymerase II CTD heptapeptide repeat kinase activity;GO:0001223,transcription coactivator binding	GO:0008283,cell population proliferation;GO:0071345,cellular response to cytokine stimulus;GO:0006281,DNA repair;GO:0071157,negative regulation of cell cycle arrest;GO:1900364,negative regulation of mRNA polyadenylation;GO:0070816,phosphorylation of RNA polymerase II C-terminal domain;GO:0010613,positive regulation of cardiac muscle hypertrophy;GO:2001168,positive regulation of histone H2B ubiquitination;GO:0033129,positive regulation of histone phosphorylation;GO:1903839,positive regulation of mRNA 3'-UTR binding;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0050434,positive regulation of viral transcription;GO:0006468,protein phosphorylation;GO:0006282,regulation of DNA repair;GO:0031056,regulation of histone modification;GO:0051147,regulation of muscle cell differentiation;GO:0031297,replication fork processing;GO:0042493,response to drug;GO:0042795,snRNA transcription by RNA polymerase II;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter;GO:0006367,transcription initiation from RNA polymerase II promoter	hsa:1025,path:hsa05202,Transcriptional misregulation in cancer
SAHH3_HUMAN	Q96HN2	AHCYL2	Adenosylhomocysteinase 3	2.55E-05	0.086459758	0.125499029	2.55E-05	0.043242629	0.0627622645	0.043242629	0.0627622645	0.688990898344657	0.395516	0	1.45139798276372	0.395720	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0043005,neuron projection	GO:0016787,hydrolase activity;GO:0004013,adenosylhomocysteinase activity	GO:0006730,one-carbon metabolic process;GO:0033353,S-adenosylmethionine cycle	hsa:23382,path:hsa00270,Cysteine and methionine metabolism
HMOX2_HUMAN	P30519	HMOX2	Heme oxygenase 2	0.406641256	0.473784156	0.74276513	0.289228353	0.440212706	0.5159967415	0.440212706	0.5159967415	0.85313078667959	0.486452	0	1.17215322153832	0.486372	0	GO:0005789,endoplasmic reticulum membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0035579,specific granule membrane;GO:0016021,integral component of membrane	GO:0020037,heme binding;GO:0004392,heme oxygenase (decyclizing) activity;GO:0046872,metal ion binding	GO:0006879,cellular iron ion homeostasis;GO:0042167,heme catabolic process;GO:0006788,heme oxidation;GO:0055072,iron ion homeostasis;GO:0043312,neutrophil degranulation;GO:0001666,response to hypoxia;GO:0006979,response to oxidative stress	hsa:3163,path:hsa00860,Porphyrin and chlorophyll metabolism;hsa:3163,path:hsa04978,Mineral absorption
RTN1_HUMAN	Q16799	RTN1	Reticulon-1	0.015089108	0.164996614	0.094641146	0.117428219	0.090042861	0.1060346825	0.090042861	0.1060346825	0.849183105725808	0.488011	0	1.17760232540812	0.487934	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0000139,Golgi membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016021,integral component of membrane		GO:1902430,negative regulation of amyloid-beta formation;GO:0030182,neuron differentiation	
RCN1_HUMAN	Q15293	RCN1	Reticulocalbin-1	0.710821095	0.277621512	0.926733671	0.627154842	0.4942213035	0.7769442565	0.4942213035	0.7769442565	0.636109089378409	0.349374	0	1.5720573981692	0.349622	0	GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen	GO:0005509,calcium ion binding	GO:0043010,camera-type eye development;GO:0044267,cellular protein metabolic process;GO:0001701,in utero embryonic development;GO:0043687,post-translational protein modification	
DPP9_HUMAN	Q86TI2	DPP9	Dipeptidyl peptidase 9	0.607247431	0.448706858	0.611288629	0.557895837	0.5279771445	0.584592233	0.5279771445	0.584592233	0.903154566030644	0.467326	0	1.10723018806735	0.467203	0	GO:0031252,cell leading edge;GO:0005829,cytosol;GO:0005874,microtubule;GO:0005634,nucleus	GO:0004177,aminopeptidase activity;GO:0008239,dipeptidyl-peptidase activity;GO:0042802,identical protein binding;GO:0008236,serine-type peptidase activity	GO:0006508,proteolysis	
RD23B_HUMAN	P54727	RAD23B	UV excision repair protein RAD23 homolog B	5.850600674	3.68057557	5.987430782	13.43249286	4.765588122	9.709961821	4.765588122	9.709961821	0.490793703399877	0.216711	0	2.03751595237	0.217042	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000502,proteasome complex;GO:0071942,XPC complex	GO:0003684,damaged DNA binding;GO:0031593,polyubiquitin modification-dependent protein binding;GO:0070628,proteasome binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003697,single-stranded DNA binding;GO:0043130,ubiquitin binding	GO:0098761,cellular response to interleukin-7;GO:0048568,embryonic organ development;GO:0070911,global genome nucleotide-excision repair;GO:0006289,nucleotide-excision repair;GO:0000715,nucleotide-excision repair, DNA damage recognition;GO:0000717,nucleotide-excision repair, DNA duplex unwinding;GO:0006294,nucleotide-excision repair, preincision complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0006457,protein folding;GO:0032434,regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0007283,spermatogenesis	hsa:5887,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:5887,path:hsa03420,Nucleotide excision repair
DSC1_HUMAN	Q08554	DSC1	Desmocollin-1	0.513372852	0.94646757	0.337173192	1.034543394	0.729920211	0.685858293	0.729920211	0.685858293	1.06424347193831	0.412808	0	0.939634610282082	0.412567	0	GO:0005911,cell-cell junction;GO:0001533,cornified envelope;GO:0030057,desmosome;GO:0070062,extracellular exosome;GO:0101003,ficolin-1-rich granule membrane;GO:0005921,gap junction;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0005509,calcium ion binding	GO:0098609,cell-cell adhesion;GO:0070268,cornification;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0031424,keratinization;GO:0043312,neutrophil degranulation	
CRYL1_HUMAN	Q9Y2S2	CRYL1	Lambda-crystallin homolog	0.249687369	0.277132354	0.354590702	0.380624324	0.2634098615	0.367607513	0.2634098615	0.367607513	0.716551898927049	0.418774	0	1.39557232560179	0.418955	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0050104,L-gulonate 3-dehydrogenase activity;GO:0070403,NAD+ binding;GO:0016616,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0042803,protein homodimerization activity	GO:0006631,fatty acid metabolic process;GO:0019640,glucuronate catabolic process to xylulose 5-phosphate	hsa:51084,path:hsa00040,Pentose and glucuronate interconversions
RLA2_HUMAN	P05387	RPLP2	60S acidic ribosomal protein P2	6.767828769	5.994971693	0.575954304	0.112751239	6.381400231	0.3443527715	6.381400231	0.3443527715	18.5315779605973	0.004287	1	0.053961945503305	0.004212	-1	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane	GO:0003735,structural constituent of ribosome	GO:0002182,cytoplasmic translational elongation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6181,path:hsa03010,Ribosome
MPRD_HUMAN	P20645	M6PR	Cation-dependent mannose-6-phosphate receptor	0.441549335	0.796031877	0.741529322	0.836652101	0.618790606	0.7890907115	0.618790606	0.7890907115	0.784181839910049	0.473211	0	1.27521443255394	0.473332	0	GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0005768,endosome;GO:0005887,integral component of plasma membrane;GO:0005770,late endosome;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0005802,trans-Golgi network;GO:0032588,trans-Golgi network membrane;GO:0030133,transport vesicle;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane	GO:0019904,protein domain specific binding;GO:1905394,retromer complex binding;GO:0004888,transmembrane signaling receptor activity	GO:0008333,endosome to lysosome transport;GO:0007041,lysosomal transport;GO:0061024,membrane organization;GO:0006622,protein targeting to lysosome;GO:0006898,receptor-mediated endocytosis;GO:0033299,secretion of lysosomal enzymes	hsa:4074,path:hsa04145,Phagosome;hsa:4074,path:hsa04142,Lysosome;hsa:4074,path:hsa05132,Salmonella infection
PDS5A_HUMAN	Q29RF7	PDS5A	Sister chromatid cohesion protein PDS5 homolog A	0.390513465	0.233506634	0.366201522	0.190254059	0.3120100495	0.2782277905	0.3120100495	0.2782277905	1.12141942736666	0.395722	0	0.891727016312018	0.395446	0	GO:0000785,chromatin;GO:0005694,chromosome;GO:0000775,chromosome, centromeric region;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane		GO:0051301,cell division;GO:0006281,DNA repair;GO:0007064,mitotic sister chromatid cohesion;GO:0008156,negative regulation of DNA replication	
HV323_HUMAN	P01764	IGHV3-23	Immunoglobulin heavy variable 3-23	0.627609663	0.302603269	0.457205729	0.788888828	0.465106466	0.6230472785	0.465106466	0.6230472785	0.746502684547076	0.443361	0	1.33957991136593	0.443516	0	GO:0009897,external side of plasma membrane;GO:0042571,immunoglobulin complex, circulating;GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane;GO:0019814,immunoglobulin complex	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006956,complement activation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
DEST_HUMAN	P60981	DSTN	Destrin	9.116204155	14.78639972	1.087723319	0.670926721	11.9513019375	0.87932502	11.9513019375	0.87932502	13.5914498799318	0.008960	1	0.0735756677053663	0.008830	-1	GO:0015629,actin cytoskeleton;GO:0030864,cortical actin cytoskeleton;GO:0005737,cytoplasm;GO:0070062,extracellular exosome	GO:0051015,actin filament binding;GO:0003779,actin binding	GO:0030042,actin filament depolymerization;GO:0030043,actin filament fragmentation;GO:0051014,actin filament severing;GO:0008154,actin polymerization or depolymerization;GO:0048870,cell motility;GO:0030836,positive regulation of actin filament depolymerization	
SH3L3_HUMAN	Q9H299	SH3BGRL3	SH3 domain-binding glutamic acid-rich-like protein 3	4.835516275	8.21363486	2.844751997	3.630927284	6.5245755675	3.2378396405	6.5245755675	3.2378396405	2.01510151580344	0.224101	0	0.496252914385454	0.223557	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0016604,nuclear body	GO:0015035,protein disulfide oxidoreductase activity		
UB2L3_HUMAN	P68036	UBE2L3	Ubiquitin-conjugating enzyme E2 L3	1.363839177	8.344263101	0.191448472	0.105900324	4.854051139	0.148674398	4.854051139	0.148674398	32.6488703118879	0.000948	1	0.0306289311221861	0.000926	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000151,ubiquitin ligase complex	GO:0005524,ATP binding;GO:0019899,enzyme binding;GO:0003723,RNA binding;GO:0003713,transcription coactivator activity;GO:0061631,ubiquitin conjugating enzyme activity;GO:0031625,ubiquitin protein ligase binding;GO:0097027,ubiquitin-protein transferase activator activity;GO:0004842,ubiquitin-protein transferase activity	GO:0044770,cell cycle phase transition;GO:0008283,cell population proliferation;GO:0006464,cellular protein modification process;GO:0071385,cellular response to glucocorticoid stimulus;GO:0071383,cellular response to steroid hormone stimulus;GO:1903955,positive regulation of protein targeting to mitochondrion;GO:0031398,positive regulation of protein ubiquitination;GO:0051443,positive regulation of ubiquitin-protein transferase activity;GO:0070979,protein K11-linked ubiquitination;GO:0000209,protein polyubiquitination;GO:0016567,protein ubiquitination;GO:0006355,regulation of transcription, DNA-templated;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:7332,path:hsa04120,Ubiquitin mediated proteolysis;hsa:7332,path:hsa05012,Parkinson disease
NAGA_HUMAN	Q9Y303	AMDHD2	N-acetylglucosamine-6-phosphate deacetylase	0.056781386	0.045442762	0.181148697	0.063459865	0.051112074	0.122304281	0.051112074	0.122304281	0.417909116362002	0.151734	0	2.39286476616073	0.152065	0	GO:0005829,cytosol;GO:0005634,nucleus	GO:0046872,metal ion binding;GO:0047419,N-acetylgalactosamine-6-phosphate deacetylase activity;GO:0008448,N-acetylglucosamine-6-phosphate deacetylase activity	GO:0005975,carbohydrate metabolic process;GO:0006046,N-acetylglucosamine catabolic process;GO:0019262,N-acetylneuraminate catabolic process;GO:0006048,UDP-N-acetylglucosamine biosynthetic process;GO:0006044,N-acetylglucosamine metabolic process	hsa:51005,path:hsa00520,Amino sugar and nucleotide sugar metabolism
ITB5_HUMAN	P18084	ITGB5	Integrin beta-5	0.094508148	0.583800321	0.143918233	0.510122264	0.3391542345	0.3270202485	0.3391542345	0.3270202485	1.03710469322819	0.421305	0	0.964222808487446	0.421082	0	GO:0009986,cell surface;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0034684,integrin alphav-beta5 complex;GO:0045335,phagocytic vesicle;GO:0005886,plasma membrane;GO:0043235,receptor complex;GO:0008305,integrin complex;GO:0030054,cell junction	GO:0005178,integrin binding;GO:0038023,signaling receptor activity;GO:0001618,virus receptor activity	GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0033627,cell adhesion mediated by integrin;GO:0016477,cell migration;GO:0007160,cell-matrix adhesion;GO:0035987,endodermal cell differentiation;GO:0090136,epithelial cell-cell adhesion;GO:0030198,extracellular matrix organization;GO:0007229,integrin-mediated signaling pathway;GO:0006936,muscle contraction;GO:0043149,stress fiber assembly;GO:0007179,transforming growth factor beta receptor signaling pathway;GO:0007155,cell adhesion	hsa:3693,path:hsa04151,PI3K-Akt signaling pathway;hsa:3693,path:hsa04512,ECM-receptor interaction;hsa:3693,path:hsa04145,Phagosome;hsa:3693,path:hsa04510,Focal adhesion;hsa:3693,path:hsa04810,Regulation of actin cytoskeleton;hsa:3693,path:hsa05205,Proteoglycans in cancer;hsa:3693,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:3693,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:3693,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:3693,path:hsa05165,Human papillomavirus infection
PON2_HUMAN	Q15165	PON2	Serum paraoxonase/arylesterase 2	0.319735836	0.784132639	1.100727171	1.101616757	0.5519342375	1.101171964	0.5519342375	1.101171964	0.501224382334529	0.226263	0	1.99511443426265	0.226591	0	GO:0005576,extracellular region;GO:0005886,plasma membrane;GO:0016021,integral component of membrane;GO:0005764,lysosome;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0102007,acyl-L-homoserine-lactone lactonohydrolase activity;GO:0004064,arylesterase activity;GO:0042802,identical protein binding;GO:0046872,metal ion binding	GO:0019439,aromatic compound catabolic process;GO:0019372,lipoxygenase pathway;GO:0009636,response to toxic substance;GO:0006979,response to oxidative stress	
IF16_HUMAN	Q16666	IFI16	Gamma-interferon-inducible protein 16	1.549744901	2.624219726	2.469296894	1.989525042	2.0869823135	2.229410968	2.0869823135	2.229410968	0.936113773304088	0.455331	0	1.06824622019012	0.455182	0	GO:0005829,cytosol;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0001227,DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003690,double-stranded DNA binding;GO:0042802,identical protein binding;GO:0003723,RNA binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008134,transcription factor binding	GO:0097202,activation of cysteine-type endopeptidase activity;GO:0002218,activation of innate immune response;GO:0006914,autophagy;GO:0042149,cellular response to glucose starvation;GO:0035458,cellular response to interferon-beta;GO:0071479,cellular response to ionizing radiation;GO:0051607,defense response to virus;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0072332,intrinsic apoptotic signaling pathway by p53 class mediator;GO:0042771,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0030224,monocyte differentiation;GO:0030099,myeloid cell differentiation;GO:2000117,negative regulation of cysteine-type endopeptidase activity;GO:0043392,negative regulation of DNA binding;GO:0045824,negative regulation of innate immune response;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0045071,negative regulation of viral genome replication;GO:0001819,positive regulation of cytokine production;GO:0032731,positive regulation of interleukin-1 beta production;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0032481,positive regulation of type I interferon production;GO:0010506,regulation of autophagy;GO:0040029,regulation of gene expression, epigenetic	hsa:3428,path:hsa04621,NOD-like receptor signaling pathway
LAMA3_HUMAN	Q16787	LAMA3	Laminin subunit alpha-3	0.620311165	0.264824137	0.786826654	7.944053613	0.442567651	4.3654401335	0.442567651	4.3654401335	0.101379846582656	0.000703	-1	9.86389340394877	0.000712	1	GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005610,laminin-5 complex;GO:0016020,membrane	GO:0005201,extracellular matrix structural constituent;GO:0005178,integrin binding;GO:0005198,structural molecule activity;GO:0005102,signaling receptor binding	GO:0009887,animal organ morphogenesis;GO:0007411,axon guidance;GO:0016477,cell migration;GO:0098609,cell-cell adhesion;GO:0030199,collagen fibril organization;GO:0035987,endodermal cell differentiation;GO:0008544,epidermis development;GO:0030198,extracellular matrix organization;GO:0031581,hemidesmosome assembly;GO:0007229,integrin-mediated signaling pathway;GO:0001738,morphogenesis of a polarized epithelium;GO:0030155,regulation of cell adhesion;GO:0030334,regulation of cell migration;GO:0045995,regulation of embryonic development;GO:0009888,tissue development;GO:0007155,cell adhesion	hsa:3909,path:hsa04151,PI3K-Akt signaling pathway;hsa:3909,path:hsa04512,ECM-receptor interaction;hsa:3909,path:hsa04510,Focal adhesion;hsa:3909,path:hsa05200,Pathways in cancer;hsa:3909,path:hsa05222,Small cell lung cancer;hsa:3909,path:hsa05165,Human papillomavirus infection;hsa:3909,path:hsa05146,Amoebiasis;hsa:3909,path:hsa05145,Toxoplasmosis
PSMD6_HUMAN	Q15008	PSMD6	26S proteasome non-ATPase regulatory subunit 6	3.0302674	2.927318033	4.043549774	9.980552093	2.9787927165	7.0120509335	2.9787927165	7.0120509335	0.424810479095189	0.157691	0	2.35399089525738	0.158024	0	GO:0005829,cytosol;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005654,nucleoplasm;GO:0022624,proteasome accessory complex;GO:0000502,proteasome complex;GO:0005838,proteasome regulatory particle;GO:0034774,secretory granule lumen	GO:0016887,ATPase activity;GO:0030234,enzyme regulator activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0043312,neutrophil degranulation;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006508,proteolysis;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:9861,path:hsa03050,Proteasome;hsa:9861,path:hsa05169,Epstein-Barr virus infection
E41L1_HUMAN	Q9H4G0	EPB41L1	Band 4.1-like protein 1	0.225089806	0.363885181	0.233946052	1.348124095	0.2944874935	0.7910350735	0.2944874935	0.7910350735	0.37228120896968	0.113965	0	2.68614148634465	0.114276	0	GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005886,plasma membrane	GO:0003779,actin binding;GO:0005198,structural molecule activity;GO:0008092,cytoskeletal protein binding	GO:0031032,actomyosin structure organization;GO:0030866,cortical actin cytoskeleton organization	
GSK3B_HUMAN	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.073136987	0.117144078	0.184468683	2.55E-05	0.0951405325	0.0922470915	0.0951405325	0.0922470915	1.03136620302007	0.423135	0	0.969587714889025	0.422916	0	GO:0030424,axon;GO:0030877,beta-catenin destruction complex;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0098978,glutamatergic synapse;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0098794,postsynapse;GO:1990909,Wnt signalosome;GO:0016021,integral component of membrane	GO:0005524,ATP binding;GO:0008013,beta-catenin binding;GO:0034452,dynactin binding;GO:0016301,kinase activity;GO:0051059,NF-kappaB binding;GO:0002039,p53 binding;GO:0002020,protease binding;GO:0034236,protein kinase A catalytic subunit binding;GO:0004672,protein kinase activity;GO:0019901,protein kinase binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0001085,RNA polymerase II transcription factor binding;GO:0048156,tau protein binding;GO:0050321,tau-protein kinase activity;GO:0031625,ubiquitin protein ligase binding	GO:1904885,beta-catenin destruction complex assembly;GO:1904886,beta-catenin destruction complex disassembly;GO:1904646,cellular response to amyloid-beta;GO:0036016,cellular response to interleukin-3;GO:0007623,circadian rhythm;GO:0007212,dopamine receptor signaling pathway;GO:0001837,epithelial to mesenchymal transition;GO:0006983,ER overload response;GO:0030010,establishment of cell polarity;GO:0060079,excitatory postsynaptic potential;GO:0097191,extrinsic apoptotic signaling pathway;GO:0097192,extrinsic apoptotic signaling pathway in absence of ligand;GO:0005977,glycogen metabolic process;GO:0021766,hippocampus development;GO:0008286,insulin receptor signaling pathway;GO:0035556,intracellular signal transduction;GO:0030011,maintenance of cell polarity;GO:0043066,negative regulation of apoptotic process;GO:0070885,negative regulation of calcineurin-NFAT signaling cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:1904339,negative regulation of dopaminergic neuron differentiation;GO:1902042,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2000466,negative regulation of glycogen (starch) synthase activity;GO:0045719,negative regulation of glycogen biosynthetic process;GO:1901215,negative regulation of neuron death;GO:0032515,negative regulation of phosphoprotein phosphatase activity;GO:1901984,negative regulation of protein acetylation;GO:0032091,negative regulation of protein binding;GO:1900181,negative regulation of protein localization to nucleus;GO:0031333,negative regulation of protein-containing complex assembly;GO:2000077,negative regulation of type B pancreatic cell development;GO:0031175,neuron projection development;GO:0106027,neuron projection organization;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:0010508,positive regulation of autophagy;GO:0001954,positive regulation of cell-matrix adhesion;GO:0010628,positive regulation of gene expression;GO:0043547,positive regulation of GTPase activity;GO:1901030,positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:0010822,positive regulation of mitochondrion organization;GO:1901216,positive regulation of neuron death;GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032092,positive regulation of protein binding;GO:0045732,positive regulation of protein catabolic process;GO:0046827,positive regulation of protein export from nucleus;GO:1904781,positive regulation of protein localization to centrosome;GO:0031334,positive regulation of protein-containing complex assembly;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:0030516,regulation of axon extension;GO:0050770,regulation of axonogenesis;GO:1900034,regulation of cellular response to heat;GO:0042752,regulation of circadian rhythm;GO:0048814,regulation of dendrite morphogenesis;GO:1900271,regulation of long-term synaptic potentiation;GO:0150101,regulation of microtubule anchoring at centrosome;GO:0070507,regulation of microtubule cytoskeleton organization;GO:0032886,regulation of microtubule-based process;GO:0010975,regulation of neuron projection development;GO:2000300,regulation of synaptic vesicle exocytosis;GO:0007165,signal transduction;GO:0071109,superior temporal gyrus development;GO:0019082,viral protein processing;GO:0016055,Wnt signaling pathway;GO:0009968,negative regulation of signal transduction;GO:0048511,rhythmic process	hsa:2932,path:hsa04012,ErbB signaling pathway;hsa:2932,path:hsa04310,Wnt signaling pathway;hsa:2932,path:hsa04340,Hedgehog signaling pathway;hsa:2932,path:hsa04390,Hippo signaling pathway;hsa:2932,path:hsa04151,PI3K-Akt signaling pathway;hsa:2932,path:hsa04150,mTOR signaling pathway;hsa:2932,path:hsa04110,Cell cycle;hsa:2932,path:hsa04510,Focal adhesion;hsa:2932,path:hsa04550,Signaling pathways regulating pluripotency of stem cells;hsa:2932,path:hsa04660,T cell receptor signaling pathway;hsa:2932,path:hsa04657,IL-17 signaling pathway;hsa:2932,path:hsa04662,B cell receptor signaling pathway;hsa:2932,path:hsa04062,Chemokine signaling pathway;hsa:2932,path:hsa04910,Insulin signaling pathway;hsa:2932,path:hsa04917,Prolactin signaling pathway;hsa:2932,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:2932,path:hsa04919,Thyroid hormone signaling pathway;hsa:2932,path:hsa04916,Melanogenesis;hsa:2932,path:hsa04728,Dopaminergic synapse;hsa:2932,path:hsa04722,Neurotrophin signaling pathway;hsa:2932,path:hsa04360,Axon guidance;hsa:2932,path:hsa05200,Pathways in cancer;hsa:2932,path:hsa05210,Colorectal cancer;hsa:2932,path:hsa05225,Hepatocellular carcinoma;hsa:2932,path:hsa05226,Gastric cancer;hsa:2932,path:hsa05217,Basal cell carcinoma;hsa:2932,path:hsa05215,Prostate cancer;hsa:2932,path:hsa05213,Endometrial cancer;hsa:2932,path:hsa05224,Breast cancer;hsa:2932,path:hsa05010,Alzheimer disease;hsa:2932,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:2932,path:hsa04931,Insulin resistance;hsa:2932,path:hsa04934,Cushing syndrome;hsa:2932,path:hsa05131,Shigellosis;hsa:2932,path:hsa05135,Yersinia infection;hsa:2932,path:hsa05162,Measles;hsa:2932,path:hsa05160,Hepatitis C;hsa:2932,path:hsa05163,Human cytomegalovirus infection;hsa:2932,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:2932,path:hsa05165,Human papillomavirus infection;hsa:2932,path:hsa01521,EGFR tyrosine kinase inhibitor resistance
PSME3_HUMAN	P61289	PSME3	Proteasome activator complex subunit 3	0.683755832	0.404866235	0.883388062	0.430298052	0.5443110335	0.656843057	0.5443110335	0.656843057	0.828677456051728	0.496228	0	1.20674213193218	0.496170	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0008537,proteasome activator complex;GO:0000502,proteasome complex	GO:0061133,endopeptidase activator activity;GO:0042802,identical protein binding;GO:0097371,MDM2/MDM4 family protein binding;GO:0002039,p53 binding	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0006915,apoptotic process;GO:0007049,cell cycle;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:2001237,negative regulation of extrinsic apoptotic signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0010950,positive regulation of endopeptidase activity;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:2000045,regulation of G1/S transition of mitotic cell cycle;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061136,regulation of proteasomal protein catabolic process;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:10197,path:hsa03050,Proteasome;hsa:10197,path:hsa04612,Antigen processing and presentation;hsa:10197,path:hsa05160,Hepatitis C
FBRL_HUMAN	P22087	FBL	rRNA 2'-O-methyltransferase fibrillarin	1.696148331	2.239351017	1.908706993	0.66676739	1.967749674	1.2877371915	1.967749674	1.2877371915	1.52806775092665	0.299713	0	0.654421244996227	0.299262	0	GO:0031428,box C/D RNP complex;GO:0015030,Cajal body;GO:0005694,chromosome;GO:0001651,dense fibrillar component;GO:0070062,extracellular exosome;GO:0001650,fibrillar center;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032040,small-subunit processome	GO:0051117,ATPase binding;GO:1990259,histone-glutamine methyltransferase activity;GO:0003723,RNA binding;GO:0008649,rRNA methyltransferase activity;GO:0001094,TFIID-class transcription factor complex binding;GO:0008168,methyltransferase activity	GO:0000494,box C/D RNA 3'-end processing;GO:1990258,histone glutamine methylation;GO:0001649,osteoblast differentiation;GO:0031167,rRNA methylation;GO:0006364,rRNA processing;GO:0048254,snoRNA localization;GO:0032259,methylation	hsa:2091,path:hsa03008,Ribosome biogenesis in eukaryotes
LMAN2_HUMAN	Q12907	LMAN2	Vesicular integral-membrane protein VIP36	13.13192317	9.763869961	15.7174692	11.23952653	11.4478965655	13.478497865	11.4478965655	13.478497865	0.849345133275354	0.487947	0	1.17737767701532	0.487870	0	GO:0009986,cell surface;GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005887,integral component of plasma membrane;GO:0016020,membrane	GO:0030246,carbohydrate binding;GO:0031072,heat shock protein binding;GO:0005537,mannose binding;GO:0046872,metal ion binding	GO:0007029,endoplasmic reticulum organization;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030,Golgi organization;GO:0050766,positive regulation of phagocytosis;GO:0015031,protein transport;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	hsa:10960,path:hsa04141,Protein processing in endoplasmic reticulum
DSG3_HUMAN	P32926	DSG3	Desmoglein-3	0.311468515	0.247126954	0.439713507	0.393473967	0.2792977345	0.416593737	0.2792977345	0.416593737	0.670431909301603	0.379536	0	1.49157578290346	0.379756	0	GO:0005911,cell-cell junction;GO:0001533,cornified envelope;GO:0005829,cytosol;GO:0030057,desmosome;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005886,plasma membrane	GO:0005509,calcium ion binding	GO:0098609,cell-cell adhesion;GO:0070268,cornification;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0031424,keratinization	
TAGL2_HUMAN	P37802	TAGLN2	Transgelin-2	135.8402491	170.4935338	17.44880378	4.85200413	153.16689145	11.150403955	153.16689145	11.150403955	13.7364432775835	0.008746	1	0.072799048472169	0.008618	-1	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0031982,vesicle	GO:0045296,cadherin binding	GO:0030855,epithelial cell differentiation;GO:0002576,platelet degranulation	
LOX5_HUMAN	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	13.59233524	13.17797974	11.96076244	9.144887978	13.38515749	10.552825209	13.38515749	10.552825209	1.26839564049487	0.356347	0	0.78839753786117	0.355993	0	GO:0005829,cytosol;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0005635,nuclear envelope;GO:0005641,nuclear envelope lumen;GO:0016363,nuclear matrix;GO:0031965,nuclear membrane;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm;GO:0034774,secretory granule lumen;GO:0005737,cytoplasm	GO:0004052,arachidonate 12(S)-lipoxygenase activity;GO:0004051,arachidonate 5-lipoxygenase activity;GO:0036403,arachidonate 8(S)-lipoxygenase activity;GO:0016787,hydrolase activity;GO:0005506,iron ion binding;GO:0016702,oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	GO:0019369,arachidonic acid metabolic process;GO:0019221,cytokine-mediated signaling pathway;GO:0036336,dendritic cell migration;GO:0042593,glucose homeostasis;GO:0051122,hepoxilin biosynthetic process;GO:0006959,humoral immune response;GO:0035655,interleukin-18-mediated signaling pathway;GO:0002232,leukocyte chemotaxis involved in inflammatory response;GO:0002523,leukocyte migration involved in inflammatory response;GO:1901753,leukotriene A4 biosynthetic process;GO:0019370,leukotriene biosynthetic process;GO:0006691,leukotriene metabolic process;GO:0002540,leukotriene production involved in inflammatory response;GO:0043651,linoleic acid metabolic process;GO:0034440,lipid oxidation;GO:2001301,lipoxin biosynthetic process;GO:0019372,lipoxygenase pathway;GO:0042759,long-chain fatty acid biosynthetic process;GO:0016525,negative regulation of angiogenesis;GO:0001937,negative regulation of endothelial cell proliferation;GO:0050728,negative regulation of inflammatory response;GO:1903573,negative regulation of response to endoplasmic reticulum stress;GO:1903671,negative regulation of sprouting angiogenesis;GO:0061044,negative regulation of vascular wound healing;GO:0061045,negative regulation of wound healing;GO:0043312,neutrophil degranulation;GO:0030501,positive regulation of bone mineralization;GO:1904999,positive regulation of leukocyte adhesion to arterial endothelial cell;GO:1900407,regulation of cellular response to oxidative stress;GO:1900015,regulation of cytokine production involved in inflammatory response;GO:0045598,regulation of fat cell differentiation;GO:0050727,regulation of inflammatory response;GO:0106014,regulation of inflammatory response to wounding;GO:0050796,regulation of insulin secretion;GO:1903426,regulation of reactive oxygen species biosynthetic process	hsa:240,path:hsa00590,Arachidonic acid metabolism;hsa:240,path:hsa04664,Fc epsilon RI signaling pathway;hsa:240,path:hsa04913,Ovarian steroidogenesis;hsa:240,path:hsa04726,Serotonergic synapse;hsa:240,path:hsa05145,Toxoplasmosis
TCRG1_HUMAN	O14776	TCERG1	Transcription elongation regulator 1	0.451804541	0.25825514	0.522625349	0.237295392	0.3550298405	0.3799603705	0.3550298405	0.3799603705	0.934386499394152	0.455948	0	1.07022094245624	0.455800	0	GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0042802,identical protein binding;GO:0003723,RNA binding;GO:0070063,RNA polymerase binding;GO:0001103,RNA polymerase II repressing transcription factor binding;GO:0003713,transcription coactivator activity;GO:0003712,transcription coregulator activity;GO:0003714,transcription corepressor activity;GO:0003711,transcription elongation regulator activity;GO:0044390,ubiquitin-like protein conjugating enzyme binding	GO:0006397,mRNA processing;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0034244,negative regulation of transcription elongation from RNA polymerase II promoter;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0032968,positive regulation of transcription elongation from RNA polymerase II promoter;GO:0008380,RNA splicing	hsa:10915,path:hsa03040,Spliceosome
MET7A_HUMAN	Q9H8H3	METTL7A	Methyltransferase-like protein 7A	0.865622612	4.064127782	3.417487072	4.823141856	2.464875197	4.120314464	2.464875197	4.120314464	0.598225018632947	0.315312	0	1.67161179966224	0.315589	0	GO:0005783,endoplasmic reticulum;GO:0005576,extracellular region;GO:0005811,lipid droplet;GO:0016020,membrane;GO:1904724,tertiary granule lumen;GO:0016021,integral component of membrane	GO:0008168,methyltransferase activity	GO:0032259,methylation;GO:0043312,neutrophil degranulation	
RS16_HUMAN	P62249	RPS16	40S ribosomal protein S16	10.84326483	18.73866838	6.598688238	6.118150505	14.790966605	6.3584193715	14.790966605	6.3584193715	2.32620180280916	0.189586	0	0.429885317255099	0.189020	0	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0015935,small ribosomal subunit;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000462,maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0042274,ribosomal small subunit biogenesis;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription;GO:1990830,cellular response to leukemia inhibitory factor	hsa:6217,path:hsa03010,Ribosome
FLNC_HUMAN	Q14315	FLNC	Filamin-C	2.235179371	0.814405296	1.572001057	2.81955991	1.5247923335	2.1957804835	1.5247923335	2.1957804835	0.694419294168027	0.400142	0	1.44005215350199	0.400343	0	GO:0043034,costamere;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005886,plasma membrane;GO:0042383,sarcolemma;GO:0016528,sarcoplasm;GO:0030018,Z disc	GO:0003779,actin binding;GO:0030506,ankyrin binding;GO:0008092,cytoskeletal protein binding;GO:0042802,identical protein binding	GO:0034329,cell junction assembly;GO:0048747,muscle fiber development	hsa:2318,path:hsa04010,MAPK signaling pathway;hsa:2318,path:hsa04510,Focal adhesion;hsa:2318,path:hsa05205,Proteoglycans in cancer;hsa:2318,path:hsa05132,Salmonella infection
ADDB_HUMAN	P35612	ADD2	Beta-adducin	0.034717466	0.071284963	0.584868523	1.067640063	0.0530012145	0.826254293	0.0530012145	0.826254293	0.0641463710978867	0.000049	-1	15.5893464101658	0.000050	1	GO:0031410,cytoplasmic vesicle;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0008290,F-actin capping protein complex;GO:0005886,plasma membrane;GO:0044853,plasma membrane raft;GO:0014069,postsynaptic density	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0005516,calmodulin binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0019901,protein kinase binding;GO:0030507,spectrin binding;GO:0005200,structural constituent of cytoskeleton	GO:0030036,actin cytoskeleton organization;GO:0051017,actin filament bundle assembly;GO:0051016,barbed-end actin filament capping;GO:0030097,hemopoiesis;GO:0050900,leukocyte migration;GO:0050901,leukocyte tethering or rolling;GO:0032092,positive regulation of protein binding;GO:0065003,protein-containing complex assembly;GO:0007416,synapse assembly;GO:0055085,transmembrane transport	
SAP3_HUMAN	P17900	GM2A	Ganglioside GM2 activator	1.301537501	3.721082761	0.155241303	0.104452392	2.511310131	0.1298468475	2.511310131	0.1298468475	19.340555272241	0.003854	1	0.0517048236683914	0.003785	-1	GO:0016324,apical plasma membrane;GO:0035578,azurophil granule lumen;GO:0016323,basolateral plasma membrane;GO:0009898,cytoplasmic side of plasma membrane;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0043231,intracellular membrane-bounded organelle;GO:0043202,lysosomal lumen	GO:0032428,beta-N-acetylgalactosaminidase activity;GO:0005319,lipid transporter activity;GO:0016004,phospholipase activator activity;GO:0008047,enzyme activator activity	GO:0006689,ganglioside catabolic process;GO:0006687,glycosphingolipid metabolic process;GO:0007611,learning or memory;GO:0019915,lipid storage;GO:0006869,lipid transport;GO:0050885,neuromuscular process controlling balance;GO:0043312,neutrophil degranulation;GO:0009313,oligosaccharide catabolic process;GO:0051345,positive regulation of hydrolase activity	hsa:2760,path:hsa04142,Lysosome
MTMRE_HUMAN	Q8NCE2	MTMR14	Myotubularin-related protein 14	0.046460862	0.062218244	0.149004786	0.053404526	0.054339553	0.101204656	0.054339553	0.101204656	0.536927401838113	0.259122	0	1.86244918135414	0.259436	0	GO:0005829,cytosol;GO:0048471,perinuclear region of cytoplasm;GO:0001726,ruffle	GO:0004438,phosphatidylinositol-3-phosphatase activity;GO:0004725,protein tyrosine phosphatase activity	GO:0016236,macroautophagy;GO:0006661,phosphatidylinositol biosynthetic process	hsa:64419,path:hsa00562,Inositol phosphate metabolism;hsa:64419,path:hsa04070,Phosphatidylinositol signaling system;hsa:64419,path:hsa04140,Autophagy - animal
OAT_HUMAN	P04181	OAT	Ornithine aminotransferase, mitochondrial	0.594370622	0.619933531	0.702061007	0.293103362	0.6071520765	0.4975821845	0.6071520765	0.4975821845	1.22020461224934	0.368589	0	0.819534682922228	0.368259	0	GO:0005737,cytoplasm;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0042802,identical protein binding;GO:0050155,ornithine(lysine) transaminase activity;GO:0004587,ornithine-oxo-acid transaminase activity;GO:0030170,pyridoxal phosphate binding	GO:0019544,arginine catabolic process to glutamate;GO:0010121,arginine catabolic process to proline via ornithine;GO:0009064,glutamine family amino acid metabolic process;GO:0055129,L-proline biosynthetic process;GO:0007601,visual perception	hsa:4942,path:hsa00330,Arginine and proline metabolism
ARPC2_HUMAN	O15144	ARPC2	Actin-related protein 2/3 complex subunit 2	13.72486002	12.53455715	14.6179438	10.12395606	13.129708585	12.37094993	13.129708585	12.37094993	1.06133390396804	0.413706	0	0.942210548689036	0.413468	0	GO:0015629,actin cytoskeleton;GO:0005885,Arp2/3 protein complex;GO:0005829,cytosol;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0030027,lamellipodium;GO:0036195,muscle cell projection membrane;GO:0043005,neuron projection;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0035861,site of double-strand break;GO:0005737,cytoplasm;GO:0045202,synapse;GO:0042995,cell projection	GO:0003779,actin binding;GO:0005200,structural constituent of cytoskeleton	GO:0030041,actin filament polymerization;GO:0070358,actin polymerization-dependent cell motility;GO:0034314,Arp2/3 complex-mediated actin nucleation;GO:0048013,ephrin receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0061024,membrane organization;GO:0010592,positive regulation of lamellipodium assembly;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading	hsa:10109,path:hsa04144,Endocytosis;hsa:10109,path:hsa04810,Regulation of actin cytoskeleton;hsa:10109,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:10109,path:hsa05130,Pathogenic Escherichia coli infection;hsa:10109,path:hsa05132,Salmonella infection;hsa:10109,path:hsa05131,Shigellosis;hsa:10109,path:hsa05100,Bacterial invasion of epithelial cells
MPCP_HUMAN	Q00325	SLC25A3	Phosphate carrier protein, mitochondrial	16.78701543	19.8937518	16.30032381	15.80015925	18.340383615	16.05024153	18.340383615	16.05024153	1.14268583315207	0.389635	0	0.875131178656101	0.389347	0	GO:0070062,extracellular exosome;GO:0031305,integral component of mitochondrial inner membrane;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0016021,integral component of membrane	GO:0005315,inorganic phosphate transmembrane transporter activity;GO:0015317,phosphate;GO:0044877,protein-containing complex binding	GO:1990547,mitochondrial phosphate ion transmembrane transport;GO:0035435,phosphate ion transmembrane transport	
RU2B_HUMAN	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	8.297532486	0.016787231	0.051417606	36.07695969	4.1571598585	18.064188648	4.1571598585	18.064188648	0.23013266410724	0.026143	-1	4.3453197045249	0.026292	1	GO:0071013,catalytic step 2 spliceosome;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0001650,fibrillar center;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0005685,U1 snRNP;GO:0005686,U2 snRNP;GO:0071007,U2-type catalytic step 2 spliceosome;GO:0071005,U2-type precatalytic spliceosome	GO:0070990,snRNP binding;GO:0030619,U1 snRNA binding	GO:0000398,mRNA splicing, via spliceosome	hsa:6629,path:hsa03040,Spliceosome
CTL2_HUMAN	Q8IWA5	SLC44A2	Choline transporter-like protein 2	0.377704624	0.405127323	0.777056497	3.377282538	0.3914159735	2.0771695175	0.3914159735	2.0771695175	0.188437183485676	0.012344	-1	5.30680825037918	0.012434	1	GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005886,plasma membrane;GO:0035579,specific granule membrane	GO:0015220,choline transmembrane transporter activity;GO:0022857,transmembrane transporter activity	GO:0015871,choline transport;GO:0043312,neutrophil degranulation;GO:0006656,phosphatidylcholine biosynthetic process;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0055085,transmembrane transport	hsa:57153,path:hsa05231,Choline metabolism in cancer
ALG2_HUMAN	Q9H553	ALG2	Alpha-1,3/1,6-mannosyltransferase ALG2	0.323995946	0.244252325	0.940826477	1.014246361	0.2841241355	0.977536419	0.2841241355	0.977536419	0.290653248285781	0.056600	0	3.44052580144146	0.056834	0	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm	GO:0000033,alpha-1,3-mannosyltransferase activity;GO:0048306,calcium-dependent protein binding;GO:0004378,GDP-Man;GO:0102704,GDP-Man;GO:0046982,protein heterodimerization activity;GO:0047485,protein N-terminus binding	GO:0006488,dolichol-linked oligosaccharide biosynthetic process;GO:0006490,oligosaccharide-lipid intermediate biosynthetic process;GO:0033577,protein glycosylation in endoplasmic reticulum;GO:0051592,response to calcium ion;GO:0006486,protein glycosylation	hsa:85365,path:hsa00510,N-Glycan biosynthesis;hsa:85365,path:hsa00513,Various types of N-glycan biosynthesis
K1C23_HUMAN	Q9C075	KRT23	Keratin, type I cytoskeletal 23	0.01872003	2.55E-05	0.013116793	2.55E-05	0.009372765	0.0065711465	0.009372765	0.0065711465	1.42635155067689	0.320191	0	0.701089433054173	0.319773	0	GO:0005829,cytosol;GO:0005882,intermediate filament	GO:0005198,structural molecule activity	GO:0070268,cornification;GO:0031424,keratinization	hsa:25984,path:hsa04915,Estrogen signaling pathway;hsa:25984,path:hsa05150,Staphylococcus aureus infection
CO9_HUMAN	P02748	C9	Complement component C9	1.755972957	1.387657742	2.306119846	11.21825482	1.5718153495	6.762187333	1.5718153495	6.762187333	0.232441852332221	0.027083	-1	4.3021512260655	0.027235	1	GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005579,membrane attack complex;GO:0044218,other organism cell membrane;GO:0005886,plasma membrane		GO:0001906,cell killing;GO:0006956,complement activation;GO:0006957,complement activation, alternative pathway;GO:0006958,complement activation, classical pathway;GO:0019835,cytolysis;GO:0051260,protein homooligomerization;GO:0030449,regulation of complement activation	hsa:735,path:hsa04610,Complement and coagulation cascades;hsa:735,path:hsa05322,Systemic lupus erythematosus;hsa:735,path:hsa05020,Prion diseases;hsa:735,path:hsa05146,Amoebiasis
BAG6_HUMAN	P46379	BAG6	Large proline-rich protein BAG6	0.601323949	0.471608897	0.882079708	1.077720742	0.536466423	0.979900225	0.536466423	0.979900225	0.547470455984435	0.268836	0	1.82658258371559	0.269144	0	GO:0071818,BAT3 complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005576,extracellular region	GO:0042802,identical protein binding;GO:0051787,misfolded protein binding;GO:0031593,polyubiquitin modification-dependent protein binding;GO:0070628,proteasome binding;GO:0043022,ribosome binding;GO:0005102,signaling receptor binding;GO:0031625,ubiquitin protein ligase binding;GO:1990381,ubiquitin-specific protease binding	GO:0006915,apoptotic process;GO:0007420,brain development;GO:0030154,cell differentiation;GO:0006325,chromatin organization;GO:0061857,endoplasmic reticulum stress-induced pre-emptive quality control;GO:0071712,ER-associated misfolded protein catabolic process;GO:0002429,immune response-activating cell surface receptor signaling pathway;GO:0018393,internal peptidyl-lysine acetylation;GO:0042771,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0070059,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0001822,kidney development;GO:0030324,lung development;GO:1904378,maintenance of unfolded protein involved in ERAD pathway;GO:0030101,natural killer cell activation;GO:0032435,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0045861,negative regulation of proteolysis;GO:1904294,positive regulation of ERAD pathway;GO:0010498,proteasomal protein catabolic process;GO:1904379,protein localization to cytosolic proteasome complex involved in ERAD pathway;GO:0050821,protein stabilization;GO:0045995,regulation of embryonic development;GO:0007283,spermatogenesis;GO:0007130,synaptonemal complex assembly;GO:0071816,tail-anchored membrane protein insertion into ER membrane;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0002376,immune system process	
PARK7_HUMAN	Q99497	PARK7	Parkinson disease protein 7	10.45730428	57.59473175	4.106904231	2.08268921	34.026018015	3.0947967205	34.026018015	3.0947967205	10.9945890111654	0.014315	1	0.0909538318335014	0.014134	-1	GO:0005912,adherens junction;GO:0030424,axon;GO:0044297,cell body;GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0045121,membrane raft;GO:0005758,mitochondrial intermembrane space;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0016605,PML body;GO:0098793,presynapse	GO:0050681,androgen receptor binding;GO:0045296,cadherin binding;GO:0005507,copper ion binding;GO:1903135,cupric ion binding;GO:1903136,cuprous ion binding;GO:0019955,cytokine binding;GO:0019899,enzyme binding;GO:1990422,glyoxalase (glycolic acid-forming) activity;GO:0042802,identical protein binding;GO:0019900,kinase binding;GO:0036478,L-dopa decarboxylase activator activity;GO:0045340,mercury ion binding;GO:0003729,mRNA binding;GO:0016684,oxidoreductase activity, acting on peroxide as acceptor;GO:0019826,oxygen sensor activity;GO:0008233,peptidase activity;GO:0051920,peroxiredoxin activity;GO:0036524,protein deglycase activity;GO:0042803,protein homodimerization activity;GO:0044877,protein-containing complex binding;GO:0070491,repressing transcription factor binding;GO:0097110,scaffold protein binding;GO:0005102,signaling receptor binding;GO:0044388,small protein activating enzyme binding;GO:0016532,superoxide dismutase copper chaperone activity;GO:0003713,transcription coactivator activity;GO:0008134,transcription factor binding;GO:0036470,tyrosine 3-monooxygenase activator activity;GO:0044390,ubiquitin-like protein conjugating enzyme binding;GO:1990381,ubiquitin-specific protease binding	GO:0032148,activation of protein kinase B activity;GO:0008344,adult locomotory behavior;GO:0035973,aggrephagy;GO:0110095,cellular detoxification of aldehyde;GO:0140041,cellular detoxification of methylglyoxal;GO:0036471,cellular response to glyoxal;GO:0070301,cellular response to hydrogen peroxide;GO:0034599,cellular response to oxidative stress;GO:0070994,detection of oxidative stress;GO:0010273,detoxification of copper ion;GO:0050787,detoxification of mercury ion;GO:0006281,DNA repair;GO:0051583,dopamine uptake involved in synaptic transmission;GO:0042593,glucose homeostasis;GO:0036531,glutathione deglycation;GO:0046295,glycolate biosynthetic process;GO:1903189,glyoxal metabolic process;GO:0106044,guanine deglycation;GO:0106046,guanine deglycation, glyoxal removal;GO:0106045,guanine deglycation, methylglyoxal removal;GO:0016570,histone modification;GO:0042743,hydrogen peroxide metabolic process;GO:0006954,inflammatory response;GO:0030073,insulin secretion;GO:0019249,lactate biosynthetic process;GO:0051899,membrane depolarization;GO:0060081,membrane hyperpolarization;GO:0061727,methylglyoxal catabolic process to lactate;GO:0009438,methylglyoxal metabolic process;GO:0007005,mitochondrion organization;GO:0043066,negative regulation of apoptotic process;GO:0060548,negative regulation of cell death;GO:2001268,negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:1903073,negative regulation of death-inducing signaling complex assembly;GO:1902236,negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:2001237,negative regulation of extrinsic apoptotic signaling pathway;GO:0010629,negative regulation of gene expression;GO:1903206,negative regulation of hydrogen peroxide-induced cell death;GO:1903208,negative regulation of hydrogen peroxide-induced neuron death;GO:1903384,negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway;GO:0043524,negative regulation of neuron apoptotic process;GO:1901215,negative regulation of neuron death;GO:1905259,negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway;GO:1903202,negative regulation of oxidative stress-induced cell death;GO:1903377,negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:0032435,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1901984,negative regulation of protein acetylation;GO:0032091,negative regulation of protein binding;GO:0046826,negative regulation of protein export from nucleus;GO:1903094,negative regulation of protein K48-linked deubiquitination;GO:0006469,negative regulation of protein kinase activity;GO:0001933,negative regulation of protein phosphorylation;GO:0033234,negative regulation of protein sumoylation;GO:0031397,negative regulation of protein ubiquitination;GO:1903427,negative regulation of reactive oxygen species biosynthetic process;GO:1903122,negative regulation of TRAIL-activated apoptotic signaling pathway;GO:0051444,negative regulation of ubiquitin-protein transferase activity;GO:2000157,negative regulation of ubiquitin-specific protease activity;GO:0036527,peptidyl-arginine deglycation;GO:0036526,peptidyl-cysteine deglycation;GO:0036528,peptidyl-lysine deglycation;GO:0002866,positive regulation of acute inflammatory response to antigenic stimulus;GO:2000825,positive regulation of androgen receptor activity;GO:1903599,positive regulation of autophagy of mitochondrion;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:1903181,positive regulation of dopamine biosynthetic process;GO:0010628,positive regulation of gene expression;GO:0032757,positive regulation of interleukin-8 production;GO:1903197,positive regulation of L-dopa biosynthetic process;GO:1903200,positive regulation of L-dopa decarboxylase activity;GO:1902958,positive regulation of mitochondrial electron transport, NADH to ubiquinone;GO:0033864,positive regulation of NAD(P)H oxidase activity;GO:2000277,positive regulation of oxidative phosphorylation uncoupler activity;GO:1902177,positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0051897,positive regulation of protein kinase B signaling;GO:1900182,positive regulation of protein localization to nucleus;GO:0031334,positive regulation of protein-containing complex assembly;GO:1903168,positive regulation of pyrroline-5-carboxylate reductase activity;GO:1903428,positive regulation of reactive oxygen species biosynthetic process;GO:1901671,positive regulation of superoxide dismutase activity;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:2000679,positive regulation of transcription regulatory region DNA binding;GO:1903178,positive regulation of tyrosine 3-monooxygenase activity;GO:0036529,protein deglycation, glyoxal removal;GO:0036530,protein deglycation, methylglyoxal removal;GO:0006517,protein deglycosylation;GO:0050821,protein stabilization;GO:0007265,Ras protein signal transduction;GO:0060765,regulation of androgen receptor signaling pathway;GO:0035065,regulation of histone acetylation;GO:0033182,regulation of histone ubiquitination;GO:0050727,regulation of inflammatory response;GO:0051881,regulation of mitochondrial membrane potential;GO:0043523,regulation of neuron apoptotic process;GO:1902903,regulation of supramolecular fiber organization;GO:0007338,single fertilization;GO:0006914,autophagy	hsa:11315,path:hsa05012,Parkinson disease
ADDG_HUMAN	Q9UEY8	ADD3	Gamma-adducin	0.354421801	0.806050627	0.557783868	13.86310658	0.580236214	7.210445224	0.580236214	7.210445224	0.0804716208187368	0.000195	-1	12.426741127192	0.000198	1	GO:0005903,brush border;GO:0005938,cell cortex;GO:0005911,cell-cell junction;GO:0000794,condensed nuclear chromosome;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0014069,postsynaptic density	GO:0051015,actin filament binding;GO:0005516,calmodulin binding;GO:0005200,structural constituent of cytoskeleton	GO:0051016,barbed-end actin filament capping;GO:0055085,transmembrane transport	
GPX8_HUMAN	Q8TED1	GPX8	Probable glutathione peroxidase 8	0.441433617	2.689663274	0.070538571	0.002143274	1.5655484455	0.0363409225	1.5655484455	0.0363409225	43.0794910475924	0.000420	1	0.0232129019095245	0.000408	-1	GO:0005788,endoplasmic reticulum lumen;GO:0016021,integral component of membrane	GO:0004602,glutathione peroxidase activity;GO:0004601,peroxidase activity	GO:0034599,cellular response to oxidative stress;GO:0006979,response to oxidative stress	hsa:493869,path:hsa00590,Arachidonic acid metabolism;hsa:493869,path:hsa00480,Glutathione metabolism;hsa:493869,path:hsa04918,Thyroid hormone synthesis;hsa:493869,path:hsa05014,Amyotrophic lateral sclerosis (ALS);hsa:493869,path:hsa05016,Huntington disease
NTPCR_HUMAN	Q9BSD7	NTPCR	Cancer-related nucleoside-triphosphatase	3.291644867	6.101475393	1.694910494	2.622034552	4.69656013	2.158472523	4.69656013	2.158472523	2.17587209471279	0.205221	0	0.459585837986492	0.204663	0	GO:0016020,membrane	GO:0005524,ATP binding;GO:0017111,nucleoside-triphosphatase activity;GO:0003723,RNA binding		hsa:84284,path:hsa00230,Purine metabolism;hsa:84284,path:hsa00730,Thiamine metabolism
CBPM_HUMAN	P14384	CPM	Carboxypeptidase M	0.207515422	0.338628883	0.69739975	0.85939462	0.2730721525	0.778397185	0.2730721525	0.778397185	0.35081338648469	0.097406	0	2.85051836254156	0.097701	0	GO:0031225,anchored component of membrane;GO:0009986,cell surface;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0004180,carboxypeptidase activity;GO:0004181,metallocarboxypeptidase activity;GO:0008270,zinc ion binding	GO:0009653,anatomical structure morphogenesis;GO:0006518,peptide metabolic process;GO:0016485,protein processing	
TRI25_HUMAN	Q14258	TRIM25	E3 ubiquitin/ISG15 ligase TRIM25	2.165943156	2.759319021	2.977783387	2.319030049	2.4626310885	2.648406718	2.4626310885	2.648406718	0.929853814281104	0.457573	0	1.07543786414763	0.457429	0	GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0016604,nuclear body;GO:0005654,nucleoplasm	GO:0045296,cadherin binding;GO:0016874,ligase activity;GO:0046872,metal ion binding;GO:0039552,RIG-I binding;GO:0003723,RNA binding;GO:0003713,transcription coactivator activity;GO:0061630,ubiquitin protein ligase activity	GO:1990830,cellular response to leukemia inhibitory factor;GO:0051607,defense response to virus;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0032480,negative regulation of type I interferon production;GO:0046597,negative regulation of viral entry into host cell;GO:1902187,negative regulation of viral release from host cell;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0006513,protein monoubiquitination;GO:0032880,regulation of protein localization;GO:0046596,regulation of viral entry into host cell;GO:1902186,regulation of viral release from host cell;GO:0043627,response to estrogen;GO:0033280,response to vitamin D;GO:0019985,translesion synthesis;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0016032,viral process	hsa:7706,path:hsa04064,NF-kappa B signaling pathway;hsa:7706,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:7706,path:hsa05164,Influenza A
CATA_HUMAN	P04040	CAT	Catalase	5.708232783	16.03891764	30.14355792	106.7416767	10.8735752115	68.44261731	10.8735752115	68.44261731	0.158871411393429	0.006087	-1	6.29439866637556	0.006141	1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0005764,lysosome;GO:0016020,membrane;GO:0005758,mitochondrial intermembrane space;GO:0005739,mitochondrion;GO:0005782,peroxisomal matrix;GO:0005778,peroxisomal membrane;GO:0005777,peroxisome;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0034774,secretory granule lumen	GO:0004046,aminoacylase activity;GO:0016209,antioxidant activity;GO:0004096,catalase activity;GO:0019899,enzyme binding;GO:0020037,heme binding;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0050661,NADP binding;GO:0016684,oxidoreductase activity, acting on peroxide as acceptor;GO:0000268,peroxisome targeting sequence binding;GO:0042803,protein homodimerization activity	GO:0009060,aerobic respiration;GO:0007568,aging;GO:0071363,cellular response to growth factor stimulus;GO:0034599,cellular response to oxidative stress;GO:0008203,cholesterol metabolic process;GO:0020027,hemoglobin metabolic process;GO:0042744,hydrogen peroxide catabolic process;GO:0043066,negative regulation of apoptotic process;GO:0032088,negative regulation of NF-kappaB transcription factor activity;GO:0043312,neutrophil degranulation;GO:0001649,osteoblast differentiation;GO:0051781,positive regulation of cell division;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0014068,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0008104,protein localization;GO:0014823,response to activity;GO:0046686,response to cadmium ion;GO:0042493,response to drug;GO:0032355,response to estradiol;GO:0045471,response to ethanol;GO:0070542,response to fatty acid;GO:0042542,response to hydrogen peroxide;GO:0055093,response to hyperoxia;GO:0001666,response to hypoxia;GO:0014854,response to inactivity;GO:0032868,response to insulin;GO:0033591,response to L-ascorbic acid;GO:0010288,response to lead ion;GO:0009642,response to light intensity;GO:0010193,response to ozone;GO:0080184,response to phenylpropanoid;GO:0000302,response to reactive oxygen species;GO:0033189,response to vitamin A;GO:0033197,response to vitamin E;GO:0006641,triglyceride metabolic process;GO:0001657,ureteric bud development;GO:0009650,UV protection	hsa:847,path:hsa00630,Glyoxylate and dicarboxylate metabolism;hsa:847,path:hsa00380,Tryptophan metabolism;hsa:847,path:hsa04068,FoxO signaling pathway;hsa:847,path:hsa04146,Peroxisome;hsa:847,path:hsa04211,Longevity regulating pathway;hsa:847,path:hsa04213,Longevity regulating pathway - multiple species;hsa:847,path:hsa05014,Amyotrophic lateral sclerosis (ALS)
MRPP3_HUMAN	O15091	PRORP	Mitochondrial ribonuclease P catalytic subunit	0.010565612	0.008636316	0.03324916	2.55E-05	0.009600964	0.01663733	0.009600964	0.01663733	0.57707360495945	0.296027	0	1.73288119817968	0.296319	0	GO:0005759,mitochondrial matrix;GO:0030678,mitochondrial ribonuclease P complex;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0046872,metal ion binding;GO:0004526,ribonuclease P activity;GO:0016787,hydrolase activity	GO:0097745,mitochondrial tRNA 5'-end processing;GO:0070901,mitochondrial tRNA methylation;GO:0001682,tRNA 5'-leader removal;GO:0008033,tRNA processing	
CKAP4_HUMAN	Q07065	CKAP4	Cytoskeleton-associated protein 4	15.83771591	15.24476947	16.34533375	13.15540622	15.54124269	14.750369985	15.54124269	14.750369985	1.05361714355669	0.416104	0	0.949111359961653	0.415870	0	GO:0035577,azurophil granule membrane;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0042599,lamellar body;GO:0005811,lipid droplet;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0005791,rough endoplasmic reticulum;GO:0035579,specific granule membrane	GO:0003723,RNA binding	GO:0044267,cellular protein metabolic process;GO:0043312,neutrophil degranulation;GO:0043687,post-translational protein modification	hsa:10970,path:hsa04141,Protein processing in endoplasmic reticulum
ROA1_HUMAN	P09651	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	15.74866312	11.05536759	10.65601973	3.106978383	13.402015355	6.8814990565	13.402015355	6.8814990565	1.94754300552304	0.232795	0	0.513467480391497	0.232258	0	GO:0071013,catalytic step 2 spliceosome;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0005681,spliceosomal complex	GO:0098505,G-rich strand telomeric DNA binding;GO:0042802,identical protein binding;GO:0035198,miRNA binding;GO:0036002,pre-mRNA binding;GO:0019904,protein domain specific binding;GO:0003723,RNA binding;GO:0003697,single-stranded DNA binding;GO:0003727,single-stranded RNA binding;GO:0061752,telomeric repeat-containing RNA binding	GO:0042149,cellular response to glucose starvation;GO:1903936,cellular response to sodium arsenite;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0051170,import into nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0051028,mRNA transport;GO:0032211,negative regulation of telomere maintenance via telomerase;GO:0051168,nuclear export;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0006405,RNA export from nucleus;GO:0016070,RNA metabolic process;GO:0016032,viral process;GO:0006397,mRNA processing;GO:0008380,RNA splicing	hsa:3178,path:hsa03040,Spliceosome
LONM_HUMAN	P36776	LONP1	Lon protease homolog, mitochondrial	1.935901312	1.277450009	2.988153774	2.333044946	1.6066756605	2.66059936	1.6066756605	2.66059936	0.603877338563293	0.320437	0	1.65596543559515	0.320710	0	GO:0005829,cytosol;GO:0016020,membrane;GO:0005759,mitochondrial matrix;GO:0042645,mitochondrial nucleoid;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0004176,ATP-dependent peptidase activity;GO:0016887,ATPase activity;GO:0070182,DNA polymerase binding;GO:0051880,G-quadruplex DNA binding;GO:0042802,identical protein binding;GO:0001018,mitochondrial promoter sequence-specific DNA binding;GO:0043565,sequence-specific DNA binding;GO:0004252,serine-type endopeptidase activity;GO:0003697,single-stranded DNA binding;GO:0003727,single-stranded RNA binding	GO:0007568,aging;GO:0034599,cellular response to oxidative stress;GO:0051131,chaperone-mediated protein complex assembly;GO:0032042,mitochondrial DNA metabolic process;GO:0000002,mitochondrial genome maintenance;GO:0007005,mitochondrion organization;GO:0070407,oxidation-dependent protein catabolic process;GO:0006515,protein quality control for misfolded or incompletely synthesized proteins;GO:0051603,proteolysis involved in cellular protein catabolic process;GO:0010044,response to aluminum ion;GO:0009725,response to hormone;GO:0001666,response to hypoxia;GO:0030163,protein catabolic process	
SCAF4_HUMAN	O95104	SCAF4	SR-related and CTD-associated factor 4	0.16277204	0.231571468	0.191370365	0.058595196	0.197171754	0.1249827805	0.197171754	0.1249827805	1.57759135467465	0.290437	0	0.633877713031857	0.289972	0	GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0008022,protein C-terminus binding;GO:0003723,RNA binding;GO:1990269,RNA polymerase II C-terminal domain phosphoserine binding	GO:0006397,mRNA processing;GO:2000805,negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled	
DD19A_HUMAN	Q9NUU7	DDX19A	ATP-dependent RNA helicase DDX19A	2.332724416	2.224207944	2.280835739	3.281341362	2.27846618	2.7810885505	2.27846618	2.7810885505	0.819271353150681	0.499879	0	1.22059680978017	0.499969	0	GO:0010494,cytoplasmic stress granule;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0003676,nucleic acid binding;GO:0016787,hydrolase activity	GO:0016973,poly(A)+ mRNA export from nucleus	
SAP_HUMAN	P07602	PSAP	Prosaposin	2.021551428	6.111423763	3.124816118	0.853395578	4.0664875955	1.989105848	4.0664875955	1.989105848	2.04437968929042	0.220479	0	0.489145927852124	0.219932	0	GO:0035577,azurophil granule membrane;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043231,intracellular membrane-bounded organelle;GO:0005770,late endosome;GO:0043202,lysosomal lumen;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0005886,plasma membrane	GO:0008047,enzyme activator activity;GO:1905573,ganglioside GM1 binding;GO:1905574,ganglioside GM2 binding;GO:1905575,ganglioside GM3 binding;GO:1905577,ganglioside GP1c binding;GO:1905576,ganglioside GT1b binding;GO:0042802,identical protein binding;GO:0005543,phospholipid binding;GO:0002020,protease binding;GO:0042803,protein homodimerization activity	GO:0007193,adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0060742,epithelial cell differentiation involved in prostate gland development;GO:0007186,G protein-coupled receptor signaling pathway;GO:1905572,ganglioside GM1 transport to membrane;GO:0006687,glycosphingolipid metabolic process;GO:0007041,lysosomal transport;GO:0043312,neutrophil degranulation;GO:0002576,platelet degranulation;GO:1903771,positive regulation of beta-galactosidase activity;GO:0060736,prostate gland growth;GO:0010506,regulation of autophagy;GO:0019216,regulation of lipid metabolic process;GO:0006665,sphingolipid metabolic process	hsa:5660,path:hsa04142,Lysosome
MYG_HUMAN	P02144	MB	Myoglobin	0.14388483	0.258671225	0.792301322	2.55E-05	0.2012780275	0.396163411	0.2012780275	0.396163411	0.508068190830475	0.232547	0	1.96823973247651	0.232873	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0020037,heme binding;GO:0046872,metal ion binding;GO:0019825,oxygen binding;GO:0005344,oxygen carrier activity	GO:0015671,oxygen transport;GO:0009725,response to hormone;GO:0042542,response to hydrogen peroxide;GO:0031444,slow-twitch skeletal muscle fiber contraction	
FA83H_HUMAN	Q6ZRV2	FAM83H	Protein FAM83H	0.023950866	0.073544873	0.030558757	0.194129917	0.0487478695	0.112344337	0.0487478695	0.112344337	0.43391479091643	0.165628	0	2.30459993743932	0.165962	0	GO:0005737,cytoplasm;GO:0005856,cytoskeleton	GO:1990254,keratin filament binding;GO:0019901,protein kinase binding	GO:0031214,biomineral tissue development;GO:0045104,intermediate filament cytoskeleton organization;GO:0030335,positive regulation of cell migration;GO:0044380,protein localization to cytoskeleton;GO:0007165,signal transduction	
MRCKB_HUMAN	Q9Y5S2	CDC42BPB	Serine/threonine-protein kinase MRCK beta	0.435963987	0.423488785	0.246446318	1.027331684	0.429726386	0.636889001	0.429726386	0.636889001	0.67472728422892	0.383256	0	1.48208027654136	0.383473	0	GO:0042641,actomyosin;GO:0031252,cell leading edge;GO:0005911,cell-cell junction;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0070062,extracellular exosome;GO:0030027,lamellipodium;GO:0005886,plasma membrane;GO:0016020,membrane	GO:0005524,ATP binding;GO:0000287,magnesium ion binding;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0044877,protein-containing complex binding;GO:0031267,small GTPase binding	GO:0031532,actin cytoskeleton reorganization;GO:0031032,actomyosin structure organization;GO:0016477,cell migration;GO:0007010,cytoskeleton organization;GO:0007163,establishment or maintenance of cell polarity;GO:0035556,intracellular signal transduction;GO:0018107,peptidyl-threonine phosphorylation;GO:0006468,protein phosphorylation;GO:0007165,signal transduction;GO:0030036,actin cytoskeleton organization	
IF4G2_HUMAN	P78344	EIF4G2	Eukaryotic translation initiation factor 4 gamma 2	1.490032591	1.33207639	2.404066815	1.377873709	1.4110544905	1.890970262	1.4110544905	1.890970262	0.746206600312998	0.443122	0	1.34011143774465	0.443276	0	GO:0005912,adherens junction;GO:0030424,axon;GO:0005829,cytosol;GO:0016281,eukaryotic translation initiation factor 4F complex;GO:0016020,membrane;GO:0005737,cytoplasm	GO:0045296,cadherin binding;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0008135,translation factor activity, RNA binding;GO:0003743,translation initiation factor activity	GO:0007050,cell cycle arrest;GO:0008219,cell death;GO:0034645,cellular macromolecule biosynthetic process;GO:0007507,heart development;GO:0010507,negative regulation of autophagy;GO:0045773,positive regulation of axon extension;GO:0030307,positive regulation of cell growth;GO:0060999,positive regulation of dendritic spine development;GO:0045727,positive regulation of translation;GO:0006446,regulation of translational initiation;GO:0045892,negative regulation of transcription, DNA-templated	hsa:1982,path:hsa03013,RNA transport;hsa:1982,path:hsa05416,Viral myocarditis
MROH1_HUMAN	Q8NDA8	MROH1	Maestro heat-like repeat-containing protein family member 1	0.055347077	0.097726772	0.179516307	0.033581316	0.0765369245	0.1065488115	0.0765369245	0.1065488115	0.718327341455141	0.420252	0	1.3921229811109	0.420431	0				
NDUAC_HUMAN	Q9UI09	NDUFA12	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	0.339998766	2.614097668	0.127280976	0.007744873	1.477048217	0.0675129245	1.477048217	0.0675129245	21.878006736325	0.002816	1	0.0457080031125348	0.002762	-1	GO:0005829,cytosol;GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion;GO:0016020,membrane;GO:0070469,respirasome	GO:0008137,NADH dehydrogenase (ubiquinone) activity	GO:0042775,mitochondrial ATP synthesis coupled electron transport;GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0007585,respiratory gaseous exchange by respiratory system;GO:0006979,response to oxidative stress	hsa:55967,path:hsa00190,Oxidative phosphorylation;hsa:55967,path:hsa04723,Retrograde endocannabinoid signaling;hsa:55967,path:hsa04714,Thermogenesis;hsa:55967,path:hsa05010,Alzheimer disease;hsa:55967,path:hsa05012,Parkinson disease;hsa:55967,path:hsa05016,Huntington disease;hsa:55967,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
PDLI7_HUMAN	Q9NR12	PDLIM7	PDZ and LIM domain protein 7	2.194418373	2.804825632	0.640946279	1.872617275	2.4996220025	1.256781777	2.4996220025	1.256781777	1.98890694330938	0.227414	0	0.502788731953483	0.226873	0	GO:0015629,actin cytoskeleton;GO:0005912,adherens junction;GO:0005829,cytosol;GO:0031941,filamentous actin;GO:0005925,focal adhesion;GO:0005654,nucleoplasm;GO:0001726,ruffle;GO:0001725,stress fiber;GO:0030018,Z disc	GO:0003779,actin binding;GO:0046872,metal ion binding;GO:0051371,muscle alpha-actinin binding	GO:0030036,actin cytoskeleton organization;GO:0007411,axon guidance;GO:0007507,heart development;GO:0061061,muscle structure development;GO:0001503,ossification;GO:0045669,positive regulation of osteoblast differentiation;GO:0006898,receptor-mediated endocytosis	
F1142_HUMAN	Q9NRY5	FAM114A2	Protein FAM114A2	0.141081758	0.114834069	0.243123029	0.021880781	0.1279579135	0.132501905	0.1279579135	0.132501905	0.965706217582306	0.444948	0	1.03551160983881	0.444776	0		GO:0017076,purine nucleotide binding		
U5S1_HUMAN	Q15029	EFTUD2	116 kDa U5 small nuclear ribonucleoprotein component	3.662299224	1.884304703	4.618146285	3.849093863	2.7733019635	4.233620074	2.7733019635	4.233620074	0.655066329766274	0.366125	0	1.52656296707663	0.366359	0	GO:0015030,Cajal body;GO:0071013,catalytic step 2 spliceosome;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0071007,U2-type catalytic step 2 spliceosome;GO:0071005,U2-type precatalytic spliceosome;GO:0046540,U4/U6 x U5 tri-snRNP complex	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0003723,RNA binding;GO:0030623,U5 snRNA binding	GO:0035690,cellular response to drug;GO:0000398,mRNA splicing, via spliceosome;GO:0042220,response to cocaine	hsa:9343,path:hsa03040,Spliceosome
RAB6A_HUMAN	P20340	RAB6A	Ras-related protein Rab-6A	5.707355207	13.07777073	0.819654943	0.226018174	9.3925629685	0.5228365585	9.3925629685	0.5228365585	17.9646254949098	0.004629	1	0.0556649511164786	0.004549	-1	GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0012505,endomembrane system;GO:0005789,endoplasmic reticulum membrane;GO:0070381,endosome to plasma membrane transport vesicle;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0005802,trans-Golgi network;GO:0032588,trans-Golgi network membrane	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0031489,myosin V binding;GO:0019904,protein domain specific binding	GO:0019882,antigen processing and presentation;GO:0034498,early endosome to Golgi transport;GO:0006891,intra-Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0072385,minus-end-directed organelle transport along microtubule;GO:0043312,neutrophil degranulation;GO:0018125,peptidyl-cysteine methylation;GO:0034067,protein localization to Golgi apparatus;GO:0042147,retrograde transport, endosome to Golgi;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0016032,viral process	
MINK1_HUMAN	Q8N4C8	MINK1	Misshapen-like kinase 1	0.167228663	0.116774858	0.23608237	0.082258801	0.1420017605	0.1591705855	0.1420017605	0.1591705855	0.892135692370121	0.471442	0	1.12090571933437	0.471328	0	GO:0030424,axon;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0014069,postsynaptic density	GO:0005524,ATP binding;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity	GO:0031532,actin cytoskeleton reorganization;GO:0032147,activation of protein kinase activity;GO:0007268,chemical synaptic transmission;GO:0048813,dendrite morphogenesis;GO:0007254,JNK cascade;GO:0000165,MAPK cascade;GO:0007275,multicellular organism development;GO:0048812,neuron projection morphogenesis;GO:0046330,positive regulation of JNK cascade;GO:1900745,positive regulation of p38MAPK cascade;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:2000311,regulation of AMPA receptor activity;GO:0030334,regulation of cell migration;GO:0022407,regulation of cell-cell adhesion;GO:0001952,regulation of cell-matrix adhesion;GO:0031098,stress-activated protein kinase signaling cascade	
TM109_HUMAN	Q9BVC6	TMEM109	Transmembrane protein 109	7.60705631	12.78893314	1.245665361	0.946298261	10.197994725	1.095981811	10.197994725	1.095981811	9.30489413478049	0.020285	1	0.107470325348693	0.020056	-1	GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005640,nuclear outer membrane;GO:0033017,sarcoplasmic reticulum membrane	GO:0005244,voltage-gated ion channel activity	GO:0071480,cellular response to gamma radiation;GO:0042771,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0060548,negative regulation of cell death;GO:0034765,regulation of ion transmembrane transport	
NDUV2_HUMAN	P19404	NDUFV2	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	0.080773743	1.422537685	0.685178454	0.288578677	0.751655714	0.4868785655	0.751655714	0.4868785655	1.54382584747408	0.296715	0	0.647741454540449	0.296259	0	GO:0005829,cytosol;GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0051537,2 iron, 2 sulfur cluster binding;GO:0009055,electron transfer activity;GO:0046872,metal ion binding;GO:0008137,NADH dehydrogenase (ubiquinone) activity;GO:0016491,oxidoreductase activity	GO:0048738,cardiac muscle tissue development;GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0007399,nervous system development	hsa:4729,path:hsa00190,Oxidative phosphorylation;hsa:4729,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4729,path:hsa04714,Thermogenesis;hsa:4729,path:hsa05010,Alzheimer disease;hsa:4729,path:hsa05012,Parkinson disease;hsa:4729,path:hsa05016,Huntington disease;hsa:4729,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
KCC2G_HUMAN	Q13555	CAMK2G	Calcium/calmodulin-dependent protein kinase type II subunit gamma	0.028471583	0.043319064	0.076496911	0.086050762	0.0358953235	0.0812738365	0.0358953235	0.0812738365	0.44165902639529	0.172443	0	2.26419011100429	0.172779	0	GO:0005954,calcium- and calmodulin-dependent protein kinase complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030666,endocytic vesicle membrane;GO:0016020,membrane;GO:0043005,neuron projection;GO:0005654,nucleoplasm;GO:0033017,sarcoplasmic reticulum membrane	GO:0005524,ATP binding;GO:0004723,calcium-dependent protein serine/threonine phosphatase activity;GO:0005516,calmodulin binding;GO:0004683,calmodulin-dependent protein kinase activity;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:0106310,protein serine kinase activity;GO:0106311,protein threonine kinase activity	GO:0030154,cell differentiation;GO:0030073,insulin secretion;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0007399,nervous system development;GO:0051924,regulation of calcium ion transport;GO:1900034,regulation of cellular response to heat;GO:0010975,regulation of neuron projection development;GO:0014733,regulation of skeletal muscle adaptation	hsa:818,path:hsa04012,ErbB signaling pathway;hsa:818,path:hsa04310,Wnt signaling pathway;hsa:818,path:hsa04066,HIF-1 signaling pathway;hsa:818,path:hsa04020,Calcium signaling pathway;hsa:818,path:hsa04024,cAMP signaling pathway;hsa:818,path:hsa04114,Oocyte meiosis;hsa:818,path:hsa04217,Necroptosis;hsa:818,path:hsa04911,Insulin secretion;hsa:818,path:hsa04922,Glucagon signaling pathway;hsa:818,path:hsa04912,GnRH signaling pathway;hsa:818,path:hsa04921,Oxytocin signaling pathway;hsa:818,path:hsa04916,Melanogenesis;hsa:818,path:hsa04925,Aldosterone synthesis and secretion;hsa:818,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:818,path:hsa04971,Gastric acid secretion;hsa:818,path:hsa04725,Cholinergic synapse;hsa:818,path:hsa04728,Dopaminergic synapse;hsa:818,path:hsa04720,Long-term potentiation;hsa:818,path:hsa04722,Neurotrophin signaling pathway;hsa:818,path:hsa04740,Olfactory transduction;hsa:818,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:818,path:hsa04360,Axon guidance;hsa:818,path:hsa04713,Circadian entrainment;hsa:818,path:hsa05200,Pathways in cancer;hsa:818,path:hsa05205,Proteoglycans in cancer;hsa:818,path:hsa05214,Glioma;hsa:818,path:hsa05031,Amphetamine addiction;hsa:818,path:hsa04934,Cushing syndrome;hsa:818,path:hsa05152,Tuberculosis
CTBP1_HUMAN	Q13363	CTBP1	C-terminal-binding protein 1	2.513441185	0.630153391	2.225278027	2.072747587	1.571797288	2.149012807	1.571797288	2.149012807	0.731404337321848	0.431059	0	1.36723279993342	0.431227	0	GO:0005737,cytoplasm;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0017053,transcription repressor complex	GO:0042802,identical protein binding;GO:0051287,NAD binding;GO:0016616,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0008022,protein C-terminus binding;GO:0019904,protein domain specific binding;GO:0070491,repressing transcription factor binding;GO:0001226,RNA polymerase II transcription corepressor binding;GO:0003714,transcription corepressor activity;GO:0008134,transcription factor binding;GO:0016491,oxidoreductase activity	GO:0006342,chromatin silencing;GO:0008285,negative regulation of cell population proliferation;GO:0035067,negative regulation of histone acetylation;GO:0090241,negative regulation of histone H4 acetylation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0031065,positive regulation of histone deacetylation;GO:0006468,protein phosphorylation;GO:0051726,regulation of cell cycle;GO:0019079,viral genome replication;GO:0050872,white fat cell differentiation	hsa:1487,path:hsa04310,Wnt signaling pathway;hsa:1487,path:hsa04330,Notch signaling pathway;hsa:1487,path:hsa05200,Pathways in cancer;hsa:1487,path:hsa05220,Chronic myeloid leukemia
GNA11_HUMAN	P29992	GNA11	Guanine nucleotide-binding protein subunit alpha-11	0.747692331	0.63574748	0.854693221	2.8346869	0.6917199055	1.8446900605	0.6917199055	1.8446900605	0.374978930234226	0.116107	0	2.66681650453097	0.116420	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005834,heterotrimeric G-protein complex;GO:0005765,lysosomal membrane;GO:0001750,photoreceptor outer segment;GO:0005886,plasma membrane;GO:0045202,synapse	GO:0001664,G protein-coupled receptor binding;GO:0031683,G-protein beta/gamma-subunit complex binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0046872,metal ion binding;GO:0031826,type 2A serotonin receptor binding;GO:0019001,guanyl nucleotide binding	GO:0001508,action potential;GO:0007188,adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0071467,cellular response to pH;GO:0048066,developmental pigmentation;GO:0009649,entrainment of circadian clock;GO:0007213,G protein-coupled acetylcholine receptor signaling pathway;GO:0007186,G protein-coupled receptor signaling pathway;GO:0007507,heart development;GO:0060158,phospholipase C-activating dopamine receptor signaling pathway;GO:0007603,phototransduction, visible light;GO:0030168,platelet activation;GO:0045634,regulation of melanocyte differentiation;GO:0007165,signal transduction;GO:0001501,skeletal system development	hsa:2767,path:hsa04020,Calcium signaling pathway;hsa:2767,path:hsa04022,cGMP-PKG signaling pathway;hsa:2767,path:hsa04540,Gap junction;hsa:2767,path:hsa04911,Insulin secretion;hsa:2767,path:hsa04929,GnRH secretion;hsa:2767,path:hsa04912,GnRH signaling pathway;hsa:2767,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:2767,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:2767,path:hsa04925,Aldosterone synthesis and secretion;hsa:2767,path:hsa04927,Cortisol synthesis and secretion;hsa:2767,path:hsa04270,Vascular smooth muscle contraction;hsa:2767,path:hsa04725,Cholinergic synapse;hsa:2767,path:hsa04730,Long-term depression;hsa:2767,path:hsa05200,Pathways in cancer;hsa:2767,path:hsa04934,Cushing syndrome;hsa:2767,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:2767,path:hsa05163,Human cytomegalovirus infection;hsa:2767,path:hsa05146,Amoebiasis;hsa:2767,path:hsa05142,Chagas disease (American trypanosomiasis)
PMGE_HUMAN	P07738	BPGM	Bisphosphoglycerate mutase	0.419428049	0.711114441	0.638816612	5.359692551	0.565271245	2.9992545815	0.565271245	2.9992545815	0.188470578151887	0.012353	-1	5.30586794928866	0.012443	1	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0004082,bisphosphoglycerate mutase activity;GO:0016787,hydrolase activity;GO:0004619,phosphoglycerate mutase activity	GO:1901136,carbohydrate derivative catabolic process;GO:0005975,carbohydrate metabolic process;GO:0048821,erythrocyte development;GO:0006096,glycolytic process;GO:0007585,respiratory gaseous exchange by respiratory system	hsa:669,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:669,path:hsa00260,Glycine, serine and threonine metabolism
TAOK3_HUMAN	Q9H2K8	TAOK3	Serine/threonine-protein kinase TAO3	0.259838496	0.136876774	0.322484047	0.266260398	0.198357635	0.2943722225	0.198357635	0.2943722225	0.673832718710408	0.382482	0	1.48404785376676	0.382700	0	GO:0005737,cytoplasm;GO:0005886,plasma membrane	GO:0005524,ATP binding;GO:0004860,protein kinase inhibitor activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0016740,transferase activity;GO:0016301,kinase activity;GO:0004672,protein kinase activity	GO:0032147,activation of protein kinase activity;GO:0006974,cellular response to DNA damage stimulus;GO:0006281,DNA repair;GO:0000165,MAPK cascade;GO:0007095,mitotic G2 DNA damage checkpoint;GO:0046329,negative regulation of JNK cascade;GO:0048812,neuron projection morphogenesis;GO:0046330,positive regulation of JNK cascade;GO:0043507,positive regulation of JUN kinase activity;GO:0032874,positive regulation of stress-activated MAPK cascade;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:0031098,stress-activated protein kinase signaling cascade	hsa:51347,path:hsa04010,MAPK signaling pathway
MBB1A_HUMAN	Q9BQG0	MYBBP1A	Myb-binding protein 1A	0.185295284	0.110999567	0.718136418	0.222895756	0.1481474255	0.470516087	0.1481474255	0.470516087	0.314861552225737	0.071910	0	3.17599907937651	0.072172	0	GO:0005737,cytoplasm;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0042564,NLS-dependent protein nuclear import complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0070888,E-box binding;GO:0003723,RNA binding;GO:0043565,sequence-specific DNA binding;GO:0003714,transcription corepressor activity;GO:0008134,transcription factor binding;GO:0003677,DNA binding	GO:0042149,cellular response to glucose starvation;GO:0032922,circadian regulation of gene expression;GO:0072332,intrinsic apoptotic signaling pathway by p53 class mediator;GO:0045892,negative regulation of transcription, DNA-templated;GO:0001649,osteoblast differentiation;GO:2000210,positive regulation of anoikis;GO:0071158,positive regulation of cell cycle arrest;GO:0045815,positive regulation of gene expression, epigenetic;GO:0006355,regulation of transcription, DNA-templated;GO:0022904,respiratory electron transport chain;GO:0042254,ribosome biogenesis	
IF4A2_HUMAN	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	2.110391884	5.590709857	3.697236008	3.064767683	3.8505508705	3.3810018455	3.8505508705	3.3810018455	1.13887866569045	0.390714	0	0.878056662334387	0.390428	0	GO:0005829,cytosol;GO:0016281,eukaryotic translation initiation factor 4F complex;GO:0048471,perinuclear region of cytoplasm	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0004386,helicase activity;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0003743,translation initiation factor activity;GO:0016787,hydrolase activity;GO:0003676,nucleic acid binding	GO:1990830,cellular response to leukemia inhibitory factor;GO:0002183,cytoplasmic translational initiation;GO:1900260,negative regulation of RNA-directed 5'-3' RNA polymerase activity;GO:0006446,regulation of translational initiation;GO:0006413,translational initiation;GO:0016032,viral process	hsa:1974,path:hsa03013,RNA transport
HDAC6_HUMAN	Q9UBN7	HDAC6	Histone deacetylase 6	0.439993346	0.61006738	0.67576746	0.624674231	0.525030363	0.6502208455	0.525030363	0.6502208455	0.807464673939003	0.491029	0	1.23844427165063	0.491130	0	GO:0016235,aggresome;GO:0030424,axon;GO:0005901,caveola;GO:0031252,cell leading edge;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0000118,histone deacetylase complex;GO:0016234,inclusion body;GO:0005874,microtubule;GO:0005875,microtubule associated complex;GO:0005771,multivesicular body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0043204,perikaryon;GO:0048471,perinuclear region of cytoplasm;GO:0016021,integral component of membrane	GO:0003779,actin binding;GO:0043014,alpha-tubulin binding;GO:0008013,beta-catenin binding;GO:0048487,beta-tubulin binding;GO:0070840,dynein complex binding;GO:0019899,enzyme binding;GO:0004407,histone deacetylase activity;GO:0042826,histone deacetylase binding;GO:0051879,Hsp90 protein binding;GO:0008017,microtubule binding;GO:0051787,misfolded protein binding;GO:0032041,NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0031593,polyubiquitin modification-dependent protein binding;GO:0033558,protein deacetylase activity;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001226,RNA polymerase II transcription corepressor binding;GO:0048156,tau protein binding;GO:0042903,tubulin deacetylase activity;GO:0043130,ubiquitin binding;GO:0031625,ubiquitin protein ligase binding;GO:0008270,zinc ion binding;GO:0016787,hydrolase activity	GO:0035973,aggrephagy;GO:0070842,aggresome assembly;GO:0070301,cellular response to hydrogen peroxide;GO:0071218,cellular response to misfolded protein;GO:0035967,cellular response to topologically incorrect protein;GO:0060271,cilium assembly;GO:0048668,collateral sprouting;GO:0060997,dendritic spine morphogenesis;GO:0016575,histone deacetylation;GO:0070846,Hsp90 deacetylation;GO:0006886,intracellular protein transport;GO:0032418,lysosome localization;GO:0051646,mitochondrion localization;GO:0010727,negative regulation of hydrogen peroxide metabolic process;GO:0007026,negative regulation of microtubule depolymerization;GO:0051354,negative regulation of oxidoreductase activity;GO:0031333,negative regulation of protein-containing complex assembly;GO:0043242,negative regulation of protein-containing complex disassembly;GO:0045861,negative regulation of proteolysis;GO:0045892,negative regulation of transcription, DNA-templated;GO:0061734,parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization;GO:0034983,peptidyl-lysine deacetylation;GO:0070845,polyubiquitinated misfolded protein transport;GO:0010634,positive regulation of epithelial cell migration;GO:1901300,positive regulation of hydrogen peroxide-mediated programmed cell death;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:2000273,positive regulation of signaling receptor activity;GO:0006476,protein deacetylation;GO:0031648,protein destabilization;GO:0000209,protein polyubiquitination;GO:0006515,protein quality control for misfolded or incompletely synthesized proteins;GO:0032984,protein-containing complex disassembly;GO:0060765,regulation of androgen receptor signaling pathway;GO:0010506,regulation of autophagy;GO:1903146,regulation of autophagy of mitochondrion;GO:0070201,regulation of establishment of protein localization;GO:0045598,regulation of fat cell differentiation;GO:0040029,regulation of gene expression, epigenetic;GO:0016241,regulation of macroautophagy;GO:0060632,regulation of microtubule-based movement;GO:0031647,regulation of protein stability;GO:0070848,response to growth factor;GO:0051788,response to misfolded protein;GO:0090042,tubulin deacetylation;GO:0043162,ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	hsa:10013,path:hsa05203,Viral carcinogenesis;hsa:10013,path:hsa05034,Alcoholism
NFS1_HUMAN	Q9Y697	NFS1	Cysteine desulfurase, mitochondrial	0.068912787	2.55E-05	0.080266748	0.120322761	0.0344691435	0.1002947545	0.0344691435	0.1002947545	0.343678427369798	0.092109	0	2.90969674079659	0.092399	0	GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0031071,cysteine desulfurase activity;GO:0051536,iron-sulfur cluster binding;GO:0046872,metal ion binding;GO:0042803,protein homodimerization activity;GO:0030170,pyridoxal phosphate binding;GO:0003824,catalytic activity	GO:0044571,[2Fe-2S] cluster assembly;GO:0018283,iron incorporation into metallo-sulfur cluster;GO:0016226,iron-sulfur cluster assembly;GO:0006777,Mo-molybdopterin cofactor biosynthetic process;GO:0032324,molybdopterin cofactor biosynthetic process	hsa:9054,path:hsa00730,Thiamine metabolism;hsa:9054,path:hsa04122,Sulfur relay system
LAP2A_HUMAN	P42166	TMPO	Lamina-associated polypeptide 2, isoform alpha	0.246108191	0.058012332	0.173642924	0.165391332	0.1520602615	0.169517128	0.1520602615	0.169517128	0.897020043307954	0.469611	0	1.11480229172169	0.469493	0	GO:0005737,cytoplasm;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0005637,nuclear inner membrane;GO:0031965,nuclear membrane;GO:0005634,nucleus;GO:0000785,chromatin	GO:0003677,DNA binding;GO:0005521,lamin binding;GO:0045296,cadherin binding	GO:0006355,regulation of transcription, DNA-templated	
PLPL6_HUMAN	Q8IY17	PNPLA6	Patatin-like phospholipase domain-containing protein 6	0.587010115	0.654514285	2.093914256	0.631547641	0.6207622	1.3627309485	0.6207622	1.3627309485	0.455528070807588	0.184779	0	2.19525439612786	0.185115	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0004622,lysophospholipase activity;GO:0102545,phosphatidyl phospholipase B activity	GO:0046475,glycerophospholipid catabolic process;GO:0046470,phosphatidylcholine metabolic process	hsa:10908,path:hsa00564,Glycerophospholipid metabolism
RL7_HUMAN	P18124	RPL7	60S ribosomal protein L7	3.414554389	9.094642815	1.327031533	1.133446612	6.254598602	1.2302390725	6.254598602	1.2302390725	5.08405133750944	0.061971	0	0.196693529158948	0.061537	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005634,nucleus;GO:0014069,postsynaptic density;GO:1990904,ribonucleoprotein complex	GO:0003677,DNA binding;GO:0042802,identical protein binding;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000463,maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0042273,ribosomal large subunit biogenesis;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6129,path:hsa03010,Ribosome
VP26A_HUMAN	O75436	VPS26A	Vacuolar protein sorting-associated protein 26A	3.048997147	2.874995579	4.35424757	2.978303553	2.961996363	3.6662755615	2.961996363	3.6662755615	0.807903364958237	0.491361	0	1.23777179718975	0.491461	0	GO:0005829,cytosol;GO:0005769,early endosome;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0005764,lysosome;GO:0030904,retromer complex;GO:0030906,retromer, cargo-selective complex;GO:0097422,tubular endosome;GO:0031982,vesicle		GO:0032456,endocytic recycling;GO:0006886,intracellular protein transport;GO:0016241,regulation of macroautophagy;GO:0042147,retrograde transport, endosome to Golgi;GO:0016055,Wnt signaling pathway	hsa:9559,path:hsa04144,Endocytosis
MTSS1_HUMAN	O43312	MTSS1	Protein MTSS 1	2.55E-05	0.017605181	0.045180284	0.074958814	0.0088153405	0.060069549	0.0088153405	0.060069549	0.14675223381484	0.004290	-1	6.81420632589291	0.004331	1	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0030139,endocytic vesicle;GO:0001726,ruffle	GO:0003785,actin monomer binding;GO:0042802,identical protein binding;GO:0005102,signaling receptor binding;GO:0003779,actin binding	GO:0030036,actin cytoskeleton organization;GO:0007155,cell adhesion;GO:0071498,cellular response to fluid shear stress;GO:2001013,epithelial cell proliferation involved in renal tubule morphogenesis;GO:0072102,glomerulus morphogenesis;GO:0030035,microspike assembly;GO:0050680,negative regulation of epithelial cell proliferation;GO:0072160,nephron tubule epithelial cell differentiation;GO:0007009,plasma membrane organization;GO:0061333,renal tubule morphogenesis;GO:0007169,transmembrane receptor protein tyrosine kinase signaling pathway	
LASP1_HUMAN	Q14847	LASP1	LIM and SH3 domain protein 1	5.405519551	11.57198113	3.018667968	4.378070937	8.4887503405	3.6983694525	8.4887503405	3.6983694525	2.29526834717982	0.192658	0	0.435678904921376	0.192094	0	GO:0030864,cortical actin cytoskeleton;GO:0005737,cytoplasm;GO:0005925,focal adhesion	GO:0051015,actin filament binding;GO:0045296,cadherin binding;GO:0015075,ion transmembrane transporter activity;GO:0046872,metal ion binding;GO:0003779,actin binding	GO:0006811,ion transport	
ADRO_HUMAN	P22570	FDXR	NADPH:adrenodoxin oxidoreductase, mitochondrial	0.076083408	0.206099495	0.227059242	0.173691073	0.1410914515	0.2003751575	0.1410914515	0.2003751575	0.704136447154134	0.408369	0	1.42017929059295	0.408561	0	GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0004324,ferredoxin-NADP+ reductase activity;GO:0015039,NADPH-adrenodoxin reductase activity;GO:0016491,oxidoreductase activity	GO:0006700,C21-steroid hormone biosynthetic process;GO:0008203,cholesterol metabolic process;GO:0006124,ferredoxin metabolic process;GO:0006091,generation of precursor metabolites and energy;GO:0006694,steroid biosynthetic process;GO:0016125,sterol metabolic process;GO:0006744,ubiquinone biosynthetic process	
DDX5_HUMAN	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	4.747360474	3.825062134	5.594244028	7.894480548	4.286211304	6.744362288	4.286211304	6.744362288	0.635525068341347	0.348854	0	1.57350205336494	0.349103	0	GO:0071013,catalytic step 2 spliceosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0005681,spliceosomal complex	GO:0050681,androgen receptor binding;GO:0005524,ATP binding;GO:0035500,MH2 domain binding;GO:0003730,mRNA 3'-UTR binding;GO:0036002,pre-mRNA binding;GO:0070878,primary miRNA binding;GO:1990841,promoter-specific chromatin binding;GO:0070412,R-SMAD binding;GO:0043021,ribonucleoprotein complex binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0046332,SMAD binding;GO:0003676,nucleic acid binding;GO:0016787,hydrolase activity;GO:0048306,calcium-dependent protein binding;GO:0005516,calmodulin binding;GO:0019899,enzyme binding	GO:0000380,alternative mRNA splicing, via spliceosome;GO:0030521,androgen receptor signaling pathway;GO:0030509,BMP signaling pathway;GO:0001837,epithelial to mesenchymal transition;GO:0030520,intracellular estrogen receptor signaling pathway;GO:0072332,intrinsic apoptotic signaling pathway by p53 class mediator;GO:0000398,mRNA splicing, via spliceosome;GO:0009299,mRNA transcription;GO:0045445,myoblast differentiation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0000956,nuclear-transcribed mRNA catabolic process;GO:0043517,positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:1903800,positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:0061614,pri-miRNA transcription by RNA polymerase II;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0060765,regulation of androgen receptor signaling pathway;GO:0045667,regulation of osteoblast differentiation;GO:2001014,regulation of skeletal muscle cell differentiation;GO:0006357,regulation of transcription by RNA polymerase II;GO:0048511,rhythmic process;GO:0045069,regulation of viral genome replication	hsa:1655,path:hsa03040,Spliceosome;hsa:1655,path:hsa05202,Transcriptional misregulation in cancer;hsa:1655,path:hsa05205,Proteoglycans in cancer
ELP1_HUMAN	O95163	ELP1	Elongator complex protein 1	0.110752176	0.078906792	0.147179338	0.038819525	0.094829484	0.0929994315	0.094829484	0.0929994315	1.01967810416131	0.426899	0	0.980701650765072	0.426689	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0033588,elongator holoenzyme complex;GO:0005634,nucleus	GO:0000049,tRNA binding	GO:0002926,tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation;GO:0002098,tRNA wobble uridine modification	
PYGL_HUMAN	P06737	PYGL	Glycogen phosphorylase, liver form	2.628844052	5.039081973	4.909103275	8.597482482	3.8339630125	6.7532928785	3.8339630125	6.7532928785	0.567717568522154	0.287453	0	1.76143923571563	0.287750	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0034774,secretory granule lumen	GO:0016208,AMP binding;GO:0005524,ATP binding;GO:0032052,bile acid binding;GO:0005536,glucose binding;GO:0008184,glycogen phosphorylase activity;GO:0042802,identical protein binding;GO:0102250,linear malto-oligosaccharide phosphorylase activity;GO:0002060,purine nucleobase binding;GO:0030170,pyridoxal phosphate binding;GO:0102499,SHG alpha-glucan phosphorylase activity;GO:0019842,vitamin binding	GO:0006015,5-phosphoribose 1-diphosphate biosynthetic process;GO:0042593,glucose homeostasis;GO:0005980,glycogen catabolic process;GO:0005977,glycogen metabolic process;GO:0070266,necroptotic process;GO:0043312,neutrophil degranulation;GO:0009617,response to bacterium	hsa:5836,path:hsa00500,Starch and sucrose metabolism;hsa:5836,path:hsa04217,Necroptosis;hsa:5836,path:hsa04910,Insulin signaling pathway;hsa:5836,path:hsa04922,Glucagon signaling pathway;hsa:5836,path:hsa04931,Insulin resistance
UBXN7_HUMAN	O94888	UBXN7	UBX domain-containing protein 7	0.081012923	0.087186827	0.240455123	0.11906997	0.084099875	0.1797625465	0.084099875	0.1797625465	0.467838694085255	0.195847	0	2.13748886666003	0.196182	0	GO:0005829,cytosol;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0034098,VCP-NPL4-UFD1 AAA ATPase complex	GO:0008134,transcription factor binding;GO:0043130,ubiquitin binding;GO:0031625,ubiquitin protein ligase binding	GO:0043687,post-translational protein modification	
SNX4_HUMAN	O95219	SNX4	Sorting nexin-4	0.168948898	0.212542022	0.3404331	0.200333678	0.19074546	0.270383389	0.19074546	0.270383389	0.705462938035739	0.409487	0	1.41750890951743	0.409677	0	GO:0005737,cytoplasm;GO:0005868,cytoplasmic dynein complex;GO:0031901,early endosome membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0031201,SNARE complex	GO:0005154,epidermal growth factor receptor binding;GO:0005158,insulin receptor binding;GO:1990460,leptin receptor binding;GO:0035091,phosphatidylinositol binding;GO:1990459,transferrin receptor binding	GO:0032456,endocytic recycling;GO:1903595,positive regulation of histamine secretion by mast cell;GO:0015031,protein transport	hsa:8723,path:hsa04144,Endocytosis
ITA6_HUMAN	P23229	ITGA6	Integrin alpha-6	0.531044815	0.330053512	0.647069769	3.208780088	0.4305491635	1.9279249285	0.4305491635	1.9279249285	0.223322577106249	0.023479	-1	4.47782760237554	0.023619	1	GO:0005912,adherens junction;GO:0009986,cell surface;GO:0030175,filopodium;GO:0005925,focal adhesion;GO:0034676,integrin alpha6-beta4 complex;GO:0005886,plasma membrane;GO:0016021,integral component of membrane;GO:0008305,integrin complex	GO:0045296,cadherin binding;GO:0031994,insulin-like growth factor I binding;GO:0043236,laminin binding;GO:0046872,metal ion binding;GO:0038132,neuregulin binding;GO:0044877,protein-containing complex binding	GO:0098609,cell-cell adhesion;GO:0031589,cell-substrate adhesion;GO:0007044,cell-substrate junction assembly;GO:0071407,cellular response to organic cyclic compound;GO:0030199,collagen fibril organization;GO:0010668,ectodermal cell differentiation;GO:0030198,extracellular matrix organization;GO:0031581,hemidesmosome assembly;GO:0007229,integrin-mediated signaling pathway;GO:0050900,leukocyte migration;GO:0035878,nail development;GO:2001237,negative regulation of extrinsic apoptotic signaling pathway;GO:0043065,positive regulation of apoptotic process;GO:0030335,positive regulation of cell migration;GO:0010811,positive regulation of cell-substrate adhesion;GO:0043547,positive regulation of GTPase activity;GO:0010976,positive regulation of neuron projection development;GO:0042327,positive regulation of phosphorylation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0043589,skin morphogenesis;GO:0007155,cell adhesion	hsa:3655,path:hsa04151,PI3K-Akt signaling pathway;hsa:3655,path:hsa04512,ECM-receptor interaction;hsa:3655,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3655,path:hsa04510,Focal adhesion;hsa:3655,path:hsa04810,Regulation of actin cytoskeleton;hsa:3655,path:hsa04640,Hematopoietic cell lineage;hsa:3655,path:hsa05200,Pathways in cancer;hsa:3655,path:hsa05222,Small cell lung cancer;hsa:3655,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:3655,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:3655,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:3655,path:hsa05165,Human papillomavirus infection;hsa:3655,path:hsa05145,Toxoplasmosis
DEN4C_HUMAN	Q5VZ89	DENND4C	DENN domain-containing protein 4C	0.109677426	1.041198092	0.118040488	0.170476997	0.575437759	0.1442587425	0.575437759	0.1442587425	3.98892815109628	0.091107	0	0.250693911276684	0.090599	0	GO:0031410,cytoplasmic vesicle;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0032593,insulin-responsive compartment;GO:0043231,intracellular membrane-bounded organelle;GO:0005886,plasma membrane;GO:0030904,retromer complex	GO:0005085,guanyl-nucleotide exchange factor activity	GO:0032869,cellular response to insulin stimulus;GO:0072659,protein localization to plasma membrane;GO:0015031,protein transport;GO:0032483,regulation of Rab protein signal transduction	
K1C13_HUMAN	P13646	KRT13	Keratin, type I cytoskeletal 13	5.060558088	8.771259533	5.759814803	5.073760058	6.9159088105	5.4167874305	6.9159088105	5.4167874305	1.27675469994613	0.354285	0	0.783235808759656	0.353927	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0045111,intermediate filament cytoskeleton;GO:0045095,keratin filament;GO:0005634,nucleus;GO:0005882,intermediate filament	GO:0005198,structural molecule activity	GO:0070268,cornification;GO:0007010,cytoskeleton organization;GO:0031424,keratinization	hsa:3860,path:hsa04915,Estrogen signaling pathway;hsa:3860,path:hsa05150,Staphylococcus aureus infection
PDCD6_HUMAN	O75340	PDCD6	Programmed cell death protein 6	3.253806143	16.8197364	0.14369403	0.438905706	10.0367712715	0.291299868	10.0367712715	0.291299868	34.4551178152267	0.000813	1	0.0290232645658832	0.000793	-1	GO:0030127,COPII vesicle coat;GO:0031463,Cul3-RING ubiquitin ligase complex;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005509,calcium ion binding;GO:0048306,calcium-dependent protein binding;GO:0042802,identical protein binding;GO:0000287,magnesium ion binding;GO:0046983,protein dimerization activity;GO:0042803,protein homodimerization activity;GO:0030674,protein-macromolecule adaptor activity;GO:0043495,protein-membrane adaptor activity;GO:1990756,ubiquitin ligase-substrate adaptor activity	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0001525,angiogenesis;GO:0097190,apoptotic signaling pathway;GO:0034605,cellular response to heat;GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0051898,negative regulation of protein kinase B signaling;GO:0032007,negative regulation of TOR signaling;GO:0030948,negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0014032,neural crest cell development;GO:0014029,neural crest formation;GO:0045766,positive regulation of angiogenesis;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0010595,positive regulation of endothelial cell migration;GO:0001938,positive regulation of endothelial cell proliferation;GO:1902527,positive regulation of protein monoubiquitination;GO:0051592,response to calcium ion;GO:0036324,vascular endothelial growth factor receptor-2 signaling pathway	
CUX1_HUMAN	P39880	CUX1	Homeobox protein cut-like 1	0.098883303	0.098294035	0.246358459	0.163609801	0.098588669	0.20498413	0.098588669	0.20498413	0.480957569739667	0.207740	0	2.07918548935882	0.208073	0	GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0030173,integral component of Golgi membrane;GO:0005654,nucleoplasm;GO:0000785,chromatin;GO:0005829,cytosol;GO:0005634,nucleus	GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0030674,protein-macromolecule adaptor activity;GO:0000977,RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0043565,sequence-specific DNA binding;GO:1990837,sequence-specific double-stranded DNA binding;GO:0003677,DNA binding	GO:0006891,intra-Golgi vesicle-mediated transport;GO:0007275,multicellular organism development;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0050775,positive regulation of dendrite morphogenesis;GO:0006357,regulation of transcription by RNA polymerase II;GO:0000301,retrograde transport, vesicle recycling within Golgi	
A1AG2_HUMAN	P19652	ORM2	Alpha-1-acid glycoprotein 2	0.613331029	0.701643738	1.333189333	3.893025833	0.6574873835	2.613107583	0.6574873835	2.613107583	0.251611295217002	0.035584	-1	3.97438437387141	0.035764	1	GO:0035578,azurophil granule lumen;GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0031093,platelet alpha granule lumen;GO:0035580,specific granule lumen		GO:0006953,acute-phase response;GO:0043312,neutrophil degranulation;GO:0002576,platelet degranulation;GO:0032731,positive regulation of interleukin-1 beta production;GO:0032732,positive regulation of interleukin-1 production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0002682,regulation of immune system process	
SCP2_HUMAN	P22307	SCP2	Sterol carrier protein 2	1.437895486	2.760268327	1.581952246	1.324135638	2.0990819065	1.453043942	2.0990819065	1.453043942	1.4446100670643	0.316365	0	0.692228320152975	0.315941	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005782,peroxisomal matrix;GO:0005777,peroxisome;GO:0032991,protein-containing complex	GO:0003988,acetyl-CoA C-acyltransferase activity;GO:0050633,acetyl-CoA C-myristoyltransferase activity;GO:0015485,cholesterol binding;GO:0120020,cholesterol transfer activity;GO:0000062,fatty-acyl-CoA binding;GO:0036042,long-chain fatty acyl-CoA binding;GO:0070538,oleic acid binding;GO:0120019,phosphatidylcholine transfer activity;GO:0008526,phosphatidylinositol transfer activity;GO:0033814,propanoyl-CoA C-acyltransferase activity;GO:0050632,propionyl-CoA C2-trimethyltridecanoyltransferase activity;GO:0005102,signaling receptor binding;GO:0032934,sterol binding;GO:0016747,transferase activity, transferring acyl groups other than amino-acyl groups	GO:0036109,alpha-linolenic acid metabolic process;GO:0006699,bile acid biosynthetic process;GO:0008206,bile acid metabolic process;GO:0006635,fatty acid beta-oxidation;GO:0033540,fatty acid beta-oxidation using acyl-CoA oxidase;GO:0032959,inositol trisphosphate biosynthetic process;GO:0032367,intracellular cholesterol transport;GO:1901373,lipid hydroperoxide transport;GO:0007031,peroxisome organization;GO:0015914,phospholipid transport;GO:0032385,positive regulation of intracellular cholesterol transport;GO:0045940,positive regulation of steroid metabolic process;GO:0006701,progesterone biosynthetic process;GO:0008104,protein localization;GO:0072659,protein localization to plasma membrane;GO:0071071,regulation of phospholipid biosynthetic process;GO:0006694,steroid biosynthetic process	hsa:6342,path:hsa00120,Primary bile acid biosynthesis;hsa:6342,path:hsa01040,Biosynthesis of unsaturated fatty acids;hsa:6342,path:hsa04146,Peroxisome;hsa:6342,path:hsa03320,PPAR signaling pathway
SYUA_HUMAN	P37840	SNCA	Alpha-synuclein	2.55E-05	1.617522144	0.028778526	0.036308338	0.808773822	0.032543432	0.808773822	0.032543432	24.8521367383747	0.002014	1	0.0402379888106715	0.001973	-1	GO:0015629,actin cytoskeleton;GO:0030424,axon;GO:0043679,axon terminus;GO:0005938,cell cortex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0030426,growth cone;GO:0016234,inclusion body;GO:0005764,lysosome;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0043025,neuronal cell body;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0099512,supramolecular fiber;GO:0045202,synapse;GO:0005856,cytoskeleton;GO:0005794,Golgi apparatus;GO:0005743,mitochondrial inner membrane;GO:0005758,mitochondrial intermembrane space;GO:0005759,mitochondrial matrix;GO:0005741,mitochondrial outer membrane;GO:0005640,nuclear outer membrane;GO:0098794,postsynapse;GO:0005840,ribosome;GO:0005791,rough endoplasmic reticulum;GO:0030672,synaptic vesicle membrane;GO:0043195,terminal bouton	GO:0003779,actin binding;GO:0043014,alpha-tubulin binding;GO:0005509,calcium ion binding;GO:0005507,copper ion binding;GO:1903136,cuprous ion binding;GO:0043027,cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0070840,dynein complex binding;GO:0008198,ferrous iron binding;GO:0042393,histone binding;GO:0030544,Hsp70 protein binding;GO:0042802,identical protein binding;GO:0019894,kinesin binding;GO:0000287,magnesium ion binding;GO:0016491,oxidoreductase activity;GO:0005543,phospholipid binding;GO:0051219,phosphoprotein binding;GO:0004860,protein kinase inhibitor activity;GO:0000149,SNARE binding;GO:0048156,tau protein binding;GO:0000976,transcription regulatory region sequence-specific DNA binding;GO:0008270,zinc ion binding;GO:0050544,arachidonic acid binding;GO:0048487,beta-tubulin binding;GO:0008017,microtubule binding;GO:0043274,phospholipase binding;GO:0019904,protein domain specific binding;GO:0047485,protein N-terminus binding	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:1990000,amyloid fibril formation;GO:0071280,cellular response to copper ion;GO:0071872,cellular response to epinephrine stimulus;GO:0034599,cellular response to oxidative stress;GO:0007268,chemical synaptic transmission;GO:0042416,dopamine biosynthetic process;GO:0051583,dopamine uptake involved in synaptic transmission;GO:0001774,microglial cell activation;GO:0043066,negative regulation of apoptotic process;GO:1904715,negative regulation of chaperone-mediated autophagy;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0051585,negative regulation of dopamine uptake involved in synaptic transmission;GO:0045920,negative regulation of exocytosis;GO:0035067,negative regulation of histone acetylation;GO:0031115,negative regulation of microtubule polymerization;GO:1902957,negative regulation of mitochondrial electron transport, NADH to ubiquinone;GO:0032769,negative regulation of monooxygenase activity;GO:1901215,negative regulation of neuron death;GO:0051622,negative regulation of norepinephrine uptake;GO:0010642,negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0006469,negative regulation of protein kinase activity;GO:0051612,negative regulation of serotonin uptake;GO:0070495,negative regulation of thrombin-activated receptor signaling pathway;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0032410,negative regulation of transporter activity;GO:0043065,positive regulation of apoptotic process;GO:0045807,positive regulation of endocytosis;GO:0045921,positive regulation of exocytosis;GO:1903284,positive regulation of glutathione peroxidase activity;GO:1903285,positive regulation of hydrogen peroxide catabolic process;GO:0050729,positive regulation of inflammatory response;GO:0060732,positive regulation of inositol phosphate biosynthetic process;GO:1901216,positive regulation of neuron death;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0071902,positive regulation of protein serine/threonine kinase activity;GO:0001921,positive regulation of receptor recycling;GO:0051281,positive regulation of release of sequestered calcium ion into cytosol;GO:0035543,positive regulation of SNARE complex assembly;GO:0031648,protein destabilization;GO:0051262,protein tetramerization;GO:0031623,receptor internalization;GO:0014059,regulation of dopamine secretion;GO:1901214,regulation of neuron death;GO:0051621,regulation of norepinephrine uptake;GO:0010517,regulation of phospholipase activity;GO:1905606,regulation of presynapse assembly;GO:1903426,regulation of reactive oxygen species biosynthetic process;GO:1903421,regulation of synaptic vesicle recycling;GO:0022898,regulation of transmembrane transporter activity;GO:0034341,response to interferon-gamma;GO:0070555,response to interleukin-1;GO:0010040,response to iron(II) ion;GO:0032496,response to lipopolysaccharide;GO:0032026,response to magnesium ion;GO:0035493,SNARE complex assembly;GO:0097435,supramolecular fiber organization;GO:0050808,synapse organization;GO:0048488,synaptic vesicle endocytosis;GO:0016079,synaptic vesicle exocytosis;GO:0016082,synaptic vesicle priming;GO:0008344,adult locomotory behavior;GO:0007568,aging;GO:0048148,behavioral response to cocaine;GO:0044344,cellular response to fibroblast growth factor stimulus;GO:0060079,excitatory postsynaptic potential;GO:0006631,fatty acid metabolic process;GO:0060291,long-term synaptic potentiation;GO:0042775,mitochondrial ATP synthesis coupled electron transport;GO:0007006,mitochondrial membrane organization;GO:0045963,negative regulation of dopamine metabolic process;GO:0043524,negative regulation of neuron apoptotic process;GO:0001933,negative regulation of protein phosphorylation;GO:0006638,neutral lipid metabolic process;GO:0006644,phospholipid metabolic process;GO:0001956,positive regulation of neurotransmitter secretion;GO:0051259,protein complex oligomerization;GO:0050812,regulation of acyl-CoA biosynthetic process;GO:0014048,regulation of glutamate secretion;GO:0040012,regulation of locomotion;GO:0048169,regulation of long-term neuronal synaptic plasticity;GO:0043030,regulation of macrophage activation;GO:2000377,regulation of reactive oxygen species metabolic process;GO:1904307,response to desipramine;GO:0042493,response to drug;GO:0001963,synaptic transmission, dopaminergic;GO:0048489,synaptic vesicle transport	hsa:6622,path:hsa05010,Alzheimer disease;hsa:6622,path:hsa05012,Parkinson disease
MYG1_HUMAN	Q9HB07	MYG1	MYG1 exonuclease	1.123581891	0.589336477	1.353260455	1.453876472	0.856459184	1.4035684635	0.856459184	1.4035684635	0.610201216593522	0.326154	0	1.63880368115709	0.326423	0	GO:0005737,cytoplasm;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0004518,nuclease activity	GO:0035641,locomotory exploration behavior	
TOR2A_HUMAN	Q5JU69	TOR2A	Torsin-2A	2.55E-05	2.55E-05	0.042711306	2.55E-05	2.55e-005	0.021368403	2.55e-005	0.021368403	0.00119335076187023	0.000000	-1	837.976588235294	0.000000	1	GO:0005576,extracellular region;GO:0005788,endoplasmic reticulum lumen;GO:0005635,nuclear envelope	GO:0005524,ATP binding;GO:0005179,hormone activity;GO:0016887,ATPase activity;GO:0042802,identical protein binding	GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0031640,killing of cells of other organism;GO:0051673,membrane disruption in other organism;GO:1904427,positive regulation of calcium ion transmembrane transport;GO:0043950,positive regulation of cAMP-mediated signaling;GO:0008284,positive regulation of cell population proliferation;GO:0010628,positive regulation of gene expression;GO:0030103,vasopressin secretion;GO:0030104,water homeostasis;GO:0051085,chaperone cofactor-dependent protein refolding	
SF3A1_HUMAN	Q15459	SF3A1	Splicing factor 3A subunit 1	2.348729333	1.245294888	3.124967434	10.45875737	1.7970121105	6.791862402	1.7970121105	6.791862402	0.264583114930425	0.042031	-1	3.7795306789058	0.042230	1	GO:0071013,catalytic step 2 spliceosome;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0005686,U2 snRNP;GO:0071005,U2-type precatalytic spliceosome;GO:0071004,U2-type prespliceosome;GO:0005684,U2-type spliceosomal complex	GO:0003723,RNA binding	GO:0000389,mRNA 3'-splice site recognition;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:1903241,U2-type prespliceosome assembly;GO:0006396,RNA processing	hsa:10291,path:hsa03040,Spliceosome
RASN_HUMAN	P01111	NRAS	GTPase NRas	0.458526835	1.678670197	0.065539304	2.55E-05	1.068598516	0.032782402	1.068598516	0.032782402	32.5967119797994	0.000953	1	0.0306779407880069	0.000930	-1	GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0070821,tertiary granule membrane	GO:0003925,G protein activity;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0044877,protein-containing complex binding	GO:0000165,MAPK cascade;GO:0043312,neutrophil degranulation;GO:0001938,positive regulation of endothelial cell proliferation;GO:0007265,Ras protein signal transduction;GO:0002223,stimulatory C-type lectin receptor signaling pathway	hsa:4893,path:hsa04014,Ras signaling pathway;hsa:4893,path:hsa04015,Rap1 signaling pathway;hsa:4893,path:hsa04010,MAPK signaling pathway;hsa:4893,path:hsa04012,ErbB signaling pathway;hsa:4893,path:hsa04370,VEGF signaling pathway;hsa:4893,path:hsa04371,Apelin signaling pathway;hsa:4893,path:hsa04068,FoxO signaling pathway;hsa:4893,path:hsa04072,Phospholipase D signaling pathway;hsa:4893,path:hsa04071,Sphingolipid signaling pathway;hsa:4893,path:hsa04151,PI3K-Akt signaling pathway;hsa:4893,path:hsa04150,mTOR signaling pathway;hsa:4893,path:hsa04140,Autophagy - animal;hsa:4893,path:hsa04137,Mitophagy - animal;hsa:4893,path:hsa04210,Apoptosis;hsa:4893,path:hsa04218,Cellular senescence;hsa:4893,path:hsa04540,Gap junction;hsa:4893,path:hsa04550,Signaling pathways regulating pluripotency of stem cells;hsa:4893,path:hsa04810,Regulation of actin cytoskeleton;hsa:4893,path:hsa04625,C-type lectin receptor signaling pathway;hsa:4893,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:4893,path:hsa04660,T cell receptor signaling pathway;hsa:4893,path:hsa04662,B cell receptor signaling pathway;hsa:4893,path:hsa04664,Fc epsilon RI signaling pathway;hsa:4893,path:hsa04062,Chemokine signaling pathway;hsa:4893,path:hsa04910,Insulin signaling pathway;hsa:4893,path:hsa04929,GnRH secretion;hsa:4893,path:hsa04912,GnRH signaling pathway;hsa:4893,path:hsa04915,Estrogen signaling pathway;hsa:4893,path:hsa04917,Prolactin signaling pathway;hsa:4893,path:hsa04921,Oxytocin signaling pathway;hsa:4893,path:hsa04926,Relaxin signaling pathway;hsa:4893,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:4893,path:hsa04919,Thyroid hormone signaling pathway;hsa:4893,path:hsa04916,Melanogenesis;hsa:4893,path:hsa04725,Cholinergic synapse;hsa:4893,path:hsa04726,Serotonergic synapse;hsa:4893,path:hsa04720,Long-term potentiation;hsa:4893,path:hsa04730,Long-term depression;hsa:4893,path:hsa04722,Neurotrophin signaling pathway;hsa:4893,path:hsa04360,Axon guidance;hsa:4893,path:hsa04211,Longevity regulating pathway;hsa:4893,path:hsa04213,Longevity regulating pathway - multiple species;hsa:4893,path:hsa04714,Thermogenesis;hsa:4893,path:hsa05200,Pathways in cancer;hsa:4893,path:hsa05206,MicroRNAs in cancer;hsa:4893,path:hsa05205,Proteoglycans in cancer;hsa:4893,path:hsa05203,Viral carcinogenesis;hsa:4893,path:hsa05230,Central carbon metabolism in cancer;hsa:4893,path:hsa05231,Choline metabolism in cancer;hsa:4893,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:4893,path:hsa05210,Colorectal cancer;hsa:4893,path:hsa05225,Hepatocellular carcinoma;hsa:4893,path:hsa05226,Gastric cancer;hsa:4893,path:hsa05214,Glioma;hsa:4893,path:hsa05216,Thyroid cancer;hsa:4893,path:hsa05221,Acute myeloid leukemia;hsa:4893,path:hsa05220,Chronic myeloid leukemia;hsa:4893,path:hsa05218,Melanoma;hsa:4893,path:hsa05211,Renal cell carcinoma;hsa:4893,path:hsa05219,Bladder cancer;hsa:4893,path:hsa05215,Prostate cancer;hsa:4893,path:hsa05213,Endometrial cancer;hsa:4893,path:hsa05224,Breast cancer;hsa:4893,path:hsa05223,Non-small cell lung cancer;hsa:4893,path:hsa05034,Alcoholism;hsa:4893,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:4893,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:4893,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:4893,path:hsa05161,Hepatitis B;hsa:4893,path:hsa05160,Hepatitis C;hsa:4893,path:hsa05163,Human cytomegalovirus infection;hsa:4893,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:4893,path:hsa05165,Human papillomavirus infection;hsa:4893,path:hsa01521,EGFR tyrosine kinase inhibitor resistance;hsa:4893,path:hsa01522,Endocrine resistance
ZO1_HUMAN	Q07157	TJP1	Tight junction protein ZO-1	7.286213058	13.16432001	7.524842569	19.35876242	10.225266534	13.4418024945	10.225266534	13.4418024945	0.760706500350968	0.454758	0	1.31456744426218	0.454900	0	GO:0005912,adherens junction;GO:0043296,apical junction complex;GO:0045177,apical part of cell;GO:0016323,basolateral plasma membrane;GO:0005923,bicellular tight junction;GO:0030054,cell junction;GO:0042995,cell projection;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005921,gap junction;GO:0005886,plasma membrane;GO:0002102,podosome;GO:0032991,protein-containing complex;GO:0070160,tight junction	GO:0045296,cadherin binding;GO:0005516,calmodulin binding;GO:0050839,cell adhesion molecule binding;GO:0008022,protein C-terminus binding	GO:0031032,actomyosin structure organization;GO:0034334,adherens junction maintenance;GO:0098609,cell-cell adhesion;GO:0007043,cell-cell junction assembly;GO:0045216,cell-cell junction organization;GO:0090557,establishment of endothelial intestinal barrier;GO:0035329,hippo signaling;GO:0035633,maintenance of blood-brain barrier;GO:2000250,negative regulation of actin cytoskeleton reorganization;GO:0043066,negative regulation of apoptotic process;GO:0051497,negative regulation of stress fiber assembly;GO:1905605,positive regulation of blood-brain barrier permeability;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:2000049,positive regulation of cell-cell adhesion mediated by cadherin;GO:1903672,positive regulation of sprouting angiogenesis;GO:0071896,protein localization to adherens junction;GO:1902396,protein localization to bicellular tight junction;GO:0150105,protein localization to cell-cell junction;GO:2000810,regulation of bicellular tight junction assembly;GO:1901888,regulation of cell junction assembly;GO:0051493,regulation of cytoskeleton organization;GO:0071333,cellular response to glucose stimulus;GO:0043116,negative regulation of vascular permeability;GO:0042493,response to drug;GO:0045471,response to ethanol;GO:0032496,response to lipopolysaccharide;GO:0071000,response to magnetism	hsa:7082,path:hsa04520,Adherens junction;hsa:7082,path:hsa04530,Tight junction;hsa:7082,path:hsa04540,Gap junction;hsa:7082,path:hsa05110,Vibrio cholerae infection;hsa:7082,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:7082,path:hsa05130,Pathogenic Escherichia coli infection
IFIT5_HUMAN	Q13325	IFIT5	Interferon-induced protein with tetratricopeptide repeats 5	0.136193015	0.108867242	0.26951074	1.401449799	0.1225301285	0.8354802695	0.1225301285	0.8354802695	0.146658314951386	0.004278	-1	6.81857009151835	0.004319	1	GO:0015629,actin cytoskeleton;GO:0045177,apical part of cell;GO:0005829,cytosol;GO:0005886,plasma membrane;GO:0032587,ruffle membrane	GO:0003690,double-stranded DNA binding;GO:0008266,poly(U) RNA binding;GO:0003723,RNA binding;GO:0000339,RNA cap binding;GO:0003727,single-stranded RNA binding;GO:0000049,tRNA binding	GO:0051607,defense response to virus;GO:0045071,negative regulation of viral genome replication;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0060337,type I interferon signaling pathway	
SLIRP_HUMAN	Q9GZT3	SLIRP	SRA stem-loop-interacting RNA-binding protein, mitochondrial	0.258728475	0.301638997	0.154812422	0.055133463	0.280183736	0.1049729425	0.280183736	0.1049729425	2.66910433610071	0.159789	0	0.374657515809554	0.159219	0	GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0001669,acrosomal vesicle;GO:0048471,perinuclear region of cytoplasm;GO:1990904,ribonucleoprotein complex;GO:0036126,sperm flagellum	GO:0003723,RNA binding;GO:0003676,nucleic acid binding	GO:0070584,mitochondrion morphogenesis;GO:0000961,negative regulation of mitochondrial RNA catabolic process;GO:0030317,flagellated sperm motility;GO:0007338,single fertilization;GO:0007286,spermatid development	
NDUB4_HUMAN	O95168	NDUFB4	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	0.423811783	2.843589433	0.212459368	0.203286313	1.633700608	0.2078728405	1.633700608	0.2078728405	7.85913447889793	0.028354	1	0.127240474467645	0.028070	-1	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0008137,NADH dehydrogenase (ubiquinone) activity	GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0006979,response to oxidative stress	hsa:4710,path:hsa00190,Oxidative phosphorylation;hsa:4710,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4710,path:hsa04714,Thermogenesis;hsa:4710,path:hsa05010,Alzheimer disease;hsa:4710,path:hsa05012,Parkinson disease;hsa:4710,path:hsa05016,Huntington disease;hsa:4710,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
CAH4_HUMAN	P22748	CA4	Carbonic anhydrase 4	0.101877542	0.218467539	0.098871176	3.306426196	0.1601725405	1.702648686	0.1601725405	1.702648686	0.0940725716449999	0.000470	-1	10.6300910298666	0.000477	1	GO:0031362,anchored component of external side of plasma membrane;GO:0016324,apical plasma membrane;GO:0031526,brush border membrane;GO:0009986,cell surface;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0005791,rough endoplasmic reticulum;GO:0030667,secretory granule membrane;GO:0005802,trans-Golgi network;GO:0030658,transport vesicle membrane;GO:0031225,anchored component of membrane;GO:0016021,integral component of membrane	GO:0004089,carbonate dehydratase activity;GO:0016836,hydro-lyase activity;GO:0008270,zinc ion binding	GO:0015701,bicarbonate transport;GO:0006730,one-carbon metabolic process	hsa:762,path:hsa00910,Nitrogen metabolism;hsa:762,path:hsa04964,Proximal tubule bicarbonate reclamation
MYO1B_HUMAN	O43795	MYO1B	Unconventional myosin-Ib	5.826429111	7.247580309	7.032164579	64.79808354	6.53700471	35.9151240595	6.53700471	35.9151240595	0.182012588879555	0.010745	-1	5.49412546767157	0.010827	1	GO:0015629,actin cytoskeleton;GO:0005884,actin filament;GO:0045177,apical part of cell;GO:0005903,brush border;GO:0071944,cell periphery;GO:0005737,cytoplasm;GO:0005769,early endosome;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0030175,filopodium;GO:0005902,microvillus;GO:0016459,myosin complex;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0031982,vesicle	GO:0051015,actin filament binding;GO:0030898,actin-dependent ATPase activity;GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0005516,calmodulin binding;GO:0000146,microfilament motor activity;GO:0005547,phosphatidylinositol-3,4,5-trisphosphate binding;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding;GO:0003774,motor activity;GO:0003779,actin binding	GO:0051017,actin filament bundle assembly;GO:0007015,actin filament organization;GO:0030048,actin filament-based movement;GO:0006892,post-Golgi vesicle-mediated transport;GO:0030050,vesicle transport along actin filament	hsa:4430,path:hsa05130,Pathogenic Escherichia coli infection
FCGR1_HUMAN	P12314	FCGR1A	High affinity immunoglobulin gamma Fc receptor I	0.272918361	0.253135996	0.381313466	0.252826625	0.2630271785	0.3170700455	0.2630271785	0.3170700455	0.829555431782344	0.495872	0	1.20546495350099	0.495813	0	GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0031901,early endosome membrane;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0019864,IgG binding;GO:0004888,transmembrane signaling receptor activity	GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0007166,cell surface receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0006911,phagocytosis, engulfment;GO:0061098,positive regulation of protein tyrosine kinase activity;GO:0006898,receptor-mediated endocytosis;GO:0050776,regulation of immune response;GO:0007165,signal transduction	hsa:2209,path:hsa04145,Phagosome;hsa:2209,path:hsa04640,Hematopoietic cell lineage;hsa:2209,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:2209,path:hsa04380,Osteoclast differentiation;hsa:2209,path:hsa05202,Transcriptional misregulation in cancer;hsa:2209,path:hsa05221,Acute myeloid leukemia;hsa:2209,path:hsa05322,Systemic lupus erythematosus;hsa:2209,path:hsa05150,Staphylococcus aureus infection;hsa:2209,path:hsa05152,Tuberculosis;hsa:2209,path:hsa05140,Leishmaniasis
RU2A_HUMAN	P09661	SNRPA1	U2 small nuclear ribonucleoprotein A'	25.95368454	4.128622867	9.093844557	16.6128137	15.0411537035	12.8533291285	15.0411537035	12.8533291285	1.17021462324098	0.381960	0	0.854544098270141	0.381657	0	GO:0071013,catalytic step 2 spliceosome;GO:0016604,nuclear body;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0030532,small nuclear ribonucleoprotein complex;GO:0005681,spliceosomal complex;GO:0005686,U2 snRNP;GO:0071007,U2-type catalytic step 2 spliceosome;GO:0071005,U2-type precatalytic spliceosome	GO:0003723,RNA binding;GO:0030620,U2 snRNA binding	GO:0035722,interleukin-12-mediated signaling pathway;GO:0000398,mRNA splicing, via spliceosome;GO:0008380,RNA splicing;GO:0007283,spermatogenesis	hsa:6627,path:hsa03040,Spliceosome
ITIH1_HUMAN	P19827	ITIH1	Inter-alpha-trypsin inhibitor heavy chain H1	3.364426898	2.146188431	3.528956627	17.59268038	2.7553076645	10.5608185035	2.7553076645	10.5608185035	0.260899064176404	0.040144	-1	3.83289991153001	0.040338	1	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region	GO:0005509,calcium ion binding;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0030212,hyaluronan metabolic process	
DHX15_HUMAN	O43143	DHX15	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15	6.232145426	3.498213747	7.105387474	5.693716655	4.8651795865	6.3995520645	4.8651795865	6.3995520645	0.760237519355211	0.454385	0	1.31537838443983	0.454527	0	GO:0016607,nuclear speck;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0005689,U12-type spliceosomal complex	GO:0005524,ATP binding;GO:0003725,double-stranded RNA binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity	GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0043279,response to alkaloid;GO:0009636,response to toxic substance;GO:0008380,RNA splicing	hsa:1665,path:hsa03040,Spliceosome
PUS7_HUMAN	Q96PZ0	PUS7	Pseudouridylate synthase 7 homolog	0.015793047	0.005764452	0.027690452	2.55E-05	0.0107787495	0.013857976	0.0107787495	0.013857976	0.777801137770768	0.468243	0	1.28567567137542	0.468370	0	GO:0005634,nucleus	GO:0019899,enzyme binding;GO:0009982,pseudouridine synthase activity;GO:0003723,RNA binding	GO:1990481,mRNA pseudouridine synthesis;GO:0017148,negative regulation of translation;GO:0001522,pseudouridine synthesis;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:2000380,regulation of mesoderm development;GO:0031119,tRNA pseudouridine synthesis;GO:0008033,tRNA processing	
SPB9_HUMAN	P50453	SERPINB9	Serpin B9	4.985794879	4.828985947	8.179441147	9.075674329	4.907390413	8.627557738	4.907390413	8.627557738	0.568804123023766	0.288450	0	1.75807445748458	0.288747	0	GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005794,Golgi apparatus;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0043027,cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0002020,protease binding;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0071391,cellular response to estrogen stimulus;GO:0006955,immune response;GO:0002448,mast cell mediated immunity;GO:0033668,negative regulation by symbiont of host apoptotic process;GO:0043066,negative regulation of apoptotic process;GO:0010951,negative regulation of endopeptidase activity;GO:0010628,positive regulation of gene expression;GO:0042270,protection from natural killer cell mediated cytotoxicity;GO:0009617,response to bacterium	hsa:5272,path:hsa05146,Amoebiasis
SC24D_HUMAN	O94855	SEC24D	Protein transport protein Sec24D	1.132658921	1.378800976	1.373541371	0.662754367	1.2557299485	1.018147869	1.2557299485	1.018147869	1.23334732285336	0.365189	0	0.810801614006421	0.364852	0	GO:0030127,COPII vesicle coat;GO:0005829,cytosol;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0043231,intracellular membrane-bounded organelle	GO:0000149,SNARE binding;GO:0008270,zinc ion binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0048208,COPII vesicle coating;GO:0090110,COPII-coated vesicle cargo loading;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0001701,in utero embryonic development;GO:0006886,intracellular protein transport	hsa:9871,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:9871,path:hsa05130,Pathogenic Escherichia coli infection
TBCD5_HUMAN	Q92609	TBC1D5	TBC1 domain family member 5	0.086044691	0.108844166	0.255397984	0.167179316	0.0974444285	0.21128865	0.0974444285	0.21128865	0.461191022328933	0.189858	0	2.16829892947651	0.190193	0	GO:0005776,autophagosome;GO:0005829,cytosol;GO:0010008,endosome membrane;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0030904,retromer complex	GO:0035612,AP-2 adaptor complex binding;GO:0005096,GTPase activator activity;GO:0044877,protein-containing complex binding;GO:1905394,retromer complex binding	GO:0090630,activation of GTPase activity;GO:0006914,autophagy;GO:0006886,intracellular protein transport;GO:0016236,macroautophagy;GO:0002092,positive regulation of receptor internalization;GO:0042594,response to starvation;GO:0042147,retrograde transport, endosome to Golgi	
STAB1_HUMAN	Q9NY15	STAB1	Stabilin-1	0.11275076	0.620399686	0.752965271	1.28581977	0.366575223	1.0193925205	0.366575223	1.0193925205	0.359601640808782	0.104076	0	2.78085494201554	0.104378	0	GO:0030666,endocytic vesicle membrane;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0005509,calcium ion binding;GO:0005540,hyaluronic acid binding;GO:0030169,low-density lipoprotein particle binding;GO:0005041,low-density lipoprotein particle receptor activity;GO:0015035,protein disulfide oxidoreductase activity;GO:0005044,scavenger receptor activity	GO:0007155,cell adhesion;GO:0007267,cell-cell signaling;GO:0042742,defense response to bacterium;GO:0006954,inflammatory response;GO:0016525,negative regulation of angiogenesis;GO:0006898,receptor-mediated endocytosis	
HCLS1_HUMAN	P14317	HCLS1	Hematopoietic lineage cell-specific protein	0.887499444	0.802395528	1.333549753	0.092665758	0.844947486	0.7131077555	0.844947486	0.7131077555	1.184880516981	0.377964	0	0.843966953349809	0.377652	0	GO:0030864,cortical actin cytoskeleton;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0030427,site of polarized growth;GO:0005667,transcription regulator complex	GO:0051015,actin filament binding;GO:0019901,protein kinase binding;GO:0001085,RNA polymerase II transcription factor binding;GO:0017124,SH3 domain binding;GO:0003779,actin binding	GO:0030041,actin filament polymerization;GO:0071345,cellular response to cytokine stimulus;GO:0030218,erythrocyte differentiation;GO:0035556,intracellular signal transduction;GO:2000107,negative regulation of leukocyte apoptotic process;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:2000251,positive regulation of actin cytoskeleton reorganization;GO:0008284,positive regulation of cell population proliferation;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0030854,positive regulation of granulocyte differentiation;GO:0045651,positive regulation of macrophage differentiation;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0014068,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0042307,positive regulation of protein import into nucleus;GO:0051897,positive regulation of protein kinase B signaling;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0042531,positive regulation of tyrosine phosphorylation of STAT protein;GO:0030833,regulation of actin filament polymerization;GO:0006355,regulation of transcription, DNA-templated;GO:0009725,response to hormone	hsa:3059,path:hsa04530,Tight junction;hsa:3059,path:hsa05205,Proteoglycans in cancer;hsa:3059,path:hsa05130,Pathogenic Escherichia coli infection;hsa:3059,path:hsa05131,Shigellosis;hsa:3059,path:hsa05100,Bacterial invasion of epithelial cells
NDUBA_HUMAN	O96000	NDUFB10	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	1.198249123	1.80923806	0.179377154	0.026684227	1.5037435915	0.1030306905	1.5037435915	0.1030306905	14.5951034997674	0.007606	1	0.0685161294002429	0.007490	-1	GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0070469,respirasome	GO:0008137,NADH dehydrogenase (ubiquinone) activity	GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly	hsa:4716,path:hsa00190,Oxidative phosphorylation;hsa:4716,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4716,path:hsa04714,Thermogenesis;hsa:4716,path:hsa05010,Alzheimer disease;hsa:4716,path:hsa05012,Parkinson disease;hsa:4716,path:hsa05016,Huntington disease;hsa:4716,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
GSTP1_HUMAN	P09211	GSTP1	Glutathione S-transferase P	44.39169705	170.1558618	19.00715069	19.92131107	107.273779425	19.46423088	107.273779425	19.46423088	5.51132896472301	0.054087	0	0.18144444042459	0.053681	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0034774,secretory granule lumen;GO:0097057,TRAF2-GSTP1 complex;GO:0031982,vesicle	GO:0035731,dinitrosyl-iron complex binding;GO:0005504,fatty acid binding;GO:0004602,glutathione peroxidase activity;GO:0004364,glutathione transferase activity;GO:0008432,JUN kinase binding;GO:0019207,kinase regulator activity;GO:0070026,nitric oxide binding;GO:0035730,S-nitrosoglutathione binding	GO:0031100,animal organ regeneration;GO:0071460,cellular response to cell-matrix adhesion;GO:0071364,cellular response to epidermal growth factor stimulus;GO:0071385,cellular response to glucocorticoid stimulus;GO:0032869,cellular response to insulin stimulus;GO:0071222,cellular response to lipopolysaccharide;GO:0034599,cellular response to oxidative stress;GO:0007417,central nervous system development;GO:0035726,common myeloid progenitor cell proliferation;GO:1901687,glutathione derivative biosynthetic process;GO:0006749,glutathione metabolic process;GO:0051122,hepoxilin biosynthetic process;GO:0043651,linoleic acid metabolic process;GO:0002674,negative regulation of acute inflammatory response;GO:0043066,negative regulation of apoptotic process;GO:0009890,negative regulation of biosynthetic process;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:2001237,negative regulation of extrinsic apoptotic signaling pathway;GO:0048147,negative regulation of fibroblast proliferation;GO:0043124,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0032691,negative regulation of interleukin-1 beta production;GO:0043508,negative regulation of JUN kinase activity;GO:0070664,negative regulation of leukocyte proliferation;GO:0043407,negative regulation of MAP kinase activity;GO:0043409,negative regulation of MAPK cascade;GO:0071638,negative regulation of monocyte chemotactic protein-1 production;GO:0051771,negative regulation of nitric-oxide synthase biosynthetic process;GO:0006469,negative regulation of protein kinase activity;GO:0071672,negative regulation of smooth muscle cell chemotaxis;GO:0032873,negative regulation of stress-activated MAPK cascade;GO:0032720,negative regulation of tumor necrosis factor production;GO:0010804,negative regulation of tumor necrosis factor-mediated signaling pathway;GO:1904706,negative regulation of vascular associated smooth muscle cell proliferation;GO:0043312,neutrophil degranulation;GO:0035732,nitric oxide storage;GO:0014003,oligodendrocyte development;GO:0032930,positive regulation of superoxide anion generation;GO:0006693,prostaglandin metabolic process;GO:0070372,regulation of ERK1 and ERK2 cascade;GO:0032872,regulation of stress-activated MAPK cascade;GO:0043200,response to amino acid;GO:0032355,response to estradiol;GO:0045471,response to ethanol;GO:0033591,response to L-ascorbic acid;GO:0000302,response to reactive oxygen species;GO:0006805,xenobiotic metabolic process	hsa:2950,path:hsa00480,Glutathione metabolism;hsa:2950,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:2950,path:hsa00982,Drug metabolism - cytochrome P450;hsa:2950,path:hsa00983,Drug metabolism - other enzymes;hsa:2950,path:hsa05200,Pathways in cancer;hsa:2950,path:hsa05204,Chemical carcinogenesis;hsa:2950,path:hsa05225,Hepatocellular carcinoma;hsa:2950,path:hsa05215,Prostate cancer;hsa:2950,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:2950,path:hsa01524,Platinum drug resistance
K2C72_HUMAN	Q14CN4	KRT72	Keratin, type II cytoskeletal 72	1.742042456	0.857962736	1.267760994	1.790969185	1.300002596	1.5293650895	1.300002596	1.5293650895	0.850027638871379	0.487677	0	1.17643233498589	0.487599	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0045095,keratin filament		GO:0070268,cornification;GO:0031424,keratinization	
NT5D1_HUMAN	Q5TFE4	NT5DC1	5'-nucleotidase domain-containing protein 1	0.743882	0.479632154	0.778786322	0.408113125	0.611757077	0.5934497235	0.611757077	0.5934497235	1.03084903872232	0.423300	0	0.970074145133265	0.423082	0		GO:0008253,5'-nucleotidase activity;GO:0046872,metal ion binding;GO:0016787,hydrolase activity		
CD2AP_HUMAN	Q9Y5K6	CD2AP	CD2-associated protein	0.438600137	0.42208345	0.553035513	0.372914714	0.4303417935	0.4629751135	0.4303417935	0.4629751135	0.929513878719531	0.457696	0	1.07583116604732	0.457552	0	GO:0015629,actin cytoskeleton;GO:0030424,axon;GO:0005911,cell-cell junction;GO:0034451,centriolar satellite;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0030139,endocytic vesicle;GO:0070062,extracellular exosome;GO:0001650,fibrillar center;GO:0031941,filamentous actin;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0001726,ruffle	GO:0008013,beta-catenin binding;GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0008022,protein C-terminus binding;GO:0044877,protein-containing complex binding;GO:0017124,SH3 domain binding;GO:0005200,structural constituent of cytoskeleton;GO:0005172,vascular endothelial growth factor receptor binding	GO:0007015,actin filament organization;GO:0007049,cell cycle;GO:0051301,cell division;GO:0098609,cell-cell adhesion;GO:0051058,negative regulation of small GTPase mediated signal transduction;GO:0032911,negative regulation of transforming growth factor beta1 production;GO:1900182,positive regulation of protein localization to nucleus;GO:0050714,positive regulation of protein secretion;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0065003,protein-containing complex assembly;GO:2000249,regulation of actin cytoskeleton reorganization;GO:0048259,regulation of receptor-mediated endocytosis;GO:0007165,signal transduction;GO:0006930,substrate-dependent cell migration, cell extension;GO:0016050,vesicle organization	hsa:23607,path:hsa05100,Bacterial invasion of epithelial cells
GRPE1_HUMAN	Q9HAV7	GRPEL1	GrpE protein homolog 1, mitochondrial	0.641764357	0.554792717	0.202860764	2.55E-05	0.598278537	0.101443132	0.598278537	0.101443132	5.89767414712708	0.048100	1	0.169558367426442	0.047718	-1	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0001405,PAM complex, Tim23 associated import motor	GO:0000774,adenyl-nucleotide exchange factor activity;GO:0051087,chaperone binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:0051082,unfolded protein binding	GO:0006457,protein folding;GO:0030150,protein import into mitochondrial matrix	
PCKGM_HUMAN	Q16822	PCK2	Phosphoenolpyruvate carboxykinase [GTP], mitochondrial	1.670839042	1.627433302	4.710782777	2.243900914	1.649136172	3.4773418455	1.649136172	3.4773418455	0.474251956026162	0.201649	0	2.10858381772248	0.201984	0	GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0005525,GTP binding;GO:0030145,manganese ion binding;GO:0004613,phosphoenolpyruvate carboxykinase (GTP) activity;GO:0004611,phosphoenolpyruvate carboxykinase activity;GO:0046872,metal ion binding	GO:0071549,cellular response to dexamethasone stimulus;GO:0071333,cellular response to glucose stimulus;GO:0032869,cellular response to insulin stimulus;GO:0071356,cellular response to tumor necrosis factor;GO:0006094,gluconeogenesis;GO:0046327,glycerol biosynthetic process from pyruvate;GO:0070365,hepatocyte differentiation;GO:0006116,NADH oxidation;GO:0006107,oxaloacetate metabolic process;GO:0032024,positive regulation of insulin secretion;GO:0019543,propionate catabolic process;GO:0033993,response to lipid;GO:0032496,response to lipopolysaccharide;GO:0042594,response to starvation	hsa:5106,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:5106,path:hsa00020,Citrate cycle (TCA cycle);hsa:5106,path:hsa00620,Pyruvate metabolism;hsa:5106,path:hsa04068,FoxO signaling pathway;hsa:5106,path:hsa04151,PI3K-Akt signaling pathway;hsa:5106,path:hsa04152,AMPK signaling pathway;hsa:5106,path:hsa04910,Insulin signaling pathway;hsa:5106,path:hsa04922,Glucagon signaling pathway;hsa:5106,path:hsa04920,Adipocytokine signaling pathway;hsa:5106,path:hsa03320,PPAR signaling pathway;hsa:5106,path:hsa04964,Proximal tubule bicarbonate reclamation;hsa:5106,path:hsa04931,Insulin resistance
SCRN2_HUMAN	Q96FV2	SCRN2	Secernin-2	0.235779574	0.257286522	0.405247157	0.266231151	0.246533048	0.335739154	0.246533048	0.335739154	0.734299366227628	0.433433	0	1.36184238471752	0.433598	0	GO:0070062,extracellular exosome	GO:0070004,cysteine-type exopeptidase activity;GO:0016805,dipeptidase activity		
ENOA_HUMAN	P06733	ENO1	Alpha-enolase	140.4677292	192.7226029	176.8557134	96.4529433	166.59516605	136.65432835	166.59516605	136.65432835	1.21909908058906	0.368877	0	0.820277872342263	0.368547	0	GO:0099738,cell cortex region;GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0031430,M band;GO:0016020,membrane;GO:0005634,nucleus;GO:0000015,phosphopyruvate hydratase complex;GO:0005886,plasma membrane	GO:0045296,cadherin binding;GO:0001227,DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0051020,GTPase binding;GO:0000287,magnesium ion binding;GO:0004634,phosphopyruvate hydratase activity;GO:0042803,protein homodimerization activity;GO:0003723,RNA binding;GO:0000977,RNA polymerase II transcription regulatory region sequence-specific DNA binding	GO:0061621,canonical glycolysis;GO:0006094,gluconeogenesis;GO:0006096,glycolytic process;GO:0044003,modulation by symbiont of host process;GO:0030308,negative regulation of cell growth;GO:1903298,negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:2001171,positive regulation of ATP biosynthetic process;GO:0045933,positive regulation of muscle contraction;GO:0010756,positive regulation of plasminogen activation;GO:0032889,regulation of vacuole fusion, non-autophagic;GO:0009615,response to virus	hsa:2023,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:2023,path:hsa03018,RNA degradation;hsa:2023,path:hsa04066,HIF-1 signaling pathway
DPYL1_HUMAN	Q14194	CRMP1	Dihydropyrimidinase-related protein 1	0.059792836	0.064297763	0.094058129	2.55E-05	0.0620452995	0.0470418145	0.0620452995	0.0470418145	1.31893933428099	0.344145	0	0.758184985471784	0.343769	0	GO:0005813,centrosome;GO:0005829,cytosol;GO:0030426,growth cone;GO:0030496,midbody;GO:0005634,nucleus;GO:0043204,perikaryon;GO:0005819,spindle	GO:0031005,filamin binding;GO:0016810,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0042802,identical protein binding	GO:0007411,axon guidance;GO:0000226,microtubule cytoskeleton organization;GO:1904530,negative regulation of actin filament binding;GO:0010977,negative regulation of neuron projection development;GO:0007399,nervous system development;GO:0006139,nucleobase-containing compound metabolic process	
RAC1_HUMAN	P63000	RAC1	Ras-related C3 botulinum toxin substrate 1	4.854241194	10.45836821	0.756724954	0.756437133	7.656304702	0.7565810435	7.656304702	0.7565810435	10.1196094823912	0.017061	1	0.0988180425084655	0.016856	-1	GO:0005938,cell cortex;GO:0042995,cell projection;GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0031410,cytoplasmic vesicle;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0101003,ficolin-1-rich granule membrane;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0000139,Golgi membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0030027,lamellipodium;GO:0042470,melanosome;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0098794,postsynapse;GO:0055038,recycling endosome membrane;GO:0032587,ruffle membrane;GO:0030667,secretory granule membrane;GO:0005802,trans-Golgi network	GO:0051117,ATPase binding;GO:0019899,enzyme binding;GO:0003925,G protein activity;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042826,histone deacetylase binding;GO:0019901,protein kinase binding;GO:0044877,protein-containing complex binding;GO:0051022,Rho GDP-dissociation inhibitor binding;GO:0031267,small GTPase binding;GO:0031996,thioesterase binding	GO:0030036,actin cytoskeleton organization;GO:0007015,actin filament organization;GO:0030041,actin filament polymerization;GO:0009653,anatomical structure morphogenesis;GO:0007596,blood coagulation;GO:0045453,bone resorption;GO:0007155,cell adhesion;GO:0048870,cell motility;GO:0008283,cell population proliferation;GO:0030031,cell projection assembly;GO:0007160,cell-matrix adhesion;GO:0071260,cellular response to mechanical stimulus;GO:0030865,cortical cytoskeleton organization;GO:0043652,engulfment of apoptotic cell;GO:0048013,ephrin receptor signaling pathway;GO:0007163,establishment or maintenance of cell polarity;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0048012,hepatocyte growth factor receptor signaling pathway;GO:0006954,inflammatory response;GO:0035556,intracellular signal transduction;GO:0030032,lamellipodium assembly;GO:0051668,localization within membrane;GO:0002551,mast cell chemotaxis;GO:0008045,motor neuron axon guidance;GO:0010764,negative regulation of fibroblast migration;GO:0032707,negative regulation of interleukin-23 production;GO:0048261,negative regulation of receptor-mediated endocytosis;GO:0001764,neuron migration;GO:0043312,neutrophil degranulation;GO:0031343,positive regulation of cell killing;GO:0010811,positive regulation of cell-substrate adhesion;GO:0045740,positive regulation of DNA replication;GO:0010595,positive regulation of endothelial cell migration;GO:0051894,positive regulation of focal adhesion assembly;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0010592,positive regulation of lamellipodium assembly;GO:0031116,positive regulation of microtubule polymerization;GO:0090023,positive regulation of neutrophil chemotaxis;GO:0051897,positive regulation of protein kinase B signaling;GO:0001934,positive regulation of protein phosphorylation;GO:0035025,positive regulation of Rho protein signal transduction;GO:0051496,positive regulation of stress fiber assembly;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0016601,Rac protein signal transduction;GO:0032956,regulation of actin cytoskeleton organization;GO:0030334,regulation of cell migration;GO:0008360,regulation of cell shape;GO:0008361,regulation of cell size;GO:0050690,regulation of defense response to virus by virus;GO:0010310,regulation of hydrogen peroxide metabolic process;GO:0010591,regulation of lamellipodium assembly;GO:1902622,regulation of neutrophil migration;GO:0045428,regulation of nitric oxide biosynthetic process;GO:0060263,regulation of respiratory burst;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0051492,regulation of stress fiber assembly;GO:0009611,response to wounding;GO:0097178,ruffle assembly;GO:0031529,ruffle organization;GO:0071526,semaphorin-plexin signaling pathway;GO:0003376,sphingosine-1-phosphate receptor signaling pathway;GO:0034446,substrate adhesion-dependent cell spreading;GO:0031295,T cell costimulation;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5879,path:hsa04014,Ras signaling pathway;hsa:5879,path:hsa04015,Rap1 signaling pathway;hsa:5879,path:hsa04010,MAPK signaling pathway;hsa:5879,path:hsa04310,Wnt signaling pathway;hsa:5879,path:hsa04370,VEGF signaling pathway;hsa:5879,path:hsa04071,Sphingolipid signaling pathway;hsa:5879,path:hsa04024,cAMP signaling pathway;hsa:5879,path:hsa04151,PI3K-Akt signaling pathway;hsa:5879,path:hsa04145,Phagosome;hsa:5879,path:hsa04510,Focal adhesion;hsa:5879,path:hsa04520,Adherens junction;hsa:5879,path:hsa04530,Tight junction;hsa:5879,path:hsa04810,Regulation of actin cytoskeleton;hsa:5879,path:hsa04620,Toll-like receptor signaling pathway;hsa:5879,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:5879,path:hsa04662,B cell receptor signaling pathway;hsa:5879,path:hsa04664,Fc epsilon RI signaling pathway;hsa:5879,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:5879,path:hsa04670,Leukocyte transendothelial migration;hsa:5879,path:hsa04062,Chemokine signaling pathway;hsa:5879,path:hsa04972,Pancreatic secretion;hsa:5879,path:hsa04722,Neurotrophin signaling pathway;hsa:5879,path:hsa04360,Axon guidance;hsa:5879,path:hsa04380,Osteoclast differentiation;hsa:5879,path:hsa05200,Pathways in cancer;hsa:5879,path:hsa05205,Proteoglycans in cancer;hsa:5879,path:hsa05203,Viral carcinogenesis;hsa:5879,path:hsa05231,Choline metabolism in cancer;hsa:5879,path:hsa05210,Colorectal cancer;hsa:5879,path:hsa05212,Pancreatic cancer;hsa:5879,path:hsa05211,Renal cell carcinoma;hsa:5879,path:hsa05014,Amyotrophic lateral sclerosis (ALS);hsa:5879,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:5879,path:hsa05416,Viral myocarditis;hsa:5879,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:5879,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:5879,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:5879,path:hsa05130,Pathogenic Escherichia coli infection;hsa:5879,path:hsa05132,Salmonella infection;hsa:5879,path:hsa05131,Shigellosis;hsa:5879,path:hsa05135,Yersinia infection;hsa:5879,path:hsa05100,Bacterial invasion of epithelial cells;hsa:5879,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:5879,path:hsa05163,Human cytomegalovirus infection;hsa:5879,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:5879,path:hsa05169,Epstein-Barr virus infection
VPS25_HUMAN	Q9BRG1	VPS25	Vacuolar protein-sorting-associated protein 25	0.80791668	0.832885564	0.035105451	0.029005901	0.820401122	0.032055676	0.820401122	0.032055676	25.5930064304368	0.001862	1	0.0390731742563365	0.001823	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0010008,endosome membrane;GO:0000814,ESCRT II complex;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0042803,protein homodimerization activity;GO:0047485,protein N-terminus binding;GO:0005198,structural molecule activity	GO:0016197,endosomal transport;GO:0016236,macroautophagy;GO:0036258,multivesicular body assembly;GO:0007175,negative regulation of epidermal growth factor-activated receptor activity;GO:0043328,protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0071985,multivesicular body sorting pathway;GO:0015031,protein transport	hsa:84313,path:hsa04144,Endocytosis
HV372_HUMAN	A0A0B4J1Y9	IGHV3-72	Immunoglobulin heavy variable 3-72	1.945069865	2.424990327	1.320853569	4.280680073	2.185030096	2.800766821	2.185030096	2.800766821	0.780154234767693	0.470079	0	1.28179782334678	0.470204	0	GO:0009897,external side of plasma membrane;GO:0042571,immunoglobulin complex, circulating;GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane;GO:0019814,immunoglobulin complex	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006956,complement activation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
VPS45_HUMAN	Q9NRW7	VPS45	Vacuolar protein sorting-associated protein 45	0.886277207	0.814957325	1.086917748	1.078694936	0.850617266	1.082806342	0.850617266	1.082806342	0.785567310613332	0.474285	0	1.27296539263994	0.474405	0	GO:0010008,endosome membrane;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0008021,synaptic vesicle		GO:0007596,blood coagulation;GO:0006886,intracellular protein transport;GO:0016192,vesicle-mediated transport;GO:0015031,protein transport	hsa:11311,path:hsa04144,Endocytosis
CH60_HUMAN	P10809	HSPD1	60 kDa heat shock protein, mitochondrial	38.5027144	25.94262576	49.46113684	36.40944652	32.22267008	42.93529168	32.22267008	42.93529168	0.750493797041325	0.446581	0	1.33245604952673	0.446732	0	GO:0009986,cell surface;GO:0005905,clathrin-coated pit;GO:0030135,coated vesicle;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005769,early endosome;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0046696,lipopolysaccharide receptor complex;GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0030141,secretory granule;GO:0031985,Golgi cisterna;GO:0045121,membrane raft;GO:0030061,mitochondrial crista;GO:0005782,peroxisomal matrix;GO:0005791,rough endoplasmic reticulum;GO:0042588,zymogen granule	GO:0034186,apolipoprotein A-I binding;GO:0034185,apolipoprotein binding;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0051087,chaperone binding;GO:0003688,DNA replication origin binding;GO:0003725,double-stranded RNA binding;GO:0019899,enzyme binding;GO:0008035,high-density lipoprotein particle binding;GO:0016853,isomerase activity;GO:0001530,lipopolysaccharide binding;GO:0002039,p53 binding;GO:0003723,RNA binding;GO:0003697,single-stranded DNA binding;GO:0031625,ubiquitin protein ligase binding;GO:0051082,unfolded protein binding;GO:0140030,modification-dependent protein binding;GO:0044877,protein-containing complex binding	GO:0006458,'de novo' protein folding;GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0008637,apoptotic mitochondrial changes;GO:0042113,B cell activation;GO:0042100,B cell proliferation;GO:0051702,biological process involved in interaction with symbiont;GO:0051131,chaperone-mediated protein complex assembly;GO:0048291,isotype switching to IgG isotypes;GO:0034514,mitochondrial unfolded protein response;GO:0002755,MyD88-dependent toll-like receptor signaling pathway;GO:0043066,negative regulation of apoptotic process;GO:0043065,positive regulation of apoptotic process;GO:0032727,positive regulation of interferon-alpha production;GO:0032729,positive regulation of interferon-gamma production;GO:0032733,positive regulation of interleukin-10 production;GO:0032735,positive regulation of interleukin-12 production;GO:0032755,positive regulation of interleukin-6 production;GO:0043032,positive regulation of macrophage activation;GO:0050870,positive regulation of T cell activation;GO:0002842,positive regulation of T cell mediated immune response to tumor cell;GO:0006457,protein folding;GO:0045041,protein import into mitochondrial intermembrane space;GO:0051604,protein maturation;GO:0042026,protein refolding;GO:0050821,protein stabilization;GO:0006357,regulation of transcription by RNA polymerase II;GO:0009409,response to cold;GO:0006986,response to unfolded protein;GO:0042110,T cell activation;GO:0016032,viral process;GO:0034605,cellular response to heat;GO:0098761,cellular response to interleukin-7;GO:0071866,negative regulation of apoptotic process in bone marrow cell;GO:0043524,negative regulation of neuron apoptotic process;GO:1903427,negative regulation of reactive oxygen species biosynthetic process;GO:0050729,positive regulation of inflammatory response;GO:0032760,positive regulation of tumor necrosis factor production;GO:0014823,response to activity;GO:0033198,response to ATP;GO:0042220,response to cocaine;GO:0042493,response to drug;GO:0043627,response to estrogen;GO:0051384,response to glucocorticoid;GO:0042542,response to hydrogen peroxide;GO:0001666,response to hypoxia;GO:0002931,response to ischemia;GO:0032496,response to lipopolysaccharide	hsa:3329,path:hsa03018,RNA degradation;hsa:3329,path:hsa04940,Type I diabetes mellitus;hsa:3329,path:hsa05134,Legionellosis;hsa:3329,path:hsa05152,Tuberculosis
SODM_HUMAN	P04179	SOD2	Superoxide dismutase [Mn], mitochondrial	37.50538634	109.0344559	6.328681704	0.766697175	73.26992112	3.5476894395	73.26992112	3.5476894395	20.6528565618546	0.003265	1	0.0484194521472142	0.003204	-1	GO:0070062,extracellular exosome;GO:0005759,mitochondrial matrix;GO:0042645,mitochondrial nucleoid;GO:0005739,mitochondrion	GO:0003677,DNA binding;GO:0019899,enzyme binding;GO:0042802,identical protein binding;GO:0030145,manganese ion binding;GO:0019825,oxygen binding;GO:0004784,superoxide dismutase activity;GO:0046872,metal ion binding	GO:0003069,acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure;GO:0001315,age-dependent response to reactive oxygen species;GO:0071361,cellular response to ethanol;GO:0034599,cellular response to oxidative stress;GO:0050665,hydrogen peroxide biosynthetic process;GO:0035722,interleukin-12-mediated signaling pathway;GO:0008285,negative regulation of cell population proliferation;GO:1902631,negative regulation of membrane hyperpolarization;GO:0043524,negative regulation of neuron apoptotic process;GO:1902176,negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:1904706,negative regulation of vascular associated smooth muscle cell proliferation;GO:0032364,oxygen homeostasis;GO:0030335,positive regulation of cell migration;GO:0010729,positive regulation of hydrogen peroxide biosynthetic process;GO:1905461,positive regulation of vascular associated smooth muscle cell apoptotic process;GO:1905932,positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching;GO:0051289,protein homotetramerization;GO:0008217,regulation of blood pressure;GO:0006357,regulation of transcription by RNA polymerase II;GO:0001836,release of cytochrome c from mitochondria;GO:0019430,removal of superoxide radicals;GO:0014823,response to activity;GO:0046686,response to cadmium ion;GO:0009409,response to cold;GO:0042493,response to drug;GO:0051602,response to electrical stimulus;GO:0042542,response to hydrogen peroxide;GO:0001666,response to hypoxia;GO:0035902,response to immobilization stress;GO:0035900,response to isolation stress;GO:0033591,response to L-ascorbic acid;GO:0032496,response to lipopolysaccharide;GO:0071000,response to magnetism;GO:0010042,response to manganese ion;GO:0009314,response to radiation;GO:0010269,response to selenium ion;GO:0034021,response to silicon dioxide;GO:0000303,response to superoxide;GO:0010043,response to zinc ion;GO:0006801,superoxide metabolic process	hsa:6648,path:hsa04068,FoxO signaling pathway;hsa:6648,path:hsa04146,Peroxisome;hsa:6648,path:hsa04211,Longevity regulating pathway;hsa:6648,path:hsa04213,Longevity regulating pathway - multiple species;hsa:6648,path:hsa05016,Huntington disease
THTM_HUMAN	P25325	MPST	3-mercaptopyruvate sulfurtransferase	0.785780183	1.033261486	1.752382009	1.355889084	0.9095208345	1.5541355465	0.9095208345	1.5541355465	0.585226196356098	0.303479	0	1.70874100685596	0.303765	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0043005,neuron projection;GO:0045202,synapse	GO:0016784,3-mercaptopyruvate sulfurtransferase activity;GO:0042802,identical protein binding;GO:0004792,thiosulfate sulfurtransferase activity	GO:0009440,cyanate catabolic process;GO:0070814,hydrogen sulfide biosynthetic process;GO:0001822,kidney development;GO:0001889,liver development;GO:0009636,response to toxic substance;GO:0021510,spinal cord development;GO:0000098,sulfur amino acid catabolic process;GO:0019346,transsulfuration	hsa:4357,path:hsa00920,Sulfur metabolism;hsa:4357,path:hsa00270,Cysteine and methionine metabolism;hsa:4357,path:hsa04122,Sulfur relay system
GRP75_HUMAN	P38646	HSPA9	Stress-70 protein, mitochondrial	17.05522655	14.39835662	23.57516124	14.39788047	15.726791585	18.986520855	15.726791585	18.986520855	0.828313502252754	0.496376	0	1.20727236400265	0.496318	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0140275,MIB complex;GO:0005759,mitochondrial matrix;GO:0042645,mitochondrial nucleoid;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0001401,SAM complex	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0031072,heat shock protein binding;GO:0051787,misfolded protein binding;GO:0044183,protein folding chaperone;GO:0003723,RNA binding;GO:0031625,ubiquitin protein ligase binding;GO:0051082,unfolded protein binding	GO:0034620,cellular response to unfolded protein;GO:0051085,chaperone cofactor-dependent protein refolding;GO:0030218,erythrocyte differentiation;GO:0007007,inner mitochondrial membrane organization;GO:0035722,interleukin-12-mediated signaling pathway;GO:0016226,iron-sulfur cluster assembly;GO:0043066,negative regulation of apoptotic process;GO:0045647,negative regulation of erythrocyte differentiation;GO:1902037,negative regulation of hematopoietic stem cell differentiation;GO:1903707,negative regulation of hemopoiesis;GO:0006611,protein export from nucleus;GO:0042026,protein refolding;GO:0045646,regulation of erythrocyte differentiation	hsa:3313,path:hsa03018,RNA degradation;hsa:3313,path:hsa05152,Tuberculosis
K1C17_HUMAN	Q04695	KRT17	Keratin, type I cytoskeletal 17	5.922757515	6.248476889	9.135275772	3.31003409	6.085617202	6.222654931	6.085617202	6.222654931	0.977977610759468	0.440746	0	1.02251829591828	0.440565	0	GO:0071944,cell periphery;GO:0005829,cytosol;GO:0005882,intermediate filament;GO:0045111,intermediate filament cytoskeleton	GO:0005198,structural molecule activity	GO:0070268,cornification;GO:0031069,hair follicle morphogenesis;GO:0045109,intermediate filament organization;GO:0031424,keratinization;GO:0030307,positive regulation of cell growth;GO:0051798,positive regulation of hair follicle development;GO:0045727,positive regulation of translation	hsa:3872,path:hsa04915,Estrogen signaling pathway;hsa:3872,path:hsa05150,Staphylococcus aureus infection
HEAT1_HUMAN	Q9H583	HEATR1	HEAT repeat-containing protein 1	0.235085563	0.087071811	0.333407783	0.079997096	0.161078687	0.2067024395	0.161078687	0.2067024395	0.779278112970699	0.469396	0	1.28323891477958	0.469522	0	GO:0030686,90S preribosome;GO:0001650,fibrillar center;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0032040,small-subunit processome;GO:0034455,t-UTP complex	GO:0003723,RNA binding;GO:0030515,snoRNA binding	GO:0000462,maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:2000234,positive regulation of rRNA processing;GO:0045943,positive regulation of transcription by RNA polymerase I;GO:0006364,rRNA processing	hsa:55127,path:hsa03008,Ribosome biogenesis in eukaryotes
NDUS7_HUMAN	O75251	NDUFS7	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	1.283158081	2.234334108	0.134729024	0.91232543	1.7587460945	0.523527227	1.7587460945	0.523527227	3.3594166717522	0.117180	0	0.297670726114013	0.116634	0	GO:0005759,mitochondrial matrix;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion;GO:0070469,respirasome;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0097060,synaptic membrane	GO:0051539,4 iron, 4 sulfur cluster binding;GO:0046872,metal ion binding;GO:0008137,NADH dehydrogenase (ubiquinone) activity;GO:0016655,oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0048038,quinone binding;GO:0002020,protease binding	GO:0009060,aerobic respiration;GO:0015990,electron transport coupled proton transport;GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly	hsa:374291,path:hsa00190,Oxidative phosphorylation;hsa:374291,path:hsa04723,Retrograde endocannabinoid signaling;hsa:374291,path:hsa04714,Thermogenesis;hsa:374291,path:hsa05010,Alzheimer disease;hsa:374291,path:hsa05012,Parkinson disease;hsa:374291,path:hsa05016,Huntington disease;hsa:374291,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
AL5AP_HUMAN	P20292	ALOX5AP	Arachidonate 5-lipoxygenase-activating protein	1.44716078	26.56711482	0.356237518	0.93768819	14.0071378	0.646962854	14.0071378	0.646962854	21.650605924896	0.002893	1	0.0461880837639792	0.002838	-1	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0005829,cytosol	GO:0050544,arachidonic acid binding;GO:0008047,enzyme activator activity;GO:0004602,glutathione peroxidase activity;GO:0004364,glutathione transferase activity;GO:0004464,leukotriene-C4 synthase activity;GO:0047485,protein N-terminus binding;GO:0004051,arachidonate 5-lipoxygenase activity;GO:0019899,enzyme binding;GO:0042802,identical protein binding;GO:0044877,protein-containing complex binding	GO:0071277,cellular response to calcium ion;GO:0019370,leukotriene biosynthetic process;GO:0006691,leukotriene metabolic process;GO:2001301,lipoxin biosynthetic process;GO:0019372,lipoxygenase pathway;GO:0070207,protein homotrimerization;GO:0002540,leukotriene production involved in inflammatory response;GO:0002675,positive regulation of acute inflammatory response	hsa:241,path:hsa04664,Fc epsilon RI signaling pathway
ELMO2_HUMAN	Q96JJ3	ELMO2	Engulfment and cell motility protein 2	0.091060492	0.119048335	0.157380089	0.233676141	0.1050544135	0.195528115	0.1050544135	0.195528115	0.537285461479542	0.259452	0	1.86120800150867	0.259766	0	GO:0005829,cytosol;GO:0016020,membrane;GO:0016021,integral component of membrane;GO:0005737,cytoplasm	GO:0030971,receptor tyrosine kinase binding;GO:0017124,SH3 domain binding	GO:0007015,actin filament organization;GO:0006915,apoptotic process;GO:0060326,cell chemotaxis;GO:0048870,cell motility;GO:0098609,cell-cell adhesion;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:0016477,cell migration;GO:0007010,cytoskeleton organization;GO:0006909,phagocytosis	hsa:63916,path:hsa05131,Shigellosis;hsa:63916,path:hsa05100,Bacterial invasion of epithelial cells
U2AF1_HUMAN	Q01081	U2AF1	Splicing factor U2AF 35 kDa subunit	0.100566771	0.294110135	0.154066763	0.162766429	0.197338453	0.158416596	0.197338453	0.158416596	1.24569305226076	0.362037	0	0.802765976887434	0.361695	0	GO:0015030,Cajal body;GO:0071013,catalytic step 2 spliceosome;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005681,spliceosomal complex;GO:0089701,U2AF complex	GO:0046872,metal ion binding;GO:0030628,pre-mRNA 3'-splice site binding;GO:0003723,RNA binding	GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0006405,RNA export from nucleus;GO:0008380,RNA splicing	hsa:102724594,path:hsa03040,Spliceosome;hsa:102724594,path:hsa05131,Shigellosis;hsa:7307,path:hsa03040,Spliceosome;hsa:7307,path:hsa05131,Shigellosis
PUR8_HUMAN	P30566	ADSL	Adenylosuccinate lyase	0.888618249	0.5875055	1.059734789	1.453523736	0.7380618745	1.2566292625	0.7380618745	1.2566292625	0.587334623285521	0.305402	0	1.70260693028115	0.305687	0	GO:0005829,cytosol;GO:0032991,protein-containing complex	GO:0070626,(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity;GO:0042802,identical protein binding;GO:0004018,N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity;GO:0016829,lyase activity;GO:0003824,catalytic activity	GO:0044208,'de novo' AMP biosynthetic process;GO:0006189,'de novo' IMP biosynthetic process;GO:0006167,AMP biosynthetic process;GO:0006164,purine nucleotide biosynthetic process;GO:0009168,purine ribonucleoside monophosphate biosynthetic process	hsa:158,path:hsa00230,Purine metabolism;hsa:158,path:hsa00250,Alanine, aspartate and glutamate metabolism
AMPN_HUMAN	P15144	ANPEP	Aminopeptidase N	1.184614833	7.67361974	1.58460981	2.095894882	4.4291172865	1.840252346	4.4291172865	1.840252346	2.40679888066829	0.181904	0	0.415489639800036	0.181336	0	GO:0005737,cytoplasm;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0016021,integral component of membrane;GO:0005765,lysosomal membrane;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane	GO:0004177,aminopeptidase activity;GO:0070006,metalloaminopeptidase activity;GO:0008237,metallopeptidase activity;GO:0042277,peptide binding;GO:0038023,signaling receptor activity;GO:0001618,virus receptor activity;GO:0008270,zinc ion binding	GO:0001525,angiogenesis;GO:0030154,cell differentiation;GO:0043312,neutrophil degranulation;GO:0043171,peptide catabolic process;GO:0006508,proteolysis;GO:0008217,regulation of blood pressure;GO:0007165,signal transduction	hsa:290,path:hsa00480,Glutathione metabolism;hsa:290,path:hsa04640,Hematopoietic cell lineage;hsa:290,path:hsa04614,Renin-angiotensin system
AACT_HUMAN	P01011	SERPINA3	Alpha-1-antichymotrypsin	17.60295965	26.68791299	25.77156288	96.40102383	22.14543632	61.086293355	22.14543632	61.086293355	0.362527092473968	0.106330	0	2.75841453165823	0.106635	0	GO:0035578,azurophil granule lumen;GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005634,nucleus;GO:0031093,platelet alpha granule lumen;GO:0034774,secretory granule lumen	GO:0003677,DNA binding;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0006953,acute-phase response;GO:0006954,inflammatory response;GO:0030277,maintenance of gastrointestinal epithelium;GO:0010951,negative regulation of endopeptidase activity;GO:0043312,neutrophil degranulation;GO:0002576,platelet degranulation;GO:0019216,regulation of lipid metabolic process	
PGAM5_HUMAN	Q96HS1	PGAM5	Serine/threonine-protein phosphatase PGAM5, mitochondrial	2.999296436	1.472428554	3.759187435	1.288284363	2.235862495	2.523735899	2.235862495	2.523735899	0.88593362557704	0.473782	0	1.12875273172825	0.473673	0	GO:0016021,integral component of membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion	GO:0005096,GTPase activator activity;GO:0016791,phosphatase activity;GO:0106306,protein serine phosphatase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0106307,protein threonine phosphatase activity;GO:0044877,protein-containing complex binding	GO:0016236,macroautophagy;GO:0070266,necroptotic process;GO:0120163,negative regulation of cold-induced thermogenesis	hsa:192111,path:hsa04668,TNF signaling pathway;hsa:192111,path:hsa04137,Mitophagy - animal;hsa:192111,path:hsa04217,Necroptosis
F263_HUMAN	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.136274332	0.093723461	0.361996873	0.225787833	0.1149988965	0.293892353	0.1149988965	0.293892353	0.39129598074299	0.129326	0	2.55561020100745	0.129648	0	GO:0005829,cytosol;GO:0005654,nucleoplasm	GO:0003873,6-phosphofructo-2-kinase activity;GO:0005524,ATP binding;GO:0004331,fructose-2,6-bisphosphate 2-phosphatase activity	GO:0006003,fructose 2,6-bisphosphate metabolic process;GO:0006000,fructose metabolic process;GO:0045821,positive regulation of glycolytic process;GO:0007420,brain development	hsa:5209,path:hsa00051,Fructose and mannose metabolism;hsa:5209,path:hsa04066,HIF-1 signaling pathway;hsa:5209,path:hsa04152,AMPK signaling pathway
DHCR7_HUMAN	Q9UBM7	DHCR7	7-dehydrocholesterol reductase	1.099998265	1.686727043	2.15795396	0.898860935	1.393362654	1.5284074475	1.393362654	1.5284074475	0.911643460177526	0.464192	0	1.09692006105684	0.464062	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016020,membrane;GO:0005640,nuclear outer membrane;GO:0016021,integral component of membrane	GO:0047598,7-dehydrocholesterol reductase activity;GO:0050661,NADP binding;GO:0016627,oxidoreductase activity, acting on the CH-CH group of donors;GO:0009918,sterol delta7 reductase activity;GO:0016628,oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	GO:0016132,brassinosteroid biosynthetic process;GO:0006695,cholesterol biosynthetic process;GO:0033489,cholesterol biosynthetic process via desmosterol;GO:0033490,cholesterol biosynthetic process via lathosterol;GO:0045540,regulation of cholesterol biosynthetic process;GO:0019216,regulation of lipid metabolic process;GO:0016126,sterol biosynthetic process	hsa:1717,path:hsa00100,Steroid biosynthesis
DNJB4_HUMAN	Q9UDY4	DNAJB4	DnaJ homolog subfamily B member 4	0.095384487	0.384398386	0.18760516	2.55E-05	0.2398914365	0.09381533	0.2398914365	0.09381533	2.55706009348366	0.168735	0	0.391074109892205	0.168164	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0001671,ATPase activator activity;GO:0051087,chaperone binding;GO:0051082,unfolded protein binding	GO:0051085,chaperone cofactor-dependent protein refolding;GO:0009408,response to heat;GO:0006986,response to unfolded protein	
KI13B_HUMAN	Q9NQT8	KIF13B	Kinesin-like protein KIF13B	0.232469844	0.116220738	0.305375858	0.311206951	0.174345291	0.3082914045	0.174345291	0.3082914045	0.565521089641667	0.285437	0	1.76828065003488	0.285736	0	GO:0030424,axon;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005871,kinesin complex;GO:0005874,microtubule;GO:0005902,microvillus;GO:0033270,paranode region of axon	GO:0071889,14-3-3 protein binding;GO:0005524,ATP binding;GO:1990939,ATP-dependent microtubule motor activity;GO:0016887,ATPase activity;GO:0008017,microtubule binding;GO:0003777,microtubule motor activity;GO:0019901,protein kinase binding	GO:0007018,microtubule-based movement;GO:0006605,protein targeting;GO:0050770,regulation of axonogenesis;GO:0007165,signal transduction;GO:0042110,T cell activation	
FUMH_HUMAN	P07954	FH	Fumarate hydratase, mitochondrial	7.806406221	3.00359673	7.123244217	5.503798476	5.4050014755	6.3135213465	5.4050014755	6.3135213465	0.8560993428012	0.485285	0	1.16808873690751	0.485202	0	GO:0005694,chromosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0035861,site of double-strand break;GO:0045239,tricarboxylic acid cycle enzyme complex	GO:0004333,fumarate hydratase activity;GO:0042393,histone binding	GO:0006974,cellular response to DNA damage stimulus;GO:0006281,DNA repair;GO:0006106,fumarate metabolic process;GO:0048873,homeostasis of number of cells within a tissue;GO:0006108,malate metabolic process;GO:0000415,negative regulation of histone H3-K36 methylation;GO:0120162,positive regulation of cold-induced thermogenesis;GO:2001034,positive regulation of double-strand break repair via nonhomologous end joining;GO:0000821,regulation of arginine metabolic process;GO:0006099,tricarboxylic acid cycle;GO:0000050,urea cycle	hsa:2271,path:hsa00020,Citrate cycle (TCA cycle);hsa:2271,path:hsa00620,Pyruvate metabolism;hsa:2271,path:hsa05200,Pathways in cancer;hsa:2271,path:hsa05211,Renal cell carcinoma;hsa:2271,path:hsa04934,Cushing syndrome
SH3L1_HUMAN	O75368	SH3BGRL	SH3 domain-binding glutamic acid-rich-like protein	2.096770749	6.579461318	2.15136237	2.337233859	4.3381160335	2.2442981145	4.3381160335	2.2442981145	1.93294999691539	0.234737	0	0.517343956954811	0.234203	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005634,nucleus	GO:0017124,SH3 domain binding		
PON3_HUMAN	Q15166	PON3	Serum paraoxonase/lactonase 3	0.141210315	0.188986558	0.20290806	0.61821842	0.1650984365	0.41056324	0.1650984365	0.41056324	0.402126689423047	0.138329	0	2.48677848623963	0.138656	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043231,intracellular membrane-bounded organelle	GO:0018733,3,4-dihydrocoumarin hydrolase activity;GO:0102007,acyl-L-homoserine-lactone lactonohydrolase activity;GO:0004063,aryldialkylphosphatase activity;GO:0004064,arylesterase activity;GO:0046872,metal ion binding;GO:0042803,protein homodimerization activity	GO:0019439,aromatic compound catabolic process;GO:0046395,carboxylic acid catabolic process;GO:0046226,coumarin catabolic process;GO:0019372,lipoxygenase pathway;GO:0032929,negative regulation of superoxide anion generation;GO:0010124,phenylacetate catabolic process;GO:0009636,response to toxic substance	
ARC1B_HUMAN	O15143	ARPC1B	Actin-related protein 2/3 complex subunit 1B	5.203712199	7.169220033	8.770076818	5.877910804	6.186466116	7.323993811	6.186466116	7.323993811	0.844684782052719	0.489796	0	1.18387358366969	0.489723	0	GO:0015629,actin cytoskeleton;GO:0005885,Arp2/3 protein complex;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005634,nucleus;GO:0036284,tubulobulbar complex	GO:0003779,actin binding;GO:0044877,protein-containing complex binding;GO:0005200,structural constituent of cytoskeleton	GO:0034314,Arp2/3 complex-mediated actin nucleation;GO:0048013,ephrin receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0032355,response to estradiol;GO:0043627,response to estrogen	hsa:10095,path:hsa04144,Endocytosis;hsa:10095,path:hsa04810,Regulation of actin cytoskeleton;hsa:10095,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:10095,path:hsa05130,Pathogenic Escherichia coli infection;hsa:10095,path:hsa05132,Salmonella infection;hsa:10095,path:hsa05131,Shigellosis;hsa:10095,path:hsa05100,Bacterial invasion of epithelial cells
GLYR1_HUMAN	Q49A26	GLYR1	Putative oxidoreductase GLYR1	0.145160417	0.093825562	0.271165411	0.20684239	0.1194929895	0.2390039005	0.1194929895	0.2390039005	0.499962507934049	0.225106	0	2.00014997950989	0.225434	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0000786,nucleosome	GO:0003682,chromatin binding;GO:0003677,DNA binding;GO:0042393,histone binding;GO:0035064,methylated histone binding;GO:0051287,NAD binding;GO:0050661,NADP binding;GO:0031491,nucleosome binding;GO:0016491,oxidoreductase activity	GO:0035066,positive regulation of histone acetylation;GO:0045944,positive regulation of transcription by RNA polymerase II	
S2535_HUMAN	Q3KQZ1	SLC25A35	Solute carrier family 25 member 35	0.02554891	0.035097508	0.040757025	2.55E-05	0.030323209	0.0203912625	0.030323209	0.0203912625	1.48706873838734	0.307727	0	0.672463870825809	0.307289	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane			
PABP2_HUMAN	Q86U42	PABPN1	Polyadenylate-binding protein 2	0.291002419	0.556900508	0.325510921	0.003348445	0.4239514635	0.164429683	0.4239514635	0.164429683	2.57831466779633	0.166983	0	0.387850254466688	0.166413	0	GO:0005737,cytoplasm;GO:0042405,nuclear inclusion body;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex	GO:0003723,RNA binding;GO:0070063,RNA polymerase binding	GO:0071222,cellular response to lipopolysaccharide;GO:0000165,MAPK cascade;GO:0046778,modification by virus of host mRNA processing;GO:0031124,mRNA 3'-end processing;GO:0000398,mRNA splicing, via spliceosome;GO:0006936,muscle contraction;GO:0016973,poly(A)+ mRNA export from nucleus;GO:1904247,positive regulation of polynucleotide adenylyltransferase activity;GO:0006396,RNA processing;GO:0006369,termination of RNA polymerase II transcription	hsa:8106,path:hsa03015,mRNA surveillance pathway;hsa:8106,path:hsa05164,Influenza A
ISG15_HUMAN	P05161	ISG15	Ubiquitin-like protein ISG15	1.642932905	2.679450817	0.61231339	0.639674096	2.161191861	0.625993743	2.161191861	0.625993743	3.45241767216833	0.112714	0	0.289652091652033	0.112173	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022627,cytosolic small ribosomal subunit;GO:0005576,extracellular region;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005178,integrin binding;GO:0031386,protein tag;GO:0031625,ubiquitin protein ligase binding	GO:0042742,defense response to bacterium;GO:0051607,defense response to virus;GO:0007229,integrin-mediated signaling pathway;GO:0032020,ISG15-protein conjugation;GO:0019941,modification-dependent protein catabolic process;GO:0031397,negative regulation of protein ubiquitination;GO:0032480,negative regulation of type I interferon production;GO:0060339,negative regulation of type I interferon-mediated signaling pathway;GO:0045071,negative regulation of viral genome replication;GO:0030501,positive regulation of bone mineralization;GO:0045648,positive regulation of erythrocyte differentiation;GO:0032729,positive regulation of interferon-gamma production;GO:0032733,positive regulation of interleukin-10 production;GO:0032649,regulation of interferon-gamma production;GO:0034340,response to type I interferon;GO:0009615,response to virus;GO:0019985,translesion synthesis;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process	hsa:9636,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:9636,path:hsa05169,Epstein-Barr virus infection;hsa:9636,path:hsa05165,Human papillomavirus infection
TACD2_HUMAN	P09758	TACSTD2	Tumor-associated calcium signal transducer 2	0.203454394	0.13827619	0.069051454	0.406746318	0.170865292	0.237898886	0.170865292	0.237898886	0.718226532595029	0.420168	0	1.39231837674792	0.420347	0	GO:0009925,basal plasma membrane;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0016021,integral component of membrane;GO:0016328,lateral plasma membrane;GO:0016020,membrane;GO:0005634,nucleus		GO:0090191,negative regulation of branching involved in ureteric bud morphogenesis;GO:2000146,negative regulation of cell motility;GO:0010633,negative regulation of epithelial cell migration;GO:1900028,negative regulation of ruffle assembly;GO:0051497,negative regulation of stress fiber assembly;GO:1900025,negative regulation of substrate adhesion-dependent cell spreading;GO:2000738,positive regulation of stem cell differentiation;GO:0050896,response to stimulus;GO:0007601,visual perception	
CP4FB_HUMAN	Q9HBI6	CYP4F11	Cytochrome P450 4F11	0.012179301	0.127606029	0.330887793	0.324489023	0.069892665	0.327688408	0.069892665	0.327688408	0.213290013603411	0.019847	-1	4.68845204285743	0.019972	1	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle	GO:0008391,arachidonic acid monooxygenase activity;GO:0070330,aromatase activity;GO:0005504,fatty acid binding;GO:0020037,heme binding;GO:0005506,iron ion binding;GO:0050051,leukotriene-B4 20-monooxygenase activity;GO:0102033,long-chain fatty acid omega-hydroxylase activity;GO:0016709,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0004497,monooxygenase activity;GO:0016705,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0019369,arachidonic acid metabolic process;GO:0007596,blood coagulation;GO:0006631,fatty acid metabolic process;GO:0036101,leukotriene B4 catabolic process;GO:0042361,menaquinone catabolic process;GO:0031408,oxylipin biosynthetic process;GO:0042376,phylloquinone catabolic process;GO:0042377,vitamin K catabolic process	
TRIP6_HUMAN	Q15654	TRIP6	Thyroid receptor-interacting protein 6	0.221024626	0.101995482	0.357890293	1.155618356	0.161510054	0.7567543245	0.161510054	0.7567543245	0.213424685886945	0.019893	-1	4.6854936009123	0.020019	1	GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0001725,stress fiber	GO:0005149,interleukin-1 receptor binding;GO:0019900,kinase binding;GO:0046872,metal ion binding;GO:0003723,RNA binding;GO:0046966,thyroid hormone receptor binding	GO:0043009,chordate embryonic development;GO:0048041,focal adhesion assembly;GO:0030335,positive regulation of cell migration;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:0007165,signal transduction	hsa:7205,path:hsa04621,NOD-like receptor signaling pathway
MK14_HUMAN	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.486200718	1.027021123	0.696658406	0.366923195	0.7566109205	0.5317908005	0.7566109205	0.5317908005	1.42276045352537	0.320951	0	0.702859007306649	0.320534	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0098978,glutamatergic synapse;GO:0005739,mitochondrion;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0034774,secretory granule lumen;GO:0000922,spindle pole	GO:0005524,ATP binding;GO:0019899,enzyme binding;GO:0004707,MAP kinase activity;GO:0004708,MAP kinase kinase activity;GO:0048273,mitogen-activated protein kinase p38 binding;GO:0051525,NFAT protein binding;GO:0019903,protein phosphatase binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0004672,protein kinase activity	GO:0070935,3'-UTR-mediated mRNA stabilization;GO:0000187,activation of MAPK activity;GO:0001525,angiogenesis;GO:0006915,apoptotic process;GO:0060348,bone development;GO:0001502,cartilage condensation;GO:0000902,cell morphogenesis;GO:0007166,cell surface receptor signaling pathway;GO:0071479,cellular response to ionizing radiation;GO:0071222,cellular response to lipopolysaccharide;GO:0071223,cellular response to lipoteichoic acid;GO:0071356,cellular response to tumor necrosis factor;GO:0035924,cellular response to vascular endothelial growth factor stimulus;GO:0098586,cellular response to virus;GO:0006935,chemotaxis;GO:0002062,chondrocyte differentiation;GO:0000077,DNA damage checkpoint;GO:0019395,fatty acid oxidation;GO:0006006,glucose metabolic process;GO:0035556,intracellular signal transduction;GO:0031663,lipopolysaccharide-mediated signaling pathway;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0035331,negative regulation of hippo signaling;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0043312,neutrophil degranulation;GO:0001649,osteoblast differentiation;GO:0030316,osteoclast differentiation;GO:0038066,p38MAPK cascade;GO:0018105,peptidyl-serine phosphorylation;GO:0001890,placenta development;GO:0030168,platelet activation;GO:0090336,positive regulation of brown fat cell differentiation;GO:0060045,positive regulation of cardiac muscle cell proliferation;GO:0031281,positive regulation of cyclase activity;GO:0045648,positive regulation of erythrocyte differentiation;GO:0010628,positive regulation of gene expression;GO:0046326,positive regulation of glucose import;GO:0032735,positive regulation of interleukin-12 production;GO:0051149,positive regulation of muscle cell differentiation;GO:0045663,positive regulation of myoblast differentiation;GO:1901741,positive regulation of myoblast fusion;GO:0010831,positive regulation of myotube differentiation;GO:0042307,positive regulation of protein import into nucleus;GO:2000379,positive regulation of reactive oxygen species metabolic process;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0007265,Ras protein signal transduction;GO:1900015,regulation of cytokine production involved in inflammatory response;GO:0051090,regulation of DNA-binding transcription factor activity;GO:0030278,regulation of ossification;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0099179,regulation of synaptic membrane adhesion;GO:0006357,regulation of transcription by RNA polymerase II;GO:0032495,response to muramyl dipeptide;GO:0035994,response to muscle stretch;GO:0007165,signal transduction;GO:0042770,signal transduction in response to DNA damage;GO:0007519,skeletal muscle tissue development;GO:0090400,stress-induced premature senescence;GO:0051146,striated muscle cell differentiation;GO:0007178,transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0048010,vascular endothelial growth factor receptor signaling pathway	hsa:1432,path:hsa04015,Rap1 signaling pathway;hsa:1432,path:hsa04010,MAPK signaling pathway;hsa:1432,path:hsa04370,VEGF signaling pathway;hsa:1432,path:hsa04668,TNF signaling pathway;hsa:1432,path:hsa04068,FoxO signaling pathway;hsa:1432,path:hsa04071,Sphingolipid signaling pathway;hsa:1432,path:hsa04114,Oocyte meiosis;hsa:1432,path:hsa04218,Cellular senescence;hsa:1432,path:hsa04550,Signaling pathways regulating pluripotency of stem cells;hsa:1432,path:hsa04611,Platelet activation;hsa:1432,path:hsa04620,Toll-like receptor signaling pathway;hsa:1432,path:hsa04621,NOD-like receptor signaling pathway;hsa:1432,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:1432,path:hsa04625,C-type lectin receptor signaling pathway;hsa:1432,path:hsa04660,T cell receptor signaling pathway;hsa:1432,path:hsa04658,Th1 and Th2 cell differentiation;hsa:1432,path:hsa04659,Th17 cell differentiation;hsa:1432,path:hsa04657,IL-17 signaling pathway;hsa:1432,path:hsa04664,Fc epsilon RI signaling pathway;hsa:1432,path:hsa04670,Leukocyte transendothelial migration;hsa:1432,path:hsa04912,GnRH signaling pathway;hsa:1432,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:1432,path:hsa04917,Prolactin signaling pathway;hsa:1432,path:hsa04926,Relaxin signaling pathway;hsa:1432,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:1432,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:1432,path:hsa04728,Dopaminergic synapse;hsa:1432,path:hsa04723,Retrograde endocannabinoid signaling;hsa:1432,path:hsa04722,Neurotrophin signaling pathway;hsa:1432,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:1432,path:hsa04380,Osteoclast differentiation;hsa:1432,path:hsa04714,Thermogenesis;hsa:1432,path:hsa05205,Proteoglycans in cancer;hsa:1432,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:1432,path:hsa05014,Amyotrophic lateral sclerosis (ALS);hsa:1432,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:1432,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:1432,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:1432,path:hsa05130,Pathogenic Escherichia coli infection;hsa:1432,path:hsa05132,Salmonella infection;hsa:1432,path:hsa05131,Shigellosis;hsa:1432,path:hsa05135,Yersinia infection;hsa:1432,path:hsa05133,Pertussis;hsa:1432,path:hsa05152,Tuberculosis;hsa:1432,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:1432,path:hsa05161,Hepatitis B;hsa:1432,path:hsa05163,Human cytomegalovirus infection;hsa:1432,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:1432,path:hsa05169,Epstein-Barr virus infection;hsa:1432,path:hsa05145,Toxoplasmosis;hsa:1432,path:hsa05140,Leishmaniasis;hsa:1432,path:hsa05142,Chagas disease (American trypanosomiasis);hsa:1432,path:hsa01522,Endocrine resistance
TTC38_HUMAN	Q5R3I4	TTC38	Tetratricopeptide repeat protein 38	0.209649689	0.062150638	0.247080043	0.124699834	0.1359001635	0.1858899385	0.1359001635	0.1858899385	0.731078640385908	0.430792	0	1.3678419047671	0.430960	0	GO:0070062,extracellular exosome			
TALDO_HUMAN	P37837	TALDO1	Transaldolase	18.53118353	30.65636053	26.52521172	25.13726657	24.59377203	25.831239145	24.59377203	25.831239145	0.952094163657668	0.449679	0	1.05031627980818	0.449518	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0048029,monosaccharide binding;GO:0004801,sedoheptulose-7-phosphate;GO:0003824,catalytic activity	GO:0005975,carbohydrate metabolic process;GO:0006002,fructose 6-phosphate metabolic process;GO:0019682,glyceraldehyde-3-phosphate metabolic process;GO:0035722,interleukin-12-mediated signaling pathway;GO:0006098,pentose-phosphate shunt;GO:0009052,pentose-phosphate shunt, non-oxidative branch;GO:0005999,xylulose biosynthetic process	hsa:6888,path:hsa00030,Pentose phosphate pathway
DNJA2_HUMAN	O60884	DNAJA2	DnaJ homolog subfamily A member 2	0.504694517	0.254671362	0.763395675	0.662046439	0.3796829395	0.712721057	0.3796829395	0.712721057	0.532723055914987	0.255247	0	1.87714796440044	0.255563	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane	GO:0005524,ATP binding;GO:0001671,ATPase activator activity;GO:0051087,chaperone binding;GO:0030544,Hsp70 protein binding;GO:0046872,metal ion binding;GO:0051082,unfolded protein binding	GO:0008284,positive regulation of cell population proliferation;GO:0042026,protein refolding;GO:0009408,response to heat;GO:0006457,protein folding	hsa:10294,path:hsa04141,Protein processing in endoplasmic reticulum
HLAC_HUMAN	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	2.838725484	0.999322449	3.81499724	3.503568561	1.9190239665	3.6592829005	1.9190239665	3.6592829005	0.524426238331501	0.247601	0	1.90684585725834	0.247921	0	GO:0009986,cell surface;GO:0031901,early endosome membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0000139,Golgi membrane;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0042612,MHC class I protein complex;GO:0032398,MHC class Ib protein complex;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0030667,secretory granule membrane;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0030666,endocytic vesicle membrane;GO:0001772,immunological synapse;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0042613,MHC class II protein complex;GO:0032588,trans-Golgi network membrane;GO:0030658,transport vesicle membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0010008,endosome membrane;GO:0005882,intermediate filament;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0005797,Golgi medial cisterna;GO:0042824,MHC class I peptide loading complex;GO:0035577,azurophil granule membrane;GO:0033106,cis-Golgi network membrane;GO:0005769,early endosome;GO:0031527,filopodium membrane;GO:0005771,multivesicular body	GO:0030881,beta-2-microglobulin binding;GO:0042288,MHC class I protein binding;GO:0046703,natural killer cell lectin-like receptor binding;GO:0042605,peptide antigen binding;GO:0005102,signaling receptor binding;GO:0042608,T cell receptor binding;GO:0051087,chaperone binding;GO:0046977,TAP binding;GO:0023026,MHC class II protein complex binding;GO:0032395,MHC class II receptor activity;GO:0030247,polysaccharide binding;GO:0042609,CD4 receptor binding;GO:0005200,structural constituent of cytoskeleton;GO:0042610,CD8 receptor binding;GO:0003723,RNA binding;GO:0062061,TAP complex binding;GO:0071889,14-3-3 protein binding;GO:0046978,TAP1 binding;GO:0046979,TAP2 binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:1990405,protein antigen binding;GO:0015643,toxic substance binding;GO:0008134,transcription factor binding;GO:0031625,ubiquitin protein ligase binding;GO:0046872,metal ion binding	GO:0002250,adaptive immune response;GO:0019731,antibacterial humoral response;GO:0002476,antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0002477,antigen processing and presentation of exogenous peptide antigen via MHC class Ib;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0036037,CD8-positive, alpha-beta T cell activation;GO:0050830,defense response to Gram-positive bacterium;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0002519,natural killer cell tolerance induction;GO:0045953,negative regulation of natural killer cell mediated cytotoxicity;GO:0001815,positive regulation of antibody-dependent cellular cytotoxicity;GO:2001187,positive regulation of CD8-positive, alpha-beta T cell activation;GO:2000566,positive regulation of CD8-positive, alpha-beta T cell proliferation;GO:0002639,positive regulation of immunoglobulin production;GO:0032736,positive regulation of interleukin-13 production;GO:0032753,positive regulation of interleukin-4 production;GO:0002729,positive regulation of natural killer cell cytokine production;GO:0045954,positive regulation of natural killer cell mediated cytotoxicity;GO:0002717,positive regulation of natural killer cell mediated immunity;GO:0032819,positive regulation of natural killer cell proliferation;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:0032759,positive regulation of TRAIL production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0042270,protection from natural killer cell mediated cytotoxicity;GO:0050776,regulation of immune response;GO:0002715,regulation of natural killer cell mediated immunity;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process;GO:0002486,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006952,defense response;GO:0016045,detection of bacterium;GO:0006955,immune response;GO:0043312,neutrophil degranulation;GO:2001198,regulation of dendritic cell differentiation;GO:0032655,regulation of interleukin-12 production;GO:0032675,regulation of interleukin-6 production;GO:0002667,regulation of T cell anergy;GO:0002491,antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002504,antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0050890,cognition;GO:0002469,myeloid dendritic cell antigen processing and presentation;GO:0002503,peptide antigen assembly with MHC class II protein complex;GO:2000516,positive regulation of CD4-positive, alpha-beta T cell activation;GO:0032831,positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0043382,positive regulation of memory T cell differentiation;GO:0045622,regulation of T-helper cell differentiation;GO:0050852,T cell receptor signaling pathway;GO:0002399,MHC class II protein complex assembly;GO:2001190,positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0042102,positive regulation of T cell proliferation;GO:0032729,positive regulation of interferon-gamma production;GO:0050870,positive regulation of T cell activation;GO:0008544,epidermis development;GO:0006959,humoral immune response;GO:0002437,inflammatory response to antigenic stimulus;GO:0030225,macrophage differentiation;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0032689,negative regulation of interferon-gamma production;GO:0042130,negative regulation of T cell proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0033674,positive regulation of kinase activity;GO:0043410,positive regulation of MAPK cascade;GO:0045657,positive regulation of monocyte differentiation;GO:0001934,positive regulation of protein phosphorylation;GO:0002842,positive regulation of T cell mediated immune response to tumor cell;GO:0045893,positive regulation of transcription, DNA-templated;GO:0046598,positive regulation of viral entry into host cell;GO:0051262,protein tetramerization;GO:0032653,regulation of interleukin-10 production;GO:0032673,regulation of interleukin-4 production;GO:0007165,signal transduction;GO:0042088,T-helper 1 type immune response;GO:0002587,negative regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0045580,regulation of T cell differentiation;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002485,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent;GO:0042590,antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:2000568,positive regulation of memory T cell activation;GO:0002726,positive regulation of T cell cytokine production;GO:0016567,protein ubiquitination;GO:0001913,T cell mediated cytotoxicity;GO:0002419,T cell mediated cytotoxicity directed against tumor cell target;GO:0002728,negative regulation of natural killer cell cytokine production;GO:0043322,negative regulation of natural killer cell degranulation;GO:1901215,negative regulation of neuron death;GO:0002725,negative regulation of T cell cytokine production;GO:0043323,positive regulation of natural killer cell degranulation;GO:0071346,cellular response to interferon-gamma;GO:0006968,cellular defense response;GO:0002767,immune response-inhibiting cell surface receptor signaling pathway;GO:0016525,negative regulation of angiogenesis;GO:2001199,negative regulation of dendritic cell differentiation;GO:0070317,negative regulation of G0 to G1 transition;GO:0050777,negative regulation of immune response;GO:0051898,negative regulation of protein kinase B signaling;GO:0001915,negative regulation of T cell mediated cytotoxicity;GO:0002451,peripheral B cell tolerance induction;GO:2000774,positive regulation of cellular senescence;GO:2000353,positive regulation of endothelial cell apoptotic process;GO:0032735,positive regulation of interleukin-12 production;GO:0060907,positive regulation of macrophage cytokine production;GO:0045591,positive regulation of regulatory T cell differentiation;GO:0002666,positive regulation of T cell tolerance induction;GO:0002645,positive regulation of tolerance induction;GO:0070207,protein homotrimerization;GO:0019882,antigen processing and presentation;GO:0002344,B cell affinity maturation;GO:0046635,positive regulation of alpha-beta T cell activation;GO:0002579,positive regulation of antigen processing and presentation;GO:0002827,positive regulation of T-helper 1 type immune response	hsa:3133,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3133,path:hsa04144,Endocytosis;hsa:3133,path:hsa04145,Phagosome;hsa:3133,path:hsa04218,Cellular senescence;hsa:3133,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3133,path:hsa04612,Antigen processing and presentation;hsa:3133,path:hsa05203,Viral carcinogenesis;hsa:3133,path:hsa05320,Autoimmune thyroid disease;hsa:3133,path:hsa05330,Allograft rejection;hsa:3133,path:hsa05332,Graft-versus-host disease;hsa:3133,path:hsa05416,Viral myocarditis;hsa:3133,path:hsa04940,Type I diabetes mellitus;hsa:3133,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3133,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3133,path:hsa05168,Herpes simplex virus 1 infection;hsa:3133,path:hsa05163,Human cytomegalovirus infection;hsa:3133,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3133,path:hsa05169,Epstein-Barr virus infection;hsa:3133,path:hsa05165,Human papillomavirus infection;hsa:3106,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3106,path:hsa04144,Endocytosis;hsa:3106,path:hsa04145,Phagosome;hsa:3106,path:hsa04218,Cellular senescence;hsa:3106,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3106,path:hsa04612,Antigen processing and presentation;hsa:3106,path:hsa05203,Viral carcinogenesis;hsa:3106,path:hsa05320,Autoimmune thyroid disease;hsa:3106,path:hsa05330,Allograft rejection;hsa:3106,path:hsa05332,Graft-versus-host disease;hsa:3106,path:hsa05416,Viral myocarditis;hsa:3106,path:hsa04940,Type I diabetes mellitus;hsa:3106,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3106,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3106,path:hsa05168,Herpes simplex virus 1 infection;hsa:3106,path:hsa05163,Human cytomegalovirus infection;hsa:3106,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3106,path:hsa05169,Epstein-Barr virus infection;hsa:3106,path:hsa05165,Human papillomavirus infection;hsa:3122,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3122,path:hsa04145,Phagosome;hsa:3122,path:hsa04640,Hematopoietic cell lineage;hsa:3122,path:hsa04612,Antigen processing and presentation;hsa:3122,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3122,path:hsa04659,Th17 cell differentiation;hsa:3122,path:hsa04672,Intestinal immune network for IgA production;hsa:3122,path:hsa05310,Asthma;hsa:3122,path:hsa05322,Systemic lupus erythematosus;hsa:3122,path:hsa05323,Rheumatoid arthritis;hsa:3122,path:hsa05320,Autoimmune thyroid disease;hsa:3122,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3122,path:hsa05330,Allograft rejection;hsa:3122,path:hsa05332,Graft-versus-host disease;hsa:3122,path:hsa05416,Viral myocarditis;hsa:3122,path:hsa04940,Type I diabetes mellitus;hsa:3122,path:hsa05150,Staphylococcus aureus infection;hsa:3122,path:hsa05152,Tuberculosis;hsa:3122,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3122,path:hsa05164,Influenza A;hsa:3122,path:hsa05168,Herpes simplex virus 1 infection;hsa:3122,path:hsa05169,Epstein-Barr virus infection;hsa:3122,path:hsa05145,Toxoplasmosis;hsa:3122,path:hsa05140,Leishmaniasis;hsa:3109,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3109,path:hsa04145,Phagosome;hsa:3109,path:hsa04640,Hematopoietic cell lineage;hsa:3109,path:hsa04612,Antigen processing and presentation;hsa:3109,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3109,path:hsa04659,Th17 cell differentiation;hsa:3109,path:hsa04672,Intestinal immune network for IgA production;hsa:3109,path:hsa05310,Asthma;hsa:3109,path:hsa05322,Systemic lupus erythematosus;hsa:3109,path:hsa05323,Rheumatoid arthritis;hsa:3109,path:hsa05320,Autoimmune thyroid disease;hsa:3109,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3109,path:hsa05330,Allograft rejection;hsa:3109,path:hsa05332,Graft-versus-host disease;hsa:3109,path:hsa05416,Viral myocarditis;hsa:3109,path:hsa04940,Type I diabetes mellitus;hsa:3109,path:hsa05150,Staphylococcus aureus infection;hsa:3109,path:hsa05152,Tuberculosis;hsa:3109,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3109,path:hsa05164,Influenza A;hsa:3109,path:hsa05168,Herpes simplex virus 1 infection;hsa:3109,path:hsa05169,Epstein-Barr virus infection;hsa:3109,path:hsa05145,Toxoplasmosis;hsa:3109,path:hsa05140,Leishmaniasis;hsa:3115,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3115,path:hsa04145,Phagosome;hsa:3115,path:hsa04640,Hematopoietic cell lineage;hsa:3115,path:hsa04612,Antigen processing and presentation;hsa:3115,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3115,path:hsa04659,Th17 cell differentiation;hsa:3115,path:hsa04672,Intestinal immune network for IgA production;hsa:3115,path:hsa05310,Asthma;hsa:3115,path:hsa05322,Systemic lupus erythematosus;hsa:3115,path:hsa05323,Rheumatoid arthritis;hsa:3115,path:hsa05320,Autoimmune thyroid disease;hsa:3115,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3115,path:hsa05330,Allograft rejection;hsa:3115,path:hsa05332,Graft-versus-host disease;hsa:3115,path:hsa05416,Viral myocarditis;hsa:3115,path:hsa04940,Type I diabetes mellitus;hsa:3115,path:hsa05150,Staphylococcus aureus infection;hsa:3115,path:hsa05152,Tuberculosis;hsa:3115,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3115,path:hsa05164,Influenza A;hsa:3115,path:hsa05168,Herpes simplex virus 1 infection;hsa:3115,path:hsa05169,Epstein-Barr virus infection;hsa:3115,path:hsa05145,Toxoplasmosis;hsa:3115,path:hsa05140,Leishmaniasis;hsa:3123,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3123,path:hsa04145,Phagosome;hsa:3123,path:hsa04640,Hematopoietic cell lineage;hsa:3123,path:hsa04612,Antigen processing and presentation;hsa:3123,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3123,path:hsa04659,Th17 cell differentiation;hsa:3123,path:hsa04672,Intestinal immune network for IgA production;hsa:3123,path:hsa05310,Asthma;hsa:3123,path:hsa05322,Systemic lupus erythematosus;hsa:3123,path:hsa05323,Rheumatoid arthritis;hsa:3123,path:hsa05320,Autoimmune thyroid disease;hsa:3123,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3123,path:hsa05330,Allograft rejection;hsa:3123,path:hsa05332,Graft-versus-host disease;hsa:3123,path:hsa05416,Viral myocarditis;hsa:3123,path:hsa04940,Type I diabetes mellitus;hsa:3123,path:hsa05150,Staphylococcus aureus infection;hsa:3123,path:hsa05152,Tuberculosis;hsa:3123,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3123,path:hsa05164,Influenza A;hsa:3123,path:hsa05168,Herpes simplex virus 1 infection;hsa:3123,path:hsa05169,Epstein-Barr virus infection;hsa:3123,path:hsa05145,Toxoplasmosis;hsa:3123,path:hsa05140,Leishmaniasis;hsa:3111,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3111,path:hsa04145,Phagosome;hsa:3111,path:hsa04640,Hematopoietic cell lineage;hsa:3111,path:hsa04612,Antigen processing and presentation;hsa:3111,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3111,path:hsa04659,Th17 cell differentiation;hsa:3111,path:hsa04672,Intestinal immune network for IgA production;hsa:3111,path:hsa05310,Asthma;hsa:3111,path:hsa05322,Systemic lupus erythematosus;hsa:3111,path:hsa05323,Rheumatoid arthritis;hsa:3111,path:hsa05320,Autoimmune thyroid disease;hsa:3111,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3111,path:hsa05330,Allograft rejection;hsa:3111,path:hsa05332,Graft-versus-host disease;hsa:3111,path:hsa05416,Viral myocarditis;hsa:3111,path:hsa04940,Type I diabetes mellitus;hsa:3111,path:hsa05150,Staphylococcus aureus infection;hsa:3111,path:hsa05152,Tuberculosis;hsa:3111,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3111,path:hsa05164,Influenza A;hsa:3111,path:hsa05168,Herpes simplex virus 1 infection;hsa:3111,path:hsa05169,Epstein-Barr virus infection;hsa:3111,path:hsa05145,Toxoplasmosis;hsa:3111,path:hsa05140,Leishmaniasis;hsa:3112,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3112,path:hsa04145,Phagosome;hsa:3112,path:hsa04640,Hematopoietic cell lineage;hsa:3112,path:hsa04612,Antigen processing and presentation;hsa:3112,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3112,path:hsa04659,Th17 cell differentiation;hsa:3112,path:hsa04672,Intestinal immune network for IgA production;hsa:3112,path:hsa05310,Asthma;hsa:3112,path:hsa05322,Systemic lupus erythematosus;hsa:3112,path:hsa05323,Rheumatoid arthritis;hsa:3112,path:hsa05320,Autoimmune thyroid disease;hsa:3112,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3112,path:hsa05330,Allograft rejection;hsa:3112,path:hsa05332,Graft-versus-host disease;hsa:3112,path:hsa05416,Viral myocarditis;hsa:3112,path:hsa04940,Type I diabetes mellitus;hsa:3112,path:hsa05150,Staphylococcus aureus infection;hsa:3112,path:hsa05152,Tuberculosis;hsa:3112,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3112,path:hsa05164,Influenza A;hsa:3112,path:hsa05168,Herpes simplex virus 1 infection;hsa:3112,path:hsa05169,Epstein-Barr virus infection;hsa:3112,path:hsa05145,Toxoplasmosis;hsa:3112,path:hsa05140,Leishmaniasis;hsa:3105,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3105,path:hsa04144,Endocytosis;hsa:3105,path:hsa04145,Phagosome;hsa:3105,path:hsa04218,Cellular senescence;hsa:3105,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3105,path:hsa04612,Antigen processing and presentation;hsa:3105,path:hsa05203,Viral carcinogenesis;hsa:3105,path:hsa05320,Autoimmune thyroid disease;hsa:3105,path:hsa05330,Allograft rejection;hsa:3105,path:hsa05332,Graft-versus-host disease;hsa:3105,path:hsa05416,Viral myocarditis;hsa:3105,path:hsa04940,Type I diabetes mellitus;hsa:3105,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3105,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3105,path:hsa05168,Herpes simplex virus 1 infection;hsa:3105,path:hsa05163,Human cytomegalovirus infection;hsa:3105,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3105,path:hsa05169,Epstein-Barr virus infection;hsa:3105,path:hsa05165,Human papillomavirus infection;hsa:3134,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3134,path:hsa04144,Endocytosis;hsa:3134,path:hsa04145,Phagosome;hsa:3134,path:hsa04218,Cellular senescence;hsa:3134,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3134,path:hsa04612,Antigen processing and presentation;hsa:3134,path:hsa05203,Viral carcinogenesis;hsa:3134,path:hsa05320,Autoimmune thyroid disease;hsa:3134,path:hsa05330,Allograft rejection;hsa:3134,path:hsa05332,Graft-versus-host disease;hsa:3134,path:hsa05416,Viral myocarditis;hsa:3134,path:hsa04940,Type I diabetes mellitus;hsa:3134,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3134,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3134,path:hsa05168,Herpes simplex virus 1 infection;hsa:3134,path:hsa05163,Human cytomegalovirus infection;hsa:3134,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3134,path:hsa05169,Epstein-Barr virus infection;hsa:3134,path:hsa05165,Human papillomavirus infection;hsa:3119,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3119,path:hsa04145,Phagosome;hsa:3119,path:hsa04640,Hematopoietic cell lineage;hsa:3119,path:hsa04612,Antigen processing and presentation;hsa:3119,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3119,path:hsa04659,Th17 cell differentiation;hsa:3119,path:hsa04672,Intestinal immune network for IgA production;hsa:3119,path:hsa05310,Asthma;hsa:3119,path:hsa05322,Systemic lupus erythematosus;hsa:3119,path:hsa05323,Rheumatoid arthritis;hsa:3119,path:hsa05320,Autoimmune thyroid disease;hsa:3119,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3119,path:hsa05330,Allograft rejection;hsa:3119,path:hsa05332,Graft-versus-host disease;hsa:3119,path:hsa05416,Viral myocarditis;hsa:3119,path:hsa04940,Type I diabetes mellitus;hsa:3119,path:hsa05150,Staphylococcus aureus infection;hsa:3119,path:hsa05152,Tuberculosis;hsa:3119,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3119,path:hsa05164,Influenza A;hsa:3119,path:hsa05168,Herpes simplex virus 1 infection;hsa:3119,path:hsa05169,Epstein-Barr virus infection;hsa:3119,path:hsa05145,Toxoplasmosis;hsa:3119,path:hsa05140,Leishmaniasis;hsa:3113,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3113,path:hsa04145,Phagosome;hsa:3113,path:hsa04640,Hematopoietic cell lineage;hsa:3113,path:hsa04612,Antigen processing and presentation;hsa:3113,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3113,path:hsa04659,Th17 cell differentiation;hsa:3113,path:hsa04672,Intestinal immune network for IgA production;hsa:3113,path:hsa05310,Asthma;hsa:3113,path:hsa05322,Systemic lupus erythematosus;hsa:3113,path:hsa05323,Rheumatoid arthritis;hsa:3113,path:hsa05320,Autoimmune thyroid disease;hsa:3113,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3113,path:hsa05330,Allograft rejection;hsa:3113,path:hsa05332,Graft-versus-host disease;hsa:3113,path:hsa05416,Viral myocarditis;hsa:3113,path:hsa04940,Type I diabetes mellitus;hsa:3113,path:hsa05150,Staphylococcus aureus infection;hsa:3113,path:hsa05152,Tuberculosis;hsa:3113,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3113,path:hsa05164,Influenza A;hsa:3113,path:hsa05168,Herpes simplex virus 1 infection;hsa:3113,path:hsa05169,Epstein-Barr virus infection;hsa:3113,path:hsa05145,Toxoplasmosis;hsa:3113,path:hsa05140,Leishmaniasis;hsa:3125,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3125,path:hsa04145,Phagosome;hsa:3125,path:hsa04640,Hematopoietic cell lineage;hsa:3125,path:hsa04612,Antigen processing and presentation;hsa:3125,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3125,path:hsa04659,Th17 cell differentiation;hsa:3125,path:hsa04672,Intestinal immune network for IgA production;hsa:3125,path:hsa05310,Asthma;hsa:3125,path:hsa05322,Systemic lupus erythematosus;hsa:3125,path:hsa05323,Rheumatoid arthritis;hsa:3125,path:hsa05320,Autoimmune thyroid disease;hsa:3125,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3125,path:hsa05330,Allograft rejection;hsa:3125,path:hsa05332,Graft-versus-host disease;hsa:3125,path:hsa05416,Viral myocarditis;hsa:3125,path:hsa04940,Type I diabetes mellitus;hsa:3125,path:hsa05150,Staphylococcus aureus infection;hsa:3125,path:hsa05152,Tuberculosis;hsa:3125,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3125,path:hsa05164,Influenza A;hsa:3125,path:hsa05168,Herpes simplex virus 1 infection;hsa:3125,path:hsa05169,Epstein-Barr virus infection;hsa:3125,path:hsa05145,Toxoplasmosis;hsa:3125,path:hsa05140,Leishmaniasis;hsa:3126,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3126,path:hsa04145,Phagosome;hsa:3126,path:hsa04640,Hematopoietic cell lineage;hsa:3126,path:hsa04612,Antigen processing and presentation;hsa:3126,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3126,path:hsa04659,Th17 cell differentiation;hsa:3126,path:hsa04672,Intestinal immune network for IgA production;hsa:3126,path:hsa05310,Asthma;hsa:3126,path:hsa05322,Systemic lupus erythematosus;hsa:3126,path:hsa05323,Rheumatoid arthritis;hsa:3126,path:hsa05320,Autoimmune thyroid disease;hsa:3126,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3126,path:hsa05330,Allograft rejection;hsa:3126,path:hsa05332,Graft-versus-host disease;hsa:3126,path:hsa05416,Viral myocarditis;hsa:3126,path:hsa04940,Type I diabetes mellitus;hsa:3126,path:hsa05150,Staphylococcus aureus infection;hsa:3126,path:hsa05152,Tuberculosis;hsa:3126,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3126,path:hsa05164,Influenza A;hsa:3126,path:hsa05168,Herpes simplex virus 1 infection;hsa:3126,path:hsa05169,Epstein-Barr virus infection;hsa:3126,path:hsa05145,Toxoplasmosis;hsa:3126,path:hsa05140,Leishmaniasis;hsa:3107,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3107,path:hsa04144,Endocytosis;hsa:3107,path:hsa04145,Phagosome;hsa:3107,path:hsa04218,Cellular senescence;hsa:3107,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3107,path:hsa04612,Antigen processing and presentation;hsa:3107,path:hsa05203,Viral carcinogenesis;hsa:3107,path:hsa05320,Autoimmune thyroid disease;hsa:3107,path:hsa05330,Allograft rejection;hsa:3107,path:hsa05332,Graft-versus-host disease;hsa:3107,path:hsa05416,Viral myocarditis;hsa:3107,path:hsa04940,Type I diabetes mellitus;hsa:3107,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3107,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3107,path:hsa05168,Herpes simplex virus 1 infection;hsa:3107,path:hsa05163,Human cytomegalovirus infection;hsa:3107,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3107,path:hsa05169,Epstein-Barr virus infection;hsa:3107,path:hsa05165,Human papillomavirus infection;hsa:3135,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3135,path:hsa04144,Endocytosis;hsa:3135,path:hsa04145,Phagosome;hsa:3135,path:hsa04218,Cellular senescence;hsa:3135,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3135,path:hsa04612,Antigen processing and presentation;hsa:3135,path:hsa05203,Viral carcinogenesis;hsa:3135,path:hsa05320,Autoimmune thyroid disease;hsa:3135,path:hsa05330,Allograft rejection;hsa:3135,path:hsa05332,Graft-versus-host disease;hsa:3135,path:hsa05416,Viral myocarditis;hsa:3135,path:hsa04940,Type I diabetes mellitus;hsa:3135,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3135,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3135,path:hsa05168,Herpes simplex virus 1 infection;hsa:3135,path:hsa05163,Human cytomegalovirus infection;hsa:3135,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3135,path:hsa05169,Epstein-Barr virus infection;hsa:3135,path:hsa05165,Human papillomavirus infection;hsa:3127,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3127,path:hsa04145,Phagosome;hsa:3127,path:hsa04640,Hematopoietic cell lineage;hsa:3127,path:hsa04612,Antigen processing and presentation;hsa:3127,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3127,path:hsa04659,Th17 cell differentiation;hsa:3127,path:hsa04672,Intestinal immune network for IgA production;hsa:3127,path:hsa05310,Asthma;hsa:3127,path:hsa05322,Systemic lupus erythematosus;hsa:3127,path:hsa05323,Rheumatoid arthritis;hsa:3127,path:hsa05320,Autoimmune thyroid disease;hsa:3127,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3127,path:hsa05330,Allograft rejection;hsa:3127,path:hsa05332,Graft-versus-host disease;hsa:3127,path:hsa05416,Viral myocarditis;hsa:3127,path:hsa04940,Type I diabetes mellitus;hsa:3127,path:hsa05150,Staphylococcus aureus infection;hsa:3127,path:hsa05152,Tuberculosis;hsa:3127,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3127,path:hsa05164,Influenza A;hsa:3127,path:hsa05168,Herpes simplex virus 1 infection;hsa:3127,path:hsa05169,Epstein-Barr virus infection;hsa:3127,path:hsa05145,Toxoplasmosis;hsa:3127,path:hsa05140,Leishmaniasis;hsa:3118,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3118,path:hsa04145,Phagosome;hsa:3118,path:hsa04640,Hematopoietic cell lineage;hsa:3118,path:hsa04612,Antigen processing and presentation;hsa:3118,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3118,path:hsa04659,Th17 cell differentiation;hsa:3118,path:hsa04672,Intestinal immune network for IgA production;hsa:3118,path:hsa05310,Asthma;hsa:3118,path:hsa05322,Systemic lupus erythematosus;hsa:3118,path:hsa05323,Rheumatoid arthritis;hsa:3118,path:hsa05320,Autoimmune thyroid disease;hsa:3118,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3118,path:hsa05330,Allograft rejection;hsa:3118,path:hsa05332,Graft-versus-host disease;hsa:3118,path:hsa05416,Viral myocarditis;hsa:3118,path:hsa04940,Type I diabetes mellitus;hsa:3118,path:hsa05150,Staphylococcus aureus infection;hsa:3118,path:hsa05152,Tuberculosis;hsa:3118,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3118,path:hsa05164,Influenza A;hsa:3118,path:hsa05168,Herpes simplex virus 1 infection;hsa:3118,path:hsa05169,Epstein-Barr virus infection;hsa:3118,path:hsa05145,Toxoplasmosis;hsa:3118,path:hsa05140,Leishmaniasis;hsa:3117,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3117,path:hsa04145,Phagosome;hsa:3117,path:hsa04640,Hematopoietic cell lineage;hsa:3117,path:hsa04612,Antigen processing and presentation;hsa:3117,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3117,path:hsa04659,Th17 cell differentiation;hsa:3117,path:hsa04672,Intestinal immune network for IgA production;hsa:3117,path:hsa05310,Asthma;hsa:3117,path:hsa05322,Systemic lupus erythematosus;hsa:3117,path:hsa05323,Rheumatoid arthritis;hsa:3117,path:hsa05320,Autoimmune thyroid disease;hsa:3117,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3117,path:hsa05330,Allograft rejection;hsa:3117,path:hsa05332,Graft-versus-host disease;hsa:3117,path:hsa05416,Viral myocarditis;hsa:3117,path:hsa04940,Type I diabetes mellitus;hsa:3117,path:hsa05150,Staphylococcus aureus infection;hsa:3117,path:hsa05152,Tuberculosis;hsa:3117,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3117,path:hsa05164,Influenza A;hsa:3117,path:hsa05168,Herpes simplex virus 1 infection;hsa:3117,path:hsa05169,Epstein-Barr virus infection;hsa:3117,path:hsa05145,Toxoplasmosis;hsa:3117,path:hsa05140,Leishmaniasis
RHG04_HUMAN	P98171	ARHGAP4	Rho GTPase-activating protein 4	0.150367366	0.263833751	0.322145176	0.34215719	0.2071005585	0.332151183	0.2071005585	0.332151183	0.623512933566761	0.338128	0	1.60381596942917	0.338387	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0030426,growth cone;GO:0005874,microtubule	GO:0005096,GTPase activator activity;GO:0042802,identical protein binding	GO:0007010,cytoskeleton organization;GO:0030517,negative regulation of axon extension;GO:0030336,negative regulation of cell migration;GO:0010764,negative regulation of fibroblast migration;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007266,Rho protein signal transduction;GO:0007165,signal transduction	
PLIN2_HUMAN	Q99541	PLIN2	Perilipin-2	0.243726336	0.275169342	0.667158439	0.533668233	0.259447839	0.600413336	0.259447839	0.600413336	0.432115383593012	0.164052	0	2.31419671219539	0.164387	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005576,extracellular region;GO:0005811,lipid droplet;GO:0005634,nucleus;GO:0005886,plasma membrane		GO:0019915,lipid storage;GO:0015909,long-chain fatty acid transport;GO:0010890,positive regulation of sequestering of triglyceride;GO:0019222,regulation of metabolic process;GO:0042493,response to drug;GO:0014070,response to organic cyclic compound	hsa:123,path:hsa03320,PPAR signaling pathway
PLST_HUMAN	P13797	PLS3	Plastin-3	10.44696022	15.59802469	15.75610703	17.91776537	13.022492455	16.8369362	13.022492455	16.8369362	0.773447870818683	0.464834	0	1.29291195661514	0.464964	0	GO:0005884,actin filament;GO:0032432,actin filament bundle;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005886,plasma membrane	GO:0051015,actin filament binding;GO:0005509,calcium ion binding	GO:0051017,actin filament bundle assembly;GO:0051639,actin filament network formation;GO:0060348,bone development	
RM28_HUMAN	Q13084	MRPL28	39S ribosomal protein L28, mitochondrial	0.055676652	2.55E-05	0.043898867	2.55E-05	0.027851076	0.0219621835	0.027851076	0.0219621835	1.26813784248729	0.356410	0	0.78855781011836	0.356057	0	GO:0005829,cytosol;GO:0005743,mitochondrial inner membrane;GO:0005762,mitochondrial large ribosomal subunit;GO:0005761,mitochondrial ribosome;GO:0005739,mitochondrion;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination;GO:0006412,translation	hsa:10573,path:hsa03010,Ribosome
RAB2A_HUMAN	P61019	RAB2A	Ras-related protein Rab-2A	6.726503718	14.64361629	2.077462019	6.290843909	10.685060004	4.184152964	10.685060004	4.184152964	2.55369727061441	0.169014	0	0.391589093784559	0.168444	0	GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005765,lysosomal membrane;GO:0042470,melanosome;GO:0005634,nucleus	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030,Golgi organization;GO:0043687,post-translational protein modification;GO:0015031,protein transport	hsa:5862,path:hsa04152,AMPK signaling pathway
EEA1_HUMAN	Q15075	EEA1	Early endosome antigen 1	0.583408229	1.933380008	1.019176468	0.924740824	1.2583941185	0.971958646	1.2583941185	0.971958646	1.2946992381608	0.349918	0	0.772380156352423	0.349553	0	GO:0044308,axonal spine;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0070062,extracellular exosome;GO:0019897,extrinsic component of plasma membrane;GO:0016020,membrane;GO:0055037,recycling endosome;GO:0005969,serine-pyruvate aminotransferase complex	GO:0005545,1-phosphatidylinositol binding;GO:0005516,calmodulin binding;GO:0030742,GTP-dependent protein binding;GO:0042803,protein homodimerization activity;GO:0008270,zinc ion binding	GO:0045022,early endosome to late endosome transport;GO:0006897,endocytosis;GO:0016189,synaptic vesicle to endosome fusion;GO:0006906,vesicle fusion;GO:0039694,viral RNA genome replication	hsa:8411,path:hsa04144,Endocytosis;hsa:8411,path:hsa04145,Phagosome;hsa:8411,path:hsa05152,Tuberculosis
SUCB1_HUMAN	Q9P2R7	SUCLA2	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	2.1015141	1.07324149	2.69857823	1.638112249	1.587377795	2.1683452395	1.587377795	2.1683452395	0.73206875274439	0.431604	0	1.3659919184519	0.431772	0	GO:0070062,extracellular exosome;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0042709,succinate-CoA ligase complex	GO:0005524,ATP binding;GO:0000287,magnesium ion binding;GO:0004775,succinate-CoA ligase (ADP-forming) activity;GO:0004776,succinate-CoA ligase (GDP-forming) activity;GO:0016874,ligase activity;GO:0046872,metal ion binding;GO:0003824,catalytic activity	GO:0006104,succinyl-CoA metabolic process;GO:0006781,succinyl-CoA pathway;GO:0006099,tricarboxylic acid cycle;GO:0006105,succinate metabolic process	hsa:8803,path:hsa00020,Citrate cycle (TCA cycle);hsa:8803,path:hsa00640,Propanoate metabolism
CPSF5_HUMAN	O43809	NUDT21	Cleavage and polyadenylation specificity factor subunit 5	1.255662492	1.840380506	2.248081195	3.030003911	1.548021499	2.639042553	1.548021499	2.639042553	0.586584516130764	0.304718	0	1.7047841743185	0.305003	0	GO:0034451,centriolar satellite;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005847,mRNA cleavage and polyadenylation specificity factor complex;GO:0005849,mRNA cleavage factor complex;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0042382,paraspeckles	GO:0003682,chromatin binding;GO:0042826,histone deacetylase binding;GO:0016787,hydrolase activity;GO:0042802,identical protein binding;GO:0035925,mRNA 3'-UTR AU-rich region binding;GO:0003729,mRNA binding;GO:0042803,protein homodimerization activity;GO:0003723,RNA binding	GO:0030154,cell differentiation;GO:1990120,messenger ribonucleoprotein complex assembly;GO:0031124,mRNA 3'-end processing;GO:0110104,mRNA alternative polyadenylation;GO:0006378,mRNA polyadenylation;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0031439,positive regulation of mRNA cleavage;GO:1900365,positive regulation of mRNA polyadenylation;GO:2000975,positive regulation of pro-B cell differentiation;GO:2000738,positive regulation of stem cell differentiation;GO:0010608,posttranscriptional regulation of gene expression;GO:0098789,pre-mRNA cleavage required for polyadenylation;GO:0051290,protein heterotetramerization;GO:0051262,protein tetramerization;GO:0006369,termination of RNA polymerase II transcription	hsa:11051,path:hsa03015,mRNA surveillance pathway
FHOD1_HUMAN	Q9Y613	FHOD1	FH1/FH2 domain-containing protein 1	0.057691957	0.413553113	0.300637761	1.172487144	0.235622535	0.7365624525	0.235622535	0.7365624525	0.319894849649562	0.075292	0	3.12602719642245	0.075559	0	GO:0032059,bleb;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0014704,intercalated disc;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0051015,actin filament binding;GO:0042802,identical protein binding;GO:0019904,protein domain specific binding;GO:0043621,protein self-association	GO:0051639,actin filament network formation;GO:0030866,cortical actin cytoskeleton organization;GO:0051660,establishment of centrosome localization;GO:0007097,nuclear migration;GO:0051496,positive regulation of stress fiber assembly;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0051492,regulation of stress fiber assembly	hsa:29109,path:hsa05132,Salmonella infection
2A5D_HUMAN	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.858339598	0.382653755	1.049268749	0.578229944	0.6204966765	0.8137493465	0.6204966765	0.8137493465	0.762515729405873	0.456198	0	1.31144835632331	0.456338	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000159,protein phosphatase type 2A complex	GO:0004721,phosphoprotein phosphatase activity;GO:0072542,protein phosphatase activator activity;GO:0019888,protein phosphatase regulator activity	GO:0010801,negative regulation of peptidyl-threonine phosphorylation;GO:0007399,nervous system development;GO:0035307,positive regulation of protein dephosphorylation;GO:0006470,protein dephosphorylation;GO:0031952,regulation of protein autophosphorylation;GO:0007165,signal transduction	hsa:5528,path:hsa03015,mRNA surveillance pathway;hsa:5528,path:hsa04071,Sphingolipid signaling pathway;hsa:5528,path:hsa04151,PI3K-Akt signaling pathway;hsa:5528,path:hsa04152,AMPK signaling pathway;hsa:5528,path:hsa04114,Oocyte meiosis;hsa:5528,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:5528,path:hsa04728,Dopaminergic synapse;hsa:5528,path:hsa05165,Human papillomavirus infection
IF4A3_HUMAN	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	4.77387372	9.203570131	5.566329766	35.18509994	6.9887219255	20.375714853	6.9887219255	20.375714853	0.342992723245291	0.091606	0	2.91551374775041	0.091895	0	GO:0071013,catalytic step 2 spliceosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0035145,exon-exon junction complex;GO:0098978,glutamatergic synapse;GO:0016020,membrane;GO:0043025,neuronal cell body;GO:0016607,nuclear speck;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0099524,postsynaptic cytosol;GO:0071006,U2-type catalytic step 1 spliceosome	GO:0005524,ATP binding;GO:0003729,mRNA binding;GO:0008143,poly(A) binding;GO:0043021,ribonucleoprotein complex binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0035613,RNA stem-loop binding;GO:0035368,selenocysteine insertion sequence binding;GO:0045182,translation regulator activity;GO:0016787,hydrolase activity;GO:0003676,nucleic acid binding	GO:0008306,associative learning;GO:1990416,cellular response to brain-derived neurotrophic factor stimulus;GO:0072715,cellular response to selenite ion;GO:0048701,embryonic cranial skeleton morphogenesis;GO:0035640,exploration behavior;GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0090394,negative regulation of excitatory postsynaptic potential;GO:1904570,negative regulation of selenocysteine incorporation;GO:1904574,negative regulation of selenocysteine insertion sequence binding;GO:0017148,negative regulation of translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0045727,positive regulation of translation;GO:0099578,regulation of translation at postsynapse, modulating synaptic transmission;GO:0014070,response to organic cyclic compound;GO:0006405,RNA export from nucleus;GO:0006364,rRNA processing	hsa:9775,path:hsa03040,Spliceosome;hsa:9775,path:hsa03013,RNA transport;hsa:9775,path:hsa03015,mRNA surveillance pathway
PRS6B_HUMAN	P43686	PSMC4	26S proteasome regulatory subunit 6B	2.592997304	1.738966693	2.401576778	3.492440137	2.1659819985	2.9470084575	2.1659819985	2.9470084575	0.734976512533473	0.433987	0	1.36058769626935	0.434151	0	GO:0005829,cytosol;GO:0031597,cytosolic proteasome complex;GO:0016234,inclusion body;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0022624,proteasome accessory complex;GO:0000502,proteasome complex;GO:0008540,proteasome regulatory particle, base subcomplex;GO:0045202,synapse	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0036402,proteasome-activating ATPase activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0045899,positive regulation of RNA polymerase II transcription preinitiation complex assembly;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006508,proteolysis;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5704,path:hsa03050,Proteasome;hsa:5704,path:hsa05169,Epstein-Barr virus infection
ISOC1_HUMAN	Q96CN7	ISOC1	Isochorismatase domain-containing protein 1	0.864390446	0.507138531	1.236166488	0.641461949	0.6857644885	0.9388142185	0.6857644885	0.9388142185	0.73045814069123	0.430282	0	1.36900384059476	0.430450	0	GO:0005737,cytoplasm;GO:0005777,peroxisome			
CNDP2_HUMAN	Q96KP4	CNDP2	Cytosolic non-specific dipeptidase	12.36852483	19.54170607	21.89842053	16.98703893	15.95511545	19.44272973	15.95511545	19.44272973	0.820621161306448	0.499513	0	1.21858909707858	0.499462	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm	GO:0103046,alanylglutamate dipeptidase activity;GO:0004180,carboxypeptidase activity;GO:0016805,dipeptidase activity;GO:0046872,metal ion binding;GO:0070573,metallodipeptidase activity;GO:0008233,peptidase activity;GO:0016787,hydrolase activity	GO:0006750,glutathione biosynthetic process;GO:0006508,proteolysis	hsa:55748,path:hsa00330,Arginine and proline metabolism;hsa:55748,path:hsa00340,Histidine metabolism;hsa:55748,path:hsa00410,beta-Alanine metabolism
RAB5B_HUMAN	P61020	RAB5B	Ras-related protein Rab-5B	0.413765807	7.877288243	0.184992422	0.337660779	4.145527025	0.2613266005	4.145527025	0.2613266005	15.8633947599223	0.006253	1	0.0630382093577113	0.006153	-1	GO:0098993,anchored component of synaptic vesicle membrane;GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0030139,endocytic vesicle;GO:0012505,endomembrane system;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0042470,melanosome;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0030742,GTP-dependent protein binding;GO:0003924,GTPase activity	GO:0019882,antigen processing and presentation;GO:0006897,endocytosis;GO:0007032,endosome organization;GO:0006886,intracellular protein transport;GO:0043312,neutrophil degranulation;GO:0048227,plasma membrane to endosome transport;GO:0030100,regulation of endocytosis	hsa:5869,path:hsa04014,Ras signaling pathway;hsa:5869,path:hsa04144,Endocytosis;hsa:5869,path:hsa04145,Phagosome;hsa:5869,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:5869,path:hsa05132,Salmonella infection;hsa:5869,path:hsa05152,Tuberculosis;hsa:5869,path:hsa05146,Amoebiasis
PDE12_HUMAN	Q6L8Q7	PDE12	2',5'-phosphodiesterase 12	0.201521904	0.252303713	0.475510034	0.396160003	0.2269128085	0.4358350185	0.2269128085	0.4358350185	0.520639230140246	0.244113	0	1.92071580877727	0.244434	0	GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0000175,3'-5'-exoribonuclease activity;GO:0004527,exonuclease activity;GO:0046872,metal ion binding;GO:0004535,poly(A)-specific ribonuclease activity	GO:0071359,cellular response to dsRNA;GO:0035457,cellular response to interferon-alpha;GO:0071346,cellular response to interferon-gamma;GO:0051607,defense response to virus;GO:0000958,mitochondrial mRNA catabolic process;GO:0006397,mRNA processing;GO:0060548,negative regulation of cell death;GO:0090324,negative regulation of oxidative phosphorylation;GO:0000288,nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0090305,nucleic acid phosphodiester bond hydrolysis;GO:0045070,positive regulation of viral genome replication;GO:0044528,regulation of mitochondrial mRNA stability;GO:0090503,RNA phosphodiester bond hydrolysis, exonucleolytic	
SYIC_HUMAN	P41252	IARS1	Isoleucine--tRNA ligase, cytoplasmic	3.856162483	3.17400152	5.289513959	4.16977593	3.5150820015	4.7296449445	3.5150820015	4.7296449445	0.743202088686934	0.440688	0	1.34552904953048	0.440845	0	GO:0017101,aminoacyl-tRNA synthetase multienzyme complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005654,nucleoplasm	GO:0002161,aminoacyl-tRNA editing activity;GO:0005524,ATP binding;GO:0051020,GTPase binding;GO:0004822,isoleucine-tRNA ligase activity;GO:0000049,tRNA binding	GO:0006428,isoleucyl-tRNA aminoacylation;GO:0001649,osteoblast differentiation;GO:0006418,tRNA aminoacylation for protein translation	hsa:3376,path:hsa00970,Aminoacyl-tRNA biosynthesis
APOA1_HUMAN	P02647	APOA1	Apolipoprotein A-I	43.37890728	84.97801175	51.68528284	257.396908	64.178459515	154.54109542	64.178459515	154.54109542	0.415284098644316	0.149483	0	2.40799010427915	0.149814	0	GO:0072562,blood microparticle;GO:0009986,cell surface;GO:0042627,chylomicron;GO:0062023,collagen-containing extracellular matrix;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0034365,discoidal high-density lipoprotein particle;GO:0005769,early endosome;GO:0030139,endocytic vesicle;GO:0071682,endocytic vesicle lumen;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1903561,extracellular vesicle;GO:0034364,high-density lipoprotein particle;GO:0034363,intermediate-density lipoprotein particle;GO:0034362,low-density lipoprotein particle;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0034774,secretory granule lumen;GO:0034366,spherical high-density lipoprotein particle;GO:0034361,very-low-density lipoprotein particle	GO:0001540,amyloid-beta binding;GO:0034191,apolipoprotein A-I receptor binding;GO:0034190,apolipoprotein receptor binding;GO:0045499,chemorepellent activity;GO:0015485,cholesterol binding;GO:0120020,cholesterol transfer activity;GO:0019899,enzyme binding;GO:0031072,heat shock protein binding;GO:0008035,high-density lipoprotein particle binding;GO:0070653,high-density lipoprotein particle receptor binding;GO:0042802,identical protein binding;GO:0055102,lipase inhibitor activity;GO:0031210,phosphatidylcholine binding;GO:0060228,phosphatidylcholine-sterol O-acyltransferase activator activity;GO:0005543,phospholipid binding;GO:0005102,signaling receptor binding;GO:0008289,lipid binding	GO:0030325,adrenal gland development;GO:1990000,amyloid fibril formation;GO:0031100,animal organ regeneration;GO:0043534,blood vessel endothelial cell migration;GO:0044267,cellular protein metabolic process;GO:0006695,cholesterol biosynthetic process;GO:0033344,cholesterol efflux;GO:0042632,cholesterol homeostasis;GO:0070508,cholesterol import;GO:0008203,cholesterol metabolic process;GO:0030301,cholesterol transport;GO:0034378,chylomicron assembly;GO:0034371,chylomicron remodeling;GO:0001935,endothelial cell proliferation;GO:0007186,G protein-coupled receptor signaling pathway;GO:0008211,glucocorticoid metabolic process;GO:0034380,high-density lipoprotein particle assembly;GO:0034384,high-density lipoprotein particle clearance;GO:0034375,high-density lipoprotein particle remodeling;GO:0007229,integrin-mediated signaling pathway;GO:0019915,lipid storage;GO:0006869,lipid transport;GO:0042158,lipoprotein biosynthetic process;GO:0042157,lipoprotein metabolic process;GO:0050919,negative chemotaxis;GO:0060354,negative regulation of cell adhesion molecule production;GO:0002719,negative regulation of cytokine production involved in immune response;GO:0034115,negative regulation of heterotypic cell-cell adhesion;GO:0050728,negative regulation of inflammatory response;GO:0032691,negative regulation of interleukin-1 beta production;GO:0060192,negative regulation of lipase activity;GO:0060761,negative regulation of response to cytokine stimulus;GO:0010804,negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0010903,negative regulation of very-low-density lipoprotein particle remodeling;GO:0018206,peptidyl-methionine modification;GO:0014012,peripheral nervous system axon regeneration;GO:0006656,phosphatidylcholine biosynthetic process;GO:0046470,phosphatidylcholine metabolic process;GO:0033700,phospholipid efflux;GO:0055091,phospholipid homeostasis;GO:0002576,platelet degranulation;GO:0010875,positive regulation of cholesterol efflux;GO:0010873,positive regulation of cholesterol esterification;GO:0045723,positive regulation of fatty acid biosynthetic process;GO:0051345,positive regulation of hydrolase activity;GO:0046889,positive regulation of lipid biosynthetic process;GO:0051006,positive regulation of lipoprotein lipase activity;GO:0050766,positive regulation of phagocytosis;GO:1902995,positive regulation of phospholipid efflux;GO:0035025,positive regulation of Rho protein signal transduction;GO:0051496,positive regulation of stress fiber assembly;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0010898,positive regulation of triglyceride catabolic process;GO:0043687,post-translational protein modification;GO:0018158,protein oxidation;GO:0050821,protein stabilization;GO:0006898,receptor-mediated endocytosis;GO:0032489,regulation of Cdc42 protein signal transduction;GO:0030300,regulation of intestinal cholesterol absorption;GO:0019222,regulation of metabolic process;GO:0001932,regulation of protein phosphorylation;GO:0042493,response to drug;GO:0043627,response to estrogen;GO:0007584,response to nutrient;GO:0001523,retinoid metabolic process;GO:0043691,reverse cholesterol transport;GO:0070328,triglyceride homeostasis;GO:0034372,very-low-density lipoprotein particle remodeling;GO:0051180,vitamin transport	hsa:335,path:hsa03320,PPAR signaling pathway;hsa:335,path:hsa04975,Fat digestion and absorption;hsa:335,path:hsa04979,Cholesterol metabolism;hsa:335,path:hsa04977,Vitamin digestion and absorption;hsa:335,path:hsa05143,African trypanosomiasis
RBM12_HUMAN	Q9NTZ6	RBM12	RNA-binding protein 12	0.681407948	0.571352914	0.907674618	0.841028068	0.626380431	0.874351343	0.626380431	0.874351343	0.716394428869768	0.418643	0	1.3958790851817	0.418824	0	GO:0005654,nucleoplasm;GO:1990904,ribonucleoprotein complex	GO:0003723,RNA binding;GO:0003676,nucleic acid binding	GO:0043484,regulation of RNA splicing	
FRIL_HUMAN	P02792	FTL	Ferritin light chain	39.34931015	237.7324522	147.3253322	7.102183743	138.540881175	77.2137579715	138.540881175	77.2137579715	1.79425124245521	0.254442	0	0.557335548299034	0.253929	0	GO:0044754,autolysosome;GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0008043,intracellular ferritin complex;GO:0016020,membrane	GO:0008199,ferric iron binding;GO:0008198,ferrous iron binding;GO:0042802,identical protein binding;GO:0005506,iron ion binding	GO:0006879,cellular iron ion homeostasis;GO:0006880,intracellular sequestering of iron ion;GO:0055072,iron ion homeostasis;GO:0006826,iron ion transport;GO:0043312,neutrophil degranulation;GO:0006892,post-Golgi vesicle-mediated transport	hsa:2512,path:hsa04216,Ferroptosis;hsa:2512,path:hsa04217,Necroptosis;hsa:2512,path:hsa04978,Mineral absorption
YIF1B_HUMAN	Q5BJH7	YIF1B	Protein YIF1B	0.290568834	0.881108857	0.235271873	0.169001779	0.5858388455	0.202136826	0.5858388455	0.202136826	2.89822917027499	0.143497	0	0.345038277254355	0.142931	0	GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005794,Golgi apparatus;GO:0030173,integral component of Golgi membrane;GO:0016021,integral component of membrane		GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006612,protein targeting to membrane;GO:0015031,protein transport	
RM13_HUMAN	Q9BYD1	MRPL13	39S ribosomal protein L13, mitochondrial	0.933901205	16.84497181	0.708990686	0.093895404	8.8894365075	0.401443045	8.8894365075	0.401443045	22.1437053604952	0.002729	1	0.0451595604132279	0.002676	-1	GO:0005743,mitochondrial inner membrane;GO:0005762,mitochondrial large ribosomal subunit;GO:0005761,mitochondrial ribosome;GO:0005739,mitochondrion;GO:0005840,ribosome	GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination;GO:0017148,negative regulation of translation;GO:0006412,translation	hsa:28998,path:hsa03010,Ribosome
IPO7_HUMAN	O95373	IPO7	Importin-7	1.259748348	1.00534385	2.030883512	0.373555364	1.132546099	1.202219438	1.132546099	1.202219438	0.942046071792095	0.453221	0	1.06151920797001	0.453067	0	GO:0005829,cytosol;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0005643,nuclear pore;GO:0005654,nucleoplasm;GO:0005737,cytoplasm	GO:0030695,GTPase regulator activity;GO:0042393,histone binding;GO:0046332,SMAD binding;GO:0031267,small GTPase binding;GO:0005215,transporter activity	GO:0045087,innate immune response;GO:0045736,negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0006606,protein import into nucleus;GO:0007165,signal transduction;GO:0016032,viral process;GO:0006886,intracellular protein transport	
GALT7_HUMAN	Q86SF2	GALNT7	N-acetylgalactosaminyltransferase 7	0.382814533	0.121851237	0.236204374	0.179151083	0.252332885	0.2076777285	0.252332885	0.2076777285	1.21502140274035	0.369942	0	0.823030769453613	0.369615	0	GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0030246,carbohydrate binding;GO:0046872,metal ion binding;GO:0004653,polypeptide N-acetylgalactosaminyltransferase activity	GO:0005975,carbohydrate metabolic process;GO:0016266,O-glycan processing;GO:0006493,protein O-linked glycosylation;GO:0006486,protein glycosylation	hsa:51809,path:hsa00512,Mucin type O-glycan biosynthesis;hsa:51809,path:hsa00514,Other types of O-glycan biosynthesis
AL4A1_HUMAN	P30038	ALDH4A1	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	0.165446359	0.367433077	0.683229811	1.071131202	0.266439718	0.8771805065	0.266439718	0.8771805065	0.303745598569113	0.064679	0	3.29222877536599	0.064928	0	GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0003842,1-pyrroline-5-carboxylate dehydrogenase activity;GO:0004029,aldehyde dehydrogenase (NAD+) activity;GO:0009055,electron transfer activity;GO:0042802,identical protein binding;GO:0016491,oxidoreductase activity	GO:0019470,4-hydroxyproline catabolic process;GO:0046487,glyoxylate metabolic process;GO:0006562,proline catabolic process;GO:0010133,proline catabolic process to glutamate;GO:0006560,proline metabolic process	hsa:8659,path:hsa00250,Alanine, aspartate and glutamate metabolism;hsa:8659,path:hsa00330,Arginine and proline metabolism
NIT1_HUMAN	Q86X76	NIT1	Deaminated glutathione amidase	0.576188176	0.705040547	0.539018051	0.134468132	0.6406143615	0.3367430915	0.6406143615	0.3367430915	1.90238308571209	0.238883	0	0.52565648186768	0.238353	0	GO:0005737,cytoplasm;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0110050,deaminated glutathione amidase activity	GO:0043605,cellular amide catabolic process	
STAT2_HUMAN	P52630	STAT2	Signal transducer and activator of transcription 2	0.792650861	1.019558146	1.097825621	0.507516022	0.9061045035	0.8026708215	0.9061045035	0.8026708215	1.12886189360504	0.393576	0	0.885847955064269	0.393295	0	GO:0000785,chromatin;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0005634,nucleus;GO:0005737,cytoplasm	GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0042802,identical protein binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0044389,ubiquitin-like protein ligase binding;GO:0003700,DNA-binding transcription factor activity;GO:0003677,DNA binding	GO:0019221,cytokine-mediated signaling pathway;GO:0006952,defense response;GO:0051607,defense response to virus;GO:0060339,negative regulation of type I interferon-mediated signaling pathway;GO:0007259,receptor signaling pathway via JAK-STAT;GO:0042127,regulation of cell population proliferation;GO:0090140,regulation of mitochondrial fission;GO:0001932,regulation of protein phosphorylation;GO:0006357,regulation of transcription by RNA polymerase II;GO:0043434,response to peptide hormone;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process;GO:0007165,signal transduction	hsa:6773,path:hsa04630,Jak-STAT signaling pathway;hsa:6773,path:hsa04217,Necroptosis;hsa:6773,path:hsa04621,NOD-like receptor signaling pathway;hsa:6773,path:hsa04625,C-type lectin receptor signaling pathway;hsa:6773,path:hsa04062,Chemokine signaling pathway;hsa:6773,path:hsa04380,Osteoclast differentiation;hsa:6773,path:hsa05200,Pathways in cancer;hsa:6773,path:hsa05162,Measles;hsa:6773,path:hsa05164,Influenza A;hsa:6773,path:hsa05161,Hepatitis B;hsa:6773,path:hsa05160,Hepatitis C;hsa:6773,path:hsa05168,Herpes simplex virus 1 infection;hsa:6773,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:6773,path:hsa05169,Epstein-Barr virus infection;hsa:6773,path:hsa05165,Human papillomavirus infection
COR1A_HUMAN	P31146	CORO1A	Coronin-1A	12.10522031	5.021187044	21.60287041	11.39018855	8.563203677	16.49652948	8.563203677	16.49652948	0.51909122384692	0.242688	0	1.92644366550666	0.243009	0	GO:0005884,actin filament;GO:0030424,axon;GO:0005911,cell-cell junction;GO:0030864,cortical actin cytoskeleton;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005769,early endosome;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0001772,immunological synapse;GO:0030027,lamellipodium;GO:0016020,membrane;GO:0001891,phagocytic cup;GO:0045335,phagocytic vesicle;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0005938,cell cortex;GO:0005856,cytoskeleton	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0003785,actin monomer binding;GO:0008092,cytoskeletal protein binding;GO:0032036,myosin heavy chain binding;GO:0043548,phosphatidylinositol 3-kinase binding;GO:0008022,protein C-terminus binding;GO:0042803,protein homodimerization activity;GO:0003723,RNA binding	GO:0030036,actin cytoskeleton organization;GO:0007015,actin filament organization;GO:0006816,calcium ion transport;GO:0016477,cell migration;GO:0031589,cell-substrate adhesion;GO:0071353,cellular response to interleukin-4;GO:0061502,early endosome to recycling endosome transport;GO:0048873,homeostasis of number of cells within a tissue;GO:0045087,innate immune response;GO:0030595,leukocyte chemotaxis;GO:0043320,natural killer cell degranulation;GO:0051126,negative regulation of actin nucleation;GO:0043524,negative regulation of neuron apoptotic process;GO:0031339,negative regulation of vesicle fusion;GO:0038180,nerve growth factor signaling pathway;GO:0006909,phagocytosis;GO:0001845,phagolysosome assembly;GO:0050918,positive chemotaxis;GO:0030335,positive regulation of cell migration;GO:0042102,positive regulation of T cell proliferation;GO:0032956,regulation of actin cytoskeleton organization;GO:0008360,regulation of cell shape;GO:0051279,regulation of release of sequestered calcium ion into cytosol;GO:0043029,T cell homeostasis;GO:0032796,uropod organization	hsa:11151,path:hsa04145,Phagosome;hsa:11151,path:hsa05152,Tuberculosis
PRP8_HUMAN	Q6P2Q9	PRPF8	Pre-mRNA-processing-splicing factor 8	2.778650116	2.478457396	4.524163955	2.937059238	2.628553756	3.7306115965	2.628553756	3.7306115965	0.704590571279537	0.408752	0	1.41926395379376	0.408943	0	GO:0071013,catalytic step 2 spliceosome;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0071006,U2-type catalytic step 1 spliceosome;GO:0071007,U2-type catalytic step 2 spliceosome;GO:0071005,U2-type precatalytic spliceosome;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005682,U5 snRNP;GO:0005681,spliceosomal complex	GO:0070122,isopeptidase activity;GO:0070530,K63-linked polyubiquitin modification-dependent protein binding;GO:0097157,pre-mRNA intronic binding;GO:0003723,RNA binding;GO:0030619,U1 snRNA binding;GO:0030620,U2 snRNA binding;GO:0030623,U5 snRNA binding;GO:0017070,U6 snRNA binding	GO:0071222,cellular response to lipopolysaccharide;GO:0071356,cellular response to tumor necrosis factor;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0008380,RNA splicing;GO:0000375,RNA splicing, via transesterification reactions;GO:0000244,spliceosomal tri-snRNP complex assembly	hsa:10594,path:hsa03040,Spliceosome
RM22_HUMAN	Q9NWU5	MRPL22	39S ribosomal protein L22, mitochondrial	0.186977641	0.305362455	0.030299735	0.00604732	0.246170048	0.0181735275	0.246170048	0.0181735275	13.5455292320107	0.009030	1	0.0738250963009115	0.008899	-1	GO:0015934,large ribosomal subunit;GO:0005743,mitochondrial inner membrane;GO:0005762,mitochondrial large ribosomal subunit;GO:0005739,mitochondrion	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination;GO:0042255,ribosome assembly;GO:0006412,translation	hsa:29093,path:hsa03010,Ribosome
DCD_HUMAN	P81605	DCD	Dermcidin	7.247225644	7.702188867	4.365714239	47.12386737	7.4747072555	25.7447908045	7.4747072555	25.7447908045	0.290338628589418	0.056412	0	3.44425405898761	0.056645	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0008233,peptidase activity;GO:0003723,RNA binding	GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0019730,antimicrobial humoral response;GO:0042742,defense response to bacterium;GO:0050832,defense response to fungus;GO:0050829,defense response to Gram-negative bacterium;GO:0050830,defense response to Gram-positive bacterium;GO:0051873,killing by host of symbiont cells;GO:0031640,killing of cells of other organism	
PGTA_HUMAN	Q92696	RABGGTA	Geranylgeranyl transferase type-2 subunit alpha	0.907685587	0.823790823	1.043870287	0.765876367	0.865738205	0.904873327	0.865738205	0.904873327	0.956750717661501	0.448052	0	1.04520433749369	0.447887	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0005968,Rab-protein geranylgeranyltransferase complex	GO:0004663,Rab geranylgeranyltransferase activity;GO:0031267,small GTPase binding;GO:0008270,zinc ion binding	GO:0006464,cellular protein modification process;GO:0043687,post-translational protein modification;GO:0018344,protein geranylgeranylation;GO:0042981,regulation of apoptotic process;GO:0007601,visual perception	
RFC2_HUMAN	P35250	RFC2	Replication factor C subunit 2	0.210224186	0.112525097	0.266272152	0.364615511	0.1613746415	0.3154438315	0.1613746415	0.3154438315	0.511579639178964	0.235775	0	1.95472986689795	0.236100	0	GO:0031390,Ctf18 RFC-like complex;GO:0005663,DNA replication factor C complex;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0003677,DNA binding;GO:0019899,enzyme binding	GO:0006287,base-excision repair, gap-filling;GO:0042769,DNA damage response, detection of DNA damage;GO:0032508,DNA duplex unwinding;GO:0006281,DNA repair;GO:0006260,DNA replication;GO:0006261,DNA-dependent DNA replication;GO:0070987,error-free translesion synthesis;GO:0042276,error-prone translesion synthesis;GO:0006297,nucleotide-excision repair, DNA gap filling;GO:0033683,nucleotide-excision repair, DNA incision;GO:0006296,nucleotide-excision repair, DNA incision, 5'-to lesion;GO:1900264,positive regulation of DNA-directed DNA polymerase activity;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0032201,telomere maintenance via semi-conservative replication;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0019985,translesion synthesis	hsa:5982,path:hsa03030,DNA replication;hsa:5982,path:hsa03420,Nucleotide excision repair;hsa:5982,path:hsa03430,Mismatch repair
SAMD9_HUMAN	Q5K651	SAMD9	Sterile alpha motif domain-containing protein 9	0.023054771	0.038414307	0.050244836	2.55E-05	0.030734539	0.025135168	0.030734539	0.025135168	1.22277038291528	0.367921	0	0.817815032136971	0.367590	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle		GO:0034058,endosomal vesicle fusion	
ADA_HUMAN	P00813	ADA	Adenosine deaminase	0.122771059	0.027557593	0.177547999	0.308960591	0.075164326	0.243254295	0.075164326	0.243254295	0.308994856596468	0.068053	0	3.23629982393509	0.068308	0	GO:0030054,cell junction;GO:0009986,cell surface;GO:0060205,cytoplasmic vesicle lumen;GO:0005829,cytosol;GO:0032839,dendrite cytoplasm;GO:0009897,external side of plasma membrane;GO:0005615,extracellular space;GO:0005764,lysosome;GO:0016020,membrane;GO:0043025,neuronal cell body;GO:0005886,plasma membrane	GO:0004000,adenosine deaminase activity;GO:0001883,purine nucleoside binding;GO:0008270,zinc ion binding;GO:0019239,deaminase activity	GO:0006154,adenosine catabolic process;GO:0007568,aging;GO:0006196,AMP catabolic process;GO:0007155,cell adhesion;GO:0046059,dAMP catabolic process;GO:0046061,dATP catabolic process;GO:0006157,deoxyadenosine catabolic process;GO:0048566,embryonic digestive tract development;GO:0002314,germinal center B cell differentiation;GO:0001821,histamine secretion;GO:0043103,hypoxanthine salvage;GO:0046103,inosine biosynthetic process;GO:0001889,liver development;GO:0048286,lung alveolus development;GO:0060169,negative regulation of adenosine receptor signaling pathway;GO:0042323,negative regulation of circadian sleep/wake cycle, non-REM sleep;GO:0050728,negative regulation of inflammatory response;GO:0002686,negative regulation of leukocyte migration;GO:0002906,negative regulation of mature B cell apoptotic process;GO:0070256,negative regulation of mucus secretion;GO:0060407,negative regulation of penile erection;GO:0070244,negative regulation of thymocyte apoptotic process;GO:0048541,Peyer's patch development;GO:0001890,placenta development;GO:0046638,positive regulation of alpha-beta T cell differentiation;GO:0030890,positive regulation of B cell proliferation;GO:0050850,positive regulation of calcium-mediated signaling;GO:0002636,positive regulation of germinal center formation;GO:0010460,positive regulation of heart rate;GO:0045987,positive regulation of smooth muscle contraction;GO:0033089,positive regulation of T cell differentiation in thymus;GO:0050862,positive regulation of T cell receptor signaling pathway;GO:0032261,purine nucleotide salvage;GO:0009168,purine ribonucleoside monophosphate biosynthetic process;GO:0043101,purine-containing compound salvage;GO:0033632,regulation of cell-cell adhesion mediated by integrin;GO:0042493,response to drug;GO:0042542,response to hydrogen peroxide;GO:0001666,response to hypoxia;GO:0043278,response to morphine;GO:0033197,response to vitamin E;GO:0042110,T cell activation;GO:0001829,trophectodermal cell differentiation;GO:0046111,xanthine biosynthetic process	hsa:100,path:hsa00230,Purine metabolism;hsa:100,path:hsa05340,Primary immunodeficiency
RM19_HUMAN	P49406	MRPL19	39S ribosomal protein L19, mitochondrial	0.36742609	0.139158141	0.217227102	0.158241414	0.2532921155	0.187734258	0.2532921155	0.187734258	1.34920561754904	0.337133	0	0.741176872518955	0.336745	0	GO:0005743,mitochondrial inner membrane;GO:0005762,mitochondrial large ribosomal subunit;GO:0005739,mitochondrion;GO:0031965,nuclear membrane;GO:0005634,nucleus;GO:0005840,ribosome	GO:0003735,structural constituent of ribosome	GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination;GO:0006412,translation	hsa:9801,path:hsa03010,Ribosome
RAP1A_HUMAN	P62834	RAP1A	Ras-related protein Rap-1A	0.165782644	0.615002625	0.052666904	0.055827014	0.3903926345	0.054246959	0.3903926345	0.054246959	7.19658100097371	0.033526	1	0.138954873135548	0.033213	-1	GO:0030054,cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005769,early endosome;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0032045,guanyl-nucleotide exchange factor complex;GO:0005770,late endosome;GO:0043005,neuron projection;GO:0048471,perinuclear region of cytoplasm;GO:0045335,phagocytic vesicle;GO:0005886,plasma membrane;GO:0035579,specific granule membrane;GO:0016020,membrane	GO:0003925,G protein activity;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0005085,guanyl-nucleotide exchange factor activity;GO:0044877,protein-containing complex binding;GO:0031267,small GTPase binding	GO:0000186,activation of MAPKK activity;GO:0002250,adaptive immune response;GO:0071320,cellular response to cAMP;GO:0035690,cellular response to drug;GO:1990090,cellular response to nerve growth factor stimulus;GO:0061028,establishment of endothelial barrier;GO:0097421,liver regeneration;GO:0032966,negative regulation of collagen biosynthetic process;GO:2000301,negative regulation of synaptic vesicle exocytosis;GO:0038180,nerve growth factor signaling pathway;GO:0007399,nervous system development;GO:0043312,neutrophil degranulation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:1905451,positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0046326,positive regulation of glucose import;GO:0043547,positive regulation of GTPase activity;GO:0010976,positive regulation of neuron projection development;GO:0045860,positive regulation of protein kinase activity;GO:2001214,positive regulation of vasculogenesis;GO:0072659,protein localization to plasma membrane;GO:0032486,Rap protein signal transduction;GO:1901888,regulation of cell junction assembly;GO:0050796,regulation of insulin secretion;GO:0098696,regulation of neurotransmitter receptor localization to postsynaptic specialization membrane;GO:0097327,response to antineoplastic agent;GO:0009743,response to carbohydrate;GO:0007165,signal transduction	hsa:5906,path:hsa04014,Ras signaling pathway;hsa:5906,path:hsa04015,Rap1 signaling pathway;hsa:5906,path:hsa04010,MAPK signaling pathway;hsa:5906,path:hsa04024,cAMP signaling pathway;hsa:5906,path:hsa04510,Focal adhesion;hsa:5906,path:hsa04530,Tight junction;hsa:5906,path:hsa04611,Platelet activation;hsa:5906,path:hsa04670,Leukocyte transendothelial migration;hsa:5906,path:hsa04062,Chemokine signaling pathway;hsa:5906,path:hsa04972,Pancreatic secretion;hsa:5906,path:hsa04720,Long-term potentiation;hsa:5906,path:hsa04722,Neurotrophin signaling pathway;hsa:5906,path:hsa05211,Renal cell carcinoma;hsa:5906,path:hsa04934,Cushing syndrome
ILEU_HUMAN	P30740	SERPINB1	Leukocyte elastase inhibitor	19.97240266	50.15024842	31.89644986	36.78054701	35.06132554	34.338498435	35.06132554	34.338498435	1.02105004988405	0.426455	0	0.979383919636029	0.426243	0	GO:0062023,collagen-containing extracellular matrix;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0016020,membrane;GO:0034774,secretory granule lumen	GO:0030414,peptidase inhibitor activity;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0010951,negative regulation of endopeptidase activity;GO:0032691,negative regulation of interleukin-1 beta production;GO:0043312,neutrophil degranulation;GO:0044342,type B pancreatic cell proliferation	
CFAH_HUMAN	P08603	CFH	Complement factor H	3.469362734	3.263145904	3.825803844	21.48267984	3.366254319	12.654241842	3.366254319	12.654241842	0.266017858756836	0.042778	-1	3.75914611399864	0.042979	1	GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0043395,heparan sulfate proteoglycan binding;GO:0008201,heparin binding;GO:0042802,identical protein binding	GO:0006956,complement activation;GO:0006957,complement activation, alternative pathway;GO:0030449,regulation of complement activation;GO:1903659,regulation of complement-dependent cytotoxicity;GO:0016032,viral process	hsa:3075,path:hsa04610,Complement and coagulation cascades;hsa:3075,path:hsa05150,Staphylococcus aureus infection
PPAC_HUMAN	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	3.820959175	6.145270457	0.521386215	0.782083459	4.983114816	0.651734837	4.983114816	0.651734837	7.64592366880029	0.029892	1	0.13078864546877	0.029600	-1	GO:0005737,cytoplasm;GO:0009898,cytoplasmic side of plasma membrane;GO:0070062,extracellular exosome	GO:0003993,acid phosphatase activity;GO:0004726,non-membrane spanning protein tyrosine phosphatase activity;GO:0004725,protein tyrosine phosphatase activity		hsa:52,path:hsa00730,Thiamine metabolism;hsa:52,path:hsa00740,Riboflavin metabolism;hsa:52,path:hsa04520,Adherens junction
SYDC_HUMAN	P14868	DARS1	Aspartate--tRNA ligase, cytoplasmic	12.43933446	6.889178983	11.95003409	16.40962643	9.6642567215	14.17983026	9.6642567215	14.17983026	0.681549535100006	0.389138	0	1.46724478339387	0.389349	0	GO:0017101,aminoacyl-tRNA synthetase multienzyme complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0045202,synapse	GO:0004046,aminoacylase activity;GO:0004815,aspartate-tRNA ligase activity;GO:0005524,ATP binding;GO:0003723,RNA binding;GO:0003676,nucleic acid binding	GO:0006422,aspartyl-tRNA aminoacylation;GO:0065003,protein-containing complex assembly;GO:0006412,translation;GO:0006418,tRNA aminoacylation for protein translation	hsa:1615,path:hsa00970,Aminoacyl-tRNA biosynthesis
PPA5_HUMAN	P13686	ACP5	Tartrate-resistant acid phosphatase type 5	0.324311258	0.443453708	0.762264648	0.924569625	0.383882483	0.8434171365	0.383882483	0.8434171365	0.455151391152698	0.184442	0	2.19707117112713	0.184778	0	GO:0005829,cytosol;GO:0016021,integral component of membrane;GO:0005764,lysosome	GO:0003993,acid phosphatase activity;GO:0008199,ferric iron binding;GO:0008198,ferrous iron binding;GO:0016787,hydrolase activity	GO:0045453,bone resorption;GO:0001503,ossification;GO:0006771,riboflavin metabolic process	hsa:54,path:hsa00740,Riboflavin metabolism;hsa:54,path:hsa04142,Lysosome;hsa:54,path:hsa04380,Osteoclast differentiation;hsa:54,path:hsa05323,Rheumatoid arthritis
A1AG1_HUMAN	P02763	ORM1	Alpha-1-acid glycoprotein 1	4.772683908	5.637030651	12.42537117	25.60954412	5.2048572795	19.017457645	5.2048572795	19.017457645	0.273688385517106	0.046881	-1	3.65379041609896	0.047092	1	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0031093,platelet alpha granule lumen;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen		GO:0006953,acute-phase response;GO:0006954,inflammatory response;GO:0032715,negative regulation of interleukin-6 production;GO:0032720,negative regulation of tumor necrosis factor production;GO:0043312,neutrophil degranulation;GO:0002576,platelet degranulation;GO:0032731,positive regulation of interleukin-1 beta production;GO:0032732,positive regulation of interleukin-1 production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0002682,regulation of immune system process	
AMPB_HUMAN	Q9H4A4	RNPEP	Aminopeptidase B	2.315290964	2.918693542	3.863668833	4.05163852	2.616992253	3.9576536765	2.616992253	3.9576536765	0.661248423160252	0.371539	0	1.51229094085515	0.371768	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane	GO:0004177,aminopeptidase activity;GO:0004301,epoxide hydrolase activity;GO:0070006,metalloaminopeptidase activity;GO:0008235,metalloexopeptidase activity;GO:0008270,zinc ion binding;GO:0008237,metallopeptidase activity	GO:0006508,proteolysis	
PP1B_HUMAN	P62140	PPP1CB	Serine/threonine-protein phosphatase PP1-beta catalytic subunit	1.089631064	0.678954109	1.150703507	1.493864454	0.8842925865	1.3222839805	0.8842925865	1.3222839805	0.668761476007309	0.378085	0	1.49530144285564	0.378307	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0042587,glycogen granule;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0000164,protein phosphatase type 1 complex;GO:0072357,PTW/PP1 phosphatase complex	GO:0046872,metal ion binding;GO:0017018,myosin phosphatase activity;GO:0050115,myosin-light-chain-phosphatase activity;GO:0016791,phosphatase activity;GO:0019901,protein kinase binding;GO:0106306,protein serine phosphatase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0106307,protein threonine phosphatase activity;GO:0016787,hydrolase activity	GO:0051301,cell division;GO:0032922,circadian regulation of gene expression;GO:0043153,entrainment of circadian clock by photoperiod;GO:0000086,G2/M transition of mitotic cell cycle;GO:0005977,glycogen metabolic process;GO:0000165,MAPK cascade;GO:0006470,protein dephosphorylation;GO:0030155,regulation of cell adhesion;GO:0042752,regulation of circadian rhythm;GO:0005979,regulation of glycogen biosynthetic process;GO:0005981,regulation of glycogen catabolic process	hsa:5500,path:hsa03015,mRNA surveillance pathway;hsa:5500,path:hsa04390,Hippo signaling pathway;hsa:5500,path:hsa04024,cAMP signaling pathway;hsa:5500,path:hsa04022,cGMP-PKG signaling pathway;hsa:5500,path:hsa04114,Oocyte meiosis;hsa:5500,path:hsa04218,Cellular senescence;hsa:5500,path:hsa04510,Focal adhesion;hsa:5500,path:hsa04810,Regulation of actin cytoskeleton;hsa:5500,path:hsa04611,Platelet activation;hsa:5500,path:hsa04910,Insulin signaling pathway;hsa:5500,path:hsa04921,Oxytocin signaling pathway;hsa:5500,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:5500,path:hsa04270,Vascular smooth muscle contraction;hsa:5500,path:hsa04728,Dopaminergic synapse;hsa:5500,path:hsa04720,Long-term potentiation;hsa:5500,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:5500,path:hsa05205,Proteoglycans in cancer;hsa:5500,path:hsa05031,Amphetamine addiction;hsa:5500,path:hsa05034,Alcoholism;hsa:5500,path:hsa04931,Insulin resistance;hsa:5500,path:hsa05168,Herpes simplex virus 1 infection
KYNU_HUMAN	Q16719	KYNU	Kynureninase	0.438055328	1.42471185	0.860228433	0.361214515	0.931383589	0.610721474	0.931383589	0.610721474	1.52505459305333	0.300291	0	0.655714231185579	0.299841	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0061981,3-hydroxykynureninase activity;GO:0030429,kynureninase activity;GO:0042803,protein homodimerization activity;GO:0030170,pyridoxal phosphate binding;GO:0003824,catalytic activity	GO:0034354,'de novo' NAD biosynthetic process from tryptophan;GO:0007568,aging;GO:0043420,anthranilate metabolic process;GO:0097053,L-kynurenine catabolic process;GO:0009435,NAD biosynthetic process;GO:0019805,quinolinate biosynthetic process;GO:0034341,response to interferon-gamma;GO:0034516,response to vitamin B6;GO:0006569,tryptophan catabolic process;GO:0019442,tryptophan catabolic process to acetyl-CoA;GO:0019441,tryptophan catabolic process to kynurenine	hsa:8942,path:hsa00380,Tryptophan metabolism
CD14_HUMAN	P08571	CD14	Monocyte differentiation antigen CD14	0.684897499	0.853338845	2.136201158	2.920631433	0.769118172	2.5284162955	0.769118172	2.5284162955	0.304189691139411	0.064962	0	3.28742238520403	0.065211	0	GO:0031362,anchored component of external side of plasma membrane;GO:0010008,endosome membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005794,Golgi apparatus;GO:0046696,lipopolysaccharide receptor complex;GO:0045121,membrane raft;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane	GO:0071723,lipopeptide binding;GO:0001530,lipopolysaccharide binding;GO:0070891,lipoteichoic acid binding;GO:0001847,opsonin receptor activity;GO:0016019,peptidoglycan immune receptor activity	GO:0006915,apoptotic process;GO:0097190,apoptotic signaling pathway;GO:0007166,cell surface receptor signaling pathway;GO:0071726,cellular response to diacyl bacterial lipopeptide;GO:0071222,cellular response to lipopolysaccharide;GO:0071223,cellular response to lipoteichoic acid;GO:0071219,cellular response to molecule of bacterial origin;GO:0071727,cellular response to triacyl bacterial lipopeptide;GO:0007249,I-kappaB kinase/NF-kappaB signaling;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0031663,lipopolysaccharide-mediated signaling pathway;GO:0002755,MyD88-dependent toll-like receptor signaling pathway;GO:0002756,MyD88-independent toll-like receptor signaling pathway;GO:0070266,necroptotic process;GO:0034128,negative regulation of MyD88-independent toll-like receptor signaling pathway;GO:0043312,neutrophil degranulation;GO:0006909,phagocytosis;GO:0045807,positive regulation of endocytosis;GO:0032729,positive regulation of interferon-gamma production;GO:0032757,positive regulation of interleukin-8 production;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:0032760,positive regulation of tumor necrosis factor production;GO:0032481,positive regulation of type I interferon production;GO:0006898,receptor-mediated endocytosis;GO:0051602,response to electrical stimulus;GO:0045471,response to ethanol;GO:0009408,response to heat;GO:0032026,response to magnesium ion;GO:0034612,response to tumor necrosis factor;GO:0034142,toll-like receptor 4 signaling pathway;GO:0002224,toll-like receptor signaling pathway;GO:0038123,toll-like receptor TLR1;GO:0038124,toll-like receptor TLR6;GO:0035666,TRIF-dependent toll-like receptor signaling pathway	hsa:929,path:hsa04010,MAPK signaling pathway;hsa:929,path:hsa04064,NF-kappa B signaling pathway;hsa:929,path:hsa04145,Phagosome;hsa:929,path:hsa04640,Hematopoietic cell lineage;hsa:929,path:hsa04620,Toll-like receptor signaling pathway;hsa:929,path:hsa05202,Transcriptional misregulation in cancer;hsa:929,path:hsa05221,Acute myeloid leukemia;hsa:929,path:hsa05132,Salmonella infection;hsa:929,path:hsa05131,Shigellosis;hsa:929,path:hsa05133,Pertussis;hsa:929,path:hsa05134,Legionellosis;hsa:929,path:hsa05152,Tuberculosis;hsa:929,path:hsa05146,Amoebiasis
TT39B_HUMAN	Q5VTQ0	TTC39B	Tetratricopeptide repeat protein 39B	0.059476182	0.09810106	0.089228287	0.117595184	0.078788621	0.1034117355	0.078788621	0.1034117355	0.761892454652789	0.455702	0	1.312521201507	0.455843	0			GO:0042632,cholesterol homeostasis;GO:0006629,lipid metabolic process;GO:0010887,negative regulation of cholesterol storage;GO:0010874,regulation of cholesterol efflux;GO:0090181,regulation of cholesterol metabolic process	
GNA13_HUMAN	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.883470718	0.631422633	0.696912983	2.028092108	0.7574466755	1.3625025455	0.7574466755	1.3625025455	0.55592312689738	0.276616	0	1.79880985628539	0.276920	0	GO:0031526,brush border membrane;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005834,heterotrimeric G-protein complex;GO:0042470,melanosome;GO:0016020,membrane;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0031752,D5 dopamine receptor binding;GO:0001664,G protein-coupled receptor binding;GO:0031683,G-protein beta/gamma-subunit complex binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0046872,metal ion binding	GO:0031584,activation of phospholipase D activity;GO:0007189,adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007188,adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007186,G protein-coupled receptor signaling pathway;GO:1904753,negative regulation of vascular associated smooth muscle cell migration;GO:1904706,negative regulation of vascular associated smooth muscle cell proliferation;GO:0030168,platelet activation;GO:0043065,positive regulation of apoptotic process;GO:0007204,positive regulation of cytosolic calcium ion concentration;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007266,Rho protein signal transduction;GO:0007165,signal transduction	hsa:10672,path:hsa04371,Apelin signaling pathway;hsa:10672,path:hsa04072,Phospholipase D signaling pathway;hsa:10672,path:hsa04071,Sphingolipid signaling pathway;hsa:10672,path:hsa04022,cGMP-PKG signaling pathway;hsa:10672,path:hsa04810,Regulation of actin cytoskeleton;hsa:10672,path:hsa04611,Platelet activation;hsa:10672,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:10672,path:hsa04270,Vascular smooth muscle contraction;hsa:10672,path:hsa04730,Long-term depression;hsa:10672,path:hsa05200,Pathways in cancer;hsa:10672,path:hsa05130,Pathogenic Escherichia coli infection;hsa:10672,path:hsa05163,Human cytomegalovirus infection
EDC4_HUMAN	Q6P2E9	EDC4	Enhancer of mRNA-decapping protein 4	1.714813288	1.790783241	2.1602687	3.936160757	1.7527982645	3.0482147285	1.7527982645	3.0482147285	0.575024537514303	0.294152	0	1.73905622240534	0.294444	0	GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body		GO:0031087,deadenylation-independent decapping of nuclear-transcribed mRNA;GO:0043928,exonucleolytic catabolism of deadenylated mRNA	hsa:23644,path:hsa03018,RNA degradation
NU153_HUMAN	P49790	NUP153	Nuclear pore complex protein Nup153	0.563017038	0.370342807	0.442511351	0.678281641	0.4666799225	0.560396496	0.4666799225	0.560396496	0.832767381364926	0.494573	0	1.20081552469187	0.494511	0	GO:0005829,cytosol;GO:0043657,host cell;GO:0016020,membrane;GO:0042405,nuclear inclusion body;GO:0031965,nuclear membrane;GO:0034399,nuclear periphery;GO:0005643,nuclear pore;GO:0044615,nuclear pore nuclear basket;GO:0005730,nucleolus;GO:0005654,nucleoplasm	GO:0003677,DNA binding;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0008139,nuclear localization sequence binding;GO:0043495,protein-membrane adaptor activity;GO:0017056,structural constituent of nuclear pore	GO:0075733,intracellular transport of virus;GO:0006406,mRNA export from nucleus;GO:0046832,negative regulation of RNA export from nucleus;GO:0051292,nuclear pore complex assembly;GO:0006606,protein import into nucleus;GO:0016925,protein sumoylation;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0006405,RNA export from nucleus;GO:0006409,tRNA export from nucleus;GO:0046718,viral entry into host cell;GO:0019058,viral life cycle;GO:0075732,viral penetration into host nucleus;GO:0016032,viral process;GO:0019083,viral transcription	hsa:9972,path:hsa03013,RNA transport
STRP1_HUMAN	Q5VSL9	STRIP1	Striatin-interacting protein 1	0.127560453	0.12452305	0.126866157	0.140189218	0.1260417515	0.1335276875	0.1260417515	0.1335276875	0.943937200290389	0.452551	0	1.05939251010805	0.452396	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0019901,protein kinase binding;GO:0031267,small GTPase binding	GO:0030866,cortical actin cytoskeleton organization;GO:0007010,cytoskeleton organization;GO:0022604,regulation of cell morphogenesis	
ATPO_HUMAN	P48047	ATP5PO	ATP synthase subunit O, mitochondrial	6.606872515	19.14724996	1.874186996	1.514865971	12.8770612375	1.6945264835	12.8770612375	1.6945264835	7.59920919672071	0.030244	1	0.131592639985688	0.029950	-1	GO:0005743,mitochondrial inner membrane;GO:0005753,mitochondrial proton-transporting ATP synthase complex;GO:0000274,mitochondrial proton-transporting ATP synthase, stator stalk;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0045261,proton-transporting ATP synthase complex, catalytic core F(1)	GO:0046933,proton-transporting ATP synthase activity, rotational mechanism	GO:0006754,ATP biosynthetic process;GO:0015986,ATP synthesis coupled proton transport;GO:0042407,cristae formation;GO:0042776,mitochondrial ATP synthesis coupled proton transport;GO:1902600,proton transmembrane transport	hsa:539,path:hsa00190,Oxidative phosphorylation;hsa:539,path:hsa04714,Thermogenesis;hsa:539,path:hsa05010,Alzheimer disease;hsa:539,path:hsa05012,Parkinson disease;hsa:539,path:hsa05016,Huntington disease
FRYL_HUMAN	O94915	FRYL	Protein furry homolog-like	0.040344205	0.037536637	0.060611259	0.036808204	0.038940421	0.0487097315	0.038940421	0.0487097315	0.799438219034322	0.484942	0	1.25087839959409	0.485050	0	GO:0005938,cell cortex;GO:0030427,site of polarized growth		GO:0000902,cell morphogenesis;GO:0031175,neuron projection development	
CO4A_HUMAN	P0C0L4	C4A	Complement C4-A	0.328894701	0.22132051	0.679398242	1.940792328	0.2751076055	1.310095285	0.2751076055	1.310095285	0.209990531719225	0.018729	-1	4.76211947182972	0.018849	1	GO:0030424,axon;GO:0072562,blood microparticle;GO:0030425,dendrite;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043025,neuronal cell body;GO:0005886,plasma membrane;GO:0045202,synapse	GO:0001849,complement component C1q complex binding;GO:0004866,endopeptidase inhibitor activity	GO:0044267,cellular protein metabolic process;GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:2000427,positive regulation of apoptotic cell clearance;GO:0043687,post-translational protein modification;GO:0030449,regulation of complement activation	hsa:720,path:hsa04610,Complement and coagulation cascades;hsa:720,path:hsa05322,Systemic lupus erythematosus;hsa:720,path:hsa05133,Pertussis;hsa:720,path:hsa05150,Staphylococcus aureus infection;hsa:721,path:hsa04610,Complement and coagulation cascades;hsa:721,path:hsa05322,Systemic lupus erythematosus;hsa:721,path:hsa05133,Pertussis;hsa:721,path:hsa05150,Staphylococcus aureus infection
NPM_HUMAN	P06748	NPM1	Nucleophosmin	6.777564367	9.915319174	2.671581114	0.636905801	8.3464417705	1.6542434575	8.3464417705	1.6542434575	5.04547364697678	0.062759	0	0.198197447845	0.062323	0	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0032993,protein-DNA complex;GO:1990904,ribonucleoprotein complex;GO:0031616,spindle pole centrosome	GO:0033613,activating transcription factor binding;GO:0003682,chromatin binding;GO:0001046,core promoter sequence-specific DNA binding;GO:0042393,histone binding;GO:0051059,NF-kappaB binding;GO:0042803,protein homodimerization activity;GO:0019901,protein kinase binding;GO:0004860,protein kinase inhibitor activity;GO:0043023,ribosomal large subunit binding;GO:0043024,ribosomal small subunit binding;GO:0003723,RNA binding;GO:0030957,Tat protein binding;GO:0003713,transcription coactivator activity;GO:0008134,transcription factor binding;GO:0051082,unfolded protein binding	GO:0007569,cell aging;GO:0034644,cellular response to UV;GO:0034080,CENP-A containing nucleosome assembly;GO:0007098,centrosome cycle;GO:0006338,chromatin remodeling;GO:0006281,DNA repair;GO:0006886,intracellular protein transport;GO:0043066,negative regulation of apoptotic process;GO:0008285,negative regulation of cell population proliferation;GO:0010826,negative regulation of centrosome duplication;GO:0044387,negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0006913,nucleocytoplasmic transport;GO:0006334,nucleosome assembly;GO:1902751,positive regulation of cell cycle G2/M phase transition;GO:0008284,positive regulation of cell population proliferation;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0045727,positive regulation of translation;GO:0008104,protein localization;GO:0046599,regulation of centriole replication;GO:0010824,regulation of centrosome duplication;GO:0060735,regulation of eIF2 alpha phosphorylation by dsRNA;GO:0032071,regulation of endodeoxyribonuclease activity;GO:0060699,regulation of endoribonuclease activity;GO:1902629,regulation of mRNA stability involved in cellular response to UV;GO:0006357,regulation of transcription by RNA polymerase II;GO:0042273,ribosomal large subunit biogenesis;GO:0000055,ribosomal large subunit export from nucleus;GO:0042274,ribosomal small subunit biogenesis;GO:0000056,ribosomal small subunit export from nucleus;GO:0042255,ribosome assembly;GO:0006407,rRNA export from nucleus;GO:0007165,signal transduction;GO:0016032,viral process	
ACAP2_HUMAN	Q15057	ACAP2	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2	2.55E-05	0.226055401	0.348394726	0.199291309	0.1130404505	0.2738430175	0.1130404505	0.2738430175	0.412792889634296	0.147354	0	2.42252234743173	0.147684	0	GO:0010008,endosome membrane;GO:0016020,membrane;GO:0001726,ruffle	GO:0005096,GTPase activator activity;GO:0046872,metal ion binding	GO:0030029,actin filament-based process;GO:1990090,cellular response to nerve growth factor stimulus;GO:0032456,endocytic recycling;GO:0043547,positive regulation of GTPase activity	hsa:23527,path:hsa04144,Endocytosis
RHOA_HUMAN	P61586	RHOA	Transforming protein RhoA	7.205665459	24.14623199	1.552668343	0.873764949	15.6759487245	1.213216646	15.6759487245	1.213216646	12.9209805818144	0.010046	1	0.0773935069144401	0.009905	-1	GO:0043296,apical junction complex;GO:0005938,cell cortex;GO:0030054,cell junction;GO:0071944,cell periphery;GO:0042995,cell projection;GO:0032154,cleavage furrow;GO:0031410,cytoplasmic vesicle;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0005789,endoplasmic reticulum membrane;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0101003,ficolin-1-rich granule membrane;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0043231,intracellular membrane-bounded organelle;GO:0030027,lamellipodium;GO:0030496,midbody;GO:0005886,plasma membrane;GO:0098794,postsynapse;GO:0030667,secretory granule membrane;GO:0031982,vesicle	GO:0003925,G protein activity;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0017022,myosin binding;GO:0019901,protein kinase binding	GO:0030036,actin cytoskeleton organization;GO:0031532,actin cytoskeleton reorganization;GO:0007015,actin filament organization;GO:0043297,apical junction assembly;GO:0038027,apolipoprotein A-I-mediated signaling pathway;GO:0034329,cell junction assembly;GO:0016477,cell migration;GO:1990869,cellular response to chemokine;GO:0071345,cellular response to cytokine stimulus;GO:0071222,cellular response to lipopolysaccharide;GO:0036089,cleavage furrow formation;GO:0030865,cortical cytoskeleton organization;GO:0031122,cytoplasmic microtubule organization;GO:0043542,endothelial cell migration;GO:0097498,endothelial tube lumen extension;GO:0048013,ephrin receptor signaling pathway;GO:0045198,establishment of epithelial cell apical/basal polarity;GO:0007163,establishment or maintenance of cell polarity;GO:0007186,G protein-coupled receptor signaling pathway;GO:1903673,mitotic cleavage furrow formation;GO:0090307,mitotic spindle assembly;GO:0050919,negative chemotaxis;GO:0050771,negative regulation of axonogenesis;GO:0090051,negative regulation of cell migration involved in sprouting angiogenesis;GO:0045792,negative regulation of cell size;GO:0010812,negative regulation of cell-substrate adhesion;GO:0043312,neutrophil degranulation;GO:0043931,ossification involved in bone maturation;GO:0048015,phosphatidylinositol-mediated signaling;GO:0050772,positive regulation of axonogenesis;GO:0032467,positive regulation of cytokinesis;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:1904996,positive regulation of leukocyte adhesion to vascular endothelial cell;GO:0060193,positive regulation of lipase activity;GO:0045666,positive regulation of neuron differentiation;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:0071902,positive regulation of protein serine/threonine kinase activity;GO:0051496,positive regulation of stress fiber assembly;GO:2000406,positive regulation of T cell migration;GO:0016579,protein deubiquitination;GO:0032956,regulation of actin cytoskeleton organization;GO:0030334,regulation of cell migration;GO:2000145,regulation of cell motility;GO:0008360,regulation of cell shape;GO:0051893,regulation of focal adhesion assembly;GO:1905274,regulation of modification of postsynaptic actin cytoskeleton;GO:0033688,regulation of osteoblast proliferation;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007266,Rho protein signal transduction;GO:0035385,Roundabout signaling pathway;GO:1902766,skeletal muscle satellite cell migration;GO:0043149,stress fiber assembly;GO:0021762,substantia nigra development;GO:0034446,substrate adhesion-dependent cell spreading;GO:0061383,trabecula morphogenesis;GO:0007179,transforming growth factor beta receptor signaling pathway;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:0016032,viral process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0044319,wound healing, spreading of cells;GO:0007264,small GTPase mediated signal transduction	hsa:387,path:hsa04014,Ras signaling pathway;hsa:387,path:hsa04015,Rap1 signaling pathway;hsa:387,path:hsa04310,Wnt signaling pathway;hsa:387,path:hsa04350,TGF-beta signaling pathway;hsa:387,path:hsa04072,Phospholipase D signaling pathway;hsa:387,path:hsa04071,Sphingolipid signaling pathway;hsa:387,path:hsa04024,cAMP signaling pathway;hsa:387,path:hsa04022,cGMP-PKG signaling pathway;hsa:387,path:hsa04150,mTOR signaling pathway;hsa:387,path:hsa04144,Endocytosis;hsa:387,path:hsa04510,Focal adhesion;hsa:387,path:hsa04520,Adherens junction;hsa:387,path:hsa04530,Tight junction;hsa:387,path:hsa04810,Regulation of actin cytoskeleton;hsa:387,path:hsa04611,Platelet activation;hsa:387,path:hsa04621,NOD-like receptor signaling pathway;hsa:387,path:hsa04625,C-type lectin receptor signaling pathway;hsa:387,path:hsa04660,T cell receptor signaling pathway;hsa:387,path:hsa04670,Leukocyte transendothelial migration;hsa:387,path:hsa04062,Chemokine signaling pathway;hsa:387,path:hsa04921,Oxytocin signaling pathway;hsa:387,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:387,path:hsa04270,Vascular smooth muscle contraction;hsa:387,path:hsa04972,Pancreatic secretion;hsa:387,path:hsa04722,Neurotrophin signaling pathway;hsa:387,path:hsa04360,Axon guidance;hsa:387,path:hsa05200,Pathways in cancer;hsa:387,path:hsa05206,MicroRNAs in cancer;hsa:387,path:hsa05205,Proteoglycans in cancer;hsa:387,path:hsa05203,Viral carcinogenesis;hsa:387,path:hsa05210,Colorectal cancer;hsa:387,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:387,path:hsa05130,Pathogenic Escherichia coli infection;hsa:387,path:hsa05132,Salmonella infection;hsa:387,path:hsa05131,Shigellosis;hsa:387,path:hsa05135,Yersinia infection;hsa:387,path:hsa05133,Pertussis;hsa:387,path:hsa05152,Tuberculosis;hsa:387,path:hsa05100,Bacterial invasion of epithelial cells;hsa:387,path:hsa05163,Human cytomegalovirus infection
CLH1_HUMAN	Q00610	CLTC	Clathrin heavy chain 1	56.34097487	59.05572608	86.14482063	80.96363988	57.698350475	83.554230255	57.698350475	83.554230255	0.690549722005814	0.396847	0	1.44812164589009	0.397050	0	GO:0030118,clathrin coat;GO:0030132,clathrin coat of coated pit;GO:0030130,clathrin coat of trans-Golgi network vesicle;GO:0071439,clathrin complex;GO:0045334,clathrin-coated endocytic vesicle;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0030136,clathrin-coated vesicle;GO:0005829,cytosol;GO:0036020,endolysosome membrane;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:1903561,extracellular vesicle;GO:0005925,focal adhesion;GO:0005764,lysosome;GO:0042470,melanosome;GO:0016020,membrane;GO:0072686,mitotic spindle;GO:1990498,mitotic spindle microtubule;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0005819,spindle;GO:0032588,trans-Golgi network membrane	GO:0032051,clathrin light chain binding;GO:0097718,disordered domain specific binding;GO:0003725,double-stranded RNA binding;GO:0050750,low-density lipoprotein particle receptor binding;GO:0019901,protein kinase binding;GO:0003723,RNA binding;GO:0005198,structural molecule activity;GO:1990381,ubiquitin-specific protease binding	GO:0150093,amyloid-beta clearance by transcytosis;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0006914,autophagy;GO:0051301,cell division;GO:0048268,clathrin coat assembly;GO:0072583,clathrin-dependent endocytosis;GO:0006886,intracellular protein transport;GO:0034383,low-density lipoprotein particle clearance;GO:0032802,low-density lipoprotein particle receptor catabolic process;GO:0061024,membrane organization;GO:0000278,mitotic cell cycle;GO:1900126,negative regulation of hyaluronan biosynthetic process;GO:1903077,negative regulation of protein localization to plasma membrane;GO:0001649,osteoblast differentiation;GO:0006892,post-Golgi vesicle-mediated transport;GO:0031623,receptor internalization;GO:0006898,receptor-mediated endocytosis;GO:0060236,regulation of mitotic spindle organization;GO:0042147,retrograde transport, endosome to Golgi;GO:0033572,transferrin transport;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0016192,vesicle-mediated transport	hsa:1213,path:hsa04144,Endocytosis;hsa:1213,path:hsa04142,Lysosome;hsa:1213,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:1213,path:hsa04721,Synaptic vesicle cycle;hsa:1213,path:hsa05016,Huntington disease;hsa:1213,path:hsa05100,Bacterial invasion of epithelial cells
ENDD1_HUMAN	O94919	ENDOD1	Endonuclease domain-containing 1 protein	0.234726338	0.221468515	0.407855381	0.924479351	0.2280974265	0.666167366	0.2280974265	0.666167366	0.342402582506571	0.091174	0	2.92053871988775	0.091462	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0016020,membrane	GO:0004519,endonuclease activity;GO:0046872,metal ion binding;GO:0003676,nucleic acid binding	GO:0002576,platelet degranulation	
PSME2_HUMAN	Q9UL46	PSME2	Proteasome activator complex subunit 2	8.849181154	4.677748874	12.02212193	9.716652114	6.763465014	10.869387022	6.763465014	10.869387022	0.622248982422884	0.336995	0	1.60707374097463	0.337255	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0008537,proteasome activator complex;GO:0000502,proteasome complex	GO:0061133,endopeptidase activator activity;GO:0042802,identical protein binding	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0035722,interleukin-12-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0010950,positive regulation of endopeptidase activity;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:2000045,regulation of G1/S transition of mitotic cell cycle;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061136,regulation of proteasomal protein catabolic process;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5721,path:hsa03050,Proteasome;hsa:5721,path:hsa04612,Antigen processing and presentation
PLP2_HUMAN	Q04941	PLP2	Proteolipid protein 2	6.175588004	6.915664646	0.635580868	0.91832684	6.545626325	0.776953854	6.545626325	0.776953854	8.42472984888495	0.024757	1	0.118698168123736	0.024497	-1	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0019956,chemokine binding;GO:0015075,ion transmembrane transporter activity	GO:0006935,chemotaxis;GO:0019221,cytokine-mediated signaling pathway;GO:0006811,ion transport	
SRS10_HUMAN	O75494	SRSF10	Serine/arginine-rich splicing factor 10	0.794006198	1.485026386	0.366489623	0.092292022	1.139516292	0.2293908225	1.139516292	0.2293908225	4.96757577125824	0.064394	0	0.201305434692284	0.063952	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003723,RNA binding;GO:0050733,RS domain binding;GO:0051082,unfolded protein binding	GO:0016482,cytosolic transport;GO:0006376,mRNA splice site selection;GO:0000398,mRNA splicing, via spliceosome;GO:0048025,negative regulation of mRNA splicing, via spliceosome;GO:0048024,regulation of mRNA splicing, via spliceosome;GO:0006355,regulation of transcription, DNA-templated;GO:0000375,RNA splicing, via transesterification reactions;GO:0000244,spliceosomal tri-snRNP complex assembly	hsa:10772,path:hsa03040,Spliceosome
NIBA2_HUMAN	Q96TA1	NIBAN2	Protein Niban 2	2.580549407	2.883590019	4.710578459	4.357856345	2.732069713	4.534217402	2.732069713	4.534217402	0.602544931302789	0.319230	0	1.65962727101173	0.319504	0	GO:0005912,adherens junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0045296,cadherin binding;GO:0003713,transcription coactivator activity	GO:0007411,axon guidance;GO:0030154,cell differentiation;GO:0032274,gonadotropin secretion;GO:0044029,hypomethylation of CpG island;GO:0016525,negative regulation of angiogenesis;GO:0043066,negative regulation of apoptotic process;GO:0008285,negative regulation of cell population proliferation;GO:2000279,negative regulation of DNA biosynthetic process;GO:0045746,negative regulation of Notch signaling pathway;GO:0045892,negative regulation of transcription, DNA-templated;GO:0030948,negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0040019,positive regulation of embryonic development;GO:0048743,positive regulation of skeletal muscle fiber development;GO:2000679,positive regulation of transcription regulatory region DNA binding;GO:0045893,positive regulation of transcription, DNA-templated	
WASC5_HUMAN	Q12768	WASHC5	WASH complex subunit 5	0.857068653	1.286123462	1.547634847	1.284718939	1.0715960575	1.416176893	1.0715960575	1.416176893	0.756682348650636	0.451547	0	1.32155851366596	0.451692	0	GO:0005829,cytosol;GO:0005769,early endosome;GO:0005783,endoplasmic reticulum;GO:0005768,endosome;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0005654,nucleoplasm;GO:0071203,WASH complex		GO:0030041,actin filament polymerization;GO:0034629,cellular protein-containing complex localization;GO:0016197,endosomal transport;GO:0140285,endosome fission;GO:0007032,endosome organization;GO:0007040,lysosome organization;GO:0001556,oocyte maturation;GO:0040038,polar body extrusion after meiotic divisions;GO:0010976,positive regulation of neuron projection development;GO:0015031,protein transport;GO:0051125,regulation of actin nucleation;GO:0097494,regulation of vesicle size;GO:0090306,spindle assembly involved in meiosis	hsa:9897,path:hsa04144,Endocytosis
GTR1_HUMAN	P11166	SLC2A1	Solute carrier family 2, facilitated glucose transporter member 1	1.293105302	1.079022854	2.667109266	13.62186591	1.186064078	8.144487588	1.186064078	8.144487588	0.145627832958765	0.004144	-1	6.86681920401269	0.004184	1	GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0072562,blood microparticle;GO:0005901,caveola;GO:0030864,cortical actin cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0001939,female pronucleus;GO:0000139,Golgi membrane;GO:0005887,integral component of plasma membrane;GO:0014704,intercalated disc;GO:0042470,melanosome;GO:0016020,membrane;GO:0030496,midbody;GO:0001917,photoreceptor inner segment;GO:0005886,plasma membrane;GO:0098793,presynapse;GO:0042383,sarcolemma;GO:0030018,Z disc;GO:0016021,integral component of membrane	GO:0055056,D-glucose transmembrane transporter activity;GO:0033300,dehydroascorbic acid transmembrane transporter activity;GO:0005355,glucose transmembrane transporter activity;GO:0042802,identical protein binding;GO:0019900,kinase binding;GO:0005324,long-chain fatty acid transporter activity;GO:0043621,protein self-association;GO:0042910,xenobiotic transmembrane transporter activity;GO:0022857,transmembrane transporter activity	GO:0071474,cellular hyperosmotic response;GO:0042149,cellular response to glucose starvation;GO:0071260,cellular response to mechanical stimulus;GO:0007417,central nervous system development;GO:0021987,cerebral cortex development;GO:0007565,female pregnancy;GO:0098708,glucose import across plasma membrane;GO:1904659,glucose transmembrane transport;GO:0019852,L-ascorbic acid metabolic process;GO:0005989,lactose biosynthetic process;GO:0015911,long-chain fatty acid import across plasma membrane;GO:0045494,photoreceptor cell maintenance;GO:0065003,protein-containing complex assembly;GO:0010827,regulation of glucose transmembrane transport;GO:0050796,regulation of insulin secretion;GO:0001666,response to hypoxia;GO:0032868,response to insulin;GO:1904016,response to Thyroglobulin triiodothyronine;GO:0150104,transport across blood-brain barrier	hsa:6513,path:hsa04066,HIF-1 signaling pathway;hsa:6513,path:hsa04911,Insulin secretion;hsa:6513,path:hsa04922,Glucagon signaling pathway;hsa:6513,path:hsa04920,Adipocytokine signaling pathway;hsa:6513,path:hsa04919,Thyroid hormone signaling pathway;hsa:6513,path:hsa04976,Bile secretion;hsa:6513,path:hsa05200,Pathways in cancer;hsa:6513,path:hsa05230,Central carbon metabolism in cancer;hsa:6513,path:hsa05211,Renal cell carcinoma;hsa:6513,path:hsa04931,Insulin resistance;hsa:6513,path:hsa05166,Human T-cell leukemia virus 1 infection
PUM3_HUMAN	Q15397	PUM3	Pumilio homolog 3	0.127008097	0.086471885	0.096686696	0.084290667	0.106739991	0.0904886815	0.106739991	0.0904886815	1.17959494193757	0.379397	0	0.847748633405824	0.379088	0	GO:0005694,chromosome;GO:0005783,endoplasmic reticulum;GO:0005730,nucleolus;GO:0005654,nucleoplasm	GO:0003677,DNA binding;GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0010835,regulation of protein ADP-ribosylation;GO:0006417,regulation of translation	
SSRG_HUMAN	Q9UNL2	SSR3	Translocon-associated protein subunit gamma	0.292153237	0.930226585	0.112669668	2.490538337	0.611189911	1.3016040025	0.611189911	1.3016040025	0.469566711400766	0.197408	0	2.12962285383667	0.197743	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane		GO:0006614,SRP-dependent cotranslational protein targeting to membrane	hsa:6747,path:hsa04141,Protein processing in endoplasmic reticulum
ACAD9_HUMAN	Q9H845	ACAD9	Complex I assembly factor ACAD9, mitochondrial	0.491453884	1.02884502	1.069980451	1.247971117	0.760149452	1.158975784	0.760149452	1.158975784	0.655880357893656	0.366840	0	1.52466831483028	0.367072	0	GO:0030425,dendrite;GO:0005743,mitochondrial inner membrane;GO:0031966,mitochondrial membrane;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0000062,fatty-acyl-CoA binding;GO:0050660,flavin adenine dinucleotide binding;GO:0004466,long-chain-acyl-CoA dehydrogenase activity;GO:0070991,medium-chain-acyl-CoA dehydrogenase activity;GO:0017099,very-long-chain-acyl-CoA dehydrogenase activity;GO:0003995,acyl-CoA dehydrogenase activity;GO:0016627,oxidoreductase activity, acting on the CH-CH group of donors	GO:0001676,long-chain fatty acid metabolic process;GO:0051791,medium-chain fatty acid metabolic process;GO:0032981,mitochondrial respiratory chain complex I assembly	
CLCB_HUMAN	P09497	CLTB	Clathrin light chain B	0.897480806	0.804413188	0.398616464	0.981484778	0.850946997	0.690050621	0.850946997	0.690050621	1.23316604768333	0.365235	0	0.810920801686547	0.364899	0	GO:0060170,ciliary membrane;GO:0030118,clathrin coat;GO:0030132,clathrin coat of coated pit;GO:0030130,clathrin coat of trans-Golgi network vesicle;GO:0030125,clathrin vesicle coat;GO:0045334,clathrin-coated endocytic vesicle;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0005886,plasma membrane;GO:0099631,postsynaptic endocytic zone cytoplasmic component;GO:0098835,presynaptic endocytic zone membrane;GO:0030672,synaptic vesicle membrane;GO:0005802,trans-Golgi network	GO:0032050,clathrin heavy chain binding;GO:0042277,peptide binding;GO:0005198,structural molecule activity	GO:0048268,clathrin coat assembly;GO:0072583,clathrin-dependent endocytosis;GO:0006886,intracellular protein transport;GO:0061024,membrane organization;GO:0016192,vesicle-mediated transport	hsa:1212,path:hsa04144,Endocytosis;hsa:1212,path:hsa04142,Lysosome;hsa:1212,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:1212,path:hsa04721,Synaptic vesicle cycle;hsa:1212,path:hsa05016,Huntington disease;hsa:1212,path:hsa05100,Bacterial invasion of epithelial cells
XYLK_HUMAN	O75063	FAM20B	Glycosaminoglycan xylosylkinase	0.133612045	0.144948333	0.055859415	2.55E-05	0.139280189	0.0279424575	0.139280189	0.0279424575	4.98453613108296	0.064033	0	0.200620473741603	0.063592	0	GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0005654,nucleoplasm	GO:0005524,ATP binding;GO:0016301,kinase activity;GO:0046872,metal ion binding;GO:0016773,phosphotransferase activity, alcohol group as acceptor	GO:0030166,proteoglycan biosynthetic process	
PEDF_HUMAN	P36955	SERPINF1	Pigment epithelium-derived factor	6.253884817	6.861910014	5.112246431	14.78148687	6.5578974155	9.9468666505	6.5578974155	9.9468666505	0.659292784946539	0.369829	0	1.51677679906824	0.370059	0	GO:0043203,axon hillock;GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0042470,melanosome;GO:0048471,perinuclear region of cytoplasm	GO:0004867,serine-type endopeptidase inhibitor activity	GO:0007568,aging;GO:0071279,cellular response to cobalt ion;GO:0071549,cellular response to dexamethasone stimulus;GO:0071333,cellular response to glucose stimulus;GO:0071300,cellular response to retinoic acid;GO:0001822,kidney development;GO:0016525,negative regulation of angiogenesis;GO:0010951,negative regulation of endopeptidase activity;GO:0010596,negative regulation of endothelial cell migration;GO:0060770,negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0010629,negative regulation of gene expression;GO:0050728,negative regulation of inflammatory response;GO:1901215,negative regulation of neuron death;GO:0042698,ovulation cycle;GO:0050769,positive regulation of neurogenesis;GO:0010976,positive regulation of neuron projection development;GO:0010447,response to acidic pH;GO:0046685,response to arsenic-containing substance;GO:1901652,response to peptide;GO:0060041,retina development in camera-type eye;GO:0007614,short-term memory	hsa:5176,path:hsa04310,Wnt signaling pathway
CO8A_HUMAN	P07357	C8A	Complement component C8 alpha chain	0.5713855	0.664568943	0.710339203	0.885779076	0.6179772215	0.7980591395	0.6179772215	0.7980591395	0.774350158920773	0.465542	0	1.29140543006244	0.465671	0	GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0016020,membrane;GO:0005579,membrane attack complex	GO:0001848,complement binding;GO:0044877,protein-containing complex binding	GO:0006956,complement activation;GO:0006957,complement activation, alternative pathway;GO:0006958,complement activation, classical pathway;GO:0019835,cytolysis;GO:0006955,immune response;GO:0030449,regulation of complement activation	hsa:731,path:hsa04610,Complement and coagulation cascades;hsa:731,path:hsa05322,Systemic lupus erythematosus;hsa:731,path:hsa05020,Prion diseases;hsa:731,path:hsa05146,Amoebiasis
NCKPL_HUMAN	P55160	NCKAP1L	Nck-associated protein 1-like	0.627760109	0.604130045	1.101722029	0.870340213	0.615945077	0.986031121	0.615945077	0.986031121	0.624671031047508	0.339166	0	1.60084260402328	0.339423	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0101003,ficolin-1-rich granule membrane;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0031209,SCAR complex;GO:0030667,secretory granule membrane	GO:0005096,GTPase activator activity;GO:0030295,protein kinase activator activity;GO:0044877,protein-containing complex binding	GO:0070358,actin polymerization-dependent cell motility;GO:0001782,B cell homeostasis;GO:0050853,B cell receptor signaling pathway;GO:0016477,cell migration;GO:0000902,cell morphogenesis;GO:0030031,cell projection assembly;GO:0006935,chemotaxis;GO:0030866,cortical actin cytoskeleton organization;GO:0048821,erythrocyte development;GO:0034101,erythrocyte homeostasis;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0030011,maintenance of cell polarity;GO:0002262,myeloid cell homeostasis;GO:0043066,negative regulation of apoptotic process;GO:0032700,negative regulation of interleukin-17 production;GO:0032715,negative regulation of interleukin-6 production;GO:0035509,negative regulation of myosin-light-chain-phosphatase activity;GO:0048812,neuron projection morphogenesis;GO:0030593,neutrophil chemotaxis;GO:0043312,neutrophil degranulation;GO:0030838,positive regulation of actin filament polymerization;GO:0045579,positive regulation of B cell differentiation;GO:0030890,positive regulation of B cell proliferation;GO:0043372,positive regulation of CD4-positive, alpha-beta T cell differentiation;GO:0043378,positive regulation of CD8-positive, alpha-beta T cell differentiation;GO:0033630,positive regulation of cell adhesion mediated by integrin;GO:0045648,positive regulation of erythrocyte differentiation;GO:0045588,positive regulation of gamma-delta T cell differentiation;GO:0045621,positive regulation of lymphocyte differentiation;GO:0090023,positive regulation of neutrophil chemotaxis;GO:0060100,positive regulation of phagocytosis, engulfment;GO:0042327,positive regulation of phosphorylation;GO:0042102,positive regulation of T cell proliferation;GO:0065003,protein-containing complex assembly;GO:0042493,response to drug;GO:0043029,T cell homeostasis;GO:0048010,vascular endothelial growth factor receptor signaling pathway	hsa:3071,path:hsa04810,Regulation of actin cytoskeleton;hsa:3071,path:hsa05130,Pathogenic Escherichia coli infection;hsa:3071,path:hsa05132,Salmonella infection
GSTM2_HUMAN	P28161	GSTM2	Glutathione S-transferase Mu 2	0.276737293	0.176164743	0.370166538	0.441988662	0.226451018	0.4060776	0.226451018	0.4060776	0.557654541890516	0.278209	0	1.79322488185944	0.278512	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0045171,intercellular bridge;GO:0016529,sarcoplasmic reticulum	GO:0019899,enzyme binding;GO:0005504,fatty acid binding;GO:0043295,glutathione binding;GO:0004602,glutathione peroxidase activity;GO:0004364,glutathione transferase activity;GO:0042803,protein homodimerization activity;GO:0005102,signaling receptor binding	GO:0070458,cellular detoxification of nitrogen compound;GO:0071313,cellular response to caffeine;GO:1901687,glutathione derivative biosynthetic process;GO:0006749,glutathione metabolic process;GO:0051122,hepoxilin biosynthetic process;GO:0043651,linoleic acid metabolic process;GO:0060315,negative regulation of ryanodine-sensitive calcium-release channel activity;GO:0018916,nitrobenzene metabolic process;GO:0060316,positive regulation of ryanodine-sensitive calcium-release channel activity;GO:0010881,regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0010880,regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0014809,regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion;GO:0055119,relaxation of cardiac muscle;GO:0042178,xenobiotic catabolic process	hsa:2946,path:hsa00480,Glutathione metabolism;hsa:2946,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:2946,path:hsa00982,Drug metabolism - cytochrome P450;hsa:2946,path:hsa00983,Drug metabolism - other enzymes;hsa:2946,path:hsa05200,Pathways in cancer;hsa:2946,path:hsa05204,Chemical carcinogenesis;hsa:2946,path:hsa05225,Hepatocellular carcinoma;hsa:2946,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:2946,path:hsa01524,Platinum drug resistance
SRSF3_HUMAN	P84103	SRSF3	Serine/arginine-rich splicing factor 3	7.331679685	14.42460916	1.238883953	0.303975656	10.8781444225	0.7714298045	10.8781444225	0.7714298045	14.1012757856182	0.008236	1	0.0709155692862838	0.008114	-1	GO:0005737,cytoplasm;GO:0016607,nuclear speck;GO:0005654,nucleoplasm	GO:0043274,phospholipase binding;GO:0003723,RNA binding;GO:1990825,sequence-specific mRNA binding	GO:1990830,cellular response to leukemia inhibitory factor;GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0048024,regulation of mRNA splicing, via spliceosome;GO:0006405,RNA export from nucleus	hsa:6428,path:hsa03040,Spliceosome;hsa:6428,path:hsa05168,Herpes simplex virus 1 infection
LX15B_HUMAN	O15296	ALOX15B	Polyunsaturated fatty acid lipoxygenase ALOX15B	1.516595014	0.15706678	0.946628772	0.351830694	0.836830897	0.649229733	0.836830897	0.649229733	1.2889596000681	0.351306	0	0.77581950586129	0.350943	0	GO:0005912,adherens junction;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0019898,extrinsic component of membrane;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0050473,arachidonate 15-lipoxygenase activity;GO:0036403,arachidonate 8(S)-lipoxygenase activity;GO:0005509,calcium ion binding;GO:0005506,iron ion binding;GO:0016165,linoleate 13S-lipoxygenase activity;GO:1990136,linoleate 9S-lipoxygenase activity;GO:0008289,lipid binding;GO:0016702,oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	GO:0006915,apoptotic process;GO:0019369,arachidonic acid metabolic process;GO:1901696,cannabinoid biosynthetic process;GO:0071926,endocannabinoid signaling pathway;GO:0051122,hepoxilin biosynthetic process;GO:0043651,linoleic acid metabolic process;GO:0006629,lipid metabolic process;GO:0034440,lipid oxidation;GO:2001303,lipoxin A4 biosynthetic process;GO:0019372,lipoxygenase pathway;GO:0045786,negative regulation of cell cycle;GO:0030336,negative regulation of cell migration;GO:0008285,negative regulation of cell population proliferation;GO:0045926,negative regulation of growth;GO:0006644,phospholipid metabolic process;GO:0032722,positive regulation of chemokine production;GO:0045618,positive regulation of keratinocyte differentiation;GO:0010744,positive regulation of macrophage derived foam cell differentiation;GO:0035360,positive regulation of peroxisome proliferator activated receptor signaling pathway;GO:0030850,prostate gland development;GO:0030856,regulation of epithelial cell differentiation	hsa:247,path:hsa00590,Arachidonic acid metabolism;hsa:247,path:hsa04726,Serotonergic synapse
RNAS2_HUMAN	P10153	RNASE2	Non-secretory ribonuclease	0.1566225	0.520455594	0.067065976	2.55E-05	0.338539047	0.033545738	0.338539047	0.033545738	10.0918646356804	0.017159	1	0.0990897159345994	0.016954	-1	GO:0035578,azurophil granule lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0016829,lyase activity;GO:0003676,nucleic acid binding;GO:0004522,ribonuclease A activity;GO:0004540,ribonuclease activity	GO:0006935,chemotaxis;GO:0051607,defense response to virus;GO:0002227,innate immune response in mucosa;GO:0043312,neutrophil degranulation;GO:0006401,RNA catabolic process;GO:0090501,RNA phosphodiester bond hydrolysis	
RL15_HUMAN	P61313	RPL15	60S ribosomal protein L15	9.745201567	13.03964198	2.439694048	1.386708834	11.3924217735	1.913201441	11.3924217735	1.913201441	5.95463788044471	0.047296	1	0.16793632460574	0.046916	-1	GO:0031672,A band;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0016020,membrane;GO:0005634,nucleus;GO:0005840,ribosome	GO:0045296,cadherin binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0045471,response to ethanol;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6138,path:hsa03010,Ribosome
PK3C3_HUMAN	Q8NEB9	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3	0.03906053	0.055460029	0.110156586	0.058469665	0.0472602795	0.0843131255	0.0472602795	0.0843131255	0.56053288523861	0.280855	0	1.78401664975341	0.281156	0	GO:0044754,autolysosome;GO:0005930,axoneme;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005768,endosome;GO:0005770,late endosome;GO:0016020,membrane;GO:0030496,midbody;GO:0005777,peroxisome;GO:0030670,phagocytic vesicle membrane;GO:0000407,phagophore assembly site;GO:0035032,phosphatidylinositol 3-kinase complex, class III;GO:0034271,phosphatidylinositol 3-kinase complex, class III, type I;GO:0034272,phosphatidylinositol 3-kinase complex, class III, type II;GO:0045335,phagocytic vesicle	GO:0016303,1-phosphatidylinositol-3-kinase activity;GO:0005524,ATP binding;GO:0016301,kinase activity;GO:0052742,phosphatidylinositol kinase activity;GO:0004672,protein kinase activity	GO:0000045,autophagosome assembly;GO:0006914,autophagy;GO:0030242,autophagy of peroxisome;GO:0007049,cell cycle;GO:0051301,cell division;GO:0042149,cellular response to glucose starvation;GO:0045022,early endosome to late endosome transport;GO:0006897,endocytosis;GO:0016236,macroautophagy;GO:0006661,phosphatidylinositol biosynthetic process;GO:0046854,phosphatidylinositol phosphorylation;GO:0036092,phosphatidylinositol-3-phosphate biosynthetic process;GO:0048015,phosphatidylinositol-mediated signaling;GO:0006497,protein lipidation;GO:0032465,regulation of cytokinesis;GO:0034162,toll-like receptor 9 signaling pathway;GO:0007032,endosome organization;GO:0034497,protein localization to phagophore assembly site;GO:0016485,protein processing;GO:0050708,regulation of protein secretion;GO:0043201,response to leucine	hsa:5289,path:hsa00562,Inositol phosphate metabolism;hsa:5289,path:hsa04371,Apelin signaling pathway;hsa:5289,path:hsa04070,Phosphatidylinositol signaling system;hsa:5289,path:hsa04145,Phagosome;hsa:5289,path:hsa04140,Autophagy - animal;hsa:5289,path:hsa04136,Autophagy - other;hsa:5289,path:hsa05017,Spinocerebellar ataxia;hsa:5289,path:hsa05132,Salmonella infection;hsa:5289,path:hsa05131,Shigellosis;hsa:5289,path:hsa05152,Tuberculosis;hsa:5289,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection
GLOD4_HUMAN	Q9HC38	GLOD4	Glyoxalase domain-containing protein 4	3.235642778	1.060161078	2.770671495	3.181230048	2.147901928	2.9759507715	2.147901928	2.9759507715	0.721753178369066	0.423097	0	1.38551520099944	0.423273	0	GO:0070062,extracellular exosome;GO:0005739,mitochondrion	GO:0045296,cadherin binding		
ELNE_HUMAN	P08246	ELANE	Neutrophil elastase	4.384766255	12.61983011	3.731995796	20.26441616	8.5022981825	11.998205978	8.5022981825	11.998205978	0.70863079014395	0.412150	0	1.41117209964425	0.412337	0	GO:0035578,azurophil granule lumen;GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0045335,phagocytic vesicle;GO:0030141,secretory granule;GO:0035580,specific granule lumen;GO:0017053,transcription repressor complex	GO:0019955,cytokine binding;GO:0004175,endopeptidase activity;GO:0008201,heparin binding;GO:0008233,peptidase activity;GO:0002020,protease binding;GO:0004252,serine-type endopeptidase activity;GO:0003714,transcription corepressor activity	GO:0002438,acute inflammatory response to antigenic stimulus;GO:0019730,antimicrobial humoral response;GO:0002812,biosynthetic process of antibacterial peptides active against Gram-negative bacteria;GO:0006874,cellular calcium ion homeostasis;GO:0042742,defense response to bacterium;GO:0022617,extracellular matrix disassembly;GO:0002523,leukocyte migration involved in inflammatory response;GO:0032682,negative regulation of chemokine production;GO:0050922,negative regulation of chemotaxis;GO:0050728,negative regulation of inflammatory response;GO:0032717,negative regulation of interleukin-8 production;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0043312,neutrophil degranulation;GO:0070947,neutrophil-mediated killing of fungus;GO:0070945,neutrophil-mediated killing of gram-negative bacterium;GO:0006909,phagocytosis;GO:0050778,positive regulation of immune response;GO:0032757,positive regulation of interleukin-8 production;GO:1903238,positive regulation of leukocyte tethering or rolling;GO:0043406,positive regulation of MAP kinase activity;GO:0048661,positive regulation of smooth muscle cell proliferation;GO:0030163,protein catabolic process;GO:0006508,proteolysis;GO:0032496,response to lipopolysaccharide;GO:0009411,response to UV;GO:0001878,response to yeast	hsa:1991,path:hsa05202,Transcriptional misregulation in cancer;hsa:1991,path:hsa05322,Systemic lupus erythematosus
TRFL_HUMAN	P02788	LTF	Lactotransferrin	4.482531549	10.53382641	10.17530035	27.81940669	7.5081789795	18.99735352	7.5081789795	18.99735352	0.395222364609657	0.132570	0	2.53022118570555	0.132894	0	GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0005769,early endosome;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005634,nucleus;GO:0097013,phagocytic vesicle lumen;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0055037,recycling endosome;GO:0030141,secretory granule;GO:0042581,specific granule;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen	GO:0004869,cysteine-type endopeptidase inhibitor activity;GO:0003677,DNA binding;GO:0008201,heparin binding;GO:0005506,iron ion binding;GO:0001530,lipopolysaccharide binding;GO:0043539,protein serine/threonine kinase activator activity;GO:0004252,serine-type endopeptidase activity	GO:1990000,amyloid fibril formation;GO:0019731,antibacterial humoral response;GO:0019732,antifungal humoral response;GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0019730,antimicrobial humoral response;GO:0060349,bone morphogenesis;GO:0050829,defense response to Gram-negative bacterium;GO:0050830,defense response to Gram-positive bacterium;GO:0006959,humoral immune response;GO:0045087,innate immune response;GO:0002227,innate immune response in mucosa;GO:0006826,iron ion transport;GO:0031640,killing of cells of other organism;GO:0051673,membrane disruption in other organism;GO:0044793,negative regulation by host of viral process;GO:0043066,negative regulation of apoptotic process;GO:0032780,negative regulation of ATPase activity;GO:2000117,negative regulation of cysteine-type endopeptidase activity;GO:0031665,negative regulation of lipopolysaccharide-mediated signaling pathway;GO:0045837,negative regulation of membrane potential;GO:2001205,negative regulation of osteoclast development;GO:1900229,negative regulation of single-species biofilm formation in or on host organism;GO:2000308,negative regulation of tumor necrosis factor (ligand) superfamily member 11 production;GO:0045071,negative regulation of viral genome replication;GO:0048525,negative regulation of viral process;GO:0043312,neutrophil degranulation;GO:0001503,ossification;GO:1900159,positive regulation of bone mineralization involved in bone maturation;GO:1902732,positive regulation of chondrocyte proliferation;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0045669,positive regulation of osteoblast differentiation;GO:0033690,positive regulation of osteoblast proliferation;GO:0071902,positive regulation of protein serine/threonine kinase activity;GO:0034145,positive regulation of toll-like receptor 4 signaling pathway;GO:0001817,regulation of cytokine production;GO:0032680,regulation of tumor necrosis factor production;GO:0001895,retina homeostasis;GO:0033214,siderophore-dependent iron import into cell;GO:0006811,ion transport	
IPO4_HUMAN	Q8TEX9	IPO4	Importin-4	0.256315515	0.065847821	0.350616873	2.55E-05	0.161081668	0.1753211865	0.161081668	0.1753211865	0.918780389385512	0.461581	0	1.08839937329181	0.461446	0	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0016020,membrane;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0061608,nuclear import signal receptor activity;GO:0008139,nuclear localization sequence binding;GO:0031267,small GTPase binding	GO:0006335,DNA replication-dependent nucleosome assembly;GO:0006336,DNA replication-independent nucleosome assembly;GO:0006606,protein import into nucleus;GO:0006886,intracellular protein transport	
PBDC1_HUMAN	Q9BVG4	PBDC1	Protein PBDC1	0.367516415	0.324434721	0.408503756	0.316400567	0.345975568	0.3624521615	0.345975568	0.3624521615	0.95454132917345	0.448823	0	1.04762357525778	0.448660	0				
PUM1_HUMAN	Q14671	PUM1	Pumilio homolog 1	0.177914855	0.057337865	0.125063759	0.113028416	0.11762636	0.1190460875	0.11762636	0.1190460875	0.988074135573754	0.437332	0	1.0120698073119	0.437144	0	GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0000932,P-body	GO:0035198,miRNA binding;GO:0003730,mRNA 3'-UTR binding;GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0008344,adult locomotory behavior;GO:0061157,mRNA destabilization;GO:2000637,positive regulation of gene silencing by miRNA;GO:1900246,positive regulation of RIG-I signaling pathway;GO:0006892,post-Golgi vesicle-mediated transport;GO:0016441,posttranscriptional gene silencing;GO:0010608,posttranscriptional regulation of gene expression;GO:0035196,production of miRNAs involved in gene silencing by miRNA;GO:0051726,regulation of cell cycle;GO:0051983,regulation of chromosome segregation;GO:0060964,regulation of gene silencing by miRNA;GO:0043488,regulation of mRNA stability;GO:0007283,spermatogenesis;GO:0048863,stem cell differentiation	hsa:9698,path:hsa05017,Spinocerebellar ataxia
S10AB_HUMAN	P31949	S100A11	Protein S100-A11	9.194603813	14.8429783	4.754615573	5.09266105	12.0187910565	4.9236383115	12.0187910565	4.9236383115	2.44103857678336	0.178776	0	0.409661694620874	0.178207	0	GO:0005912,adherens junction;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005634,nucleus;GO:0001726,ruffle;GO:0034774,secretory granule lumen	GO:0098641,cadherin binding involved in cell-cell adhesion;GO:0005509,calcium ion binding;GO:0048306,calcium-dependent protein binding;GO:0042803,protein homodimerization activity;GO:0044548,S100 protein binding	GO:0008285,negative regulation of cell population proliferation;GO:0008156,negative regulation of DNA replication;GO:0043312,neutrophil degranulation;GO:0014911,positive regulation of smooth muscle cell migration;GO:0007165,signal transduction	
TANC1_HUMAN	Q9C0D5	TANC1	Protein TANC1	0.0186672	0.200701919	0.195258925	2.55E-05	0.1096845595	0.0976422125	0.1096845595	0.0976422125	1.12333136142322	0.395169	0	0.890209277815443	0.394892	0	GO:0043679,axon terminus;GO:0030425,dendrite;GO:0043025,neuronal cell body;GO:0014069,postsynaptic density		GO:0097062,dendritic spine maintenance;GO:0007520,myoblast fusion;GO:0008542,visual learning	
DNJC9_HUMAN	Q8WXX5	DNAJC9	DnaJ homolog subfamily C member 9	0.182937546	0.029257196	0.096729861	0.061389364	0.106097371	0.0790596125	0.106097371	0.0790596125	1.34199204429442	0.338785	0	0.745160900358219	0.338399	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005615,extracellular space;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0031072,heat shock protein binding	GO:0032781,positive regulation of ATPase activity	
ALG3_HUMAN	Q92685	ALG3	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase	0.127803939	0.130396536	0.250654092	0.171090847	0.1291002375	0.2108724695	0.1291002375	0.2108724695	0.612219498382647	0.327975	0	1.63340109657041	0.328242	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane	GO:0000033,alpha-1,3-mannosyltransferase activity;GO:0052925,dol-P-Man	GO:0006488,dolichol-linked oligosaccharide biosynthetic process;GO:0006486,protein glycosylation	hsa:10195,path:hsa00510,N-Glycan biosynthesis;hsa:10195,path:hsa00513,Various types of N-glycan biosynthesis
NOP56_HUMAN	O00567	NOP56	Nucleolar protein 56	0.488987551	1.719048391	1.387566437	0.511846859	1.104017971	0.949706648	1.104017971	0.949706648	1.16248314500585	0.384093	0	0.860227526133268	0.383794	0	GO:0031428,box C/D RNP complex;GO:0005737,cytoplasm;GO:0001650,fibrillar center;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0070761,pre-snoRNP complex;GO:0032040,small-subunit processome;GO:0005732,sno(s)RNA-containing ribonucleoprotein complex	GO:0045296,cadherin binding;GO:1990226,histone methyltransferase binding;GO:0003723,RNA binding;GO:0030515,snoRNA binding	GO:0006364,rRNA processing;GO:0042254,ribosome biogenesis	hsa:10528,path:hsa03008,Ribosome biogenesis in eukaryotes;hsa:10528,path:hsa05017,Spinocerebellar ataxia
SEPR_HUMAN	Q12884	FAP	Prolyl endopeptidase FAP	0.890719735	1.242895963	0.589476583	1.367544578	1.066807849	0.9785105805	1.066807849	0.9785105805	1.09023639627369	0.404906	0	0.917232265789226	0.404649	0	GO:0045177,apical part of cell;GO:0045178,basal part of cell;GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0016021,integral component of membrane;GO:0030027,lamellipodium;GO:0031258,lamellipodium membrane;GO:1905368,peptidase complex;GO:0005886,plasma membrane;GO:0032587,ruffle membrane	GO:0008239,dipeptidyl-peptidase activity;GO:0004175,endopeptidase activity;GO:0042802,identical protein binding;GO:0005178,integrin binding;GO:0008233,peptidase activity;GO:0002020,protease binding;GO:0042803,protein homodimerization activity;GO:0004252,serine-type endopeptidase activity;GO:0008236,serine-type peptidase activity	GO:0001525,angiogenesis;GO:0007155,cell adhesion;GO:0043542,endothelial cell migration;GO:1902362,melanocyte apoptotic process;GO:0097325,melanocyte proliferation;GO:0071850,mitotic cell cycle arrest;GO:0060244,negative regulation of cell proliferation involved in contact inhibition;GO:0010716,negative regulation of extracellular matrix disassembly;GO:1903054,negative regulation of extracellular matrix organization;GO:0071158,positive regulation of cell cycle arrest;GO:1900119,positive regulation of execution phase of apoptosis;GO:0006508,proteolysis;GO:0051603,proteolysis involved in cellular protein catabolic process;GO:0010710,regulation of collagen catabolic process;GO:0051917,regulation of fibrinolysis	
FKBP4_HUMAN	Q02790	FKBP4	Peptidyl-prolyl cis-trans isomerase FKBP4	0.722797728	1.182254288	2.113917315	3.80981638	0.952526008	2.9618668475	0.952526008	2.9618668475	0.321596498777111	0.076450	0	3.10948658894782	0.076718	0	GO:0044295,axonal growth cone;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005874,microtubule;GO:0005739,mitochondrion;GO:0043025,neuronal cell body;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm;GO:0032991,protein-containing complex	GO:0032767,copper-dependent protein binding;GO:0005528,FK506 binding;GO:0031072,heat shock protein binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity;GO:0030674,protein-macromolecule adaptor activity;GO:0003723,RNA binding;GO:0048156,tau protein binding	GO:0061077,chaperone-mediated protein folding;GO:0006825,copper ion transport;GO:0031115,negative regulation of microtubule polymerization;GO:0031111,negative regulation of microtubule polymerization or depolymerization;GO:0010977,negative regulation of neuron projection development;GO:0006457,protein folding;GO:0000413,protein peptidyl-prolyl isomerization;GO:1900034,regulation of cellular response to heat	hsa:2288,path:hsa04915,Estrogen signaling pathway
PP4R1_HUMAN	Q8TF05	PPP4R1	Serine/threonine-protein phosphatase 4 regulatory subunit 1	0.242625017	0.017598178	0.246283555	0.328438227	0.1301115975	0.287360891	0.1301115975	0.287360891	0.452781159771668	0.182323	0	2.20857246026819	0.182659	0	GO:0030289,protein phosphatase 4 complex;GO:0008287,protein serine/threonine phosphatase complex	GO:0019888,protein phosphatase regulator activity	GO:0006470,protein dephosphorylation;GO:0006468,protein phosphorylation;GO:0007165,signal transduction	
COCA1_HUMAN	Q99715	COL12A1	Collagen alpha-1(XII) chain	281.4475695	142.6309501	180.7625438	724.1896822	212.0392598	452.476113	212.0392598	452.476113	0.468619787228414	0.196552	0	2.13392611079092	0.196887	0	GO:0005595,collagen type XII trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1903561,extracellular vesicle;GO:0005581,collagen trimer	GO:0030020,extracellular matrix structural constituent conferring tensile strength	GO:0007155,cell adhesion;GO:0030199,collagen fibril organization;GO:0035987,endodermal cell differentiation	hsa:1303,path:hsa04974,Protein digestion and absorption
GOLI4_HUMAN	O00461	GOLIM4	Golgi integral membrane protein 4	0.121221805	1.950166706	0.18695996	2.55E-05	1.0356942555	0.09349273	1.0356942555	0.09349273	11.077805252879	0.014086	1	0.0902705885482243	0.013907	-1	GO:0005801,cis-Golgi network;GO:0030139,endocytic vesicle;GO:0010008,endosome membrane;GO:0005794,Golgi apparatus;GO:0032580,Golgi cisterna membrane;GO:0005796,Golgi lumen;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0030133,transport vesicle			
DNLI3_HUMAN	P49916	LIG3	DNA ligase 3	0.114328647	0.05270607	0.171572884	0.053989987	0.0835173585	0.1127814355	0.0835173585	0.1127814355	0.740523988985758	0.438513	0	1.35039514569896	0.438672	0	GO:0005737,cytoplasm;GO:0070421,DNA ligase III-XRCC1 complex;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0003677,DNA binding;GO:0003910,DNA ligase (ATP) activity;GO:0003909,DNA ligase activity;GO:0008270,zinc ion binding	GO:0006288,base-excision repair, DNA ligation;GO:0006287,base-excision repair, gap-filling;GO:0007049,cell cycle;GO:0051301,cell division;GO:0071897,DNA biosynthetic process;GO:0006266,DNA ligation;GO:0006302,double-strand break repair;GO:0097681,double-strand break repair via alternative nonhomologous end joining;GO:0000724,double-strand break repair via homologous recombination;GO:0006273,lagging strand elongation;GO:0043504,mitochondrial DNA repair;GO:0007005,mitochondrion organization;GO:0090298,negative regulation of mitochondrial DNA replication;GO:0006297,nucleotide-excision repair, DNA gap filling;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0006310,DNA recombination;GO:0006281,DNA repair;GO:0006260,DNA replication	hsa:3980,path:hsa03410,Base excision repair
DHB8_HUMAN	Q92506	HSD17B8	(3R)-3-hydroxyacyl-CoA dehydrogenase	0.087165807	0.029700422	0.149614857	0.123830433	0.0584331145	0.136722645	0.0584331145	0.136722645	0.427384318815658	0.159926	0	2.33981443860912	0.160259	0	GO:0005740,mitochondrial envelope;GO:0005759,mitochondrial matrix;GO:0005886,plasma membrane	GO:0044594,17-beta-hydroxysteroid dehydrogenase (NAD+) activity;GO:0072582,17-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:0003857,3-hydroxyacyl-CoA dehydrogenase activity;GO:0047025,3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity;GO:0004303,estradiol 17-beta-dehydrogenase activity;GO:0070404,NADH binding;GO:0016616,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0048038,quinone binding;GO:0047035,testosterone dehydrogenase (NAD+) activity	GO:0008209,androgen metabolic process;GO:0006703,estrogen biosynthetic process;GO:0006633,fatty acid biosynthetic process;GO:0046949,fatty-acyl-CoA biosynthetic process;GO:0051290,protein heterotetramerization	hsa:7923,path:hsa00061,Fatty acid biosynthesis;hsa:7923,path:hsa00140,Steroid hormone biosynthesis
GSH1_HUMAN	P48506	GCLC	Glutamate--cysteine ligase catalytic subunit	0.104069138	0.440750949	0.78655711	3.710146199	0.2724100435	2.2483516545	0.2724100435	2.2483516545	0.121159891938959	0.001743	-1	8.25355638732167	0.001764	1	GO:0005829,cytosol;GO:0017109,glutamate-cysteine ligase complex;GO:0005739,mitochondrion	GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0016595,glutamate binding;GO:0004357,glutamate-cysteine ligase activity;GO:0000287,magnesium ion binding;GO:0044877,protein-containing complex binding	GO:0097746,blood vessel diameter maintenance;GO:0045454,cell redox homeostasis;GO:0006534,cysteine metabolic process;GO:0006536,glutamate metabolic process;GO:0006750,glutathione biosynthetic process;GO:0043066,negative regulation of apoptotic process;GO:0045892,negative regulation of transcription, DNA-templated;GO:0009408,response to heat;GO:0009725,response to hormone;GO:0006979,response to oxidative stress;GO:0007568,aging;GO:0044344,cellular response to fibroblast growth factor stimulus;GO:0071372,cellular response to follicle-stimulating hormone stimulus;GO:0071333,cellular response to glucose stimulus;GO:0035729,cellular response to hepatocyte growth factor stimulus;GO:0032869,cellular response to insulin stimulus;GO:0071260,cellular response to mechanical stimulus;GO:0097069,cellular response to thyroxine stimulus;GO:0019852,L-ascorbic acid metabolic process;GO:2001237,negative regulation of extrinsic apoptotic signaling pathway;GO:2000490,negative regulation of hepatic stellate cell activation;GO:1901029,negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:0043524,negative regulation of neuron apoptotic process;GO:0031397,negative regulation of protein ubiquitination;GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0051900,regulation of mitochondrial depolarization;GO:0014823,response to activity;GO:0046685,response to arsenic-containing substance;GO:0046686,response to cadmium ion;GO:0044752,response to human chorionic gonadotropin;GO:0070555,response to interleukin-1;GO:0051409,response to nitrosative stress;GO:0007584,response to nutrient;GO:0009410,response to xenobiotic stimulus	hsa:2729,path:hsa00270,Cysteine and methionine metabolism;hsa:2729,path:hsa00480,Glutathione metabolism;hsa:2729,path:hsa04216,Ferroptosis
LACTB_HUMAN	P83111	LACTB	Serine beta-lactamase-like protein LACTB, mitochondrial	1.176159647	1.530519756	1.419566672	0.997705562	1.3533397015	1.208636117	1.3533397015	1.208636117	1.1197246900574	0.396213	0	0.893076672220866	0.395938	0	GO:0005829,cytosol;GO:0005739,mitochondrion	GO:0042802,identical protein binding;GO:0008233,peptidase activity	GO:0006629,lipid metabolic process;GO:0006508,proteolysis;GO:0019216,regulation of lipid metabolic process	
FRIH_HUMAN	P02794	FTH1	Ferritin heavy chain	16.29535905	28.46234794	11.06909651	1.02880003	22.378853495	6.04894827	22.378853495	6.04894827	3.69962719072815	0.101952	0	0.270297505247598	0.101425	0	GO:0044754,autolysosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0008043,intracellular ferritin complex;GO:0005634,nucleus;GO:1904724,tertiary granule lumen;GO:0016021,integral component of membrane	GO:0008199,ferric iron binding;GO:0008198,ferrous iron binding;GO:0004322,ferroxidase activity;GO:0005506,iron ion binding	GO:0006879,cellular iron ion homeostasis;GO:0006955,immune response;GO:0006880,intracellular sequestering of iron ion;GO:0006826,iron ion transport;GO:0008285,negative regulation of cell population proliferation;GO:0048147,negative regulation of fibroblast proliferation;GO:0043312,neutrophil degranulation;GO:0006892,post-Golgi vesicle-mediated transport	hsa:2495,path:hsa04216,Ferroptosis;hsa:2495,path:hsa04217,Necroptosis;hsa:2495,path:hsa04978,Mineral absorption
SAR1B_HUMAN	Q9Y6B6	SAR1B	GTP-binding protein SAR1b	0.37963597	1.592336565	0.162124119	2.55E-05	0.9859862675	0.0810748095	0.9859862675	0.0810748095	12.1614379803137	0.011497	1	0.082227118340672	0.011341	-1	GO:0030127,COPII vesicle coat;GO:0005829,cytosol;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0032580,Golgi cisterna membrane;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0046872,metal ion binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0061024,membrane organization;GO:0070863,positive regulation of protein exit from endoplasmic reticulum;GO:0003400,regulation of COPII vesicle coating;GO:0016050,vesicle organization;GO:0016192,vesicle-mediated transport	hsa:51128,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:51128,path:hsa05134,Legionellosis
F120A_HUMAN	Q9NZB2	FAM120A	Constitutive coactivator of PPAR-gamma-like protein 1	1.178452454	1.572373937	1.949878573	1.543335393	1.3754131955	1.746606983	1.3754131955	1.746606983	0.787477210893528	0.475762	0	1.26987801826713	0.475881	0	GO:0005829,cytosol;GO:0016020,membrane;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0003723,RNA binding		
TBL1R_HUMAN	Q9BZK7	TBL1XR1	F-box-like/WD repeat-containing protein TBL1XR1	0.407179673	0.443279102	0.780307015	0.725976376	0.4252293875	0.7531416955	0.4252293875	0.7531416955	0.564607417224054	0.284598	0	1.77114215912464	0.284897	0	GO:0000118,histone deacetylase complex;GO:0072686,mitotic spindle;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0017053,transcription repressor complex	GO:0008013,beta-catenin binding;GO:0042393,histone binding;GO:0047485,protein N-terminus binding;GO:0003714,transcription corepressor activity;GO:0000976,transcription regulatory region sequence-specific DNA binding	GO:0016575,histone deacetylation;GO:0030522,intracellular receptor signaling pathway;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0019216,regulation of lipid metabolic process;GO:0006357,regulation of transcription by RNA polymerase II;GO:0006367,transcription initiation from RNA polymerase II promoter	hsa:79718,path:hsa04310,Wnt signaling pathway
KCRU_HUMAN	P12532	CKMT1A	Creatine kinase U-type, mitochondrial	0.11247735	0.025170559	0.095084276	0.02486304	0.0688239545	0.059973658	0.0688239545	0.059973658	1.14756972969699	0.388257	0	0.871406742546303	0.387966	0	GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0004111,creatine kinase activity;GO:0016301,kinase activity	GO:0006600,creatine metabolic process;GO:0046314,phosphocreatine biosynthetic process	hsa:1159,path:hsa00330,Arginine and proline metabolism;hsa:548596,path:hsa00330,Arginine and proline metabolism
BLMH_HUMAN	Q13867	BLMH	Bleomycin hydrolase	1.078861589	0.821190473	1.413796574	1.426445667	0.950026031	1.4201211205	0.950026031	1.4201211205	0.668975355190487	0.378271	0	1.49482337763438	0.378493	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0004177,aminopeptidase activity;GO:0004180,carboxypeptidase activity;GO:0004197,cysteine-type endopeptidase activity;GO:0008234,cysteine-type peptidase activity;GO:0042802,identical protein binding	GO:0043418,homocysteine catabolic process;GO:0000209,protein polyubiquitination;GO:0006508,proteolysis;GO:0042493,response to drug;GO:0009636,response to toxic substance	
PLCD1_HUMAN	P51178	PLCD1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1	0.055583549	0.182054308	0.212243618	0.450001151	0.1188189285	0.3311223845	0.1188189285	0.3311223845	0.358836895546698	0.103489	0	2.78678143861565	0.103791	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005886,plasma membrane	GO:0005509,calcium ion binding;GO:0032794,GTPase activating protein binding;GO:0070300,phosphatidic acid binding;GO:0004435,phosphatidylinositol phospholipase C activity;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding;GO:0001786,phosphatidylserine binding	GO:0043647,inositol phosphate metabolic process;GO:0016042,lipid catabolic process;GO:0046488,phosphatidylinositol metabolic process;GO:0048015,phosphatidylinositol-mediated signaling;GO:0006644,phospholipid metabolic process	hsa:5333,path:hsa00562,Inositol phosphate metabolism;hsa:5333,path:hsa04020,Calcium signaling pathway;hsa:5333,path:hsa04070,Phosphatidylinositol signaling system;hsa:5333,path:hsa04919,Thyroid hormone signaling pathway;hsa:5333,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:5333,path:hsa05131,Shigellosis
CNN3_HUMAN	Q15417	CNN3	Calponin-3	45.32807934	14.5169914	20.00015567	1.652336472	29.92253537	10.826246071	29.92253537	10.826246071	2.76388834816463	0.152744	0	0.361809116010078	0.152175	0	GO:0015629,actin cytoskeleton;GO:0005912,adherens junction;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0005925,focal adhesion;GO:0043025,neuronal cell body;GO:0014069,postsynaptic density	GO:0003779,actin binding;GO:0098641,cadherin binding involved in cell-cell adhesion;GO:0005516,calmodulin binding;GO:0008017,microtubule binding	GO:0031032,actomyosin structure organization;GO:0030855,epithelial cell differentiation;GO:0032780,negative regulation of ATPase activity	
CERS2_HUMAN	Q96G23	CERS2	Ceramide synthase 2	0.330911662	0.314286292	0.662806613	0.23971324	0.322598977	0.4512599265	0.322598977	0.4512599265	0.714885054168443	0.417384	0	1.39882627867106	0.417566	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0016410,N-acyltransferase activity;GO:0050291,sphingosine N-acyltransferase activity;GO:0016740,transferase activity	GO:0046513,ceramide biosynthetic process;GO:0048681,negative regulation of axon regeneration;GO:1900148,negative regulation of Schwann cell migration;GO:1905045,negative regulation of Schwann cell proliferation involved in axon regeneration;GO:0019216,regulation of lipid metabolic process;GO:0030148,sphingolipid biosynthetic process;GO:0006665,sphingolipid metabolic process	hsa:29956,path:hsa00600,Sphingolipid metabolism;hsa:29956,path:hsa04071,Sphingolipid signaling pathway
PTH2_HUMAN	Q9Y3E5	PTRH2	Peptidyl-tRNA hydrolase 2, mitochondrial	0.481361969	0.571915752	0.054295381	0.014023605	0.5266388605	0.034159493	0.5266388605	0.034159493	15.4170572877062	0.006690	1	0.0648632213877426	0.006585	-1	GO:0005829,cytosol;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0016021,integral component of membrane	GO:0004045,aminoacyl-tRNA hydrolase activity	GO:0006915,apoptotic process;GO:2000811,negative regulation of anoikis;GO:0010629,negative regulation of gene expression;GO:2000210,positive regulation of anoikis	
EXOC2_HUMAN	Q96KP1	EXOC2	Exocyst complex component 2	0.454169645	0.633268877	1.018185445	0.84548368	0.543719261	0.9318345625	0.543719261	0.9318345625	0.583493339784765	0.301897	0	1.71381562019007	0.302184	0	GO:0005829,cytosol;GO:0000145,exocyst;GO:0090543,Flemming body;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0019901,protein kinase binding;GO:0047485,protein N-terminus binding;GO:0031267,small GTPase binding	GO:0060271,cilium assembly;GO:0006887,exocytosis;GO:0006893,Golgi to plasma membrane transport;GO:0015031,protein transport;GO:2000535,regulation of entry of bacterium into host cell	hsa:55770,path:hsa04014,Ras signaling pathway;hsa:55770,path:hsa05132,Salmonella infection
CUL1_HUMAN	Q13616	CUL1	Cullin-1	0.208408142	0.248445924	0.441331308	0.249037492	0.228427033	0.3451844	0.228427033	0.3451844	0.661753639503987	0.371981	0	1.51113638113051	0.372209	0	GO:0031461,cullin-RING ubiquitin ligase complex;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:1990452,Parkin-FBXW7-Cul1 ubiquitin ligase complex;GO:0005886,plasma membrane;GO:0019005,SCF ubiquitin ligase complex	GO:0031625,ubiquitin protein ligase binding;GO:0004842,ubiquitin-protein transferase activity	GO:0009887,animal organ morphogenesis;GO:0008283,cell population proliferation;GO:0006879,cellular iron ion homeostasis;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0000082,G1/S transition of mitotic cell cycle;GO:0000086,G2/M transition of mitotic cell cycle;GO:0070498,interleukin-1-mediated signaling pathway;GO:0097193,intrinsic apoptotic signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0043687,post-translational protein modification;GO:0070936,protein K48-linked ubiquitination;GO:0006513,protein monoubiquitination;GO:0000209,protein polyubiquitination;GO:0016567,protein ubiquitination;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0010265,SCF complex assembly;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0051403,stress-activated MAPK cascade;GO:0050852,T cell receptor signaling pathway;GO:0016032,viral process;GO:0016055,Wnt signaling pathway;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:8454,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:8454,path:hsa04120,Ubiquitin mediated proteolysis;hsa:8454,path:hsa04310,Wnt signaling pathway;hsa:8454,path:hsa04340,Hedgehog signaling pathway;hsa:8454,path:hsa04350,TGF-beta signaling pathway;hsa:8454,path:hsa04110,Cell cycle;hsa:8454,path:hsa04114,Oocyte meiosis;hsa:8454,path:hsa04710,Circadian rhythm;hsa:8454,path:hsa05200,Pathways in cancer;hsa:8454,path:hsa05131,Shigellosis;hsa:8454,path:hsa05170,Human immunodeficiency virus 1 infection
NNRE_HUMAN	Q8NCW5	NAXE	NAD(P)H-hydrate epimerase	0.413599199	0.283196994	0.52002037	0.090777639	0.3483980965	0.3053990045	0.3483980965	0.3053990045	1.14079643799232	0.390170	0	0.876580577127235	0.389883	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0046872,metal ion binding;GO:0052856,NADHX epimerase activity;GO:0052857,NADPHX epimerase activity;GO:0000166,nucleotide binding	GO:0006869,lipid transport;GO:0031580,membrane raft distribution;GO:0034356,NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0016525,negative regulation of angiogenesis;GO:0046496,nicotinamide nucleotide metabolic process;GO:0010874,regulation of cholesterol efflux;GO:0002040,sprouting angiogenesis	
ARHG7_HUMAN	Q14155	ARHGEF7	Rho guanine nucleotide exchange factor 7	0.112521528	0.109866242	0.273678798	0.409637096	0.111193885	0.341657947	0.111193885	0.341657947	0.325453822972249	0.079101	0	3.07263251931525	0.079374	0	GO:0005938,cell cortex;GO:0005813,centrosome;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0097431,mitotic spindle pole;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0098794,postsynapse;GO:0032991,protein-containing complex;GO:0001726,ruffle;GO:0005886,plasma membrane;GO:0000322,storage vacuole	GO:0043015,gamma-tubulin binding;GO:0005085,guanyl-nucleotide exchange factor activity;GO:0019901,protein kinase binding	GO:0048013,ephrin receptor signaling pathway;GO:0048041,focal adhesion assembly;GO:0007186,G protein-coupled receptor signaling pathway;GO:0007030,Golgi organization;GO:0035556,intracellular signal transduction;GO:0030032,lamellipodium assembly;GO:0042059,negative regulation of epidermal growth factor receptor signaling pathway;GO:1905833,negative regulation of microtubule nucleation;GO:0007399,nervous system development;GO:0043065,positive regulation of apoptotic process;GO:0010763,positive regulation of fibroblast migration;GO:0043547,positive regulation of GTPase activity;GO:2000394,positive regulation of lamellipodium morphogenesis;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:1904424,regulation of GTP binding;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007165,signal transduction;GO:0002244,hematopoietic progenitor cell differentiation;GO:0060124,positive regulation of growth hormone secretion;GO:0032092,positive regulation of protein binding	hsa:8874,path:hsa04810,Regulation of actin cytoskeleton;hsa:8874,path:hsa05135,Yersinia infection
CY1_HUMAN	P08574	CYC1	Cytochrome c1, heme protein, mitochondrial	1.461182328	0.578997797	1.230870061	0.438774283	1.0200900625	0.834822172	1.0200900625	0.834822172	1.22192497601753	0.368141	0	0.818380849583073	0.367810	0	GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005750,mitochondrial respiratory chain complex III;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0020037,heme binding;GO:0046872,metal ion binding;GO:0008121,ubiquinol-cytochrome-c reductase activity	GO:0006122,mitochondrial electron transport, ubiquinol to cytochrome c;GO:0033762,response to glucagon	hsa:1537,path:hsa00190,Oxidative phosphorylation;hsa:1537,path:hsa04260,Cardiac muscle contraction;hsa:1537,path:hsa04714,Thermogenesis;hsa:1537,path:hsa05010,Alzheimer disease;hsa:1537,path:hsa05012,Parkinson disease;hsa:1537,path:hsa05016,Huntington disease;hsa:1537,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
NIPS1_HUMAN	Q9BPW8	NIPSNAP1	Protein NipSnap homolog 1	0.985563782	0.521931776	0.902036655	0.508724958	0.753747779	0.7053808065	0.753747779	0.7053808065	1.06856859735097	0.411477	0	0.935831356525961	0.411234	0	GO:0005739,mitochondrion;GO:0097060,synaptic membrane	GO:0042165,neurotransmitter binding	GO:0019233,sensory perception of pain	
TMED7_HUMAN	Q9Y3B3	TMED7	Transmembrane emp24 domain-containing protein 7	3.729406604	10.6979396	1.190975281	5.901124547	7.213673102	3.546049914	7.213673102	3.546049914	2.03428414064901	0.221718	0	0.491573413968101	0.221172	0	GO:0030126,COPI vesicle coat;GO:0030127,COPII vesicle coat;GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0030133,transport vesicle		GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030,Golgi organization;GO:0006886,intracellular protein transport;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0015031,protein transport	
FBLN2_HUMAN	P98095	FBLN2	Fibulin-2	13.08883726	12.88135048	11.19608631	10.30769344	12.98509387	10.751889875	12.98509387	10.751889875	1.20770339177232	0.371866	0	0.828017878241184	0.371543	0	GO:0062023,collagen-containing extracellular matrix;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:1903561,extracellular vesicle	GO:0005509,calcium ion binding;GO:0050840,extracellular matrix binding;GO:0030023,extracellular matrix constituent conferring elasticity;GO:0005201,extracellular matrix structural constituent	GO:0030198,extracellular matrix organization;GO:0010811,positive regulation of cell-substrate adhesion	
QORX_HUMAN	Q53FA7	TP53I3	Quinone oxidoreductase PIG3	9.084938764	9.304859289	7.507199306	7.930128476	9.1948990265	7.718663891	9.1948990265	7.718663891	1.19125526857327	0.376246	0	0.839450642008635	0.375931	0	GO:0005829,cytosol	GO:0070402,NADPH binding;GO:0003960,NADPH;GO:0042803,protein homodimerization activity;GO:0048038,quinone binding;GO:0016491,oxidoreductase activity	GO:0006739,NADP metabolic process;GO:0042981,regulation of apoptotic process	hsa:9540,path:hsa04115,p53 signaling pathway
NMT1_HUMAN	P30419	NMT1	Glycylpeptide N-tetradecanoyltransferase 1	1.002114933	0.66359846	1.139270145	0.883974344	0.8328566965	1.0116222445	0.8328566965	1.0116222445	0.823288239289009	0.498422	0	1.21464142481083	0.498369	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0019898,extrinsic component of membrane;GO:0005739,mitochondrion;GO:0005886,plasma membrane	GO:0004379,glycylpeptide N-tetradecanoyltransferase activity;GO:0019107,myristoyltransferase activity	GO:0042180,cellular ketone metabolic process;GO:0001701,in utero embryonic development;GO:0018008,N-terminal peptidyl-glycine N-myristoylation;GO:0006499,N-terminal protein myristoylation;GO:1900740,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0022400,regulation of rhodopsin mediated signaling pathway	
COTL1_HUMAN	Q14019	COTL1	Coactosin-like protein	10.09753182	41.44920888	3.820886957	2.080063341	25.77337035	2.950475149	25.77337035	2.950475149	8.73532873467358	0.023041	1	0.114477660815517	0.022792	-1	GO:0030864,cortical actin cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0034774,secretory granule lumen	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0019899,enzyme binding	GO:0050832,defense response to fungus;GO:0043312,neutrophil degranulation;GO:0030833,regulation of actin filament polymerization	
TPPC4_HUMAN	Q9Y296	TRAPPC4	Trafficking protein particle complex subunit 4	0.151465829	0.079879138	0.172117851	0.077433178	0.1156724835	0.1247755145	0.1156724835	0.1247755145	0.927044732802925	0.458585	0	1.07869659857351	0.458443	0	GO:0005829,cytosol;GO:0030425,dendrite;GO:0005783,endoplasmic reticulum;GO:0000139,Golgi membrane;GO:0005795,Golgi stack;GO:0045211,postsynaptic membrane;GO:0045202,synapse;GO:0008021,synaptic vesicle;GO:0030008,TRAPP complex;GO:0005794,Golgi apparatus		GO:0006914,autophagy;GO:0048208,COPII vesicle coating;GO:0016358,dendrite development;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport	
SN_HUMAN	Q9BZZ2	SIGLEC1	Sialoadhesin	0.012227143	0.099277663	0.138252194	0.03222991	0.055752403	0.085241052	0.055752403	0.085241052	0.654055782887335	0.365238	0	1.52892157850129	0.365472	0	GO:0005769,early endosome;GO:0005576,extracellular region;GO:0016021,integral component of membrane;GO:0005770,late endosome;GO:0005886,plasma membrane	GO:0030246,carbohydrate binding;GO:0046790,virion binding	GO:0098609,cell-cell adhesion;GO:0007160,cell-matrix adhesion;GO:0075512,clathrin-dependent endocytosis of virus by host cell;GO:0006954,inflammatory response	hsa:6614,path:hsa04514,Cell adhesion molecules (CAMs)
TBB5_HUMAN	P07437	TUBB	Tubulin beta chain	30.31637676	48.33791362	46.7301583	37.44213533	39.32714519	42.086146815	39.32714519	42.086146815	0.934443948097034	0.455927	0	1.07015514631613	0.455780	0	GO:0035578,azurophil granule lumen;GO:0044297,cell body;GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0045121,membrane raft;GO:0005874,microtubule;GO:0005641,nuclear envelope lumen;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0005525,GTP binding;GO:0032794,GTPase activating protein binding;GO:0003924,GTPase activity;GO:0042288,MHC class I protein binding;GO:0019904,protein domain specific binding;GO:0044877,protein-containing complex binding;GO:0005200,structural constituent of cytoskeleton;GO:0005198,structural molecule activity;GO:0031625,ubiquitin protein ligase binding	GO:0051301,cell division;GO:0009987,cellular process;GO:0097711,ciliary basal body-plasma membrane docking;GO:0030705,cytoskeleton-dependent intracellular transport;GO:0000086,G2/M transition of mitotic cell cycle;GO:0000226,microtubule cytoskeleton organization;GO:0007017,microtubule-based process;GO:0000278,mitotic cell cycle;GO:0042267,natural killer cell mediated cytotoxicity;GO:0043312,neutrophil degranulation;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0050807,regulation of synapse organization;GO:0051225,spindle assembly	hsa:203068,path:hsa04145,Phagosome;hsa:203068,path:hsa04540,Gap junction;hsa:203068,path:hsa05130,Pathogenic Escherichia coli infection
NCDN_HUMAN	Q9UBB6	NCDN	Neurochondrin	0.333498208	0.265365772	0.137026312	0.281468454	0.29943199	0.209247383	0.29943199	0.209247383	1.43099514893336	0.319211	0	0.698814388536108	0.318792	0	GO:0005829,cytosol;GO:0030425,dendrite;GO:0010008,endosome membrane;GO:0016020,membrane;GO:0043025,neuronal cell body;GO:0043204,perikaryon;GO:0098794,postsynapse		GO:0045453,bone resorption;GO:0031175,neuron projection development;GO:0048168,regulation of neuronal synaptic plasticity	
EMC2_HUMAN	Q15006	EMC2	ER membrane protein complex subunit 2	0.376061553	0.091006674	0.556022089	0.170078639	0.2335341135	0.363050364	0.2335341135	0.363050364	0.643255417587186	0.355714	0	1.55459242574426	0.355957	0	GO:0005737,cytoplasm;GO:0072546,EMC complex;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0042406,extrinsic component of endoplasmic reticulum membrane;GO:0005634,nucleus		GO:0045050,protein insertion into ER membrane by stop-transfer membrane-anchor sequence;GO:0071816,tail-anchored membrane protein insertion into ER membrane	
HV404_HUMAN	A0A075B6R2	IGHV4-4	Immunoglobulin heavy variable 4-4	0.853918291	2.55E-05	0.447442638	1.658403175	0.4269718955	1.0529229065	0.4269718955	1.0529229065	0.405511071004513	0.141177	0	2.46602391772645	0.141504	0	GO:0009897,external side of plasma membrane;GO:0042571,immunoglobulin complex, circulating;GO:0005576,extracellular region;GO:0005886,plasma membrane	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006956,complement activation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response	
HEBP1_HUMAN	Q9NRV9	HEBP1	Heme-binding protein 1	1.260313498	4.176851409	0.392732689	0.14044444	2.7185824535	0.2665885645	2.7185824535	0.2665885645	10.1976709263536	0.016789	1	0.0980616071279296	0.016587	-1	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region	GO:0020037,heme binding	GO:0007623,circadian rhythm;GO:0007186,G protein-coupled receptor signaling pathway	
FKB11_HUMAN	Q9NYL4	FKBP11	Peptidyl-prolyl cis-trans isomerase FKBP11	0.545422153	0.640489828	0.141063005	0.02317245	0.5929559905	0.0821177275	0.5929559905	0.0821177275	7.22080369917689	0.033315	1	0.138488739157109	0.033003	-1	GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0003755,peptidyl-prolyl cis-trans isomerase activity	GO:0061077,chaperone-mediated protein folding	
M2OM_HUMAN	Q02978	SLC25A11	Mitochondrial 2-oxoglutarate/malate carrier protein	3.252613076	3.779240674	4.850649017	2.839638294	3.515926875	3.8451436555	3.515926875	3.8451436555	0.914381149315684	0.463188	0	1.0936358440333	0.463056	0	GO:0005887,integral component of plasma membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0016021,integral component of membrane	GO:0015297,antiporter activity;GO:0015140,malate transmembrane transporter activity;GO:0015131,oxaloacetate transmembrane transporter activity;GO:0015367,oxoglutarate;GO:0003723,RNA binding;GO:0015141,succinate transmembrane transporter activity;GO:0015116,sulfate transmembrane transporter activity;GO:0015117,thiosulfate transmembrane transporter activity	GO:0006094,gluconeogenesis;GO:0071423,malate transmembrane transport;GO:0015729,oxaloacetate transport;GO:0035435,phosphate ion transmembrane transport;GO:0071422,succinate transmembrane transport;GO:0008272,sulfate transport;GO:0015709,thiosulfate transport	
SMC3_HUMAN	Q9UQE7	SMC3	Structural maintenance of chromosomes protein 3	1.216429853	0.591895257	1.325069982	1.921107631	0.904162555	1.6230888065	0.904162555	1.6230888065	0.557062898455766	0.277664	0	1.79512942393417	0.277968	0	GO:0000785,chromatin;GO:0005694,chromosome;GO:0000775,chromosome, centromeric region;GO:0008278,cohesin complex;GO:0005829,cytosol;GO:0000800,lateral element;GO:0030893,meiotic cohesin complex;GO:0097431,mitotic spindle pole;GO:0016363,nuclear matrix;GO:0034991,nuclear meiotic cohesin complex;GO:0005654,nucleoplasm	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0048487,beta-tubulin binding;GO:0003682,chromatin binding;GO:0070840,dynein complex binding;GO:0036033,mediator complex binding;GO:0003777,microtubule motor activity;GO:0046982,protein heterodimerization activity	GO:0051301,cell division;GO:0006281,DNA repair;GO:0051321,meiotic cell cycle;GO:0000278,mitotic cell cycle;GO:0090307,mitotic spindle assembly;GO:0006275,regulation of DNA replication;GO:0007062,sister chromatid cohesion;GO:0019827,stem cell population maintenance	hsa:9126,path:hsa04110,Cell cycle;hsa:9126,path:hsa04114,Oocyte meiosis
RBBP4_HUMAN	Q09028	RBBP4	Histone-binding protein RBBP4	10.20091947	10.5760401	12.48762463	8.57063861	10.388479785	10.52913162	10.388479785	10.52913162	0.986641649085967	0.437814	0	1.01353921246524	0.437627	0	GO:0033186,CAF-1 complex;GO:0000785,chromatin;GO:0005829,cytosol;GO:0035098,ESC/E(Z) complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016581,NuRD complex;GO:0016589,NURF complex;GO:0032991,protein-containing complex;GO:0016580,Sin3 complex	GO:0042393,histone binding;GO:0042826,histone deacetylase binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0043044,ATP-dependent chromatin remodeling;GO:0007049,cell cycle;GO:0034080,CENP-A containing nucleosome assembly;GO:0031497,chromatin assembly;GO:0006338,chromatin remodeling;GO:0006260,DNA replication;GO:0006335,DNA replication-dependent nucleosome assembly;GO:0006336,DNA replication-independent nucleosome assembly;GO:0008285,negative regulation of cell population proliferation;GO:0070317,negative regulation of G0 to G1 transition;GO:0045814,negative regulation of gene expression, epigenetic;GO:0051726,regulation of cell cycle;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0060416,response to growth hormone;GO:0019058,viral life cycle	hsa:5928,path:hsa04218,Cellular senescence
LICH_HUMAN	P38571	LIPA	Lysosomal acid lipase/cholesteryl ester hydrolase	0.274278817	0.40313348	1.262790116	0.815037343	0.3387061485	1.0389137295	0.3387061485	1.0389137295	0.326019513345935	0.079493	0	3.06730106347627	0.079766	0	GO:0005829,cytosol;GO:0001650,fibrillar center;GO:0043231,intracellular membrane-bounded organelle;GO:0043202,lysosomal lumen;GO:0005764,lysosome;GO:0005654,nucleoplasm	GO:0016298,lipase activity;GO:0004771,sterol esterase activity	GO:0000902,cell morphogenesis;GO:0008283,cell population proliferation;GO:0048873,homeostasis of number of cells within a tissue;GO:0006954,inflammatory response;GO:0016042,lipid catabolic process;GO:0034383,low-density lipoprotein particle clearance;GO:0030324,lung development;GO:0016125,sterol metabolic process;GO:0048771,tissue remodeling;GO:0006629,lipid metabolic process	hsa:3988,path:hsa00100,Steroid biosynthesis;hsa:3988,path:hsa04142,Lysosome;hsa:3988,path:hsa04979,Cholesterol metabolism
S10A2_HUMAN	P29034	S100A2	Protein S100-A2	2.55E-05	0.239057032	0.054156398	2.55E-05	0.119541266	0.027090949	0.119541266	0.027090949	4.41259056668705	0.077943	0	0.226624243715137	0.077464	0		GO:0005509,calcium ion binding;GO:0048306,calcium-dependent protein binding;GO:0042802,identical protein binding;GO:0046914,transition metal ion binding	GO:0043542,endothelial cell migration	
CNPY2_HUMAN	Q9Y2B0	CNPY2	Protein canopy homolog 2	2.542791962	4.412992143	0.255478009	0.123838141	3.4778920525	0.189658075	3.4778920525	0.189658075	18.3376956267219	0.004400	1	0.0545324789087887	0.004324	-1	GO:0005783,endoplasmic reticulum		GO:0010629,negative regulation of gene expression;GO:1905599,positive regulation of low-density lipoprotein receptor activity;GO:0010988,regulation of low-density lipoprotein particle clearance	
IMDH2_HUMAN	P12268	IMPDH2	Inosine-5'-monophosphate dehydrogenase 2	1.965638038	3.65150375	2.906398519	1.159648376	2.808570894	2.0330234475	2.808570894	2.0330234475	1.38147491483863	0.329888	0	0.723864030579817	0.329487	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0005634,nucleus;GO:0005778,peroxisomal membrane;GO:0034774,secretory granule lumen	GO:0003677,DNA binding;GO:0003938,IMP dehydrogenase activity;GO:0046872,metal ion binding;GO:0000166,nucleotide binding;GO:0003723,RNA binding;GO:0003824,catalytic activity;GO:0042802,identical protein binding	GO:0007623,circadian rhythm;GO:0006177,GMP biosynthetic process;GO:0006183,GTP biosynthetic process;GO:0043312,neutrophil degranulation;GO:0009168,purine ribonucleoside monophosphate biosynthetic process;GO:0071353,cellular response to interleukin-4;GO:0046651,lymphocyte proliferation;GO:0006164,purine nucleotide biosynthetic process;GO:0060041,retina development in camera-type eye	hsa:3615,path:hsa00230,Purine metabolism;hsa:3615,path:hsa00983,Drug metabolism - other enzymes
KPYM_HUMAN	P14618	PKM	Pyruvate kinase PKM	150.7596931	255.79493	147.8462159	103.4269708	203.27731155	125.63659335	203.27731155	125.63659335	1.61797853738128	0.283182	0	0.618055170013881	0.282706	0	GO:0005929,cilium;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1903561,extracellular vesicle;GO:1904813,ficolin-1-rich granule lumen;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:1902912,pyruvate kinase complex;GO:0005791,rough endoplasmic reticulum;GO:0034774,secretory granule lumen;GO:0031982,vesicle	GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0016301,kinase activity;GO:0000287,magnesium ion binding;GO:0023026,MHC class II protein complex binding;GO:0003729,mRNA binding;GO:0030955,potassium ion binding;GO:0004743,pyruvate kinase activity;GO:0003723,RNA binding;GO:0070324,thyroid hormone binding	GO:0031100,animal organ regeneration;GO:0006754,ATP biosynthetic process;GO:0061621,canonical glycolysis;GO:0032869,cellular response to insulin stimulus;GO:0006096,glycolytic process;GO:0001889,liver development;GO:0043312,neutrophil degranulation;GO:2000767,positive regulation of cytoplasmic translation;GO:1903672,positive regulation of sprouting angiogenesis;GO:0012501,programmed cell death;GO:0042866,pyruvate biosynthetic process;GO:0009629,response to gravity;GO:0001666,response to hypoxia;GO:0014870,response to muscle inactivity;GO:0007584,response to nutrient;GO:0043403,skeletal muscle tissue regeneration	hsa:5315,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:5315,path:hsa00620,Pyruvate metabolism;hsa:5315,path:hsa00230,Purine metabolism;hsa:5315,path:hsa04922,Glucagon signaling pathway;hsa:5315,path:hsa05203,Viral carcinogenesis;hsa:5315,path:hsa05230,Central carbon metabolism in cancer;hsa:5315,path:hsa04930,Type II diabetes mellitus;hsa:5315,path:hsa05165,Human papillomavirus infection
RALY_HUMAN	Q9UKM9	RALY	RNA-binding protein Raly	4.609341735	9.146498815	3.23464437	2.759095794	6.877920275	2.996870082	6.877920275	2.996870082	2.29503451494632	0.192682	0	0.435723294568139	0.192118	0	GO:0071013,catalytic step 2 spliceosome;GO:0005634,nucleus	GO:0003723,RNA binding;GO:0003712,transcription coregulator activity	GO:0042632,cholesterol homeostasis;GO:0000398,mRNA splicing, via spliceosome;GO:1903506,regulation of nucleic acid-templated transcription	
PTBP3_HUMAN	O95758	PTBP3	Polypyrimidine tract-binding protein 3	0.443560262	0.14353239	0.351064032	0.281076438	0.293546326	0.316070235	0.293546326	0.316070235	0.928737645922274	0.457975	0	1.07673033863827	0.457832	0	GO:0005634,nucleus	GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0009653,anatomical structure morphogenesis;GO:0043249,erythrocyte maturation;GO:0006397,mRNA processing;GO:0033119,negative regulation of RNA splicing;GO:0045595,regulation of cell differentiation;GO:0043484,regulation of RNA splicing;GO:0008380,RNA splicing	
UGGG1_HUMAN	Q9NYU2	UGGT1	UDP-glucose:glycoprotein glucosyltransferase 1	7.37103534	6.122929525	11.67883601	12.23381987	6.7469824325	11.95632794	6.7469824325	11.95632794	0.564302222752515	0.284318	0	1.7721000550419	0.284617	0	GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0044322,endoplasmic reticulum quality control compartment;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0070062,extracellular exosome;GO:0032991,protein-containing complex	GO:0003980,UDP-glucose;GO:0051082,unfolded protein binding	GO:0051084,'de novo' posttranslational protein folding;GO:1904380,endoplasmic reticulum mannose trimming;GO:0071712,ER-associated misfolded protein catabolic process;GO:0018279,protein N-linked glycosylation via asparagine;GO:0006486,protein glycosylation	hsa:56886,path:hsa04141,Protein processing in endoplasmic reticulum
QSOX1_HUMAN	O00391	QSOX1	Sulfhydryl oxidase 1	0.346790964	0.351437496	0.283289122	0.812168655	0.34911423	0.5477288885	0.34911423	0.5477288885	0.637385095674025	0.350508	0	1.56891023462435	0.350756	0	GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0030173,integral component of Golgi membrane;GO:0045171,intercellular bridge;GO:0043231,intracellular membrane-bounded organelle;GO:0031093,platelet alpha granule lumen;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen	GO:0071949,FAD binding;GO:0016971,flavin-linked sulfhydryl oxidase activity;GO:0003756,protein disulfide isomerase activity	GO:0044267,cellular protein metabolic process;GO:0085029,extracellular matrix assembly;GO:0016242,negative regulation of macroautophagy;GO:0043312,neutrophil degranulation;GO:0002576,platelet degranulation;GO:0043687,post-translational protein modification;GO:0006457,protein folding	
MCES_HUMAN	O43148	RNMT	mRNA cap guanine-N7 methyltransferase	0.084454969	0.100117399	0.093299647	0.064243989	0.092286184	0.078771818	0.092286184	0.078771818	1.17156346448675	0.381590	0	0.853560246894595	0.381286	0	GO:0001650,fibrillar center;GO:0005845,mRNA cap binding complex;GO:0031533,mRNA cap methyltransferase complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0043235,receptor complex	GO:0004482,mRNA (guanine-N7-)-methyltransferase activity;GO:0003723,RNA binding	GO:0006370,7-methylguanosine mRNA capping;GO:1990830,cellular response to leukemia inhibitory factor;GO:0006366,transcription by RNA polymerase II	hsa:8731,path:hsa03015,mRNA surveillance pathway
COEA1_HUMAN	Q05707	COL14A1	Collagen alpha-1(XIV) chain	7.076251847	24.06074461	58.94843414	128.3678048	15.5684982285	93.65811947	15.5684982285	93.65811947	0.16622689326457	0.007386	-1	6.01587372753446	0.007448	1	GO:0005581,collagen trimer;GO:0005596,collagen type XIV trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005614,interstitial matrix	GO:0005518,collagen binding;GO:0005201,extracellular matrix structural constituent;GO:0030020,extracellular matrix structural constituent conferring tensile strength;GO:0030674,protein-macromolecule adaptor activity;GO:0003723,RNA binding	GO:0098609,cell-cell adhesion;GO:0030199,collagen fibril organization;GO:0030198,extracellular matrix organization	hsa:7373,path:hsa04974,Protein digestion and absorption
FADS2_HUMAN	O95864	FADS2	Acyl-CoA 6-desaturase	0.354148157	0.058569498	0.294644344	0.397039908	0.2063588275	0.345842126	0.2063588275	0.345842126	0.596685053630511	0.313913	0	1.67592600805992	0.314192	0	GO:0005789,endoplasmic reticulum membrane;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0016021,integral component of membrane	GO:0016213,linoleoyl-CoA desaturase activity;GO:0004768,stearoyl-CoA 9-desaturase activity	GO:0036109,alpha-linolenic acid metabolic process;GO:0043651,linoleic acid metabolic process;GO:0006636,unsaturated fatty acid biosynthetic process;GO:0006629,lipid metabolic process	hsa:9415,path:hsa00592,alpha-Linolenic acid metabolism;hsa:9415,path:hsa01040,Biosynthesis of unsaturated fatty acids;hsa:9415,path:hsa03320,PPAR signaling pathway
BICD2_HUMAN	Q8TD16	BICD2	Protein bicaudal D homolog 2	0.350808915	0.2649041	0.32692368	0.401750796	0.3078565075	0.364337238	0.3078565075	0.364337238	0.844976783569952	0.489680	0	1.18346446842609	0.489607	0	GO:0005642,annulate lamellae;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0005635,nuclear envelope;GO:0005643,nuclear pore;GO:0005886,plasma membrane	GO:0008093,cytoskeletal anchor activity;GO:0034452,dynactin binding;GO:0070840,dynein complex binding;GO:0051959,dynein light intermediate chain binding;GO:0031267,small GTPase binding	GO:0051642,centrosome localization;GO:0072393,microtubule anchoring at microtubule organizing center;GO:0007018,microtubule-based movement;GO:0072385,minus-end-directed organelle transport along microtubule;GO:0051028,mRNA transport;GO:0034067,protein localization to Golgi apparatus;GO:0033365,protein localization to organelle;GO:0015031,protein transport;GO:0070507,regulation of microtubule cytoskeleton organization;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	
U520_HUMAN	O75643	SNRNP200	U5 small nuclear ribonucleoprotein 200 kDa helicase	9.264062558	6.696759726	9.862834286	13.02891211	7.980411142	11.445873198	7.980411142	11.445873198	0.697230434406216	0.402530	0	1.43424605503865	0.402727	0	GO:0071013,catalytic step 2 spliceosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0071006,U2-type catalytic step 1 spliceosome;GO:0071005,U2-type precatalytic spliceosome;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005682,U5 snRNP	GO:0005524,ATP binding;GO:0004386,helicase activity;GO:0042802,identical protein binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0016787,hydrolase activity;GO:0003676,nucleic acid binding	GO:0000354,cis assembly of pre-catalytic spliceosome;GO:0000398,mRNA splicing, via spliceosome;GO:0001649,osteoblast differentiation;GO:0000388,spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	hsa:23020,path:hsa03040,Spliceosome
TM9S4_HUMAN	Q92544	TM9SF4	Transmembrane 9 superfamily member 4	2.974409431	0.854811718	3.687184732	1.855935871	1.9146105745	2.7715603015	1.9146105745	2.7715603015	0.690806032062081	0.397065	0	1.4475843486991	0.397268	0	GO:0005769,early endosome;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane;GO:0016020,membrane		GO:0007155,cell adhesion;GO:0006909,phagocytosis;GO:0070863,positive regulation of protein exit from endoplasmic reticulum;GO:2000010,positive regulation of protein localization to cell surface;GO:0072657,protein localization to membrane;GO:0051453,regulation of intracellular pH;GO:0001666,response to hypoxia;GO:0070072,vacuolar proton-transporting V-type ATPase complex assembly	
TPM2_HUMAN	P07951	TPM2	Tropomyosin beta chain	2.340323065	1.255091479	0.639976337	1.873063349	1.797707272	1.256519843	1.797707272	1.256519843	1.43070344811101	0.319273	0	0.698956867211249	0.318853	0	GO:0015629,actin cytoskeleton;GO:0005884,actin filament;GO:0005829,cytosol;GO:0005862,muscle thin filament tropomyosin;GO:0005856,cytoskeleton	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0042802,identical protein binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0008307,structural constituent of muscle	GO:0007015,actin filament organization;GO:0006936,muscle contraction;GO:0030049,muscle filament sliding;GO:0043462,regulation of ATPase activity	hsa:7169,path:hsa04260,Cardiac muscle contraction;hsa:7169,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:7169,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:7169,path:hsa05414,Dilated cardiomyopathy (DCM)
RT27_HUMAN	Q92552	MRPS27	28S ribosomal protein S27, mitochondrial	0.348093062	0.334381792	0.448688941	0.269604815	0.341237427	0.359146878	0.341237427	0.359146878	0.950133351848321	0.450367	0	1.05248384140465	0.450207	0	GO:0005737,cytoplasm;GO:0005743,mitochondrial inner membrane;GO:0005763,mitochondrial small ribosomal subunit;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005840,ribosome	GO:0097177,mitochondrial ribosome binding;GO:0019843,rRNA binding;GO:0000049,tRNA binding	GO:0008283,cell population proliferation;GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination;GO:0070131,positive regulation of mitochondrial translation	
RBM4_HUMAN	Q9BWF3	RBM4	RNA-binding protein 4	0.612014332	0.408486749	0.584050909	0.24016444	0.5102505405	0.4121076745	0.5102505405	0.4121076745	1.2381486006517	0.363958	0	0.80765749722905	0.363619	0	GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0016607,nuclear speck;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0030332,cyclin binding;GO:0035198,miRNA binding;GO:0003730,mRNA 3'-UTR binding;GO:0003729,mRNA binding;GO:0097157,pre-mRNA intronic binding;GO:0097158,pre-mRNA intronic pyrimidine-rich binding;GO:0003723,RNA binding;GO:0008270,zinc ion binding	GO:0002190,cap-independent translational initiation;GO:0030154,cell differentiation;GO:0097167,circadian regulation of translation;GO:0043153,entrainment of circadian clock by photoperiod;GO:0002192,IRES-dependent translational initiation of linear mRNA;GO:0035278,miRNA mediated inhibition of translation;GO:0000398,mRNA splicing, via spliceosome;GO:0017148,negative regulation of translation;GO:0032055,negative regulation of translation in response to stress;GO:0045947,negative regulation of translational initiation;GO:0051149,positive regulation of muscle cell differentiation;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0046822,regulation of nucleocytoplasmic transport;GO:0046685,response to arsenic-containing substance;GO:0006396,RNA processing;GO:0006397,mRNA processing;GO:0008380,RNA splicing	
EFHD2_HUMAN	Q96C19	EFHD2	EF-hand domain-containing protein D2	2.623052132	4.428159401	1.383334147	0.557128561	3.5256057665	0.970231354	3.5256057665	0.970231354	3.63377843023201	0.104672	0	0.27519564530415	0.104141	0	GO:0045121,membrane raft	GO:0045296,cadherin binding;GO:0005509,calcium ion binding		
RMXL1_HUMAN	Q96E39	RBMXL1	RNA binding motif protein, X-linked-like-1	0.056783946	0.027312023	0.099898906	2.55E-05	0.0420479845	0.049962203	0.0420479845	0.049962203	0.841595885994058	0.491028	0	1.18821873614418	0.490957	0	GO:0005681,spliceosomal complex	GO:0003723,RNA binding	GO:0006397,mRNA processing;GO:0048026,positive regulation of mRNA splicing, via spliceosome;GO:0008380,RNA splicing	hsa:494115,path:hsa03040,Spliceosome
MVD1_HUMAN	P53602	MVD	Diphosphomevalonate decarboxylase	0.492294642	0.158240121	0.319504849	0.134559634	0.3252673815	0.2270322415	0.3252673815	0.2270322415	1.43269246407894	0.318854	0	0.697986500991954	0.318434	0	GO:0005829,cytosol	GO:0005524,ATP binding;GO:0004163,diphosphomevalonate decarboxylase activity;GO:0030544,Hsp70 protein binding;GO:0042803,protein homodimerization activity;GO:0016831,carboxy-lyase activity	GO:0006695,cholesterol biosynthetic process;GO:0006489,dolichyl diphosphate biosynthetic process;GO:0019287,isopentenyl diphosphate biosynthetic process, mevalonate pathway;GO:0008299,isoprenoid biosynthetic process;GO:0008284,positive regulation of cell population proliferation;GO:0019216,regulation of lipid metabolic process	hsa:4597,path:hsa00900,Terpenoid backbone biosynthesis
TM41B_HUMAN	Q5BJD5	TMEM41B	Transmembrane protein 41B	0.071129919	0.088369049	0.123025569	2.55E-05	0.079749484	0.0615255345	0.079749484	0.0615255345	1.29620140073712	0.349556	0	0.771485048103885	0.349190	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0044233,mitochondria-associated endoplasmic reticulum membrane		GO:0000045,autophagosome assembly;GO:0007399,nervous system development	
ECHP_HUMAN	Q08426	EHHADH	Peroxisomal bifunctional enzyme	0.241167198	0.336771593	0.501190733	0.20080389	0.2889693955	0.3509973115	0.2889693955	0.3509973115	0.823280937010824	0.498425	0	1.21465219835019	0.498372	0	GO:0005829,cytosol;GO:0005782,peroxisomal matrix;GO:0005777,peroxisome	GO:0003857,3-hydroxyacyl-CoA dehydrogenase activity;GO:0004165,dodecenoyl-CoA delta-isomerase activity;GO:0004300,enoyl-CoA hydratase activity;GO:0019899,enzyme binding;GO:0016863,intramolecular oxidoreductase activity, transposing C=C bonds;GO:0016509,long-chain-3-hydroxyacyl-CoA dehydrogenase activity;GO:0070403,NAD+ binding;GO:0003824,catalytic activity	GO:0006635,fatty acid beta-oxidation;GO:0033540,fatty acid beta-oxidation using acyl-CoA oxidase;GO:0008104,protein localization	hsa:1962,path:hsa00640,Propanoate metabolism;hsa:1962,path:hsa00650,Butanoate metabolism;hsa:1962,path:hsa00071,Fatty acid degradation;hsa:1962,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:1962,path:hsa00310,Lysine degradation;hsa:1962,path:hsa00380,Tryptophan metabolism;hsa:1962,path:hsa00410,beta-Alanine metabolism;hsa:1962,path:hsa04146,Peroxisome;hsa:1962,path:hsa03320,PPAR signaling pathway
GNAI3_HUMAN	P08754	GNAI3	Guanine nucleotide-binding protein G(i) subunit alpha-3	1.141764486	1.124038673	1.43957677	2.032824976	1.1329015795	1.736200873	1.1329015795	1.736200873	0.652517572775117	0.363886	0	1.53252577665772	0.364121	0	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0005834,heterotrimeric G-protein complex;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0045121,membrane raft;GO:0030496,midbody;GO:0005886,plasma membrane;GO:0042588,zymogen granule	GO:0001664,G protein-coupled receptor binding;GO:0031821,G protein-coupled serotonin receptor binding;GO:0031683,G-protein beta/gamma-subunit complex binding;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0032794,GTPase activating protein binding;GO:0003924,GTPase activity;GO:0046872,metal ion binding;GO:0019904,protein domain specific binding	GO:0007193,adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007188,adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007420,brain development;GO:0007049,cell cycle;GO:0051301,cell division;GO:0007212,dopamine receptor signaling pathway;GO:0007186,G protein-coupled receptor signaling pathway;GO:0046039,GTP metabolic process;GO:0007194,negative regulation of adenylate cyclase activity;GO:2001234,negative regulation of apoptotic signaling pathway;GO:0030168,platelet activation;GO:0016239,positive regulation of macroautophagy;GO:0033864,positive regulation of NAD(P)H oxidase activity;GO:0032930,positive regulation of superoxide anion generation;GO:1904707,positive regulation of vascular associated smooth muscle cell proliferation;GO:0006457,protein folding;GO:0006906,vesicle fusion	hsa:2773,path:hsa04015,Rap1 signaling pathway;hsa:2773,path:hsa04371,Apelin signaling pathway;hsa:2773,path:hsa04071,Sphingolipid signaling pathway;hsa:2773,path:hsa04024,cAMP signaling pathway;hsa:2773,path:hsa04022,cGMP-PKG signaling pathway;hsa:2773,path:hsa04540,Gap junction;hsa:2773,path:hsa04611,Platelet activation;hsa:2773,path:hsa04670,Leukocyte transendothelial migration;hsa:2773,path:hsa04062,Chemokine signaling pathway;hsa:2773,path:hsa04923,Regulation of lipolysis in adipocytes;hsa:2773,path:hsa04915,Estrogen signaling pathway;hsa:2773,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:2773,path:hsa04921,Oxytocin signaling pathway;hsa:2773,path:hsa04926,Relaxin signaling pathway;hsa:2773,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:2773,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:2773,path:hsa04916,Melanogenesis;hsa:2773,path:hsa04924,Renin secretion;hsa:2773,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:2773,path:hsa04971,Gastric acid secretion;hsa:2773,path:hsa04724,Glutamatergic synapse;hsa:2773,path:hsa04727,GABAergic synapse;hsa:2773,path:hsa04725,Cholinergic synapse;hsa:2773,path:hsa04728,Dopaminergic synapse;hsa:2773,path:hsa04726,Serotonergic synapse;hsa:2773,path:hsa04730,Long-term depression;hsa:2773,path:hsa04723,Retrograde endocannabinoid signaling;hsa:2773,path:hsa04360,Axon guidance;hsa:2773,path:hsa04713,Circadian entrainment;hsa:2773,path:hsa05200,Pathways in cancer;hsa:2773,path:hsa05012,Parkinson disease;hsa:2773,path:hsa05030,Cocaine addiction;hsa:2773,path:hsa05032,Morphine addiction;hsa:2773,path:hsa05034,Alcoholism;hsa:2773,path:hsa04934,Cushing syndrome;hsa:2773,path:hsa05133,Pertussis;hsa:2773,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:2773,path:hsa05163,Human cytomegalovirus infection;hsa:2773,path:hsa05145,Toxoplasmosis;hsa:2773,path:hsa05142,Chagas disease (American trypanosomiasis)
PUF60_HUMAN	Q9UHX1	PUF60	Poly(U)-binding-splicing factor PUF60	2.331539835	0.802949465	2.824857656	1.545267284	1.56724465	2.18506247	1.56724465	2.18506247	0.717253932790306	0.419359	0	1.39420636720629	0.419539	0	GO:0030054,cell junction;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0045296,cadherin binding;GO:0003677,DNA binding;GO:0042802,identical protein binding;GO:0003723,RNA binding	GO:0000380,alternative mRNA splicing, via spliceosome;GO:0006915,apoptotic process;GO:0006376,mRNA splice site selection;GO:0000398,mRNA splicing, via spliceosome;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0006397,mRNA processing;GO:0008380,RNA splicing	hsa:22827,path:hsa03040,Spliceosome
DDX46_HUMAN	Q7L014	DDX46	Probable ATP-dependent RNA helicase DDX46	1.667827301	1.30650148	1.612178486	1.961190934	1.4871643905	1.78668471	1.4871643905	1.78668471	0.832359723109737	0.494738	0	1.20140363863829	0.494676	0	GO:0015030,Cajal body;GO:0001650,fibrillar center;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0016787,hydrolase activity;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0003676,nucleic acid binding	GO:0000398,mRNA splicing, via spliceosome	hsa:9879,path:hsa03040,Spliceosome
PAPS2_HUMAN	O95340	PAPSS2	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2	1.601871443	1.003430654	1.305727831	1.735758746	1.3026510485	1.5207432885	1.3026510485	1.5207432885	0.856588392236064	0.485093	0	1.1674218435176	0.485010	0	GO:0005829,cytosol	GO:0004020,adenylylsulfate kinase activity;GO:0005524,ATP binding;GO:0016779,nucleotidyltransferase activity;GO:0004781,sulfate adenylyltransferase (ATP) activity	GO:0050428,3'-phosphoadenosine 5'-phosphosulfate biosynthetic process;GO:0001501,skeletal system development;GO:0000103,sulfate assimilation	hsa:9060,path:hsa00920,Sulfur metabolism;hsa:9060,path:hsa00230,Purine metabolism;hsa:9060,path:hsa00450,Selenocompound metabolism
COG1_HUMAN	Q8WTW3	COG1	Conserved oligomeric Golgi complex subunit 1	0.121202241	0.064987144	0.312930771	0.050603213	0.0930946925	0.181766992	0.0930946925	0.181766992	0.512165005734375	0.236313	0	1.95249575586707	0.236638	0	GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0017119,Golgi transport complex;GO:0032588,trans-Golgi network membrane;GO:0016020,membrane		GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030,Golgi organization;GO:0006891,intra-Golgi vesicle-mediated transport;GO:0015031,protein transport	
GPX1_HUMAN	P07203	GPX1	Glutathione peroxidase 1	3.632948744	18.8295317	1.086065265	0.681131183	11.231240222	0.883598224	11.231240222	0.883598224	12.7107999053651	0.010422	1	0.0786732548262291	0.010277	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0004602,glutathione peroxidase activity;GO:0004601,peroxidase activity;GO:0047066,phospholipid-hydroperoxide glutathione peroxidase activity;GO:0017124,SH3 domain binding	GO:0060055,angiogenesis involved in wound healing;GO:0019369,arachidonic acid metabolic process;GO:0051702,biological process involved in interaction with symbiont;GO:0043534,blood vessel endothelial cell migration;GO:0045454,cell redox homeostasis;GO:0034599,cellular response to oxidative stress;GO:0001885,endothelial cell development;GO:0045444,fat cell differentiation;GO:0006749,glutathione metabolic process;GO:0060047,heart contraction;GO:0042744,hydrogen peroxide catabolic process;GO:0019372,lipoxygenase pathway;GO:0051450,myoblast proliferation;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:1902042,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:1902176,negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:0090201,negative regulation of release of cytochrome c from mitochondria;GO:0051897,positive regulation of protein kinase B signaling;GO:1902905,positive regulation of supramolecular fiber organization;GO:0018158,protein oxidation;GO:0006195,purine nucleotide catabolic process;GO:0040029,regulation of gene expression, epigenetic;GO:0033599,regulation of mammary gland epithelial cell proliferation;GO:0061136,regulation of proteasomal protein catabolic process;GO:0010332,response to gamma radiation;GO:0042542,response to hydrogen peroxide;GO:0033194,response to hydroperoxide;GO:0010269,response to selenium ion;GO:0009609,response to symbiotic bacterium;GO:0009410,response to xenobiotic stimulus;GO:0007605,sensory perception of sound;GO:0048741,skeletal muscle fiber development;GO:0043403,skeletal muscle tissue regeneration;GO:0001659,temperature homeostasis;GO:0006641,triglyceride metabolic process;GO:0009650,UV protection;GO:0042311,vasodilation;GO:0006979,response to oxidative stress	hsa:2876,path:hsa00590,Arachidonic acid metabolism;hsa:2876,path:hsa00480,Glutathione metabolism;hsa:2876,path:hsa04918,Thyroid hormone synthesis;hsa:2876,path:hsa05014,Amyotrophic lateral sclerosis (ALS);hsa:2876,path:hsa05016,Huntington disease
WFS1_HUMAN	O76024	WFS1	Wolframin	0.212001039	0.191487578	0.307484702	1.105241952	0.2017443085	0.706363327	0.2017443085	0.706363327	0.285609828240701	0.053620	0	3.50128007204724	0.053847	0	GO:0030425,dendrite;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0030285,integral component of synaptic vesicle membrane;GO:0016021,integral component of membrane	GO:0051117,ATPase binding;GO:0031625,ubiquitin protein ligase binding;GO:0033613,activating transcription factor binding;GO:0048306,calcium-dependent protein binding;GO:0005516,calmodulin binding;GO:0070628,proteasome binding	GO:0055074,calcium ion homeostasis;GO:0044267,cellular protein metabolic process;GO:0032469,endoplasmic reticulum calcium ion homeostasis;GO:0030968,endoplasmic reticulum unfolded protein response;GO:0006983,ER overload response;GO:0042593,glucose homeostasis;GO:0036498,IRE1-mediated unfolded protein response;GO:0001822,kidney development;GO:1903892,negative regulation of ATF6-mediated unfolded protein response;GO:0043433,negative regulation of DNA-binding transcription factor activity;GO:0043524,negative regulation of neuron apoptotic process;GO:0043069,negative regulation of programmed cell death;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:2000675,negative regulation of type B pancreatic cell apoptotic process;GO:0050877,nervous system process;GO:0051928,positive regulation of calcium ion transport;GO:0045927,positive regulation of growth;GO:0051247,positive regulation of protein metabolic process;GO:0031398,positive regulation of protein ubiquitination;GO:0043687,post-translational protein modification;GO:0022417,protein maturation by protein folding;GO:0050821,protein stabilization;GO:0003091,renal water homeostasis;GO:0034976,response to endoplasmic reticulum stress;GO:0007605,sensory perception of sound;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0007601,visual perception;GO:1902236,negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0042048,olfactory behavior;GO:0031016,pancreas development	hsa:7466,path:hsa04141,Protein processing in endoplasmic reticulum
MA2B1_HUMAN	O00754	MAN2B1	Lysosomal alpha-mannosidase	0.373812147	0.775428767	0.460570738	0.830514412	0.574620457	0.645542575	0.574620457	0.645542575	0.890135645971917	0.472194	0	1.12342428316993	0.472082	0	GO:0035578,azurophil granule lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043231,intracellular membrane-bounded organelle;GO:0043202,lysosomal lumen;GO:0005764,lysosome;GO:0005654,nucleoplasm;GO:0005774,vacuolar membrane	GO:0004559,alpha-mannosidase activity;GO:0030246,carbohydrate binding;GO:0046872,metal ion binding;GO:0003824,catalytic activity	GO:0006464,cellular protein modification process;GO:0006013,mannose metabolic process;GO:0043312,neutrophil degranulation;GO:0009313,oligosaccharide catabolic process;GO:0006517,protein deglycosylation;GO:0005975,carbohydrate metabolic process	hsa:4125,path:hsa00511,Other glycan degradation;hsa:4125,path:hsa04142,Lysosome
VASP_HUMAN	P50552	VASP	Vasodilator-stimulated phosphoprotein	1.200906408	2.611065592	1.242211399	1.356839939	1.905986	1.299525669	1.905986	1.299525669	1.4666782238066	0.311832	0	0.681812809223153	0.311400	0	GO:0015629,actin cytoskeleton;GO:0005923,bicellular tight junction;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0031527,filopodium membrane;GO:0005925,focal adhesion;GO:0031258,lamellipodium membrane;GO:0005886,plasma membrane	GO:0003779,actin binding;GO:0045296,cadherin binding;GO:0005522,profilin binding;GO:0017124,SH3 domain binding	GO:0030036,actin cytoskeleton organization;GO:0008154,actin polymerization or depolymerization;GO:0007411,axon guidance;GO:0034329,cell junction assembly;GO:0001843,neural tube closure;GO:0030838,positive regulation of actin filament polymerization;GO:0051289,protein homotetramerization	hsa:7408,path:hsa04015,Rap1 signaling pathway;hsa:7408,path:hsa04022,cGMP-PKG signaling pathway;hsa:7408,path:hsa04510,Focal adhesion;hsa:7408,path:hsa04530,Tight junction;hsa:7408,path:hsa04611,Platelet activation;hsa:7408,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:7408,path:hsa04670,Leukocyte transendothelial migration
POTEI_HUMAN	P0CG38	POTEI	POTE ankyrin domain family member I	5.479281592	3.976089767	6.443322127	7.693058409	4.7276856795	7.068190268	4.7276856795	7.068190268	0.668867913885082	0.378178	0	1.49506349346548	0.378400	0	GO:0070062,extracellular exosome;GO:0005615,extracellular space		GO:0001895,retina homeostasis	
OAS3_HUMAN	Q9Y6K5	OAS3	2'-5'-oligoadenylate synthase 3	1.166197961	1.825367545	1.576301191	0.796111142	1.495782753	1.1862061665	1.495782753	1.1862061665	1.26098042249555	0.358190	0	0.793033723728194	0.357841	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005615,extracellular space;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0001730,2'-5'-oligoadenylate synthetase activity;GO:0005524,ATP binding;GO:0003725,double-stranded RNA binding;GO:0046872,metal ion binding	GO:0042742,defense response to bacterium;GO:0051607,defense response to virus;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0039530,MDA-5 signaling pathway;GO:0071650,negative regulation of chemokine (C-C motif) ligand 5 production;GO:2000342,negative regulation of chemokine (C-X-C motif) ligand 2 production;GO:0035395,negative regulation of chemokine (C-X-C motif) ligand 9 production;GO:0071659,negative regulation of IP-10 production;GO:0060339,negative regulation of type I interferon-mediated signaling pathway;GO:0045071,negative regulation of viral genome replication;GO:0006139,nucleobase-containing compound metabolic process;GO:0032728,positive regulation of interferon-beta production;GO:0071639,positive regulation of monocyte chemotactic protein-1 production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0060700,regulation of ribonuclease activity;GO:0009615,response to virus;GO:0039529,RIG-I signaling pathway;GO:0060337,type I interferon signaling pathway	hsa:4940,path:hsa04621,NOD-like receptor signaling pathway;hsa:4940,path:hsa05162,Measles;hsa:4940,path:hsa05164,Influenza A;hsa:4940,path:hsa05160,Hepatitis C;hsa:4940,path:hsa05168,Herpes simplex virus 1 infection;hsa:4940,path:hsa05169,Epstein-Barr virus infection
PERE_HUMAN	P11678	EPX	Eosinophil peroxidase	1.660470116	3.245761029	1.882127743	3.830812031	2.4531155725	2.856469887	2.4531155725	2.856469887	0.858792730028174	0.484229	0	1.16442532060931	0.484144	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0034774,secretory granule lumen	GO:0020037,heme binding;GO:0046872,metal ion binding;GO:0004601,peroxidase activity	GO:0042742,defense response to bacterium;GO:0002215,defense response to nematode;GO:0072677,eosinophil migration;GO:0042744,hydrogen peroxide catabolic process;GO:0032693,negative regulation of interleukin-10 production;GO:0032714,negative regulation of interleukin-5 production;GO:0043312,neutrophil degranulation;GO:0032753,positive regulation of interleukin-4 production;GO:0006979,response to oxidative stress	hsa:8288,path:hsa05310,Asthma
SPTC2_HUMAN	O15270	SPTLC2	Serine palmitoyltransferase 2	0.045530801	0.049410203	0.108542407	0.062471096	0.047470502	0.0855067515	0.047470502	0.0855067515	0.555166711016966	0.275920	0	1.80126073872149	0.276225	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0017059,serine C-palmitoyltransferase complex	GO:0030170,pyridoxal phosphate binding;GO:0004758,serine C-palmitoyltransferase activity;GO:0016740,transferase activity	GO:0060612,adipose tissue development;GO:0046513,ceramide biosynthetic process;GO:1904504,positive regulation of lipophagy;GO:0046511,sphinganine biosynthetic process;GO:0030148,sphingolipid biosynthetic process;GO:0006686,sphingomyelin biosynthetic process;GO:0046512,sphingosine biosynthetic process;GO:0009058,biosynthetic process	hsa:9517,path:hsa00600,Sphingolipid metabolism;hsa:9517,path:hsa04071,Sphingolipid signaling pathway
ACON_HUMAN	Q99798	ACO2	Aconitate hydratase, mitochondrial	9.007219533	9.801330681	17.50560976	13.04785095	9.404275107	15.276730355	9.404275107	15.276730355	0.61559475676168	0.331016	0	1.62444528485017	0.331281	0	GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0051539,4 iron, 4 sulfur cluster binding;GO:0003994,aconitate hydratase activity;GO:0047780,citrate dehydratase activity;GO:0005506,iron ion binding;GO:0051538,3 iron, 4 sulfur cluster binding;GO:0046872,metal ion binding	GO:0006101,citrate metabolic process;GO:0006091,generation of precursor metabolites and energy;GO:0006099,tricarboxylic acid cycle;GO:0006102,isocitrate metabolic process;GO:0001889,liver development;GO:0035900,response to isolation stress	hsa:50,path:hsa00020,Citrate cycle (TCA cycle);hsa:50,path:hsa00630,Glyoxylate and dicarboxylate metabolism
SERPH_HUMAN	P50454	SERPINH1	Serpin H1	46.48406153	89.24264065	58.78508001	27.25214609	67.86335109	43.01861305	67.86335109	43.01861305	1.57753461300864	0.290447	0	0.633900512707499	0.289982	0	GO:0062023,collagen-containing extracellular matrix;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0005615,extracellular space;GO:0045121,membrane raft	GO:0005518,collagen binding;GO:0003723,RNA binding;GO:0004867,serine-type endopeptidase inhibitor activity;GO:0051082,unfolded protein binding	GO:0003433,chondrocyte development involved in endochondral bone morphogenesis;GO:0032964,collagen biosynthetic process;GO:0030199,collagen fibril organization;GO:0010951,negative regulation of endopeptidase activity;GO:0051604,protein maturation;GO:0006986,response to unfolded protein	
GDIB_HUMAN	P50395	GDI2	Rab GDP dissociation inhibitor beta	20.51951803	25.73685226	37.85295851	26.90463245	23.128185145	32.37879548	23.128185145	32.37879548	0.714300356209545	0.416896	0	1.39997130241756	0.417079	0	GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0034774,secretory granule lumen;GO:0045202,synapse;GO:0031982,vesicle	GO:0005096,GTPase activator activity;GO:0005093,Rab GDP-dissociation inhibitor activity;GO:0003723,RNA binding;GO:0031267,small GTPase binding	GO:0043312,neutrophil degranulation;GO:0043547,positive regulation of GTPase activity;GO:0015031,protein transport;GO:0007165,signal transduction;GO:0007264,small GTPase mediated signal transduction;GO:0016192,vesicle-mediated transport	
IGJ_HUMAN	P01591	JCHAIN	Immunoglobulin J chain	0.43271592	0.117509517	0.473571055	0.790944752	0.2751127185	0.6322579035	0.2751127185	0.6322579035	0.435127369665218	0.166691	0	2.29817765949632	0.167026	0	GO:0072562,blood microparticle;GO:0071750,dimeric IgA immunoglobulin complex;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0071748,monomeric IgA immunoglobulin complex;GO:0071756,pentameric IgM immunoglobulin complex;GO:0071752,secretory dimeric IgA immunoglobulin complex;GO:0071751,secretory IgA immunoglobulin complex	GO:0003823,antigen binding;GO:0019862,IgA binding;GO:0034987,immunoglobulin receptor binding;GO:0042803,protein homodimerization activity;GO:0030674,protein-macromolecule adaptor activity	GO:0002250,adaptive immune response;GO:0019731,antibacterial humoral response;GO:0003094,glomerular filtration;GO:0006959,humoral immune response;GO:0006955,immune response;GO:0045087,innate immune response;GO:0050900,leukocyte migration;GO:0060267,positive regulation of respiratory burst;GO:0065003,protein-containing complex assembly;GO:0006898,receptor-mediated endocytosis;GO:0001895,retina homeostasis	
SUN2_HUMAN	Q9UH99	SUN2	SUN domain-containing protein 2	1.585617194	1.15545189	2.045282187	4.78903353	1.370534542	3.4171578585	1.370534542	3.4171578585	0.401074401228163	0.137447	0	2.49330298053881	0.137773	0	GO:0000781,chromosome, telomeric region;GO:0000794,condensed nuclear chromosome;GO:0010008,endosome membrane;GO:0005639,integral component of nuclear inner membrane;GO:0034993,meiotic nuclear membrane microtubule tethering complex;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane	GO:0140444,cytoskeleton-nuclear membrane anchor activity;GO:0042802,identical protein binding;GO:0005521,lamin binding;GO:0008017,microtubule binding;GO:0043495,protein-membrane adaptor activity	GO:0051642,centrosome localization;GO:0051321,meiotic cell cycle;GO:0007052,mitotic spindle organization;GO:0006998,nuclear envelope organization;GO:0090292,nuclear matrix anchoring at nuclear membrane;GO:0007097,nuclear migration;GO:0031022,nuclear migration along microfilament;GO:0021817,nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration;GO:0030335,positive regulation of cell migration	
KAIN_HUMAN	P29622	SERPINA4	Kallistatin	0.796850122	0.579570782	1.043178192	1.94624751	0.688210452	1.494712851	0.688210452	1.494712851	0.460429875570796	0.189174	0	2.17188339214587	0.189509	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0031089,platelet dense granule lumen	GO:0004867,serine-type endopeptidase inhibitor activity	GO:0010951,negative regulation of endopeptidase activity;GO:0002576,platelet degranulation	
DX39B_HUMAN	Q13838	DDX39B	Spliceosome RNA helicase DDX39B	11.37705719	7.878056889	17.37353044	10.96046369	9.6275570395	14.166997065	9.6275570395	14.166997065	0.679576412370775	0.387440	0	1.47150486949862	0.387653	0	GO:0005737,cytoplasm;GO:0016363,nuclear matrix;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0000346,transcription export complex	GO:0005524,ATP binding;GO:0043008,ATP-dependent protein binding;GO:0016887,ATPase activity;GO:0008186,ATPase activity, acting on RNA;GO:0042802,identical protein binding;GO:0044877,protein-containing complex binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0030621,U4 snRNA binding;GO:0017070,U6 snRNA binding;GO:0016787,hydrolase activity;GO:0003676,nucleic acid binding	GO:0001889,liver development;GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:2000002,negative regulation of DNA damage checkpoint;GO:0061051,positive regulation of cell growth involved in cardiac muscle cell development;GO:2000573,positive regulation of DNA biosynthetic process;GO:0032786,positive regulation of DNA-templated transcription, elongation;GO:0045727,positive regulation of translation;GO:1904707,positive regulation of vascular associated smooth muscle cell proliferation;GO:0006405,RNA export from nucleus;GO:0010501,RNA secondary structure unwinding;GO:0008380,RNA splicing;GO:0000245,spliceosomal complex assembly;GO:0046784,viral mRNA export from host cell nucleus	hsa:7919,path:hsa03040,Spliceosome;hsa:7919,path:hsa03013,RNA transport;hsa:7919,path:hsa03015,mRNA surveillance pathway
RAB38_HUMAN	P57729	RAB38	Ras-related protein Rab-38	0.109654531	0.333743294	0.008757674	0.002212654	0.2216989125	0.005485164	0.2216989125	0.005485164	40.4179186802801	0.000508	1	0.0247415016075011	0.000495	-1	GO:0005829,cytosol;GO:0005769,early endosome;GO:0012505,endomembrane system;GO:0005783,endoplasmic reticulum;GO:0005764,lysosome;GO:0042470,melanosome;GO:0033162,melanosome membrane;GO:0016020,membrane;GO:0044233,mitochondria-associated endoplasmic reticulum membrane;GO:0005739,mitochondrion;GO:0045335,phagocytic vesicle;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0005802,trans-Golgi network;GO:0031982,vesicle	GO:0035650,AP-1 adaptor complex binding;GO:0035651,AP-3 adaptor complex binding;GO:0036461,BLOC-2 complex binding;GO:0005525,GTP binding;GO:0030742,GTP-dependent protein binding;GO:0003924,GTPase activity	GO:0035646,endosome to melanosome transport;GO:0006886,intracellular protein transport;GO:1903232,melanosome assembly;GO:0032438,melanosome organization;GO:0007005,mitochondrion organization;GO:0090383,phagosome acidification;GO:0060155,platelet dense granule organization;GO:2001247,positive regulation of phosphatidylcholine biosynthetic process;GO:0043687,post-translational protein modification;GO:0072657,protein localization to membrane;GO:0015031,protein transport;GO:0007264,small GTPase mediated signal transduction;GO:0016192,vesicle-mediated transport	
TBB4B_HUMAN	P68371	TUBB4B	Tubulin beta-4B chain	102.0033723	171.2234393	148.4972336	110.963428	136.6134058	129.7303308	136.6134058	129.7303308	1.05305679063296	0.416279	0	0.949616401408829	0.416046	0	GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1903561,extracellular vesicle;GO:0005874,microtubule;GO:0005634,nucleus	GO:0003725,double-stranded RNA binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042288,MHC class I protein binding;GO:0005200,structural constituent of cytoskeleton;GO:0051082,unfolded protein binding	GO:0097711,ciliary basal body-plasma membrane docking;GO:0000086,G2/M transition of mitotic cell cycle;GO:0000226,microtubule cytoskeleton organization;GO:0000278,mitotic cell cycle;GO:0042267,natural killer cell mediated cytotoxicity;GO:0043312,neutrophil degranulation;GO:0010389,regulation of G2/M transition of mitotic cell cycle	hsa:10383,path:hsa04145,Phagosome;hsa:10383,path:hsa04540,Gap junction;hsa:10383,path:hsa05130,Pathogenic Escherichia coli infection
NSF1C_HUMAN	Q9UNZ2	NSFL1C	NSFL1 cofactor p47	0.842159912	1.017452989	1.326008699	2.077484072	0.9298064505	1.7017463855	0.9298064505	1.7017463855	0.546383678803471	0.267835	0	1.83021572348191	0.268144	0	GO:0005694,chromosome;GO:0005829,cytosol;GO:0005795,Golgi stack;GO:0045111,intermediate filament cytoskeleton;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0031616,spindle pole centrosome;GO:1990730,VCP-NSFL1C complex	GO:0051117,ATPase binding;GO:0005543,phospholipid binding;GO:0043130,ubiquitin binding	GO:0000045,autophagosome assembly;GO:0000132,establishment of mitotic spindle orientation;GO:0007030,Golgi organization;GO:0061025,membrane fusion;GO:1904780,negative regulation of protein localization to centrosome;GO:0031468,nuclear envelope reassembly;GO:0046604,positive regulation of mitotic centrosome separation;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process	hsa:55968,path:hsa04141,Protein processing in endoplasmic reticulum
NDUA9_HUMAN	Q16795	NDUFA9	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	2.329152679	1.244855864	4.59482015	1.684434748	1.7870042715	3.139627449	1.7870042715	3.139627449	0.569177171663847	0.288792	0	1.75692218483877	0.289089	0	GO:0005759,mitochondrial matrix;GO:0031966,mitochondrial membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0008137,NADH dehydrogenase (ubiquinone) activity;GO:0003954,NADH dehydrogenase activity;GO:0044877,protein-containing complex binding	GO:0007623,circadian rhythm;GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0009749,response to glucose;GO:0006814,sodium ion transport;GO:1901006,ubiquinone-6 biosynthetic process	hsa:4704,path:hsa00190,Oxidative phosphorylation;hsa:4704,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4704,path:hsa04714,Thermogenesis;hsa:4704,path:hsa05010,Alzheimer disease;hsa:4704,path:hsa05012,Parkinson disease;hsa:4704,path:hsa05016,Huntington disease;hsa:4704,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
PARP9_HUMAN	Q8IXQ6	PARP9	Protein mono-ADP-ribosyltransferase PARP9	0.332809657	0.795641983	0.803516953	0.556888859	0.56422582	0.680202906	0.56422582	0.680202906	0.829496338552838	0.495896	0	1.20555083069399	0.495837	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0090734,site of DNA damage	GO:0072570,ADP-D-ribose binding;GO:0019899,enzyme binding;GO:0004857,enzyme inhibitor activity;GO:0042393,histone binding;GO:0003950,NAD+ ADP-ribosyltransferase activity;GO:1990404,protein ADP-ribosylase activity;GO:0097677,STAT family protein binding;GO:0003714,transcription corepressor activity;GO:0044389,ubiquitin-like protein ligase binding	GO:0016477,cell migration;GO:0051607,defense response to virus;GO:0006302,double-strand break repair;GO:0045087,innate immune response;GO:0034356,NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0043086,negative regulation of catalytic activity;GO:0010629,negative regulation of gene expression;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0035563,positive regulation of chromatin binding;GO:0002230,positive regulation of defense response to virus by host;GO:2001034,positive regulation of double-strand break repair via nonhomologous end joining;GO:0060335,positive regulation of interferon-gamma-mediated signaling pathway;GO:1900182,positive regulation of protein localization to nucleus;GO:0045893,positive regulation of transcription, DNA-templated;GO:0042531,positive regulation of tyrosine phosphorylation of STAT protein;GO:0010608,posttranscriptional regulation of gene expression;GO:0006471,protein ADP-ribosylation;GO:0140289,protein mono-ADP-ribosylation;GO:0060330,regulation of response to interferon-gamma;GO:0019082,viral protein processing	
LV208_HUMAN	P01709	IGLV2-8	Immunoglobulin lambda variable 2-8	0.223626317	0.084707137	0.326151116	0.378835047	0.154166727	0.3524930815	0.154166727	0.3524930815	0.437361001083932	0.168654	0	2.28644071492807	0.168989	0	GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0070062,extracellular exosome	GO:0003823,antigen binding	GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
NPC2_HUMAN	P61916	NPC2	NPC intracellular cholesterol transporter 2	1.635697358	10.00559133	0.427832916	0.073345806	5.820644344	0.250589361	5.820644344	0.250589361	23.2278190932455	0.002409	1	0.0430518248822935	0.002361	-1	GO:0035578,azurophil granule lumen;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043202,lysosomal lumen;GO:0005764,lysosome	GO:0015485,cholesterol binding;GO:0120020,cholesterol transfer activity;GO:0019899,enzyme binding;GO:0032934,sterol binding	GO:0033344,cholesterol efflux;GO:0042632,cholesterol homeostasis;GO:0008203,cholesterol metabolic process;GO:0030301,cholesterol transport;GO:0046836,glycolipid transport;GO:0032367,intracellular cholesterol transport;GO:0032366,intracellular sterol transport;GO:0034383,low-density lipoprotein particle clearance;GO:0043312,neutrophil degranulation;GO:0015914,phospholipid transport;GO:0019747,regulation of isoprenoid metabolic process;GO:0009615,response to virus;GO:0015918,sterol transport	hsa:10577,path:hsa04142,Lysosome;hsa:10577,path:hsa04979,Cholesterol metabolism
ACBP_HUMAN	P07108	DBI	Acyl-CoA-binding protein	0.563086013	0.259809109	0.434482461	1.124051853	0.411447561	0.779267157	0.411447561	0.779267157	0.527992944786713	0.250888	0	1.89396470137297	0.251206	0	GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0097038,perinuclear endoplasmic reticulum;GO:0032994,protein-lipid complex	GO:0030156,benzodiazepine receptor binding;GO:0042802,identical protein binding;GO:0008289,lipid binding;GO:0036042,long-chain fatty acyl-CoA binding;GO:0000062,fatty-acyl-CoA binding	GO:0006637,acyl-CoA metabolic process;GO:1903060,negative regulation of protein lipidation;GO:0036151,phosphatidylcholine acyl-chain remodeling;GO:1905920,positive regulation of CoA-transferase activity;GO:2001140,positive regulation of phospholipid transport	hsa:1622,path:hsa03320,PPAR signaling pathway
TPMT_HUMAN	P51580	TPMT	Thiopurine S-methyltransferase	0.457400659	1.026413405	0.296845942	0.344833084	0.741907032	0.320839513	0.741907032	0.320839513	2.31239296264609	0.190948	0	0.432452449109554	0.190383	0	GO:0005829,cytosol	GO:1904047,S-adenosyl-L-methionine binding;GO:0008119,thiopurine S-methyltransferase activity	GO:0017144,drug metabolic process;GO:0032259,methylation;GO:0006139,nucleobase-containing compound metabolic process	hsa:7172,path:hsa00983,Drug metabolism - other enzymes
SFXN3_HUMAN	Q9BWM7	SFXN3	Sideroflexin-3	3.786551322	7.489516367	3.016900194	2.248646195	5.6380338445	2.6327731945	5.6380338445	2.6327731945	2.14148102703193	0.209060	0	0.466966546692215	0.208505	0	GO:0031305,integral component of mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0016021,integral component of membrane;GO:0031966,mitochondrial membrane	GO:0022889,serine transmembrane transporter activity;GO:0022857,transmembrane transporter activity;GO:0015075,ion transmembrane transporter activity	GO:1990542,mitochondrial transmembrane transport;GO:0006730,one-carbon metabolic process;GO:0140300,serine import into mitochondrion;GO:0006865,amino acid transport	
CLD1_HUMAN	O95832	CLDN1	Claudin-1	0.915650105	0.284947288	0.125179527	2.55E-05	0.6002986965	0.0626025135	0.6002986965	0.0626025135	9.58905102907729	0.019075	1	0.104285606257351	0.018855	-1	GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0005923,bicellular tight junction;GO:0005737,cytoplasm;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0016328,lateral plasma membrane;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0070160,tight junction	GO:0042802,identical protein binding;GO:0005198,structural molecule activity;GO:0001618,virus receptor activity	GO:0007568,aging;GO:0070830,bicellular tight junction assembly;GO:0016338,calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules;GO:0007155,cell adhesion;GO:0034331,cell junction maintenance;GO:0045216,cell-cell junction organization;GO:1903545,cellular response to butyrate;GO:0071346,cellular response to interferon-gamma;GO:0071284,cellular response to lead ion;GO:0071560,cellular response to transforming growth factor beta stimulus;GO:0071356,cellular response to tumor necrosis factor;GO:0008065,establishment of blood-nerve barrier;GO:0090557,establishment of endothelial intestinal barrier;GO:0061436,establishment of skin barrier;GO:0042538,hyperosmotic salinity response;GO:0097421,liver regeneration;GO:0035633,maintenance of blood-brain barrier;GO:1903348,positive regulation of bicellular tight junction assembly;GO:0030335,positive regulation of cell migration;GO:0060054,positive regulation of epithelial cell proliferation involved in wound healing;GO:0090303,positive regulation of wound healing;GO:0051259,protein complex oligomerization;GO:0071548,response to dexamethasone;GO:0045471,response to ethanol;GO:0070673,response to interleukin-18;GO:0032496,response to lipopolysaccharide;GO:0009636,response to toxic substance;GO:0061772,xenobiotic transport across blood-nerve barrier	hsa:9076,path:hsa04514,Cell adhesion molecules (CAMs);hsa:9076,path:hsa04530,Tight junction;hsa:9076,path:hsa04670,Leukocyte transendothelial migration;hsa:9076,path:hsa05130,Pathogenic Escherichia coli infection;hsa:9076,path:hsa05160,Hepatitis C
GILT_HUMAN	P13284	IFI30	Gamma-interferon-inducible lysosomal thiol reductase	0.442124407	0.255640919	0.687694916	2.55E-05	0.348882663	0.343860208	0.348882663	0.343860208	1.01460609539328	0.428549	0	0.985604171451764	0.428341	0	GO:0030054,cell junction;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0043231,intracellular membrane-bounded organelle;GO:0043202,lysosomal lumen;GO:0005764,lysosome	GO:0016491,oxidoreductase activity;GO:0016667,oxidoreductase activity, acting on a sulfur group of donors	GO:0042590,antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0048147,negative regulation of fibroblast proliferation;GO:0050821,protein stabilization	hsa:10437,path:hsa04612,Antigen processing and presentation
HNMT_HUMAN	P50135	HNMT	Histamine N-methyltransferase	0.468434558	1.579402842	0.573454043	0.62143971	1.0239187	0.5974468765	1.0239187	0.5974468765	1.71382383986738	0.266997	0	0.583490541290046	0.266499	0	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0043005,neuron projection;GO:0005654,nucleoplasm	GO:0046539,histamine N-methyltransferase activity	GO:0007420,brain development;GO:0001695,histamine catabolic process;GO:0001692,histamine metabolic process;GO:0006548,histidine catabolic process;GO:0006972,hyperosmotic response;GO:0032259,methylation;GO:0007585,respiratory gaseous exchange by respiratory system;GO:0014075,response to amine;GO:0042220,response to cocaine;GO:0051384,response to glucocorticoid;GO:0035902,response to immobilization stress;GO:0070555,response to interleukin-1;GO:0002347,response to tumor cell	hsa:3176,path:hsa00340,Histidine metabolism
PGRC2_HUMAN	O15173	PGRMC2	Membrane-associated progesterone receptor component 2	1.494649866	2.448221854	1.23826549	1.335684478	1.97143586	1.286974984	1.97143586	1.286974984	1.53183697003391	0.298992	0	0.652810984172724	0.298540	0	GO:0012505,endomembrane system;GO:0005783,endoplasmic reticulum;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005635,nuclear envelope	GO:0020037,heme binding;GO:0015232,heme transmembrane transporter activity;GO:0005496,steroid binding;GO:0003707,steroid hormone receptor activity	GO:0060612,adipose tissue development	
APOH_HUMAN	P02749	APOH	Beta-2-glycoprotein 1	2.440852142	0.889973735	1.632464626	24.85567777	1.6654129385	13.244071198	1.6654129385	13.244071198	0.125747809234935	0.002089	-1	7.95242482619874	0.002112	1	GO:0009986,cell surface;GO:0042627,chylomicron;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0034364,high-density lipoprotein particle;GO:0031089,platelet dense granule lumen;GO:0034361,very-low-density lipoprotein particle	GO:0008201,heparin binding;GO:0042802,identical protein binding;GO:0008289,lipid binding;GO:0060230,lipoprotein lipase activator activity;GO:0005543,phospholipid binding	GO:0007597,blood coagulation, intrinsic pathway;GO:0016525,negative regulation of angiogenesis;GO:0030195,negative regulation of blood coagulation;GO:0010596,negative regulation of endothelial cell migration;GO:0001937,negative regulation of endothelial cell proliferation;GO:0051918,negative regulation of fibrinolysis;GO:0033033,negative regulation of myeloid cell apoptotic process;GO:0034392,negative regulation of smooth muscle cell apoptotic process;GO:0031639,plasminogen activation;GO:0002576,platelet degranulation;GO:0030194,positive regulation of blood coagulation;GO:0051006,positive regulation of lipoprotein lipase activity;GO:0051917,regulation of fibrinolysis;GO:0006641,triglyceride metabolic process;GO:0034197,triglyceride transport	hsa:350,path:hsa04979,Cholesterol metabolism
NAGAB_HUMAN	P17050	NAGA	Alpha-N-acetylgalactosaminidase	0.311202633	0.34171813	0.517409413	0.603656084	0.3264603815	0.5605327485	0.3264603815	0.5605327485	0.582410898156471	0.300908	0	1.7170008376652	0.301196	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005764,lysosome	GO:0004557,alpha-galactosidase activity;GO:0008456,alpha-N-acetylgalactosaminidase activity;GO:0042803,protein homodimerization activity	GO:0016052,carbohydrate catabolic process;GO:0019377,glycolipid catabolic process;GO:0016139,glycoside catabolic process;GO:0046477,glycosylceramide catabolic process;GO:0009311,oligosaccharide metabolic process	hsa:4668,path:hsa00603,Glycosphingolipid biosynthesis - globo and isoglobo series;hsa:4668,path:hsa04142,Lysosome
STX7_HUMAN	O15400	STX7	Syntaxin-7	0.734786334	1.15530385	1.241032501	1.937091234	0.945045092	1.5890618675	0.945045092	1.5890618675	0.594718878684565	0.312126	0	1.68146671619347	0.312406	0	GO:0042582,azurophil granule;GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0030139,endocytic vesicle;GO:0012505,endomembrane system;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0001772,immunological synapse;GO:0016021,integral component of membrane;GO:0005770,late endosome;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0055037,recycling endosome;GO:0031201,SNARE complex;GO:0008021,synaptic vesicle;GO:0070820,tertiary granule;GO:0031982,vesicle	GO:0019869,chloride channel inhibitor activity;GO:0005484,SNAP receptor activity;GO:0000149,SNARE binding;GO:0019905,syntaxin binding	GO:0006886,intracellular protein transport;GO:0070925,organelle assembly;GO:0051640,organelle localization;GO:1902685,positive regulation of receptor localization to synapse;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:1903076,regulation of protein localization to plasma membrane;GO:0048278,vesicle docking;GO:0006906,vesicle fusion	hsa:8417,path:hsa04130,SNARE interactions in vesicular transport;hsa:8417,path:hsa04145,Phagosome
COPA_HUMAN	P53621	COPA	Coatomer subunit alpha	19.80326243	18.89412612	25.25996148	16.57973508	19.348694275	20.91984828	19.348694275	20.91984828	0.924896491409927	0.459361	0	1.08120206886674	0.459221	0	GO:0030126,COPI vesicle coat;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0000139,Golgi membrane;GO:0030426,growth cone;GO:0016020,membrane;GO:0030133,transport vesicle;GO:0030117,membrane coat;GO:0030663,COPI-coated vesicle membrane	GO:0005179,hormone activity;GO:0005198,structural molecule activity	GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006891,intra-Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0030157,pancreatic juice secretion;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0016192,vesicle-mediated transport	
ITA1_HUMAN	P56199	ITGA1	Integrin alpha-1	1.595629487	2.083672769	1.950509085	9.85304584	1.839651128	5.9017774625	1.839651128	5.9017774625	0.311711368259677	0.069828	0	3.20809602031239	0.070086	0	GO:0001669,acrosomal vesicle;GO:0045178,basal part of cell;GO:0009986,cell surface;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0034665,integrin alpha1-beta1 complex;GO:0008305,integrin complex;GO:0016020,membrane;GO:0045121,membrane raft;GO:0043005,neuron projection;GO:0043204,perikaryon;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0005518,collagen binding;GO:0098639,collagen binding involved in cell-matrix adhesion;GO:0046872,metal ion binding;GO:0019903,protein phosphatase binding;GO:0005102,signaling receptor binding	GO:0000187,activation of MAPK activity;GO:0007160,cell-matrix adhesion;GO:0045123,cellular extravasation;GO:0030198,extracellular matrix organization;GO:0007229,integrin-mediated signaling pathway;GO:0006936,muscle contraction;GO:0008285,negative regulation of cell population proliferation;GO:0042059,negative regulation of epidermal growth factor receptor signaling pathway;GO:0048812,neuron projection morphogenesis;GO:0030593,neutrophil chemotaxis;GO:0043525,positive regulation of neuron apoptotic process;GO:0032516,positive regulation of phosphoprotein phosphatase activity;GO:0042311,vasodilation;GO:0007155,cell adhesion	hsa:3672,path:hsa04151,PI3K-Akt signaling pathway;hsa:3672,path:hsa04512,ECM-receptor interaction;hsa:3672,path:hsa04510,Focal adhesion;hsa:3672,path:hsa04810,Regulation of actin cytoskeleton;hsa:3672,path:hsa04640,Hematopoietic cell lineage;hsa:3672,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:3672,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:3672,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:3672,path:hsa05165,Human papillomavirus infection
MYL1_HUMAN	P05976	MYL1	Myosin light chain 1/3, skeletal muscle isoform	0.014201585	0.119147999	0.115437436	0.009056634	0.066674792	0.062247035	0.066674792	0.062247035	1.07113201456101	0.410691	0	0.93359173883887	0.410446	0	GO:0005829,cytosol;GO:0005859,muscle myosin complex;GO:0030016,myofibril;GO:0030017,sarcomere	GO:0005509,calcium ion binding;GO:0008307,structural constituent of muscle	GO:0060048,cardiac muscle contraction;GO:0006936,muscle contraction;GO:0030049,muscle filament sliding	
IF5_HUMAN	P55010	EIF5	Eukaryotic translation initiation factor 5	0.83149622	0.651357438	1.44625232	0.914749462	0.741426829	1.180500891	0.741426829	1.180500891	0.628061219311693	0.342199	0	1.59220147535287	0.342454	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005886,plasma membrane	GO:0045296,cadherin binding;GO:0071074,eukaryotic initiation factor eIF2 binding;GO:0005092,GDP-dissociation inhibitor activity;GO:0005525,GTP binding;GO:0003723,RNA binding;GO:0003743,translation initiation factor activity	GO:0090630,activation of GTPase activity;GO:0001732,formation of cytoplasmic translation initiation complex;GO:0001731,formation of translation preinitiation complex;GO:0006446,regulation of translational initiation	hsa:1983,path:hsa03013,RNA transport
TBA1C_HUMAN	Q9BQE3	TUBA1C	Tubulin alpha-1C chain	0.812422665	2.694809767	6.716805528	1.285416375	1.753616216	4.0011109515	1.753616216	4.0011109515	0.438282326398016	0.169465	0	2.28163432511279	0.169800	0	GO:0005737,cytoplasm;GO:0005874,microtubule;GO:0015630,microtubule cytoskeleton;GO:0005634,nucleus;GO:0031982,vesicle	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0005200,structural constituent of cytoskeleton;GO:0005198,structural molecule activity	GO:0051301,cell division;GO:0030705,cytoskeleton-dependent intracellular transport;GO:0000226,microtubule cytoskeleton organization;GO:0007017,microtubule-based process;GO:0000278,mitotic cell cycle	hsa:84790,path:hsa04145,Phagosome;hsa:84790,path:hsa04210,Apoptosis;hsa:84790,path:hsa04530,Tight junction;hsa:84790,path:hsa04540,Gap junction;hsa:84790,path:hsa05130,Pathogenic Escherichia coli infection
CIA2A_HUMAN	Q9H5X1	CIAO2A	Cytosolic iron-sulfur assembly component 2A	0.42910229	1.030987373	0.041977216	0.003371818	0.7300448315	0.022674517	0.7300448315	0.022674517	32.1967092617673	0.000987	1	0.0310590747603971	0.000964	-1	GO:0097361,CIA complex;GO:0005829,cytosol;GO:0005654,nucleoplasm	GO:0046872,metal ion binding	GO:0007059,chromosome segregation;GO:0016226,iron-sulfur cluster assembly;GO:0106035,protein maturation by [4Fe-4S] cluster transfer;GO:0097428,protein maturation by iron-sulfur cluster transfer	
LEMD2_HUMAN	Q8NC56	LEMD2	LEM domain-containing protein 2	0.49414132	0.457274053	0.41383977	0.984124071	0.4757076865	0.6989819205	0.4757076865	0.6989819205	0.680572233055347	0.388297	0	1.46935174758838	0.388509	0	GO:0016021,integral component of membrane;GO:0005639,integral component of nuclear inner membrane;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0005637,nuclear inner membrane;GO:0031965,nuclear membrane	GO:0031490,chromatin DNA binding	GO:0060914,heart formation;GO:0007084,mitotic nuclear envelope reassembly;GO:0030514,negative regulation of BMP signaling pathway;GO:0043409,negative regulation of MAPK cascade;GO:0051898,negative regulation of protein kinase B signaling;GO:0022008,neurogenesis;GO:0006998,nuclear envelope organization;GO:0071168,protein localization to chromatin;GO:0035914,skeletal muscle cell differentiation;GO:1902531,regulation of intracellular signal transduction	
DDI2_HUMAN	Q5TDH0	DDI2	Protein DDI1 homolog 2	1.711847115	0.621399039	1.555748713	5.450755598	1.166623077	3.5032521555	1.166623077	3.5032521555	0.333011449138321	0.084401	0	3.00289975791384	0.084681	0	GO:0005694,chromosome;GO:0005829,cytosol;GO:0005654,nucleoplasm	GO:0004190,aspartic-type endopeptidase activity;GO:0042802,identical protein binding;GO:0043130,ubiquitin binding	GO:0072711,cellular response to hydroxyurea;GO:0010498,proteasomal protein catabolic process;GO:0016485,protein processing;GO:0097752,regulation of DNA stability;GO:0031647,regulation of protein stability	
ARF5_HUMAN	P84085	ARF5	ADP-ribosylation factor 5	4.318750204	2.127645366	0.32219351	0.222059417	3.223197785	0.2721264635	3.223197785	0.2721264635	11.8444848896513	0.012184	1	0.0844274790602092	0.012021	-1	GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane	GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0006886,intracellular protein transport;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0016192,vesicle-mediated transport	hsa:381,path:hsa04144,Endocytosis
RNPS1_HUMAN	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.044693482	0.031626739	0.28293263	0.160265116	0.0381601105	0.221598873	0.0381601105	0.221598873	0.172203540493638	0.008565	-1	5.80708153347722	0.008634	1	GO:0061574,ASAP complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003730,mRNA 3'-UTR binding;GO:0003723,RNA binding	GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0048025,negative regulation of mRNA splicing, via spliceosome;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0043065,positive regulation of apoptotic process;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0006405,RNA export from nucleus;GO:0008380,RNA splicing;GO:0006351,transcription, DNA-templated	hsa:10921,path:hsa03013,RNA transport;hsa:10921,path:hsa03015,mRNA surveillance pathway
TNPO2_HUMAN	O14787	TNPO2	Transportin-2	0.021178866	2.55E-05	0.022044707	2.55E-05	0.010602183	0.0110351035	0.010602183	0.0110351035	0.960768786627148	0.446655	0	1.04083314728674	0.446487	0	GO:0005737,cytoplasm;GO:0005634,nucleus	GO:0061608,nuclear import signal receptor activity;GO:0008139,nuclear localization sequence binding;GO:0031267,small GTPase binding	GO:0006606,protein import into nucleus	
CHD4_HUMAN	Q14839	CHD4	Chromodomain-helicase-DNA-binding protein 4	1.300206084	0.739991179	1.456591888	1.114162293	1.0200986315	1.2853770905	1.0200986315	1.2853770905	0.793618183363756	0.480491	0	1.26005177421905	0.480604	0	GO:0005813,centrosome;GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0016581,NuRD complex;GO:0032991,protein-containing complex;GO:0090575,RNA polymerase II transcription regulator complex	GO:0005524,ATP binding;GO:0003677,DNA binding;GO:0003678,DNA helicase activity;GO:0042826,histone deacetylase binding;GO:0070615,nucleosome-dependent ATPase activity;GO:0001103,RNA polymerase II repressing transcription factor binding;GO:0008134,transcription factor binding;GO:0008270,zinc ion binding;GO:0016787,hydrolase activity;GO:0046872,metal ion binding;GO:0004386,helicase activity	GO:0043044,ATP-dependent chromatin remodeling;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0006357,regulation of transcription by RNA polymerase II;GO:0006325,chromatin organization	hsa:1108,path:hsa05203,Viral carcinogenesis;hsa:1108,path:hsa05165,Human papillomavirus infection
CISD2_HUMAN	Q8N5K1	CISD2	CDGSH iron-sulfur domain-containing protein 2	2.150365342	4.837536411	0.240722284	0.080009331	3.4939508765	0.1603658075	3.4939508765	0.1603658075	21.7873805580407	0.002846	1	0.0458981288427969	0.002792	-1	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0097038,perinuclear endoplasmic reticulum;GO:0032991,protein-containing complex;GO:0043231,intracellular membrane-bounded organelle	GO:0051537,2 iron, 2 sulfur cluster binding;GO:0046872,metal ion binding;GO:0042803,protein homodimerization activity;GO:0003723,RNA binding	GO:0000422,autophagy of mitochondrion;GO:0010259,multicellular organism aging;GO:0010506,regulation of autophagy	
DEK_HUMAN	P35659	DEK	Protein DEK	1.413180029	4.213608789	0.631369171	0.964073928	2.813394409	0.7977215495	2.813394409	0.7977215495	3.52678752474895	0.109314	0	0.283544158241057	0.108778	0	GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0043292,contractile fiber	GO:0003677,DNA binding;GO:0042393,histone binding;GO:0003723,RNA binding	GO:0006325,chromatin organization;GO:0030851,granulocyte differentiation;GO:0045815,positive regulation of gene expression, epigenetic;GO:2000779,regulation of double-strand break repair;GO:0006357,regulation of transcription by RNA polymerase II;GO:0007165,signal transduction;GO:0006366,transcription by RNA polymerase II;GO:0019079,viral genome replication;GO:2001032,regulation of double-strand break repair via nonhomologous end joining	
RAN_HUMAN	P62826	RAN	GTP-binding nuclear protein Ran	35.54827768	46.157046	12.64781739	7.514906629	40.85266184	10.0813620095	40.85266184	10.0813620095	4.05229589032744	0.088949	0	0.246773687574724	0.088446	0	GO:0005814,centriole;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0043657,host cell;GO:0042470,melanosome;GO:0016020,membrane;GO:0030496,midbody;GO:0005635,nuclear envelope;GO:0005643,nuclear pore;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0055037,recycling endosome;GO:0042565,RNA nuclear export complex	GO:0045296,cadherin binding;GO:0003682,chromatin binding;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0000287,magnesium ion binding;GO:0046982,protein heterodimerization activity;GO:0003723,RNA binding	GO:0051301,cell division;GO:0006259,DNA metabolic process;GO:0046039,GTP metabolic process;GO:0075733,intracellular transport of virus;GO:0010586,miRNA metabolic process;GO:0000278,mitotic cell cycle;GO:0007084,mitotic nuclear envelope reassembly;GO:0000070,mitotic sister chromatid segregation;GO:0007052,mitotic spindle organization;GO:0032092,positive regulation of protein binding;GO:0042307,positive regulation of protein import into nucleus;GO:0035281,pre-miRNA export from nucleus;GO:0006611,protein export from nucleus;GO:0006606,protein import into nucleus;GO:1902570,protein localization to nucleolus;GO:0045540,regulation of cholesterol biosynthetic process;GO:0000055,ribosomal large subunit export from nucleus;GO:0000056,ribosomal small subunit export from nucleus;GO:0000054,ribosomal subunit export from nucleus;GO:0061015,snRNA import into nucleus;GO:0006409,tRNA export from nucleus;GO:0016032,viral process;GO:0006913,nucleocytoplasmic transport;GO:0015031,protein transport	hsa:5901,path:hsa03013,RNA transport;hsa:5901,path:hsa03008,Ribosome biogenesis in eukaryotes;hsa:5901,path:hsa05166,Human T-cell leukemia virus 1 infection
NPL_HUMAN	Q9BXD5	NPL	N-acetylneuraminate lyase	0.184187735	0.335679169	1.111209387	0.229944835	0.259933452	0.670577111	0.259933452	0.670577111	0.387626490281444	0.126316	0	2.5798030451271	0.126636	0	GO:0005829,cytosol	GO:0042802,identical protein binding;GO:0008747,N-acetylneuraminate lyase activity;GO:0016829,lyase activity	GO:0005975,carbohydrate metabolic process;GO:0019262,N-acetylneuraminate catabolic process	hsa:80896,path:hsa00520,Amino sugar and nucleotide sugar metabolism
S100B_HUMAN	P04271	S100B	Protein S100-B	0.049084676	0.383700958	0.046381069	2.55E-05	0.216392817	0.0232032845	0.216392817	0.0232032845	9.32595628864525	0.020192	1	0.107227609592975	0.019964	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043231,intracellular membrane-bounded organelle;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0001726,ruffle	GO:0005509,calcium ion binding;GO:0048306,calcium-dependent protein binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:0050786,RAGE receptor binding;GO:0044548,S100 protein binding;GO:0048156,tau protein binding;GO:0008270,zinc ion binding	GO:0007409,axonogenesis;GO:0007417,central nervous system development;GO:0045087,innate immune response;GO:0007611,learning or memory;GO:0008284,positive regulation of cell population proliferation;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling	
UBP2L_HUMAN	Q14157	UBAP2L	Ubiquitin-associated protein 2-like	0.124926053	0.015264374	0.132978185	0.029087174	0.0700952135	0.0810326795	0.0700952135	0.0810326795	0.865024011701353	0.481801	0	1.15603727350085	0.481710	0	GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005634,nucleus;GO:0031519,PcG protein complex	GO:0003723,RNA binding	GO:0007339,binding of sperm to zona pellucida;GO:0061484,hematopoietic stem cell homeostasis;GO:0034063,stress granule assembly	
IGHG3_HUMAN	P01860	IGHG3	Immunoglobulin heavy constant gamma 3	275.7608936	222.325012	240.2025557	626.3308721	249.0429528	433.2667139	249.0429528	433.2667139	0.574802875019567	0.293949	0	1.73972685847467	0.294241	0	GO:0072562,blood microparticle;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0042571,immunoglobulin complex, circulating;GO:0016021,integral component of membrane	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0045087,innate immune response;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0030449,regulation of complement activation;GO:0001895,retina homeostasis	
DMB_HUMAN	P28068	HLA-DMB	HLA class II histocompatibility antigen, DM beta chain	0.136079543	0.1057891	0.217831904	2.55E-05	0.1209343215	0.108928702	0.1209343215	0.108928702	1.11021539116476	0.398986	0	0.900726118515495	0.398717	0	GO:0009986,cell surface;GO:0031901,early endosome membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0000139,Golgi membrane;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0042612,MHC class I protein complex;GO:0032398,MHC class Ib protein complex;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0030667,secretory granule membrane;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0030666,endocytic vesicle membrane;GO:0001772,immunological synapse;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0042613,MHC class II protein complex;GO:0032588,trans-Golgi network membrane;GO:0030658,transport vesicle membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0010008,endosome membrane;GO:0005882,intermediate filament;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0005797,Golgi medial cisterna;GO:0042824,MHC class I peptide loading complex;GO:0035577,azurophil granule membrane;GO:0033106,cis-Golgi network membrane;GO:0005769,early endosome;GO:0031527,filopodium membrane;GO:0005771,multivesicular body	GO:0030881,beta-2-microglobulin binding;GO:0042288,MHC class I protein binding;GO:0046703,natural killer cell lectin-like receptor binding;GO:0042605,peptide antigen binding;GO:0005102,signaling receptor binding;GO:0042608,T cell receptor binding;GO:0051087,chaperone binding;GO:0046977,TAP binding;GO:0023026,MHC class II protein complex binding;GO:0032395,MHC class II receptor activity;GO:0030247,polysaccharide binding;GO:0042609,CD4 receptor binding;GO:0005200,structural constituent of cytoskeleton;GO:0042610,CD8 receptor binding;GO:0003723,RNA binding;GO:0062061,TAP complex binding;GO:0071889,14-3-3 protein binding;GO:0046978,TAP1 binding;GO:0046979,TAP2 binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:1990405,protein antigen binding;GO:0015643,toxic substance binding;GO:0008134,transcription factor binding;GO:0031625,ubiquitin protein ligase binding;GO:0046872,metal ion binding	GO:0002250,adaptive immune response;GO:0019731,antibacterial humoral response;GO:0002476,antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0002477,antigen processing and presentation of exogenous peptide antigen via MHC class Ib;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0036037,CD8-positive, alpha-beta T cell activation;GO:0050830,defense response to Gram-positive bacterium;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0002519,natural killer cell tolerance induction;GO:0045953,negative regulation of natural killer cell mediated cytotoxicity;GO:0001815,positive regulation of antibody-dependent cellular cytotoxicity;GO:2001187,positive regulation of CD8-positive, alpha-beta T cell activation;GO:2000566,positive regulation of CD8-positive, alpha-beta T cell proliferation;GO:0002639,positive regulation of immunoglobulin production;GO:0032736,positive regulation of interleukin-13 production;GO:0032753,positive regulation of interleukin-4 production;GO:0002729,positive regulation of natural killer cell cytokine production;GO:0045954,positive regulation of natural killer cell mediated cytotoxicity;GO:0002717,positive regulation of natural killer cell mediated immunity;GO:0032819,positive regulation of natural killer cell proliferation;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:0032759,positive regulation of TRAIL production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0042270,protection from natural killer cell mediated cytotoxicity;GO:0050776,regulation of immune response;GO:0002715,regulation of natural killer cell mediated immunity;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process;GO:0002486,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006952,defense response;GO:0016045,detection of bacterium;GO:0006955,immune response;GO:0043312,neutrophil degranulation;GO:2001198,regulation of dendritic cell differentiation;GO:0032655,regulation of interleukin-12 production;GO:0032675,regulation of interleukin-6 production;GO:0002667,regulation of T cell anergy;GO:0002491,antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002504,antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0050890,cognition;GO:0002469,myeloid dendritic cell antigen processing and presentation;GO:0002503,peptide antigen assembly with MHC class II protein complex;GO:2000516,positive regulation of CD4-positive, alpha-beta T cell activation;GO:0032831,positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0043382,positive regulation of memory T cell differentiation;GO:0045622,regulation of T-helper cell differentiation;GO:0050852,T cell receptor signaling pathway;GO:0002399,MHC class II protein complex assembly;GO:2001190,positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0042102,positive regulation of T cell proliferation;GO:0032729,positive regulation of interferon-gamma production;GO:0050870,positive regulation of T cell activation;GO:0008544,epidermis development;GO:0006959,humoral immune response;GO:0002437,inflammatory response to antigenic stimulus;GO:0030225,macrophage differentiation;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0032689,negative regulation of interferon-gamma production;GO:0042130,negative regulation of T cell proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0033674,positive regulation of kinase activity;GO:0043410,positive regulation of MAPK cascade;GO:0045657,positive regulation of monocyte differentiation;GO:0001934,positive regulation of protein phosphorylation;GO:0002842,positive regulation of T cell mediated immune response to tumor cell;GO:0045893,positive regulation of transcription, DNA-templated;GO:0046598,positive regulation of viral entry into host cell;GO:0051262,protein tetramerization;GO:0032653,regulation of interleukin-10 production;GO:0032673,regulation of interleukin-4 production;GO:0007165,signal transduction;GO:0042088,T-helper 1 type immune response;GO:0002587,negative regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0045580,regulation of T cell differentiation;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002485,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent;GO:0042590,antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:2000568,positive regulation of memory T cell activation;GO:0002726,positive regulation of T cell cytokine production;GO:0016567,protein ubiquitination;GO:0001913,T cell mediated cytotoxicity;GO:0002419,T cell mediated cytotoxicity directed against tumor cell target;GO:0002728,negative regulation of natural killer cell cytokine production;GO:0043322,negative regulation of natural killer cell degranulation;GO:1901215,negative regulation of neuron death;GO:0002725,negative regulation of T cell cytokine production;GO:0043323,positive regulation of natural killer cell degranulation;GO:0071346,cellular response to interferon-gamma;GO:0006968,cellular defense response;GO:0002767,immune response-inhibiting cell surface receptor signaling pathway;GO:0016525,negative regulation of angiogenesis;GO:2001199,negative regulation of dendritic cell differentiation;GO:0070317,negative regulation of G0 to G1 transition;GO:0050777,negative regulation of immune response;GO:0051898,negative regulation of protein kinase B signaling;GO:0001915,negative regulation of T cell mediated cytotoxicity;GO:0002451,peripheral B cell tolerance induction;GO:2000774,positive regulation of cellular senescence;GO:2000353,positive regulation of endothelial cell apoptotic process;GO:0032735,positive regulation of interleukin-12 production;GO:0060907,positive regulation of macrophage cytokine production;GO:0045591,positive regulation of regulatory T cell differentiation;GO:0002666,positive regulation of T cell tolerance induction;GO:0002645,positive regulation of tolerance induction;GO:0070207,protein homotrimerization;GO:0019882,antigen processing and presentation;GO:0002344,B cell affinity maturation;GO:0046635,positive regulation of alpha-beta T cell activation;GO:0002579,positive regulation of antigen processing and presentation;GO:0002827,positive regulation of T-helper 1 type immune response	hsa:3133,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3133,path:hsa04144,Endocytosis;hsa:3133,path:hsa04145,Phagosome;hsa:3133,path:hsa04218,Cellular senescence;hsa:3133,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3133,path:hsa04612,Antigen processing and presentation;hsa:3133,path:hsa05203,Viral carcinogenesis;hsa:3133,path:hsa05320,Autoimmune thyroid disease;hsa:3133,path:hsa05330,Allograft rejection;hsa:3133,path:hsa05332,Graft-versus-host disease;hsa:3133,path:hsa05416,Viral myocarditis;hsa:3133,path:hsa04940,Type I diabetes mellitus;hsa:3133,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3133,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3133,path:hsa05168,Herpes simplex virus 1 infection;hsa:3133,path:hsa05163,Human cytomegalovirus infection;hsa:3133,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3133,path:hsa05169,Epstein-Barr virus infection;hsa:3133,path:hsa05165,Human papillomavirus infection;hsa:3106,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3106,path:hsa04144,Endocytosis;hsa:3106,path:hsa04145,Phagosome;hsa:3106,path:hsa04218,Cellular senescence;hsa:3106,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3106,path:hsa04612,Antigen processing and presentation;hsa:3106,path:hsa05203,Viral carcinogenesis;hsa:3106,path:hsa05320,Autoimmune thyroid disease;hsa:3106,path:hsa05330,Allograft rejection;hsa:3106,path:hsa05332,Graft-versus-host disease;hsa:3106,path:hsa05416,Viral myocarditis;hsa:3106,path:hsa04940,Type I diabetes mellitus;hsa:3106,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3106,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3106,path:hsa05168,Herpes simplex virus 1 infection;hsa:3106,path:hsa05163,Human cytomegalovirus infection;hsa:3106,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3106,path:hsa05169,Epstein-Barr virus infection;hsa:3106,path:hsa05165,Human papillomavirus infection;hsa:3122,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3122,path:hsa04145,Phagosome;hsa:3122,path:hsa04640,Hematopoietic cell lineage;hsa:3122,path:hsa04612,Antigen processing and presentation;hsa:3122,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3122,path:hsa04659,Th17 cell differentiation;hsa:3122,path:hsa04672,Intestinal immune network for IgA production;hsa:3122,path:hsa05310,Asthma;hsa:3122,path:hsa05322,Systemic lupus erythematosus;hsa:3122,path:hsa05323,Rheumatoid arthritis;hsa:3122,path:hsa05320,Autoimmune thyroid disease;hsa:3122,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3122,path:hsa05330,Allograft rejection;hsa:3122,path:hsa05332,Graft-versus-host disease;hsa:3122,path:hsa05416,Viral myocarditis;hsa:3122,path:hsa04940,Type I diabetes mellitus;hsa:3122,path:hsa05150,Staphylococcus aureus infection;hsa:3122,path:hsa05152,Tuberculosis;hsa:3122,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3122,path:hsa05164,Influenza A;hsa:3122,path:hsa05168,Herpes simplex virus 1 infection;hsa:3122,path:hsa05169,Epstein-Barr virus infection;hsa:3122,path:hsa05145,Toxoplasmosis;hsa:3122,path:hsa05140,Leishmaniasis;hsa:3109,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3109,path:hsa04145,Phagosome;hsa:3109,path:hsa04640,Hematopoietic cell lineage;hsa:3109,path:hsa04612,Antigen processing and presentation;hsa:3109,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3109,path:hsa04659,Th17 cell differentiation;hsa:3109,path:hsa04672,Intestinal immune network for IgA production;hsa:3109,path:hsa05310,Asthma;hsa:3109,path:hsa05322,Systemic lupus erythematosus;hsa:3109,path:hsa05323,Rheumatoid arthritis;hsa:3109,path:hsa05320,Autoimmune thyroid disease;hsa:3109,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3109,path:hsa05330,Allograft rejection;hsa:3109,path:hsa05332,Graft-versus-host disease;hsa:3109,path:hsa05416,Viral myocarditis;hsa:3109,path:hsa04940,Type I diabetes mellitus;hsa:3109,path:hsa05150,Staphylococcus aureus infection;hsa:3109,path:hsa05152,Tuberculosis;hsa:3109,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3109,path:hsa05164,Influenza A;hsa:3109,path:hsa05168,Herpes simplex virus 1 infection;hsa:3109,path:hsa05169,Epstein-Barr virus infection;hsa:3109,path:hsa05145,Toxoplasmosis;hsa:3109,path:hsa05140,Leishmaniasis;hsa:3115,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3115,path:hsa04145,Phagosome;hsa:3115,path:hsa04640,Hematopoietic cell lineage;hsa:3115,path:hsa04612,Antigen processing and presentation;hsa:3115,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3115,path:hsa04659,Th17 cell differentiation;hsa:3115,path:hsa04672,Intestinal immune network for IgA production;hsa:3115,path:hsa05310,Asthma;hsa:3115,path:hsa05322,Systemic lupus erythematosus;hsa:3115,path:hsa05323,Rheumatoid arthritis;hsa:3115,path:hsa05320,Autoimmune thyroid disease;hsa:3115,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3115,path:hsa05330,Allograft rejection;hsa:3115,path:hsa05332,Graft-versus-host disease;hsa:3115,path:hsa05416,Viral myocarditis;hsa:3115,path:hsa04940,Type I diabetes mellitus;hsa:3115,path:hsa05150,Staphylococcus aureus infection;hsa:3115,path:hsa05152,Tuberculosis;hsa:3115,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3115,path:hsa05164,Influenza A;hsa:3115,path:hsa05168,Herpes simplex virus 1 infection;hsa:3115,path:hsa05169,Epstein-Barr virus infection;hsa:3115,path:hsa05145,Toxoplasmosis;hsa:3115,path:hsa05140,Leishmaniasis;hsa:3123,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3123,path:hsa04145,Phagosome;hsa:3123,path:hsa04640,Hematopoietic cell lineage;hsa:3123,path:hsa04612,Antigen processing and presentation;hsa:3123,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3123,path:hsa04659,Th17 cell differentiation;hsa:3123,path:hsa04672,Intestinal immune network for IgA production;hsa:3123,path:hsa05310,Asthma;hsa:3123,path:hsa05322,Systemic lupus erythematosus;hsa:3123,path:hsa05323,Rheumatoid arthritis;hsa:3123,path:hsa05320,Autoimmune thyroid disease;hsa:3123,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3123,path:hsa05330,Allograft rejection;hsa:3123,path:hsa05332,Graft-versus-host disease;hsa:3123,path:hsa05416,Viral myocarditis;hsa:3123,path:hsa04940,Type I diabetes mellitus;hsa:3123,path:hsa05150,Staphylococcus aureus infection;hsa:3123,path:hsa05152,Tuberculosis;hsa:3123,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3123,path:hsa05164,Influenza A;hsa:3123,path:hsa05168,Herpes simplex virus 1 infection;hsa:3123,path:hsa05169,Epstein-Barr virus infection;hsa:3123,path:hsa05145,Toxoplasmosis;hsa:3123,path:hsa05140,Leishmaniasis;hsa:3111,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3111,path:hsa04145,Phagosome;hsa:3111,path:hsa04640,Hematopoietic cell lineage;hsa:3111,path:hsa04612,Antigen processing and presentation;hsa:3111,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3111,path:hsa04659,Th17 cell differentiation;hsa:3111,path:hsa04672,Intestinal immune network for IgA production;hsa:3111,path:hsa05310,Asthma;hsa:3111,path:hsa05322,Systemic lupus erythematosus;hsa:3111,path:hsa05323,Rheumatoid arthritis;hsa:3111,path:hsa05320,Autoimmune thyroid disease;hsa:3111,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3111,path:hsa05330,Allograft rejection;hsa:3111,path:hsa05332,Graft-versus-host disease;hsa:3111,path:hsa05416,Viral myocarditis;hsa:3111,path:hsa04940,Type I diabetes mellitus;hsa:3111,path:hsa05150,Staphylococcus aureus infection;hsa:3111,path:hsa05152,Tuberculosis;hsa:3111,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3111,path:hsa05164,Influenza A;hsa:3111,path:hsa05168,Herpes simplex virus 1 infection;hsa:3111,path:hsa05169,Epstein-Barr virus infection;hsa:3111,path:hsa05145,Toxoplasmosis;hsa:3111,path:hsa05140,Leishmaniasis;hsa:3112,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3112,path:hsa04145,Phagosome;hsa:3112,path:hsa04640,Hematopoietic cell lineage;hsa:3112,path:hsa04612,Antigen processing and presentation;hsa:3112,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3112,path:hsa04659,Th17 cell differentiation;hsa:3112,path:hsa04672,Intestinal immune network for IgA production;hsa:3112,path:hsa05310,Asthma;hsa:3112,path:hsa05322,Systemic lupus erythematosus;hsa:3112,path:hsa05323,Rheumatoid arthritis;hsa:3112,path:hsa05320,Autoimmune thyroid disease;hsa:3112,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3112,path:hsa05330,Allograft rejection;hsa:3112,path:hsa05332,Graft-versus-host disease;hsa:3112,path:hsa05416,Viral myocarditis;hsa:3112,path:hsa04940,Type I diabetes mellitus;hsa:3112,path:hsa05150,Staphylococcus aureus infection;hsa:3112,path:hsa05152,Tuberculosis;hsa:3112,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3112,path:hsa05164,Influenza A;hsa:3112,path:hsa05168,Herpes simplex virus 1 infection;hsa:3112,path:hsa05169,Epstein-Barr virus infection;hsa:3112,path:hsa05145,Toxoplasmosis;hsa:3112,path:hsa05140,Leishmaniasis;hsa:3105,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3105,path:hsa04144,Endocytosis;hsa:3105,path:hsa04145,Phagosome;hsa:3105,path:hsa04218,Cellular senescence;hsa:3105,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3105,path:hsa04612,Antigen processing and presentation;hsa:3105,path:hsa05203,Viral carcinogenesis;hsa:3105,path:hsa05320,Autoimmune thyroid disease;hsa:3105,path:hsa05330,Allograft rejection;hsa:3105,path:hsa05332,Graft-versus-host disease;hsa:3105,path:hsa05416,Viral myocarditis;hsa:3105,path:hsa04940,Type I diabetes mellitus;hsa:3105,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3105,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3105,path:hsa05168,Herpes simplex virus 1 infection;hsa:3105,path:hsa05163,Human cytomegalovirus infection;hsa:3105,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3105,path:hsa05169,Epstein-Barr virus infection;hsa:3105,path:hsa05165,Human papillomavirus infection;hsa:3134,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3134,path:hsa04144,Endocytosis;hsa:3134,path:hsa04145,Phagosome;hsa:3134,path:hsa04218,Cellular senescence;hsa:3134,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3134,path:hsa04612,Antigen processing and presentation;hsa:3134,path:hsa05203,Viral carcinogenesis;hsa:3134,path:hsa05320,Autoimmune thyroid disease;hsa:3134,path:hsa05330,Allograft rejection;hsa:3134,path:hsa05332,Graft-versus-host disease;hsa:3134,path:hsa05416,Viral myocarditis;hsa:3134,path:hsa04940,Type I diabetes mellitus;hsa:3134,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3134,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3134,path:hsa05168,Herpes simplex virus 1 infection;hsa:3134,path:hsa05163,Human cytomegalovirus infection;hsa:3134,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3134,path:hsa05169,Epstein-Barr virus infection;hsa:3134,path:hsa05165,Human papillomavirus infection;hsa:3119,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3119,path:hsa04145,Phagosome;hsa:3119,path:hsa04640,Hematopoietic cell lineage;hsa:3119,path:hsa04612,Antigen processing and presentation;hsa:3119,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3119,path:hsa04659,Th17 cell differentiation;hsa:3119,path:hsa04672,Intestinal immune network for IgA production;hsa:3119,path:hsa05310,Asthma;hsa:3119,path:hsa05322,Systemic lupus erythematosus;hsa:3119,path:hsa05323,Rheumatoid arthritis;hsa:3119,path:hsa05320,Autoimmune thyroid disease;hsa:3119,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3119,path:hsa05330,Allograft rejection;hsa:3119,path:hsa05332,Graft-versus-host disease;hsa:3119,path:hsa05416,Viral myocarditis;hsa:3119,path:hsa04940,Type I diabetes mellitus;hsa:3119,path:hsa05150,Staphylococcus aureus infection;hsa:3119,path:hsa05152,Tuberculosis;hsa:3119,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3119,path:hsa05164,Influenza A;hsa:3119,path:hsa05168,Herpes simplex virus 1 infection;hsa:3119,path:hsa05169,Epstein-Barr virus infection;hsa:3119,path:hsa05145,Toxoplasmosis;hsa:3119,path:hsa05140,Leishmaniasis;hsa:3113,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3113,path:hsa04145,Phagosome;hsa:3113,path:hsa04640,Hematopoietic cell lineage;hsa:3113,path:hsa04612,Antigen processing and presentation;hsa:3113,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3113,path:hsa04659,Th17 cell differentiation;hsa:3113,path:hsa04672,Intestinal immune network for IgA production;hsa:3113,path:hsa05310,Asthma;hsa:3113,path:hsa05322,Systemic lupus erythematosus;hsa:3113,path:hsa05323,Rheumatoid arthritis;hsa:3113,path:hsa05320,Autoimmune thyroid disease;hsa:3113,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3113,path:hsa05330,Allograft rejection;hsa:3113,path:hsa05332,Graft-versus-host disease;hsa:3113,path:hsa05416,Viral myocarditis;hsa:3113,path:hsa04940,Type I diabetes mellitus;hsa:3113,path:hsa05150,Staphylococcus aureus infection;hsa:3113,path:hsa05152,Tuberculosis;hsa:3113,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3113,path:hsa05164,Influenza A;hsa:3113,path:hsa05168,Herpes simplex virus 1 infection;hsa:3113,path:hsa05169,Epstein-Barr virus infection;hsa:3113,path:hsa05145,Toxoplasmosis;hsa:3113,path:hsa05140,Leishmaniasis;hsa:3125,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3125,path:hsa04145,Phagosome;hsa:3125,path:hsa04640,Hematopoietic cell lineage;hsa:3125,path:hsa04612,Antigen processing and presentation;hsa:3125,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3125,path:hsa04659,Th17 cell differentiation;hsa:3125,path:hsa04672,Intestinal immune network for IgA production;hsa:3125,path:hsa05310,Asthma;hsa:3125,path:hsa05322,Systemic lupus erythematosus;hsa:3125,path:hsa05323,Rheumatoid arthritis;hsa:3125,path:hsa05320,Autoimmune thyroid disease;hsa:3125,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3125,path:hsa05330,Allograft rejection;hsa:3125,path:hsa05332,Graft-versus-host disease;hsa:3125,path:hsa05416,Viral myocarditis;hsa:3125,path:hsa04940,Type I diabetes mellitus;hsa:3125,path:hsa05150,Staphylococcus aureus infection;hsa:3125,path:hsa05152,Tuberculosis;hsa:3125,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3125,path:hsa05164,Influenza A;hsa:3125,path:hsa05168,Herpes simplex virus 1 infection;hsa:3125,path:hsa05169,Epstein-Barr virus infection;hsa:3125,path:hsa05145,Toxoplasmosis;hsa:3125,path:hsa05140,Leishmaniasis;hsa:3126,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3126,path:hsa04145,Phagosome;hsa:3126,path:hsa04640,Hematopoietic cell lineage;hsa:3126,path:hsa04612,Antigen processing and presentation;hsa:3126,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3126,path:hsa04659,Th17 cell differentiation;hsa:3126,path:hsa04672,Intestinal immune network for IgA production;hsa:3126,path:hsa05310,Asthma;hsa:3126,path:hsa05322,Systemic lupus erythematosus;hsa:3126,path:hsa05323,Rheumatoid arthritis;hsa:3126,path:hsa05320,Autoimmune thyroid disease;hsa:3126,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3126,path:hsa05330,Allograft rejection;hsa:3126,path:hsa05332,Graft-versus-host disease;hsa:3126,path:hsa05416,Viral myocarditis;hsa:3126,path:hsa04940,Type I diabetes mellitus;hsa:3126,path:hsa05150,Staphylococcus aureus infection;hsa:3126,path:hsa05152,Tuberculosis;hsa:3126,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3126,path:hsa05164,Influenza A;hsa:3126,path:hsa05168,Herpes simplex virus 1 infection;hsa:3126,path:hsa05169,Epstein-Barr virus infection;hsa:3126,path:hsa05145,Toxoplasmosis;hsa:3126,path:hsa05140,Leishmaniasis;hsa:3107,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3107,path:hsa04144,Endocytosis;hsa:3107,path:hsa04145,Phagosome;hsa:3107,path:hsa04218,Cellular senescence;hsa:3107,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3107,path:hsa04612,Antigen processing and presentation;hsa:3107,path:hsa05203,Viral carcinogenesis;hsa:3107,path:hsa05320,Autoimmune thyroid disease;hsa:3107,path:hsa05330,Allograft rejection;hsa:3107,path:hsa05332,Graft-versus-host disease;hsa:3107,path:hsa05416,Viral myocarditis;hsa:3107,path:hsa04940,Type I diabetes mellitus;hsa:3107,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3107,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3107,path:hsa05168,Herpes simplex virus 1 infection;hsa:3107,path:hsa05163,Human cytomegalovirus infection;hsa:3107,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3107,path:hsa05169,Epstein-Barr virus infection;hsa:3107,path:hsa05165,Human papillomavirus infection;hsa:3135,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3135,path:hsa04144,Endocytosis;hsa:3135,path:hsa04145,Phagosome;hsa:3135,path:hsa04218,Cellular senescence;hsa:3135,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3135,path:hsa04612,Antigen processing and presentation;hsa:3135,path:hsa05203,Viral carcinogenesis;hsa:3135,path:hsa05320,Autoimmune thyroid disease;hsa:3135,path:hsa05330,Allograft rejection;hsa:3135,path:hsa05332,Graft-versus-host disease;hsa:3135,path:hsa05416,Viral myocarditis;hsa:3135,path:hsa04940,Type I diabetes mellitus;hsa:3135,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3135,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3135,path:hsa05168,Herpes simplex virus 1 infection;hsa:3135,path:hsa05163,Human cytomegalovirus infection;hsa:3135,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3135,path:hsa05169,Epstein-Barr virus infection;hsa:3135,path:hsa05165,Human papillomavirus infection;hsa:3127,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3127,path:hsa04145,Phagosome;hsa:3127,path:hsa04640,Hematopoietic cell lineage;hsa:3127,path:hsa04612,Antigen processing and presentation;hsa:3127,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3127,path:hsa04659,Th17 cell differentiation;hsa:3127,path:hsa04672,Intestinal immune network for IgA production;hsa:3127,path:hsa05310,Asthma;hsa:3127,path:hsa05322,Systemic lupus erythematosus;hsa:3127,path:hsa05323,Rheumatoid arthritis;hsa:3127,path:hsa05320,Autoimmune thyroid disease;hsa:3127,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3127,path:hsa05330,Allograft rejection;hsa:3127,path:hsa05332,Graft-versus-host disease;hsa:3127,path:hsa05416,Viral myocarditis;hsa:3127,path:hsa04940,Type I diabetes mellitus;hsa:3127,path:hsa05150,Staphylococcus aureus infection;hsa:3127,path:hsa05152,Tuberculosis;hsa:3127,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3127,path:hsa05164,Influenza A;hsa:3127,path:hsa05168,Herpes simplex virus 1 infection;hsa:3127,path:hsa05169,Epstein-Barr virus infection;hsa:3127,path:hsa05145,Toxoplasmosis;hsa:3127,path:hsa05140,Leishmaniasis;hsa:3118,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3118,path:hsa04145,Phagosome;hsa:3118,path:hsa04640,Hematopoietic cell lineage;hsa:3118,path:hsa04612,Antigen processing and presentation;hsa:3118,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3118,path:hsa04659,Th17 cell differentiation;hsa:3118,path:hsa04672,Intestinal immune network for IgA production;hsa:3118,path:hsa05310,Asthma;hsa:3118,path:hsa05322,Systemic lupus erythematosus;hsa:3118,path:hsa05323,Rheumatoid arthritis;hsa:3118,path:hsa05320,Autoimmune thyroid disease;hsa:3118,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3118,path:hsa05330,Allograft rejection;hsa:3118,path:hsa05332,Graft-versus-host disease;hsa:3118,path:hsa05416,Viral myocarditis;hsa:3118,path:hsa04940,Type I diabetes mellitus;hsa:3118,path:hsa05150,Staphylococcus aureus infection;hsa:3118,path:hsa05152,Tuberculosis;hsa:3118,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3118,path:hsa05164,Influenza A;hsa:3118,path:hsa05168,Herpes simplex virus 1 infection;hsa:3118,path:hsa05169,Epstein-Barr virus infection;hsa:3118,path:hsa05145,Toxoplasmosis;hsa:3118,path:hsa05140,Leishmaniasis;hsa:3117,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3117,path:hsa04145,Phagosome;hsa:3117,path:hsa04640,Hematopoietic cell lineage;hsa:3117,path:hsa04612,Antigen processing and presentation;hsa:3117,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3117,path:hsa04659,Th17 cell differentiation;hsa:3117,path:hsa04672,Intestinal immune network for IgA production;hsa:3117,path:hsa05310,Asthma;hsa:3117,path:hsa05322,Systemic lupus erythematosus;hsa:3117,path:hsa05323,Rheumatoid arthritis;hsa:3117,path:hsa05320,Autoimmune thyroid disease;hsa:3117,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3117,path:hsa05330,Allograft rejection;hsa:3117,path:hsa05332,Graft-versus-host disease;hsa:3117,path:hsa05416,Viral myocarditis;hsa:3117,path:hsa04940,Type I diabetes mellitus;hsa:3117,path:hsa05150,Staphylococcus aureus infection;hsa:3117,path:hsa05152,Tuberculosis;hsa:3117,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3117,path:hsa05164,Influenza A;hsa:3117,path:hsa05168,Herpes simplex virus 1 infection;hsa:3117,path:hsa05169,Epstein-Barr virus infection;hsa:3117,path:hsa05145,Toxoplasmosis;hsa:3117,path:hsa05140,Leishmaniasis
TENX_HUMAN	P22105	TNXB	Tenascin-X	3.674956981	2.707617038	3.426156848	25.95675577	3.1912870095	14.691456309	3.1912870095	14.691456309	0.217220603756281	0.021228	-1	4.60361486298965	0.021359	1	GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0098633,collagen fibril binding;GO:0005201,extracellular matrix structural constituent;GO:0008201,heparin binding;GO:0005178,integrin binding;GO:0005518,collagen binding	GO:0030036,actin cytoskeleton organization;GO:0007155,cell adhesion;GO:0030199,collagen fibril organization;GO:0032963,collagen metabolic process;GO:0048251,elastic fiber assembly;GO:0098609,cell-cell adhesion;GO:0007160,cell-matrix adhesion;GO:0006631,fatty acid metabolic process;GO:0043506,regulation of JUN kinase activity;GO:0006641,triglyceride metabolic process	hsa:7148,path:hsa04151,PI3K-Akt signaling pathway;hsa:7148,path:hsa04512,ECM-receptor interaction;hsa:7148,path:hsa04510,Focal adhesion;hsa:7148,path:hsa05206,MicroRNAs in cancer;hsa:7148,path:hsa05165,Human papillomavirus infection
BACH_HUMAN	O00154	ACOT7	Cytosolic acyl coenzyme A thioester hydrolase	1.033187836	0.785141007	0.905380679	0.674464745	0.9091644215	0.789922712	0.9091644215	0.789922712	1.150953641019	0.387306	0	0.868844725244234	0.387013	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0047617,acyl-CoA hydrolase activity;GO:0052689,carboxylic ester hydrolase activity;GO:0000062,fatty-acyl-CoA binding;GO:0036042,long-chain fatty acyl-CoA binding;GO:0102991,myristoyl-CoA hydrolase activity;GO:0016290,palmitoyl-CoA hydrolase activity;GO:0042803,protein homodimerization activity;GO:0016790,thiolester hydrolase activity	GO:0006637,acyl-CoA metabolic process;GO:0015937,coenzyme A biosynthetic process;GO:0006631,fatty acid metabolic process;GO:0036116,long-chain fatty-acyl-CoA catabolic process;GO:0051792,medium-chain fatty acid biosynthetic process;GO:0036114,medium-chain fatty-acyl-CoA catabolic process;GO:1900535,palmitic acid biosynthetic process	hsa:11332,path:hsa00062,Fatty acid elongation;hsa:11332,path:hsa01040,Biosynthesis of unsaturated fatty acids
ALS_HUMAN	P35858	IGFALS	Insulin-like growth factor-binding protein complex acid labile subunit	0.200016011	0.098290728	0.248853454	0.710702133	0.1491533695	0.4797777935	0.1491533695	0.4797777935	0.310880102248834	0.069282	0	3.21667418649902	0.069540	0	GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0042567,insulin-like growth factor ternary complex	GO:0005520,insulin-like growth factor binding	GO:0007155,cell adhesion;GO:0044267,cellular protein metabolic process;GO:0007165,signal transduction	hsa:3483,path:hsa04935,Growth hormone synthesis, secretion and action
CFAB_HUMAN	P00751	CFB	Complement factor B	2.70757414	4.058639549	5.058110511	35.08164435	3.3831068445	20.0698774305	3.3831068445	20.0698774305	0.168566392904758	0.007834	-1	5.93238060545681	0.007899	1	GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane	GO:0001848,complement binding;GO:0004252,serine-type endopeptidase activity	GO:0006956,complement activation;GO:0006957,complement activation, alternative pathway;GO:0030449,regulation of complement activation	hsa:629,path:hsa04610,Complement and coagulation cascades;hsa:629,path:hsa05150,Staphylococcus aureus infection
PPIB_HUMAN	P23284	PPIB	Peptidyl-prolyl cis-trans isomerase B	67.04291723	202.9269775	11.38191852	4.305978082	134.984947365	7.843948301	134.984947365	7.843948301	17.208801254821	0.005142	1	0.0581098000489634	0.005056	-1	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0043231,intracellular membrane-bounded organelle;GO:0042470,melanosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0032991,protein-containing complex	GO:0016018,cyclosporin A binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity;GO:0003723,RNA binding;GO:0070063,RNA polymerase binding;GO:0051082,unfolded protein binding	GO:0060348,bone development;GO:0061077,chaperone-mediated protein folding;GO:0030199,collagen fibril organization;GO:0030593,neutrophil chemotaxis;GO:0044829,positive regulation by host of viral genome replication;GO:0044794,positive regulation by host of viral process;GO:0040018,positive regulation of multicellular organism growth;GO:0006457,protein folding;GO:0000413,protein peptidyl-prolyl isomerization;GO:0050821,protein stabilization	
RASH_HUMAN	P01112	HRAS	GTPase HRas	0.977424537	2.053930608	0.11515439	0.087576306	1.5156775725	0.101365348	1.5156775725	0.101365348	14.9526204211325	0.007189	1	0.0668779098135003	0.007078	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0098978,glutamatergic synapse;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane	GO:0003925,G protein activity;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0008022,protein C-terminus binding;GO:0044877,protein-containing complex binding	GO:0009887,animal organ morphogenesis;GO:0007050,cell cycle arrest;GO:0007166,cell surface receptor signaling pathway;GO:0071480,cellular response to gamma radiation;GO:0090398,cellular senescence;GO:0006935,chemotaxis;GO:0042832,defense response to protozoan;GO:0006897,endocytosis;GO:0048013,ephrin receptor signaling pathway;GO:0097193,intrinsic apoptotic signaling pathway;GO:0001889,liver development;GO:0000165,MAPK cascade;GO:0008285,negative regulation of cell population proliferation;GO:0010629,negative regulation of gene expression;GO:0034260,negative regulation of GTPase activity;GO:0043524,negative regulation of neuron apoptotic process;GO:2000251,positive regulation of actin cytoskeleton reorganization;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0045740,positive regulation of DNA replication;GO:0050679,positive regulation of epithelial cell proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0043547,positive regulation of GTPase activity;GO:0032729,positive regulation of interferon-gamma production;GO:0046330,positive regulation of JNK cascade;GO:0043406,positive regulation of MAP kinase activity;GO:0043410,positive regulation of MAPK cascade;GO:2000630,positive regulation of miRNA metabolic process;GO:0010863,positive regulation of phospholipase C activity;GO:0001934,positive regulation of protein phosphorylation;GO:0090314,positive regulation of protein targeting to membrane;GO:0046579,positive regulation of Ras protein signal transduction;GO:1900029,positive regulation of ruffle assembly;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0090303,positive regulation of wound healing;GO:0007265,Ras protein signal transduction;GO:0048169,regulation of long-term neuronal synaptic plasticity;GO:0098696,regulation of neurotransmitter receptor localization to postsynaptic specialization membrane;GO:0035900,response to isolation stress;GO:0007165,signal transduction;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0042088,T-helper 1 type immune response	hsa:3265,path:hsa04014,Ras signaling pathway;hsa:3265,path:hsa04015,Rap1 signaling pathway;hsa:3265,path:hsa04010,MAPK signaling pathway;hsa:3265,path:hsa04012,ErbB signaling pathway;hsa:3265,path:hsa04370,VEGF signaling pathway;hsa:3265,path:hsa04371,Apelin signaling pathway;hsa:3265,path:hsa04630,Jak-STAT signaling pathway;hsa:3265,path:hsa04068,FoxO signaling pathway;hsa:3265,path:hsa04072,Phospholipase D signaling pathway;hsa:3265,path:hsa04071,Sphingolipid signaling pathway;hsa:3265,path:hsa04151,PI3K-Akt signaling pathway;hsa:3265,path:hsa04150,mTOR signaling pathway;hsa:3265,path:hsa04144,Endocytosis;hsa:3265,path:hsa04140,Autophagy - animal;hsa:3265,path:hsa04137,Mitophagy - animal;hsa:3265,path:hsa04210,Apoptosis;hsa:3265,path:hsa04218,Cellular senescence;hsa:3265,path:hsa04510,Focal adhesion;hsa:3265,path:hsa04540,Gap junction;hsa:3265,path:hsa04550,Signaling pathways regulating pluripotency of stem cells;hsa:3265,path:hsa04810,Regulation of actin cytoskeleton;hsa:3265,path:hsa04625,C-type lectin receptor signaling pathway;hsa:3265,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3265,path:hsa04660,T cell receptor signaling pathway;hsa:3265,path:hsa04662,B cell receptor signaling pathway;hsa:3265,path:hsa04664,Fc epsilon RI signaling pathway;hsa:3265,path:hsa04062,Chemokine signaling pathway;hsa:3265,path:hsa04910,Insulin signaling pathway;hsa:3265,path:hsa04929,GnRH secretion;hsa:3265,path:hsa04912,GnRH signaling pathway;hsa:3265,path:hsa04915,Estrogen signaling pathway;hsa:3265,path:hsa04917,Prolactin signaling pathway;hsa:3265,path:hsa04921,Oxytocin signaling pathway;hsa:3265,path:hsa04926,Relaxin signaling pathway;hsa:3265,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:3265,path:hsa04919,Thyroid hormone signaling pathway;hsa:3265,path:hsa04916,Melanogenesis;hsa:3265,path:hsa04725,Cholinergic synapse;hsa:3265,path:hsa04726,Serotonergic synapse;hsa:3265,path:hsa04720,Long-term potentiation;hsa:3265,path:hsa04730,Long-term depression;hsa:3265,path:hsa04722,Neurotrophin signaling pathway;hsa:3265,path:hsa04360,Axon guidance;hsa:3265,path:hsa04211,Longevity regulating pathway;hsa:3265,path:hsa04213,Longevity regulating pathway - multiple species;hsa:3265,path:hsa04714,Thermogenesis;hsa:3265,path:hsa05200,Pathways in cancer;hsa:3265,path:hsa05206,MicroRNAs in cancer;hsa:3265,path:hsa05205,Proteoglycans in cancer;hsa:3265,path:hsa05203,Viral carcinogenesis;hsa:3265,path:hsa05230,Central carbon metabolism in cancer;hsa:3265,path:hsa05231,Choline metabolism in cancer;hsa:3265,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:3265,path:hsa05210,Colorectal cancer;hsa:3265,path:hsa05225,Hepatocellular carcinoma;hsa:3265,path:hsa05226,Gastric cancer;hsa:3265,path:hsa05214,Glioma;hsa:3265,path:hsa05216,Thyroid cancer;hsa:3265,path:hsa05221,Acute myeloid leukemia;hsa:3265,path:hsa05220,Chronic myeloid leukemia;hsa:3265,path:hsa05218,Melanoma;hsa:3265,path:hsa05211,Renal cell carcinoma;hsa:3265,path:hsa05219,Bladder cancer;hsa:3265,path:hsa05215,Prostate cancer;hsa:3265,path:hsa05213,Endometrial cancer;hsa:3265,path:hsa05224,Breast cancer;hsa:3265,path:hsa05223,Non-small cell lung cancer;hsa:3265,path:hsa05034,Alcoholism;hsa:3265,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:3265,path:hsa05132,Salmonella infection;hsa:3265,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3265,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3265,path:hsa05161,Hepatitis B;hsa:3265,path:hsa05160,Hepatitis C;hsa:3265,path:hsa05163,Human cytomegalovirus infection;hsa:3265,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3265,path:hsa05165,Human papillomavirus infection;hsa:3265,path:hsa01521,EGFR tyrosine kinase inhibitor resistance;hsa:3265,path:hsa01522,Endocrine resistance
THIK_HUMAN	P09110	ACAA1	3-ketoacyl-CoA thiolase, peroxisomal	0.848177173	1.626623494	3.795360925	1.315520412	1.2374003335	2.5554406685	1.2374003335	2.5554406685	0.484221899084956	0.210713	0	2.06516888618569	0.211045	0	GO:0005829,cytosol;GO:0005576,extracellular region;GO:0016020,membrane;GO:0005782,peroxisomal matrix;GO:0005777,peroxisome;GO:0035580,specific granule lumen	GO:0008775,acetate CoA-transferase activity;GO:0003985,acetyl-CoA C-acetyltransferase activity;GO:0003988,acetyl-CoA C-acyltransferase activity;GO:0050633,acetyl-CoA C-myristoyltransferase activity;GO:0016401,palmitoyl-CoA oxidase activity;GO:0016747,transferase activity, transferring acyl groups other than amino-acyl groups	GO:0036109,alpha-linolenic acid metabolic process;GO:0008206,bile acid metabolic process;GO:0006635,fatty acid beta-oxidation;GO:0033540,fatty acid beta-oxidation using acyl-CoA oxidase;GO:0043312,neutrophil degranulation;GO:0010124,phenylacetate catabolic process;GO:0008104,protein localization;GO:0000038,very long-chain fatty acid metabolic process	hsa:30,path:hsa00071,Fatty acid degradation;hsa:30,path:hsa00592,alpha-Linolenic acid metabolism;hsa:30,path:hsa01040,Biosynthesis of unsaturated fatty acids;hsa:30,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:30,path:hsa04146,Peroxisome;hsa:30,path:hsa03320,PPAR signaling pathway
KAPCB_HUMAN	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.081390759	0.121458833	0.347793104	0.147752969	0.101424796	0.2477730365	0.101424796	0.2477730365	0.40934557461421	0.144421	0	2.44292368603827	0.144750	0	GO:0005952,cAMP-dependent protein kinase complex;GO:0005813,centrosome;GO:0097546,ciliary base;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0045202,synapse	GO:0004679,AMP-activated protein kinase activity;GO:0005524,ATP binding;GO:0004691,cAMP-dependent protein kinase activity;GO:0000287,magnesium ion binding;GO:0106310,protein serine kinase activity;GO:0106311,protein threonine kinase activity;GO:0031625,ubiquitin protein ligase binding;GO:0004674,protein serine/threonine kinase activity	GO:0034199,activation of protein kinase A activity;GO:0002250,adaptive immune response;GO:0007188,adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007596,blood coagulation;GO:0071377,cellular response to glucagon stimulus;GO:0007268,chemical synaptic transmission;GO:0034380,high-density lipoprotein particle assembly;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0051447,negative regulation of meiotic cell cycle;GO:1901621,negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning;GO:0001843,neural tube closure;GO:0010737,protein kinase A signaling;GO:0006468,protein phosphorylation;GO:0070613,regulation of protein processing;GO:0003091,renal water homeostasis;GO:0097338,response to clozapine;GO:0007165,signal transduction;GO:0002223,stimulatory C-type lectin receptor signaling pathway	hsa:5567,path:hsa04014,Ras signaling pathway;hsa:5567,path:hsa04010,MAPK signaling pathway;hsa:5567,path:hsa04310,Wnt signaling pathway;hsa:5567,path:hsa04340,Hedgehog signaling pathway;hsa:5567,path:hsa04371,Apelin signaling pathway;hsa:5567,path:hsa04020,Calcium signaling pathway;hsa:5567,path:hsa04024,cAMP signaling pathway;hsa:5567,path:hsa04140,Autophagy - animal;hsa:5567,path:hsa04114,Oocyte meiosis;hsa:5567,path:hsa04530,Tight junction;hsa:5567,path:hsa04540,Gap junction;hsa:5567,path:hsa04611,Platelet activation;hsa:5567,path:hsa04062,Chemokine signaling pathway;hsa:5567,path:hsa04911,Insulin secretion;hsa:5567,path:hsa04910,Insulin signaling pathway;hsa:5567,path:hsa04922,Glucagon signaling pathway;hsa:5567,path:hsa04923,Regulation of lipolysis in adipocytes;hsa:5567,path:hsa04912,GnRH signaling pathway;hsa:5567,path:hsa04913,Ovarian steroidogenesis;hsa:5567,path:hsa04915,Estrogen signaling pathway;hsa:5567,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:5567,path:hsa04921,Oxytocin signaling pathway;hsa:5567,path:hsa04926,Relaxin signaling pathway;hsa:5567,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:5567,path:hsa04918,Thyroid hormone synthesis;hsa:5567,path:hsa04919,Thyroid hormone signaling pathway;hsa:5567,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:5567,path:hsa04916,Melanogenesis;hsa:5567,path:hsa04924,Renin secretion;hsa:5567,path:hsa04925,Aldosterone synthesis and secretion;hsa:5567,path:hsa04927,Cortisol synthesis and secretion;hsa:5567,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:5567,path:hsa04270,Vascular smooth muscle contraction;hsa:5567,path:hsa04970,Salivary secretion;hsa:5567,path:hsa04971,Gastric acid secretion;hsa:5567,path:hsa04976,Bile secretion;hsa:5567,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:5567,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:5567,path:hsa04724,Glutamatergic synapse;hsa:5567,path:hsa04727,GABAergic synapse;hsa:5567,path:hsa04725,Cholinergic synapse;hsa:5567,path:hsa04728,Dopaminergic synapse;hsa:5567,path:hsa04726,Serotonergic synapse;hsa:5567,path:hsa04720,Long-term potentiation;hsa:5567,path:hsa04723,Retrograde endocannabinoid signaling;hsa:5567,path:hsa04740,Olfactory transduction;hsa:5567,path:hsa04742,Taste transduction;hsa:5567,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:5567,path:hsa04211,Longevity regulating pathway;hsa:5567,path:hsa04213,Longevity regulating pathway - multiple species;hsa:5567,path:hsa04713,Circadian entrainment;hsa:5567,path:hsa04714,Thermogenesis;hsa:5567,path:hsa05200,Pathways in cancer;hsa:5567,path:hsa05205,Proteoglycans in cancer;hsa:5567,path:hsa05203,Viral carcinogenesis;hsa:5567,path:hsa05012,Parkinson disease;hsa:5567,path:hsa05020,Prion diseases;hsa:5567,path:hsa05030,Cocaine addiction;hsa:5567,path:hsa05031,Amphetamine addiction;hsa:5567,path:hsa05032,Morphine addiction;hsa:5567,path:hsa05034,Alcoholism;hsa:5567,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:5567,path:hsa04934,Cushing syndrome;hsa:5567,path:hsa05110,Vibrio cholerae infection;hsa:5567,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:5567,path:hsa05163,Human cytomegalovirus infection;hsa:5567,path:hsa05165,Human papillomavirus infection;hsa:5567,path:hsa05146,Amoebiasis;hsa:5567,path:hsa01522,Endocrine resistance
PGES2_HUMAN	Q9H7Z7	PTGES2	Prostaglandin E synthase 2	0.464176466	0.810891894	0.672530661	0.62326782	0.63753418	0.6478992405	0.63753418	0.6478992405	0.984002048695101	0.438704	0	1.01625804674504	0.438519	0	GO:0035578,azurophil granule lumen;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm	GO:0036134,12-hydroxyheptadecatrienoic acid synthase activity;GO:0003677,DNA binding;GO:0043295,glutathione binding;GO:0020037,heme binding;GO:0016829,lyase activity;GO:0050220,prostaglandin-E synthase activity;GO:0015035,protein disulfide oxidoreductase activity	GO:0019371,cyclooxygenase pathway;GO:0006749,glutathione metabolic process;GO:0006629,lipid metabolic process;GO:0043312,neutrophil degranulation;GO:0045893,positive regulation of transcription, DNA-templated	hsa:80142,path:hsa00590,Arachidonic acid metabolism
NUP43_HUMAN	Q8NFH3	NUP43	Nucleoporin Nup43	0.149989062	0.037360791	0.169000401	2.55E-05	0.0936749265	0.0845129505	0.0936749265	0.0845129505	1.10840913665652	0.399516	0	0.902193934467619	0.399248	0	GO:0000777,condensed chromosome kinetochore;GO:0005829,cytosol;GO:0043657,host cell;GO:0005635,nuclear envelope;GO:0031080,nuclear pore outer ring;GO:0016607,nuclear speck;GO:0005654,nucleoplasm		GO:0051301,cell division;GO:0007059,chromosome segregation;GO:0075733,intracellular transport of virus;GO:0007084,mitotic nuclear envelope reassembly;GO:0007052,mitotic spindle organization;GO:0006406,mRNA export from nucleus;GO:0016925,protein sumoylation;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription	hsa:348995,path:hsa03013,RNA transport
AP1G2_HUMAN	O75843	AP1G2	AP-1 complex subunit gamma-like 2	0.149591607	0.150308889	0.220140652	0.249890976	0.149950248	0.235015814	0.149950248	0.235015814	0.63804322546567	0.351093	0	1.56729193272158	0.351340	0	GO:0030121,AP-1 adaptor complex;GO:0010008,endosome membrane;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005798,Golgi-associated vesicle;GO:0016020,membrane;GO:0030133,transport vesicle;GO:0030117,membrane coat	GO:0140312,cargo adaptor activity;GO:0035615,clathrin adaptor activity	GO:0006896,Golgi to vacuole transport;GO:0006886,intracellular protein transport;GO:0006892,post-Golgi vesicle-mediated transport;GO:0006898,receptor-mediated endocytosis;GO:0016192,vesicle-mediated transport;GO:0016032,viral process	hsa:8906,path:hsa04142,Lysosome;hsa:8906,path:hsa05170,Human immunodeficiency virus 1 infection
PDIA6_HUMAN	Q15084	PDIA6	Protein disulfide-isomerase A6	20.2110825	12.14940506	34.07766912	17.90467147	16.18024378	25.991170295	16.18024378	25.991170295	0.622528481647963	0.337246	0	1.60635220633246	0.337505	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0034663,endoplasmic reticulum chaperone complex;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0042470,melanosome;GO:0005886,plasma membrane	GO:0015037,peptide disulfide oxidoreductase activity;GO:0003756,protein disulfide isomerase activity	GO:0044267,cellular protein metabolic process;GO:0036498,IRE1-mediated unfolded protein response;GO:0043687,post-translational protein modification;GO:0006457,protein folding	hsa:10130,path:hsa04141,Protein processing in endoplasmic reticulum
MON2_HUMAN	Q7Z3U7	MON2	Protein MON2 homolog	0.698001762	0.729936706	1.481362653	0.798351602	0.713969234	1.1398571275	0.713969234	1.1398571275	0.626367302335441	0.340684	0	1.59650734684178	0.340940	0	GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0070062,extracellular exosome		GO:0006895,Golgi to endosome transport;GO:0015031,protein transport	
APOE_HUMAN	P02649	APOE	Apolipoprotein E	2.483538994	2.123789767	3.582311944	10.98218628	2.3036643805	7.282249112	2.3036643805	7.282249112	0.316339683670519	0.072897	0	3.16115887958446	0.073160	0	GO:0072562,blood microparticle;GO:0042627,chylomicron;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0030425,dendrite;GO:0034365,discoidal high-density lipoprotein particle;GO:0005769,early endosome;GO:0071682,endocytic vesicle lumen;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1903561,extracellular vesicle;GO:0098978,glutamatergic synapse;GO:0005794,Golgi apparatus;GO:0034364,high-density lipoprotein particle;GO:0034363,intermediate-density lipoprotein particle;GO:1990777,lipoprotein particle;GO:0034362,low-density lipoprotein particle;GO:0016020,membrane;GO:0043025,neuronal cell body;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0043083,synaptic cleft;GO:0034361,very-low-density lipoprotein particle	GO:0001540,amyloid-beta binding;GO:0016209,antioxidant activity;GO:0120020,cholesterol transfer activity;GO:0043395,heparan sulfate proteoglycan binding;GO:0008201,heparin binding;GO:0042802,identical protein binding;GO:0008289,lipid binding;GO:0005319,lipid transporter activity;GO:0071813,lipoprotein particle binding;GO:0050750,low-density lipoprotein particle receptor binding;GO:0046911,metal chelating activity;GO:0060228,phosphatidylcholine-sterol O-acyltransferase activator activity;GO:0005543,phospholipid binding;GO:0046983,protein dimerization activity;GO:0042803,protein homodimerization activity;GO:0044877,protein-containing complex binding;GO:0005102,signaling receptor binding;GO:0005198,structural molecule activity;GO:0048156,tau protein binding;GO:0070326,very-low-density lipoprotein particle receptor binding	GO:0097113,AMPA glutamate receptor clustering;GO:0042982,amyloid precursor protein metabolic process;GO:0048844,artery morphogenesis;GO:0006874,cellular calcium ion homeostasis;GO:0044267,cellular protein metabolic process;GO:0019934,cGMP-mediated signaling;GO:0006707,cholesterol catabolic process;GO:0033344,cholesterol efflux;GO:0042632,cholesterol homeostasis;GO:0008203,cholesterol metabolic process;GO:0034378,chylomicron assembly;GO:0034382,chylomicron remnant clearance;GO:0034371,chylomicron remodeling;GO:0007010,cytoskeleton organization;GO:0055089,fatty acid homeostasis;GO:0007186,G protein-coupled receptor signaling pathway;GO:0010467,gene expression;GO:0034380,high-density lipoprotein particle assembly;GO:0034384,high-density lipoprotein particle clearance;GO:0034375,high-density lipoprotein particle remodeling;GO:0071831,intermediate-density lipoprotein particle clearance;GO:0030522,intracellular receptor signaling pathway;GO:0046907,intracellular transport;GO:0010877,lipid transport involved in lipid storage;GO:0042158,lipoprotein biosynthetic process;GO:0042159,lipoprotein catabolic process;GO:0035641,locomotory exploration behavior;GO:0015909,long-chain fatty acid transport;GO:0007616,long-term memory;GO:0034374,low-density lipoprotein particle remodeling;GO:0051651,maintenance of location in cell;GO:1905907,negative regulation of amyloid fibril formation;GO:1902430,negative regulation of amyloid-beta formation;GO:0030195,negative regulation of blood coagulation;GO:0043537,negative regulation of blood vessel endothelial cell migration;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0032269,negative regulation of cellular protein metabolic process;GO:0045541,negative regulation of cholesterol biosynthetic process;GO:0090370,negative regulation of cholesterol efflux;GO:0061000,negative regulation of dendritic spine development;GO:1902951,negative regulation of dendritic spine maintenance;GO:0010596,negative regulation of endothelial cell migration;GO:0001937,negative regulation of endothelial cell proliferation;GO:0010629,negative regulation of gene expression;GO:0050728,negative regulation of inflammatory response;GO:0051055,negative regulation of lipid biosynthetic process;GO:1903001,negative regulation of lipid transport across blood-brain barrier;GO:1900272,negative regulation of long-term synaptic potentiation;GO:0043407,negative regulation of MAP kinase activity;GO:0043524,negative regulation of neuron apoptotic process;GO:1901215,negative regulation of neuron death;GO:0010977,negative regulation of neuron projection development;GO:1902999,negative regulation of phospholipid efflux;GO:0010544,negative regulation of platelet activation;GO:1901627,negative regulation of postsynaptic membrane organization;GO:0050709,negative regulation of protein secretion;GO:0090209,negative regulation of triglyceride metabolic process;GO:0031175,neuron projection development;GO:0007263,nitric oxide mediated signal transduction;GO:0097114,NMDA glutamate receptor clustering;GO:0033700,phospholipid efflux;GO:0044794,positive regulation by host of viral process;GO:1905908,positive regulation of amyloid fibril formation;GO:1900223,positive regulation of amyloid-beta clearance;GO:1902004,positive regulation of amyloid-beta formation;GO:0010875,positive regulation of cholesterol efflux;GO:0010873,positive regulation of cholesterol esterification;GO:0060999,positive regulation of dendritic spine development;GO:1902952,positive regulation of dendritic spine maintenance;GO:0045807,positive regulation of endocytosis;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:1905855,positive regulation of heparan sulfate binding;GO:1905860,positive regulation of heparan sulfate proteoglycan binding;GO:0046889,positive regulation of lipid biosynthetic process;GO:1903002,positive regulation of lipid transport across blood-brain barrier;GO:0032805,positive regulation of low-density lipoprotein particle receptor catabolic process;GO:0051044,positive regulation of membrane protein ectodomain proteolysis;GO:1902998,positive regulation of neurofibrillary tangle assembly;GO:1901216,positive regulation of neuron death;GO:0010976,positive regulation of neuron projection development;GO:0051000,positive regulation of nitric-oxide synthase activity;GO:1902995,positive regulation of phospholipid efflux;GO:1901631,positive regulation of presynaptic membrane organization;GO:0045893,positive regulation of transcription, DNA-templated;GO:0043687,post-translational protein modification;GO:0017038,protein import;GO:0006898,receptor-mediated endocytosis;GO:1905906,regulation of amyloid fibril formation;GO:1902991,regulation of amyloid precursor protein catabolic process;GO:1900221,regulation of amyloid-beta clearance;GO:0030516,regulation of axon extension;GO:2000822,regulation of behavioral fear response;GO:0032489,regulation of Cdc42 protein signal transduction;GO:1905890,regulation of cellular response to very-low-density lipoprotein particle stimulus;GO:0090181,regulation of cholesterol metabolic process;GO:0045088,regulation of innate immune response;GO:1901214,regulation of neuron death;GO:0048168,regulation of neuronal synaptic plasticity;GO:0061136,regulation of proteasomal protein catabolic process;GO:0051246,regulation of protein metabolic process;GO:0043254,regulation of protein-containing complex assembly;GO:1902947,regulation of tau-protein kinase activity;GO:0006357,regulation of transcription by RNA polymerase II;GO:0061771,response to caloric restriction;GO:0002021,response to dietary excess;GO:0000302,response to reactive oxygen species;GO:0001523,retinoid metabolic process;GO:0043691,reverse cholesterol transport;GO:0007271,synaptic transmission, cholinergic;GO:0070328,triglyceride homeostasis;GO:0006641,triglyceride metabolic process;GO:0071830,triglyceride-rich lipoprotein particle clearance;GO:0042311,vasodilation;GO:0034447,very-low-density lipoprotein particle clearance;GO:0034372,very-low-density lipoprotein particle remodeling;GO:0019068,virion assembly;GO:0006869,lipid transport;GO:0042157,lipoprotein metabolic process	hsa:348,path:hsa04979,Cholesterol metabolism;hsa:348,path:hsa05010,Alzheimer disease
CH082_HUMAN	Q6P1X6	C8orf82	UPF0598 protein C8orf82	0.175262614	0.193125738	0.028697179	2.55E-05	0.184194176	0.0143613395	0.184194176	0.0143613395	12.8256960988911	0.010215	1	0.0779684776786862	0.010071	-1				
NID1_HUMAN	P14543	NID1	Nidogen-1	2.08723707	2.017216868	8.183935308	34.51141181	2.052226969	21.347673559	2.052226969	21.347673559	0.0961335184055594	0.000529	-1	10.4021991141663	0.000536	1	GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005886,plasma membrane	GO:0005509,calcium ion binding;GO:0005518,collagen binding;GO:0005201,extracellular matrix structural constituent;GO:0043236,laminin binding;GO:0043237,laminin-1 binding;GO:0043394,proteoglycan binding	GO:0071711,basement membrane organization;GO:0007160,cell-matrix adhesion;GO:0030198,extracellular matrix organization;GO:0032836,glomerular basement membrane development;GO:0010811,positive regulation of cell-substrate adhesion	
FCGBP_HUMAN	Q9Y6R7	FCGBP	IgGFc-binding protein	0.325972266	0.638338211	0.118589922	0.158326888	0.4821552385	0.138458405	0.4821552385	0.138458405	3.48231108469002	0.111330	0	0.287165613777729	0.110791	0	GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005615,extracellular space			
VTA1_HUMAN	Q9NP79	VTA1	Vacuolar protein sorting-associated protein VTA1 homolog	0.18592534	0.138609187	0.221290822	0.067316813	0.1622672635	0.1443038175	0.1622672635	0.1443038175	1.12448351201797	0.394836	0	0.889297165598654	0.394558	0	GO:0005829,cytosol;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0005771,multivesicular body;GO:0005654,nucleoplasm	GO:0008022,protein C-terminus binding	GO:0016197,endosomal transport;GO:1904903,ESCRT III complex disassembly;GO:0032511,late endosome to vacuole transport via multivesicular body sorting pathway;GO:0016236,macroautophagy;GO:0036258,multivesicular body assembly;GO:0071985,multivesicular body sorting pathway;GO:0015031,protein transport;GO:0046755,viral budding;GO:0019058,viral life cycle	hsa:51534,path:hsa04144,Endocytosis
ILK_HUMAN	Q13418	ILK	Integrin-linked protein kinase	3.585252187	3.081298411	3.771142573	9.72886138	3.333275299	6.7500019765	3.333275299	6.7500019765	0.493818418217466	0.219477	0	2.02503584943165	0.219808	0	GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0030017,sarcomere;GO:0005911,cell-cell junction;GO:0043034,costamere;GO:0043198,dendritic shaft;GO:0043025,neuronal cell body;GO:0032991,protein-containing complex;GO:0001725,stress fiber;GO:0043195,terminal bouton	GO:0005524,ATP binding;GO:0004672,protein kinase activity;GO:0019901,protein kinase binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0005178,integrin binding;GO:0017124,SH3 domain binding	GO:0034329,cell junction assembly;GO:0000902,cell morphogenesis;GO:0007160,cell-matrix adhesion;GO:0007229,integrin-mediated signaling pathway;GO:0070527,platelet aggregation;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:0042327,positive regulation of phosphorylation;GO:0001934,positive regulation of protein phosphorylation;GO:0009967,positive regulation of signal transduction;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0045893,positive regulation of transcription, DNA-templated;GO:0006468,protein phosphorylation;GO:0034446,substrate adhesion-dependent cell spreading;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0001658,branching involved in ureteric bud morphogenesis;GO:0007569,cell aging;GO:0007050,cell cycle arrest;GO:0045197,establishment or maintenance of epithelial cell apical/basal polarity;GO:0010761,fibroblast migration;GO:0032288,myelin assembly;GO:0022011,myelination in peripheral nervous system;GO:0010667,negative regulation of cardiac muscle cell apoptotic process;GO:2000178,negative regulation of neural precursor cell proliferation;GO:0043524,negative regulation of neuron apoptotic process;GO:0006469,negative regulation of protein kinase activity;GO:0014912,negative regulation of smooth muscle cell migration;GO:0048662,negative regulation of smooth muscle cell proliferation;GO:0021675,nerve development;GO:0048812,neuron projection morphogenesis;GO:0003151,outflow tract morphogenesis;GO:0018105,peptidyl-serine phosphorylation;GO:0045773,positive regulation of axon extension;GO:0030513,positive regulation of BMP signaling pathway;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0001954,positive regulation of cell-matrix adhesion;GO:0050775,positive regulation of dendrite morphogenesis;GO:0043406,positive regulation of MAP kinase activity;GO:0045663,positive regulation of myoblast differentiation;GO:0045669,positive regulation of osteoblast differentiation;GO:0051897,positive regulation of protein kinase B signaling;GO:0043491,protein kinase B signaling;GO:0032956,regulation of actin cytoskeleton organization;GO:0097435,supramolecular fiber organization	hsa:3611,path:hsa04510,Focal adhesion;hsa:3611,path:hsa03320,PPAR signaling pathway;hsa:3611,path:hsa04360,Axon guidance;hsa:3611,path:hsa05213,Endometrial cancer;hsa:3611,path:hsa05131,Shigellosis;hsa:3611,path:hsa05100,Bacterial invasion of epithelial cells
TXLNA_HUMAN	P40222	TXLNA	Alpha-taxilin	0.160434231	0.333306197	0.167065397	0.815392601	0.246870214	0.491228999	0.246870214	0.491228999	0.502556271112976	0.227485	0	1.98982692581941	0.227813	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0016020,membrane	GO:0019905,syntaxin binding	GO:0042113,B cell activation;GO:0019221,cytokine-mediated signaling pathway;GO:0006887,exocytosis	
RS12_HUMAN	P25398	RPS12	40S ribosomal protein S12	6.527357555	15.58972723	2.217683727	1.496720603	11.0585423925	1.857202165	11.0585423925	1.857202165	5.95440959573725	0.047299	1	0.167942763076947	0.046919	-1	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005654,nucleoplasm	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6206,path:hsa03010,Ribosome
HS105_HUMAN	Q92598	HSPH1	Heat shock protein 105 kDa	7.886193269	2.946217994	5.248927769	7.597916391	5.4162056315	6.42342208	5.4162056315	6.42342208	0.843196284479565	0.490389	0	1.18596348016075	0.490317	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0071682,endocytic vesicle lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005874,microtubule;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0000774,adenyl-nucleotide exchange factor activity;GO:0043014,alpha-tubulin binding;GO:0005524,ATP binding;GO:0016887,ATPase activity	GO:0051085,chaperone cofactor-dependent protein refolding;GO:0045345,positive regulation of MHC class I biosynthetic process;GO:0051135,positive regulation of NK T cell activation;GO:0006898,receptor-mediated endocytosis;GO:1900034,regulation of cellular response to heat;GO:0006986,response to unfolded protein	hsa:10808,path:hsa04141,Protein processing in endoplasmic reticulum
PRKDC_HUMAN	P78527	PRKDC	DNA-dependent protein kinase catalytic subunit	20.13202195	21.63119697	31.20786227	31.69457807	20.88160946	31.45122017	20.88160946	31.45122017	0.663936386160245	0.373886	0	1.50616839330545	0.374112	0	GO:0000781,chromosome, telomeric region;GO:0005829,cytosol;GO:0005958,DNA-dependent protein kinase-DNA ligase 4 complex;GO:0016020,membrane;GO:0070419,nonhomologous end joining complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0032993,protein-DNA complex;GO:0032040,small-subunit processome;GO:0005667,transcription regulator complex	GO:0005524,ATP binding;GO:0004677,DNA-dependent protein kinase activity;GO:0003690,double-stranded DNA binding;GO:0019899,enzyme binding;GO:0019904,protein domain specific binding;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0003723,RNA binding;GO:0008134,transcription factor binding;GO:0034511,U3 snoRNA binding;GO:0016301,kinase activity	GO:0002218,activation of innate immune response;GO:0002326,B cell lineage commitment;GO:0007420,brain development;GO:0006464,cellular protein modification process;GO:0006974,cellular response to DNA damage stimulus;GO:0032869,cellular response to insulin stimulus;GO:0006302,double-strand break repair;GO:0097681,double-strand break repair via alternative nonhomologous end joining;GO:0006303,double-strand break repair via nonhomologous end joining;GO:0035234,ectopic germ cell programmed cell death;GO:0007507,heart development;GO:0033152,immunoglobulin V(D)J recombination;GO:0045087,innate immune response;GO:0008630,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0000460,maturation of 5.8S rRNA;GO:0043066,negative regulation of apoptotic process;GO:2000773,negative regulation of cellular senescence;GO:0002638,negative regulation of immunoglobulin production;GO:0001933,negative regulation of protein phosphorylation;GO:2001229,negative regulation of response to gamma radiation;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:0043065,positive regulation of apoptotic process;GO:0048639,positive regulation of developmental growth;GO:2001034,positive regulation of double-strand break repair via nonhomologous end joining;GO:0045648,positive regulation of erythrocyte differentiation;GO:0048146,positive regulation of fibroblast proliferation;GO:0045621,positive regulation of lymphocyte differentiation;GO:1905221,positive regulation of platelet formation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045727,positive regulation of translation;GO:0032481,positive regulation of type I interferon production;GO:0002328,pro-B cell differentiation;GO:0031648,protein destabilization;GO:0006468,protein phosphorylation;GO:0016567,protein ubiquitination;GO:0042752,regulation of circadian rhythm;GO:0050678,regulation of epithelial cell proliferation;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:0048660,regulation of smooth muscle cell proliferation;GO:0014823,response to activity;GO:0010332,response to gamma radiation;GO:0048511,rhythmic process;GO:0072431,signal transduction involved in mitotic G1 DNA damage checkpoint;GO:0034462,small-subunit processome assembly;GO:0001756,somitogenesis;GO:0048536,spleen development;GO:0033077,T cell differentiation in thymus;GO:0002360,T cell lineage commitment;GO:0033153,T cell receptor V(D)J recombination;GO:0016233,telomere capping;GO:0000723,telomere maintenance;GO:0048538,thymus development	hsa:5591,path:hsa03450,Non-homologous end-joining;hsa:5591,path:hsa04110,Cell cycle
ROCK1_HUMAN	Q13464	ROCK1	Rho-associated protein kinase 1	0.237388966	0.10833885	0.215025489	0.212681606	0.172863908	0.2138535475	0.172863908	0.2138535475	0.808328456650924	0.491681	0	1.23712086562338	0.491781	0	GO:0032059,bleb;GO:0005814,centriole;GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0000139,Golgi membrane;GO:0030027,lamellipodium;GO:0005886,plasma membrane;GO:0001726,ruffle;GO:0034774,secretory granule lumen	GO:0019828,aspartic-type endopeptidase inhibitor activity;GO:0005524,ATP binding;GO:0046872,metal ion binding;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0072518,Rho-dependent protein serine/threonine kinase activity;GO:0031267,small GTPase binding;GO:0048156,tau protein binding;GO:0050321,tau-protein kinase activity	GO:0030036,actin cytoskeleton organization;GO:0031032,actomyosin structure organization;GO:0003180,aortic valve morphogenesis;GO:0006915,apoptotic process;GO:0097746,blood vessel diameter maintenance;GO:0030866,cortical actin cytoskeleton organization;GO:0048598,embryonic morphogenesis;GO:0048013,ephrin receptor signaling pathway;GO:0001837,epithelial to mesenchymal transition;GO:0007186,G protein-coupled receptor signaling pathway;GO:0090521,glomerular visceral epithelial cell migration;GO:0007249,I-kappaB kinase/NF-kappaB signaling;GO:0007159,leukocyte cell-cell adhesion;GO:0050900,leukocyte migration;GO:0050901,leukocyte tethering or rolling;GO:0022614,membrane to membrane docking;GO:0000281,mitotic cytokinesis;GO:0061157,mRNA destabilization;GO:0051451,myoblast migration;GO:1902992,negative regulation of amyloid precursor protein catabolic process;GO:1902430,negative regulation of amyloid-beta formation;GO:0016525,negative regulation of angiogenesis;GO:1903347,negative regulation of bicellular tight junction assembly;GO:0070168,negative regulation of biomineral tissue development;GO:0051045,negative regulation of membrane protein ectodomain proteolysis;GO:0035509,negative regulation of myosin-light-chain-phosphatase activity;GO:0042326,negative regulation of phosphorylation;GO:0032091,negative regulation of protein binding;GO:0140058,neuron projection arborization;GO:0031175,neuron projection development;GO:0043312,neutrophil degranulation;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:1900223,positive regulation of amyloid-beta clearance;GO:0010508,positive regulation of autophagy;GO:0010613,positive regulation of cardiac muscle hypertrophy;GO:1905205,positive regulation of connective tissue replacement;GO:0051894,positive regulation of focal adhesion assembly;GO:0010628,positive regulation of gene expression;GO:0043410,positive regulation of MAPK cascade;GO:0072659,protein localization to plasma membrane;GO:0006468,protein phosphorylation;GO:0032956,regulation of actin cytoskeleton organization;GO:1902003,regulation of amyloid-beta formation;GO:0110061,regulation of angiotensin-activated signaling pathway;GO:0010506,regulation of autophagy;GO:0030155,regulation of cell adhesion;GO:1901888,regulation of cell junction assembly;GO:0030334,regulation of cell migration;GO:2000145,regulation of cell motility;GO:2000114,regulation of establishment of cell polarity;GO:1903140,regulation of establishment of endothelial barrier;GO:0051893,regulation of focal adhesion assembly;GO:0045616,regulation of keratinocyte differentiation;GO:0070507,regulation of microtubule cytoskeleton organization;GO:0045664,regulation of neuron differentiation;GO:0051492,regulation of stress fiber assembly;GO:1900242,regulation of synaptic vesicle endocytosis;GO:1990776,response to angiotensin;GO:0071559,response to transforming growth factor beta;GO:0007266,Rho protein signal transduction;GO:0007165,signal transduction;GO:0006939,smooth muscle contraction;GO:0048010,vascular endothelial growth factor receptor signaling pathway	hsa:6093,path:hsa04350,TGF-beta signaling pathway;hsa:6093,path:hsa04071,Sphingolipid signaling pathway;hsa:6093,path:hsa04024,cAMP signaling pathway;hsa:6093,path:hsa04022,cGMP-PKG signaling pathway;hsa:6093,path:hsa04510,Focal adhesion;hsa:6093,path:hsa04530,Tight junction;hsa:6093,path:hsa04810,Regulation of actin cytoskeleton;hsa:6093,path:hsa04611,Platelet activation;hsa:6093,path:hsa04670,Leukocyte transendothelial migration;hsa:6093,path:hsa04062,Chemokine signaling pathway;hsa:6093,path:hsa04921,Oxytocin signaling pathway;hsa:6093,path:hsa04270,Vascular smooth muscle contraction;hsa:6093,path:hsa04360,Axon guidance;hsa:6093,path:hsa05200,Pathways in cancer;hsa:6093,path:hsa05206,MicroRNAs in cancer;hsa:6093,path:hsa05205,Proteoglycans in cancer;hsa:6093,path:hsa05130,Pathogenic Escherichia coli infection;hsa:6093,path:hsa05131,Shigellosis;hsa:6093,path:hsa05135,Yersinia infection;hsa:6093,path:hsa05163,Human cytomegalovirus infection
SPTB2_HUMAN	Q01082	SPTBN1	Spectrin beta chain, non-erythrocytic 1	15.92972847	22.87785848	36.76828185	121.9531289	19.403793475	79.360705375	19.403793475	79.360705375	0.244501272806385	0.032286	-1	4.08995825879352	0.032456	1	GO:0030673,axolemma;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0031430,M band;GO:0005730,nucleolus;GO:0008091,spectrin;GO:0014731,spectrin-associated cytoskeleton;GO:0032437,cuticular plate;GO:0098978,glutamatergic synapse;GO:0005634,nucleus;GO:0014069,postsynaptic density	GO:0003779,actin binding;GO:0030506,ankyrin binding;GO:0045296,cadherin binding;GO:0005516,calmodulin binding;GO:0051020,GTPase binding;GO:0005543,phospholipid binding;GO:0003723,RNA binding;GO:0005200,structural constituent of cytoskeleton;GO:0044877,protein-containing complex binding	GO:0051693,actin filament capping;GO:0007411,axon guidance;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0043001,Golgi to plasma membrane protein transport;GO:0000165,MAPK cascade;GO:0071709,membrane assembly;GO:0000281,mitotic cytokinesis;GO:0007009,plasma membrane organization;GO:0032743,positive regulation of interleukin-2 production;GO:1903078,positive regulation of protein localization to plasma membrane;GO:0072659,protein localization to plasma membrane;GO:1903076,regulation of protein localization to plasma membrane;GO:0007182,common-partner SMAD protein phosphorylation;GO:0060390,regulation of SMAD protein signal transduction	
RAB3D_HUMAN	O95716	RAB3D	Ras-related protein Rab-3D	0.195136482	0.48927253	0.040011629	2.55E-05	0.342204506	0.0200185645	0.342204506	0.0200185645	17.0943578896479	0.005226	1	0.0584988337354038	0.005138	-1	GO:0035577,azurophil granule membrane;GO:0005881,cytoplasmic microtubule;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005886,plasma membrane;GO:0099503,secretory vesicle;GO:0008021,synaptic vesicle;GO:0042588,zymogen granule	GO:0005525,GTP binding;GO:0030742,GTP-dependent protein binding;GO:0003924,GTPase activity;GO:0031489,myosin V binding	GO:0045453,bone resorption;GO:0043312,neutrophil degranulation;GO:0018125,peptidyl-cysteine methylation;GO:1903307,positive regulation of regulated secretory pathway;GO:0072659,protein localization to plasma membrane;GO:0009306,protein secretion;GO:0017157,regulation of exocytosis;GO:0006904,vesicle docking involved in exocytosis	hsa:9545,path:hsa04972,Pancreatic secretion
ARAF_HUMAN	P10398	ARAF	Serine/threonine-protein kinase A-Raf	0.293400206	0.193540833	0.404672579	1.175034445	0.2434705195	0.789853512	0.2434705195	0.789853512	0.308247688718259	0.067568	0	3.24414435728018	0.067822	0	GO:0005829,cytosol;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0004709,MAP kinase kinase kinase activity;GO:0046872,metal ion binding;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity	GO:0006464,cellular protein modification process;GO:0000165,MAPK cascade;GO:0043066,negative regulation of apoptotic process;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0032434,regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032006,regulation of TOR signaling	hsa:369,path:hsa04010,MAPK signaling pathway;hsa:369,path:hsa04012,ErbB signaling pathway;hsa:369,path:hsa04068,FoxO signaling pathway;hsa:369,path:hsa04810,Regulation of actin cytoskeleton;hsa:369,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:369,path:hsa04910,Insulin signaling pathway;hsa:369,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:369,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:369,path:hsa04270,Vascular smooth muscle contraction;hsa:369,path:hsa04726,Serotonergic synapse;hsa:369,path:hsa04720,Long-term potentiation;hsa:369,path:hsa04730,Long-term depression;hsa:369,path:hsa05200,Pathways in cancer;hsa:369,path:hsa05205,Proteoglycans in cancer;hsa:369,path:hsa05210,Colorectal cancer;hsa:369,path:hsa05212,Pancreatic cancer;hsa:369,path:hsa05225,Hepatocellular carcinoma;hsa:369,path:hsa05226,Gastric cancer;hsa:369,path:hsa05214,Glioma;hsa:369,path:hsa05221,Acute myeloid leukemia;hsa:369,path:hsa05220,Chronic myeloid leukemia;hsa:369,path:hsa05218,Melanoma;hsa:369,path:hsa05211,Renal cell carcinoma;hsa:369,path:hsa05219,Bladder cancer;hsa:369,path:hsa05215,Prostate cancer;hsa:369,path:hsa05213,Endometrial cancer;hsa:369,path:hsa05224,Breast cancer;hsa:369,path:hsa05223,Non-small cell lung cancer;hsa:369,path:hsa05034,Alcoholism;hsa:369,path:hsa05161,Hepatitis B;hsa:369,path:hsa05160,Hepatitis C;hsa:369,path:hsa01521,EGFR tyrosine kinase inhibitor resistance;hsa:369,path:hsa01522,Endocrine resistance
PSB8_HUMAN	P28062	PSMB8	Proteasome subunit beta type-8	3.919226501	13.48887167	0.774119668	2.55E-05	8.7040490855	0.387072584	8.7040490855	0.387072584	22.4868653717412	0.002622	1	0.0444704045436532	0.002571	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000502,proteasome complex;GO:0005839,proteasome core complex;GO:0019774,proteasome core complex, beta-subunit complex;GO:1990111,spermatoproteasome complex	GO:0004175,endopeptidase activity;GO:0004298,threonine-type endopeptidase activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0045444,fat cell differentiation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:0052548,regulation of endopeptidase activity;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0051603,proteolysis involved in cellular protein catabolic process	hsa:5696,path:hsa03050,Proteasome
CSTF1_HUMAN	Q05048	CSTF1	Cleavage stimulation factor subunit 1	0.07504574	0.044541502	0.272286601	0.035019774	0.059793621	0.1536531875	0.059793621	0.1536531875	0.389146635828821	0.127561	0	2.56972541435482	0.127881	0	GO:0005848,mRNA cleavage stimulating factor complex;GO:0005654,nucleoplasm	GO:0003723,RNA binding	GO:0031124,mRNA 3'-end processing;GO:0000398,mRNA splicing, via spliceosome;GO:0006369,termination of RNA polymerase II transcription	hsa:1477,path:hsa03015,mRNA surveillance pathway
ZFR_HUMAN	Q96KR1	ZFR	Zinc finger RNA-binding protein	0.193183497	0.088961476	0.205301944	0.066587943	0.1410724865	0.1359449435	0.1410724865	0.1359449435	1.03771779124687	0.421110	0	0.963653132320738	0.420887	0	GO:0005694,chromosome;GO:0005737,cytoplasm;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0003725,double-stranded RNA binding;GO:0003723,RNA binding;GO:0003727,single-stranded RNA binding;GO:0008270,zinc ion binding	GO:0007275,multicellular organism development	
MYH14_HUMAN	Q7Z406	MYH14	Myosin-14	7.972430314	11.73830334	9.035329947	17.84967206	9.855366827	13.4425010035	9.855366827	13.4425010035	0.733149792916807	0.432491	0	1.36397774324063	0.432657	0	GO:0042641,actomyosin;GO:0005903,brush border;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0030426,growth cone;GO:0016020,membrane;GO:0016460,myosin II complex;GO:0097513,myosin II filament;GO:0001725,stress fiber;GO:0016459,myosin complex	GO:0051015,actin filament binding;GO:0030898,actin-dependent ATPase activity;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0005516,calmodulin binding;GO:0000146,microfilament motor activity;GO:0003779,actin binding;GO:0003774,motor activity	GO:0030048,actin filament-based movement;GO:0031032,actomyosin structure organization;GO:0070584,mitochondrion morphogenesis;GO:0019228,neuronal action potential;GO:0008360,regulation of cell shape;GO:0007605,sensory perception of sound;GO:0003009,skeletal muscle contraction;GO:0007519,skeletal muscle tissue development;GO:0071625,vocalization behavior	hsa:79784,path:hsa04530,Tight junction;hsa:79784,path:hsa04810,Regulation of actin cytoskeleton;hsa:79784,path:hsa05130,Pathogenic Escherichia coli infection;hsa:79784,path:hsa05132,Salmonella infection
CDC37_HUMAN	Q16543	CDC37	Hsp90 co-chaperone Cdc37	1.527930555	2.359982753	1.99954536	2.878685664	1.943956654	2.439115512	1.943956654	2.439115512	0.796992452565732	0.483075	0	1.25471702621616	0.483185	0	GO:0101031,chaperone complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:1990565,HSP90-CDC37 chaperone complex	GO:0051087,chaperone binding;GO:0031072,heat shock protein binding;GO:0051879,Hsp90 protein binding;GO:0019900,kinase binding;GO:0019901,protein kinase binding;GO:0019887,protein kinase regulator activity;GO:0097110,scaffold protein binding;GO:0051082,unfolded protein binding	GO:0038128,ERBB2 signaling pathway;GO:0098779,positive regulation of mitophagy in response to mitochondrial depolarization;GO:0010608,posttranscriptional regulation of gene expression;GO:0006457,protein folding;GO:0050821,protein stabilization;GO:0006605,protein targeting;GO:0000079,regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0060334,regulation of interferon-gamma-mediated signaling pathway;GO:0060544,regulation of necroptotic process;GO:0060338,regulation of type I interferon-mediated signaling pathway	hsa:11140,path:hsa04151,PI3K-Akt signaling pathway
BABA2_HUMAN	Q9NXR7	BABAM2	BRISC and BRCA1-A complex member 2	0.051097835	0.057389829	0.14577939	0.047366353	0.054243832	0.0965728715	0.054243832	0.0965728715	0.561688092706242	0.281916	0	1.78034751490271	0.282217	0	GO:0070531,BRCA1-A complex;GO:0070552,BRISC complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0000152,nuclear ubiquitin ligase complex;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0000268,peroxisome targeting sequence binding;GO:0031593,polyubiquitin modification-dependent protein binding;GO:0005164,tumor necrosis factor receptor binding	GO:0006915,apoptotic process;GO:0007049,cell cycle;GO:0051301,cell division;GO:0006974,cellular response to DNA damage stimulus;GO:0006325,chromatin organization;GO:0006302,double-strand break repair;GO:0006303,double-strand break repair via nonhomologous end joining;GO:0043066,negative regulation of apoptotic process;GO:0045739,positive regulation of DNA repair;GO:0016579,protein deubiquitination;GO:0070536,protein K63-linked deubiquitination;GO:0010212,response to ionizing radiation;GO:0007165,signal transduction;GO:0072425,signal transduction involved in G2 DNA damage checkpoint	hsa:9577,path:hsa03440,Homologous recombination
TXNL1_HUMAN	O43396	TXNL1	Thioredoxin-like protein 1	1.474841427	0.331975988	1.263357383	1.306214879	0.9034087075	1.284786131	0.9034087075	1.284786131	0.703158825972725	0.407545	0	1.42215380517572	0.407737	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus;GO:0000502,proteasome complex	GO:0015036,disulfide oxidoreductase activity		
THY1_HUMAN	P04216	THY1	Thy-1 membrane glycoprotein	1.467448306	2.769040125	1.174924001	1.156462355	2.1182442155	1.165693178	2.1182442155	1.165693178	1.81715416670303	0.251025	0	0.550311040374938	0.250508	0	GO:0031362,anchored component of external side of plasma membrane;GO:0016324,apical plasma membrane;GO:0030673,axolemma;GO:0009986,cell surface;GO:0030425,dendrite;GO:0032590,dendrite membrane;GO:0005783,endoplasmic reticulum;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005925,focal adhesion;GO:0030426,growth cone;GO:0005887,integral component of plasma membrane;GO:0045121,membrane raft;GO:0032809,neuronal cell body membrane;GO:0005886,plasma membrane;GO:0031225,anchored component of membrane;GO:0005829,cytosol	GO:0034235,GPI anchor binding;GO:0005096,GTPase activator activity;GO:0005178,integrin binding;GO:0019901,protein kinase binding	GO:0001525,angiogenesis;GO:0098609,cell-cell adhesion;GO:0007267,cell-cell signaling;GO:0007010,cytoskeleton organization;GO:0048041,focal adhesion assembly;GO:0007229,integrin-mediated signaling pathway;GO:0050771,negative regulation of axonogenesis;GO:0030336,negative regulation of cell migration;GO:0070571,negative regulation of neuron projection regeneration;GO:0006469,negative regulation of protein kinase activity;GO:0061099,negative regulation of protein tyrosine kinase activity;GO:0050860,negative regulation of T cell receptor signaling pathway;GO:0002693,positive regulation of cellular extravasation;GO:0051894,positive regulation of focal adhesion assembly;GO:0043547,positive regulation of GTPase activity;GO:0034116,positive regulation of heterotypic cell-cell adhesion;GO:0051281,positive regulation of release of sequestered calcium ion into cytosol;GO:0050870,positive regulation of T cell activation;GO:0043113,receptor clustering;GO:0001952,regulation of cell-matrix adhesion;GO:2000298,regulation of Rho-dependent protein serine/threonine kinase activity;GO:0046549,retinal cone cell development;GO:0050852,T cell receptor signaling pathway;GO:0007155,cell adhesion;GO:0030334,regulation of cell migration;GO:0046777,protein autophosphorylation	hsa:7070,path:hsa04670,Leukocyte transendothelial migration
HINT2_HUMAN	Q9BX68	HINT2	Histidine triad nucleotide-binding protein 2, mitochondrial	2.174872446	2.762805403	0.265011189	0.118953168	2.4688389245	0.1919821785	2.4688389245	0.1919821785	12.8597297092344	0.010154	1	0.0777621320673567	0.010012	-1	GO:0005737,cytoplasm;GO:0005739,mitochondrion	GO:0016787,hydrolase activity;GO:0000166,nucleotide binding	GO:0006915,apoptotic process;GO:0016042,lipid catabolic process;GO:2000757,negative regulation of peptidyl-lysine acetylation;GO:0006694,steroid biosynthetic process	
INP5K_HUMAN	Q9BT40	INPP5K	Inositol polyphosphate 5-phosphatase K	0.061001591	0.137598242	0.148129197	0.173964853	0.0992999165	0.161047025	0.0992999165	0.161047025	0.61658957375959	0.331912	0	1.62182437484728	0.332175	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0016020,membrane;GO:0043005,neuron projection;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0001726,ruffle;GO:0032587,ruffle membrane;GO:0005802,trans-Golgi network	GO:0016312,inositol bisphosphate phosphatase activity;GO:0046030,inositol trisphosphate phosphatase activity;GO:0052659,inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity;GO:0052658,inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0004445,inositol-polyphosphate 5-phosphatase activity;GO:0042577,lipid phosphatase activity;GO:0034595,phosphatidylinositol phosphate 5-phosphatase activity;GO:0034594,phosphatidylinositol trisphosphate phosphatase activity;GO:0034485,phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity;GO:0004439,phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0005000,vasopressin receptor activity	GO:0030036,actin cytoskeleton organization;GO:0071320,cellular response to cAMP;GO:0071364,cellular response to epidermal growth factor stimulus;GO:0032870,cellular response to hormone stimulus;GO:0032869,cellular response to insulin stimulus;GO:0071356,cellular response to tumor necrosis factor;GO:0016311,dephosphorylation;GO:0007186,G protein-coupled receptor signaling pathway;GO:0042593,glucose homeostasis;GO:0001701,in utero embryonic development;GO:0046855,inositol phosphate dephosphorylation;GO:0043922,negative regulation by host of viral transcription;GO:0051926,negative regulation of calcium ion transport;GO:0035305,negative regulation of dephosphorylation;GO:0010829,negative regulation of glucose transmembrane transport;GO:2000466,negative regulation of glycogen (starch) synthase activity;GO:0045719,negative regulation of glycogen biosynthetic process;GO:0046627,negative regulation of insulin receptor signaling pathway;GO:0043407,negative regulation of MAP kinase activity;GO:0033137,negative regulation of peptidyl-serine phosphorylation;GO:0010801,negative regulation of peptidyl-threonine phosphorylation;GO:0006469,negative regulation of protein kinase activity;GO:0051898,negative regulation of protein kinase B signaling;GO:0001933,negative regulation of protein phosphorylation;GO:0090315,negative regulation of protein targeting to membrane;GO:0045869,negative regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0051497,negative regulation of stress fiber assembly;GO:0045892,negative regulation of transcription, DNA-templated;GO:0006661,phosphatidylinositol biosynthetic process;GO:0046856,phosphatidylinositol dephosphorylation;GO:2001153,positive regulation of renal water transport;GO:0045893,positive regulation of transcription, DNA-templated;GO:0035810,positive regulation of urine volume;GO:0072659,protein localization to plasma membrane;GO:0005979,regulation of glycogen biosynthetic process;GO:0097178,ruffle assembly	hsa:51763,path:hsa00562,Inositol phosphate metabolism;hsa:51763,path:hsa04070,Phosphatidylinositol signaling system;hsa:51763,path:hsa04910,Insulin signaling pathway
CND1_HUMAN	Q15021	NCAPD2	Condensin complex subunit 1	0.015291873	0.030751698	0.042285163	0.086652896	0.0230217855	0.0644690295	0.0230217855	0.0644690295	0.357098372327755	0.102160	0	2.8003488043966	0.102461	0	GO:0000793,condensed chromosome;GO:0000779,condensed chromosome, centromeric region;GO:0000796,condensin complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003682,chromatin binding;GO:0042393,histone binding	GO:0051301,cell division;GO:0010032,meiotic chromosome condensation;GO:0007076,mitotic chromosome condensation	
NDE1_HUMAN	Q9NXR1	NDE1	Nuclear distribution protein nudE homolog 1	0.00701091	2.55E-05	0.033867792	0.011219732	0.003518205	0.022543762	0.003518205	0.022543762	0.156061131234441	0.005633	-1	6.40774542700042	0.005684	1	GO:0005813,centrosome;GO:0032154,cleavage furrow;GO:0000777,condensed chromosome kinetochore;GO:0005829,cytosol;GO:0005871,kinesin complex;GO:0000776,kinetochore;GO:0016020,membrane;GO:0005874,microtubule;GO:0031616,spindle pole centrosome;GO:0005737,cytoplasm;GO:0005819,spindle;GO:0045202,synapse	GO:0042802,identical protein binding;GO:0008017,microtubule binding;GO:0019904,protein domain specific binding	GO:0030154,cell differentiation;GO:0051301,cell division;GO:0016477,cell migration;GO:0051298,centrosome duplication;GO:0051642,centrosome localization;GO:0021987,cerebral cortex development;GO:0007059,chromosome segregation;GO:0097711,ciliary basal body-plasma membrane docking;GO:0051303,establishment of chromosome localization;GO:0000132,establishment of mitotic spindle orientation;GO:0000086,G2/M transition of mitotic cell cycle;GO:0007020,microtubule nucleation;GO:0007100,mitotic centrosome separation;GO:0007052,mitotic spindle organization;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:2000574,regulation of microtubule motor activity;GO:0047496,vesicle transport along microtubule;GO:0007405,neuroblast proliferation;GO:0001764,neuron migration	
SRS11_HUMAN	Q05519	SRSF11	Serine/arginine-rich splicing factor 11	0.181672884	0.111899635	0.356683484	0.044208984	0.1467862595	0.200446234	0.1467862595	0.200446234	0.732297417471061	0.431792	0	1.36556537841337	0.431959	0	GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0042802,identical protein binding;GO:0003723,RNA binding	GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0006405,RNA export from nucleus;GO:0008380,RNA splicing	
CELF2_HUMAN	O95319	CELF2	CUGBP Elav-like family member 2	0.120295293	0.108478662	0.39105436	0.822926324	0.1143869775	0.606990342	0.1143869775	0.606990342	0.188449419348422	0.012347	-1	5.3064636837703	0.012437	1	GO:0005737,cytoplasm;GO:0090543,Flemming body;GO:0043231,intracellular membrane-bounded organelle;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0005576,extracellular region	GO:0003730,mRNA 3'-UTR binding;GO:0003729,mRNA binding;GO:0036002,pre-mRNA binding;GO:0003723,RNA binding	GO:0006376,mRNA splice site selection;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0008016,regulation of heart contraction;GO:0006396,RNA processing	
IPO9_HUMAN	Q96P70	IPO9	Importin-9	1.46695562	0.511644817	1.542681933	0.785295133	0.9893002185	1.163988533	0.9893002185	1.163988533	0.849922649968237	0.487718	0	1.17657765684603	0.487641	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005635,nuclear envelope	GO:0042393,histone binding;GO:0061608,nuclear import signal receptor activity;GO:0031267,small GTPase binding	GO:0006606,protein import into nucleus	
SRBS1_HUMAN	Q9BX66	SORBS1	Sorbin and SH3 domain-containing protein 1	0.143705867	0.212236493	0.485567558	0.344216028	0.17797118	0.414891793	0.17797118	0.414891793	0.428958063289529	0.161296	0	2.33123021940968	0.161630	0	GO:0005912,adherens junction;GO:0030055,cell-substrate junction;GO:0005813,centrosome;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0045121,membrane raft;GO:0016363,nuclear matrix;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0001725,stress fiber;GO:0005915,zonula adherens	GO:0003779,actin binding;GO:0008092,cytoskeletal protein binding;GO:0005158,insulin receptor binding;GO:0030159,signaling receptor complex adaptor activity	GO:0007160,cell-matrix adhesion;GO:0032869,cellular response to insulin stimulus;GO:0048041,focal adhesion assembly;GO:0008286,insulin receptor signaling pathway;GO:0006936,muscle contraction;GO:0046326,positive regulation of glucose import;GO:0045725,positive regulation of glycogen biosynthetic process;GO:0046628,positive regulation of insulin receptor signaling pathway;GO:0046889,positive regulation of lipid biosynthetic process;GO:1903078,positive regulation of protein localization to plasma membrane;GO:0043149,stress fiber assembly	hsa:10580,path:hsa04520,Adherens junction;hsa:10580,path:hsa04910,Insulin signaling pathway;hsa:10580,path:hsa03320,PPAR signaling pathway
PP6R1_HUMAN	Q9UPN7	PPP6R1	Serine/threonine-protein phosphatase 6 regulatory subunit 1	3.409233365	0.484985543	1.842889523	34.85677538	1.947109454	18.3498324515	1.947109454	18.3498324515	0.106110475893791	0.000892	-1	9.4241401857525	0.000904	1	GO:0005829,cytosol;GO:0005634,nucleus	GO:0019903,protein phosphatase binding;GO:0019888,protein phosphatase regulator activity;GO:0031267,small GTPase binding	GO:0048208,COPII vesicle coating;GO:0043666,regulation of phosphoprotein phosphatase activity	
RL23A_HUMAN	P62750	RPL23A	60S ribosomal protein L23a	6.737911188	11.93593705	1.764520361	1.068941059	9.336924119	1.41673071	9.336924119	1.41673071	6.59047203049618	0.039444	1	0.151734199822514	0.039100	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0070062,extracellular exosome;GO:0005730,nucleolus;GO:0005634,nucleus;GO:0005840,ribosome	GO:0045296,cadherin binding;GO:0003723,RNA binding;GO:0019843,rRNA binding;GO:0003735,structural constituent of ribosome;GO:1904841,TORC2 complex binding	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000027,ribosomal large subunit assembly;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6147,path:hsa03010,Ribosome
PININ_HUMAN	Q9H307	PNN	Pinin	0.818331056	0.421847255	0.523144922	1.096984234	0.6200891555	0.810064578	0.6200891555	0.810064578	0.765481138591398	0.458550	0	1.3063679163149	0.458688	0	GO:0071013,catalytic step 2 spliceosome;GO:0005911,cell-cell junction;GO:0030057,desmosome;GO:0005882,intermediate filament;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005886,plasma membrane	GO:0003677,DNA binding;GO:0003723,RNA binding;GO:0005198,structural molecule activity	GO:0007155,cell adhesion;GO:0000398,mRNA splicing, via spliceosome	hsa:5411,path:hsa03013,RNA transport;hsa:5411,path:hsa03015,mRNA surveillance pathway
NB5R3_HUMAN	P00387	CYB5R3	NADH-cytochrome b5 reductase 3	7.949957718	15.72729954	9.424777035	12.70324483	11.838628629	11.0640109325	11.838628629	11.0640109325	1.07001237627347	0.411034	0	0.934568629460807	0.410790	0	GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005576,extracellular region;GO:0005833,hemoglobin complex;GO:0005811,lipid droplet;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:1903958,nitric-oxide synthase complex	GO:0043531,ADP binding;GO:0016208,AMP binding;GO:0004128,cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0071949,FAD binding;GO:0051287,NAD binding;GO:0016491,oxidoreductase activity	GO:0008015,blood circulation;GO:0006695,cholesterol biosynthetic process;GO:0019852,L-ascorbic acid metabolic process;GO:0043312,neutrophil degranulation;GO:0006809,nitric oxide biosynthetic process;GO:0006805,xenobiotic metabolic process	hsa:1727,path:hsa00520,Amino sugar and nucleotide sugar metabolism
CP51A_HUMAN	Q16850	CYP51A1	Lanosterol 14-alpha demethylase	0.119821055	0.174369639	0.272412935	0.230712804	0.147095347	0.2515628695	0.147095347	0.2515628695	0.584725986360241	0.303022	0	1.71020276732479	0.303308	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0020037,heme binding;GO:0005506,iron ion binding;GO:0004497,monooxygenase activity;GO:0016491,oxidoreductase activity;GO:0008398,sterol 14-demethylase activity;GO:0016705,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0006695,cholesterol biosynthetic process;GO:1900222,negative regulation of amyloid-beta clearance;GO:0042177,negative regulation of protein catabolic process;GO:0050709,negative regulation of protein secretion;GO:0007399,nervous system development;GO:0019216,regulation of lipid metabolic process;GO:0006694,steroid biosynthetic process;GO:0016125,sterol metabolic process;GO:0033488,cholesterol biosynthetic process via 24,25-dihydrolanosterol	hsa:1595,path:hsa00100,Steroid biosynthesis
HNRPM_HUMAN	P52272	HNRNPM	Heterogeneous nuclear ribonucleoprotein M	18.10627871	20.11237136	17.5114093	14.65120281	19.109325035	16.081306055	19.109325035	16.081306055	1.1882943443551	0.377042	0	0.841542337342947	0.376729	0	GO:0071013,catalytic step 2 spliceosome;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0016363,nuclear matrix;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0042382,paraspeckles;GO:0071014,post-mRNA release spliceosomal complex;GO:1990904,ribonucleoprotein complex;GO:0005681,spliceosomal complex	GO:0003729,mRNA binding;GO:0019904,protein domain specific binding;GO:0003723,RNA binding	GO:0000380,alternative mRNA splicing, via spliceosome;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0000398,mRNA splicing, via spliceosome;GO:2000815,regulation of mRNA stability involved in response to oxidative stress;GO:0016070,RNA metabolic process	hsa:4670,path:hsa03040,Spliceosome
PCH2_HUMAN	Q15645	TRIP13	Pachytene checkpoint protein 2 homolog	0.166025493	0.010461405	0.05601933	0.130943703	0.088243449	0.0934815165	0.088243449	0.0934815165	0.943966810807995	0.452540	0	1.05935927889673	0.452385	0	GO:0005694,chromosome;GO:0001673,male germ cell nucleus;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0042802,identical protein binding;GO:0003712,transcription coregulator activity	GO:0006302,double-strand break repair;GO:0007144,female meiosis I;GO:0007141,male meiosis I;GO:0051598,meiotic recombination checkpoint;GO:0007094,mitotic spindle assembly checkpoint;GO:0001556,oocyte maturation;GO:0048477,oogenesis;GO:0007131,reciprocal meiotic recombination;GO:0007286,spermatid development;GO:0007283,spermatogenesis;GO:0007130,synaptonemal complex assembly;GO:0006366,transcription by RNA polymerase II	
ITB4_HUMAN	P16144	ITGB4	Integrin beta-4	0.14260919	0.406611542	0.394318734	1.001995154	0.274610366	0.698156944	0.274610366	0.698156944	0.393336152221957	0.131009	0	2.54235466114924	0.131332	0	GO:0009925,basal plasma membrane;GO:0005604,basement membrane;GO:0030054,cell junction;GO:0031252,cell leading edge;GO:0009986,cell surface;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0030056,hemidesmosome;GO:0008305,integrin complex;GO:0031965,nuclear membrane;GO:0005730,nucleolus;GO:0005886,plasma membrane;GO:0043235,receptor complex	GO:0001664,G protein-coupled receptor binding;GO:0005178,integrin binding	GO:0006914,autophagy;GO:0007155,cell adhesion;GO:0033627,cell adhesion mediated by integrin;GO:0016477,cell migration;GO:0048870,cell motility;GO:0007160,cell-matrix adhesion;GO:0030199,collagen fibril organization;GO:0030198,extracellular matrix organization;GO:0046847,filopodium assembly;GO:0031581,hemidesmosome assembly;GO:0007229,integrin-mediated signaling pathway;GO:0048333,mesodermal cell differentiation;GO:0035878,nail development;GO:0032290,peripheral nervous system myelin formation;GO:0009611,response to wounding;GO:0043589,skin morphogenesis;GO:0061450,trophoblast cell migration	hsa:3691,path:hsa04151,PI3K-Akt signaling pathway;hsa:3691,path:hsa04512,ECM-receptor interaction;hsa:3691,path:hsa04510,Focal adhesion;hsa:3691,path:hsa04810,Regulation of actin cytoskeleton;hsa:3691,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:3691,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:3691,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:3691,path:hsa05165,Human papillomavirus infection
GMPPA_HUMAN	Q96IJ6	GMPPA	Mannose-1-phosphate guanyltransferase alpha	1.578468589	0.565063054	1.604298511	0.867484393	1.0717658215	1.235891452	1.0717658215	1.235891452	0.867200610349395	0.480956	0	1.15313571976973	0.480864	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome	GO:0016779,nucleotidyltransferase activity;GO:0016740,transferase activity	GO:0009058,biosynthetic process	hsa:29926,path:hsa00051,Fructose and mannose metabolism;hsa:29926,path:hsa00520,Amino sugar and nucleotide sugar metabolism
OGA_HUMAN	O60502	OGA	Protein O-GlcNAcase	0.031620596	2.55E-05	0.07200816	2.55E-05	0.015823048	0.03601683	0.015823048	0.03601683	0.439323727268613	0.170382	0	2.27622579417063	0.170717	0	GO:0005829,cytosol;GO:0016020,membrane;GO:0005634,nucleus	GO:0102167,[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity;GO:0102571,[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity;GO:0102166,[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity;GO:0016231,beta-N-acetylglucosaminidase activity;GO:0004415,hyalurononglucosaminidase activity;GO:0016798,hydrolase activity, acting on glycosyl bonds	GO:0006516,glycoprotein catabolic process;GO:0009100,glycoprotein metabolic process;GO:0006044,N-acetylglucosamine metabolic process;GO:0006517,protein deglycosylation;GO:0006493,protein O-linked glycosylation;GO:0016032,viral process;GO:0008152,metabolic process	hsa:10724,path:hsa04931,Insulin resistance
KPRA_HUMAN	Q14558	PRPSAP1	Phosphoribosyl pyrophosphate synthase-associated protein 1	0.105521916	0.116804818	0.384415572	0.221976614	0.111163367	0.303196093	0.111163367	0.303196093	0.366638520635554	0.109527	0	2.72748209398875	0.109834	0	GO:0005737,cytoplasm;GO:0002189,ribose phosphate diphosphokinase complex	GO:0004857,enzyme inhibitor activity;GO:0042802,identical protein binding;GO:0000287,magnesium ion binding;GO:0004749,ribose phosphate diphosphokinase activity	GO:0006015,5-phosphoribose 1-diphosphate biosynthetic process;GO:0006139,nucleobase-containing compound metabolic process;GO:0006164,purine nucleotide biosynthetic process;GO:0009165,nucleotide biosynthetic process;GO:0009116,nucleoside metabolic process	
SMU1_HUMAN	Q2TAY7	SMU1	WD40 repeat-containing protein SMU1	0.514730972	0.251918688	0.654474391	0.427060216	0.38332483	0.5407673035	0.38332483	0.5407673035	0.708853563296103	0.412337	0	1.41072860711893	0.412524	0	GO:0005737,cytoplasm;GO:0016607,nuclear speck;GO:0005634,nucleus;GO:0071011,precatalytic spliceosome;GO:0071005,U2-type precatalytic spliceosome		GO:0000398,mRNA splicing, via spliceosome;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0008380,RNA splicing;GO:0016032,viral process	
CAPZB_HUMAN	P47756	CAPZB	F-actin-capping protein subunit beta	6.380234182	9.079098807	7.644156153	7.247351886	7.7296664945	7.4457540195	7.7296664945	7.4457540195	1.03813078893776	0.420979	0	0.963269763941042	0.420756	0	GO:0015629,actin cytoskeleton;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0008290,F-actin capping protein complex;GO:0030017,sarcomere;GO:0071203,WASH complex;GO:0005903,brush border;GO:0030863,cortical cytoskeleton;GO:0098686,hippocampal mossy fiber to CA3 synapse;GO:0030027,lamellipodium;GO:0016020,membrane;GO:0014069,postsynaptic density;GO:0098685,Schaffer collateral - CA1 synapse;GO:0097224,sperm connecting piece	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0045296,cadherin binding	GO:0030036,actin cytoskeleton organization;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0051016,barbed-end actin filament capping;GO:0007596,blood coagulation;GO:0000902,cell morphogenesis;GO:0007010,cytoskeleton organization;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0051490,negative regulation of filopodium assembly;GO:0022604,regulation of cell morphogenesis;GO:0010591,regulation of lamellipodium assembly;GO:0008154,actin polymerization or depolymerization;GO:0030032,lamellipodium assembly	hsa:832,path:hsa04144,Endocytosis
HV349_HUMAN	A0A0A0MS15	IGHV3-49	Immunoglobulin heavy variable 3-49	0.236495338	0.148901754	0.378572467	1.347522019	0.192698546	0.863047243	0.192698546	0.863047243	0.22327693827069	0.023462	-1	4.47874289098165	0.023601	1	GO:0009897,external side of plasma membrane;GO:0042571,immunoglobulin complex, circulating;GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane;GO:0019814,immunoglobulin complex	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006956,complement activation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
IF6_HUMAN	P56537	EIF6	Eukaryotic translation initiation factor 6	1.586203479	1.089985768	1.644971509	2.961504211	1.3380946235	2.30323786	1.3380946235	2.30323786	0.580962412410154	0.299584	0	1.72128175358445	0.299873	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005638,lamin filament;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0030687,preribosome, large subunit precursor	GO:0043023,ribosomal large subunit binding;GO:0043022,ribosome binding;GO:0003743,translation initiation factor activity	GO:1902626,assembly of large subunit precursor of preribosome;GO:0035195,gene silencing by miRNA;GO:0000460,maturation of 5.8S rRNA;GO:0000470,maturation of LSU-rRNA;GO:0042256,mature ribosome assembly;GO:0035278,miRNA mediated inhibition of translation;GO:0045727,positive regulation of translation;GO:0042304,regulation of fatty acid biosynthetic process;GO:0006110,regulation of glycolytic process;GO:0045652,regulation of megakaryocyte differentiation;GO:2000377,regulation of reactive oxygen species metabolic process;GO:0032868,response to insulin;GO:0000054,ribosomal subunit export from nucleus	hsa:3692,path:hsa03008,Ribosome biogenesis in eukaryotes
ADDA_HUMAN	P35611	ADD1	Alpha-adducin	0.849431863	1.797884036	2.008703842	7.025138459	1.3236579495	4.5169211505	1.3236579495	4.5169211505	0.293044289549637	0.058039	0	3.41245346065895	0.058275	0	GO:0005912,adherens junction;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0008290,F-actin capping protein complex;GO:0005925,focal adhesion;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0014069,postsynaptic density	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0045296,cadherin binding;GO:0005516,calmodulin binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0003723,RNA binding;GO:0030507,spectrin binding;GO:0005200,structural constituent of cytoskeleton;GO:0008134,transcription factor binding	GO:0030036,actin cytoskeleton organization;GO:0051017,actin filament bundle assembly;GO:0051016,barbed-end actin filament capping;GO:0000902,cell morphogenesis;GO:0006884,cell volume homeostasis;GO:0071277,cellular response to calcium ion;GO:0030218,erythrocyte differentiation;GO:0020027,hemoglobin metabolic process;GO:0048873,homeostasis of number of cells within a tissue;GO:0001701,in utero embryonic development;GO:0036498,IRE1-mediated unfolded protein response;GO:0035264,multicellular organism growth;GO:1903393,positive regulation of adherens junction organization;GO:1903142,positive regulation of establishment of endothelial barrier;GO:0032092,positive regulation of protein binding;GO:0055085,transmembrane transport	
MYO1D_HUMAN	O94832	MYO1D	Unconventional myosin-Id	5.439093715	5.044514158	4.815942194	9.813576658	5.2418039365	7.314759426	5.2418039365	7.314759426	0.716606470729335	0.418819	0	1.3954660484467	0.419000	0	GO:0015629,actin cytoskeleton;GO:0097440,apical dendrite;GO:0030673,axolemma;GO:0030424,axon;GO:0016323,basolateral plasma membrane;GO:0005903,brush border;GO:0005938,cell cortex;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005769,early endosome;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005902,microvillus;GO:0043209,myelin sheath;GO:0016459,myosin complex;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0043204,perikaryon;GO:0005886,plasma membrane;GO:0044853,plasma membrane raft;GO:0005790,smooth endoplasmic reticulum;GO:0031982,vesicle	GO:0051015,actin filament binding;GO:0030898,actin-dependent ATPase activity;GO:0005524,ATP binding;GO:0048306,calcium-dependent protein binding;GO:0005516,calmodulin binding;GO:0000146,microfilament motor activity;GO:0019904,protein domain specific binding;GO:0003779,actin binding;GO:0003774,motor activity	GO:0007015,actin filament organization;GO:0051641,cellular localization;GO:0061502,early endosome to recycling endosome transport;GO:0030900,forebrain development;GO:0010923,negative regulation of phosphatase activity;GO:0015031,protein transport;GO:0030050,vesicle transport along actin filament	hsa:4642,path:hsa05130,Pathogenic Escherichia coli infection
ETHE1_HUMAN	O95571	ETHE1	Persulfide dioxygenase ETHE1, mitochondrial	1.458847175	2.864051593	1.530662248	0.882127739	2.161449384	1.2063949935	2.161449384	1.2063949935	1.79165977614777	0.254833	0	0.558141681424634	0.254320	0	GO:0005737,cytoplasm;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0016788,hydrolase activity, acting on ester bonds;GO:0042802,identical protein binding;GO:0005506,iron ion binding;GO:0050313,sulfur dioxygenase activity	GO:0006749,glutathione metabolic process;GO:0070813,hydrogen sulfide metabolic process;GO:0070221,sulfide oxidation, using sulfide	hsa:23474,path:hsa00920,Sulfur metabolism
MDHC_HUMAN	P40925	MDH1	Malate dehydrogenase, cytoplasmic	10.34213257	15.63438977	19.8506256	16.55773954	12.98826117	18.20418257	12.98826117	18.20418257	0.713476758434861	0.416208	0	1.40158735120353	0.416392	0	GO:0005813,centrosome;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space	GO:0047860,diiodophenylpyruvate reductase activity;GO:0030060,L-malate dehydrogenase activity;GO:0004470,malic enzyme activity;GO:0016615,malate dehydrogenase activity;GO:0016616,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0051287,NAD binding	GO:0006094,gluconeogenesis;GO:0006108,malate metabolic process;GO:0006734,NADH metabolic process;GO:0006107,oxaloacetate metabolic process;GO:0006099,tricarboxylic acid cycle;GO:0005975,carbohydrate metabolic process;GO:0019674,NAD metabolic process	hsa:4190,path:hsa00020,Citrate cycle (TCA cycle);hsa:4190,path:hsa00620,Pyruvate metabolism;hsa:4190,path:hsa00630,Glyoxylate and dicarboxylate metabolism;hsa:4190,path:hsa00270,Cysteine and methionine metabolism;hsa:4190,path:hsa04964,Proximal tubule bicarbonate reclamation
SLFN5_HUMAN	Q08AF3	SLFN5	Schlafen family member 5	0.222893794	0.191401864	0.526089897	0.626425399	0.207147829	0.576257648	0.207147829	0.576257648	0.359470854259274	0.103975	0	2.781866702547	0.104278	0	GO:0005634,nucleus	GO:0005524,ATP binding	GO:0030154,cell differentiation	
CO8G_HUMAN	P07360	C8G	Complement component C8 gamma chain	0.733210651	1.833212356	0.400817544	0.061557981	1.2832115035	0.2311877625	1.2832115035	0.2311877625	5.55051655686144	0.053435	0	0.180163411775399	0.053031	0	GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005579,membrane attack complex	GO:0001848,complement binding;GO:0044877,protein-containing complex binding;GO:0019841,retinol binding	GO:0006956,complement activation;GO:0006957,complement activation, alternative pathway;GO:0006958,complement activation, classical pathway;GO:0019835,cytolysis;GO:0030449,regulation of complement activation	hsa:733,path:hsa04610,Complement and coagulation cascades;hsa:733,path:hsa05322,Systemic lupus erythematosus;hsa:733,path:hsa05020,Prion diseases;hsa:733,path:hsa05146,Amoebiasis
GLUCM_HUMAN	Q7Z3D6	DGLUCY	D-glutamate cyclase, mitochondrial	0.228089915	0.499400821	0.797780496	0.646546904	0.363745368	0.7221637	0.363745368	0.7221637	0.50368824686148	0.228524	0	1.9853550410022	0.228851	0	GO:0005759,mitochondrial matrix	GO:0047820,D-glutamate cyclase activity;GO:0016829,lyase activity	GO:0006536,glutamate metabolic process	hsa:80017,path:hsa00471,D-Glutamine and D-glutamate metabolism
PTN9_HUMAN	P43378	PTPN9	Tyrosine-protein phosphatase non-receptor type 9	0.128202943	0.199317638	0.187272033	0.185420552	0.1637602905	0.1863462925	0.1637602905	0.1863462925	0.878795538687736	0.476497	0	1.13792111586417	0.476394	0	GO:0005737,cytoplasm;GO:0044306,neuron projection terminus;GO:0005654,nucleoplasm	GO:0004726,non-membrane spanning protein tyrosine phosphatase activity;GO:0004725,protein tyrosine phosphatase activity	GO:0071345,cellular response to cytokine stimulus;GO:0010977,negative regulation of neuron projection development;GO:0035335,peptidyl-tyrosine dephosphorylation;GO:1903078,positive regulation of protein localization to plasma membrane;GO:0006470,protein dephosphorylation	
DJC10_HUMAN	Q8IXB1	DNAJC10	DnaJ homolog subfamily C member 10	0.068033977	0.05717658	0.106922713	0.063731885	0.0626052785	0.085327299	0.0626052785	0.085327299	0.73370749143249	0.432948	0	1.3629409699056	0.433114	0	GO:0005783,endoplasmic reticulum;GO:0034663,endoplasmic reticulum chaperone complex;GO:0005788,endoplasmic reticulum lumen;GO:0016020,membrane;GO:0016021,integral component of membrane	GO:0001671,ATPase activator activity;GO:0051117,ATPase binding;GO:0051087,chaperone binding;GO:0015036,disulfide oxidoreductase activity;GO:0030544,Hsp70 protein binding;GO:0051787,misfolded protein binding;GO:0016671,oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;GO:0015035,protein disulfide oxidoreductase activity	GO:0070059,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0001933,negative regulation of protein phosphorylation;GO:0032781,positive regulation of ATPase activity;GO:0034975,protein folding in endoplasmic reticulum;GO:0034976,response to endoplasmic reticulum stress;GO:0030433,ubiquitin-dependent ERAD pathway	hsa:54431,path:hsa04141,Protein processing in endoplasmic reticulum
COPB2_HUMAN	P35606	COPB2	Coatomer subunit beta'	11.03993974	10.84438431	16.46658953	9.746129489	10.942162025	13.1063595095	10.942162025	13.1063595095	0.834874246892792	0.493723	0	1.19778517988999	0.493659	0	GO:0030126,COPI vesicle coat;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0000139,Golgi membrane;GO:0030133,transport vesicle;GO:0030117,membrane coat	GO:0005198,structural molecule activity	GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006891,intra-Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:1901998,toxin transport;GO:0016192,vesicle-mediated transport	
BASI_HUMAN	P35613	BSG	Basigin	1.967585178	1.946677103	1.886278074	1.055911775	1.9571311405	1.4710949245	1.9571311405	1.4710949245	1.33039079117562	0.341467	0	0.751658840870607	0.341086	0	GO:0002080,acrosomal membrane;GO:0030424,axon;GO:0016323,basolateral plasma membrane;GO:0005789,endoplasmic reticulum membrane;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0000139,Golgi membrane;GO:0005887,integral component of plasma membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0042470,melanosome;GO:0016020,membrane;GO:0045121,membrane raft;GO:0005739,mitochondrion;GO:0001917,photoreceptor inner segment;GO:0001750,photoreceptor outer segment;GO:0005886,plasma membrane;GO:0042383,sarcolemma;GO:0016021,integral component of membrane;GO:0016328,lateral plasma membrane	GO:0045296,cadherin binding;GO:0098632,cell-cell adhesion mediator activity;GO:0005537,mannose binding;GO:0038023,signaling receptor activity;GO:0001618,virus receptor activity	GO:0001525,angiogenesis;GO:0007411,axon guidance;GO:0007166,cell surface receptor signaling pathway;GO:0046697,decidualization;GO:0070593,dendrite self-avoidance;GO:0007566,embryo implantation;GO:0061154,endothelial tube morphogenesis;GO:0022617,extracellular matrix disassembly;GO:0030198,extracellular matrix organization;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0050900,leukocyte migration;GO:0003407,neural retina development;GO:0030593,neutrophil chemotaxis;GO:0042475,odontogenesis of dentin-containing tooth;GO:0045494,photoreceptor cell maintenance;GO:0010595,positive regulation of endothelial cell migration;GO:0032755,positive regulation of interleukin-6 production;GO:1904466,positive regulation of matrix metallopeptidase secretion;GO:0010575,positive regulation of vascular endothelial growth factor production;GO:0046598,positive regulation of viral entry into host cell;GO:0072659,protein localization to plasma membrane;GO:0006090,pyruvate metabolic process;GO:0051591,response to cAMP;GO:0046689,response to mercury ion;GO:0043434,response to peptide hormone;GO:0007155,cell adhesion	
GNL1_HUMAN	P36915	GNL1	Guanine nucleotide-binding protein-like 1	0.212675849	0.153303478	0.305082597	0.478540106	0.1829896635	0.3918113515	0.1829896635	0.3918113515	0.467035124938181	0.195121	0	2.14116657742255	0.195456	0	GO:0005615,extracellular space;GO:0005634,nucleus	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0005198,structural molecule activity;GO:0000166,nucleotide binding	GO:0006974,cellular response to DNA damage stimulus;GO:0007165,signal transduction;GO:0002456,T cell mediated immunity	
PX11B_HUMAN	O96011	PEX11B	Peroxisomal membrane protein 11B	0.482780635	0.395902139	0.357850608	0.029252718	0.439341387	0.193551663	0.439341387	0.193551663	2.26989208044159	0.195233	0	0.440549578817622	0.194670	0	GO:0005829,cytosol;GO:0005779,integral component of peroxisomal membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005778,peroxisomal membrane;GO:0005777,peroxisome;GO:0032991,protein-containing complex	GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity	GO:0016559,peroxisome fission;GO:0007031,peroxisome organization;GO:0045046,protein import into peroxisome membrane;GO:0044375,regulation of peroxisome size;GO:0007165,signal transduction	hsa:8799,path:hsa04146,Peroxisome
HM13_HUMAN	Q8TCT9	HM13	Minor histocompatibility antigen H13	2.194198965	1.13604123	3.115885048	1.884330596	1.6651200975	2.500107822	1.6651200975	2.500107822	0.666019314386194	0.375701	0	1.50145795835006	0.375925	0	GO:0009986,cell surface;GO:0036513,Derlin-1 retrotranslocation complex;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0071458,integral component of cytoplasmic side of endoplasmic reticulum membrane;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0005791,rough endoplasmic reticulum;GO:0016021,integral component of membrane	GO:0042500,aspartic endopeptidase activity, intramembrane cleaving;GO:0008233,peptidase activity;GO:0042803,protein homodimerization activity;GO:0031625,ubiquitin protein ligase binding;GO:0004190,aspartic-type endopeptidase activity	GO:0001701,in utero embryonic development;GO:0033619,membrane protein proteolysis;GO:1904211,membrane protein proteolysis involved in retrograde protein transport, ER to cytosol;GO:0006465,signal peptide processing	
AATM_HUMAN	P00505	GOT2	Aspartate aminotransferase, mitochondrial	9.903604491	7.272108942	10.95818929	6.50563025	8.5878567165	8.73190977	8.5878567165	8.73190977	0.983502686434654	0.438873	0	1.01677404016572	0.438688	0	GO:0009986,cell surface;GO:0070062,extracellular exosome;GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0043204,perikaryon;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0030315,T-tubule	GO:0016597,amino acid binding;GO:0031406,carboxylic acid binding;GO:0019899,enzyme binding;GO:0042802,identical protein binding;GO:0016212,kynurenine-oxoglutarate transaminase activity;GO:0004069,L-aspartate;GO:0005543,phospholipid binding;GO:0030170,pyridoxal phosphate binding;GO:0003723,RNA binding	GO:0006103,2-oxoglutarate metabolic process;GO:0019470,4-hydroxyproline catabolic process;GO:0006532,aspartate biosynthetic process;GO:0006533,aspartate catabolic process;GO:0009066,aspartate family amino acid metabolic process;GO:0006531,aspartate metabolic process;GO:0015908,fatty acid transport;GO:0007565,female pregnancy;GO:0006094,gluconeogenesis;GO:0019551,glutamate catabolic process to 2-oxoglutarate;GO:0019550,glutamate catabolic process to aspartate;GO:0006536,glutamate metabolic process;GO:0009064,glutamine family amino acid metabolic process;GO:0046487,glyoxylate metabolic process;GO:0007595,lactation;GO:0006107,oxaloacetate metabolic process;GO:0045471,response to ethanol;GO:0032868,response to insulin;GO:0043278,response to morphine;GO:0014850,response to muscle activity	hsa:2806,path:hsa00250,Alanine, aspartate and glutamate metabolism;hsa:2806,path:hsa00270,Cysteine and methionine metabolism;hsa:2806,path:hsa00220,Arginine biosynthesis;hsa:2806,path:hsa00330,Arginine and proline metabolism;hsa:2806,path:hsa00350,Tyrosine metabolism;hsa:2806,path:hsa00360,Phenylalanine metabolism;hsa:2806,path:hsa00400,Phenylalanine, tyrosine and tryptophan biosynthesis;hsa:2806,path:hsa04975,Fat digestion and absorption
FEN1_HUMAN	P39748	FEN1	Flap endonuclease 1	0.483872588	0.170937095	0.523960901	0.281818442	0.3274048415	0.4028896715	0.3274048415	0.4028896715	0.812641436751252	0.494925	0	1.23055502067156	0.495021	0	GO:0000781,chromosome, telomeric region;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0008409,5'-3' exonuclease activity;GO:0017108,5'-flap endonuclease activity;GO:0003684,damaged DNA binding;GO:0003677,DNA binding;GO:0003690,double-stranded DNA binding;GO:0008309,double-stranded DNA exodeoxyribonuclease activity;GO:0004519,endonuclease activity;GO:0004527,exonuclease activity;GO:0048256,flap endonuclease activity;GO:0000287,magnesium ion binding;GO:0030145,manganese ion binding;GO:0004523,RNA-DNA hybrid ribonuclease activity;GO:0004518,nuclease activity	GO:0006287,base-excision repair, gap-filling;GO:0006281,DNA repair;GO:0006260,DNA replication;GO:0043137,DNA replication, removal of RNA primer;GO:0006302,double-strand break repair;GO:0000724,double-strand break repair via homologous recombination;GO:0007613,memory;GO:0090305,nucleic acid phosphodiester bond hydrolysis;GO:0045876,positive regulation of sister chromatid cohesion;GO:0032201,telomere maintenance via semi-conservative replication;GO:0009650,UV protection	hsa:2237,path:hsa03030,DNA replication;hsa:2237,path:hsa03410,Base excision repair;hsa:2237,path:hsa03450,Non-homologous end-joining
PREP_HUMAN	Q5JRX3	PITRM1	Presequence protease, mitochondrial	0.867272838	0.374578782	1.360178819	0.861306948	0.62092581	1.1107428835	0.62092581	1.1107428835	0.559018490438971	0.279463	0	1.78884959460777	0.279765	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0008047,enzyme activator activity;GO:0004222,metalloendopeptidase activity;GO:0008237,metallopeptidase activity;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0016485,protein processing;GO:0006626,protein targeting to mitochondrion;GO:0006508,proteolysis	
LSM7_HUMAN	Q9UK45	LSM7	U6 snRNA-associated Sm-like protein LSm7	0.143332556	0.119192856	0.129966717	0.069034274	0.131262706	0.0995004955	0.131262706	0.0995004955	1.31921660631328	0.344080	0	0.75802563067685	0.343704	0	GO:0071013,catalytic step 2 spliceosome;GO:0005829,cytosol;GO:1990726,Lsm1-7-Pat1 complex;GO:0120115,Lsm2-8 complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0097526,spliceosomal tri-snRNP complex;GO:0005689,U12-type spliceosomal complex;GO:0071005,U2-type precatalytic spliceosome;GO:0071004,U2-type prespliceosome;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005688,U6 snRNP	GO:0017070,U6 snRNA binding	GO:0043928,exonucleolytic catabolism of deadenylated mRNA;GO:0000398,mRNA splicing, via spliceosome	hsa:51690,path:hsa03040,Spliceosome;hsa:51690,path:hsa03018,RNA degradation
GLYC_HUMAN	P34896	SHMT1	Serine hydroxymethyltransferase, cytosolic	0.140144786	0.377886258	0.254704728	0.093222335	0.259015522	0.1739635315	0.259015522	0.1739635315	1.48890701267467	0.307361	0	0.671633615455679	0.306922	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0050897,cobalt ion binding;GO:0004372,glycine hydroxymethyltransferase activity;GO:0042802,identical protein binding;GO:0008732,L-allo-threonine aldolase activity;GO:0048027,mRNA 5'-UTR binding;GO:0042803,protein homodimerization activity;GO:0030170,pyridoxal phosphate binding;GO:0070905,serine binding;GO:0036094,small molecule binding;GO:0000900,translation repressor activity, mRNA regulatory element binding;GO:0008270,zinc ion binding;GO:0004843,thiol-dependent deubiquitinase	GO:0045329,carnitine biosynthetic process;GO:1990830,cellular response to leukemia inhibitory factor;GO:1904482,cellular response to tetrahydrofolate;GO:0046655,folic acid metabolic process;GO:0019264,glycine biosynthetic process from serine;GO:0006544,glycine metabolic process;GO:0006565,L-serine catabolic process;GO:0006563,L-serine metabolic process;GO:0017148,negative regulation of translation;GO:0006730,one-carbon metabolic process;GO:0051289,protein homotetramerization;GO:0009113,purine nucleobase biosynthetic process;GO:0035999,tetrahydrofolate interconversion;GO:0046653,tetrahydrofolate metabolic process;GO:0016579,protein deubiquitination	hsa:6470,path:hsa00630,Glyoxylate and dicarboxylate metabolism;hsa:6470,path:hsa00260,Glycine, serine and threonine metabolism;hsa:6470,path:hsa00670,One carbon pool by folate;hsa:6470,path:hsa01523,Antifolate resistance
MIC26_HUMAN	Q9BUR5	APOO	MICOS complex subunit MIC26	0.47464766	0.917598168	0.038187496	0.012988093	0.696122914	0.0255877945	0.696122914	0.0255877945	27.2052721855336	0.001578	1	0.0367575811475156	0.001544	-1	GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0000139,Golgi membrane;GO:0034364,high-density lipoprotein particle;GO:0031305,integral component of mitochondrial inner membrane;GO:0034362,low-density lipoprotein particle;GO:0140275,MIB complex;GO:0061617,MICOS complex;GO:0005739,mitochondrion;GO:0001401,SAM complex;GO:0034361,very-low-density lipoprotein particle		GO:0042407,cristae formation;GO:0007007,inner mitochondrial membrane organization;GO:0006869,lipid transport	
UBF1_HUMAN	P17480	UBTF	Nucleolar transcription factor 1	0.044173352	0.059021521	0.064522044	0.174425214	0.0515974365	0.119473629	0.0515974365	0.119473629	0.431873016094623	0.163840	0	2.31549544132876	0.164175	0	GO:0001650,fibrillar center;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003682,chromatin binding;GO:0003723,RNA binding;GO:0001165,RNA polymerase I cis-regulatory region sequence-specific DNA binding;GO:0001164,RNA polymerase I core promoter sequence-specific DNA binding;GO:0001181,RNA polymerase I general transcription initiation factor activity;GO:0097110,scaffold protein binding;GO:0003677,DNA binding	GO:0045943,positive regulation of transcription by RNA polymerase I;GO:0006363,termination of RNA polymerase I transcription;GO:0006360,transcription by RNA polymerase I;GO:0006361,transcription initiation from RNA polymerase I promoter	
NUMA1_HUMAN	Q14980	NUMA1	Nuclear mitotic apparatus protein 1	3.359653238	3.844760886	4.667277819	7.443793345	3.602207062	6.055535582	3.602207062	6.055535582	0.594861843881739	0.312256	0	1.68106260350227	0.312536	0	GO:0005938,cell cortex;GO:0099738,cell cortex region;GO:0005813,centrosome;GO:0005694,chromosome;GO:0055028,cortical microtubule;GO:1905720,cytoplasmic microtubule bundle;GO:0005829,cytosol;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:0019897,extrinsic component of plasma membrane;GO:0000139,Golgi membrane;GO:0097575,lateral cell cortex;GO:0016328,lateral plasma membrane;GO:0097427,microtubule bundle;GO:0036449,microtubule minus-end;GO:0035371,microtubule plus-end;GO:0072686,mitotic spindle;GO:0061673,mitotic spindle astral microtubule;GO:1990023,mitotic spindle midzone;GO:0097431,mitotic spindle pole;GO:0043025,neuronal cell body;GO:0016363,nuclear matrix;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0005819,spindle;GO:0005876,spindle microtubule;GO:0000922,spindle pole;GO:0031616,spindle pole centrosome	GO:0097718,disordered domain specific binding;GO:0070840,dynein complex binding;GO:0008017,microtubule binding;GO:0051011,microtubule minus-end binding;GO:0051010,microtubule plus-end binding;GO:0035091,phosphatidylinositol binding;GO:0008022,protein C-terminus binding;GO:0019904,protein domain specific binding;GO:0044877,protein-containing complex binding;GO:0005198,structural molecule activity;GO:0015631,tubulin binding	GO:0055048,anastral spindle assembly;GO:0030953,astral microtubule organization;GO:0051301,cell division;GO:0007059,chromosome segregation;GO:0000132,establishment of mitotic spindle orientation;GO:0051321,meiotic cell cycle;GO:0001578,microtubule bundle formation;GO:0006997,nucleus organization;GO:0030513,positive regulation of BMP signaling pathway;GO:0051984,positive regulation of chromosome segregation;GO:1905820,positive regulation of chromosome separation;GO:0051798,positive regulation of hair follicle development;GO:0032388,positive regulation of intracellular transport;GO:0045618,positive regulation of keratinocyte differentiation;GO:0031116,positive regulation of microtubule polymerization;GO:1902846,positive regulation of mitotic spindle elongation;GO:1904778,positive regulation of protein localization to cell cortex;GO:1902365,positive regulation of protein localization to spindle pole body;GO:1905832,positive regulation of spindle assembly;GO:0090235,regulation of metaphase plate congression;GO:0060236,regulation of mitotic spindle organization	
AGK_HUMAN	Q53H12	AGK	Acylglycerol kinase, mitochondrial	1.921908343	0.371940768	0.653745101	0.205826843	1.1469245555	0.429785972	1.1469245555	0.429785972	2.66859467321097	0.159829	0	0.374729069962789	0.159258	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0031305,integral component of mitochondrial inner membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005758,mitochondrial intermembrane space;GO:0031966,mitochondrial membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0042721,TIM22 mitochondrial import inner membrane insertion complex	GO:0047620,acylglycerol kinase activity;GO:0005524,ATP binding;GO:0001729,ceramide kinase activity;GO:0017050,D-erythro-sphingosine kinase activity;GO:0004143,diacylglycerol kinase activity;GO:0102773,dihydroceramide kinase activity;GO:0001727,lipid kinase activity;GO:0003951,NAD+ kinase activity	GO:0046513,ceramide biosynthetic process;GO:0046474,glycerophospholipid biosynthetic process;GO:0016310,phosphorylation;GO:0045039,protein insertion into mitochondrial inner membrane;GO:0006665,sphingolipid metabolic process;GO:0046512,sphingosine biosynthetic process	hsa:55750,path:hsa00561,Glycerolipid metabolism
CTBP2_HUMAN	P56545	CTBP2	C-terminal-binding protein 2	0.561665996	0.292137755	0.634729705	0.81821188	0.4269018755	0.7264707925	0.4269018755	0.7264707925	0.587638043961692	0.305679	0	1.70172780723705	0.305963	0	GO:0098982,GABA-ergic synapse;GO:0098978,glutamatergic synapse;GO:0005634,nucleus;GO:0098684,photoreceptor ribbon synapse;GO:0098831,presynaptic active zone cytoplasmic component;GO:0099523,presynaptic cytosol;GO:0017053,transcription repressor complex	GO:0003682,chromatin binding;GO:0042802,identical protein binding;GO:0051287,NAD binding;GO:0016616,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0019901,protein kinase binding;GO:0044877,protein-containing complex binding;GO:0042974,retinoic acid receptor binding;GO:0001226,RNA polymerase II transcription corepressor binding;GO:0098882,structural constituent of presynaptic active zone;GO:0003713,transcription coactivator activity;GO:0003714,transcription corepressor activity	GO:1990830,cellular response to leukemia inhibitory factor;GO:0008285,negative regulation of cell population proliferation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0035563,positive regulation of chromatin binding;GO:0048386,positive regulation of retinoic acid receptor signaling pathway;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0016081,synaptic vesicle docking;GO:0019079,viral genome replication;GO:0050872,white fat cell differentiation	hsa:1488,path:hsa04310,Wnt signaling pathway;hsa:1488,path:hsa04330,Notch signaling pathway;hsa:1488,path:hsa05200,Pathways in cancer;hsa:1488,path:hsa05220,Chronic myeloid leukemia
EIF3A_HUMAN	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	11.59441274	10.36509605	11.43686333	12.11595355	10.979754395	11.77640844	10.979754395	11.77640844	0.932351697118956	0.456677	0	1.07255663618148	0.456530	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016282,eukaryotic 43S preinitiation complex;GO:0033290,eukaryotic 48S preinitiation complex;GO:0005852,eukaryotic translation initiation factor 3 complex;GO:0071540,eukaryotic translation initiation factor 3 complex, eIF3e;GO:0071541,eukaryotic translation initiation factor 3 complex, eIF3m;GO:0016020,membrane;GO:0005874,microtubule;GO:0043614,multi-eIF complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0014069,postsynaptic density	GO:0003729,mRNA binding;GO:0030971,receptor tyrosine kinase binding;GO:0003723,RNA binding;GO:0005198,structural molecule activity;GO:0003743,translation initiation factor activity	GO:0001732,formation of cytoplasmic translation initiation complex;GO:0075522,IRES-dependent viral translational initiation;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:0002188,translation reinitiation;GO:0006413,translational initiation;GO:0075525,viral translational termination-reinitiation	hsa:8661,path:hsa03013,RNA transport
SPSY_HUMAN	P52788	SMS	Spermine synthase	0.532810534	0.299145083	0.431383428	0.840233406	0.4159778085	0.635808417	0.4159778085	0.635808417	0.65425023855889	0.365409	0	1.5284671537953	0.365643	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0016768,spermine synthase activity	GO:0006555,methionine metabolic process;GO:0006595,polyamine metabolic process;GO:0006597,spermine biosynthetic process	hsa:6611,path:hsa00270,Cysteine and methionine metabolism;hsa:6611,path:hsa00330,Arginine and proline metabolism;hsa:6611,path:hsa00480,Glutathione metabolism
CALU_HUMAN	O43852	CALU	Calumenin	0.765970577	0.424359132	0.942272952	0.433509682	0.5951648545	0.687891317	0.5951648545	0.687891317	0.865201870981023	0.481731	0	1.15579962727789	0.481641	0	GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0005576,extracellular region;GO:0005794,Golgi apparatus;GO:0042470,melanosome;GO:0016020,membrane;GO:0033018,sarcoplasmic reticulum lumen	GO:0005509,calcium ion binding	GO:0044267,cellular protein metabolic process;GO:0043687,post-translational protein modification	
CUTA_HUMAN	O60888	CUTA	Protein CutA	1.482696537	3.337470805	0.415795859	2.55E-05	2.410083671	0.2079106795	2.410083671	0.2079106795	11.5919185911756	0.012770	1	0.0862669964539999	0.012603	-1	GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0016021,integral component of membrane	GO:0005507,copper ion binding;GO:0019899,enzyme binding	GO:0008104,protein localization;GO:0010038,response to metal ion	
WDR1_HUMAN	O75083	WDR1	WD repeat-containing protein 1	23.65046484	19.6517797	20.95446244	25.18715006	21.65112227	23.07080625	21.65112227	23.07080625	0.938464049993918	0.454493	0	1.06557091878637	0.454342	0	GO:0030054,cell junction;GO:0042995,cell projection;GO:0005911,cell-cell junction;GO:0030864,cortical actin cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005886,plasma membrane;GO:0002102,podosome	GO:0051015,actin filament binding	GO:0030042,actin filament depolymerization;GO:0030043,actin filament fragmentation;GO:0043297,apical junction assembly;GO:0030865,cortical cytoskeleton organization;GO:0042247,establishment of planar polarity of follicular epithelium;GO:0040011,locomotion;GO:0045199,maintenance of epithelial cell apical/basal polarity;GO:0002446,neutrophil mediated immunity;GO:1990266,neutrophil migration;GO:0002576,platelet degranulation;GO:0030220,platelet formation;GO:0030836,positive regulation of actin filament depolymerization;GO:0030834,regulation of actin filament depolymerization;GO:0008360,regulation of cell shape;GO:0048713,regulation of oligodendrocyte differentiation;GO:0060307,regulation of ventricular cardiac muscle cell membrane repolarization;GO:0045214,sarcomere organization;GO:0007605,sensory perception of sound	
3BP1_HUMAN	Q9Y3L3	SH3BP1	SH3 domain-binding protein 1	0.275680782	0.074238515	0.426837877	0.07909043	0.1749596485	0.2529641535	0.1749596485	0.2529641535	0.691638107926624	0.397775	0	1.4458428310114	0.397977	0	GO:0005912,adherens junction;GO:0005923,bicellular tight junction;GO:0031252,cell leading edge;GO:0005829,cytosol;GO:0030027,lamellipodium;GO:0005634,nucleus;GO:0001891,phagocytic cup	GO:0005096,GTPase activator activity;GO:0030215,semaphorin receptor binding;GO:0017124,SH3 domain binding	GO:0007015,actin filament organization;GO:0034329,cell junction assembly;GO:0016477,cell migration;GO:0045198,establishment of epithelial cell apical/basal polarity;GO:0046847,filopodium assembly;GO:0051058,negative regulation of small GTPase mediated signal transduction;GO:0006911,phagocytosis, engulfment;GO:0043547,positive regulation of GTPase activity;GO:0032956,regulation of actin cytoskeleton organization;GO:0030834,regulation of actin filament depolymerization;GO:0043535,regulation of blood vessel endothelial cell migration;GO:0035020,regulation of Rac protein signal transduction;GO:0097178,ruffle assembly;GO:0071526,semaphorin-plexin signaling pathway;GO:0007165,signal transduction	
ARP3_HUMAN	P61158	ACTR3	Actin-related protein 3	17.46095585	23.69646397	23.42788408	52.28921607	20.57870991	37.858550075	20.57870991	37.858550075	0.543568358250181	0.265241	0	1.83969501686804	0.265552	0	GO:0015629,actin cytoskeleton;GO:0005885,Arp2/3 protein complex;GO:0005903,brush border;GO:0005911,cell-cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0016020,membrane;GO:0005634,nucleus;GO:0035861,site of double-strand break;GO:0042995,cell projection	GO:0003779,actin binding;GO:0005524,ATP binding;GO:0005200,structural constituent of cytoskeleton	GO:0070358,actin polymerization-dependent cell motility;GO:0034314,Arp2/3 complex-mediated actin nucleation;GO:0008356,asymmetric cell division;GO:0071346,cellular response to interferon-gamma;GO:0060271,cilium assembly;GO:0048013,ephrin receptor signaling pathway;GO:0007163,establishment or maintenance of cell polarity;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0016344,meiotic chromosome movement towards spindle pole;GO:0033206,meiotic cytokinesis;GO:0061024,membrane organization;GO:0010592,positive regulation of lamellipodium assembly;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0051653,spindle localization	hsa:10096,path:hsa04530,Tight junction;hsa:10096,path:hsa05135,Yersinia infection
GPDA_HUMAN	P21695	GPD1	Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic	6.265426961	9.731849994	9.823569926	4.398694319	7.9986384775	7.1111321225	7.9986384775	7.1111321225	1.1248052124066	0.394743	0	0.889042821788166	0.394465	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0009331,glycerol-3-phosphate dehydrogenase complex	GO:0004368,glycerol-3-phosphate dehydrogenase (quinone) activity;GO:0004367,glycerol-3-phosphate dehydrogenase [NAD+] activity;GO:0051287,NAD binding;GO:0042803,protein homodimerization activity	GO:0071320,cellular response to cAMP;GO:0071356,cellular response to tumor necrosis factor;GO:0006094,gluconeogenesis;GO:0046168,glycerol-3-phosphate catabolic process;GO:0006072,glycerol-3-phosphate metabolic process;GO:0006127,glycerophosphate shuttle;GO:0006116,NADH oxidation;GO:0006654,phosphatidic acid biosynthetic process;GO:0045821,positive regulation of glycolytic process	hsa:2819,path:hsa00564,Glycerophospholipid metabolism
CLCA2_HUMAN	Q9UQC9	CLCA2	Calcium-activated chloride channel regulator 2	0.010283289	2.55E-05	0.01716288	0.034696299	0.0051543945	0.0259295895	0.0051543945	0.0259295895	0.198784269222619	0.015211	-1	5.03057914950049	0.015315	1	GO:0009925,basal plasma membrane;GO:0030054,cell junction;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0005887,integral component of plasma membrane;GO:0031965,nuclear membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0005254,chloride channel activity;GO:0005229,intracellular calcium activated chloride channel activity;GO:0015276,ligand-gated ion channel activity;GO:0046872,metal ion binding;GO:0008237,metallopeptidase activity	GO:0007155,cell adhesion;GO:0006821,chloride transport;GO:0034220,ion transmembrane transport	hsa:9635,path:hsa04924,Renin secretion;hsa:9635,path:hsa04972,Pancreatic secretion
SAA4_HUMAN	P35542	SAA4	Serum amyloid A-4 protein	3.136462798	214.4815074	1.425500498	1.699624395	108.808985099	1.5625624465	108.808985099	1.5625624465	69.6349674489633	0.000090	1	0.0143606012415087	0.000087	-1	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0034364,high-density lipoprotein particle		GO:0006953,acute-phase response	
EHD2_HUMAN	Q9NZN4	EHD2	EH domain-containing protein 2	1.786677228	4.577523335	9.981814982	63.21658048	3.1821002815	36.599197731	3.1821002815	36.599197731	0.0869445364591891	0.000304	-1	11.5015852717714	0.000308	1	GO:0005901,caveola;GO:0005829,cytosol;GO:0005769,early endosome;GO:0030139,endocytic vesicle;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0019898,extrinsic component of membrane;GO:0045171,intercellular bridge;GO:0043231,intracellular membrane-bounded organelle;GO:0015630,microtubule cytoskeleton;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane	GO:0005524,ATP binding;GO:0005509,calcium ion binding;GO:0005525,GTP binding;GO:0016787,hydrolase activity;GO:0042802,identical protein binding;GO:0003676,nucleic acid binding;GO:0019904,protein domain specific binding	GO:0007596,blood coagulation;GO:0060271,cilium assembly;GO:0030866,cortical actin cytoskeleton organization;GO:0032456,endocytic recycling;GO:0006897,endocytosis;GO:0016197,endosomal transport;GO:0097320,plasma membrane tubulation;GO:2001137,positive regulation of endocytic recycling;GO:1901741,positive regulation of myoblast fusion;GO:0072659,protein localization to plasma membrane	hsa:30846,path:hsa04144,Endocytosis
TMM65_HUMAN	Q6PI78	TMEM65	Transmembrane protein 65	0.631853256	0.997533618	0.064846485	0.024959533	0.814693437	0.044903009	0.814693437	0.044903009	18.1434040867952	0.004518	1	0.055116448667304	0.004439	-1	GO:0016021,integral component of membrane;GO:0014704,intercalated disc;GO:0005743,mitochondrial inner membrane;GO:0005886,plasma membrane		GO:0003231,cardiac ventricle development;GO:1903779,regulation of cardiac conduction	
IMA5_HUMAN	P52294	KPNA1	Importin subunit alpha-5	2.55E-05	0.189702653	2.55E-05	2.55E-05	0.0948640765	2.55e-005	0.0948640765	2.55e-005	3720.1598627451	0.000000	1	0.000268805652685609	0.000000	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0098978,glutamatergic synapse;GO:0043657,host cell;GO:0005643,nuclear pore;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0014069,postsynaptic density	GO:0061608,nuclear import signal receptor activity;GO:0008139,nuclear localization sequence binding	GO:0006309,apoptotic DNA fragmentation;GO:0075733,intracellular transport of virus;GO:0019054,modulation by virus of host cellular process;GO:0006607,NLS-bearing protein import into nucleus;GO:0099527,postsynapse to nucleus signaling pathway;GO:0042981,regulation of apoptotic process;GO:0060828,regulation of canonical Wnt signaling pathway;GO:0000018,regulation of DNA recombination;GO:0014901,satellite cell activation involved in skeletal muscle regeneration;GO:0014841,skeletal muscle satellite cell proliferation;GO:0006606,protein import into nucleus	hsa:3836,path:hsa05132,Salmonella infection;hsa:3836,path:hsa05164,Influenza A
HP1B3_HUMAN	Q5SSJ5	HP1BP3	Heterochromatin protein 1-binding protein 3	1.245222525	1.429359056	0.701476867	1.640174398	1.3372907905	1.1708256325	1.3372907905	1.1708256325	1.14217758253597	0.389779	0	0.875520597926379	0.389491	0	GO:0005694,chromosome;GO:0016607,nuclear speck;GO:0000786,nucleosome;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0031491,nucleosome binding;GO:0003682,chromatin binding	GO:0071456,cellular response to hypoxia;GO:0070828,heterochromatin organization;GO:0006334,nucleosome assembly;GO:0042127,regulation of cell population proliferation;GO:0097298,regulation of nucleus size;GO:0006355,regulation of transcription, DNA-templated	
TTHY_HUMAN	P02766	TTR	Transthyretin	3.288556517	7.920548452	1.365812689	0.763597407	5.6045524845	1.064705048	5.6045524845	1.064705048	5.26394844753286	0.058470	0	0.189971465330115	0.058048	0	GO:0035578,azurophil granule lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0032991,protein-containing complex	GO:0005179,hormone activity;GO:0042802,identical protein binding;GO:0044877,protein-containing complex binding;GO:0070324,thyroid hormone binding	GO:1990000,amyloid fibril formation;GO:0030198,extracellular matrix organization;GO:0043312,neutrophil degranulation;GO:0006144,purine nucleobase metabolic process;GO:0001523,retinoid metabolic process;GO:0042572,retinol metabolic process;GO:0070327,thyroid hormone transport	hsa:7276,path:hsa04918,Thyroid hormone synthesis
RPB2_HUMAN	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.542117989	0.386348768	0.719782798	1.268779395	0.4642333785	0.9942810965	0.4642333785	0.9942810965	0.466903554874132	0.195002	0	2.14176994276597	0.195338	0	GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005665,RNA polymerase II, core complex	GO:0003682,chromatin binding;GO:0003677,DNA binding;GO:0003899,DNA-directed 5'-3' RNA polymerase activity;GO:0046872,metal ion binding;GO:0032549,ribonucleoside binding;GO:0003723,RNA binding	GO:0006370,7-methylguanosine mRNA capping;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0000398,mRNA splicing, via spliceosome;GO:0048239,negative regulation of DNA recombination at telomere;GO:0050434,positive regulation of viral transcription;GO:0060964,regulation of gene silencing by miRNA;GO:0016070,RNA metabolic process;GO:0042795,snRNA transcription by RNA polymerase II;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter;GO:0006367,transcription initiation from RNA polymerase II promoter;GO:0006351,transcription, DNA-templated;GO:0006283,transcription-coupled nucleotide-excision repair	hsa:5431,path:hsa03020,RNA polymerase;hsa:5431,path:hsa05016,Huntington disease
WDR82_HUMAN	Q6UXN9	WDR82	WD repeat-containing protein 82	0.309609903	0.213844852	0.32490414	0.148048489	0.2617273775	0.2364763145	0.2617273775	0.2364763145	1.10678051649016	0.399994	0	0.903521506839688	0.399727	0	GO:0000785,chromatin;GO:0035097,histone methyltransferase complex;GO:0005730,nucleolus;GO:0072357,PTW/PP1 phosphatase complex;GO:0048188,Set1C/COMPASS complex	GO:0003682,chromatin binding	GO:0051568,histone H3-K4 methylation;GO:0080182,histone H3-K4 trimethylation	hsa:80335,path:hsa03015,mRNA surveillance pathway
FA98B_HUMAN	Q52LJ0	FAM98B	Protein FAM98B	0.174611045	0.097855699	0.213764308	0.20785231	0.136233372	0.210808309	0.136233372	0.210808309	0.646242895482834	0.358356	0	1.54740579275979	0.358596	0	GO:0005737,cytoplasm;GO:0043231,intracellular membrane-bounded organelle;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0072669,tRNA-splicing ligase complex	GO:0042802,identical protein binding;GO:0008276,protein methyltransferase activity;GO:0003723,RNA binding	GO:0008284,positive regulation of cell population proliferation;GO:0010628,positive regulation of gene expression;GO:0006479,protein methylation;GO:0006388,tRNA splicing, via endonucleolytic cleavage and ligation	
OLFL1_HUMAN	Q6UWY5	OLFML1	Olfactomedin-like protein 1	0.088305322	0.152365013	0.3957192	5.388822492	0.1203351675	2.892270846	0.1203351675	2.892270846	0.0416057741156652	0.000003	-1	24.0351254424439	0.000003	1	GO:0005576,extracellular region			
PANK4_HUMAN	Q9NVE7	PANK4	4'-phosphopantetheine phosphatase	0.170114214	0.185564758	0.145937817	0.320123842	0.177839486	0.2330308295	0.177839486	0.2330308295	0.763158618889952	0.456708	0	1.31034358421391	0.456848	0	GO:0005829,cytosol;GO:0005634,nucleus;GO:0005737,cytoplasm	GO:0005524,ATP binding;GO:0016787,hydrolase activity;GO:0046872,metal ion binding;GO:0004594,pantothenate kinase activity	GO:0015937,coenzyme A biosynthetic process;GO:0016310,phosphorylation	hsa:55229,path:hsa00770,Pantothenate and CoA biosynthesis
APOA4_HUMAN	P06727	APOA4	Apolipoprotein A-IV	1.977367578	3.610083739	3.373765818	14.41288205	2.7937256585	8.893323934	2.7937256585	8.893323934	0.314137400057961	0.071429	0	3.18332041907615	0.071690	0	GO:0072562,blood microparticle;GO:0042627,chylomicron;GO:0062023,collagen-containing extracellular matrix;GO:0005829,cytosol;GO:0005769,early endosome;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0034364,high-density lipoprotein particle;GO:0034361,very-low-density lipoprotein particle	GO:0016209,antioxidant activity;GO:0015485,cholesterol binding;GO:0120020,cholesterol transfer activity;GO:0005507,copper ion binding;GO:0042802,identical protein binding;GO:0008289,lipid binding;GO:0005319,lipid transporter activity;GO:0031210,phosphatidylcholine binding;GO:0060228,phosphatidylcholine-sterol O-acyltransferase activator activity;GO:0005543,phospholipid binding;GO:0042803,protein homodimerization activity	GO:1990000,amyloid fibril formation;GO:0006695,cholesterol biosynthetic process;GO:0033344,cholesterol efflux;GO:0042632,cholesterol homeostasis;GO:0008203,cholesterol metabolic process;GO:0034378,chylomicron assembly;GO:0034371,chylomicron remodeling;GO:0034380,high-density lipoprotein particle assembly;GO:0034375,high-density lipoprotein particle remodeling;GO:0042744,hydrogen peroxide catabolic process;GO:0002227,innate immune response in mucosa;GO:0007159,leukocyte cell-cell adhesion;GO:0016042,lipid catabolic process;GO:0055088,lipid homeostasis;GO:0006869,lipid transport;GO:0042157,lipoprotein metabolic process;GO:0034445,negative regulation of plasma lipoprotein oxidation;GO:0046470,phosphatidylcholine metabolic process;GO:0033700,phospholipid efflux;GO:0010873,positive regulation of cholesterol esterification;GO:0045723,positive regulation of fatty acid biosynthetic process;GO:0046889,positive regulation of lipid biosynthetic process;GO:0051006,positive regulation of lipoprotein lipase activity;GO:0010898,positive regulation of triglyceride catabolic process;GO:0065005,protein-lipid complex assembly;GO:0032374,regulation of cholesterol transport;GO:0030300,regulation of intestinal cholesterol absorption;GO:0019430,removal of superoxide radicals;GO:0006982,response to lipid hydroperoxide;GO:0035634,response to stilbenoid;GO:0001523,retinoid metabolic process;GO:0043691,reverse cholesterol transport;GO:0070328,triglyceride homeostasis;GO:0034372,very-low-density lipoprotein particle remodeling	hsa:337,path:hsa04975,Fat digestion and absorption;hsa:337,path:hsa04979,Cholesterol metabolism;hsa:337,path:hsa04977,Vitamin digestion and absorption
PALLD_HUMAN	Q8WX93	PALLD	Palladin	7.862815505	7.512195691	3.292979743	7.963412441	7.687505598	5.628196092	7.687505598	5.628196092	1.36589157028966	0.333358	0	0.73212253574999	0.332963	0	GO:0015629,actin cytoskeleton;GO:0005884,actin filament;GO:0030424,axon;GO:0005829,cytosol;GO:0060076,excitatory synapse;GO:0005925,focal adhesion;GO:0030426,growth cone;GO:0030027,lamellipodium;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0002102,podosome;GO:0001726,ruffle;GO:0001725,stress fiber;GO:0030018,Z disc	GO:0003779,actin binding;GO:0098632,cell-cell adhesion mediator activity;GO:0051371,muscle alpha-actinin binding	GO:0030036,actin cytoskeleton organization;GO:0007411,axon guidance;GO:0016477,cell migration;GO:0007010,cytoskeleton organization;GO:0070593,dendrite self-avoidance;GO:0003382,epithelial cell morphogenesis;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0003334,keratinocyte development	
LRC47_HUMAN	Q8N1G4	LRRC47	Leucine-rich repeat-containing protein 47	2.043617583	0.807268803	1.760977045	1.175167287	1.425443193	1.468072166	1.425443193	1.468072166	0.970962617514812	0.443140	0	1.02990576770042	0.442965	0		GO:0004826,phenylalanine-tRNA ligase activity;GO:0003723,RNA binding		
CD109_HUMAN	Q6YHK3	CD109	CD109 antigen	0.434902348	0.497131559	0.593986321	5.158715558	0.4660169535	2.8763509395	0.4660169535	2.8763509395	0.162016723029287	0.006623	-1	6.17220235851355	0.006680	1	GO:0031225,anchored component of membrane;GO:0009986,cell surface;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane;GO:0031092,platelet alpha granule membrane	GO:0004867,serine-type endopeptidase inhibitor activity;GO:0050431,transforming growth factor beta binding	GO:0001942,hair follicle development;GO:0010839,negative regulation of keratinocyte proliferation;GO:0001933,negative regulation of protein phosphorylation;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0061045,negative regulation of wound healing;GO:0072675,osteoclast fusion;GO:0002576,platelet degranulation;GO:0045616,regulation of keratinocyte differentiation	
SNUT1_HUMAN	O43290	SART1	U4/U6.U5 tri-snRNP-associated protein 1	0.490973594	2.55E-05	0.422949327	0.23705331	0.245499547	0.3300013185	0.245499547	0.3300013185	0.743935048853449	0.441283	0	1.34420337036304	0.441439	0	GO:0015030,Cajal body;GO:0071013,catalytic step 2 spliceosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0071005,U2-type precatalytic spliceosome;GO:0046540,U4/U6 x U5 tri-snRNP complex	GO:0003723,RNA binding	GO:0000481,maturation of 5S rRNA;GO:0045292,mRNA cis splicing, via spliceosome;GO:0000398,mRNA splicing, via spliceosome;GO:0045585,positive regulation of cytotoxic T cell differentiation;GO:0000387,spliceosomal snRNP assembly	hsa:9092,path:hsa03040,Spliceosome
HEM6_HUMAN	P36551	CPOX	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial	0.591385624	0.31496007	0.887750145	0.433911056	0.453172847	0.6608306005	0.453172847	0.6608306005	0.685762503517723	0.392754	0	1.45823079399989	0.392961	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005758,mitochondrial intermembrane space;GO:0005739,mitochondrion;GO:0016021,integral component of membrane	GO:0004109,coproporphyrinogen oxidase activity;GO:0042803,protein homodimerization activity	GO:0006783,heme biosynthetic process;GO:0006782,protoporphyrinogen IX biosynthetic process;GO:0006779,porphyrin-containing compound biosynthetic process	hsa:1371,path:hsa00860,Porphyrin and chlorophyll metabolism
THIO_HUMAN	P10599	TXN	Thioredoxin	8.501395659	10.522103	4.046231516	3.298239742	9.5117493295	3.672235629	9.5117493295	3.672235629	2.59017946843737	0.166017	0	0.386073633964557	0.165447	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0015037,peptide disulfide oxidoreductase activity;GO:0015035,protein disulfide oxidoreductase activity;GO:0042803,protein homodimerization activity;GO:0047134,protein-disulfide reductase activity;GO:0003723,RNA binding	GO:0032148,activation of protein kinase B activity;GO:0045454,cell redox homeostasis;GO:0006662,glycerol ether metabolic process;GO:1903206,negative regulation of hydrogen peroxide-induced cell death;GO:0046826,negative regulation of protein export from nucleus;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0043388,positive regulation of DNA binding;GO:2000170,positive regulation of peptidyl-cysteine S-nitrosylation;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0051897,positive regulation of protein kinase B signaling;GO:0035590,purinergic nucleotide receptor signaling pathway;GO:0071731,response to nitric oxide;GO:0009314,response to radiation	hsa:7295,path:hsa04621,NOD-like receptor signaling pathway;hsa:7295,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:7295,path:hsa05132,Salmonella infection
MTCH1_HUMAN	Q9NZJ7	MTCH1	Mitochondrial carrier homolog 1	0.19275133	0.539524829	0.386076112	0.396530519	0.3661380795	0.3913033155	0.3661380795	0.3913033155	0.935688671669331	0.455483	0	1.06873154530762	0.455334	0	GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion		GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006915,apoptotic process;GO:0045161,neuronal ion channel clustering;GO:0043065,positive regulation of apoptotic process;GO:0009966,regulation of signal transduction	
GSTK1_HUMAN	Q9Y2Q3	GSTK1	Glutathione S-transferase kappa 1	0.772233566	10.6566904	1.336141217	1.450189041	5.714461983	1.393165129	5.714461983	1.393165129	4.1017836752071	0.087314	0	0.243796377182058	0.086814	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005782,peroxisomal matrix;GO:0005777,peroxisome	GO:0004602,glutathione peroxidase activity;GO:0004364,glutathione transferase activity;GO:0016491,oxidoreductase activity	GO:0030855,epithelial cell differentiation;GO:1901687,glutathione derivative biosynthetic process;GO:0006749,glutathione metabolic process;GO:0008104,protein localization	hsa:373156,path:hsa00480,Glutathione metabolism;hsa:373156,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:373156,path:hsa00982,Drug metabolism - cytochrome P450;hsa:373156,path:hsa04146,Peroxisome;hsa:373156,path:hsa05204,Chemical carcinogenesis
AP3S1_HUMAN	Q92572	AP3S1	AP-3 complex subunit sigma-1	0.833755656	2.559911239	0.152171734	0.068316608	1.6968334475	0.110244171	1.6968334475	0.110244171	15.3915933342181	0.006716	1	0.0649705315288465	0.006611	-1	GO:0030123,AP-3 adaptor complex;GO:0030119,AP-type membrane coat adaptor complex;GO:1904115,axon cytoplasm;GO:0030659,cytoplasmic vesicle membrane;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0030133,transport vesicle;GO:0030117,membrane coat		GO:0008089,anterograde axonal transport;GO:0048490,anterograde synaptic vesicle transport;GO:0008286,insulin receptor signaling pathway;GO:0006886,intracellular protein transport;GO:0016192,vesicle-mediated transport	hsa:1176,path:hsa04142,Lysosome
FAS_HUMAN	P49327	FASN	Fatty acid synthase	20.58786414	20.43975008	42.97426074	18.42427383	20.51380711	30.699267285	20.51380711	30.699267285	0.668218134314341	0.377613	0	1.49651730273094	0.377836	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0042587,glycogen granule;GO:0005794,Golgi apparatus;GO:0042470,melanosome;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0008659,(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity;GO:0008693,3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity;GO:0047451,3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity;GO:0004317,3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity;GO:0102131,3-oxo-glutaryl-[acp] methyl ester reductase activity;GO:0102132,3-oxo-pimeloyl-[acp] methyl ester reductase activity;GO:0004316,3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity;GO:0004315,3-oxoacyl-[acyl-carrier-protein] synthase activity;GO:0004313,[acyl-carrier-protein] S-acetyltransferase activity;GO:0004314,[acyl-carrier-protein] S-malonyltransferase activity;GO:0045296,cadherin binding;GO:0047117,enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity;GO:0042802,identical protein binding;GO:0016295,myristoyl-[acyl-carrier-protein] hydrolase activity;GO:0004320,oleoyl-[acyl-carrier-protein] hydrolase activity;GO:0016296,palmitoyl-[acyl-carrier-protein] hydrolase activity;GO:0031177,phosphopantetheine binding;GO:0003723,RNA binding;GO:0016746,transferase activity, transferring acyl groups	GO:0006084,acetyl-CoA metabolic process;GO:0071353,cellular response to interleukin-4;GO:0090557,establishment of endothelial intestinal barrier;GO:0008611,ether lipid biosynthetic process;GO:0006633,fatty acid biosynthetic process;GO:0006631,fatty acid metabolic process;GO:0046949,fatty-acyl-CoA biosynthetic process;GO:0002068,glandular epithelial cell development;GO:0030522,intracellular receptor signaling pathway;GO:0030879,mammary gland development;GO:0030224,monocyte differentiation;GO:0030223,neutrophil differentiation;GO:0001649,osteoblast differentiation;GO:0031325,positive regulation of cellular metabolic process;GO:0019216,regulation of lipid metabolic process	hsa:2194,path:hsa00061,Fatty acid biosynthesis;hsa:2194,path:hsa04152,AMPK signaling pathway;hsa:2194,path:hsa04910,Insulin signaling pathway
ARM10_HUMAN	Q8N2F6	ARMC10	Armadillo repeat-containing protein 10	0.192802886	0.185137475	0.196171717	0.240329093	0.1889701805	0.218250405	0.1889701805	0.218250405	0.865841144716318	0.481483	0	1.15494626941948	0.481392	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0005739,mitochondrion	GO:0050692,DNA binding domain binding;GO:0002039,p53 binding	GO:0043066,negative regulation of apoptotic process;GO:1902254,negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:0040010,positive regulation of growth rate;GO:0040008,regulation of growth	
H2B2C_HUMAN	Q6DN03	H2BC20P	Putative histone H2B type 2-C	11.5391492	20.30952259	1.771750991	1.088158982	15.924335895	1.4299549865	15.924335895	1.4299549865	11.1362497738316	0.013928	1	0.0897968364852806	0.013750	-1	GO:0000786,nucleosome;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0046982,protein heterodimerization activity	GO:0006334,nucleosome assembly	
ERG28_HUMAN	Q9UKR5	ERG28	Ergosterol biosynthetic protein 28 homolog	0.436773463	0.910833414	0.344411687	0.680546495	0.6738034385	0.512479091	0.6738034385	0.512479091	1.31479205753587	0.345123	0	0.760576544609011	0.344749	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0030133,transport vesicle	GO:0042802,identical protein binding;GO:0030674,protein-macromolecule adaptor activity	GO:0016126,sterol biosynthetic process	
UFL1_HUMAN	O94874	UFL1	E3 UFM1-protein ligase 1	2.271505081	1.265194698	3.025253121	1.942914481	1.7683498895	2.484083801	1.7683498895	2.484083801	0.711872074842293	0.414866	0	1.40474677310743	0.415051	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016020,membrane;GO:0043005,neuron projection;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0035861,site of double-strand break	GO:0019901,protein kinase binding;GO:0061666,UFM1 ligase activity;GO:0071568,UFM1 transferase activity	GO:0006974,cellular response to DNA damage stimulus;GO:0006281,DNA repair;GO:0030218,erythrocyte differentiation;GO:0060218,hematopoietic stem cell differentiation;GO:0016570,histone modification;GO:0043066,negative regulation of apoptotic process;GO:1903895,negative regulation of IRE1-mediated unfolded protein response;GO:0032088,negative regulation of NF-kappaB transcription factor activity;GO:0031397,negative regulation of protein ubiquitination;GO:0001649,osteoblast differentiation;GO:0010508,positive regulation of autophagy;GO:0008284,positive regulation of cell population proliferation;GO:0060252,positive regulation of glial cell proliferation;GO:1990592,protein K69-linked ufmylation;GO:0071569,protein ufmylation;GO:0043122,regulation of I-kappaB kinase/NF-kappaB signaling;GO:0050727,regulation of inflammatory response;GO:0033146,regulation of intracellular estrogen receptor signaling pathway;GO:0032434,regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032880,regulation of protein localization;GO:0034976,response to endoplasmic reticulum stress;GO:1902065,response to L-glutamate;GO:0061709,reticulophagy	
GALM_HUMAN	Q96C23	GALM	Galactose mutarotase	0.452535192	0.504348434	1.115877152	0.860337341	0.478441813	0.9881072465	0.478441813	0.9881072465	0.484200287665839	0.210693	0	2.06526106132785	0.211026	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome	GO:0004034,aldose 1-epimerase activity;GO:0030246,carbohydrate binding	GO:0005975,carbohydrate metabolic process;GO:0033499,galactose catabolic process via UDP-galactose;GO:0006012,galactose metabolic process;GO:0006006,glucose metabolic process	hsa:130589,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:130589,path:hsa00052,Galactose metabolism
S100P_HUMAN	P25815	S100P	Protein S100-P	0.301306997	0.079239198	0.040549472	0.190461118	0.1902730975	0.115505295	0.1902730975	0.115505295	1.64731060597698	0.278079	0	0.607050058666334	0.277596	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0031528,microvillus membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0034774,secretory granule lumen	GO:0045296,cadherin binding;GO:0005509,calcium ion binding;GO:0048306,calcium-dependent protein binding;GO:0000287,magnesium ion binding;GO:0042803,protein homodimerization activity;GO:0046914,transition metal ion binding	GO:0043542,endothelial cell migration;GO:0043312,neutrophil degranulation;GO:0010033,response to organic substance	
CELF1_HUMAN	Q92879	CELF1	CUGBP Elav-like family member 1	0.278372051	0.071321613	0.140108267	2.55E-05	0.174846832	0.0700668835	0.174846832	0.0700668835	2.49542755815592	0.173965	0	0.400732931209185	0.173395	0	GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0097356,perinucleolar compartment;GO:1990904,ribonucleoprotein complex	GO:0042835,BRE binding;GO:0003730,mRNA 3'-UTR binding;GO:0003729,mRNA binding;GO:0036002,pre-mRNA binding;GO:0003723,RNA binding;GO:0000900,translation repressor activity, mRNA regulatory element binding;GO:0031369,translation initiation factor binding	GO:0009792,embryo development ending in birth or egg hatching;GO:0007281,germ cell development;GO:0061157,mRNA destabilization;GO:0006397,mRNA processing;GO:0006376,mRNA splice site selection;GO:0008285,negative regulation of cell population proliferation;GO:0010629,negative regulation of gene expression;GO:0010942,positive regulation of cell death;GO:0010628,positive regulation of gene expression;GO:0016441,posttranscriptional gene silencing;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0050727,regulation of inflammatory response;GO:0043484,regulation of RNA splicing;GO:0016246,RNA interference;GO:0021987,cerebral cortex development;GO:0071158,positive regulation of cell cycle arrest;GO:0040018,positive regulation of multicellular organism growth;GO:0007286,spermatid development	
GMIP_HUMAN	Q9P107	GMIP	GEM-interacting protein	0.047792921	0.079408377	0.130000553	0.168983591	0.063600649	0.149492072	0.063600649	0.149492072	0.425444962726853	0.158241	0	2.35048029148256	0.158574	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0005096,GTPase activator activity;GO:0046872,metal ion binding	GO:0090630,activation of GTPase activity;GO:0035556,intracellular signal transduction;GO:0034260,negative regulation of GTPase activity;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0043547,positive regulation of GTPase activity	
MSI2H_HUMAN	Q96DH6	MSI2	RNA-binding protein Musashi homolog 2	0.264362044	0.060155205	0.290629762	0.129568575	0.1622586245	0.2100991685	0.1622586245	0.2100991685	0.772295414867385	0.463928	0	1.29484130133249	0.464060	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0005844,polysome	GO:0042802,identical protein binding;GO:0003723,RNA binding		hsa:124540,path:hsa03015,mRNA surveillance pathway
RL10A_HUMAN	P62906	RPL10A	60S ribosomal protein L10a	5.914664072	29.35888473	1.475995959	0.906564952	17.636774401	1.1912804555	17.636774401	1.1912804555	14.8048885714301	0.007357	1	0.0675452567694269	0.007245	-1	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005634,nucleus;GO:0042788,polysomal ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000470,maturation of LSU-rRNA;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:4736,path:hsa03010,Ribosome
DDX42_HUMAN	Q86XP3	DDX42	ATP-dependent RNA helicase DDX42	0.762676466	0.228518242	0.633179596	0.263646856	0.495597354	0.448413226	0.495597354	0.448413226	1.10522465722276	0.400453	0	0.90479342228288	0.400186	0	GO:0015030,Cajal body;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0016787,hydrolase activity;GO:0003676,nucleic acid binding	GO:0000398,mRNA splicing, via spliceosome;GO:0008104,protein localization;GO:0042981,regulation of apoptotic process	hsa:11325,path:hsa03040,Spliceosome
MUC1_HUMAN	P15941	MUC1	Mucin-1	0.159546393	0.287322867	0.872523612	0.224247454	0.22343463	0.548385533	0.22343463	0.548385533	0.407440781265103	0.142807	0	2.45434440041814	0.143135	0	GO:0016324,apical plasma membrane;GO:0000785,chromatin;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005796,Golgi lumen;GO:0005887,integral component of plasma membrane;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0031982,vesicle;GO:0016021,integral component of membrane	GO:0002039,p53 binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003712,transcription coregulator activity	GO:0019221,cytokine-mediated signaling pathway;GO:0006977,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0006978,DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0033629,negative regulation of cell adhesion mediated by integrin;GO:1902166,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0010944,negative regulation of transcription by competitive promoter binding;GO:0016266,O-glycan processing;GO:0090240,positive regulation of histone H4 acetylation;GO:0036003,positive regulation of transcription from RNA polymerase II promoter in response to stress;GO:0043618,regulation of transcription from RNA polymerase II promoter in response to stress;GO:0002223,stimulatory C-type lectin receptor signaling pathway	
TRY3_HUMAN	P35030	PRSS3	Trypsin-3	1.594374354	0.466754914	0.600302844	3.90035366	1.030564634	2.250328252	1.030564634	2.250328252	0.45796191426032	0.186959	0	2.18358769334598	0.187294	0	GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904724,tertiary granule lumen	GO:0005509,calcium ion binding;GO:0004252,serine-type endopeptidase activity;GO:0008236,serine-type peptidase activity	GO:0019730,antimicrobial humoral response;GO:0009235,cobalamin metabolic process;GO:0007586,digestion;GO:0043542,endothelial cell migration;GO:0043312,neutrophil degranulation;GO:0006508,proteolysis;GO:0031638,zymogen activation	hsa:5646,path:hsa04080,Neuroactive ligand-receptor interaction;hsa:5646,path:hsa04972,Pancreatic secretion;hsa:5646,path:hsa04974,Protein digestion and absorption;hsa:5646,path:hsa05164,Influenza A
RM49_HUMAN	Q13405	MRPL49	39S ribosomal protein L49, mitochondrial	0.175756468	0.269268041	0.01678229	0.003371109	0.2225122545	0.0100766995	0.2225122545	0.0100766995	22.0818586978802	0.002749	1	0.0452860428862357	0.002696	-1	GO:0005743,mitochondrial inner membrane;GO:0005762,mitochondrial large ribosomal subunit;GO:0005761,mitochondrial ribosome;GO:0005739,mitochondrion;GO:0005840,ribosome	GO:0003735,structural constituent of ribosome	GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination;GO:0006412,translation	
VPS16_HUMAN	Q9H269	VPS16	Vacuolar protein sorting-associated protein 16 homolog	0.150933815	0.173806791	0.073782961	0.096216087	0.162370303	0.084999524	0.162370303	0.084999524	1.91024955622104	0.237806	0	0.523491811184216	0.237275	0	GO:0005776,autophagosome;GO:0030424,axon;GO:0030136,clathrin-coated vesicle;GO:0005769,early endosome;GO:0005768,endosome;GO:0030897,HOPS complex;GO:0005770,late endosome;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0043025,neuronal cell body;GO:0055037,recycling endosome;GO:0005737,cytoplasm	GO:0003779,actin binding;GO:0051015,actin filament binding	GO:0097352,autophagosome maturation;GO:0016197,endosomal transport;GO:0008333,endosome to lysosome transport;GO:0006886,intracellular protein transport;GO:0042144,vacuole fusion, non-autophagic;GO:0007033,vacuole organization	hsa:64601,path:hsa05132,Salmonella infection
ROA0_HUMAN	Q13151	HNRNPA0	Heterogeneous nuclear ribonucleoprotein A0	0.740100806	1.457954458	0.720881079	0.126210736	1.099027632	0.4235459075	1.099027632	0.4235459075	2.59482528939322	0.165641	0	0.3853824009222	0.165071	0	GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0035925,mRNA 3'-UTR AU-rich region binding;GO:0003729,mRNA binding;GO:0019901,protein kinase binding;GO:0003723,RNA binding	GO:0070935,3'-UTR-mediated mRNA stabilization;GO:0006954,inflammatory response;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0032496,response to lipopolysaccharide;GO:0016070,RNA metabolic process	
TARB1_HUMAN	Q13395	TARBP1	Probable methyltransferase TARBP1	0.090262455	0.077003668	0.110089735	0.145658898	0.0836330615	0.1278743165	0.0836330615	0.1278743165	0.654025482122518	0.365211	0	1.52899241288686	0.365445	0	GO:0005634,nucleus	GO:0003723,RNA binding;GO:0016423,tRNA (guanine) methyltransferase activity	GO:0006357,regulation of transcription by RNA polymerase II;GO:0030488,tRNA methylation	
LCK_HUMAN	P06239	LCK	Tyrosine-protein kinase Lck	2.55E-05	0.017854571	0.120968814	2.55E-05	0.0089400355	0.060497157	0.0089400355	0.060497157	0.147776126074817	0.004426	-1	6.76699292748893	0.004468	1	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0001772,immunological synapse;GO:0045121,membrane raft;GO:0000242,pericentriolar material;GO:0005886,plasma membrane	GO:0005524,ATP binding;GO:0051117,ATPase binding;GO:0042609,CD4 receptor binding;GO:0042610,CD8 receptor binding;GO:0042802,identical protein binding;GO:0004715,non-membrane spanning protein tyrosine kinase activity;GO:0043548,phosphatidylinositol 3-kinase binding;GO:0016004,phospholipase activator activity;GO:0043274,phospholipase binding;GO:0001784,phosphotyrosine residue binding;GO:0008022,protein C-terminus binding;GO:0019901,protein kinase binding;GO:0019903,protein phosphatase binding;GO:0004722,protein serine/threonine phosphatase activity;GO:0004713,protein tyrosine kinase activity;GO:0042169,SH2 domain binding;GO:0005102,signaling receptor binding;GO:0042608,T cell receptor binding;GO:0004714,transmembrane receptor protein tyrosine kinase activity	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0050853,B cell receptor signaling pathway;GO:0030154,cell differentiation;GO:0006882,cellular zinc ion homeostasis;GO:0019221,cytokine-mediated signaling pathway;GO:0030097,hemopoiesis;GO:0045087,innate immune response;GO:0035556,intracellular signal transduction;GO:0050900,leukocyte migration;GO:0018108,peptidyl-tyrosine phosphorylation;GO:0030168,platelet activation;GO:0034116,positive regulation of heterotypic cell-cell adhesion;GO:2001244,positive regulation of intrinsic apoptotic signaling pathway;GO:1903039,positive regulation of leukocyte cell-cell adhesion;GO:0051897,positive regulation of protein kinase B signaling;GO:0050870,positive regulation of T cell activation;GO:0050862,positive regulation of T cell receptor signaling pathway;GO:0006468,protein phosphorylation;GO:0050690,regulation of defense response to virus by virus;GO:0051249,regulation of lymphocyte activation;GO:0051209,release of sequestered calcium ion into cytosol;GO:0042493,response to drug;GO:0031295,T cell costimulation;GO:0030217,T cell differentiation;GO:0050852,T cell receptor signaling pathway;GO:0007169,transmembrane receptor protein tyrosine kinase signaling pathway	hsa:3932,path:hsa04064,NF-kappa B signaling pathway;hsa:3932,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3932,path:hsa04660,T cell receptor signaling pathway;hsa:3932,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3932,path:hsa04659,Th17 cell differentiation;hsa:3932,path:hsa04380,Osteoclast differentiation;hsa:3932,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:3932,path:hsa05340,Primary immunodeficiency;hsa:3932,path:hsa05135,Yersinia infection;hsa:3932,path:hsa05166,Human T-cell leukemia virus 1 infection
BLVRB_HUMAN	P30043	BLVRB	Flavin reductase (NADPH)	11.32886072	45.45372562	12.65086303	21.78677506	28.39129317	17.218819045	28.39129317	17.218819045	1.64885251978092	0.277814	0	0.606482379717542	0.277331	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0043195,terminal bouton	GO:0106276,biliberdin reductase NAD+ activity;GO:0004074,biliverdin reductase (NAD(P)+) activity;GO:0106277,biliverdin reductase (NADP+) activity;GO:0042602,riboflavin reductase (NADPH) activity	GO:0042167,heme catabolic process	hsa:645,path:hsa00740,Riboflavin metabolism;hsa:645,path:hsa00860,Porphyrin and chlorophyll metabolism
PPBT_HUMAN	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.191714596	0.189359145	0.54957581	0.469599223	0.1905368705	0.5095875165	0.1905368705	0.5095875165	0.373904117213594	0.115252	0	2.67448245141614	0.115564	0	GO:0031225,anchored component of membrane;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0065010,extracellular membrane-bounded organelle;GO:0005576,extracellular region;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0004035,alkaline phosphatase activity;GO:0046872,metal ion binding;GO:0016462,pyrophosphatase activity	GO:0071407,cellular response to organic cyclic compound;GO:0071529,cementum mineralization;GO:0016311,dephosphorylation;GO:0003006,developmental process involved in reproduction;GO:0001958,endochondral ossification;GO:0001649,osteoblast differentiation;GO:0046677,response to antibiotic;GO:0051384,response to glucocorticoid;GO:0032496,response to lipopolysaccharide;GO:0033280,response to vitamin D;GO:0001501,skeletal system development	hsa:249,path:hsa00730,Thiamine metabolism;hsa:249,path:hsa00790,Folate biosynthesis
PDLI5_HUMAN	Q96HC4	PDLIM5	PDZ and LIM domain protein 5	2.125403168	3.140464627	0.575888395	0.533488923	2.6329338975	0.554688659	2.6329338975	0.554688659	4.74668781266718	0.069361	0	0.210673218771912	0.068905	0	GO:0015629,actin cytoskeleton;GO:0005912,adherens junction;GO:0042995,cell projection;GO:0005829,cytosol;GO:0031941,filamentous actin;GO:0016020,membrane;GO:0014069,postsynaptic density;GO:0098793,presynapse;GO:0001725,stress fiber;GO:0030018,Z disc	GO:0003779,actin binding;GO:0042805,actinin binding;GO:0098641,cadherin binding involved in cell-cell adhesion;GO:0046872,metal ion binding;GO:0051371,muscle alpha-actinin binding;GO:0005080,protein kinase C binding;GO:0047485,protein N-terminus binding	GO:0030036,actin cytoskeleton organization;GO:0061049,cell growth involved in cardiac muscle cell development;GO:0007507,heart development;GO:0061061,muscle structure development;GO:0061001,regulation of dendritic spine morphogenesis;GO:0051963,regulation of synapse assembly	
VPS52_HUMAN	Q8N1B4	VPS52	Vacuolar protein sorting-associated protein 52 homolog	0.114943059	0.146685383	0.253590205	0.166232896	0.130814221	0.2099115505	0.130814221	0.2099115505	0.623187340993892	0.337836	0	1.60465390456287	0.338095	0	GO:0005829,cytosol;GO:1990745,EARP complex;GO:0010008,endosome membrane;GO:0000938,GARP complex;GO:0005794,Golgi apparatus;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm;GO:0055037,recycling endosome;GO:0032588,trans-Golgi network membrane	GO:0019905,syntaxin binding	GO:0010668,ectodermal cell differentiation;GO:0048611,embryonic ectodermal digestive tract development;GO:0032456,endocytic recycling;GO:0006896,Golgi to vacuole transport;GO:0007041,lysosomal transport;GO:0015031,protein transport;GO:0042147,retrograde transport, endosome to Golgi	
PPIF_HUMAN	P30405	PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	3.513652325	1.432347908	0.425669186	0.019567485	2.4730001165	0.2226183355	2.4730001165	0.2226183355	11.108699159688	0.014002	1	0.0900195410484122	0.013823	-1	GO:0005737,cytoplasm;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0005757,mitochondrial permeability transition pore complex;GO:0005739,mitochondrion	GO:0016018,cyclosporin A binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity	GO:0008637,apoptotic mitochondrial changes;GO:0071243,cellular response to arsenic-containing substance;GO:0071277,cellular response to calcium ion;GO:0070301,cellular response to hydrogen peroxide;GO:1902686,mitochondrial outer membrane permeabilization involved in programmed cell death;GO:0070266,necroptotic process;GO:0043066,negative regulation of apoptotic process;GO:0032780,negative regulation of ATPase activity;GO:2001243,negative regulation of intrinsic apoptotic signaling pathway;GO:0090324,negative regulation of oxidative phosphorylation;GO:2000276,negative regulation of oxidative phosphorylation uncoupler activity;GO:0090201,negative regulation of release of cytochrome c from mitochondria;GO:0090200,positive regulation of release of cytochrome c from mitochondria;GO:0006457,protein folding;GO:0000413,protein peptidyl-prolyl isomerization;GO:0046902,regulation of mitochondrial membrane permeability;GO:1902445,regulation of mitochondrial membrane permeability involved in programmed necrotic cell death;GO:0010939,regulation of necrotic cell death;GO:0010849,regulation of proton-transporting ATPase activity, rotational mechanism;GO:0002931,response to ischemia	hsa:10105,path:hsa04020,Calcium signaling pathway;hsa:10105,path:hsa04022,cGMP-PKG signaling pathway;hsa:10105,path:hsa05012,Parkinson disease;hsa:10105,path:hsa05016,Huntington disease;hsa:10105,path:hsa05145,Toxoplasmosis
SAR1A_HUMAN	Q9NR31	SAR1A	GTP-binding protein SAR1a	5.802526221	18.98213852	2.132693035	0.983966407	12.3923323705	1.558329721	12.3923323705	1.558329721	7.9523172814465	0.027715	1	0.125749509810567	0.027435	-1	GO:0030127,COPII vesicle coat;GO:0070971,endoplasmic reticulum exit site;GO:0005794,Golgi apparatus	GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0090110,COPII-coated vesicle cargo loading;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0061024,membrane organization;GO:0070863,positive regulation of protein exit from endoplasmic reticulum;GO:0003400,regulation of COPII vesicle coating;GO:0016050,vesicle organization;GO:0016192,vesicle-mediated transport	hsa:56681,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:56681,path:hsa05134,Legionellosis
DCUP_HUMAN	P06132	UROD	Uroporphyrinogen decarboxylase	0.260828273	0.245480148	0.398716941	0.315259537	0.2531542105	0.356988239	0.2531542105	0.356988239	0.709138797426881	0.412576	0	1.41016117525725	0.412763	0	GO:0005829,cytosol;GO:0005654,nucleoplasm	GO:0004853,uroporphyrinogen decarboxylase activity	GO:0006783,heme biosynthetic process;GO:0006782,protoporphyrinogen IX biosynthetic process;GO:0006779,porphyrin-containing compound biosynthetic process	hsa:7389,path:hsa00860,Porphyrin and chlorophyll metabolism
AGRIN_HUMAN	O00468	AGRN	Agrin	1.191644871	0.567564937	1.395157303	7.137153815	0.879604904	4.266155559	0.879604904	4.266155559	0.20618209810572	0.017485	-1	4.85008159868104	0.017599	1	GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005796,Golgi lumen;GO:0016021,integral component of membrane;GO:0043202,lysosomal lumen;GO:0005886,plasma membrane;GO:0045202,synapse	GO:0005509,calcium ion binding;GO:0035374,chondroitin sulfate binding;GO:0002162,dystroglycan binding;GO:0043395,heparan sulfate proteoglycan binding;GO:0043236,laminin binding;GO:0033691,sialic acid binding;GO:0005200,structural constituent of cytoskeleton	GO:0009887,animal organ morphogenesis;GO:0045162,clustering of voltage-gated sodium channels;GO:0030198,extracellular matrix organization;GO:0007213,G protein-coupled acetylcholine receptor signaling pathway;GO:0006024,glycosaminoglycan biosynthetic process;GO:0006027,glycosaminoglycan catabolic process;GO:0007528,neuromuscular junction development;GO:0051491,positive regulation of filopodium assembly;GO:0043547,positive regulation of GTPase activity;GO:0045887,positive regulation of synaptic growth at neuromuscular junction;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0043113,receptor clustering;GO:0001523,retinoid metabolic process;GO:0007165,signal transduction;GO:0050808,synapse organization;GO:0009888,tissue development;GO:0030154,cell differentiation	hsa:375790,path:hsa04512,ECM-receptor interaction
NDUAB_HUMAN	Q86Y39	NDUFA11	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	0.534613485	0.469396554	0.77015715	0.447451174	0.5020050195	0.608804162	0.5020050195	0.608804162	0.824575538135037	0.497897	0	1.21274516857694	0.497842	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion		GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly	hsa:126328,path:hsa00190,Oxidative phosphorylation;hsa:126328,path:hsa04723,Retrograde endocannabinoid signaling;hsa:126328,path:hsa04714,Thermogenesis;hsa:126328,path:hsa05010,Alzheimer disease;hsa:126328,path:hsa05012,Parkinson disease;hsa:126328,path:hsa05016,Huntington disease;hsa:126328,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
FABPH_HUMAN	P05413	FABP3	Fatty acid-binding protein, heart	0.91772202	11.07645595	0.868718295	1.230188836	5.997088985	1.0494535655	5.997088985	1.0494535655	5.71448721710975	0.050819	0	0.174993829193615	0.050425	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0016528,sarcoplasm	GO:0008092,cytoskeletal protein binding;GO:0050543,icosatetraenoic acid binding;GO:0036041,long-chain fatty acid binding;GO:0005324,long-chain fatty acid transporter activity;GO:0070538,oleic acid binding;GO:0008289,lipid binding	GO:0050873,brown fat cell differentiation;GO:0042632,cholesterol homeostasis;GO:0006631,fatty acid metabolic process;GO:0032365,intracellular lipid transport;GO:0015909,long-chain fatty acid transport;GO:0008285,negative regulation of cell population proliferation;GO:0055091,phospholipid homeostasis;GO:0140214,positive regulation of long-chain fatty acid import into cell;GO:0071073,positive regulation of phospholipid biosynthetic process;GO:0046320,regulation of fatty acid oxidation;GO:2001245,regulation of phosphatidylcholine biosynthetic process;GO:0042493,response to drug;GO:0070542,response to fatty acid;GO:0032868,response to insulin;GO:0019433,triglyceride catabolic process	hsa:2170,path:hsa03320,PPAR signaling pathway
DNJC3_HUMAN	Q13217	DNAJC3	DnaJ homolog subfamily C member 3	9.75367378	5.367025185	8.772921632	26.63110562	7.5603494825	17.702013626	7.5603494825	17.702013626	0.427089801320437	0.159670	0	2.34142795474931	0.160003	0	GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1903561,extracellular vesicle;GO:0016020,membrane;GO:0005790,smooth endoplasmic reticulum	GO:0051087,chaperone binding;GO:0051787,misfolded protein binding;GO:0019901,protein kinase binding;GO:0004860,protein kinase inhibitor activity	GO:0044267,cellular protein metabolic process;GO:0070417,cellular response to cold;GO:0051607,defense response to virus;GO:0036498,IRE1-mediated unfolded protein response;GO:0043066,negative regulation of apoptotic process;GO:1903912,negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;GO:0043312,neutrophil degranulation;GO:0036494,positive regulation of translation initiation in response to endoplasmic reticulum stress;GO:0043687,post-translational protein modification;GO:0034975,protein folding in endoplasmic reticulum;GO:0051603,proteolysis involved in cellular protein catabolic process	hsa:5611,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:5611,path:hsa05164,Influenza A
LV327_HUMAN	P01718	IGLV3-27	Immunoglobulin lambda variable 3-27	0.754258059	1.246529701	0.406333569	0.28550788	1.00039388	0.3459207245	1.00039388	0.3459207245	2.89197440091509	0.143910	0	0.345784526890548	0.143344	0	GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0070062,extracellular exosome;GO:0072562,blood microparticle	GO:0003823,antigen binding	GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
WNT11_HUMAN	O96014	WNT11	Protein Wnt-11	2.55E-05	0.078990996	0.067411874	0.318105587	0.039508248	0.1927587305	0.039508248	0.1927587305	0.204962171609654	0.017097	-1	4.87894908678309	0.017210	1	GO:0005737,cytoplasm;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0005125,cytokine activity;GO:0005109,frizzled binding;GO:0005096,GTPase activator activity;GO:0030295,protein kinase activator activity;GO:0005102,signaling receptor binding	GO:0030325,adrenal gland development;GO:0048844,artery morphogenesis;GO:0003283,atrial septum development;GO:0070830,bicellular tight junction assembly;GO:0030282,bone mineralization;GO:0060070,canonical Wnt signaling pathway;GO:0045165,cell fate commitment;GO:0071260,cellular response to mechanical stimulus;GO:0071300,cellular response to retinoic acid;GO:0060197,cloacal septation;GO:0060028,convergent extension involved in axis elongation;GO:0048706,embryonic skeletal system development;GO:0001837,epithelial to mesenchymal transition;GO:0060484,lung-associated mesenchyme development;GO:0045199,maintenance of epithelial cell apical/basal polarity;GO:0072177,mesonephric duct development;GO:0043066,negative regulation of apoptotic process;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0061037,negative regulation of cartilage development;GO:0060548,negative regulation of cell death;GO:0030308,negative regulation of cell growth;GO:0030336,negative regulation of cell migration;GO:0090272,negative regulation of fibroblast growth factor production;GO:0072201,negative regulation of mesenchymal cell proliferation;GO:0045892,negative regulation of transcription, DNA-templated;GO:0061101,neuroendocrine cell differentiation;GO:0030182,neuron differentiation;GO:0048570,notochord morphogenesis;GO:0001649,osteoblast differentiation;GO:0003151,outflow tract morphogenesis;GO:0048341,paraxial mesoderm formation;GO:0003402,planar cell polarity pathway involved in axis elongation;GO:0060775,planar cell polarity pathway involved in gastrula mediolateral intercalation;GO:0043065,positive regulation of apoptotic process;GO:0030335,positive regulation of cell migration;GO:0010628,positive regulation of gene expression;GO:0043547,positive regulation of GTPase activity;GO:0090082,positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway;GO:0090037,positive regulation of protein kinase C signaling;GO:0051496,positive regulation of stress fiber assembly;GO:0045893,positive regulation of transcription, DNA-templated;GO:0032915,positive regulation of transforming growth factor beta2 production;GO:0003138,primary heart field specification;GO:0034394,protein localization to cell surface;GO:0006468,protein phosphorylation;GO:0031667,response to nutrient levels;GO:0003139,secondary heart field specification;GO:0062009,secondary palate development;GO:0061053,somite development;GO:0060675,ureteric bud morphogenesis;GO:0060412,ventricular septum morphogenesis;GO:0016055,Wnt signaling pathway;GO:0007223,Wnt signaling pathway, calcium modulating pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0007275,multicellular organism development	hsa:7481,path:hsa04310,Wnt signaling pathway;hsa:7481,path:hsa04390,Hippo signaling pathway;hsa:7481,path:hsa04150,mTOR signaling pathway;hsa:7481,path:hsa04550,Signaling pathways regulating pluripotency of stem cells;hsa:7481,path:hsa04916,Melanogenesis;hsa:7481,path:hsa05200,Pathways in cancer;hsa:7481,path:hsa05205,Proteoglycans in cancer;hsa:7481,path:hsa05225,Hepatocellular carcinoma;hsa:7481,path:hsa05226,Gastric cancer;hsa:7481,path:hsa05217,Basal cell carcinoma;hsa:7481,path:hsa05224,Breast cancer;hsa:7481,path:hsa04934,Cushing syndrome;hsa:7481,path:hsa05165,Human papillomavirus infection
CH3L1_HUMAN	P36222	CHI3L1	Chitinase-3-like protein 1	0.15521143	1.24236236	0.328614445	0.128620778	0.698786895	0.2286176115	0.698786895	0.2286176115	3.05657508367416	0.133591	0	0.327163564651567	0.133031	0	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0048471,perinuclear region of cytoplasm;GO:0035580,specific granule lumen	GO:0030246,carbohydrate binding;GO:0008061,chitin binding;GO:0005201,extracellular matrix structural constituent	GO:0007250,activation of NF-kappaB-inducing kinase activity;GO:0006915,apoptotic process;GO:0005975,carbohydrate metabolic process;GO:0051216,cartilage development;GO:0071347,cellular response to interleukin-1;GO:0071356,cellular response to tumor necrosis factor;GO:0006032,chitin catabolic process;GO:0006954,inflammatory response;GO:0030324,lung development;GO:0043312,neutrophil degranulation;GO:0045766,positive regulation of angiogenesis;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0032757,positive regulation of interleukin-8 production;GO:0010800,positive regulation of peptidyl-threonine phosphorylation;GO:0051897,positive regulation of protein kinase B signaling;GO:0070555,response to interleukin-1;GO:0070741,response to interleukin-6;GO:0009612,response to mechanical stimulus;GO:0034612,response to tumor necrosis factor	
AL3A2_HUMAN	P51648	ALDH3A2	Aldehyde dehydrogenase family 3 member A2	1.653247579	2.285186396	4.350187859	4.457719824	1.9692169875	4.4039538415	1.9692169875	4.4039538415	0.447147508437391	0.177306	0	2.23639846164998	0.177642	0	GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005778,peroxisomal membrane;GO:0005777,peroxisome	GO:0004028,3-chloroallyl aldehyde dehydrogenase activity;GO:0004029,aldehyde dehydrogenase (NAD+) activity;GO:0043878,glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity;GO:0046577,long-chain-alcohol oxidase activity;GO:0050061,long-chain-aldehyde dehydrogenase activity;GO:0052814,medium-chain-aldehyde dehydrogenase activity;GO:0042803,protein homodimerization activity;GO:0016620,oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0016491,oxidoreductase activity	GO:0006081,cellular aldehyde metabolic process;GO:0007417,central nervous system development;GO:0008544,epidermis development;GO:0001561,fatty acid alpha-oxidation;GO:0046458,hexadecanal metabolic process;GO:0007422,peripheral nervous system development;GO:0033306,phytol metabolic process;GO:0045046,protein import into peroxisome membrane;GO:0045048,protein insertion into ER membrane;GO:0006714,sesquiterpenoid metabolic process;GO:0030148,sphingolipid biosynthetic process	hsa:224,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:224,path:hsa00053,Ascorbate and aldarate metabolism;hsa:224,path:hsa00620,Pyruvate metabolism;hsa:224,path:hsa00071,Fatty acid degradation;hsa:224,path:hsa00561,Glycerolipid metabolism;hsa:224,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:224,path:hsa00310,Lysine degradation;hsa:224,path:hsa00330,Arginine and proline metabolism;hsa:224,path:hsa00340,Histidine metabolism;hsa:224,path:hsa00380,Tryptophan metabolism;hsa:224,path:hsa00410,beta-Alanine metabolism
ITA2_HUMAN	P17301	ITGA2	Integrin alpha-2	0.636780423	0.514002891	0.942390027	1.456031746	0.575391657	1.1992108865	0.575391657	1.1992108865	0.479808567014706	0.206695	0	2.08416453716499	0.207028	0	GO:0043679,axon terminus;GO:0045178,basal part of cell;GO:0009986,cell surface;GO:0009897,external side of plasma membrane;GO:0005925,focal adhesion;GO:0034666,integrin alpha2-beta1 complex;GO:0008305,integrin complex;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane	GO:0001540,amyloid-beta binding;GO:0005518,collagen binding;GO:0098639,collagen binding involved in cell-matrix adhesion;GO:0038064,collagen receptor activity;GO:0043395,heparan sulfate proteoglycan binding;GO:0005178,integrin binding;GO:0043236,laminin binding;GO:0046872,metal ion binding;GO:0044877,protein-containing complex binding;GO:0001618,virus receptor activity	GO:0009887,animal organ morphogenesis;GO:0007596,blood coagulation;GO:0007155,cell adhesion;GO:0033627,cell adhesion mediated by integrin;GO:0008283,cell population proliferation;GO:0007160,cell-matrix adhesion;GO:0031589,cell-substrate adhesion;GO:0071392,cellular response to estradiol stimulus;GO:0071260,cellular response to mechanical stimulus;GO:0038065,collagen-activated signaling pathway;GO:0050966,detection of mechanical stimulus involved in sensory perception of pain;GO:0045184,establishment of protein localization;GO:0030198,extracellular matrix organization;GO:0007565,female pregnancy;GO:0048041,focal adhesion assembly;GO:0070365,hepatocyte differentiation;GO:0006971,hypotonic response;GO:0007229,integrin-mediated signaling pathway;GO:0030879,mammary gland development;GO:0048333,mesodermal cell differentiation;GO:0010694,positive regulation of alkaline phosphatase activity;GO:0045785,positive regulation of cell adhesion;GO:0031346,positive regulation of cell projection organization;GO:0033343,positive regulation of collagen binding;GO:0032967,positive regulation of collagen biosynthetic process;GO:0043388,positive regulation of DNA binding;GO:0010634,positive regulation of epithelial cell migration;GO:0050729,positive regulation of inflammatory response;GO:0002687,positive regulation of leukocyte migration;GO:0060100,positive regulation of phagocytosis, engulfment;GO:0050927,positive regulation of positive chemotaxis;GO:0014911,positive regulation of smooth muscle cell migration;GO:0048661,positive regulation of smooth muscle cell proliferation;GO:0045987,positive regulation of smooth muscle contraction;GO:0045727,positive regulation of translation;GO:0051971,positive regulation of transmission of nerve impulse;GO:0014075,response to amine;GO:0042493,response to drug;GO:0001666,response to hypoxia;GO:0033591,response to L-ascorbic acid;GO:0014850,response to muscle activity;GO:0071107,response to parathyroid hormone;GO:0043589,skin morphogenesis;GO:0006929,substrate-dependent cell migration	hsa:3673,path:hsa04151,PI3K-Akt signaling pathway;hsa:3673,path:hsa04512,ECM-receptor interaction;hsa:3673,path:hsa04145,Phagosome;hsa:3673,path:hsa04510,Focal adhesion;hsa:3673,path:hsa04810,Regulation of actin cytoskeleton;hsa:3673,path:hsa04640,Hematopoietic cell lineage;hsa:3673,path:hsa04611,Platelet activation;hsa:3673,path:hsa05200,Pathways in cancer;hsa:3673,path:hsa05205,Proteoglycans in cancer;hsa:3673,path:hsa05222,Small cell lung cancer;hsa:3673,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:3673,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:3673,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:3673,path:hsa05165,Human papillomavirus infection
HMOX1_HUMAN	P09601	HMOX1	Heme oxygenase 1	0.327137127	1.587048842	0.770236649	0.464306735	0.9570929845	0.617271692	0.9570929845	0.617271692	1.55052142663299	0.295454	0	0.644944328290602	0.294996	0	GO:0005901,caveola;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005615,extracellular space;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm	GO:0019899,enzyme binding;GO:0020037,heme binding;GO:0004392,heme oxygenase (decyclizing) activity;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0004630,phospholipase D activity;GO:0042803,protein homodimerization activity;GO:0005198,structural molecule activity	GO:0001525,angiogenesis;GO:0008219,cell death;GO:0006879,cellular iron ion homeostasis;GO:0071243,cellular response to arsenic-containing substance;GO:0071276,cellular response to cadmium ion;GO:0072719,cellular response to cisplatin;GO:0034605,cellular response to heat;GO:0071456,cellular response to hypoxia;GO:0031670,cellular response to nutrient;GO:0019221,cytokine-mediated signaling pathway;GO:0001935,endothelial cell proliferation;GO:0034101,erythrocyte homeostasis;GO:0007588,excretion;GO:0042167,heme catabolic process;GO:0006788,heme oxidation;GO:0035556,intracellular signal transduction;GO:0008630,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0055072,iron ion homeostasis;GO:0097421,liver regeneration;GO:0034383,low-density lipoprotein particle clearance;GO:0043392,negative regulation of DNA binding;GO:0043433,negative regulation of DNA-binding transcription factor activity;GO:1904036,negative regulation of epithelial cell apoptotic process;GO:1902042,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0002686,negative regulation of leukocyte migration;GO:0016242,negative regulation of macroautophagy;GO:0032764,negative regulation of mast cell cytokine production;GO:0043305,negative regulation of mast cell degranulation;GO:0010656,negative regulation of muscle cell apoptotic process;GO:0043524,negative regulation of neuron apoptotic process;GO:0048662,negative regulation of smooth muscle cell proliferation;GO:1904706,negative regulation of vascular associated smooth muscle cell proliferation;GO:0045766,positive regulation of angiogenesis;GO:0043065,positive regulation of apoptotic process;GO:1903589,positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0090050,positive regulation of cell migration involved in sprouting angiogenesis;GO:0032722,positive regulation of chemokine production;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0016239,positive regulation of macroautophagy;GO:0048661,positive regulation of smooth muscle cell proliferation;GO:0045048,protein insertion into ER membrane;GO:0045765,regulation of angiogenesis;GO:0008217,regulation of blood pressure;GO:0051090,regulation of DNA-binding transcription factor activity;GO:0034395,regulation of transcription from RNA polymerase II promoter in response to iron;GO:0043619,regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0042493,response to drug;GO:0043627,response to estrogen;GO:0042542,response to hydrogen peroxide;GO:0035094,response to nicotine;GO:0006979,response to oxidative stress;GO:0007264,small GTPase mediated signal transduction;GO:0014806,smooth muscle hyperplasia;GO:0002246,wound healing involved in inflammatory response	hsa:3162,path:hsa00860,Porphyrin and chlorophyll metabolism;hsa:3162,path:hsa04066,HIF-1 signaling pathway;hsa:3162,path:hsa04216,Ferroptosis;hsa:3162,path:hsa04978,Mineral absorption;hsa:3162,path:hsa05200,Pathways in cancer;hsa:3162,path:hsa05206,MicroRNAs in cancer;hsa:3162,path:hsa05225,Hepatocellular carcinoma;hsa:3162,path:hsa05418,Fluid shear stress and atherosclerosis
OST48_HUMAN	P39656	DDOST	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit	6.673951484	4.915146175	14.71772663	5.991970422	5.7945488295	10.354848526	5.7945488295	10.354848526	0.559597643070342	0.279995	0	1.78699823414785	0.280297	0	GO:0035577,azurophil granule membrane;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0008250,oligosaccharyltransferase complex;GO:0005886,plasma membrane	GO:0008047,enzyme activator activity	GO:0043312,neutrophil degranulation;GO:0006486,protein glycosylation;GO:0006487,protein N-linked glycosylation;GO:0018279,protein N-linked glycosylation via asparagine;GO:0031647,regulation of protein stability;GO:0034097,response to cytokine;GO:0042110,T cell activation;GO:0019082,viral protein processing	hsa:1650,path:hsa00510,N-Glycan biosynthesis;hsa:1650,path:hsa00513,Various types of N-glycan biosynthesis;hsa:1650,path:hsa04141,Protein processing in endoplasmic reticulum
GAPR1_HUMAN	Q9H4G4	GLIPR2	Golgi-associated plant pathogenesis-related protein 1	0.877092939	6.364904022	0.205080505	0.357379241	3.6209984805	0.281229873	3.6209984805	0.281229873	12.8755826750311	0.010126	1	0.0776663880182482	0.009984	-1	GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0000139,Golgi membrane;GO:0005576,extracellular region	GO:0042803,protein homodimerization activity	GO:0010634,positive regulation of epithelial cell migration;GO:0010718,positive regulation of epithelial to mesenchymal transition;GO:0070374,positive regulation of ERK1 and ERK2 cascade	
CPNE3_HUMAN	O75131	CPNE3	Copine-3	3.773855907	3.975079755	4.976941499	7.346922312	3.874467831	6.1619319055	3.874467831	6.1619319055	0.628774853474401	0.342836	0	1.59039439073355	0.343091	0	GO:0035577,azurophil granule membrane;GO:0030054,cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0005544,calcium-dependent phospholipid binding;GO:0048306,calcium-dependent protein binding;GO:0046872,metal ion binding;GO:0004674,protein serine/threonine kinase activity;GO:0030971,receptor tyrosine kinase binding;GO:0003723,RNA binding	GO:0071277,cellular response to calcium ion;GO:0071363,cellular response to growth factor stimulus;GO:0038128,ERBB2 signaling pathway;GO:0046474,glycerophospholipid biosynthetic process;GO:0043312,neutrophil degranulation;GO:0030335,positive regulation of cell migration	
TOR4A_HUMAN	Q9NXH8	TOR4A	Torsin-4A	0.040962339	0.103514091	0.129176577	0.195132386	0.072238215	0.1621544815	0.072238215	0.1621544815	0.445490092729876	0.175835	0	2.24471883060787	0.176171	0	GO:0005788,endoplasmic reticulum lumen;GO:0005576,extracellular region;GO:0016021,integral component of membrane;GO:0005635,nuclear envelope;GO:0031093,platelet alpha granule lumen	GO:0005524,ATP binding;GO:0016887,ATPase activity	GO:0002576,platelet degranulation	
AGRE5_HUMAN	P48960	ADGRE5	Adhesion G protein-coupled receptor E5	2.212168339	6.056622844	2.033956625	3.680286489	4.1343955915	2.857121557	4.1343955915	2.857121557	1.44704924484947	0.315859	0	0.69106148499046	0.315434	0	GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0016021,integral component of membrane	GO:0005509,calcium ion binding;GO:0004930,G protein-coupled receptor activity;GO:0004888,transmembrane signaling receptor activity	GO:0007189,adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007155,cell adhesion;GO:0007166,cell surface receptor signaling pathway;GO:0007267,cell-cell signaling;GO:0007186,G protein-coupled receptor signaling pathway;GO:0006955,immune response;GO:0006954,inflammatory response;GO:0043312,neutrophil degranulation	
RRAS2_HUMAN	P62070	RRAS2	Ras-related protein R-Ras2	0.140637524	0.280208489	0.037273457	0.048320291	0.2104230065	0.042796874	0.2104230065	0.042796874	4.91678449458715	0.065491	0	0.203384956387837	0.065046	0	GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0000139,Golgi membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0001649,osteoblast differentiation;GO:0030335,positive regulation of cell migration;GO:0007265,Ras protein signal transduction;GO:1901214,regulation of neuron death;GO:0007165,signal transduction	hsa:22800,path:hsa04014,Ras signaling pathway;hsa:22800,path:hsa04010,MAPK signaling pathway;hsa:22800,path:hsa04371,Apelin signaling pathway;hsa:22800,path:hsa04072,Phospholipase D signaling pathway;hsa:22800,path:hsa04024,cAMP signaling pathway;hsa:22800,path:hsa04140,Autophagy - animal;hsa:22800,path:hsa04137,Mitophagy - animal;hsa:22800,path:hsa04218,Cellular senescence;hsa:22800,path:hsa04810,Regulation of actin cytoskeleton;hsa:22800,path:hsa04625,C-type lectin receptor signaling pathway;hsa:22800,path:hsa05205,Proteoglycans in cancer
PP2AA_HUMAN	P67775	PPP2CA	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	1.345758471	0.841224105	2.269562129	1.410845498	1.093491288	1.8402038135	1.093491288	1.8402038135	0.594222922470865	0.311675	0	1.68287011857748	0.311955	0	GO:0000775,chromosome, centromeric region;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0045121,membrane raft;GO:0015630,microtubule cytoskeleton;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0000159,protein phosphatase type 2A complex;GO:0000922,spindle pole;GO:0045202,synapse	GO:0050811,GABA receptor binding;GO:0046872,metal ion binding;GO:0004721,phosphoprotein phosphatase activity;GO:0008022,protein C-terminus binding;GO:0046982,protein heterodimerization activity;GO:0106306,protein serine phosphatase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0106307,protein threonine phosphatase activity;GO:0048156,tau protein binding	GO:0006915,apoptotic process;GO:0006672,ceramide metabolic process;GO:0000188,inactivation of MAPK activity;GO:0051321,meiotic cell cycle;GO:0007498,mesoderm development;GO:0007084,mitotic nuclear envelope reassembly;GO:0030308,negative regulation of cell growth;GO:0010719,negative regulation of epithelial to mesenchymal transition;GO:0042532,negative regulation of tyrosine phosphorylation of STAT protein;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0070262,peptidyl-serine dephosphorylation;GO:0035970,peptidyl-threonine dephosphorylation;GO:1904528,positive regulation of microtubule binding;GO:0071902,positive regulation of protein serine/threonine kinase activity;GO:0006470,protein dephosphorylation;GO:0030155,regulation of cell adhesion;GO:0045595,regulation of cell differentiation;GO:0006275,regulation of DNA replication;GO:0040008,regulation of growth;GO:1904526,regulation of microtubule binding;GO:0001932,regulation of protein phosphorylation;GO:0006355,regulation of transcription, DNA-templated;GO:0030111,regulation of Wnt signaling pathway;GO:0010288,response to lead ion;GO:0010033,response to organic substance;GO:0008380,RNA splicing;GO:0019932,second-messenger-mediated signaling	hsa:5515,path:hsa03015,mRNA surveillance pathway;hsa:5515,path:hsa04350,TGF-beta signaling pathway;hsa:5515,path:hsa04390,Hippo signaling pathway;hsa:5515,path:hsa04071,Sphingolipid signaling pathway;hsa:5515,path:hsa04151,PI3K-Akt signaling pathway;hsa:5515,path:hsa04152,AMPK signaling pathway;hsa:5515,path:hsa04140,Autophagy - animal;hsa:5515,path:hsa04136,Autophagy - other;hsa:5515,path:hsa04114,Oocyte meiosis;hsa:5515,path:hsa04530,Tight junction;hsa:5515,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:5515,path:hsa04728,Dopaminergic synapse;hsa:5515,path:hsa04730,Long-term depression;hsa:5515,path:hsa05160,Hepatitis C;hsa:5515,path:hsa05165,Human papillomavirus infection;hsa:5515,path:hsa05142,Chagas disease (American trypanosomiasis)
SCPDL_HUMAN	Q8NBX0	SCCPDH	Saccharopine dehydrogenase-like oxidoreductase	0.883215522	0.822023189	1.557672165	0.875171115	0.8526193555	1.21642164	0.8526193555	1.21642164	0.700924192289114	0.405658	0	1.42668780875454	0.405852	0	GO:0005576,extracellular region;GO:0005811,lipid droplet;GO:0016020,membrane;GO:0030496,midbody;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0031093,platelet alpha granule lumen	GO:0016491,oxidoreductase activity	GO:0009247,glycolipid biosynthetic process;GO:0002576,platelet degranulation	
FUND2_HUMAN	Q9BWH2	FUNDC2	FUN14 domain-containing protein 2	0.554826548	2.32160087	0.048242083	0.053188431	1.438213709	0.050715257	1.438213709	0.050715257	28.3586004306357	0.001408	1	0.0352626711055777	0.001377	-1	GO:0031307,integral component of mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0016021,integral component of membrane		GO:0000422,autophagy of mitochondrion	
FAM3C_HUMAN	Q92520	FAM3C	Protein FAM3C	5.640975064	2.772295852	1.456736168	0.853351107	4.206635458	1.1550436375	4.206635458	1.1550436375	3.64197102293462	0.104328	0	0.274576594295421	0.103798	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005794,Golgi apparatus;GO:0031089,platelet dense granule lumen	GO:0005125,cytokine activity	GO:0007275,multicellular organism development;GO:0045721,negative regulation of gluconeogenesis;GO:0002576,platelet degranulation	
KV105_HUMAN	P01602	IGKV1-5	Immunoglobulin kappa variable 1-5	1.163824658	1.760997281	1.393527824	3.260590738	1.4624109695	2.327059281	1.4624109695	2.327059281	0.628437350711394	0.342535	0	1.59124851326548	0.342790	0	GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0072562,blood microparticle;GO:0070062,extracellular exosome	GO:0003823,antigen binding;GO:0042802,identical protein binding	GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
ENOPH_HUMAN	Q9UHY7	ENOPH1	Enolase-phosphatase E1	0.211005264	0.113493083	0.368514495	0.130370503	0.1622491735	0.249442499	0.1622491735	0.249442499	0.650447193844061	0.362064	0	1.53740381919419	0.362301	0	GO:0005829,cytosol;GO:0005634,nucleus	GO:0043715,2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity;GO:0043716,2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity;GO:0043874,acireductone synthase activity;GO:0000287,magnesium ion binding	GO:0019509,L-methionine salvage from methylthioadenosine;GO:0019284,L-methionine salvage from S-adenosylmethionine	hsa:58478,path:hsa00270,Cysteine and methionine metabolism
QKI_HUMAN	Q96PU8	QKI	Protein quaking	0.108543693	0.07230058	0.076007894	0.112005665	0.0904221365	0.0940067795	0.0904221365	0.0940067795	0.961868250151044	0.446274	0	1.03964342293549	0.446105	0	GO:0005737,cytoplasm;GO:0005634,nucleus;GO:0045202,synapse	GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0017124,SH3 domain binding	GO:0042759,long-chain fatty acid biosynthetic process;GO:0006397,mRNA processing;GO:0051028,mRNA transport;GO:0042692,muscle cell differentiation;GO:0042552,myelination;GO:0010628,positive regulation of gene expression;GO:0048024,regulation of mRNA splicing, via spliceosome;GO:0006417,regulation of translation;GO:0008380,RNA splicing;GO:0007286,spermatid development;GO:0001570,vasculogenesis	
CATH_HUMAN	P09668	CTSH	Pro-cathepsin H	1.314394892	5.191041021	2.780330223	1.697894904	3.2527179565	2.2391125635	3.2527179565	2.2391125635	1.45268174969087	0.314696	0	0.688382021879738	0.314269	0	GO:0097208,alveolar lamellar body;GO:0062023,collagen-containing extracellular matrix;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0043231,intracellular membrane-bounded organelle;GO:0005764,lysosome;GO:0097486,multivesicular body lumen;GO:0034774,secretory granule lumen;GO:1904724,tertiary granule lumen	GO:0004177,aminopeptidase activity;GO:0008656,cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0004197,cysteine-type endopeptidase activity;GO:0008234,cysteine-type peptidase activity;GO:0004175,endopeptidase activity;GO:0030108,HLA-A specific activating MHC class I receptor activity;GO:0008233,peptidase activity;GO:0004252,serine-type endopeptidase activity;GO:0070324,thyroid hormone binding	GO:0002250,adaptive immune response;GO:0019882,antigen processing and presentation;GO:0010815,bradykinin catabolic process;GO:0044267,cellular protein metabolic process;GO:0097067,cellular response to thyroid hormone stimulus;GO:0060448,dichotomous subdivision of terminal units involved in lung branching;GO:0070371,ERK1 and ERK2 cascade;GO:0002764,immune response-regulating signaling pathway;GO:0033619,membrane protein proteolysis;GO:0001656,metanephros development;GO:0043066,negative regulation of apoptotic process;GO:0010813,neuropeptide catabolic process;GO:0043312,neutrophil degranulation;GO:0045766,positive regulation of angiogenesis;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0010634,positive regulation of epithelial cell migration;GO:0010628,positive regulation of gene expression;GO:0010952,positive regulation of peptidase activity;GO:0031648,protein destabilization;GO:0006508,proteolysis;GO:0051603,proteolysis involved in cellular protein catabolic process;GO:0032526,response to retinoic acid;GO:0043129,surfactant homeostasis;GO:0001913,T cell mediated cytotoxicity;GO:0031638,zymogen activation	hsa:1512,path:hsa04142,Lysosome;hsa:1512,path:hsa04210,Apoptosis
MANF_HUMAN	P55145	MANF	Mesencephalic astrocyte-derived neurotrophic factor	5.545458965	3.797125638	0.7416173	0.347859175	4.6712923015	0.5447382375	4.6712923015	0.5447382375	8.57529723438957	0.023904	1	0.116614033620863	0.023650	-1	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0033018,sarcoplasmic reticulum lumen	GO:0008083,growth factor activity;GO:0003723,RNA binding;GO:0120146,sulfatide binding	GO:0071542,dopaminergic neuron differentiation;GO:0031175,neuron projection development;GO:0002576,platelet degranulation;GO:1905897,regulation of response to endoplasmic reticulum stress;GO:0006986,response to unfolded protein	
S61A1_HUMAN	P61619	SEC61A1	Protein transport protein Sec61 subunit alpha isoform 1	5.446948581	6.764874361	4.930614641	3.946389531	6.105911471	4.438502086	6.105911471	4.438502086	1.37566939311787	0.331175	0	0.726918840386181	0.330776	0	GO:0005789,endoplasmic reticulum membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016020,membrane;GO:0005784,Sec61 translocon complex;GO:0016021,integral component of membrane;GO:0005791,rough endoplasmic reticulum	GO:0005262,calcium channel activity;GO:0008320,protein transmembrane transporter activity;GO:0043022,ribosome binding;GO:0005048,signal sequence binding	GO:0006613,cotranslational protein targeting to membrane;GO:0007029,endoplasmic reticulum organization;GO:0006620,posttranslational protein targeting to endoplasmic reticulum membrane;GO:0031204,posttranslational protein targeting to membrane, translocation;GO:0039019,pronephric nephron development;GO:0045047,protein targeting to ER;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006616,SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0015031,protein transport;GO:0034341,response to interferon-gamma	hsa:29927,path:hsa03060,Protein export;hsa:29927,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:29927,path:hsa04145,Phagosome;hsa:29927,path:hsa05110,Vibrio cholerae infection
ROCK2_HUMAN	O75116	ROCK2	Rho-associated protein kinase 2	0.443218042	0.448735529	0.794415409	1.214981605	0.4459767855	1.004698507	0.4459767855	1.004698507	0.443891159778542	0.174418	0	2.2528044949102	0.174753	0	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0005815,microtubule organizing center	GO:0005524,ATP binding;GO:0046872,metal ion binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0072518,Rho-dependent protein serine/threonine kinase activity;GO:0003723,RNA binding;GO:0031267,small GTPase binding;GO:0005198,structural molecule activity;GO:0048156,tau protein binding;GO:0050321,tau-protein kinase activity;GO:0004672,protein kinase activity	GO:0030036,actin cytoskeleton organization;GO:0031032,actomyosin structure organization;GO:0003180,aortic valve morphogenesis;GO:0097746,blood vessel diameter maintenance;GO:1905145,cellular response to acetylcholine;GO:0071394,cellular response to testosterone stimulus;GO:0051298,centrosome duplication;GO:0030866,cortical actin cytoskeleton organization;GO:0048598,embryonic morphogenesis;GO:0048013,ephrin receptor signaling pathway;GO:0001837,epithelial to mesenchymal transition;GO:0007186,G protein-coupled receptor signaling pathway;GO:0007249,I-kappaB kinase/NF-kappaB signaling;GO:0000281,mitotic cytokinesis;GO:0061157,mRNA destabilization;GO:0016525,negative regulation of angiogenesis;GO:1903347,negative regulation of bicellular tight junction assembly;GO:0070168,negative regulation of biomineral tissue development;GO:0010629,negative regulation of gene expression;GO:0035509,negative regulation of myosin-light-chain-phosphatase activity;GO:0045019,negative regulation of nitric oxide biosynthetic process;GO:0150033,negative regulation of protein localization to lysosome;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:1902993,positive regulation of amyloid precursor protein catabolic process;GO:1902004,positive regulation of amyloid-beta formation;GO:1902961,positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:0010613,positive regulation of cardiac muscle hypertrophy;GO:0030335,positive regulation of cell migration;GO:0010825,positive regulation of centrosome duplication;GO:0032723,positive regulation of connective tissue growth factor production;GO:1905205,positive regulation of connective tissue replacement;GO:0010595,positive regulation of endothelial cell migration;GO:0090271,positive regulation of fibroblast growth factor production;GO:0010628,positive regulation of gene expression;GO:0043410,positive regulation of MAPK cascade;GO:1902966,positive regulation of protein localization to early endosome;GO:0001934,positive regulation of protein phosphorylation;GO:0051496,positive regulation of stress fiber assembly;GO:0072659,protein localization to plasma membrane;GO:0006468,protein phosphorylation;GO:0032956,regulation of actin cytoskeleton organization;GO:0110061,regulation of angiotensin-activated signaling pathway;GO:0030155,regulation of cell adhesion;GO:1901888,regulation of cell junction assembly;GO:2000145,regulation of cell motility;GO:1900037,regulation of cellular response to hypoxia;GO:0042752,regulation of circadian rhythm;GO:2000114,regulation of establishment of cell polarity;GO:1903140,regulation of establishment of endothelial barrier;GO:0051893,regulation of focal adhesion assembly;GO:0045616,regulation of keratinocyte differentiation;GO:0031644,regulation of nervous system process;GO:0051246,regulation of protein metabolic process;GO:0051492,regulation of stress fiber assembly;GO:1990776,response to angiotensin;GO:0002931,response to ischemia;GO:0071559,response to transforming growth factor beta;GO:0007266,Rho protein signal transduction;GO:0048511,rhythmic process;GO:0006939,smooth muscle contraction;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:0039694,viral RNA genome replication	hsa:9475,path:hsa04310,Wnt signaling pathway;hsa:9475,path:hsa04071,Sphingolipid signaling pathway;hsa:9475,path:hsa04024,cAMP signaling pathway;hsa:9475,path:hsa04022,cGMP-PKG signaling pathway;hsa:9475,path:hsa04510,Focal adhesion;hsa:9475,path:hsa04530,Tight junction;hsa:9475,path:hsa04810,Regulation of actin cytoskeleton;hsa:9475,path:hsa04611,Platelet activation;hsa:9475,path:hsa04670,Leukocyte transendothelial migration;hsa:9475,path:hsa04062,Chemokine signaling pathway;hsa:9475,path:hsa04921,Oxytocin signaling pathway;hsa:9475,path:hsa04270,Vascular smooth muscle contraction;hsa:9475,path:hsa04360,Axon guidance;hsa:9475,path:hsa05200,Pathways in cancer;hsa:9475,path:hsa05205,Proteoglycans in cancer;hsa:9475,path:hsa05130,Pathogenic Escherichia coli infection;hsa:9475,path:hsa05132,Salmonella infection;hsa:9475,path:hsa05131,Shigellosis;hsa:9475,path:hsa05135,Yersinia infection;hsa:9475,path:hsa05163,Human cytomegalovirus infection
NU155_HUMAN	O75694	NUP155	Nuclear pore complex protein Nup155	1.195865321	0.999896015	1.159281235	8.535609043	1.097880668	4.847445139	1.097880668	4.847445139	0.22648645554893	0.024697	-1	4.41527506612404	0.024841	1	GO:0005829,cytosol;GO:0043657,host cell;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0044611,nuclear pore inner ring;GO:0005643,nuclear pore	GO:0017056,structural constituent of nuclear pore	GO:0086014,atrial cardiac muscle cell action potential;GO:0075733,intracellular transport of virus;GO:0007084,mitotic nuclear envelope reassembly;GO:0006406,mRNA export from nucleus;GO:0006998,nuclear envelope organization;GO:0006606,protein import into nucleus;GO:0036228,protein localization to nuclear inner membrane;GO:0016925,protein sumoylation;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0006405,RNA export from nucleus;GO:0000972,transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription	hsa:9631,path:hsa03013,RNA transport
HMCS1_HUMAN	Q01581	HMGCS1	Hydroxymethylglutaryl-CoA synthase, cytoplasmic	0.16528612	0.061437396	0.232709317	0.117137312	0.113361758	0.1749233145	0.113361758	0.1749233145	0.64806545842121	0.359964	0	1.54305400327331	0.360204	0	GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0004421,hydroxymethylglutaryl-CoA synthase activity;GO:0016853,isomerase activity;GO:0043177,organic acid binding;GO:0042803,protein homodimerization activity;GO:0016746,transferase activity, transferring acyl groups	GO:0006084,acetyl-CoA metabolic process;GO:0007420,brain development;GO:0071397,cellular response to cholesterol;GO:0071372,cellular response to follicle-stimulating hormone stimulus;GO:0071404,cellular response to low-density lipoprotein particle stimulus;GO:0006695,cholesterol biosynthetic process;GO:0010142,farnesyl diphosphate biosynthetic process, mevalonate pathway;GO:0006629,lipid metabolic process;GO:0001889,liver development;GO:0008584,male gonad development;GO:0019216,regulation of lipid metabolic process;GO:0019222,regulation of metabolic process;GO:0042493,response to drug;GO:0009645,response to low light intensity stimulus;GO:0014074,response to purine-containing compound;GO:0046690,response to tellurium ion;GO:0033197,response to vitamin E	hsa:3157,path:hsa00650,Butanoate metabolism;hsa:3157,path:hsa00072,Synthesis and degradation of ketone bodies;hsa:3157,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:3157,path:hsa00900,Terpenoid backbone biosynthesis;hsa:3157,path:hsa03320,PPAR signaling pathway
EIF3M_HUMAN	Q7L2H7	EIF3M	Eukaryotic translation initiation factor 3 subunit M	0.512319271	0.614440071	1.530795283	0.744210949	0.563379671	1.137503116	0.563379671	1.137503116	0.495277474914627	0.220813	0	2.01907021952164	0.221143	0	GO:0005829,cytosol;GO:0016282,eukaryotic 43S preinitiation complex;GO:0033290,eukaryotic 48S preinitiation complex;GO:0005852,eukaryotic translation initiation factor 3 complex;GO:0071541,eukaryotic translation initiation factor 3 complex, eIF3m	GO:0003743,translation initiation factor activity;GO:0031369,translation initiation factor binding	GO:0002183,cytoplasmic translational initiation;GO:0001732,formation of cytoplasmic translation initiation complex;GO:0006413,translational initiation;GO:0016032,viral process	
H1X_HUMAN	Q92522	H1-10	Histone H1.10	3.806972303	3.137991112	0.729717494	0.518030011	3.4724817075	0.6238737525	3.4724817075	0.6238737525	5.56600064289449	0.053180	0	0.179662214246524	0.052777	0	GO:0015629,actin cytoskeleton;GO:0000785,chromatin;GO:0000791,euchromatin;GO:0005794,Golgi apparatus;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0000786,nucleosome;GO:0005634,nucleus;GO:0017053,transcription repressor complex;GO:0000792,heterochromatin;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0001673,male germ cell nucleus;GO:0005730,nucleolus	GO:0031490,chromatin DNA binding;GO:0003690,double-stranded DNA binding;GO:0003680,minor groove of adenine-thymine-rich DNA binding;GO:0031492,nucleosomal DNA binding;GO:0003723,RNA binding;GO:0005524,ATP binding;GO:0003677,DNA binding;GO:0043531,ADP binding;GO:0016208,AMP binding;GO:0005509,calcium ion binding;GO:0032564,dATP binding;GO:0005525,GTP binding;GO:0042826,histone deacetylase binding;GO:0042393,histone binding;GO:0003676,nucleic acid binding;GO:0045296,cadherin binding	GO:0006309,apoptotic DNA fragmentation;GO:0006342,chromatin silencing;GO:0030261,chromosome condensation;GO:0031936,negative regulation of chromatin silencing;GO:0045910,negative regulation of DNA recombination;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0006334,nucleosome assembly;GO:0016584,nucleosome positioning;GO:2000679,positive regulation of transcription regulatory region DNA binding;GO:0007275,multicellular organism development;GO:0035092,sperm chromatin condensation;GO:0007290,spermatid nucleus elongation;GO:0006325,chromatin organization;GO:0071169,establishment of protein localization to chromatin;GO:0030307,positive regulation of cell growth;GO:0051574,positive regulation of histone H3-K9 methylation;GO:0050821,protein stabilization;GO:0051321,meiotic cell cycle;GO:2000737,negative regulation of stem cell differentiation;GO:0044030,regulation of DNA methylation;GO:0006338,chromatin remodeling;GO:0007281,germ cell development;GO:0006355,regulation of transcription, DNA-templated;GO:0007283,spermatogenesis;GO:0030154,cell differentiation	
PSA2_HUMAN	P25787	PSMA2	Proteasome subunit alpha type-2	0.204785038	3.480985521	2.740700437	1.309165376	1.8428852795	2.0249329065	1.8428852795	2.0249329065	0.910096958563106	0.464761	0	1.09878402580186	0.464632	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body;GO:0000502,proteasome complex;GO:0005839,proteasome core complex;GO:0019773,proteasome core complex, alpha-subunit complex;GO:0034774,secretory granule lumen	GO:0004175,endopeptidase activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0043312,neutrophil degranulation;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0009615,response to virus;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0051603,proteolysis involved in cellular protein catabolic process	hsa:5683,path:hsa03050,Proteasome
CLPB_HUMAN	Q9H078	CLPB	Caseinolytic peptidase B protein homolog	0.177284565	0.062287211	0.224983637	0.079726696	0.119785888	0.1523551665	0.119785888	0.1523551665	0.786227935368375	0.474796	0	1.27189578875936	0.474916	0	GO:0005737,cytoplasm;GO:0005758,mitochondrial intermembrane space;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0016887,ATPase activity	GO:0140374,antiviral innate immune response;GO:0034605,cellular response to heat;GO:0039529,RIG-I signaling pathway	hsa:81570,path:hsa04213,Longevity regulating pathway - multiple species
M4K4_HUMAN	O95819	MAP4K4	Mitogen-activated protein kinase kinase kinase kinase 4	0.084071955	0.123213093	0.111487202	0.159292082	0.103642524	0.135389642	0.103642524	0.135389642	0.765512948176641	0.458576	0	1.3063136324237	0.458713	0	GO:0005737,cytoplasm;GO:0005925,focal adhesion	GO:0005524,ATP binding;GO:0004111,creatine kinase activity;GO:0008017,microtubule binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0004672,protein kinase activity	GO:0032147,activation of protein kinase activity;GO:0035556,intracellular signal transduction;GO:0000165,MAPK cascade;GO:0043066,negative regulation of apoptotic process;GO:0001953,negative regulation of cell-matrix adhesion;GO:0048812,neuron projection morphogenesis;GO:0032014,positive regulation of ARF protein signal transduction;GO:0030335,positive regulation of cell migration;GO:0051894,positive regulation of focal adhesion assembly;GO:0120183,positive regulation of focal adhesion disassembly;GO:0043547,positive regulation of GTPase activity;GO:0051549,positive regulation of keratinocyte migration;GO:0006468,protein phosphorylation;GO:0046328,regulation of JNK cascade;GO:0031098,stress-activated protein kinase signaling cascade;GO:0061179,negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0070571,negative regulation of neuron projection regeneration	hsa:9448,path:hsa04010,MAPK signaling pathway
SNF5_HUMAN	Q12824	SMARCB1	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	2.214712305	0.25529123	1.050989289	0.855372402	1.2350017675	0.9531808455	1.2350017675	0.9531808455	1.29566364382004	0.349686	0	0.771805248043906	0.349320	0	GO:0035060,brahma complex;GO:0000785,chromatin;GO:0001650,fibrillar center;GO:0043231,intracellular membrane-bounded organelle;GO:0071565,nBAF complex;GO:0071564,npBAF complex;GO:0000228,nuclear chromosome;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0016514,SWI/SNF complex;GO:0001741,XY body	GO:0003677,DNA binding;GO:0002039,p53 binding;GO:0030957,Tat protein binding;GO:0003713,transcription coactivator activity;GO:0003712,transcription coregulator activity	GO:0043044,ATP-dependent chromatin remodeling;GO:0007049,cell cycle;GO:0006338,chromatin remodeling;GO:0015074,DNA integration;GO:1900110,negative regulation of histone H3-K9 dimethylation;GO:1900113,negative regulation of histone H3-K9 trimethylation;GO:0007399,nervous system development;GO:0006337,nucleosome disassembly;GO:0043923,positive regulation by host of viral transcription;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:1902661,positive regulation of glucose mediated signaling pathway;GO:2000617,positive regulation of histone H3-K9 acetylation;GO:0090240,positive regulation of histone H4 acetylation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:1901838,positive regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0006357,regulation of transcription by RNA polymerase II;GO:0001188,RNA polymerase I preinitiation complex assembly;GO:0039692,single stranded viral RNA replication via double stranded DNA intermediate;GO:0001835,blastocyst hatching;GO:0030154,cell differentiation;GO:0008285,negative regulation of cell population proliferation	hsa:6598,path:hsa04714,Thermogenesis;hsa:6598,path:hsa05225,Hepatocellular carcinoma
SGTA_HUMAN	O43765	SGTA	Small glutamine-rich tetratricopeptide repeat-containing protein alpha	0.148747878	0.050031438	0.751076914	2.55E-05	0.099389658	0.375551207	0.099389658	0.375551207	0.264650082724937	0.042066	-1	3.77857429592926	0.042265	1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005634,nucleus;GO:0072380,TRC complex	GO:1904288,BAT3 complex binding;GO:0042802,identical protein binding;GO:0060090,molecular adaptor activity;GO:0043621,protein self-association	GO:1903070,negative regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:2000059,negative regulation of ubiquitin-dependent protein catabolic process;GO:1903646,positive regulation of chaperone-mediated protein folding;GO:1903071,positive regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:0006620,posttranslational protein targeting to endoplasmic reticulum membrane;GO:0045048,protein insertion into ER membrane;GO:0071816,tail-anchored membrane protein insertion into ER membrane;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0016032,viral process	
TMED2_HUMAN	Q15363	TMED2	Transmembrane emp24 domain-containing protein 2	3.405838817	3.015622347	0.254449418	2.55E-05	3.210730582	0.127237459	3.210730582	0.127237459	25.2341614429757	0.001934	1	0.0396288183484839	0.001894	-1	GO:0030137,COPI-coated vesicle;GO:0030663,COPI-coated vesicle membrane;GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0005794,Golgi apparatus;GO:0032580,Golgi cisterna membrane;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0030133,transport vesicle;GO:0042589,zymogen granule membrane		GO:0048205,COPI coating of Golgi vesicle;GO:0048208,COPII vesicle coating;GO:0090158,endoplasmic reticulum membrane organization;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030,Golgi organization;GO:0001947,heart looping;GO:0006886,intracellular protein transport;GO:0060716,labyrinthine layer blood vessel development;GO:0001893,maternal placenta development;GO:0035264,multicellular organism growth;GO:1903912,negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;GO:0034260,negative regulation of GTPase activity;GO:0001843,neural tube closure;GO:0036499,PERK-mediated unfolded protein response;GO:0010628,positive regulation of gene expression;GO:0036342,post-anal tail morphogenesis;GO:0072659,protein localization to plasma membrane;GO:2000638,regulation of SREBP signaling pathway;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0032525,somite rostral/caudal axis specification;GO:0035459,vesicle cargo loading;GO:0015031,protein transport	
COQ8A_HUMAN	Q8NI60	COQ8A	Atypical kinase COQ8A, mitochondrial	0.032485097	0.03542176	0.199271548	0.504262163	0.0339534285	0.3517668555	0.0339534285	0.3517668555	0.0965225346536379	0.000540	-1	10.3602749719369	0.000548	1	GO:0031314,extrinsic component of mitochondrial inner membrane;GO:0016021,integral component of membrane;GO:0005739,mitochondrion	GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0016301,kinase activity	GO:0016310,phosphorylation;GO:0006468,protein phosphorylation;GO:0006744,ubiquinone biosynthetic process	
LS14A_HUMAN	Q8ND56	LSM14A	Protein LSM14 homolog A	0.070245194	2.55E-05	0.010259649	2.55E-05	0.035135347	0.0051425745	0.035135347	0.0051425745	6.83224851676918	0.036925	1	0.14636469934394	0.036594	-1	GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:1990124,messenger ribonucleoprotein complex;GO:0072686,mitotic spindle;GO:0000932,P-body	GO:0003690,double-stranded DNA binding;GO:0003725,double-stranded RNA binding;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0003727,single-stranded RNA binding	GO:0090307,mitotic spindle assembly;GO:0007275,multicellular organism development;GO:0017148,negative regulation of translation;GO:0033962,P-body assembly;GO:0060340,positive regulation of type I interferon-mediated signaling pathway;GO:0039529,RIG-I signaling pathway;GO:0034063,stress granule assembly	
ODPA_HUMAN	P08559	PDHA1	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	2.587308242	2.073200322	3.838914284	1.74544264	2.330254282	2.792178462	2.330254282	2.792178462	0.834564951242719	0.493848	0	1.19822908751552	0.493784	0	GO:0005759,mitochondrial matrix;GO:0005967,mitochondrial pyruvate dehydrogenase complex;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005634,nucleus;GO:0045254,pyruvate dehydrogenase complex	GO:0004739,pyruvate dehydrogenase (acetyl-transferring) activity;GO:0034604,pyruvate dehydrogenase (NAD+) activity;GO:0016624,oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	GO:0006086,acetyl-CoA biosynthetic process from pyruvate;GO:0006006,glucose metabolic process;GO:0061732,mitochondrial acetyl-CoA biosynthetic process from pyruvate;GO:0006090,pyruvate metabolic process;GO:0006099,tricarboxylic acid cycle	hsa:5160,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:5160,path:hsa00020,Citrate cycle (TCA cycle);hsa:5160,path:hsa00620,Pyruvate metabolism;hsa:5160,path:hsa04066,HIF-1 signaling pathway;hsa:5160,path:hsa04922,Glucagon signaling pathway;hsa:5160,path:hsa05230,Central carbon metabolism in cancer
PSMD2_HUMAN	Q13200	PSMD2	26S proteasome non-ATPase regulatory subunit 2	5.820526007	3.814556483	7.040159681	7.752282759	4.817541245	7.39622122	4.817541245	7.39622122	0.651351697265756	0.362860	0	1.53526889420539	0.363097	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0022624,proteasome accessory complex;GO:0000502,proteasome complex;GO:0005838,proteasome regulatory particle;GO:0008540,proteasome regulatory particle, base subcomplex;GO:0034515,proteasome storage granule;GO:0034774,secretory granule lumen	GO:0030234,enzyme regulator activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0043312,neutrophil degranulation;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0042176,regulation of protein catabolic process;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5708,path:hsa03050,Proteasome;hsa:5708,path:hsa05169,Epstein-Barr virus infection
LUC7L_HUMAN	Q9NQ29	LUC7L	Putative RNA-binding protein Luc7-like 1	0.068379557	0.038088041	0.082279756	2.55E-05	0.053233799	0.041152628	0.053233799	0.041152628	1.29356985415366	0.350190	0	0.773054502459988	0.349826	0	GO:0005685,U1 snRNP;GO:0071004,U2-type prespliceosome	GO:0042802,identical protein binding;GO:0003729,mRNA binding	GO:0006376,mRNA splice site selection	
NU4M_HUMAN	P03905	MT-ND4	NADH-ubiquinone oxidoreductase chain 4	0.211696758	0.171413494	0.453310098	0.22307783	0.191555126	0.338193964	0.191555126	0.338193964	0.566406105343737	0.286250	0	1.76551769228039	0.286548	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0005750,mitochondrial respiratory chain complex III;GO:0005751,mitochondrial respiratory chain complex IV;GO:0045277,respiratory chain complex IV;GO:0005739,mitochondrion;GO:0005753,mitochondrial proton-transporting ATP synthase complex;GO:0045263,proton-transporting ATP synthase complex, coupling factor F(o);GO:0000276,mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0031305,integral component of mitochondrial inner membrane;GO:0016020,membrane;GO:0005615,extracellular space;GO:0014069,postsynaptic density;GO:0070469,respirasome;GO:0005576,extracellular region;GO:0048471,perinuclear region of cytoplasm;GO:0030425,dendrite;GO:0031966,mitochondrial membrane;GO:0043025,neuronal cell body;GO:0043005,neuron projection	GO:0008137,NADH dehydrogenase (ubiquinone) activity;GO:0048039,ubiquinone binding;GO:0004129,cytochrome-c oxidase activity;GO:0020037,heme binding;GO:0046872,metal ion binding;GO:0009055,electron transfer activity;GO:0015453,oxidoreduction-driven active transmembrane transporter activity;GO:0015078,proton transmembrane transporter activity;GO:0044877,protein-containing complex binding;GO:0008121,ubiquinol-cytochrome-c reductase activity;GO:0005507,copper ion binding;GO:0035255,ionotropic glutamate receptor binding;GO:0019901,protein kinase binding;GO:0048019,receptor antagonist activity;GO:0005102,signaling receptor binding;GO:0003954,NADH dehydrogenase activity	GO:0009060,aerobic respiration;GO:0007568,aging;GO:0021549,cerebellum development;GO:0015990,electron transport coupled proton transport;GO:0001701,in utero embryonic development;GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0045471,response to ethanol;GO:0001666,response to hypoxia;GO:0035094,response to nicotine;GO:0006123,mitochondrial electron transport, cytochrome c to oxygen;GO:0022904,respiratory electron transport chain;GO:0046688,response to copper ion;GO:0051602,response to electrical stimulus;GO:0006979,response to oxidative stress;GO:0008535,respiratory chain complex IV assembly;GO:0006754,ATP biosynthetic process;GO:0015986,ATP synthesis coupled proton transport;GO:0042407,cristae formation;GO:0042776,mitochondrial ATP synthesis coupled proton transport;GO:0055093,response to hyperoxia;GO:0031100,animal organ regeneration;GO:0042538,hyperosmotic salinity response;GO:0006122,mitochondrial electron transport, ubiquinol to cytochrome c;GO:0046686,response to cadmium ion;GO:0051592,response to calcium ion;GO:0033590,response to cobalamin;GO:0042493,response to drug;GO:0033762,response to glucagon;GO:0009408,response to heat;GO:0046689,response to mercury ion;GO:0009636,response to toxic substance;GO:0042773,ATP synthesis coupled electron transport;GO:0007595,lactation;GO:2001171,positive regulation of ATP biosynthetic process;GO:0010729,positive regulation of hydrogen peroxide biosynthetic process;GO:0010940,positive regulation of necrotic cell death;GO:0009409,response to cold;GO:0032147,activation of protein kinase activity;GO:0072522,purine-containing compound biosynthetic process;GO:0043610,regulation of carbohydrate utilization;GO:0072593,reactive oxygen species metabolic process;GO:0042220,response to cocaine;GO:0042542,response to hydrogen peroxide;GO:0006915,apoptotic process;GO:0006879,cellular iron ion homeostasis;GO:0007186,G protein-coupled receptor signaling pathway;GO:0030595,leukocyte chemotaxis;GO:0043066,negative regulation of apoptotic process;GO:1900118,negative regulation of execution phase of apoptosis;GO:0033194,response to hydroperoxide;GO:0014070,response to organic cyclic compound;GO:0071385,cellular response to glucocorticoid stimulus;GO:0009642,response to light intensity;GO:0010243,response to organonitrogen compound	hsa:4538,path:hsa00190,Oxidative phosphorylation;hsa:4538,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4538,path:hsa04714,Thermogenesis;hsa:4538,path:hsa05012,Parkinson disease;hsa:4512,path:hsa00190,Oxidative phosphorylation;hsa:4512,path:hsa04260,Cardiac muscle contraction;hsa:4512,path:hsa04714,Thermogenesis;hsa:4512,path:hsa05010,Alzheimer disease;hsa:4512,path:hsa05012,Parkinson disease;hsa:4512,path:hsa05016,Huntington disease;hsa:4512,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4514,path:hsa00190,Oxidative phosphorylation;hsa:4514,path:hsa04260,Cardiac muscle contraction;hsa:4514,path:hsa04714,Thermogenesis;hsa:4514,path:hsa05010,Alzheimer disease;hsa:4514,path:hsa05012,Parkinson disease;hsa:4514,path:hsa05016,Huntington disease;hsa:4514,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4508,path:hsa00190,Oxidative phosphorylation;hsa:4508,path:hsa04714,Thermogenesis;hsa:4508,path:hsa05010,Alzheimer disease;hsa:4508,path:hsa05012,Parkinson disease;hsa:4508,path:hsa05016,Huntington disease;hsa:4509,path:hsa00190,Oxidative phosphorylation;hsa:4509,path:hsa04714,Thermogenesis;hsa:4509,path:hsa05010,Alzheimer disease;hsa:4509,path:hsa05012,Parkinson disease;hsa:4509,path:hsa05016,Huntington disease;hsa:4519,path:hsa00190,Oxidative phosphorylation;hsa:4519,path:hsa04260,Cardiac muscle contraction;hsa:4519,path:hsa04714,Thermogenesis;hsa:4519,path:hsa05010,Alzheimer disease;hsa:4519,path:hsa05012,Parkinson disease;hsa:4519,path:hsa05016,Huntington disease;hsa:4519,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4513,path:hsa00190,Oxidative phosphorylation;hsa:4513,path:hsa04260,Cardiac muscle contraction;hsa:4513,path:hsa04714,Thermogenesis;hsa:4513,path:hsa05010,Alzheimer disease;hsa:4513,path:hsa05012,Parkinson disease;hsa:4513,path:hsa05016,Huntington disease;hsa:4513,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4536,path:hsa00190,Oxidative phosphorylation;hsa:4536,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4536,path:hsa04714,Thermogenesis;hsa:4536,path:hsa05012,Parkinson disease;hsa:4541,path:hsa00190,Oxidative phosphorylation;hsa:4541,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4541,path:hsa04714,Thermogenesis;hsa:4541,path:hsa05012,Parkinson disease;hsa:4539,path:hsa00190,Oxidative phosphorylation;hsa:4539,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4539,path:hsa04714,Thermogenesis;hsa:4539,path:hsa05012,Parkinson disease;hsa:4535,path:hsa00190,Oxidative phosphorylation;hsa:4535,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4535,path:hsa04714,Thermogenesis;hsa:4535,path:hsa05012,Parkinson disease;hsa:4537,path:hsa00190,Oxidative phosphorylation;hsa:4537,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4537,path:hsa04714,Thermogenesis;hsa:4537,path:hsa05012,Parkinson disease;hsa:4540,path:hsa00190,Oxidative phosphorylation;hsa:4540,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4540,path:hsa04714,Thermogenesis;hsa:4540,path:hsa05012,Parkinson disease
TYPH_HUMAN	P19971	TYMP	Thymidine phosphorylase	33.62777954	33.69070881	37.4367401	15.86626609	33.659244175	26.651503095	33.659244175	26.651503095	1.26293980699778	0.357702	0	0.791803373730985	0.357351	0	GO:0005829,cytosol	GO:0004645,1,4-alpha-oligoglucan phosphorylase activity;GO:0008083,growth factor activity;GO:0042803,protein homodimerization activity;GO:0016154,pyrimidine-nucleoside phosphorylase activity;GO:0009032,thymidine phosphorylase activity;GO:0016763,transferase activity, transferring pentosyl groups	GO:0001525,angiogenesis;GO:0030154,cell differentiation;GO:0006935,chemotaxis;GO:0046074,dTMP catabolic process;GO:0000002,mitochondrial genome maintenance;GO:0006206,pyrimidine nucleobase metabolic process;GO:0046135,pyrimidine nucleoside catabolic process;GO:0006213,pyrimidine nucleoside metabolic process;GO:0043097,pyrimidine nucleoside salvage;GO:1905333,regulation of gastric motility;GO:0031641,regulation of myelination;GO:0051969,regulation of transmission of nerve impulse	hsa:1890,path:hsa00240,Pyrimidine metabolism;hsa:1890,path:hsa00983,Drug metabolism - other enzymes;hsa:1890,path:hsa05219,Bladder cancer
SRC8_HUMAN	Q14247	CTTN	Src substrate cortactin	2.171314616	2.318255466	1.521720638	1.235492924	2.244785041	1.378606781	2.244785041	1.378606781	1.62829972399505	0.281370	0	0.614137548059329	0.280892	0	GO:0005938,cell cortex;GO:0005905,clathrin-coated pit;GO:0030864,cortical actin cytoskeleton;GO:0030863,cortical cytoskeleton;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0030027,lamellipodium;GO:1990023,mitotic spindle midzone;GO:0005886,plasma membrane;GO:0002102,podosome;GO:0001726,ruffle;GO:0030427,site of polarized growth;GO:0008076,voltage-gated potassium channel complex	GO:0051015,actin filament binding;GO:0045296,cadherin binding;GO:0005522,profilin binding	GO:0031532,actin cytoskeleton reorganization;GO:0030041,actin filament polymerization;GO:0048870,cell motility;GO:0097062,dendritic spine maintenance;GO:0048041,focal adhesion assembly;GO:0006886,intracellular protein transport;GO:0097581,lamellipodium organization;GO:0061024,membrane organization;GO:2001237,negative regulation of extrinsic apoptotic signaling pathway;GO:0048812,neuron projection morphogenesis;GO:0030838,positive regulation of actin filament polymerization;GO:0045987,positive regulation of smooth muscle contraction;GO:0006898,receptor-mediated endocytosis;GO:0030833,regulation of actin filament polymerization;GO:1903146,regulation of autophagy of mitochondrion;GO:0030516,regulation of axon extension;GO:0006930,substrate-dependent cell migration, cell extension	hsa:2017,path:hsa04530,Tight junction;hsa:2017,path:hsa05205,Proteoglycans in cancer;hsa:2017,path:hsa05130,Pathogenic Escherichia coli infection;hsa:2017,path:hsa05131,Shigellosis;hsa:2017,path:hsa05100,Bacterial invasion of epithelial cells
SYSC_HUMAN	P49591	SARS1	Serine--tRNA ligase, cytoplasmic	2.876397709	1.801109289	4.157782855	3.204526833	2.338753499	3.681154844	2.338753499	3.681154844	0.635331464747262	0.348682	0	1.57398154426021	0.348931	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0019899,enzyme binding;GO:0042803,protein homodimerization activity;GO:0003723,RNA binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004828,serine-tRNA ligase activity;GO:0000049,tRNA binding	GO:0016525,negative regulation of angiogenesis;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:1904046,negative regulation of vascular endothelial growth factor production;GO:0016259,selenocysteine metabolic process;GO:0097056,selenocysteinyl-tRNA(Sec) biosynthetic process;GO:0006434,seryl-tRNA aminoacylation;GO:0006412,translation;GO:0006418,tRNA aminoacylation for protein translation;GO:0008033,tRNA processing	hsa:6301,path:hsa00970,Aminoacyl-tRNA biosynthesis
ABCD3_HUMAN	P28288	ABCD3	ATP-binding cassette sub-family D member 3	0.717890908	0.797038461	2.143437263	0.959227525	0.7574646845	1.551332394	0.7574646845	1.551332394	0.488267174352578	0.214403	0	2.04805903924621	0.214735	0	GO:0005829,cytosol;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005782,peroxisomal matrix;GO:0005778,peroxisomal membrane;GO:0005777,peroxisome	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0042626,ATPase-coupled transmembrane transporter activity;GO:0005324,long-chain fatty acid transporter activity;GO:0042803,protein homodimerization activity;GO:0043621,protein self-association	GO:0006635,fatty acid beta-oxidation;GO:0006633,fatty acid biosynthetic process;GO:0006869,lipid transport;GO:0015910,long-chain fatty acid import into peroxisome;GO:0007031,peroxisome organization;GO:0045046,protein import into peroxisome membrane;GO:0042493,response to drug;GO:0014070,response to organic cyclic compound;GO:0042760,very long-chain fatty acid catabolic process	hsa:5825,path:hsa02010,ABC transporters;hsa:5825,path:hsa04146,Peroxisome
SC24A_HUMAN	O95486	SEC24A	Protein transport protein Sec24A	0.586242346	0.332022557	1.290675777	0.267754968	0.4591324515	0.7792153725	0.4591324515	0.7792153725	0.589224067829848	0.307125	0	1.69714723922101	0.307408	0	GO:0030127,COPII vesicle coat;GO:0005829,cytosol;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0012507,ER to Golgi transport vesicle membrane	GO:0000149,SNARE binding;GO:0008270,zinc ion binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0048208,COPII vesicle coating;GO:0090110,COPII-coated vesicle cargo loading;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport	hsa:10802,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:10802,path:hsa05130,Pathogenic Escherichia coli infection
RAB32_HUMAN	Q13637	RAB32	Ras-related protein Rab-32	1.084322843	2.705190719	1.311022545	0.573328771	1.894756781	0.942175658	1.894756781	0.942175658	2.01104408176081	0.224609	0	0.497254142298277	0.224066	0	GO:0005829,cytosol;GO:0005769,early endosome;GO:0012505,endomembrane system;GO:0005783,endoplasmic reticulum;GO:0042470,melanosome;GO:0033162,melanosome membrane;GO:0016020,membrane;GO:0044233,mitochondria-associated endoplasmic reticulum membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0045335,phagocytic vesicle;GO:0030670,phagocytic vesicle membrane;GO:0005802,trans-Golgi network	GO:0035650,AP-1 adaptor complex binding;GO:0035651,AP-3 adaptor complex binding;GO:0036461,BLOC-2 complex binding;GO:0005525,GTP binding;GO:0030742,GTP-dependent protein binding;GO:0003924,GTPase activity	GO:0019882,antigen processing and presentation;GO:0035646,endosome to melanosome transport;GO:0006886,intracellular protein transport;GO:1903232,melanosome assembly;GO:0032438,melanosome organization;GO:0007005,mitochondrion organization;GO:0090382,phagosome maturation;GO:0072657,protein localization to membrane;GO:0016192,vesicle-mediated transport	
SERC_HUMAN	Q9Y617	PSAT1	Phosphoserine aminotransferase	1.003595992	0.187477822	1.05882963	0.758885137	0.595536907	0.9088573835	0.595536907	0.9088573835	0.655258919398986	0.366294	0	1.52611428916865	0.366527	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0042802,identical protein binding;GO:0004648,O-phospho-L-serine;GO:0030170,pyridoxal phosphate binding	GO:0006564,L-serine biosynthetic process;GO:0008615,pyridoxine biosynthetic process	hsa:29968,path:hsa00260,Glycine, serine and threonine metabolism;hsa:29968,path:hsa00270,Cysteine and methionine metabolism;hsa:29968,path:hsa00750,Vitamin B6 metabolism
RL37A_HUMAN	P61513	RPL37A	60S ribosomal protein L37a	0.100623885	0.00248469	0.225701065	2.55E-05	0.0515542875	0.1128632825	0.0515542875	0.1128632825	0.456785292417842	0.185904	0	2.18921234242642	0.186240	0	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005634,nucleus;GO:0005840,ribosome	GO:0046872,metal ion binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6168,path:hsa03010,Ribosome
SYVC_HUMAN	P26640	VARS1	Valine--tRNA ligase	3.776688836	5.579290478	7.416117721	7.485199936	4.677989657	7.4506588285	4.677989657	7.4506588285	0.627862550772815	0.342021	0	1.59270528042982	0.342276	0	GO:0005829,cytosol	GO:0002161,aminoacyl-tRNA editing activity;GO:0005524,ATP binding;GO:0004832,valine-tRNA ligase activity;GO:0004812,aminoacyl-tRNA ligase activity	GO:0006418,tRNA aminoacylation for protein translation;GO:0006438,valyl-tRNA aminoacylation	hsa:7407,path:hsa00970,Aminoacyl-tRNA biosynthesis
H2B2F_HUMAN	Q5QNW6	H2BC18	Histone H2B type 2-F	495.8220964	196.7720959	69.0839309	76.68456292	346.29709615	72.88424691	346.29709615	72.88424691	4.75132982546447	0.069252	0	0.210467392653012	0.068796	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0000786,nucleosome;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0046982,protein heterodimerization activity	GO:0006334,nucleosome assembly	hsa:440689,path:hsa05203,Viral carcinogenesis;hsa:440689,path:hsa05322,Systemic lupus erythematosus;hsa:440689,path:hsa05034,Alcoholism
CUL5_HUMAN	Q93034	CUL5	Cullin-5	0.104354185	0.165694152	0.188620311	0.230064566	0.1350241685	0.2093424385	0.1350241685	0.2093424385	0.644991858638353	0.357250	0	1.55040716655108	0.357492	0	GO:0031466,Cul5-RING ubiquitin ligase complex;GO:0031461,cullin-RING ubiquitin ligase complex;GO:0005829,cytosol;GO:0019005,SCF ubiquitin ligase complex;GO:0090734,site of DNA damage	GO:0005262,calcium channel activity;GO:0038023,signaling receptor activity;GO:0031625,ubiquitin protein ligase binding;GO:0004842,ubiquitin-protein transferase activity	GO:0038128,ERBB2 signaling pathway;GO:0000082,G1/S transition of mitotic cell cycle;GO:0097193,intrinsic apoptotic signaling pathway;GO:0043687,post-translational protein modification;GO:0016567,protein ubiquitination;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0016032,viral process;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:8065,path:hsa04120,Ubiquitin mediated proteolysis;hsa:8065,path:hsa05170,Human immunodeficiency virus 1 infection
PDPR_HUMAN	Q8NCN5	PDPR	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial	0.277899344	0.312397919	0.423856823	0.171412328	0.2951486315	0.2976345755	0.2951486315	0.2976345755	0.991647663932109	0.436134	0	1.00842268516498	0.435943	0	GO:0005737,cytoplasm;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0016491,oxidoreductase activity	GO:0010510,regulation of acetyl-CoA biosynthetic process from pyruvate	
TIMP1_HUMAN	P01033	TIMP1	Metalloproteinase inhibitor 1	1.563150347	1.563954935	1.917761602	9.716690892	1.563552641	5.817226247	1.563552641	5.817226247	0.268779754235335	0.044234	-1	3.72051832119927	0.044439	1	GO:0005604,basement membrane;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0031093,platelet alpha granule lumen	GO:0005125,cytokine activity;GO:0004857,enzyme inhibitor activity;GO:0008083,growth factor activity;GO:0008191,metalloendopeptidase inhibitor activity;GO:0030414,peptidase inhibitor activity;GO:0002020,protease binding;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0007568,aging;GO:0051216,cartilage development;GO:0001775,cell activation;GO:0044267,cellular protein metabolic process;GO:0071492,cellular response to UV-A;GO:0002248,connective tissue replacement involved in inflammatory response wound healing;GO:0019221,cytokine-mediated signaling pathway;GO:0022617,extracellular matrix disassembly;GO:0043066,negative regulation of apoptotic process;GO:0043086,negative regulation of catalytic activity;GO:0010951,negative regulation of endopeptidase activity;GO:0051045,negative regulation of membrane protein ectodomain proteolysis;GO:1905049,negative regulation of metallopeptidase activity;GO:1901164,negative regulation of trophoblast cell migration;GO:0002576,platelet degranulation;GO:0008284,positive regulation of cell population proliferation;GO:0043687,post-translational protein modification;GO:2001044,regulation of integrin-mediated signaling pathway;GO:0034097,response to cytokine;GO:0009725,response to hormone;GO:0010033,response to organic substance;GO:0043434,response to peptide hormone	hsa:7076,path:hsa04066,HIF-1 signaling pathway
K1C14_HUMAN	P02533	KRT14	Keratin, type I cytoskeletal 14	139.2325272	53.79866167	85.41530497	70.62980799	96.515594435	78.02255648	96.515594435	78.02255648	1.23702168692384	0.364246	0	0.808393264702375	0.363908	0	GO:0045178,basal part of cell;GO:0071944,cell periphery;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005882,intermediate filament;GO:0045095,keratin filament;GO:0005634,nucleus	GO:1990254,keratin filament binding;GO:0005200,structural constituent of cytoskeleton	GO:0007568,aging;GO:0070268,cornification;GO:0008544,epidermis development;GO:0042633,hair cycle;GO:0031581,hemidesmosome assembly;GO:0045110,intermediate filament bundle assembly;GO:0031424,keratinization;GO:0010212,response to ionizing radiation;GO:0010043,response to zinc ion	hsa:3861,path:hsa04915,Estrogen signaling pathway;hsa:3861,path:hsa05150,Staphylococcus aureus infection
LV211_HUMAN	P01706	IGLV2-11	Immunoglobulin lambda variable 2-11	1.10688135	0.003571425	0.689487571	0.833809268	0.5552263875	0.7616484195	0.5552263875	0.7616484195	0.728979898447751	0.429066	0	1.3717799381428	0.429236	0	GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0070062,extracellular exosome	GO:0003823,antigen binding	GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
CDK5_HUMAN	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.201905093	0.205699666	0.109642028	0.085164738	0.2038023795	0.097403383	0.2038023795	0.097403383	2.09235422038678	0.214727	0	0.477930548401669	0.214176	0	GO:0030424,axon;GO:0030054,cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0030175,filopodium;GO:0098978,glutamatergic synapse;GO:0030426,growth cone;GO:0030027,lamellipodium;GO:0016020,membrane;GO:0005874,microtubule;GO:0031594,neuromuscular junction;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0043204,perikaryon;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0098793,presynapse;GO:0016533,protein kinase 5 complex;GO:0098685,Schaffer collateral - CA1 synapse	GO:0030549,acetylcholine receptor activator activity;GO:0005524,ATP binding;GO:0004693,cyclin-dependent protein serine/threonine kinase activity;GO:0046875,ephrin receptor binding;GO:0005176,ErbB-2 class receptor binding;GO:0043125,ErbB-3 class receptor binding;GO:0051879,Hsp90 protein binding;GO:0016301,kinase activity;GO:0002039,p53 binding;GO:0004672,protein kinase activity;GO:0019901,protein kinase binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0048156,tau protein binding;GO:0050321,tau-protein kinase activity;GO:0099635,voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels	GO:0048675,axon extension;GO:0007409,axonogenesis;GO:0048148,behavioral response to cocaine;GO:0070509,calcium ion import;GO:0051301,cell division;GO:0007160,cell-matrix adhesion;GO:1904646,cellular response to amyloid-beta;GO:0021954,central nervous system neuron development;GO:0021697,cerebellar cortex formation;GO:0007268,chemical synaptic transmission;GO:0022038,corpus callosum development;GO:0030866,cortical actin cytoskeleton organization;GO:0048813,dendrite morphogenesis;GO:0060079,excitatory postsynaptic potential;GO:0021766,hippocampus development;GO:0016572,histone phosphorylation;GO:0006886,intracellular protein transport;GO:0021819,layer formation in cerebral cortex;GO:0000226,microtubule cytoskeleton organization;GO:0007005,mitochondrion organization;GO:0008045,motor neuron axon guidance;GO:0030517,negative regulation of axon extension;GO:0045786,negative regulation of cell cycle;GO:1901215,negative regulation of neuron death;GO:0046826,negative regulation of protein export from nucleus;GO:0031397,negative regulation of protein ubiquitination;GO:0045861,negative regulation of proteolysis;GO:0031914,negative regulation of synaptic plasticity;GO:0045892,negative regulation of transcription, DNA-templated;GO:0051402,neuron apoptotic process;GO:0030182,neuron differentiation;GO:0001764,neuron migration;GO:0031175,neuron projection development;GO:0006913,nucleocytoplasmic transport;GO:0048709,oligodendrocyte differentiation;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:0016310,phosphorylation;GO:2000251,positive regulation of actin cytoskeleton reorganization;GO:0045956,positive regulation of calcium ion-dependent exocytosis;GO:0034352,positive regulation of glial cell apoptotic process;GO:0043525,positive regulation of neuron apoptotic process;GO:0032092,positive regulation of protein binding;GO:0045860,positive regulation of protein kinase activity;GO:0090314,positive regulation of protein targeting to membrane;GO:1901387,positive regulation of voltage-gated calcium channel activity;GO:0046777,protein autophosphorylation;GO:0035418,protein localization to synapse;GO:0006468,protein phosphorylation;GO:0032801,receptor catabolic process;GO:0043113,receptor clustering;GO:0042981,regulation of apoptotic process;GO:0071156,regulation of cell cycle arrest;GO:0030334,regulation of cell migration;GO:0061001,regulation of dendritic spine morphogenesis;GO:0016241,regulation of macroautophagy;GO:1903076,regulation of protein localization to plasma membrane;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0048167,regulation of synaptic plasticity;GO:0051966,regulation of synaptic transmission, glutamatergic;GO:1903421,regulation of synaptic vesicle recycling;GO:0000083,regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0009611,response to wounding;GO:0048511,rhythmic process;GO:0014044,Schwann cell development;GO:0019233,sensory perception of pain;GO:0042501,serine phosphorylation of STAT protein;GO:0007519,skeletal muscle tissue development;GO:0007416,synapse assembly;GO:0098883,synapse pruning;GO:0001963,synaptic transmission, dopaminergic;GO:0035249,synaptic transmission, glutamatergic;GO:0048488,synaptic vesicle endocytosis;GO:0016079,synaptic vesicle exocytosis;GO:0048489,synaptic vesicle transport;GO:0008542,visual learning	hsa:1020,path:hsa04360,Axon guidance;hsa:1020,path:hsa05010,Alzheimer disease;hsa:1020,path:hsa05030,Cocaine addiction
HECD1_HUMAN	Q9ULT8	HECTD1	E3 ubiquitin-protein ligase HECTD1	0.098052559	0.156549488	0.08805385	0.055763307	0.1273010235	0.0719085785	0.1273010235	0.0719085785	1.77031761933661	0.258086	0	0.564870387707448	0.257577	0		GO:0046872,metal ion binding;GO:0061630,ubiquitin protein ligase activity;GO:0004842,ubiquitin-protein transferase activity	GO:0048856,anatomical structure development;GO:0035904,aorta development;GO:0003170,heart valve development;GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0070534,protein K63-linked ubiquitination;GO:0003281,ventricular septum development;GO:0001779,natural killer cell differentiation;GO:1903077,negative regulation of protein localization to plasma membrane;GO:0001843,neural tube closure;GO:0051865,protein autoubiquitination;GO:0060708,spongiotrophoblast differentiation;GO:0060707,trophoblast giant cell differentiation	
SAE1_HUMAN	Q9UBE0	SAE1	SUMO-activating enzyme subunit 1	0.87254012	0.365174965	0.680047146	0.422667968	0.6188575425	0.551357557	0.6188575425	0.551357557	1.12242506635309	0.395431	0	0.890928071705614	0.395154	0	GO:0005737,cytoplasm;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0031510,SUMO activating enzyme complex	GO:0043008,ATP-dependent protein binding;GO:0008047,enzyme activator activity;GO:0008022,protein C-terminus binding;GO:0046982,protein heterodimerization activity;GO:0044388,small protein activating enzyme binding;GO:0004839,ubiquitin activating enzyme activity;GO:0008641,ubiquitin-like modifier activating enzyme activity	GO:0033235,positive regulation of protein sumoylation;GO:1903955,positive regulation of protein targeting to mitochondrion;GO:0032446,protein modification by small protein conjugation;GO:0016925,protein sumoylation	hsa:10055,path:hsa04120,Ubiquitin mediated proteolysis
PLAP_HUMAN	Q9Y263	PLAA	Phospholipase A-2-activating protein	0.117791815	0.208043597	0.294960484	0.271681103	0.162917706	0.2833207935	0.162917706	0.2833207935	0.5750291180093	0.294156	0	1.73904236964888	0.294448	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005634,nucleus;GO:0045202,synapse	GO:0016005,phospholipase A2 activator activity;GO:0043130,ubiquitin binding	GO:0071222,cellular response to lipopolysaccharide;GO:0006954,inflammatory response;GO:0016236,macroautophagy;GO:1900045,negative regulation of protein K63-linked ubiquitination;GO:0007399,nervous system development;GO:0006644,phospholipid metabolic process;GO:1903861,positive regulation of dendrite extension;GO:2001224,positive regulation of neuron migration;GO:0032430,positive regulation of phospholipase A2 activity;GO:1903423,positive regulation of synaptic vesicle recycling;GO:0006693,prostaglandin metabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0007165,signal transduction;GO:0010992,ubiquitin recycling;GO:0043162,ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	hsa:9373,path:hsa04141,Protein processing in endoplasmic reticulum
ENPP4_HUMAN	Q9Y6X5	ENPP4	Bis(5'-adenosyl)-triphosphatase ENPP4	0.067678395	0.089802193	0.189593618	0.050024826	0.078740294	0.119809222	0.078740294	0.119809222	0.65721396638399	0.368009	0	1.52157448129416	0.368241	0	GO:0070062,extracellular exosome;GO:0101003,ficolin-1-rich granule membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0047710,bis(5'-adenosyl)-triphosphatase activity;GO:0046872,metal ion binding	GO:0007596,blood coagulation;GO:0043312,neutrophil degranulation;GO:0030194,positive regulation of blood coagulation;GO:0046130,purine ribonucleoside catabolic process	hsa:22875,path:hsa00230,Purine metabolism
SNX6_HUMAN	Q9UNH7	SNX6	Sorting nexin-6	2.950796318	2.70162805	2.191821329	1.680530854	2.826212184	1.9361760915	2.826212184	1.9361760915	1.45968757511641	0.313257	0	0.685078106471004	0.312828	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0005768,endosome;GO:0005634,nucleus;GO:0030904,retromer complex;GO:0030905,retromer, tubulation complex;GO:0097422,tubular endosome;GO:0005764,lysosome	GO:0034452,dynactin binding;GO:0035091,phosphatidylinositol binding;GO:0042803,protein homodimerization activity;GO:0034713,type I transforming growth factor beta receptor binding	GO:1904646,cellular response to amyloid-beta;GO:0006886,intracellular protein transport;GO:0007175,negative regulation of epidermal growth factor-activated receptor activity;GO:0043524,negative regulation of neuron apoptotic process;GO:0045892,negative regulation of transcription, DNA-templated;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0016241,regulation of macroautophagy;GO:0042147,retrograde transport, endosome to Golgi;GO:0071364,cellular response to epidermal growth factor stimulus	hsa:58533,path:hsa04144,Endocytosis
PDK1_HUMAN	Q15118	PDK1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0.148134506	0.010210936	0.221847891	2.55E-05	0.079172721	0.1109366955	0.079172721	0.1109366955	0.713674773195313	0.416374	0	1.40119846960925	0.416557	0	GO:0005759,mitochondrial matrix;GO:0005967,mitochondrial pyruvate dehydrogenase complex;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0004672,protein kinase activity;GO:0004740,pyruvate dehydrogenase (acetyl-transferring) kinase activity	GO:0008283,cell population proliferation;GO:0006006,glucose metabolic process;GO:0097411,hypoxia-inducible factor-1alpha signaling pathway;GO:0008631,intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0006468,protein phosphorylation;GO:0010510,regulation of acetyl-CoA biosynthetic process from pyruvate;GO:0010906,regulation of glucose metabolic process	hsa:5163,path:hsa04066,HIF-1 signaling pathway;hsa:5163,path:hsa04360,Axon guidance;hsa:5163,path:hsa05230,Central carbon metabolism in cancer
TSR1_HUMAN	Q2NL82	TSR1	Pre-rRNA-processing protein TSR1 homolog	0.171824387	0.115118949	0.32283993	0.139810727	0.143471668	0.2313253285	0.143471668	0.2313253285	0.62021599160941	0.335171	0	1.61234152864244	0.335432	0	GO:0005829,cytosol;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0030688,preribosome, small subunit precursor;GO:0005634,nucleus	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0003723,RNA binding;GO:0034511,U3 snoRNA binding	GO:0000479,endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000462,maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0042254,ribosome biogenesis	
RBM26_HUMAN	Q5T8P6	RBM26	RNA-binding protein 26	0.192512733	0.016884051	0.021281724	0.115065184	0.104698392	0.068173454	0.104698392	0.068173454	1.53576481543681	0.298243	0	0.651141366144382	0.297789	0	GO:0005634,nucleus	GO:0046872,metal ion binding;GO:0003723,RNA binding	GO:0006397,mRNA processing;GO:0010923,negative regulation of phosphatase activity	
MP2K2_HUMAN	P36507	MAP2K2	Dual specificity mitogen-activated protein kinase kinase 2	1.032983716	0.88888597	1.493607653	0.769716917	0.960934843	1.131662285	0.960934843	1.131662285	0.849135696874443	0.488030	0	1.17766807317237	0.487953	0	GO:0005911,cell-cell junction;GO:0009898,cytoplasmic side of plasma membrane;GO:0005829,cytosol;GO:0005769,early endosome;GO:0005783,endoplasmic reticulum;GO:0005576,extracellular region;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0005770,late endosome;GO:0005874,microtubule;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005778,peroxisomal membrane	GO:0005524,ATP binding;GO:0004708,MAP kinase kinase activity;GO:0005078,MAP-kinase scaffold activity;GO:0046872,metal ion binding;GO:0030165,PDZ domain binding;GO:0106310,protein serine kinase activity;GO:0043539,protein serine/threonine kinase activator activity;GO:0004712,protein serine/threonine/tyrosine kinase activity;GO:0106311,protein threonine kinase activity;GO:0097110,scaffold protein binding;GO:0004714,transmembrane receptor protein tyrosine kinase activity;GO:0004672,protein kinase activity	GO:0000187,activation of MAPK activity;GO:0000186,activation of MAPKK activity;GO:0070371,ERK1 and ERK2 cascade;GO:0000165,MAPK cascade;GO:0010629,negative regulation of gene expression;GO:0036289,peptidyl-serine autophosphorylation;GO:1903800,positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:0071902,positive regulation of protein serine/threonine kinase activity;GO:0045893,positive regulation of transcription, DNA-templated;GO:2000641,regulation of early endosome to late endosome transport;GO:0090170,regulation of Golgi inheritance;GO:0032872,regulation of stress-activated MAPK cascade	hsa:5605,path:hsa04014,Ras signaling pathway;hsa:5605,path:hsa04015,Rap1 signaling pathway;hsa:5605,path:hsa04010,MAPK signaling pathway;hsa:5605,path:hsa04012,ErbB signaling pathway;hsa:5605,path:hsa04370,VEGF signaling pathway;hsa:5605,path:hsa04371,Apelin signaling pathway;hsa:5605,path:hsa04066,HIF-1 signaling pathway;hsa:5605,path:hsa04068,FoxO signaling pathway;hsa:5605,path:hsa04072,Phospholipase D signaling pathway;hsa:5605,path:hsa04071,Sphingolipid signaling pathway;hsa:5605,path:hsa04024,cAMP signaling pathway;hsa:5605,path:hsa04022,cGMP-PKG signaling pathway;hsa:5605,path:hsa04151,PI3K-Akt signaling pathway;hsa:5605,path:hsa04150,mTOR signaling pathway;hsa:5605,path:hsa04140,Autophagy - animal;hsa:5605,path:hsa04210,Apoptosis;hsa:5605,path:hsa04218,Cellular senescence;hsa:5605,path:hsa04540,Gap junction;hsa:5605,path:hsa04550,Signaling pathways regulating pluripotency of stem cells;hsa:5605,path:hsa04810,Regulation of actin cytoskeleton;hsa:5605,path:hsa04620,Toll-like receptor signaling pathway;hsa:5605,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:5605,path:hsa04660,T cell receptor signaling pathway;hsa:5605,path:hsa04662,B cell receptor signaling pathway;hsa:5605,path:hsa04664,Fc epsilon RI signaling pathway;hsa:5605,path:hsa04910,Insulin signaling pathway;hsa:5605,path:hsa04929,GnRH secretion;hsa:5605,path:hsa04912,GnRH signaling pathway;hsa:5605,path:hsa04915,Estrogen signaling pathway;hsa:5605,path:hsa04917,Prolactin signaling pathway;hsa:5605,path:hsa04921,Oxytocin signaling pathway;hsa:5605,path:hsa04926,Relaxin signaling pathway;hsa:5605,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:5605,path:hsa04919,Thyroid hormone signaling pathway;hsa:5605,path:hsa04916,Melanogenesis;hsa:5605,path:hsa04270,Vascular smooth muscle contraction;hsa:5605,path:hsa04720,Long-term potentiation;hsa:5605,path:hsa04730,Long-term depression;hsa:5605,path:hsa04722,Neurotrophin signaling pathway;hsa:5605,path:hsa05200,Pathways in cancer;hsa:5605,path:hsa05206,MicroRNAs in cancer;hsa:5605,path:hsa05205,Proteoglycans in cancer;hsa:5605,path:hsa05230,Central carbon metabolism in cancer;hsa:5605,path:hsa05231,Choline metabolism in cancer;hsa:5605,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:5605,path:hsa05210,Colorectal cancer;hsa:5605,path:hsa05225,Hepatocellular carcinoma;hsa:5605,path:hsa05226,Gastric cancer;hsa:5605,path:hsa05214,Glioma;hsa:5605,path:hsa05216,Thyroid cancer;hsa:5605,path:hsa05221,Acute myeloid leukemia;hsa:5605,path:hsa05220,Chronic myeloid leukemia;hsa:5605,path:hsa05218,Melanoma;hsa:5605,path:hsa05211,Renal cell carcinoma;hsa:5605,path:hsa05219,Bladder cancer;hsa:5605,path:hsa05215,Prostate cancer;hsa:5605,path:hsa05213,Endometrial cancer;hsa:5605,path:hsa05224,Breast cancer;hsa:5605,path:hsa05223,Non-small cell lung cancer;hsa:5605,path:hsa05020,Prion diseases;hsa:5605,path:hsa04934,Cushing syndrome;hsa:5605,path:hsa05132,Salmonella infection;hsa:5605,path:hsa05135,Yersinia infection;hsa:5605,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:5605,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:5605,path:hsa05164,Influenza A;hsa:5605,path:hsa05161,Hepatitis B;hsa:5605,path:hsa05160,Hepatitis C;hsa:5605,path:hsa05163,Human cytomegalovirus infection;hsa:5605,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:5605,path:hsa05165,Human papillomavirus infection;hsa:5605,path:hsa01521,EGFR tyrosine kinase inhibitor resistance;hsa:5605,path:hsa01522,Endocrine resistance
PROS_HUMAN	P07225	PROS1	Vitamin K-dependent protein S	0.104462938	0.084221142	0.301668987	2.35455667	0.09434204	1.3281128285	0.09434204	1.3281128285	0.0710346575799226	0.000093	-1	14.0776352567742	0.000095	1	GO:0072562,blood microparticle;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005796,Golgi lumen;GO:0000139,Golgi membrane;GO:0005886,plasma membrane;GO:0031093,platelet alpha granule lumen	GO:0005509,calcium ion binding;GO:0004866,endopeptidase inhibitor activity	GO:0007596,blood coagulation;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0042730,fibrinolysis;GO:0050900,leukocyte migration;GO:0002576,platelet degranulation;GO:0030449,regulation of complement activation;GO:0030195,negative regulation of blood coagulation	hsa:5627,path:hsa04610,Complement and coagulation cascades
MAP1B_HUMAN	P46821	MAP1B	Microtubule-associated protein 1B	1.109396135	0.901823846	0.726727203	0.689605205	1.0056099905	0.708166204	1.0056099905	0.708166204	1.42001974228637	0.321533	0	0.704215561390646	0.321117	0	GO:0097440,apical dendrite;GO:0030424,axon;GO:0097441,basal dendrite;GO:0005829,cytosol;GO:0030425,dendrite;GO:0043197,dendritic spine;GO:0030426,growth cone;GO:0097457,hippocampal mossy fiber;GO:0005874,microtubule;GO:0005875,microtubule associated complex;GO:0043025,neuronal cell body;GO:0043204,perikaryon;GO:0048471,perinuclear region of cytoplasm;GO:0001750,photoreceptor outer segment;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0036477,somatodendritic compartment;GO:0045202,synapse;GO:0043196,varicosity	GO:0003779,actin binding;GO:0008017,microtubule binding;GO:0005543,phospholipid binding;GO:0044877,protein-containing complex binding;GO:0005198,structural molecule activity	GO:0048675,axon extension;GO:0007409,axonogenesis;GO:0009987,cellular process;GO:0071363,cellular response to growth factor stimulus;GO:0071375,cellular response to peptide hormone stimulus;GO:0016358,dendrite development;GO:0021700,developmental maturation;GO:0061162,establishment of monopolar cell polarity;GO:0051915,induction of synaptic plasticity by chemical substance;GO:0001578,microtubule bundle formation;GO:0000226,microtubule cytoskeleton organization;GO:0047497,mitochondrion transport along microtubule;GO:0032387,negative regulation of intracellular transport;GO:0007026,negative regulation of microtubule depolymerization;GO:0001764,neuron migration;GO:0014012,peripheral nervous system axon regeneration;GO:0045773,positive regulation of axon extension;GO:0031116,positive regulation of microtubule polymerization;GO:0045666,positive regulation of neuron differentiation;GO:0031114,regulation of microtubule depolymerization;GO:0009743,response to carbohydrate;GO:0042493,response to drug;GO:0032355,response to estradiol;GO:0010035,response to inorganic substance;GO:0017085,response to insecticide;GO:0009612,response to mechanical stimulus;GO:0033189,response to vitamin A;GO:0007416,synapse assembly;GO:0007399,nervous system development	
DNM1L_HUMAN	O00429	DNM1L	Dynamin-1-like protein	0.983723065	0.629584436	1.39953508	1.145754695	0.8066537505	1.2726448875	0.8066537505	1.2726448875	0.633840404674552	0.347355	0	1.57768421297385	0.347605	0	GO:0005903,brush border;GO:0005905,clathrin-coated pit;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005874,microtubule;GO:0031966,mitochondrial membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0048471,perinuclear region of cytoplasm;GO:0005777,peroxisome;GO:0098835,presynaptic endocytic zone membrane;GO:0032991,protein-containing complex;GO:0030672,synaptic vesicle membrane	GO:0051433,BH2 domain binding;GO:0030276,clathrin binding;GO:0005525,GTP binding;GO:0030742,GTP-dependent protein binding;GO:0005096,GTPase activator activity;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0008289,lipid binding;GO:0008017,microtubule binding;GO:0042803,protein homodimerization activity;GO:0044877,protein-containing complex binding;GO:0031267,small GTPase binding;GO:0031625,ubiquitin protein ligase binding	GO:0006816,calcium ion transport;GO:0090650,cellular response to oxygen-glucose deprivation;GO:1904579,cellular response to thapsigargin;GO:0003374,dynamin family protein polymerization involved in mitochondrial fission;GO:0097194,execution phase of apoptosis;GO:0060047,heart contraction;GO:0048312,intracellular distribution of mitochondria;GO:0061025,membrane fusion;GO:0000266,mitochondrial fission;GO:0043653,mitochondrial fragmentation involved in apoptotic process;GO:0090149,mitochondrial membrane fission;GO:0070584,mitochondrion morphogenesis;GO:0007005,mitochondrion organization;GO:0070266,necroptotic process;GO:0010637,negative regulation of mitochondrial fusion;GO:0016559,peroxisome fission;GO:0043065,positive regulation of apoptotic process;GO:0061003,positive regulation of dendritic spine morphogenesis;GO:2001244,positive regulation of intrinsic apoptotic signaling pathway;GO:0090141,positive regulation of mitochondrial fission;GO:0090023,positive regulation of neutrophil chemotaxis;GO:0050714,positive regulation of protein secretion;GO:0090200,positive regulation of release of cytochrome c from mitochondria;GO:1900244,positive regulation of synaptic vesicle endocytosis;GO:2000302,positive regulation of synaptic vesicle exocytosis;GO:0051259,protein complex oligomerization;GO:0070585,protein localization to mitochondrion;GO:0065003,protein-containing complex assembly;GO:1903578,regulation of ATP metabolic process;GO:1903146,regulation of autophagy of mitochondrion;GO:0010468,regulation of gene expression;GO:0010821,regulation of mitochondrion organization;GO:1900063,regulation of peroxisome organization;GO:1904666,regulation of ubiquitin protein ligase activity;GO:0001836,release of cytochrome c from mitochondria;GO:1905395,response to flavonoid;GO:1990910,response to hypobaric hypoxia;GO:0048511,rhythmic process;GO:0048488,synaptic vesicle endocytosis;GO:0036466,synaptic vesicle recycling via endosome	hsa:10059,path:hsa04668,TNF signaling pathway;hsa:10059,path:hsa04217,Necroptosis;hsa:10059,path:hsa04621,NOD-like receptor signaling pathway
ST1A1_HUMAN	P50225	SULT1A1	Sulfotransferase 1A1	0.417284592	0.470261177	0.556629927	0.559002671	0.4437728845	0.557816299	0.4437728845	0.557816299	0.795553814572206	0.481975	0	1.25698599099513	0.482086	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016021,integral component of membrane	GO:0050656,3'-phosphoadenosine 5'-phosphosulfate binding;GO:0004062,aryl sulfotransferase activity;GO:0047894,flavonol 3-sulfotransferase activity;GO:0050294,steroid sulfotransferase activity;GO:0008146,sulfotransferase activity	GO:0050427,3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0009308,amine metabolic process;GO:0006584,catecholamine metabolic process;GO:0008210,estrogen metabolic process;GO:0006068,ethanol catabolic process;GO:0009812,flavonoid metabolic process;GO:0051923,sulfation;GO:0006805,xenobiotic metabolic process	hsa:6817,path:hsa05204,Chemical carcinogenesis
Z3H7B_HUMAN	Q9UGR2	ZC3H7B	Zinc finger CCCH domain-containing protein 7B	0.01247117	0.016895918	0.030646436	0.031937908	0.014683544	0.031292172	0.014683544	0.031292172	0.469240166518323	0.197113	0	2.1311048613332	0.197448	0	GO:0005634,nucleus	GO:0046872,metal ion binding;GO:0035198,miRNA binding;GO:0003723,RNA binding	GO:0010608,posttranscriptional regulation of gene expression;GO:0035196,production of miRNAs involved in gene silencing by miRNA;GO:0016032,viral process	
FERM2_HUMAN	Q96AC1	FERMT2	Fermitin family homolog 2	2.012501928	1.578084661	2.352538868	8.950400926	1.7952932945	5.651469897	1.7952932945	5.651469897	0.317668381362697	0.073788	0	3.14793683812759	0.074053	0	GO:0005912,adherens junction;GO:0005938,cell cortex;GO:0030054,cell junction;GO:0009986,cell surface;GO:0030055,cell-substrate junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0005925,focal adhesion;GO:0031674,I band;GO:0031258,lamellipodium membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0001725,stress fiber;GO:0005856,cytoskeleton	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0005178,integrin binding;GO:0005547,phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019901,protein kinase binding;GO:0046332,SMAD binding;GO:0034713,type I transforming growth factor beta receptor binding	GO:0034334,adherens junction maintenance;GO:0007155,cell adhesion;GO:0034329,cell junction assembly;GO:0007160,cell-matrix adhesion;GO:0048041,focal adhesion assembly;GO:0033622,integrin activation;GO:0007229,integrin-mediated signaling pathway;GO:0060173,limb development;GO:0060548,negative regulation of cell death;GO:0045599,negative regulation of fat cell differentiation;GO:0043116,negative regulation of vascular permeability;GO:0030335,positive regulation of cell migration;GO:0010718,positive regulation of epithelial to mesenchymal transition;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0051894,positive regulation of focal adhesion assembly;GO:0043547,positive regulation of GTPase activity;GO:0033625,positive regulation of integrin activation;GO:1902462,positive regulation of mesenchymal stem cell proliferation;GO:0035505,positive regulation of myosin light chain kinase activity;GO:0045669,positive regulation of osteoblast differentiation;GO:0051897,positive regulation of protein kinase B signaling;GO:1900182,positive regulation of protein localization to nucleus;GO:0051496,positive regulation of stress fiber assembly;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:1903691,positive regulation of wound healing, spreading of epidermal cells;GO:1902414,protein localization to cell junction;GO:0072657,protein localization to membrane;GO:0022604,regulation of cell morphogenesis;GO:0008360,regulation of cell shape;GO:0034446,substrate adhesion-dependent cell spreading;GO:0007179,transforming growth factor beta receptor signaling pathway;GO:0016055,Wnt signaling pathway	
SNAG_HUMAN	Q99747	NAPG	Gamma-soluble NSF attachment protein	0.271534092	0.04975206	0.268856992	0.08012759	0.160643076	0.174492291	0.160643076	0.174492291	0.920631364740348	0.460908	0	1.08621109197386	0.460771	0	GO:0070062,extracellular exosome;GO:0005765,lysosomal membrane;GO:0005739,mitochondrion;GO:0031201,SNARE complex;GO:0045202,synapse;GO:0005774,vacuolar membrane;GO:0016020,membrane	GO:0005483,soluble NSF attachment protein activity;GO:0019905,syntaxin binding	GO:0006891,intra-Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0061025,membrane fusion;GO:0050821,protein stabilization;GO:0065003,protein-containing complex assembly	
PYR1_HUMAN	P27708	CAD	CAD protein	1.866977896	1.127096714	2.175398535	1.213211896	1.497037305	1.6943052155	1.497037305	1.6943052155	0.883570026996709	0.474678	0	1.13177220757368	0.474572	0	GO:0042995,cell projection;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0043025,neuronal cell body;GO:0016363,nuclear matrix;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0043195,terminal bouton	GO:0070335,aspartate binding;GO:0004070,aspartate carbamoyltransferase activity;GO:0005524,ATP binding;GO:0004088,carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity;GO:0004151,dihydroorotase activity;GO:0019899,enzyme binding;GO:0042802,identical protein binding;GO:0004672,protein kinase activity;GO:0008270,zinc ion binding;GO:0016812,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0046872,metal ion binding;GO:0016597,amino acid binding;GO:0016743,carboxyl- or carbamoyltransferase activity;GO:0016810,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	GO:0006207,'de novo' pyrimidine nucleobase biosynthetic process;GO:0044205,'de novo' UMP biosynthetic process;GO:0031100,animal organ regeneration;GO:0035690,cellular response to drug;GO:0071364,cellular response to epidermal growth factor stimulus;GO:0019240,citrulline biosynthetic process;GO:0017144,drug metabolic process;GO:0007565,female pregnancy;GO:0006541,glutamine metabolic process;GO:0007507,heart development;GO:0007595,lactation;GO:0001889,liver development;GO:0006807,nitrogen compound metabolic process;GO:0018107,peptidyl-threonine phosphorylation;GO:0046777,protein autophosphorylation;GO:0046134,pyrimidine nucleoside biosynthetic process;GO:0014075,response to amine;GO:0031000,response to caffeine;GO:0051414,response to cortisol;GO:0032868,response to insulin;GO:0042594,response to starvation;GO:0033574,response to testosterone;GO:0006228,UTP biosynthetic process;GO:0006520,cellular amino acid metabolic process	hsa:790,path:hsa00240,Pyrimidine metabolism;hsa:790,path:hsa00250,Alanine, aspartate and glutamate metabolism
FBLN4_HUMAN	O95967	EFEMP2	EGF-containing fibulin-like extracellular matrix protein 2	0.500499507	0.169382871	0.1303041	0.997179834	0.334941189	0.563741967	0.334941189	0.563741967	0.594139178217328	0.311599	0	1.68310732007344	0.311879	0	GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0071953,elastic fiber;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:1903561,extracellular vesicle;GO:0001527,microfibril;GO:0005615,extracellular space	GO:0005509,calcium ion binding;GO:0005201,extracellular matrix structural constituent;GO:0008201,heparin binding;GO:0042803,protein homodimerization activity	GO:0035904,aorta development;GO:0060414,aorta smooth muscle tissue morphogenesis;GO:0048251,elastic fiber assembly;GO:1904706,negative regulation of vascular associated smooth muscle cell proliferation;GO:1904831,positive regulation of aortic smooth muscle cell differentiation;GO:1904028,positive regulation of collagen fibril organization;GO:1905609,positive regulation of smooth muscle cell-matrix adhesion;GO:1904026,regulation of collagen fibril organization;GO:0097084,vascular associated smooth muscle cell development	
TNS2_HUMAN	Q63HR2	TNS2	Tensin-2	0.009287109	0.010693707	0.022768758	0.082510083	0.009990408	0.0526394205	0.009990408	0.0526394205	0.189789475360961	0.012698	-1	5.26899607103133	0.012790	1	GO:0005925,focal adhesion;GO:0005886,plasma membrane	GO:0042802,identical protein binding;GO:0019900,kinase binding;GO:0046872,metal ion binding;GO:0004725,protein tyrosine phosphatase activity	GO:0019725,cellular homeostasis;GO:0032963,collagen metabolic process;GO:0035556,intracellular signal transduction;GO:0001822,kidney development;GO:0035264,multicellular organism growth;GO:0048871,multicellular organismal homeostasis;GO:0008285,negative regulation of cell population proliferation;GO:0046627,negative regulation of insulin receptor signaling pathway;GO:0035335,peptidyl-tyrosine dephosphorylation;GO:0014850,response to muscle activity	
RO60_HUMAN	P10155	RO60	60 kDa SS-A/Ro ribonucleoprotein	1.969433045	1.222599717	2.554354488	2.158103081	1.596016381	2.3562287845	1.596016381	2.3562287845	0.677360531158557	0.385530	0	1.47631867225804	0.385745	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:1990904,ribonucleoprotein complex;GO:0005737,cytoplasm	GO:0046872,metal ion binding;GO:0003723,RNA binding;GO:0030620,U2 snRNA binding	GO:0035457,cellular response to interferon-alpha;GO:0060271,cilium assembly;GO:0002520,immune system development;GO:0010468,regulation of gene expression;GO:0009411,response to UV;GO:0007224,smoothened signaling pathway;GO:0006383,transcription by RNA polymerase III	hsa:6738,path:hsa05322,Systemic lupus erythematosus
NOP58_HUMAN	Q9Y2X3	NOP58	Nucleolar protein 58	0.862224529	1.400247284	1.794490768	1.422056134	1.1312359065	1.608273451	1.1312359065	1.608273451	0.703385301670319	0.407736	0	1.4216959007038	0.407928	0	GO:0031428,box C/D RNP complex;GO:0015030,Cajal body;GO:0005829,cytosol;GO:0001650,fibrillar center;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0070761,pre-snoRNP complex;GO:0032040,small-subunit processome;GO:0005732,sno(s)RNA-containing ribonucleoprotein complex	GO:0051117,ATPase binding;GO:0003723,RNA binding;GO:0030515,snoRNA binding;GO:0001094,TFIID-class transcription factor complex binding	GO:0006364,rRNA processing;GO:0048254,snoRNA localization	hsa:51602,path:hsa03008,Ribosome biogenesis in eukaryotes
AAAT_HUMAN	Q15758	SLC1A5	Neutral amino acid transporter B(0)	0.437059865	0.28862054	0.943512167	2.760205421	0.3628402025	1.851858794	0.3628402025	1.851858794	0.195932974844301	0.014385	-1	5.10378613296028	0.014485	1	GO:0009925,basal plasma membrane;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0042470,melanosome;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0015183,L-aspartate transmembrane transporter activity;GO:0015186,L-glutamine transmembrane transporter activity;GO:0015194,L-serine transmembrane transporter activity;GO:0046872,metal ion binding;GO:0015175,neutral amino acid transmembrane transporter activity;GO:0038023,signaling receptor activity;GO:0015293,symporter activity;GO:0001618,virus receptor activity	GO:0006865,amino acid transport;GO:0010585,glutamine secretion;GO:0006868,glutamine transport;GO:0140009,L-aspartate import across plasma membrane;GO:1903803,L-glutamine import across plasma membrane;GO:0015804,neutral amino acid transport;GO:0070207,protein homotrimerization;GO:0150104,transport across blood-brain barrier	hsa:6510,path:hsa04974,Protein digestion and absorption;hsa:6510,path:hsa05230,Central carbon metabolism in cancer
PGM2_HUMAN	Q96G03	PGM2	Phosphoglucomutase-2	4.300430512	9.772807758	9.456400717	12.4038285	7.036619135	10.9301146085	7.036619135	10.9301146085	0.643782740350028	0.356181	0	1.55331905831507	0.356423	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0034774,secretory granule lumen	GO:0000287,magnesium ion binding;GO:0004614,phosphoglucomutase activity;GO:0008973,phosphopentomutase activity;GO:0016868,intramolecular transferase activity, phosphotransferases;GO:0046872,metal ion binding	GO:0046386,deoxyribose phosphate catabolic process;GO:0019388,galactose catabolic process;GO:0006006,glucose metabolic process;GO:0005978,glycogen biosynthetic process;GO:0005980,glycogen catabolic process;GO:0043312,neutrophil degranulation;GO:0006098,pentose-phosphate shunt;GO:0005975,carbohydrate metabolic process	hsa:55276,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:55276,path:hsa00030,Pentose phosphate pathway;hsa:55276,path:hsa00052,Galactose metabolism;hsa:55276,path:hsa00500,Starch and sucrose metabolism;hsa:55276,path:hsa00520,Amino sugar and nucleotide sugar metabolism;hsa:55276,path:hsa00230,Purine metabolism
KCC1D_HUMAN	Q8IU85	CAMK1D	Calcium/calmodulin-dependent protein kinase type 1D	0.171148451	0.097825272	0.126342496	2.55E-05	0.1344868615	0.063183998	0.1344868615	0.063183998	2.12849559630589	0.210537	0	0.469815395312798	0.209982	0	GO:0005737,cytoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0005516,calmodulin binding;GO:0004683,calmodulin-dependent protein kinase activity;GO:0106310,protein serine kinase activity;GO:0106311,protein threonine kinase activity;GO:0004672,protein kinase activity	GO:0006954,inflammatory response;GO:0043066,negative regulation of apoptotic process;GO:0007399,nervous system development;GO:0018105,peptidyl-serine phosphorylation;GO:0043065,positive regulation of apoptotic process;GO:0032793,positive regulation of CREB transcription factor activity;GO:0010976,positive regulation of neuron projection development;GO:0090023,positive regulation of neutrophil chemotaxis;GO:0050766,positive regulation of phagocytosis;GO:0060267,positive regulation of respiratory burst;GO:0050773,regulation of dendrite development;GO:0071622,regulation of granulocyte chemotaxis	hsa:57118,path:hsa04020,Calcium signaling pathway;hsa:57118,path:hsa04921,Oxytocin signaling pathway;hsa:57118,path:hsa04925,Aldosterone synthesis and secretion;hsa:57118,path:hsa05214,Glioma
PACN2_HUMAN	Q9UNF0	PACSIN2	Protein kinase C and casein kinase substrate in neurons protein 2	3.159506016	3.057593003	4.18170422	4.376399091	3.1085495095	4.2790516555	3.1085495095	4.2790516555	0.726457579801469	0.426987	0	1.37654286747657	0.427159	0	GO:0005901,caveola;GO:0005911,cell-cell junction;GO:0005737,cytoplasm;GO:0030659,cytoplasmic vesicle membrane;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005769,early endosome;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0019898,extrinsic component of membrane;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0043231,intracellular membrane-bounded organelle;GO:0016607,nuclear speck;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0032587,ruffle membrane	GO:0045296,cadherin binding;GO:0008092,cytoskeletal protein binding;GO:0042802,identical protein binding;GO:0070300,phosphatidic acid binding;GO:0005543,phospholipid binding;GO:0005215,transporter activity	GO:0030036,actin cytoskeleton organization;GO:0070836,caveola assembly;GO:0072584,caveolin-mediated endocytosis;GO:0048858,cell projection morphogenesis;GO:0007010,cytoskeleton organization;GO:0061024,membrane organization;GO:0050804,modulation of chemical synaptic transmission;GO:0045806,negative regulation of endocytosis;GO:0097320,plasma membrane tubulation;GO:0036010,protein localization to endosome;GO:0030100,regulation of endocytosis	
MBOA7_HUMAN	Q96N66	MBOAT7	Lysophospholipid acyltransferase 7	0.474065697	0.609804203	0.763877622	0.709597513	0.54193495	0.7367375675	0.54193495	0.7367375675	0.7355875061984	0.434487	0	1.35945756497159	0.434651	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0044233,mitochondria-associated endoplasmic reticulum membrane	GO:0071617,lysophospholipid acyltransferase activity;GO:0008374,O-acyltransferase activity;GO:0016746,transferase activity, transferring acyl groups	GO:0021819,layer formation in cerebral cortex;GO:0030258,lipid modification;GO:0036151,phosphatidylcholine acyl-chain remodeling;GO:0036149,phosphatidylinositol acyl-chain remodeling;GO:0006661,phosphatidylinositol biosynthetic process;GO:0090207,regulation of triglyceride metabolic process;GO:0021591,ventricular system development	hsa:79143,path:hsa00564,Glycerophospholipid metabolism
DDX18_HUMAN	Q9NVP1	DDX18	ATP-dependent RNA helicase DDX18	0.047228099	0.50753338	0.015611876	2.55E-05	0.2773807395	0.007818688	0.2773807395	0.007818688	35.476634890662	0.000747	1	0.0281875663540799	0.000728	-1	GO:0005694,chromosome;GO:0016020,membrane;GO:0005730,nucleolus	GO:0005524,ATP binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0004386,helicase activity;GO:0016787,hydrolase activity;GO:0003676,nucleic acid binding	GO:0071392,cellular response to estradiol stimulus;GO:0000463,maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	
PSB3_HUMAN	P49720	PSMB3	Proteasome subunit beta type-3	2.511846484	5.398558326	1.324018016	0.534592212	3.955202405	0.929305114	3.955202405	0.929305114	4.25608591345813	0.082476	0	0.234957663057954	0.081986	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000502,proteasome complex;GO:0005839,proteasome core complex;GO:0019774,proteasome core complex, beta-subunit complex	GO:0004175,endopeptidase activity;GO:0004298,threonine-type endopeptidase activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5691,path:hsa03050,Proteasome
PGS2_HUMAN	P07585	DCN	Decorin	6.274564307	11.5821783	10.63194983	58.62241143	8.9283713035	34.62718063	8.9283713035	34.62718063	0.257842860465652	0.038612	-1	3.87833115950564	0.038802	1	GO:0005589,collagen type VI trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005796,Golgi lumen;GO:0043202,lysosomal lumen	GO:0005518,collagen binding;GO:0050840,extracellular matrix binding;GO:0030021,extracellular matrix structural constituent conferring compression resistance;GO:0005539,glycosaminoglycan binding;GO:0047485,protein N-terminus binding;GO:0003723,RNA binding	GO:0007568,aging;GO:0009887,animal organ morphogenesis;GO:0030206,chondroitin sulfate biosynthetic process;GO:0030207,chondroitin sulfate catabolic process;GO:0030208,dermatan sulfate biosynthetic process;GO:0030198,extracellular matrix organization;GO:0001822,kidney development;GO:0016525,negative regulation of angiogenesis;GO:0010596,negative regulation of endothelial cell migration;GO:1900747,negative regulation of vascular endothelial growth factor signaling pathway;GO:0019800,peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan;GO:0001890,placenta development;GO:0010508,positive regulation of autophagy;GO:0016239,positive regulation of macroautophagy;GO:0051901,positive regulation of mitochondrial depolarization;GO:0090141,positive regulation of mitochondrial fission;GO:0014068,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0032496,response to lipopolysaccharide;GO:0009612,response to mechanical stimulus;GO:0007519,skeletal muscle tissue development;GO:0042060,wound healing	hsa:1634,path:hsa04350,TGF-beta signaling pathway;hsa:1634,path:hsa05205,Proteoglycans in cancer
ARFP1_HUMAN	P53367	ARFIP1	Arfaptin-1	0.77490012	0.574691008	1.007226123	1.692237095	0.674795564	1.349731609	0.674795564	1.349731609	0.499947959653955	0.225092	0	2.00020818305202	0.225421	0	GO:0005829,cytosol;GO:0000139,Golgi membrane;GO:0032588,trans-Golgi network membrane	GO:0070273,phosphatidylinositol-4-phosphate binding;GO:0005543,phospholipid binding;GO:0019904,protein domain specific binding	GO:0006886,intracellular protein transport;GO:1905280,negative regulation of retrograde transport, endosome to Golgi;GO:0034315,regulation of Arp2/3 complex-mediated actin nucleation;GO:0050708,regulation of protein secretion	
CALL3_HUMAN	P27482	CALML3	Calmodulin-like protein 3	2.450838194	3.153359604	0.207047699	0.032677619	2.802098899	0.119862659	2.802098899	0.119862659	23.377579993449	0.002369	1	0.0427760272996703	0.002322	-1	GO:0070062,extracellular exosome	GO:0005509,calcium ion binding;GO:0030234,enzyme regulator activity		hsa:810,path:hsa04014,Ras signaling pathway;hsa:810,path:hsa04015,Rap1 signaling pathway;hsa:810,path:hsa04371,Apelin signaling pathway;hsa:810,path:hsa04020,Calcium signaling pathway;hsa:810,path:hsa04070,Phosphatidylinositol signaling system;hsa:810,path:hsa04024,cAMP signaling pathway;hsa:810,path:hsa04022,cGMP-PKG signaling pathway;hsa:810,path:hsa04114,Oocyte meiosis;hsa:810,path:hsa04218,Cellular senescence;hsa:810,path:hsa04625,C-type lectin receptor signaling pathway;hsa:810,path:hsa04910,Insulin signaling pathway;hsa:810,path:hsa04922,Glucagon signaling pathway;hsa:810,path:hsa04912,GnRH signaling pathway;hsa:810,path:hsa04915,Estrogen signaling pathway;hsa:810,path:hsa04921,Oxytocin signaling pathway;hsa:810,path:hsa04916,Melanogenesis;hsa:810,path:hsa04924,Renin secretion;hsa:810,path:hsa04925,Aldosterone synthesis and secretion;hsa:810,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:810,path:hsa04270,Vascular smooth muscle contraction;hsa:810,path:hsa04970,Salivary secretion;hsa:810,path:hsa04971,Gastric acid secretion;hsa:810,path:hsa04728,Dopaminergic synapse;hsa:810,path:hsa04720,Long-term potentiation;hsa:810,path:hsa04722,Neurotrophin signaling pathway;hsa:810,path:hsa04744,Phototransduction;hsa:810,path:hsa04740,Olfactory transduction;hsa:810,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:810,path:hsa04713,Circadian entrainment;hsa:810,path:hsa05200,Pathways in cancer;hsa:810,path:hsa05214,Glioma;hsa:810,path:hsa05010,Alzheimer disease;hsa:810,path:hsa05031,Amphetamine addiction;hsa:810,path:hsa05034,Alcoholism;hsa:810,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:810,path:hsa05133,Pertussis;hsa:810,path:hsa05152,Tuberculosis;hsa:810,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:810,path:hsa05163,Human cytomegalovirus infection;hsa:810,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection
DIP2B_HUMAN	Q9P265	DIP2B	Disco-interacting protein 2 homolog B	0.542300312	0.707585583	0.949179103	1.05330137	0.6249429475	1.0012402365	0.6249429475	1.0012402365	0.624168830534209	0.338716	0	1.60213062729218	0.338974	0	GO:0030424,axon;GO:0005737,cytoplasm;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005634,nucleus;GO:0043204,perikaryon	GO:0043014,alpha-tubulin binding	GO:0030517,negative regulation of axon extension;GO:2000758,positive regulation of peptidyl-lysine acetylation	
ACOC_HUMAN	P21399	ACO1	Cytoplasmic aconitate hydratase	6.154164438	9.050356605	6.870672077	8.00716544	7.6022605215	7.4389187585	7.6022605215	7.4389187585	1.02195772911397	0.426161	0	0.978514053479481	0.425949	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0005739,mitochondrion	GO:0051538,3 iron, 4 sulfur cluster binding;GO:0051539,4 iron, 4 sulfur cluster binding;GO:0003994,aconitate hydratase activity;GO:0047780,citrate dehydratase activity;GO:0030350,iron-responsive element binding;GO:0046872,metal ion binding;GO:0003723,RNA binding	GO:0006879,cellular iron ion homeostasis;GO:0006101,citrate metabolic process;GO:0050892,intestinal absorption;GO:0009791,post-embryonic development;GO:0006417,regulation of translation;GO:0010040,response to iron(II) ion;GO:0006099,tricarboxylic acid cycle	hsa:48,path:hsa00020,Citrate cycle (TCA cycle);hsa:48,path:hsa00630,Glyoxylate and dicarboxylate metabolism
RRP44_HUMAN	Q9Y2L1	DIS3	Exosome complex exonuclease RRP44	0.343724882	0.167060154	0.451584807	0.559243487	0.255392518	0.505414147	0.255392518	0.505414147	0.50531335443604	0.230016	0	1.97897006129209	0.230343	0	GO:0000177,cytoplasmic exosome (RNase complex);GO:0005829,cytosol;GO:0000178,exosome (RNase complex);GO:0016020,membrane;GO:0000176,nuclear exosome (RNase complex);GO:0005654,nucleoplasm	GO:0000175,3'-5'-exoribonuclease activity;GO:0004519,endonuclease activity;GO:0005085,guanyl-nucleotide exchange factor activity;GO:0003723,RNA binding;GO:0004540,ribonuclease activity	GO:0071034,CUT catabolic process;GO:0043928,exonucleolytic catabolism of deadenylated mRNA;GO:0043488,regulation of mRNA stability;GO:0016075,rRNA catabolic process;GO:0006364,rRNA processing	hsa:22894,path:hsa03018,RNA degradation
OPA1_HUMAN	O60313	OPA1	Dynamin-like 120 kDa protein, mitochondrial	1.314385338	1.238698764	2.756180001	1.656374619	1.276542051	2.20627731	1.276542051	2.20627731	0.578595467221661	0.297420	0	1.72832325286243	0.297710	0	GO:1904115,axon cytoplasm;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0031314,extrinsic component of mitochondrial inner membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0030061,mitochondrial crista;GO:0005743,mitochondrial inner membrane;GO:0005758,mitochondrial intermembrane space;GO:0031966,mitochondrial membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:1901612,cardiolipin binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0019900,kinase binding;GO:0000287,magnesium ion binding;GO:0008017,microtubule binding;GO:0070300,phosphatidic acid binding;GO:0044877,protein-containing complex binding;GO:0008289,lipid binding	GO:0006915,apoptotic process;GO:0019896,axonal transport of mitochondrion;GO:0036444,calcium import into the mitochondrion;GO:0071333,cellular response to glucose stimulus;GO:0071456,cellular response to hypoxia;GO:1905232,cellular response to L-glutamate;GO:0090398,cellular senescence;GO:0090102,cochlea development;GO:0003374,dynamin family protein polymerization involved in mitochondrial fission;GO:0046039,GTP metabolic process;GO:0007007,inner mitochondrial membrane organization;GO:0048312,intracellular distribution of mitochondria;GO:0061025,membrane fusion;GO:0097749,membrane tubulation;GO:0000266,mitochondrial fission;GO:0008053,mitochondrial fusion;GO:0000002,mitochondrial genome maintenance;GO:0070584,mitochondrion morphogenesis;GO:0007005,mitochondrion organization;GO:0043066,negative regulation of apoptotic process;GO:1902236,negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0090201,negative regulation of release of cytochrome c from mitochondria;GO:0001843,neural tube closure;GO:1900006,positive regulation of dendrite development;GO:0061003,positive regulation of dendritic spine morphogenesis;GO:0046628,positive regulation of insulin receptor signaling pathway;GO:0010636,positive regulation of mitochondrial fusion;GO:0014042,positive regulation of neuron maturation;GO:0051259,protein complex oligomerization;GO:1904643,response to curcumin;GO:0051602,response to electrical stimulus;GO:0014850,response to muscle activity;GO:0031667,response to nutrient levels;GO:0060041,retina development in camera-type eye;GO:0007601,visual perception	hsa:4976,path:hsa05017,Spinocerebellar ataxia
YBOX3_HUMAN	P16989	YBX3	Y-box-binding protein 3	0.071402749	2.55E-05	0.064602431	2.55E-05	0.0357141245	0.0323139655	0.0357141245	0.0323139655	1.10522258557217	0.400453	0	0.904795118245164	0.400187	0	GO:0005923,bicellular tight junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm	GO:0003730,mRNA 3'-UTR binding;GO:0003676,nucleic acid binding;GO:1905538,polysome binding;GO:0003723,RNA binding;GO:0000977,RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0031267,small GTPase binding	GO:0070935,3'-UTR-mediated mRNA stabilization;GO:0071474,cellular hyperosmotic response;GO:0071356,cellular response to tumor necrosis factor;GO:0009566,fertilization;GO:0001701,in utero embryonic development;GO:0008584,male gonad development;GO:1902219,negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;GO:0060546,negative regulation of necroptotic process;GO:0048642,negative regulation of skeletal muscle tissue development;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:2000767,positive regulation of cytoplasmic translation;GO:0046622,positive regulation of organ growth;GO:0010468,regulation of gene expression;GO:0007283,spermatogenesis	hsa:8531,path:hsa04530,Tight junction
IRGQ_HUMAN	Q8WZA9	IRGQ	Immunity-related GTPase family Q protein	0.318242445	0.210749245	0.225341728	0.199863862	0.264495845	0.212602795	0.264495845	0.212602795	1.24408451450509	0.362445	0	0.803803912307205	0.362104	0		GO:0005525,GTP binding		
RT22_HUMAN	P82650	MRPS22	28S ribosomal protein S22, mitochondrial	0.938902966	0.419510489	0.962196622	0.844296339	0.6792067275	0.9032464805	0.6792067275	0.9032464805	0.751961665130452	0.447762	0	1.32985502635499	0.447911	0	GO:0005743,mitochondrial inner membrane;GO:0005761,mitochondrial ribosome;GO:0005763,mitochondrial small ribosomal subunit;GO:0005739,mitochondrion;GO:0005840,ribosome	GO:0003735,structural constituent of ribosome	GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination	
CUL2_HUMAN	Q13617	CUL2	Cullin-2	0.577887258	0.532862997	0.932471363	0.496311041	0.5553751275	0.714391202	0.5553751275	0.714391202	0.777410368360052	0.467938	0	1.2863219230141	0.468065	0	GO:0031462,Cul2-RING ubiquitin ligase complex;GO:0031461,cullin-RING ubiquitin ligase complex;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0019005,SCF ubiquitin ligase complex;GO:0030891,VCB complex	GO:0044877,protein-containing complex binding;GO:0031625,ubiquitin protein ligase binding;GO:0004842,ubiquitin-protein transferase activity	GO:0000082,G1/S transition of mitotic cell cycle;GO:0097193,intrinsic apoptotic signaling pathway;GO:0043687,post-translational protein modification;GO:0016567,protein ubiquitination;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0016032,viral process;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:8453,path:hsa04120,Ubiquitin mediated proteolysis;hsa:8453,path:hsa04066,HIF-1 signaling pathway;hsa:8453,path:hsa05200,Pathways in cancer;hsa:8453,path:hsa05211,Renal cell carcinoma
PLEK_HUMAN	P08567	PLEK	Pleckstrin	0.217862727	0.218373336	0.712149938	0.262197297	0.2181180315	0.4871736175	0.2181180315	0.4871736175	0.447721353671209	0.177816	0	2.23353206587141	0.178152	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0032587,ruffle membrane	GO:0043325,phosphatidylinositol-3,4-bisphosphate binding;GO:0042803,protein homodimerization activity;GO:0005080,protein kinase C binding	GO:0031532,actin cytoskeleton reorganization;GO:0030030,cell projection organization;GO:0030866,cortical actin cytoskeleton organization;GO:0002244,hematopoietic progenitor cell differentiation;GO:0007229,integrin-mediated signaling pathway;GO:0050849,negative regulation of calcium-mediated signaling;GO:0045744,negative regulation of G protein-coupled receptor signaling pathway;GO:0010920,negative regulation of inositol phosphate biosynthetic process;GO:0046488,phosphatidylinositol metabolic process;GO:0030845,phospholipase C-inhibiting G protein-coupled receptor signaling pathway;GO:0070527,platelet aggregation;GO:0002576,platelet degranulation;GO:0032233,positive regulation of actin filament bundle assembly;GO:0030836,positive regulation of actin filament depolymerization;GO:0010925,positive regulation of inositol-polyphosphate 5-phosphatase activity;GO:0033625,positive regulation of integrin activation;GO:0010572,positive regulation of platelet activation;GO:0070528,protein kinase C signaling;GO:0070560,protein secretion by platelet;GO:0060305,regulation of cell diameter;GO:0031529,ruffle organization;GO:0070493,thrombin-activated receptor signaling pathway;GO:0006904,vesicle docking involved in exocytosis	
GGT5_HUMAN	P36269	GGT5	Glutathione hydrolase 5 proenzyme	0.915884611	0.998043294	0.667186992	1.712183764	0.9569639525	1.189685378	0.9569639525	1.189685378	0.804384058337145	0.488700	0	1.24318724325199	0.488803	0	GO:0016021,integral component of membrane;GO:0031226,intrinsic component of plasma membrane;GO:0005886,plasma membrane	GO:0036374,glutathione hydrolase activity;GO:0102953,hypoglycin A gamma-glutamyl transpeptidase activity;GO:0103068,leukotriene C4 gamma-glutamyl transferase activity;GO:0002951,leukotriene-C(4) hydrolase;GO:0000048,peptidyltransferase activity	GO:0006520,cellular amino acid metabolic process;GO:0006631,fatty acid metabolic process;GO:0006750,glutathione biosynthetic process;GO:0006751,glutathione catabolic process;GO:0006954,inflammatory response;GO:1901750,leukotriene D4 biosynthetic process;GO:0006691,leukotriene metabolic process;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0006508,proteolysis;GO:0032355,response to estradiol;GO:0032496,response to lipopolysaccharide;GO:0034612,response to tumor necrosis factor;GO:0007283,spermatogenesis	hsa:2687,path:hsa00590,Arachidonic acid metabolism;hsa:2687,path:hsa00430,Taurine and hypotaurine metabolism;hsa:2687,path:hsa00480,Glutathione metabolism
NAKD2_HUMAN	Q4G0N4	NADK2	NAD kinase 2, mitochondrial	0.290752954	0.272753433	0.490857502	0.25590021	0.2817531935	0.373378856	0.2817531935	0.373378856	0.754604040835135	0.449883	0	1.32519831048517	0.450030	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0003951,NAD+ kinase activity;GO:0042803,protein homodimerization activity	GO:0019674,NAD metabolic process;GO:0006741,NADP biosynthetic process	hsa:133686,path:hsa00760,Nicotinate and nicotinamide metabolism
UBQL1_HUMAN	Q9UMX0	UBQLN1	Ubiquilin-1	3.917711036	0.236176927	1.102281409	2.825785417	2.0769439815	1.964033413	2.0769439815	1.964033413	1.05748912811393	0.414898	0	0.945636199384418	0.414662	0	GO:0016235,aggresome;GO:0005776,autophagosome;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0000502,proteasome complex;GO:0032991,protein-containing complex;GO:0005634,nucleus	GO:0042802,identical protein binding;GO:0019900,kinase binding;GO:0031593,polyubiquitin modification-dependent protein binding	GO:0035973,aggrephagy;GO:0000045,autophagosome assembly;GO:0097352,autophagosome maturation;GO:0071456,cellular response to hypoxia;GO:0016236,macroautophagy;GO:1901340,negative regulation of store-operated calcium channel activity;GO:1903071,positive regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:0031398,positive regulation of protein ubiquitination;GO:0016241,regulation of macroautophagy;GO:1902175,regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:0031396,regulation of protein ubiquitination;GO:0034976,response to endoplasmic reticulum stress;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:29979,path:hsa04141,Protein processing in endoplasmic reticulum
LSP1_HUMAN	P33241	LSP1	Lymphocyte-specific protein 1	0.247579394	0.546666139	0.762837804	0.180589478	0.3971227665	0.471713641	0.3971227665	0.471713641	0.841872551444829	0.490917	0	1.18782825058709	0.490847	0	GO:0015629,actin cytoskeleton;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0003779,actin binding	GO:0006968,cellular defense response;GO:0007165,signal transduction	hsa:4046,path:hsa04625,C-type lectin receptor signaling pathway;hsa:4046,path:hsa05152,Tuberculosis
WBP2_HUMAN	Q969T9	WBP2	WW domain-binding protein 2	0.481428536	0.82316503	0.123577335	3.557316082	0.652296783	1.8404467085	0.652296783	1.8404467085	0.354423075651908	0.100126	0	2.82148671657637	0.100425	0	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005634,nucleus	GO:0031490,chromatin DNA binding;GO:0030331,estrogen receptor binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003713,transcription coactivator activity	GO:0071391,cellular response to estrogen stimulus;GO:0045184,establishment of protein localization;GO:0045815,positive regulation of gene expression, epigenetic;GO:0071442,positive regulation of histone H3-K14 acetylation;GO:0033148,positive regulation of intracellular estrogen receptor signaling pathway;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0050847,progesterone receptor signaling pathway;GO:0043627,response to estrogen;GO:0032570,response to progesterone	
SYMC_HUMAN	P56192	MARS1	Methionine--tRNA ligase, cytoplasmic	3.11506295	1.454808751	2.639858517	2.350768596	2.2849358505	2.4953135565	2.2849358505	2.4953135565	0.915690873617069	0.462709	0	1.0920716027778	0.462576	0	GO:0017101,aminoacyl-tRNA synthetase multienzyme complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005730,nucleolus	GO:0005524,ATP binding;GO:0004825,methionine-tRNA ligase activity;GO:0000049,tRNA binding;GO:0004812,aminoacyl-tRNA ligase activity	GO:0071364,cellular response to epidermal growth factor stimulus;GO:0032869,cellular response to insulin stimulus;GO:0036120,cellular response to platelet-derived growth factor stimulus;GO:0009267,cellular response to starvation;GO:0006431,methionyl-tRNA aminoacylation;GO:1901838,positive regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0009303,rRNA transcription;GO:0006418,tRNA aminoacylation for protein translation	hsa:4141,path:hsa00450,Selenocompound metabolism;hsa:4141,path:hsa00970,Aminoacyl-tRNA biosynthesis
TMX1_HUMAN	Q9H3N1	TMX1	Thioredoxin-related transmembrane protein 1	1.405180975	3.132903796	1.329491167	1.147313045	2.2690423855	1.238402106	2.2690423855	1.238402106	1.83223395253173	0.248812	0	0.545781830217821	0.248293	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane	GO:0015036,disulfide oxidoreductase activity	GO:0034976,response to endoplasmic reticulum stress	
SIN3A_HUMAN	Q96ST3	SIN3A	Paired amphipathic helix protein Sin3a	0.135618272	0.093857497	0.240354297	0.369777516	0.1147378845	0.3050659065	0.1147378845	0.3050659065	0.376108513128785	0.117008	0	2.6588071396767	0.117322	0	GO:0000785,chromatin;GO:0000118,histone deacetylase complex;GO:0000776,kinetochore;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016580,Sin3 complex;GO:0017053,transcription repressor complex	GO:0003682,chromatin binding;GO:0003677,DNA binding;GO:0044877,protein-containing complex binding;GO:0003723,RNA binding;GO:0001102,RNA polymerase II activating transcription factor binding;GO:0001103,RNA polymerase II repressing transcription factor binding;GO:0003713,transcription coactivator activity;GO:0003714,transcription corepressor activity;GO:0140416,transcription regulator inhibitor activity	GO:0002218,activation of innate immune response;GO:0007568,aging;GO:0034613,cellular protein localization;GO:1903351,cellular response to dopamine;GO:0071333,cellular response to glucose stimulus;GO:0021895,cerebral cortex neuron differentiation;GO:0006260,DNA replication;GO:0002244,hematopoietic progenitor cell differentiation;GO:0016575,histone deacetylation;GO:0001701,in utero embryonic development;GO:0043066,negative regulation of apoptotic process;GO:0042754,negative regulation of circadian rhythm;GO:1901675,negative regulation of histone H3-K27 acetylation;GO:1900181,negative regulation of protein localization to nucleus;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:2000678,negative regulation of transcription regulatory region DNA binding;GO:0045892,negative regulation of transcription, DNA-templated;GO:0031937,positive regulation of chromatin silencing;GO:0002230,positive regulation of defense response to virus by host;GO:0010971,positive regulation of G2/M transition of mitotic cell cycle;GO:0045666,positive regulation of neuron differentiation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0006476,protein deacetylation;GO:0030516,regulation of axon extension;GO:0010817,regulation of hormone levels;GO:0019216,regulation of lipid metabolic process;GO:0045652,regulation of megakaryocyte differentiation;GO:0043619,regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0051595,response to methylglyoxal;GO:0048511,rhythmic process	hsa:25942,path:hsa04919,Thyroid hormone signaling pathway;hsa:25942,path:hsa05202,Transcriptional misregulation in cancer;hsa:25942,path:hsa05016,Huntington disease;hsa:25942,path:hsa05169,Epstein-Barr virus infection
PAR14_HUMAN	Q460N5	PARP14	Protein mono-ADP-ribosyltransferase PARP14	0.211789365	0.325216753	0.68136747	0.149173765	0.268503059	0.4152706175	0.268503059	0.4152706175	0.646573698414866	0.358648	0	1.54661410207621	0.358888	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0019899,enzyme binding;GO:0003950,NAD+ ADP-ribosyltransferase activity;GO:0070403,NAD+ binding;GO:1990404,protein ADP-ribosylase activity;GO:0003714,transcription corepressor activity	GO:0045087,innate immune response;GO:0010629,negative regulation of gene expression;GO:0060336,negative regulation of interferon-gamma-mediated signaling pathway;GO:0042532,negative regulation of tyrosine phosphorylation of STAT protein;GO:1902216,positive regulation of interleukin-4-mediated signaling pathway;GO:0042531,positive regulation of tyrosine phosphorylation of STAT protein;GO:0006471,protein ADP-ribosylation;GO:0140289,protein mono-ADP-ribosylation;GO:0070212,protein poly-ADP-ribosylation	
UD17_HUMAN	Q9HAW7	UGT1A7	UDP-glucuronosyltransferase 1A7	2.55E-05	0.013940419	0.050324553	0.053739412	0.0069829595	0.0520319825	0.0069829595	0.0520319825	0.134205140078989	0.002847	-1	7.45127943245267	0.002877	1	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane	GO:0008144,drug binding;GO:0019899,enzyme binding;GO:0004857,enzyme inhibitor activity;GO:0015020,glucuronosyltransferase activity;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0005080,protein kinase C binding;GO:0001972,retinoic acid binding;GO:0008194,UDP-glycosyltransferase activity	GO:0052695,cellular glucuronidation;GO:0009804,coumarin metabolic process;GO:0017144,drug metabolic process;GO:0008210,estrogen metabolic process;GO:0007588,excretion;GO:0006631,fatty acid metabolic process;GO:0051552,flavone metabolic process;GO:0052696,flavonoid glucuronidation;GO:2001030,negative regulation of cellular glucuronidation;GO:0045922,negative regulation of fatty acid metabolic process;GO:1904224,negative regulation of glucuronosyltransferase activity;GO:0042573,retinoic acid metabolic process;GO:0052697,xenobiotic glucuronidation	hsa:54577,path:hsa00040,Pentose and glucuronate interconversions;hsa:54577,path:hsa00053,Ascorbate and aldarate metabolism;hsa:54577,path:hsa00140,Steroid hormone biosynthesis;hsa:54577,path:hsa00830,Retinol metabolism;hsa:54577,path:hsa00860,Porphyrin and chlorophyll metabolism;hsa:54577,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:54577,path:hsa00982,Drug metabolism - cytochrome P450;hsa:54577,path:hsa00983,Drug metabolism - other enzymes;hsa:54577,path:hsa05204,Chemical carcinogenesis
GDIR1_HUMAN	P52565	ARHGDIA	Rho GDP-dissociation inhibitor 1	7.742316103	22.35743512	8.240775378	6.319721885	15.0498756115	7.2802486315	15.0498756115	7.2802486315	2.06722000487491	0.217713	0	0.483741448729116	0.217164	0	GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005737,cytoplasm;GO:0005615,extracellular space;GO:0001772,immunological synapse;GO:0005634,nucleus;GO:0045202,synapse	GO:0005096,GTPase activator activity;GO:0005094,Rho GDP-dissociation inhibitor activity;GO:0005504,fatty acid binding;GO:0051879,Hsp90 protein binding;GO:0019901,protein kinase binding;GO:0031267,small GTPase binding	GO:0043066,negative regulation of apoptotic process;GO:0050771,negative regulation of axonogenesis;GO:0007162,negative regulation of cell adhesion;GO:0050772,positive regulation of axonogenesis;GO:0043547,positive regulation of GTPase activity;GO:2000249,regulation of actin cytoskeleton reorganization;GO:0035023,regulation of Rho protein signal transduction;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007266,Rho protein signal transduction;GO:0071526,semaphorin-plexin signaling pathway;GO:0071260,cellular response to mechanical stimulus;GO:0071407,cellular response to organic cyclic compound;GO:0071461,cellular response to redox state;GO:0030336,negative regulation of cell migration;GO:0008360,regulation of cell shape;GO:0032880,regulation of protein localization	hsa:396,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:396,path:hsa04722,Neurotrophin signaling pathway
PRPS2_HUMAN	P11908	PRPS2	Ribose-phosphate pyrophosphokinase 2	6.919692073	7.427714602	9.684489316	7.406614811	7.1737033375	8.5455520635	7.1737033375	8.5455520635	0.83946634274695	0.491879	0	1.19123298824315	0.491811	0	GO:0005737,cytoplasm;GO:0002189,ribose phosphate diphosphokinase complex	GO:0043531,ADP binding;GO:0016208,AMP binding;GO:0005524,ATP binding;GO:0030246,carbohydrate binding;GO:0019003,GDP binding;GO:0042802,identical protein binding;GO:0016301,kinase activity;GO:0000287,magnesium ion binding;GO:0042803,protein homodimerization activity;GO:0004749,ribose phosphate diphosphokinase activity	GO:0006015,5-phosphoribose 1-diphosphate biosynthetic process;GO:0006167,AMP biosynthetic process;GO:0031100,animal organ regeneration;GO:0006139,nucleobase-containing compound metabolic process;GO:0009116,nucleoside metabolic process;GO:0006164,purine nucleotide biosynthetic process;GO:0009165,nucleotide biosynthetic process;GO:0009156,ribonucleoside monophosphate biosynthetic process	hsa:5634,path:hsa00030,Pentose phosphate pathway;hsa:5634,path:hsa00230,Purine metabolism
I2BPL_HUMAN	Q9H1B7	IRF2BPL	Probable E3 ubiquitin-protein ligase IRF2BPL	0.090731614	0.062851958	0.100353556	0.063123706	0.076791786	0.081738631	0.076791786	0.081738631	0.939479717980596	0.454132	0	1.06441893407714	0.453980	0	GO:0005615,extracellular space;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0046872,metal ion binding;GO:0003714,transcription corepressor activity;GO:0061630,ubiquitin protein ligase activity	GO:0046543,development of secondary female sexual characteristics;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0007399,nervous system development;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0006357,regulation of transcription by RNA polymerase II	
CD81_HUMAN	P60033	CD81	CD81 antigen	0.466142083	1.306097174	0.408171299	1.164450796	0.8861196285	0.7863110475	0.8861196285	0.7863110475	1.12693269580446	0.394130	0	0.88736443952951	0.393851	0	GO:0009925,basal plasma membrane;GO:0016323,basolateral plasma membrane;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0001772,immunological synapse;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0097197,tetraspanin-enriched microdomain;GO:0031982,vesicle	GO:0015485,cholesterol binding;GO:0005178,integrin binding;GO:0042289,MHC class II protein binding;GO:0023026,MHC class II protein complex binding;GO:1990459,transferrin receptor binding;GO:0001618,virus receptor activity	GO:0000187,activation of MAPK activity;GO:0035783,CD4-positive, alpha-beta T cell costimulation;GO:0071404,cellular response to low-density lipoprotein particle stimulus;GO:0002455,humoral immune response mediated by circulating immunoglobulin;GO:0001771,immunological synapse formation;GO:0034238,macrophage fusion;GO:0014905,myoblast fusion involved in skeletal muscle regeneration;GO:0072675,osteoclast fusion;GO:0043128,positive regulation of 1-phosphatidylinositol 4-kinase activity;GO:1905676,positive regulation of adaptive immune memory response;GO:0030890,positive regulation of B cell proliferation;GO:0050861,positive regulation of B cell receptor signaling pathway;GO:2000563,positive regulation of CD4-positive, alpha-beta T cell proliferation;GO:0008284,positive regulation of cell population proliferation;GO:0002863,positive regulation of inflammatory response to antigenic stimulus;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:1904352,positive regulation of protein catabolic process in the vacuole;GO:0070863,positive regulation of protein exit from endoplasmic reticulum;GO:1903911,positive regulation of receptor clustering;GO:2001190,positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0050862,positive regulation of T cell receptor signaling pathway;GO:2000553,positive regulation of T-helper 2 cell cytokine production;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0008104,protein localization;GO:0061462,protein localization to lysosome;GO:0072659,protein localization to plasma membrane;GO:0031623,receptor internalization;GO:0046813,receptor-mediated virion attachment to host cell;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:1905521,regulation of macrophage migration;GO:0031647,regulation of protein stability;GO:0046718,viral entry into host cell;GO:0050871,positive regulation of B cell activation	hsa:975,path:hsa04662,B cell receptor signaling pathway;hsa:975,path:hsa05160,Hepatitis C;hsa:975,path:hsa05144,Malaria
SYWC_HUMAN	P23381	WARS1	Tryptophan--tRNA ligase, cytoplasmic	13.53696558	5.714499771	20.69483585	12.57083237	9.6257326755	16.63283411	9.6257326755	16.63283411	0.578718732588862	0.297533	0	1.72795512515477	0.297823	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0005524,ATP binding;GO:0019210,kinase inhibitor activity;GO:0019904,protein domain specific binding;GO:0042803,protein homodimerization activity;GO:0019901,protein kinase binding;GO:0004830,tryptophan-tRNA ligase activity;GO:0004812,aminoacyl-tRNA ligase activity	GO:0001525,angiogenesis;GO:0008285,negative regulation of cell population proliferation;GO:0006469,negative regulation of protein kinase activity;GO:0001933,negative regulation of protein phosphorylation;GO:0010628,positive regulation of gene expression;GO:0031334,positive regulation of protein-containing complex assembly;GO:0045765,regulation of angiogenesis;GO:0010835,regulation of protein ADP-ribosylation;GO:0006412,translation;GO:0006418,tRNA aminoacylation for protein translation;GO:0006436,tryptophanyl-tRNA aminoacylation	hsa:7453,path:hsa00970,Aminoacyl-tRNA biosynthesis
TOP2B_HUMAN	Q02880	TOP2B	DNA topoisomerase 2-beta	1.042131911	0.510872191	1.435019193	0.77619831	0.776502051	1.1056087515	0.776502051	1.1056087515	0.702329870260619	0.406845	0	1.42383236473898	0.407038	0	GO:0005829,cytosol;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex	GO:0005524,ATP binding;GO:0003682,chromatin binding;GO:0003677,DNA binding;GO:0003918,DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity;GO:0019899,enzyme binding;GO:0042826,histone deacetylase binding;GO:0046872,metal ion binding;GO:0008022,protein C-terminus binding;GO:0046982,protein heterodimerization activity;GO:0005080,protein kinase C binding	GO:0007409,axonogenesis;GO:0006265,DNA topological change;GO:0030900,forebrain development;GO:0001764,neuron migration;GO:0045870,positive regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0000712,resolution of meiotic recombination intermediates;GO:0000819,sister chromatid segregation	hsa:7155,path:hsa01524,Platinum drug resistance
RCN3_HUMAN	Q96D15	RCN3	Reticulocalbin-3	1.192131763	1.26988868	1.030013309	0.056035386	1.2310102215	0.5430243475	1.2310102215	0.5430243475	2.26695216737036	0.195535	0	0.441120908678011	0.194972	0	GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0043231,intracellular membrane-bounded organelle	GO:0005509,calcium ion binding	GO:0032964,collagen biosynthetic process;GO:0036503,ERAD pathway;GO:0060428,lung epithelium development;GO:0055091,phospholipid homeostasis;GO:0010952,positive regulation of peptidase activity;GO:0009306,protein secretion;GO:0015031,protein transport;GO:0051896,regulation of protein kinase B signaling;GO:0043129,surfactant homeostasis	
C4BPA_HUMAN	P04003	C4BPA	C4b-binding protein alpha chain	1.312634102	1.387054763	2.147413138	15.18459864	1.3498444325	8.666005889	1.3498444325	8.666005889	0.15576315661329	0.005586	-1	6.42000343176583	0.005637	1	GO:0072562,blood microparticle;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane	GO:0003723,RNA binding	GO:0006958,complement activation, classical pathway;GO:0045087,innate immune response;GO:0045959,negative regulation of complement activation, classical pathway;GO:0045732,positive regulation of protein catabolic process;GO:0030449,regulation of complement activation;GO:1903027,regulation of opsonization;GO:0009609,response to symbiotic bacterium	hsa:722,path:hsa04610,Complement and coagulation cascades;hsa:722,path:hsa05133,Pertussis
VTNC_HUMAN	P04004	VTN	Vitronectin	6.463522808	4.34717806	5.636638332	28.28618029	5.405350434	16.961409311	5.405350434	16.961409311	0.318685218597635	0.074473	0	3.1378926339931	0.074739	0	GO:0071062,alphav-beta3 integrin-vitronectin complex;GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043231,intracellular membrane-bounded organelle	GO:0005201,extracellular matrix structural constituent;GO:0008201,heparin binding;GO:0005178,integrin binding;GO:0030247,polysaccharide binding;GO:0005044,scavenger receptor activity	GO:0007155,cell adhesion;GO:0033627,cell adhesion mediated by integrin;GO:0016477,cell migration;GO:0007160,cell-matrix adhesion;GO:0035987,endodermal cell differentiation;GO:0030198,extracellular matrix organization;GO:0006955,immune response;GO:0030195,negative regulation of blood coagulation;GO:0010951,negative regulation of endopeptidase activity;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0032092,positive regulation of protein binding;GO:0048260,positive regulation of receptor-mediated endocytosis;GO:0014911,positive regulation of smooth muscle cell migration;GO:0030949,positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0090303,positive regulation of wound healing;GO:0030449,regulation of complement activation;GO:0061302,smooth muscle cell-matrix adhesion	hsa:7448,path:hsa04151,PI3K-Akt signaling pathway;hsa:7448,path:hsa04512,ECM-receptor interaction;hsa:7448,path:hsa04510,Focal adhesion;hsa:7448,path:hsa04610,Complement and coagulation cascades;hsa:7448,path:hsa05205,Proteoglycans in cancer;hsa:7448,path:hsa05165,Human papillomavirus infection
SET_HUMAN	Q01105	SET	Protein SET	2.23852259	2.582710806	2.583266168	0.273358087	2.410616698	1.4283121275	2.410616698	1.4283121275	1.68773803119585	0.271264	0	0.592509015923194	0.270772	0	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005811,lipid droplet;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0032991,protein-containing complex	GO:0003682,chromatin binding;GO:0003677,DNA binding;GO:0042393,histone binding;GO:0004864,protein phosphatase inhibitor activity;GO:0019888,protein phosphatase regulator activity	GO:0006260,DNA replication;GO:0007076,mitotic chromosome condensation;GO:0035067,negative regulation of histone acetylation;GO:0043524,negative regulation of neuron apoptotic process;GO:0045892,negative regulation of transcription, DNA-templated;GO:0006334,nucleosome assembly;GO:0006337,nucleosome disassembly;GO:0043488,regulation of mRNA stability;GO:0016032,viral process	
TERA_HUMAN	P55072	VCP	Transitional endoplasmic reticulum ATPase	26.85506946	24.01152368	42.03995343	45.05335127	25.43329657	43.54665235	25.43329657	43.54665235	0.584047112636432	0.302402	0	1.71219064072747	0.302689	0	GO:1904949,ATPase complex;GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0036513,Derlin-1 retrotranslocation complex;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0098978,glutamatergic synapse;GO:0043231,intracellular membrane-bounded organelle;GO:0005811,lipid droplet;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0000502,proteasome complex;GO:0032991,protein-containing complex;GO:0034774,secretory granule lumen;GO:0035861,site of double-strand break;GO:0034098,VCP-NPL4-UFD1 AAA ATPase complex;GO:1990730,VCP-NSFL1C complex	GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:1904288,BAT3 complex binding;GO:0035800,deubiquitinase activator activity;GO:0042802,identical protein binding;GO:0036435,K48-linked polyubiquitin modification-dependent protein binding;GO:0008289,lipid binding;GO:0042288,MHC class I protein binding;GO:0031593,polyubiquitin modification-dependent protein binding;GO:0019904,protein domain specific binding;GO:0019903,protein phosphatase binding;GO:0003723,RNA binding;GO:0031625,ubiquitin protein ligase binding;GO:0044389,ubiquitin-like protein ligase binding;GO:1990381,ubiquitin-specific protease binding	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0070842,aggresome assembly;GO:0046034,ATP metabolic process;GO:0097352,autophagosome maturation;GO:0006914,autophagy;GO:1903843,cellular response to arsenite ion;GO:0006974,cellular response to DNA damage stimulus;GO:0034605,cellular response to heat;GO:0006281,DNA repair;GO:0006302,double-strand break repair;GO:0061857,endoplasmic reticulum stress-induced pre-emptive quality control;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0030968,endoplasmic reticulum unfolded protein response;GO:0032510,endosome to lysosome transport via multivesicular body sorting pathway;GO:0071712,ER-associated misfolded protein catabolic process;GO:0036503,ERAD pathway;GO:0070987,error-free translesion synthesis;GO:0045184,establishment of protein localization;GO:0072389,flavin adenine dinucleotide catabolic process;GO:0036297,interstrand cross-link repair;GO:0016236,macroautophagy;GO:0051228,mitotic spindle disassembly;GO:0006734,NADH metabolic process;GO:0045879,negative regulation of smoothened signaling pathway;GO:0043312,neutrophil degranulation;GO:2001171,positive regulation of ATP biosynthetic process;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:1903007,positive regulation of Lys63-specific deubiquitinase activity;GO:0010918,positive regulation of mitochondrial membrane potential;GO:1903862,positive regulation of oxidative phosphorylation;GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0045732,positive regulation of protein catabolic process;GO:1903006,positive regulation of protein K63-linked deubiquitination;GO:0031334,positive regulation of protein-containing complex assembly;GO:0010498,proteasomal protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0006457,protein folding;GO:0016567,protein ubiquitination;GO:0106300,protein-DNA covalent cross-linking repair;GO:1903715,regulation of aerobic respiration;GO:0042981,regulation of apoptotic process;GO:1905634,regulation of protein localization to chromatin;GO:0050807,regulation of synapse organization;GO:0030970,retrograde protein transport, ER to cytosol;GO:0035617,stress granule disassembly;GO:0019985,translesion synthesis;GO:0055085,transmembrane transport;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0019079,viral genome replication	hsa:7415,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:7415,path:hsa05134,Legionellosis
MLEC_HUMAN	Q14165	MLEC	Malectin	1.442154	1.362576596	2.058128966	1.159992441	1.402365298	1.6090607035	1.402365298	1.6090607035	0.871542816843143	0.479279	0	1.1473905592179	0.479183	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0035579,specific granule membrane	GO:0030246,carbohydrate binding;GO:0019899,enzyme binding	GO:0005975,carbohydrate metabolic process;GO:0043312,neutrophil degranulation;GO:0006457,protein folding	
DNMT1_HUMAN	P26358	DNMT1	DNA (cytosine-5)-methyltransferase 1	0.095095669	0.068529753	0.102031313	0.090324007	0.081812711	0.09617766	0.081812711	0.09617766	0.850641521118314	0.487434	0	1.17558333936642	0.487356	0	GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003886,DNA (cytosine-5-)-methyltransferase activity;GO:0003677,DNA binding;GO:0009008,DNA-methyltransferase activity;GO:1990841,promoter-specific chromatin binding;GO:0008270,zinc ion binding;GO:0008168,methyltransferase activity	GO:0006325,chromatin organization;GO:0006306,DNA methylation;GO:0010216,maintenance of DNA methylation;GO:0010629,negative regulation of gene expression;GO:0045814,negative regulation of gene expression, epigenetic;GO:0051573,negative regulation of histone H3-K9 methylation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:1905460,negative regulation of vascular associated smooth muscle cell apoptotic process;GO:1905931,negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching;GO:0090309,positive regulation of DNA methylation-dependent heterochromatin assembly;GO:0010628,positive regulation of gene expression;GO:0051571,positive regulation of histone H3-K4 methylation;GO:1904707,positive regulation of vascular associated smooth muscle cell proliferation;GO:0007265,Ras protein signal transduction;GO:0032259,methylation	hsa:1786,path:hsa00270,Cysteine and methionine metabolism;hsa:1786,path:hsa05206,MicroRNAs in cancer
SPIT1_HUMAN	O43278	SPINT1	Kunitz-type protease inhibitor 1	0.224265096	0.175570168	0.18192501	0.152293346	0.199917632	0.167109178	0.199917632	0.167109178	1.19632945594407	0.374887	0	0.835890142996492	0.374569	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0004867,serine-type endopeptidase inhibitor activity	GO:0060670,branching involved in labyrinthine layer morphogenesis;GO:0071773,cellular response to BMP stimulus;GO:0030198,extracellular matrix organization;GO:2000178,negative regulation of neural precursor cell proliferation;GO:0001843,neural tube closure;GO:0060674,placenta blood vessel development;GO:0045687,positive regulation of glial cell differentiation	hsa:6692,path:hsa05202,Transcriptional misregulation in cancer;hsa:6692,path:hsa05215,Prostate cancer
MOT4_HUMAN	O15427	SLC16A3	Monocarboxylate transporter 4	0.490182761	0.336418108	0.291926897	0.224778099	0.4133004345	0.258352498	0.4133004345	0.258352498	1.59975397063898	0.286422	0	0.625096119999361	0.285951	0	GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0099061,integral component of postsynaptic density membrane;GO:0016328,lateral plasma membrane;GO:0016020,membrane;GO:0031965,nuclear membrane;GO:0098688,parallel fiber to Purkinje cell synapse;GO:0005886,plasma membrane	GO:0015129,lactate transmembrane transporter activity;GO:0008028,monocarboxylic acid transmembrane transporter activity;GO:0003723,RNA binding;GO:0015293,symporter activity	GO:0050900,leukocyte migration;GO:0015718,monocarboxylic acid transport;GO:0035879,plasma membrane lactate transport;GO:0006090,pyruvate metabolic process	hsa:9123,path:hsa05230,Central carbon metabolism in cancer
PGLT1_HUMAN	Q8NBL1	POGLUT1	Protein O-glucosyltransferase 1	0.093910566	0.116061192	0.159344751	0.128516138	0.104985879	0.1439304445	0.104985879	0.1439304445	0.729420932205903	0.429429	0	1.37095051135401	0.429598	0	GO:0012505,endomembrane system;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen	GO:0140561,EGF-domain serine glucosyltransferase activity;GO:0140562,EGF-domain serine xylosyltransferase activity;GO:0046527,glucosyltransferase activity;GO:0035251,UDP-glucosyltransferase activity;GO:0035252,UDP-xylosyltransferase activity;GO:0016757,transferase activity, transferring glycosyl groups	GO:0048318,axial mesoderm development;GO:0072359,circulatory system development;GO:0007369,gastrulation;GO:0060537,muscle tissue development;GO:0048339,paraxial mesoderm development;GO:0045747,positive regulation of Notch signaling pathway;GO:0006493,protein O-linked glycosylation;GO:0018242,protein O-linked glycosylation via serine;GO:0010470,regulation of gastrulation;GO:0001756,somitogenesis;GO:0006486,protein glycosylation	hsa:56983,path:hsa00514,Other types of O-glycan biosynthesis
DBNL_HUMAN	Q9UJU6	DBNL	Drebrin-like protein	1.52628389	2.712797517	2.188884135	1.204640919	2.1195407035	1.696762527	2.1195407035	1.696762527	1.24916755867275	0.361157	0	0.800533117480657	0.360813	0	GO:0005938,cell cortex;GO:0030665,clathrin-coated vesicle membrane;GO:0030864,cortical actin cytoskeleton;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0005769,early endosome;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0000139,Golgi membrane;GO:0030027,lamellipodium;GO:0043204,perikaryon;GO:0005886,plasma membrane;GO:0002102,podosome;GO:0014069,postsynaptic density;GO:0045211,postsynaptic membrane;GO:0001726,ruffle;GO:0034774,secretory granule lumen;GO:0030427,site of polarized growth;GO:1904724,tertiary granule lumen;GO:0005856,cytoskeleton;GO:0042995,cell projection;GO:0005768,endosome;GO:0045202,synapse	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0045296,cadherin binding;GO:0008047,enzyme activator activity;GO:0008022,protein C-terminus binding;GO:0019904,protein domain specific binding	GO:0007257,activation of JUN kinase activity;GO:0002250,adaptive immune response;GO:0048812,neuron projection morphogenesis;GO:0043312,neutrophil degranulation;GO:0071800,podosome assembly;GO:0045773,positive regulation of axon extension;GO:0061003,positive regulation of dendritic spine morphogenesis;GO:0098974,postsynaptic actin cytoskeleton organization;GO:0016601,Rac protein signal transduction;GO:0006898,receptor-mediated endocytosis;GO:0030833,regulation of actin filament polymerization;GO:0097178,ruffle assembly;GO:0007416,synapse assembly	
VATB2_HUMAN	P21281	ATP6V1B2	V-type proton ATPase subunit B, brain isoform	5.42096668	5.860445	7.824966054	6.013368183	5.64070584	6.9191671185	5.64070584	6.9191671185	0.815229021556404	0.496863	0	1.22664916674683	0.496957	0	GO:0016324,apical plasma membrane;GO:0005829,cytosol;GO:0012505,endomembrane system;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005765,lysosomal membrane;GO:0042470,melanosome;GO:0005902,microvillus;GO:0005886,plasma membrane;GO:0033180,proton-transporting V-type ATPase, V1 domain;GO:0001726,ruffle	GO:0005524,ATP binding;GO:0015078,proton transmembrane transporter activity;GO:0046961,proton-transporting ATPase activity, rotational mechanism	GO:0046034,ATP metabolic process;GO:0034198,cellular response to amino acid starvation;GO:0008286,insulin receptor signaling pathway;GO:0034220,ion transmembrane transport;GO:0090383,phagosome acidification;GO:1902600,proton transmembrane transport;GO:0016241,regulation of macroautophagy;GO:0033572,transferrin transport	hsa:526,path:hsa00190,Oxidative phosphorylation;hsa:526,path:hsa04150,mTOR signaling pathway;hsa:526,path:hsa04145,Phagosome;hsa:526,path:hsa04966,Collecting duct acid secretion;hsa:526,path:hsa04721,Synaptic vesicle cycle;hsa:526,path:hsa05323,Rheumatoid arthritis;hsa:526,path:hsa05110,Vibrio cholerae infection;hsa:526,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:526,path:hsa05165,Human papillomavirus infection
SAHH2_HUMAN	O43865	AHCYL1	S-adenosylhomocysteine hydrolase-like protein 1	1.000041368	1.62123432	1.396481191	4.756444104	1.310637844	3.0764626475	1.310637844	3.0764626475	0.426021048903374	0.158741	0	2.34730185884973	0.159074	0	GO:0016324,apical plasma membrane;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0044233,mitochondria-associated endoplasmic reticulum membrane	GO:0042802,identical protein binding;GO:0003723,RNA binding	GO:0038166,angiotensin-activated signaling pathway;GO:0006915,apoptotic process;GO:0042045,epithelial fluid transport;GO:1990456,mitochondrion-endoplasmic reticulum membrane tethering;GO:0006378,mRNA polyadenylation;GO:0006730,one-carbon metabolic process;GO:0010765,positive regulation of sodium ion transport;GO:0006611,protein export from nucleus;GO:0044070,regulation of anion transport;GO:1903779,regulation of cardiac conduction;GO:0032412,regulation of ion transmembrane transporter activity;GO:0031440,regulation of mRNA 3'-end processing;GO:0051592,response to calcium ion;GO:0033353,S-adenosylmethionine cycle	hsa:10768,path:hsa00270,Cysteine and methionine metabolism
SCYL2_HUMAN	Q6P3W7	SCYL2	SCY1-like protein 2	0.069919721	0.043412265	0.083729471	0.04766967	0.056665993	0.0656995705	0.056665993	0.0656995705	0.862501726704591	0.482781	0	1.15941796872773	0.482693	0	GO:0030136,clathrin-coated vesicle;GO:0010008,endosome membrane;GO:0005794,Golgi apparatus	GO:0005524,ATP binding;GO:0004672,protein kinase activity;GO:0005102,signaling receptor binding	GO:0007420,brain development;GO:0008333,endosome to lysosome transport;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:2000370,positive regulation of clathrin-dependent endocytosis;GO:0002092,positive regulation of receptor internalization;GO:0021860,pyramidal neuron development;GO:2000286,receptor internalization involved in canonical Wnt signaling pathway	
EP15R_HUMAN	Q9UBC2	EPS15L1	Epidermal growth factor receptor substrate 15-like 1	0.390058949	0.287951499	0.52140358	2.174953337	0.339005224	1.3481784585	0.339005224	1.3481784585	0.251454265466592	0.035509	-1	3.97686632256735	0.035689	1	GO:0030132,clathrin coat of coated pit;GO:0005829,cytosol;GO:0016020,membrane;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0045296,cadherin binding;GO:0005509,calcium ion binding	GO:0006897,endocytosis;GO:0016197,endosomal transport;GO:0061024,membrane organization;GO:0042059,negative regulation of epidermal growth factor receptor signaling pathway	hsa:58513,path:hsa04144,Endocytosis
NICA_HUMAN	Q92542	NCSTN	Nicastrin	1.268584772	1.348043206	1.061438569	1.034166467	1.308313989	1.047802518	1.308313989	1.047802518	1.24862649833792	0.361294	0	0.800880008017708	0.360950	0	GO:0035577,azurophil granule membrane;GO:0005769,early endosome;GO:0005783,endoplasmic reticulum;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0070765,gamma-secretase complex;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0099056,integral component of presynaptic membrane;GO:0005765,lysosomal membrane;GO:0042470,melanosome;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005886,plasma membrane;GO:0042383,sarcolemma;GO:0008021,synaptic vesicle	GO:0051117,ATPase binding;GO:0004175,endopeptidase activity;GO:0070851,growth factor receptor binding;GO:0030674,protein-macromolecule adaptor activity	GO:0030534,adult behavior;GO:1990000,amyloid fibril formation;GO:0042983,amyloid precursor protein biosynthetic process;GO:0042987,amyloid precursor protein catabolic process;GO:0042982,amyloid precursor protein metabolic process;GO:0034205,amyloid-beta formation;GO:0071277,cellular response to calcium ion;GO:0022010,central nervous system myelination;GO:0021549,cerebellum development;GO:0007212,dopamine receptor signaling pathway;GO:0048013,ephrin receptor signaling pathway;GO:0050673,epithelial cell proliferation;GO:0007215,glutamate receptor signaling pathway;GO:0007611,learning or memory;GO:0006509,membrane protein ectodomain proteolysis;GO:0031293,membrane protein intracellular domain proteolysis;GO:0002262,myeloid cell homeostasis;GO:0051402,neuron apoptotic process;GO:0043312,neutrophil degranulation;GO:0007220,Notch receptor processing;GO:0035333,Notch receptor processing, ligand-dependent;GO:0042986,positive regulation of amyloid precursor protein biosynthetic process;GO:0043065,positive regulation of apoptotic process;GO:0043085,positive regulation of catalytic activity;GO:0010950,positive regulation of endopeptidase activity;GO:0016485,protein processing;GO:0006508,proteolysis;GO:1900271,regulation of long-term synaptic potentiation;GO:1990926,short-term synaptic potentiation;GO:0042098,T cell proliferation	hsa:23385,path:hsa04330,Notch signaling pathway;hsa:23385,path:hsa05010,Alzheimer disease
ARPC3_HUMAN	O15145	ARPC3	Actin-related protein 2/3 complex subunit 3	5.531317471	20.00178129	0.907259564	0.379155037	12.7665493805	0.6432073005	12.7665493805	0.6432073005	19.8482656689	0.003611	1	0.0503822357419816	0.003545	-1	GO:0015629,actin cytoskeleton;GO:0005885,Arp2/3 protein complex;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0031941,filamentous actin;GO:0005925,focal adhesion;GO:0061850,growth cone leading edge;GO:0030027,lamellipodium;GO:0016020,membrane;GO:0005634,nucleus;GO:0035861,site of double-strand break;GO:0005737,cytoplasm	GO:0003779,actin binding;GO:0005200,structural constituent of cytoskeleton	GO:0070358,actin polymerization-dependent cell motility;GO:0034314,Arp2/3 complex-mediated actin nucleation;GO:1990090,cellular response to nerve growth factor stimulus;GO:0048013,ephrin receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0061024,membrane organization	hsa:10094,path:hsa04144,Endocytosis;hsa:10094,path:hsa04810,Regulation of actin cytoskeleton;hsa:10094,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:10094,path:hsa05130,Pathogenic Escherichia coli infection;hsa:10094,path:hsa05132,Salmonella infection;hsa:10094,path:hsa05131,Shigellosis;hsa:10094,path:hsa05100,Bacterial invasion of epithelial cells
PIPNA_HUMAN	Q00169	PITPNA	Phosphatidylinositol transfer protein alpha isoform	0.517849884	0.644421954	0.614061918	0.450706679	0.581135919	0.5323842985	0.581135919	0.5323842985	1.09157223576533	0.404507	0	0.916109779302766	0.404249	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0031210,phosphatidylcholine binding;GO:0120019,phosphatidylcholine transfer activity;GO:0008525,phosphatidylcholine transporter activity;GO:1901611,phosphatidylglycerol binding;GO:0035091,phosphatidylinositol binding;GO:0008526,phosphatidylinositol transfer activity;GO:0005548,phospholipid transporter activity	GO:0035722,interleukin-12-mediated signaling pathway;GO:0006629,lipid metabolic process;GO:0015914,phospholipid transport;GO:0007601,visual perception	
TBB3_HUMAN	Q13509	TUBB3	Tubulin beta-3 chain	4.806138366	3.620387202	6.077836811	2.910018259	4.213262784	4.493927535	4.213262784	4.493927535	0.937545777315254	0.454820	0	1.06661458479776	0.454670	0	GO:0030424,axon;GO:0005737,cytoplasm;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:0030175,filopodium;GO:0030426,growth cone;GO:0030027,lamellipodium;GO:0005874,microtubule;GO:0005634,nucleus	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:1990890,netrin receptor binding;GO:0005200,structural constituent of cytoskeleton	GO:0007411,axon guidance;GO:1990791,dorsal root ganglion development;GO:0000226,microtubule cytoskeleton organization;GO:0000278,mitotic cell cycle;GO:0007017,microtubule-based process	hsa:10381,path:hsa04145,Phagosome;hsa:10381,path:hsa04540,Gap junction;hsa:10381,path:hsa05130,Pathogenic Escherichia coli infection
RETST_HUMAN	Q6NUM9	RETSAT	All-trans-retinol 13,14-reductase	0.032869675	0.138317472	0.199849041	0.009783114	0.0855935735	0.1048160775	0.0855935735	0.1048160775	0.816607294811237	0.497893	0	1.22457882308185	0.497986	0	GO:0005789,endoplasmic reticulum membrane;GO:0016020,membrane;GO:0031965,nuclear membrane;GO:0005640,nuclear outer membrane	GO:0051786,all-trans-retinol 13,14-reductase activity	GO:0042572,retinol metabolic process	hsa:54884,path:hsa00830,Retinol metabolism
G3BP1_HUMAN	Q13283	G3BP1	Ras GTPase-activating protein-binding protein 1	0.926001245	0.688299026	1.424332192	0.800958278	0.8071501355	1.112645235	0.8071501355	1.112645235	0.725433507563622	0.426142	0	1.37848609083211	0.426315	0	GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005634,nucleus;GO:0043204,perikaryon;GO:1990904,ribonucleoprotein complex	GO:0005524,ATP binding;GO:0003677,DNA binding;GO:0003678,DNA helicase activity;GO:0033677,DNA/RNA helicase activity;GO:0004519,endonuclease activity;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity	GO:0051607,defense response to virus;GO:0045087,innate immune response;GO:0062029,positive regulation of stress granule assembly;GO:0032481,positive regulation of type I interferon production;GO:0007265,Ras protein signal transduction;GO:0034063,stress granule assembly;GO:0016032,viral process	
SORT_HUMAN	Q99523	SORT1	Sortilin	0.412257037	0.198706914	0.140836506	0.437348873	0.3054819755	0.2890926895	0.3054819755	0.2890926895	1.05669214959516	0.415146	0	0.94634941726701	0.414910	0	GO:0009986,cell surface;GO:0005905,clathrin-coated pit;GO:0030136,clathrin-coated vesicle;GO:0031410,cytoplasmic vesicle;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0030425,dendrite;GO:0005769,early endosome;GO:0005789,endoplasmic reticulum membrane;GO:0010008,endosome membrane;GO:0005794,Golgi apparatus;GO:0032580,Golgi cisterna membrane;GO:0016021,integral component of membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0043025,neuronal cell body;GO:0031965,nuclear membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0030140,trans-Golgi network transport vesicle	GO:0019899,enzyme binding;GO:0048406,nerve growth factor binding;GO:0010465,nerve growth factor receptor activity;GO:0030379,neurotensin receptor activity, non-G protein-coupled;GO:1905394,retromer complex binding	GO:0006897,endocytosis;GO:0008333,endosome to lysosome transport;GO:0032509,endosome transport via multivesicular body sorting pathway;GO:0008625,extrinsic apoptotic signaling pathway via death domain receptors;GO:0007186,G protein-coupled receptor signaling pathway;GO:0046323,glucose import;GO:0006895,Golgi to endosome transport;GO:0090160,Golgi to lysosome transport;GO:0007275,multicellular organism development;GO:0014902,myotube differentiation;GO:0045599,negative regulation of fat cell differentiation;GO:0051005,negative regulation of lipoprotein lipase activity;GO:0007218,neuropeptide signaling pathway;GO:0048011,neurotrophin TRK receptor signaling pathway;GO:0001503,ossification;GO:0048227,plasma membrane to endosome transport;GO:1904037,positive regulation of epithelial cell apoptotic process;GO:0006892,post-Golgi vesicle-mediated transport;GO:0006622,protein targeting to lysosome;GO:0010468,regulation of gene expression;GO:0032868,response to insulin;GO:0016050,vesicle organization	hsa:6272,path:hsa04142,Lysosome;hsa:6272,path:hsa04979,Cholesterol metabolism;hsa:6272,path:hsa04722,Neurotrophin signaling pathway
LDH6A_HUMAN	Q6ZMR3	LDHAL6A	L-lactate dehydrogenase A-like 6A	0.369831429	0.301978612	0.198048392	0.257390073	0.3359050205	0.2277192325	0.3359050205	0.2277192325	1.47508410603834	0.310130	0	0.677927445564929	0.309695	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome	GO:0004459,L-lactate dehydrogenase activity	GO:0005975,carbohydrate metabolic process;GO:0019752,carboxylic acid metabolic process	hsa:160287,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:160287,path:hsa00620,Pyruvate metabolism;hsa:160287,path:hsa00640,Propanoate metabolism;hsa:160287,path:hsa00270,Cysteine and methionine metabolism;hsa:160287,path:hsa04066,HIF-1 signaling pathway;hsa:160287,path:hsa04922,Glucagon signaling pathway;hsa:160287,path:hsa05230,Central carbon metabolism in cancer
NU133_HUMAN	Q8WUM0	NUP133	Nuclear pore complex protein Nup133	0.157206933	0.097901794	0.242551794	0.145444495	0.1275543635	0.1939981445	0.1275543635	0.1939981445	0.657503007715623	0.368262	0	1.52090559018783	0.368494	0	GO:0000777,condensed chromosome kinetochore;GO:0005829,cytosol;GO:0043657,host cell;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0005643,nuclear pore;GO:0031080,nuclear pore outer ring	GO:0017056,structural constituent of nuclear pore	GO:0075733,intracellular transport of virus;GO:0007084,mitotic nuclear envelope reassembly;GO:0007052,mitotic spindle organization;GO:0006406,mRNA export from nucleus;GO:0072006,nephron development;GO:0021915,neural tube development;GO:0022008,neurogenesis;GO:0006999,nuclear pore organization;GO:0048339,paraxial mesoderm development;GO:0016973,poly(A)+ mRNA export from nucleus;GO:0006606,protein import into nucleus;GO:0016925,protein sumoylation;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0061053,somite development;GO:0000972,transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription	hsa:55746,path:hsa03013,RNA transport
HSP13_HUMAN	P48723	HSPA13	Heat shock 70 kDa protein 13	0.28100593	0.1133843	0.44184362	0.094038093	0.197195115	0.2679408565	0.197195115	0.2679408565	0.735965084145351	0.434795	0	1.35876011178066	0.434959	0	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0031072,heat shock protein binding;GO:0051787,misfolded protein binding;GO:0044183,protein folding chaperone;GO:0051082,unfolded protein binding	GO:0034620,cellular response to unfolded protein;GO:0051085,chaperone cofactor-dependent protein refolding;GO:0042026,protein refolding	
ARL2_HUMAN	P36404	ARL2	ADP-ribosylation factor-like protein 2	0.172379926	0.524527759	0.015485964	0.003388544	0.3484538425	0.009437254	0.3484538425	0.009437254	36.9232239060218	0.000665	1	0.0270832255207517	0.000648	-1	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0016328,lateral plasma membrane;GO:0015630,microtubule cytoskeleton;GO:0005758,mitochondrial intermembrane space;GO:0005759,mitochondrial matrix;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0005095,GTPase inhibitor activity	GO:0070830,bicellular tight junction assembly;GO:0007098,centrosome cycle;GO:0051457,maintenance of protein location in nucleus;GO:0000165,MAPK cascade;GO:0034260,negative regulation of GTPase activity;GO:0010811,positive regulation of cell-substrate adhesion;GO:0031116,positive regulation of microtubule polymerization;GO:0031113,regulation of microtubule polymerization;GO:0007021,tubulin complex assembly	
DNJC7_HUMAN	Q99615	DNAJC7	DnaJ homolog subfamily C member 7	0.137547788	0.100549173	0.242675801	0.28623145	0.1190484805	0.2644536255	0.1190484805	0.2644536255	0.450167700574784	0.179993	0	2.22139437974599	0.180329	0	GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005654,nucleoplasm	GO:0031072,heat shock protein binding	GO:0051085,chaperone cofactor-dependent protein refolding;GO:0006457,protein folding;GO:1900034,regulation of cellular response to heat	
CPNE2_HUMAN	Q96FN4	CPNE2	Copine-2	0.270265239	0.227339104	0.332845821	0.253657212	0.2488021715	0.2932515165	0.2488021715	0.2932515165	0.848425864832655	0.488311	0	1.17865336436583	0.488234	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0005544,calcium-dependent phospholipid binding;GO:0046872,metal ion binding	GO:0071277,cellular response to calcium ion	
TYDP2_HUMAN	O95551	TDP2	Tyrosyl-DNA phosphodiesterase 2	0.064308444	0.01081732	0.026353615	2.55E-05	0.037562882	0.0131895575	0.037562882	0.0131895575	2.84792586862751	0.146863	0	0.351132735235811	0.146296	0	GO:0016235,aggresome;GO:0005737,cytoplasm;GO:0016604,nuclear body;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016605,PML body	GO:0070260,5'-tyrosyl-DNA phosphodiesterase activity;GO:0000287,magnesium ion binding;GO:0030145,manganese ion binding;GO:0004518,nuclease activity;GO:0003697,single-stranded DNA binding;GO:0003714,transcription corepressor activity;GO:0036317,tyrosyl-RNA phosphodiesterase activity	GO:0007166,cell surface receptor signaling pathway;GO:0006302,double-strand break repair;GO:0048666,neuron development;GO:0016032,viral process	
BAG5_HUMAN	Q9UL15	BAG5	BAG family molecular chaperone regulator 5	0.023973762	0.046614995	0.051720872	2.55E-05	0.0352943785	0.025873186	0.0352943785	0.025873186	1.36412958574178	0.333754	0	0.733068185348553	0.333359	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016234,inclusion body;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm	GO:0000774,adenyl-nucleotide exchange factor activity;GO:0051087,chaperone binding;GO:0031072,heat shock protein binding;GO:0019901,protein kinase binding;GO:0031625,ubiquitin protein ligase binding	GO:0007030,Golgi organization;GO:0010977,negative regulation of neuron projection development;GO:1902176,negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:0032435,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0061084,negative regulation of protein refolding;GO:0031397,negative regulation of protein ubiquitination;GO:0051444,negative regulation of ubiquitin-protein transferase activity;GO:0070997,neuron death;GO:0006457,protein folding;GO:0050821,protein stabilization;GO:1900034,regulation of cellular response to heat;GO:0090083,regulation of inclusion body assembly;GO:0051438,regulation of ubiquitin-protein transferase activity	
TBCD4_HUMAN	O60343	TBC1D4	TBC1 domain family member 4	7.370165838	2.649915274	10.10052714	3.794094486	5.010040556	6.947310813	5.010040556	6.947310813	0.721148181052311	0.422595	0	1.38667755986125	0.422772	0	GO:0005829,cytosol;GO:0031982,vesicle	GO:0005096,GTPase activator activity	GO:0090630,activation of GTPase activity;GO:0032869,cellular response to insulin stimulus;GO:0006886,intracellular protein transport;GO:0031339,negative regulation of vesicle fusion;GO:0016192,vesicle-mediated transport;GO:0043547,positive regulation of GTPase activity	hsa:9882,path:hsa04919,Thyroid hormone signaling pathway;hsa:9882,path:hsa04931,Insulin resistance
SYFB_HUMAN	Q9NSD9	FARSB	Phenylalanine--tRNA ligase beta subunit	3.28026556	2.096040929	3.662589164	2.578576279	2.6881532445	3.1205827215	2.6881532445	3.1205827215	0.861426689950991	0.483200	0	1.16086489037958	0.483113	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0009328,phenylalanine-tRNA ligase complex	GO:0005524,ATP binding;GO:0000287,magnesium ion binding;GO:0004826,phenylalanine-tRNA ligase activity;GO:0003723,RNA binding	GO:0006432,phenylalanyl-tRNA aminoacylation;GO:0051290,protein heterotetramerization;GO:0006412,translation;GO:0006418,tRNA aminoacylation for protein translation	hsa:10056,path:hsa00970,Aminoacyl-tRNA biosynthesis
HDHD5_HUMAN	Q9BXW7	HDHD5	Haloacid dehalogenase-like hydrolase domain-containing 5	0.621150125	0.104004308	0.625296062	0.134099054	0.3625772165	0.379697558	0.3625772165	0.379697558	0.954910583069908	0.448694	0	1.04721847022067	0.448531	0	GO:0005739,mitochondrion		GO:0046474,glycerophospholipid biosynthetic process	
HCFC1_HUMAN	P51610	HCFC1	Host cell factor 1	1.26305749	1.473735302	1.407869887	1.194522283	1.368396396	1.301196085	1.368396396	1.301196085	1.05164503011858	0.416720	0	0.950891195565528	0.416488	0	GO:0005737,cytoplasm;GO:0000123,histone acetyltransferase complex;GO:0035097,histone methyltransferase complex;GO:0016020,membrane;GO:0071339,MLL1 complex;GO:0043025,neuronal cell body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0048188,Set1C/COMPASS complex;GO:0030424,axon;GO:0030425,dendrite	GO:0033613,activating transcription factor binding;GO:0045296,cadherin binding;GO:0003682,chromatin binding;GO:0042802,identical protein binding;GO:0030674,protein-macromolecule adaptor activity;GO:0003713,transcription coactivator activity	GO:0007049,cell cycle;GO:0006338,chromatin remodeling;GO:0043984,histone H4-K16 acetylation;GO:0043981,histone H4-K5 acetylation;GO:0043982,histone H4-K8 acetylation;GO:0007005,mitochondrion organization;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045787,positive regulation of cell cycle;GO:0010628,positive regulation of gene expression;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0016579,protein deubiquitination;GO:0050821,protein stabilization;GO:0043254,regulation of protein-containing complex assembly;GO:0006355,regulation of transcription, DNA-templated;GO:0019046,release from viral latency;GO:0071407,cellular response to organic cyclic compound	hsa:3054,path:hsa05168,Herpes simplex virus 1 infection
SRPRB_HUMAN	Q9Y5M8	SRPRB	Signal recognition particle receptor subunit beta	1.925611709	1.697878932	2.244844353	0.21915853	1.8117453205	1.2320014415	1.8117453205	1.2320014415	1.47057077976641	0.311042	0	0.680008071531818	0.310609	0	GO:0005737,cytoplasm;GO:0005881,cytoplasmic microtubule;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005785,signal recognition particle receptor complex	GO:0005525,GTP binding	GO:0036498,IRE1-mediated unfolded protein response;GO:0045047,protein targeting to ER	hsa:58477,path:hsa03060,Protein export
PYC_HUMAN	P11498	PC	Pyruvate carboxylase, mitochondrial	2.414005093	3.967154084	2.720912334	2.570599733	3.1905795885	2.6457560335	3.1905795885	2.6457560335	1.20592358029295	0.372337	0	0.829239942183627	0.372014	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0009374,biotin binding;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0004736,pyruvate carboxylase activity;GO:0003824,catalytic activity	GO:0006768,biotin metabolic process;GO:0006094,gluconeogenesis;GO:0006629,lipid metabolic process;GO:0010629,negative regulation of gene expression;GO:0044794,positive regulation by host of viral process;GO:0044791,positive regulation by host of viral release from host cell;GO:0006090,pyruvate metabolic process;GO:0019074,viral RNA genome packaging	hsa:5091,path:hsa00020,Citrate cycle (TCA cycle);hsa:5091,path:hsa00620,Pyruvate metabolism
IGHA1_HUMAN	P01876	IGHA1	Immunoglobulin heavy constant alpha 1	37.34892733	25.51408848	71.67249731	148.1534137	31.431507905	109.912955505	31.431507905	109.912955505	0.285967270742439	0.053829	0	3.49690367503862	0.054056	0	GO:0072562,blood microparticle;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0042571,immunoglobulin complex, circulating;GO:0071748,monomeric IgA immunoglobulin complex;GO:0071752,secretory dimeric IgA immunoglobulin complex;GO:0071751,secretory IgA immunoglobulin complex	GO:0003823,antigen binding	GO:0019731,antibacterial humoral response;GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0003094,glomerular filtration;GO:0006955,immune response;GO:0045087,innate immune response;GO:0050900,leukocyte migration;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0060267,positive regulation of respiratory burst;GO:0018298,protein-chromophore linkage;GO:0006898,receptor-mediated endocytosis;GO:0001895,retina homeostasis	
LYAG_HUMAN	P10253	GAA	Lysosomal alpha-glucosidase	1.455352143	6.803493219	2.016831262	1.579554885	4.129422681	1.7981930735	4.129422681	1.7981930735	2.29642897743038	0.192542	0	0.435458709948419	0.191977	0	GO:0035577,azurophil granule membrane;GO:0070062,extracellular exosome;GO:0101003,ficolin-1-rich granule membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0043202,lysosomal lumen;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0070821,tertiary granule membrane;GO:0016021,integral component of membrane	GO:0004558,alpha-1,4-glucosidase activity;GO:0030246,carbohydrate binding;GO:0004553,hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0032450,maltose alpha-glucosidase activity;GO:0003824,catalytic activity	GO:0060048,cardiac muscle contraction;GO:0002086,diaphragm contraction;GO:0006006,glucose metabolic process;GO:0005980,glycogen catabolic process;GO:0003007,heart morphogenesis;GO:0007626,locomotory behavior;GO:0007040,lysosome organization;GO:0000023,maltose metabolic process;GO:0046716,muscle cell cellular homeostasis;GO:0050885,neuromuscular process controlling balance;GO:0050884,neuromuscular process controlling posture;GO:0043312,neutrophil degranulation;GO:0002026,regulation of the force of heart contraction;GO:0005985,sucrose metabolic process;GO:0009888,tissue development;GO:0043181,vacuolar sequestering;GO:0005975,carbohydrate metabolic process	hsa:2548,path:hsa00052,Galactose metabolism;hsa:2548,path:hsa00500,Starch and sucrose metabolism;hsa:2548,path:hsa04142,Lysosome
NUBP2_HUMAN	Q9Y5Y2	NUBP2	Cytosolic Fe-S cluster assembly factor NUBP2	0.867454483	0.103543675	0.547391911	0.366003268	0.485499079	0.4566975895	0.485499079	0.4566975895	1.0630646847327	0.413171	0	0.940676531128909	0.412932	0	GO:0005814,centriole;GO:0005929,cilium;GO:0005829,cytosol;GO:0005634,nucleus;GO:0031616,spindle pole centrosome	GO:0051539,4 iron, 4 sulfur cluster binding;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0051536,iron-sulfur cluster binding;GO:0046872,metal ion binding;GO:0000166,nucleotide binding	GO:0030030,cell projection organization;GO:0016226,iron-sulfur cluster assembly	
AMPD2_HUMAN	Q01433	AMPD2	AMP deaminase 2	0.22345657	0.322722084	0.333354864	0.081578129	0.273089327	0.2074664965	0.273089327	0.2074664965	1.31630567637218	0.344765	0	0.759701958253389	0.344391	0	GO:0005829,cytosol	GO:0003876,AMP deaminase activity;GO:0042802,identical protein binding;GO:0046872,metal ion binding	GO:0046033,AMP metabolic process;GO:0052652,cyclic purine nucleotide metabolic process;GO:0097009,energy homeostasis;GO:0006188,IMP biosynthetic process;GO:0032264,IMP salvage;GO:0043101,purine-containing compound salvage	hsa:271,path:hsa00230,Purine metabolism
PARVG_HUMAN	Q9HBI0	PARVG	Gamma-parvin	0.0904299	0.073717144	0.184279385	0.074147422	0.082073522	0.1292134035	0.082073522	0.1292134035	0.635178083518247	0.348546	0	1.57436162542166	0.348795	0	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005925,focal adhesion;GO:0005886,plasma membrane	GO:0003779,actin binding	GO:0031532,actin cytoskeleton reorganization;GO:0030031,cell projection assembly;GO:0007160,cell-matrix adhesion;GO:0007163,establishment or maintenance of cell polarity;GO:0034446,substrate adhesion-dependent cell spreading	hsa:64098,path:hsa04510,Focal adhesion
FKBP5_HUMAN	Q13451	FKBP5	Peptidyl-prolyl cis-trans isomerase FKBP5	0.882213694	0.358803618	1.116002578	0.459118261	0.620508656	0.7875604195	0.620508656	0.7875604195	0.787887050486798	0.476079	0	1.26921745874888	0.476197	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005654,nucleoplasm	GO:0005528,FK506 binding;GO:0031072,heat shock protein binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity	GO:0061077,chaperone-mediated protein folding;GO:0006457,protein folding;GO:0000413,protein peptidyl-prolyl isomerization;GO:0009617,response to bacterium	hsa:2289,path:hsa04915,Estrogen signaling pathway
GGH_HUMAN	Q92820	GGH	Gamma-glutamyl hydrolase	0.464681625	0.30101873	0.830842972	0.22585011	0.3828501775	0.528346541	0.3828501775	0.528346541	0.724619445365121	0.425469	0	1.38003472912064	0.425643	0	GO:0035578,azurophil granule lumen;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0042470,melanosome;GO:0005634,nucleus;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen;GO:0005773,vacuole	GO:0008238,exopeptidase activity;GO:0034722,gamma-glutamyl-peptidase activity;GO:0008242,omega peptidase activity	GO:0043312,neutrophil degranulation;GO:0070500,poly-gamma-glutamate metabolic process;GO:0042493,response to drug;GO:0045471,response to ethanol;GO:0032868,response to insulin;GO:0010043,response to zinc ion;GO:0046900,tetrahydrofolylpolyglutamate metabolic process	hsa:8836,path:hsa00790,Folate biosynthesis;hsa:8836,path:hsa01523,Antifolate resistance
SWP70_HUMAN	Q9UH65	SWAP70	Switch-associated protein 70	0.885673677	0.84191163	0.913647567	2.610265902	0.8637926535	1.7619567345	0.8637926535	1.7619567345	0.490246233966195	0.216211	0	2.03979129408051	0.216542	0	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0030027,lamellipodium;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0005509,calcium ion binding;GO:0003677,DNA binding	GO:0051017,actin filament bundle assembly;GO:0045190,isotype switching;GO:0030835,negative regulation of actin filament depolymerization;GO:0033633,negative regulation of cell-cell adhesion mediated by integrin;GO:1902309,negative regulation of peptidyl-serine dephosphorylation;GO:0032233,positive regulation of actin filament bundle assembly;GO:0007204,positive regulation of cytosolic calcium ion concentration;GO:0060754,positive regulation of mast cell chemotaxis;GO:0032880,regulation of protein localization	
PP2BA_HUMAN	Q08209	PPP3CA	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	1.998208701	2.017976548	2.708979054	3.222068956	2.0080926245	2.965524005	2.0080926245	2.965524005	0.677145968508186	0.385345	0	1.47678646334274	0.385560	0	GO:0005955,calcineurin complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0019897,extrinsic component of plasma membrane;GO:0098978,glutamatergic synapse;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0042383,sarcolemma;GO:0098685,Schaffer collateral - CA1 synapse;GO:0036057,slit diaphragm;GO:0030018,Z disc	GO:0051117,ATPase binding;GO:0005509,calcium ion binding;GO:0005516,calmodulin binding;GO:0033192,calmodulin-dependent protein phosphatase activity;GO:0016018,cyclosporin A binding;GO:0019899,enzyme binding;GO:0046983,protein dimerization activity;GO:0106306,protein serine phosphatase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0106307,protein threonine phosphatase activity;GO:0044877,protein-containing complex binding;GO:0046872,metal ion binding	GO:0007568,aging;GO:0007420,brain development;GO:0097720,calcineurin-mediated signaling;GO:0033173,calcineurin-NFAT signaling cascade;GO:0006816,calcium ion transport;GO:0014898,cardiac muscle hypertrophy in response to stress;GO:0071333,cellular response to glucose stimulus;GO:0016311,dephosphorylation;GO:0060079,excitatory postsynaptic potential;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0000082,G1/S transition of mitotic cell cycle;GO:0033555,multicellular organismal response to stress;GO:0035562,negative regulation of chromatin binding;GO:0050774,negative regulation of dendrite morphogenesis;GO:0046676,negative regulation of insulin secretion;GO:1903799,negative regulation of production of miRNAs involved in gene silencing by miRNA;GO:0070262,peptidyl-serine dephosphorylation;GO:1903244,positive regulation of cardiac muscle hypertrophy in response to stress;GO:0045785,positive regulation of cell adhesion;GO:0030335,positive regulation of cell migration;GO:1905205,positive regulation of connective tissue replacement;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0045807,positive regulation of endocytosis;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0099170,postsynaptic modulation of chemical synaptic transmission;GO:0006470,protein dephosphorylation;GO:0006606,protein import into nucleus;GO:0001975,response to amphetamine;GO:0051592,response to calcium ion;GO:0048741,skeletal muscle fiber development;GO:0043403,skeletal muscle tissue regeneration;GO:0042110,T cell activation;GO:0014883,transition between fast and slow fiber;GO:0007223,Wnt signaling pathway, calcium modulating pathway;GO:0042060,wound healing	hsa:5530,path:hsa04010,MAPK signaling pathway;hsa:5530,path:hsa04310,Wnt signaling pathway;hsa:5530,path:hsa04370,VEGF signaling pathway;hsa:5530,path:hsa04020,Calcium signaling pathway;hsa:5530,path:hsa04022,cGMP-PKG signaling pathway;hsa:5530,path:hsa04114,Oocyte meiosis;hsa:5530,path:hsa04218,Cellular senescence;hsa:5530,path:hsa04625,C-type lectin receptor signaling pathway;hsa:5530,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:5530,path:hsa04660,T cell receptor signaling pathway;hsa:5530,path:hsa04658,Th1 and Th2 cell differentiation;hsa:5530,path:hsa04659,Th17 cell differentiation;hsa:5530,path:hsa04662,B cell receptor signaling pathway;hsa:5530,path:hsa04922,Glucagon signaling pathway;hsa:5530,path:hsa04921,Oxytocin signaling pathway;hsa:5530,path:hsa04924,Renin secretion;hsa:5530,path:hsa04724,Glutamatergic synapse;hsa:5530,path:hsa04728,Dopaminergic synapse;hsa:5530,path:hsa04720,Long-term potentiation;hsa:5530,path:hsa04360,Axon guidance;hsa:5530,path:hsa04380,Osteoclast differentiation;hsa:5530,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:5530,path:hsa05010,Alzheimer disease;hsa:5530,path:hsa05014,Amyotrophic lateral sclerosis (ALS);hsa:5530,path:hsa05031,Amphetamine addiction;hsa:5530,path:hsa05152,Tuberculosis;hsa:5530,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:5530,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:5530,path:hsa05163,Human cytomegalovirus infection;hsa:5530,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection
SHLB1_HUMAN	Q9Y371	SH3GLB1	Endophilin-B1	0.891278231	0.613321791	0.88025154	0.996227858	0.752300011	0.938239699	0.752300011	0.938239699	0.801820698699725	0.486755	0	1.24716161807952	0.486861	0	GO:0000421,autophagosome membrane;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0000139,Golgi membrane;GO:0030496,midbody;GO:0005741,mitochondrial outer membrane;GO:0032991,protein-containing complex	GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0008289,lipid binding;GO:0042803,protein homodimerization activity	GO:0006915,apoptotic process;GO:0048102,autophagic cell death;GO:0006914,autophagy;GO:0034198,cellular response to amino acid starvation;GO:0042149,cellular response to glucose starvation;GO:0090148,membrane fission;GO:2000786,positive regulation of autophagosome assembly;GO:0010508,positive regulation of autophagy;GO:1903527,positive regulation of membrane tubulation;GO:1903955,positive regulation of protein targeting to mitochondrion;GO:0031334,positive regulation of protein-containing complex assembly;GO:1903778,protein localization to vacuolar membrane;GO:0032801,receptor catabolic process;GO:0032465,regulation of cytokinesis;GO:0016241,regulation of macroautophagy;GO:0031647,regulation of protein stability	hsa:51100,path:hsa04144,Endocytosis;hsa:51100,path:hsa04140,Autophagy - animal
NXN_HUMAN	Q6DKJ4	NXN	Nucleoredoxin	0.141637629	0.059375959	0.079139692	2.55E-05	0.100506794	0.039582596	0.100506794	0.039582596	2.53916630430202	0.170230	0	0.393830052921597	0.169659	0	GO:0005829,cytosol;GO:0005634,nucleus	GO:0047134,protein-disulfide reductase activity;GO:0004791,thioredoxin-disulfide reductase activity	GO:0030154,cell differentiation;GO:0072359,circulatory system development;GO:0001701,in utero embryonic development;GO:0031397,negative regulation of protein ubiquitination;GO:0030178,negative regulation of Wnt signaling pathway;GO:0016055,Wnt signaling pathway	
SMD3_HUMAN	P62318	SNRPD3	Small nuclear ribonucleoprotein Sm D3	5.631146672	7.967620324	1.73772598	0.755469812	6.799383498	1.246597896	6.799383498	1.246597896	5.45435181610478	0.055056	0	0.183339841967537	0.054646	0	GO:0071013,catalytic step 2 spliceosome;GO:0000243,commitment complex;GO:0005829,cytosol;GO:0034709,methylosome;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0034715,pICln-Sm protein complex;GO:0071011,precatalytic spliceosome;GO:0030532,small nuclear ribonucleoprotein complex;GO:0034719,SMN-Sm protein complex;GO:0005681,spliceosomal complex;GO:0097526,spliceosomal tri-snRNP complex;GO:0005697,telomerase holoenzyme complex;GO:0005685,U1 snRNP;GO:0005689,U12-type spliceosomal complex;GO:0005686,U2 snRNP;GO:0071007,U2-type catalytic step 2 spliceosome;GO:0071005,U2-type precatalytic spliceosome;GO:0005687,U4 snRNP;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005682,U5 snRNP;GO:0005683,U7 snRNP	GO:0019899,enzyme binding;GO:0071208,histone pre-mRNA DCP binding;GO:0003723,RNA binding;GO:0070034,telomerase RNA binding;GO:0071209,U7 snRNA binding	GO:0008334,histone mRNA metabolic process;GO:0051170,import into nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0006479,protein methylation;GO:0008380,RNA splicing;GO:0000387,spliceosomal snRNP assembly;GO:0006369,termination of RNA polymerase II transcription	hsa:6634,path:hsa03040,Spliceosome;hsa:6634,path:hsa05322,Systemic lupus erythematosus
KINH_HUMAN	P33176	KIF5B	Kinesin-1 heavy chain	5.874969423	3.606996859	5.491177496	5.257315495	4.740983141	5.3742464955	4.740983141	5.3742464955	0.882167043318492	0.475211	0	1.13357215912108	0.475106	0	GO:1904115,axon cytoplasm;GO:0044295,axonal growth cone;GO:0034451,centriolar satellite;GO:0035253,ciliary rootlet;GO:0005829,cytosol;GO:0032839,dendrite cytoplasm;GO:0005871,kinesin complex;GO:0016020,membrane;GO:0005874,microtubule;GO:0048471,perinuclear region of cytoplasm;GO:0045335,phagocytic vesicle;GO:0031982,vesicle	GO:0005524,ATP binding;GO:0008574,ATP-dependent microtubule motor activity, plus-end-directed;GO:0016887,ATPase activity;GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0008432,JUN kinase binding;GO:0008017,microtubule binding;GO:0099609,microtubule lateral binding;GO:0003777,microtubule motor activity	GO:0099641,anterograde axonal protein transport;GO:0098971,anterograde dendritic transport of neurotransmitter receptor complex;GO:1990048,anterograde neuronal dense core vesicle transport;GO:0007411,axon guidance;GO:0071346,cellular response to interferon-gamma;GO:0051642,centrosome localization;GO:0007028,cytoplasm organization;GO:0030705,cytoskeleton-dependent intracellular transport;GO:0021766,hippocampus development;GO:0032418,lysosome localization;GO:0007018,microtubule-based movement;GO:0042267,natural killer cell mediated cytotoxicity;GO:0072383,plus-end-directed vesicle transport along microtubule;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0090316,positive regulation of intracellular protein transport;GO:0043268,positive regulation of potassium ion transport;GO:1903078,positive regulation of protein localization to plasma membrane;GO:0032230,positive regulation of synaptic transmission, GABAergic;GO:0031340,positive regulation of vesicle fusion;GO:1905152,positive regulation of voltage-gated sodium channel activity;GO:0042391,regulation of membrane potential;GO:1990049,retrograde neuronal dense core vesicle transport;GO:0035617,stress granule disassembly;GO:0048489,synaptic vesicle transport;GO:0047496,vesicle transport along microtubule	hsa:3799,path:hsa04144,Endocytosis;hsa:3799,path:hsa04728,Dopaminergic synapse
CCAR2_HUMAN	Q8N163	CCAR2	Cell cycle and apoptosis regulator protein 2	1.386823237	0.602522666	1.375996854	1.572685959	0.9946729515	1.4743414065	0.9946729515	1.4743414065	0.674655779939936	0.383194	0	1.48223735678812	0.383411	0	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0044609,DBIRD complex;GO:0005759,mitochondrial matrix;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005819,spindle	GO:0019899,enzyme binding;GO:0004857,enzyme inhibitor activity;GO:0030374,nuclear receptor coactivator activity;GO:0003723,RNA binding;GO:0000993,RNA polymerase II complex binding	GO:0007049,cell cycle;GO:0006974,cellular response to DNA damage stimulus;GO:0043653,mitochondrial fragmentation involved in apoptotic process;GO:0006397,mRNA processing;GO:0043086,negative regulation of catalytic activity;GO:0030308,negative regulation of cell growth;GO:1902230,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0032435,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0045892,negative regulation of transcription, DNA-templated;GO:0043065,positive regulation of apoptotic process;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:2000003,positive regulation of DNA damage checkpoint;GO:1900034,regulation of cellular response to heat;GO:0042752,regulation of circadian rhythm;GO:0032784,regulation of DNA-templated transcription, elongation;GO:0090311,regulation of protein deacetylation;GO:0031647,regulation of protein stability;GO:0006355,regulation of transcription, DNA-templated;GO:0009411,response to UV;GO:0048511,rhythmic process;GO:0008380,RNA splicing;GO:0016055,Wnt signaling pathway	
FAD1_HUMAN	Q8NFF5	FLAD1	FAD synthase	0.20928504	0.213562664	0.357944568	1.292617881	0.211423852	0.8252812245	0.211423852	0.8252812245	0.256184008218643	0.037794	-1	3.90344427411151	0.037981	1	GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005886,plasma membrane	GO:0005524,ATP binding;GO:0003919,FMN adenylyltransferase activity;GO:0042802,identical protein binding;GO:0003824,catalytic activity	GO:0006747,FAD biosynthetic process;GO:0006771,riboflavin metabolic process	hsa:80308,path:hsa00740,Riboflavin metabolism
TRAM1_HUMAN	Q15629	TRAM1	Translocating chain-associated membrane protein 1	1.437762708	1.795280959	3.300156814	2.062101112	1.6165218335	2.681128963	1.6165218335	2.681128963	0.602925803200165	0.319575	0	1.65857887436941	0.319849	0	GO:0005783,endoplasmic reticulum;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016021,integral component of membrane	GO:0038023,signaling receptor activity	GO:0006613,cotranslational protein targeting to membrane;GO:0045048,protein insertion into ER membrane;GO:0006616,SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0016032,viral process	hsa:23471,path:hsa04141,Protein processing in endoplasmic reticulum
NUCB2_HUMAN	P80303	NUCB2	Nucleobindin-2	0.645616076	0.394384141	0.877440428	0.683652531	0.5200001085	0.7805464795	0.5200001085	0.7805464795	0.666200056187685	0.375858	0	1.5010506089154	0.376082	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005794,Golgi apparatus;GO:0005635,nuclear envelope;GO:0005886,plasma membrane	GO:0005509,calcium ion binding;GO:0003677,DNA binding;GO:0001965,G-protein alpha-subunit binding;GO:0005085,guanyl-nucleotide exchange factor activity	GO:0032099,negative regulation of appetite;GO:0007264,small GTPase mediated signal transduction	
FBXL8_HUMAN	Q96CD0	FBXL8	F-box/LRR-repeat protein 8	0.196099819	0.106921227	0.247728824	0.55070868	0.151510523	0.399218752	0.151510523	0.399218752	0.379517550818855	0.119740	0	2.63492425539314	0.120055	0	GO:0005829,cytosol;GO:0005634,nucleus;GO:0019005,SCF ubiquitin ligase complex		GO:0043153,entrainment of circadian clock by photoperiod;GO:0000086,G2/M transition of mitotic cell cycle;GO:0043687,post-translational protein modification;GO:0000209,protein polyubiquitination;GO:0051726,regulation of cell cycle;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	
K22E_HUMAN	P35908	KRT2	Keratin, type II cytoskeletal 2 epidermal	150.5682349	72.63379925	78.23893405	95.72111033	111.601017075	86.98002219	111.601017075	86.98002219	1.28306494140939	0.352740	0	0.779383776865996	0.352380	0	GO:0001533,cornified envelope;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005882,intermediate filament;GO:0045095,keratin filament;GO:0016020,membrane;GO:0005634,nucleus	GO:0008092,cytoskeletal protein binding;GO:0005200,structural constituent of cytoskeleton;GO:0030280,structural constituent of skin epidermis	GO:0070268,cornification;GO:0008544,epidermis development;GO:0045109,intermediate filament organization;GO:0031424,keratinization;GO:0032980,keratinocyte activation;GO:0003334,keratinocyte development;GO:0051546,keratinocyte migration;GO:0043616,keratinocyte proliferation;GO:0018149,peptide cross-linking;GO:0045684,positive regulation of epidermis development	
ZO2_HUMAN	Q9UDY2	TJP2	Tight junction protein ZO-2	0.276991759	0.295398937	0.349146172	0.467483831	0.286195348	0.4083150015	0.286195348	0.4083150015	0.700918033745082	0.405652	0	1.42670034419986	0.405847	0	GO:0005912,adherens junction;GO:0005923,bicellular tight junction;GO:0044291,cell-cell contact zone;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0045296,cadherin binding;GO:0050839,cell adhesion molecule binding;GO:0004385,guanylate kinase activity;GO:0019904,protein domain specific binding;GO:1990782,protein tyrosine kinase binding;GO:0030674,protein-macromolecule adaptor activity	GO:0098609,cell-cell adhesion;GO:0045216,cell-cell junction organization;GO:0090557,establishment of endothelial intestinal barrier;GO:0035329,hippo signaling;GO:0034109,homotypic cell-cell adhesion;GO:0050892,intestinal absorption;GO:0035633,maintenance of blood-brain barrier;GO:1905605,positive regulation of blood-brain barrier permeability;GO:0150105,protein localization to cell-cell junction;GO:0090559,regulation of membrane permeability	hsa:9414,path:hsa04530,Tight junction;hsa:9414,path:hsa05110,Vibrio cholerae infection
SPB3_HUMAN	P29508	SERPINB3	Serpin B3	2.562784603	2.151346064	2.248065428	7.026707987	2.3570653335	4.6373867075	2.3570653335	4.6373867075	0.508274483490441	0.232736	0	1.96744088574497	0.233062	0	GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005634,nucleus;GO:0031982,vesicle	GO:0004869,cysteine-type endopeptidase inhibitor activity;GO:0002020,protease binding;GO:0004867,serine-type endopeptidase inhibitor activity;GO:0001618,virus receptor activity	GO:0035425,autocrine signaling;GO:0043086,negative regulation of catalytic activity;GO:0010951,negative regulation of endopeptidase activity;GO:0043508,negative regulation of JUN kinase activity;GO:0010466,negative regulation of peptidase activity;GO:0045861,negative regulation of proteolysis;GO:0043312,neutrophil degranulation;GO:0038001,paracrine signaling;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0010950,positive regulation of endopeptidase activity;GO:0010718,positive regulation of epithelial to mesenchymal transition	hsa:6317,path:hsa05146,Amoebiasis
GALT2_HUMAN	Q10471	GALNT2	Polypeptide N-acetylgalactosaminyltransferase 2	0.518441168	0.796022577	0.676805692	0.355246804	0.6572318725	0.516026248	0.6572318725	0.516026248	1.27364039144768	0.355051	0	0.785150978812276	0.354695	0	GO:0005789,endoplasmic reticulum membrane;GO:0005576,extracellular region;GO:0005794,Golgi apparatus;GO:0032580,Golgi cisterna membrane;GO:0000139,Golgi membrane;GO:0005795,Golgi stack;GO:0030173,integral component of Golgi membrane;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm	GO:0030246,carbohydrate binding;GO:0030145,manganese ion binding;GO:0004653,polypeptide N-acetylgalactosaminyltransferase activity	GO:0016266,O-glycan processing;GO:0051604,protein maturation;GO:0006493,protein O-linked glycosylation;GO:0018242,protein O-linked glycosylation via serine;GO:0018243,protein O-linked glycosylation via threonine	hsa:2590,path:hsa00512,Mucin type O-glycan biosynthesis;hsa:2590,path:hsa00514,Other types of O-glycan biosynthesis
OLA1_HUMAN	Q9NTK5	OLA1	Obg-like ATPase 1	3.546733215	3.082992561	2.560922874	3.55376305	3.314862888	3.057342962	3.314862888	3.057342962	1.08422997655178	0.406712	0	0.922313551208336	0.406459	0	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0016020,membrane;GO:0005730,nucleolus;GO:0031093,platelet alpha granule lumen	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0045296,cadherin binding;GO:0005525,GTP binding;GO:0046872,metal ion binding;GO:0043023,ribosomal large subunit binding;GO:0043022,ribosome binding;GO:0016787,hydrolase activity	GO:0046034,ATP metabolic process;GO:0002576,platelet degranulation	
ADH7_HUMAN	P40394	ADH7	All-trans-retinol dehydrogenase [NAD(+)] ADH7	1.732080432	1.442155532	1.955098406	4.327883099	1.587117982	3.1414907525	1.587117982	3.1414907525	0.505211731321179	0.229923	0	1.97936813023898	0.230250	0	GO:0005829,cytosol;GO:0005886,plasma membrane	GO:0004022,alcohol dehydrogenase (NAD+) activity;GO:0004024,alcohol dehydrogenase activity, zinc-dependent;GO:0004031,aldehyde oxidase activity;GO:0035276,ethanol binding;GO:0050153,omega-hydroxydecanoate dehydrogenase activity;GO:0048019,receptor antagonist activity;GO:0019841,retinol binding;GO:0004745,retinol dehydrogenase activity;GO:0008270,zinc ion binding;GO:0016491,oxidoreductase activity	GO:0006068,ethanol catabolic process;GO:0006069,ethanol oxidation;GO:0010430,fatty acid omega-oxidation;GO:0009617,response to bacterium;GO:0045471,response to ethanol;GO:0042573,retinoic acid metabolic process;GO:0001523,retinoid metabolic process;GO:0042572,retinol metabolic process	hsa:131,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:131,path:hsa00071,Fatty acid degradation;hsa:131,path:hsa00350,Tyrosine metabolism;hsa:131,path:hsa00830,Retinol metabolism;hsa:131,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:131,path:hsa00982,Drug metabolism - cytochrome P450;hsa:131,path:hsa05204,Chemical carcinogenesis
RS19_HUMAN	P39019	RPS19	40S ribosomal protein S19	11.48249346	16.48516202	0.778678253	0.947339376	13.98382774	0.8630088145	13.98382774	0.8630088145	16.2035746391557	0.005945	1	0.0617147772802871	0.005848	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0014069,postsynaptic density;GO:0005840,ribosome	GO:0017134,fibroblast growth factor binding;GO:0042802,identical protein binding;GO:0019901,protein kinase binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0002181,cytoplasmic translation;GO:0050829,defense response to Gram-negative bacterium;GO:0030218,erythrocyte differentiation;GO:0031640,killing of cells of other organism;GO:0030490,maturation of SSU-rRNA;GO:0000462,maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0002548,monocyte chemotaxis;GO:0060266,negative regulation of respiratory burst involved in inflammatory response;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0007000,nucleolus organization;GO:0051272,positive regulation of cellular component movement;GO:0060265,positive regulation of respiratory burst involved in inflammatory response;GO:0009991,response to extracellular stimulus;GO:0000028,ribosomal small subunit assembly;GO:0042274,ribosomal small subunit biogenesis;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6223,path:hsa03010,Ribosome
SC23B_HUMAN	Q15437	SEC23B	Protein transport protein Sec23B	2.933876044	1.623036227	4.184664939	0.969742683	2.2784561355	2.577203811	2.2784561355	2.577203811	0.884080694656399	0.474484	0	1.13111846695018	0.474377	0	GO:0030127,COPII vesicle coat;GO:0005829,cytosol;GO:0012505,endomembrane system;GO:0005783,endoplasmic reticulum;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0048471,perinuclear region of cytoplasm;GO:0012507,ER to Golgi transport vesicle membrane	GO:0005096,GTPase activator activity;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0090110,COPII-coated vesicle cargo loading;GO:0006886,intracellular protein transport;GO:0015031,protein transport;GO:0016192,vesicle-mediated transport;GO:0090114,COPII-coated vesicle budding;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport	hsa:10483,path:hsa04141,Protein processing in endoplasmic reticulum
LV321_HUMAN	P80748	IGLV3-21	Immunoglobulin lambda variable 3-21	3.80018459	1.019950788	0.813901309	0.998409662	2.410067689	0.9061554855	2.410067689	0.9061554855	2.6596624172839	0.160517	0	0.375987566505233	0.159946	0	GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0070062,extracellular exosome;GO:0072562,blood microparticle	GO:0003823,antigen binding	GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
HSPB1_HUMAN	P04792	HSPB1	Heat shock protein beta-1	24.57306816	83.45979461	19.66883602	25.55248344	54.016431385	22.61065973	54.016431385	22.61065973	2.38898077411384	0.183563	0	0.41858855074752	0.182995	0	GO:1904115,axon cytoplasm;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0005634,nucleus;GO:0000502,proteasome complex;GO:0005819,spindle	GO:0042802,identical protein binding;GO:0044183,protein folding chaperone;GO:0042803,protein homodimerization activity;GO:0019901,protein kinase binding;GO:0005080,protein kinase C binding;GO:0008426,protein kinase C inhibitor activity;GO:0003723,RNA binding;GO:0061629,RNA polymerase II-specific DNA-binding transcription factor binding;GO:0043130,ubiquitin binding	GO:0099641,anterograde axonal protein transport;GO:0035924,cellular response to vascular endothelial growth factor stimulus;GO:0061077,chaperone-mediated protein folding;GO:0035556,intracellular signal transduction;GO:0043066,negative regulation of apoptotic process;GO:1902176,negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:0006469,negative regulation of protein kinase activity;GO:0070527,platelet aggregation;GO:0045766,positive regulation of angiogenesis;GO:0043536,positive regulation of blood vessel endothelial cell migration;GO:2001028,positive regulation of endothelial cell chemotaxis;GO:0038033,positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway;GO:0032731,positive regulation of interleukin-1 beta production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0010506,regulation of autophagy;GO:0043122,regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043488,regulation of mRNA stability;GO:0001932,regulation of protein phosphorylation;GO:0006446,regulation of translational initiation;GO:0006986,response to unfolded protein;GO:0009615,response to virus;GO:0001895,retina homeostasis;GO:0016032,viral process	hsa:3315,path:hsa04010,MAPK signaling pathway;hsa:3315,path:hsa04370,VEGF signaling pathway;hsa:3315,path:hsa05146,Amoebiasis
CD2B2_HUMAN	O95400	CD2BP2	CD2 antigen cytoplasmic tail-binding protein 2	0.144680548	0.043094455	0.062188531	2.55E-05	0.0938875015	0.0311070155	0.0938875015	0.0311070155	3.01820987937592	0.135899	0	0.331322220775041	0.135338	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0001650,fibrillar center;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005682,U5 snRNP	GO:0043021,ribonucleoprotein complex binding	GO:0000398,mRNA splicing, via spliceosome;GO:0010923,negative regulation of phosphatase activity;GO:0000244,spliceosomal tri-snRNP complex assembly	
DOC11_HUMAN	Q5JSL3	DOCK11	Dedicator of cytokinesis protein 11	0.048555429	0.05814371	0.197917433	0.072299476	0.0533495695	0.1351084545	0.0533495695	0.1351084545	0.394864775098142	0.132274	0	2.5325125538267	0.132597	0	GO:0005829,cytosol	GO:0005085,guanyl-nucleotide exchange factor activity	GO:0001782,B cell homeostasis;GO:0007596,blood coagulation;GO:0002315,marginal zone B cell differentiation;GO:0051491,positive regulation of filopodium assembly;GO:0043547,positive regulation of GTPase activity;GO:0007264,small GTPase mediated signal transduction	
ARL3_HUMAN	P36405	ARL3	ADP-ribosylation factor-like protein 3	0.759176338	3.903657006	0.139742654	0.032530768	2.331416672	0.086136711	2.331416672	0.086136711	27.0664696264059	0.001600	1	0.036946081768433	0.001566	-1	GO:0005813,centrosome;GO:0005929,cilium;GO:0005737,cytoplasm;GO:0005881,cytoplasmic microtubule;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0015630,microtubule cytoskeleton;GO:0030496,midbody;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032391,photoreceptor connecting cilium;GO:0005876,spindle microtubule	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0032794,GTPase activating protein binding;GO:0003924,GTPase activity;GO:0000287,magnesium ion binding;GO:0008017,microtubule binding	GO:0060271,cilium assembly;GO:0006893,Golgi to plasma membrane transport;GO:0042073,intraciliary transport;GO:0001822,kidney development;GO:0000281,mitotic cytokinesis;GO:0042461,photoreceptor cell development;GO:0031116,positive regulation of microtubule polymerization;GO:0006892,post-Golgi vesicle-mediated transport;GO:1903441,protein localization to ciliary membrane;GO:0061512,protein localization to cilium;GO:0007264,small GTPase mediated signal transduction;GO:0007224,smoothened signaling pathway	
BDH_HUMAN	Q02338	BDH1	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	0.09506991	0.070178316	0.460891938	0.199932907	0.082624113	0.3304124225	0.082624113	0.3304124225	0.250063579252986	0.034851	-1	3.99898299059501	0.035030	1	GO:0099617,matrix side of mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0003858,3-hydroxybutyrate dehydrogenase activity;GO:0016491,oxidoreductase activity	GO:0046951,ketone body biosynthetic process;GO:0046952,ketone body catabolic process	hsa:622,path:hsa00650,Butanoate metabolism;hsa:622,path:hsa00072,Synthesis and degradation of ketone bodies
IQGA2_HUMAN	Q13576	IQGAP2	Ras GTPase-activating-like protein IQGAP2	2.233335436	0.705049332	3.42984562	3.038195119	1.469192384	3.2340203695	1.469192384	3.2340203695	0.454292866506325	0.183674	0	2.20122320583715	0.184010	0	GO:0015629,actin cytoskeleton;GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0030175,filopodium;GO:0030027,lamellipodium;GO:0005874,microtubule;GO:0005902,microvillus;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0071933,Arp2/3 complex binding;GO:0005516,calmodulin binding;GO:0005096,GTPase activator activity;GO:0005095,GTPase inhibitor activity;GO:0005547,phosphatidylinositol-3,4,5-trisphosphate binding;GO:0031267,small GTPase binding	GO:0034314,Arp2/3 complex-mediated actin nucleation;GO:0043312,neutrophil degranulation;GO:0032956,regulation of actin cytoskeleton organization;GO:2000249,regulation of actin cytoskeleton reorganization;GO:0007165,signal transduction;GO:0070493,thrombin-activated receptor signaling pathway;GO:0043087,regulation of GTPase activity	hsa:10788,path:hsa04810,Regulation of actin cytoskeleton
CPSF7_HUMAN	Q8N684	CPSF7	Cleavage and polyadenylation specificity factor subunit 7	1.03187255	0.851337165	1.531936446	1.736904768	0.9416048575	1.634420607	0.9416048575	1.634420607	0.576109266774559	0.295145	0	1.73578183457916	0.295437	0	GO:0005737,cytoplasm;GO:0016020,membrane;GO:0005847,mRNA cleavage and polyadenylation specificity factor complex;GO:0005849,mRNA cleavage factor complex;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003723,RNA binding;GO:0003676,nucleic acid binding	GO:1990120,messenger ribonucleoprotein complex assembly;GO:0031124,mRNA 3'-end processing;GO:0110104,mRNA alternative polyadenylation;GO:0000398,mRNA splicing, via spliceosome;GO:0098789,pre-mRNA cleavage required for polyadenylation;GO:0051290,protein heterotetramerization;GO:0051262,protein tetramerization;GO:0006369,termination of RNA polymerase II transcription	hsa:79869,path:hsa03015,mRNA surveillance pathway
GNAI2_HUMAN	P04899	GNAI2	Guanine nucleotide-binding protein G(i) subunit alpha-2	12.4430029	21.98830093	18.57860919	32.49013713	17.215651915	25.53437316	17.215651915	25.53437316	0.674214785188798	0.382813	0	1.48320686814955	0.383030	0	GO:0044297,cell body;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:1903561,extracellular vesicle;GO:0005834,heterotrimeric G-protein complex;GO:0016020,membrane;GO:0045121,membrane raft;GO:0030496,midbody;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0045202,synapse	GO:0001664,G protein-coupled receptor binding;GO:0031683,G-protein beta/gamma-subunit complex binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0046872,metal ion binding;GO:0019001,guanyl nucleotide binding	GO:0007189,adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193,adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007188,adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007049,cell cycle;GO:0051301,cell division;GO:0008283,cell population proliferation;GO:0007213,G protein-coupled acetylcholine receptor signaling pathway;GO:0001973,G protein-coupled adenosine receptor signaling pathway;GO:0007186,G protein-coupled receptor signaling pathway;GO:0007214,gamma-aminobutyric acid signaling pathway;GO:0007194,negative regulation of adenylate cyclase activity;GO:0140199,negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process;GO:2001234,negative regulation of apoptotic signaling pathway;GO:0045955,negative regulation of calcium ion-dependent exocytosis;GO:1903614,negative regulation of protein tyrosine phosphatase activity;GO:0050805,negative regulation of synaptic transmission;GO:0030168,platelet activation;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0046628,positive regulation of insulin receptor signaling pathway;GO:0033864,positive regulation of NAD(P)H oxidase activity;GO:2000179,positive regulation of neural precursor cell proliferation;GO:0035815,positive regulation of renal sodium excretion;GO:0032930,positive regulation of superoxide anion generation;GO:0035810,positive regulation of urine volume;GO:1904707,positive regulation of vascular associated smooth muscle cell proliferation;GO:0006457,protein folding;GO:0051924,regulation of calcium ion transport;GO:0007584,response to nutrient;GO:0007165,signal transduction	hsa:2771,path:hsa04015,Rap1 signaling pathway;hsa:2771,path:hsa04371,Apelin signaling pathway;hsa:2771,path:hsa04071,Sphingolipid signaling pathway;hsa:2771,path:hsa04024,cAMP signaling pathway;hsa:2771,path:hsa04022,cGMP-PKG signaling pathway;hsa:2771,path:hsa04540,Gap junction;hsa:2771,path:hsa04611,Platelet activation;hsa:2771,path:hsa04670,Leukocyte transendothelial migration;hsa:2771,path:hsa04062,Chemokine signaling pathway;hsa:2771,path:hsa04923,Regulation of lipolysis in adipocytes;hsa:2771,path:hsa04915,Estrogen signaling pathway;hsa:2771,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:2771,path:hsa04921,Oxytocin signaling pathway;hsa:2771,path:hsa04926,Relaxin signaling pathway;hsa:2771,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:2771,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:2771,path:hsa04916,Melanogenesis;hsa:2771,path:hsa04924,Renin secretion;hsa:2771,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:2771,path:hsa04971,Gastric acid secretion;hsa:2771,path:hsa04724,Glutamatergic synapse;hsa:2771,path:hsa04727,GABAergic synapse;hsa:2771,path:hsa04725,Cholinergic synapse;hsa:2771,path:hsa04728,Dopaminergic synapse;hsa:2771,path:hsa04726,Serotonergic synapse;hsa:2771,path:hsa04730,Long-term depression;hsa:2771,path:hsa04723,Retrograde endocannabinoid signaling;hsa:2771,path:hsa04360,Axon guidance;hsa:2771,path:hsa04713,Circadian entrainment;hsa:2771,path:hsa05200,Pathways in cancer;hsa:2771,path:hsa05012,Parkinson disease;hsa:2771,path:hsa05030,Cocaine addiction;hsa:2771,path:hsa05032,Morphine addiction;hsa:2771,path:hsa05034,Alcoholism;hsa:2771,path:hsa04934,Cushing syndrome;hsa:2771,path:hsa05133,Pertussis;hsa:2771,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:2771,path:hsa05163,Human cytomegalovirus infection;hsa:2771,path:hsa05145,Toxoplasmosis;hsa:2771,path:hsa05142,Chagas disease (American trypanosomiasis)
MMSA_HUMAN	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	0.737152171	1.132670325	4.059868815	4.173395431	0.934911248	4.116632123	0.934911248	4.116632123	0.227105852567337	0.024939	-1	4.40323306817248	0.025084	1	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0000062,fatty-acyl-CoA binding;GO:0018478,malonate-semialdehyde dehydrogenase (acetylating) activity;GO:0102662,malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity;GO:0004491,methylmalonate-semialdehyde dehydrogenase (acylating) activity;GO:0003723,RNA binding	GO:0009083,branched-chain amino acid catabolic process;GO:0050873,brown fat cell differentiation;GO:0006210,thymine catabolic process;GO:0019859,thymine metabolic process;GO:0006574,valine catabolic process;GO:0006573,valine metabolic process	hsa:4329,path:hsa00640,Propanoate metabolism;hsa:4329,path:hsa00562,Inositol phosphate metabolism;hsa:4329,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:4329,path:hsa00410,beta-Alanine metabolism
ALDOC_HUMAN	P09972	ALDOC	Fructose-bisphosphate aldolase C	3.155238154	2.464062252	4.842951525	2.955738768	2.809650203	3.8993451465	2.809650203	3.8993451465	0.720544116368335	0.422094	0	1.38784007430408	0.422271	0	GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0034774,secretory granule lumen;GO:1904724,tertiary granule lumen	GO:0008092,cytoskeletal protein binding;GO:0004332,fructose-bisphosphate aldolase activity	GO:0061621,canonical glycolysis;GO:0030855,epithelial cell differentiation;GO:0030388,fructose 1,6-bisphosphate metabolic process;GO:0006000,fructose metabolic process;GO:0006094,gluconeogenesis;GO:0006096,glycolytic process;GO:0043312,neutrophil degranulation	hsa:230,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:230,path:hsa00030,Pentose phosphate pathway;hsa:230,path:hsa00051,Fructose and mannose metabolism;hsa:230,path:hsa04066,HIF-1 signaling pathway
BCAM_HUMAN	P50895	BCAM	Basal cell adhesion molecule	0.181580691	0.364230498	1.380462925	19.84266382	0.2729055945	10.6115633725	0.2729055945	10.6115633725	0.0257177557085734	0.000000	-1	38.8836417660907	0.000000	1	GO:0062023,collagen-containing extracellular matrix;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0043236,laminin binding;GO:0005055,laminin receptor activity;GO:0008022,protein C-terminus binding;GO:0004888,transmembrane signaling receptor activity	GO:0007155,cell adhesion;GO:0007160,cell-matrix adhesion;GO:0007165,signal transduction	
TBC15_HUMAN	Q8TC07	TBC1D15	TBC1 domain family member 15	0.326836966	0.391899164	0.759546667	2.227191666	0.359368065	1.4933691665	0.359368065	1.4933691665	0.24064248349405	0.030567	-1	4.15554221964603	0.030732	1	GO:0005737,cytoplasm;GO:0005576,extracellular region	GO:0005096,GTPase activator activity	GO:0090630,activation of GTPase activity;GO:0006886,intracellular protein transport;GO:0043087,regulation of GTPase activity	hsa:64786,path:hsa04137,Mitophagy - animal
AK1C2_HUMAN	P52895	AKR1C2	Aldo-keto reductase family 1 member C2	0.182525579	6.062270984	2.580565029	0.893753148	3.1223982815	1.7371590885	3.1223982815	1.7371590885	1.79741642672239	0.253966	0	0.556354100882181	0.253452	0	GO:0005829,cytosol	GO:0044594,17-beta-hydroxysteroid dehydrogenase (NAD+) activity;GO:0072582,17-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:0004032,alditol;GO:0047044,androstan-3-alpha,17-beta-diol dehydrogenase activity;GO:0047023,androsterone dehydrogenase activity;GO:0032052,bile acid binding;GO:0031406,carboxylic acid binding;GO:0047834,D-threo-aldose 1-dehydrogenase activity;GO:0047718,indanol dehydrogenase activity;GO:0047086,ketosteroid monooxygenase activity;GO:0016655,oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0018636,phenanthrene 9,10-monooxygenase activity;GO:0016229,steroid dehydrogenase activity;GO:0047115,trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity;GO:0004303,estradiol 17-beta-dehydrogenase activity	GO:0071395,cellular response to jasmonic acid stimulus;GO:0071799,cellular response to prostaglandin D stimulus;GO:0044597,daunorubicin metabolic process;GO:0007586,digestion;GO:0044598,doxorubicin metabolic process;GO:0030855,epithelial cell differentiation;GO:0007186,G protein-coupled receptor signaling pathway;GO:0008284,positive regulation of cell population proliferation;GO:0051897,positive regulation of protein kinase B signaling;GO:0042448,progesterone metabolic process;GO:0006693,prostaglandin metabolic process;GO:0008202,steroid metabolic process	hsa:1646,path:hsa00140,Steroid hormone biosynthesis;hsa:1646,path:hsa05204,Chemical carcinogenesis
VAPA_HUMAN	Q9P0L0	VAPA	Vesicle-associated membrane protein-associated protein A	1.859547341	1.775348576	1.273168431	0.402319182	1.8174479585	0.8377438065	1.8174479585	0.8377438065	2.16945555956193	0.205930	0	0.460945141555205	0.205372	0	GO:0035577,azurophil granule membrane;GO:0005923,bicellular tight junction;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0031965,nuclear membrane;GO:0005886,plasma membrane;GO:0031982,vesicle	GO:0045296,cadherin binding;GO:0033149,FFAT motif binding;GO:0008017,microtubule binding;GO:0019904,protein domain specific binding;GO:0046982,protein heterodimerization activity	GO:0008219,cell death;GO:0090114,COPII-coated vesicle budding;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0061025,membrane fusion;GO:0044828,negative regulation by host of viral genome replication;GO:0031175,neuron projection development;GO:0043312,neutrophil degranulation;GO:0044829,positive regulation by host of viral genome replication;GO:0044791,positive regulation by host of viral release from host cell;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045048,protein insertion into ER membrane;GO:0070972,protein localization to endoplasmic reticulum;GO:0030148,sphingolipid biosynthetic process;GO:0016032,viral process	hsa:9218,path:hsa04979,Cholesterol metabolism
DIAP1_HUMAN	O60610	DIAPH1	Protein diaphanous homolog 1	14.23251094	15.31097952	17.82661766	38.91343712	14.77174523	28.37002739	14.77174523	28.37002739	0.520681387681945	0.244152	0	1.92056029590757	0.244473	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0101003,ficolin-1-rich granule membrane;GO:0005815,microtubule organizing center;GO:0072686,mitotic spindle;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0032587,ruffle membrane;GO:0030667,secretory granule membrane	GO:0003779,actin binding;GO:0044325,ion channel binding;GO:0003723,RNA binding;GO:0005102,signaling receptor binding;GO:0031267,small GTPase binding	GO:0030036,actin cytoskeleton organization;GO:0030041,actin filament polymerization;GO:0071420,cellular response to histamine;GO:0007010,cytoskeleton organization;GO:0043312,neutrophil degranulation;GO:0035372,protein localization to microtubule;GO:2000145,regulation of cell motility;GO:0008360,regulation of cell shape;GO:0051493,regulation of cytoskeleton organization;GO:0032886,regulation of microtubule-based process;GO:0051279,regulation of release of sequestered calcium ion into cytosol;GO:0007605,sensory perception of sound;GO:0030335,positive regulation of cell migration	hsa:1729,path:hsa04510,Focal adhesion;hsa:1729,path:hsa04810,Regulation of actin cytoskeleton;hsa:1729,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:1729,path:hsa05131,Shigellosis
SNTB1_HUMAN	Q13884	SNTB1	Beta-1-syntrophin	0.148017811	0.188527531	0.462152356	0.942294307	0.168272671	0.7022233315	0.168272671	0.7022233315	0.239628425105952	0.030124	-1	4.17312762272609	0.030287	1	GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0016010,dystrophin-associated glycoprotein complex;GO:0005925,focal adhesion;GO:0032991,protein-containing complex;GO:0042383,sarcolemma;GO:0045202,synapse;GO:0030054,cell junction;GO:0016020,membrane	GO:0003779,actin binding;GO:0005516,calmodulin binding;GO:0030165,PDZ domain binding;GO:0005198,structural molecule activity	GO:0006936,muscle contraction	
GPC6_HUMAN	Q9Y625	GPC6	Glypican-6	0.097311182	0.044718454	0.156659103	0.144431167	0.071014818	0.150545135	0.071014818	0.150545135	0.471717787492767	0.199354	0	2.11991157958048	0.199688	0	GO:0046658,anchored component of plasma membrane;GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0005615,extracellular space;GO:0098978,glutamatergic synapse;GO:0005796,Golgi lumen;GO:0043202,lysosomal lumen;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0045202,synapse	GO:1904929,coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway	GO:0016477,cell migration;GO:0006024,glycosaminoglycan biosynthetic process;GO:0006027,glycosaminoglycan catabolic process;GO:0098696,regulation of neurotransmitter receptor localization to postsynaptic specialization membrane;GO:1905606,regulation of presynapse assembly;GO:1905475,regulation of protein localization to membrane;GO:0009966,regulation of signal transduction;GO:0001523,retinoid metabolic process;GO:0099560,synaptic membrane adhesion	
VPS11_HUMAN	Q9H270	VPS11	Vacuolar protein sorting-associated protein 11 homolog	0.046023247	0.298009958	0.496823057	0.156455228	0.1720166025	0.3266391425	0.1720166025	0.3266391425	0.526625808479154	0.249628	0	1.8988814902329	0.249947	0	GO:0005776,autophagosome;GO:0030136,clathrin-coated vesicle;GO:0005769,early endosome;GO:0030139,endocytic vesicle;GO:0005768,endosome;GO:0030897,HOPS complex;GO:0005770,late endosome;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0033263,CORVET complex;GO:0016020,membrane;GO:0005884,actin filament;GO:0030123,AP-3 adaptor complex;GO:0048786,presynaptic active zone	GO:0046872,metal ion binding;GO:0000166,nucleotide binding;GO:0019904,protein domain specific binding;GO:0030674,protein-macromolecule adaptor activity;GO:0019905,syntaxin binding;GO:0061630,ubiquitin protein ligase activity	GO:0006914,autophagy;GO:0034058,endosomal vesicle fusion;GO:0007032,endosome organization;GO:0008333,endosome to lysosome transport;GO:0006886,intracellular protein transport;GO:0033147,negative regulation of intracellular estrogen receptor signaling pathway;GO:1903364,positive regulation of cellular protein catabolic process;GO:2000643,positive regulation of early endosome to late endosome transport;GO:1903955,positive regulation of protein targeting to mitochondrion;GO:0016567,protein ubiquitination;GO:1902115,regulation of organelle assembly;GO:0031647,regulation of protein stability;GO:0035542,regulation of SNARE complex assembly;GO:0007033,vacuole organization;GO:0006904,vesicle docking involved in exocytosis;GO:0016192,vesicle-mediated transport;GO:1901998,toxin transport	hsa:55823,path:hsa05132,Salmonella infection
RAB18_HUMAN	Q9NP72	RAB18	Ras-related protein Rab-18	6.742660712	20.31604633	0.996891721	0.383227101	13.529353521	0.690059411	13.529353521	0.690059411	19.6060705865803	0.003725	1	0.0510046108211234	0.003657	-1	GO:0016324,apical plasma membrane;GO:0005829,cytosol;GO:0012505,endomembrane system;GO:0005789,endoplasmic reticulum membrane;GO:0071782,endoplasmic reticulum tubular network;GO:0005794,Golgi apparatus;GO:0005811,lipid droplet;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0007420,brain development;GO:0071786,endoplasmic reticulum tubular network organization;GO:0001654,eye development;GO:0006886,intracellular protein transport;GO:0034389,lipid droplet organization;GO:0043312,neutrophil degranulation;GO:0007264,small GTPase mediated signal transduction;GO:0016032,viral process	
HS12A_HUMAN	O43301	HSPA12A	Heat shock 70 kDa protein 12A	0.112098964	0.107103016	0.058975268	0.993612926	0.10960099	0.526294097	0.10960099	0.526294097	0.208250464188657	0.018154	-1	4.80191006486347	0.018272	1	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0005524,ATP binding		
CDK4_HUMAN	P11802	CDK4	Cyclin-dependent kinase 4	0.077546856	0.032030887	2.55E-05	0.485832359	0.0547888715	0.2429289295	0.0547888715	0.2429289295	0.225534569360542	0.024327	-1	4.43391007788872	0.024470	1	GO:0005923,bicellular tight junction;GO:0000785,chromatin;GO:0097129,cyclin D2-CDK4 complex;GO:0000307,cyclin-dependent protein kinase holoenzyme complex;GO:0005829,cytosol;GO:0016592,mediator complex;GO:0031965,nuclear membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005667,transcription regulator complex	GO:0005524,ATP binding;GO:0030332,cyclin binding;GO:0004693,cyclin-dependent protein serine/threonine kinase activity;GO:0106310,protein serine kinase activity;GO:0106311,protein threonine kinase activity;GO:0044877,protein-containing complex binding;GO:0008353,RNA polymerase II CTD heptapeptide repeat kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0004672,protein kinase activity	GO:0060612,adipose tissue development;GO:0031100,animal organ regeneration;GO:0051301,cell division;GO:0032869,cellular response to insulin stimulus;GO:0071353,cellular response to interleukin-4;GO:1904637,cellular response to ionomycin;GO:0071222,cellular response to lipopolysaccharide;GO:1904628,cellular response to phorbol 13-acetate 12-myristate;GO:0007623,circadian rhythm;GO:0000082,G1/S transition of mitotic cell cycle;GO:0030851,granulocyte differentiation;GO:0002088,lens development in camera-type eye;GO:0071157,negative regulation of cell cycle arrest;GO:2000134,negative regulation of G1/S transition of mitotic cell cycle;GO:0043065,positive regulation of apoptotic process;GO:0045787,positive regulation of cell cycle;GO:0008284,positive regulation of cell population proliferation;GO:0045793,positive regulation of cell size;GO:0048146,positive regulation of fibroblast proliferation;GO:0010971,positive regulation of G2/M transition of mitotic cell cycle;GO:0045727,positive regulation of translation;GO:0006468,protein phosphorylation;GO:0051726,regulation of cell cycle;GO:0010468,regulation of gene expression;GO:0046626,regulation of insulin receptor signaling pathway;GO:0046890,regulation of lipid biosynthetic process;GO:0050994,regulation of lipid catabolic process;GO:0040014,regulation of multicellular organism growth;GO:0060260,regulation of transcription initiation from RNA polymerase II promoter;GO:0042493,response to drug;GO:0055093,response to hyperoxia;GO:0010288,response to lead ion;GO:0033574,response to testosterone;GO:0009636,response to toxic substance;GO:0007165,signal transduction	hsa:1019,path:hsa04151,PI3K-Akt signaling pathway;hsa:1019,path:hsa04110,Cell cycle;hsa:1019,path:hsa04115,p53 signaling pathway;hsa:1019,path:hsa04218,Cellular senescence;hsa:1019,path:hsa04530,Tight junction;hsa:1019,path:hsa04660,T cell receptor signaling pathway;hsa:1019,path:hsa05200,Pathways in cancer;hsa:1019,path:hsa05203,Viral carcinogenesis;hsa:1019,path:hsa05212,Pancreatic cancer;hsa:1019,path:hsa05225,Hepatocellular carcinoma;hsa:1019,path:hsa05214,Glioma;hsa:1019,path:hsa05220,Chronic myeloid leukemia;hsa:1019,path:hsa05218,Melanoma;hsa:1019,path:hsa05219,Bladder cancer;hsa:1019,path:hsa05224,Breast cancer;hsa:1019,path:hsa05222,Small cell lung cancer;hsa:1019,path:hsa05223,Non-small cell lung cancer;hsa:1019,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:1019,path:hsa04934,Cushing syndrome;hsa:1019,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:1019,path:hsa05162,Measles;hsa:1019,path:hsa05164,Influenza A;hsa:1019,path:hsa05160,Hepatitis C;hsa:1019,path:hsa05163,Human cytomegalovirus infection;hsa:1019,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:1019,path:hsa05169,Epstein-Barr virus infection;hsa:1019,path:hsa05165,Human papillomavirus infection;hsa:1019,path:hsa01522,Endocrine resistance
ACS2L_HUMAN	Q9NUB1	ACSS1	Acetyl-coenzyme A synthetase 2-like, mitochondrial	0.14184966	0.106708417	0.47166472	0.319734823	0.1242790385	0.3956997715	0.1242790385	0.3956997715	0.314074071938149	0.071387	0	3.18396228580413	0.071648	0	GO:0005759,mitochondrial matrix	GO:0003987,acetate-CoA ligase activity;GO:0016208,AMP binding;GO:0005524,ATP binding;GO:0050218,propionate-CoA ligase activity	GO:0019413,acetate biosynthetic process;GO:0006085,acetyl-CoA biosynthetic process;GO:0019427,acetyl-CoA biosynthetic process from acetate;GO:0006069,ethanol oxidation;GO:0019542,propionate biosynthetic process	hsa:84532,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:84532,path:hsa00620,Pyruvate metabolism;hsa:84532,path:hsa00630,Glyoxylate and dicarboxylate metabolism;hsa:84532,path:hsa00640,Propanoate metabolism
KCAB2_HUMAN	Q13303	KCNAB2	Voltage-gated potassium channel subunit beta-2	0.159400815	0.101303636	0.491690939	0.096978224	0.1303522255	0.2943345815	0.1303522255	0.2943345815	0.442870915254652	0.173515	0	2.25799429484999	0.173850	0	GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0044224,juxtaparanode region of axon;GO:0016020,membrane;GO:1990031,pinceau fiber;GO:0005886,plasma membrane;GO:0035579,specific granule membrane;GO:0045202,synapse;GO:0070821,tertiary granule membrane;GO:0008076,voltage-gated potassium channel complex;GO:0016021,integral component of membrane;GO:0030424,axon;GO:0005737,cytoplasm	GO:0004033,aldo-keto reductase (NADP) activity;GO:0047834,D-threo-aldose 1-dehydrogenase activity;GO:0044325,ion channel binding;GO:0015459,potassium channel regulator activity;GO:0005249,voltage-gated potassium channel activity;GO:0005244,voltage-gated ion channel activity	GO:0070995,NADPH oxidation;GO:0043312,neutrophil degranulation;GO:0071805,potassium ion transmembrane transport;GO:0098900,regulation of action potential;GO:1901379,regulation of potassium ion transmembrane transport;GO:2000008,regulation of protein localization to cell surface;GO:0034765,regulation of ion transmembrane transport;GO:0006813,potassium ion transport	
H2AW_HUMAN	Q9P0M6	MACROH2A2	Core histone macro-H2A.2	0.158558585	0.219222994	0.165915818	0.126295687	0.1888907895	0.1461057525	0.1888907895	0.1461057525	1.29283608802467	0.350368	0	0.77349325971238	0.350003	0	GO:0001740,Barr body;GO:0000785,chromatin;GO:0000781,chromosome, telomeric region;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0000786,nucleosome	GO:0031490,chromatin DNA binding;GO:0003677,DNA binding;GO:0046982,protein heterodimerization activity;GO:0000977,RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976,transcription regulatory region sequence-specific DNA binding	GO:0007420,brain development;GO:0006342,chromatin silencing;GO:0007549,dosage compensation;GO:0071169,establishment of protein localization to chromatin;GO:0045814,negative regulation of gene expression, epigenetic;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:1901837,negative regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0006334,nucleosome assembly;GO:0045618,positive regulation of keratinocyte differentiation;GO:0006325,chromatin organization	hsa:55506,path:hsa04217,Necroptosis;hsa:55506,path:hsa05322,Systemic lupus erythematosus;hsa:55506,path:hsa05034,Alcoholism
RPRD2_HUMAN	Q5VT52	RPRD2	Regulation of nuclear pre-mRNA domain-containing protein 2	0.014604311	2.55E-05	0.032904826	2.55E-05	0.0073149055	0.016465163	0.0073149055	0.016465163	0.444265598828265	0.174750	0	2.25090577041631	0.175085	0	GO:0005654,nucleoplasm;GO:0016591,RNA polymerase II, holoenzyme	GO:0000993,RNA polymerase II complex binding	GO:0031124,mRNA 3'-end processing;GO:0042795,snRNA transcription by RNA polymerase II	
MAVS_HUMAN	Q7Z434	MAVS	Mitochondrial antiviral-signaling protein	0.105579245	0.203782748	0.228551651	0.167688161	0.1546809965	0.198119906	0.1546809965	0.198119906	0.780744346305111	0.470539	0	1.28082899957268	0.470663	0	GO:0016021,integral component of membrane;GO:0031966,mitochondrial membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0005778,peroxisomal membrane	GO:0050700,CARD domain binding;GO:0019901,protein kinase binding;GO:0035591,signaling adaptor activity	GO:0002218,activation of innate immune response;GO:0071360,cellular response to exogenous dsRNA;GO:0042742,defense response to bacterium;GO:0051607,defense response to virus;GO:0045087,innate immune response;GO:0032480,negative regulation of type I interferon production;GO:0045071,negative regulation of viral genome replication;GO:0071651,positive regulation of chemokine (C-C motif) ligand 5 production;GO:0002230,positive regulation of defense response to virus by host;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0032727,positive regulation of interferon-alpha production;GO:0032728,positive regulation of interferon-beta production;GO:0032755,positive regulation of interleukin-6 production;GO:0032757,positive regulation of interleukin-8 production;GO:0071660,positive regulation of IP-10 production;GO:0002735,positive regulation of myeloid dendritic cell cytokine production;GO:0042307,positive regulation of protein import into nucleus;GO:0001934,positive regulation of protein phosphorylation;GO:0060760,positive regulation of response to cytokine stimulus;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0032760,positive regulation of tumor necrosis factor production;GO:0060340,positive regulation of type I interferon-mediated signaling pathway;GO:1900063,regulation of peroxisome organization;GO:0007165,signal transduction;GO:0016032,viral process	hsa:57506,path:hsa04621,NOD-like receptor signaling pathway;hsa:57506,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:57506,path:hsa04623,Cytosolic DNA-sensing pathway;hsa:57506,path:hsa05162,Measles;hsa:57506,path:hsa05164,Influenza A;hsa:57506,path:hsa05161,Hepatitis B;hsa:57506,path:hsa05160,Hepatitis C;hsa:57506,path:hsa05168,Herpes simplex virus 1 infection;hsa:57506,path:hsa05169,Epstein-Barr virus infection
HSP7E_HUMAN	Q0VDF9	HSPA14	Heat shock 70 kDa protein 14	0.110858681	0.103537611	0.268840252	0.087595987	0.107198146	0.1782181195	0.107198146	0.1782181195	0.601499703289148	0.318283	0	1.66251121078157	0.318557	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0031072,heat shock protein binding;GO:0051787,misfolded protein binding;GO:0044183,protein folding chaperone;GO:0051082,unfolded protein binding	GO:0051083,'de novo' cotranslational protein folding;GO:0034620,cellular response to unfolded protein;GO:0051085,chaperone cofactor-dependent protein refolding;GO:0042026,protein refolding;GO:0016192,vesicle-mediated transport	
LAMB1_HUMAN	P07942	LAMB1	Laminin subunit beta-1	1.255452826	1.311796998	2.615716839	4.872926511	1.283624912	3.744321675	1.283624912	3.744321675	0.342819080040713	0.091479	0	2.91699050088239	0.091768	0	GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043256,laminin complex;GO:0005606,laminin-1 complex;GO:0043259,laminin-10 complex;GO:0005607,laminin-2 complex;GO:0043257,laminin-8 complex;GO:0048471,perinuclear region of cytoplasm;GO:0016020,membrane	GO:0005201,extracellular matrix structural constituent;GO:0005178,integrin binding;GO:0005198,structural molecule activity	GO:0009887,animal organ morphogenesis;GO:0070831,basement membrane assembly;GO:0007155,cell adhesion;GO:0016477,cell migration;GO:0044267,cellular protein metabolic process;GO:0035987,endodermal cell differentiation;GO:0030198,extracellular matrix organization;GO:0031175,neuron projection development;GO:0021812,neuronal-glial interaction involved in cerebral cortex radial glia guided migration;GO:0042476,odontogenesis;GO:0030335,positive regulation of cell migration;GO:0050679,positive regulation of epithelial cell proliferation;GO:0043687,post-translational protein modification;GO:0034446,substrate adhesion-dependent cell spreading;GO:0009888,tissue development	hsa:3912,path:hsa04151,PI3K-Akt signaling pathway;hsa:3912,path:hsa04512,ECM-receptor interaction;hsa:3912,path:hsa04510,Focal adhesion;hsa:3912,path:hsa05200,Pathways in cancer;hsa:3912,path:hsa05222,Small cell lung cancer;hsa:3912,path:hsa05165,Human papillomavirus infection;hsa:3912,path:hsa05146,Amoebiasis;hsa:3912,path:hsa05145,Toxoplasmosis
BZW2_HUMAN	Q9Y6E2	BZW2	Basic leucine zipper and W2 domain-containing protein 2	1.375645726	1.186393314	1.58601886	0.927691391	1.28101952	1.2568551255	1.28101952	1.2568551255	1.01922607785872	0.427046	0	0.981136591501744	0.426836	0	GO:0005737,cytoplasm;GO:0016020,membrane	GO:0045296,cadherin binding	GO:0030154,cell differentiation;GO:0007399,nervous system development	
PARVB_HUMAN	Q9HBI1	PARVB	Beta-parvin	0.037568291	0.033806546	0.046131591	0.07436733	0.0356874185	0.0602494605	0.0356874185	0.0602494605	0.592327602667911	0.309951	0	1.68825493780112	0.310232	0	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0005886,plasma membrane;GO:0030018,Z disc;GO:0005856,cytoskeleton	GO:0003779,actin binding	GO:0031532,actin cytoskeleton reorganization;GO:0030031,cell projection assembly;GO:0007163,establishment or maintenance of cell polarity;GO:0071963,establishment or maintenance of cell polarity regulating cell shape;GO:0030032,lamellipodium assembly;GO:0034446,substrate adhesion-dependent cell spreading;GO:0007155,cell adhesion	hsa:29780,path:hsa04510,Focal adhesion
RS20_HUMAN	P60866	RPS20	40S ribosomal protein S20	12.43291935	11.12448994	2.108472679	0.926560162	11.778704645	1.5175164205	11.778704645	1.5175164205	7.76183010996289	0.029042	1	0.128835594934811	0.028755	-1	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0015935,small ribosomal subunit;GO:0005840,ribosome	GO:0097371,MDM2/MDM4 family protein binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome;GO:1990948,ubiquitin ligase inhibitor activity	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:1901798,positive regulation of signal transduction by p53 class mediator;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6224,path:hsa03010,Ribosome
SIRBL_HUMAN	Q5TFQ8	SIRPB1	Signal-regulatory protein beta-1 isoform 3	0.118490515	0.318976539	0.126853768	0.302008748	0.218733527	0.214431258	0.218733527	0.214431258	1.02006362803692	0.426774	0	0.980331003394829	0.426564	0	GO:0009986,cell surface;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0016021,integral component of membrane		GO:0007166,cell surface receptor signaling pathway;GO:0045087,innate immune response;GO:0043312,neutrophil degranulation;GO:0050766,positive regulation of phagocytosis;GO:0050870,positive regulation of T cell activation;GO:0007165,signal transduction	hsa:10326,path:hsa04380,Osteoclast differentiation
IPYR_HUMAN	Q15181	PPA1	Inorganic pyrophosphatase	4.674250367	2.536142451	7.211891733	2.820939972	3.605196409	5.0164158525	3.605196409	5.0164158525	0.71867973369937	0.420545	0	1.39144037755531	0.420724	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0004427,inorganic diphosphatase activity;GO:0000287,magnesium ion binding	GO:0071344,diphosphate metabolic process;GO:0006796,phosphate-containing compound metabolic process;GO:0006418,tRNA aminoacylation for protein translation	hsa:5464,path:hsa00190,Oxidative phosphorylation
UBP47_HUMAN	Q96K76	USP47	Ubiquitin carboxyl-terminal hydrolase 47	0.142645296	0.064842669	0.165900422	0.072131074	0.1037439825	0.119015748	0.1037439825	0.119015748	0.871682817134418	0.479225	0	1.14720627772314	0.479129	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0019005,SCF ubiquitin ligase complex	GO:0004197,cysteine-type endopeptidase activity;GO:0101005,deubiquitinase activity;GO:0004843,thiol-dependent deubiquitinase;GO:0071987,WD40-repeat domain binding	GO:0006284,base-excision repair;GO:0006974,cellular response to DNA damage stimulus;GO:0034644,cellular response to UV;GO:0035520,monoubiquitinated protein deubiquitination;GO:0043066,negative regulation of apoptotic process;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:1902230,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0045892,negative regulation of transcription, DNA-templated;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0030307,positive regulation of cell growth;GO:0016579,protein deubiquitination;GO:0031647,regulation of protein stability;GO:0042493,response to drug;GO:0006511,ubiquitin-dependent protein catabolic process	
RS4Y1_HUMAN	P22090	RPS4Y1	40S ribosomal protein S4, Y isoform 1	0.018007453	2.55E-05	2.55E-05	2.55E-05	0.0090164765	2.55e-005	0.0090164765	2.55e-005	353.58731372549	0.000000	1	0.00282815576572511	0.000000	-1	GO:0005829,cytosol;GO:0022627,cytosolic small ribosomal subunit;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005844,polysome;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0019843,rRNA binding;GO:0003735,structural constituent of ribosome	GO:0007275,multicellular organism development;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6192,path:hsa03010,Ribosome
NOMO2_HUMAN	Q5JPE7	NOMO2	Nodal modulator 2	2.09423297	1.75541907	2.683866611	2.179580958	1.92482602	2.4317237845	1.92482602	2.4317237845	0.791547967852679	0.478901	0	1.26334731515111	0.479015	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0032991,protein-containing complex	GO:0030246,carbohydrate binding		
ASSY_HUMAN	P00966	ASS1	Argininosuccinate synthase	0.350631493	3.130812597	1.946015447	2.416457125	1.740722045	2.181236286	1.740722045	2.181236286	0.798043777362688	0.483878	0	1.25306409042461	0.483987	0	GO:0070852,cell body fiber;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005764,lysosome;GO:0005741,mitochondrial outer membrane;GO:0005634,nucleus;GO:0043204,perikaryon	GO:0016597,amino acid binding;GO:0004055,argininosuccinate synthase activity;GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0003723,RNA binding;GO:0015643,toxic substance binding	GO:0006953,acute-phase response;GO:0007568,aging;GO:0006526,arginine biosynthetic process;GO:0000053,argininosuccinate metabolic process;GO:0006531,aspartate metabolic process;GO:0071418,cellular response to amine stimulus;GO:0071230,cellular response to amino acid stimulus;GO:0071242,cellular response to ammonium ion;GO:0071320,cellular response to cAMP;GO:0071549,cellular response to dexamethasone stimulus;GO:0071377,cellular response to glucagon stimulus;GO:0071346,cellular response to interferon-gamma;GO:0071499,cellular response to laminar fluid shear stress;GO:0071222,cellular response to lipopolysaccharide;GO:0071400,cellular response to oleic acid;GO:0071356,cellular response to tumor necrosis factor;GO:0007623,circadian rhythm;GO:0000052,citrulline metabolic process;GO:0060539,diaphragm development;GO:0001822,kidney development;GO:0001889,liver development;GO:0007494,midgut development;GO:1903038,negative regulation of leukocyte cell-cell adhesion;GO:0045429,positive regulation of nitric oxide biosynthetic process;GO:0042493,response to drug;GO:0032355,response to estradiol;GO:0060416,response to growth hormone;GO:0010046,response to mycotoxin;GO:0007584,response to nutrient;GO:0010043,response to zinc ion;GO:0000050,urea cycle	hsa:445,path:hsa00250,Alanine, aspartate and glutamate metabolism;hsa:445,path:hsa00220,Arginine biosynthesis;hsa:445,path:hsa05418,Fluid shear stress and atherosclerosis
CPNE1_HUMAN	Q99829	CPNE1	Copine-1	3.849540721	2.551341434	3.898023694	5.340148691	3.2004410775	4.6190861925	3.2004410775	4.6190861925	0.692873210007761	0.398827	0	1.44326550017542	0.399028	0	GO:0035577,azurophil granule membrane;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0031965,nuclear membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0005509,calcium ion binding;GO:0005544,calcium-dependent phospholipid binding;GO:0004175,endopeptidase activity;GO:0042802,identical protein binding;GO:0051059,NF-kappaB binding;GO:0001786,phosphatidylserine binding;GO:0005215,transporter activity	GO:0071277,cellular response to calcium ion;GO:0046474,glycerophospholipid biosynthetic process;GO:0006629,lipid metabolic process;GO:0043392,negative regulation of DNA binding;GO:0010629,negative regulation of gene expression;GO:1901223,negative regulation of NIK/NF-kappaB signaling;GO:1990138,neuron projection extension;GO:0043312,neutrophil degranulation;GO:0045666,positive regulation of neuron differentiation;GO:0051897,positive regulation of protein kinase B signaling;GO:1903265,positive regulation of tumor necrosis factor-mediated signaling pathway;GO:0006508,proteolysis;GO:0043122,regulation of I-kappaB kinase/NF-kappaB signaling;GO:0016192,vesicle-mediated transport	
C1S_HUMAN	P09871	C1S	Complement C1s subcomponent	1.067671536	0.818454469	1.082765002	3.223934154	0.9430630025	2.153349578	0.9430630025	2.153349578	0.437951650830379	0.169174	0	2.28335707401479	0.169509	0	GO:0072562,blood microparticle;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0005509,calcium ion binding;GO:0042802,identical protein binding;GO:0004252,serine-type endopeptidase activity	GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0045087,innate immune response;GO:0030449,regulation of complement activation	hsa:716,path:hsa04610,Complement and coagulation cascades;hsa:716,path:hsa05322,Systemic lupus erythematosus;hsa:716,path:hsa05133,Pertussis;hsa:716,path:hsa05150,Staphylococcus aureus infection
RL34_HUMAN	P49207	RPL34	60S ribosomal protein L34	1.776552533	6.407401602	0.46966735	2.327257405	4.0919770675	1.3984623775	4.0919770675	1.3984623775	2.92605445333119	0.141682	0	0.341757139502835	0.141117	0	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome	GO:0045296,cadherin binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6164,path:hsa03010,Ribosome
SDF2L_HUMAN	Q9HCN8	SDF2L1	Stromal cell-derived factor 2-like protein 1	0.708300197	0.513434402	0.079541579	2.55E-05	0.6108672995	0.0397835395	0.6108672995	0.0397835395	15.3547750445885	0.006754	1	0.0651263204505515	0.006649	-1	GO:0101031,chaperone complex;GO:0005783,endoplasmic reticulum;GO:0034663,endoplasmic reticulum chaperone complex;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane	GO:0051117,ATPase binding;GO:0051087,chaperone binding;GO:0004169,dolichyl-phosphate-mannose-protein mannosyltransferase activity;GO:0051787,misfolded protein binding	GO:0051085,chaperone cofactor-dependent protein refolding;GO:0071712,ER-associated misfolded protein catabolic process;GO:0035269,protein O-linked mannosylation;GO:0042981,regulation of apoptotic process	
ERP29_HUMAN	P30040	ERP29	Endoplasmic reticulum resident protein 29	4.802527302	8.404071144	6.196259042	2.68591164	6.603299223	4.441085341	6.603299223	4.441085341	1.48686609600552	0.307768	0	0.672555519751585	0.307329	0	GO:0009986,cell surface;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0042470,melanosome;GO:0016020,membrane;GO:0005790,smooth endoplasmic reticulum;GO:0030133,transport vesicle	GO:0051087,chaperone binding;GO:0042803,protein homodimerization activity	GO:0000187,activation of MAPK activity;GO:0006886,intracellular protein transport;GO:0010629,negative regulation of gene expression;GO:0050709,negative regulation of protein secretion;GO:0010628,positive regulation of gene expression;GO:0001934,positive regulation of protein phosphorylation;GO:0006457,protein folding;GO:0018215,protein phosphopantetheinylation;GO:0009306,protein secretion;GO:0043335,protein unfolding;GO:1902235,regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	hsa:10961,path:hsa04141,Protein processing in endoplasmic reticulum
NEUA_HUMAN	Q8NFW8	CMAS	N-acylneuraminate cytidylyltransferase	0.483557489	0.405918861	0.629564015	0.157413428	0.444738175	0.3934887215	0.444738175	0.3934887215	1.13024376735535	0.393179	0	0.88476488779044	0.392898	0	GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0008781,N-acylneuraminate cytidylyltransferase activity	GO:0006054,N-acetylneuraminate metabolic process	hsa:55907,path:hsa00520,Amino sugar and nucleotide sugar metabolism
RBM14_HUMAN	Q96PK6	RBM14	RNA-binding protein 14	3.735817818	1.844180695	3.074943132	3.491136914	2.7899992565	3.283040023	2.7899992565	3.283040023	0.849821883666997	0.487758	0	1.17671716770223	0.487681	0	GO:0005737,cytoplasm;GO:0016607,nuclear speck;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0005667,transcription regulator complex	GO:0003729,mRNA binding;GO:0030374,nuclear receptor coactivator activity;GO:0003723,RNA binding	GO:0002218,activation of innate immune response;GO:0098534,centriole assembly;GO:0016575,histone deacetylation;GO:0045087,innate immune response;GO:0000398,mRNA splicing, via spliceosome;GO:0046600,negative regulation of centriole replication;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0009725,response to hormone;GO:0060395,SMAD protein signal transduction	
TIM44_HUMAN	O43615	TIMM44	Mitochondrial import inner membrane translocase subunit TIM44	0.706906624	0.550059282	0.735282957	0.704986785	0.628482953	0.720134871	0.628482953	0.720134871	0.872729509858717	0.478822	0	1.14583039613487	0.478725	0	GO:0001650,fibrillar center;GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0051087,chaperone binding	GO:0030150,protein import into mitochondrial matrix;GO:0006626,protein targeting to mitochondrion	
PLRKT_HUMAN	Q9HBL7	PLGRKT	Plasminogen receptor (KT)	2.0891825	1.641052069	0.275519346	0.081326394	1.8651172845	0.17842287	1.8651172845	0.17842287	10.4533532304463	0.015937	1	0.0956630832188291	0.015742	-1	GO:0005887,integral component of plasma membrane		GO:0006935,chemotaxis;GO:0006954,inflammatory response;GO:0010756,positive regulation of plasminogen activation	
DNPH1_HUMAN	O43598	DNPH1	2'-deoxynucleoside 5'-phosphate N-hydrolase 1	1.198781838	1.222587868	0.182191868	0.009888631	1.210684853	0.0960402495	1.210684853	0.0960402495	12.6060152832069	0.010617	1	0.0793272082838225	0.010470	-1	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0070694,deoxyribonucleoside 5'-monophosphate N-glycosidase activity;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity	GO:0009159,deoxyribonucleoside monophosphate catabolic process;GO:0030855,epithelial cell differentiation;GO:0009116,nucleoside metabolic process;GO:0030307,positive regulation of cell growth;GO:0006195,purine nucleotide catabolic process;GO:0009117,nucleotide metabolic process	
CAPR1_HUMAN	Q14444	CAPRIN1	Caprin-1	2.231136163	1.828761766	3.735828452	14.5584978	2.0299489645	9.147163126	2.0299489645	9.147163126	0.221921150474517	0.022951	-1	4.50610497404946	0.023088	1	GO:0031252,cell leading edge;GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0030425,dendrite;GO:0030027,lamellipodium;GO:0016020,membrane;GO:0000932,P-body;GO:0045202,synapse	GO:0003723,RNA binding	GO:0017148,negative regulation of translation;GO:0050775,positive regulation of dendrite morphogenesis;GO:0061003,positive regulation of dendritic spine morphogenesis;GO:0030154,cell differentiation	
EXOS9_HUMAN	Q06265	EXOSC9	Exosome complex component RRP45	0.191295805	0.062081047	0.186293355	0.176355294	0.126688426	0.1813243245	0.126688426	0.1813243245	0.698684119460211	0.403762	0	1.4312619567947	0.403958	0	GO:0005737,cytoplasm;GO:0000177,cytoplasmic exosome (RNase complex);GO:0005829,cytosol;GO:0000178,exosome (RNase complex);GO:0070062,extracellular exosome;GO:0000228,nuclear chromosome;GO:0000176,nuclear exosome (RNase complex);GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0000175,3'-5'-exoribonuclease activity;GO:0035925,mRNA 3'-UTR AU-rich region binding;GO:0003723,RNA binding;GO:0001102,RNA polymerase II activating transcription factor binding	GO:0043928,exonucleolytic catabolism of deadenylated mRNA;GO:0000467,exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006955,immune response;GO:0071028,nuclear mRNA surveillance;GO:0071042,nuclear polyadenylation-dependent mRNA catabolic process;GO:0071035,nuclear polyadenylation-dependent rRNA catabolic process;GO:0071038,nuclear polyadenylation-dependent tRNA catabolic process;GO:0000956,nuclear-transcribed mRNA catabolic process;GO:0034427,nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';GO:0030307,positive regulation of cell growth;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0043488,regulation of mRNA stability;GO:0016075,rRNA catabolic process;GO:0006364,rRNA processing;GO:0034473,U1 snRNA 3'-end processing;GO:0034475,U4 snRNA 3'-end processing;GO:0034476,U5 snRNA 3'-end processing;GO:0006396,RNA processing	hsa:5393,path:hsa03018,RNA degradation
GSH0_HUMAN	P48507	GCLM	Glutamate--cysteine ligase regulatory subunit	0.182670526	0.31182605	0.409915969	0.217102443	0.247248288	0.313509206	0.247248288	0.313509206	0.788647616299982	0.476666	0	1.26799343500409	0.476783	0	GO:0005829,cytosol;GO:0017109,glutamate-cysteine ligase complex	GO:0047834,D-threo-aldose 1-dehydrogenase activity;GO:0030234,enzyme regulator activity;GO:0004357,glutamate-cysteine ligase activity;GO:0035226,glutamate-cysteine ligase catalytic subunit binding;GO:0044877,protein-containing complex binding	GO:0007568,aging;GO:0008637,apoptotic mitochondrial changes;GO:0097746,blood vessel diameter maintenance;GO:0044344,cellular response to fibroblast growth factor stimulus;GO:0071372,cellular response to follicle-stimulating hormone stimulus;GO:0071333,cellular response to glucose stimulus;GO:0035729,cellular response to hepatocyte growth factor stimulus;GO:1990830,cellular response to leukemia inhibitory factor;GO:0097069,cellular response to thyroxine stimulus;GO:0006534,cysteine metabolic process;GO:0006536,glutamate metabolic process;GO:0006750,glutathione biosynthetic process;GO:0035733,hepatic stellate cell activation;GO:2001237,negative regulation of extrinsic apoptotic signaling pathway;GO:0043524,negative regulation of neuron apoptotic process;GO:0035229,positive regulation of glutamate-cysteine ligase activity;GO:0051900,regulation of mitochondrial depolarization;GO:0014823,response to activity;GO:0042493,response to drug;GO:0044752,response to human chorionic gonadotropin;GO:0051409,response to nitrosative stress;GO:0007584,response to nutrient;GO:0006979,response to oxidative stress	hsa:2730,path:hsa00270,Cysteine and methionine metabolism;hsa:2730,path:hsa00480,Glutathione metabolism;hsa:2730,path:hsa04216,Ferroptosis
K1C19_HUMAN	P08727	KRT19	Keratin, type I cytoskeletal 19	246.85042	463.1281748	193.5167165	215.2969805	354.9892974	204.4068485	354.9892974	204.4068485	1.73668005746882	0.263338	0	0.575811299092985	0.262836	0	GO:0016327,apicolateral plasma membrane;GO:0071944,cell periphery;GO:0043034,costamere;GO:0005829,cytosol;GO:0016010,dystrophin-associated glycoprotein complex;GO:0070062,extracellular exosome;GO:0005882,intermediate filament;GO:0005886,plasma membrane;GO:0042383,sarcolemma;GO:1990357,terminal web;GO:0030018,Z disc	GO:0044877,protein-containing complex binding;GO:0005200,structural constituent of cytoskeleton;GO:0008307,structural constituent of muscle;GO:0005198,structural molecule activity	GO:0060706,cell differentiation involved in embryonic placenta development;GO:0070268,cornification;GO:0031424,keratinization;GO:0007219,Notch signaling pathway;GO:0043627,response to estrogen;GO:0045214,sarcomere organization;GO:0016032,viral process	hsa:3880,path:hsa04915,Estrogen signaling pathway;hsa:3880,path:hsa05150,Staphylococcus aureus infection
H3PS2_HUMAN	Q5TEC6	H3-2	Histone HIST2H3PS2	1.241341678	3.913717503	2.766644332	12.44264829	2.5775295905	7.604646311	2.5775295905	7.604646311	0.338941416219666	0.088654	0	2.9503623698554	0.088940	0	GO:0000786,nucleosome;GO:0005634,nucleus;GO:0000781,chromosome, telomeric region;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0001740,Barr body;GO:0005576,extracellular region;GO:0000228,nuclear chromosome;GO:0032991,protein-containing complex;GO:0000791,euchromatin	GO:0003677,DNA binding;GO:0046982,protein heterodimerization activity;GO:0031492,nucleosomal DNA binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000979,RNA polymerase II core promoter sequence-specific DNA binding	GO:0045007,depurination;GO:0006302,double-strand break repair;GO:0006303,double-strand break repair via nonhomologous end joining;GO:0048239,negative regulation of DNA recombination at telomere;GO:0006334,nucleosome assembly;GO:1900051,positive regulation of histone exchange;GO:0016233,telomere capping;GO:1990000,amyloid fibril formation;GO:0007596,blood coagulation;GO:0008283,cell population proliferation;GO:0006336,DNA replication-independent nucleosome assembly;GO:0007566,embryo implantation;GO:0008584,male gonad development;GO:0035264,multicellular organism growth;GO:0042692,muscle cell differentiation;GO:1902340,negative regulation of chromosome condensation;GO:0045814,negative regulation of gene expression, epigenetic;GO:0006997,nucleus organization;GO:0048477,oogenesis;GO:0001649,osteoblast differentiation;GO:0031508,pericentric heterochromatin assembly;GO:0030307,positive regulation of cell growth;GO:0000183,rDNA heterochromatin assembly;GO:0060765,regulation of androgen receptor signaling pathway;GO:0090230,regulation of centromere complex assembly;GO:0060964,regulation of gene silencing by miRNA;GO:0045652,regulation of megakaryocyte differentiation;GO:0007338,single fertilization;GO:0007286,spermatid development;GO:0031509,subtelomeric heterochromatin assembly;GO:0032200,telomere organization	hsa:8290,path:hsa05202,Transcriptional misregulation in cancer;hsa:8290,path:hsa05322,Systemic lupus erythematosus;hsa:8290,path:hsa05034,Alcoholism;hsa:8290,path:hsa05131,Shigellosis;hsa:3020,path:hsa05202,Transcriptional misregulation in cancer;hsa:3020,path:hsa05322,Systemic lupus erythematosus;hsa:3020,path:hsa05034,Alcoholism;hsa:3020,path:hsa05131,Shigellosis;hsa:3021,path:hsa05202,Transcriptional misregulation in cancer;hsa:3021,path:hsa05322,Systemic lupus erythematosus;hsa:3021,path:hsa05034,Alcoholism;hsa:3021,path:hsa05131,Shigellosis;hsa:440093,path:hsa05202,Transcriptional misregulation in cancer;hsa:440093,path:hsa05322,Systemic lupus erythematosus;hsa:440093,path:hsa05034,Alcoholism;hsa:440093,path:hsa05131,Shigellosis
NSUN2_HUMAN	Q08J23	NSUN2	RNA cytosine C(5)-methyltransferase NSUN2	0.63356828	0.449593939	0.773547517	0.502022042	0.5415811095	0.6377847795	0.5415811095	0.6377847795	0.849159664682779	0.488020	0	1.17763483310712	0.487943	0	GO:0033391,chromatoid body;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005819,spindle	GO:0008168,methyltransferase activity;GO:0062152,mRNA (cytidine-5-)-methyltransferase activity;GO:0003723,RNA binding;GO:0016428,tRNA (cytosine-5-)-methyltransferase activity;GO:0000049,tRNA binding	GO:0051301,cell division;GO:0048820,hair follicle maturation;GO:0001701,in utero embryonic development;GO:0033313,meiotic cell cycle checkpoint;GO:0080009,mRNA methylation;GO:0010793,regulation of mRNA export from nucleus;GO:2000736,regulation of stem cell differentiation;GO:0001510,RNA methylation;GO:0007286,spermatid development;GO:0030488,tRNA methylation;GO:0006400,tRNA modification;GO:0036416,tRNA stabilization	
PLSL_HUMAN	P13796	LCP1	Plastin-2	50.56157092	75.93177296	95.79095957	68.33924403	63.24667194	82.0651018	63.24667194	82.0651018	0.770689008515919	0.462664	0	1.297540238605	0.462797	0	GO:0015629,actin cytoskeleton;GO:0005884,actin filament;GO:0032432,actin filament bundle;GO:0030054,cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0030175,filopodium;GO:0005925,focal adhesion;GO:0001891,phagocytic cup;GO:0005886,plasma membrane;GO:0002102,podosome;GO:0001726,ruffle;GO:0032587,ruffle membrane	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0005509,calcium ion binding;GO:0051020,GTPase binding;GO:0042802,identical protein binding;GO:0005178,integrin binding	GO:0051764,actin crosslink formation;GO:0051017,actin filament bundle assembly;GO:0051639,actin filament network formation;GO:0031100,animal organ regeneration;GO:0016477,cell migration;GO:0030866,cortical actin cytoskeleton organization;GO:0022617,extracellular matrix disassembly;GO:0035722,interleukin-12-mediated signaling pathway;GO:0071803,positive regulation of podosome assembly;GO:0010737,protein kinase A signaling;GO:0033157,regulation of intracellular protein transport;GO:0002286,T cell activation involved in immune response	
SERA_HUMAN	O43175	PHGDH	D-3-phosphoglycerate dehydrogenase	1.139265004	0.751407838	1.82238082	1.436896541	0.945336421	1.6296386805	0.945336421	1.6296386805	0.580089582010876	0.298786	0	1.7238716760496	0.299076	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0009055,electron transfer activity;GO:0030060,L-malate dehydrogenase activity;GO:0051287,NAD binding;GO:0004617,phosphoglycerate dehydrogenase activity;GO:0016616,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO:0007420,brain development;GO:0070314,G1 to G0 transition;GO:0009448,gamma-aminobutyric acid metabolic process;GO:0021782,glial cell development;GO:0006541,glutamine metabolic process;GO:0006544,glycine metabolic process;GO:0006564,L-serine biosynthetic process;GO:0021915,neural tube development;GO:0031175,neuron projection development;GO:0010468,regulation of gene expression;GO:0021510,spinal cord development;GO:0019530,taurine metabolic process;GO:0006566,threonine metabolic process	hsa:26227,path:hsa00260,Glycine, serine and threonine metabolism;hsa:26227,path:hsa00270,Cysteine and methionine metabolism
CCS_HUMAN	O14618	CCS	Copper chaperone for superoxide dismutase	1.481365182	0.807532072	0.827329263	1.629620088	1.144448627	1.2284746755	1.144448627	1.2284746755	0.931601318142109	0.456946	0	1.07342055075051	0.456800	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus	GO:0045296,cadherin binding;GO:0005507,copper ion binding;GO:0046872,metal ion binding;GO:0004784,superoxide dismutase activity	GO:0034599,cellular response to oxidative stress;GO:0051353,positive regulation of oxidoreductase activity;GO:0015680,protein maturation by copper ion transfer;GO:0019430,removal of superoxide radicals;GO:0006801,superoxide metabolic process	hsa:9973,path:hsa05014,Amyotrophic lateral sclerosis (ALS)
SMD1_HUMAN	P62314	SNRPD1	Small nuclear ribonucleoprotein Sm D1	2.120867726	1.022758226	0.570632482	0.297693512	1.571812976	0.434162997	1.571812976	0.434162997	3.62032920092451	0.105240	0	0.27621797480313	0.104709	0	GO:0071013,catalytic step 2 spliceosome;GO:0000243,commitment complex;GO:0005829,cytosol;GO:0034709,methylosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0034715,pICln-Sm protein complex;GO:0071011,precatalytic spliceosome;GO:0030532,small nuclear ribonucleoprotein complex;GO:0034719,SMN-Sm protein complex;GO:0097526,spliceosomal tri-snRNP complex;GO:0005685,U1 snRNP;GO:0005689,U12-type spliceosomal complex;GO:0005686,U2 snRNP;GO:0071007,U2-type catalytic step 2 spliceosome;GO:0071005,U2-type precatalytic spliceosome;GO:0005687,U4 snRNP;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005682,U5 snRNP	GO:0003723,RNA binding;GO:1990446,U1 snRNP binding	GO:0051170,import into nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0008380,RNA splicing;GO:0000245,spliceosomal complex assembly;GO:0000387,spliceosomal snRNP assembly;GO:0006396,RNA processing	hsa:6632,path:hsa03040,Spliceosome;hsa:6632,path:hsa05322,Systemic lupus erythematosus
ECHD1_HUMAN	Q9NTX5	ECHDC1	Ethylmalonyl-CoA decarboxylase	2.463324293	1.390730749	2.370351466	4.987537706	1.927027521	3.678944586	1.927027521	3.678944586	0.523799007012279	0.247024	0	1.90912923967524	0.247343	0	GO:0005829,cytosol;GO:0016021,integral component of membrane	GO:0016831,carboxy-lyase activity;GO:0004300,enoyl-CoA hydratase activity;GO:0003824,catalytic activity	GO:0006635,fatty acid beta-oxidation	hsa:55862,path:hsa00640,Propanoate metabolism
UBA3_HUMAN	Q8TBC4	UBA3	NEDD8-activating enzyme E1 catalytic subunit	0.563828136	0.700173837	1.010432939	0.746187706	0.6320009865	0.8783103225	0.6320009865	0.8783103225	0.719564566543051	0.421280	0	1.38972935368986	0.421458	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0019781,NEDD8 activating enzyme activity;GO:0016922,nuclear receptor binding;GO:0046982,protein heterodimerization activity;GO:0044877,protein-containing complex binding	GO:0006464,cellular protein modification process;GO:0007113,endomitotic cell cycle;GO:0045892,negative regulation of transcription, DNA-templated;GO:0043687,post-translational protein modification;GO:0032446,protein modification by small protein conjugation;GO:0045116,protein neddylation;GO:0006508,proteolysis;GO:0051726,regulation of cell cycle	hsa:9039,path:hsa04120,Ubiquitin mediated proteolysis
PEBB_HUMAN	Q13951	CBFB	Core-binding factor subunit beta	0.457484186	0.995103564	0.035048639	0.00579122	0.726293875	0.0204199295	0.726293875	0.0204199295	35.5678933661353	0.000741	1	0.0281152439843996	0.000723	-1	GO:0016513,core-binding factor complex;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0043565,sequence-specific DNA binding;GO:0003713,transcription coactivator activity	GO:0048469,cell maturation;GO:0060216,definitive hemopoiesis;GO:0030098,lymphocyte differentiation;GO:0030099,myeloid cell differentiation;GO:0043371,negative regulation of CD4-positive, alpha-beta T cell differentiation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0001649,osteoblast differentiation;GO:0043378,positive regulation of CD8-positive, alpha-beta T cell differentiation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0000209,protein polyubiquitination;GO:0050855,regulation of B cell receptor signaling pathway;GO:2000810,regulation of bicellular tight junction assembly;GO:0001959,regulation of cytokine-mediated signaling pathway;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:0033146,regulation of intracellular estrogen receptor signaling pathway;GO:0045616,regulation of keratinocyte differentiation;GO:0045652,regulation of megakaryocyte differentiation;GO:0045637,regulation of myeloid cell differentiation;GO:0045589,regulation of regulatory T cell differentiation;GO:0006357,regulation of transcription by RNA polymerase II;GO:0060260,regulation of transcription initiation from RNA polymerase II promoter;GO:0030111,regulation of Wnt signaling pathway;GO:0006366,transcription by RNA polymerase II	
NEP1_HUMAN	Q92979	EMG1	Ribosomal RNA small subunit methyltransferase NEP1	0.100138695	0.032080008	0.106657138	2.55E-05	0.0661093515	0.053341319	0.0661093515	0.053341319	1.23936476898893	0.363647	0	0.806864956162821	0.363308	0	GO:0005694,chromosome;GO:0005737,cytoplasm;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032040,small-subunit processome	GO:0042802,identical protein binding;GO:0003723,RNA binding;GO:0070037,rRNA (pseudouridine) methyltransferase activity;GO:0019843,rRNA binding	GO:0001824,blastocyst development;GO:0017126,nucleologenesis;GO:0042274,ribosomal small subunit biogenesis;GO:0070475,rRNA base methylation;GO:0006364,rRNA processing	hsa:10436,path:hsa03008,Ribosome biogenesis in eukaryotes
PPCE_HUMAN	P48147	PREP	Prolyl endopeptidase	1.222783145	1.377106281	2.193054922	1.255319909	1.299944713	1.7241874155	1.299944713	1.7241874155	0.75394629453494	0.449355	0	1.326354419736	0.449503	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005634,nucleus	GO:0004175,endopeptidase activity;GO:0070012,oligopeptidase activity;GO:0004252,serine-type endopeptidase activity;GO:0008236,serine-type peptidase activity	GO:0006508,proteolysis	hsa:5550,path:hsa04614,Renin-angiotensin system
CRK_HUMAN	P46108	CRK	Adapter molecule crk	0.606351459	1.334252974	0.907786008	0.670751547	0.9703022165	0.7892687775	0.9703022165	0.7892687775	1.22936855499773	0.366213	0	0.813425718377713	0.365878	0	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0045121,membrane raft;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0032991,protein-containing complex	GO:0008092,cytoskeletal protein binding;GO:0046875,ephrin receptor binding;GO:0005159,insulin-like growth factor receptor binding;GO:0019900,kinase binding;GO:0001784,phosphotyrosine residue binding;GO:0045309,protein phosphorylated amino acid binding;GO:0043621,protein self-association;GO:1990782,protein tyrosine kinase binding;GO:0097110,scaffold protein binding;GO:0042169,SH2 domain binding;GO:0017124,SH3 domain binding;GO:0035591,signaling adaptor activity;GO:0030159,signaling receptor complex adaptor activity;GO:0031625,ubiquitin protein ligase binding	GO:0030036,actin cytoskeleton organization;GO:0090630,activation of GTPase activity;GO:0000186,activation of MAPKK activity;GO:0060326,cell chemotaxis;GO:1990859,cellular response to endothelin;GO:1990314,cellular response to insulin-like growth factor stimulus;GO:1990090,cellular response to nerve growth factor stimulus;GO:0071732,cellular response to nitric oxide;GO:0071560,cellular response to transforming growth factor beta stimulus;GO:0098749,cerebellar neuron development;GO:0021987,cerebral cortex development;GO:0019221,cytokine-mediated signaling pathway;GO:0016358,dendrite development;GO:0048013,ephrin receptor signaling pathway;GO:0030010,establishment of cell polarity;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0035685,helper T cell diapedesis;GO:0021766,hippocampus development;GO:0006629,lipid metabolic process;GO:2000146,negative regulation of cell motility;GO:0045953,negative regulation of natural killer cell mediated cytotoxicity;GO:0061045,negative regulation of wound healing;GO:0001764,neuron migration;GO:0030307,positive regulation of cell growth;GO:0014911,positive regulation of smooth muscle cell migration;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0038026,reelin-mediated signaling pathway;GO:0032956,regulation of actin cytoskeleton organization;GO:0033628,regulation of cell adhesion mediated by integrin;GO:0008360,regulation of cell shape;GO:0050773,regulation of dendrite development;GO:0043087,regulation of GTPase activity;GO:1902531,regulation of intracellular signal transduction;GO:0043393,regulation of protein binding;GO:0035020,regulation of Rac protein signal transduction;GO:0009966,regulation of signal transduction;GO:2000404,regulation of T cell migration;GO:0006357,regulation of transcription by RNA polymerase II;GO:0061847,response to cholecystokinin;GO:0035728,response to hepatocyte growth factor;GO:0042542,response to hydrogen peroxide;GO:0001878,response to yeast;GO:0048010,vascular endothelial growth factor receptor signaling pathway	hsa:1398,path:hsa04015,Rap1 signaling pathway;hsa:1398,path:hsa04010,MAPK signaling pathway;hsa:1398,path:hsa04012,ErbB signaling pathway;hsa:1398,path:hsa04510,Focal adhesion;hsa:1398,path:hsa04810,Regulation of actin cytoskeleton;hsa:1398,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:1398,path:hsa04062,Chemokine signaling pathway;hsa:1398,path:hsa04910,Insulin signaling pathway;hsa:1398,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:1398,path:hsa04722,Neurotrophin signaling pathway;hsa:1398,path:hsa05200,Pathways in cancer;hsa:1398,path:hsa05206,MicroRNAs in cancer;hsa:1398,path:hsa05220,Chronic myeloid leukemia;hsa:1398,path:hsa05211,Renal cell carcinoma;hsa:1398,path:hsa05131,Shigellosis;hsa:1398,path:hsa05135,Yersinia infection;hsa:1398,path:hsa05100,Bacterial invasion of epithelial cells;hsa:1398,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:1398,path:hsa05163,Human cytomegalovirus infection
TRYB1_HUMAN	Q15661	TPSAB1	Tryptase alpha/beta-1	4.366426461	8.935626965	7.024112602	96.75394655	6.651026713	51.889029576	6.651026713	51.889029576	0.128177897473655	0.002290	-1	7.80165706966391	0.002315	1	GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0042802,identical protein binding;GO:0004252,serine-type endopeptidase activity;GO:0008236,serine-type peptidase activity	GO:0006952,defense response;GO:0022617,extracellular matrix disassembly;GO:0006508,proteolysis	hsa:7177,path:hsa05164,Influenza A
S10A7_HUMAN	P31151	S100A7	Protein S100-A7	0.161035815	1.560288662	0.158176011	0.464256584	0.8606622385	0.3112162975	0.8606622385	0.3112162975	2.76547933194276	0.152629	0	0.361600966765315	0.152061	0	GO:0035578,azurophil granule lumen;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0005634,nucleus	GO:0005509,calcium ion binding;GO:0048306,calcium-dependent protein binding;GO:0050786,RAGE receptor binding;GO:0008270,zinc ion binding	GO:0001525,angiogenesis;GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0019730,antimicrobial humoral response;GO:0050829,defense response to Gram-negative bacterium;GO:0008544,epidermis development;GO:0045087,innate immune response;GO:0030216,keratinocyte differentiation;GO:0043312,neutrophil degranulation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0071624,positive regulation of granulocyte chemotaxis;GO:0090026,positive regulation of monocyte chemotaxis;GO:0010820,positive regulation of T cell chemotaxis;GO:0032496,response to lipopolysaccharide;GO:0000302,response to reactive oxygen species;GO:0051238,sequestering of metal ion	hsa:6278,path:hsa04657,IL-17 signaling pathway
PPOX_HUMAN	P50336	PPOX	Protoporphyrinogen oxidase	0.355686242	0.509734284	0.525863808	0.365904207	0.432710263	0.4458840075	0.432710263	0.4458840075	0.970454772365883	0.443315	0	1.03044472393298	0.443139	0	GO:0031305,integral component of mitochondrial inner membrane;GO:0031304,intrinsic component of mitochondrial inner membrane;GO:0005758,mitochondrial intermembrane space;GO:0031966,mitochondrial membrane;GO:0005743,mitochondrial inner membrane	GO:0050660,flavin adenine dinucleotide binding;GO:0016491,oxidoreductase activity;GO:0004729,oxygen-dependent protoporphyrinogen oxidase activity	GO:0006783,heme biosynthetic process;GO:0006779,porphyrin-containing compound biosynthetic process;GO:0006782,protoporphyrinogen IX biosynthetic process;GO:0042493,response to drug	hsa:5498,path:hsa00860,Porphyrin and chlorophyll metabolism
CTNA1_HUMAN	P35221	CTNNA1	Catenin alpha-1	5.952232011	4.313996373	6.72955607	9.384625691	5.133114192	8.0570908805	5.133114192	8.0570908805	0.637092750737528	0.350248	0	1.56963016584689	0.350496	0	GO:0001669,acrosomal vesicle;GO:0015629,actin cytoskeleton;GO:0005912,adherens junction;GO:0016342,catenin complex;GO:0030054,cell junction;GO:0005911,cell-cell junction;GO:0005829,cytosol;GO:0016600,flotillin complex;GO:0005925,focal adhesion;GO:0014704,intercalated disc;GO:0043231,intracellular membrane-bounded organelle;GO:0030027,lamellipodium;GO:0005886,plasma membrane;GO:0005915,zonula adherens;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0016020,membrane	GO:0051015,actin filament binding;GO:0008013,beta-catenin binding;GO:0045296,cadherin binding;GO:0045295,gamma-catenin binding;GO:0042802,identical protein binding;GO:0003723,RNA binding;GO:0005198,structural molecule activity;GO:0017166,vinculin binding	GO:0007015,actin filament organization;GO:0034332,adherens junction organization;GO:0007568,aging;GO:0043297,apical junction assembly;GO:0031103,axon regeneration;GO:0007155,cell adhesion;GO:0016477,cell migration;GO:0098609,cell-cell adhesion;GO:0034613,cellular protein localization;GO:0071681,cellular response to indole-3-methanol;GO:0090136,epithelial cell-cell adhesion;GO:0007163,establishment or maintenance of cell polarity;GO:0016264,gap junction assembly;GO:0008584,male gonad development;GO:2000146,negative regulation of cell motility;GO:2001240,negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:2001045,negative regulation of integrin-mediated signaling pathway;GO:0007406,negative regulation of neuroblast proliferation;GO:1900181,negative regulation of protein localization to nucleus;GO:0042475,odontogenesis of dentin-containing tooth;GO:0001541,ovarian follicle development;GO:2001241,positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0051149,positive regulation of muscle cell differentiation;GO:0045880,positive regulation of smoothened signaling pathway;GO:0043627,response to estrogen;GO:0048854,brain morphogenesis	hsa:1495,path:hsa04390,Hippo signaling pathway;hsa:1495,path:hsa04520,Adherens junction;hsa:1495,path:hsa04670,Leukocyte transendothelial migration;hsa:1495,path:hsa05200,Pathways in cancer;hsa:1495,path:hsa05226,Gastric cancer;hsa:1495,path:hsa05213,Endometrial cancer;hsa:1495,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:1495,path:hsa05100,Bacterial invasion of epithelial cells
IDHC_HUMAN	O75874	IDH1	Isocitrate dehydrogenase [NADP] cytoplasmic	11.4122623	21.15701466	22.01089954	10.07532261	16.28463848	16.043111075	16.28463848	16.043111075	1.0150548982595	0.428402	0	0.985168390118292	0.428195	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005739,mitochondrion;GO:0005782,peroxisomal matrix;GO:0005777,peroxisome;GO:0034774,secretory granule lumen;GO:1904724,tertiary granule lumen	GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0004450,isocitrate dehydrogenase (NADP+) activity;GO:0000287,magnesium ion binding;GO:0051287,NAD binding;GO:0050661,NADP binding;GO:0042803,protein homodimerization activity;GO:0046872,metal ion binding	GO:0006103,2-oxoglutarate metabolic process;GO:0008585,female gonad development;GO:0006749,glutathione metabolic process;GO:0006097,glyoxylate cycle;GO:0006102,isocitrate metabolic process;GO:0006739,NADP metabolic process;GO:0006740,NADPH regeneration;GO:0043312,neutrophil degranulation;GO:0008104,protein localization;GO:0071071,regulation of phospholipid biosynthetic process;GO:0060696,regulation of phospholipid catabolic process;GO:0006979,response to oxidative stress;GO:0048545,response to steroid hormone;GO:0006099,tricarboxylic acid cycle	hsa:3417,path:hsa00020,Citrate cycle (TCA cycle);hsa:3417,path:hsa00480,Glutathione metabolism;hsa:3417,path:hsa04146,Peroxisome;hsa:3417,path:hsa05230,Central carbon metabolism in cancer
CPSF2_HUMAN	Q9P2I0	CPSF2	Cleavage and polyadenylation specificity factor subunit 2	0.207079418	0.055660256	0.251740622	0.179935044	0.131369837	0.215837833	0.131369837	0.215837833	0.60865064837822	0.324754	0	1.64297861616438	0.325024	0	GO:0016020,membrane;GO:0005847,mRNA cleavage and polyadenylation specificity factor complex;GO:0005654,nucleoplasm	GO:0003723,RNA binding	GO:0031124,mRNA 3'-end processing;GO:0006398,mRNA 3'-end processing by stem-loop binding and cleavage;GO:0006406,mRNA export from nucleus;GO:0006378,mRNA polyadenylation;GO:0000398,mRNA splicing, via spliceosome;GO:0098789,pre-mRNA cleavage required for polyadenylation;GO:0006369,termination of RNA polymerase II transcription;GO:0006379,mRNA cleavage	hsa:53981,path:hsa03015,mRNA surveillance pathway
GUAA_HUMAN	P49915	GMPS	GMP synthase [glutamine-hydrolyzing]	0.638330479	0.569948535	1.274612113	1.33867933	0.604139507	1.3066457215	0.604139507	1.3066457215	0.462359074888686	0.190908	0	2.16282118014176	0.191243	0	GO:0005829,cytosol	GO:0005524,ATP binding;GO:0003922,GMP synthase (glutamine-hydrolyzing) activity;GO:0003921,GMP synthase activity;GO:0016462,pyrophosphatase activity	GO:0006541,glutamine metabolic process;GO:0006177,GMP biosynthetic process;GO:0009113,purine nucleobase biosynthetic process;GO:0009168,purine ribonucleoside monophosphate biosynthetic process	hsa:8833,path:hsa00230,Purine metabolism;hsa:8833,path:hsa00983,Drug metabolism - other enzymes
GTR3_HUMAN	P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	0.193752178	0.09649586	0.158390624	0.200468056	0.145124019	0.17942934	0.145124019	0.17942934	0.808808743319236	0.492043	0	1.23638623872455	0.492143	0	GO:0042995,cell projection;GO:0070062,extracellular exosome;GO:0101003,ficolin-1-rich granule membrane;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0043204,perikaryon;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0035579,specific granule membrane;GO:0070821,tertiary granule membrane	GO:0005536,glucose binding;GO:0005355,glucose transmembrane transporter activity;GO:0022857,transmembrane transporter activity	GO:0005975,carbohydrate metabolic process;GO:0098708,glucose import across plasma membrane;GO:1904659,glucose transmembrane transport;GO:0019852,L-ascorbic acid metabolic process;GO:0043312,neutrophil degranulation;GO:0150104,transport across blood-brain barrier	
SMD2_HUMAN	P62316	SNRPD2	Small nuclear ribonucleoprotein Sm D2	6.783159179	1.583564793	0.317424584	0.503198006	4.183361986	0.410311295	4.183361986	0.410311295	10.1955808601369	0.016796	1	0.0980817094894355	0.016594	-1	GO:0071013,catalytic step 2 spliceosome;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0034709,methylosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0034715,pICln-Sm protein complex;GO:0071011,precatalytic spliceosome;GO:0030532,small nuclear ribonucleoprotein complex;GO:0034719,SMN-Sm protein complex;GO:0005681,spliceosomal complex;GO:0005685,U1 snRNP;GO:0005689,U12-type spliceosomal complex;GO:0005686,U2 snRNP;GO:0071007,U2-type catalytic step 2 spliceosome;GO:0071005,U2-type precatalytic spliceosome;GO:0005687,U4 snRNP;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005682,U5 snRNP	GO:0003723,RNA binding;GO:1990446,U1 snRNP binding	GO:0051170,import into nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0008380,RNA splicing;GO:0000245,spliceosomal complex assembly;GO:0000387,spliceosomal snRNP assembly;GO:0006397,mRNA processing	hsa:6633,path:hsa03040,Spliceosome
LMO7_HUMAN	Q8WWI1	LMO7	LIM domain only protein 7	0.700846472	0.332162849	0.439397912	0.543595132	0.5165046605	0.491496522	0.5165046605	0.491496522	1.05088161844612	0.416959	0	0.951581969317003	0.416727	0	GO:0016324,apical plasma membrane;GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005635,nuclear envelope;GO:0005634,nucleus;GO:0000151,ubiquitin ligase complex;GO:0005912,adherens junction;GO:0005654,nucleoplasm;GO:0016021,integral component of membrane	GO:0046872,metal ion binding;GO:0004842,ubiquitin-protein transferase activity;GO:0042805,actinin binding;GO:0008022,protein C-terminus binding	GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0043687,post-translational protein modification;GO:0000209,protein polyubiquitination;GO:0016567,protein ubiquitination;GO:0030155,regulation of cell adhesion;GO:0023051,regulation of signaling	hsa:4008,path:hsa04520,Adherens junction
RS13_HUMAN	P62277	RPS13	40S ribosomal protein S13	2.844837977	6.488085231	1.331222932	0.775807392	4.666461604	1.053515162	4.666461604	1.053515162	4.42942045099869	0.077476	0	0.225763169485194	0.076998	0	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0014069,postsynaptic density;GO:0005840,ribosome	GO:0048027,mRNA 5'-UTR binding;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0070181,small ribosomal subunit rRNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0033119,negative regulation of RNA splicing;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6207,path:hsa03010,Ribosome
ATG3_HUMAN	Q9NT62	ATG3	Ubiquitin-like-conjugating enzyme ATG3	0.063294589	0.117734014	0.164896615	0.224612092	0.0905143015	0.1947543535	0.0905143015	0.1947543535	0.46476137695171	0.193071	0	2.15164178778975	0.193406	0	GO:0000153,cytoplasmic ubiquitin ligase complex;GO:0005829,cytosol	GO:0019777,Atg12 transferase activity;GO:0019776,Atg8 ligase activity;GO:0019899,enzyme binding;GO:0019787,ubiquitin-like protein transferase activity	GO:0000045,autophagosome assembly;GO:0000422,autophagy of mitochondrion;GO:0044804,autophagy of nucleus;GO:0006464,cellular protein modification process;GO:0016236,macroautophagy;GO:0043653,mitochondrial fragmentation involved in apoptotic process;GO:0050765,negative regulation of phagocytosis;GO:0006612,protein targeting to membrane;GO:0016567,protein ubiquitination;GO:1902017,regulation of cilium assembly	hsa:64422,path:hsa04140,Autophagy - animal;hsa:64422,path:hsa04136,Autophagy - other;hsa:64422,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection
SAMP_HUMAN	P02743	APCS	Serum amyloid P-component	6.933403264	8.403027225	11.61879444	73.935306	7.6682152445	42.77705022	7.6682152445	42.77705022	0.179260028568188	0.010102	-1	5.57848845605654	0.010180	1	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005634,nucleus	GO:0005509,calcium ion binding;GO:0030246,carbohydrate binding;GO:0001849,complement component C1q complex binding;GO:0042802,identical protein binding;GO:0030169,low-density lipoprotein particle binding;GO:0051082,unfolded protein binding;GO:0046790,virion binding	GO:0006953,acute-phase response;GO:1990000,amyloid fibril formation;GO:0051131,chaperone-mediated protein complex assembly;GO:0006958,complement activation, classical pathway;GO:0045087,innate immune response;GO:0044869,negative regulation by host of viral exo-alpha-sialidase activity;GO:0044871,negative regulation by host of viral glycoprotein metabolic process;GO:0044793,negative regulation by host of viral process;GO:0002674,negative regulation of acute inflammatory response;GO:1903016,negative regulation of exo-alpha-sialidase activity;GO:1903019,negative regulation of glycoprotein metabolic process;GO:0045656,negative regulation of monocyte differentiation;GO:0046597,negative regulation of viral entry into host cell;GO:0048525,negative regulation of viral process;GO:0061045,negative regulation of wound healing;GO:0006457,protein folding	
YES_HUMAN	P07947	YES1	Tyrosine-protein kinase Yes	0.064215504	0.078725442	0.076654285	0.236713885	0.071470473	0.156684085	0.071470473	0.156684085	0.456143794055408	0.185330	0	2.19229114378465	0.185666	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0005815,microtubule organizing center;GO:0005886,plasma membrane;GO:0098978,glutamatergic synapse;GO:0099091,postsynaptic specialization, intracellular component	GO:0005524,ATP binding;GO:0019899,enzyme binding;GO:0044325,ion channel binding;GO:0004715,non-membrane spanning protein tyrosine kinase activity;GO:0001784,phosphotyrosine residue binding;GO:0004713,protein tyrosine kinase activity;GO:0005102,signaling receptor binding;GO:0004714,transmembrane receptor protein tyrosine kinase activity;GO:0005154,epidermal growth factor receptor binding	GO:0030154,cell differentiation;GO:0006464,cellular protein modification process;GO:0048013,ephrin receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0045087,innate immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0043114,regulation of vascular permeability;GO:0031295,T cell costimulation;GO:0007169,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0046777,protein autophosphorylation	hsa:7525,path:hsa04520,Adherens junction
CRBG1_HUMAN	Q9Y4K1	CRYBG1	Beta/gamma crystallin domain-containing protein 1	0.049563067	0.059886262	0.092407505	0.059178056	0.0547246645	0.0757927805	0.0547246645	0.0757927805	0.722030042162129	0.423326	0	1.38498392256018	0.423502	0		GO:0030246,carbohydrate binding		
LSM4_HUMAN	Q9Y4Z0	LSM4	U6 snRNA-associated Sm-like protein LSm4	0.235569537	0.182323731	0.040382745	2.55E-05	0.208946634	0.0202041225	0.208946634	0.0202041225	10.3417821783648	0.016301	1	0.0966951326911541	0.016103	-1	GO:0005829,cytosol;GO:0120115,Lsm2-8 complex;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body;GO:0032991,protein-containing complex;GO:0097526,spliceosomal tri-snRNP complex;GO:0071005,U2-type precatalytic spliceosome;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005688,U6 snRNP;GO:0005681,spliceosomal complex	GO:0042731,PH domain binding;GO:0003723,RNA binding;GO:0017070,U6 snRNA binding	GO:0043928,exonucleolytic catabolism of deadenylated mRNA;GO:0000398,mRNA splicing, via spliceosome;GO:0033962,P-body assembly;GO:0008380,RNA splicing;GO:0000387,spliceosomal snRNP assembly;GO:0000956,nuclear-transcribed mRNA catabolic process	hsa:25804,path:hsa03040,Spliceosome;hsa:25804,path:hsa03018,RNA degradation
LGUL_HUMAN	Q04760	GLO1	Lactoylglutathione lyase	4.611974676	13.80733516	0.534176137	0.02332811	9.209654918	0.2787521235	9.209654918	0.2787521235	33.0388690940322	0.000917	1	0.0302673798293123	0.000895	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0004462,lactoylglutathione lyase activity;GO:0008270,zinc ion binding	GO:0005975,carbohydrate metabolic process;GO:0006749,glutathione metabolic process;GO:0009438,methylglyoxal metabolic process;GO:0043066,negative regulation of apoptotic process;GO:0030316,osteoclast differentiation;GO:0006090,pyruvate metabolic process;GO:0006357,regulation of transcription by RNA polymerase II	hsa:2739,path:hsa00620,Pyruvate metabolism
TRXR1_HUMAN	Q16881	TXNRD1	Thioredoxin reductase 1, cytoplasmic	4.472881803	3.435196658	5.919548851	4.482532222	3.9540392305	5.2010405365	3.9540392305	5.2010405365	0.760240033268581	0.454387	0	1.31537403483028	0.454529	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0001650,fibrillar center;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0050660,flavin adenine dinucleotide binding;GO:0015035,protein disulfide oxidoreductase activity;GO:0004791,thioredoxin-disulfide reductase activity;GO:0016668,oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor;GO:0016491,oxidoreductase activity	GO:0008283,cell population proliferation;GO:0045454,cell redox homeostasis;GO:0034599,cellular response to oxidative stress;GO:0001707,mesoderm formation;GO:0015949,nucleobase-containing small molecule interconversion;GO:0019222,regulation of metabolic process;GO:0001887,selenium compound metabolic process;GO:0007165,signal transduction	hsa:7296,path:hsa00450,Selenocompound metabolism;hsa:7296,path:hsa05200,Pathways in cancer;hsa:7296,path:hsa05225,Hepatocellular carcinoma
SELB_HUMAN	P57772	EEFSEC	Selenocysteine-specific elongation factor	3.040698045	0.980794623	3.162088764	0.739275556	2.010746334	1.95068216	2.010746334	1.95068216	1.03079136890246	0.423319	0	0.970128417998648	0.423101	0	GO:0005737,cytoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0043021,ribonucleoprotein complex binding;GO:0035368,selenocysteine insertion sequence binding;GO:0003746,translation elongation factor activity;GO:0000049,tRNA binding	GO:0001514,selenocysteine incorporation;GO:0006414,translational elongation	
ECI1_HUMAN	P42126	ECI1	Enoyl-CoA delta isomerase 1, mitochondrial	1.99449939	1.078021705	2.207483163	1.78770451	1.5362605475	1.9975938365	1.5362605475	1.9975938365	0.769055510399298	0.461376	0	1.30029625492286	0.461511	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0004165,dodecenoyl-CoA delta-isomerase activity;GO:0004300,enoyl-CoA hydratase activity;GO:0016863,intramolecular oxidoreductase activity, transposing C=C bonds;GO:0016853,isomerase activity;GO:0003824,catalytic activity	GO:0006635,fatty acid beta-oxidation	hsa:1632,path:hsa00071,Fatty acid degradation
LAMA1_HUMAN	P25391	LAMA1	Laminin subunit alpha-1	0.105646601	0.13328356	0.162284424	0.665217721	0.1194650805	0.4137510725	0.1194650805	0.4137510725	0.288736606235625	0.055459	0	3.46336411249478	0.055690	0	GO:0005604,basement membrane;GO:0005911,cell-cell junction;GO:0062023,collagen-containing extracellular matrix;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005606,laminin-1 complex;GO:0005608,laminin-3 complex;GO:0016020,membrane	GO:0005201,extracellular matrix structural constituent;GO:0043208,glycosphingolipid binding;GO:0008022,protein C-terminus binding;GO:0005102,signaling receptor binding	GO:0009887,animal organ morphogenesis;GO:0007411,axon guidance;GO:0048514,blood vessel morphogenesis;GO:0060445,branching involved in salivary gland morphogenesis;GO:0043010,camera-type eye development;GO:0007155,cell adhesion;GO:0007166,cell surface receptor signaling pathway;GO:0060441,epithelial tube branching involved in lung morphogenesis;GO:0045198,establishment of epithelial cell apical/basal polarity;GO:0030198,extracellular matrix organization;GO:0002011,morphogenesis of an epithelial sheet;GO:0006468,protein phosphorylation;GO:0030155,regulation of cell adhesion;GO:0030334,regulation of cell migration;GO:0045995,regulation of embryonic development;GO:0061304,retinal blood vessel morphogenesis;GO:0009888,tissue development	hsa:284217,path:hsa04151,PI3K-Akt signaling pathway;hsa:284217,path:hsa04512,ECM-receptor interaction;hsa:284217,path:hsa04510,Focal adhesion;hsa:284217,path:hsa05200,Pathways in cancer;hsa:284217,path:hsa05222,Small cell lung cancer;hsa:284217,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:284217,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:284217,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:284217,path:hsa05416,Viral myocarditis;hsa:284217,path:hsa05165,Human papillomavirus infection;hsa:284217,path:hsa05146,Amoebiasis;hsa:284217,path:hsa05145,Toxoplasmosis
TBL2_HUMAN	Q9Y4P3	TBL2	Transducin beta-like protein 2	1.092486567	0.592995063	1.559039645	0.703906575	0.842740815	1.13147311	0.842740815	1.13147311	0.74481736026409	0.441997	0	1.34261102566867	0.442153	0	GO:0005783,endoplasmic reticulum;GO:0030176,integral component of endoplasmic reticulum membrane	GO:0051219,phosphoprotein binding;GO:0019901,protein kinase binding;GO:0003723,RNA binding;GO:0031369,translation initiation factor binding	GO:0042149,cellular response to glucose starvation;GO:0071456,cellular response to hypoxia;GO:0030968,endoplasmic reticulum unfolded protein response	
STT3B_HUMAN	Q8TCJ2	STT3B	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B	5.119190915	3.639776216	5.239043871	14.48737023	4.3794835655	9.8632070505	4.3794835655	9.8632070505	0.444022268119981	0.174534	0	2.25213929975644	0.174870	0	GO:0005783,endoplasmic reticulum;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0008250,oligosaccharyltransferase complex;GO:0034998,oligosaccharyltransferase I complex;GO:0032991,protein-containing complex	GO:0004579,dolichyl-diphosphooligosaccharide-protein glycotransferase activity;GO:0046872,metal ion binding	GO:0043686,co-translational protein modification;GO:0006516,glycoprotein catabolic process;GO:0043687,post-translational protein modification;GO:0006487,protein N-linked glycosylation;GO:0018279,protein N-linked glycosylation via asparagine;GO:0006986,response to unfolded protein;GO:0030433,ubiquitin-dependent ERAD pathway	hsa:201595,path:hsa00510,N-Glycan biosynthesis;hsa:201595,path:hsa00513,Various types of N-glycan biosynthesis;hsa:201595,path:hsa04141,Protein processing in endoplasmic reticulum
CSN1_HUMAN	Q13098	GPS1	COP9 signalosome complex subunit 1	0.619429011	0.594538081	0.994558692	1.127784397	0.606983546	1.0611715445	0.606983546	1.0611715445	0.571993801705262	0.291375	0	1.74827069282698	0.291669	0	GO:0008180,COP9 signalosome;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005737,cytoplasm	GO:0005095,GTPase inhibitor activity	GO:0000188,inactivation of MAPK activity;GO:0007254,JNK cascade;GO:0000715,nucleotide-excision repair, DNA damage recognition;GO:0043687,post-translational protein modification;GO:0000338,protein deneddylation;GO:0006283,transcription-coupled nucleotide-excision repair	
RM48_HUMAN	Q96GC5	MRPL48	39S ribosomal protein L48, mitochondrial	0.18217905	0.136885197	0.015618034	0.033498591	0.1595321235	0.0245583125	0.1595321235	0.0245583125	6.49605397357819	0.040492	1	0.153939607655257	0.040143	-1	GO:0005743,mitochondrial inner membrane;GO:0005762,mitochondrial large ribosomal subunit;GO:0005761,mitochondrial ribosome;GO:0005739,mitochondrion		GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination	
KVD24_HUMAN	A0A075B6R9	IGKV2D-24	Probable non-functional immunoglobulin kappa variable 2D-24	4.251966338	1.294326308	2.306144535	6.951037535	2.773146323	4.628591035	2.773146323	4.628591035	0.59913401335964	0.316137	0	1.6690756620418	0.316413	0	GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region	GO:0003823,antigen binding	GO:0002250,adaptive immune response;GO:0006955,immune response;GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response	
FXYD3_HUMAN	Q14802	FXYD3	FXYD domain-containing ion transport regulator 3	0.138167542	0.228830702	0.157932955	2.55E-05	0.183499122	0.0789792275	0.183499122	0.0789792275	2.32338461401132	0.189862	0	0.430406568920804	0.189297	0	GO:0070062,extracellular exosome;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0005254,chloride channel activity;GO:0099106,ion channel regulator activity;GO:0017080,sodium channel regulator activity	GO:0006821,chloride transport;GO:0034220,ion transmembrane transport;GO:0006813,potassium ion transport;GO:1903779,regulation of cardiac conduction;GO:2000649,regulation of sodium ion transmembrane transporter activity;GO:0006814,sodium ion transport;GO:0006811,ion transport;GO:0043269,regulation of ion transport	
PGH2_HUMAN	P35354	PTGS2	Prostaglandin G/H synthase 2	1.175595217	0.149066607	0.362956676	0.380470914	0.662330912	0.371713795	0.662330912	0.371713795	1.78183032459153	0.256324	0	0.561220665177107	0.255813	0	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0043005,neuron projection;GO:0005637,nuclear inner membrane;GO:0005640,nuclear outer membrane	GO:0051213,dioxygenase activity;GO:0019899,enzyme binding;GO:0020037,heme binding;GO:0046872,metal ion binding;GO:0004601,peroxidase activity;GO:0004666,prostaglandin-endoperoxide synthase activity	GO:0071456,cellular response to hypoxia;GO:0019371,cyclooxygenase pathway;GO:0019221,cytokine-mediated signaling pathway;GO:0006954,inflammatory response;GO:0019372,lipoxygenase pathway;GO:0042759,long-chain fatty acid biosynthetic process;GO:0034356,NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0090336,positive regulation of brown fat cell differentiation;GO:0090050,positive regulation of cell migration involved in sprouting angiogenesis;GO:0031622,positive regulation of fever generation;GO:0090271,positive regulation of fibroblast growth factor production;GO:0045429,positive regulation of nitric oxide biosynthetic process;GO:0090362,positive regulation of platelet-derived growth factor production;GO:0031394,positive regulation of prostaglandin biosynthetic process;GO:0071636,positive regulation of transforming growth factor beta production;GO:0010575,positive regulation of vascular endothelial growth factor production;GO:0001516,prostaglandin biosynthetic process;GO:0008217,regulation of blood pressure;GO:0050727,regulation of inflammatory response;GO:0150077,regulation of neuroinflammatory response;GO:0006979,response to oxidative stress	hsa:5743,path:hsa00590,Arachidonic acid metabolism;hsa:5743,path:hsa04370,VEGF signaling pathway;hsa:5743,path:hsa04064,NF-kappa B signaling pathway;hsa:5743,path:hsa04668,TNF signaling pathway;hsa:5743,path:hsa04625,C-type lectin receptor signaling pathway;hsa:5743,path:hsa04657,IL-17 signaling pathway;hsa:5743,path:hsa04923,Regulation of lipolysis in adipocytes;hsa:5743,path:hsa04913,Ovarian steroidogenesis;hsa:5743,path:hsa04921,Oxytocin signaling pathway;hsa:5743,path:hsa04726,Serotonergic synapse;hsa:5743,path:hsa04723,Retrograde endocannabinoid signaling;hsa:5743,path:hsa05200,Pathways in cancer;hsa:5743,path:hsa05206,MicroRNAs in cancer;hsa:5743,path:hsa05204,Chemical carcinogenesis;hsa:5743,path:hsa05222,Small cell lung cancer;hsa:5743,path:hsa05163,Human cytomegalovirus infection;hsa:5743,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:5743,path:hsa05165,Human papillomavirus infection;hsa:5743,path:hsa05140,Leishmaniasis
HYOU1_HUMAN	Q9Y4L1	HYOU1	Hypoxia up-regulated protein 1	15.73654058	4.274908501	16.79018977	9.097882559	10.0057245405	12.9440361645	10.0057245405	12.9440361645	0.772998809130452	0.464481	0	1.29366305379552	0.464612	0	GO:0071682,endocytic vesicle lumen;GO:0005783,endoplasmic reticulum;GO:0034663,endoplasmic reticulum chaperone complex;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005790,smooth endoplasmic reticulum	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0051087,chaperone binding;GO:0051082,unfolded protein binding	GO:0071456,cellular response to hypoxia;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0036498,IRE1-mediated unfolded protein response;GO:1903298,negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway;GO:0006898,receptor-mediated endocytosis;GO:0034976,response to endoplasmic reticulum stress;GO:0002931,response to ischemia;GO:1903382,negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	hsa:10525,path:hsa04141,Protein processing in endoplasmic reticulum
IGHG2_HUMAN	P01859	IGHG2	Immunoglobulin heavy constant gamma 2	13.60032475	16.91071431	29.90272747	74.89302778	15.25551953	52.397877625	15.25551953	52.397877625	0.291147661345759	0.056896	0	3.43468326476588	0.057130	0	GO:0072562,blood microparticle;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0042571,immunoglobulin complex, circulating;GO:0016021,integral component of membrane	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0045087,innate immune response;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0030449,regulation of complement activation	
BPNT1_HUMAN	O95861	BPNT1	3'(2'),5'-bisphosphate nucleotidase 1	1.56653378	1.164144927	2.196263833	0.613385688	1.3653393535	1.4048247605	1.3653393535	1.4048247605	0.971893001810456	0.442822	0	1.02891984831374	0.442645	0	GO:0005829,cytosol	GO:0008441,3'(2'),5'-bisphosphate nucleotidase activity;GO:0046872,metal ion binding	GO:0050427,3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0046855,inositol phosphate dephosphorylation;GO:0007399,nervous system development;GO:0006139,nucleobase-containing compound metabolic process;GO:0046854,phosphatidylinositol phosphorylation	hsa:10380,path:hsa00920,Sulfur metabolism
CHERP_HUMAN	Q8IWX8	CHERP	Calcium homeostasis endoplasmic reticulum protein	0.480784111	0.387299949	0.563411553	0.910688313	0.43404203	0.737049933	0.43404203	0.737049933	0.588890942888126	0.306821	0	1.69810728467932	0.307105	0	GO:0005737,cytoplasm;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm;GO:0033017,sarcoplasmic reticulum membrane	GO:0044325,ion channel binding;GO:0003723,RNA binding	GO:0006874,cellular calcium ion homeostasis;GO:0000398,mRNA splicing, via spliceosome;GO:0008285,negative regulation of cell population proliferation;GO:0007399,nervous system development;GO:0070886,positive regulation of calcineurin-NFAT signaling cascade;GO:0051209,release of sequestered calcium ion into cytosol;GO:0006396,RNA processing	hsa:10523,path:hsa03040,Spliceosome
HPTR_HUMAN	P00739	HPR	Haptoglobin-related protein	0.065955815	0.033321347	0.108763822	0.855032973	0.049638581	0.4818983975	0.049638581	0.4818983975	0.103006320953786	0.000764	-1	9.70814209012139	0.000774	1	GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0034366,spherical high-density lipoprotein particle	GO:0030492,hemoglobin binding;GO:0004252,serine-type endopeptidase activity	GO:0002526,acute inflammatory response;GO:0010942,positive regulation of cell death;GO:0006898,receptor-mediated endocytosis;GO:0031638,zymogen activation	hsa:3250,path:hsa05143,African trypanosomiasis
LBR_HUMAN	Q14739	LBR	Delta(14)-sterol reductase LBR	1.133449097	1.330259838	2.259119689	1.129086148	1.2318544675	1.6941029185	1.2318544675	1.6941029185	0.727142639356713	0.427552	0	1.37524599146693	0.427724	0	GO:0005737,cytoplasm;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0005639,integral component of nuclear inner membrane;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0005637,nuclear inner membrane;GO:0031965,nuclear membrane;GO:0005634,nucleus	GO:0070087,chromo shadow domain binding;GO:0050613,delta14-sterol reductase activity;GO:0003677,DNA binding;GO:0005521,lamin binding;GO:0070402,NADPH binding;GO:0016627,oxidoreductase activity, acting on the CH-CH group of donors;GO:0003723,RNA binding	GO:0006695,cholesterol biosynthetic process;GO:0007084,mitotic nuclear envelope reassembly;GO:0030223,neutrophil differentiation;GO:0016126,sterol biosynthetic process	hsa:3930,path:hsa00100,Steroid biosynthesis
PCYXL_HUMAN	Q8NBM8	PCYOX1L	Prenylcysteine oxidase-like	0.052913232	0.053180614	0.047968786	0.082431586	0.053046923	0.065200186	0.053046923	0.065200186	0.813600792488537	0.495644	0	1.22910401419513	0.495740	0	GO:0005576,extracellular region;GO:0016020,membrane;GO:0031093,platelet alpha granule lumen	GO:0001735,prenylcysteine oxidase activity	GO:0002576,platelet degranulation;GO:0030327,prenylated protein catabolic process;GO:0030328,prenylcysteine catabolic process	
HNRPR_HUMAN	O43390	HNRNPR	Heterogeneous nuclear ribonucleoprotein R	2.745037166	5.835345008	3.158692855	2.441405308	4.290191087	2.8000490815	4.290191087	2.8000490815	1.53218424467821	0.298925	0	0.652663022396513	0.298473	0	GO:0043679,axon terminus;GO:0071013,catalytic step 2 spliceosome;GO:0030425,dendrite;GO:0005783,endoplasmic reticulum;GO:0030426,growth cone;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0005681,spliceosomal complex	GO:0003730,mRNA 3'-UTR binding;GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0007623,circadian rhythm;GO:0061157,mRNA destabilization;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0043086,negative regulation of catalytic activity;GO:0016070,RNA metabolic process	
ANX11_HUMAN	P50995	ANXA11	Annexin A11	10.05162411	12.95520875	14.21082592	16.01343679	11.50341643	15.112131355	11.50341643	15.112131355	0.761204105481387	0.455154	0	1.31370810115061	0.455296	0	GO:0042582,azurophil granule;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0042470,melanosome;GO:0016020,membrane;GO:0030496,midbody;GO:0005635,nuclear envelope;GO:0005654,nucleoplasm;GO:0045335,phagocytic vesicle;GO:0042581,specific granule;GO:0005819,spindle	GO:0005509,calcium ion binding;GO:0005544,calcium-dependent phospholipid binding;GO:0048306,calcium-dependent protein binding;GO:0023026,MHC class II protein complex binding;GO:0003723,RNA binding;GO:0044548,S100 protein binding	GO:0032506,cytokinetic process;GO:0006909,phagocytosis;GO:0051592,response to calcium ion	
TM41A_HUMAN	Q96HV5	TMEM41A	Transmembrane protein 41A	0.38671062	0.133847284	0.133045337	0.040319487	0.260278952	0.086682412	0.260278952	0.086682412	3.00267316050227	0.136851	0	0.333036579922913	0.136288	0	GO:0016021,integral component of membrane			
SCRN1_HUMAN	Q12765	SCRN1	Secernin-1	0.135882458	0.207113808	0.389468243	1.881026556	0.171498133	1.1352473995	0.171498133	1.1352473995	0.151066748160386	0.004882	-1	6.61959042726139	0.004928	1	GO:0005737,cytoplasm;GO:0031965,nuclear membrane;GO:0005634,nucleus	GO:0070004,cysteine-type exopeptidase activity;GO:0016805,dipeptidase activity	GO:0006887,exocytosis	
PSB6_HUMAN	P28072	PSMB6	Proteasome subunit beta type-6	4.470131827	5.939414607	1.390404819	0.132428	5.204773217	0.7614164095	5.204773217	0.7614164095	6.83564624042949	0.036891	1	0.146291947363439	0.036560	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000502,proteasome complex;GO:0005839,proteasome core complex;GO:0019774,proteasome core complex, beta-subunit complex	GO:0045296,cadherin binding;GO:0004175,endopeptidase activity;GO:0004298,threonine-type endopeptidase activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0051603,proteolysis involved in cellular protein catabolic process	hsa:5694,path:hsa03050,Proteasome
AK1BA_HUMAN	O60218	AKR1B10	Aldo-keto reductase family 1 member B10	0.759430725	11.09362747	7.59994424	1.036124993	5.9265290975	4.3180346165	5.9265290975	4.3180346165	1.3725061570497	0.331879	0	0.728594181427623	0.331481	0	GO:0005829,cytosol;GO:0005576,extracellular region;GO:0005764,lysosome;GO:0005739,mitochondrion	GO:0008106,alcohol dehydrogenase (NADP+) activity;GO:0004032,alditol;GO:0004033,aldo-keto reductase (NADP) activity;GO:0047655,allyl-alcohol dehydrogenase activity;GO:0047834,D-threo-aldose 1-dehydrogenase activity;GO:0045550,geranylgeranyl reductase activity;GO:0047718,indanol dehydrogenase activity;GO:0052650,NADP-retinol dehydrogenase activity;GO:0001758,retinal dehydrogenase activity	GO:0110095,cellular detoxification of aldehyde;GO:0044597,daunorubicin metabolic process;GO:0044598,doxorubicin metabolic process;GO:0016488,farnesol catabolic process;GO:0001523,retinoid metabolic process	hsa:57016,path:hsa00040,Pentose and glucuronate interconversions;hsa:57016,path:hsa00051,Fructose and mannose metabolism;hsa:57016,path:hsa00052,Galactose metabolism;hsa:57016,path:hsa00561,Glycerolipid metabolism;hsa:57016,path:hsa00790,Folate biosynthesis
TMM33_HUMAN	P57088	TMEM33	Transmembrane protein 33	1.869167686	5.369847729	0.422835258	0.687935321	3.6195077075	0.5553852895	3.6195077075	0.5553852895	6.51711123058113	0.040255	1	0.153442217666558	0.039907	-1	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0042470,melanosome;GO:0005635,nuclear envelope;GO:0016021,integral component of membrane		GO:0071786,endoplasmic reticulum tubular network organization;GO:0061024,membrane organization;GO:1903896,positive regulation of IRE1-mediated unfolded protein response;GO:1903899,positive regulation of PERK-mediated unfolded protein response;GO:1903371,regulation of endoplasmic reticulum tubular network organization;GO:0034976,response to endoplasmic reticulum stress	
TBB4A_HUMAN	P04350	TUBB4A	Tubulin beta-4A chain	0.271691695	0.23918041	0.626635741	2.55E-05	0.2554360525	0.3133306205	0.2554360525	0.3133306205	0.815228502379965	0.496863	0	1.2266499479356	0.496957	0	GO:0005930,axoneme;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0033269,internode region of axon;GO:0005874,microtubule;GO:0043209,myelin sheath;GO:0043025,neuronal cell body;GO:0005634,nucleus	GO:0005509,calcium ion binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0005200,structural constituent of cytoskeleton	GO:0097711,ciliary basal body-plasma membrane docking;GO:0000086,G2/M transition of mitotic cell cycle;GO:0000226,microtubule cytoskeleton organization;GO:0000278,mitotic cell cycle;GO:0031115,negative regulation of microtubule polymerization;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0007017,microtubule-based process	hsa:10382,path:hsa04145,Phagosome;hsa:10382,path:hsa04540,Gap junction;hsa:10382,path:hsa05130,Pathogenic Escherichia coli infection
DMBT1_HUMAN	Q9UGM3	DMBT1	Deleted in malignant brain tumors 1 protein	0.014714148	0.351058186	1.11087778	0.355753795	0.182886167	0.7333157875	0.182886167	0.7333157875	0.249396194814638	0.034538	-1	4.00968427262189	0.034715	1	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0019898,extrinsic component of membrane;GO:0030670,phagocytic vesicle membrane;GO:0042589,zymogen granule membrane;GO:0016020,membrane	GO:0048306,calcium-dependent protein binding;GO:0003677,DNA binding;GO:0050840,extracellular matrix binding;GO:1904399,heparan sulfate binding;GO:0001530,lipopolysaccharide binding;GO:0070891,lipoteichoic acid binding;GO:0038187,pattern recognition receptor activity;GO:0005044,scavenger receptor activity;GO:0035375,zymogen binding	GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0044267,cellular protein metabolic process;GO:0006952,defense response;GO:0050829,defense response to Gram-negative bacterium;GO:0050830,defense response to Gram-positive bacterium;GO:0051607,defense response to virus;GO:0042494,detection of bacterial lipoprotein;GO:0030855,epithelial cell differentiation;GO:0043152,induction of bacterial agglutination;GO:0045087,innate immune response;GO:0007275,multicellular organism development;GO:0015031,protein transport;GO:0006898,receptor-mediated endocytosis;GO:0016032,viral process;GO:0030154,cell differentiation	hsa:1755,path:hsa04970,Salivary secretion
CAZA2_HUMAN	P47755	CAPZA2	F-actin-capping protein subunit alpha-2	3.082277905	2.510551029	4.380973053	4.476468359	2.796414467	4.428720706	2.796414467	4.428720706	0.6314271440083	0.345204	0	1.58371398741587	0.345456	0	GO:0015629,actin cytoskeleton;GO:0005903,brush border;GO:0030863,cortical cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0008290,F-actin capping protein complex;GO:0016020,membrane;GO:0016021,integral component of membrane	GO:0051015,actin filament binding;GO:0003779,actin binding	GO:0030036,actin cytoskeleton organization;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0051016,barbed-end actin filament capping;GO:0007596,blood coagulation;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0045087,innate immune response;GO:0065003,protein-containing complex assembly	hsa:830,path:hsa04144,Endocytosis
SRSF7_HUMAN	Q16629	SRSF7	Serine/arginine-rich splicing factor 7	6.700513294	7.237722039	4.439295973	2.188385878	6.9691176665	3.3138409255	6.9691176665	3.3138409255	2.10303325451522	0.213476	0	0.475503655423896	0.212924	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0019904,protein domain specific binding;GO:0003723,RNA binding;GO:0008270,zinc ion binding;GO:0003676,nucleic acid binding	GO:1990830,cellular response to leukemia inhibitory factor;GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0048025,negative regulation of mRNA splicing, via spliceosome;GO:0006405,RNA export from nucleus;GO:0008380,RNA splicing	hsa:6432,path:hsa03040,Spliceosome;hsa:6432,path:hsa05168,Herpes simplex virus 1 infection
RS10_HUMAN	P46783	RPS10	40S ribosomal protein S10	8.291094312	9.25427453	0.975210096	0.502676112	8.772684421	0.738943104	8.772684421	0.738943104	11.8719348939211	0.012122	1	0.084232267859895	0.011960	-1	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome;GO:0016787,hydrolase activity	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000028,ribosomal small subunit assembly;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6204,path:hsa03010,Ribosome;hsa:100529239,path:hsa03010,Ribosome
MPRIP_HUMAN	Q6WCQ1	MPRIP	Myosin phosphatase Rho-interacting protein	0.134835316	0.138250132	0.134316383	0.192366517	0.136542724	0.16334145	0.136542724	0.16334145	0.835934320406731	0.493297	0	1.19626623239185	0.493232	0	GO:0015629,actin cytoskeleton;GO:0005829,cytosol;GO:0005925,focal adhesion	GO:0051015,actin filament binding;GO:0045296,cadherin binding	GO:0007015,actin filament organization	
DPYL2_HUMAN	Q16555	DPYSL2	Dihydropyrimidinase-related protein 2	24.76705968	44.16076203	32.55333143	62.09999515	34.463910855	47.32666329	34.463910855	47.32666329	0.728213409929581	0.428435	0	1.37322381923275	0.428605	0	GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005886,plasma membrane;GO:0030425,dendrite;GO:0030426,growth cone;GO:0043209,myelin sheath;GO:0043025,neuronal cell body;GO:0032991,protein-containing complex;GO:0043195,terminal bouton	GO:0004157,dihydropyrimidinase activity;GO:0042802,identical protein binding;GO:0008017,microtubule binding;GO:0016810,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0019901,protein kinase binding	GO:0007411,axon guidance;GO:0007420,brain development;GO:0007010,cytoskeleton organization;GO:0006897,endocytosis;GO:0007399,nervous system development;GO:0006139,nucleobase-containing compound metabolic process;GO:0030516,regulation of axon extension;GO:0045664,regulation of neuron differentiation;GO:0007165,signal transduction;GO:0021772,olfactory bulb development;GO:0014049,positive regulation of glutamate secretion;GO:0010975,regulation of neuron projection development;GO:0001975,response to amphetamine;GO:0042220,response to cocaine;GO:0042493,response to drug;GO:0021510,spinal cord development;GO:0048489,synaptic vesicle transport	hsa:1808,path:hsa04360,Axon guidance
RL6_HUMAN	Q02878	RPL6	60S ribosomal protein L6	4.404829546	9.821492461	1.329488331	0.545712016	7.1131610035	0.9376001735	7.1131610035	0.9376001735	7.58656109986311	0.030341	1	0.131812027457084	0.030046	-1	GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005634,nucleus;GO:0042788,polysomal ribosome;GO:0014069,postsynaptic density;GO:0005791,rough endoplasmic reticulum;GO:0005840,ribosome	GO:0045296,cadherin binding;GO:0003677,DNA binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006355,regulation of transcription, DNA-templated;GO:0000027,ribosomal large subunit assembly;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6128,path:hsa03010,Ribosome
AGO1_HUMAN	Q9UL18	AGO1	Protein argonaute-1	1.918460318	1.735673527	2.200369389	3.32022506	1.8270669225	2.7602972245	1.8270669225	2.7602972245	0.661909487964998	0.372117	0	1.51078057979565	0.372345	0	GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body;GO:0005844,polysome;GO:1990904,ribonucleoprotein complex;GO:0016442,RISC complex;GO:0070578,RISC-loading complex	GO:0001046,core promoter sequence-specific DNA binding;GO:0003725,double-stranded RNA binding;GO:0035198,miRNA binding;GO:0003723,RNA binding;GO:0000993,RNA polymerase II complex binding;GO:0003727,single-stranded RNA binding	GO:0030522,intracellular receptor signaling pathway;GO:0035280,miRNA loading onto RISC involved in gene silencing by miRNA;GO:0035278,miRNA mediated inhibition of translation;GO:0016525,negative regulation of angiogenesis;GO:0010629,negative regulation of gene expression;GO:0000956,nuclear-transcribed mRNA catabolic process;GO:0010628,positive regulation of gene expression;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0035194,post-transcriptional gene silencing by RNA;GO:0031054,pre-miRNA processing;GO:0035196,production of miRNAs involved in gene silencing by miRNA;GO:0060964,regulation of gene silencing by miRNA;GO:0045652,regulation of megakaryocyte differentiation;GO:0060260,regulation of transcription initiation from RNA polymerase II promoter;GO:0090502,RNA phosphodiester bond hydrolysis, endonucleolytic;GO:0010501,RNA secondary structure unwinding;GO:0007223,Wnt signaling pathway, calcium modulating pathway;GO:0031047,gene silencing by RNA;GO:0006417,regulation of translation	
RAB3A_HUMAN	P20336	RAB3A	Ras-related protein Rab-3A	0.044421687	0.062374086	2.55E-05	2.55E-05	0.0533978865	2.55e-005	0.0533978865	2.55e-005	2094.03476470588	0.000000	1	0.000477546990553643	0.000000	-1	GO:0001669,acrosomal vesicle;GO:0098993,anchored component of synaptic vesicle membrane;GO:0030424,axon;GO:0060201,clathrin-sculpted acetylcholine transport vesicle membrane;GO:0061202,clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane;GO:0060203,clathrin-sculpted glutamate transport vesicle membrane;GO:0070083,clathrin-sculpted monoamine transport vesicle membrane;GO:0005829,cytosol;GO:0005768,endosome;GO:1903561,extracellular vesicle;GO:0005764,lysosome;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0048786,presynaptic active zone;GO:0032991,protein-containing complex;GO:0030667,secretory granule membrane;GO:0008021,synaptic vesicle;GO:0043195,terminal bouton	GO:0001671,ATPase activator activity;GO:0051117,ATPase binding;GO:0051021,GDP-dissociation inhibitor binding;GO:0005525,GTP binding;GO:0030742,GTP-dependent protein binding;GO:0003924,GTPase activity;GO:0031489,myosin V binding;GO:0008022,protein C-terminus binding	GO:0060478,acrosomal vesicle exocytosis;GO:0007409,axonogenesis;GO:0045054,constitutive secretory pathway;GO:0061670,evoked neurotransmitter secretion;GO:0006887,exocytosis;GO:0030324,lung development;GO:0032418,lysosome localization;GO:0048790,maintenance of presynaptic active zone structure;GO:0007005,mitochondrion organization;GO:0007274,neuromuscular synaptic transmission;GO:0007269,neurotransmitter secretion;GO:0006836,neurotransmitter transport;GO:0043312,neutrophil degranulation;GO:0001778,plasma membrane repair;GO:0045921,positive regulation of exocytosis;GO:1903307,positive regulation of regulated secretory pathway;GO:0009791,post-embryonic development;GO:0043687,post-translational protein modification;GO:0072659,protein localization to plasma membrane;GO:0009306,protein secretion;GO:0045055,regulated exocytosis;GO:0014059,regulation of dopamine secretion;GO:0017157,regulation of exocytosis;GO:1905684,regulation of plasma membrane repair;GO:0048172,regulation of short-term neuronal synaptic plasticity;GO:2000300,regulation of synaptic vesicle exocytosis;GO:0031630,regulation of synaptic vesicle fusion to presynaptic active zone membrane;GO:0010807,regulation of synaptic vesicle priming;GO:0003016,respiratory system process;GO:0051602,response to electrical stimulus;GO:0050975,sensory perception of touch;GO:0097091,synaptic vesicle clustering;GO:0016079,synaptic vesicle exocytosis;GO:0016188,synaptic vesicle maturation;GO:0036465,synaptic vesicle recycling;GO:0048489,synaptic vesicle transport;GO:0006904,vesicle docking involved in exocytosis	hsa:5864,path:hsa04911,Insulin secretion;hsa:5864,path:hsa04721,Synaptic vesicle cycle
INT1_HUMAN	Q8N201	INTS1	Integrator complex subunit 1	0.212712978	0.092944536	0.270704836	0.222882048	0.152828757	0.246793442	0.152828757	0.246793442	0.619257771849545	0.334310	0	1.61483641458917	0.334572	0	GO:0016021,integral component of membrane;GO:0032039,integrator complex;GO:0016020,membrane;GO:0031965,nuclear membrane;GO:0005654,nucleoplasm		GO:0016180,snRNA processing;GO:0042795,snRNA transcription by RNA polymerase II;GO:0034474,U2 snRNA 3'-end processing	
PIMT_HUMAN	P22061	PCMT1	Protein-L-isoaspartate(D-aspartate) O-methyltransferase	0.77619538	1.136914111	2.477913518	2.998120249	0.9565547455	2.7380168835	0.9565547455	2.7380168835	0.349360426250271	0.096318	0	2.86237342544238	0.096613	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:1903561,extracellular vesicle	GO:0045296,cadherin binding;GO:0004719,protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	GO:0006479,protein methylation;GO:0030091,protein repair	
VA0D1_HUMAN	P61421	ATP6V0D1	V-type proton ATPase subunit d 1	3.067057516	1.134335646	4.107774052	5.248676575	2.100696581	4.6782253135	2.100696581	4.6782253135	0.449037068594794	0.178986	0	2.22698763629777	0.179322	0	GO:0005769,early endosome;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0030670,phagocytic vesicle membrane;GO:0033181,plasma membrane proton-transporting V-type ATPase complex;GO:0033179,proton-transporting V-type ATPase, V0 domain;GO:0016471,vacuolar proton-transporting V-type ATPase complex;GO:0016324,apical plasma membrane;GO:0043679,axon terminus;GO:0008021,synaptic vesicle	GO:0046961,proton-transporting ATPase activity, rotational mechanism;GO:0015078,proton transmembrane transporter activity;GO:0044877,protein-containing complex binding	GO:0006879,cellular iron ion homeostasis;GO:0034198,cellular response to amino acid starvation;GO:0036295,cellular response to increased oxygen levels;GO:0060271,cilium assembly;GO:0008286,insulin receptor signaling pathway;GO:0034220,ion transmembrane transport;GO:0036498,IRE1-mediated unfolded protein response;GO:0090383,phagosome acidification;GO:1902600,proton transmembrane transport;GO:0016241,regulation of macroautophagy;GO:0033572,transferrin transport;GO:0007035,vacuolar acidification;GO:0007034,vacuolar transport;GO:0007420,brain development	hsa:9114,path:hsa00190,Oxidative phosphorylation;hsa:9114,path:hsa04145,Phagosome;hsa:9114,path:hsa04142,Lysosome;hsa:9114,path:hsa04966,Collecting duct acid secretion;hsa:9114,path:hsa04721,Synaptic vesicle cycle;hsa:9114,path:hsa05203,Viral carcinogenesis;hsa:9114,path:hsa05323,Rheumatoid arthritis;hsa:9114,path:hsa05110,Vibrio cholerae infection;hsa:9114,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:9114,path:hsa05152,Tuberculosis;hsa:9114,path:hsa05165,Human papillomavirus infection
STXB1_HUMAN	P61764	STXBP1	Syntaxin-binding protein 1	0.218512682	0.157578207	0.284168678	0.543058207	0.1880454445	0.4136134425	0.1880454445	0.4136134425	0.454640553661406	0.183985	0	2.19953981655748	0.184321	0	GO:0030424,axon;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm;GO:0045335,phagocytic vesicle;GO:0005886,plasma membrane;GO:0031091,platelet alpha granule;GO:0098794,postsynapse;GO:0048787,presynaptic active zone membrane;GO:0032991,protein-containing complex;GO:0030141,secretory granule	GO:0042802,identical protein binding;GO:0043274,phospholipase binding;GO:0019904,protein domain specific binding;GO:0019901,protein kinase binding;GO:0047485,protein N-terminus binding;GO:0003723,RNA binding;GO:0000149,SNARE binding;GO:0019905,syntaxin binding;GO:0017075,syntaxin-1 binding	GO:0007412,axon target recognition;GO:0071346,cellular response to interferon-gamma;GO:0003006,developmental process involved in reproduction;GO:0006886,intracellular protein transport;GO:0060292,long-term synaptic depression;GO:0043524,negative regulation of neuron apoptotic process;GO:0031333,negative regulation of protein-containing complex assembly;GO:0032229,negative regulation of synaptic transmission, GABAergic;GO:0007274,neuromuscular synaptic transmission;GO:0007269,neurotransmitter secretion;GO:0006836,neurotransmitter transport;GO:0070527,platelet aggregation;GO:0002576,platelet degranulation;GO:0045956,positive regulation of calcium ion-dependent exocytosis;GO:1903296,positive regulation of glutamate secretion, neurotransmission;GO:0043306,positive regulation of mast cell degranulation;GO:0106022,positive regulation of vesicle docking;GO:0099525,presynaptic dense core vesicle exocytosis;GO:0072659,protein localization to plasma membrane;GO:0050821,protein stabilization;GO:2000367,regulation of acrosomal vesicle exocytosis;GO:0035542,regulation of SNARE complex assembly;GO:0031630,regulation of synaptic vesicle fusion to presynaptic active zone membrane;GO:0010807,regulation of synaptic vesicle priming;GO:0032355,response to estradiol;GO:0035493,SNARE complex assembly;GO:0016188,synaptic vesicle maturation;GO:0016082,synaptic vesicle priming;GO:0006904,vesicle docking involved in exocytosis;GO:0016192,vesicle-mediated transport;GO:0015031,protein transport	hsa:6812,path:hsa04721,Synaptic vesicle cycle
MGST2_HUMAN	Q99735	MGST2	Microsomal glutathione S-transferase 2	1.36237125	1.872065513	0.204593351	0.421389534	1.6172183815	0.3129914425	1.6172183815	0.3129914425	5.16697315614308	0.060323	0	0.193536906382238	0.059894	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0005886,plasma membrane	GO:0008047,enzyme activator activity;GO:0043295,glutathione binding;GO:0004602,glutathione peroxidase activity;GO:0004364,glutathione transferase activity;GO:0042802,identical protein binding;GO:0004464,leukotriene-C4 synthase activity	GO:0046222,aflatoxin metabolic process;GO:0006750,glutathione biosynthetic process;GO:1901687,glutathione derivative biosynthetic process;GO:0019370,leukotriene biosynthetic process;GO:0006629,lipid metabolic process;GO:0046466,membrane lipid catabolic process;GO:0050729,positive regulation of inflammatory response;GO:0032496,response to lipopolysaccharide;GO:0010243,response to organonitrogen compound	hsa:4258,path:hsa00480,Glutathione metabolism;hsa:4258,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:4258,path:hsa00982,Drug metabolism - cytochrome P450;hsa:4258,path:hsa00983,Drug metabolism - other enzymes;hsa:4258,path:hsa05200,Pathways in cancer;hsa:4258,path:hsa05204,Chemical carcinogenesis;hsa:4258,path:hsa05225,Hepatocellular carcinoma;hsa:4258,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:4258,path:hsa01524,Platinum drug resistance
DCNL1_HUMAN	Q96GG9	DCUN1D1	DCN1-like protein 1	0.122795449	0.132540677	0.164823593	0.197409053	0.127668063	0.181116323	0.127668063	0.181116323	0.704895400289238	0.409009	0	1.41865019914965	0.409200	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000151,ubiquitin ligase complex	GO:0097602,cullin family protein binding;GO:0031624,ubiquitin conjugating enzyme binding;GO:0032182,ubiquitin-like protein binding	GO:2000436,positive regulation of protein neddylation;GO:0051443,positive regulation of ubiquitin-protein transferase activity;GO:0043687,post-translational protein modification;GO:0045116,protein neddylation;GO:2000434,regulation of protein neddylation;GO:0031396,regulation of protein ubiquitination	
SPS1_HUMAN	P49903	SEPHS1	Selenide, water dikinase 1	0.473216277	0.315114442	0.697578995	0.053463726	0.3941653595	0.3755213605	0.3941653595	0.3755213605	1.04964830489316	0.417345	0	0.952700057093678	0.417114	0	GO:0005737,cytoplasm;GO:0031965,nuclear membrane;GO:0005886,plasma membrane	GO:0005524,ATP binding;GO:0005525,GTP binding;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0004756,selenide, water dikinase activity;GO:0016740,transferase activity	GO:0006464,cellular protein modification process;GO:0016260,selenocysteine biosynthetic process	hsa:22929,path:hsa00450,Selenocompound metabolism
TGFI1_HUMAN	O43294	TGFB1I1	Transforming growth factor beta-1-induced transcript 1 protein	1.010136002	0.511508648	0.635475506	1.452446076	0.760822325	1.043960791	0.760822325	1.043960791	0.728784386884124	0.428905	0	1.3721479466313	0.429075	0	GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0016363,nuclear matrix;GO:0005886,plasma membrane	GO:0050681,androgen receptor binding;GO:0070411,I-SMAD binding;GO:0046872,metal ion binding;GO:0048495,Roundabout binding;GO:0003713,transcription coactivator activity;GO:0003712,transcription coregulator activity	GO:0007155,cell adhesion;GO:0045165,cell fate commitment;GO:0030855,epithelial cell differentiation;GO:0016331,morphogenesis of embryonic epithelium;GO:0008285,negative regulation of cell population proliferation;GO:0045599,negative regulation of fat cell differentiation;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0010718,positive regulation of epithelial to mesenchymal transition;GO:0045893,positive regulation of transcription, DNA-templated;GO:0030511,positive regulation of transforming growth factor beta receptor signaling pathway;GO:0009408,response to heat;GO:0030579,ubiquitin-dependent SMAD protein catabolic process;GO:0016055,Wnt signaling pathway	
LAMP1_HUMAN	P11279	LAMP1	Lysosome-associated membrane glycoprotein 1	3.491605184	7.00770767	7.34857586	8.609310303	5.249656427	7.9789430815	5.249656427	7.9789430815	0.657938823899104	0.368644	0	1.51989814808884	0.368875	0	GO:0097208,alveolar lamellar body;GO:0044754,autolysosome;GO:0000421,autophagosome membrane;GO:0035577,azurophil granule membrane;GO:0101004,cytolytic granule membrane;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0010008,endosome membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0101003,ficolin-1-rich granule membrane;GO:0005887,integral component of plasma membrane;GO:0030285,integral component of synaptic vesicle membrane;GO:0005770,late endosome;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0042470,melanosome;GO:0016020,membrane;GO:0005771,multivesicular body;GO:0043025,neuronal cell body;GO:0048471,perinuclear region of cytoplasm;GO:0061474,phagolysosome membrane;GO:0005886,plasma membrane;GO:0042383,sarcolemma	GO:0019899,enzyme binding;GO:0019904,protein domain specific binding;GO:0001618,virus receptor activity	GO:0048102,autophagic cell death;GO:0072594,establishment of protein localization to organelle;GO:0090160,Golgi to lysosome transport;GO:0140507,granzyme-mediated programmed cell death signaling pathway;GO:0043312,neutrophil degranulation;GO:0043323,positive regulation of natural killer cell degranulation;GO:0045954,positive regulation of natural killer cell mediated cytotoxicity;GO:0050821,protein stabilization;GO:1902513,regulation of organelle transport along microtubule	hsa:3916,path:hsa04145,Phagosome;hsa:3916,path:hsa04142,Lysosome;hsa:3916,path:hsa04140,Autophagy - animal;hsa:3916,path:hsa05152,Tuberculosis
CSDE1_HUMAN	O75534	CSDE1	Cold shock domain-containing protein E1	1.304412118	0.964811699	1.769209234	1.237584963	1.1346119085	1.5033970985	1.1346119085	1.5033970985	0.754698748342702	0.449959	0	1.32503201071417	0.450106	0	GO:0070937,CRD-mediated mRNA stability complex;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0000932,P-body;GO:0005886,plasma membrane	GO:0003723,RNA binding;GO:0035613,RNA stem-loop binding;GO:0003676,nucleic acid binding	GO:0075522,IRES-dependent viral translational initiation;GO:0008584,male gonad development;GO:0070966,nuclear-transcribed mRNA catabolic process, no-go decay;GO:0006446,regulation of translational initiation;GO:0034063,stress granule assembly	
CDK7_HUMAN	P50613	CDK7	Cyclin-dependent kinase 7	0.085041795	0.062003145	0.112706399	0.044874867	0.07352247	0.078790633	0.07352247	0.078790633	0.933137191574537	0.456395	0	1.0716537814902	0.456248	0	GO:0070516,CAK-ERCC2 complex;GO:0019907,cyclin-dependent protein kinase activating kinase holoenzyme complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0001650,fibrillar center;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0000439,transcription factor TFIIH core complex;GO:0005675,transcription factor TFIIH holo complex;GO:0070985,transcription factor TFIIK complex	GO:0005524,ATP binding;GO:0008094,ATPase activity, acting on DNA;GO:0004693,cyclin-dependent protein serine/threonine kinase activity;GO:0008022,protein C-terminus binding;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0106311,protein threonine kinase activity;GO:0008353,RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0006370,7-methylguanosine mRNA capping;GO:0007050,cell cycle arrest;GO:0051301,cell division;GO:0000082,G1/S transition of mitotic cell cycle;GO:0000086,G2/M transition of mitotic cell cycle;GO:0006294,nucleotide-excision repair, preincision complex assembly;GO:0070816,phosphorylation of RNA polymerase II C-terminal domain;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0006468,protein phosphorylation;GO:0050821,protein stabilization;GO:0000079,regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0042795,snRNA transcription by RNA polymerase II;GO:0006363,termination of RNA polymerase I transcription;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter;GO:0006361,transcription initiation from RNA polymerase I promoter;GO:0006367,transcription initiation from RNA polymerase II promoter;GO:0006283,transcription-coupled nucleotide-excision repair	hsa:1022,path:hsa03022,Basal transcription factors;hsa:1022,path:hsa03420,Nucleotide excision repair;hsa:1022,path:hsa04110,Cell cycle
IGHM_HUMAN	P01871	IGHM	Immunoglobulin heavy constant mu	32.48362954	8.600639661	36.52243749	81.82903195	20.5421346005	59.17573472	20.5421346005	59.17573472	0.347137803995144	0.094663	0	2.88070036881949	0.094956	0	GO:0072562,blood microparticle;GO:0009986,cell surface;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0071757,hexameric IgM immunoglobulin complex;GO:0042571,immunoglobulin complex, circulating;GO:0016021,integral component of membrane;GO:0071756,pentameric IgM immunoglobulin complex;GO:0005886,plasma membrane	GO:0003823,antigen binding	GO:0002250,adaptive immune response;GO:0019731,antibacterial humoral response;GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0050829,defense response to Gram-negative bacterium;GO:0045087,innate immune response;GO:0050900,leukocyte migration;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation	
RN213_HUMAN	Q63HN8	RNF213	E3 ubiquitin-protein ligase RNF213	1.14316638	2.061363855	3.109877956	1.595219505	1.6022651175	2.3525487305	1.6022651175	2.3525487305	0.681076271333798	0.388731	0	1.46826433703472	0.388942	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005730,nucleolus	GO:0016887,ATPase activity;GO:0046872,metal ion binding;GO:0004842,ubiquitin-protein transferase activity	GO:0001525,angiogenesis;GO:0033668,negative regulation by symbiont of host apoptotic process;GO:2000051,negative regulation of non-canonical Wnt signaling pathway;GO:0051865,protein autoubiquitination;GO:0051260,protein homooligomerization;GO:0000209,protein polyubiquitination;GO:0016567,protein ubiquitination;GO:0002040,sprouting angiogenesis;GO:0006511,ubiquitin-dependent protein catabolic process	
ODO2_HUMAN	P36957	DLST	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial	5.772936709	9.576931294	6.371298052	6.986520723	7.6749340015	6.6789093875	7.6749340015	6.6789093875	1.14912982887058	0.387818	0	0.870223690027128	0.387526	0	GO:0034451,centriolar satellite;GO:0005829,cytosol;GO:0016020,membrane;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0045252,oxoglutarate dehydrogenase complex	GO:0004149,dihydrolipoyllysine-residue succinyltransferase activity;GO:0016746,transferase activity, transferring acyl groups;GO:0016740,transferase activity	GO:0006103,2-oxoglutarate metabolic process;GO:0006091,generation of precursor metabolites and energy;GO:0106077,histone succinylation;GO:0033512,L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0006554,lysine catabolic process;GO:0006104,succinyl-CoA metabolic process;GO:0006099,tricarboxylic acid cycle	hsa:1743,path:hsa00020,Citrate cycle (TCA cycle);hsa:1743,path:hsa00310,Lysine degradation;hsa:1743,path:hsa00380,Tryptophan metabolism
CO3A1_HUMAN	P02461	COL3A1	Collagen alpha-1(III) chain	1.044387872	0.443754172	0.517710743	5.16834957	0.744071022	2.8430301565	0.744071022	2.8430301565	0.261717597436958	0.040560	-1	3.82091234900961	0.040755	1	GO:0005586,collagen type III trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0005201,extracellular matrix structural constituent;GO:0030020,extracellular matrix structural constituent conferring tensile strength;GO:0005178,integrin binding;GO:0046872,metal ion binding;GO:0048407,platelet-derived growth factor binding;GO:0002020,protease binding	GO:0007160,cell-matrix adhesion;GO:0021987,cerebral cortex development;GO:0030199,collagen fibril organization;GO:0030198,extracellular matrix organization;GO:0007507,heart development;GO:0007229,integrin-mediated signaling pathway;GO:0050777,negative regulation of immune response;GO:2001223,negative regulation of neuron migration;GO:0018149,peptide cross-linking;GO:0030168,platelet activation;GO:0035025,positive regulation of Rho protein signal transduction;GO:0050776,regulation of immune response;GO:0034097,response to cytokine;GO:0009612,response to mechanical stimulus;GO:0009314,response to radiation;GO:0001501,skeletal system development;GO:0043588,skin development;GO:0097435,supramolecular fiber organization;GO:0007179,transforming growth factor beta receptor signaling pathway;GO:0042060,wound healing	hsa:1281,path:hsa04611,Platelet activation;hsa:1281,path:hsa04926,Relaxin signaling pathway;hsa:1281,path:hsa04974,Protein digestion and absorption;hsa:1281,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:1281,path:hsa05146,Amoebiasis
MGLL_HUMAN	Q99685	MGLL	Monoglyceride lipase	0.321175524	0.661687399	1.001094395	1.180802466	0.4914314615	1.0909484305	0.4914314615	1.0909484305	0.450462595445294	0.180256	0	2.21994014622118	0.180591	0	GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0019898,extrinsic component of membrane;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0047372,acylglycerol lipase activity;GO:0016298,lipase activity;GO:0004622,lysophospholipase activity;GO:0042803,protein homodimerization activity	GO:0036155,acylglycerol acyl-chain remodeling;GO:0046464,acylglycerol catabolic process;GO:0019369,arachidonic acid metabolic process;GO:0006633,fatty acid biosynthetic process;GO:0006954,inflammatory response;GO:0006629,lipid metabolic process;GO:0052651,monoacylglycerol catabolic process;GO:2000124,regulation of endocannabinoid signaling pathway;GO:0050727,regulation of inflammatory response;GO:0051930,regulation of sensory perception of pain;GO:0009966,regulation of signal transduction;GO:0019433,triglyceride catabolic process	hsa:11343,path:hsa00561,Glycerolipid metabolism;hsa:11343,path:hsa04923,Regulation of lipolysis in adipocytes;hsa:11343,path:hsa04723,Retrograde endocannabinoid signaling;hsa:11343,path:hsa04714,Thermogenesis
GNS_HUMAN	P15586	GNS	N-acetylglucosamine-6-sulfatase	0.987761867	1.697864428	1.738917744	1.766743897	1.3428131475	1.7528308205	1.3428131475	1.7528308205	0.766082574424929	0.459027	0	1.3053423134584	0.459164	0	GO:0035578,azurophil granule lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0043202,lysosomal lumen;GO:0005764,lysosome	GO:0005539,glycosaminoglycan binding;GO:0046872,metal ion binding;GO:0008449,N-acetylglucosamine-6-sulfatase activity;GO:0008484,sulfuric ester hydrolase activity	GO:0006027,glycosaminoglycan catabolic process;GO:0042340,keratan sulfate catabolic process;GO:0043312,neutrophil degranulation;GO:0030203,glycosaminoglycan metabolic process	hsa:2799,path:hsa00531,Glycosaminoglycan degradation;hsa:2799,path:hsa04142,Lysosome
MYLK_HUMAN	Q15746	MYLK	Myosin light chain kinase, smooth muscle	4.413440601	8.20635507	4.824496478	10.49635665	6.3098978355	7.660426564	6.3098978355	7.660426564	0.823700584136296	0.498254	0	1.21403337481977	0.498200	0	GO:0015629,actin cytoskeleton;GO:0032154,cleavage furrow;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030027,lamellipodium;GO:0005886,plasma membrane;GO:0001725,stress fiber	GO:0003779,actin binding;GO:0005524,ATP binding;GO:0005516,calmodulin binding;GO:0046872,metal ion binding;GO:0004687,myosin light chain kinase activity;GO:0004672,protein kinase activity	GO:0060414,aorta smooth muscle tissue morphogenesis;GO:0032060,bleb assembly;GO:0071476,cellular hypotonic response;GO:0006936,muscle contraction;GO:0051928,positive regulation of calcium ion transport;GO:0030335,positive regulation of cell migration;GO:0090303,positive regulation of wound healing;GO:0006468,protein phosphorylation;GO:0006939,smooth muscle contraction;GO:0014820,tonic smooth muscle contraction	hsa:4638,path:hsa04371,Apelin signaling pathway;hsa:4638,path:hsa04020,Calcium signaling pathway;hsa:4638,path:hsa04022,cGMP-PKG signaling pathway;hsa:4638,path:hsa04510,Focal adhesion;hsa:4638,path:hsa04810,Regulation of actin cytoskeleton;hsa:4638,path:hsa04611,Platelet activation;hsa:4638,path:hsa04921,Oxytocin signaling pathway;hsa:4638,path:hsa04270,Vascular smooth muscle contraction;hsa:4638,path:hsa04971,Gastric acid secretion
TRI23_HUMAN	P36406	TRIM23	E3 ubiquitin-protein ligase TRIM23	0.365833697	3.361920472	2.55E-05	2.55E-05	1.8638770845	2.55e-005	1.8638770845	2.55e-005	73093.219	0.000000	1	1.36811596709128e-005	0.000000	-1	GO:0000139,Golgi membrane;GO:0005765,lysosomal membrane;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0008047,enzyme activator activity;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0004842,ubiquitin-protein transferase activity;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0045087,innate immune response;GO:0006886,intracellular protein transport;GO:0016567,protein ubiquitination;GO:0016192,vesicle-mediated transport;GO:0016032,viral process	
K1H1_HUMAN	Q15323	KRT31	Keratin, type I cuticular Ha1	0.031807261	0.217899891	0.044444712	0.402111458	0.124853576	0.223278085	0.124853576	0.223278085	0.559184194006322	0.279615	0	1.78831950315945	0.279917	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005882,intermediate filament	GO:0005200,structural constituent of cytoskeleton	GO:0070268,cornification;GO:0008544,epidermis development;GO:0031424,keratinization	hsa:3881,path:hsa04915,Estrogen signaling pathway;hsa:3881,path:hsa05150,Staphylococcus aureus infection
ALKB5_HUMAN	Q6P6C2	ALKBH5	RNA demethylase ALKBH5	0.068383993	0.02953	0.108554641	2.55E-05	0.0489569965	0.0542900705	0.0489569965	0.0542900705	0.901767045964694	0.467841	0	1.10893384768814	0.467720	0	GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0016706,2-oxoglutarate-dependent dioxygenase activity;GO:0046872,metal ion binding;GO:0035515,oxidative RNA demethylase activity;GO:0003723,RNA binding;GO:1990931,RNA N6-methyladenosine dioxygenase activity	GO:0030154,cell differentiation;GO:0006307,DNA dealkylation involved in DNA repair;GO:0006406,mRNA export from nucleus;GO:0006397,mRNA processing;GO:0035553,oxidative single-stranded RNA demethylation;GO:0043488,regulation of mRNA stability;GO:0001666,response to hypoxia;GO:0007283,spermatogenesis	
MFAP4_HUMAN	P55083	MFAP4	Microfibril-associated glycoprotein 4	0.119698651	2.54649995	1.846540192	14.14178273	1.3330993005	7.994161461	1.3330993005	7.994161461	0.166759116262988	0.007487	-1	5.99667365964536	0.007550	1	GO:0062023,collagen-containing extracellular matrix;GO:0071953,elastic fiber;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0001527,microfibril	GO:0003823,antigen binding;GO:0097367,carbohydrate derivative binding;GO:0005102,signaling receptor binding	GO:0007155,cell adhesion;GO:0071493,cellular response to UV-B;GO:0001867,complement activation, lectin pathway;GO:0048251,elastic fiber assembly;GO:0010712,regulation of collagen metabolic process;GO:0097435,supramolecular fiber organization;GO:0009650,UV protection	
SPTB1_HUMAN	P11277	SPTB	Spectrin beta chain, erythrocytic	3.497709212	4.540470996	5.702470464	59.08471427	4.019090104	32.393592367	4.019090104	32.393592367	0.124070527852117	0.001958	-1	8.05993185740232	0.001980	1	GO:0015629,actin cytoskeleton;GO:0009986,cell surface;GO:0005829,cytosol;GO:0031235,intrinsic component of the cytoplasmic side of the plasma membrane;GO:0032991,protein-containing complex;GO:0008091,spectrin;GO:0014731,spectrin-associated cytoskeleton	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0030506,ankyrin binding;GO:0005200,structural constituent of cytoskeleton	GO:0051693,actin filament capping;GO:0007411,axon guidance;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0000165,MAPK cascade	
ILKAP_HUMAN	Q9H0C8	ILKAP	Integrin-linked kinase-associated serine/threonine phosphatase 2C	0.135908488	0.042364508	0.205909316	0.092755812	0.089136498	0.149332564	0.089136498	0.149332564	0.596899267061403	0.314108	0	1.67532455672647	0.314386	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0046872,metal ion binding;GO:0106306,protein serine phosphatase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0106307,protein threonine phosphatase activity;GO:0016301,kinase activity	GO:0006470,protein dephosphorylation;GO:0007229,integrin-mediated signaling pathway	
TPD54_HUMAN	O43399	TPD52L2	Tumor protein D54	1.62781307	3.395060527	1.069156335	0.183930138	2.5114367985	0.6265432365	2.5114367985	0.6265432365	4.0084014193967	0.090436	0	0.249476011848761	0.089930	0	GO:0005737,cytoplasm;GO:0048471,perinuclear region of cytoplasm	GO:0042803,protein homodimerization activity;GO:0003723,RNA binding	GO:0005975,carbohydrate metabolic process;GO:0042127,regulation of cell population proliferation	
UTRN_HUMAN	P46939	UTRN	Utrophin	9.948203422	3.762269398	7.507804987	15.10450244	6.85523641	11.3061537135	6.85523641	11.3061537135	0.606327897507229	0.322655	0	1.64927261983369	0.322926	0	GO:0030864,cortical actin cytoskeleton;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0016010,dystrophin-associated glycoprotein complex;GO:0070062,extracellular exosome;GO:0030175,filopodium;GO:0031527,filopodium membrane;GO:0030426,growth cone;GO:0016020,membrane;GO:0031594,neuromuscular junction;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0045211,postsynaptic membrane;GO:0032991,protein-containing complex;GO:0042383,sarcolemma;GO:0045202,synapse	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0005178,integrin binding;GO:0019901,protein kinase binding;GO:0017166,vinculin binding;GO:0008270,zinc ion binding	GO:0006936,muscle contraction;GO:0007517,muscle organ development;GO:0007528,neuromuscular junction development;GO:0001954,positive regulation of cell-matrix adhesion;GO:2000649,regulation of sodium ion transmembrane transporter activity;GO:0014894,response to denervation involved in regulation of muscle adaptation	
LAMA5_HUMAN	O15230	LAMA5	Laminin subunit alpha-5	7.840855397	1.524457632	5.272475853	32.33729379	4.6826565145	18.8048848215	4.6826565145	18.8048848215	0.249012772954941	0.034359	-1	4.01585825551587	0.034536	1	GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043259,laminin-10 complex;GO:0043260,laminin-11 complex;GO:0005610,laminin-5 complex;GO:0031594,neuromuscular junction;GO:0005634,nucleus;GO:0043083,synaptic cleft	GO:0005201,extracellular matrix structural constituent;GO:0005178,integrin binding	GO:0009887,animal organ morphogenesis;GO:0007411,axon guidance;GO:0060445,branching involved in salivary gland morphogenesis;GO:0001658,branching involved in ureteric bud morphogenesis;GO:0016477,cell migration;GO:0098609,cell-cell adhesion;GO:0060271,cilium assembly;GO:0019221,cytokine-mediated signaling pathway;GO:0030198,extracellular matrix organization;GO:0001942,hair follicle development;GO:0007229,integrin-mediated signaling pathway;GO:0030324,lung development;GO:0001738,morphogenesis of a polarized epithelium;GO:0016331,morphogenesis of embryonic epithelium;GO:0007517,muscle organ development;GO:0001755,neural crest cell migration;GO:0042475,odontogenesis of dentin-containing tooth;GO:0072659,protein localization to plasma membrane;GO:0030155,regulation of cell adhesion;GO:0030334,regulation of cell migration;GO:0042127,regulation of cell population proliferation;GO:0045995,regulation of embryonic development;GO:0034446,substrate adhesion-dependent cell spreading;GO:0009888,tissue development	hsa:3911,path:hsa04151,PI3K-Akt signaling pathway;hsa:3911,path:hsa04512,ECM-receptor interaction;hsa:3911,path:hsa04510,Focal adhesion;hsa:3911,path:hsa05200,Pathways in cancer;hsa:3911,path:hsa05222,Small cell lung cancer;hsa:3911,path:hsa05165,Human papillomavirus infection;hsa:3911,path:hsa05146,Amoebiasis;hsa:3911,path:hsa05145,Toxoplasmosis
DEGS1_HUMAN	O15121	DEGS1	Sphingolipid delta(4)-desaturase DES1	0.111523841	0.077080101	0.042176232	0.078202375	0.094301971	0.0601893035	0.094301971	0.0601893035	1.56675630911728	0.292430	0	0.638261351928689	0.291968	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0031966,mitochondrial membrane;GO:0005739,mitochondrion;GO:0005886,plasma membrane;GO:0035579,specific granule membrane;GO:0016021,integral component of membrane	GO:0009055,electron transfer activity;GO:0050251,retinol isomerase activity;GO:0042284,sphingolipid delta-4 desaturase activity	GO:0046513,ceramide biosynthetic process;GO:0043217,myelin maintenance;GO:0043312,neutrophil degranulation;GO:0030148,sphingolipid biosynthetic process;GO:0006636,unsaturated fatty acid biosynthetic process	hsa:8560,path:hsa00600,Sphingolipid metabolism;hsa:8560,path:hsa04071,Sphingolipid signaling pathway
UBC12_HUMAN	P61081	UBE2M	NEDD8-conjugating enzyme Ubc12	3.460652339	2.843060127	0.318031952	0.02838772	3.151856233	0.173209836	3.151856233	0.173209836	18.1967508646564	0.004485	1	0.054954865703102	0.004407	-1	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0019788,NEDD8 transferase activity;GO:0004842,ubiquitin-protein transferase activity;GO:0016740,transferase activity	GO:0006464,cellular protein modification process;GO:0043525,positive regulation of neuron apoptotic process;GO:0043687,post-translational protein modification;GO:0045116,protein neddylation	hsa:9040,path:hsa04120,Ubiquitin mediated proteolysis
EMAL4_HUMAN	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	3.223100455	4.125501721	4.561248762	3.945437673	3.674301088	4.2533432175	3.674301088	4.2533432175	0.863861884665789	0.482252	0	1.15759245517225	0.482162	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005874,microtubule;GO:0005815,microtubule organizing center;GO:0030496,midbody;GO:0072686,mitotic spindle;GO:0005856,cytoskeleton	GO:0043014,alpha-tubulin binding;GO:0048487,beta-tubulin binding;GO:0008017,microtubule binding	GO:0008608,attachment of spindle microtubules to kinetochore;GO:0051301,cell division;GO:0000226,microtubule cytoskeleton organization;GO:0007017,microtubule-based process;GO:0000278,mitotic cell cycle;GO:0007080,mitotic metaphase plate congression;GO:0007052,mitotic spindle organization	hsa:27436,path:hsa05200,Pathways in cancer;hsa:27436,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:27436,path:hsa05223,Non-small cell lung cancer
AL3B1_HUMAN	P43353	ALDH3B1	Aldehyde dehydrogenase family 3 member B1	0.02300262	0.035943517	0.097956259	0.141580819	0.0294730685	0.119768539	0.0294730685	0.119768539	0.246083560391431	0.033005	-1	4.0636603209469	0.033178	1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0035579,specific granule membrane;GO:0031982,vesicle	GO:0004028,3-chloroallyl aldehyde dehydrogenase activity;GO:0004030,aldehyde dehydrogenase [NAD(P)+] activity;GO:0018479,benzaldehyde dehydrogenase (NAD+) activity;GO:0018477,benzaldehyde dehydrogenase (NADP+) activity;GO:0016491,oxidoreductase activity;GO:0016620,oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	GO:0006066,alcohol metabolic process;GO:0046185,aldehyde catabolic process;GO:0034599,cellular response to oxidative stress;GO:0006068,ethanol catabolic process;GO:0006629,lipid metabolic process;GO:0043312,neutrophil degranulation;GO:0006979,response to oxidative stress;GO:0030148,sphingolipid biosynthetic process	hsa:221,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:221,path:hsa00340,Histidine metabolism;hsa:221,path:hsa00350,Tyrosine metabolism;hsa:221,path:hsa00360,Phenylalanine metabolism;hsa:221,path:hsa00410,beta-Alanine metabolism;hsa:221,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:221,path:hsa00982,Drug metabolism - cytochrome P450;hsa:221,path:hsa05204,Chemical carcinogenesis
HORN_HUMAN	Q86YZ3	HRNR	Hornerin	4.856532537	2.55E-05	2.363356949	0.071885505	2.4282790185	1.217621227	2.4282790185	1.217621227	1.99428111522238	0.226729	0	0.501433821123303	0.226187	0	GO:0035578,azurophil granule lumen;GO:0062023,collagen-containing extracellular matrix;GO:0001533,cornified envelope;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0036457,keratohyalin granule;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm	GO:0005509,calcium ion binding;GO:0046914,transition metal ion binding	GO:0043163,cell envelope organization;GO:0061436,establishment of skin barrier;GO:0031424,keratinization;GO:0043312,neutrophil degranulation	
RAB34_HUMAN	Q9BZG1	RAB34	Ras-related protein Rab-34	0.301086	0.407288948	0.516617248	0.244349377	0.354187474	0.3804833125	0.354187474	0.3804833125	0.930888326409847	0.457202	0	1.07424271164372	0.457057	0	GO:0005730,nucleolus;GO:0005929,cilium;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0031985,Golgi cisterna;GO:0005795,Golgi stack;GO:0048471,perinuclear region of cytoplasm;GO:0045335,phagocytic vesicle;GO:0030670,phagocytic vesicle membrane;GO:0031982,vesicle	GO:0005525,GTP binding;GO:0030742,GTP-dependent protein binding;GO:0003924,GTPase activity;GO:0031267,small GTPase binding	GO:0019882,antigen processing and presentation;GO:0030030,cell projection organization;GO:0006897,endocytosis;GO:0043001,Golgi to plasma membrane protein transport;GO:0032418,lysosome localization;GO:0090382,phagosome maturation;GO:0090385,phagosome-lysosome fusion;GO:0045880,positive regulation of smoothened signaling pathway;GO:0072659,protein localization to plasma membrane	
DPP3_HUMAN	Q9NY33	DPP3	Dipeptidyl peptidase 3	3.608863666	3.768804717	6.546957301	10.05283995	3.6888341915	8.2998986255	3.6888341915	8.2998986255	0.444443282736815	0.174907	0	2.25000588116025	0.175243	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0008239,dipeptidyl-peptidase activity;GO:0070006,metalloaminopeptidase activity;GO:0008270,zinc ion binding;GO:0016787,hydrolase activity;GO:0046872,metal ion binding	GO:0006508,proteolysis	
MVP_HUMAN	Q14764	MVP	Major vault protein	34.17841581	28.41514649	33.16024899	56.02395219	31.29678115	44.59210059	31.29678115	44.59210059	0.701845859152427	0.406436	0	1.42481427646753	0.406630	0	GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0005643,nuclear pore;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0034774,secretory granule lumen	GO:0042802,identical protein binding;GO:0019901,protein kinase binding;GO:0019903,protein phosphatase binding	GO:0038127,ERBB signaling pathway;GO:0051028,mRNA transport;GO:0042059,negative regulation of epidermal growth factor receptor signaling pathway;GO:0031953,negative regulation of protein autophosphorylation;GO:0061099,negative regulation of protein tyrosine kinase activity;GO:0043312,neutrophil degranulation;GO:0015031,protein transport	
MFS10_HUMAN	Q14728	MFSD10	Major facilitator superfamily domain-containing protein 10	0.438874586	0.555519524	0.342648762	0.36937271	0.497197055	0.356010736	0.497197055	0.356010736	1.39657882395996	0.326576	0	0.716035488182849	0.326169	0	GO:0031526,brush border membrane;GO:0030659,cytoplasmic vesicle membrane;GO:0016021,integral component of membrane;GO:0005637,nuclear inner membrane	GO:0008514,organic anion transmembrane transporter activity;GO:0008493,tetracycline transmembrane transporter activity;GO:0022857,transmembrane transporter activity	GO:0006915,apoptotic process;GO:0043252,sodium-independent organic anion transport	
CRKL_HUMAN	P46109	CRKL	Crk-like protein	0.63582082	1.321466679	0.79816883	0.731987068	0.9786437495	0.765077949	0.9786437495	0.765077949	1.27914253806314	0.353699	0	0.781773704058179	0.353341	0	GO:0005829,cytosol;GO:0098890,extrinsic component of postsynaptic membrane;GO:0031594,neuromuscular junction;GO:0005654,nucleoplasm;GO:0032991,protein-containing complex	GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0001784,phosphotyrosine residue binding;GO:0003723,RNA binding	GO:0095500,acetylcholine receptor signaling pathway;GO:0090630,activation of GTPase activity;GO:0000187,activation of MAPK activity;GO:0000186,activation of MAPKK activity;GO:0009952,anterior/posterior pattern specification;GO:0001783,B cell apoptotic process;GO:0001568,blood vessel development;GO:0060326,cell chemotaxis;GO:0035690,cellular response to drug;GO:0098761,cellular response to interleukin-7;GO:0071560,cellular response to transforming growth factor beta stimulus;GO:0098749,cerebellar neuron development;GO:0021987,cerebral cortex development;GO:1904888,cranial skeletal system development;GO:0019221,cytokine-mediated signaling pathway;GO:0016358,dendrite development;GO:0086100,endothelin receptor signaling pathway;GO:0030010,establishment of cell polarity;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0035685,helper T cell diapedesis;GO:0021766,hippocampus development;GO:0035556,intracellular signal transduction;GO:0007254,JNK cascade;GO:0006629,lipid metabolic process;GO:0008584,male gonad development;GO:0010629,negative regulation of gene expression;GO:0001933,negative regulation of protein phosphorylation;GO:0001764,neuron migration;GO:0003151,outflow tract morphogenesis;GO:0060017,parathyroid gland development;GO:0060465,pharynx development;GO:0008284,positive regulation of cell population proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:1903977,positive regulation of glial cell migration;GO:0001934,positive regulation of protein phosphorylation;GO:0046579,positive regulation of Ras protein signal transduction;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0007265,Ras protein signal transduction;GO:0038026,reelin-mediated signaling pathway;GO:0033628,regulation of cell adhesion mediated by integrin;GO:0001558,regulation of cell growth;GO:0050773,regulation of dendrite development;GO:1904393,regulation of skeletal muscle acetylcholine-gated channel clustering;GO:2000404,regulation of T cell migration;GO:0048384,retinoic acid receptor signaling pathway;GO:0007338,single fertilization;GO:0007283,spermatogenesis;GO:0007416,synapse assembly;GO:0050852,T cell receptor signaling pathway;GO:0048538,thymus development;GO:0001655,urogenital system development	hsa:1399,path:hsa04015,Rap1 signaling pathway;hsa:1399,path:hsa04010,MAPK signaling pathway;hsa:1399,path:hsa04012,ErbB signaling pathway;hsa:1399,path:hsa04510,Focal adhesion;hsa:1399,path:hsa04810,Regulation of actin cytoskeleton;hsa:1399,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:1399,path:hsa04062,Chemokine signaling pathway;hsa:1399,path:hsa04910,Insulin signaling pathway;hsa:1399,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:1399,path:hsa04722,Neurotrophin signaling pathway;hsa:1399,path:hsa05200,Pathways in cancer;hsa:1399,path:hsa05206,MicroRNAs in cancer;hsa:1399,path:hsa05220,Chronic myeloid leukemia;hsa:1399,path:hsa05211,Renal cell carcinoma;hsa:1399,path:hsa05131,Shigellosis;hsa:1399,path:hsa05135,Yersinia infection;hsa:1399,path:hsa05100,Bacterial invasion of epithelial cells;hsa:1399,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:1399,path:hsa05163,Human cytomegalovirus infection
SGPL1_HUMAN	O95470	SGPL1	Sphingosine-1-phosphate lyase 1	2.421601122	0.662640898	1.063064021	1.813869127	1.54212101	1.438466574	1.54212101	1.438466574	1.07205898133021	0.410408	0	0.932784499187907	0.410162	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016021,integral component of membrane	GO:0016831,carboxy-lyase activity;GO:0030170,pyridoxal phosphate binding;GO:0008117,sphinganine-1-phosphate aldolase activity;GO:0003824,catalytic activity	GO:0001667,ameboidal-type cell migration;GO:0008209,androgen metabolic process;GO:0097190,apoptotic signaling pathway;GO:0006672,ceramide metabolic process;GO:0008210,estrogen metabolic process;GO:0060325,face morphogenesis;GO:0006631,fatty acid metabolic process;GO:0010761,fibroblast migration;GO:0030097,hemopoiesis;GO:0001822,kidney development;GO:0033327,Leydig cell differentiation;GO:0001553,luteinization;GO:0048008,platelet-derived growth factor receptor signaling pathway;GO:0009791,post-embryonic development;GO:0040014,regulation of multicellular organism growth;GO:0060021,roof of mouth development;GO:0048705,skeletal system morphogenesis;GO:0007283,spermatogenesis;GO:0030148,sphingolipid biosynthetic process;GO:0030149,sphingolipid catabolic process;GO:0001570,vasculogenesis	hsa:8879,path:hsa00600,Sphingolipid metabolism;hsa:8879,path:hsa04071,Sphingolipid signaling pathway
NCK1_HUMAN	P16333	NCK1	Cytoplasmic protein NCK1	0.035761725	0.030283411	0.043604182	2.55E-05	0.033022568	0.021814841	0.033022568	0.021814841	1.51376615580191	0.302473	0	0.660604014805875	0.302026	0	GO:0005911,cell-cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0000164,protein phosphatase type 1 complex;GO:0005840,ribosome;GO:0012506,vesicle membrane	GO:0045296,cadherin binding;GO:0008093,cytoskeletal anchor activity;GO:0046875,ephrin receptor binding;GO:0071074,eukaryotic initiation factor eIF2 binding;GO:0019904,protein domain specific binding;GO:0004860,protein kinase inhibitor activity;GO:0030674,protein-macromolecule adaptor activity;GO:0030971,receptor tyrosine kinase binding;GO:0035591,signaling adaptor activity;GO:0005102,signaling receptor binding;GO:0030159,signaling receptor complex adaptor activity;GO:0003779,actin binding	GO:0007015,actin filament organization;GO:0048013,ephrin receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0030032,lamellipodium assembly;GO:0060548,negative regulation of cell death;GO:1903912,negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;GO:0046627,negative regulation of insulin receptor signaling pathway;GO:0033137,negative regulation of peptidyl-serine phosphorylation;GO:1903898,negative regulation of PERK-mediated unfolded protein response;GO:1990441,negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:0070262,peptidyl-serine dephosphorylation;GO:0030838,positive regulation of actin filament polymerization;GO:1903676,positive regulation of cap-dependent translational initiation;GO:1903679,positive regulation of cap-independent translational initiation;GO:1902237,positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0010976,positive regulation of neuron projection development;GO:0042102,positive regulation of T cell proliferation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0036493,positive regulation of translation in response to endoplasmic reticulum stress;GO:0030334,regulation of cell migration;GO:0051707,response to other organism;GO:0007172,signal complex assembly;GO:0006930,substrate-dependent cell migration, cell extension;GO:0042110,T cell activation;GO:0050852,T cell receptor signaling pathway;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:0051017,actin filament bundle assembly;GO:0051016,barbed-end actin filament capping	hsa:4690,path:hsa04012,ErbB signaling pathway;hsa:4690,path:hsa04660,T cell receptor signaling pathway;hsa:4690,path:hsa04360,Axon guidance;hsa:4690,path:hsa05130,Pathogenic Escherichia coli infection
TRI16_HUMAN	O95361	TRIM16	Tripartite motif-containing protein 16	0.29000834	0.154478636	0.237190397	0.035899838	0.222243488	0.1365451175	0.222243488	0.1365451175	1.62761944234293	0.281489	0	0.614394233679414	0.281011	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005886,plasma membrane;GO:0016605,PML body	GO:0003677,DNA binding;GO:0019966,interleukin-1 binding;GO:0032089,NACHT domain binding;GO:0016740,transferase activity;GO:0008270,zinc ion binding	GO:0043966,histone H3 acetylation;GO:0043967,histone H4 acetylation;GO:0032731,positive regulation of interleukin-1 beta production;GO:0045618,positive regulation of keratinocyte differentiation;GO:0048386,positive regulation of retinoic acid receptor signaling pathway;GO:0045893,positive regulation of transcription, DNA-templated;GO:0060416,response to growth hormone;GO:0046683,response to organophosphorus;GO:0032526,response to retinoic acid;GO:0006355,regulation of transcription, DNA-templated	
GCDH_HUMAN	Q92947	GCDH	Glutaryl-CoA dehydrogenase, mitochondrial	1.855759584	1.12314011	1.660705414	1.022030435	1.489449847	1.3413679245	1.489449847	1.3413679245	1.11039620062124	0.398933	0	0.9005794503264	0.398663	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0000062,fatty-acyl-CoA binding;GO:0050660,flavin adenine dinucleotide binding;GO:0004361,glutaryl-CoA dehydrogenase activity;GO:0016627,oxidoreductase activity, acting on the CH-CH group of donors;GO:0003995,acyl-CoA dehydrogenase activity	GO:0033539,fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0046949,fatty-acyl-CoA biosynthetic process;GO:0006554,lysine catabolic process;GO:0006568,tryptophan metabolic process	hsa:2639,path:hsa00071,Fatty acid degradation;hsa:2639,path:hsa00310,Lysine degradation;hsa:2639,path:hsa00380,Tryptophan metabolism
CATB_HUMAN	P07858	CTSB	Cathepsin B	13.76982413	28.95421611	9.627791059	3.631005476	21.36202012	6.6293982675	21.36202012	6.6293982675	3.22231660522272	0.124233	0	0.310335737456463	0.123680	0	GO:0016324,apical plasma membrane;GO:0062023,collagen-containing extracellular matrix;GO:0036021,endolysosome lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0005622,intracellular anatomical structure;GO:0005764,lysosome;GO:0042470,melanosome;GO:0048471,perinuclear region of cytoplasm	GO:0005518,collagen binding;GO:0004197,cysteine-type endopeptidase activity;GO:0008234,cysteine-type peptidase activity;GO:0008233,peptidase activity;GO:0043394,proteoglycan binding	GO:0097067,cellular response to thyroid hormone stimulus;GO:0030574,collagen catabolic process;GO:0030855,epithelial cell differentiation;GO:0043312,neutrophil degranulation;GO:0006508,proteolysis;GO:0051603,proteolysis involved in cellular protein catabolic process;GO:0042981,regulation of apoptotic process;GO:0050790,regulation of catalytic activity;GO:0002224,toll-like receptor signaling pathway	hsa:1508,path:hsa04142,Lysosome;hsa:1508,path:hsa04140,Autophagy - animal;hsa:1508,path:hsa04210,Apoptosis;hsa:1508,path:hsa04621,NOD-like receptor signaling pathway;hsa:1508,path:hsa04612,Antigen processing and presentation;hsa:1508,path:hsa04924,Renin secretion
EPN1_HUMAN	Q9Y6I3	EPN1	Epsin-1	0.243071116	0.414766629	0.260988791	0.150451247	0.3289188725	0.205720019	0.3289188725	0.205720019	1.59886662512898	0.286581	0	0.625443038389352	0.286110	0	GO:0030125,clathrin vesicle coat;GO:0005905,clathrin-coated pit;GO:0005829,cytosol;GO:0005768,endosome;GO:0043231,intracellular membrane-bounded organelle;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0030276,clathrin binding;GO:0005543,phospholipid binding	GO:0006897,endocytosis;GO:0061024,membrane organization;GO:0042059,negative regulation of epidermal growth factor receptor signaling pathway;GO:1903671,negative regulation of sprouting angiogenesis	hsa:29924,path:hsa04144,Endocytosis
PEF1_HUMAN	Q9UBV8	PEF1	Peflin	0.503033746	0.607387091	0.643847341	0.53170022	0.5552104185	0.5877737805	0.5552104185	0.5877737805	0.944598818320376	0.452317	0	1.05865048802214	0.452161	0	GO:0030127,COPII vesicle coat;GO:0031463,Cul3-RING ubiquitin ligase complex;GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome	GO:0005509,calcium ion binding;GO:0048306,calcium-dependent protein binding;GO:0042802,identical protein binding;GO:0046983,protein dimerization activity;GO:0046982,protein heterodimerization activity;GO:0003723,RNA binding;GO:1990756,ubiquitin ligase-substrate adaptor activity	GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0014032,neural crest cell development;GO:0014029,neural crest formation;GO:1902527,positive regulation of protein monoubiquitination;GO:0051592,response to calcium ion	
1433B_HUMAN	P31946	YWHAB	14-3-3 protein beta/alpha	8.081895766	18.75483375	8.36621333	9.891897981	13.418364758	9.1290556555	13.418364758	9.1290556555	1.46985244305262	0.311187	0	0.680340400648095	0.310754	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0042470,melanosome;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0017053,transcription repressor complex;GO:0005774,vacuolar membrane	GO:0045296,cadherin binding;GO:0019899,enzyme binding;GO:0042826,histone deacetylase binding;GO:0042802,identical protein binding;GO:0051219,phosphoprotein binding;GO:0050815,phosphoserine residue binding;GO:0008022,protein C-terminus binding;GO:0019904,protein domain specific binding;GO:0004860,protein kinase inhibitor activity;GO:0044877,protein-containing complex binding	GO:0000186,activation of MAPKK activity;GO:0002250,adaptive immune response;GO:0051220,cytoplasmic sequestering of protein;GO:0035329,hippo signaling;GO:0000165,MAPK cascade;GO:0045744,negative regulation of G protein-coupled receptor signaling pathway;GO:0035308,negative regulation of protein dephosphorylation;GO:0045892,negative regulation of transcription, DNA-templated;GO:0043085,positive regulation of catalytic activity;GO:1900740,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0006605,protein targeting;GO:0043488,regulation of mRNA stability;GO:0016032,viral process	hsa:7529,path:hsa04390,Hippo signaling pathway;hsa:7529,path:hsa04151,PI3K-Akt signaling pathway;hsa:7529,path:hsa04110,Cell cycle;hsa:7529,path:hsa04114,Oocyte meiosis;hsa:7529,path:hsa05203,Viral carcinogenesis;hsa:7529,path:hsa05161,Hepatitis B;hsa:7529,path:hsa05160,Hepatitis C
MYL3_HUMAN	P08590	MYL3	Myosin light chain 3	0.23643456	0.424641619	0.188946074	0.240043462	0.3305380895	0.214494768	0.3305380895	0.214494768	1.54100770187551	0.297248	0	0.648926023395558	0.296793	0	GO:0031672,A band;GO:0005829,cytosol;GO:0031674,I band;GO:0005859,muscle myosin complex;GO:0030017,sarcomere	GO:0003785,actin monomer binding;GO:0005509,calcium ion binding;GO:0003774,motor activity;GO:0032038,myosin II heavy chain binding;GO:0008307,structural constituent of muscle	GO:0060048,cardiac muscle contraction;GO:0030049,muscle filament sliding;GO:0032781,positive regulation of ATPase activity;GO:0006942,regulation of striated muscle contraction;GO:0002026,regulation of the force of heart contraction;GO:0007519,skeletal muscle tissue development;GO:0055010,ventricular cardiac muscle tissue morphogenesis	hsa:4634,path:hsa04371,Apelin signaling pathway;hsa:4634,path:hsa04260,Cardiac muscle contraction;hsa:4634,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:4634,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:4634,path:hsa05414,Dilated cardiomyopathy (DCM)
API5_HUMAN	Q9BZZ5	API5	Apoptosis inhibitor 5	1.758358953	1.868173915	2.89018835	2.015089751	1.813266434	2.4526390505	1.813266434	2.4526390505	0.739312388274314	0.437526	0	1.35260820170237	0.437687	0	GO:0005737,cytoplasm;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005634,nucleus;GO:0005681,spliceosomal complex	GO:0017134,fibroblast growth factor binding;GO:0003723,RNA binding	GO:0006915,apoptotic process;GO:0043066,negative regulation of apoptotic process;GO:2000270,negative regulation of fibroblast apoptotic process	
ODB2_HUMAN	P11182	DBT	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial	0.402367932	0.267174991	0.870241012	0.470560614	0.3347714615	0.670400813	0.3347714615	0.670400813	0.499360166348724	0.224553	0	2.00256261389832	0.224882	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0015630,microtubule cytoskeleton;GO:0005947,mitochondrial alpha-ketoglutarate dehydrogenase complex;GO:0005759,mitochondrial matrix;GO:0042645,mitochondrial nucleoid;GO:0005739,mitochondrion	GO:0016407,acetyltransferase activity;GO:0043754,dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity;GO:0031405,lipoic acid binding;GO:0031625,ubiquitin protein ligase binding;GO:0016746,transferase activity, transferring acyl groups	GO:0009083,branched-chain amino acid catabolic process	hsa:1629,path:hsa00640,Propanoate metabolism;hsa:1629,path:hsa00280,Valine, leucine and isoleucine degradation
UCHL1_HUMAN	P09936	UCHL1	Ubiquitin carboxyl-terminal hydrolase isozyme L1	0.454669545	1.174204612	0.29149719	0.714347716	0.8144370785	0.502922453	0.8144370785	0.502922453	1.61940886441195	0.282930	0	0.617509278833749	0.282454	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0005654,nucleoplasm;GO:1904115,axon cytoplasm;GO:0044306,neuron projection terminus;GO:0043025,neuronal cell body	GO:0031694,alpha-2A adrenergic receptor binding;GO:0004197,cysteine-type endopeptidase activity;GO:0016874,ligase activity;GO:0008242,omega peptidase activity;GO:0004843,thiol-dependent deubiquitinase;GO:0043130,ubiquitin binding;GO:0031625,ubiquitin protein ligase binding	GO:0043407,negative regulation of MAP kinase activity;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0016241,regulation of macroautophagy;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0007628,adult walking behavior;GO:0007412,axon target recognition;GO:0019896,axonal transport of mitochondrion;GO:0008283,cell population proliferation;GO:0035690,cellular response to drug;GO:0042755,eating behavior;GO:0048747,muscle fiber development;GO:0050905,neuromuscular process;GO:0002931,response to ischemia;GO:0019233,sensory perception of pain	hsa:7345,path:hsa05012,Parkinson disease
NAV1_HUMAN	Q8NEY1	NAV1	Neuron navigator 1	0.08469155	0.128573281	0.122745977	0.454576057	0.1066324155	0.288661017	0.1066324155	0.288661017	0.369403588361916	0.111694	0	2.70706628604882	0.112004	0	GO:0043194,axon initial segment;GO:0005737,cytoplasm;GO:0005874,microtubule;GO:0015630,microtubule cytoskeleton		GO:0001578,microtubule bundle formation;GO:0007399,nervous system development;GO:0001764,neuron migration;GO:0022008,neurogenesis	
VAT1_HUMAN	Q99536	VAT1	Synaptic vesicle membrane protein VAT-1 homolog	4.845473277	9.661967469	10.13464288	19.96752528	7.253720373	15.05108408	7.253720373	15.05108408	0.481940060559412	0.208634	0	2.07494682811645	0.208967	0	GO:0035578,azurophil granule lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0016021,integral component of membrane;GO:0005741,mitochondrial outer membrane	GO:0016491,oxidoreductase activity;GO:0008270,zinc ion binding	GO:0010637,negative regulation of mitochondrial fusion;GO:0043312,neutrophil degranulation	
PSMG1_HUMAN	O95456	PSMG1	Proteasome assembly chaperone 1	0.075857374	0.106951346	0.115003998	0.081929959	0.09140436	0.0984669785	0.09140436	0.0984669785	0.928274243735427	0.458142	0	1.07726785133663	0.457999	0	GO:0101031,chaperone complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0060090,molecular adaptor activity;GO:0070628,proteasome binding	GO:0021930,cerebellar granule cell precursor proliferation;GO:0051131,chaperone-mediated protein complex assembly;GO:0080129,proteasome core complex assembly;GO:0043248,proteasome assembly	
IGKC_HUMAN	P01834	IGKC	Immunoglobulin kappa constant	44.29070503	58.03669811	60.39761911	91.53735737	51.16370157	75.96748824	51.16370157	75.96748824	0.673494711426568	0.382190	0	1.48479265394949	0.382408	0	GO:0072562,blood microparticle;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0042571,immunoglobulin complex, circulating;GO:0005886,plasma membrane	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0045087,innate immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0001895,retina homeostasis	
DECR_HUMAN	Q16698	DECR1	2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial	4.165454074	11.78221219	5.343948904	4.993588244	7.973833132	5.168768574	7.973833132	5.168768574	1.54269494132704	0.296928	0	0.648216295530073	0.296473	0	GO:1902494,catalytic complex;GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0008670,2,4-dienoyl-CoA reductase (NADPH) activity;GO:0042802,identical protein binding;GO:0070402,NADPH binding;GO:0016491,oxidoreductase activity	GO:0006635,fatty acid beta-oxidation;GO:0120162,positive regulation of cold-induced thermogenesis	
SYK_HUMAN	Q15046	KARS1	Lysine--tRNA ligase	5.590890782	3.578410846	7.292523743	8.211463208	4.584650814	7.7519934755	4.584650814	7.7519934755	0.59141572145148	0.309121	0	1.69085799333463	0.309403	0	GO:0017101,aminoacyl-tRNA synthetase multienzyme complex;GO:0005829,cytosol;GO:0005615,extracellular space;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0016597,amino acid binding;GO:0003877,ATP adenylyltransferase activity;GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0004824,lysine-tRNA ligase activity;GO:0042803,protein homodimerization activity;GO:0000049,tRNA binding;GO:0003676,nucleic acid binding;GO:0000166,nucleotide binding;GO:0004812,aminoacyl-tRNA ligase activity	GO:0002276,basophil activation involved in immune response;GO:0015966,diadenosine tetraphosphate biosynthetic process;GO:0070371,ERK1 and ERK2 cascade;GO:0006430,lysyl-tRNA aminoacylation;GO:0002863,positive regulation of inflammatory response to antigenic stimulus;GO:0043032,positive regulation of macrophage activation;GO:0045893,positive regulation of transcription, DNA-templated;GO:0010165,response to X-ray;GO:0006418,tRNA aminoacylation for protein translation;GO:0008033,tRNA processing;GO:0016032,viral process	hsa:3735,path:hsa00970,Aminoacyl-tRNA biosynthesis
KAD2_HUMAN	P54819	AK2	Adenylate kinase 2, mitochondrial	5.596232543	3.322418301	4.29264933	1.784772653	4.459325422	3.0387109915	4.459325422	3.0387109915	1.46750560829042	0.311663	0	0.68142840092104	0.311231	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005758,mitochondrial intermembrane space;GO:0005739,mitochondrion;GO:0097226,sperm mitochondrial sheath	GO:0004017,adenylate kinase activity;GO:0005524,ATP binding;GO:0004550,nucleoside diphosphate kinase activity	GO:0006172,ADP biosynthetic process;GO:0046033,AMP metabolic process;GO:0046034,ATP metabolic process;GO:0015949,nucleobase-containing small molecule interconversion	hsa:204,path:hsa00230,Purine metabolism;hsa:204,path:hsa00730,Thiamine metabolism
PTPRC_HUMAN	P08575	PTPRC	Receptor-type tyrosine-protein phosphatase C	2.438408626	1.75389608	5.942627794	2.587251984	2.096152353	4.264939889	2.096152353	4.264939889	0.491484618202083	0.217343	0	2.03465167161921	0.217674	0	GO:0032059,bleb;GO:0009986,cell surface;GO:0009898,cytoplasmic side of plasma membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0098857,membrane microdomain;GO:0045121,membrane raft;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane	GO:0030506,ankyrin binding;GO:0043395,heparan sulfate proteoglycan binding;GO:0008201,heparin binding;GO:0019901,protein kinase binding;GO:0004725,protein tyrosine phosphatase activity;GO:0005102,signaling receptor binding;GO:0030507,spectrin binding;GO:0005001,transmembrane receptor protein tyrosine phosphatase activity	GO:0000187,activation of MAPK activity;GO:0030183,B cell differentiation;GO:0042100,B cell proliferation;GO:0050853,B cell receptor signaling pathway;GO:0048539,bone marrow development;GO:0035584,calcium-mediated signaling using intracellular calcium source;GO:0044770,cell cycle phase transition;GO:0007166,cell surface receptor signaling pathway;GO:0031668,cellular response to extracellular stimulus;GO:0051607,defense response to virus;GO:0016311,dephosphorylation;GO:1904155,DN2 thymocyte differentiation;GO:0002244,hematopoietic progenitor cell differentiation;GO:0034113,heterotypic cell-cell adhesion;GO:0007159,leukocyte cell-cell adhesion;GO:0001779,natural killer cell differentiation;GO:0006933,negative regulation of cell adhesion involved in substrate-bound cell migration;GO:0001960,negative regulation of cytokine-mediated signaling pathway;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:0032703,negative regulation of interleukin-2 production;GO:1903979,negative regulation of microglial cell activation;GO:0031953,negative regulation of protein autophosphorylation;GO:0006469,negative regulation of protein kinase activity;GO:0061099,negative regulation of protein tyrosine kinase activity;GO:0001915,negative regulation of T cell mediated cytotoxicity;GO:0045060,negative thymic T cell selection;GO:0043312,neutrophil degranulation;GO:0044855,plasma membrane raft distribution;GO:0046641,positive regulation of alpha-beta T cell proliferation;GO:0050857,positive regulation of antigen receptor-mediated signaling pathway;GO:0030890,positive regulation of B cell proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:2001238,positive regulation of extrinsic apoptotic signaling pathway;GO:1905451,positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0045588,positive regulation of gamma-delta T cell differentiation;GO:2000473,positive regulation of hematopoietic stem cell migration;GO:0002925,positive regulation of humoral immune response mediated by circulating immunoglobulin;GO:0002639,positive regulation of immunoglobulin production;GO:0032743,positive regulation of interleukin-2 production;GO:0048304,positive regulation of isotype switching to IgG isotypes;GO:0043410,positive regulation of MAPK cascade;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0045860,positive regulation of protein kinase activity;GO:1903615,positive regulation of protein tyrosine phosphatase activity;GO:2000648,positive regulation of stem cell proliferation;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:0042102,positive regulation of T cell proliferation;GO:0032760,positive regulation of tumor necrosis factor production;GO:0045059,positive thymic T cell selection;GO:0006470,protein dephosphorylation;GO:0051726,regulation of cell cycle;GO:0010468,regulation of gene expression;GO:0032677,regulation of interleukin-8 production;GO:0050764,regulation of phagocytosis;GO:0061097,regulation of protein tyrosine kinase activity;GO:0046425,regulation of receptor signaling pathway via JAK-STAT;GO:0051209,release of sequestered calcium ion into cytosol;GO:0010332,response to gamma radiation;GO:0048864,stem cell development;GO:0042110,T cell activation;GO:0030217,T cell differentiation;GO:0042098,T cell proliferation;GO:0050852,T cell receptor signaling pathway;GO:0016032,viral process	hsa:5788,path:hsa04514,Cell adhesion molecules (CAMs);hsa:5788,path:hsa04660,T cell receptor signaling pathway;hsa:5788,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:5788,path:hsa05340,Primary immunodeficiency;hsa:5788,path:hsa05132,Salmonella infection
ATG7_HUMAN	O95352	ATG7	Ubiquitin-like modifier-activating enzyme ATG7	0.360758364	0.668436901	0.796527047	0.89709061	0.5145976325	0.8468088285	0.5145976325	0.8468088285	0.607690443439915	0.323887	0	1.64557466847654	0.324157	0	GO:0030424,axon;GO:0005930,axoneme;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0000407,phagophore assembly site;GO:0034774,secretory granule lumen	GO:0019778,Atg12 activating enzyme activity;GO:0019779,Atg8 activating enzyme activity;GO:0042803,protein homodimerization activity;GO:0008134,transcription factor binding	GO:0007568,aging;GO:0000045,autophagosome assembly;GO:0006914,autophagy;GO:0000422,autophagy of mitochondrion;GO:0006501,C-terminal protein lipidation;GO:0071455,cellular response to hyperoxia;GO:0071315,cellular response to morphine;GO:0006995,cellular response to nitrogen starvation;GO:0009267,cellular response to starvation;GO:0061684,chaperone-mediated autophagy;GO:0051607,defense response to virus;GO:0044805,late nucleophagy;GO:0016236,macroautophagy;GO:0090298,negative regulation of mitochondrial DNA replication;GO:1903204,negative regulation of oxidative stress-induced neuron death;GO:0043312,neutrophil degranulation;GO:0034727,piecemeal microautophagy of the nucleus;GO:0075044,positive regulation by symbiont of host autophagy;GO:0043065,positive regulation of apoptotic process;GO:0010508,positive regulation of autophagy;GO:0045732,positive regulation of protein catabolic process;GO:0031401,positive regulation of protein modification process;GO:0006497,protein lipidation;GO:0032446,protein modification by small protein conjugation;GO:0015031,protein transport;GO:0042752,regulation of circadian rhythm;GO:1902617,response to fluoride;GO:0009749,response to glucose;GO:0048511,rhythmic process;GO:0039521,suppression by virus of host autophagy	hsa:10533,path:hsa04140,Autophagy - animal;hsa:10533,path:hsa04136,Autophagy - other;hsa:10533,path:hsa04216,Ferroptosis
GDIA_HUMAN	P31150	GDI1	Rab GDP dissociation inhibitor alpha	3.633092738	2.794633438	3.113133281	3.384018263	3.213863088	3.248575772	3.213863088	3.248575772	0.989314491507573	0.436916	0	1.01080092183442	0.436727	0	GO:0030424,axon;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0030496,midbody;GO:0043209,myelin sheath;GO:0043025,neuronal cell body;GO:0032991,protein-containing complex	GO:0005092,GDP-dissociation inhibitor activity;GO:0005096,GTPase activator activity;GO:0005093,Rab GDP-dissociation inhibitor activity;GO:0031267,small GTPase binding	GO:0050771,negative regulation of axonogenesis;GO:0090315,negative regulation of protein targeting to membrane;GO:0045773,positive regulation of axon extension;GO:0043547,positive regulation of GTPase activity;GO:0015031,protein transport;GO:0032482,Rab protein signal transduction;GO:0051592,response to calcium ion;GO:0007165,signal transduction;GO:0016192,vesicle-mediated transport;GO:0007264,small GTPase mediated signal transduction	
RB6I2_HUMAN	Q8IUD2	ERC1	ELKS/Rab6-interacting/CAST family member 1	0.218156823	0.22280725	0.102718035	0.357373727	0.2204820365	0.230045881	0.2204820365	0.230045881	0.958426360609343	0.447469	0	1.04337697824194	0.447303	0	GO:0005813,centrosome;GO:0036064,ciliary basal body;GO:0005737,cytoplasm;GO:0048788,cytoskeleton of presynaptic active zone;GO:0000139,Golgi membrane;GO:0008385,IkappaB kinase complex;GO:0042734,presynaptic membrane;GO:0045202,synapse;GO:0016020,membrane	GO:0045296,cadherin binding;GO:0043522,leucine zipper domain binding;GO:0030165,PDZ domain binding;GO:0031267,small GTPase binding;GO:0098882,structural constituent of presynaptic active zone	GO:0007252,I-kappaB phosphorylation;GO:0048790,maintenance of presynaptic active zone structure;GO:0007275,multicellular organism development;GO:0043066,negative regulation of apoptotic process;GO:0007274,neuromuscular synaptic transmission;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0015031,protein transport;GO:0048167,regulation of synaptic plasticity;GO:0006355,regulation of transcription, DNA-templated;GO:0042147,retrograde transport, endosome to Golgi	hsa:23085,path:hsa04064,NF-kappa B signaling pathway
CASP6_HUMAN	P55212	CASP6	Caspase-6	0.092153559	0.086885664	0.087827202	0.024933658	0.0895196115	0.05638043	0.0895196115	0.05638043	1.58777809073113	0.288581	0	0.629810932546328	0.288113	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm	GO:0004197,cysteine-type endopeptidase activity;GO:0097153,cysteine-type endopeptidase activity involved in apoptotic process;GO:0097200,cysteine-type endopeptidase activity involved in execution phase of apoptosis;GO:0008234,cysteine-type peptidase activity;GO:0042802,identical protein binding	GO:0006915,apoptotic process;GO:0072734,cellular response to staurosporine;GO:0030855,epithelial cell differentiation;GO:0097194,execution phase of apoptosis;GO:0006508,proteolysis;GO:0042981,regulation of apoptotic process	hsa:839,path:hsa04210,Apoptosis
PLCG2_HUMAN	P16885	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2	1.00893301	0.730661272	2.196100243	1.399661423	0.869797141	1.797880833	0.869797141	1.797880833	0.483790207356863	0.210320	0	2.06701166082587	0.210652	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005886,plasma membrane	GO:0004435,phosphatidylinositol phospholipase C activity;GO:0140031,phosphorylation-dependent protein binding;GO:0001784,phosphotyrosine residue binding;GO:0019901,protein kinase binding;GO:0097110,scaffold protein binding;GO:0008081,phosphoric diester hydrolase activity	GO:0032237,activation of store-operated calcium channel activity;GO:0030183,B cell differentiation;GO:0050853,B cell receptor signaling pathway;GO:0019722,calcium-mediated signaling;GO:0071277,cellular response to calcium ion;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0002316,follicular B cell differentiation;GO:0043647,inositol phosphate metabolic process;GO:0032959,inositol trisphosphate biosynthetic process;GO:0035556,intracellular signal transduction;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0043069,negative regulation of programmed cell death;GO:0006661,phosphatidylinositol biosynthetic process;GO:0009395,phospholipid catabolic process;GO:0030168,platelet activation;GO:1902808,positive regulation of cell cycle G1/S phase transition;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0010634,positive regulation of epithelial cell migration;GO:0010628,positive regulation of gene expression;GO:0002092,positive regulation of receptor internalization;GO:0032481,positive regulation of type I interferon production;GO:0051209,release of sequestered calcium ion into cytosol;GO:0032496,response to lipopolysaccharide;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0016055,Wnt signaling pathway;GO:0006629,lipid metabolic process;GO:0016042,lipid catabolic process	hsa:5336,path:hsa00562,Inositol phosphate metabolism;hsa:5336,path:hsa04014,Ras signaling pathway;hsa:5336,path:hsa04012,ErbB signaling pathway;hsa:5336,path:hsa04370,VEGF signaling pathway;hsa:5336,path:hsa04064,NF-kappa B signaling pathway;hsa:5336,path:hsa04066,HIF-1 signaling pathway;hsa:5336,path:hsa04020,Calcium signaling pathway;hsa:5336,path:hsa04070,Phosphatidylinositol signaling system;hsa:5336,path:hsa04072,Phospholipase D signaling pathway;hsa:5336,path:hsa04611,Platelet activation;hsa:5336,path:hsa04625,C-type lectin receptor signaling pathway;hsa:5336,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:5336,path:hsa04662,B cell receptor signaling pathway;hsa:5336,path:hsa04664,Fc epsilon RI signaling pathway;hsa:5336,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:5336,path:hsa04670,Leukocyte transendothelial migration;hsa:5336,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:5336,path:hsa04919,Thyroid hormone signaling pathway;hsa:5336,path:hsa04722,Neurotrophin signaling pathway;hsa:5336,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:5336,path:hsa04360,Axon guidance;hsa:5336,path:hsa04380,Osteoclast differentiation;hsa:5336,path:hsa05200,Pathways in cancer;hsa:5336,path:hsa05206,MicroRNAs in cancer;hsa:5336,path:hsa05205,Proteoglycans in cancer;hsa:5336,path:hsa05225,Hepatocellular carcinoma;hsa:5336,path:hsa05214,Glioma;hsa:5336,path:hsa05223,Non-small cell lung cancer;hsa:5336,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:5336,path:hsa05110,Vibrio cholerae infection;hsa:5336,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:5336,path:hsa05131,Shigellosis;hsa:5336,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:5336,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:5336,path:hsa05169,Epstein-Barr virus infection;hsa:5336,path:hsa01521,EGFR tyrosine kinase inhibitor resistance
AIFM1_HUMAN	O95831	AIFM1	Apoptosis-inducing factor 1, mitochondrial	5.626798979	3.410805569	7.955659048	4.995146521	4.518802274	6.4754027845	4.518802274	6.4754027845	0.69784111110687	0.403048	0	1.43299095465136	0.403245	0	GO:0005829,cytosol;GO:0005743,mitochondrial inner membrane;GO:0005758,mitochondrial intermembrane space;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm	GO:0003677,DNA binding;GO:0071949,FAD binding;GO:0016174,NAD(P)H oxidase H2O2-forming activity;GO:0003954,NADH dehydrogenase activity;GO:0016651,oxidoreductase activity, acting on NAD(P)H;GO:0046983,protein dimerization activity;GO:0050660,flavin adenine dinucleotide binding;GO:0016491,oxidoreductase activity	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006915,apoptotic process;GO:0030261,chromosome condensation;GO:0070059,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0033108,mitochondrial respiratory chain complex assembly;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0030182,neuron differentiation;GO:0043065,positive regulation of apoptotic process;GO:0045041,protein import into mitochondrial intermembrane space	hsa:9131,path:hsa04210,Apoptosis;hsa:9131,path:hsa04217,Necroptosis
BGH3_HUMAN	Q15582	TGFBI	Transforming growth factor-beta-induced protein ig-h3	26.04574219	12.87412627	15.89585341	30.02560899	19.45993423	22.9607312	19.45993423	22.9607312	0.847531120001962	0.488665	0	1.17989767738285	0.488590	0	GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane;GO:0005802,trans-Golgi network	GO:0050839,cell adhesion molecule binding;GO:0005518,collagen binding;GO:0050840,extracellular matrix binding;GO:0005201,extracellular matrix structural constituent;GO:0042802,identical protein binding;GO:0005178,integrin binding	GO:1990000,amyloid fibril formation;GO:0001525,angiogenesis;GO:0007155,cell adhesion;GO:0008283,cell population proliferation;GO:0002062,chondrocyte differentiation;GO:0030198,extracellular matrix organization;GO:0007162,negative regulation of cell adhesion;GO:0050896,response to stimulus;GO:0007601,visual perception	
AGM1_HUMAN	O95394	PGM3	Phosphoacetylglucosamine mutase	0.944296376	0.481348313	0.96747823	0.440368994	0.7128223445	0.703923612	0.7128223445	0.703923612	1.01264161671565	0.429190	0	0.987516198715345	0.428984	0	GO:0005829,cytosol	GO:0000287,magnesium ion binding;GO:0004610,phosphoacetylglucosamine mutase activity;GO:0004614,phosphoglucomutase activity;GO:0046872,metal ion binding;GO:0016868,intramolecular transferase activity, phosphotransferases	GO:0005975,carbohydrate metabolic process;GO:0006041,glucosamine metabolic process;GO:0019255,glucose 1-phosphate metabolic process;GO:0030097,hemopoiesis;GO:0006487,protein N-linked glycosylation;GO:0006493,protein O-linked glycosylation;GO:0007283,spermatogenesis;GO:0006048,UDP-N-acetylglucosamine biosynthetic process;GO:0071704,organic substance metabolic process	hsa:5238,path:hsa00520,Amino sugar and nucleotide sugar metabolism
NXP20_HUMAN	Q8IWE2	FAM114A1	Protein NOXP20	0.43063484	0.424906825	0.546931847	0.045786076	0.4277708325	0.2963589615	0.4277708325	0.2963589615	1.44342128321299	0.316612	0	0.692798430804653	0.316188	0	GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0005654,nucleoplasm			
PAPOA_HUMAN	P51003	PAPOLA	Poly(A) polymerase alpha	0.107547972	0.05738322	0.144863445	0.08819257	0.082465596	0.1165280075	0.082465596	0.1165280075	0.707689059216086	0.411359	0	1.41304996449671	0.411547	0	GO:0005737,cytoplasm;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0000287,magnesium ion binding;GO:0030145,manganese ion binding;GO:0004652,polynucleotide adenylyltransferase activity;GO:0003723,RNA binding;GO:0046872,metal ion binding	GO:0031124,mRNA 3'-end processing;GO:0006378,mRNA polyadenylation;GO:0000398,mRNA splicing, via spliceosome;GO:0031440,regulation of mRNA 3'-end processing;GO:0043631,RNA polyadenylation;GO:0006369,termination of RNA polymerase II transcription;GO:0006397,mRNA processing;GO:0031123,RNA 3'-end processing	hsa:10914,path:hsa03015,mRNA surveillance pathway
GTPB1_HUMAN	O00178	GTPBP1	GTP-binding protein 1	1.111439818	0.16409095	1.382420427	1.630784622	0.637765384	1.5066025245	0.637765384	1.5066025245	0.423313630256698	0.156394	0	2.36231467291426	0.156727	0	GO:0000177,cytoplasmic exosome (RNase complex);GO:0005829,cytosol;GO:0016020,membrane	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0003723,RNA binding;GO:0003746,translation elongation factor activity	GO:0046039,GTP metabolic process;GO:0006955,immune response;GO:0061014,positive regulation of mRNA catabolic process;GO:0007165,signal transduction;GO:0006414,translational elongation	
RL35_HUMAN	P42766	RPL35	60S ribosomal protein L35	0.501977686	0.036075749	0.284382605	2.55E-05	0.2690267175	0.1422040525	0.2690267175	0.1422040525	1.89183580053037	0.240339	0	0.528587100275645	0.239810	0	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005840,ribosome	GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000463,maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:11224,path:hsa03010,Ribosome
KCC1A_HUMAN	Q14012	CAMK1	Calcium/calmodulin-dependent protein kinase type 1	0.429726583	0.502913376	0.324808544	5.016714015	0.4663199795	2.6707612795	0.4663199795	2.6707612795	0.174601894628074	0.009069	-1	5.72731471287946	0.009141	1	GO:0005829,cytosol;GO:0098978,glutamatergic synapse;GO:0005634,nucleus;GO:0014069,postsynaptic density	GO:0005524,ATP binding;GO:0005516,calmodulin binding;GO:0004683,calmodulin-dependent protein kinase activity;GO:0106310,protein serine kinase activity;GO:0106311,protein threonine kinase activity;GO:0004672,protein kinase activity	GO:0007049,cell cycle;GO:0030154,cell differentiation;GO:0007268,chemical synaptic transmission;GO:0032091,negative regulation of protein binding;GO:0007399,nervous system development;GO:0006913,nucleocytoplasmic transport;GO:0018105,peptidyl-serine phosphorylation;GO:0060999,positive regulation of dendritic spine development;GO:0051149,positive regulation of muscle cell differentiation;GO:0010976,positive regulation of neuron projection development;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:1901985,positive regulation of protein acetylation;GO:0046827,positive regulation of protein export from nucleus;GO:0071902,positive regulation of protein serine/threonine kinase activity;GO:0051835,positive regulation of synapse structural plasticity;GO:0060143,positive regulation of syncytium formation by plasma membrane fusion;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0006468,protein phosphorylation;GO:0051147,regulation of muscle cell differentiation;GO:0043393,regulation of protein binding;GO:0032880,regulation of protein localization;GO:0007165,signal transduction	hsa:8536,path:hsa04020,Calcium signaling pathway;hsa:8536,path:hsa04921,Oxytocin signaling pathway;hsa:8536,path:hsa04925,Aldosterone synthesis and secretion;hsa:8536,path:hsa05214,Glioma
ELMO1_HUMAN	Q92556	ELMO1	Engulfment and cell motility protein 1	0.430639037	0.451828696	1.052335552	1.01229053	0.4412338665	1.032313041	0.4412338665	1.032313041	0.427422544301656	0.159959	0	2.33960518304866	0.160293	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0032045,guanyl-nucleotide exchange factor complex;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0017124,SH3 domain binding	GO:0030036,actin cytoskeleton organization;GO:0007015,actin filament organization;GO:0006915,apoptotic process;GO:0016477,cell migration;GO:0048870,cell motility;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006911,phagocytosis, engulfment;GO:0016601,Rac protein signal transduction;GO:0050790,regulation of catalytic activity;GO:0050690,regulation of defense response to virus by virus;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:0006909,phagocytosis	hsa:9844,path:hsa04062,Chemokine signaling pathway;hsa:9844,path:hsa05131,Shigellosis;hsa:9844,path:hsa05100,Bacterial invasion of epithelial cells
CISY_HUMAN	O75390	CS	Citrate synthase, mitochondrial	9.489280651	17.64384251	13.71199291	8.313795326	13.5665615805	11.012894118	13.5665615805	11.012894118	1.23187977975073	0.365566	0	0.811767525076469	0.365230	0	GO:0070062,extracellular exosome;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0016021,integral component of membrane	GO:0004108,citrate (Si)-synthase activity;GO:0003723,RNA binding;GO:0046912,transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer;GO:0016740,transferase activity	GO:0005975,carbohydrate metabolic process;GO:0006101,citrate metabolic process;GO:0006099,tricarboxylic acid cycle	hsa:1431,path:hsa00020,Citrate cycle (TCA cycle);hsa:1431,path:hsa00630,Glyoxylate and dicarboxylate metabolism
P4HA2_HUMAN	O15460	P4HA2	Prolyl 4-hydroxylase subunit alpha-2	0.213823006	0.186609096	0.390911863	0.091919967	0.200216051	0.241415915	0.200216051	0.241415915	0.829340729255567	0.495959	0	1.20577702833625	0.495900	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0043231,intracellular membrane-bounded organelle;GO:0005654,nucleoplasm	GO:0009055,electron transfer activity;GO:0005506,iron ion binding;GO:0031418,L-ascorbic acid binding;GO:0016702,oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0004656,procollagen-proline 4-dioxygenase activity	GO:0030199,collagen fibril organization;GO:0018401,peptidyl-proline hydroxylation to 4-hydroxy-L-proline	hsa:8974,path:hsa00330,Arginine and proline metabolism
NPT2B_HUMAN	O95436	SLC34A2	Sodium-dependent phosphate transport protein 2B	0.15249436	2.156103763	1.630412796	0.723805778	1.1542990615	1.177109287	1.1542990615	1.177109287	0.980621828617006	0.439848	0	1.01976110547154	0.439665	0	GO:0016324,apical plasma membrane;GO:0005903,brush border;GO:0031526,brush border membrane;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane;GO:0031982,vesicle	GO:0042301,phosphate ion binding;GO:0031402,sodium ion binding;GO:0005436,sodium	GO:0030643,cellular phosphate ion homeostasis;GO:0044267,cellular protein metabolic process;GO:0001701,in utero embryonic development;GO:0006817,phosphate ion transport;GO:0043627,response to estrogen;GO:0044341,sodium-dependent phosphate transport	hsa:10568,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:10568,path:hsa04978,Mineral absorption
LC7L2_HUMAN	Q9Y383	LUC7L2	Putative RNA-binding protein Luc7-like 2	0.852658393	0.637589349	0.758384527	0.598494242	0.745123871	0.6784393845	0.745123871	0.6784393845	1.09829100141223	0.402504	0	0.910505502379751	0.402242	0	GO:0016607,nuclear speck;GO:0005685,U1 snRNP;GO:0071004,U2-type prespliceosome	GO:0019899,enzyme binding;GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0006376,mRNA splice site selection	
AP3D1_HUMAN	O14617	AP3D1	AP-3 complex subunit delta-1	1.0967199	1.075056822	1.757616415	1.025501468	1.085888361	1.3915589415	1.085888361	1.3915589415	0.780339465771742	0.470224	0	1.28149355999958	0.470348	0	GO:0030123,AP-3 adaptor complex;GO:1904115,axon cytoplasm;GO:0010008,endosome membrane;GO:0098978,glutamatergic synapse;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0098794,postsynapse;GO:0098830,presynaptic endosome;GO:0043195,terminal bouton		GO:0008089,anterograde axonal transport;GO:0048490,anterograde synaptic vesicle transport;GO:0048007,antigen processing and presentation, exogenous lipid antigen via MHC class Ib;GO:0035646,endosome to melanosome transport;GO:0006896,Golgi to vacuole transport;GO:0006886,intracellular protein transport;GO:0032438,melanosome organization;GO:0098943,neurotransmitter receptor transport, postsynaptic endosome to lysosome;GO:0051138,positive regulation of NK T cell differentiation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0072657,protein localization to membrane;GO:0006623,protein targeting to vacuole;GO:0061088,regulation of sequestering of zinc ion;GO:0016182,synaptic vesicle budding from endosome;GO:0048499,synaptic vesicle membrane organization;GO:0016192,vesicle-mediated transport	hsa:8943,path:hsa04142,Lysosome
HXK2_HUMAN	P52789	HK2	Hexokinase-2	0.550964063	0.389572903	1.016690968	0.544740206	0.470268483	0.780715587	0.470268483	0.780715587	0.602355698836585	0.319059	0	1.66014864959598	0.319333	0	GO:0005813,centrosome;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0005886,plasma membrane;GO:0016529,sarcoplasmic reticulum	GO:0005524,ATP binding;GO:0008865,fructokinase activity;GO:0004340,glucokinase activity;GO:0005536,glucose binding;GO:0004396,hexokinase activity;GO:0019158,mannokinase activity	GO:0008637,apoptotic mitochondrial changes;GO:0061621,canonical glycolysis;GO:0001678,cellular glucose homeostasis;GO:1990830,cellular response to leukemia inhibitory factor;GO:0072655,establishment of protein localization to mitochondrion;GO:0006002,fructose 6-phosphate metabolic process;GO:0051156,glucose 6-phosphate metabolic process;GO:0006096,glycolytic process;GO:0007595,lactation;GO:0072656,maintenance of protein location in mitochondrion;GO:0035795,negative regulation of mitochondrial membrane permeability;GO:2000378,negative regulation of reactive oxygen species metabolic process;GO:0045766,positive regulation of angiogenesis;GO:1904925,positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization;GO:0046324,regulation of glucose import;GO:0001666,response to hypoxia;GO:0002931,response to ischemia;GO:0019318,hexose metabolic process	hsa:3099,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:3099,path:hsa00051,Fructose and mannose metabolism;hsa:3099,path:hsa00052,Galactose metabolism;hsa:3099,path:hsa00500,Starch and sucrose metabolism;hsa:3099,path:hsa00520,Amino sugar and nucleotide sugar metabolism;hsa:3099,path:hsa00524,Neomycin, kanamycin and gentamicin biosynthesis;hsa:3099,path:hsa04066,HIF-1 signaling pathway;hsa:3099,path:hsa04910,Insulin signaling pathway;hsa:3099,path:hsa04973,Carbohydrate digestion and absorption;hsa:3099,path:hsa05230,Central carbon metabolism in cancer;hsa:3099,path:hsa04930,Type II diabetes mellitus;hsa:3099,path:hsa05131,Shigellosis
TFCP2_HUMAN	Q12800	TFCP2	Alpha-globin transcription factor CP2	0.052085017	0.031328474	0.138133138	0.052718832	0.0417067455	0.095425985	0.0417067455	0.095425985	0.43705858000837	0.168388	0	2.28802280916405	0.168723	0	GO:0000785,chromatin;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0000987,cis-regulatory region sequence-specific DNA binding;GO:0003677,DNA binding;GO:0001228,DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700,DNA-binding transcription factor activity;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0008022,protein C-terminus binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:1990837,sequence-specific double-stranded DNA binding;GO:0008134,transcription factor binding	GO:0042789,mRNA transcription by RNA polymerase II;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0006357,regulation of transcription by RNA polymerase II	
KV37_HUMAN	A0A075B6H7	IGKV3-7	Probable non-functional immunoglobulin kappa variable 3-7	3.947359039	7.896219673	3.303265064	3.77080086	5.921789356	3.537032962	5.921789356	3.537032962	1.67422509759467	0.273514	0	0.597291249209372	0.273025	0	GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0072562,blood microparticle;GO:0005576,extracellular region;GO:0070062,extracellular exosome;GO:0071748,monomeric IgA immunoglobulin complex;GO:0071756,pentameric IgM immunoglobulin complex;GO:0071751,secretory IgA immunoglobulin complex	GO:0003823,antigen binding	GO:0002250,adaptive immune response;GO:0006955,immune response;GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0019731,antibacterial humoral response;GO:0003094,glomerular filtration	
PSA1_HUMAN	P25786	PSMA1	Proteasome subunit alpha type-1	6.857079325	6.827193684	7.447183653	4.708963349	6.8421365045	6.078073501	6.8421365045	6.078073501	1.12570808881701	0.394483	0	0.888329763225641	0.394204	0	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005844,polysome;GO:0000502,proteasome complex;GO:0005839,proteasome core complex;GO:0019773,proteasome core complex, alpha-subunit complex	GO:0004175,endopeptidase activity;GO:0001530,lipopolysaccharide binding;GO:0003723,RNA binding	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0051603,proteolysis involved in cellular protein catabolic process	hsa:5682,path:hsa03050,Proteasome
TBB1_HUMAN	Q9H4B7	TUBB1	Tubulin beta-1 chain	2.55E-05	0.035743143	0.083157127	2.55E-05	0.0178843215	0.0415913135	0.0178843215	0.0415913135	0.430001363145215	0.162206	0	2.32557402303464	0.162540	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005874,microtubule	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0005200,structural constituent of cytoskeleton	GO:0000226,microtubule cytoskeleton organization;GO:0000278,mitotic cell cycle;GO:0051225,spindle assembly	hsa:81027,path:hsa04145,Phagosome;hsa:81027,path:hsa04540,Gap junction;hsa:81027,path:hsa05130,Pathogenic Escherichia coli infection
ARP5L_HUMAN	Q9BPX5	ARPC5L	Actin-related protein 2/3 complex subunit 5-like protein	0.715020442	3.778696491	0.129703986	0.005623785	2.2468584665	0.0676638855	2.2468584665	0.0676638855	33.2061697299367	0.000904	1	0.030114885520761	0.000882	-1	GO:0005885,Arp2/3 protein complex;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse	GO:0051015,actin filament binding	GO:0034314,Arp2/3 complex-mediated actin nucleation;GO:0016477,cell migration	hsa:81873,path:hsa04144,Endocytosis;hsa:81873,path:hsa04810,Regulation of actin cytoskeleton;hsa:81873,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:81873,path:hsa05130,Pathogenic Escherichia coli infection;hsa:81873,path:hsa05132,Salmonella infection;hsa:81873,path:hsa05131,Shigellosis;hsa:81873,path:hsa05100,Bacterial invasion of epithelial cells
SAE2_HUMAN	Q9UBT2	UBA2	SUMO-activating enzyme subunit 2	2.140409959	0.995708969	2.642752375	2.569783513	1.568059464	2.606267944	1.568059464	2.606267944	0.601649369018215	0.318418	0	1.66209764606223	0.318693	0	GO:0005737,cytoplasm;GO:0005654,nucleoplasm;GO:0031510,SUMO activating enzyme complex	GO:0005524,ATP binding;GO:0000287,magnesium ion binding;GO:0046982,protein heterodimerization activity;GO:0044388,small protein activating enzyme binding;GO:0019948,SUMO activating enzyme activity;GO:0032183,SUMO binding;GO:0008134,transcription factor binding;GO:0016740,transferase activity;GO:0044390,ubiquitin-like protein conjugating enzyme binding;GO:0008641,ubiquitin-like modifier activating enzyme activity	GO:0033235,positive regulation of protein sumoylation;GO:0032446,protein modification by small protein conjugation;GO:0016925,protein sumoylation	hsa:10054,path:hsa04120,Ubiquitin mediated proteolysis
PGBM_HUMAN	P98160	HSPG2	Basement membrane-specific heparan sulfate proteoglycan core protein	15.89324168	16.19310763	22.35690794	106.2224974	16.043174655	64.28970267	16.043174655	64.28970267	0.249545012478124	0.034608	-1	4.00729307337956	0.034785	1	GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0005796,Golgi lumen;GO:0043202,lysosomal lumen;GO:0005886,plasma membrane;GO:0098797,plasma membrane protein complex	GO:0001540,amyloid-beta binding;GO:0005509,calcium ion binding;GO:0030021,extracellular matrix structural constituent conferring compression resistance;GO:0005178,integrin binding;GO:0050750,low-density lipoprotein particle receptor binding;GO:0008022,protein C-terminus binding	GO:1990000,amyloid fibril formation;GO:0001525,angiogenesis;GO:0009887,animal organ morphogenesis;GO:0007420,brain development;GO:0030154,cell differentiation;GO:0072359,circulatory system development;GO:0030198,extracellular matrix organization;GO:0006024,glycosaminoglycan biosynthetic process;GO:0006027,glycosaminoglycan catabolic process;GO:0006954,inflammatory response;GO:0006629,lipid metabolic process;GO:1905907,negative regulation of amyloid fibril formation;GO:0016525,negative regulation of angiogenesis;GO:0060548,negative regulation of cell death;GO:0006898,receptor-mediated endocytosis;GO:0001523,retinoid metabolic process;GO:0009888,tissue development	hsa:3339,path:hsa04512,ECM-receptor interaction;hsa:3339,path:hsa05205,Proteoglycans in cancer;hsa:3339,path:hsa05161,Hepatitis B
IBP2_HUMAN	P18065	IGFBP2	Insulin-like growth factor-binding protein 2	0.080539511	0.067442209	0.008887783	0.601210136	0.07399086	0.3050489595	0.07399086	0.3050489595	0.242554048115021	0.031412	-1	4.12279245706835	0.031580	1	GO:0016324,apical plasma membrane;GO:0031410,cytoplasmic vesicle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0031994,insulin-like growth factor I binding;GO:0031995,insulin-like growth factor II binding;GO:0005102,signaling receptor binding;GO:0005520,insulin-like growth factor binding	GO:0007568,aging;GO:0044267,cellular protein metabolic process;GO:0032870,cellular response to hormone stimulus;GO:0007565,female pregnancy;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0042104,positive regulation of activated T cell proliferation;GO:0040008,regulation of growth;GO:0043567,regulation of insulin-like growth factor receptor signaling pathway;GO:0042493,response to drug;GO:0032355,response to estradiol;GO:0043627,response to estrogen;GO:0051384,response to glucocorticoid;GO:0010226,response to lithium ion;GO:0009612,response to mechanical stimulus;GO:0007584,response to nutrient;GO:0032526,response to retinoic acid;GO:0007165,signal transduction;GO:0032868,response to insulin	
DCAF7_HUMAN	P61962	DCAF7	DDB1- and CUL4-associated factor 7	0.125332638	0.054611214	0.148838126	0.103858737	0.089971926	0.1263484315	0.089971926	0.1263484315	0.712093731056725	0.415052	0	1.40430951205824	0.415236	0	GO:0080008,Cul4-RING E3 ubiquitin ligase complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016604,nuclear body;GO:0016363,nuclear matrix;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0030674,protein-macromolecule adaptor activity	GO:0007275,multicellular organism development;GO:0043687,post-translational protein modification;GO:0016567,protein ubiquitination	
RALA_HUMAN	P11233	RALA	Ras-related protein Ral-A	1.416644225	7.459037692	0.275233208	1.484633389	4.4378409585	0.8799332985	4.4378409585	0.8799332985	5.04338336333569	0.062802	0	0.198279592876041	0.062366	0	GO:0009986,cell surface;GO:0032154,cleavage furrow;GO:0030659,cytoplasmic vesicle membrane;GO:0070062,extracellular exosome;GO:0090543,Flemming body;GO:0005925,focal adhesion;GO:0005886,plasma membrane	GO:0051117,ATPase binding;GO:0031755,Edg-2 lysophosphatidic acid receptor binding;GO:0003925,G protein activity;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0017022,myosin binding;GO:0031625,ubiquitin protein ligase binding	GO:0031532,actin cytoskeleton reorganization;GO:0007049,cell cycle;GO:0051301,cell division;GO:0006935,chemotaxis;GO:0006887,exocytosis;GO:0035722,interleukin-12-mediated signaling pathway;GO:0051665,membrane raft localization;GO:0001843,neural tube closure;GO:0051491,positive regulation of filopodium assembly;GO:0007265,Ras protein signal transduction;GO:0017157,regulation of exocytosis;GO:0007165,signal transduction	hsa:5898,path:hsa04014,Ras signaling pathway;hsa:5898,path:hsa04015,Rap1 signaling pathway;hsa:5898,path:hsa04072,Phospholipase D signaling pathway;hsa:5898,path:hsa05200,Pathways in cancer;hsa:5898,path:hsa05210,Colorectal cancer;hsa:5898,path:hsa05212,Pancreatic cancer;hsa:5898,path:hsa05132,Salmonella infection
SETD3_HUMAN	Q86TU7	SETD3	Actin-histidine N-methyltransferase	0.030718461	0.028893879	0.096154433	0.025454197	0.02980617	0.060804315	0.02980617	0.060804315	0.49019826964583	0.216167	0	2.03999088108268	0.216498	0	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005654,nucleoplasm	GO:0003779,actin binding;GO:0046975,histone methyltransferase activity (H3-K36 specific);GO:0042800,histone methyltransferase activity (H3-K4 specific);GO:0018064,protein-histidine N-methyltransferase activity;GO:0001102,RNA polymerase II activating transcription factor binding;GO:0003713,transcription coactivator activity	GO:0030047,actin modification;GO:0010452,histone H3-K36 methylation;GO:0018021,peptidyl-histidine methylation;GO:0018027,peptidyl-lysine dimethylation;GO:0018026,peptidyl-lysine monomethylation;GO:0018023,peptidyl-lysine trimethylation;GO:0051149,positive regulation of muscle cell differentiation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0070472,regulation of uterine smooth muscle contraction	
PRELP_HUMAN	P51888	PRELP	Prolargin	7.111044316	9.948727233	10.52373628	98.99614777	8.5298857745	54.759942025	8.5298857745	54.759942025	0.155768714484865	0.005587	-1	6.41977436423642	0.005637	1	GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1903561,extracellular vesicle;GO:0005796,Golgi lumen;GO:0043202,lysosomal lumen	GO:0005201,extracellular matrix structural constituent;GO:0030021,extracellular matrix structural constituent conferring compression resistance;GO:0008201,heparin binding	GO:0007569,cell aging;GO:0018146,keratan sulfate biosynthetic process;GO:0042340,keratan sulfate catabolic process;GO:0001501,skeletal system development	
ARPC4_HUMAN	P59998	ARPC4	Actin-related protein 2/3 complex subunit 4	15.58284817	66.55018009	2.540252009	0.645286521	41.06651413	1.592769265	41.06651413	1.592769265	25.7830905156247	0.001825	1	0.0387851099306344	0.001787	-1	GO:0005885,Arp2/3 protein complex;GO:0042995,cell projection;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus;GO:0035861,site of double-strand break;GO:0005737,cytoplasm	GO:0003779,actin binding;GO:0019899,enzyme binding;GO:0005200,structural constituent of cytoskeleton;GO:0070735,protein-glycine ligase activity	GO:0030041,actin filament polymerization;GO:0045010,actin nucleation;GO:0034314,Arp2/3 complex-mediated actin nucleation;GO:0048013,ephrin receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0061024,membrane organization;GO:0018094,protein polyglycylation	hsa:10093,path:hsa04144,Endocytosis;hsa:10093,path:hsa04810,Regulation of actin cytoskeleton;hsa:10093,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:10093,path:hsa05130,Pathogenic Escherichia coli infection;hsa:10093,path:hsa05132,Salmonella infection;hsa:10093,path:hsa05131,Shigellosis;hsa:10093,path:hsa05100,Bacterial invasion of epithelial cells
IF4G1_HUMAN	Q04637	EIF4G1	Eukaryotic translation initiation factor 4 gamma 1	3.439825152	4.779034028	4.816016066	5.209906578	4.10942959	5.012961322	4.10942959	5.012961322	0.819760881051538	0.499866	0	1.21986791894395	0.499816	0	GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0016281,eukaryotic translation initiation factor 4F complex;GO:0016020,membrane;GO:0005634,nucleus;GO:0005844,polysome	GO:0005524,ATP binding;GO:0008190,eukaryotic initiation factor 4E binding;GO:0042802,identical protein binding;GO:0060090,molecular adaptor activity;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0008135,translation factor activity, RNA binding;GO:0003743,translation initiation factor activity;GO:0031369,translation initiation factor binding	GO:0001662,behavioral fear response;GO:0002191,cap-dependent translational initiation;GO:0034645,cellular macromolecule biosynthetic process;GO:0031669,cellular response to nutrient levels;GO:0032502,developmental process;GO:0097009,energy homeostasis;GO:0010507,negative regulation of autophagy;GO:1901215,negative regulation of neuron death;GO:0010801,negative regulation of peptidyl-threonine phosphorylation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0010942,positive regulation of cell death;GO:0030307,positive regulation of cell growth;GO:0032270,positive regulation of cellular protein metabolic process;GO:1905537,positive regulation of eukaryotic translation initiation factor 4F complex assembly;GO:1900087,positive regulation of G1/S transition of mitotic cell cycle;GO:1905618,positive regulation of miRNA mediated inhibition of translation;GO:1905612,positive regulation of mRNA cap binding;GO:0045666,positive regulation of neuron differentiation;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0036493,positive regulation of translation in response to endoplasmic reticulum stress;GO:0080135,regulation of cellular response to stress;GO:0060964,regulation of gene silencing by miRNA;GO:0043488,regulation of mRNA stability;GO:1905696,regulation of polysome binding;GO:1905606,regulation of presynapse assembly;GO:0006446,regulation of translational initiation;GO:0006412,translation;GO:0006413,translational initiation;GO:0016032,viral process	hsa:1981,path:hsa03013,RNA transport;hsa:1981,path:hsa05416,Viral myocarditis
UBE2K_HUMAN	P61086	UBE2K	Ubiquitin-conjugating enzyme E2 K	1.520683152	26.19758522	0.307732968	0.004912751	13.859134186	0.1563228595	13.859134186	0.1563228595	88.657117905395	0.000039	1	0.0112794101999468	0.000038	-1	GO:0005829,cytosol;GO:0032433,filopodium tip;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0061631,ubiquitin conjugating enzyme activity;GO:0031625,ubiquitin protein ligase binding;GO:0004842,ubiquitin-protein transferase activity;GO:0034450,ubiquitin-ubiquitin ligase activity	GO:0035458,cellular response to interferon-beta;GO:0010994,free ubiquitin chain polymerization;GO:0070059,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0010800,positive regulation of peptidyl-threonine phosphorylation;GO:1903265,positive regulation of tumor necrosis factor-mediated signaling pathway;GO:0060340,positive regulation of type I interferon-mediated signaling pathway;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936,protein K48-linked ubiquitination;GO:0000209,protein polyubiquitination;GO:0016567,protein ubiquitination;GO:0032434,regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:3093,path:hsa04120,Ubiquitin mediated proteolysis
ADPPT_HUMAN	Q9NRN7	AASDHPPT	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.135863971	0.081813901	0.225823021	0.035555084	0.108838936	0.1306890525	0.108838936	0.1306890525	0.832808363959942	0.494556	0	1.20075643242231	0.494494	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0008897,holo-[acyl-carrier-protein] synthase activity;GO:0000287,magnesium ion binding	GO:0019878,lysine biosynthetic process via aminoadipic acid;GO:0015939,pantothenate metabolic process	hsa:60496,path:hsa00770,Pantothenate and CoA biosynthesis
SAM9L_HUMAN	Q8IVG5	SAMD9L	Sterile alpha motif domain-containing protein 9-like	0.013022068	0.025984124	0.025840576	0.020938902	0.019503096	0.023389739	0.019503096	0.023389739	0.833831279605129	0.494144	0	1.19928338557119	0.494081	0	GO:0005737,cytoplasm;GO:0005769,early endosome			
FAK1_HUMAN	Q05397	PTK2	Focal adhesion kinase 1	0.070758725	0.055382048	0.094135476	0.168614722	0.0630703865	0.131375099	0.0630703865	0.131375099	0.480078698170953	0.206941	0	2.08299181740388	0.207274	0	GO:0005938,cell cortex;GO:0036064,ciliary basal body;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0005925,focal adhesion;GO:0043231,intracellular membrane-bounded organelle;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0001725,stress fiber;GO:0042995,cell projection	GO:0003779,actin binding;GO:0005524,ATP binding;GO:0005178,integrin binding;GO:0008432,JUN kinase binding;GO:0004715,non-membrane spanning protein tyrosine kinase activity;GO:0019901,protein kinase binding;GO:0019903,protein phosphatase binding;GO:0004713,protein tyrosine kinase activity;GO:0042169,SH2 domain binding;GO:0005102,signaling receptor binding;GO:0004714,transmembrane receptor protein tyrosine kinase activity;GO:0004672,protein kinase activity	GO:0001525,angiogenesis;GO:0007411,axon guidance;GO:0030154,cell differentiation;GO:0048870,cell motility;GO:0035995,detection of muscle stretch;GO:0048013,ephrin receptor signaling pathway;GO:0007173,epidermal growth factor receptor signaling pathway;GO:0030010,establishment of cell polarity;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0060396,growth hormone receptor signaling pathway;GO:0003007,heart morphogenesis;GO:0045087,innate immune response;GO:0007229,integrin-mediated signaling pathway;GO:0000165,MAPK cascade;GO:2000811,negative regulation of anoikis;GO:0043066,negative regulation of apoptotic process;GO:0022408,negative regulation of cell-cell adhesion;GO:0038007,netrin-activated signaling pathway;GO:0018108,peptidyl-tyrosine phosphorylation;GO:0001890,placenta development;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0010763,positive regulation of fibroblast migration;GO:0010759,positive regulation of macrophage chemotaxis;GO:0120041,positive regulation of macrophage proliferation;GO:0043552,positive regulation of phosphatidylinositol 3-kinase activity;GO:0014068,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0045860,positive regulation of protein kinase activity;GO:0051897,positive regulation of protein kinase B signaling;GO:0001934,positive regulation of protein phosphorylation;GO:2000060,positive regulation of ubiquitin-dependent protein catabolic process;GO:0090303,positive regulation of wound healing;GO:0046777,protein autophosphorylation;GO:0030155,regulation of cell adhesion;GO:0033628,regulation of cell adhesion mediated by integrin;GO:0042127,regulation of cell population proliferation;GO:0008360,regulation of cell shape;GO:0051493,regulation of cytoskeleton organization;GO:0010594,regulation of endothelial cell migration;GO:0010632,regulation of epithelial cell migration;GO:0051893,regulation of focal adhesion assembly;GO:0043087,regulation of GTPase activity;GO:0045667,regulation of osteoblast differentiation;GO:0001932,regulation of protein phosphorylation;GO:1900024,regulation of substrate adhesion-dependent cell spreading;GO:0007172,signal complex assembly;GO:0007179,transforming growth factor beta receptor signaling pathway;GO:0007169,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0048010,vascular endothelial growth factor receptor signaling pathway	hsa:5747,path:hsa04012,ErbB signaling pathway;hsa:5747,path:hsa04370,VEGF signaling pathway;hsa:5747,path:hsa04151,PI3K-Akt signaling pathway;hsa:5747,path:hsa04510,Focal adhesion;hsa:5747,path:hsa04810,Regulation of actin cytoskeleton;hsa:5747,path:hsa04670,Leukocyte transendothelial migration;hsa:5747,path:hsa04062,Chemokine signaling pathway;hsa:5747,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:5747,path:hsa04360,Axon guidance;hsa:5747,path:hsa05200,Pathways in cancer;hsa:5747,path:hsa05202,Transcriptional misregulation in cancer;hsa:5747,path:hsa05205,Proteoglycans in cancer;hsa:5747,path:hsa05222,Small cell lung cancer;hsa:5747,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:5747,path:hsa05131,Shigellosis;hsa:5747,path:hsa05135,Yersinia infection;hsa:5747,path:hsa05100,Bacterial invasion of epithelial cells;hsa:5747,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:5747,path:hsa05163,Human cytomegalovirus infection;hsa:5747,path:hsa05165,Human papillomavirus infection;hsa:5747,path:hsa05146,Amoebiasis;hsa:5747,path:hsa01522,Endocrine resistance
STAT1_HUMAN	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	19.38580305	6.495299564	21.31404701	11.61278121	12.940551307	16.46341411	12.940551307	16.46341411	0.786018697005247	0.474634	0	1.27223436771928	0.474754	0	GO:0030424,axon;GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0032991,protein-containing complex	GO:0045296,cadherin binding;GO:0003700,DNA-binding transcription factor activity;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003690,double-stranded DNA binding;GO:0019899,enzyme binding;GO:0035035,histone acetyltransferase binding;GO:0042393,histone binding;GO:0042802,identical protein binding;GO:0035257,nuclear hormone receptor binding;GO:1990841,promoter-specific chromatin binding;GO:0042803,protein homodimerization activity;GO:0070491,repressing transcription factor binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000979,RNA polymerase II core promoter sequence-specific DNA binding;GO:0005164,tumor necrosis factor receptor binding;GO:0044389,ubiquitin-like protein ligase binding;GO:0003677,DNA binding;GO:0031730,CCR5 chemokine receptor binding;GO:0051721,protein phosphatase 2A binding;GO:0043565,sequence-specific DNA binding	GO:0008015,blood circulation;GO:0035458,cellular response to interferon-beta;GO:0071346,cellular response to interferon-gamma;GO:0019221,cytokine-mediated signaling pathway;GO:0006952,defense response;GO:0051607,defense response to virus;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0038114,interleukin-21-mediated signaling pathway;GO:0070106,interleukin-27-mediated signaling pathway;GO:0070757,interleukin-35-mediated signaling pathway;GO:0070102,interleukin-6-mediated signaling pathway;GO:0038113,interleukin-9-mediated signaling pathway;GO:0010742,macrophage derived foam cell differentiation;GO:0072162,metanephric mesenchymal cell differentiation;GO:0072136,metanephric mesenchymal cell proliferation involved in metanephros development;GO:0046725,negative regulation by virus of viral protein levels in host cell;GO:0016525,negative regulation of angiogenesis;GO:0001937,negative regulation of endothelial cell proliferation;GO:0043124,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0003340,negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0072308,negative regulation of metanephric nephron tubule epithelial cell differentiation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0002230,positive regulation of defense response to virus by host;GO:0045648,positive regulation of erythrocyte differentiation;GO:0032727,positive regulation of interferon-alpha production;GO:0002053,positive regulation of mesenchymal cell proliferation;GO:0048661,positive regulation of smooth muscle cell proliferation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0007221,positive regulation of transcription of Notch receptor target;GO:0045893,positive regulation of transcription, DNA-templated;GO:0007259,receptor signaling pathway via JAK-STAT;GO:0042981,regulation of apoptotic process;GO:0042127,regulation of cell population proliferation;GO:0060334,regulation of interferon-gamma-mediated signaling pathway;GO:0006355,regulation of transcription, DNA-templated;GO:0061326,renal tubule development;GO:0051591,response to cAMP;GO:0034097,response to cytokine;GO:0035456,response to interferon-beta;GO:0043434,response to peptide hormone;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process;GO:0007165,signal transduction;GO:0071345,cellular response to cytokine stimulus;GO:0032869,cellular response to insulin stimulus;GO:0071407,cellular response to organic cyclic compound;GO:0051770,positive regulation of nitric-oxide synthase biosynthetic process;GO:0042493,response to drug;GO:0042542,response to hydrogen peroxide;GO:0009612,response to mechanical stimulus;GO:0007584,response to nutrient	hsa:6772,path:hsa04630,Jak-STAT signaling pathway;hsa:6772,path:hsa04217,Necroptosis;hsa:6772,path:hsa04620,Toll-like receptor signaling pathway;hsa:6772,path:hsa04621,NOD-like receptor signaling pathway;hsa:6772,path:hsa04625,C-type lectin receptor signaling pathway;hsa:6772,path:hsa04658,Th1 and Th2 cell differentiation;hsa:6772,path:hsa04659,Th17 cell differentiation;hsa:6772,path:hsa04062,Chemokine signaling pathway;hsa:6772,path:hsa04917,Prolactin signaling pathway;hsa:6772,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:6772,path:hsa04919,Thyroid hormone signaling pathway;hsa:6772,path:hsa04380,Osteoclast differentiation;hsa:6772,path:hsa05200,Pathways in cancer;hsa:6772,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:6772,path:hsa05212,Pancreatic cancer;hsa:6772,path:hsa05321,Inflammatory bowel disease (IBD);hsa:6772,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:6772,path:hsa05152,Tuberculosis;hsa:6772,path:hsa05162,Measles;hsa:6772,path:hsa05164,Influenza A;hsa:6772,path:hsa05161,Hepatitis B;hsa:6772,path:hsa05160,Hepatitis C;hsa:6772,path:hsa05168,Herpes simplex virus 1 infection;hsa:6772,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:6772,path:hsa05169,Epstein-Barr virus infection;hsa:6772,path:hsa05165,Human papillomavirus infection;hsa:6772,path:hsa05145,Toxoplasmosis;hsa:6772,path:hsa05140,Leishmaniasis
G3BP2_HUMAN	Q9UN86	G3BP2	Ras GTPase-activating protein-binding protein 2	0.03113244	2.55E-05	0.059078877	0.040286383	0.01557897	0.04968263	0.01557897	0.04968263	0.313569752647958	0.071053	0	3.18908310369684	0.071313	0	GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:1990904,ribonucleoprotein complex	GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0030159,signaling receptor complex adaptor activity	GO:0007253,cytoplasmic sequestering of NF-kappaB;GO:0045087,innate immune response;GO:0051028,mRNA transport;GO:0062029,positive regulation of stress granule assembly;GO:0051260,protein homooligomerization;GO:0007265,Ras protein signal transduction;GO:0034063,stress granule assembly;GO:0016032,viral process	
INT11_HUMAN	Q5TA45	INTS11	Integrator complex subunit 11	0.034602158	2.55E-05	0.052192034	0.026135058	0.017313829	0.039163546	0.017313829	0.039163546	0.442090432771333	0.172825	0	2.26198063986886	0.173160	0	GO:0072562,blood microparticle;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0032039,integrator complex;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0004521,endoribonuclease activity	GO:0016180,snRNA processing;GO:0042795,snRNA transcription by RNA polymerase II	
CDK2_HUMAN	P24941	CDK2	Cyclin-dependent kinase 2	2.55E-05	2.55E-05	2.55E-05	2.55E-05	2.55e-005	2.55e-005	2.55e-005	2.55e-005	1	0.433351	0	1	0.433154	0	GO:0015030,Cajal body;GO:0005813,centrosome;GO:0097123,cyclin A1-CDK2 complex;GO:0097124,cyclin A2-CDK2 complex;GO:0097134,cyclin E1-CDK2 complex;GO:0097135,cyclin E2-CDK2 complex;GO:0000307,cyclin-dependent protein kinase holoenzyme complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005768,endosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000781,chromosome, telomeric region;GO:0000793,condensed chromosome;GO:0005667,transcription regulator complex;GO:0000805,X chromosome;GO:0000806,Y chromosome	GO:0005524,ATP binding;GO:0030332,cyclin binding;GO:0097472,cyclin-dependent protein kinase activity;GO:0004693,cyclin-dependent protein serine/threonine kinase activity;GO:0046872,metal ion binding;GO:0019904,protein domain specific binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0000287,magnesium ion binding;GO:0004672,protein kinase activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0051301,cell division;GO:0071732,cellular response to nitric oxide;GO:0007099,centriole replication;GO:0051298,centrosome duplication;GO:0006281,DNA repair;GO:0006260,DNA replication;GO:0006270,DNA replication initiation;GO:0000082,G1/S transition of mitotic cell cycle;GO:0000086,G2/M transition of mitotic cell cycle;GO:0030851,granulocyte differentiation;GO:0016572,histone phosphorylation;GO:0051321,meiotic cell cycle;GO:0031571,mitotic G1 DNA damage checkpoint;GO:0018105,peptidyl-serine phosphorylation;GO:0008284,positive regulation of cell population proliferation;GO:0006468,protein phosphorylation;GO:0007265,Ras protein signal transduction;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0010468,regulation of gene expression;GO:0060968,regulation of gene silencing;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0007165,signal transduction;GO:0007004,telomere maintenance via telomerase;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0032298,positive regulation of DNA-dependent DNA replication initiation;GO:0045893,positive regulation of transcription, DNA-templated;GO:0006813,potassium ion transport	hsa:1017,path:hsa04068,FoxO signaling pathway;hsa:1017,path:hsa04151,PI3K-Akt signaling pathway;hsa:1017,path:hsa04110,Cell cycle;hsa:1017,path:hsa04114,Oocyte meiosis;hsa:1017,path:hsa04115,p53 signaling pathway;hsa:1017,path:hsa04218,Cellular senescence;hsa:1017,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:1017,path:hsa05200,Pathways in cancer;hsa:1017,path:hsa05203,Viral carcinogenesis;hsa:1017,path:hsa05226,Gastric cancer;hsa:1017,path:hsa05215,Prostate cancer;hsa:1017,path:hsa05222,Small cell lung cancer;hsa:1017,path:hsa04934,Cushing syndrome;hsa:1017,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:1017,path:hsa05162,Measles;hsa:1017,path:hsa05161,Hepatitis B;hsa:1017,path:hsa05160,Hepatitis C;hsa:1017,path:hsa05169,Epstein-Barr virus infection;hsa:1017,path:hsa05165,Human papillomavirus infection
1433S_HUMAN	P31947	SFN	14-3-3 protein sigma	3.008884665	5.772380537	3.038617741	1.520960048	4.390632601	2.2797888945	4.390632601	2.2797888945	1.92589437188348	0.235685	0	0.519239276358664	0.235151	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0051219,phosphoprotein binding;GO:0019901,protein kinase binding;GO:0008426,protein kinase C inhibitor activity	GO:0006977,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0061436,establishment of skin barrier;GO:0008630,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0031424,keratinization;GO:0003334,keratinocyte development;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0010839,negative regulation of keratinocyte proliferation;GO:0006469,negative regulation of protein kinase activity;GO:0030307,positive regulation of cell growth;GO:0045606,positive regulation of epidermal cell differentiation;GO:0046827,positive regulation of protein export from nucleus;GO:1900740,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0000079,regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0010482,regulation of epidermal cell division;GO:0001836,release of cytochrome c from mitochondria;GO:0007165,signal transduction	hsa:2810,path:hsa04110,Cell cycle;hsa:2810,path:hsa04115,p53 signaling pathway;hsa:2810,path:hsa04960,Aldosterone-regulated sodium reabsorption
CAND1_HUMAN	Q86VP6	CAND1	Cullin-associated NEDD8-dissociated protein 1	8.993627638	6.017284232	18.190254	17.75410984	7.505455935	17.97218192	7.505455935	17.97218192	0.417615177078065	0.151482	0	2.39454898884834	0.151813	0	GO:0031461,cullin-RING ubiquitin ligase complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005794,Golgi apparatus;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0034774,secretory granule lumen;GO:0000151,ubiquitin ligase complex	GO:0017025,TBP-class protein binding	GO:0030154,cell differentiation;GO:0006879,cellular iron ion homeostasis;GO:0043086,negative regulation of catalytic activity;GO:0043312,neutrophil degranulation;GO:0045899,positive regulation of RNA polymerase II transcription preinitiation complex assembly;GO:0043687,post-translational protein modification;GO:0016567,protein ubiquitination;GO:0010265,SCF complex assembly	
CNIH4_HUMAN	Q9P003	CNIH4	Protein cornichon homolog 4	1.043912675	1.079646464	0.729791606	0.724822832	1.0617795695	0.727307219	1.0617795695	0.727307219	1.45987767172156	0.313218	0	0.684988899666335	0.312789	0	GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0016021,integral component of membrane	GO:0031730,CCR5 chemokine receptor binding	GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0015031,protein transport;GO:0016192,vesicle-mediated transport	
DCTN2_HUMAN	Q13561	DCTN2	Dynactin subunit 2	3.168946708	2.165105028	3.396395213	3.082903107	2.667025868	3.23964916	2.667025868	3.23964916	0.823245276349616	0.498440	0	1.21470481365425	0.498386	0	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005869,dynactin complex;GO:0030286,dynein complex;GO:0070062,extracellular exosome;GO:0030426,growth cone;GO:0000776,kinetochore;GO:0016020,membrane;GO:0005874,microtubule;GO:0031982,vesicle;GO:0005815,microtubule organizing center	GO:0042802,identical protein binding;GO:0019901,protein kinase binding;GO:0030507,spectrin binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0097711,ciliary basal body-plasma membrane docking;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0000086,G2/M transition of mitotic cell cycle;GO:0032402,melanosome transport;GO:0007080,mitotic metaphase plate congression;GO:0007052,mitotic spindle organization;GO:0071539,protein localization to centrosome;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0007017,microtubule-based process	hsa:10540,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:10540,path:hsa05016,Huntington disease
MYL9_HUMAN	P24844	MYL9	Myosin regulatory light polypeptide 9	2.957384564	4.615894263	0.294639337	0.372145428	3.7866394135	0.3333923825	3.7866394135	0.3333923825	11.3579062158086	0.013348	1	0.0880443966519232	0.013175	-1	GO:0005938,cell cortex;GO:0005829,cytosol;GO:0005859,muscle myosin complex;GO:0001725,stress fiber;GO:0030018,Z disc	GO:0005509,calcium ion binding;GO:0032036,myosin heavy chain binding;GO:0008307,structural constituent of muscle	GO:0006936,muscle contraction;GO:0070527,platelet aggregation;GO:0045652,regulation of megakaryocyte differentiation;GO:0006937,regulation of muscle contraction	hsa:10398,path:hsa04024,cAMP signaling pathway;hsa:10398,path:hsa04022,cGMP-PKG signaling pathway;hsa:10398,path:hsa04510,Focal adhesion;hsa:10398,path:hsa04530,Tight junction;hsa:10398,path:hsa04810,Regulation of actin cytoskeleton;hsa:10398,path:hsa04670,Leukocyte transendothelial migration;hsa:10398,path:hsa04921,Oxytocin signaling pathway;hsa:10398,path:hsa04270,Vascular smooth muscle contraction;hsa:10398,path:hsa04360,Axon guidance;hsa:10398,path:hsa05132,Salmonella infection;hsa:10398,path:hsa05131,Shigellosis
RAB1A_HUMAN	P62820	RAB1A	Ras-related protein Rab-1A	43.61120799	117.093641	9.642870391	3.929094575	80.352424495	6.785982483	80.352424495	6.785982483	11.8409419264338	0.012192	1	0.0844527408556572	0.012029	-1	GO:0005829,cytosol;GO:0005769,early endosome;GO:0012505,endomembrane system;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0042470,melanosome;GO:0030658,transport vesicle membrane	GO:0045296,cadherin binding;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0000045,autophagosome assembly;GO:0006914,autophagy;GO:0016477,cell migration;GO:0048208,COPII vesicle coating;GO:0090110,COPII-coated vesicle cargo loading;GO:0042742,defense response to bacterium;GO:0006897,endocytosis;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030,Golgi organization;GO:0030252,growth hormone secretion;GO:0006886,intracellular protein transport;GO:0032402,melanosome transport;GO:1903020,positive regulation of glycoprotein metabolic process;GO:0032757,positive regulation of interleukin-8 production;GO:1904668,positive regulation of ubiquitin protein ligase activity;GO:0043687,post-translational protein modification;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0034446,substrate adhesion-dependent cell spreading;GO:0047496,vesicle transport along microtubule;GO:0016192,vesicle-mediated transport;GO:0019068,virion assembly	hsa:5861,path:hsa04140,Autophagy - animal;hsa:5861,path:hsa05130,Pathogenic Escherichia coli infection;hsa:5861,path:hsa05134,Legionellosis
LIMS1_HUMAN	P48059	LIMS1	LIM and senescent cell antigen-like-containing domain protein 1	1.917311007	1.351816915	1.081771918	3.800045691	1.634563961	2.4409088045	1.634563961	2.4409088045	0.669653842858266	0.378860	0	1.49330883510162	0.379082	0	GO:0005911,cell-cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0032991,protein-containing complex	GO:0019901,protein kinase binding;GO:0044877,protein-containing complex binding;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0007569,cell aging;GO:0034329,cell junction assembly;GO:0098609,cell-cell adhesion;GO:0045216,cell-cell junction organization;GO:0071560,cellular response to transforming growth factor beta stimulus;GO:0045184,establishment of protein localization;GO:0045892,negative regulation of transcription, DNA-templated;GO:0010811,positive regulation of cell-substrate adhesion;GO:0051894,positive regulation of focal adhesion assembly;GO:0010628,positive regulation of gene expression;GO:0043547,positive regulation of GTPase activity;GO:2001046,positive regulation of integrin-mediated signaling pathway;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0033209,tumor necrosis factor-mediated signaling pathway	
VPS53_HUMAN	Q5VIR6	VPS53	Vacuolar protein sorting-associated protein 53 homolog	0.138724009	0.119592817	0.23380546	0.126385445	0.129158413	0.1800954525	0.129158413	0.1800954525	0.717166431506648	0.419286	0	1.39437647395064	0.419466	0	GO:0005829,cytosol;GO:1990745,EARP complex;GO:0010008,endosome membrane;GO:0000938,GARP complex;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm;GO:0055037,recycling endosome;GO:0032588,trans-Golgi network membrane		GO:0032456,endocytic recycling;GO:0007041,lysosomal transport;GO:0015031,protein transport;GO:0042147,retrograde transport, endosome to Golgi	
URP2_HUMAN	Q86UX7	FERMT3	Fermitin family homolog 3	5.271087856	9.186327308	8.062630443	9.063440128	7.228707582	8.5630352855	7.228707582	8.5630352855	0.844175848982025	0.489999	0	1.18458731223581	0.489926	0	GO:0042995,cell projection;GO:0030055,cell-substrate junction;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0016020,membrane;GO:0031093,platelet alpha granule lumen;GO:0002102,podosome	GO:0005178,integrin binding	GO:0007160,cell-matrix adhesion;GO:0033622,integrin activation;GO:0007229,integrin-mediated signaling pathway;GO:0007159,leukocyte cell-cell adhesion;GO:0070527,platelet aggregation;GO:0002576,platelet degranulation;GO:0030335,positive regulation of cell migration;GO:0033632,regulation of cell-cell adhesion mediated by integrin;GO:0034446,substrate adhesion-dependent cell spreading	hsa:83706,path:hsa04611,Platelet activation
TOP2A_HUMAN	P11388	TOP2A	DNA topoisomerase 2-alpha	0.083345528	0.067724096	0.100293105	0.131213234	0.075534812	0.1157531695	0.075534812	0.1157531695	0.652550701862207	0.363915	0	1.53244797246599	0.364150	0	GO:0000775,chromosome, centromeric region;GO:0000793,condensed chromosome;GO:0005737,cytoplasm;GO:0009330,DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:1990904,ribonucleoprotein complex	GO:0005524,ATP binding;GO:0008094,ATPase activity, acting on DNA;GO:0003682,chromatin binding;GO:0003677,DNA binding;GO:0008301,DNA binding, bending;GO:0003918,DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity;GO:0019899,enzyme binding;GO:0042826,histone deacetylase binding;GO:0000287,magnesium ion binding;GO:0008022,protein C-terminus binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0005080,protein kinase C binding;GO:0003723,RNA binding;GO:0043130,ubiquitin binding	GO:0030263,apoptotic chromosome condensation;GO:0006974,cellular response to DNA damage stimulus;GO:0007059,chromosome segregation;GO:0006266,DNA ligation;GO:0006265,DNA topological change;GO:0040016,embryonic cleavage;GO:0007143,female meiotic nuclear division;GO:0002244,hematopoietic progenitor cell differentiation;GO:1905463,negative regulation of DNA duplex unwinding;GO:0043065,positive regulation of apoptotic process;GO:0045870,positive regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0042752,regulation of circadian rhythm;GO:0000712,resolution of meiotic recombination intermediates;GO:0048511,rhythmic process;GO:0000819,sister chromatid segregation	hsa:7153,path:hsa01524,Platinum drug resistance
XRCC5_HUMAN	P13010	XRCC5	X-ray repair cross-complementing protein 5	14.49364676	9.432037946	22.47495764	15.27883761	11.962842353	18.876897625	11.962842353	18.876897625	0.63372925947094	0.347256	0	1.57796091162784	0.347506	0	GO:0000781,chromosome, telomeric region;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0043564,Ku70;GO:0016020,membrane;GO:0070419,nonhomologous end joining complex;GO:0000783,nuclear telomere cap complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0032993,protein-DNA complex;GO:1990904,ribonucleoprotein complex;GO:0034774,secretory granule lumen;GO:0090734,site of DNA damage;GO:0032040,small-subunit processome	GO:0005524,ATP binding;GO:0008094,ATPase activity, acting on DNA;GO:0003684,damaged DNA binding;GO:0003677,DNA binding;GO:0045027,DNA end binding;GO:0003678,DNA helicase activity;GO:0003690,double-stranded DNA binding;GO:0008047,enzyme activator activity;GO:0008022,protein C-terminus binding;GO:0044877,protein-containing complex binding;GO:0003723,RNA binding;GO:0042162,telomeric DNA binding;GO:0000976,transcription regulatory region sequence-specific DNA binding;GO:0034511,U3 snoRNA binding;GO:0031625,ubiquitin protein ligase binding	GO:0002218,activation of innate immune response;GO:0007420,brain development;GO:0008283,cell population proliferation;GO:0071475,cellular hyperosmotic salinity response;GO:0006974,cellular response to DNA damage stimulus;GO:0071398,cellular response to fatty acid;GO:0071480,cellular response to gamma radiation;GO:1990830,cellular response to leukemia inhibitory factor;GO:0071481,cellular response to X-ray;GO:0006310,DNA recombination;GO:0006302,double-strand break repair;GO:0006303,double-strand break repair via nonhomologous end joining;GO:0075713,establishment of integrated proviral latency;GO:0060218,hematopoietic stem cell differentiation;GO:0045087,innate immune response;GO:1904430,negative regulation of t-circle formation;GO:0045892,negative regulation of transcription, DNA-templated;GO:0043312,neutrophil degranulation;GO:0043085,positive regulation of catalytic activity;GO:0050769,positive regulation of neurogenesis;GO:0045860,positive regulation of protein kinase activity;GO:0051973,positive regulation of telomerase activity;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:0032481,positive regulation of type I interferon production;GO:0070198,protein localization to chromosome, telomeric region;GO:0048660,regulation of smooth muscle cell proliferation;GO:0032204,regulation of telomere maintenance;GO:0042493,response to drug;GO:0034462,small-subunit processome assembly;GO:0000723,telomere maintenance	hsa:7520,path:hsa03450,Non-homologous end-joining
CFAI_HUMAN	P05156	CFI	Complement factor I	0.496952346	0.255083379	0.498896672	1.981950914	0.3760178625	1.240423793	0.3760178625	1.240423793	0.303136609134681	0.064293	0	3.2988427325045	0.064541	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0016020,membrane	GO:0046872,metal ion binding;GO:0005044,scavenger receptor activity;GO:0004252,serine-type endopeptidase activity	GO:0006958,complement activation, classical pathway;GO:0045087,innate immune response;GO:0030449,regulation of complement activation;GO:0016032,viral process	hsa:3426,path:hsa04610,Complement and coagulation cascades;hsa:3426,path:hsa05150,Staphylococcus aureus infection
VATC1_HUMAN	P21283	ATP6V1C1	V-type proton ATPase subunit C 1	3.701347841	3.56593562	5.858363998	31.90779622	3.6336417305	18.883080109	3.6336417305	18.883080109	0.192428444381176	0.013407	-1	5.1967369128606	0.013503	1	GO:0045177,apical part of cell;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005765,lysosomal membrane;GO:0005886,plasma membrane;GO:0016469,proton-transporting two-sector ATPase complex;GO:0000221,vacuolar proton-transporting V-type ATPase, V1 domain;GO:0033180,proton-transporting V-type ATPase, V1 domain	GO:0046961,proton-transporting ATPase activity, rotational mechanism;GO:0005215,transporter activity;GO:0015078,proton transmembrane transporter activity	GO:0034198,cellular response to amino acid starvation;GO:0008286,insulin receptor signaling pathway;GO:0034220,ion transmembrane transport;GO:0090383,phagosome acidification;GO:1902600,proton transmembrane transport;GO:0016241,regulation of macroautophagy;GO:0033572,transferrin transport	hsa:528,path:hsa00190,Oxidative phosphorylation;hsa:528,path:hsa04150,mTOR signaling pathway;hsa:528,path:hsa04145,Phagosome;hsa:528,path:hsa04966,Collecting duct acid secretion;hsa:528,path:hsa04721,Synaptic vesicle cycle;hsa:528,path:hsa05323,Rheumatoid arthritis;hsa:528,path:hsa05110,Vibrio cholerae infection;hsa:528,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:528,path:hsa05165,Human papillomavirus infection
SCYL1_HUMAN	Q96KG9	SCYL1	N-terminal kinase-like protein	0.270914206	0.856847645	0.545756963	0.86321724	0.5638809255	0.7044871015	0.5638809255	0.7044871015	0.800413413246857	0.485684	0	1.24935437543897	0.485791	0	GO:0005801,cis-Golgi network;GO:0030126,COPI vesicle coat;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,Golgi apparatus;GO:0016020,membrane;GO:0005815,microtubule organizing center;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0003677,DNA binding;GO:0004713,protein tyrosine kinase activity;GO:0004672,protein kinase activity	GO:0034613,cellular protein localization;GO:0006954,inflammatory response;GO:0048666,neuron development;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0021522,spinal cord motor neuron differentiation	
CTBL1_HUMAN	Q8WYA6	CTNNBL1	Beta-catenin-like protein 1	0.155542253	0.086080281	0.177380603	0.333999761	0.120811267	0.255690182	0.120811267	0.255690182	0.472490832674991	0.200054	0	2.11644317909521	0.200388	0	GO:0005813,centrosome;GO:0005829,cytosol;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000974,Prp19 complex;GO:0005681,spliceosomal complex	GO:0019899,enzyme binding	GO:0006915,apoptotic process;GO:0000398,mRNA splicing, via spliceosome;GO:0043065,positive regulation of apoptotic process;GO:0016445,somatic diversification of immunoglobulins	hsa:56259,path:hsa03040,Spliceosome
MYOF_HUMAN	Q9NZM1	MYOF	Myoferlin	7.748606275	6.653718229	6.6756508	8.790119189	7.201162252	7.7328849945	7.201162252	7.7328849945	0.931238762392278	0.457076	0	1.07383846161115	0.456930	0	GO:0005901,caveola;GO:0031410,cytoplasmic vesicle;GO:0030659,cytoplasmic vesicle membrane;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0005886,plasma membrane	GO:0046872,metal ion binding;GO:0005543,phospholipid binding	GO:0008015,blood circulation;GO:0061025,membrane fusion;GO:0006936,muscle contraction;GO:0007520,myoblast fusion;GO:0007009,plasma membrane organization;GO:0001778,plasma membrane repair;GO:0033292,T-tubule organization	
STK25_HUMAN	O00506	STK25	Serine/threonine-protein kinase 25	2.55E-05	0.048373935	0.041364113	2.55E-05	0.0241997175	0.0206948065	0.0241997175	0.0206948065	1.16936186380868	0.382195	0	0.855167276229568	0.381892	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0000139,Golgi membrane	GO:0005524,ATP binding;GO:0046872,metal ion binding;GO:0042803,protein homodimerization activity;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0106311,protein threonine kinase activity	GO:0051683,establishment of Golgi localization;GO:0007163,establishment or maintenance of cell polarity;GO:0051645,Golgi localization;GO:0090168,Golgi reassembly;GO:0036481,intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:0050772,positive regulation of axonogenesis;GO:0032874,positive regulation of stress-activated MAPK cascade;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:0042542,response to hydrogen peroxide;GO:0006979,response to oxidative stress;GO:0007165,signal transduction	
HNRLL_HUMAN	Q8WVV9	HNRNPLL	Heterogeneous nuclear ribonucleoprotein L-like	0.126850185	0.036534035	0.074517704	0.030715189	0.08169211	0.0526164465	0.08169211	0.0526164465	1.55259648710789	0.295065	0	0.644082353852777	0.294607	0	GO:0016020,membrane;GO:0005634,nucleus	GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0003676,nucleic acid binding	GO:0006397,mRNA processing;GO:0033120,positive regulation of RNA splicing;GO:0043484,regulation of RNA splicing	
LIPB1_HUMAN	Q86W92	PPFIBP1	Liprin-beta-1	0.19672337	0.221727159	0.211679494	0.396359254	0.2092252645	0.304019374	0.2092252645	0.304019374	0.688197142659731	0.394837	0	1.45307200221033	0.395043	0	GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005886,plasma membrane;GO:0048786,presynaptic active zone	GO:0045296,cadherin binding	GO:0007155,cell adhesion;GO:0007528,neuromuscular junction development;GO:0050808,synapse organization	
CHM4B_HUMAN	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.577860723	0.036929284	0.201188408	0.641246351	0.3073950035	0.4212173795	0.3073950035	0.4212173795	0.729777588628676	0.429722	0	1.37028050132246	0.429891	0	GO:0005737,cytoplasm;GO:0009898,cytoplasmic side of plasma membrane;GO:0005829,cytosol;GO:0005768,endosome;GO:0000815,ESCRT III complex;GO:0070062,extracellular exosome;GO:0031902,late endosome membrane;GO:0030117,membrane coat;GO:0030496,midbody;GO:0005771,multivesicular body;GO:0005635,nuclear envelope;GO:0005634,nucleus;GO:0031982,vesicle	GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity	GO:0006914,autophagy;GO:0016197,endosomal transport;GO:0010458,exit from mitosis;GO:0032511,late endosome to vacuole transport via multivesicular body sorting pathway;GO:0016236,macroautophagy;GO:0036438,maintenance of lens transparency;GO:0090148,membrane fission;GO:0061952,midbody abscission;GO:0000281,mitotic cytokinesis;GO:0007080,mitotic metaphase plate congression;GO:0007084,mitotic nuclear envelope reassembly;GO:0036258,multivesicular body assembly;GO:1902902,negative regulation of autophagosome assembly;GO:0060548,negative regulation of cell death;GO:1901215,negative regulation of neuron death;GO:0031468,nuclear envelope reassembly;GO:0006997,nucleus organization;GO:1902188,positive regulation of viral release from host cell;GO:0006620,posttranslational protein targeting to endoplasmic reticulum membrane;GO:0051258,protein polymerization;GO:0010824,regulation of centrosome duplication;GO:1901673,regulation of mitotic spindle assembly;GO:0050792,regulation of viral process;GO:0090611,ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;GO:0006900,vesicle budding from membrane;GO:0046755,viral budding;GO:0039702,viral budding via host ESCRT complex;GO:0019058,viral life cycle	hsa:128866,path:hsa04144,Endocytosis;hsa:128866,path:hsa04217,Necroptosis
RU17_HUMAN	P08621	SNRNP70	U1 small nuclear ribonucleoprotein 70 kDa	1.216214763	1.492160472	0.685537504	0.11679786	1.3541876175	0.401167682	1.3541876175	0.401167682	3.37561493176312	0.116384	0	0.296242320351892	0.115839	0	GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0005685,U1 snRNP;GO:0071004,U2-type prespliceosome	GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0017069,snRNA binding;GO:0030619,U1 snRNA binding	GO:0000398,mRNA splicing, via spliceosome;GO:1904715,negative regulation of chaperone-mediated autophagy;GO:0061084,negative regulation of protein refolding;GO:0048026,positive regulation of mRNA splicing, via spliceosome;GO:0043462,regulation of ATPase activity;GO:0043484,regulation of RNA splicing	hsa:6625,path:hsa03040,Spliceosome
STEA3_HUMAN	Q658P3	STEAP3	Metalloreductase STEAP3	0.311458998	0.747710086	1.015187993	0.775045449	0.529584542	0.895116721	0.529584542	0.895116721	0.591637413954643	0.309323	0	1.69022441179939	0.309604	0	GO:0005737,cytoplasm;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0016021,integral component of membrane;GO:0005771,multivesicular body;GO:0005886,plasma membrane	GO:0008823,cupric reductase activity;GO:0052851,ferric-chelate reductase (NADPH) activity;GO:0042802,identical protein binding;GO:0046872,metal ion binding	GO:0006915,apoptotic process;GO:0007049,cell cycle;GO:0015677,copper ion import;GO:0055072,iron ion homeostasis;GO:0009306,protein secretion;GO:0042981,regulation of apoptotic process;GO:0033572,transferrin transport	hsa:55240,path:hsa04216,Ferroptosis;hsa:55240,path:hsa04115,p53 signaling pathway
ADAS_HUMAN	O00116	AGPS	Alkyldihydroxyacetonephosphate synthase, peroxisomal	0.504242644	0.436662784	0.555790082	5.64839809	0.470452714	3.102094086	0.470452714	3.102094086	0.151656494276944	0.004967	-1	6.59384884747418	0.005013	1	GO:0005829,cytosol;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005782,peroxisomal matrix;GO:0005778,peroxisomal membrane;GO:0005777,peroxisome	GO:0008609,alkylglycerone-phosphate synthase activity;GO:0071949,FAD binding;GO:0016491,oxidoreductase activity;GO:0050660,flavin adenine dinucleotide binding	GO:0008611,ether lipid biosynthetic process;GO:0008610,lipid biosynthetic process;GO:0008104,protein localization	hsa:8540,path:hsa00565,Ether lipid metabolism;hsa:8540,path:hsa04146,Peroxisome
AT1B1_HUMAN	P05026	ATP1B1	Sodium/potassium-transporting ATPase subunit beta-1	3.529636216	0.982323905	3.140610318	2.171002562	2.2559800605	2.65580644	2.2559800605	2.65580644	0.849451988112507	0.487904	0	1.17722957152883	0.487827	0	GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0005901,caveola;GO:0070062,extracellular exosome;GO:1903561,extracellular vesicle;GO:0014704,intercalated disc;GO:0016328,lateral plasma membrane;GO:0016020,membrane;GO:0031090,organelle membrane;GO:0005886,plasma membrane;GO:0042383,sarcolemma;GO:0005890,sodium;GO:0036126,sperm flagellum;GO:0030315,T-tubule	GO:0001671,ATPase activator activity;GO:0051117,ATPase binding;GO:0023026,MHC class II protein complex binding;GO:0005391,P-type sodium;GO:0008022,protein C-terminus binding;GO:0046982,protein heterodimerization activity;GO:0019901,protein kinase binding;GO:0030674,protein-macromolecule adaptor activity	GO:0046034,ATP metabolic process;GO:0060048,cardiac muscle contraction;GO:0098655,cation transmembrane transport;GO:0007155,cell adhesion;GO:0086064,cell communication by electrical coupling involved in cardiac conduction;GO:0006874,cellular calcium ion homeostasis;GO:0030007,cellular potassium ion homeostasis;GO:0006883,cellular sodium ion homeostasis;GO:0010248,establishment or maintenance of transmembrane electrochemical gradient;GO:0034220,ion transmembrane transport;GO:0050900,leukocyte migration;GO:0086009,membrane repolarization;GO:0086013,membrane repolarization during cardiac muscle cell action potential;GO:0032781,positive regulation of ATPase activity;GO:1903281,positive regulation of calcium;GO:1903408,positive regulation of P-type sodium;GO:1903288,positive regulation of potassium ion import across plasma membrane;GO:1901018,positive regulation of potassium ion transmembrane transporter activity;GO:1903278,positive regulation of sodium ion export across plasma membrane;GO:1990573,potassium ion import across plasma membrane;GO:0072659,protein localization to plasma membrane;GO:0050821,protein stabilization;GO:0044861,protein transport into plasma membrane raft;GO:1903779,regulation of cardiac conduction;GO:0010882,regulation of cardiac muscle contraction by calcium ion signaling;GO:0010468,regulation of gene expression;GO:0055119,relaxation of cardiac muscle;GO:0001666,response to hypoxia;GO:0036376,sodium ion export across plasma membrane;GO:0035725,sodium ion transmembrane transport;GO:0006813,potassium ion transport;GO:0006814,sodium ion transport	hsa:481,path:hsa04024,cAMP signaling pathway;hsa:481,path:hsa04022,cGMP-PKG signaling pathway;hsa:481,path:hsa04911,Insulin secretion;hsa:481,path:hsa04918,Thyroid hormone synthesis;hsa:481,path:hsa04919,Thyroid hormone signaling pathway;hsa:481,path:hsa04925,Aldosterone synthesis and secretion;hsa:481,path:hsa04260,Cardiac muscle contraction;hsa:481,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:481,path:hsa04970,Salivary secretion;hsa:481,path:hsa04971,Gastric acid secretion;hsa:481,path:hsa04972,Pancreatic secretion;hsa:481,path:hsa04976,Bile secretion;hsa:481,path:hsa04973,Carbohydrate digestion and absorption;hsa:481,path:hsa04974,Protein digestion and absorption;hsa:481,path:hsa04978,Mineral absorption;hsa:481,path:hsa04960,Aldosterone-regulated sodium reabsorption;hsa:481,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:481,path:hsa04964,Proximal tubule bicarbonate reclamation
CAVN2_HUMAN	O95810	CAVIN2	Caveolae-associated protein 2	0.437763362	0.30139772	1.516147245	12.57416707	0.369580541	7.0451571575	0.369580541	7.0451571575	0.0524588071973042	0.000013	-1	19.0625760177671	0.000014	1	GO:0005901,caveola;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0045121,membrane raft;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0001786,phosphatidylserine binding;GO:0005543,phospholipid binding;GO:0005080,protein kinase C binding	GO:0097320,plasma membrane tubulation	
SPAT7_HUMAN	Q9P0W8	SPATA7	Spermatogenesis-associated protein 7	6.4121888	13.40062751	3.585366285	14.08823646	9.906408155	8.8368013725	9.906408155	8.8368013725	1.12104003897028	0.395832	0	0.892028799362548	0.395556	0	GO:0005930,axoneme;GO:0036064,ciliary basal body;GO:0005829,cytosol;GO:0015630,microtubule cytoskeleton;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0032391,photoreceptor connecting cilium;GO:0120206,photoreceptor distal connecting cilium;GO:0120200,rod photoreceptor outer segment		GO:0000226,microtubule cytoskeleton organization;GO:0045494,photoreceptor cell maintenance;GO:1903621,protein localization to photoreceptor connecting cilium;GO:1903546,protein localization to photoreceptor outer segment;GO:0050896,response to stimulus;GO:0007601,visual perception	
S4A7_HUMAN	Q9Y6M7	SLC4A7	Sodium bicarbonate cotransporter 3	0.027825787	2.55E-05	0.023017553	0.012336033	0.0139256435	0.017676793	0.0139256435	0.017676793	0.787792418002519	0.476006	0	1.26936992175622	0.476124	0	GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0031410,cytoplasmic vesicle;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0032420,stereocilium;GO:0045202,synapse	GO:0005452,inorganic anion exchanger activity;GO:0008510,sodium;GO:0022857,transmembrane transporter activity	GO:0060117,auditory receptor cell development;GO:0015701,bicarbonate transport;GO:0050801,ion homeostasis;GO:0051453,regulation of intracellular pH;GO:0055085,transmembrane transport	
GHDC_HUMAN	Q8N2G8	GHDC	GH3 domain-containing protein	0.205960706	0.204525244	0.200048509	0.133662376	0.205242975	0.1668554425	0.205242975	0.1668554425	1.23006461116784	0.366033	0	0.812965425491421	0.365699	0	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005576,extracellular region;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0034774,secretory granule lumen;GO:0035580,specific granule lumen	GO:0016881,acid-amino acid ligase activity	GO:0043312,neutrophil degranulation	
PI42A_HUMAN	P48426	PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0.282996787	0.477345007	0.943926432	0.86186615	0.380170897	0.902896291	0.380170897	0.902896291	0.421057103445339	0.154444	0	2.37497477614653	0.154777	0	GO:0005776,autophagosome;GO:0005829,cytosol;GO:0005764,lysosome;GO:0005654,nucleoplasm;GO:0001917,photoreceptor inner segment;GO:0001750,photoreceptor outer segment;GO:0005886,plasma membrane	GO:0016308,1-phosphatidylinositol-4-phosphate 5-kinase activity;GO:0016309,1-phosphatidylinositol-5-phosphate 4-kinase activity;GO:0005524,ATP binding;GO:0042803,protein homodimerization activity;GO:0016307,phosphatidylinositol phosphate kinase activity	GO:1902635,1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process;GO:0061909,autophagosome-lysosome fusion;GO:0035855,megakaryocyte development;GO:0090217,negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity;GO:0046627,negative regulation of insulin receptor signaling pathway;GO:0006661,phosphatidylinositol biosynthetic process;GO:0006644,phospholipid metabolic process;GO:2000786,positive regulation of autophagosome assembly;GO:0010506,regulation of autophagy;GO:0014066,regulation of phosphatidylinositol 3-kinase signaling;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0090119,vesicle-mediated cholesterol transport	hsa:5305,path:hsa00562,Inositol phosphate metabolism;hsa:5305,path:hsa04070,Phosphatidylinositol signaling system;hsa:5305,path:hsa04810,Regulation of actin cytoskeleton
ILF3_HUMAN	Q12906	ILF3	Interleukin enhancer-binding factor 3	12.29008853	11.86680713	13.28872006	40.04381274	12.07844783	26.6662664	12.07844783	26.6662664	0.452948592383372	0.182473	0	2.20775606065602	0.182809	0	GO:0005737,cytoplasm;GO:0005576,extracellular region;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex	GO:0003677,DNA binding;GO:0003725,double-stranded RNA binding;GO:0035925,mRNA 3'-UTR AU-rich region binding;GO:0003723,RNA binding;GO:0003727,single-stranded RNA binding	GO:0051607,defense response to virus;GO:0045892,negative regulation of transcription, DNA-templated;GO:0017148,negative regulation of translation;GO:0045071,negative regulation of viral genome replication;GO:0045893,positive regulation of transcription, DNA-templated;GO:0006468,protein phosphorylation	
GSTO1_HUMAN	P78417	GSTO1	Glutathione S-transferase omega-1	10.91156656	18.58376013	11.09760527	13.17958728	14.747663345	12.138596275	14.747663345	12.138596275	1.21493976823115	0.369964	0	0.823086070724243	0.369636	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm	GO:0045174,glutathione dehydrogenase (ascorbate) activity;GO:0004364,glutathione transferase activity;GO:0050610,methylarsonate reductase activity;GO:0016491,oxidoreductase activity	GO:0071243,cellular response to arsenic-containing substance;GO:1901687,glutathione derivative biosynthetic process;GO:0006749,glutathione metabolic process;GO:0035722,interleukin-12-mediated signaling pathway;GO:0019852,L-ascorbic acid metabolic process;GO:0032259,methylation;GO:0060315,negative regulation of ryanodine-sensitive calcium-release channel activity;GO:0060316,positive regulation of ryanodine-sensitive calcium-release channel activity;GO:0014810,positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion;GO:0010881,regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0010880,regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0042178,xenobiotic catabolic process	hsa:9446,path:hsa00480,Glutathione metabolism;hsa:9446,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:9446,path:hsa00982,Drug metabolism - cytochrome P450;hsa:9446,path:hsa00983,Drug metabolism - other enzymes;hsa:9446,path:hsa05200,Pathways in cancer;hsa:9446,path:hsa05204,Chemical carcinogenesis;hsa:9446,path:hsa05225,Hepatocellular carcinoma;hsa:9446,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:9446,path:hsa01524,Platinum drug resistance
NUB1_HUMAN	Q9Y5A7	NUB1	NEDD8 ultimate buster 1	0.03906523	0.042199994	0.115648177	0.044803835	0.040632612	0.080226006	0.040632612	0.080226006	0.50647681501183	0.231085	0	1.97442404145714	0.231411	0	GO:0005829,cytosol;GO:0005730,nucleolus;GO:0005654,nucleoplasm		GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043687,post-translational protein modification;GO:0016567,protein ubiquitination;GO:2000058,regulation of ubiquitin-dependent protein catabolic process;GO:0034341,response to interferon-gamma;GO:0034612,response to tumor necrosis factor;GO:0006511,ubiquitin-dependent protein catabolic process	
TTC37_HUMAN	Q6PGP7	TTC37	Tetratricopeptide repeat protein 37	0.850941139	0.560909292	1.454212451	0.940409013	0.7059252155	1.197310732	0.7059252155	1.197310732	0.589592322722118	0.307460	0	1.69608721392953	0.307743	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0055087,Ski complex;GO:0035327,transcriptionally active chromatin		GO:0043928,exonucleolytic catabolism of deadenylated mRNA;GO:0034427,nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';GO:0006401,RNA catabolic process	hsa:9652,path:hsa03018,RNA degradation
GSTM4_HUMAN	Q03013	GSTM4	Glutathione S-transferase Mu 4	0.711181464	0.668924093	1.649420053	1.761594558	0.6900527785	1.7055073055	0.6900527785	1.7055073055	0.404602651817841	0.140411	0	2.47156066700773	0.140738	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0045171,intercellular bridge	GO:0019899,enzyme binding;GO:0043295,glutathione binding;GO:0004364,glutathione transferase activity;GO:0004464,leukotriene-C4 synthase activity;GO:0042803,protein homodimerization activity	GO:1901687,glutathione derivative biosynthetic process;GO:0006749,glutathione metabolic process;GO:0042759,long-chain fatty acid biosynthetic process;GO:0018916,nitrobenzene metabolic process;GO:0042178,xenobiotic catabolic process	hsa:2948,path:hsa00480,Glutathione metabolism;hsa:2948,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:2948,path:hsa00982,Drug metabolism - cytochrome P450;hsa:2948,path:hsa00983,Drug metabolism - other enzymes;hsa:2948,path:hsa05200,Pathways in cancer;hsa:2948,path:hsa05204,Chemical carcinogenesis;hsa:2948,path:hsa05225,Hepatocellular carcinoma;hsa:2948,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:2948,path:hsa01524,Platinum drug resistance
PSMD8_HUMAN	P48556	PSMD8	26S proteasome non-ATPase regulatory subunit 8	1.565984957	1.627469101	1.466839435	1.586218905	1.596727029	1.52652917	1.596727029	1.52652917	1.04598527193555	0.418496	0	0.956036405894648	0.418267	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0022624,proteasome accessory complex;GO:0000502,proteasome complex;GO:0005838,proteasome regulatory particle;GO:0008541,proteasome regulatory particle, lid subcomplex		GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0006508,proteolysis	hsa:5714,path:hsa03050,Proteasome;hsa:5714,path:hsa05169,Epstein-Barr virus infection
UBP14_HUMAN	P54578	USP14	Ubiquitin carboxyl-terminal hydrolase 14	1.497476141	0.983422855	2.177898328	3.860895264	1.240449498	3.019396796	1.240449498	3.019396796	0.410826923988032	0.145680	0	2.43411505334819	0.146009	0	GO:0009986,cell surface;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0000502,proteasome complex	GO:0004197,cysteine-type endopeptidase activity;GO:0004866,endopeptidase inhibitor activity;GO:0070628,proteasome binding;GO:0004843,thiol-dependent deubiquitinase	GO:0045087,innate immune response;GO:1903070,negative regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0050920,regulation of chemotaxis;GO:0061136,regulation of proteasomal protein catabolic process	
H10_HUMAN	P07305	H1-0	Histone H1.0	0.740527655	1.090001966	0.227919135	0.142540945	0.9152648105	0.18523004	0.9152648105	0.18523004	4.94123313097595	0.064960	0	0.202378631708577	0.064516	0	GO:0015629,actin cytoskeleton;GO:0000785,chromatin;GO:0000791,euchromatin;GO:0005794,Golgi apparatus;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0000786,nucleosome;GO:0005634,nucleus;GO:0017053,transcription repressor complex;GO:0000792,heterochromatin;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0001673,male germ cell nucleus;GO:0005730,nucleolus	GO:0031490,chromatin DNA binding;GO:0003690,double-stranded DNA binding;GO:0003680,minor groove of adenine-thymine-rich DNA binding;GO:0031492,nucleosomal DNA binding;GO:0003723,RNA binding;GO:0005524,ATP binding;GO:0003677,DNA binding;GO:0043531,ADP binding;GO:0016208,AMP binding;GO:0005509,calcium ion binding;GO:0032564,dATP binding;GO:0005525,GTP binding;GO:0042826,histone deacetylase binding;GO:0042393,histone binding;GO:0003676,nucleic acid binding;GO:0045296,cadherin binding	GO:0006309,apoptotic DNA fragmentation;GO:0006342,chromatin silencing;GO:0030261,chromosome condensation;GO:0031936,negative regulation of chromatin silencing;GO:0045910,negative regulation of DNA recombination;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0006334,nucleosome assembly;GO:0016584,nucleosome positioning;GO:2000679,positive regulation of transcription regulatory region DNA binding;GO:0007275,multicellular organism development;GO:0035092,sperm chromatin condensation;GO:0007290,spermatid nucleus elongation;GO:0006325,chromatin organization;GO:0071169,establishment of protein localization to chromatin;GO:0030307,positive regulation of cell growth;GO:0051574,positive regulation of histone H3-K9 methylation;GO:0050821,protein stabilization;GO:0051321,meiotic cell cycle;GO:2000737,negative regulation of stem cell differentiation;GO:0044030,regulation of DNA methylation;GO:0006338,chromatin remodeling;GO:0007281,germ cell development;GO:0006355,regulation of transcription, DNA-templated;GO:0007283,spermatogenesis;GO:0030154,cell differentiation	
AGO2_HUMAN	Q9UKV8	AGO2	Protein argonaute-2	0.221433266	0.059985591	0.301643639	0.3268661	0.1407094285	0.3142548695	0.1407094285	0.3142548695	0.4477557618244	0.177847	0	2.23336042829568	0.178182	0	GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005845,mRNA cap binding complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body;GO:0005844,polysome;GO:1990904,ribonucleoprotein complex;GO:0016442,RISC complex;GO:0070578,RISC-loading complex	GO:0001046,core promoter sequence-specific DNA binding;GO:0003725,double-stranded RNA binding;GO:0004521,endoribonuclease activity;GO:0090624,endoribonuclease activity, cleaving miRNA-paired mRNA;GO:0070551,endoribonuclease activity, cleaving siRNA-paired mRNA;GO:0046872,metal ion binding;GO:0035198,miRNA binding;GO:0098808,mRNA cap binding;GO:0008022,protein C-terminus binding;GO:0000340,RNA 7-methylguanosine cap binding;GO:0003723,RNA binding;GO:0000993,RNA polymerase II complex binding;GO:0003727,single-stranded RNA binding;GO:0035197,siRNA binding;GO:0003743,translation initiation factor activity	GO:0031047,gene silencing by RNA;GO:0030522,intracellular receptor signaling pathway;GO:0035280,miRNA loading onto RISC involved in gene silencing by miRNA;GO:0035278,miRNA mediated inhibition of translation;GO:0010586,miRNA metabolic process;GO:0035279,mRNA cleavage involved in gene silencing by miRNA;GO:0090625,mRNA cleavage involved in gene silencing by siRNA;GO:0042985,negative regulation of amyloid precursor protein biosynthetic process;GO:0010629,negative regulation of gene expression;GO:0045947,negative regulation of translational initiation;GO:0045766,positive regulation of angiogenesis;GO:0010628,positive regulation of gene expression;GO:1905618,positive regulation of miRNA mediated inhibition of translation;GO:1900153,positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0060213,positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045975,positive regulation of translation, ncRNA-mediated;GO:1901165,positive regulation of trophoblast cell migration;GO:0009791,post-embryonic development;GO:0035194,post-transcriptional gene silencing by RNA;GO:0031054,pre-miRNA processing;GO:0035196,production of miRNAs involved in gene silencing by miRNA;GO:0030422,production of siRNA involved in RNA interference;GO:0060964,regulation of gene silencing by miRNA;GO:0010501,RNA secondary structure unwinding;GO:0035087,siRNA loading onto RISC involved in RNA interference;GO:0006412,translation;GO:0007223,Wnt signaling pathway, calcium modulating pathway	
CSKP_HUMAN	O14936	CASK	Peripheral plasma membrane protein CASK	0.328192637	0.351010008	0.426451592	0.152678444	0.3396013225	0.289565018	0.3396013225	0.289565018	1.17279816756042	0.381252	0	0.852661632376299	0.380947	0	GO:0015629,actin cytoskeleton;GO:0005604,basement membrane;GO:0005911,cell-cell junction;GO:0060170,ciliary membrane;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005652,nuclear lamina;GO:0016363,nuclear matrix;GO:0005730,nucleolus;GO:0005886,plasma membrane;GO:0042734,presynaptic membrane;GO:0016021,integral component of membrane;GO:0016323,basolateral plasma membrane;GO:0005634,nucleus;GO:0098685,Schaffer collateral - CA1 synapse;GO:0031982,vesicle	GO:0005524,ATP binding;GO:0005516,calmodulin binding;GO:0004385,guanylate kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0004672,protein kinase activity;GO:0042043,neurexin family protein binding	GO:0007155,cell adhesion;GO:0001953,negative regulation of cell-matrix adhesion;GO:0090288,negative regulation of cellular response to growth factor stimulus;GO:0010839,negative regulation of keratinocyte proliferation;GO:0061045,negative regulation of wound healing;GO:0006836,neurotransmitter transport;GO:0070509,calcium ion import;GO:0090280,positive regulation of calcium ion import;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:2000300,regulation of synaptic vesicle exocytosis	
K2C7_HUMAN	P08729	KRT7	Keratin, type II cytoskeletal 7	27.54822644	144.3040101	31.38131725	39.61937959	85.92611827	35.50034842	85.92611827	35.50034842	2.42043028010371	0.180649	0	0.413149681781849	0.180081	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005882,intermediate filament;GO:0045095,keratin filament;GO:0005634,nucleus		GO:0070268,cornification;GO:0031424,keratinization;GO:0016032,viral process	
AMPD3_HUMAN	Q01432	AMPD3	AMP deaminase 3	0.222481933	0.494733798	0.501252761	0.915372883	0.3586078655	0.708312822	0.3586078655	0.708312822	0.506284588336875	0.230908	0	1.97517369289269	0.231235	0	GO:0005829,cytosol;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0034774,secretory granule lumen	GO:0003876,AMP deaminase activity;GO:0046872,metal ion binding	GO:0006196,AMP catabolic process;GO:0046033,AMP metabolic process;GO:0006188,IMP biosynthetic process;GO:0032264,IMP salvage;GO:0043312,neutrophil degranulation;GO:0043101,purine-containing compound salvage	hsa:272,path:hsa00230,Purine metabolism
H33_HUMAN	P84243	H3-3A	Histone H3.3	59.0156095	408.1463148	27.84135004	72.69471111	233.58096215	50.268030575	233.58096215	50.268030575	4.64671003574522	0.071786	0	0.215206025834927	0.071322	0	GO:0000786,nucleosome;GO:0005634,nucleus;GO:0000781,chromosome, telomeric region;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0001740,Barr body;GO:0005576,extracellular region;GO:0000228,nuclear chromosome;GO:0032991,protein-containing complex;GO:0000791,euchromatin	GO:0003677,DNA binding;GO:0046982,protein heterodimerization activity;GO:0031492,nucleosomal DNA binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000979,RNA polymerase II core promoter sequence-specific DNA binding	GO:0045007,depurination;GO:0006302,double-strand break repair;GO:0006303,double-strand break repair via nonhomologous end joining;GO:0048239,negative regulation of DNA recombination at telomere;GO:0006334,nucleosome assembly;GO:1900051,positive regulation of histone exchange;GO:0016233,telomere capping;GO:1990000,amyloid fibril formation;GO:0007596,blood coagulation;GO:0008283,cell population proliferation;GO:0006336,DNA replication-independent nucleosome assembly;GO:0007566,embryo implantation;GO:0008584,male gonad development;GO:0035264,multicellular organism growth;GO:0042692,muscle cell differentiation;GO:1902340,negative regulation of chromosome condensation;GO:0045814,negative regulation of gene expression, epigenetic;GO:0006997,nucleus organization;GO:0048477,oogenesis;GO:0001649,osteoblast differentiation;GO:0031508,pericentric heterochromatin assembly;GO:0030307,positive regulation of cell growth;GO:0000183,rDNA heterochromatin assembly;GO:0060765,regulation of androgen receptor signaling pathway;GO:0090230,regulation of centromere complex assembly;GO:0060964,regulation of gene silencing by miRNA;GO:0045652,regulation of megakaryocyte differentiation;GO:0007338,single fertilization;GO:0007286,spermatid development;GO:0031509,subtelomeric heterochromatin assembly;GO:0032200,telomere organization	hsa:8290,path:hsa05202,Transcriptional misregulation in cancer;hsa:8290,path:hsa05322,Systemic lupus erythematosus;hsa:8290,path:hsa05034,Alcoholism;hsa:8290,path:hsa05131,Shigellosis;hsa:3020,path:hsa05202,Transcriptional misregulation in cancer;hsa:3020,path:hsa05322,Systemic lupus erythematosus;hsa:3020,path:hsa05034,Alcoholism;hsa:3020,path:hsa05131,Shigellosis;hsa:3021,path:hsa05202,Transcriptional misregulation in cancer;hsa:3021,path:hsa05322,Systemic lupus erythematosus;hsa:3021,path:hsa05034,Alcoholism;hsa:3021,path:hsa05131,Shigellosis;hsa:440093,path:hsa05202,Transcriptional misregulation in cancer;hsa:440093,path:hsa05322,Systemic lupus erythematosus;hsa:440093,path:hsa05034,Alcoholism;hsa:440093,path:hsa05131,Shigellosis
SH3G1_HUMAN	Q99961	SH3GL1	Endophilin-A2	1.314229409	0.282738706	0.669323856	0.667701115	0.7984840575	0.6685124855	0.7984840575	0.6685124855	1.19441906444394	0.375397	0	0.837227092038716	0.375081	0	GO:0042995,cell projection;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0098978,glutamatergic synapse;GO:0098686,hippocampal mossy fiber to CA3 synapse;GO:0002102,podosome;GO:0099092,postsynaptic density, intracellular component;GO:0098793,presynapse;GO:0098685,Schaffer collateral - CA1 synapse	GO:0031697,beta-1 adrenergic receptor binding;GO:0045296,cadherin binding;GO:0051020,GTPase binding;GO:0042802,identical protein binding;GO:0044325,ion channel binding;GO:0008289,lipid binding;GO:0019902,phosphatase binding;GO:0008022,protein C-terminus binding;GO:0017124,SH3 domain binding	GO:0007417,central nervous system development;GO:0098815,modulation of excitatory postsynaptic potential;GO:1900244,positive regulation of synaptic vesicle endocytosis;GO:0007165,signal transduction;GO:0016191,synaptic vesicle uncoating	hsa:6455,path:hsa04144,Endocytosis
SDHB_HUMAN	P21912	SDHB	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	1.437010252	1.35932731	1.783615381	0.988392479	1.398168781	1.38600393	1.398168781	1.38600393	1.0087769238865	0.430456	0	0.991299440264072	0.430253	0	GO:0005743,mitochondrial inner membrane;GO:0031966,mitochondrial membrane;GO:0005749,mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone);GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0051537,2 iron, 2 sulfur cluster binding;GO:0051538,3 iron, 4 sulfur cluster binding;GO:0051539,4 iron, 4 sulfur cluster binding;GO:0009055,electron transfer activity;GO:0046872,metal ion binding;GO:0008177,succinate dehydrogenase (ubiquinone) activity;GO:0048039,ubiquinone binding	GO:0009060,aerobic respiration;GO:0022904,respiratory electron transport chain;GO:0006105,succinate metabolic process;GO:0006099,tricarboxylic acid cycle	hsa:6390,path:hsa00020,Citrate cycle (TCA cycle);hsa:6390,path:hsa00190,Oxidative phosphorylation;hsa:6390,path:hsa04714,Thermogenesis;hsa:6390,path:hsa05010,Alzheimer disease;hsa:6390,path:hsa05012,Parkinson disease;hsa:6390,path:hsa05016,Huntington disease;hsa:6390,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
KV127_HUMAN	A0A075B6S5	IGKV1-27	Immunoglobulin kappa variable 1-27	0.04118362	0.272528217	0.219869812	0.171343663	0.1568559185	0.1956067375	0.1568559185	0.1956067375	0.801894252236583	0.486811	0	1.24704722251204	0.486916	0	GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0072562,blood microparticle;GO:0070062,extracellular exosome	GO:0003823,antigen binding;GO:0042802,identical protein binding	GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
AT2B1_HUMAN	P20020	ATP2B1	Plasma membrane calcium-transporting ATPase 1	0.56228481	0.802930384	1.186164561	2.707303686	0.682607597	1.9467341235	0.682607597	1.9467341235	0.350642436868961	0.097277	0	2.85190808314429	0.097573	0	GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0009898,cytoplasmic side of plasma membrane;GO:0032591,dendritic spine membrane;GO:0070062,extracellular exosome;GO:0098982,GABA-ergic synapse;GO:0098978,glutamatergic synapse;GO:0001772,immunological synapse;GO:0005887,integral component of plasma membrane;GO:0099059,integral component of presynaptic active zone membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0045121,membrane raft;GO:0032809,neuronal cell body membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0016021,integral component of membrane;GO:0016328,lateral plasma membrane	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0019829,ATPase-coupled cation transmembrane transporter activity;GO:0015085,calcium ion transmembrane transporter activity;GO:0005516,calmodulin binding;GO:0046872,metal ion binding;GO:0005388,P-type calcium transporter activity;GO:1905056,P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration;GO:0030165,PDZ domain binding	GO:0007568,aging;GO:0007420,brain development;GO:1990034,calcium ion export across plasma membrane;GO:0006874,cellular calcium ion homeostasis;GO:0071386,cellular response to corticosterone stimulus;GO:0071305,cellular response to vitamin D;GO:0034220,ion transmembrane transport;GO:0001818,negative regulation of cytokine production;GO:0051481,negative regulation of cytosolic calcium ion concentration;GO:0003407,neural retina development;GO:0030501,positive regulation of bone mineralization;GO:0051928,positive regulation of calcium ion transport;GO:0008217,regulation of blood pressure;GO:1903779,regulation of cardiac conduction;GO:1900076,regulation of cellular response to insulin stimulus;GO:0051480,regulation of cytosolic calcium ion concentration;GO:0003056,regulation of vascular associated smooth muscle contraction;GO:0009409,response to cold	hsa:490,path:hsa04020,Calcium signaling pathway;hsa:490,path:hsa04024,cAMP signaling pathway;hsa:490,path:hsa04022,cGMP-PKG signaling pathway;hsa:490,path:hsa04925,Aldosterone synthesis and secretion;hsa:490,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:490,path:hsa04970,Salivary secretion;hsa:490,path:hsa04972,Pancreatic secretion;hsa:490,path:hsa04978,Mineral absorption;hsa:490,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption
SPT5H_HUMAN	O00267	SUPT5H	Transcription elongation factor SPT5	0.120284926	0.068821414	0.7509584	0.022162719	0.09455317	0.3865605595	0.09455317	0.3865605595	0.244601182599437	0.032331	-1	4.08828767454333	0.032501	1	GO:0032044,DSIF complex;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003682,chromatin binding;GO:0019899,enzyme binding;GO:0003729,mRNA binding;GO:0046982,protein heterodimerization activity;GO:0003723,RNA binding	GO:0006370,7-methylguanosine mRNA capping;GO:0032785,negative regulation of DNA-templated transcription, elongation;GO:1900364,negative regulation of mRNA polyadenylation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0032786,positive regulation of DNA-templated transcription, elongation;GO:0016239,positive regulation of macroautophagy;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0050434,positive regulation of viral transcription;GO:0006357,regulation of transcription by RNA polymerase II;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter;GO:0032784,regulation of DNA-templated transcription, elongation	
PRP16_HUMAN	Q92620	DHX38	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16	0.076378572	0.064223124	0.184726932	0.101480038	0.070300848	0.143103485	0.070300848	0.143103485	0.491258811761293	0.217136	0	2.0355868964767	0.217467	0	GO:0071013,catalytic step 2 spliceosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex	GO:0005524,ATP binding;GO:0016787,hydrolase activity;GO:0003723,RNA binding;GO:0003724,RNA helicase activity	GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0006405,RNA export from nucleus	hsa:9785,path:hsa03040,Spliceosome
GNPI1_HUMAN	P46926	GNPDA1	Glucosamine-6-phosphate isomerase 1	2.435240905	2.631455601	3.623480553	1.850074839	2.533348253	2.736777696	2.533348253	2.736777696	0.925668261876978	0.459082	0	1.08030062300321	0.458941	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0004342,glucosamine-6-phosphate deaminase activity;GO:0042802,identical protein binding	GO:0005975,carbohydrate metabolic process;GO:0006091,generation of precursor metabolites and energy;GO:0006043,glucosamine catabolic process;GO:0006046,N-acetylglucosamine catabolic process;GO:0019262,N-acetylneuraminate catabolic process;GO:0007338,single fertilization;GO:0006048,UDP-N-acetylglucosamine biosynthetic process;GO:0006044,N-acetylglucosamine metabolic process	hsa:10007,path:hsa00520,Amino sugar and nucleotide sugar metabolism
MAOM_HUMAN	P23368	ME2	NAD-dependent malic enzyme, mitochondrial	4.954958609	2.273599713	4.600058301	3.434843567	3.614279161	4.017450934	3.614279161	4.017450934	0.899644879396553	0.468631	0	1.11154970466876	0.468511	0	GO:0043231,intracellular membrane-bounded organelle;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0009055,electron transfer activity;GO:0004471,malate dehydrogenase (decarboxylating) (NAD+) activity;GO:0004473,malate dehydrogenase (decarboxylating) (NADP+) activity;GO:0004470,malic enzyme activity;GO:0046872,metal ion binding;GO:0051287,NAD binding;GO:0008948,oxaloacetate decarboxylase activity	GO:0006108,malate metabolic process;GO:0006090,pyruvate metabolic process;GO:1902031,regulation of NADP metabolic process;GO:0006099,tricarboxylic acid cycle	hsa:4200,path:hsa00620,Pyruvate metabolism
NDKA_HUMAN	P15531	NME1	Nucleoside diphosphate kinase A	46.18903847	126.8474258	5.059024356	1.58951957	86.518232135	3.324271963	86.518232135	3.324271963	26.0262196047646	0.001779	1	0.0384227911385536	0.001742	-1	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005882,intermediate filament;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0032587,ruffle membrane	GO:0005524,ATP binding;GO:0004536,deoxyribonuclease activity;GO:0019899,enzyme binding;GO:0043015,gamma-tubulin binding;GO:0005525,GTP binding;GO:0042802,identical protein binding;GO:0019215,intermediate filament binding;GO:0000287,magnesium ion binding;GO:0004550,nucleoside diphosphate kinase activity;GO:0043024,ribosomal small subunit binding;GO:0003723,RNA binding;GO:0000977,RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0003697,single-stranded DNA binding	GO:0030154,cell differentiation;GO:0035690,cellular response to drug;GO:0071398,cellular response to fatty acid;GO:0071333,cellular response to glucose stimulus;GO:0006241,CTP biosynthetic process;GO:0006897,endocytosis;GO:0006183,GTP biosynthetic process;GO:0021766,hippocampus development;GO:0007595,lactation;GO:0008285,negative regulation of cell population proliferation;GO:0010629,negative regulation of gene expression;GO:0002762,negative regulation of myeloid leukocyte differentiation;GO:0015949,nucleobase-containing small molecule interconversion;GO:0043388,positive regulation of DNA binding;GO:0050679,positive regulation of epithelial cell proliferation;GO:0010976,positive regulation of neuron projection development;GO:0042981,regulation of apoptotic process;GO:0014075,response to amine;GO:0051591,response to cAMP;GO:0033574,response to testosterone;GO:0006228,UTP biosynthetic process	hsa:4830,path:hsa00230,Purine metabolism;hsa:4830,path:hsa00240,Pyrimidine metabolism;hsa:4830,path:hsa00983,Drug metabolism - other enzymes
LAMP3_HUMAN	Q9UQV4	LAMP3	Lysosome-associated membrane glycoprotein 3	2.55E-05	0.026191072	0.679756958	1.119503973	0.013108286	0.8996304655	0.013108286	0.8996304655	0.0145707448810269	0.000000	-1	68.6306711266446	0.000000	1	GO:0097233,alveolar lamellar body membrane;GO:0005769,early endosome;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0031982,vesicle		GO:0002250,adaptive immune response;GO:0072594,establishment of protein localization to organelle;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:1901799,negative regulation of proteasomal protein catabolic process;GO:0010628,positive regulation of gene expression;GO:0010506,regulation of autophagy;GO:1903900,regulation of viral life cycle;GO:0035455,response to interferon-alpha	hsa:27074,path:hsa04142,Lysosome
DDX6_HUMAN	P26196	DDX6	Probable ATP-dependent RNA helicase DDX6	9.734523093	13.37621187	14.09686753	134.9607652	11.5553674815	74.528816365	11.5553674815	74.528816365	0.155045632616897	0.005475	-1	6.44971408173039	0.005524	1	GO:0005912,adherens junction;GO:0033391,chromatoid body;GO:0061830,concave side of sperm head;GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0000792,heterochromatin;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005634,nucleus;GO:0001520,outer dense fiber;GO:0000932,P-body;GO:0048471,perinuclear region of cytoplasm;GO:0016442,RISC complex;GO:0097227,sperm annulus	GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0004386,helicase activity;GO:0003729,mRNA binding;GO:0019904,protein domain specific binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0016787,hydrolase activity;GO:0003676,nucleic acid binding	GO:0043928,exonucleolytic catabolism of deadenylated mRNA;GO:0045665,negative regulation of neuron differentiation;GO:0017148,negative regulation of translation;GO:0033962,P-body assembly;GO:1905618,positive regulation of miRNA mediated inhibition of translation;GO:0048515,spermatid differentiation;GO:0019827,stem cell population maintenance;GO:0034063,stress granule assembly;GO:0019074,viral RNA genome packaging	hsa:1656,path:hsa03018,RNA degradation
PGM2L_HUMAN	Q6PCE3	PGM2L1	Glucose 1,6-bisphosphate synthase	0.311894485	0.417101451	0.350501329	0.40703606	0.364497968	0.3787686945	0.364497968	0.3787686945	0.96232337385	0.446117	0	1.03915173129305	0.445947	0	GO:0005829,cytosol	GO:0047933,glucose-1,6-bisphosphate synthase activity;GO:0016868,intramolecular transferase activity, phosphotransferases;GO:0046872,metal ion binding	GO:0019388,galactose catabolic process;GO:0051156,glucose 6-phosphate metabolic process;GO:0006006,glucose metabolic process;GO:0005978,glycogen biosynthetic process;GO:0005980,glycogen catabolic process	hsa:283209,path:hsa00500,Starch and sucrose metabolism
ECP_HUMAN	P12724	RNASE3	Eosinophil cationic protein	0.700080009	30.38331622	0.331730355	0.167544911	15.5416981145	0.249637633	15.5416981145	0.249637633	62.2570320337078	0.000131	1	0.0160624425439775	0.000127	-1	GO:0035578,azurophil granule lumen;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0004519,endonuclease activity;GO:0001530,lipopolysaccharide binding;GO:0003676,nucleic acid binding;GO:0004540,ribonuclease activity	GO:0019731,antibacterial humoral response;GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0019730,antimicrobial humoral response;GO:0006935,chemotaxis;GO:0050829,defense response to Gram-negative bacterium;GO:0050830,defense response to Gram-positive bacterium;GO:0043152,induction of bacterial agglutination;GO:0045087,innate immune response;GO:0002227,innate immune response in mucosa;GO:0043312,neutrophil degranulation;GO:0006401,RNA catabolic process	hsa:6037,path:hsa05310,Asthma
GBB4_HUMAN	Q9HAV0	GNB4	Guanine nucleotide-binding protein subunit beta-4	0.154840445	2.55E-05	2.55E-05	0.389860497	0.0774329725	0.1949429985	0.0774329725	0.1949429985	0.397208276756859	0.134220	0	2.51757090301551	0.134544	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005834,heterotrimeric G-protein complex;GO:0005765,lysosomal membrane	GO:0031682,G-protein gamma-subunit binding;GO:0044877,protein-containing complex binding	GO:0007186,G protein-coupled receptor signaling pathway;GO:0006457,protein folding;GO:0021762,substantia nigra development;GO:0007165,signal transduction	hsa:59345,path:hsa04014,Ras signaling pathway;hsa:59345,path:hsa04371,Apelin signaling pathway;hsa:59345,path:hsa04151,PI3K-Akt signaling pathway;hsa:59345,path:hsa04062,Chemokine signaling pathway;hsa:59345,path:hsa04926,Relaxin signaling pathway;hsa:59345,path:hsa04724,Glutamatergic synapse;hsa:59345,path:hsa04727,GABAergic synapse;hsa:59345,path:hsa04725,Cholinergic synapse;hsa:59345,path:hsa04728,Dopaminergic synapse;hsa:59345,path:hsa04726,Serotonergic synapse;hsa:59345,path:hsa04723,Retrograde endocannabinoid signaling;hsa:59345,path:hsa04713,Circadian entrainment;hsa:59345,path:hsa05200,Pathways in cancer;hsa:59345,path:hsa05032,Morphine addiction;hsa:59345,path:hsa05034,Alcoholism;hsa:59345,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:59345,path:hsa05163,Human cytomegalovirus infection;hsa:59345,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection
PXL2A_HUMAN	Q9BRX8	PRXL2A	Peroxiredoxin-like 2A	1.338068285	1.306636278	0.27883207	0.098742659	1.3223522815	0.1887873645	1.3223522815	0.1887873645	7.00445331710746	0.035263	1	0.14276631661712	0.034940	-1	GO:0005737,cytoplasm;GO:0005576,extracellular region	GO:0016209,antioxidant activity	GO:0045670,regulation of osteoclast differentiation	
TRUA_HUMAN	Q9Y606	PUS1	tRNA pseudouridine synthase A	0.16436071	0.23069825	0.247416038	0.583735898	0.19752948	0.415575968	0.19752948	0.415575968	0.475314972977456	0.202614	0	2.10386808085558	0.202948	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0009982,pseudouridine synthase activity;GO:0003723,RNA binding;GO:0002153,steroid receptor RNA activator RNA binding;GO:0000049,tRNA binding;GO:0106029,tRNA pseudouridine synthase activity	GO:0070902,mitochondrial tRNA pseudouridine synthesis;GO:1990481,mRNA pseudouridine synthesis;GO:0031119,tRNA pseudouridine synthesis;GO:0001522,pseudouridine synthesis	
STAT3_HUMAN	P40763	STAT3	Signal transducer and activator of transcription 3	2.566307048	2.788837388	3.862349125	4.189491399	2.677572218	4.025920262	2.677572218	4.025920262	0.665083271338771	0.374885	0	1.50357112123278	0.375110	0	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0090575,RNA polymerase II transcription regulator complex;GO:0005667,transcription regulator complex	GO:0031490,chromatin DNA binding;GO:0003677,DNA binding;GO:0001228,DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700,DNA-binding transcription factor activity;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0042802,identical protein binding;GO:0004879,nuclear receptor activity;GO:0070878,primary miRNA binding;GO:0046983,protein dimerization activity;GO:0042803,protein homodimerization activity;GO:0019901,protein kinase binding;GO:0019903,protein phosphatase binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001103,RNA polymerase II repressing transcription factor binding;GO:0008134,transcription factor binding;GO:0000976,transcription regulatory region sequence-specific DNA binding	GO:0048708,astrocyte differentiation;GO:0071345,cellular response to cytokine stimulus;GO:0032870,cellular response to hormone stimulus;GO:0044320,cellular response to leptin stimulus;GO:0019221,cytokine-mediated signaling pathway;GO:0006952,defense response;GO:0042755,eating behavior;GO:0097009,energy homeostasis;GO:0001754,eye photoreceptor cell differentiation;GO:0042593,glucose homeostasis;GO:0060396,growth hormone receptor signaling pathway;GO:0060397,growth hormone receptor signaling pathway via JAK-STAT;GO:0006954,inflammatory response;GO:0035723,interleukin-15-mediated signaling pathway;GO:0038114,interleukin-21-mediated signaling pathway;GO:0038155,interleukin-23-mediated signaling pathway;GO:0070106,interleukin-27-mediated signaling pathway;GO:0070757,interleukin-35-mediated signaling pathway;GO:0070102,interleukin-6-mediated signaling pathway;GO:0038111,interleukin-7-mediated signaling pathway;GO:0038113,interleukin-9-mediated signaling pathway;GO:0030522,intracellular receptor signaling pathway;GO:0033210,leptin-mediated signaling pathway;GO:0010507,negative regulation of autophagy;GO:2000635,negative regulation of primary miRNA processing;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0007399,nervous system development;GO:0016310,phosphorylation;GO:0030335,positive regulation of cell migration;GO:1900017,positive regulation of cytokine production involved in inflammatory response;GO:0045648,positive regulation of erythrocyte differentiation;GO:0010628,positive regulation of gene expression;GO:2000637,positive regulation of gene silencing by miRNA;GO:0032731,positive regulation of interleukin-1 beta production;GO:0032733,positive regulation of interleukin-10 production;GO:0032755,positive regulation of interleukin-6 production;GO:0032757,positive regulation of interleukin-8 production;GO:1904685,positive regulation of metalloendopeptidase activity;GO:1905618,positive regulation of miRNA mediated inhibition of translation;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0045747,positive regulation of Notch signaling pathway;GO:1902895,positive regulation of pri-miRNA transcription by RNA polymerase II;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0032760,positive regulation of tumor necrosis factor production;GO:0042531,positive regulation of tyrosine phosphorylation of STAT protein;GO:0006606,protein import into nucleus;GO:0060019,radial glial cell differentiation;GO:0007259,receptor signaling pathway via JAK-STAT;GO:0051726,regulation of cell cycle;GO:0042127,regulation of cell population proliferation;GO:0060259,regulation of feeding behavior;GO:0006357,regulation of transcription by RNA polymerase II;GO:0006355,regulation of transcription, DNA-templated;GO:0032355,response to estradiol;GO:0044321,response to leptin;GO:0043434,response to peptide hormone;GO:0019953,sexual reproduction;GO:0007165,signal transduction;GO:0035019,somatic stem cell population maintenance;GO:0072540,T-helper 17 cell lineage commitment;GO:0072538,T-helper 17 type immune response;GO:0001659,temperature homeostasis;GO:0016032,viral process	hsa:6774,path:hsa04630,Jak-STAT signaling pathway;hsa:6774,path:hsa04066,HIF-1 signaling pathway;hsa:6774,path:hsa04068,FoxO signaling pathway;hsa:6774,path:hsa04217,Necroptosis;hsa:6774,path:hsa04550,Signaling pathways regulating pluripotency of stem cells;hsa:6774,path:hsa04659,Th17 cell differentiation;hsa:6774,path:hsa04062,Chemokine signaling pathway;hsa:6774,path:hsa04920,Adipocytokine signaling pathway;hsa:6774,path:hsa04917,Prolactin signaling pathway;hsa:6774,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:6774,path:hsa05200,Pathways in cancer;hsa:6774,path:hsa05206,MicroRNAs in cancer;hsa:6774,path:hsa05205,Proteoglycans in cancer;hsa:6774,path:hsa05203,Viral carcinogenesis;hsa:6774,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:6774,path:hsa05212,Pancreatic cancer;hsa:6774,path:hsa05221,Acute myeloid leukemia;hsa:6774,path:hsa05223,Non-small cell lung cancer;hsa:6774,path:hsa05321,Inflammatory bowel disease (IBD);hsa:6774,path:hsa04931,Insulin resistance;hsa:6774,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:6774,path:hsa05162,Measles;hsa:6774,path:hsa05161,Hepatitis B;hsa:6774,path:hsa05160,Hepatitis C;hsa:6774,path:hsa05163,Human cytomegalovirus infection;hsa:6774,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:6774,path:hsa05169,Epstein-Barr virus infection;hsa:6774,path:hsa05145,Toxoplasmosis;hsa:6774,path:hsa01521,EGFR tyrosine kinase inhibitor resistance
TMM11_HUMAN	P17152	TMEM11	Transmembrane protein 11, mitochondrial	0.198635269	0.193097163	0.02749725	2.55E-05	0.195866216	0.013761375	0.195866216	0.013761375	14.2330411023608	0.008061	1	0.0702590537614716	0.007941	-1	GO:0031305,integral component of mitochondrial inner membrane;GO:0005887,integral component of plasma membrane;GO:0005739,mitochondrion		GO:0007007,inner mitochondrial membrane organization;GO:0007005,mitochondrion organization	
DHRS7_HUMAN	Q9Y394	DHRS7	Dehydrogenase/reductase SDR family member 7	1.95056749	2.774049247	3.829736945	2.195105388	2.3623083685	3.0124211665	2.3623083685	3.0124211665	0.784189274318724	0.473217	0	1.27520234304246	0.473338	0	GO:0016020,membrane	GO:0016491,oxidoreductase activity		
SAFB1_HUMAN	Q15424	SAFB	Scaffold attachment factor B1	0.095073817	0.045997949	0.129197878	2.55E-05	0.070535883	0.064611689	0.070535883	0.064611689	1.09168919883831	0.404472	0	0.916011627727124	0.404214	0	GO:0030496,midbody;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003682,chromatin binding;GO:0003690,double-stranded DNA binding;GO:0003723,RNA binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565,sequence-specific DNA binding	GO:0006325,chromatin organization;GO:0030520,intracellular estrogen receptor signaling pathway;GO:0050684,regulation of mRNA processing;GO:0006357,regulation of transcription by RNA polymerase II;GO:0006355,regulation of transcription, DNA-templated	
UN45A_HUMAN	Q9H3U1	UNC45A	Protein unc-45 homolog A	0.832001485	0.373902253	1.187868934	0.945248903	0.602951869	1.0665589185	0.602951869	1.0665589185	0.565324482821809	0.285257	0	1.7688956172719	0.285555	0	GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0016607,nuclear speck;GO:0048471,perinuclear region of cytoplasm	GO:0045296,cadherin binding;GO:0051879,Hsp90 protein binding	GO:0030154,cell differentiation;GO:0061077,chaperone-mediated protein folding;GO:0007517,muscle organ development	
SMC1A_HUMAN	Q14683	SMC1A	Structural maintenance of chromosomes protein 1A	1.863218776	1.621507483	2.026950977	2.930121902	1.7423631295	2.4785364395	1.7423631295	2.4785364395	0.702980638788385	0.407394	0	1.42251428392614	0.407587	0	GO:0005694,chromosome;GO:0000775,chromosome, centromeric region;GO:0008278,cohesin complex;GO:0000777,condensed chromosome kinetochore;GO:0000794,condensed nuclear chromosome;GO:0005829,cytosol;GO:0000776,kinetochore;GO:0030893,meiotic cohesin complex;GO:0097431,mitotic spindle pole;GO:0016363,nuclear matrix;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0003682,chromatin binding;GO:0003677,DNA binding;GO:0036033,mediator complex binding;GO:0046982,protein heterodimerization activity;GO:0003723,RNA binding	GO:0051301,cell division;GO:0006281,DNA repair;GO:0051321,meiotic cell cycle;GO:0007064,mitotic sister chromatid cohesion;GO:0000070,mitotic sister chromatid segregation;GO:0090307,mitotic spindle assembly;GO:0072423,response to DNA damage checkpoint signaling;GO:0009314,response to radiation;GO:0007062,sister chromatid cohesion;GO:0019827,stem cell population maintenance	hsa:8243,path:hsa04110,Cell cycle;hsa:8243,path:hsa04114,Oocyte meiosis
MAP4_HUMAN	P27816	MAP4	Microtubule-associated protein 4	0.964448401	2.807056604	0.858438237	1.168413762	1.8857525025	1.0134259995	1.8857525025	1.0134259995	1.86076980798833	0.244702	0	0.537411987074905	0.244177	0	GO:0030424,axon;GO:0005930,axoneme;GO:0005829,cytosol;GO:0005874,microtubule;GO:0005875,microtubule associated complex;GO:0015630,microtubule cytoskeleton;GO:0072686,mitotic spindle;GO:0043005,neuron projection;GO:0005886,plasma membrane;GO:0005737,cytoplasm	GO:0008017,microtubule binding;GO:0003723,RNA binding;GO:0005198,structural molecule activity	GO:0051301,cell division;GO:0051294,establishment of spindle orientation;GO:0000226,microtubule cytoskeleton organization;GO:0051012,microtubule sliding;GO:0007052,mitotic spindle organization;GO:1902856,negative regulation of non-motile cilium assembly;GO:0031175,neuron projection development	
MMS19_HUMAN	Q96T76	MMS19	MMS19 nucleotide excision repair protein homolog	0.196334118	0.096330673	0.282788562	0.109238424	0.1463323955	0.196013493	0.1463323955	0.196013493	0.746542461237605	0.443393	0	1.33950853691861	0.443548	0	GO:0097361,CIA complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005815,microtubule organizing center;GO:0071817,MMXD complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005819,spindle;GO:0005675,transcription factor TFIIH holo complex	GO:0019899,enzyme binding;GO:0030331,estrogen receptor binding;GO:0030674,protein-macromolecule adaptor activity;GO:0030159,signaling receptor complex adaptor activity;GO:0003713,transcription coactivator activity	GO:0006974,cellular response to DNA damage stimulus;GO:0007059,chromosome segregation;GO:0006259,DNA metabolic process;GO:0006281,DNA repair;GO:0016226,iron-sulfur cluster assembly;GO:0006289,nucleotide-excision repair;GO:0000160,phosphorelay signal transduction system;GO:1905168,positive regulation of double-strand break repair via homologous recombination;GO:0045893,positive regulation of transcription, DNA-templated;GO:0097428,protein maturation by iron-sulfur cluster transfer;GO:0009725,response to hormone;GO:0006351,transcription, DNA-templated	
AL1A3_HUMAN	P47895	ALDH1A3	Aldehyde dehydrogenase family 1 member A3	0.035976913	0.098902337	0.202126338	0.244185135	0.067439625	0.2231557365	0.067439625	0.2231557365	0.302208789510549	0.063706	0	3.30897060148244	0.063953	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0004029,aldehyde dehydrogenase (NAD+) activity;GO:0004030,aldehyde dehydrogenase [NAD(P)+] activity;GO:0070403,NAD+ binding;GO:0042803,protein homodimerization activity;GO:0001758,retinal dehydrogenase activity;GO:0070324,thyroid hormone binding;GO:0016620,oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0016491,oxidoreductase activity	GO:0031076,embryonic camera-type eye development;GO:0048048,embryonic eye morphogenesis;GO:0060324,face development;GO:0070384,Harderian gland development;GO:0042472,inner ear morphogenesis;GO:0007626,locomotory behavior;GO:0050885,neuromuscular process controlling balance;GO:0021768,nucleus accumbens development;GO:0060166,olfactory pit development;GO:0002072,optic cup morphogenesis involved in camera-type eye development;GO:0043065,positive regulation of apoptotic process;GO:0051289,protein homotetramerization;GO:0042574,retinal metabolic process;GO:0002138,retinoic acid biosynthetic process;GO:0042573,retinoic acid metabolic process;GO:0042572,retinol metabolic process;GO:0060013,righting reflex	hsa:220,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:220,path:hsa00340,Histidine metabolism;hsa:220,path:hsa00350,Tyrosine metabolism;hsa:220,path:hsa00360,Phenylalanine metabolism;hsa:220,path:hsa00410,beta-Alanine metabolism;hsa:220,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:220,path:hsa00982,Drug metabolism - cytochrome P450;hsa:220,path:hsa05204,Chemical carcinogenesis
AKA12_HUMAN	Q02952	AKAP12	A-kinase anchor protein 12	0.054504998	0.023322082	0.018076687	0.285542048	0.03891354	0.1518093675	0.03891354	0.1518093675	0.256331612737929	0.037866	-1	3.90119653724642	0.038053	1	GO:0005938,cell cortex;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0043025,neuronal cell body;GO:0005886,plasma membrane;GO:0098685,Schaffer collateral - CA1 synapse	GO:0008179,adenylate cyclase binding;GO:0005516,calmodulin binding;GO:0051018,protein kinase A binding	GO:0007193,adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0071347,cellular response to interleukin-1;GO:0071356,cellular response to tumor necrosis factor;GO:0007186,G protein-coupled receptor signaling pathway;GO:0035733,hepatic stellate cell activation;GO:0050804,modulation of chemical synaptic transmission;GO:0043116,negative regulation of vascular permeability;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0061870,positive regulation of hepatic stellate cell migration;GO:0051770,positive regulation of nitric-oxide synthase biosynthetic process;GO:1900143,positive regulation of oligodendrocyte apoptotic process;GO:0010739,positive regulation of protein kinase A signaling;GO:0032760,positive regulation of tumor necrosis factor production;GO:0010738,regulation of protein kinase A signaling;GO:0090036,regulation of protein kinase C signaling;GO:0051602,response to electrical stimulus;GO:0032496,response to lipopolysaccharide	
DOCK8_HUMAN	Q8NF50	DOCK8	Dedicator of cytokinesis protein 8	0.170540373	0.088138365	0.453661971	0.366279314	0.129339369	0.4099706425	0.129339369	0.4099706425	0.315484465451694	0.072325	0	3.16972817843266	0.072588	0	GO:0005737,cytoplasm;GO:0031258,lamellipodium membrane;GO:0031256,leading edge membrane;GO:0016020,membrane	GO:0005085,guanyl-nucleotide exchange factor activity	GO:1990869,cellular response to chemokine;GO:0036336,dendritic cell migration;GO:0001771,immunological synapse formation;GO:0061485,memory T cell proliferation;GO:0070233,negative regulation of T cell apoptotic process;GO:1903905,positive regulation of establishment of T cell polarity;GO:0043547,positive regulation of GTPase activity;GO:2000406,positive regulation of T cell migration;GO:0007264,small GTPase mediated signal transduction	
RL12_HUMAN	P30050	RPL12	60S ribosomal protein L12	19.65587637	30.99323547	12.91544235	20.79263939	25.32455592	16.85404087	25.32455592	16.85404087	1.50258066390936	0.304658	0	0.665521674821929	0.304215	0	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0015934,large ribosomal subunit;GO:0016020,membrane;GO:0014069,postsynaptic density	GO:0070180,large ribosomal subunit rRNA binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6136,path:hsa03010,Ribosome
ZCCHV_HUMAN	Q7Z2W4	ZC3HAV1	Zinc finger CCCH-type antiviral protein 1	1.227163606	0.479966057	0.407690917	0.042502925	0.8535648315	0.225096921	0.8535648315	0.225096921	3.7919880365667	0.098301	0	0.263713912163449	0.097781	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus	GO:0045296,cadherin binding;GO:0046872,metal ion binding;GO:0003723,RNA binding;GO:0003950,NAD+ ADP-ribosyltransferase activity	GO:0051607,defense response to virus;GO:0045087,innate immune response;GO:0045071,negative regulation of viral genome replication;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0032727,positive regulation of interferon-alpha production;GO:0032728,positive regulation of interferon-beta production;GO:0061014,positive regulation of mRNA catabolic process;GO:1900246,positive regulation of RIG-I signaling pathway;GO:0006471,protein ADP-ribosylation;GO:0009615,response to virus	
NXF1_HUMAN	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.179139622	0.115212029	0.291179146	1.073458291	0.1471758255	0.6823187185	0.1471758255	0.6823187185	0.215699527961873	0.020687	-1	4.63607875941555	0.020816	1	GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0042405,nuclear inclusion body;GO:0005643,nuclear pore;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0006406,mRNA export from nucleus;GO:0016973,poly(A)+ mRNA export from nucleus;GO:0006405,RNA export from nucleus;GO:0016032,viral process;GO:0051028,mRNA transport	hsa:10482,path:hsa03013,RNA transport;hsa:10482,path:hsa03015,mRNA surveillance pathway;hsa:10482,path:hsa03008,Ribosome biogenesis in eukaryotes;hsa:10482,path:hsa05164,Influenza A;hsa:10482,path:hsa05168,Herpes simplex virus 1 infection
FHL2_HUMAN	Q14192	FHL2	Four and a half LIM domains protein 2	1.251637251	0.820229608	0.281152147	4.116906908	1.0359334295	2.1990295275	1.0359334295	2.1990295275	0.471086639149278	0.198783	0	2.12275177620378	0.199117	0	GO:0005925,focal adhesion;GO:0031430,M band;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0030018,Z disc	GO:0043425,bHLH transcription factor binding;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0003712,transcription coregulator activity;GO:0003714,transcription corepressor activity;GO:0008134,transcription factor binding	GO:0055014,atrial cardiac muscle cell development;GO:0060347,heart trabecula formation;GO:0043066,negative regulation of apoptotic process;GO:0070885,negative regulation of calcineurin-NFAT signaling cascade;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0001649,osteoblast differentiation;GO:0019222,regulation of metabolic process;GO:0009725,response to hormone;GO:0055015,ventricular cardiac muscle cell development	hsa:2274,path:hsa04380,Osteoclast differentiation
HACD3_HUMAN	Q9P035	HACD3	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3	1.855565297	1.613568299	3.549909784	1.977966477	1.734566798	2.7639381305	1.734566798	2.7639381305	0.627570776226534	0.341760	0	1.59344577198577	0.342016	0	GO:0005783,endoplasmic reticulum;GO:0005925,focal adhesion;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0031965,nuclear membrane;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane	GO:0102343,3-hydroxy-arachidoyl-CoA dehydratase activity;GO:0102344,3-hydroxy-behenoyl-CoA dehydratase activity;GO:0102345,3-hydroxy-lignoceroyl-CoA dehydratase activity;GO:0018812,3-hydroxyacyl-CoA dehydratase activity;GO:0019899,enzyme binding;GO:0005096,GTPase activator activity;GO:0102158,very-long-chain 3-hydroxyacyl-CoA dehydratase activity	GO:0007257,activation of JUN kinase activity;GO:0030497,fatty acid elongation;GO:0007249,I-kappaB kinase/NF-kappaB signaling;GO:0046726,positive regulation by virus of viral protein levels in host cell;GO:0045070,positive regulation of viral genome replication;GO:0016601,Rac protein signal transduction;GO:0007264,small GTPase mediated signal transduction;GO:0030148,sphingolipid biosynthetic process;GO:0042761,very long-chain fatty acid biosynthetic process;GO:0006633,fatty acid biosynthetic process;GO:0007254,JNK cascade;GO:0007266,Rho protein signal transduction	hsa:51495,path:hsa00062,Fatty acid elongation;hsa:51495,path:hsa01040,Biosynthesis of unsaturated fatty acids
CO6_HUMAN	P13671	C6	Complement component C6	0.069434619	0.032678164	0.099890773	0.400522583	0.0510563915	0.250206678	0.0510563915	0.250206678	0.204056869737106	0.016812	-1	4.90059462976345	0.016924	1	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005579,membrane attack complex		GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0019835,cytolysis;GO:0001701,in utero embryonic development;GO:0045087,innate immune response;GO:0030449,regulation of complement activation	hsa:729,path:hsa04610,Complement and coagulation cascades;hsa:729,path:hsa05322,Systemic lupus erythematosus;hsa:729,path:hsa05020,Prion diseases
PYGB_HUMAN	P11216	PYGB	Glycogen phosphorylase, brain form	3.306525	4.881120034	6.159769491	8.954097984	4.093822517	7.5569337375	4.093822517	7.5569337375	0.541730635626074	0.263548	0	1.84593584751637	0.263860	0	GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0016020,membrane	GO:0008184,glycogen phosphorylase activity;GO:0102250,linear malto-oligosaccharide phosphorylase activity;GO:0030170,pyridoxal phosphate binding;GO:0102499,SHG alpha-glucan phosphorylase activity	GO:0005980,glycogen catabolic process;GO:0043312,neutrophil degranulation;GO:0005975,carbohydrate metabolic process	hsa:5834,path:hsa00500,Starch and sucrose metabolism;hsa:5834,path:hsa04217,Necroptosis;hsa:5834,path:hsa04910,Insulin signaling pathway;hsa:5834,path:hsa04922,Glucagon signaling pathway;hsa:5834,path:hsa04931,Insulin resistance
FUBP1_HUMAN	Q96AE4	FUBP1	Far upstream element-binding protein 1	4.877928194	3.701360215	5.932032293	6.799808134	4.2896442045	6.3659202135	4.2896442045	6.3659202135	0.673845109683136	0.382493	0	1.48402056441462	0.382710	0	GO:0005737,cytoplasm;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0003697,single-stranded DNA binding	GO:0010628,positive regulation of gene expression;GO:0010468,regulation of gene expression;GO:0006355,regulation of transcription, DNA-templated	
NDUS8_HUMAN	O00217	NDUFS8	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	0.597728429	1.039985001	0.150592228	0.014842093	0.818856715	0.0827171605	0.818856715	0.0827171605	9.89947805328738	0.017860	1	0.101015426734334	0.017649	-1	GO:0005759,mitochondrial matrix;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion;GO:0070469,respirasome;GO:0016020,membrane	GO:0051539,4 iron, 4 sulfur cluster binding;GO:0046872,metal ion binding;GO:0008137,NADH dehydrogenase (ubiquinone) activity;GO:0016651,oxidoreductase activity, acting on NAD(P)H	GO:0009060,aerobic respiration;GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0006979,response to oxidative stress	hsa:4728,path:hsa00190,Oxidative phosphorylation;hsa:4728,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4728,path:hsa04714,Thermogenesis;hsa:4728,path:hsa05010,Alzheimer disease;hsa:4728,path:hsa05012,Parkinson disease;hsa:4728,path:hsa05016,Huntington disease;hsa:4728,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
DLG1_HUMAN	Q12959	DLG1	Disks large homolog 1	0.334253952	0.147808792	0.283290457	0.542655819	0.241031372	0.412973138	0.241031372	0.412973138	0.583649031429255	0.302039	0	1.71335845028505	0.302326	0	GO:0016324,apical plasma membrane;GO:0005604,basement membrane;GO:0016323,basolateral plasma membrane;GO:0005923,bicellular tight junction;GO:0030054,cell junction;GO:0031253,cell projection membrane;GO:0005911,cell-cell junction;GO:0005737,cytoplasm;GO:0009898,cytoplasmic side of plasma membrane;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0005794,Golgi apparatus;GO:0001772,immunological synapse;GO:0014704,intercalated disc;GO:0043219,lateral loop;GO:0016328,lateral plasma membrane;GO:0045121,membrane raft;GO:0005874,microtubule;GO:0097025,MPP7-DLG1-LIN7 complex;GO:0035748,myelin sheath abaxonal region;GO:0031594,neuromuscular junction;GO:0043005,neuron projection;GO:0033268,node of Ranvier;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0098839,postsynaptic density membrane;GO:0042383,sarcolemma;GO:0097060,synaptic membrane;GO:0016020,membrane	GO:0045296,cadherin binding;GO:0008092,cytoskeletal protein binding;GO:0004385,guanylate kinase activity;GO:0044325,ion channel binding;GO:0097016,L27 domain binding;GO:0031434,mitogen-activated protein kinase kinase binding;GO:0060090,molecular adaptor activity;GO:0019902,phosphatase binding;GO:0004721,phosphoprotein phosphatase activity;GO:0015459,potassium channel regulator activity;GO:0008022,protein C-terminus binding;GO:0019901,protein kinase binding;GO:0098919,structural constituent of postsynaptic density	GO:0007015,actin filament organization;GO:0032147,activation of protein kinase activity;GO:0042982,amyloid precursor protein metabolic process;GO:0030953,astral microtubule organization;GO:0070830,bicellular tight junction assembly;GO:0001658,branching involved in ureteric bud morphogenesis;GO:0098609,cell-cell adhesion;GO:0034629,cellular protein-containing complex localization;GO:0007268,chemical synaptic transmission;GO:0030866,cortical actin cytoskeleton organization;GO:0043622,cortical microtubule organization;GO:0048704,embryonic skeletal system morphogenesis;GO:0001935,endothelial cell proliferation;GO:0051660,establishment of centrosome localization;GO:0007163,establishment or maintenance of cell polarity;GO:0045197,establishment or maintenance of epithelial cell apical/basal polarity;GO:0060022,hard palate development;GO:0001771,immunological synapse formation;GO:0002088,lens development in camera-type eye;GO:0000165,MAPK cascade;GO:0031579,membrane raft organization;GO:0050680,negative regulation of epithelial cell proliferation;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:2000134,negative regulation of G1/S transition of mitotic cell cycle;GO:1903753,negative regulation of p38MAPK cascade;GO:0051898,negative regulation of protein kinase B signaling;GO:0042130,negative regulation of T cell proliferation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0099645,neurotransmitter receptor localization to postsynaptic specialization membrane;GO:0030432,peristalsis;GO:0030838,positive regulation of actin filament polymerization;GO:0008284,positive regulation of cell population proliferation;GO:0043268,positive regulation of potassium ion transport;GO:1903078,positive regulation of protein localization to plasma membrane;GO:0072659,protein localization to plasma membrane;GO:0043113,receptor clustering;GO:0097120,receptor localization to synapse;GO:0008360,regulation of cell shape;GO:0042391,regulation of membrane potential;GO:0031641,regulation of myelination;GO:2000310,regulation of NMDA receptor activity;GO:1903764,regulation of potassium ion export across plasma membrane;GO:1903286,regulation of potassium ion import;GO:1902473,regulation of protein localization to synapse;GO:1902305,regulation of sodium ion transmembrane transport;GO:0098911,regulation of ventricular cardiac muscle cell action potential;GO:1903760,regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:0048608,reproductive structure development;GO:0048745,smooth muscle tissue development;GO:0042110,T cell activation;GO:0016032,viral process	hsa:1739,path:hsa04390,Hippo signaling pathway;hsa:1739,path:hsa04530,Tight junction;hsa:1739,path:hsa04660,T cell receptor signaling pathway;hsa:1739,path:hsa05203,Viral carcinogenesis;hsa:1739,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:1739,path:hsa05165,Human papillomavirus infection
C1QC_HUMAN	P02747	C1QC	Complement C1q subcomponent subunit C	2.157248696	11.18215841	1.402810763	2.547025452	6.669703553	1.9749181075	6.669703553	1.9749181075	3.37720512444084	0.116307	0	0.29610283152865	0.115761	0	GO:0072562,blood microparticle;GO:0005581,collagen trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0098794,postsynapse;GO:0045202,synapse		GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0006955,immune response;GO:0045087,innate immune response;GO:0030853,negative regulation of granulocyte differentiation;GO:0045650,negative regulation of macrophage differentiation;GO:0030449,regulation of complement activation;GO:0098883,synapse pruning	hsa:714,path:hsa04610,Complement and coagulation cascades;hsa:714,path:hsa05322,Systemic lupus erythematosus;hsa:714,path:hsa05020,Prion diseases;hsa:714,path:hsa05133,Pertussis;hsa:714,path:hsa05150,Staphylococcus aureus infection;hsa:714,path:hsa05142,Chagas disease (American trypanosomiasis)
XRP2_HUMAN	O75695	RP2	Protein XRP2	0.172396162	0.179228153	0.263386254	0.346023766	0.1758121575	0.30470501	0.1758121575	0.30470501	0.576991357969467	0.295952	0	1.73312821099986	0.296244	0	GO:0005814,centriole;GO:0036064,ciliary basal body;GO:0005929,cilium;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:1990075,periciliary membrane compartment;GO:0005886,plasma membrane	GO:0005525,GTP binding;GO:0005096,GTPase activator activity;GO:0000287,magnesium ion binding;GO:0051082,unfolded protein binding	GO:0000902,cell morphogenesis;GO:0060271,cilium assembly;GO:0006892,post-Golgi vesicle-mediated transport;GO:0006457,protein folding;GO:0015031,protein transport;GO:0007601,visual perception	
CD11A_HUMAN	Q9UQ88	CDK11A	Cyclin-dependent kinase 11A	0.309704262	0.234310209	0.386531456	0.084539804	0.2720072355	0.23553563	0.2720072355	0.23553563	1.15484538581275	0.386217	0	0.865916781835019	0.385922	0	GO:0005737,cytoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0004693,cyclin-dependent protein serine/threonine kinase activity;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity	GO:0006915,apoptotic process;GO:0000278,mitotic cell cycle;GO:0006468,protein phosphorylation;GO:0001558,regulation of cell growth;GO:0007346,regulation of mitotic cell cycle;GO:0050684,regulation of mRNA processing;GO:0006355,regulation of transcription, DNA-templated	
CORO7_HUMAN	P57737	CORO7	Coronin-7	1.694558075	1.889749685	2.887762518	3.262075745	1.79215388	3.0749191315	1.79215388	3.0749191315	0.582829597578963	0.301290	0	1.71576736005504	0.301578	0	GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005802,trans-Golgi network	GO:0003779,actin binding;GO:0051015,actin filament binding	GO:0007015,actin filament organization;GO:0030041,actin filament polymerization;GO:0006895,Golgi to endosome transport;GO:0015031,protein transport	
HBE_HUMAN	P02100	HBE1	Hemoglobin subunit epsilon	0.276882544	0.130091424	0.302673547	3.369789371	0.203486984	1.836231459	0.203486984	1.836231459	0.110817720175003	0.001116	-1	9.02382758299666	0.001130	1	GO:0072562,blood microparticle;GO:0005829,cytosol;GO:0031838,haptoglobin-hemoglobin complex;GO:0005833,hemoglobin complex	GO:0020037,heme binding;GO:0031721,hemoglobin alpha binding;GO:0046872,metal ion binding;GO:0043177,organic acid binding;GO:0019825,oxygen binding;GO:0005344,oxygen carrier activity;GO:0044877,protein-containing complex binding	GO:0007596,blood coagulation;GO:0098869,cellular oxidant detoxification;GO:0042744,hydrogen peroxide catabolic process;GO:0014070,response to organic cyclic compound	
IMA3_HUMAN	O00629	KPNA4	Importin subunit alpha-3	0.214626038	0.135156198	0.542686757	2.55E-05	0.174891118	0.2713561285	0.174891118	0.2713561285	0.644507713781006	0.356822	0	1.55157180995321	0.357064	0	GO:0005829,cytosol;GO:0031965,nuclear membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0061608,nuclear import signal receptor activity;GO:0008139,nuclear localization sequence binding	GO:0019054,modulation by virus of host cellular process;GO:0006607,NLS-bearing protein import into nucleus	hsa:3840,path:hsa05132,Salmonella infection
HV43D_HUMAN	P0DP04	IGHV3-43D	Immunoglobulin heavy variable 3-43D	0.551178805	2.55E-05	0.122674722	1.331414173	0.2756021525	0.7270444475	0.2756021525	0.7270444475	0.37907194456636	0.119382	0	2.63802165877496	0.119697	0	GO:0009897,external side of plasma membrane;GO:0042571,immunoglobulin complex, circulating;GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane;GO:0019814,immunoglobulin complex	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006956,complement activation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
TINAL_HUMAN	Q9GZM7	TINAGL1	Tubulointerstitial nephritis antigen-like	0.018939896	0.557577133	0.177853843	2.279138979	0.2882585145	1.228496411	0.2882585145	1.228496411	0.23464335094423	0.027995	-1	4.26178707376916	0.028151	1	GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005764,lysosome	GO:0005201,extracellular matrix structural constituent;GO:0043236,laminin binding;GO:0008234,cysteine-type peptidase activity	GO:0016197,endosomal transport;GO:0006508,proteolysis	
AMBP_HUMAN	P02760	AMBP	Protein AMBP	3.310672232	0.711568799	2.332598805	7.541622207	2.0111205155	4.937110506	2.0111205155	4.937110506	0.407347681008135	0.142728	0	2.45490534652149	0.143056	0	GO:0072562,blood microparticle;GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043231,intracellular membrane-bounded organelle;GO:0005886,plasma membrane	GO:0019855,calcium channel inhibitor activity;GO:0046904,calcium oxalate binding;GO:0020037,heme binding;GO:0019862,IgA binding;GO:0042803,protein homodimerization activity;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0007155,cell adhesion;GO:0007565,female pregnancy;GO:0042167,heme catabolic process;GO:0050777,negative regulation of immune response;GO:0046329,negative regulation of JNK cascade;GO:0030163,protein catabolic process;GO:0018298,protein-chromophore linkage;GO:0006898,receptor-mediated endocytosis;GO:0016032,viral process	
MYO1C_HUMAN	O00159	MYO1C	Unconventional myosin-Ic	5.620652362	9.510768784	9.874275894	49.99413846	7.565710573	29.934207177	7.565710573	29.934207177	0.25274464522358	0.036125	-1	3.95656255789472	0.036307	1	GO:0015629,actin cytoskeleton;GO:0009925,basal plasma membrane;GO:0005903,brush border;GO:0005737,cytoplasm;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0031941,filamentous actin;GO:0016328,lateral plasma membrane;GO:0016020,membrane;GO:0045121,membrane raft;GO:0005902,microvillus;GO:0016604,nuclear body;GO:0005643,nuclear pore;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0045335,phagocytic vesicle;GO:0005886,plasma membrane;GO:0032587,ruffle membrane;GO:0060171,stereocilium membrane;GO:0016461,unconventional myosin complex;GO:0031982,vesicle;GO:0016459,myosin complex	GO:0051015,actin filament binding;GO:0030898,actin-dependent ATPase activity;GO:0005524,ATP binding;GO:0005516,calmodulin binding;GO:0000146,microfilament motor activity;GO:0008022,protein C-terminus binding;GO:0005102,signaling receptor binding;GO:0031267,small GTPase binding;GO:0003779,actin binding;GO:0003774,motor activity	GO:0007015,actin filament organization;GO:0071346,cellular response to interferon-gamma;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0051028,mRNA transport;GO:0030838,positive regulation of actin filament polymerization;GO:0030335,positive regulation of cell migration;GO:0038089,positive regulation of cell migration by vascular endothelial growth factor signaling pathway;GO:1900078,positive regulation of cellular response to insulin stimulus;GO:0045815,positive regulation of gene expression, epigenetic;GO:0090314,positive regulation of protein targeting to membrane;GO:1900748,positive regulation of vascular endothelial growth factor signaling pathway;GO:0006605,protein targeting;GO:0006612,protein targeting to membrane;GO:2000810,regulation of bicellular tight junction assembly;GO:0030050,vesicle transport along actin filament	hsa:4641,path:hsa05130,Pathogenic Escherichia coli infection
RLA0_HUMAN	P05388	RPLP0	60S acidic ribosomal protein P0	16.89045702	8.999959727	22.23778586	8.25898611	12.9452083735	15.248385985	12.9452083735	15.248385985	0.848955973847615	0.488101	0	1.17791738418169	0.488024	0	GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0030425,dendrite;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005634,nucleus;GO:0098794,postsynapse;GO:0014069,postsynaptic density;GO:1990904,ribonucleoprotein complex;GO:0005840,ribosome	GO:0070180,large ribosomal subunit rRNA binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0071353,cellular response to interleukin-4;GO:0002181,cytoplasmic translation;GO:0035722,interleukin-12-mediated signaling pathway;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000027,ribosomal large subunit assembly;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription;GO:0042254,ribosome biogenesis	hsa:6175,path:hsa03010,Ribosome
RAVR1_HUMAN	Q8IY67	RAVER1	Ribonucleoprotein PTB-binding 1	0.030838181	2.55E-05	0.053442872	2.55E-05	0.0154318405	0.026734186	0.0154318405	0.026734186	0.577232480540085	0.296173	0	1.73240424562449	0.296464	0	GO:0005737,cytoplasm;GO:0005634,nucleus	GO:0003676,nucleic acid binding;GO:0003723,RNA binding	GO:0000398,mRNA splicing, via spliceosome	
NAA15_HUMAN	Q9BXJ9	NAA15	N-alpha-acetyltransferase 15, NatA auxiliary subunit	1.12495187	0.472024874	1.115736634	0.603697205	0.798488372	0.8597169195	0.798488372	0.8597169195	0.928780571707709	0.457960	0	1.07668057500529	0.457816	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0031415,NatA complex;GO:0016604,nuclear body;GO:0005634,nucleus;GO:0005667,transcription regulator complex	GO:0043022,ribosome binding;GO:0003723,RNA binding	GO:0001525,angiogenesis;GO:0030154,cell differentiation;GO:0017196,N-terminal peptidyl-methionine acetylation;GO:0006474,N-terminal protein amino acid acetylation;GO:0043066,negative regulation of apoptotic process;GO:0045893,positive regulation of transcription, DNA-templated;GO:0050821,protein stabilization	
CO5_HUMAN	P01031	C5	Complement C5	1.966343898	1.208354054	2.35550012	10.21431236	1.587348976	6.28490624	1.587348976	6.28490624	0.252565259589298	0.036039	-1	3.95937272460243	0.036221	1	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005579,membrane attack complex	GO:0008009,chemokine activity;GO:0004866,endopeptidase inhibitor activity;GO:0005102,signaling receptor binding	GO:0000187,activation of MAPK activity;GO:0007166,cell surface receptor signaling pathway;GO:0006935,chemotaxis;GO:0006956,complement activation;GO:0006957,complement activation, alternative pathway;GO:0006958,complement activation, classical pathway;GO:0019835,cytolysis;GO:0007186,G protein-coupled receptor signaling pathway;GO:0001701,in utero embryonic development;GO:0006954,inflammatory response;GO:0010760,negative regulation of macrophage chemotaxis;GO:0045766,positive regulation of angiogenesis;GO:0032722,positive regulation of chemokine production;GO:0010575,positive regulation of vascular endothelial growth factor production;GO:0030449,regulation of complement activation	hsa:727,path:hsa04080,Neuroactive ligand-receptor interaction;hsa:727,path:hsa04610,Complement and coagulation cascades;hsa:727,path:hsa05322,Systemic lupus erythematosus;hsa:727,path:hsa05020,Prion diseases;hsa:727,path:hsa05133,Pertussis;hsa:727,path:hsa05150,Staphylococcus aureus infection;hsa:727,path:hsa05168,Herpes simplex virus 1 infection
HEXA_HUMAN	P06865	HEXA	Beta-hexosaminidase subunit alpha	1.712878578	2.590068821	3.774190194	1.733025697	2.1514736995	2.7536079455	2.1514736995	2.7536079455	0.781328984402438	0.470994	0	1.27987060503688	0.471118	0	GO:0042582,azurophil granule;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0043202,lysosomal lumen;GO:0016020,membrane;GO:0005764,lysosome	GO:0008375,acetylglucosaminyltransferase activity;GO:0004563,beta-N-acetylhexosaminidase activity;GO:0102148,N-acetyl-beta-D-galactosaminidase activity;GO:0046982,protein heterodimerization activity;GO:0016787,hydrolase activity	GO:0005975,carbohydrate metabolic process;GO:0030207,chondroitin sulfate catabolic process;GO:0006689,ganglioside catabolic process;GO:0006024,glycosaminoglycan biosynthetic process;GO:0006687,glycosphingolipid metabolic process;GO:0030214,hyaluronan catabolic process;GO:0042340,keratan sulfate catabolic process	hsa:3073,path:hsa00520,Amino sugar and nucleotide sugar metabolism;hsa:3073,path:hsa00513,Various types of N-glycan biosynthesis;hsa:3073,path:hsa00531,Glycosaminoglycan degradation;hsa:3073,path:hsa00603,Glycosphingolipid biosynthesis - globo and isoglobo series;hsa:3073,path:hsa00604,Glycosphingolipid biosynthesis - ganglio series;hsa:3073,path:hsa00511,Other glycan degradation;hsa:3073,path:hsa04142,Lysosome
HV434_HUMAN	P06331	IGHV4-34	Immunoglobulin heavy variable 4-34	4.626049857	2.966981818	4.145338823	11.23271465	3.7965158375	7.6890267365	3.7965158375	7.6890267365	0.493757658492439	0.219422	0	2.02528504176166	0.219752	0	GO:0009897,external side of plasma membrane;GO:0042571,immunoglobulin complex, circulating;GO:0005576,extracellular region;GO:0005886,plasma membrane	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006956,complement activation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response	
GALNS_HUMAN	P34059	GALNS	N-acetylgalactosamine-6-sulfatase	0.017501421	0.11400709	0.028832097	2.55E-05	0.0657542555	0.0144287985	0.0657542555	0.0144287985	4.55715390993921	0.074058	0	0.219435204463687	0.073589	0	GO:0035578,azurophil granule lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0043202,lysosomal lumen	GO:0004065,arylsulfatase activity;GO:0046872,metal ion binding;GO:0003943,N-acetylgalactosamine-4-sulfatase activity;GO:0043890,N-acetylgalactosamine-6-sulfatase activity;GO:0008484,sulfuric ester hydrolase activity	GO:0042340,keratan sulfate catabolic process;GO:0043312,neutrophil degranulation	hsa:2588,path:hsa00531,Glycosaminoglycan degradation;hsa:2588,path:hsa04142,Lysosome
PLSI_HUMAN	Q14651	PLS1	Plastin-1	0.065602755	0.099513993	0.223690686	0.173863413	0.082558374	0.1987770495	0.082558374	0.1987770495	0.415331519446867	0.149523	0	2.40771517011709	0.149854	0	GO:0005884,actin filament;GO:0032432,actin filament bundle;GO:0005903,brush border;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0032420,stereocilium;GO:1990357,terminal web	GO:0051015,actin filament binding;GO:0005509,calcium ion binding;GO:0005200,structural constituent of cytoskeleton	GO:0051017,actin filament bundle assembly;GO:0051639,actin filament network formation;GO:0060088,auditory receptor cell stereocilium organization;GO:0001951,intestinal D-glucose absorption;GO:0040018,positive regulation of multicellular organism growth;GO:1903078,positive regulation of protein localization to plasma membrane;GO:0032532,regulation of microvillus length;GO:1902896,terminal web assembly;GO:0060121,vestibular receptor cell stereocilium organization	
LSM2_HUMAN	Q9Y333	LSM2	U6 snRNA-associated Sm-like protein LSm2	0.315814946	0.294806181	0.484485495	0.029351027	0.3053105635	0.256918261	0.3053105635	0.256918261	1.18835680387857	0.377025	0	0.841498106238961	0.376712	0	GO:0071013,catalytic step 2 spliceosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:1990726,Lsm1-7-Pat1 complex;GO:0120115,Lsm2-8 complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body;GO:0071011,precatalytic spliceosome;GO:0071005,U2-type precatalytic spliceosome;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005688,U6 snRNP	GO:0003723,RNA binding;GO:0031267,small GTPase binding;GO:0017070,U6 snRNA binding	GO:0043928,exonucleolytic catabolism of deadenylated mRNA;GO:0006402,mRNA catabolic process;GO:0000398,mRNA splicing, via spliceosome;GO:0000244,spliceosomal tri-snRNP complex assembly	hsa:57819,path:hsa03040,Spliceosome;hsa:57819,path:hsa03018,RNA degradation
TBCA_HUMAN	O75347	TBCA	Tubulin-specific chaperone A	3.221921968	2.719107682	0.300160098	0.314729597	2.970514825	0.3074448475	2.970514825	0.3074448475	9.66194375724576	0.018780	1	0.103498842999378	0.018562	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005874,microtubule;GO:0015630,microtubule cytoskeleton;GO:0005730,nucleolus	GO:0048487,beta-tubulin binding;GO:0051087,chaperone binding;GO:0003723,RNA binding;GO:0015631,tubulin binding	GO:0007023,post-chaperonin tubulin folding pathway;GO:0006457,protein folding;GO:0007021,tubulin complex assembly	
ENPL_HUMAN	P14625	HSP90B1	Endoplasmin	128.6604596	116.6222984	154.6507196	130.7510955	122.641379	142.70090755	122.641379	142.70090755	0.859429565695148	0.483980	0	1.16356248367038	0.483894	0	GO:0062023,collagen-containing extracellular matrix;GO:0005829,cytosol;GO:0071682,endocytic vesicle lumen;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005925,focal adhesion;GO:0042470,melanosome;GO:0016020,membrane;GO:0030496,midbody;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0032991,protein-containing complex;GO:0033018,sarcoplasmic reticulum lumen	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0005509,calcium ion binding;GO:0050750,low-density lipoprotein particle receptor binding;GO:0019903,protein phosphatase binding;GO:0003723,RNA binding;GO:0051082,unfolded protein binding	GO:0031247,actin rod assembly;GO:0036500,ATF6-mediated unfolded protein response;GO:0044267,cellular protein metabolic process;GO:0071318,cellular response to ATP;GO:0019221,cytokine-mediated signaling pathway;GO:0043066,negative regulation of apoptotic process;GO:0043687,post-translational protein modification;GO:0006457,protein folding;GO:0034975,protein folding in endoplasmic reticulum;GO:0015031,protein transport;GO:0006898,receptor-mediated endocytosis;GO:0043666,regulation of phosphoprotein phosphatase activity;GO:0034976,response to endoplasmic reticulum stress;GO:0001666,response to hypoxia;GO:0030970,retrograde protein transport, ER to cytosol;GO:0051208,sequestering of calcium ion;GO:0002224,toll-like receptor signaling pathway;GO:0030433,ubiquitin-dependent ERAD pathway	hsa:7184,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:7184,path:hsa04151,PI3K-Akt signaling pathway;hsa:7184,path:hsa04657,IL-17 signaling pathway;hsa:7184,path:hsa04915,Estrogen signaling pathway;hsa:7184,path:hsa04918,Thyroid hormone synthesis;hsa:7184,path:hsa05200,Pathways in cancer;hsa:7184,path:hsa05215,Prostate cancer;hsa:7184,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:7184,path:hsa05132,Salmonella infection
DCTN1_HUMAN	Q14203	DCTN1	Dynactin subunit 1	2.745041656	1.998274532	3.111785527	3.893120203	2.371658094	3.502452865	2.371658094	3.502452865	0.677142044565388	0.385342	0	1.47679502111235	0.385556	0	GO:0030424,axon;GO:0005938,cell cortex;GO:0099738,cell cortex region;GO:0120103,centriolar subdistal appendage;GO:0005814,centriole;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030286,dynein complex;GO:0045171,intercellular bridge;GO:0000776,kinetochore;GO:0016020,membrane;GO:0005874,microtubule;GO:0005875,microtubule associated complex;GO:0015630,microtubule cytoskeleton;GO:0035371,microtubule plus-end;GO:0072686,mitotic spindle;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0005635,nuclear envelope;GO:0005634,nucleus;GO:0005819,spindle;GO:0000922,spindle pole	GO:0008017,microtubule binding;GO:0051010,microtubule plus-end binding;GO:0019901,protein kinase binding;GO:0048156,tau protein binding;GO:0015631,tubulin binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0051301,cell division;GO:0010457,centriole-centriole cohesion;GO:0097711,ciliary basal body-plasma membrane docking;GO:0031122,cytoplasmic microtubule organization;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0000132,establishment of mitotic spindle orientation;GO:0000086,G2/M transition of mitotic cell cycle;GO:0036498,IRE1-mediated unfolded protein response;GO:0099558,maintenance of synapse structure;GO:0034454,microtubule anchoring at centrosome;GO:0000278,mitotic cell cycle;GO:0061744,motor behavior;GO:0007399,nervous system development;GO:0007528,neuromuscular junction development;GO:0050905,neuromuscular process;GO:0070050,neuron cellular homeostasis;GO:1990535,neuron projection maintenance;GO:1905515,non-motile cilium assembly;GO:0051081,nuclear envelope disassembly;GO:0007097,nuclear migration;GO:0090063,positive regulation of microtubule nucleation;GO:0031116,positive regulation of microtubule polymerization;GO:1904398,positive regulation of neuromuscular junction development;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0060236,regulation of mitotic spindle organization;GO:0042147,retrograde transport, endosome to Golgi;GO:0021517,ventral spinal cord development	hsa:1639,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:1639,path:hsa05016,Huntington disease
S27A1_HUMAN	Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	0.108665475	0.206019031	0.2664364	0.218080725	0.157342253	0.2422585625	0.157342253	0.2422585625	0.649480667994965	0.361212	0	1.53969170951175	0.361450	0	GO:0009925,basal plasma membrane;GO:0005783,endoplasmic reticulum;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0047676,arachidonate-CoA ligase activity;GO:0015225,biotin transmembrane transporter activity;GO:0015562,efflux transmembrane transporter activity;GO:0015245,fatty acid transmembrane transporter activity;GO:0005324,long-chain fatty acid transporter activity;GO:0004467,long-chain fatty acid-CoA ligase activity;GO:0000166,nucleotide binding;GO:1901480,oleate transmembrane transporter activity;GO:0090434,oleoyl-CoA ligase activity;GO:0031957,very long-chain fatty acid-CoA ligase activity	GO:0033211,adiponectin-activated signaling pathway;GO:1905135,biotin import across plasma membrane;GO:0015878,biotin transport;GO:0032049,cardiolipin biosynthetic process;GO:0140115,export across plasma membrane;GO:0044381,glucose import in response to insulin stimulus;GO:1990379,lipid transport across blood-brain barrier;GO:0015911,long-chain fatty acid import across plasma membrane;GO:0044539,long-chain fatty acid import into cell;GO:0015909,long-chain fatty acid transport;GO:0001579,medium-chain fatty acid transport;GO:0071072,negative regulation of phospholipid biosynthetic process;GO:0006654,phosphatidic acid biosynthetic process;GO:0006656,phosphatidylcholine biosynthetic process;GO:0006646,phosphatidylethanolamine biosynthetic process;GO:0006655,phosphatidylglycerol biosynthetic process;GO:0006661,phosphatidylinositol biosynthetic process;GO:0006659,phosphatidylserine biosynthetic process;GO:0031652,positive regulation of heat generation;GO:0071902,positive regulation of protein serine/threonine kinase activity;GO:0010867,positive regulation of triglyceride biosynthetic process;GO:0019222,regulation of metabolic process;GO:0009409,response to cold;GO:0032868,response to insulin;GO:0150104,transport across blood-brain barrier	hsa:376497,path:hsa03320,PPAR signaling pathway;hsa:376497,path:hsa04931,Insulin resistance
TWF1_HUMAN	Q12792	TWF1	Twinfilin-1	1.28481021	1.762624686	1.452271927	0.799282041	1.523717448	1.125776984	1.523717448	1.125776984	1.35348072456241	0.336160	0	0.738835789717885	0.335770	0	GO:0015629,actin cytoskeleton;GO:0005884,actin filament;GO:0005911,cell-cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030175,filopodium;GO:0005925,focal adhesion;GO:0030016,myofibril;GO:0005730,nucleolus;GO:0048471,perinuclear region of cytoplasm;GO:0005856,cytoskeleton	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0003785,actin monomer binding;GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding	GO:0030042,actin filament depolymerization;GO:0051016,barbed-end actin filament capping;GO:0030837,negative regulation of actin filament polymerization;GO:0018108,peptidyl-tyrosine phosphorylation;GO:0010976,positive regulation of neuron projection development;GO:0043538,regulation of actin phosphorylation;GO:0010591,regulation of lamellipodium assembly;GO:0042989,sequestering of actin monomers	
MTAP_HUMAN	Q13126	MTAP	S-methyl-5'-thioadenosine phosphorylase	0.905287015	0.595169257	1.533354256	1.251184431	0.750228136	1.3922693435	0.750228136	1.3922693435	0.538852729540116	0.260896	0	1.85579462658276	0.261209	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005737,cytoplasm;GO:0005634,nucleus	GO:0004645,1,4-alpha-oligoglucan phosphorylase activity;GO:0017061,S-methyl-5-thioadenosine phosphorylase activity	GO:0035722,interleukin-12-mediated signaling pathway;GO:0019509,L-methionine salvage from methylthioadenosine;GO:0006139,nucleobase-containing compound metabolic process;GO:0006166,purine ribonucleoside salvage;GO:0033574,response to testosterone;GO:0009116,nucleoside metabolic process	hsa:4507,path:hsa00270,Cysteine and methionine metabolism
CPT2_HUMAN	P23786	CPT2	Carnitine O-palmitoyltransferase 2, mitochondrial	3.289870693	2.004286923	4.748343559	3.601740492	2.647078808	4.1750420255	2.647078808	4.1750420255	0.634024470132846	0.347519	0	1.57722619095517	0.347769	0	GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005654,nucleoplasm	GO:0008458,carnitine O-octanoyltransferase activity;GO:0004095,carnitine O-palmitoyltransferase activity;GO:0016746,transferase activity, transferring acyl groups	GO:0009437,carnitine metabolic process;GO:0006853,carnitine shuttle;GO:0006635,fatty acid beta-oxidation;GO:0001676,long-chain fatty acid metabolic process;GO:0120162,positive regulation of cold-induced thermogenesis;GO:0019222,regulation of metabolic process;GO:0001701,in utero embryonic development	hsa:1376,path:hsa00071,Fatty acid degradation;hsa:1376,path:hsa03320,PPAR signaling pathway;hsa:1376,path:hsa04714,Thermogenesis
ANXA6_HUMAN	P08133	ANXA6	Annexin A6	53.2720618	46.72976381	77.40466884	103.2746934	50.000912805	90.33968112	50.000912805	90.33968112	0.553476746708712	0.274365	0	1.80676063799712	0.274671	0	GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0042470,melanosome;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0048471,perinuclear region of cytoplasm	GO:0051015,actin filament binding;GO:0005262,calcium channel activity;GO:0005509,calcium ion binding;GO:0005544,calcium-dependent phospholipid binding;GO:0048306,calcium-dependent protein binding;GO:0015485,cholesterol binding;GO:0035374,chondroitin sulfate binding;GO:0005525,GTP binding;GO:0042802,identical protein binding;GO:0015276,ligand-gated ion channel activity;GO:0008289,lipid binding;GO:0001786,phosphatidylserine binding	GO:0097190,apoptotic signaling pathway;GO:0003418,growth plate cartilage chondrocyte differentiation;GO:0034220,ion transmembrane transport;GO:0051560,mitochondrial calcium ion homeostasis;GO:0051283,negative regulation of sequestering of calcium ion;GO:0001755,neural crest cell migration;GO:0001778,plasma membrane repair;GO:0006937,regulation of muscle contraction	
NCF4_HUMAN	Q15080	NCF4	Neutrophil cytosol factor 4	0.737000142	0.382199188	0.748820856	0.550290335	0.559599665	0.6495555955	0.559599665	0.6495555955	0.861511576340504	0.483167	0	1.16075050813335	0.483080	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0010008,endosome membrane;GO:0016020,membrane;GO:0043020,NADPH oxidase complex;GO:0032010,phagolysosome	GO:0060090,molecular adaptor activity;GO:0032266,phosphatidylinositol-3-phosphate binding;GO:0016175,superoxide-generating NAD(P)H oxidase activity;GO:0016176,superoxide-generating NADPH oxidase activator activity;GO:0035091,phosphatidylinositol binding	GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0045454,cell redox homeostasis;GO:0034599,cellular response to oxidative stress;GO:0006909,phagocytosis;GO:0045730,respiratory burst;GO:0042554,superoxide anion generation;GO:0006801,superoxide metabolic process;GO:0048010,vascular endothelial growth factor receptor signaling pathway	hsa:4689,path:hsa04145,Phagosome;hsa:4689,path:hsa04670,Leukocyte transendothelial migration;hsa:4689,path:hsa04380,Osteoclast differentiation;hsa:4689,path:hsa05140,Leishmaniasis
ENOB_HUMAN	P13929	ENO3	Beta-enolase	0.991242403	2.55E-05	0.137823428	1.159436177	0.4956339515	0.6486298025	0.4956339515	0.6486298025	0.764124543136453	0.457475	0	1.3086871884724	0.457614	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0016020,membrane;GO:0000015,phosphopyruvate hydratase complex;GO:0005886,plasma membrane	GO:0042802,identical protein binding;GO:0000287,magnesium ion binding;GO:0004634,phosphopyruvate hydratase activity;GO:0044877,protein-containing complex binding	GO:0007568,aging;GO:0061621,canonical glycolysis;GO:0006094,gluconeogenesis;GO:0006096,glycolytic process;GO:0032889,regulation of vacuole fusion, non-autophagic;GO:0042493,response to drug;GO:0043403,skeletal muscle tissue regeneration;GO:0021762,substantia nigra development	hsa:2027,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:2027,path:hsa03018,RNA degradation;hsa:2027,path:hsa04066,HIF-1 signaling pathway
ASC_HUMAN	Q9ULZ3	PYCARD	Apoptosis-associated speck-like protein containing a CARD	1.431175281	7.310531144	0.35403654	0.194518034	4.3708532125	0.274277287	4.3708532125	0.274277287	15.9358919592201	0.006186	1	0.0627514294498857	0.006087	-1	GO:0097169,AIM2 inflammasome complex;GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005576,extracellular region;GO:0000139,Golgi membrane;GO:0008385,IkappaB kinase complex;GO:0005739,mitochondrion;GO:0043025,neuronal cell body;GO:0072558,NLRP1 inflammasome complex;GO:0072559,NLRP3 inflammasome complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0034774,secretory granule lumen	GO:0070700,BMP receptor binding;GO:0008656,cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0097153,cysteine-type endopeptidase activity involved in apoptotic process;GO:0019899,enzyme binding;GO:0042802,identical protein binding;GO:0005138,interleukin-6 receptor binding;GO:0044325,ion channel binding;GO:0017024,myosin I binding;GO:0002020,protease binding;GO:0046983,protein dimerization activity;GO:0042803,protein homodimerization activity;GO:0032090,Pyrin domain binding;GO:0005523,tropomyosin binding;GO:0004197,cysteine-type endopeptidase activity	GO:0097202,activation of cysteine-type endopeptidase activity;GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0002218,activation of innate immune response;GO:0006915,apoptotic process;GO:0071347,cellular response to interleukin-1;GO:0071222,cellular response to lipopolysaccharide;GO:0071356,cellular response to tumor necrosis factor;GO:0050829,defense response to Gram-negative bacterium;GO:0051607,defense response to virus;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0072332,intrinsic apoptotic signaling pathway by p53 class mediator;GO:0042771,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0044351,macropinocytosis;GO:0001773,myeloid dendritic cell activation;GO:0002277,myeloid dendritic cell activation involved in immune response;GO:1900016,negative regulation of cytokine production involved in inflammatory response;GO:0043124,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0032688,negative regulation of interferon-beta production;GO:0032088,negative regulation of NF-kappaB transcription factor activity;GO:0071901,negative regulation of protein serine/threonine kinase activity;GO:0043312,neutrophil degranulation;GO:0030838,positive regulation of actin filament polymerization;GO:0042104,positive regulation of activated T cell proliferation;GO:0002821,positive regulation of adaptive immune response;GO:0002588,positive regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0043065,positive regulation of apoptotic process;GO:0032722,positive regulation of chemokine production;GO:2001056,positive regulation of cysteine-type endopeptidase activity;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0002230,positive regulation of defense response to virus by host;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:2001238,positive regulation of extrinsic apoptotic signaling pathway;GO:0032729,positive regulation of interferon-gamma production;GO:0032731,positive regulation of interleukin-1 beta production;GO:0032733,positive regulation of interleukin-10 production;GO:0032755,positive regulation of interleukin-6 production;GO:0032757,positive regulation of interleukin-8 production;GO:0046330,positive regulation of JNK cascade;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0050766,positive regulation of phagocytosis;GO:0090200,positive regulation of release of cytochrome c from mitochondria;GO:0050870,positive regulation of T cell activation;GO:2000406,positive regulation of T cell migration;GO:0032760,positive regulation of tumor necrosis factor production;GO:0051260,protein homooligomerization;GO:0035590,purinergic nucleotide receptor signaling pathway;GO:0010506,regulation of autophagy;GO:0043087,regulation of GTPase activity;GO:0050727,regulation of inflammatory response;GO:2001242,regulation of intrinsic apoptotic signaling pathway;GO:0031647,regulation of protein stability;GO:0010803,regulation of tumor necrosis factor-mediated signaling pathway;GO:0007165,signal transduction;GO:0033209,tumor necrosis factor-mediated signaling pathway	hsa:29108,path:hsa04217,Necroptosis;hsa:29108,path:hsa04621,NOD-like receptor signaling pathway;hsa:29108,path:hsa04623,Cytosolic DNA-sensing pathway;hsa:29108,path:hsa04625,C-type lectin receptor signaling pathway;hsa:29108,path:hsa05130,Pathogenic Escherichia coli infection;hsa:29108,path:hsa05132,Salmonella infection;hsa:29108,path:hsa05131,Shigellosis;hsa:29108,path:hsa05135,Yersinia infection;hsa:29108,path:hsa05133,Pertussis;hsa:29108,path:hsa05134,Legionellosis;hsa:29108,path:hsa05164,Influenza A
PERM_HUMAN	P05164	MPO	Myeloperoxidase	6.786321009	13.23701269	13.1010906	33.57266385	10.0116668495	23.336877225	10.0116668495	23.336877225	0.429006278473919	0.161338	0	2.33096821696234	0.161672	0	GO:0042582,azurophil granule;GO:0035578,azurophil granule lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043231,intracellular membrane-bounded organelle;GO:0005764,lysosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0097013,phagocytic vesicle lumen;GO:0030141,secretory granule	GO:0003682,chromatin binding;GO:0020037,heme binding;GO:0008201,heparin binding;GO:0046872,metal ion binding;GO:0004601,peroxidase activity	GO:0007568,aging;GO:0045454,cell redox homeostasis;GO:0006952,defense response;GO:0042742,defense response to bacterium;GO:0050832,defense response to fungus;GO:0042744,hydrogen peroxide catabolic process;GO:0002149,hypochlorous acid biosynthetic process;GO:0034374,low-density lipoprotein particle remodeling;GO:0043066,negative regulation of apoptotic process;GO:0043312,neutrophil degranulation;GO:0019430,removal of superoxide radicals;GO:0002679,respiratory burst involved in defense response;GO:0032094,response to food;GO:1990268,response to gold nanoparticle;GO:0032496,response to lipopolysaccharide;GO:0009612,response to mechanical stimulus;GO:0006979,response to oxidative stress;GO:0001878,response to yeast	hsa:4353,path:hsa00983,Drug metabolism - other enzymes;hsa:4353,path:hsa04145,Phagosome;hsa:4353,path:hsa05202,Transcriptional misregulation in cancer;hsa:4353,path:hsa05221,Acute myeloid leukemia
GAPD1_HUMAN	Q14C86	GAPVD1	GTPase-activating protein and VPS9 domain-containing protein 1	5.030911907	4.251207701	5.583624975	7.115333528	4.641059804	6.3494792515	4.641059804	6.3494792515	0.730935501978937	0.430674	0	1.36810976795161	0.430842	0	GO:0005829,cytosol;GO:0005768,endosome;GO:0005886,plasma membrane	GO:0045296,cadherin binding;GO:0032794,GTPase activating protein binding;GO:0005096,GTPase activator activity;GO:0005085,guanyl-nucleotide exchange factor activity	GO:0006897,endocytosis;GO:0061024,membrane organization;GO:0043547,positive regulation of GTPase activity;GO:0051223,regulation of protein transport;GO:0007165,signal transduction;GO:0043087,regulation of GTPase activity	
EF1G_HUMAN	P26641	EEF1G	Elongation factor 1-gamma	24.63752479	15.47256622	29.38599838	12.74941084	20.055045505	21.06770461	20.055045505	21.06770461	0.951933106916672	0.449736	0	1.05049398191331	0.449574	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005634,nucleus	GO:0045296,cadherin binding;GO:0003746,translation elongation factor activity	GO:0006749,glutathione metabolic process;GO:0009615,response to virus;GO:0006414,translational elongation	hsa:1937,path:hsa05134,Legionellosis
AOC3_HUMAN	Q16853	AOC3	Membrane primary amine oxidase	4.948135829	7.138391152	9.512808109	133.051024	6.0432634905	71.2819160545	6.0432634905	71.2819160545	0.0847797565637756	0.000263	-1	11.7952685939567	0.000267	1	GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0005769,early endosome;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane;GO:0005902,microvillus;GO:0005886,plasma membrane	GO:0052595,aliphatic-amine oxidase activity;GO:0052594,aminoacetone;GO:0005509,calcium ion binding;GO:0005507,copper ion binding;GO:0042802,identical protein binding;GO:0052596,phenethylamine;GO:0008131,primary amine oxidase activity;GO:0046982,protein heterodimerization activity;GO:0048038,quinone binding;GO:0052593,tryptamine	GO:0009308,amine metabolic process;GO:0007155,cell adhesion;GO:0006954,inflammatory response;GO:1902283,negative regulation of primary amine oxidase activity;GO:0046677,response to antibiotic;GO:0006805,xenobiotic metabolic process	hsa:8639,path:hsa00260,Glycine, serine and threonine metabolism;hsa:8639,path:hsa00350,Tyrosine metabolism;hsa:8639,path:hsa00360,Phenylalanine metabolism;hsa:8639,path:hsa00410,beta-Alanine metabolism
VP26B_HUMAN	Q4G0F5	VPS26B	Vacuolar protein sorting-associated protein 26B	1.013900152	1.398798144	1.00345561	5.616688987	1.206349148	3.3100722985	1.206349148	3.3100722985	0.364447975516025	0.107820	0	2.74387585384194	0.108126	0	GO:0005829,cytosol;GO:0005769,early endosome;GO:0005768,endosome;GO:0005770,late endosome;GO:0045335,phagocytic vesicle;GO:0030904,retromer complex;GO:0030906,retromer, cargo-selective complex;GO:0016021,integral component of membrane		GO:0071346,cellular response to interferon-gamma;GO:0006886,intracellular protein transport;GO:0016241,regulation of macroautophagy;GO:0042147,retrograde transport, endosome to Golgi	hsa:112936,path:hsa04144,Endocytosis
H2A2C_HUMAN	Q16777	H2AC20	Histone H2A type 2-C	0.542070003	0.476493228	0.735816542	0.426274771	0.5092816155	0.5810456565	0.5092816155	0.5810456565	0.876491562758976	0.477378	0	1.14091229452597	0.477277	0	GO:0070062,extracellular exosome;GO:0000786,nucleosome;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0046982,protein heterodimerization activity	GO:0006342,chromatin silencing	hsa:8338,path:hsa04217,Necroptosis;hsa:8338,path:hsa05322,Systemic lupus erythematosus;hsa:8338,path:hsa05034,Alcoholism
GRWD1_HUMAN	Q9BQ67	GRWD1	Glutamate-rich WD repeat-containing protein 1	0.040061308	0.011981995	0.118981306	0.052426954	0.0260216515	0.08570413	0.0260216515	0.08570413	0.303621908302435	0.064600	0	3.29356997191358	0.064850	0	GO:0005694,chromosome;GO:0005829,cytosol;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0003682,chromatin binding;GO:0003688,DNA replication origin binding;GO:0042393,histone binding;GO:0003723,RNA binding	GO:0006260,DNA replication;GO:0006334,nucleosome assembly;GO:0006337,nucleosome disassembly	
ABR_HUMAN	Q12979	ABR	Active breakpoint cluster region-related protein	0.764768695	1.349376208	1.233159554	0.401894522	1.0570724515	0.817527038	1.0570724515	0.817527038	1.29301222145022	0.350325	0	0.77338789487884	0.349961	0	GO:0030424,axon;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0098978,glutamatergic synapse;GO:0016020,membrane;GO:0098685,Schaffer collateral - CA1 synapse	GO:0005096,GTPase activator activity;GO:0005085,guanyl-nucleotide exchange factor activity;GO:0004674,protein serine/threonine kinase activity	GO:0090630,activation of GTPase activity;GO:0007186,G protein-coupled receptor signaling pathway;GO:0050804,modulation of chemical synaptic transmission;GO:0043065,positive regulation of apoptotic process;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007264,small GTPase mediated signal transduction;GO:0035556,intracellular signal transduction;GO:0043547,positive regulation of GTPase activity;GO:0007165,signal transduction	
VAC14_HUMAN	Q08AM6	VAC14	Protein VAC14 homolog	0.601780532	0.887671659	0.77343569	0.373719833	0.7447260955	0.5735777615	0.7447260955	0.5735777615	1.29838732511599	0.349030	0	0.77018619995437	0.348663	0	GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0005783,endoplasmic reticulum;GO:0010008,endosome membrane;GO:0000306,extrinsic component of vacuolar membrane;GO:0000139,Golgi membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0031902,late endosome membrane;GO:0070772,PAS complex	GO:0042802,identical protein binding;GO:0038023,signaling receptor activity	GO:0006661,phosphatidylinositol biosynthetic process;GO:0033674,positive regulation of kinase activity;GO:0007165,signal transduction;GO:0016032,viral process	hsa:55697,path:hsa05203,Viral carcinogenesis;hsa:55697,path:hsa05166,Human T-cell leukemia virus 1 infection
CASPE_HUMAN	P31944	CASP14	Caspase-14	0.999958632	0.28727121	0.328726005	0.017375272	0.643614921	0.1730506385	0.643614921	0.1730506385	3.71922881405607	0.101161	0	0.268872943826608	0.100636	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0045095,keratin filament;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0004197,cysteine-type endopeptidase activity;GO:0097200,cysteine-type endopeptidase activity involved in execution phase of apoptosis	GO:0070268,cornification;GO:0008544,epidermis development;GO:0031424,keratinization	
EPCR_HUMAN	Q9UNN8	PROCR	Endothelial protein C receptor	2.55E-05	0.16548441	0.121735506	0.437392296	0.082754955	0.279563901	0.082754955	0.279563901	0.29601445216634	0.059849	0	3.37821343749145	0.060089	0	GO:0009986,cell surface;GO:0005813,centrosome;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0005887,integral component of plasma membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane	GO:0038023,signaling receptor activity	GO:0007596,blood coagulation;GO:0050819,negative regulation of coagulation	hsa:10544,path:hsa04610,Complement and coagulation cascades
H2A3_HUMAN	Q7L7L0	H2AW	Histone H2A type 3	72.71687963	113.4182492	24.36238239	27.78477251	93.067564415	26.07357745	93.067564415	26.07357745	3.56942059805453	0.107430	0	0.280157513671838	0.106896	0	GO:0070062,extracellular exosome;GO:0000786,nucleosome;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0046982,protein heterodimerization activity	GO:0006342,chromatin silencing;GO:0006337,nucleosome disassembly;GO:0070914,UV-damage excision repair	hsa:92815,path:hsa04217,Necroptosis;hsa:92815,path:hsa05322,Systemic lupus erythematosus;hsa:92815,path:hsa05034,Alcoholism
ROAA_HUMAN	Q99729	HNRNPAB	Heterogeneous nuclear ribonucleoprotein A/B	1.409944125	0.618472346	1.726396803	1.289182352	1.0142082355	1.5077895775	1.0142082355	1.5077895775	0.672645739587625	0.381455	0	1.48666666737987	0.381673	0	GO:0005737,cytoplasm;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0090575,RNA polymerase II transcription regulator complex	GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0001837,epithelial to mesenchymal transition;GO:0045893,positive regulation of transcription, DNA-templated;GO:0010468,regulation of gene expression	
HV169_HUMAN	P01742	IGHV1-69	Immunoglobulin heavy variable 1-69	0.663334835	0.197019846	0.622650418	1.46757318	0.4301773405	1.045111799	0.4301773405	1.045111799	0.411608921563807	0.146345	0	2.42949058587153	0.146675	0	GO:0009897,external side of plasma membrane;GO:0042571,immunoglobulin complex, circulating;GO:0005576,extracellular region;GO:0005886,plasma membrane;GO:0019814,immunoglobulin complex	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006956,complement activation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
SUCA_HUMAN	P53597	SUCLG1	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial	2.591273683	2.1157766	2.514295811	1.475118076	2.3535251415	1.9947069435	2.3535251415	1.9947069435	1.17988517018465	0.379318	0	0.84754010413022	0.379009	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0009361,succinate-CoA ligase complex (ADP-forming)	GO:0000166,nucleotide binding;GO:0003723,RNA binding;GO:0004775,succinate-CoA ligase (ADP-forming) activity;GO:0004776,succinate-CoA ligase (GDP-forming) activity	GO:0006099,tricarboxylic acid cycle	hsa:8802,path:hsa00020,Citrate cycle (TCA cycle);hsa:8802,path:hsa00640,Propanoate metabolism
GMFG_HUMAN	O60234	GMFG	Glia maturation factor gamma	0.11588837	1.42760908	0.066077127	0.123833519	0.771748725	0.094955323	0.771748725	0.094955323	8.12749302111268	0.026565	1	0.123039170553861	0.026293	-1	GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0034774,secretory granule lumen	GO:0003779,actin binding;GO:0071933,Arp2/3 complex binding;GO:0008047,enzyme activator activity;GO:0008083,growth factor activity;GO:0004860,protein kinase inhibitor activity	GO:0071846,actin filament debranching;GO:0034316,negative regulation of Arp2/3 complex-mediated actin nucleation;GO:0043312,neutrophil degranulation;GO:0006468,protein phosphorylation;GO:2000249,regulation of actin cytoskeleton reorganization	
MK13_HUMAN	O15264	MAPK13	Mitogen-activated protein kinase 13	2.55E-05	2.55E-05	0.064139329	2.55E-05	2.55e-005	0.0320824145	2.55e-005	0.0320824145	0.000794827957852112	0.000000	-1	1258.13390196078	0.000000	1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0004707,MAP kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0004672,protein kinase activity	GO:0007049,cell cycle;GO:0072740,cellular response to anisomycin;GO:0070301,cellular response to hydrogen peroxide;GO:0071347,cellular response to interleukin-1;GO:1903936,cellular response to sodium arsenite;GO:0072709,cellular response to sorbitol;GO:0034644,cellular response to UV;GO:0035556,intracellular signal transduction;GO:0018105,peptidyl-serine phosphorylation;GO:0050729,positive regulation of inflammatory response;GO:0032755,positive regulation of interleukin-6 production;GO:0006970,response to osmotic stress;GO:0051403,stress-activated MAPK cascade	hsa:5603,path:hsa04015,Rap1 signaling pathway;hsa:5603,path:hsa04010,MAPK signaling pathway;hsa:5603,path:hsa04370,VEGF signaling pathway;hsa:5603,path:hsa04668,TNF signaling pathway;hsa:5603,path:hsa04068,FoxO signaling pathway;hsa:5603,path:hsa04071,Sphingolipid signaling pathway;hsa:5603,path:hsa04114,Oocyte meiosis;hsa:5603,path:hsa04218,Cellular senescence;hsa:5603,path:hsa04550,Signaling pathways regulating pluripotency of stem cells;hsa:5603,path:hsa04611,Platelet activation;hsa:5603,path:hsa04620,Toll-like receptor signaling pathway;hsa:5603,path:hsa04621,NOD-like receptor signaling pathway;hsa:5603,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:5603,path:hsa04625,C-type lectin receptor signaling pathway;hsa:5603,path:hsa04660,T cell receptor signaling pathway;hsa:5603,path:hsa04658,Th1 and Th2 cell differentiation;hsa:5603,path:hsa04659,Th17 cell differentiation;hsa:5603,path:hsa04657,IL-17 signaling pathway;hsa:5603,path:hsa04664,Fc epsilon RI signaling pathway;hsa:5603,path:hsa04670,Leukocyte transendothelial migration;hsa:5603,path:hsa04912,GnRH signaling pathway;hsa:5603,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:5603,path:hsa04917,Prolactin signaling pathway;hsa:5603,path:hsa04926,Relaxin signaling pathway;hsa:5603,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:5603,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:5603,path:hsa04728,Dopaminergic synapse;hsa:5603,path:hsa04723,Retrograde endocannabinoid signaling;hsa:5603,path:hsa04722,Neurotrophin signaling pathway;hsa:5603,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:5603,path:hsa04380,Osteoclast differentiation;hsa:5603,path:hsa04714,Thermogenesis;hsa:5603,path:hsa05205,Proteoglycans in cancer;hsa:5603,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:5603,path:hsa05014,Amyotrophic lateral sclerosis (ALS);hsa:5603,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:5603,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:5603,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:5603,path:hsa05130,Pathogenic Escherichia coli infection;hsa:5603,path:hsa05132,Salmonella infection;hsa:5603,path:hsa05131,Shigellosis;hsa:5603,path:hsa05135,Yersinia infection;hsa:5603,path:hsa05133,Pertussis;hsa:5603,path:hsa05152,Tuberculosis;hsa:5603,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:5603,path:hsa05161,Hepatitis B;hsa:5603,path:hsa05163,Human cytomegalovirus infection;hsa:5603,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:5603,path:hsa05169,Epstein-Barr virus infection;hsa:5603,path:hsa05145,Toxoplasmosis;hsa:5603,path:hsa05140,Leishmaniasis;hsa:5603,path:hsa05142,Chagas disease (American trypanosomiasis);hsa:5603,path:hsa01522,Endocrine resistance
STT3A_HUMAN	P46977	STT3A	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A	4.966654126	4.826261187	7.035755545	5.034377891	4.8964576565	6.035066718	4.8964576565	6.035066718	0.811334469906684	0.493944	0	1.23253730377685	0.494041	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0008250,oligosaccharyltransferase complex;GO:0035000,oligosaccharyltransferase III complex	GO:0004579,dolichyl-diphosphooligosaccharide-protein glycotransferase activity;GO:0046872,metal ion binding	GO:0043686,co-translational protein modification;GO:0043687,post-translational protein modification;GO:0006487,protein N-linked glycosylation;GO:0018279,protein N-linked glycosylation via asparagine;GO:0019082,viral protein processing;GO:0006486,protein glycosylation	hsa:3703,path:hsa00510,N-Glycan biosynthesis;hsa:3703,path:hsa00513,Various types of N-glycan biosynthesis;hsa:3703,path:hsa04141,Protein processing in endoplasmic reticulum
SBP1_HUMAN	Q13228	SELENBP1	Methanethiol oxidase	3.785498798	26.13485278	39.04204857	43.0889755	14.960175789	41.065512035	14.960175789	41.065512035	0.364300237538728	0.107705	0	2.74498860268707	0.108011	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0001650,fibrillar center;GO:0016020,membrane;GO:0005730,nucleolus	GO:0018549,methanethiol oxidase activity;GO:0008430,selenium binding	GO:0015031,protein transport	hsa:8991,path:hsa00920,Sulfur metabolism
KAP0_HUMAN	P10644	PRKAR1A	cAMP-dependent protein kinase type I-alpha regulatory subunit	1.578033467	0.756977421	2.91277324	2.492686421	1.167505444	2.7027298305	1.167505444	2.7027298305	0.431972678447114	0.163928	0	2.3149612229988	0.164262	0	GO:0005952,cAMP-dependent protein kinase complex;GO:0005813,centrosome;GO:0097546,ciliary base;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0098978,glutamatergic synapse;GO:0016020,membrane;GO:0005771,multivesicular body;GO:0031594,neuromuscular junction;GO:0031588,nucleotide-activated protein kinase complex;GO:0044853,plasma membrane raft;GO:0032991,protein-containing complex;GO:0097224,sperm connecting piece;GO:0005886,plasma membrane	GO:0030552,cAMP binding;GO:0004862,cAMP-dependent protein kinase inhibitor activity;GO:0008603,cAMP-dependent protein kinase regulator activity;GO:0019904,protein domain specific binding;GO:0034236,protein kinase A catalytic subunit binding;GO:0031625,ubiquitin protein ligase binding	GO:0034199,activation of protein kinase A activity;GO:0007596,blood coagulation;GO:0060038,cardiac muscle cell proliferation;GO:0071377,cellular response to glucagon stimulus;GO:0007268,chemical synaptic transmission;GO:0007143,female meiotic nuclear division;GO:0035556,intracellular signal transduction;GO:0001707,mesoderm formation;GO:0046007,negative regulation of activated T cell proliferation;GO:2000480,negative regulation of cAMP-dependent protein kinase activity;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0045835,negative regulation of meiotic nuclear division;GO:0043949,regulation of cAMP-mediated signaling;GO:0010738,regulation of protein kinase A signaling;GO:0006357,regulation of transcription by RNA polymerase II;GO:0003091,renal water homeostasis;GO:0045214,sarcomere organization	hsa:5573,path:hsa04910,Insulin signaling pathway
GAL3B_HUMAN	A0A0B4J2D5	GATD3B	Glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial	0.29092114	0.31548308	1.265951312	0.746281253	0.30320211	1.0061162825	0.30320211	1.0061162825	0.301358913749614	0.063170	0	3.3183023775791	0.063417	0	GO:0005739,mitochondrion			
H1BP3_HUMAN	Q53T59	HS1BP3	HCLS1-binding protein 3	0.348598298	0.512115358	0.510677514	0.413738792	0.430356828	0.462208153	0.430356828	0.462208153	0.931088785878686	0.457130	0	1.07401143174148	0.456984	0	GO:0005783,endoplasmic reticulum;GO:0005739,mitochondrion	GO:0035091,phosphatidylinositol binding	GO:0042981,regulation of apoptotic process	
ODPX_HUMAN	O00330	PDHX	Pyruvate dehydrogenase protein X component, mitochondrial	0.298070477	0.080672539	0.195243154	0.173670748	0.189371508	0.184456951	0.189371508	0.184456951	1.02664338195637	0.424650	0	0.974048065350993	0.424435	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0045254,pyruvate dehydrogenase complex	GO:0016746,transferase activity, transferring acyl groups	GO:0061732,mitochondrial acetyl-CoA biosynthetic process from pyruvate;GO:0006090,pyruvate metabolic process	hsa:8050,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:8050,path:hsa00020,Citrate cycle (TCA cycle);hsa:8050,path:hsa00620,Pyruvate metabolism
MTNB_HUMAN	Q96GX9	APIP	Methylthioribulose-1-phosphate dehydratase	0.158173924	0.444899885	0.946354436	2.221000368	0.3015369045	1.583677402	0.3015369045	1.583677402	0.190402984925588	0.012861	-1	5.2520185037583	0.012954	1	GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0042802,identical protein binding;GO:0046570,methylthioribulose 1-phosphate dehydratase activity;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0006915,apoptotic process;GO:0019509,L-methionine salvage from methylthioadenosine;GO:0019284,L-methionine salvage from S-adenosylmethionine;GO:0043066,negative regulation of apoptotic process;GO:0051289,protein homotetramerization;GO:0070269,pyroptosis;GO:0070372,regulation of ERK1 and ERK2 cascade	hsa:51074,path:hsa00270,Cysteine and methionine metabolism
NNTM_HUMAN	Q13423	NNT	NAD(P) transhydrogenase, mitochondrial	11.34077976	9.68873108	12.74797915	8.953109668	10.51475542	10.850544409	10.51475542	10.850544409	0.969053258864921	0.443796	0	1.03193502612161	0.443621	0	GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005746,mitochondrial respirasome;GO:0005739,mitochondrion	GO:0051287,NAD binding;GO:0003957,NAD(P)+ transhydrogenase (B-specific) activity;GO:0008746,NAD(P)+ transhydrogenase activity;GO:0050661,NADP binding;GO:0016491,oxidoreductase activity	GO:0045454,cell redox homeostasis;GO:0098869,cellular oxidant detoxification;GO:0006740,NADPH regeneration;GO:0043066,negative regulation of apoptotic process;GO:0001933,negative regulation of protein phosphorylation;GO:0032364,oxygen homeostasis;GO:1903285,positive regulation of hydrogen peroxide catabolic process;GO:0010918,positive regulation of mitochondrial membrane potential;GO:1902600,proton transmembrane transport;GO:0072593,reactive oxygen species metabolic process;GO:0033273,response to vitamin;GO:0006099,tricarboxylic acid cycle	hsa:23530,path:hsa00760,Nicotinate and nicotinamide metabolism
KV240_HUMAN	A0A087WW87	IGKV2-40	Immunoglobulin kappa variable 2-40	7.228318682	9.719567356	6.710817948	11.63055044	8.473943019	9.170684194	8.473943019	9.170684194	0.924025169740787	0.459676	0	1.08222160255713	0.459537	0	GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region	GO:0003823,antigen binding	GO:0002250,adaptive immune response;GO:0006955,immune response;GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response	
OAS2_HUMAN	P29728	OAS2	2'-5'-oligoadenylate synthase 2	2.177877882	2.880274383	2.967792947	3.30730001	2.5290761325	3.1375464785	2.5290761325	3.1375464785	0.806068101247412	0.489974	0	1.24058996808393	0.490076	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm	GO:0001730,2'-5'-oligoadenylate synthetase activity;GO:0005524,ATP binding;GO:0003725,double-stranded RNA binding;GO:0046872,metal ion binding	GO:0042742,defense response to bacterium;GO:0051607,defense response to virus;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0070106,interleukin-27-mediated signaling pathway;GO:0045071,negative regulation of viral genome replication;GO:0006139,nucleobase-containing compound metabolic process;GO:0032728,positive regulation of interferon-beta production;GO:0032760,positive regulation of tumor necrosis factor production;GO:1903487,regulation of lactation;GO:0060700,regulation of ribonuclease activity;GO:0009615,response to virus;GO:0006401,RNA catabolic process;GO:0060337,type I interferon signaling pathway;GO:0045087,innate immune response	hsa:4939,path:hsa04621,NOD-like receptor signaling pathway;hsa:4939,path:hsa05162,Measles;hsa:4939,path:hsa05164,Influenza A;hsa:4939,path:hsa05160,Hepatitis C;hsa:4939,path:hsa05168,Herpes simplex virus 1 infection;hsa:4939,path:hsa05169,Epstein-Barr virus infection
KAD3_HUMAN	Q9UIJ7	AK3	GTP:AMP phosphotransferase AK3, mitochondrial	1.02995266	1.188315738	1.47042883	1.513668209	1.109134199	1.4920485195	1.109134199	1.4920485195	0.743363358834793	0.440819	0	1.34523714158777	0.440976	0	GO:0005737,cytoplasm;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0005525,GTP binding;GO:0046899,nucleoside triphosphate adenylate kinase activity	GO:0006172,ADP biosynthetic process;GO:0046033,AMP metabolic process;GO:0007596,blood coagulation;GO:0046039,GTP metabolic process;GO:0046041,ITP metabolic process;GO:0046940,nucleoside monophosphate phosphorylation;GO:0009142,nucleoside triphosphate biosynthetic process;GO:0046051,UTP metabolic process	hsa:50808,path:hsa00230,Purine metabolism
PURA_HUMAN	Q00577	PURA	Transcriptional activator protein Pur-alpha	0.721613325	0.274802741	1.069925033	1.19228612	0.498208033	1.1311055765	0.498208033	1.1311055765	0.44046112348028	0.171385	0	2.27034793013865	0.171721	0	GO:0000781,chromosome, telomeric region;GO:0032839,dendrite cytoplasm;GO:0098978,glutamatergic synapse;GO:0043025,neuronal cell body;GO:0005634,nucleus;GO:0098794,postsynapse	GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003691,double-stranded telomeric DNA binding;GO:0032422,purine-rich negative regulatory element binding;GO:0003723,RNA binding;GO:0000977,RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0003697,single-stranded DNA binding;GO:0046332,SMAD binding;GO:0008134,transcription factor binding;GO:0000900,translation repressor activity, mRNA regulatory element binding	GO:0030154,cell differentiation;GO:0098963,dendritic transport of messenger ribonucleoprotein complex;GO:0006270,DNA replication initiation;GO:0006268,DNA unwinding involved in DNA replication;GO:0050673,epithelial cell proliferation;GO:0046651,lymphocyte proliferation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0007399,nervous system development;GO:0008284,positive regulation of cell population proliferation;GO:0006357,regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0042127,regulation of cell population proliferation	
TES_HUMAN	Q9UGI8	TES	Testin	0.991814991	0.699746263	0.912606343	1.412862357	0.845780627	1.16273435	0.845780627	1.16273435	0.727406588615878	0.427770	0	1.37474696497157	0.427941	0	GO:0030054,cell junction;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0005737,cytoplasm	GO:0045296,cadherin binding;GO:0003723,RNA binding;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0008285,negative regulation of cell population proliferation;GO:0042127,regulation of cell population proliferation	
CBX3_HUMAN	Q13185	CBX3	Chromobox protein homolog 3	1.399281137	2.664829571	0.286308674	0.007457763	2.032055354	0.1468832185	2.032055354	0.1468832185	13.8344963757722	0.008605	1	0.0722830794007986	0.008479	-1	GO:0000785,chromatin;GO:0000775,chromosome, centromeric region;GO:0000781,chromosome, telomeric region;GO:0000779,condensed chromosome, centromeric region;GO:0000791,euchromatin;GO:0000792,heterochromatin;GO:0005635,nuclear envelope;GO:0005637,nuclear inner membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005721,pericentric heterochromatin;GO:0090575,RNA polymerase II transcription regulator complex;GO:0035985,senescence-associated heterochromatin focus;GO:0090734,site of DNA damage;GO:0005819,spindle	GO:0019899,enzyme binding;GO:1990226,histone methyltransferase binding;GO:0042802,identical protein binding;GO:0019904,protein domain specific binding;GO:0008134,transcription factor binding	GO:0071549,cellular response to dexamethasone stimulus;GO:0006974,cellular response to DNA damage stimulus;GO:0006338,chromatin remodeling;GO:0070317,negative regulation of G0 to G1 transition;GO:0045892,negative regulation of transcription, DNA-templated;GO:0048511,rhythmic process	hsa:11335,path:hsa05131,Shigellosis
SYJ2B_HUMAN	P57105	SYNJ2BP	Synaptojanin-2-binding protein	0.898931063	1.757539273	0.09647468	0.17061615	1.328235168	0.133545415	1.328235168	0.133545415	9.9459436177573	0.017687	1	0.100543501796513	0.017478	-1	GO:0016323,basolateral plasma membrane;GO:0030054,cell junction;GO:0031307,integral component of mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0031594,neuromuscular junction;GO:0043005,neuron projection;GO:0098839,postsynaptic density membrane;GO:0005743,mitochondrial inner membrane;GO:0016021,integral component of membrane	GO:0008022,protein C-terminus binding	GO:0098609,cell-cell adhesion;GO:0007268,chemical synaptic transmission;GO:0045197,establishment or maintenance of epithelial cell apical/basal polarity;GO:0016525,negative regulation of angiogenesis;GO:0010596,negative regulation of endothelial cell migration;GO:0001937,negative regulation of endothelial cell proliferation;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:1903671,negative regulation of sprouting angiogenesis;GO:0043113,receptor clustering;GO:0097120,receptor localization to synapse;GO:0008593,regulation of Notch signaling pathway;GO:0048312,intracellular distribution of mitochondria	
EF1A2_HUMAN	Q05639	EEF1A2	Elongation factor 1-alpha 2	0.848370696	2.55E-05	0.032960978	0.003665665	0.424198098	0.0183133215	0.424198098	0.0183133215	23.1633621459657	0.002427	1	0.0431716256775861	0.002379	-1	GO:0005737,cytoplasm;GO:0098574,cytoplasmic side of lysosomal membrane;GO:0005853,eukaryotic translation elongation factor 1 complex;GO:0043025,neuronal cell body;GO:0045202,synapse	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0019901,protein kinase binding;GO:0003746,translation elongation factor activity;GO:0008135,translation factor activity, RNA binding	GO:0043065,positive regulation of apoptotic process;GO:0090218,positive regulation of lipid kinase activity;GO:1904714,regulation of chaperone-mediated autophagy;GO:0051602,response to electrical stimulus;GO:0010035,response to inorganic substance;GO:0006412,translation;GO:0006414,translational elongation	hsa:1917,path:hsa03013,RNA transport;hsa:1917,path:hsa05134,Legionellosis;hsa:1917,path:hsa05140,Leishmaniasis
UBP5_HUMAN	P45974	USP5	Ubiquitin carboxyl-terminal hydrolase 5	3.3022035	2.734255567	5.167482001	5.500794819	3.0182295335	5.33413841	3.0182295335	5.33413841	0.565832624035716	0.285723	0	1.76730707548754	0.286021	0	GO:0005829,cytosol;GO:0005764,lysosome;GO:0005634,nucleus	GO:0004197,cysteine-type endopeptidase activity;GO:0004843,thiol-dependent deubiquitinase;GO:0043130,ubiquitin binding;GO:0008270,zinc ion binding	GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0071108,protein K48-linked deubiquitination;GO:0016567,protein ubiquitination;GO:0006511,ubiquitin-dependent protein catabolic process	
TPPC3_HUMAN	O43617	TRAPPC3	Trafficking protein particle complex subunit 3	0.65399359	3.371915738	0.117927243	0.166307646	2.012954664	0.1421174445	2.012954664	0.1421174445	14.1640223765774	0.008152	1	0.0706014134553802	0.008031	-1	GO:0033106,cis-Golgi network membrane;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0030008,TRAPP complex;GO:0000139,Golgi membrane		GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006891,intra-Golgi vesicle-mediated transport;GO:0048193,Golgi vesicle transport	
GCP2_HUMAN	Q9BSJ2	TUBGCP2	Gamma-tubulin complex component 2	0.154433157	0.07796796	0.183927466	0.062607795	0.1162005585	0.1232676305	0.1162005585	0.1232676305	0.942668874453622	0.453000	0	1.06081788324623	0.452846	0	GO:0005813,centrosome;GO:0005881,cytoplasmic microtubule;GO:0005829,cytosol;GO:0000923,equatorial microtubule organizing center;GO:0000930,gamma-tubulin complex;GO:0008275,gamma-tubulin small complex;GO:0016020,membrane;GO:0005815,microtubule organizing center;GO:0005654,nucleoplasm;GO:0000922,spindle pole;GO:0005737,cytoplasm;GO:0005874,microtubule	GO:0043015,gamma-tubulin binding	GO:0007420,brain development;GO:0031122,cytoplasmic microtubule organization;GO:0051321,meiotic cell cycle;GO:0007020,microtubule nucleation;GO:0000278,mitotic cell cycle;GO:0001764,neuron migration;GO:0065003,protein-containing complex assembly;GO:0051225,spindle assembly	
LARP4_HUMAN	Q71RC2	LARP4	La-related protein 4	0.018725809	0.015116924	0.049124681	2.55E-05	0.0169213665	0.0245750905	0.0169213665	0.0245750905	0.688557647427585	0.395145	0	1.45231122439195	0.395351	0	GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0016020,membrane	GO:0003730,mRNA 3'-UTR binding;GO:0008143,poly(A) binding;GO:0003723,RNA binding	GO:0007010,cytoskeleton organization;GO:0045727,positive regulation of translation;GO:0010608,posttranscriptional regulation of gene expression;GO:0022604,regulation of cell morphogenesis;GO:0006412,translation	
AKT2_HUMAN	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.013029744	0.024146592	0.048881145	2.55E-05	0.018588168	0.0244533225	0.018588168	0.0244533225	0.760148973621069	0.454314	0	1.31553160591189	0.454456	0	GO:0005938,cell cortex;GO:0005829,cytosol;GO:0005769,early endosome;GO:0043231,intracellular membrane-bounded organelle;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0032587,ruffle membrane	GO:0005524,ATP binding;GO:0046872,metal ion binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0004672,protein kinase activity	GO:0090630,activation of GTPase activity;GO:0008643,carbohydrate transport;GO:0006464,cellular protein modification process;GO:0071486,cellular response to high light intensity;GO:0032869,cellular response to insulin stimulus;GO:0045444,fat cell differentiation;GO:0006006,glucose metabolic process;GO:0005978,glycogen biosynthetic process;GO:0008286,insulin receptor signaling pathway;GO:0065002,intracellular protein transmembrane transport;GO:0035556,intracellular signal transduction;GO:0060644,mammary gland epithelial cell differentiation;GO:0043066,negative regulation of apoptotic process;GO:0010748,negative regulation of long-chain fatty acid import across plasma membrane;GO:0018105,peptidyl-serine phosphorylation;GO:0032287,peripheral nervous system myelin maintenance;GO:0030335,positive regulation of cell migration;GO:2000147,positive regulation of cell motility;GO:0008284,positive regulation of cell population proliferation;GO:0032000,positive regulation of fatty acid beta-oxidation;GO:0046326,positive regulation of glucose import;GO:0010907,positive regulation of glucose metabolic process;GO:0045725,positive regulation of glycogen biosynthetic process;GO:0010918,positive regulation of mitochondrial membrane potential;GO:0051897,positive regulation of protein kinase B signaling;GO:0001934,positive regulation of protein phosphorylation;GO:0090314,positive regulation of protein targeting to membrane;GO:0031340,positive regulation of vesicle fusion;GO:0072659,protein localization to plasma membrane;GO:0071156,regulation of cell cycle arrest;GO:0030334,regulation of cell migration;GO:0006417,regulation of translation;GO:0097473,retinal rod cell apoptotic process;GO:0007165,signal transduction;GO:0043491,protein kinase B signaling	hsa:208,path:hsa04014,Ras signaling pathway;hsa:208,path:hsa04015,Rap1 signaling pathway;hsa:208,path:hsa04010,MAPK signaling pathway;hsa:208,path:hsa04012,ErbB signaling pathway;hsa:208,path:hsa04370,VEGF signaling pathway;hsa:208,path:hsa04371,Apelin signaling pathway;hsa:208,path:hsa04630,Jak-STAT signaling pathway;hsa:208,path:hsa04668,TNF signaling pathway;hsa:208,path:hsa04066,HIF-1 signaling pathway;hsa:208,path:hsa04068,FoxO signaling pathway;hsa:208,path:hsa04072,Phospholipase D signaling pathway;hsa:208,path:hsa04071,Sphingolipid signaling pathway;hsa:208,path:hsa04024,cAMP signaling pathway;hsa:208,path:hsa04022,cGMP-PKG signaling pathway;hsa:208,path:hsa04151,PI3K-Akt signaling pathway;hsa:208,path:hsa04152,AMPK signaling pathway;hsa:208,path:hsa04150,mTOR signaling pathway;hsa:208,path:hsa04140,Autophagy - animal;hsa:208,path:hsa04210,Apoptosis;hsa:208,path:hsa04218,Cellular senescence;hsa:208,path:hsa04510,Focal adhesion;hsa:208,path:hsa04550,Signaling pathways regulating pluripotency of stem cells;hsa:208,path:hsa04611,Platelet activation;hsa:208,path:hsa04620,Toll-like receptor signaling pathway;hsa:208,path:hsa04625,C-type lectin receptor signaling pathway;hsa:208,path:hsa04660,T cell receptor signaling pathway;hsa:208,path:hsa04662,B cell receptor signaling pathway;hsa:208,path:hsa04664,Fc epsilon RI signaling pathway;hsa:208,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:208,path:hsa04062,Chemokine signaling pathway;hsa:208,path:hsa04910,Insulin signaling pathway;hsa:208,path:hsa04922,Glucagon signaling pathway;hsa:208,path:hsa04923,Regulation of lipolysis in adipocytes;hsa:208,path:hsa04920,Adipocytokine signaling pathway;hsa:208,path:hsa04929,GnRH secretion;hsa:208,path:hsa04915,Estrogen signaling pathway;hsa:208,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:208,path:hsa04917,Prolactin signaling pathway;hsa:208,path:hsa04926,Relaxin signaling pathway;hsa:208,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:208,path:hsa04919,Thyroid hormone signaling pathway;hsa:208,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:208,path:hsa04973,Carbohydrate digestion and absorption;hsa:208,path:hsa04725,Cholinergic synapse;hsa:208,path:hsa04728,Dopaminergic synapse;hsa:208,path:hsa04722,Neurotrophin signaling pathway;hsa:208,path:hsa04380,Osteoclast differentiation;hsa:208,path:hsa04211,Longevity regulating pathway;hsa:208,path:hsa04213,Longevity regulating pathway - multiple species;hsa:208,path:hsa05200,Pathways in cancer;hsa:208,path:hsa05205,Proteoglycans in cancer;hsa:208,path:hsa05230,Central carbon metabolism in cancer;hsa:208,path:hsa05231,Choline metabolism in cancer;hsa:208,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:208,path:hsa05210,Colorectal cancer;hsa:208,path:hsa05212,Pancreatic cancer;hsa:208,path:hsa05225,Hepatocellular carcinoma;hsa:208,path:hsa05226,Gastric cancer;hsa:208,path:hsa05214,Glioma;hsa:208,path:hsa05221,Acute myeloid leukemia;hsa:208,path:hsa05220,Chronic myeloid leukemia;hsa:208,path:hsa05218,Melanoma;hsa:208,path:hsa05211,Renal cell carcinoma;hsa:208,path:hsa05215,Prostate cancer;hsa:208,path:hsa05213,Endometrial cancer;hsa:208,path:hsa05224,Breast cancer;hsa:208,path:hsa05222,Small cell lung cancer;hsa:208,path:hsa05223,Non-small cell lung cancer;hsa:208,path:hsa05017,Spinocerebellar ataxia;hsa:208,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:208,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:208,path:hsa04931,Insulin resistance;hsa:208,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:208,path:hsa05132,Salmonella infection;hsa:208,path:hsa05131,Shigellosis;hsa:208,path:hsa05135,Yersinia infection;hsa:208,path:hsa05152,Tuberculosis;hsa:208,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:208,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:208,path:hsa05162,Measles;hsa:208,path:hsa05164,Influenza A;hsa:208,path:hsa05161,Hepatitis B;hsa:208,path:hsa05160,Hepatitis C;hsa:208,path:hsa05168,Herpes simplex virus 1 infection;hsa:208,path:hsa05163,Human cytomegalovirus infection;hsa:208,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:208,path:hsa05169,Epstein-Barr virus infection;hsa:208,path:hsa05165,Human papillomavirus infection;hsa:208,path:hsa05145,Toxoplasmosis;hsa:208,path:hsa05142,Chagas disease (American trypanosomiasis);hsa:208,path:hsa01521,EGFR tyrosine kinase inhibitor resistance;hsa:208,path:hsa01524,Platinum drug resistance;hsa:208,path:hsa01522,Endocrine resistance
GBF1_HUMAN	Q92538	GBF1	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	0.907842496	0.721013236	1.140274099	0.717145876	0.814427866	0.9287099875	0.814427866	0.9287099875	0.876945307966767	0.477204	0	1.1403219686739	0.477103	0	GO:0031252,cell leading edge;GO:0005801,cis-Golgi network;GO:0005829,cytosol;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005811,lipid droplet;GO:0016020,membrane;GO:0005802,trans-Golgi network;GO:0005788,endoplasmic reticulum lumen;GO:0005795,Golgi stack;GO:0005739,mitochondrion;GO:0005777,peroxisome	GO:0005085,guanyl-nucleotide exchange factor activity;GO:0005547,phosphatidylinositol-3,4,5-trisphosphate binding;GO:0080025,phosphatidylinositol-3,5-bisphosphate binding	GO:0002263,cell activation involved in immune response;GO:0098586,cellular response to virus;GO:0060271,cilium assembly;GO:0048205,COPI coating of Golgi vesicle;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0097111,endoplasmic reticulum-Golgi intermediate compartment organization;GO:0061162,establishment of monopolar cell polarity;GO:0090166,Golgi disassembly;GO:0007030,Golgi organization;GO:0006895,Golgi to endosome transport;GO:0030593,neutrophil chemotaxis;GO:0006892,post-Golgi vesicle-mediated transport;GO:0070973,protein localization to endoplasmic reticulum exit site;GO:1903420,protein localization to endoplasmic reticulum tubular network;GO:0034067,protein localization to Golgi apparatus;GO:0015031,protein transport;GO:1903409,reactive oxygen species biosynthetic process;GO:0032012,regulation of ARF protein signal transduction;GO:0007346,regulation of mitotic cell cycle;GO:2000008,regulation of protein localization to cell surface;GO:0042147,retrograde transport, endosome to Golgi;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0016032,viral process	hsa:8729,path:hsa04144,Endocytosis
CPNS1_HUMAN	P04632	CAPNS1	Calpain small subunit 1	1.812991802	1.791473866	0.595013362	1.204627689	1.802232834	0.8998205255	1.802232834	0.8998205255	2.00288033327375	0.225638	0	0.499280952230171	0.225095	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0005737,cytoplasm	GO:0005509,calcium ion binding;GO:0004198,calcium-dependent cysteine-type endopeptidase activity;GO:0046872,metal ion binding	GO:0070268,cornification;GO:0022617,extracellular matrix disassembly;GO:0008284,positive regulation of cell population proliferation;GO:0016241,regulation of macroautophagy	hsa:826,path:hsa05131,Shigellosis
1433Z_HUMAN	P63104	YWHAZ	14-3-3 protein zeta/delta	28.56784927	33.80834415	28.05353123	24.97954298	31.18809671	26.516537105	31.18809671	26.516537105	1.17617532736275	0.380328	0	0.850213379532643	0.380022	0	GO:0072562,blood microparticle;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0042470,melanosome;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0031982,vesicle;GO:0098686,hippocampal mossy fiber to CA3 synapse	GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0044325,ion channel binding;GO:0019901,protein kinase binding;GO:0003723,RNA binding;GO:0008134,transcription factor binding;GO:0031625,ubiquitin protein ligase binding;GO:0016301,kinase activity;GO:0019904,protein domain specific binding	GO:0002250,adaptive immune response;GO:0019221,cytokine-mediated signaling pathway;GO:0051683,establishment of Golgi localization;GO:0090168,Golgi reassembly;GO:0043066,negative regulation of apoptotic process;GO:0030168,platelet activation;GO:1900740,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0006468,protein phosphorylation;GO:0070372,regulation of ERK1 and ERK2 cascade;GO:0043488,regulation of mRNA stability;GO:0090128,regulation of synapse maturation;GO:0007165,signal transduction;GO:0001525,angiogenesis;GO:0070371,ERK1 and ERK2 cascade;GO:0030324,lung development;GO:0006605,protein targeting;GO:0010941,regulation of cell death;GO:0003016,respiratory system process;GO:0008039,synaptic target recognition;GO:0035148,tube formation	hsa:7534,path:hsa04390,Hippo signaling pathway;hsa:7534,path:hsa04151,PI3K-Akt signaling pathway;hsa:7534,path:hsa04110,Cell cycle;hsa:7534,path:hsa04114,Oocyte meiosis;hsa:7534,path:hsa05203,Viral carcinogenesis;hsa:7534,path:hsa05161,Hepatitis B;hsa:7534,path:hsa05160,Hepatitis C
LAMA4_HUMAN	Q16363	LAMA4	Laminin subunit alpha-4	2.200683402	1.234094523	3.128588834	7.128280028	1.7173889625	5.128434431	1.7173889625	5.128434431	0.334875874032599	0.085730	0	2.9861810824349	0.086012	0	GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0016020,membrane;GO:0031594,neuromuscular junction;GO:0043083,synaptic cleft	GO:0005201,extracellular matrix structural constituent;GO:0005102,signaling receptor binding	GO:0007155,cell adhesion;GO:0030198,extracellular matrix organization;GO:0120163,negative regulation of cold-induced thermogenesis;GO:0030155,regulation of cell adhesion;GO:0030334,regulation of cell migration;GO:0045995,regulation of embryonic development;GO:0001568,blood vessel development;GO:0050873,brown fat cell differentiation	hsa:3910,path:hsa04151,PI3K-Akt signaling pathway;hsa:3910,path:hsa04512,ECM-receptor interaction;hsa:3910,path:hsa04510,Focal adhesion;hsa:3910,path:hsa05200,Pathways in cancer;hsa:3910,path:hsa05222,Small cell lung cancer;hsa:3910,path:hsa05165,Human papillomavirus infection;hsa:3910,path:hsa05146,Amoebiasis;hsa:3910,path:hsa05145,Toxoplasmosis;hsa:3910,path:hsa05143,African trypanosomiasis
MTPN_HUMAN	P58546	MTPN	Myotrophin	0.029776861	0.034585525	2.55E-05	0.485555553	0.032181193	0.2427905265	0.032181193	0.2427905265	0.132547152740739	0.002685	-1	7.54448495740975	0.002714	1	GO:0030424,axon;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0008290,F-actin capping protein complex;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm	GO:0043565,sequence-specific DNA binding	GO:0006584,catecholamine metabolic process;GO:0071260,cellular response to mechanical stimulus;GO:0021707,cerebellar granule cell differentiation;GO:0030182,neuron differentiation;GO:0010613,positive regulation of cardiac muscle hypertrophy;GO:0030307,positive regulation of cell growth;GO:0010557,positive regulation of macromolecule biosynthetic process;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0051247,positive regulation of protein metabolic process;GO:2000812,regulation of barbed-end actin filament capping;GO:0008361,regulation of cell size;GO:0016202,regulation of striated muscle tissue development;GO:0006417,regulation of translation;GO:0043403,skeletal muscle tissue regeneration;GO:0051146,striated muscle cell differentiation	
SYCM_HUMAN	Q9HA77	CARS2	Probable cysteine--tRNA ligase, mitochondrial	0.678357858	0.219166959	0.192941615	0.265612674	0.4487624085	0.2292771445	0.4487624085	0.2292771445	1.9572923828873	0.231510	0	0.510909871587428	0.230972	0	GO:0005737,cytoplasm;GO:0005759,mitochondrial matrix	GO:0005524,ATP binding;GO:0004817,cysteine-tRNA ligase activity;GO:0046872,metal ion binding;GO:0016874,ligase activity;GO:0004812,aminoacyl-tRNA ligase activity	GO:0006423,cysteinyl-tRNA aminoacylation;GO:0006418,tRNA aminoacylation for protein translation	hsa:79587,path:hsa00970,Aminoacyl-tRNA biosynthesis
ALDOA_HUMAN	P04075	ALDOA	Fructose-bisphosphate aldolase A	63.15350599	82.39258266	64.60272419	55.93010198	72.773044325	60.266413085	72.773044325	60.266413085	1.20752240924577	0.371914	0	0.828141980921588	0.371591	0	GO:0015629,actin cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0031674,I band;GO:0031430,M band;GO:0016020,membrane;GO:0005634,nucleus;GO:0031093,platelet alpha granule lumen;GO:0034774,secretory granule lumen;GO:0061827,sperm head;GO:1904724,tertiary granule lumen	GO:0003779,actin binding;GO:0045296,cadherin binding;GO:0008092,cytoskeletal protein binding;GO:0070061,fructose binding;GO:0004332,fructose-bisphosphate aldolase activity;GO:0042802,identical protein binding;GO:0003723,RNA binding;GO:0015631,tubulin binding	GO:0007015,actin filament organization;GO:0006754,ATP biosynthetic process;GO:0007339,binding of sperm to zona pellucida;GO:0061621,canonical glycolysis;GO:0030388,fructose 1,6-bisphosphate metabolic process;GO:0006000,fructose metabolic process;GO:0006094,gluconeogenesis;GO:0006096,glycolytic process;GO:0046716,muscle cell cellular homeostasis;GO:0043312,neutrophil degranulation;GO:0002576,platelet degranulation;GO:0051289,protein homotetramerization;GO:0008360,regulation of cell shape;GO:0006941,striated muscle contraction	hsa:226,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:226,path:hsa00030,Pentose phosphate pathway;hsa:226,path:hsa00051,Fructose and mannose metabolism;hsa:226,path:hsa04066,HIF-1 signaling pathway
TLN2_HUMAN	Q9Y4G6	TLN2	Talin-2	1.09970032	1.31227733	1.022225841	1.785314621	1.205988825	1.403770231	1.205988825	1.403770231	0.85910699512476	0.484106	0	1.16399936873379	0.484021	0	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0005925,focal adhesion;GO:0005886,plasma membrane;GO:0001726,ruffle;GO:0045202,synapse;GO:0005856,cytoskeleton	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0005178,integrin binding;GO:0005200,structural constituent of cytoskeleton;GO:0005198,structural molecule activity	GO:0007155,cell adhesion;GO:0098609,cell-cell adhesion;GO:0007043,cell-cell junction assembly	hsa:83660,path:hsa04015,Rap1 signaling pathway;hsa:83660,path:hsa04510,Focal adhesion;hsa:83660,path:hsa04611,Platelet activation;hsa:83660,path:hsa05131,Shigellosis;hsa:83660,path:hsa05166,Human T-cell leukemia virus 1 infection
YKT6_HUMAN	O15498	YKT6	Synaptobrevin homolog YKT6	2.570834255	6.298400413	0.441003967	0.351164585	4.434617334	0.396084276	4.434617334	0.396084276	11.196145877803	0.013768	1	0.0893164496885088	0.013591	-1	GO:0097440,apical dendrite;GO:0097441,basal dendrite;GO:0005737,cytoplasm;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005768,endosome;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005887,integral component of plasma membrane;GO:0005739,mitochondrion;GO:0043025,neuronal cell body;GO:0031201,SNARE complex;GO:0030133,transport vesicle	GO:0045296,cadherin binding;GO:0019706,protein-cysteine S-palmitoyltransferase activity;GO:0005484,SNAP receptor activity	GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0015031,protein transport;GO:0042147,retrograde transport, endosome to Golgi;GO:0006904,vesicle docking involved in exocytosis;GO:0006903,vesicle targeting	hsa:10652,path:hsa04130,SNARE interactions in vesicular transport
DJB11_HUMAN	Q9UBS4	DNAJB11	DnaJ homolog subfamily B member 11	1.064462978	0.76756064	1.541248786	0.991061318	0.916011809	1.266155052	0.916011809	1.266155052	0.723459427463549	0.424510	0	1.38224752078496	0.424684	0	GO:0101031,chaperone complex;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0016020,membrane	GO:0051787,misfolded protein binding;GO:0051082,unfolded protein binding	GO:0036498,IRE1-mediated unfolded protein response;GO:0032781,positive regulation of ATPase activity;GO:0006457,protein folding;GO:0051604,protein maturation	hsa:51726,path:hsa04141,Protein processing in endoplasmic reticulum
VATA_HUMAN	P38606	ATP6V1A	V-type proton ATPase catalytic subunit A	12.28997234	12.24702997	12.94207057	13.70661006	12.268501155	13.324340315	12.268501155	13.324340315	0.920758616558947	0.460861	0	1.08606097408808	0.460724	0	GO:0016324,apical plasma membrane;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0005765,lysosomal membrane;GO:0005902,microvillus;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0016469,proton-transporting two-sector ATPase complex;GO:0033180,proton-transporting V-type ATPase, V1 domain	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0046933,proton-transporting ATP synthase activity, rotational mechanism;GO:0046961,proton-transporting ATPase activity, rotational mechanism	GO:0006879,cellular iron ion homeostasis;GO:0034198,cellular response to amino acid starvation;GO:0036295,cellular response to increased oxygen levels;GO:0008286,insulin receptor signaling pathway;GO:0034220,ion transmembrane transport;GO:0090383,phagosome acidification;GO:1902600,proton transmembrane transport;GO:0016241,regulation of macroautophagy;GO:0033572,transferrin transport;GO:0046034,ATP metabolic process	hsa:523,path:hsa00190,Oxidative phosphorylation;hsa:523,path:hsa04150,mTOR signaling pathway;hsa:523,path:hsa04145,Phagosome;hsa:523,path:hsa04966,Collecting duct acid secretion;hsa:523,path:hsa04721,Synaptic vesicle cycle;hsa:523,path:hsa05323,Rheumatoid arthritis;hsa:523,path:hsa05110,Vibrio cholerae infection;hsa:523,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:523,path:hsa05165,Human papillomavirus infection
H2AV_HUMAN	Q71UI9	H2AZ2	Histone H2A.V	1.496955273	2.351179167	0.488392501	0.786214475	1.92406722	0.637303488	1.92406722	0.637303488	3.01907530121662	0.135847	0	0.331227246831844	0.135285	0	GO:0070062,extracellular exosome;GO:0000786,nucleosome;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0046982,protein heterodimerization activity	GO:0006342,chromatin silencing	hsa:94239,path:hsa04217,Necroptosis;hsa:94239,path:hsa05322,Systemic lupus erythematosus;hsa:94239,path:hsa05034,Alcoholism
EPS8_HUMAN	Q12929	EPS8	Epidermal growth factor receptor kinase substrate 8	0.069869922	0.054613212	0.150804464	0.220714317	0.062241567	0.1857593905	0.062241567	0.1857593905	0.335065521223273	0.085865	0	2.98449090300056	0.086147	0	GO:0005938,cell cortex;GO:0070062,extracellular exosome;GO:0030426,growth cone;GO:0005886,plasma membrane;GO:0032587,ruffle membrane;GO:0032420,stereocilium;GO:0045202,synapse;GO:0031982,vesicle;GO:0005903,brush border;GO:0098978,glutamatergic synapse;GO:0017146,NMDA selective glutamate receptor complex;GO:0014069,postsynaptic density;GO:0032426,stereocilium tip;GO:0005737,cytoplasm	GO:0003779,actin binding;GO:0035591,signaling adaptor activity;GO:0031267,small GTPase binding	GO:0051764,actin crosslink formation;GO:0051017,actin filament bundle assembly;GO:0070358,actin polymerization-dependent cell motility;GO:0051016,barbed-end actin filament capping;GO:0036336,dendritic cell migration;GO:0010458,exit from mitosis;GO:1900029,positive regulation of ruffle assembly;GO:0016601,Rac protein signal transduction;GO:0030832,regulation of actin filament length;GO:0008360,regulation of cell shape;GO:0035023,regulation of Rho protein signal transduction;GO:0007266,Rho protein signal transduction;GO:0031532,actin cytoskeleton reorganization;GO:0008344,adult locomotory behavior;GO:0048149,behavioral response to ethanol;GO:1990830,cellular response to leukemia inhibitory factor;GO:0099072,regulation of postsynaptic membrane neurotransmitter receptor levels	
PTGR1_HUMAN	Q14914	PTGR1	Prostaglandin reductase 1	0.887143595	0.994759457	1.397400461	0.944075815	0.940951526	1.170738138	0.940951526	1.170738138	0.803725013697299	0.488200	0	1.24420664152257	0.488304	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome	GO:0036185,13-lipoxin reductase activity;GO:0036132,13-prostaglandin reductase activity;GO:0047522,15-oxoprostaglandin 13-oxidase activity;GO:0035798,2-alkenal reductase (NADP+) activity;GO:0097257,leukotriene B4 12-hydroxy dehydrogenase activity;GO:0032440,2-alkenal reductase [NAD(P)+] activity	GO:0036102,leukotriene B4 metabolic process;GO:0006691,leukotriene metabolic process;GO:2001302,lipoxin A4 metabolic process;GO:0006693,prostaglandin metabolic process;GO:0097327,response to antineoplastic agent	
NDUA5_HUMAN	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.332826835	0.203222446	0.254885087	0.199934763	0.2680246405	0.227409925	0.2680246405	0.227409925	1.1785969345885	0.379668	0	0.848466486423662	0.379360	0	GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I	GO:0008137,NADH dehydrogenase (ubiquinone) activity	GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0022904,respiratory electron transport chain	hsa:4698,path:hsa00190,Oxidative phosphorylation;hsa:4698,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4698,path:hsa04714,Thermogenesis;hsa:4698,path:hsa05010,Alzheimer disease;hsa:4698,path:hsa05012,Parkinson disease;hsa:4698,path:hsa05016,Huntington disease;hsa:4698,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
NU214_HUMAN	P35658	NUP214	Nuclear pore complex protein Nup214	0.662136587	0.426919	0.409900052	0.681243376	0.5445277935	0.545571714	0.5445277935	0.545571714	0.998086556774826	0.433986	0	1.0019171115092	0.433791	0	GO:1990876,cytoplasmic side of nuclear pore;GO:0005829,cytosol;GO:0043657,host cell;GO:0005643,nuclear pore;GO:0005654,nucleoplasm	GO:0005049,nuclear export signal receptor activity;GO:0008139,nuclear localization sequence binding;GO:0017056,structural constituent of nuclear pore	GO:0075733,intracellular transport of virus;GO:0000278,mitotic cell cycle;GO:0006406,mRNA export from nucleus;GO:0006611,protein export from nucleus;GO:0006606,protein import into nucleus;GO:0016925,protein sumoylation;GO:0051726,regulation of cell cycle;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0043488,regulation of mRNA stability;GO:0046822,regulation of nucleocytoplasmic transport;GO:0006405,RNA export from nucleus;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription	hsa:8021,path:hsa03013,RNA transport
PGH1_HUMAN	P23219	PTGS1	Prostaglandin G/H synthase 1	0.064073914	0.200082372	0.075475482	0.300818225	0.132078143	0.1881468535	0.132078143	0.1881468535	0.701994960548198	0.406562	0	1.42451165065214	0.406756	0	GO:0005737,cytoplasm;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0001750,photoreceptor outer segment	GO:0051213,dioxygenase activity;GO:0020037,heme binding;GO:0046872,metal ion binding;GO:0004601,peroxidase activity;GO:0004666,prostaglandin-endoperoxide synthase activity	GO:0019371,cyclooxygenase pathway;GO:0006954,inflammatory response;GO:0001516,prostaglandin biosynthetic process;GO:0006692,prostanoid metabolic process;GO:0008217,regulation of blood pressure;GO:0042127,regulation of cell population proliferation;GO:0006979,response to oxidative stress	hsa:5742,path:hsa00590,Arachidonic acid metabolism;hsa:5742,path:hsa04611,Platelet activation;hsa:5742,path:hsa04923,Regulation of lipolysis in adipocytes;hsa:5742,path:hsa04726,Serotonergic synapse
ITIH2_HUMAN	P19823	ITIH2	Inter-alpha-trypsin inhibitor heavy chain H2	3.902295878	2.724921637	5.337949686	22.81918273	3.3136087575	14.078566208	3.3136087575	14.078566208	0.23536549876912	0.028298	-1	4.24871106950531	0.028456	1	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region	GO:0004866,endopeptidase inhibitor activity;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0044267,cellular protein metabolic process;GO:0030212,hyaluronan metabolic process;GO:0043687,post-translational protein modification	
NGAL_HUMAN	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	1.834811936	6.786484131	0.940953997	0.027019231	4.3106480335	0.483986614	4.3106480335	0.483986614	8.90654391838201	0.022162	1	0.11227699646056	0.021920	-1	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0035580,specific granule lumen;GO:0005829,cytosol	GO:1903981,enterobactin binding;GO:0042802,identical protein binding;GO:0005506,iron ion binding;GO:0036094,small molecule binding;GO:0002020,protease binding	GO:0019730,antimicrobial humoral response;GO:0006915,apoptotic process;GO:0006879,cellular iron ion homeostasis;GO:0019221,cytokine-mediated signaling pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0043312,neutrophil degranulation;GO:0120162,positive regulation of cold-induced thermogenesis;GO:0097577,sequestering of iron ion;GO:0015891,siderophore transport;GO:0070301,cellular response to hydrogen peroxide;GO:0071347,cellular response to interleukin-1;GO:0071222,cellular response to lipopolysaccharide;GO:0031669,cellular response to nutrient levels;GO:0071356,cellular response to tumor necrosis factor;GO:0031346,positive regulation of cell projection organization;GO:0010628,positive regulation of gene expression;GO:0042493,response to drug;GO:0009635,response to herbicide;GO:0010046,response to mycotoxin	hsa:3934,path:hsa04657,IL-17 signaling pathway
RCC1_HUMAN	P18754	RCC1	Regulator of chromosome condensation	0.763674061	0.430900846	0.73607187	0.274259975	0.5972874535	0.5051659225	0.5972874535	0.5051659225	1.18235895751658	0.378646	0	0.845766840638986	0.378336	0	GO:0000785,chromatin;GO:0005694,chromosome;GO:0000794,condensed nuclear chromosome;GO:0005737,cytoplasm;GO:0031965,nuclear membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0003682,chromatin binding;GO:0005085,guanyl-nucleotide exchange factor activity;GO:0042393,histone binding;GO:0031492,nucleosomal DNA binding;GO:0031491,nucleosome binding;GO:0046982,protein heterodimerization activity;GO:0031267,small GTPase binding;GO:0043199,sulfate binding	GO:0051301,cell division;GO:0007059,chromosome segregation;GO:0000082,G1/S transition of mitotic cell cycle;GO:0007084,mitotic nuclear envelope reassembly;GO:0007052,mitotic spindle organization;GO:0031291,Ran protein signal transduction;GO:0007088,regulation of mitotic nuclear division;GO:1901673,regulation of mitotic spindle assembly;GO:0051225,spindle assembly;GO:0016032,viral process	
PTN11_HUMAN	Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	3.030810246	2.140311571	1.647416667	4.082531802	2.5855609085	2.8649742345	2.5855609085	2.8649742345	0.902472656600081	0.467579	0	1.10806681253628	0.467457	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0044853,plasma membrane raft;GO:0032991,protein-containing complex	GO:0045296,cadherin binding;GO:0050839,cell adhesion molecule binding;GO:0031748,D1 dopamine receptor binding;GO:0005158,insulin receptor binding;GO:0043560,insulin receptor substrate binding;GO:0004726,non-membrane spanning protein tyrosine phosphatase activity;GO:0051428,peptide hormone receptor binding;GO:0043274,phospholipase binding;GO:0004721,phosphoprotein phosphatase activity;GO:0001784,phosphotyrosine residue binding;GO:0019904,protein domain specific binding;GO:0019901,protein kinase binding;GO:1990782,protein tyrosine kinase binding;GO:0004725,protein tyrosine phosphatase activity;GO:0030971,receptor tyrosine kinase binding;GO:0030159,signaling receptor complex adaptor activity	GO:0033277,abortive mitotic cell cycle;GO:0000187,activation of MAPK activity;GO:0036302,atrioventricular canal development;GO:0007411,axon guidance;GO:0060020,Bergmann glial cell differentiation;GO:0007420,brain development;GO:1904385,cellular response to angiotensin;GO:0071345,cellular response to cytokine stimulus;GO:0071364,cellular response to epidermal growth factor stimulus;GO:0070301,cellular response to hydrogen peroxide;GO:1990314,cellular response to insulin-like growth factor stimulus;GO:0071260,cellular response to mechanical stimulus;GO:0021697,cerebellar cortex formation;GO:0019221,cytokine-mediated signaling pathway;GO:0000077,DNA damage checkpoint;GO:0048013,ephrin receptor signaling pathway;GO:0007173,epidermal growth factor receptor signaling pathway;GO:0038127,ERBB signaling pathway;GO:0060325,face morphogenesis;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0048806,genitalia development;GO:0042593,glucose homeostasis;GO:0007507,heart development;GO:0048873,homeostasis of number of cells within a tissue;GO:0042445,hormone metabolic process;GO:0009755,hormone-mediated signaling pathway;GO:0048839,inner ear development;GO:0007229,integrin-mediated signaling pathway;GO:0070102,interleukin-6-mediated signaling pathway;GO:0061582,intestinal epithelial cell migration;GO:0050900,leukocyte migration;GO:0035855,megakaryocyte development;GO:0032528,microvillus organization;GO:0035264,multicellular organism growth;GO:0048609,multicellular organismal reproductive process;GO:0033629,negative regulation of cell adhesion mediated by integrin;GO:0032331,negative regulation of chondrocyte differentiation;GO:0051463,negative regulation of cortisol secretion;GO:0060125,negative regulation of growth hormone secretion;GO:0046676,negative regulation of insulin secretion;GO:0048011,neurotrophin TRK receptor signaling pathway;GO:0035265,organ growth;GO:0035335,peptidyl-tyrosine dephosphorylation;GO:0030168,platelet activation;GO:0030220,platelet formation;GO:0048008,platelet-derived growth factor receptor signaling pathway;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0051894,positive regulation of focal adhesion assembly;GO:0046326,positive regulation of glucose import;GO:0046887,positive regulation of hormone secretion;GO:0046628,positive regulation of insulin receptor signaling pathway;GO:0032728,positive regulation of interferon-beta production;GO:0032755,positive regulation of interleukin-6 production;GO:0045931,positive regulation of mitotic cell cycle;GO:0045778,positive regulation of ossification;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0051897,positive regulation of protein kinase B signaling;GO:0032760,positive regulation of tumor necrosis factor production;GO:0033628,regulation of cell adhesion mediated by integrin;GO:0046825,regulation of protein export from nucleus;GO:0043254,regulation of protein-containing complex assembly;GO:0060338,regulation of type I interferon-mediated signaling pathway;GO:0048659,smooth muscle cell proliferation;GO:0031295,T cell costimulation;GO:0006641,triglyceride metabolic process	hsa:5781,path:hsa04014,Ras signaling pathway;hsa:5781,path:hsa04630,Jak-STAT signaling pathway;hsa:5781,path:hsa04072,Phospholipase D signaling pathway;hsa:5781,path:hsa04625,C-type lectin receptor signaling pathway;hsa:5781,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:5781,path:hsa04670,Leukocyte transendothelial migration;hsa:5781,path:hsa04920,Adipocytokine signaling pathway;hsa:5781,path:hsa04722,Neurotrophin signaling pathway;hsa:5781,path:hsa04360,Axon guidance;hsa:5781,path:hsa05205,Proteoglycans in cancer;hsa:5781,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:5781,path:hsa05220,Chronic myeloid leukemia;hsa:5781,path:hsa05211,Renal cell carcinoma;hsa:5781,path:hsa04931,Insulin resistance;hsa:5781,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:5781,path:hsa05130,Pathogenic Escherichia coli infection;hsa:5781,path:hsa05168,Herpes simplex virus 1 infection
INPP_HUMAN	P49441	INPP1	Inositol polyphosphate 1-phosphatase	0.05178031	0.042375631	0.126853182	2.55E-05	0.0470779705	0.063439341	0.0470779705	0.063439341	0.742094255045934	0.439789	0	1.34753771936707	0.439947	0	GO:0005829,cytosol	GO:0004441,inositol-1,4-bisphosphate 1-phosphatase activity;GO:0046872,metal ion binding	GO:0046855,inositol phosphate dephosphorylation;GO:0043647,inositol phosphate metabolic process;GO:0006796,phosphate-containing compound metabolic process;GO:0046854,phosphatidylinositol phosphorylation;GO:0007165,signal transduction	hsa:3628,path:hsa00562,Inositol phosphate metabolism;hsa:3628,path:hsa04070,Phosphatidylinositol signaling system
GPDM_HUMAN	P43304	GPD2	Glycerol-3-phosphate dehydrogenase, mitochondrial	16.92732303	6.217748396	18.31060056	3.998842329	11.572535713	11.1547214445	11.572535713	11.1547214445	1.03745627092338	0.421193	0	0.96389604846666	0.420970	0	GO:0009331,glycerol-3-phosphate dehydrogenase complex;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion	GO:0005509,calcium ion binding;GO:0004368,glycerol-3-phosphate dehydrogenase (quinone) activity;GO:0052591,sn-glycerol-3-phosphate	GO:0019563,glycerol catabolic process;GO:0006072,glycerol-3-phosphate metabolic process;GO:0006127,glycerophosphate shuttle	hsa:2820,path:hsa00564,Glycerophospholipid metabolism
TSN_HUMAN	Q15631	TSN	Translin	1.254142421	1.886608024	1.865754422	1.419233722	1.5703752225	1.642494072	1.5703752225	1.642494072	0.956091866187265	0.448282	0	1.0459245971706	0.448117	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0004521,endoribonuclease activity;GO:0042802,identical protein binding;GO:0044877,protein-containing complex binding;GO:0003723,RNA binding;GO:0043565,sequence-specific DNA binding;GO:0003697,single-stranded DNA binding	GO:0006310,DNA recombination;GO:0030422,production of siRNA involved in RNA interference;GO:0016070,RNA metabolic process	
PGRP2_HUMAN	Q96PD5	PGLYRP2	N-acetylmuramoyl-L-alanine amidase	0.223311184	0.17280649	0.341449395	1.121928115	0.198058837	0.731688755	0.198058837	0.731688755	0.270687277406634	0.045254	-1	3.69429996703454	0.045461	1	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0016020,membrane	GO:0008745,N-acetylmuramoyl-L-alanine amidase activity;GO:0042834,peptidoglycan binding;GO:0016019,peptidoglycan immune receptor activity;GO:0008270,zinc ion binding	GO:0019730,antimicrobial humoral response;GO:0051701,biological process involved in interaction with host;GO:0050830,defense response to Gram-positive bacterium;GO:0016045,detection of bacterium;GO:0045087,innate immune response;GO:0032689,negative regulation of interferon-gamma production;GO:0032827,negative regulation of natural killer cell differentiation involved in immune response;GO:0001519,peptide amidation;GO:0009253,peptidoglycan catabolic process;GO:0050727,regulation of inflammatory response	
SP100_HUMAN	P23497	SP100	Nuclear autoantigen Sp-100	0.05483998	0.026962338	0.079645963	0.036522061	0.040901159	0.058084012	0.040901159	0.058084012	0.704172414949573	0.408400	0	1.4201067505202	0.408591	0	GO:0000781,chromosome, telomeric region;GO:0005737,cytoplasm;GO:0016604,nuclear body;GO:0034399,nuclear periphery;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016605,PML body	GO:0070087,chromo shadow domain binding;GO:0003677,DNA binding;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0042802,identical protein binding;GO:0019900,kinase binding;GO:0046983,protein dimerization activity;GO:0019904,protein domain specific binding;GO:0042803,protein homodimerization activity;GO:0008134,transcription factor binding;GO:0046872,metal ion binding	GO:0006978,DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0045185,maintenance of protein location;GO:0051271,negative regulation of cellular component movement;GO:0043392,negative regulation of DNA binding;GO:0043433,negative regulation of DNA-binding transcription factor activity;GO:0010596,negative regulation of endothelial cell migration;GO:0046826,negative regulation of protein export from nucleus;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0032897,negative regulation of viral transcription;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0045893,positive regulation of transcription, DNA-templated;GO:0045765,regulation of angiogenesis;GO:1902041,regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902044,regulation of Fas signaling pathway;GO:0006357,regulation of transcription by RNA polymerase II;GO:0034097,response to cytokine;GO:0034341,response to interferon-gamma;GO:0032526,response to retinoic acid;GO:0034340,response to type I interferon;GO:0048384,retinoic acid receptor signaling pathway;GO:0000723,telomere maintenance;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process	hsa:6672,path:hsa05203,Viral carcinogenesis;hsa:6672,path:hsa05168,Herpes simplex virus 1 infection
MANBA_HUMAN	O00462	MANBA	Beta-mannosidase	0.475296458	0.305798258	0.410737773	0.562853269	0.390547358	0.486795521	0.390547358	0.486795521	0.802282151646995	0.487105	0	1.24644428141286	0.487211	0	GO:0035577,azurophil granule membrane;GO:0043202,lysosomal lumen;GO:0005764,lysosome;GO:0005886,plasma membrane	GO:0004567,beta-mannosidase activity;GO:0004553,hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0016798,hydrolase activity, acting on glycosyl bonds;GO:0005537,mannose binding	GO:0006464,cellular protein modification process;GO:0006516,glycoprotein catabolic process;GO:0043312,neutrophil degranulation;GO:0009313,oligosaccharide catabolic process;GO:0005975,carbohydrate metabolic process;GO:0008152,metabolic process	hsa:4126,path:hsa00511,Other glycan degradation;hsa:4126,path:hsa04142,Lysosome
NU160_HUMAN	Q12769	NUP160	Nuclear pore complex protein Nup160	0.175410734	0.05578812	0.433004753	0.155582497	0.115599427	0.294293625	0.115599427	0.294293625	0.392803027928315	0.130569	0	2.54580522271966	0.130891	0	GO:0005829,cytosol;GO:0043657,host cell;GO:0005635,nuclear envelope;GO:0005643,nuclear pore;GO:0031080,nuclear pore outer ring;GO:0005634,nucleus	GO:0017056,structural constituent of nuclear pore	GO:0075733,intracellular transport of virus;GO:0007084,mitotic nuclear envelope reassembly;GO:0007052,mitotic spindle organization;GO:0006406,mRNA export from nucleus;GO:0072006,nephron development;GO:0016925,protein sumoylation;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription	hsa:23279,path:hsa03013,RNA transport
APEX1_HUMAN	P27695	APEX1	DNA-(apurinic or apyrimidinic site) endonuclease	1.569010792	1.558669098	3.111599126	1.895999134	1.563839945	2.50379913	1.563839945	2.50379913	0.62458682338467	0.339090	0	1.60105843184611	0.339348	0	GO:0005813,centrosome;GO:0000781,chromosome, telomeric region;GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005739,mitochondrion;GO:0016607,nuclear speck;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005840,ribosome;GO:0005667,transcription regulator complex	GO:0008408,3'-5' exonuclease activity;GO:0031490,chromatin DNA binding;GO:0003684,damaged DNA binding;GO:0003677,DNA binding;GO:0003906,DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0008311,double-stranded DNA 3'-5' exodeoxyribonuclease activity;GO:0008309,double-stranded DNA exodeoxyribonuclease activity;GO:0003691,double-stranded telomeric DNA binding;GO:0004520,endodeoxyribonuclease activity;GO:0004519,endonuclease activity;GO:0046872,metal ion binding;GO:0051059,NF-kappaB binding;GO:0016491,oxidoreductase activity;GO:0004528,phosphodiesterase I activity;GO:0008081,phosphoric diester hydrolase activity;GO:0044877,protein-containing complex binding;GO:0003723,RNA binding;GO:0004523,RNA-DNA hybrid ribonuclease activity;GO:0016890,site-specific endodeoxyribonuclease activity, specific for altered base;GO:0003713,transcription coactivator activity;GO:0003714,transcription corepressor activity;GO:0004844,uracil DNA N-glycosylase activity	GO:0007568,aging;GO:0006284,base-excision repair;GO:0006286,base-excision repair, base-free sugar-phosphate removal;GO:0006287,base-excision repair, gap-filling;GO:0045454,cell redox homeostasis;GO:0071320,cellular response to cAMP;GO:0070301,cellular response to hydrogen peroxide;GO:0071375,cellular response to peptide hormone stimulus;GO:0080111,DNA demethylation;GO:0006310,DNA recombination;GO:0006281,DNA repair;GO:0014912,negative regulation of smooth muscle cell migration;GO:1900087,positive regulation of G1/S transition of mitotic cell cycle;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0042981,regulation of apoptotic process;GO:0043488,regulation of mRNA stability;GO:0042493,response to drug;GO:0000723,telomere maintenance;GO:0097698,telomere maintenance via base-excision repair	hsa:328,path:hsa03410,Base excision repair
PAAF1_HUMAN	Q9BRP4	PAAF1	Proteasomal ATPase-associated factor 1	0.11157348	0.089206625	0.157452623	0.075540147	0.1003900525	0.116496385	0.1003900525	0.116496385	0.861743928792297	0.483077	0	1.16043753438619	0.482989	0	GO:0000502,proteasome complex;GO:0016021,integral component of membrane		GO:0016032,viral process	
POSTN_HUMAN	Q15063	POSTN	Periostin	42.03332177	41.43981377	29.45111212	53.55660731	41.73656777	41.503859715	41.73656777	41.503859715	1.00560690154116	0.431498	0	0.994424360520434	0.431297	0	GO:0062023,collagen-containing extracellular matrix;GO:0031012,extracellular matrix;GO:0005615,extracellular space;GO:0031594,neuromuscular junction;GO:0005802,trans-Golgi network	GO:0050839,cell adhesion molecule binding;GO:0008201,heparin binding;GO:0046872,metal ion binding	GO:1990523,bone regeneration;GO:0007155,cell adhesion;GO:0044344,cellular response to fibroblast growth factor stimulus;GO:0071560,cellular response to transforming growth factor beta stimulus;GO:0071356,cellular response to tumor necrosis factor;GO:0071307,cellular response to vitamin K;GO:0030198,extracellular matrix organization;GO:0001953,negative regulation of cell-matrix adhesion;GO:1900025,negative regulation of substrate adhesion-dependent cell spreading;GO:1990138,neuron projection extension;GO:2000343,positive regulation of chemokine (C-X-C motif) ligand 2 production;GO:0014911,positive regulation of smooth muscle cell migration;GO:0008593,regulation of Notch signaling pathway;GO:0003073,regulation of systemic arterial blood pressure;GO:0032355,response to estradiol;GO:0001666,response to hypoxia;GO:0009612,response to mechanical stimulus;GO:0014850,response to muscle activity;GO:0009888,tissue development;GO:0042060,wound healing	
ATAD1_HUMAN	Q8NBU5	ATAD1	Outer mitochondrial transmembrane helix translocase	0.172443331	0.199839425	0.218131658	2.55E-05	0.186141378	0.109078579	0.186141378	0.109078579	1.70648884232348	0.268187	0	0.585998557505038	0.267690	0	GO:0005829,cytosol;GO:0098978,glutamatergic synapse;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005778,peroxisomal membrane;GO:0045211,postsynaptic membrane	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0140567,transmembrane protein dislocase activity	GO:0140570,extraction of mislocalized protein from mitochondrial outer membrane;GO:0007612,learning;GO:0007613,memory;GO:0051967,negative regulation of synaptic transmission, glutamatergic;GO:0002092,positive regulation of receptor internalization;GO:0045046,protein import into peroxisome membrane;GO:0099149,regulation of postsynaptic neurotransmitter receptor internalization	
AT5F1_HUMAN	P24539	ATP5PB	ATP synthase F(0) complex subunit B1, mitochondrial	7.422146678	27.63627314	3.583099383	2.432473165	17.529209909	3.007786274	17.529209909	3.007786274	5.82794398010475	0.049111	1	0.171587098883203	0.048724	-1	GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0005753,mitochondrial proton-transporting ATP synthase complex;GO:0000276,mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016021,integral component of membrane	GO:0015078,proton transmembrane transporter activity	GO:0006754,ATP biosynthetic process;GO:0015986,ATP synthesis coupled proton transport;GO:0042407,cristae formation;GO:0042776,mitochondrial ATP synthesis coupled proton transport;GO:0021762,substantia nigra development	hsa:515,path:hsa00190,Oxidative phosphorylation;hsa:515,path:hsa04714,Thermogenesis;hsa:515,path:hsa05010,Alzheimer disease;hsa:515,path:hsa05012,Parkinson disease;hsa:515,path:hsa05016,Huntington disease
AMPL_HUMAN	P28838	LAP3	Cytosol aminopeptidase	21.72170395	17.20718665	32.6895775	21.59455837	19.4644453	27.142067935	19.4644453	27.142067935	0.717131994018053	0.419257	0	1.39444343348433	0.419437	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0030496,midbody;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005802,trans-Golgi network;GO:0005737,cytoplasm	GO:0004177,aminopeptidase activity;GO:0004180,carboxypeptidase activity;GO:0030145,manganese ion binding;GO:0070006,metalloaminopeptidase activity;GO:0008235,metalloexopeptidase activity	GO:0006508,proteolysis	hsa:51056,path:hsa00330,Arginine and proline metabolism;hsa:51056,path:hsa00480,Glutathione metabolism
NU205_HUMAN	Q92621	NUP205	Nuclear pore complex protein Nup205	0.89690359	0.666246096	1.128368191	0.765960949	0.781574843	0.94716457	0.781574843	0.94716457	0.825173225176698	0.497653	0	1.21186675656601	0.497598	0	GO:0005829,cytosol;GO:0043657,host cell;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0034399,nuclear periphery;GO:0005643,nuclear pore;GO:0044611,nuclear pore inner ring	GO:0017056,structural constituent of nuclear pore	GO:0075733,intracellular transport of virus;GO:0007084,mitotic nuclear envelope reassembly;GO:0006406,mRNA export from nucleus;GO:0051292,nuclear pore complex assembly;GO:0006999,nuclear pore organization;GO:0006913,nucleocytoplasmic transport;GO:0016925,protein sumoylation;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription	hsa:23165,path:hsa03013,RNA transport
CLCC1_HUMAN	Q96S66	CLCC1	Chloride channel CLIC-like protein 1	0.107807107	0.144881879	0.240571744	0.164804788	0.126344493	0.202688266	0.126344493	0.202688266	0.623343894017032	0.337977	0	1.60425089520918	0.338235	0	GO:0034707,chloride channel complex;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0000139,Golgi membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0044233,mitochondria-associated endoplasmic reticulum membrane;GO:0031965,nuclear membrane;GO:0016021,integral component of membrane	GO:0005254,chloride channel activity	GO:0006821,chloride transport	
RAB10_HUMAN	P61026	RAB10	Ras-related protein Rab-10	4.696085451	18.38073312	0.770999099	1.046728499	11.5384092855	0.908863799	11.5384092855	0.908863799	12.6954217982886	0.010451	1	0.0787685526238131	0.010305	-1	GO:0005912,adherens junction;GO:0005929,cilium;GO:0030659,cytoplasmic vesicle membrane;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0071782,endoplasmic reticulum tubular network;GO:0005768,endosome;GO:0070382,exocytic vesicle;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0032593,insulin-responsive compartment;GO:0048471,perinuclear region of cytoplasm;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055037,recycling endosome;GO:0055038,recycling endosome membrane;GO:0030667,secretory granule membrane;GO:0008021,synaptic vesicle;GO:0005802,trans-Golgi network	GO:0098641,cadherin binding involved in cell-cell adhesion;GO:0003925,G protein activity;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0031489,myosin V binding	GO:0019882,antigen processing and presentation;GO:0007409,axonogenesis;GO:0032869,cellular response to insulin stimulus;GO:0071786,endoplasmic reticulum tubular network organization;GO:0016197,endosomal transport;GO:0045200,establishment of neuroblast polarity;GO:0097051,establishment of protein localization to endoplasmic reticulum membrane;GO:0090150,establishment of protein localization to membrane;GO:0043001,Golgi to plasma membrane protein transport;GO:0006893,Golgi to plasma membrane transport;GO:0043312,neutrophil degranulation;GO:0030859,polarized epithelial cell differentiation;GO:1903361,protein localization to basolateral plasma membrane;GO:0072659,protein localization to plasma membrane;GO:0009306,protein secretion;GO:0045055,regulated exocytosis;GO:0017157,regulation of exocytosis;GO:0006904,vesicle docking involved in exocytosis;GO:0016192,vesicle-mediated transport	hsa:10890,path:hsa04152,AMPK signaling pathway;hsa:10890,path:hsa04144,Endocytosis
PFD3_HUMAN	P61758	VBP1	Prefoldin subunit 3	1.014116741	1.03898605	0.093204675	2.55E-05	1.0265513955	0.0466150875	1.0265513955	0.0466150875	22.0218699686019	0.002768	1	0.0454094044432089	0.002715	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0005634,nucleus;GO:0005844,polysome;GO:0016272,prefoldin complex	GO:0001540,amyloid-beta binding;GO:0015631,tubulin binding;GO:0051082,unfolded protein binding	GO:0007017,microtubule-based process;GO:1905907,negative regulation of amyloid fibril formation;GO:0006457,protein folding;GO:0007021,tubulin complex assembly	
CNBP_HUMAN	P62633	CNBP	Cellular nucleic acid-binding protein	1.419399076	0.71640049	0.199299229	2.55E-05	1.067899783	0.0996623645	1.067899783	0.0996623645	10.7151760682941	0.015124	1	0.0933255780051039	0.014935	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005634,nucleus	GO:0051880,G-quadruplex DNA binding;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0003697,single-stranded DNA binding;GO:0003727,single-stranded RNA binding;GO:0045182,translation regulator activity;GO:0008270,zinc ion binding;GO:0003676,nucleic acid binding	GO:0042632,cholesterol homeostasis;GO:0071919,G-quadruplex DNA formation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0008284,positive regulation of cell population proliferation;GO:2000767,positive regulation of cytoplasmic translation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0006355,regulation of transcription, DNA-templated	
STRN_HUMAN	O43815	STRN	Striatin	0.096259671	0.026265281	0.13450322	0.117414165	0.061262476	0.1259586925	0.061262476	0.1259586925	0.486369577073849	0.212671	0	2.05604965264545	0.213003	0	GO:0005923,bicellular tight junction;GO:0005829,cytosol;GO:0030425,dendrite;GO:0043197,dendritic spine;GO:0090443,FAR/SIN/STRIPAK complex;GO:0016020,membrane;GO:0043025,neuronal cell body;GO:0014069,postsynaptic density;GO:0045211,postsynaptic membrane	GO:0070016,armadillo repeat domain binding;GO:0005516,calmodulin binding;GO:0030331,estrogen receptor binding;GO:0051721,protein phosphatase 2A binding;GO:0044877,protein-containing complex binding	GO:0070830,bicellular tight junction assembly;GO:0016358,dendrite development;GO:0007626,locomotory behavior;GO:0008285,negative regulation of cell population proliferation;GO:0051897,positive regulation of protein kinase B signaling;GO:0016055,Wnt signaling pathway	
DPP2_HUMAN	Q9UHL4	DPP7	Dipeptidyl peptidase 2	0.697910648	0.299280716	1.656824137	0.57725438	0.498595682	1.1170392585	0.498595682	1.1170392585	0.446354663191992	0.176602	0	2.24037090337256	0.176938	0	GO:0035578,azurophil granule lumen;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0031982,vesicle	GO:0004177,aminopeptidase activity;GO:0008239,dipeptidyl-peptidase activity;GO:0008236,serine-type peptidase activity	GO:0043312,neutrophil degranulation;GO:0006508,proteolysis	
EXOC3_HUMAN	O60645	EXOC3	Exocyst complex component 3	0.156189845	0.063021264	0.233907777	0.533864337	0.1096055545	0.383886057	0.1096055545	0.383886057	0.285515851647615	0.053565	0	3.50243250673943	0.053792	0	GO:0005576,extracellular region;GO:0005829,cytosol;GO:0000145,exocyst;GO:0005794,Golgi apparatus;GO:0030426,growth cone;GO:0030496,midbody;GO:0048471,perinuclear region of cytoplasm;GO:0042734,presynaptic membrane;GO:0030667,secretory granule membrane	GO:0045296,cadherin binding;GO:0000149,SNARE binding	GO:0060271,cilium assembly;GO:0051601,exocyst localization;GO:0006887,exocytosis;GO:0015031,protein transport	
ABRAL_HUMAN	Q9P1F3	ABRACL	Costars family protein ABRACL	0.160930215	0.344805165	0.215439026	0.102259862	0.25286769	0.158849444	0.25286769	0.158849444	1.59187016103122	0.287841	0	0.628191937056095	0.287372	0			GO:0032970,regulation of actin filament-based process	
DBLOH_HUMAN	Q9NR28	DIABLO	Diablo homolog, mitochondrial	1.488535945	3.334083515	0.109368431	0.065775863	2.41130973	0.087572147	2.41130973	0.087572147	27.5351217550941	0.001527	1	0.0363172536113807	0.001494	-1	GO:0035631,CD40 receptor complex;GO:0009898,cytoplasmic side of plasma membrane;GO:0005829,cytosol;GO:0005758,mitochondrial intermembrane space;GO:0005739,mitochondrion		GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0008635,activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;GO:0006915,apoptotic process;GO:0008625,extrinsic apoptotic signaling pathway via death domain receptors;GO:0097193,intrinsic apoptotic signaling pathway;GO:0008631,intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0051402,neuron apoptotic process;GO:0043065,positive regulation of apoptotic process	hsa:56616,path:hsa04210,Apoptosis;hsa:56616,path:hsa04215,Apoptosis - multiple species
CSTF3_HUMAN	Q12996	CSTF3	Cleavage stimulation factor subunit 3	0.384440186	0.304512139	0.444372306	0.041761748	0.3444761625	0.243067027	0.3444761625	0.243067027	1.41720646667555	0.322132	0	0.705613489293327	0.321718	0	GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0031124,mRNA 3'-end processing;GO:0006379,mRNA cleavage;GO:0006378,mRNA polyadenylation;GO:0000398,mRNA splicing, via spliceosome;GO:0031123,RNA 3'-end processing;GO:0006369,termination of RNA polymerase II transcription;GO:0006397,mRNA processing	hsa:1479,path:hsa03015,mRNA surveillance pathway
NAPSA_HUMAN	O96009	NAPSA	Napsin-A	2.254611471	6.184964845	13.26289596	12.07330031	4.219788158	12.668098135	4.219788158	12.668098135	0.333103526119787	0.084467	0	3.00206969181224	0.084747	0	GO:0097208,alveolar lamellar body;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005764,lysosome;GO:0097486,multivesicular body lumen	GO:0004190,aspartic-type endopeptidase activity;GO:0004175,endopeptidase activity;GO:0008233,peptidase activity	GO:0044267,cellular protein metabolic process;GO:0033619,membrane protein proteolysis;GO:0006508,proteolysis;GO:0043129,surfactant homeostasis	hsa:9476,path:hsa04142,Lysosome
CD68_HUMAN	P34810	CD68	Macrosialin	0.308253749	0.63157543	0.999166415	0.977382419	0.4699145895	0.988274417	0.4699145895	0.988274417	0.475489986805962	0.202772	0	2.10309370911754	0.203106	0	GO:0035577,azurophil granule membrane;GO:0016021,integral component of membrane;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0016020,membrane;GO:0005886,plasma membrane		GO:0007568,aging;GO:0035425,autocrine signaling;GO:0071222,cellular response to lipopolysaccharide;GO:0031669,cellular response to nutrient levels;GO:0140052,cellular response to oxidised low-density lipoprotein particle stimulus;GO:0072594,establishment of protein localization to organelle;GO:0002437,inflammatory response to antigenic stimulus;GO:0002605,negative regulation of dendritic cell antigen processing and presentation;GO:0043312,neutrophil degranulation	hsa:968,path:hsa04142,Lysosome
PAXX_HUMAN	Q9BUH6	PAXX	Protein PAXX	0.523395835	1.044264238	0.152770443	0.021496268	0.7838300365	0.0871333555	0.7838300365	0.0871333555	8.99575176466147	0.021722	1	0.111163583229181	0.021483	-1	GO:0070419,nonhomologous end joining complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0035861,site of double-strand break	GO:0042802,identical protein binding;GO:0060090,molecular adaptor activity;GO:0042803,protein homodimerization activity	GO:0006974,cellular response to DNA damage stimulus;GO:0006303,double-strand break repair via nonhomologous end joining	
PIPNB_HUMAN	P48739	PITPNB	Phosphatidylinositol transfer protein beta isoform	0.643321431	0.493896471	0.932665604	0.554171503	0.568608951	0.7434185535	0.568608951	0.7434185535	0.764857089351618	0.458056	0	1.3074337858955	0.458194	0	GO:0005737,cytoplasm;GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane	GO:0031210,phosphatidylcholine binding;GO:0120019,phosphatidylcholine transfer activity;GO:0008525,phosphatidylcholine transporter activity;GO:0035091,phosphatidylinositol binding;GO:0008526,phosphatidylinositol transfer activity;GO:0140338,sphingomyelin transfer activity;GO:0005548,phospholipid transporter activity	GO:0006629,lipid metabolic process;GO:0006997,nucleus organization;GO:0015914,phospholipid transport;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	
VIGLN_HUMAN	Q00341	HDLBP	Vigilin	10.53584051	5.405811993	11.1276531	9.705119546	7.9708262515	10.416386323	7.9708262515	10.416386323	0.765219914501437	0.458343	0	1.30681387278261	0.458481	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0034364,high-density lipoprotein particle;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0005844,polysome	GO:0045296,cadherin binding;GO:0008289,lipid binding;GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0008203,cholesterol metabolic process;GO:0034384,high-density lipoprotein particle clearance;GO:0006869,lipid transport	
PSB10_HUMAN	P40306	PSMB10	Proteasome subunit beta type-10	1.526619691	0.895284932	1.738117115	0.306424641	1.2109523115	1.022270878	1.2109523115	1.022270878	1.18457087799385	0.378047	0	0.844187560725425	0.377736	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000502,proteasome complex;GO:0005839,proteasome core complex;GO:0019774,proteasome core complex, beta-subunit complex;GO:1990111,spermatoproteasome complex	GO:0004175,endopeptidase activity;GO:0004298,threonine-type endopeptidase activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0000902,cell morphogenesis;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0006959,humoral immune response;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0042098,T cell proliferation;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0002376,immune system process;GO:0051603,proteolysis involved in cellular protein catabolic process	hsa:5699,path:hsa03050,Proteasome
UN93B_HUMAN	Q9H1C4	UNC93B1	Protein unc-93 homolog B1	0.184872493	0.519836169	0.555526208	2.025533749	0.352354331	1.2905299785	0.352354331	1.2905299785	0.273030721385912	0.046522	-1	3.66259150224551	0.046732	1	GO:0032009,early phagosome;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005768,endosome;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0005764,lysosome	GO:0035325,Toll-like receptor binding	GO:0002250,adaptive immune response;GO:0051607,defense response to virus;GO:0045087,innate immune response;GO:0006886,intracellular protein transport;GO:0034138,toll-like receptor 3 signaling pathway;GO:0034154,toll-like receptor 7 signaling pathway;GO:0034162,toll-like receptor 9 signaling pathway;GO:0002224,toll-like receptor signaling pathway	
WDR47_HUMAN	O94967	WDR47	WD repeat-containing protein 47	0.117757013	0.138245699	0.324792399	0.115726582	0.128001356	0.2202594905	0.128001356	0.2202594905	0.581138890812062	0.299746	0	1.72075904024017	0.300034	0	GO:0005737,cytoplasm;GO:0005874,microtubule		GO:0007275,multicellular organism development	
HCDH_HUMAN	Q16836	HADH	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	2.865530879	3.592024919	4.559942789	1.826364761	3.228777899	3.193153775	3.228777899	3.193153775	1.01115640727325	0.429676	0	0.988966684883766	0.429471	0	GO:0005737,cytoplasm;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0003857,3-hydroxyacyl-CoA dehydrogenase activity;GO:0042802,identical protein binding;GO:0070403,NAD+ binding;GO:0016740,transferase activity;GO:0016616,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO:0006635,fatty acid beta-oxidation;GO:0120162,positive regulation of cold-induced thermogenesis;GO:0050796,regulation of insulin secretion;GO:0006631,fatty acid metabolic process;GO:0046676,negative regulation of insulin secretion;GO:0014823,response to activity;GO:0042493,response to drug;GO:0032868,response to insulin	hsa:3033,path:hsa00650,Butanoate metabolism;hsa:3033,path:hsa00062,Fatty acid elongation;hsa:3033,path:hsa00071,Fatty acid degradation;hsa:3033,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:3033,path:hsa00310,Lysine degradation;hsa:3033,path:hsa00380,Tryptophan metabolism
HBA_HUMAN	P69905	HBA1	Hemoglobin subunit alpha	261.713907	2214.054304	508.5514295	4133.509881	1237.8841055	2321.03065525	1237.8841055	2321.03065525	0.533333802679425	0.255810	0	1.8749983499566	0.256125	0	GO:0072562,blood microparticle;GO:0005829,cytosol;GO:0022627,cytosolic small ribosomal subunit;GO:0071682,endocytic vesicle lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0031838,haptoglobin-hemoglobin complex;GO:0005833,hemoglobin complex;GO:0016020,membrane	GO:0020037,heme binding;GO:0005506,iron ion binding;GO:0043177,organic acid binding;GO:0019825,oxygen binding;GO:0005344,oxygen carrier activity;GO:0046872,metal ion binding	GO:0015701,bicarbonate transport;GO:0098869,cellular oxidant detoxification;GO:0042744,hydrogen peroxide catabolic process;GO:0015671,oxygen transport;GO:0010942,positive regulation of cell death;GO:0006898,receptor-mediated endocytosis;GO:0042542,response to hydrogen peroxide	hsa:3039,path:hsa05144,Malaria;hsa:3039,path:hsa05143,African trypanosomiasis;hsa:3040,path:hsa05144,Malaria;hsa:3040,path:hsa05143,African trypanosomiasis
LAMP2_HUMAN	P13473	LAMP2	Lysosome-associated membrane glycoprotein 2	1.178222749	1.683109374	2.084944627	1.843558852	1.4306660615	1.9642517395	1.4306660615	1.9642517395	0.728351683610664	0.428549	0	1.37296312001737	0.428719	0	GO:0044754,autolysosome;GO:0035577,azurophil granule membrane;GO:0061742,chaperone-mediated autophagy translocation complex;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0101003,ficolin-1-rich granule membrane;GO:0097637,integral component of autophagosome membrane;GO:0005770,late endosome;GO:0031902,late endosome membrane;GO:0043202,lysosomal lumen;GO:1990836,lysosomal matrix;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0016020,membrane;GO:0045121,membrane raft;GO:0048471,perinuclear region of cytoplasm;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0031088,platelet dense granule membrane;GO:0005802,trans-Golgi network;GO:0016021,integral component of membrane	GO:0019899,enzyme binding;GO:0019904,protein domain specific binding	GO:0097352,autophagosome maturation;GO:0009267,cellular response to starvation;GO:0061684,chaperone-mediated autophagy;GO:0072594,establishment of protein localization to organelle;GO:1905146,lysosomal protein catabolic process;GO:0046716,muscle cell cellular homeostasis;GO:0031333,negative regulation of protein-containing complex assembly;GO:0043312,neutrophil degranulation;GO:0002576,platelet degranulation;GO:0017038,protein import;GO:0050821,protein stabilization;GO:0006605,protein targeting;GO:0061740,protein targeting to lysosome involved in chaperone-mediated autophagy;GO:0031647,regulation of protein stability	hsa:3920,path:hsa04145,Phagosome;hsa:3920,path:hsa04142,Lysosome;hsa:3920,path:hsa04140,Autophagy - animal;hsa:3920,path:hsa05152,Tuberculosis
RL3_HUMAN	P39023	RPL3	60S ribosomal protein L3	5.775053938	7.416452095	1.051705269	0.265425312	6.5957530165	0.6585652905	6.5957530165	0.6585652905	10.0153365378432	0.017433	1	0.0998468694707832	0.017226	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005730,nucleolus;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0045202,synapse;GO:0005840,ribosome	GO:0008097,5S rRNA binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0071353,cellular response to interleukin-4;GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000027,ribosomal large subunit assembly;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6122,path:hsa03010,Ribosome
CRIP2_HUMAN	P52943	CRIP2	Cysteine-rich protein 2	0.654593522	2.47452508	0.181867082	0.248622348	1.564559301	0.215244715	1.564559301	0.215244715	7.26874664959834	0.032903	1	0.137575299870337	0.032594	-1	GO:0005938,cell cortex	GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0030097,hemopoiesis;GO:0008284,positive regulation of cell population proliferation	
EF1D_HUMAN	P29692	EEF1D	Elongation factor 1-delta	9.828093496	10.24169486	9.516894777	6.675271084	10.034894178	8.0960829305	10.034894178	8.0960829305	1.23947522081277	0.363619	0	0.806793055002956	0.363280	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005853,eukaryotic translation elongation factor 1 complex;GO:0001650,fibrillar center;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0033613,activating transcription factor binding;GO:0045296,cadherin binding;GO:0003677,DNA binding;GO:0005085,guanyl-nucleotide exchange factor activity;GO:0031072,heat shock protein binding;GO:0003746,translation elongation factor activity;GO:0008135,translation factor activity, RNA binding	GO:0071479,cellular response to ionizing radiation;GO:0009299,mRNA transcription;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0010941,regulation of cell death;GO:0006414,translational elongation	
RL13_HUMAN	P26373	RPL13	60S ribosomal protein L13	42.13531847	13.94640359	19.80609894	1.089086775	28.04086103	10.4475928575	28.04086103	10.4475928575	2.68395422873608	0.158655	0	0.372584595256275	0.158085	0	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0005783,endoplasmic reticulum;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005634,nucleus;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0001824,blastocyst development;GO:0060348,bone development;GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6137,path:hsa03010,Ribosome
ATP5L_HUMAN	O75964	ATP5MG	ATP synthase subunit g, mitochondrial	2.959600919	3.700771601	1.737543983	1.875987671	3.33018626	1.806765827	3.33018626	1.806765827	1.84317536353315	0.247224	0	0.542541973913495	0.246703	0	GO:0005743,mitochondrial inner membrane;GO:0005753,mitochondrial proton-transporting ATP synthase complex;GO:0000276,mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0005739,mitochondrion	GO:0015078,proton transmembrane transporter activity	GO:0006754,ATP biosynthetic process;GO:0015986,ATP synthesis coupled proton transport;GO:0042407,cristae formation;GO:0042776,mitochondrial ATP synthesis coupled proton transport	hsa:10632,path:hsa00190,Oxidative phosphorylation;hsa:10632,path:hsa04714,Thermogenesis
TIAR_HUMAN	Q01085	TIAL1	Nucleolysin TIAR	0.870382286	0.610834397	1.082314192	0.555908896	0.7406083415	0.819111544	0.7406083415	0.819111544	0.904160546783846	0.466953	0	1.10599826939702	0.466829	0	GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005764,lysosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex	GO:0003677,DNA binding;GO:0003723,RNA binding	GO:0006915,apoptotic process;GO:0006952,defense response;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0006357,regulation of transcription by RNA polymerase II	
ANKH1_HUMAN	Q8IWZ3	ANKHD1	Ankyrin repeat and KH domain-containing protein 1	0.315261527	0.088686854	0.302274025	0.203547664	0.2019741905	0.2529108445	0.2019741905	0.2529108445	0.798598379200778	0.484301	0	1.25219387622697	0.484410	0	GO:0005737,cytoplasm	GO:0003723,RNA binding	GO:0045087,innate immune response	
VAMP8_HUMAN	Q9BV40	VAMP8	Vesicle-associated membrane protein 8	3.244984276	1.000180294	0.496441134	0.235670141	2.122582285	0.3660556375	2.122582285	0.3660556375	5.79852368753643	0.049546	1	0.172457689902938	0.049158	-1	GO:0035577,azurophil granule membrane;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0098594,mucin granule;GO:0048471,perinuclear region of cytoplasm;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055037,recycling endosome;GO:0055038,recycling endosome membrane;GO:0030667,secretory granule membrane;GO:0031201,SNARE complex;GO:0035579,specific granule membrane;GO:0070821,tertiary granule membrane;GO:0031982,vesicle	GO:0019869,chloride channel inhibitor activity;GO:0005484,SNAP receptor activity;GO:0019905,syntaxin binding	GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0097352,autophagosome maturation;GO:0016240,autophagosome membrane docking;GO:0051607,defense response to virus;GO:0061024,membrane organization;GO:0070254,mucus secretion;GO:1903531,negative regulation of secretion by cell;GO:0043312,neutrophil degranulation;GO:1903595,positive regulation of histamine secretion by mast cell;GO:0006892,post-Golgi vesicle-mediated transport;GO:0015031,protein transport;GO:1903076,regulation of protein localization to plasma membrane;GO:0035493,SNARE complex assembly;GO:0006906,vesicle fusion;GO:0046718,viral entry into host cell;GO:0016192,vesicle-mediated transport	hsa:8673,path:hsa04130,SNARE interactions in vesicular transport;hsa:8673,path:hsa04140,Autophagy - animal;hsa:8673,path:hsa04611,Platelet activation
SPRC_HUMAN	P09486	SPARC	SPARC	0.026710301	0.066630659	0.270475279	0.272808761	0.04667048	0.27164202	0.04667048	0.27164202	0.171808765079865	0.008483	-1	5.82042481671498	0.008552	1	GO:0005604,basement membrane;GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0071682,endocytic vesicle lumen;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0098978,glutamatergic synapse;GO:0043231,intracellular membrane-bounded organelle;GO:0016363,nuclear matrix;GO:0005886,plasma membrane;GO:0031091,platelet alpha granule;GO:0031093,platelet alpha granule lumen;GO:0031092,platelet alpha granule membrane;GO:0016020,membrane	GO:0005509,calcium ion binding;GO:0005518,collagen binding;GO:0050840,extracellular matrix binding	GO:0048856,anatomical structure development;GO:0030198,extracellular matrix organization;GO:0007507,heart development;GO:0048839,inner ear development;GO:0030324,lung development;GO:0016525,negative regulation of angiogenesis;GO:0001937,negative regulation of endothelial cell proliferation;GO:0001503,ossification;GO:0002576,platelet degranulation;GO:0010595,positive regulation of endothelial cell migration;GO:0006898,receptor-mediated endocytosis;GO:0022604,regulation of cell morphogenesis;GO:0050807,regulation of synapse organization;GO:0046686,response to cadmium ion;GO:0051592,response to calcium ion;GO:0051591,response to cAMP;GO:0034097,response to cytokine;GO:0045471,response to ethanol;GO:0051384,response to glucocorticoid;GO:0009629,response to gravity;GO:0033591,response to L-ascorbic acid;GO:0010288,response to lead ion;GO:0032496,response to lipopolysaccharide;GO:0043434,response to peptide hormone;GO:0042060,wound healing	
CSN6_HUMAN	Q7L5N1	COPS6	COP9 signalosome complex subunit 6	0.90932563	0.954703908	1.245149351	1.669043883	0.932014769	1.457096617	0.932014769	1.457096617	0.639638276642845	0.352509	0	1.56338361307663	0.352754	0	GO:0008180,COP9 signalosome;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm;GO:0005737,cytoplasm	GO:0070122,isopeptidase activity;GO:0008237,metallopeptidase activity	GO:0000715,nucleotide-excision repair, DNA damage recognition;GO:0043687,post-translational protein modification;GO:0000338,protein deneddylation;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0016032,viral process	
TM205_HUMAN	Q6UW68	TMEM205	Transmembrane protein 205	1.920274364	8.131045286	0.467374311	0.112262064	5.025659825	0.2898181875	5.025659825	0.2898181875	17.3407330587215	0.005047	1	0.0576676889387355	0.004962	-1	GO:0016021,integral component of membrane			
NFIB_HUMAN	O00712	NFIB	Nuclear factor 1 B-type	2.55E-05	2.55E-05	2.55E-05	2.55E-05	2.55e-005	2.55e-005	2.55e-005	2.55e-005	1	0.433351	0	1	0.433154	0	GO:0044300,cerebellar mossy fiber;GO:0000785,chromatin;GO:0001650,fibrillar center;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0001228,DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:1990837,sequence-specific double-stranded DNA binding;GO:0140416,transcription regulator inhibitor activity;GO:0003700,DNA-binding transcription factor activity;GO:0003690,double-stranded DNA binding	GO:0021960,anterior commissure morphogenesis;GO:0007420,brain development;GO:0002062,chondrocyte differentiation;GO:0060486,club cell differentiation;GO:0071679,commissural neuron axon guidance;GO:0006260,DNA replication;GO:0010001,glial cell differentiation;GO:0061141,lung ciliated cell differentiation;GO:0043392,negative regulation of DNA binding;GO:2000795,negative regulation of epithelial cell proliferation involved in lung morphogenesis;GO:2000791,negative regulation of mesenchymal cell proliferation involved in lung development;GO:1902894,negative regulation of pri-miRNA transcription by RNA polymerase II;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0021740,principal sensory nucleus of trigeminal nerve development;GO:0006357,regulation of transcription by RNA polymerase II;GO:0060509,type I pneumocyte differentiation;GO:0060510,type II pneumocyte differentiation;GO:0060689,cell differentiation involved in salivary gland development;GO:0030902,hindbrain development;GO:0009617,response to bacterium;GO:0060662,salivary gland cavitation	
NPC1_HUMAN	O15118	NPC1	NPC intracellular cholesterol transporter 1	0.153760163	0.144027326	0.298346647	2.55E-05	0.1488937445	0.1491860735	0.1488937445	0.1491860735	0.998040507447232	0.434002	0	1.00196333970229	0.433806	0	GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005794,Golgi apparatus;GO:1905103,integral component of lysosomal membrane;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0016020,membrane;GO:0045121,membrane raft;GO:0005635,nuclear envelope;GO:0048471,perinuclear region of cytoplasm	GO:0015485,cholesterol binding;GO:0038023,signaling receptor activity;GO:0015248,sterol transporter activity;GO:0004888,transmembrane signaling receptor activity;GO:0001618,virus receptor activity;GO:0005319,lipid transporter activity	GO:0007628,adult walking behavior;GO:0006914,autophagy;GO:0008206,bile acid metabolic process;GO:0071404,cellular response to low-density lipoprotein particle stimulus;GO:0071383,cellular response to steroid hormone stimulus;GO:0033344,cholesterol efflux;GO:0042632,cholesterol homeostasis;GO:0008203,cholesterol metabolic process;GO:0030301,cholesterol transport;GO:0006897,endocytosis;GO:0090150,establishment of protein localization to membrane;GO:0010467,gene expression;GO:0032367,intracellular cholesterol transport;GO:0034383,low-density lipoprotein particle clearance;GO:0007041,lysosomal transport;GO:0031579,membrane raft organization;GO:0060548,negative regulation of cell death;GO:0016242,negative regulation of macroautophagy;GO:0006486,protein glycosylation;GO:0046686,response to cadmium ion;GO:0042493,response to drug;GO:0046718,viral entry into host cell	hsa:4864,path:hsa04142,Lysosome;hsa:4864,path:hsa04979,Cholesterol metabolism
GSHR_HUMAN	P00390	GSR	Glutathione reductase, mitochondrial	3.243227491	4.04125725	7.198046574	7.586372325	3.6422423705	7.3922094495	3.6422423705	7.3922094495	0.492713632558985	0.218467	0	2.02957647996534	0.218797	0	GO:0005829,cytosol;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0009055,electron transfer activity;GO:0050660,flavin adenine dinucleotide binding;GO:0004362,glutathione-disulfide reductase activity;GO:0050661,NADP binding	GO:0045454,cell redox homeostasis;GO:0034599,cellular response to oxidative stress;GO:0006749,glutathione metabolic process;GO:0015949,nucleobase-containing small molecule interconversion	hsa:2936,path:hsa00480,Glutathione metabolism;hsa:2936,path:hsa04918,Thyroid hormone synthesis
P4HA1_HUMAN	P13674	P4HA1	Prolyl 4-hydroxylase subunit alpha-1	1.911531206	0.398930228	1.393266381	1.347853081	1.155230717	1.370559731	1.155230717	1.370559731	0.842889726635344	0.490511	0	1.18639481346132	0.490440	0	GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005739,mitochondrion	GO:0042802,identical protein binding;GO:0005506,iron ion binding;GO:0031418,L-ascorbic acid binding;GO:0016702,oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0004656,procollagen-proline 4-dioxygenase activity	GO:0030199,collagen fibril organization;GO:0018401,peptidyl-proline hydroxylation to 4-hydroxy-L-proline	hsa:5033,path:hsa00330,Arginine and proline metabolism
ST1A4_HUMAN	P0DMN0	SULT1A4	Sulfotransferase 1A4	1.456178468	1.64218299	1.844429636	3.566413459	1.549180729	2.7054215475	1.549180729	2.7054215475	0.572620828880273	0.291950	0	1.74635631392495	0.292244	0	GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0004062,aryl sulfotransferase activity;GO:0008146,sulfotransferase activity	GO:0050427,3'-phosphoadenosine 5'-phosphosulfate metabolic process;GO:0006584,catecholamine metabolic process;GO:0008202,steroid metabolic process;GO:0051923,sulfation	hsa:445329,path:hsa05204,Chemical carcinogenesis;hsa:6818,path:hsa05204,Chemical carcinogenesis
SF3B3_HUMAN	Q15393	SF3B3	Splicing factor 3B subunit 3	7.086850938	3.118507763	8.451302377	7.297618347	5.1026793505	7.874460362	5.1026793505	7.874460362	0.648003687354138	0.359910	0	1.54320109517138	0.360149	0	GO:0071013,catalytic step 2 spliceosome;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005689,U12-type spliceosomal complex;GO:0005686,U2 snRNP;GO:0071005,U2-type precatalytic spliceosome	GO:0044877,protein-containing complex binding;GO:0030620,U2 snRNA binding	GO:0000398,mRNA splicing, via spliceosome;GO:0042177,negative regulation of protein catabolic process;GO:0008380,RNA splicing;GO:0000375,RNA splicing, via transesterification reactions	hsa:23450,path:hsa03040,Spliceosome
UBE3A_HUMAN	Q05086	UBE3A	Ubiquitin-protein ligase E3A	0.103077168	2.849605375	0.153139365	0.108430669	1.4763412715	0.130785017	1.4763412715	0.130785017	11.288305842404	0.013526	1	0.0885872525036973	0.013352	-1	GO:0005829,cytosol;GO:0005634,nucleus;GO:0000502,proteasome complex	GO:0046872,metal ion binding;GO:0003713,transcription coactivator activity;GO:0061630,ubiquitin protein ligase activity;GO:0004842,ubiquitin-protein transferase activity	GO:0030521,androgen receptor signaling pathway;GO:0007420,brain development;GO:1990416,cellular response to brain-derived neurotrophic factor stimulus;GO:0061002,negative regulation of dendritic spine morphogenesis;GO:0001541,ovarian follicle development;GO:1905528,positive regulation of Golgi lumen acidification;GO:0014068,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0031398,positive regulation of protein ubiquitination;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0050847,progesterone receptor signaling pathway;GO:0060736,prostate gland growth;GO:0051865,protein autoubiquitination;GO:0070936,protein K48-linked ubiquitination;GO:0006508,proteolysis;GO:0042752,regulation of circadian rhythm;GO:2000058,regulation of ubiquitin-dependent protein catabolic process;GO:0042220,response to cocaine;GO:0042542,response to hydrogen peroxide;GO:0032570,response to progesterone;GO:0048511,rhythmic process;GO:0035037,sperm entry;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0016032,viral process	hsa:7337,path:hsa04120,Ubiquitin mediated proteolysis;hsa:7337,path:hsa05203,Viral carcinogenesis;hsa:7337,path:hsa05165,Human papillomavirus infection
NAA10_HUMAN	P41227	NAA10	N-alpha-acetyltransferase 10	1.089341353	0.583267682	1.135440063	1.115869332	0.8363045175	1.1256546975	0.8363045175	1.1256546975	0.742949431435212	0.440483	0	1.34598662801077	0.440641	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0031415,NatA complex;GO:0005730,nucleolus;GO:0005634,nucleus	GO:0008080,N-acetyltransferase activity;GO:0004596,peptide alpha-N-acetyltransferase activity;GO:1990190,peptide-glutamate-N-acetyltransferase activity;GO:1990189,peptide-serine-N-acetyltransferase activity	GO:0006323,DNA packaging;GO:0006475,internal protein amino acid acetylation;GO:0018002,N-terminal peptidyl-glutamic acid acetylation;GO:0017198,N-terminal peptidyl-serine acetylation;GO:0006474,N-terminal protein amino acid acetylation;GO:2000719,negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric;GO:0006473,protein acetylation	
SKT_HUMAN	Q5T5P2	KIAA1217	Sickle tail protein homolog	0.450531878	0.55876212	0.231875863	0.581770251	0.504646999	0.406823057	0.504646999	0.406823057	1.24045820490455	0.363368	0	0.806153722911567	0.363028	0	GO:0005737,cytoplasm	GO:0030234,enzyme regulator activity	GO:0048706,embryonic skeletal system development	
RAB31_HUMAN	Q13636	RAB31	Ras-related protein Rab-31	0.755399344	2.848679512	0.096241985	0.333624125	1.802039428	0.214933055	1.802039428	0.214933055	8.38418933746603	0.024994	1	0.119272115615441	0.024732	-1	GO:0005829,cytosol;GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0036186,early phagosome membrane;GO:0012505,endomembrane system;GO:0001891,phagocytic cup;GO:0045335,phagocytic vesicle;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0032588,trans-Golgi network membrane	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0032869,cellular response to insulin stimulus;GO:0043001,Golgi to plasma membrane protein transport;GO:0006886,intracellular protein transport;GO:0043312,neutrophil degranulation;GO:0090382,phagosome maturation;GO:0060100,positive regulation of phagocytosis, engulfment;GO:0031623,receptor internalization;GO:0045055,regulated exocytosis	hsa:11031,path:hsa04144,Endocytosis
S35U4_HUMAN	L0R6Q1	SLC35A4	SLC35A4 upstream open reading frame protein	0.045911487	0.363958228	0.139805162	0.075919787	0.2049348575	0.1078624745	0.2049348575	0.1078624745	1.89996436156302	0.239216	0	0.526325661802068	0.238686	0	GO:0016021,integral component of membrane;GO:0005794,Golgi apparatus;GO:0030173,integral component of Golgi membrane	GO:0015165,pyrimidine nucleotide-sugar transmembrane transporter activity	GO:0032056,positive regulation of translation in response to stress;GO:0008643,carbohydrate transport	
IGHG4_HUMAN	P01861	IGHG4	Immunoglobulin heavy constant gamma 4	1.546874598	0.73687969	3.734168196	7.062906904	1.141877144	5.39853755	1.141877144	5.39853755	0.211516013999013	0.019241	-1	4.72777441808573	0.019363	1	GO:0072562,blood microparticle;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0042571,immunoglobulin complex, circulating;GO:0016021,integral component of membrane	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0019221,cytokine-mediated signaling pathway;GO:0042742,defense response to bacterium;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0045087,innate immune response;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0030449,regulation of complement activation	
JAM1_HUMAN	Q9Y624	F11R	Junctional adhesion molecule A	0.32278619	0.369507603	0.937004347	1.936771828	0.3461468965	1.4368880875	0.3461468965	1.4368880875	0.240900387101302	0.030680	-1	4.1510933711347	0.030845	1	GO:0005923,bicellular tight junction;GO:0030054,cell junction;GO:0005911,cell-cell junction;GO:0031410,cytoplasmic vesicle;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0036057,slit diaphragm;GO:0070160,tight junction	GO:0045296,cadherin binding;GO:0005178,integrin binding;GO:0030165,PDZ domain binding;GO:0042803,protein homodimerization activity;GO:0001618,virus receptor activity	GO:0031032,actomyosin structure organization;GO:0070830,bicellular tight junction assembly;GO:0098609,cell-cell adhesion;GO:0071260,cellular response to mechanical stimulus;GO:0090557,establishment of endothelial intestinal barrier;GO:0030198,extracellular matrix organization;GO:0006954,inflammatory response;GO:0050892,intestinal absorption;GO:0007159,leukocyte cell-cell adhesion;GO:0050900,leukocyte migration;GO:0035633,maintenance of blood-brain barrier;GO:0035683,memory T cell extravasation;GO:0034260,negative regulation of GTPase activity;GO:0051497,negative regulation of stress fiber assembly;GO:0045777,positive regulation of blood pressure;GO:1903142,positive regulation of establishment of endothelial barrier;GO:0043547,positive regulation of GTPase activity;GO:1901731,positive regulation of platelet aggregation;GO:0035025,positive regulation of Rho protein signal transduction;GO:1902396,protein localization to bicellular tight junction;GO:0072659,protein localization to plasma membrane;GO:0032956,regulation of actin cytoskeleton organization;GO:2000249,regulation of actin cytoskeleton reorganization;GO:2000810,regulation of bicellular tight junction assembly;GO:0008360,regulation of cell shape;GO:0001817,regulation of cytokine production;GO:0051493,regulation of cytoskeleton organization;GO:0090559,regulation of membrane permeability;GO:0009314,response to radiation;GO:0007179,transforming growth factor beta receptor signaling pathway;GO:0007155,cell adhesion	hsa:50848,path:hsa04514,Cell adhesion molecules (CAMs);hsa:50848,path:hsa04530,Tight junction;hsa:50848,path:hsa04670,Leukocyte transendothelial migration;hsa:50848,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection
COMT_HUMAN	P21964	COMT	Catechol O-methyltransferase	0.868661372	11.23290922	1.862744805	0.328305532	6.050785296	1.0955251685	6.050785296	1.0955251685	5.52318236949752	0.053889	0	0.181055039124297	0.053483	0	GO:0030424,axon;GO:0005829,cytosol;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0016206,catechol O-methyltransferase activity;GO:0102084,L-dopa O-methyltransferase activity;GO:0000287,magnesium ion binding;GO:0008171,O-methyltransferase activity;GO:0102938,orcinol O-methyltransferase activity	GO:0042424,catecholamine catabolic process;GO:0032502,developmental process;GO:0042417,dopamine metabolic process;GO:0032259,methylation;GO:0042135,neurotransmitter catabolic process;GO:0006584,catecholamine metabolic process	hsa:1312,path:hsa00140,Steroid hormone biosynthesis;hsa:1312,path:hsa00350,Tyrosine metabolism;hsa:1312,path:hsa04728,Dopaminergic synapse
RIR2B_HUMAN	Q7LG56	RRM2B	Ribonucleoside-diphosphate reductase subunit M2 B	0.285758078	0.472880352	0.420467744	0.252077197	0.379319215	0.3362724705	0.379319215	0.3362724705	1.12801150339781	0.393820	0	0.886515781964802	0.393540	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0016021,integral component of membrane;GO:0005739,mitochondrion	GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0004748,ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor;GO:0016491,oxidoreductase activity	GO:0009263,deoxyribonucleotide biosynthetic process;GO:0006281,DNA repair;GO:0006260,DNA replication;GO:0015949,nucleobase-containing small molecule interconversion;GO:0009200,deoxyribonucleoside triphosphate metabolic process;GO:0001822,kidney development;GO:0006264,mitochondrial DNA replication;GO:1902254,negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:0003014,renal system process;GO:0014075,response to amine;GO:0006979,response to oxidative stress	hsa:50484,path:hsa00230,Purine metabolism;hsa:50484,path:hsa00240,Pyrimidine metabolism;hsa:50484,path:hsa00480,Glutathione metabolism;hsa:50484,path:hsa00983,Drug metabolism - other enzymes;hsa:50484,path:hsa04115,p53 signaling pathway
PTN6_HUMAN	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	6.19258407	5.920235274	11.82446893	14.28019668	6.056409672	13.052332805	6.056409672	13.052332805	0.464009749251869	0.192394	0	2.15512713173013	0.192729	0	GO:0042105,alpha-beta T cell receptor complex;GO:0005911,cell-cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen	GO:0050839,cell adhesion molecule binding;GO:0140031,phosphorylation-dependent protein binding;GO:0001784,phosphotyrosine residue binding;GO:0019901,protein kinase binding;GO:0004725,protein tyrosine phosphatase activity;GO:0042169,SH2 domain binding;GO:0017124,SH3 domain binding;GO:0005001,transmembrane receptor protein tyrosine phosphatase activity	GO:0033277,abortive mitotic cell cycle;GO:0050853,B cell receptor signaling pathway;GO:0030154,cell differentiation;GO:0071345,cellular response to cytokine stimulus;GO:0019221,cytokine-mediated signaling pathway;GO:1905867,epididymis development;GO:0007186,G protein-coupled receptor signaling pathway;GO:0002244,hematopoietic progenitor cell differentiation;GO:0035556,intracellular signal transduction;GO:0050900,leukocyte migration;GO:0035855,megakaryocyte development;GO:0042267,natural killer cell mediated cytotoxicity;GO:0008285,negative regulation of cell population proliferation;GO:0002924,negative regulation of humoral immune response mediated by circulating immunoglobulin;GO:0032715,negative regulation of interleukin-6 production;GO:0043407,negative regulation of MAP kinase activity;GO:0050732,negative regulation of peptidyl-tyrosine phosphorylation;GO:0042130,negative regulation of T cell proliferation;GO:0050860,negative regulation of T cell receptor signaling pathway;GO:0032720,negative regulation of tumor necrosis factor production;GO:0043312,neutrophil degranulation;GO:0035335,peptidyl-tyrosine dephosphorylation;GO:0018108,peptidyl-tyrosine phosphorylation;GO:0030168,platelet activation;GO:0070527,platelet aggregation;GO:0030220,platelet formation;GO:0033630,positive regulation of cell adhesion mediated by integrin;GO:0008284,positive regulation of cell population proliferation;GO:0014068,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0006470,protein dephosphorylation;GO:0042981,regulation of apoptotic process;GO:0045577,regulation of B cell differentiation;GO:0070372,regulation of ERK1 and ERK2 cascade;GO:2000045,regulation of G1/S transition of mitotic cell cycle;GO:0051279,regulation of release of sequestered calcium ion into cytosol;GO:0060338,regulation of type I interferon-mediated signaling pathway;GO:0031295,T cell costimulation	hsa:5777,path:hsa04630,Jak-STAT signaling pathway;hsa:5777,path:hsa04520,Adherens junction;hsa:5777,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:5777,path:hsa04660,T cell receptor signaling pathway;hsa:5777,path:hsa04662,B cell receptor signaling pathway;hsa:5777,path:hsa05205,Proteoglycans in cancer;hsa:5777,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:5777,path:hsa05130,Pathogenic Escherichia coli infection;hsa:5777,path:hsa05140,Leishmaniasis
ERLN1_HUMAN	O75477	ERLIN1	Erlin-1	0.004651928	0.078892967	0.200229032	0.294153805	0.0417724475	0.2471914185	0.0417724475	0.2471914185	0.168988259193957	0.007917	-1	5.91757087012917	0.007982	1	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0032991,protein-containing complex	GO:0015485,cholesterol binding;GO:0031625,ubiquitin protein ligase binding	GO:0008203,cholesterol metabolic process;GO:0045541,negative regulation of cholesterol biosynthetic process;GO:0045717,negative regulation of fatty acid biosynthetic process;GO:0032933,SREBP signaling pathway;GO:0055085,transmembrane transport;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0008202,steroid metabolic process	
VAMP3_HUMAN	Q15836	VAMP3	Vesicle-associated membrane protein 3	0.286806411	0.75720917	0.106075806	0.331652342	0.5220077905	0.218864074	0.5220077905	0.218864074	2.3850775550308	0.183929	0	0.419273577872015	0.183362	0	GO:0016324,apical plasma membrane;GO:0009986,cell surface;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0030136,clathrin-coated vesicle;GO:0005829,cytosol;GO:0005769,early endosome;GO:0016021,integral component of membrane;GO:0030285,integral component of synaptic vesicle membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0043005,neuron projection;GO:0048471,perinuclear region of cytoplasm;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055037,recycling endosome;GO:0055038,recycling endosome membrane;GO:0030141,secretory granule;GO:0031201,SNARE complex;GO:0032588,trans-Golgi network membrane;GO:0030133,transport vesicle	GO:0005484,SNAP receptor activity;GO:0019905,syntaxin binding;GO:0017075,syntaxin-1 binding	GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0017156,calcium-ion regulated exocytosis;GO:0071346,cellular response to interferon-gamma;GO:0006887,exocytosis;GO:0043001,Golgi to plasma membrane protein transport;GO:0061025,membrane fusion;GO:0061024,membrane organization;GO:1903531,negative regulation of secretion by cell;GO:0001921,positive regulation of receptor recycling;GO:0065003,protein-containing complex assembly;GO:0042147,retrograde transport, endosome to Golgi;GO:0035493,SNARE complex assembly;GO:0034446,substrate adhesion-dependent cell spreading;GO:0006904,vesicle docking involved in exocytosis;GO:0006906,vesicle fusion;GO:0016192,vesicle-mediated transport	hsa:9341,path:hsa04130,SNARE interactions in vesicular transport;hsa:9341,path:hsa04145,Phagosome
PCCB_HUMAN	P05166	PCCB	Propionyl-CoA carboxylase beta chain, mitochondrial	0.213696339	0.450984774	0.676741509	0.600058227	0.3323405565	0.638399868	0.3323405565	0.638399868	0.520583686116928	0.244062	0	1.9209207408305	0.244383	0	GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0009317,acetyl-CoA carboxylase complex	GO:0005524,ATP binding;GO:0004658,propionyl-CoA carboxylase activity;GO:0016874,ligase activity;GO:0003989,acetyl-CoA carboxylase activity	GO:0006768,biotin metabolic process;GO:0019626,short-chain fatty acid catabolic process;GO:0006633,fatty acid biosynthetic process	hsa:5096,path:hsa00630,Glyoxylate and dicarboxylate metabolism;hsa:5096,path:hsa00640,Propanoate metabolism;hsa:5096,path:hsa00280,Valine, leucine and isoleucine degradation
HMGB2_HUMAN	P26583	HMGB2	High mobility group protein B2	2.846493628	3.340120024	0.636766654	0.270769095	3.093306826	0.4537678745	3.093306826	0.4537678745	6.81693658769579	0.037078	1	0.146693457850987	0.036746	-1	GO:0000785,chromatin;GO:0000793,condensed chromosome;GO:0005737,cytoplasm;GO:0005615,extracellular space;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0032991,protein-containing complex;GO:0005694,chromosome	GO:0042056,chemoattractant activity;GO:0000987,cis-regulatory region sequence-specific DNA binding;GO:0003684,damaged DNA binding;GO:0003677,DNA binding;GO:0008301,DNA binding, bending;GO:0003690,double-stranded DNA binding;GO:0000400,four-way junction DNA binding;GO:0044378,non-sequence-specific DNA binding, bending;GO:0019904,protein domain specific binding;GO:0050786,RAGE receptor binding;GO:0003723,RNA binding;GO:0003697,single-stranded DNA binding;GO:0097100,supercoiled DNA binding;GO:0003713,transcription coactivator activity;GO:0008134,transcription factor binding;GO:0000976,transcription regulatory region sequence-specific DNA binding	GO:0006309,apoptotic DNA fragmentation;GO:0060326,cell chemotaxis;GO:0071222,cellular response to lipopolysaccharide;GO:0006325,chromatin organization;GO:0050829,defense response to Gram-negative bacterium;GO:0050830,defense response to Gram-positive bacterium;GO:0032392,DNA geometric change;GO:0006265,DNA topological change;GO:0006303,double-strand break repair via nonhomologous end joining;GO:0002437,inflammatory response to antigenic stimulus;GO:0045087,innate immune response;GO:0008584,male gonad development;GO:1902042,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0010629,negative regulation of gene expression;GO:0045892,negative regulation of transcription, DNA-templated;GO:0006334,nucleosome assembly;GO:0043388,positive regulation of DNA binding;GO:0001938,positive regulation of endothelial cell proliferation;GO:0045648,positive regulation of erythrocyte differentiation;GO:0045089,positive regulation of innate immune response;GO:0032728,positive regulation of interferon-beta production;GO:0045654,positive regulation of megakaryocyte differentiation;GO:0032075,positive regulation of nuclease activity;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0050767,regulation of neurogenesis;GO:0072091,regulation of stem cell proliferation;GO:0006357,regulation of transcription by RNA polymerase II;GO:0032496,response to lipopolysaccharide;GO:0048545,response to steroid hormone;GO:0007289,spermatid nucleus differentiation;GO:0033151,V(D)J recombination	
TOM1_HUMAN	O60784	TOM1	Target of Myb protein 1	0.422200601	0.535880309	0.958080162	0.607905708	0.479040455	0.782992935	0.479040455	0.782992935	0.6118068677082	0.327603	0	1.63450273735232	0.327871	0	GO:0035577,azurophil granule membrane;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005769,early endosome;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0035579,specific granule membrane	GO:0030276,clathrin binding	GO:0006897,endocytosis;GO:0016197,endosomal transport;GO:0006886,intracellular protein transport;GO:0043312,neutrophil degranulation;GO:0015031,protein transport;GO:0007165,signal transduction	
ATM_HUMAN	Q13315	ATM	Serine-protein kinase ATM	0.063262975	0.132784633	0.16098706	0.047268324	0.098023804	0.104127692	0.098023804	0.104127692	0.94138074240616	0.453456	0	1.06226944630714	0.453303	0	GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:1990391,DNA repair complex;GO:0043231,intracellular membrane-bounded organelle;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005782,peroxisomal matrix;GO:0005819,spindle	GO:0016303,1-phosphatidylinositol-3-kinase activity;GO:0005524,ATP binding;GO:0003677,DNA binding;GO:0004677,DNA-dependent protein kinase activity;GO:0042802,identical protein binding;GO:0047485,protein N-terminus binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0044877,protein-containing complex binding	GO:0007420,brain development;GO:0007050,cell cycle arrest;GO:0006974,cellular response to DNA damage stimulus;GO:0071480,cellular response to gamma radiation;GO:0071500,cellular response to nitrosative stress;GO:0071300,cellular response to retinoic acid;GO:0071481,cellular response to X-ray;GO:0008340,determination of adult lifespan;GO:0000077,DNA damage checkpoint;GO:0006975,DNA damage induced protein phosphorylation;GO:0006977,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0000729,DNA double-strand break processing;GO:0006260,DNA replication;GO:0006302,double-strand break repair;GO:0000724,double-strand break repair via homologous recombination;GO:0006303,double-strand break repair via nonhomologous end joining;GO:0097695,establishment of protein-containing complex localization to telomere;GO:0097694,establishment of RNA localization to telomere;GO:0007143,female meiotic nuclear division;GO:0007507,heart development;GO:0071044,histone mRNA catabolic process;GO:0016572,histone phosphorylation;GO:0008630,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0042159,lipoprotein catabolic process;GO:0007140,male meiotic nuclear division;GO:0045141,meiotic telomere clustering;GO:0007094,mitotic spindle assembly checkpoint;GO:0035264,multicellular organism growth;GO:0030889,negative regulation of B cell proliferation;GO:1904354,negative regulation of telomere capping;GO:1904262,negative regulation of TORC1 signaling;GO:0051402,neuron apoptotic process;GO:0048599,oocyte development;GO:0001541,ovarian follicle development;GO:0036289,peptidyl-serine autophosphorylation;GO:0018105,peptidyl-serine phosphorylation;GO:0000425,pexophagy;GO:0043065,positive regulation of apoptotic process;GO:0045785,positive regulation of cell adhesion;GO:0030335,positive regulation of cell migration;GO:1903626,positive regulation of DNA catabolic process;GO:0043517,positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0010628,positive regulation of gene expression;GO:0033129,positive regulation of histone phosphorylation;GO:0043525,positive regulation of neuron apoptotic process;GO:1904884,positive regulation of telomerase catalytic core complex assembly;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:1904358,positive regulation of telomere maintenance via telomere lengthening;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0009791,post-embryonic development;GO:0002331,pre-B cell allelic exclusion;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:0007131,reciprocal meiotic recombination;GO:0042981,regulation of apoptotic process;GO:0010506,regulation of autophagy;GO:1905843,regulation of cellular response to gamma radiation;GO:1900034,regulation of cellular response to heat;GO:1903978,regulation of microglial cell activation;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0032210,regulation of telomere maintenance via telomerase;GO:0090399,replicative senescence;GO:0001666,response to hypoxia;GO:0010212,response to ionizing radiation;GO:0007165,signal transduction;GO:0072434,signal transduction involved in mitotic G2 DNA damage checkpoint;GO:0001756,somitogenesis;GO:0000723,telomere maintenance;GO:0048538,thymus development;GO:0033151,V(D)J recombination;GO:0006281,DNA repair	hsa:472,path:hsa03440,Homologous recombination;hsa:472,path:hsa04064,NF-kappa B signaling pathway;hsa:472,path:hsa04068,FoxO signaling pathway;hsa:472,path:hsa04110,Cell cycle;hsa:472,path:hsa04210,Apoptosis;hsa:472,path:hsa04115,p53 signaling pathway;hsa:472,path:hsa04218,Cellular senescence;hsa:472,path:hsa05202,Transcriptional misregulation in cancer;hsa:472,path:hsa05206,MicroRNAs in cancer;hsa:472,path:hsa05131,Shigellosis;hsa:472,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:472,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:472,path:hsa05165,Human papillomavirus infection;hsa:472,path:hsa01524,Platinum drug resistance
PDIA4_HUMAN	P13667	PDIA4	Protein disulfide-isomerase A4	32.48322228	27.47320847	43.43549695	26.90435661	29.978215375	35.16992678	29.978215375	35.16992678	0.852382080933067	0.486747	0	1.17318280424823	0.486667	0	GO:0009986,cell surface;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005615,extracellular space;GO:0042470,melanosome	GO:0015037,peptide disulfide oxidoreductase activity;GO:0003756,protein disulfide isomerase activity;GO:0003723,RNA binding	GO:0061077,chaperone-mediated protein folding;GO:0006457,protein folding;GO:0009306,protein secretion;GO:0034976,response to endoplasmic reticulum stress	hsa:9601,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:9601,path:hsa04918,Thyroid hormone synthesis;hsa:9601,path:hsa05110,Vibrio cholerae infection
PGAM1_HUMAN	P18669	PGAM1	Phosphoglycerate mutase 1	22.43551646	28.26735877	21.88721683	133.9217596	25.351437615	77.904488215	25.351437615	77.904488215	0.325416907239482	0.079075	0	3.07298108289154	0.079348	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0034774,secretory granule lumen	GO:0004082,bisphosphoglycerate mutase activity;GO:0016787,hydrolase activity;GO:0004619,phosphoglycerate mutase activity;GO:0019901,protein kinase binding	GO:0061621,canonical glycolysis;GO:0006094,gluconeogenesis;GO:0006096,glycolytic process;GO:0043312,neutrophil degranulation;GO:0006110,regulation of glycolytic process;GO:0043456,regulation of pentose-phosphate shunt;GO:0045730,respiratory burst	hsa:5223,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:5223,path:hsa00260,Glycine, serine and threonine metabolism;hsa:5223,path:hsa04922,Glucagon signaling pathway;hsa:5223,path:hsa05230,Central carbon metabolism in cancer
LAMC2_HUMAN	Q13753	LAMC2	Laminin subunit gamma-2	0.746969869	0.926945965	1.175807711	5.411928616	0.836957917	3.2938681635	0.836957917	3.2938681635	0.254095754734356	0.036776	-1	3.9355242319788	0.036960	1	GO:0005604,basement membrane;GO:0005938,cell cortex;GO:0062023,collagen-containing extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005607,laminin-2 complex;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm	GO:0008201,heparin binding;GO:0005102,signaling receptor binding	GO:0009887,animal organ morphogenesis;GO:0007155,cell adhesion;GO:0030199,collagen fibril organization;GO:0016358,dendrite development;GO:0008544,epidermis development;GO:0030198,extracellular matrix organization;GO:0031581,hemidesmosome assembly;GO:0008045,motor neuron axon guidance;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0009888,tissue development	hsa:3918,path:hsa04151,PI3K-Akt signaling pathway;hsa:3918,path:hsa04512,ECM-receptor interaction;hsa:3918,path:hsa04510,Focal adhesion;hsa:3918,path:hsa05200,Pathways in cancer;hsa:3918,path:hsa05222,Small cell lung cancer;hsa:3918,path:hsa05165,Human papillomavirus infection;hsa:3918,path:hsa05146,Amoebiasis;hsa:3918,path:hsa05145,Toxoplasmosis
TAP2_HUMAN	Q03519	TAP2	Antigen peptide transporter 2	2.592662677	1.76384874	4.152727663	3.146800624	2.1782557085	3.6497641435	2.1782557085	3.6497641435	0.596820951397458	0.314037	0	1.67554439511297	0.314315	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0042824,MHC class I peptide loading complex;GO:0016607,nuclear speck;GO:0030670,phagocytic vesicle membrane;GO:0042825,TAP complex	GO:0015433,ABC-type peptide antigen transporter activity;GO:0015440,ABC-type peptide transporter activity;GO:0005524,ATP binding;GO:0042626,ATPase-coupled transmembrane transporter activity;GO:0046872,metal ion binding;GO:0023029,MHC class Ib protein binding;GO:0042605,peptide antigen binding;GO:0046978,TAP1 binding;GO:0046980,tapasin binding;GO:0042287,MHC protein binding	GO:0002250,adaptive immune response;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002489,antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0046967,cytosol to endoplasmic reticulum transport;GO:0046968,peptide antigen transport;GO:0015833,peptide transport;GO:0015031,protein transport;GO:0055085,transmembrane transport;GO:1990668,vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane;GO:0016032,viral process	hsa:6891,path:hsa02010,ABC transporters;hsa:6891,path:hsa04145,Phagosome;hsa:6891,path:hsa04612,Antigen processing and presentation;hsa:6891,path:hsa05340,Primary immunodeficiency;hsa:6891,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:6891,path:hsa05168,Herpes simplex virus 1 infection;hsa:6891,path:hsa05163,Human cytomegalovirus infection;hsa:6891,path:hsa05169,Epstein-Barr virus infection
HMGB3_HUMAN	O15347	HMGB3	High mobility group protein B3	1.696786506	1.885875594	0.269390688	0.33530648	1.79133105	0.302348584	1.79133105	0.302348584	5.92472114901653	0.047716	1	0.168784314881384	0.047335	-1	GO:0005694,chromosome;GO:0005737,cytoplasm;GO:0005634,nucleus	GO:0008301,DNA binding, bending;GO:0003690,double-stranded DNA binding;GO:0000400,four-way junction DNA binding;GO:0003723,RNA binding;GO:0003677,DNA binding	GO:0032392,DNA geometric change;GO:0006310,DNA recombination;GO:0045087,innate immune response;GO:0007275,multicellular organism development;GO:0045578,negative regulation of B cell differentiation;GO:0045638,negative regulation of myeloid cell differentiation;GO:0006357,regulation of transcription by RNA polymerase II	
NDK3_HUMAN	Q13232	NME3	Nucleoside diphosphate kinase 3	1.061834044	3.532869799	0.140087384	0.591996835	2.2973519215	0.3660421095	2.2973519215	0.3660421095	6.27619572141057	0.043082	1	0.159332188540362	0.042721	-1	GO:0005829,cytosol	GO:0005524,ATP binding;GO:0046872,metal ion binding;GO:0004550,nucleoside diphosphate kinase activity	GO:0006915,apoptotic process;GO:0006241,CTP biosynthetic process;GO:0006183,GTP biosynthetic process;GO:0015949,nucleobase-containing small molecule interconversion;GO:0006228,UTP biosynthetic process	hsa:4832,path:hsa00230,Purine metabolism;hsa:4832,path:hsa00240,Pyrimidine metabolism;hsa:4832,path:hsa00983,Drug metabolism - other enzymes
ACPH_HUMAN	P13798	APEH	Acylamino-acid-releasing enzyme	1.150319704	2.129706148	3.001520512	6.043237659	1.640012926	4.5223790855	1.640012926	4.5223790855	0.36264384187923	0.106421	0	2.75752648884915	0.106725	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0031965,nuclear membrane	GO:0042802,identical protein binding;GO:0008242,omega peptidase activity;GO:0003723,RNA binding;GO:0004252,serine-type endopeptidase activity	GO:0050435,amyloid-beta metabolic process;GO:0043312,neutrophil degranulation;GO:0006508,proteolysis;GO:0006415,translational termination	
A2AP_HUMAN	P08697	SERPINF2	Alpha-2-antiplasmin	0.800925335	0.567658872	1.343268892	4.730379786	0.6842921035	3.036824339	0.6842921035	3.036824339	0.225331473642407	0.024248	-1	4.43790644882109	0.024391	1	GO:0072562,blood microparticle;GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005577,fibrinogen complex;GO:0031093,platelet alpha granule lumen	GO:0004866,endopeptidase inhibitor activity;GO:0002020,protease binding;GO:0042803,protein homodimerization activity;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0006953,acute-phase response;GO:0048514,blood vessel morphogenesis;GO:0030199,collagen fibril organization;GO:0042730,fibrinolysis;GO:0002034,maintenance of blood vessel diameter homeostasis by renin-angiotensin;GO:0010951,negative regulation of endopeptidase activity;GO:0051918,negative regulation of fibrinolysis;GO:0010757,negative regulation of plasminogen activation;GO:0002576,platelet degranulation;GO:0045597,positive regulation of cell differentiation;GO:2000049,positive regulation of cell-cell adhesion mediated by cadherin;GO:0032967,positive regulation of collagen biosynthetic process;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0046330,positive regulation of JNK cascade;GO:0048661,positive regulation of smooth muscle cell proliferation;GO:0051496,positive regulation of stress fiber assembly;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0071636,positive regulation of transforming growth factor beta production;GO:0010033,response to organic substance	hsa:5345,path:hsa04610,Complement and coagulation cascades
FUCO_HUMAN	P04066	FUCA1	Tissue alpha-L-fucosidase	0.67781173	0.735444302	1.518625583	1.000350341	0.706628016	1.259487962	0.706628016	1.259487962	0.561043882370985	0.281324	0	1.78239177259001	0.281626	0	GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0043202,lysosomal lumen;GO:0005764,lysosome	GO:0004560,alpha-L-fucosidase activity	GO:0006004,fucose metabolic process;GO:0019377,glycolipid catabolic process;GO:0006027,glycosaminoglycan catabolic process;GO:0016139,glycoside catabolic process;GO:0043312,neutrophil degranulation	hsa:2517,path:hsa00511,Other glycan degradation;hsa:2517,path:hsa04142,Lysosome
PIR_HUMAN	O00625	PIR	Pirin	0.127179536	0.06924337	0.101678813	0.151795293	0.098211453	0.126737053	0.098211453	0.126737053	0.774922965898536	0.465991	0	1.2904508499635	0.466120	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0046872,metal ion binding;GO:0008127,quercetin 2,3-dioxygenase activity;GO:0003712,transcription coregulator activity	GO:0007586,digestion;GO:0030224,monocyte differentiation;GO:0006366,transcription by RNA polymerase II	
RMD3_HUMAN	Q96TC7	RMDN3	Regulator of microtubule dynamics protein 3	5.227488201	5.849311934	5.262669658	18.60899517	5.5384000675	11.935832414	5.5384000675	11.935832414	0.464014563492346	0.192398	0	2.15510477187101	0.192733	0	GO:0005737,cytoplasm;GO:0016021,integral component of membrane;GO:0045171,intercellular bridge;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0097431,mitotic spindle pole;GO:0005634,nucleus;GO:0044232,organelle membrane contact site;GO:0005876,spindle microtubule	GO:0008017,microtubule binding	GO:0006915,apoptotic process;GO:0030154,cell differentiation;GO:0006874,cellular calcium ion homeostasis	
ARF3_HUMAN	P61204	ARF3	ADP-ribosylation factor 3	17.37029197	26.51547806	2.761572191	1.125270602	21.942885015	1.9434213965	21.942885015	1.9434213965	11.2908528508115	0.013520	1	0.0885672688514519	0.013346	-1	GO:0070062,extracellular exosome;GO:0000139,Golgi membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane	GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0006886,intracellular protein transport;GO:0006661,phosphatidylinositol biosynthetic process;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0016192,vesicle-mediated transport	hsa:377,path:hsa04144,Endocytosis
XPP3_HUMAN	Q9NQH7	XPNPEP3	Xaa-Pro aminopeptidase 3	2.55E-05	0.010895528	0.022815989	2.55E-05	0.005460514	0.0114207445	0.005460514	0.0114207445	0.47812242012769	0.205162	0	2.09151455339186	0.205496	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005739,mitochondrion	GO:0004177,aminopeptidase activity;GO:0030145,manganese ion binding;GO:0070006,metalloaminopeptidase activity;GO:0008233,peptidase activity;GO:0042803,protein homodimerization activity	GO:0003094,glomerular filtration;GO:0016485,protein processing;GO:0006508,proteolysis	
CNN1_HUMAN	P51911	CNN1	Calponin-1	3.197097127	2.440354318	0.690183498	4.621958323	2.8187257225	2.6560709105	2.8187257225	2.6560709105	1.06123888159649	0.413736	0	0.94229491337109	0.413497	0	GO:0005856,cytoskeleton;GO:0005925,focal adhesion	GO:0003779,actin binding;GO:0005516,calmodulin binding	GO:0031032,actomyosin structure organization;GO:1904706,negative regulation of vascular associated smooth muscle cell proliferation;GO:0006940,regulation of smooth muscle contraction	
SRXN1_HUMAN	Q9BYN0	SRXN1	Sulfiredoxin-1	0.321591625	0.572370268	0.749199112	0.633987025	0.4469809465	0.6915930685	0.4469809465	0.6915930685	0.646306284517078	0.358412	0	1.54725402484242	0.358652	0	GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0005524,ATP binding;GO:0016667,oxidoreductase activity, acting on a sulfur group of donors;GO:0032542,sulfiredoxin activity	GO:0034599,cellular response to oxidative stress;GO:0006979,response to oxidative stress	
SNR40_HUMAN	Q96DI7	SNRNP40	U5 small nuclear ribonucleoprotein 40 kDa protein	0.19881336	0.083559486	0.261210374	0.274542438	0.141186423	0.267876406	0.141186423	0.267876406	0.527058075431996	0.250026	0	1.89732412159773	0.250345	0	GO:0071013,catalytic step 2 spliceosome;GO:0005829,cytosol;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005732,sno(s)RNA-containing ribonucleoprotein complex;GO:0071007,U2-type catalytic step 2 spliceosome;GO:0005682,U5 snRNP;GO:0016021,integral component of membrane	GO:0003723,RNA binding	GO:0000398,mRNA splicing, via spliceosome;GO:0006396,RNA processing;GO:0008380,RNA splicing;GO:0000375,RNA splicing, via transesterification reactions	hsa:9410,path:hsa03040,Spliceosome
CBPB2_HUMAN	Q96IY4	CPB2	Carboxypeptidase B2	0.396897514	0.113496755	0.208608721	0.704058323	0.2551971345	0.456333522	0.2551971345	0.456333522	0.559233810791573	0.279661	0	1.78816083845957	0.279963	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0004181,metallocarboxypeptidase activity;GO:0008270,zinc ion binding	GO:0007596,blood coagulation;GO:0071333,cellular response to glucose stimulus;GO:0042730,fibrinolysis;GO:0097421,liver regeneration;GO:0051918,negative regulation of fibrinolysis;GO:2000346,negative regulation of hepatocyte proliferation;GO:0010757,negative regulation of plasminogen activation;GO:0003331,positive regulation of extracellular matrix constituent secretion;GO:0006508,proteolysis;GO:0030449,regulation of complement activation;GO:0042493,response to drug;GO:0009408,response to heat	hsa:1361,path:hsa04610,Complement and coagulation cascades;hsa:1361,path:hsa04972,Pancreatic secretion;hsa:1361,path:hsa04974,Protein digestion and absorption
MTND_HUMAN	Q9BV57	ADI1	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase	0.585420289	0.348446451	0.033198861	2.55E-05	0.46693337	0.0166121805	0.46693337	0.0166121805	28.1078916762312	0.001443	1	0.035577197020637	0.001411	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0010309,acireductone dioxygenase [iron(II)-requiring] activity;GO:0005506,iron ion binding;GO:0016491,oxidoreductase activity	GO:0019509,L-methionine salvage from methylthioadenosine;GO:0006555,methionine metabolic process;GO:0009086,methionine biosynthetic process	hsa:55256,path:hsa00270,Cysteine and methionine metabolism
MIF_HUMAN	P14174	MIF	Macrophage migration inhibitory factor	4.533134137	0.661214345	0.04586961	2.55E-05	2.597174241	0.022947555	2.597174241	0.022947555	113.178691193898	0.000016	1	0.00883558547506786	0.000016	-1	GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0034774,secretory granule lumen;GO:0031982,vesicle	GO:0042056,chemoattractant activity;GO:0005125,cytokine activity;GO:0005126,cytokine receptor binding;GO:0004167,dopachrome isomerase activity;GO:0042802,identical protein binding;GO:0050178,phenylpyruvate tautomerase activity	GO:0019752,carboxylic acid metabolic process;GO:0007166,cell surface receptor signaling pathway;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0035722,interleukin-12-mediated signaling pathway;GO:0050900,leukocyte migration;GO:0043066,negative regulation of apoptotic process;GO:0090344,negative regulation of cell aging;GO:0071157,negative regulation of cell cycle arrest;GO:0030336,negative regulation of cell migration;GO:0043518,negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0010629,negative regulation of gene expression;GO:1902166,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0010760,negative regulation of macrophage chemotaxis;GO:0043312,neutrophil degranulation;GO:0030890,positive regulation of B cell proliferation;GO:0001819,positive regulation of cytokine production;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0048146,positive regulation of fibroblast proliferation;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0042327,positive regulation of phosphorylation;GO:0010739,positive regulation of protein kinase A signaling;GO:0032760,positive regulation of tumor necrosis factor production;GO:0001516,prostaglandin biosynthetic process;GO:0070207,protein homotrimerization;GO:0043030,regulation of macrophage activation	hsa:4282,path:hsa00350,Tyrosine metabolism;hsa:4282,path:hsa00360,Phenylalanine metabolism
CDC5L_HUMAN	Q99459	CDC5L	Cell division cycle 5-like protein	0.12549183	0.063745627	0.160987171	0.089067766	0.0946187285	0.1250274685	0.0946187285	0.1250274685	0.756783526333655	0.451628	0	1.32138182875708	0.451773	0	GO:0071013,catalytic step 2 spliceosome;GO:0005737,cytoplasm;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0032993,protein-DNA complex;GO:0000974,Prp19 complex;GO:0005681,spliceosomal complex;GO:0071007,U2-type catalytic step 2 spliceosome	GO:0003677,DNA binding;GO:0001228,DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043522,leucine zipper domain binding;GO:0019901,protein kinase binding;GO:0008157,protein phosphatase 1 binding;GO:0003723,RNA binding;GO:0000977,RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001222,transcription corepressor binding;GO:0071987,WD40-repeat domain binding	GO:0044344,cellular response to fibroblast growth factor stimulus;GO:0071352,cellular response to interleukin-2;GO:1990090,cellular response to nerve growth factor stimulus;GO:1990646,cellular response to prolactin;GO:1904568,cellular response to wortmannin;GO:0006281,DNA repair;GO:0000278,mitotic cell cycle;GO:0000398,mRNA splicing, via spliceosome;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0006357,regulation of transcription by RNA polymerase II;GO:0072422,signal transduction involved in DNA damage checkpoint	hsa:988,path:hsa03040,Spliceosome
RANG_HUMAN	P43487	RANBP1	Ran-specific GTPase-activating protein	1.174553848	0.019143141	0.340172839	0.832865597	0.5968484945	0.586519218	0.5968484945	0.586519218	1.01761114756857	0.427570	0	0.982693637338144	0.427361	0	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005635,nuclear envelope;GO:0005643,nuclear pore;GO:0005634,nucleus;GO:1904115,axon cytoplasm	GO:0045296,cadherin binding;GO:0005092,GDP-dissociation inhibitor activity;GO:0005096,GTPase activator activity;GO:0031267,small GTPase binding	GO:0046907,intracellular transport;GO:0043547,positive regulation of GTPase activity;GO:0046604,positive regulation of mitotic centrosome separation;GO:0007165,signal transduction;GO:0016032,viral process;GO:0035690,cellular response to drug;GO:0072750,cellular response to leptomycin B;GO:0010976,positive regulation of neuron projection development;GO:0051592,response to calcium ion;GO:0007051,spindle organization	hsa:5902,path:hsa05203,Viral carcinogenesis;hsa:5902,path:hsa05166,Human T-cell leukemia virus 1 infection
PLGT3_HUMAN	Q7Z4H8	POGLUT3	Protein O-glucosyltransferase 3	0.276409917	0.41082854	0.286495024	0.724739796	0.3436192285	0.50561741	0.3436192285	0.50561741	0.679603236961322	0.387463	0	1.47144678779232	0.387676	0	GO:0012505,endomembrane system;GO:0005788,endoplasmic reticulum lumen	GO:0140561,EGF-domain serine glucosyltransferase activity;GO:0140562,EGF-domain serine xylosyltransferase activity;GO:0046527,glucosyltransferase activity;GO:0035251,UDP-glucosyltransferase activity;GO:0035252,UDP-xylosyltransferase activity;GO:0016757,transferase activity, transferring glycosyl groups	GO:0018242,protein O-linked glycosylation via serine;GO:0006486,protein glycosylation	
WDR91_HUMAN	A4D1P6	WDR91	WD repeat-containing protein 91	0.077971633	0.120586742	0.313990312	0.256382777	0.0992791875	0.2851865445	0.0992791875	0.2851865445	0.348120167008791	0.095393	0	2.8725712979873	0.095687	0	GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0031313,extrinsic component of endosome membrane;GO:0031902,late endosome membrane	GO:0035014,phosphatidylinositol 3-kinase regulator activity	GO:0045022,early endosome to late endosome transport;GO:1903362,regulation of cellular protein catabolic process;GO:0043551,regulation of phosphatidylinositol 3-kinase activity	
SAMH1_HUMAN	Q9Y3Z3	SAMHD1	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	12.6503781	18.0053438	23.72187281	20.82709845	15.32786095	22.27448563	15.32786095	22.27448563	0.68813534932344	0.394784	0	1.45320248550402	0.394990	0	GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0035861,site of double-strand break;GO:0097197,tetraspanin-enriched microdomain;GO:0005694,chromosome	GO:0032567,dGTP binding;GO:0008832,dGTPase activity;GO:0005525,GTP binding;GO:0042802,identical protein binding;GO:0003676,nucleic acid binding;GO:0004540,ribonuclease activity;GO:0003723,RNA binding;GO:0003697,single-stranded DNA binding;GO:0016793,triphosphoric monoester hydrolase activity;GO:0008270,zinc ion binding;GO:0003824,catalytic activity	GO:0006974,cellular response to DNA damage stimulus;GO:0046061,dATP catabolic process;GO:0051607,defense response to virus;GO:0009264,deoxyribonucleotide catabolic process;GO:0006203,dGTP catabolic process;GO:0110025,DNA strand resection involved in replication fork processing;GO:0000724,double-strand break repair via homologous recombination;GO:0006955,immune response;GO:0060339,negative regulation of type I interferon-mediated signaling pathway;GO:0051289,protein homotetramerization;GO:0045088,regulation of innate immune response;GO:0016446,somatic hypermutation of immunoglobulin genes;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process;GO:0006281,DNA repair;GO:0006260,DNA replication	hsa:25939,path:hsa05170,Human immunodeficiency virus 1 infection
RBP2_HUMAN	P49792	RANBP2	E3 SUMO-protein ligase RanBP2	1.374440142	1.467704978	1.881131042	1.243391208	1.42107256	1.562261125	1.42107256	1.562261125	0.909625501946738	0.464934	0	1.09935352280675	0.464806	0	GO:0005642,annulate lamellae;GO:0005737,cytoplasm;GO:1990723,cytoplasmic periphery of the nuclear pore complex;GO:0005829,cytosol;GO:0043657,host cell;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005635,nuclear envelope;GO:0042405,nuclear inclusion body;GO:0031965,nuclear membrane;GO:0005643,nuclear pore;GO:0044614,nuclear pore cytoplasmic filaments;GO:0044615,nuclear pore nuclear basket;GO:0005654,nucleoplasm	GO:0046872,metal ion binding;GO:0044877,protein-containing complex binding;GO:0003723,RNA binding;GO:0031267,small GTPase binding;GO:0019789,SUMO transferase activity	GO:0051642,centrosome localization;GO:0075733,intracellular transport of virus;GO:0007052,mitotic spindle organization;GO:0006406,mRNA export from nucleus;GO:0006607,NLS-bearing protein import into nucleus;GO:0033133,positive regulation of glucokinase activity;GO:0043547,positive regulation of GTPase activity;GO:0006457,protein folding;GO:0000413,protein peptidyl-prolyl isomerization;GO:0016925,protein sumoylation;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006111,regulation of gluconeogenesis;GO:0006110,regulation of glycolytic process;GO:0001975,response to amphetamine;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription	hsa:5903,path:hsa03013,RNA transport
ZFY27_HUMAN	Q5T4F4	ZFYVE27	Protrudin	2.042367255	2.55E-05	0.585437747	3.454089442	1.0211963775	2.0197635945	1.0211963775	2.0197635945	0.505601932959288	0.230281	0	1.97784053978394	0.230608	0	GO:0030424,axon;GO:0005829,cytosol;GO:0030425,dendrite;GO:0005783,endoplasmic reticulum;GO:0071782,endoplasmic reticulum tubular network;GO:0032584,growth cone membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005654,nucleoplasm;GO:0055038,recycling endosome membrane	GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0043621,protein self-association	GO:0071787,endoplasmic reticulum tubular network formation;GO:0031175,neuron projection development;GO:0048011,neurotrophin TRK receptor signaling pathway;GO:0045773,positive regulation of axon extension;GO:0072659,protein localization to plasma membrane;GO:0016192,vesicle-mediated transport	hsa:118813,path:hsa04144,Endocytosis
IN35_HUMAN	P80217	IFI35	Interferon-induced 35 kDa protein	0.323731613	0.207588399	0.110207129	2.55E-05	0.265660006	0.0551163145	0.265660006	0.0551163145	4.81998857162338	0.067656	0	0.207469371584671	0.067204	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005615,extracellular space;GO:0016020,membrane;GO:0005634,nucleus	GO:0042802,identical protein binding	GO:0002281,macrophage activation involved in immune response;GO:0008285,negative regulation of cell population proliferation;GO:1901223,negative regulation of NIK/NF-kappaB signaling;GO:0050729,positive regulation of inflammatory response;GO:0045089,positive regulation of innate immune response;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:0034145,positive regulation of toll-like receptor 4 signaling pathway;GO:0060337,type I interferon signaling pathway	
SPB13_HUMAN	Q9UIV8	SERPINB13	Serpin B13	2.55E-05	0.021757218	0.089673057	0.185403871	0.010891359	0.137538464	0.010891359	0.137538464	0.0791877318042464	0.000178	-1	12.6282187558045	0.000181	1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0043202,lysosomal lumen;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0016021,integral component of membrane	GO:0004869,cysteine-type endopeptidase inhibitor activity;GO:0002020,protease binding;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0010951,negative regulation of endopeptidase activity;GO:1902173,negative regulation of keratinocyte apoptotic process;GO:0045616,regulation of keratinocyte differentiation;GO:0030162,regulation of proteolysis;GO:0009411,response to UV	hsa:5275,path:hsa05146,Amoebiasis
HV103_HUMAN	A0A0C4DH29	IGHV1-3	Immunoglobulin heavy variable 1-3	0.072903886	0.046726458	0.176770024	0.370933833	0.059815172	0.2738519285	0.059815172	0.2738519285	0.218421583983843	0.021661	-1	4.57830211538972	0.021794	1	GO:0009897,external side of plasma membrane;GO:0042571,immunoglobulin complex, circulating;GO:0005576,extracellular region;GO:0005886,plasma membrane;GO:0019814,immunoglobulin complex	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006956,complement activation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
LEG1_HUMAN	P09382	LGALS1	Galectin-1	35.40292347	66.4123079	15.49092541	25.57989546	50.907615685	20.535410435	50.907615685	20.535410435	2.47901622644145	0.175397	0	0.403385822704142	0.174827	0	GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005634,nucleus	GO:0030246,carbohydrate binding;GO:0042802,identical protein binding;GO:0030395,lactose binding;GO:0043236,laminin binding;GO:0003723,RNA binding	GO:0006915,apoptotic process;GO:0044267,cellular protein metabolic process;GO:0071333,cellular response to glucose stimulus;GO:0071407,cellular response to organic cyclic compound;GO:0045445,myoblast differentiation;GO:0010812,negative regulation of cell-substrate adhesion;GO:0010977,negative regulation of neuron projection development;GO:0002317,plasma cell differentiation;GO:0034120,positive regulation of erythrocyte aggregation;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046598,positive regulation of viral entry into host cell;GO:0043687,post-translational protein modification;GO:0042981,regulation of apoptotic process;GO:0048678,response to axon injury;GO:0042493,response to drug;GO:0035900,response to isolation stress;GO:0031295,T cell costimulation	
TDR15_HUMAN	B5MCY1	TDRD15	Tudor domain-containing protein 15	2.838372228	4.089745843	2.623263764	2.049701436	3.4640590355	2.3364826	3.4640590355	2.3364826	1.48259569127542	0.308621	0	0.674492719683905	0.308184	0				
VIME_HUMAN	P08670	VIM	Vimentin	251.4142015	853.699726	424.1299049	451.2888206	552.55696375	437.70936275	552.55696375	437.70936275	1.2623832405102	0.357841	0	0.792152468370733	0.357490	0	GO:0031252,cell leading edge;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005882,intermediate filament;GO:0045111,intermediate filament cytoskeleton;GO:0005815,microtubule organizing center;GO:0043005,neuron projection;GO:0016363,nuclear matrix;GO:0005777,peroxisome;GO:0045335,phagocytic vesicle;GO:0005886,plasma membrane;GO:0005844,polysome;GO:1990904,ribonucleoprotein complex	GO:0003725,double-stranded RNA binding;GO:0042802,identical protein binding;GO:1990254,keratin filament binding;GO:0019904,protein domain specific binding;GO:0097110,scaffold protein binding;GO:0005200,structural constituent of cytoskeleton;GO:0005212,structural constituent of eye lens	GO:0035973,aggrephagy;GO:0014002,astrocyte development;GO:0060020,Bergmann glial cell differentiation;GO:0071346,cellular response to interferon-gamma;GO:0071222,cellular response to lipopolysaccharide;GO:0071225,cellular response to muramyl dipeptide;GO:0019221,cytokine-mediated signaling pathway;GO:0045109,intermediate filament organization;GO:0070307,lens fiber cell development;GO:0030049,muscle filament sliding;GO:0010977,negative regulation of neuron projection development;GO:0032967,positive regulation of collagen biosynthetic process;GO:0045727,positive regulation of translation;GO:0043488,regulation of mRNA stability;GO:0060395,SMAD protein signal transduction;GO:0016032,viral process	hsa:7431,path:hsa05206,MicroRNAs in cancer;hsa:7431,path:hsa05169,Epstein-Barr virus infection
CAF17_HUMAN	Q5T440	IBA57	Putative transferase CAF17, mitochondrial	0.063885055	0.045169309	0.182653782	2.55E-05	0.054527182	0.091339641	0.054527182	0.091339641	0.596971713519216	0.314174	0	1.67512124503335	0.314452	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0003723,RNA binding;GO:0016740,transferase activity	GO:0006783,heme biosynthetic process;GO:0016226,iron-sulfur cluster assembly	
RB22A_HUMAN	Q9UL26	RAB22A	Ras-related protein Rab-22A	0.051311547	0.187849264	0.004242866	0.005545726	0.1195804055	0.004894296	0.1195804055	0.004894296	24.4326059355625	0.002108	1	0.0409289128894951	0.002065	-1	GO:0015629,actin cytoskeleton;GO:0005769,early endosome;GO:0012505,endomembrane system;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0005770,late endosome;GO:0045335,phagocytic vesicle;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0001726,ruffle	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0006897,endocytosis;GO:0007032,endosome organization;GO:0006886,intracellular protein transport;GO:0097494,regulation of vesicle size	hsa:57403,path:hsa04144,Endocytosis
DCTN4_HUMAN	Q9UJW0	DCTN4	Dynactin subunit 4	0.148213208	0.177076905	0.159653464	0.105544534	0.1626450565	0.132598999	0.1626450565	0.132598999	1.22659339607835	0.366930	0	0.815266088336352	0.366597	0	GO:0005938,cell cortex;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005868,cytoplasmic dynein complex;GO:0005829,cytosol;GO:0005869,dynactin complex;GO:0005925,focal adhesion;GO:0000776,kinetochore;GO:0005634,nucleus;GO:0030017,sarcomere;GO:0000922,spindle pole;GO:0001725,stress fiber	GO:0047485,protein N-terminus binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport	hsa:51164,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:51164,path:hsa05016,Huntington disease
SNRPA_HUMAN	P09012	SNRPA	U1 small nuclear ribonucleoprotein A	2.428011789	2.185258813	1.547042958	0.82310152	2.306635301	1.185072239	2.306635301	1.185072239	1.94640902477507	0.232945	0	0.513766627297446	0.232409	0	GO:0005654,nucleoplasm;GO:0005681,spliceosomal complex;GO:0005685,U1 snRNP	GO:0042802,identical protein binding;GO:0003723,RNA binding;GO:0030619,U1 snRNA binding;GO:1990446,U1 snRNP binding	GO:0000398,mRNA splicing, via spliceosome;GO:1900363,regulation of mRNA polyadenylation	hsa:6626,path:hsa03040,Spliceosome
HDGR3_HUMAN	Q9Y3E1	HDGFL3	Hepatoma-derived growth factor-related protein 3	0.384012704	0.743048471	0.32948247	0.773940457	0.5635305875	0.5517114635	0.5635305875	0.5517114635	1.02142265437992	0.426334	0	0.979026650438917	0.426123	0	GO:0005829,cytosol;GO:0005576,extracellular region;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003690,double-stranded DNA binding;GO:0008083,growth factor activity;GO:0008017,microtubule binding;GO:0003712,transcription coregulator activity;GO:0015631,tubulin binding	GO:0046785,microtubule polymerization;GO:0007026,negative regulation of microtubule depolymerization;GO:0031175,neuron projection development;GO:0006357,regulation of transcription by RNA polymerase II	
FSCN1_HUMAN	Q16658	FSCN1	Fascin	3.751314752	10.23330689	5.364296048	7.121886525	6.992310821	6.2430912865	6.992310821	6.2430912865	1.12000778142074	0.396131	0	0.892850939599271	0.395856	0	GO:0015629,actin cytoskeleton;GO:0005938,cell cortex;GO:0031253,cell projection membrane;GO:0005911,cell-cell junction;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0030175,filopodium;GO:0030426,growth cone;GO:0030027,lamellipodium;GO:0044393,microspike;GO:0005902,microvillus;GO:0002102,podosome;GO:0001726,ruffle;GO:0001725,stress fiber	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0045296,cadherin binding;GO:0008144,drug binding;GO:0030674,protein-macromolecule adaptor activity;GO:0003723,RNA binding	GO:0030036,actin cytoskeleton organization;GO:0051017,actin filament bundle assembly;GO:0016477,cell migration;GO:0048870,cell motility;GO:0007043,cell-cell junction assembly;GO:0019221,cytokine-mediated signaling pathway;GO:0035089,establishment of apical/basal cell polarity;GO:0007163,establishment or maintenance of cell polarity;GO:0030035,microspike assembly;GO:0030046,parallel actin filament bundle assembly;GO:0090091,positive regulation of extracellular matrix disassembly;GO:0051491,positive regulation of filopodium assembly;GO:0010592,positive regulation of lamellipodium assembly;GO:0071803,positive regulation of podosome assembly;GO:0032956,regulation of actin cytoskeleton organization;GO:0032534,regulation of microvillus assembly;GO:0007015,actin filament organization	hsa:6624,path:hsa05206,MicroRNAs in cancer
RL14_HUMAN	P50914	RPL14	60S ribosomal protein L14	2.876789872	11.60606164	2.219588543	1.311332686	7.241425756	1.7654606145	7.241425756	1.7654606145	4.10172036494332	0.087316	0	0.243800140191619	0.086816	0	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0014069,postsynaptic density;GO:0005840,ribosome	GO:0045296,cadherin binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0042273,ribosomal large subunit biogenesis;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:9045,path:hsa03010,Ribosome
NUP85_HUMAN	Q9BW27	NUP85	Nuclear pore complex protein Nup85	0.114935543	0.087714089	0.72339648	0.192322953	0.101324816	0.4578597165	0.101324816	0.4578597165	0.221301006287589	0.022719	-1	4.51873227679979	0.022856	1	GO:0000777,condensed chromosome kinetochore;GO:0005829,cytosol;GO:0043657,host cell;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0031080,nuclear pore outer ring;GO:0005654,nucleoplasm;GO:0005819,spindle	GO:0017056,structural constituent of nuclear pore	GO:0075733,intracellular transport of virus;GO:0030032,lamellipodium assembly;GO:0048246,macrophage chemotaxis;GO:0007084,mitotic nuclear envelope reassembly;GO:0007052,mitotic spindle organization;GO:0006406,mRNA export from nucleus;GO:0072006,nephron development;GO:0045893,positive regulation of transcription, DNA-templated;GO:0006606,protein import into nucleus;GO:0016925,protein sumoylation;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription;GO:0051028,mRNA transport;GO:0015031,protein transport	hsa:79902,path:hsa03013,RNA transport
HS90A_HUMAN	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	92.46554021	171.9379233	126.8492783	111.6126451	132.201731755	119.2309617	132.201731755	119.2309617	1.10878692807692	0.399405	0	0.901886534443907	0.399136	0	GO:0044295,axonal growth cone;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0044294,dendritic growth cone;GO:0071682,endocytic vesicle lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0043202,lysosomal lumen;GO:0042470,melanosome;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0043209,myelin sheath;GO:0043025,neuronal cell body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0034774,secretory granule lumen	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0097718,disordered domain specific binding;GO:0070182,DNA polymerase binding;GO:0051020,GTPase binding;GO:0042826,histone deacetylase binding;GO:0042802,identical protein binding;GO:0023026,MHC class II protein complex binding;GO:0030235,nitric-oxide synthase regulator activity;GO:0044183,protein folding chaperone;GO:0042803,protein homodimerization activity;GO:1990782,protein tyrosine kinase binding;GO:0003723,RNA binding;GO:0097110,scaffold protein binding;GO:0048156,tau protein binding;GO:0030911,TPR domain binding;GO:0031625,ubiquitin protein ligase binding;GO:0051082,unfolded protein binding	GO:0002218,activation of innate immune response;GO:0048675,axon extension;GO:0034605,cellular response to heat;GO:0098586,cellular response to virus;GO:0021955,central nervous system neuron axonogenesis;GO:0061684,chaperone-mediated autophagy;GO:0051131,chaperone-mediated protein complex assembly;GO:0097711,ciliary basal body-plasma membrane docking;GO:0019221,cytokine-mediated signaling pathway;GO:0038128,ERBB2 signaling pathway;GO:0030010,establishment of cell polarity;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0000086,G2/M transition of mitotic cell cycle;GO:0006839,mitochondrial transport;GO:0043312,neutrophil degranulation;GO:1903364,positive regulation of cellular protein catabolic process;GO:0002230,positive regulation of defense response to virus by host;GO:0032728,positive regulation of interferon-beta production;GO:0045429,positive regulation of nitric oxide biosynthetic process;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0051897,positive regulation of protein kinase B signaling;GO:0001934,positive regulation of protein phosphorylation;GO:0032273,positive regulation of protein polymerization;GO:1902949,positive regulation of tau-protein kinase activity;GO:0051973,positive regulation of telomerase activity;GO:0006457,protein folding;GO:0045040,protein insertion into mitochondrial outer membrane;GO:0042026,protein refolding;GO:0050821,protein stabilization;GO:0043335,protein unfolding;GO:0006898,receptor-mediated endocytosis;GO:0042981,regulation of apoptotic process;GO:1903827,regulation of cellular protein localization;GO:1900034,regulation of cellular response to heat;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0060544,regulation of necroptotic process;GO:0050999,regulation of nitric-oxide synthase activity;GO:0031396,regulation of protein ubiquitination;GO:0043254,regulation of protein-containing complex assembly;GO:0046677,response to antibiotic;GO:0009409,response to cold;GO:0009408,response to heat;GO:0006986,response to unfolded protein;GO:1905323,telomerase holoenzyme complex assembly;GO:0007004,telomere maintenance via telomerase;GO:0046146,tetrahydrobiopterin metabolic process;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:0016032,viral process	hsa:3320,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:3320,path:hsa04151,PI3K-Akt signaling pathway;hsa:3320,path:hsa04217,Necroptosis;hsa:3320,path:hsa04621,NOD-like receptor signaling pathway;hsa:3320,path:hsa04612,Antigen processing and presentation;hsa:3320,path:hsa04659,Th17 cell differentiation;hsa:3320,path:hsa04657,IL-17 signaling pathway;hsa:3320,path:hsa04915,Estrogen signaling pathway;hsa:3320,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:3320,path:hsa05200,Pathways in cancer;hsa:3320,path:hsa05215,Prostate cancer;hsa:3320,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:3320,path:hsa05132,Salmonella infection
ALBU_HUMAN	P02768	ALB	Albumin	1343.759343	2281.917059	1658.118861	8403.874825	1812.838201	5030.996843	1812.838201	5030.996843	0.36033379816613	0.104638	0	2.77520456057512	0.104942	0	GO:0072562,blood microparticle;GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005794,Golgi apparatus;GO:0005634,nucleus;GO:0031093,platelet alpha granule lumen;GO:0032991,protein-containing complex	GO:0016209,antioxidant activity;GO:0051087,chaperone binding;GO:0005507,copper ion binding;GO:0003677,DNA binding;GO:1903981,enterobactin binding;GO:0140272,exogenous protein binding;GO:0005504,fatty acid binding;GO:0042802,identical protein binding;GO:0030170,pyridoxal phosphate binding;GO:0015643,toxic substance binding;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0044267,cellular protein metabolic process;GO:0009267,cellular response to starvation;GO:0006783,heme biosynthetic process;GO:0042167,heme catabolic process;GO:0034375,high-density lipoprotein particle remodeling;GO:0051659,maintenance of mitochondrion location;GO:0043066,negative regulation of apoptotic process;GO:0043069,negative regulation of programmed cell death;GO:0002576,platelet degranulation;GO:0043687,post-translational protein modification;GO:0006898,receptor-mediated endocytosis;GO:0001895,retina homeostasis	hsa:213,path:hsa04918,Thyroid hormone synthesis
TBB2A_HUMAN	Q13885	TUBB2A	Tubulin beta-2A chain	2.041011109	1.3751524	1.354675174	1.110288382	1.7080817545	1.232481778	1.7080817545	1.232481778	1.38588803906844	0.328916	0	0.721559008960188	0.328513	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:1903561,extracellular vesicle;GO:0005874,microtubule;GO:0005634,nucleus	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0005200,structural constituent of cytoskeleton	GO:0000226,microtubule cytoskeleton organization;GO:0000278,mitotic cell cycle;GO:0001764,neuron migration	hsa:7280,path:hsa04145,Phagosome;hsa:7280,path:hsa04540,Gap junction;hsa:7280,path:hsa05130,Pathogenic Escherichia coli infection
UBXN4_HUMAN	Q92575	UBXN4	UBX domain-containing protein 4	0.1622136	0.135793377	0.447191017	0.116211423	0.1490034885	0.28170122	0.1490034885	0.28170122	0.528941580373702	0.251762	0	1.89056795136713	0.252080	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005635,nuclear envelope		GO:0006986,response to unfolded protein;GO:0030433,ubiquitin-dependent ERAD pathway	
RS21_HUMAN	P63220	RPS21	40S ribosomal protein S21	1.658334485	1.564318487	1.296013964	1.902528339	1.611326486	1.5992711515	1.611326486	1.5992711515	1.00753801785813	0.430863	0	0.992518378736561	0.430660	0	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0005654,nucleoplasm;GO:0042788,polysomal ribosome;GO:0005791,rough endoplasmic reticulum;GO:0015935,small ribosomal subunit;GO:0005840,ribosome;GO:0045202,synapse	GO:0047485,protein N-terminus binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000447,endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000461,endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6227,path:hsa03010,Ribosome
VINC_HUMAN	P18206	VCL	Vinculin	46.7406916	45.34485859	37.53797412	116.8578535	46.042775095	77.19791381	46.042775095	77.19791381	0.596425121128542	0.313677	0	1.67665640593378	0.313956	0	GO:0005912,adherens junction;GO:0005903,brush border;GO:0044291,cell-cell contact zone;GO:0005911,cell-cell junction;GO:0030055,cell-substrate junction;GO:0043034,costamere;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1903561,extracellular vesicle;GO:0005916,fascia adherens;GO:1904813,ficolin-1-rich granule lumen;GO:0005925,focal adhesion;GO:0090637,inner dense plaque of desmosome;GO:0045121,membrane raft;GO:0090636,outer dense plaque of desmosome;GO:0005886,plasma membrane;GO:0002102,podosome;GO:0032991,protein-containing complex;GO:0042383,sarcolemma;GO:0034774,secretory granule lumen;GO:0035580,specific granule lumen;GO:1990357,terminal web;GO:0005915,zonula adherens;GO:0005737,cytoplasm	GO:0003779,actin binding;GO:0045294,alpha-catenin binding;GO:0008013,beta-catenin binding;GO:0045296,cadherin binding;GO:0002162,dystroglycan binding;GO:0005198,structural molecule activity;GO:0031625,ubiquitin protein ligase binding;GO:0051015,actin filament binding	GO:0034333,adherens junction assembly;GO:0043297,apical junction assembly;GO:0048675,axon extension;GO:0007155,cell adhesion;GO:0007160,cell-matrix adhesion;GO:0090136,epithelial cell-cell adhesion;GO:0030032,lamellipodium assembly;GO:0035633,maintenance of blood-brain barrier;GO:0002009,morphogenesis of an epithelium;GO:0006936,muscle contraction;GO:0030336,negative regulation of cell migration;GO:0043312,neutrophil degranulation;GO:0070527,platelet aggregation;GO:0002576,platelet degranulation;GO:0034394,protein localization to cell surface;GO:1903140,regulation of establishment of endothelial barrier;GO:0051893,regulation of focal adhesion assembly;GO:1904702,regulation of protein localization to adherens junction	hsa:7414,path:hsa04510,Focal adhesion;hsa:7414,path:hsa04520,Adherens junction;hsa:7414,path:hsa04810,Regulation of actin cytoskeleton;hsa:7414,path:hsa04670,Leukocyte transendothelial migration;hsa:7414,path:hsa05131,Shigellosis;hsa:7414,path:hsa05100,Bacterial invasion of epithelial cells;hsa:7414,path:hsa05146,Amoebiasis
EFR3A_HUMAN	Q14156	EFR3A	Protein EFR3 homolog A	0.028261758	0.202437257	0.162302141	0.287787614	0.1153495075	0.2250448775	0.1153495075	0.2250448775	0.512562244390566	0.236679	0	1.95098256054539	0.237003	0	GO:0005829,cytosol;GO:0005886,plasma membrane		GO:0046854,phosphatidylinositol phosphorylation;GO:0072659,protein localization to plasma membrane	
DDB1_HUMAN	Q16531	DDB1	DNA damage-binding protein 1	12.37789838	10.44221873	14.98056639	14.68217081	11.410058555	14.8313686	11.410058555	14.8313686	0.769319330044835	0.461584	0	1.29985034945336	0.461719	0	GO:0000781,chromosome, telomeric region;GO:0080008,Cul4-RING E3 ubiquitin ligase complex;GO:0031464,Cul4A-RING E3 ubiquitin ligase complex;GO:0031465,Cul4B-RING E3 ubiquitin ligase complex;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0035861,site of double-strand break	GO:0097602,cullin family protein binding;GO:0003684,damaged DNA binding;GO:0003677,DNA binding;GO:0044877,protein-containing complex binding;GO:0030674,protein-macromolecule adaptor activity;GO:0071987,WD40-repeat domain binding;GO:0003676,nucleic acid binding	GO:0051702,biological process involved in interaction with symbiont;GO:0006974,cellular response to DNA damage stimulus;GO:0042769,DNA damage response, detection of DNA damage;GO:0006281,DNA repair;GO:0070911,global genome nucleotide-excision repair;GO:0035518,histone H2A monoubiquitination;GO:0006289,nucleotide-excision repair;GO:0000715,nucleotide-excision repair, DNA damage recognition;GO:0000717,nucleotide-excision repair, DNA duplex unwinding;GO:0033683,nucleotide-excision repair, DNA incision;GO:0006295,nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006294,nucleotide-excision repair, preincision complex assembly;GO:0006293,nucleotide-excision repair, preincision complex stabilization;GO:0046726,positive regulation by virus of viral protein levels in host cell;GO:0045722,positive regulation of gluconeogenesis;GO:0045732,positive regulation of protein catabolic process;GO:0045070,positive regulation of viral genome replication;GO:1902188,positive regulation of viral release from host cell;GO:0043687,post-translational protein modification;GO:0010498,proteasomal protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567,protein ubiquitination;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0048511,rhythmic process;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0070914,UV-damage excision repair;GO:0016032,viral process	hsa:1642,path:hsa04120,Ubiquitin mediated proteolysis;hsa:1642,path:hsa03420,Nucleotide excision repair;hsa:1642,path:hsa05203,Viral carcinogenesis;hsa:1642,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:1642,path:hsa05161,Hepatitis B
SIAS_HUMAN	Q9NR45	NANS	Sialic acid synthase	2.983782573	1.327251202	4.110370759	2.438906401	2.1555168875	3.27463858	2.1555168875	3.27463858	0.658245737610531	0.368913	0	1.51918948025407	0.369144	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0050462,N-acetylneuraminate synthase activity;GO:0008781,N-acylneuraminate cytidylyltransferase activity;GO:0047444,N-acylneuraminate-9-phosphate synthase activity;GO:0003824,catalytic activity	GO:0016051,carbohydrate biosynthetic process;GO:0006055,CMP-N-acetylneuraminate biosynthetic process;GO:0070085,glycosylation	hsa:54187,path:hsa00520,Amino sugar and nucleotide sugar metabolism
DPA1_HUMAN	P20036	HLA-DPA1	HLA class II histocompatibility antigen, DP alpha 1 chain	0.449717326	0.69543867	0.3910853	0.483961203	0.572577998	0.4375232515	0.572577998	0.4375232515	1.30868015822469	0.346571	0	0.76412864802395	0.346199	0	GO:0009986,cell surface;GO:0031901,early endosome membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0000139,Golgi membrane;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0042612,MHC class I protein complex;GO:0032398,MHC class Ib protein complex;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0030667,secretory granule membrane;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0030666,endocytic vesicle membrane;GO:0001772,immunological synapse;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0042613,MHC class II protein complex;GO:0032588,trans-Golgi network membrane;GO:0030658,transport vesicle membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0010008,endosome membrane;GO:0005882,intermediate filament;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0005797,Golgi medial cisterna;GO:0042824,MHC class I peptide loading complex;GO:0035577,azurophil granule membrane;GO:0033106,cis-Golgi network membrane;GO:0005769,early endosome;GO:0031527,filopodium membrane;GO:0005771,multivesicular body	GO:0030881,beta-2-microglobulin binding;GO:0042288,MHC class I protein binding;GO:0046703,natural killer cell lectin-like receptor binding;GO:0042605,peptide antigen binding;GO:0005102,signaling receptor binding;GO:0042608,T cell receptor binding;GO:0051087,chaperone binding;GO:0046977,TAP binding;GO:0023026,MHC class II protein complex binding;GO:0032395,MHC class II receptor activity;GO:0030247,polysaccharide binding;GO:0042609,CD4 receptor binding;GO:0005200,structural constituent of cytoskeleton;GO:0042610,CD8 receptor binding;GO:0003723,RNA binding;GO:0062061,TAP complex binding;GO:0071889,14-3-3 protein binding;GO:0046978,TAP1 binding;GO:0046979,TAP2 binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:1990405,protein antigen binding;GO:0015643,toxic substance binding;GO:0008134,transcription factor binding;GO:0031625,ubiquitin protein ligase binding;GO:0046872,metal ion binding	GO:0002250,adaptive immune response;GO:0019731,antibacterial humoral response;GO:0002476,antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0002477,antigen processing and presentation of exogenous peptide antigen via MHC class Ib;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0036037,CD8-positive, alpha-beta T cell activation;GO:0050830,defense response to Gram-positive bacterium;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0002519,natural killer cell tolerance induction;GO:0045953,negative regulation of natural killer cell mediated cytotoxicity;GO:0001815,positive regulation of antibody-dependent cellular cytotoxicity;GO:2001187,positive regulation of CD8-positive, alpha-beta T cell activation;GO:2000566,positive regulation of CD8-positive, alpha-beta T cell proliferation;GO:0002639,positive regulation of immunoglobulin production;GO:0032736,positive regulation of interleukin-13 production;GO:0032753,positive regulation of interleukin-4 production;GO:0002729,positive regulation of natural killer cell cytokine production;GO:0045954,positive regulation of natural killer cell mediated cytotoxicity;GO:0002717,positive regulation of natural killer cell mediated immunity;GO:0032819,positive regulation of natural killer cell proliferation;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:0032759,positive regulation of TRAIL production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0042270,protection from natural killer cell mediated cytotoxicity;GO:0050776,regulation of immune response;GO:0002715,regulation of natural killer cell mediated immunity;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process;GO:0002486,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006952,defense response;GO:0016045,detection of bacterium;GO:0006955,immune response;GO:0043312,neutrophil degranulation;GO:2001198,regulation of dendritic cell differentiation;GO:0032655,regulation of interleukin-12 production;GO:0032675,regulation of interleukin-6 production;GO:0002667,regulation of T cell anergy;GO:0002491,antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002504,antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0050890,cognition;GO:0002469,myeloid dendritic cell antigen processing and presentation;GO:0002503,peptide antigen assembly with MHC class II protein complex;GO:2000516,positive regulation of CD4-positive, alpha-beta T cell activation;GO:0032831,positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0043382,positive regulation of memory T cell differentiation;GO:0045622,regulation of T-helper cell differentiation;GO:0050852,T cell receptor signaling pathway;GO:0002399,MHC class II protein complex assembly;GO:2001190,positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0042102,positive regulation of T cell proliferation;GO:0032729,positive regulation of interferon-gamma production;GO:0050870,positive regulation of T cell activation;GO:0008544,epidermis development;GO:0006959,humoral immune response;GO:0002437,inflammatory response to antigenic stimulus;GO:0030225,macrophage differentiation;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0032689,negative regulation of interferon-gamma production;GO:0042130,negative regulation of T cell proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0033674,positive regulation of kinase activity;GO:0043410,positive regulation of MAPK cascade;GO:0045657,positive regulation of monocyte differentiation;GO:0001934,positive regulation of protein phosphorylation;GO:0002842,positive regulation of T cell mediated immune response to tumor cell;GO:0045893,positive regulation of transcription, DNA-templated;GO:0046598,positive regulation of viral entry into host cell;GO:0051262,protein tetramerization;GO:0032653,regulation of interleukin-10 production;GO:0032673,regulation of interleukin-4 production;GO:0007165,signal transduction;GO:0042088,T-helper 1 type immune response;GO:0002587,negative regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0045580,regulation of T cell differentiation;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002485,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent;GO:0042590,antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:2000568,positive regulation of memory T cell activation;GO:0002726,positive regulation of T cell cytokine production;GO:0016567,protein ubiquitination;GO:0001913,T cell mediated cytotoxicity;GO:0002419,T cell mediated cytotoxicity directed against tumor cell target;GO:0002728,negative regulation of natural killer cell cytokine production;GO:0043322,negative regulation of natural killer cell degranulation;GO:1901215,negative regulation of neuron death;GO:0002725,negative regulation of T cell cytokine production;GO:0043323,positive regulation of natural killer cell degranulation;GO:0071346,cellular response to interferon-gamma;GO:0006968,cellular defense response;GO:0002767,immune response-inhibiting cell surface receptor signaling pathway;GO:0016525,negative regulation of angiogenesis;GO:2001199,negative regulation of dendritic cell differentiation;GO:0070317,negative regulation of G0 to G1 transition;GO:0050777,negative regulation of immune response;GO:0051898,negative regulation of protein kinase B signaling;GO:0001915,negative regulation of T cell mediated cytotoxicity;GO:0002451,peripheral B cell tolerance induction;GO:2000774,positive regulation of cellular senescence;GO:2000353,positive regulation of endothelial cell apoptotic process;GO:0032735,positive regulation of interleukin-12 production;GO:0060907,positive regulation of macrophage cytokine production;GO:0045591,positive regulation of regulatory T cell differentiation;GO:0002666,positive regulation of T cell tolerance induction;GO:0002645,positive regulation of tolerance induction;GO:0070207,protein homotrimerization;GO:0019882,antigen processing and presentation;GO:0002344,B cell affinity maturation;GO:0046635,positive regulation of alpha-beta T cell activation;GO:0002579,positive regulation of antigen processing and presentation;GO:0002827,positive regulation of T-helper 1 type immune response	hsa:3133,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3133,path:hsa04144,Endocytosis;hsa:3133,path:hsa04145,Phagosome;hsa:3133,path:hsa04218,Cellular senescence;hsa:3133,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3133,path:hsa04612,Antigen processing and presentation;hsa:3133,path:hsa05203,Viral carcinogenesis;hsa:3133,path:hsa05320,Autoimmune thyroid disease;hsa:3133,path:hsa05330,Allograft rejection;hsa:3133,path:hsa05332,Graft-versus-host disease;hsa:3133,path:hsa05416,Viral myocarditis;hsa:3133,path:hsa04940,Type I diabetes mellitus;hsa:3133,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3133,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3133,path:hsa05168,Herpes simplex virus 1 infection;hsa:3133,path:hsa05163,Human cytomegalovirus infection;hsa:3133,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3133,path:hsa05169,Epstein-Barr virus infection;hsa:3133,path:hsa05165,Human papillomavirus infection;hsa:3106,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3106,path:hsa04144,Endocytosis;hsa:3106,path:hsa04145,Phagosome;hsa:3106,path:hsa04218,Cellular senescence;hsa:3106,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3106,path:hsa04612,Antigen processing and presentation;hsa:3106,path:hsa05203,Viral carcinogenesis;hsa:3106,path:hsa05320,Autoimmune thyroid disease;hsa:3106,path:hsa05330,Allograft rejection;hsa:3106,path:hsa05332,Graft-versus-host disease;hsa:3106,path:hsa05416,Viral myocarditis;hsa:3106,path:hsa04940,Type I diabetes mellitus;hsa:3106,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3106,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3106,path:hsa05168,Herpes simplex virus 1 infection;hsa:3106,path:hsa05163,Human cytomegalovirus infection;hsa:3106,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3106,path:hsa05169,Epstein-Barr virus infection;hsa:3106,path:hsa05165,Human papillomavirus infection;hsa:3122,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3122,path:hsa04145,Phagosome;hsa:3122,path:hsa04640,Hematopoietic cell lineage;hsa:3122,path:hsa04612,Antigen processing and presentation;hsa:3122,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3122,path:hsa04659,Th17 cell differentiation;hsa:3122,path:hsa04672,Intestinal immune network for IgA production;hsa:3122,path:hsa05310,Asthma;hsa:3122,path:hsa05322,Systemic lupus erythematosus;hsa:3122,path:hsa05323,Rheumatoid arthritis;hsa:3122,path:hsa05320,Autoimmune thyroid disease;hsa:3122,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3122,path:hsa05330,Allograft rejection;hsa:3122,path:hsa05332,Graft-versus-host disease;hsa:3122,path:hsa05416,Viral myocarditis;hsa:3122,path:hsa04940,Type I diabetes mellitus;hsa:3122,path:hsa05150,Staphylococcus aureus infection;hsa:3122,path:hsa05152,Tuberculosis;hsa:3122,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3122,path:hsa05164,Influenza A;hsa:3122,path:hsa05168,Herpes simplex virus 1 infection;hsa:3122,path:hsa05169,Epstein-Barr virus infection;hsa:3122,path:hsa05145,Toxoplasmosis;hsa:3122,path:hsa05140,Leishmaniasis;hsa:3109,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3109,path:hsa04145,Phagosome;hsa:3109,path:hsa04640,Hematopoietic cell lineage;hsa:3109,path:hsa04612,Antigen processing and presentation;hsa:3109,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3109,path:hsa04659,Th17 cell differentiation;hsa:3109,path:hsa04672,Intestinal immune network for IgA production;hsa:3109,path:hsa05310,Asthma;hsa:3109,path:hsa05322,Systemic lupus erythematosus;hsa:3109,path:hsa05323,Rheumatoid arthritis;hsa:3109,path:hsa05320,Autoimmune thyroid disease;hsa:3109,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3109,path:hsa05330,Allograft rejection;hsa:3109,path:hsa05332,Graft-versus-host disease;hsa:3109,path:hsa05416,Viral myocarditis;hsa:3109,path:hsa04940,Type I diabetes mellitus;hsa:3109,path:hsa05150,Staphylococcus aureus infection;hsa:3109,path:hsa05152,Tuberculosis;hsa:3109,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3109,path:hsa05164,Influenza A;hsa:3109,path:hsa05168,Herpes simplex virus 1 infection;hsa:3109,path:hsa05169,Epstein-Barr virus infection;hsa:3109,path:hsa05145,Toxoplasmosis;hsa:3109,path:hsa05140,Leishmaniasis;hsa:3115,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3115,path:hsa04145,Phagosome;hsa:3115,path:hsa04640,Hematopoietic cell lineage;hsa:3115,path:hsa04612,Antigen processing and presentation;hsa:3115,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3115,path:hsa04659,Th17 cell differentiation;hsa:3115,path:hsa04672,Intestinal immune network for IgA production;hsa:3115,path:hsa05310,Asthma;hsa:3115,path:hsa05322,Systemic lupus erythematosus;hsa:3115,path:hsa05323,Rheumatoid arthritis;hsa:3115,path:hsa05320,Autoimmune thyroid disease;hsa:3115,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3115,path:hsa05330,Allograft rejection;hsa:3115,path:hsa05332,Graft-versus-host disease;hsa:3115,path:hsa05416,Viral myocarditis;hsa:3115,path:hsa04940,Type I diabetes mellitus;hsa:3115,path:hsa05150,Staphylococcus aureus infection;hsa:3115,path:hsa05152,Tuberculosis;hsa:3115,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3115,path:hsa05164,Influenza A;hsa:3115,path:hsa05168,Herpes simplex virus 1 infection;hsa:3115,path:hsa05169,Epstein-Barr virus infection;hsa:3115,path:hsa05145,Toxoplasmosis;hsa:3115,path:hsa05140,Leishmaniasis;hsa:3123,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3123,path:hsa04145,Phagosome;hsa:3123,path:hsa04640,Hematopoietic cell lineage;hsa:3123,path:hsa04612,Antigen processing and presentation;hsa:3123,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3123,path:hsa04659,Th17 cell differentiation;hsa:3123,path:hsa04672,Intestinal immune network for IgA production;hsa:3123,path:hsa05310,Asthma;hsa:3123,path:hsa05322,Systemic lupus erythematosus;hsa:3123,path:hsa05323,Rheumatoid arthritis;hsa:3123,path:hsa05320,Autoimmune thyroid disease;hsa:3123,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3123,path:hsa05330,Allograft rejection;hsa:3123,path:hsa05332,Graft-versus-host disease;hsa:3123,path:hsa05416,Viral myocarditis;hsa:3123,path:hsa04940,Type I diabetes mellitus;hsa:3123,path:hsa05150,Staphylococcus aureus infection;hsa:3123,path:hsa05152,Tuberculosis;hsa:3123,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3123,path:hsa05164,Influenza A;hsa:3123,path:hsa05168,Herpes simplex virus 1 infection;hsa:3123,path:hsa05169,Epstein-Barr virus infection;hsa:3123,path:hsa05145,Toxoplasmosis;hsa:3123,path:hsa05140,Leishmaniasis;hsa:3111,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3111,path:hsa04145,Phagosome;hsa:3111,path:hsa04640,Hematopoietic cell lineage;hsa:3111,path:hsa04612,Antigen processing and presentation;hsa:3111,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3111,path:hsa04659,Th17 cell differentiation;hsa:3111,path:hsa04672,Intestinal immune network for IgA production;hsa:3111,path:hsa05310,Asthma;hsa:3111,path:hsa05322,Systemic lupus erythematosus;hsa:3111,path:hsa05323,Rheumatoid arthritis;hsa:3111,path:hsa05320,Autoimmune thyroid disease;hsa:3111,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3111,path:hsa05330,Allograft rejection;hsa:3111,path:hsa05332,Graft-versus-host disease;hsa:3111,path:hsa05416,Viral myocarditis;hsa:3111,path:hsa04940,Type I diabetes mellitus;hsa:3111,path:hsa05150,Staphylococcus aureus infection;hsa:3111,path:hsa05152,Tuberculosis;hsa:3111,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3111,path:hsa05164,Influenza A;hsa:3111,path:hsa05168,Herpes simplex virus 1 infection;hsa:3111,path:hsa05169,Epstein-Barr virus infection;hsa:3111,path:hsa05145,Toxoplasmosis;hsa:3111,path:hsa05140,Leishmaniasis;hsa:3112,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3112,path:hsa04145,Phagosome;hsa:3112,path:hsa04640,Hematopoietic cell lineage;hsa:3112,path:hsa04612,Antigen processing and presentation;hsa:3112,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3112,path:hsa04659,Th17 cell differentiation;hsa:3112,path:hsa04672,Intestinal immune network for IgA production;hsa:3112,path:hsa05310,Asthma;hsa:3112,path:hsa05322,Systemic lupus erythematosus;hsa:3112,path:hsa05323,Rheumatoid arthritis;hsa:3112,path:hsa05320,Autoimmune thyroid disease;hsa:3112,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3112,path:hsa05330,Allograft rejection;hsa:3112,path:hsa05332,Graft-versus-host disease;hsa:3112,path:hsa05416,Viral myocarditis;hsa:3112,path:hsa04940,Type I diabetes mellitus;hsa:3112,path:hsa05150,Staphylococcus aureus infection;hsa:3112,path:hsa05152,Tuberculosis;hsa:3112,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3112,path:hsa05164,Influenza A;hsa:3112,path:hsa05168,Herpes simplex virus 1 infection;hsa:3112,path:hsa05169,Epstein-Barr virus infection;hsa:3112,path:hsa05145,Toxoplasmosis;hsa:3112,path:hsa05140,Leishmaniasis;hsa:3105,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3105,path:hsa04144,Endocytosis;hsa:3105,path:hsa04145,Phagosome;hsa:3105,path:hsa04218,Cellular senescence;hsa:3105,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3105,path:hsa04612,Antigen processing and presentation;hsa:3105,path:hsa05203,Viral carcinogenesis;hsa:3105,path:hsa05320,Autoimmune thyroid disease;hsa:3105,path:hsa05330,Allograft rejection;hsa:3105,path:hsa05332,Graft-versus-host disease;hsa:3105,path:hsa05416,Viral myocarditis;hsa:3105,path:hsa04940,Type I diabetes mellitus;hsa:3105,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3105,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3105,path:hsa05168,Herpes simplex virus 1 infection;hsa:3105,path:hsa05163,Human cytomegalovirus infection;hsa:3105,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3105,path:hsa05169,Epstein-Barr virus infection;hsa:3105,path:hsa05165,Human papillomavirus infection;hsa:3134,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3134,path:hsa04144,Endocytosis;hsa:3134,path:hsa04145,Phagosome;hsa:3134,path:hsa04218,Cellular senescence;hsa:3134,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3134,path:hsa04612,Antigen processing and presentation;hsa:3134,path:hsa05203,Viral carcinogenesis;hsa:3134,path:hsa05320,Autoimmune thyroid disease;hsa:3134,path:hsa05330,Allograft rejection;hsa:3134,path:hsa05332,Graft-versus-host disease;hsa:3134,path:hsa05416,Viral myocarditis;hsa:3134,path:hsa04940,Type I diabetes mellitus;hsa:3134,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3134,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3134,path:hsa05168,Herpes simplex virus 1 infection;hsa:3134,path:hsa05163,Human cytomegalovirus infection;hsa:3134,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3134,path:hsa05169,Epstein-Barr virus infection;hsa:3134,path:hsa05165,Human papillomavirus infection;hsa:3119,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3119,path:hsa04145,Phagosome;hsa:3119,path:hsa04640,Hematopoietic cell lineage;hsa:3119,path:hsa04612,Antigen processing and presentation;hsa:3119,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3119,path:hsa04659,Th17 cell differentiation;hsa:3119,path:hsa04672,Intestinal immune network for IgA production;hsa:3119,path:hsa05310,Asthma;hsa:3119,path:hsa05322,Systemic lupus erythematosus;hsa:3119,path:hsa05323,Rheumatoid arthritis;hsa:3119,path:hsa05320,Autoimmune thyroid disease;hsa:3119,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3119,path:hsa05330,Allograft rejection;hsa:3119,path:hsa05332,Graft-versus-host disease;hsa:3119,path:hsa05416,Viral myocarditis;hsa:3119,path:hsa04940,Type I diabetes mellitus;hsa:3119,path:hsa05150,Staphylococcus aureus infection;hsa:3119,path:hsa05152,Tuberculosis;hsa:3119,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3119,path:hsa05164,Influenza A;hsa:3119,path:hsa05168,Herpes simplex virus 1 infection;hsa:3119,path:hsa05169,Epstein-Barr virus infection;hsa:3119,path:hsa05145,Toxoplasmosis;hsa:3119,path:hsa05140,Leishmaniasis;hsa:3113,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3113,path:hsa04145,Phagosome;hsa:3113,path:hsa04640,Hematopoietic cell lineage;hsa:3113,path:hsa04612,Antigen processing and presentation;hsa:3113,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3113,path:hsa04659,Th17 cell differentiation;hsa:3113,path:hsa04672,Intestinal immune network for IgA production;hsa:3113,path:hsa05310,Asthma;hsa:3113,path:hsa05322,Systemic lupus erythematosus;hsa:3113,path:hsa05323,Rheumatoid arthritis;hsa:3113,path:hsa05320,Autoimmune thyroid disease;hsa:3113,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3113,path:hsa05330,Allograft rejection;hsa:3113,path:hsa05332,Graft-versus-host disease;hsa:3113,path:hsa05416,Viral myocarditis;hsa:3113,path:hsa04940,Type I diabetes mellitus;hsa:3113,path:hsa05150,Staphylococcus aureus infection;hsa:3113,path:hsa05152,Tuberculosis;hsa:3113,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3113,path:hsa05164,Influenza A;hsa:3113,path:hsa05168,Herpes simplex virus 1 infection;hsa:3113,path:hsa05169,Epstein-Barr virus infection;hsa:3113,path:hsa05145,Toxoplasmosis;hsa:3113,path:hsa05140,Leishmaniasis;hsa:3125,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3125,path:hsa04145,Phagosome;hsa:3125,path:hsa04640,Hematopoietic cell lineage;hsa:3125,path:hsa04612,Antigen processing and presentation;hsa:3125,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3125,path:hsa04659,Th17 cell differentiation;hsa:3125,path:hsa04672,Intestinal immune network for IgA production;hsa:3125,path:hsa05310,Asthma;hsa:3125,path:hsa05322,Systemic lupus erythematosus;hsa:3125,path:hsa05323,Rheumatoid arthritis;hsa:3125,path:hsa05320,Autoimmune thyroid disease;hsa:3125,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3125,path:hsa05330,Allograft rejection;hsa:3125,path:hsa05332,Graft-versus-host disease;hsa:3125,path:hsa05416,Viral myocarditis;hsa:3125,path:hsa04940,Type I diabetes mellitus;hsa:3125,path:hsa05150,Staphylococcus aureus infection;hsa:3125,path:hsa05152,Tuberculosis;hsa:3125,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3125,path:hsa05164,Influenza A;hsa:3125,path:hsa05168,Herpes simplex virus 1 infection;hsa:3125,path:hsa05169,Epstein-Barr virus infection;hsa:3125,path:hsa05145,Toxoplasmosis;hsa:3125,path:hsa05140,Leishmaniasis;hsa:3126,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3126,path:hsa04145,Phagosome;hsa:3126,path:hsa04640,Hematopoietic cell lineage;hsa:3126,path:hsa04612,Antigen processing and presentation;hsa:3126,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3126,path:hsa04659,Th17 cell differentiation;hsa:3126,path:hsa04672,Intestinal immune network for IgA production;hsa:3126,path:hsa05310,Asthma;hsa:3126,path:hsa05322,Systemic lupus erythematosus;hsa:3126,path:hsa05323,Rheumatoid arthritis;hsa:3126,path:hsa05320,Autoimmune thyroid disease;hsa:3126,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3126,path:hsa05330,Allograft rejection;hsa:3126,path:hsa05332,Graft-versus-host disease;hsa:3126,path:hsa05416,Viral myocarditis;hsa:3126,path:hsa04940,Type I diabetes mellitus;hsa:3126,path:hsa05150,Staphylococcus aureus infection;hsa:3126,path:hsa05152,Tuberculosis;hsa:3126,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3126,path:hsa05164,Influenza A;hsa:3126,path:hsa05168,Herpes simplex virus 1 infection;hsa:3126,path:hsa05169,Epstein-Barr virus infection;hsa:3126,path:hsa05145,Toxoplasmosis;hsa:3126,path:hsa05140,Leishmaniasis;hsa:3107,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3107,path:hsa04144,Endocytosis;hsa:3107,path:hsa04145,Phagosome;hsa:3107,path:hsa04218,Cellular senescence;hsa:3107,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3107,path:hsa04612,Antigen processing and presentation;hsa:3107,path:hsa05203,Viral carcinogenesis;hsa:3107,path:hsa05320,Autoimmune thyroid disease;hsa:3107,path:hsa05330,Allograft rejection;hsa:3107,path:hsa05332,Graft-versus-host disease;hsa:3107,path:hsa05416,Viral myocarditis;hsa:3107,path:hsa04940,Type I diabetes mellitus;hsa:3107,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3107,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3107,path:hsa05168,Herpes simplex virus 1 infection;hsa:3107,path:hsa05163,Human cytomegalovirus infection;hsa:3107,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3107,path:hsa05169,Epstein-Barr virus infection;hsa:3107,path:hsa05165,Human papillomavirus infection;hsa:3135,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3135,path:hsa04144,Endocytosis;hsa:3135,path:hsa04145,Phagosome;hsa:3135,path:hsa04218,Cellular senescence;hsa:3135,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3135,path:hsa04612,Antigen processing and presentation;hsa:3135,path:hsa05203,Viral carcinogenesis;hsa:3135,path:hsa05320,Autoimmune thyroid disease;hsa:3135,path:hsa05330,Allograft rejection;hsa:3135,path:hsa05332,Graft-versus-host disease;hsa:3135,path:hsa05416,Viral myocarditis;hsa:3135,path:hsa04940,Type I diabetes mellitus;hsa:3135,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3135,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3135,path:hsa05168,Herpes simplex virus 1 infection;hsa:3135,path:hsa05163,Human cytomegalovirus infection;hsa:3135,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3135,path:hsa05169,Epstein-Barr virus infection;hsa:3135,path:hsa05165,Human papillomavirus infection;hsa:3127,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3127,path:hsa04145,Phagosome;hsa:3127,path:hsa04640,Hematopoietic cell lineage;hsa:3127,path:hsa04612,Antigen processing and presentation;hsa:3127,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3127,path:hsa04659,Th17 cell differentiation;hsa:3127,path:hsa04672,Intestinal immune network for IgA production;hsa:3127,path:hsa05310,Asthma;hsa:3127,path:hsa05322,Systemic lupus erythematosus;hsa:3127,path:hsa05323,Rheumatoid arthritis;hsa:3127,path:hsa05320,Autoimmune thyroid disease;hsa:3127,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3127,path:hsa05330,Allograft rejection;hsa:3127,path:hsa05332,Graft-versus-host disease;hsa:3127,path:hsa05416,Viral myocarditis;hsa:3127,path:hsa04940,Type I diabetes mellitus;hsa:3127,path:hsa05150,Staphylococcus aureus infection;hsa:3127,path:hsa05152,Tuberculosis;hsa:3127,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3127,path:hsa05164,Influenza A;hsa:3127,path:hsa05168,Herpes simplex virus 1 infection;hsa:3127,path:hsa05169,Epstein-Barr virus infection;hsa:3127,path:hsa05145,Toxoplasmosis;hsa:3127,path:hsa05140,Leishmaniasis;hsa:3118,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3118,path:hsa04145,Phagosome;hsa:3118,path:hsa04640,Hematopoietic cell lineage;hsa:3118,path:hsa04612,Antigen processing and presentation;hsa:3118,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3118,path:hsa04659,Th17 cell differentiation;hsa:3118,path:hsa04672,Intestinal immune network for IgA production;hsa:3118,path:hsa05310,Asthma;hsa:3118,path:hsa05322,Systemic lupus erythematosus;hsa:3118,path:hsa05323,Rheumatoid arthritis;hsa:3118,path:hsa05320,Autoimmune thyroid disease;hsa:3118,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3118,path:hsa05330,Allograft rejection;hsa:3118,path:hsa05332,Graft-versus-host disease;hsa:3118,path:hsa05416,Viral myocarditis;hsa:3118,path:hsa04940,Type I diabetes mellitus;hsa:3118,path:hsa05150,Staphylococcus aureus infection;hsa:3118,path:hsa05152,Tuberculosis;hsa:3118,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3118,path:hsa05164,Influenza A;hsa:3118,path:hsa05168,Herpes simplex virus 1 infection;hsa:3118,path:hsa05169,Epstein-Barr virus infection;hsa:3118,path:hsa05145,Toxoplasmosis;hsa:3118,path:hsa05140,Leishmaniasis;hsa:3117,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3117,path:hsa04145,Phagosome;hsa:3117,path:hsa04640,Hematopoietic cell lineage;hsa:3117,path:hsa04612,Antigen processing and presentation;hsa:3117,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3117,path:hsa04659,Th17 cell differentiation;hsa:3117,path:hsa04672,Intestinal immune network for IgA production;hsa:3117,path:hsa05310,Asthma;hsa:3117,path:hsa05322,Systemic lupus erythematosus;hsa:3117,path:hsa05323,Rheumatoid arthritis;hsa:3117,path:hsa05320,Autoimmune thyroid disease;hsa:3117,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3117,path:hsa05330,Allograft rejection;hsa:3117,path:hsa05332,Graft-versus-host disease;hsa:3117,path:hsa05416,Viral myocarditis;hsa:3117,path:hsa04940,Type I diabetes mellitus;hsa:3117,path:hsa05150,Staphylococcus aureus infection;hsa:3117,path:hsa05152,Tuberculosis;hsa:3117,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3117,path:hsa05164,Influenza A;hsa:3117,path:hsa05168,Herpes simplex virus 1 infection;hsa:3117,path:hsa05169,Epstein-Barr virus infection;hsa:3117,path:hsa05145,Toxoplasmosis;hsa:3117,path:hsa05140,Leishmaniasis
UD19_HUMAN	O60656	UGT1A9	UDP-glucuronosyltransferase 1A9	2.55E-05	2.55E-05	2.55E-05	2.55E-05	2.55e-005	2.55e-005	2.55e-005	2.55e-005	1	0.433351	0	1	0.433154	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane	GO:0019899,enzyme binding;GO:0004857,enzyme inhibitor activity;GO:0015020,glucuronosyltransferase activity;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0001972,retinoic acid binding	GO:0052695,cellular glucuronidation;GO:0051552,flavone metabolic process;GO:0052696,flavonoid glucuronidation;GO:2001030,negative regulation of cellular glucuronidation;GO:0045922,negative regulation of fatty acid metabolic process;GO:1904224,negative regulation of glucuronosyltransferase activity;GO:0019222,regulation of metabolic process;GO:0042573,retinoic acid metabolic process;GO:0052697,xenobiotic glucuronidation;GO:0006805,xenobiotic metabolic process	hsa:54600,path:hsa00040,Pentose and glucuronate interconversions;hsa:54600,path:hsa00053,Ascorbate and aldarate metabolism;hsa:54600,path:hsa00140,Steroid hormone biosynthesis;hsa:54600,path:hsa00830,Retinol metabolism;hsa:54600,path:hsa00860,Porphyrin and chlorophyll metabolism;hsa:54600,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:54600,path:hsa00982,Drug metabolism - cytochrome P450;hsa:54600,path:hsa00983,Drug metabolism - other enzymes;hsa:54600,path:hsa05204,Chemical carcinogenesis
AN32A_HUMAN	P39687	ANP32A	Acidic leucine-rich nuclear phosphoprotein 32 family member A	3.611211817	5.919851868	1.310013331	0.397318741	4.7655318425	0.853666036	4.7655318425	0.853666036	5.58243111654029	0.052911	0	0.179133423973129	0.052510	0	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm	GO:0042393,histone binding;GO:0003723,RNA binding	GO:0035556,intracellular signal transduction;GO:0006913,nucleocytoplasmic transport;GO:0042981,regulation of apoptotic process;GO:0043488,regulation of mRNA stability;GO:0016032,viral process	
FMNL1_HUMAN	O95466	FMNL1	Formin-like protein 1	2.698604995	1.17606153	2.281465592	3.245087452	1.9373332625	2.763276522	1.9373332625	2.763276522	0.701100033628846	0.405806	0	1.42632998435911	0.406001	0	GO:0032059,bleb;GO:0005938,cell cortex;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0045335,phagocytic vesicle;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0051015,actin filament binding;GO:0032794,GTPase activating protein binding;GO:0031267,small GTPase binding;GO:0003779,actin binding	GO:0051014,actin filament severing;GO:0016477,cell migration;GO:0030866,cortical actin cytoskeleton organization;GO:0008360,regulation of cell shape;GO:0007010,cytoskeleton organization	
IMP3_HUMAN	Q9NV31	IMP3	U3 small nucleolar ribonucleoprotein protein IMP3	0.269507155	1.155262398	0.017518189	2.55E-05	0.7123847765	0.0087718445	0.7123847765	0.0087718445	81.2126544764901	0.000054	1	0.0123133519824732	0.000052	-1	GO:0034457,Mpp10 complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0030684,preribosome;GO:0032040,small-subunit processome	GO:0003723,RNA binding;GO:0019843,rRNA binding;GO:0030515,snoRNA binding	GO:0006364,rRNA processing	hsa:55272,path:hsa03008,Ribosome biogenesis in eukaryotes
CO6A2_HUMAN	P12110	COL6A2	Collagen alpha-2(VI) chain	24.08006052	19.59944166	30.25982578	284.0566138	21.83975109	157.15821979	21.83975109	157.15821979	0.138966648509909	0.003348	-1	7.19597119684939	0.003382	1	GO:0005581,collagen trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1903561,extracellular vesicle;GO:0032991,protein-containing complex;GO:0042383,sarcolemma	GO:0005518,collagen binding;GO:0030020,extracellular matrix structural constituent conferring tensile strength	GO:0007155,cell adhesion;GO:0030199,collagen fibril organization;GO:0030198,extracellular matrix organization;GO:0009749,response to glucose	hsa:1292,path:hsa04151,PI3K-Akt signaling pathway;hsa:1292,path:hsa04512,ECM-receptor interaction;hsa:1292,path:hsa04510,Focal adhesion;hsa:1292,path:hsa04974,Protein digestion and absorption;hsa:1292,path:hsa05165,Human papillomavirus infection
CP20A_HUMAN	Q6UW02	CYP20A1	Cytochrome P450 20A1	0.34698278	0.580828268	0.200097347	0.166272274	0.463905524	0.1831848105	0.463905524	0.1831848105	2.53244536342166	0.170796	0	0.394875251582475	0.170226	0	GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0020037,heme binding;GO:0005506,iron ion binding;GO:0004497,monooxygenase activity;GO:0016705,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen		
DJC13_HUMAN	O75165	DNAJC13	DnaJ homolog subfamily C member 13	0.517158777	0.597100286	1.023367016	0.932978222	0.5571295315	0.978172619	0.5571295315	0.978172619	0.569561568866609	0.289145	0	1.75573643774796	0.289441	0	GO:0035577,azurophil granule membrane;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0016021,integral component of membrane		GO:0007032,endosome organization;GO:0043312,neutrophil degranulation;GO:0001649,osteoblast differentiation;GO:0015031,protein transport;GO:0006898,receptor-mediated endocytosis;GO:2000641,regulation of early endosome to late endosome transport;GO:1902954,regulation of early endosome to recycling endosome transport	
IMB1_HUMAN	Q14974	KPNB1	Importin subunit beta-1	10.76884221	6.193871988	11.78450989	11.0687118	8.481357099	11.426610845	8.481357099	11.426610845	0.742246079266034	0.439912	0	1.34726208454862	0.440070	0	GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0071782,endoplasmic reticulum tubular network;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0043657,host cell;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0005643,nuclear pore;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0035580,specific granule lumen;GO:0032991,protein-containing complex	GO:0019899,enzyme binding;GO:0061608,nuclear import signal receptor activity;GO:0008139,nuclear localization sequence binding;GO:0019904,protein domain specific binding;GO:0003723,RNA binding;GO:0031267,small GTPase binding;GO:0008270,zinc ion binding;GO:0051879,Hsp90 protein binding;GO:0061676,importin-alpha family protein binding	GO:0006309,apoptotic DNA fragmentation;GO:0030953,astral microtubule organization;GO:0040001,establishment of mitotic spindle localization;GO:0045184,establishment of protein localization;GO:0075733,intracellular transport of virus;GO:0007079,mitotic chromosome movement towards spindle pole;GO:0007080,mitotic metaphase plate congression;GO:0007084,mitotic nuclear envelope reassembly;GO:0090307,mitotic spindle assembly;GO:0019054,modulation by virus of host cellular process;GO:0043312,neutrophil degranulation;GO:0006607,NLS-bearing protein import into nucleus;GO:0006606,protein import into nucleus;GO:0031291,Ran protein signal transduction;GO:0045540,regulation of cholesterol biosynthetic process;GO:0006610,ribosomal protein import into nucleus	hsa:3837,path:hsa03013,RNA transport
RTRAF_HUMAN	Q9Y224	RTRAF	RNA transcription, translation and transport factor protein	0.240134449	0.08347632	0.24455843	0.150174609	0.1618053845	0.1973665195	0.1618053845	0.1973665195	0.819821846734243	0.499841	0	1.21977720401511	0.499791	0	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0072686,mitotic spindle;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0072669,tRNA-splicing ligase complex	GO:0042802,identical protein binding;GO:0003723,RNA binding;GO:0000993,RNA polymerase II complex binding	GO:0006469,negative regulation of protein kinase activity;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0050658,RNA transport;GO:0006388,tRNA splicing, via endonucleolytic cleavage and ligation;GO:0016032,viral process	
HXK1_HUMAN	P19367	HK1	Hexokinase-1	11.51206934	13.72266413	14.9844737	12.1251072	12.617366735	13.55479045	12.617366735	13.55479045	0.930841888079502	0.457218	0	1.07429630402988	0.457073	0	GO:0005829,cytosol;GO:0045121,membrane raft;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0008865,fructokinase activity;GO:0004340,glucokinase activity;GO:0047931,glucosamine kinase activity;GO:0005536,glucose binding;GO:0004396,hexokinase activity;GO:0019158,mannokinase activity;GO:0042834,peptidoglycan binding	GO:0061621,canonical glycolysis;GO:0046835,carbohydrate phosphorylation;GO:0001678,cellular glucose homeostasis;GO:0072655,establishment of protein localization to mitochondrion;GO:0006002,fructose 6-phosphate metabolic process;GO:0051156,glucose 6-phosphate metabolic process;GO:0006096,glycolytic process;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0072656,maintenance of protein location in mitochondrion;GO:0006013,mannose metabolic process;GO:0002720,positive regulation of cytokine production involved in immune response;GO:0032731,positive regulation of interleukin-1 beta production;GO:0019318,hexose metabolic process	hsa:3098,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:3098,path:hsa00051,Fructose and mannose metabolism;hsa:3098,path:hsa00052,Galactose metabolism;hsa:3098,path:hsa00500,Starch and sucrose metabolism;hsa:3098,path:hsa00520,Amino sugar and nucleotide sugar metabolism;hsa:3098,path:hsa00524,Neomycin, kanamycin and gentamicin biosynthesis;hsa:3098,path:hsa04066,HIF-1 signaling pathway;hsa:3098,path:hsa04910,Insulin signaling pathway;hsa:3098,path:hsa04973,Carbohydrate digestion and absorption;hsa:3098,path:hsa05230,Central carbon metabolism in cancer;hsa:3098,path:hsa04930,Type II diabetes mellitus;hsa:3098,path:hsa05131,Shigellosis
TCPD_HUMAN	P50991	CCT4	T-complex protein 1 subunit delta	16.77542459	11.10535454	17.47094283	14.46945644	13.940389565	15.970199635	13.940389565	15.970199635	0.872900144244189	0.478757	0	1.14560640938588	0.478659	0	GO:0044297,cell body;GO:0042995,cell projection;GO:0005813,centrosome;GO:0005832,chaperonin-containing T-complex;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0042470,melanosome;GO:0005874,microtubule;GO:0005654,nucleoplasm;GO:0002199,zona pellucida receptor complex	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0044183,protein folding chaperone;GO:0003723,RNA binding;GO:0051082,unfolded protein binding	GO:0007339,binding of sperm to zona pellucida;GO:1904851,positive regulation of establishment of protein localization to telomere;GO:1904871,positive regulation of protein localization to Cajal body;GO:0051973,positive regulation of telomerase activity;GO:1904874,positive regulation of telomerase RNA localization to Cajal body;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:0006457,protein folding;GO:0050821,protein stabilization;GO:0090666,scaRNA localization to Cajal body;GO:1901998,toxin transport	
MED1_HUMAN	Q15648	MED1	Mediator of RNA polymerase II transcription subunit 1	0.047123969	0.025814053	0.087656372	2.55E-05	0.036469011	0.043840936	0.036469011	0.043840936	0.831848366558597	0.494944	0	1.20214216941611	0.494883	0	GO:0000785,chromatin;GO:0016592,mediator complex;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032993,protein-DNA complex;GO:0000151,ubiquitin ligase complex	GO:0003682,chromatin binding;GO:0031490,chromatin DNA binding;GO:0030331,estrogen receptor binding;GO:0050693,LBD domain binding;GO:0035257,nuclear hormone receptor binding;GO:0016922,nuclear receptor binding;GO:0030374,nuclear receptor coactivator activity;GO:0042975,peroxisome proliferator activated receptor binding;GO:1990841,promoter-specific chromatin binding;GO:0044877,protein-containing complex binding;GO:0042974,retinoic acid receptor binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0046966,thyroid hormone receptor binding;GO:0003713,transcription coactivator activity;GO:0003712,transcription coregulator activity;GO:0003714,transcription corepressor activity;GO:0008134,transcription factor binding;GO:0061630,ubiquitin protein ligase activity;GO:0042809,vitamin D receptor binding	GO:0006702,androgen biosynthetic process;GO:0001525,angiogenesis;GO:0031100,animal organ regeneration;GO:0007420,brain development;GO:0000902,cell morphogenesis;GO:0071364,cellular response to epidermal growth factor stimulus;GO:0035729,cellular response to hepatocyte growth factor stimulus;GO:0071383,cellular response to steroid hormone stimulus;GO:0097067,cellular response to thyroid hormone stimulus;GO:0035050,embryonic heart tube development;GO:0035162,embryonic hemopoiesis;GO:0035116,embryonic hindlimb morphogenesis;GO:0001892,embryonic placenta development;GO:0048822,enucleate erythrocyte development;GO:0060750,epithelial cell proliferation involved in mammary gland duct elongation;GO:0048821,erythrocyte development;GO:0045444,fat cell differentiation;GO:0030518,intracellular steroid hormone receptor signaling pathway;GO:0030216,keratinocyte differentiation;GO:0007595,lactation;GO:0002088,lens development in camera-type eye;GO:0001889,liver development;GO:0060745,mammary gland branching involved in pregnancy;GO:0060744,mammary gland branching involved in thelarche;GO:0035855,megakaryocyte development;GO:0030224,monocyte differentiation;GO:0042789,mRNA transcription by RNA polymerase II;GO:0043066,negative regulation of apoptotic process;GO:0010839,negative regulation of keratinocyte proliferation;GO:0045665,negative regulation of neuron differentiation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0035357,peroxisome proliferator activated receptor signaling pathway;GO:0045648,positive regulation of erythrocyte differentiation;GO:0070318,positive regulation of G0 to G1 transition;GO:0010628,positive regulation of gene expression;GO:2000347,positive regulation of hepatocyte proliferation;GO:0060335,positive regulation of interferon-gamma-mediated signaling pathway;GO:0033148,positive regulation of intracellular estrogen receptor signaling pathway;GO:0045618,positive regulation of keratinocyte differentiation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0060261,positive regulation of transcription initiation from RNA polymerase II promoter;GO:0045893,positive regulation of transcription, DNA-templated;GO:0006606,protein import into nucleus;GO:0019216,regulation of lipid metabolic process;GO:2001141,regulation of RNA biosynthetic process;GO:0006357,regulation of transcription by RNA polymerase II;GO:0060260,regulation of transcription initiation from RNA polymerase II promoter;GO:0070562,regulation of vitamin D receptor signaling pathway;GO:0003406,retinal pigment epithelium development;GO:0006590,thyroid hormone generation;GO:0002154,thyroid hormone mediated signaling pathway;GO:0006367,transcription initiation from RNA polymerase II promoter;GO:0003222,ventricular trabecula myocardium morphogenesis	hsa:5469,path:hsa04919,Thyroid hormone signaling pathway;hsa:5469,path:hsa01522,Endocrine resistance
MICA1_HUMAN	Q8TDZ2	MICAL1	[F-actin]-monooxygenase MICAL1	0.426831672	0.739092956	0.955120761	0.815346824	0.582962314	0.8852337925	0.582962314	0.8852337925	0.658540510923842	0.369171	0	1.51850946663424	0.369401	0	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:1990026,hippocampal mossy fiber expansion;GO:0045171,intercellular bridge;GO:0005882,intermediate filament;GO:0030496,midbody;GO:0005886,plasma membrane	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0071949,FAD binding;GO:0046872,metal ion binding;GO:0016174,NAD(P)H oxidase H2O2-forming activity;GO:0016709,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0019901,protein kinase binding;GO:0017124,SH3 domain binding;GO:0031267,small GTPase binding;GO:0004497,monooxygenase activity	GO:0051017,actin filament bundle assembly;GO:0030042,actin filament depolymerization;GO:0007596,blood coagulation;GO:0007010,cytoskeleton organization;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0001933,negative regulation of protein phosphorylation;GO:1903305,regulation of regulated secretory pathway;GO:0007165,signal transduction;GO:0019417,sulfur oxidation	
CSTF2_HUMAN	P33240	CSTF2	Cleavage stimulation factor subunit 2	0.462238247	0.572430731	0.736435226	0.161705214	0.517334489	0.44907022	0.517334489	0.44907022	1.15201246032302	0.387009	0	0.868046166548931	0.386716	0	GO:0071920,cleavage body;GO:0005847,mRNA cleavage and polyadenylation specificity factor complex;GO:0016604,nuclear body;GO:0005654,nucleoplasm	GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0031124,mRNA 3'-end processing;GO:0006378,mRNA polyadenylation;GO:0000398,mRNA splicing, via spliceosome;GO:0098789,pre-mRNA cleavage required for polyadenylation;GO:0006369,termination of RNA polymerase II transcription;GO:0006388,tRNA splicing, via endonucleolytic cleavage and ligation;GO:1990090,cellular response to nerve growth factor stimulus	hsa:1478,path:hsa03015,mRNA surveillance pathway
PRS7_HUMAN	P35998	PSMC2	26S proteasome regulatory subunit 7	4.425147993	3.861465629	5.506387044	5.22062987	4.143306811	5.363508457	4.143306811	5.363508457	0.77249935265647	0.464088	0	1.29449946664836	0.464220	0	GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body;GO:0022624,proteasome accessory complex;GO:0000502,proteasome complex;GO:0008540,proteasome regulatory particle, base subcomplex;GO:0034774,secretory granule lumen	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0036402,proteasome-activating ATPase activity;GO:0017025,TBP-class protein binding	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0043312,neutrophil degranulation;GO:0038061,NIK/NF-kappaB signaling;GO:0001649,osteoblast differentiation;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0045899,positive regulation of RNA polymerase II transcription preinitiation complex assembly;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5701,path:hsa03050,Proteasome;hsa:5701,path:hsa05169,Epstein-Barr virus infection
ADT3_HUMAN	P12236	SLC25A6	ADP/ATP translocase 3	4.02345158	4.416583976	5.945107888	2.707825913	4.220017778	4.3264669005	4.220017778	4.3264669005	0.975395831067678	0.441625	0	1.02522480427806	0.441446	0	GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005744,TIM23 mitochondrial import inner membrane translocase complex	GO:0005471,ATP	GO:0006915,apoptotic process;GO:0140021,mitochondrial ADP transmembrane transport;GO:1990544,mitochondrial ATP transmembrane transport;GO:0006626,protein targeting to mitochondrion;GO:0016032,viral process	hsa:293,path:hsa04020,Calcium signaling pathway;hsa:293,path:hsa04022,cGMP-PKG signaling pathway;hsa:293,path:hsa04217,Necroptosis;hsa:293,path:hsa04218,Cellular senescence;hsa:293,path:hsa05012,Parkinson disease;hsa:293,path:hsa05016,Huntington disease;hsa:293,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:293,path:hsa05164,Influenza A
RABP2_HUMAN	P29373	CRABP2	Cellular retinoic acid-binding protein 2	3.096458598	2.09050474	0.639133261	1.478756178	2.593481669	1.0589447195	2.593481669	1.0589447195	2.44911903448988	0.178049	0	0.40831008453139	0.177480	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0030332,cyclin binding;GO:0016918,retinal binding;GO:0001972,retinoic acid binding;GO:0005501,retinoid binding;GO:0019841,retinol binding;GO:0008289,lipid binding	GO:0035115,embryonic forelimb morphogenesis;GO:0008544,epidermis development;GO:0048672,positive regulation of collateral sprouting;GO:0006355,regulation of transcription, DNA-templated;GO:0042573,retinoic acid metabolic process;GO:0007165,signal transduction	
NAT10_HUMAN	Q9H0A0	NAT10	RNA cytidine acetyltransferase	0.33291692	0.147598252	0.416176924	0.262993323	0.240257586	0.3395851235	0.240257586	0.3395851235	0.70750327200361	0.411203	0	1.41342102513258	0.411391	0	GO:0000781,chromosome, telomeric region;GO:0016020,membrane;GO:0030496,midbody;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005697,telomerase holoenzyme complex	GO:0005524,ATP binding;GO:0070182,DNA polymerase binding;GO:0106162,mRNA N-acetyltransferase activity;GO:0008080,N-acetyltransferase activity;GO:0003723,RNA binding;GO:1990883,rRNA cytidine N-acetyltransferase activity;GO:0000049,tRNA binding	GO:0032211,negative regulation of telomere maintenance via telomerase;GO:0045727,positive regulation of translation;GO:0006473,protein acetylation;GO:0010824,regulation of centrosome duplication;GO:1904812,rRNA acetylation involved in maturation of SSU-rRNA;GO:0000154,rRNA modification;GO:0051391,tRNA acetylation;GO:0042274,ribosomal small subunit biogenesis	hsa:55226,path:hsa03008,Ribosome biogenesis in eukaryotes
GALT3_HUMAN	Q14435	GALNT3	Polypeptide N-acetylgalactosaminyltransferase 3	0.110091373	0.09250236	0.179507007	0.132885988	0.1012968665	0.1561964975	0.1012968665	0.1561964975	0.648522009912546	0.360367	0	1.54196771229839	0.360606	0	GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0032580,Golgi cisterna membrane;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm	GO:0005509,calcium ion binding;GO:0030246,carbohydrate binding;GO:0030145,manganese ion binding;GO:0004653,polypeptide N-acetylgalactosaminyltransferase activity;GO:0016740,transferase activity	GO:0005975,carbohydrate metabolic process;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0016266,O-glycan processing;GO:0018242,protein O-linked glycosylation via serine;GO:0018243,protein O-linked glycosylation via threonine	hsa:2591,path:hsa00512,Mucin type O-glycan biosynthesis;hsa:2591,path:hsa00514,Other types of O-glycan biosynthesis
SSBP_HUMAN	Q04837	SSBP1	Single-stranded DNA-binding protein, mitochondrial	10.29148265	19.4054438	1.558850845	0.638008772	14.848463225	1.0984298085	14.848463225	1.0984298085	13.5178990137539	0.009072	1	0.0739759927916715	0.008940	-1	GO:0070062,extracellular exosome;GO:0005759,mitochondrial matrix;GO:0042645,mitochondrial nucleoid;GO:0005739,mitochondrion;GO:0009295,nucleoid;GO:0005634,nucleus	GO:0003682,chromatin binding;GO:0042802,identical protein binding;GO:0003723,RNA binding;GO:0003697,single-stranded DNA binding	GO:0006268,DNA unwinding involved in DNA replication;GO:0006264,mitochondrial DNA replication;GO:0070584,mitochondrion morphogenesis;GO:0007005,mitochondrion organization;GO:1905776,positive regulation of DNA helicase activity;GO:0051096,positive regulation of helicase activity;GO:0006260,DNA replication	hsa:6742,path:hsa03030,DNA replication;hsa:6742,path:hsa03430,Mismatch repair;hsa:6742,path:hsa03440,Homologous recombination
EI2BG_HUMAN	Q9NR50	EIF2B3	Translation initiation factor eIF-2B subunit gamma	0.131232465	0.236111966	0.324200322	0.246598244	0.1836722155	0.285399283	0.1836722155	0.285399283	0.643562287786126	0.355986	0	1.55385114848794	0.356228	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005851,eukaryotic translation initiation factor 2B complex;GO:0032045,guanyl-nucleotide exchange factor complex	GO:0005085,guanyl-nucleotide exchange factor activity;GO:0003743,translation initiation factor activity;GO:0016779,nucleotidyltransferase activity	GO:0002183,cytoplasmic translational initiation;GO:0021766,hippocampus development;GO:0014003,oligodendrocyte development;GO:0009749,response to glucose;GO:0009408,response to heat;GO:0043434,response to peptide hormone;GO:0050852,T cell receptor signaling pathway;GO:0006413,translational initiation;GO:0009058,biosynthetic process	hsa:8891,path:hsa03013,RNA transport;hsa:8891,path:hsa05168,Herpes simplex virus 1 infection
FCL_HUMAN	Q13630	GFUS	GDP-L-fucose synthase	1.693363342	3.008724536	3.509325529	6.208753037	2.351043939	4.859039283	2.351043939	4.859039283	0.483849543514794	0.210374	0	2.06675817597299	0.210706	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0009055,electron transfer activity;GO:0042356,GDP-4-dehydro-D-rhamnose reductase activity;GO:0050577,GDP-L-fucose synthase activity;GO:0047918,GDP-mannose 3,5-epimerase activity;GO:0042802,identical protein binding;GO:0003824,catalytic activity	GO:0042351,'de novo' GDP-L-fucose biosynthetic process;GO:0019673,GDP-mannose metabolic process;GO:0007159,leukocyte cell-cell adhesion;GO:0010595,positive regulation of endothelial cell migration;GO:1904906,positive regulation of endothelial cell-matrix adhesion via fibronectin	hsa:7264,path:hsa00051,Fructose and mannose metabolism;hsa:7264,path:hsa00520,Amino sugar and nucleotide sugar metabolism
OXSR1_HUMAN	O95747	OXSR1	Serine/threonine-protein kinase OSR1	1.136230888	0.861805064	1.546008607	1.634142802	0.999017976	1.5900757045	0.999017976	1.5900757045	0.628283278068286	0.342397	0	1.59163873193409	0.342652	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0000287,magnesium ion binding;GO:0019901,protein kinase binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity	GO:0071476,cellular hypotonic response;GO:1990869,cellular response to chemokine;GO:0038116,chemokine (C-C motif) ligand 21 signaling pathway;GO:0038146,chemokine (C-X-C motif) ligand 12 signaling pathway;GO:0035556,intracellular signal transduction;GO:1901017,negative regulation of potassium ion transmembrane transporter activity;GO:0007231,osmosensory signaling pathway;GO:0018107,peptidyl-threonine phosphorylation;GO:0010820,positive regulation of T cell chemotaxis;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:0006979,response to oxidative stress;GO:0007165,signal transduction	
UMPS_HUMAN	P11172	UMPS	Uridine 5'-monophosphate synthase	0.787788776	1.097549278	1.325175132	0.837555238	0.942669027	1.081365185	0.942669027	1.081365185	0.871739760144026	0.479203	0	1.14713134093457	0.479107	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus	GO:0042802,identical protein binding;GO:0004588,orotate phosphoribosyltransferase activity;GO:0004590,orotidine-5'-phosphate decarboxylase activity	GO:0006207,'de novo' pyrimidine nucleobase biosynthetic process;GO:0044205,'de novo' UMP biosynthetic process;GO:0035690,cellular response to drug;GO:0007565,female pregnancy;GO:0007595,lactation;GO:0019856,pyrimidine nucleobase biosynthetic process;GO:0046134,pyrimidine nucleoside biosynthetic process;GO:0006222,UMP biosynthetic process;GO:0009116,nucleoside metabolic process	hsa:7372,path:hsa00240,Pyrimidine metabolism;hsa:7372,path:hsa00983,Drug metabolism - other enzymes
RUFY1_HUMAN	Q96T51	RUFY1	RUN and FYVE domain-containing protein 1	0.394091351	0.551784566	0.256027504	0.515502861	0.4729379585	0.3857651825	0.4729379585	0.3857651825	1.22597367506073	0.367090	0	0.815678199575093	0.366757	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0005768,endosome;GO:0043231,intracellular membrane-bounded organelle;GO:0016607,nuclear speck	GO:0042802,identical protein binding;GO:0008289,lipid binding;GO:0046872,metal ion binding;GO:0042169,SH2 domain binding;GO:0017124,SH3 domain binding	GO:0006897,endocytosis;GO:0006661,phosphatidylinositol biosynthetic process;GO:0015031,protein transport;GO:0030100,regulation of endocytosis;GO:0007264,small GTPase mediated signal transduction	hsa:80230,path:hsa04144,Endocytosis
TKFC_HUMAN	Q3LXA3	TKFC	Triokinase/FMN cyclase	1.046530065	0.873224654	1.57265282	0.608600077	0.9598773595	1.0906264485	0.9598773595	1.0906264485	0.880115607704337	0.475993	0	1.13621436916494	0.475889	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0034012,FAD-AMP lyase (cyclizing) activity;GO:0004371,glycerone kinase activity;GO:0046872,metal ion binding;GO:0050354,triokinase activity	GO:0046835,carbohydrate phosphorylation;GO:0044262,cellular carbohydrate metabolic process;GO:0061624,fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate;GO:0019563,glycerol catabolic process;GO:0045087,innate immune response;GO:0039534,negative regulation of MDA-5 signaling pathway;GO:0045088,regulation of innate immune response;GO:0006071,glycerol metabolic process	hsa:26007,path:hsa00051,Fructose and mannose metabolism;hsa:26007,path:hsa00561,Glycerolipid metabolism;hsa:26007,path:hsa04622,RIG-I-like receptor signaling pathway
MGAT1_HUMAN	P26572	MGAT1	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	0.309316361	0.323030015	0.507830542	0.169236155	0.316173188	0.3385333485	0.316173188	0.3385333485	0.933949903018196	0.456104	0	1.07072124186571	0.455957	0	GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0070062,extracellular exosome;GO:1903561,extracellular vesicle;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm	GO:0003827,alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity;GO:0030145,manganese ion binding;GO:0008375,acetylglucosaminyltransferase activity;GO:0046872,metal ion binding	GO:0001701,in utero embryonic development;GO:0006486,protein glycosylation;GO:0006487,protein N-linked glycosylation;GO:0018279,protein N-linked glycosylation via asparagine;GO:0006049,UDP-N-acetylglucosamine catabolic process;GO:0019082,viral protein processing	hsa:4245,path:hsa00510,N-Glycan biosynthesis;hsa:4245,path:hsa00513,Various types of N-glycan biosynthesis
TARSH_HUMAN	Q7Z7G0	ABI3BP	Target of Nesh-SH3	2.55E-05	0.104871485	0.146556931	1.255672607	0.0524484925	0.701114769	0.0524484925	0.701114769	0.0748072852249387	0.000127	-1	13.3676819977238	0.000129	1	GO:0062023,collagen-containing extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005614,interstitial matrix	GO:0005518,collagen binding;GO:0008201,heparin binding	GO:0030198,extracellular matrix organization;GO:0008285,negative regulation of cell population proliferation;GO:1904597,negative regulation of connective tissue replacement involved in inflammatory response wound healing;GO:1905209,positive regulation of cardiocyte differentiation;GO:0010811,positive regulation of cell-substrate adhesion	
LYPL1_HUMAN	Q5VWZ2	LYPLAL1	Lysophospholipase-like protein 1	1.256656308	0.913227366	0.838466956	0.179598981	1.084941837	0.5090329685	1.084941837	0.5090329685	2.13137832741378	0.210208	0	0.469179960750283	0.209653	0	GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0052689,carboxylic ester hydrolase activity;GO:0004622,lysophospholipase activity;GO:0008474,palmitoyl-(protein) hydrolase activity	GO:0002084,protein depalmitoylation	
LMAN1_HUMAN	P49257	LMAN1	Protein ERGIC-53	8.985020591	6.194312379	14.12669286	6.982003255	7.589666485	10.5543480575	7.589666485	10.5543480575	0.719103296921	0.420897	0	1.39062079715351	0.421076	0	GO:0062023,collagen-containing extracellular matrix;GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0070062,extracellular exosome;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0030017,sarcomere	GO:0005537,mannose binding;GO:0046872,metal ion binding;GO:0051082,unfolded protein binding	GO:0007596,blood coagulation;GO:0048208,COPII vesicle coating;GO:0007029,endoplasmic reticulum organization;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030,Golgi organization;GO:1903215,negative regulation of protein targeting to mitochondrion;GO:0010638,positive regulation of organelle organization;GO:0006457,protein folding;GO:0018279,protein N-linked glycosylation via asparagine;GO:0015031,protein transport	hsa:3998,path:hsa04141,Protein processing in endoplasmic reticulum
SNG2_HUMAN	O43760	SYNGR2	Synaptogyrin-2	3.759855684	20.09383157	3.700573675	1.47221697	11.926843627	2.5863953225	11.926843627	2.5863953225	4.61137689325527	0.072670	0	0.2168549704672	0.072205	0	GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005811,lipid droplet;GO:0031594,neuromuscular junction;GO:0030672,synaptic vesicle membrane		GO:0045055,regulated exocytosis;GO:0048499,synaptic vesicle membrane organization;GO:0016032,viral process	
HBD_HUMAN	P02042	HBD	Hemoglobin subunit delta	7.869861974	101.1799507	22.13368644	383.068224	54.524906337	202.60095522	54.524906337	202.60095522	0.269124626178552	0.044417	-1	3.71575063270704	0.044622	1	GO:0072562,blood microparticle;GO:0005829,cytosol;GO:0031838,haptoglobin-hemoglobin complex;GO:0005833,hemoglobin complex;GO:0016021,integral component of membrane	GO:0020037,heme binding;GO:0031721,hemoglobin alpha binding;GO:0046872,metal ion binding;GO:0043177,organic acid binding;GO:0019825,oxygen binding;GO:0005344,oxygen carrier activity	GO:0007596,blood coagulation;GO:0098869,cellular oxidant detoxification;GO:0042744,hydrogen peroxide catabolic process	
TCPH_HUMAN	Q99832	CCT7	T-complex protein 1 subunit eta	11.4250898	4.559348912	11.15723925	9.885647317	7.992219356	10.5214432835	7.992219356	10.5214432835	0.759612454361048	0.453887	0	1.31646077451581	0.454029	0	GO:0044297,cell body;GO:0005832,chaperonin-containing T-complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005874,microtubule	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0042802,identical protein binding;GO:0044183,protein folding chaperone;GO:0051082,unfolded protein binding	GO:0007339,binding of sperm to zona pellucida;GO:1904851,positive regulation of establishment of protein localization to telomere;GO:1904871,positive regulation of protein localization to Cajal body;GO:1904874,positive regulation of telomerase RNA localization to Cajal body;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:0006457,protein folding;GO:0050821,protein stabilization;GO:1901998,toxin transport	
KISHA_HUMAN	Q8TBQ9	TMEM167A	Protein kish-A	1.28005816	0.992539685	0.753514815	0.540391773	1.1362989225	0.646953294	1.1362989225	0.646953294	1.75638478548345	0.260243	0	0.56935132225297	0.259736	0	GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane		GO:0045054,constitutive secretory pathway;GO:0046907,intracellular transport;GO:0009306,protein secretion	
ROA3_HUMAN	P51991	HNRNPA3	Heterogeneous nuclear ribonucleoprotein A3	7.709368871	8.578968524	12.45524625	6.228493729	8.1441686975	9.3418699895	8.1441686975	9.3418699895	0.871792125843521	0.479183	0	1.14706243650965	0.479086	0	GO:0071013,catalytic step 2 spliceosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex	GO:0003723,RNA binding	GO:0000398,mRNA splicing, via spliceosome;GO:0016070,RNA metabolic process	hsa:220988,path:hsa03040,Spliceosome
NEUR1_HUMAN	Q99519	NEU1	Sialidase-1	0.21710524	0.121249689	0.154968903	0.078125716	0.1691774645	0.1165473095	0.1691774645	0.1165473095	1.45157760591633	0.314923	0	0.68890564026629	0.314497	0	GO:0030054,cell junction;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0043231,intracellular membrane-bounded organelle;GO:0043202,lysosomal lumen;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0035580,specific granule lumen;GO:0016021,integral component of membrane	GO:0016997,alpha-sialidase activity;GO:0052794,exo-alpha-(2->3)-sialidase activity;GO:0052795,exo-alpha-(2->6)-sialidase activity;GO:0052796,exo-alpha-(2->8)-sialidase activity;GO:0004308,exo-alpha-sialidase activity	GO:0006689,ganglioside catabolic process;GO:0006687,glycosphingolipid metabolic process;GO:0043312,neutrophil degranulation;GO:0009313,oligosaccharide catabolic process;GO:0016042,lipid catabolic process	hsa:4758,path:hsa00600,Sphingolipid metabolism;hsa:4758,path:hsa00511,Other glycan degradation;hsa:4758,path:hsa04142,Lysosome
SEP10_HUMAN	Q9P0V9	SEPTIN10	Septin-10	0.268434506	0.301313874	0.477647812	1.391858994	0.28487419	0.934753403	0.28487419	0.934753403	0.304758655155171	0.065324	0	3.281284987594	0.065575	0	GO:0032153,cell division site;GO:0015630,microtubule cytoskeleton;GO:0031105,septin complex;GO:0005940,septin ring;GO:0005856,cytoskeleton	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0060090,molecular adaptor activity	GO:0034613,cellular protein localization;GO:0061640,cytoskeleton-dependent cytokinesis	
NDUS1_HUMAN	P28331	NDUFS1	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	5.853698074	3.335837768	8.255192536	5.557469847	4.594767921	6.9063311915	4.594767921	6.9063311915	0.665297940917608	0.375072	0	1.50308596870262	0.375297	0	GO:0005758,mitochondrial intermembrane space;GO:0005759,mitochondrial matrix;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion;GO:0005743,mitochondrial inner membrane;GO:0016020,membrane	GO:0051537,2 iron, 2 sulfur cluster binding;GO:0051539,4 iron, 4 sulfur cluster binding;GO:0009055,electron transfer activity;GO:0046872,metal ion binding;GO:0008137,NADH dehydrogenase (ubiquinone) activity;GO:0051536,iron-sulfur cluster binding	GO:0008637,apoptotic mitochondrial changes;GO:0046034,ATP metabolic process;GO:0045333,cellular respiration;GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0072593,reactive oxygen species metabolic process;GO:0051881,regulation of mitochondrial membrane potential;GO:0042773,ATP synthesis coupled electron transport	hsa:4719,path:hsa00190,Oxidative phosphorylation;hsa:4719,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4719,path:hsa04714,Thermogenesis;hsa:4719,path:hsa05010,Alzheimer disease;hsa:4719,path:hsa05012,Parkinson disease;hsa:4719,path:hsa05016,Huntington disease;hsa:4719,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
IFIT1_HUMAN	P09914	IFIT1	Interferon-induced protein with tetratricopeptide repeats 1	0.294758075	0.304475669	0.44752734	0.890747928	0.299616872	0.669137634	0.299616872	0.669137634	0.447765686423789	0.177856	0	2.23331092649549	0.178191	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043657,host cell	GO:0003723,RNA binding	GO:0140374,antiviral innate immune response;GO:0071360,cellular response to exogenous dsRNA;GO:0071357,cellular response to type I interferon;GO:0051607,defense response to virus;GO:0019060,intracellular transport of viral protein in host cell;GO:0051097,negative regulation of helicase activity;GO:0032091,negative regulation of protein binding;GO:0045071,negative regulation of viral genome replication;GO:0045070,positive regulation of viral genome replication;GO:0050688,regulation of defense response to virus;GO:0009615,response to virus;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process	hsa:3434,path:hsa05160,Hepatitis C
ACINU_HUMAN	Q9UKV3	ACIN1	Apoptotic chromatin condensation inducer in the nucleus	0.417501749	0.282382944	0.449031706	1.255456402	0.3499423465	0.852244054	0.3499423465	0.852244054	0.410612834266838	0.145497	0	2.43538417834779	0.145827	0	GO:0061574,ASAP complex;GO:0005829,cytosol;GO:0016607,nuclear speck;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0016887,ATPase activity;GO:0019899,enzyme binding;GO:0003676,nucleic acid binding;GO:0003723,RNA binding	GO:0030263,apoptotic chromosome condensation;GO:0030218,erythrocyte differentiation;GO:0006397,mRNA processing;GO:0048025,negative regulation of mRNA splicing, via spliceosome;GO:0043065,positive regulation of apoptotic process;GO:0045657,positive regulation of monocyte differentiation;GO:0008380,RNA splicing	hsa:22985,path:hsa03040,Spliceosome;hsa:22985,path:hsa03013,RNA transport;hsa:22985,path:hsa03015,mRNA surveillance pathway
PP2BB_HUMAN	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.013386168	2.55E-05	0.039762863	0.029314519	0.006705834	0.034538691	0.006705834	0.034538691	0.19415426021791	0.013883	-1	5.1505436907624	0.013981	1	GO:0005955,calcineurin complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0098978,glutamatergic synapse;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0030315,T-tubule;GO:0030018,Z disc	GO:0005509,calcium ion binding;GO:0005516,calmodulin binding;GO:0033192,calmodulin-dependent protein phosphatase activity;GO:0019899,enzyme binding;GO:0046983,protein dimerization activity;GO:0030346,protein phosphatase 2B binding;GO:0106306,protein serine phosphatase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0106307,protein threonine phosphatase activity;GO:0046872,metal ion binding	GO:0048675,axon extension;GO:0097720,calcineurin-mediated signaling;GO:0033173,calcineurin-NFAT signaling cascade;GO:0017156,calcium-ion regulated exocytosis;GO:0016311,dephosphorylation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0007507,heart development;GO:0007612,learning;GO:0031987,locomotion involved in locomotory behavior;GO:0001946,lymphangiogenesis;GO:0007613,memory;GO:0001915,negative regulation of T cell mediated cytotoxicity;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0006470,protein dephosphorylation;GO:0006468,protein phosphorylation;GO:0050796,regulation of insulin secretion;GO:0048167,regulation of synaptic plasticity;GO:1900242,regulation of synaptic vesicle endocytosis;GO:0034097,response to cytokine;GO:0007165,signal transduction;GO:0042110,T cell activation;GO:0030217,T cell differentiation;GO:0043029,T cell homeostasis;GO:0042098,T cell proliferation;GO:0007223,Wnt signaling pathway, calcium modulating pathway	hsa:5532,path:hsa04010,MAPK signaling pathway;hsa:5532,path:hsa04310,Wnt signaling pathway;hsa:5532,path:hsa04370,VEGF signaling pathway;hsa:5532,path:hsa04020,Calcium signaling pathway;hsa:5532,path:hsa04022,cGMP-PKG signaling pathway;hsa:5532,path:hsa04114,Oocyte meiosis;hsa:5532,path:hsa04218,Cellular senescence;hsa:5532,path:hsa04625,C-type lectin receptor signaling pathway;hsa:5532,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:5532,path:hsa04660,T cell receptor signaling pathway;hsa:5532,path:hsa04658,Th1 and Th2 cell differentiation;hsa:5532,path:hsa04659,Th17 cell differentiation;hsa:5532,path:hsa04662,B cell receptor signaling pathway;hsa:5532,path:hsa04922,Glucagon signaling pathway;hsa:5532,path:hsa04921,Oxytocin signaling pathway;hsa:5532,path:hsa04924,Renin secretion;hsa:5532,path:hsa04724,Glutamatergic synapse;hsa:5532,path:hsa04728,Dopaminergic synapse;hsa:5532,path:hsa04720,Long-term potentiation;hsa:5532,path:hsa04360,Axon guidance;hsa:5532,path:hsa04380,Osteoclast differentiation;hsa:5532,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:5532,path:hsa05010,Alzheimer disease;hsa:5532,path:hsa05014,Amyotrophic lateral sclerosis (ALS);hsa:5532,path:hsa05031,Amphetamine addiction;hsa:5532,path:hsa05152,Tuberculosis;hsa:5532,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:5532,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:5532,path:hsa05163,Human cytomegalovirus infection;hsa:5532,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection
SYYM_HUMAN	Q9Y2Z4	YARS2	Tyrosine--tRNA ligase, mitochondrial	0.145086571	0.094672429	0.215077395	0.117144703	0.1198795	0.166111049	0.1198795	0.166111049	0.721682878542294	0.423038	0	1.3856501653744	0.423215	0	GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0016604,nuclear body	GO:0005524,ATP binding;GO:0042803,protein homodimerization activity;GO:0003723,RNA binding;GO:0000049,tRNA binding;GO:0072545,tyrosine binding;GO:0004831,tyrosine-tRNA ligase activity	GO:0070184,mitochondrial tyrosyl-tRNA aminoacylation;GO:0006412,translation;GO:0043039,tRNA aminoacylation;GO:0006418,tRNA aminoacylation for protein translation;GO:0006437,tyrosyl-tRNA aminoacylation	hsa:51067,path:hsa00970,Aminoacyl-tRNA biosynthesis
CSN2_HUMAN	P61201	COPS2	COP9 signalosome complex subunit 2	0.97977769	0.698629791	1.36637566	1.062103339	0.8392037405	1.2142394995	0.8392037405	1.2142394995	0.691135266844447	0.397346	0	1.4468947657175	0.397549	0	GO:0008180,COP9 signalosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm	GO:0003714,transcription corepressor activity	GO:0001833,inner cell mass cell proliferation;GO:1903507,negative regulation of nucleic acid-templated transcription;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0030182,neuron differentiation;GO:0000715,nucleotide-excision repair, DNA damage recognition;GO:0043687,post-translational protein modification;GO:0000338,protein deneddylation;GO:0006468,protein phosphorylation;GO:0007165,signal transduction;GO:0035914,skeletal muscle cell differentiation;GO:0006366,transcription by RNA polymerase II;GO:0006283,transcription-coupled nucleotide-excision repair	
RUVB2_HUMAN	Q9Y230	RUVBL2	RuvB-like 2	4.224054316	3.708903336	5.138758574	5.455333725	3.966478826	5.2970461495	3.966478826	5.2970461495	0.74880956556786	0.445224	0	1.33545302568571	0.445376	0	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0120293,dynein axonemal particle;GO:0000791,euchromatin;GO:0070062,extracellular exosome;GO:0031011,Ino80 complex;GO:0016020,membrane;GO:0071339,MLL1 complex;GO:0035267,NuA4 histone acetyltransferase complex;GO:0016363,nuclear matrix;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0097255,R2TP complex;GO:1990904,ribonucleoprotein complex;GO:0000812,Swr1 complex	GO:0043139,5'-3' DNA helicase activity;GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0051117,ATPase binding;GO:0008013,beta-catenin binding;GO:0031490,chromatin DNA binding;GO:0003678,DNA helicase activity;GO:0042802,identical protein binding;GO:0140585,promoter-enhancer loop anchoring activity;GO:0042803,protein homodimerization activity;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000979,RNA polymerase II core promoter sequence-specific DNA binding;GO:0017025,TBP-class protein binding;GO:0001094,TFIID-class transcription factor complex binding;GO:0003714,transcription corepressor activity;GO:0051082,unfolded protein binding;GO:0016787,hydrolase activity	GO:0000492,box C/D snoRNP assembly;GO:0071392,cellular response to estradiol stimulus;GO:0034644,cellular response to UV;GO:0006338,chromatin remodeling;GO:0006310,DNA recombination;GO:0006281,DNA repair;GO:0071169,establishment of protein localization to chromatin;GO:0016573,histone acetylation;GO:0043968,histone H2A acetylation;GO:0043967,histone H4 acetylation;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0071899,negative regulation of estrogen receptor binding;GO:0035066,positive regulation of histone acetylation;GO:1904874,positive regulation of telomerase RNA localization to Cajal body;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0006457,protein folding;GO:0040008,regulation of growth;GO:0006357,regulation of transcription by RNA polymerase II	
MYPT1_HUMAN	O14974	PPP1R12A	Protein phosphatase 1 regulatory subunit 12A	1.233255413	0.938256907	1.117954419	1.828912833	1.08575616	1.473433626	1.08575616	1.473433626	0.736888408708001	0.435550	0	1.35705757911611	0.435712	0	GO:0031672,A band;GO:0015629,actin cytoskeleton;GO:0005813,centrosome;GO:0043292,contractile fiber;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0000776,kinetochore;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0072357,PTW/PP1 phosphatase complex;GO:0030018,Z disc	GO:0071889,14-3-3 protein binding;GO:0004857,enzyme inhibitor activity;GO:0019208,phosphatase regulator activity;GO:0019901,protein kinase binding	GO:0035690,cellular response to drug;GO:0007098,centrosome cycle;GO:0000086,G2/M transition of mitotic cell cycle;GO:0000278,mitotic cell cycle;GO:0043086,negative regulation of catalytic activity;GO:0035508,positive regulation of myosin-light-chain-phosphatase activity;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0006470,protein dephosphorylation;GO:0030155,regulation of cell adhesion;GO:0035507,regulation of myosin-light-chain-phosphatase activity;GO:0046822,regulation of nucleocytoplasmic transport;GO:0007165,signal transduction	hsa:4659,path:hsa04024,cAMP signaling pathway;hsa:4659,path:hsa04022,cGMP-PKG signaling pathway;hsa:4659,path:hsa04510,Focal adhesion;hsa:4659,path:hsa04810,Regulation of actin cytoskeleton;hsa:4659,path:hsa04611,Platelet activation;hsa:4659,path:hsa04921,Oxytocin signaling pathway;hsa:4659,path:hsa04270,Vascular smooth muscle contraction;hsa:4659,path:hsa05205,Proteoglycans in cancer
ACOX1_HUMAN	Q15067	ACOX1	Peroxisomal acyl-coenzyme A oxidase 1	0.572165846	0.910220479	0.714325425	0.233470938	0.7411931625	0.4738981815	0.7411931625	0.4738981815	1.56403462058864	0.292934	0	0.639372036166078	0.292472	0	GO:0005829,cytosol;GO:0016020,membrane;GO:0005782,peroxisomal matrix;GO:0005778,peroxisomal membrane;GO:0005777,peroxisome	GO:0003997,acyl-CoA oxidase activity;GO:0071949,FAD binding;GO:0005504,fatty acid binding;GO:0050660,flavin adenine dinucleotide binding;GO:0016401,palmitoyl-CoA oxidase activity;GO:0030165,PDZ domain binding;GO:0042803,protein homodimerization activity;GO:0047485,protein N-terminus binding;GO:0016627,oxidoreductase activity, acting on the CH-CH group of donors	GO:0036109,alpha-linolenic acid metabolic process;GO:0042632,cholesterol homeostasis;GO:0033540,fatty acid beta-oxidation using acyl-CoA oxidase;GO:0009062,fatty acid catabolic process;GO:0019395,fatty acid oxidation;GO:0006091,generation of precursor metabolites and energy;GO:0050665,hydrogen peroxide biosynthetic process;GO:0055088,lipid homeostasis;GO:0006629,lipid metabolic process;GO:0016559,peroxisome fission;GO:0006693,prostaglandin metabolic process;GO:0008104,protein localization;GO:0019222,regulation of metabolic process;GO:0007283,spermatogenesis;GO:0140493,very long-chain fatty acid beta-oxidation;GO:0000038,very long-chain fatty acid metabolic process;GO:0006635,fatty acid beta-oxidation	hsa:51,path:hsa00640,Propanoate metabolism;hsa:51,path:hsa00071,Fatty acid degradation;hsa:51,path:hsa00592,alpha-Linolenic acid metabolism;hsa:51,path:hsa01040,Biosynthesis of unsaturated fatty acids;hsa:51,path:hsa00410,beta-Alanine metabolism;hsa:51,path:hsa04024,cAMP signaling pathway;hsa:51,path:hsa04146,Peroxisome;hsa:51,path:hsa03320,PPAR signaling pathway
EHD4_HUMAN	Q9H223	EHD4	EH domain-containing protein 4	3.297153723	4.471884127	6.83654372	19.46401296	3.884518925	13.15027834	3.884518925	13.15027834	0.295394426229308	0.059469	0	3.38530422785879	0.059709	0	GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0030139,endocytic vesicle;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane	GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0005509,calcium ion binding;GO:0005525,GTP binding;GO:0003676,nucleic acid binding	GO:0071363,cellular response to growth factor stimulus;GO:0060271,cilium assembly;GO:0032456,endocytic recycling;GO:0006897,endocytosis;GO:0016197,endosomal transport;GO:0006907,pinocytosis;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0051260,protein homooligomerization;GO:0072659,protein localization to plasma membrane;GO:0030100,regulation of endocytosis	hsa:30844,path:hsa04144,Endocytosis
CAH12_HUMAN	O43570	CA12	Carbonic anhydrase 12	2.55E-05	2.55E-05	0.066417121	2.55E-05	2.55e-005	0.0332213105	2.55e-005	0.0332213105	0.000767579593225258	0.000000	-1	1302.79649019608	0.000000	1	GO:0016021,integral component of membrane;GO:0005886,plasma membrane	GO:0004089,carbonate dehydratase activity;GO:0016836,hydro-lyase activity;GO:0008270,zinc ion binding	GO:0015701,bicarbonate transport;GO:0055064,chloride ion homeostasis;GO:0006730,one-carbon metabolic process	hsa:771,path:hsa00910,Nitrogen metabolism
FCGRN_HUMAN	P55899	FCGRT	IgG receptor FcRn large subunit p51	0.093596274	0.593650828	0.59236647	0.741309133	0.343623551	0.6668378015	0.343623551	0.6668378015	0.515303047048391	0.239200	0	1.94060564114245	0.239524	0	GO:0010008,endosome membrane;GO:0009897,external side of plasma membrane;GO:0005615,extracellular space;GO:0016021,integral component of membrane	GO:0030881,beta-2-microglobulin binding;GO:0019864,IgG binding	GO:0002416,IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor	
ERLEC_HUMAN	Q96DZ1	ERLEC1	Endoplasmic reticulum lectin 1	0.188788835	0.10340576	0.280833349	0.051418205	0.1460972975	0.166125777	0.1460972975	0.166125777	0.879437858099529	0.476251	0	1.13709000674704	0.476148	0	GO:0005788,endoplasmic reticulum lumen;GO:0044322,endoplasmic reticulum quality control compartment	GO:0051082,unfolded protein binding	GO:0036503,ERAD pathway;GO:1904153,negative regulation of retrograde protein transport, ER to cytosol;GO:0055085,transmembrane transport;GO:0030433,ubiquitin-dependent ERAD pathway	hsa:27248,path:hsa04141,Protein processing in endoplasmic reticulum
DP13A_HUMAN	Q9UKG1	APPL1	DCC-interacting protein 13-alpha	0.94969302	0.652860864	0.820088263	2.212861345	0.801276942	1.516474804	0.801276942	1.516474804	0.528381308997996	0.251246	0	1.89257262316179	0.251564	0	GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0032009,early phagosome;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0097708,intracellular vesicle;GO:0044354,macropinosome;GO:0016020,membrane;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0001726,ruffle;GO:0012506,vesicle membrane	GO:0048487,beta-tubulin binding;GO:0042802,identical protein binding;GO:0035091,phosphatidylinositol binding;GO:0001786,phosphatidylserine binding;GO:0042803,protein homodimerization activity;GO:0043422,protein kinase B binding;GO:0044877,protein-containing complex binding	GO:0033211,adiponectin-activated signaling pathway;GO:0007049,cell cycle;GO:0035729,cellular response to hepatocyte growth factor stimulus;GO:0097192,extrinsic apoptotic signaling pathway in absence of ligand;GO:0008286,insulin receptor signaling pathway;GO:1905450,negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;GO:1900017,positive regulation of cytokine production involved in inflammatory response;GO:0046326,positive regulation of glucose import;GO:1905303,positive regulation of macropinocytosis;GO:0048023,positive regulation of melanin biosynthetic process;GO:0006606,protein import into nucleus;GO:0010762,regulation of fibroblast migration;GO:2000045,regulation of G1/S transition of mitotic cell cycle;GO:0046324,regulation of glucose import;GO:0045088,regulation of innate immune response;GO:1903076,regulation of protein localization to plasma membrane;GO:0034143,regulation of toll-like receptor 4 signaling pathway;GO:0007165,signal transduction;GO:0023052,signaling;GO:0007179,transforming growth factor beta receptor signaling pathway	hsa:26060,path:hsa04211,Longevity regulating pathway;hsa:26060,path:hsa05200,Pathways in cancer;hsa:26060,path:hsa05210,Colorectal cancer
B2L13_HUMAN	Q9BXK5	BCL2L13	Bcl-2-like protein 13	0.142066206	0.057561643	0.132142644	0.135373701	0.0998139245	0.1337581725	0.0998139245	0.1337581725	0.746226736164476	0.443138	0	1.34007527677163	0.443293	0	GO:0016021,integral component of membrane;GO:0031966,mitochondrial membrane;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0008656,cysteine-type endopeptidase activator activity involved in apoptotic process	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006915,apoptotic process;GO:0042981,regulation of apoptotic process	hsa:23786,path:hsa04137,Mitophagy - animal;hsa:23786,path:hsa05134,Legionellosis
AAPK1_HUMAN	Q13131	PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1	0.669339504	0.48052224	1.33082389	1.02824936	0.574930872	1.179536625	0.574930872	1.179536625	0.487420958208907	0.213631	0	2.05161469394881	0.213962	0	GO:0016324,apical plasma membrane;GO:0030424,axon;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0043025,neuronal cell body;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0031588,nucleotide-activated protein kinase complex;GO:0005634,nucleus	GO:0050405,[acetyl-CoA carboxylase] kinase activity;GO:0047322,[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity;GO:0004679,AMP-activated protein kinase activity;GO:0005524,ATP binding;GO:0004691,cAMP-dependent protein kinase activity;GO:0003682,chromatin binding;GO:0035174,histone serine kinase activity;GO:0046872,metal ion binding;GO:0008022,protein C-terminus binding;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0044877,protein-containing complex binding;GO:0048156,tau protein binding;GO:0050321,tau-protein kinase activity	GO:0000187,activation of MAPK activity;GO:0015721,bile acid and bile salt transport;GO:0038183,bile acid signaling pathway;GO:0061762,CAMKK-AMPK signaling cascade;GO:0007050,cell cycle arrest;GO:0071277,cellular response to calcium ion;GO:0035690,cellular response to drug;GO:0071361,cellular response to ethanol;GO:0042149,cellular response to glucose starvation;GO:0071333,cellular response to glucose stimulus;GO:0070301,cellular response to hydrogen peroxide;GO:0071456,cellular response to hypoxia;GO:0031669,cellular response to nutrient levels;GO:0071417,cellular response to organonitrogen compound;GO:0034599,cellular response to oxidative stress;GO:0071380,cellular response to prostaglandin E stimulus;GO:0006695,cholesterol biosynthetic process;GO:0009631,cold acclimation;GO:0097009,energy homeostasis;GO:0006633,fatty acid biosynthetic process;GO:0055089,fatty acid homeostasis;GO:0019395,fatty acid oxidation;GO:0042593,glucose homeostasis;GO:0006006,glucose metabolic process;GO:0035556,intracellular signal transduction;GO:0008610,lipid biosynthetic process;GO:0016236,macroautophagy;GO:0061744,motor behavior;GO:0043066,negative regulation of apoptotic process;GO:0010629,negative regulation of gene expression;GO:0046318,negative regulation of glucosylceramide biosynthetic process;GO:0046627,negative regulation of insulin receptor signaling pathway;GO:0050995,negative regulation of lipid catabolic process;GO:0032007,negative regulation of TOR signaling;GO:1904428,negative regulation of tubulin deacetylation;GO:0070050,neuron cellular homeostasis;GO:0010508,positive regulation of autophagy;GO:0008284,positive regulation of cell population proliferation;GO:1903829,positive regulation of cellular protein localization;GO:0045542,positive regulation of cholesterol biosynthetic process;GO:0010628,positive regulation of gene expression;GO:0045821,positive regulation of glycolytic process;GO:1903109,positive regulation of mitochondrial transcription;GO:2000758,positive regulation of peptidyl-lysine acetylation;GO:1903955,positive regulation of protein targeting to mitochondrion;GO:0048643,positive regulation of skeletal muscle tissue development;GO:0006468,protein phosphorylation;GO:0120188,regulation of bile acid secretion;GO:0042752,regulation of circadian rhythm;GO:0016241,regulation of macroautophagy;GO:0070507,regulation of microtubule cytoskeleton organization;GO:0033135,regulation of peptidyl-serine phosphorylation;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0062028,regulation of stress granule assembly;GO:0060627,regulation of vesicle-mediated transport;GO:1904486,response to 17alpha-ethynylestradiol;GO:0014823,response to activity;GO:0031000,response to caffeine;GO:1901563,response to camptothecin;GO:0010332,response to gamma radiation;GO:0001666,response to hypoxia;GO:0009411,response to UV;GO:0048511,rhythmic process;GO:0007165,signal transduction;GO:0016055,Wnt signaling pathway	hsa:5562,path:hsa04371,Apelin signaling pathway;hsa:5562,path:hsa04068,FoxO signaling pathway;hsa:5562,path:hsa04151,PI3K-Akt signaling pathway;hsa:5562,path:hsa04152,AMPK signaling pathway;hsa:5562,path:hsa04150,mTOR signaling pathway;hsa:5562,path:hsa04140,Autophagy - animal;hsa:5562,path:hsa04530,Tight junction;hsa:5562,path:hsa04910,Insulin signaling pathway;hsa:5562,path:hsa04922,Glucagon signaling pathway;hsa:5562,path:hsa04920,Adipocytokine signaling pathway;hsa:5562,path:hsa04921,Oxytocin signaling pathway;hsa:5562,path:hsa04211,Longevity regulating pathway;hsa:5562,path:hsa04213,Longevity regulating pathway - multiple species;hsa:5562,path:hsa04710,Circadian rhythm;hsa:5562,path:hsa04714,Thermogenesis;hsa:5562,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:5562,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:5562,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:5562,path:hsa04931,Insulin resistance
MY18A_HUMAN	Q92614	MYO18A	Unconventional myosin-XVIIIa	0.669881355	0.599052436	1.136636911	0.915346904	0.6344668955	1.0259919075	0.6344668955	1.0259919075	0.618393664571862	0.333534	0	1.61709289291044	0.333796	0	GO:0042641,actomyosin;GO:0009986,cell surface;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0000139,Golgi membrane;GO:0016020,membrane;GO:0016459,myosin complex;GO:0005802,trans-Golgi network	GO:0051015,actin filament binding;GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0003677,DNA binding;GO:0003723,RNA binding;GO:0008094,ATPase activity, acting on DNA;GO:0003774,motor activity	GO:0031032,actomyosin structure organization;GO:0090164,asymmetric Golgi ribbon formation;GO:0016477,cell migration;GO:0006259,DNA metabolic process;GO:0007030,Golgi organization;GO:0090161,Golgi ribbon formation;GO:0048194,Golgi vesicle budding;GO:0043066,negative regulation of apoptotic process;GO:1903028,positive regulation of opsonization;GO:0050714,positive regulation of protein secretion;GO:0043030,regulation of macrophage activation	
ALG1_HUMAN	Q9BT22	ALG1	Chitobiosyldiphosphodolichol beta-mannosyltransferase	0.064637017	0.032053187	0.152165811	0.096961976	0.048345102	0.1245638935	0.048345102	0.1245638935	0.388114891415144	0.126715	0	2.57655663856082	0.127036	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0004578,chitobiosyldiphosphodolichol beta-mannosyltransferase activity;GO:0000030,mannosyltransferase activity	GO:0006488,dolichol-linked oligosaccharide biosynthetic process;GO:0006486,protein glycosylation	hsa:56052,path:hsa00510,N-Glycan biosynthesis;hsa:56052,path:hsa00513,Various types of N-glycan biosynthesis
PDIA5_HUMAN	Q14554	PDIA5	Protein disulfide-isomerase A5	1.673184444	1.191937356	3.068623356	1.821037477	1.4325609	2.4448304165	1.4325609	2.4448304165	0.585955119967316	0.304144	0	1.70661534633536	0.304429	0	GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane	GO:0016491,oxidoreductase activity;GO:0015037,peptide disulfide oxidoreductase activity;GO:0003756,protein disulfide isomerase activity	GO:0022900,electron transport chain;GO:0036498,IRE1-mediated unfolded protein response;GO:0006457,protein folding	
DOCK6_HUMAN	Q96HP0	DOCK6	Dedicator of cytokinesis protein 6	1.068091072	0.090892567	0.374795844	2.55E-05	0.5794918195	0.187410672	0.5794918195	0.187410672	3.09209616141817	0.131503	0	0.323405207275752	0.130944	0	GO:0005829,cytosol;GO:0048471,perinuclear region of cytoplasm	GO:0005085,guanyl-nucleotide exchange factor activity	GO:0007596,blood coagulation;GO:0007264,small GTPase mediated signal transduction	
EPIPL_HUMAN	P58107	EPPK1	Epiplakin	1.177431604	0.132975992	1.237622604	0.543830101	0.655203798	0.8907263525	0.655203798	0.8907263525	0.735583713405403	0.434483	0	1.3594645745628	0.434647	0	GO:0016327,apicolateral plasma membrane;GO:0016323,basolateral plasma membrane;GO:0005923,bicellular tight junction;GO:0030054,cell junction;GO:0071944,cell periphery;GO:0042995,cell projection;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0030056,hemidesmosome;GO:0045095,keratin filament;GO:0016020,membrane;GO:0097356,perinucleolar compartment;GO:0045111,intermediate filament cytoskeleton	GO:0019215,intermediate filament binding;GO:1990254,keratin filament binding;GO:0003723,RNA binding;GO:0005198,structural molecule activity	GO:0045110,intermediate filament bundle assembly;GO:0045104,intermediate filament cytoskeleton organization;GO:0045109,intermediate filament organization;GO:0030336,negative regulation of cell migration;GO:0050680,negative regulation of epithelial cell proliferation;GO:0051548,negative regulation of keratinocyte migration;GO:0010839,negative regulation of keratinocyte proliferation;GO:0061045,negative regulation of wound healing;GO:1905041,regulation of epithelium regeneration;GO:0042060,wound healing	
P5CR2_HUMAN	Q96C36	PYCR2	Pyrroline-5-carboxylate reductase 2	1.340244768	0.058606174	0.516615826	0.593756415	0.699425471	0.5551861205	0.699425471	0.5551861205	1.25980359590059	0.358484	0	0.793774524262357	0.358135	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0004735,pyrroline-5-carboxylate reductase activity	GO:0034599,cellular response to oxidative stress;GO:0009064,glutamine family amino acid metabolic process;GO:0055129,L-proline biosynthetic process;GO:0006561,proline biosynthetic process;GO:0008652,cellular amino acid biosynthetic process	hsa:29920,path:hsa00330,Arginine and proline metabolism
CHCH9_HUMAN	Q5T1J5	CHCHD2P9	Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial	0.367328051	0.72316625	0.0234537	2.55E-05	0.5452471505	0.0117396	0.5452471505	0.0117396	46.4451216821698	0.000333	1	0.0215307865235694	0.000324	-1	GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0043565,sequence-specific DNA binding	GO:0007005,mitochondrion organization;GO:0045944,positive regulation of transcription by RNA polymerase II	
IGHG1_HUMAN	P01857	IGHG1	Immunoglobulin heavy constant gamma 1	130.3192782	154.7581249	185.4154193	445.5445728	142.53870155	315.47999605	142.53870155	315.47999605	0.451815339592591	0.181462	0	2.21329360110198	0.181797	0	GO:0072562,blood microparticle;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0042571,immunoglobulin complex, circulating;GO:0016021,integral component of membrane	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0019221,cytokine-mediated signaling pathway;GO:0042742,defense response to bacterium;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0045087,innate immune response;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0030449,regulation of complement activation	
XRN1_HUMAN	Q8IZH2	XRN1	5'-3' exoribonuclease 1	0.084327794	0.047581634	0.105945188	0.039525464	0.065954714	0.072735326	0.065954714	0.072735326	0.906776907826054	0.465985	0	1.10280708669285	0.465859	0	GO:0005829,cytosol;GO:0030425,dendrite;GO:0016020,membrane;GO:0043025,neuronal cell body;GO:0005634,nucleus;GO:0000932,P-body;GO:0005886,plasma membrane;GO:0045202,synapse	GO:0004534,5'-3' exoribonuclease activity;GO:0051880,G-quadruplex DNA binding;GO:0002151,G-quadruplex RNA binding;GO:0003723,RNA binding;GO:0070034,telomerase RNA binding;GO:0008409,5'-3' exonuclease activity;GO:0003676,nucleic acid binding	GO:0071409,cellular response to cycloheximide;GO:1905795,cellular response to puromycin;GO:0071044,histone mRNA catabolic process;GO:0032211,negative regulation of telomere maintenance via telomerase;GO:0017148,negative regulation of translation;GO:0071028,nuclear mRNA surveillance;GO:0000956,nuclear-transcribed mRNA catabolic process;GO:0043488,regulation of mRNA stability;GO:0033574,response to testosterone;GO:0090503,RNA phosphodiester bond hydrolysis, exonucleolytic;GO:0016075,rRNA catabolic process	hsa:54464,path:hsa03008,Ribosome biogenesis in eukaryotes;hsa:54464,path:hsa03018,RNA degradation
EIF2A_HUMAN	Q9BY44	EIF2A	Eukaryotic translation initiation factor 2A	4.212579269	3.085014191	3.782149274	2.413749896	3.64879673	3.097949585	3.64879673	3.097949585	1.17781023541092	0.379883	0	0.84903320580426	0.379575	0	GO:0072562,blood microparticle;GO:0005737,cytoplasm;GO:0022627,cytosolic small ribosomal subunit;GO:0005850,eukaryotic translation initiation factor 2 complex;GO:0005615,extracellular space	GO:0045296,cadherin binding;GO:0003729,mRNA binding;GO:0043022,ribosome binding;GO:0003743,translation initiation factor activity;GO:0000049,tRNA binding	GO:0009967,positive regulation of signal transduction;GO:0006468,protein phosphorylation;GO:0006417,regulation of translation;GO:1990928,response to amino acid starvation;GO:0042255,ribosome assembly;GO:0032933,SREBP signaling pathway	
MEP50_HUMAN	Q9BQA1	WDR77	Methylosome protein 50	0.272369502	0.108673127	0.3587674	0.32028454	0.1905213145	0.33952597	0.1905213145	0.33952597	0.561139150857886	0.281412	0	1.7820891635723	0.281713	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0034709,methylosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0045495,pole plasm	GO:0008327,methyl-CpG binding;GO:0030374,nuclear receptor coactivator activity	GO:0060770,negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0007315,pole plasm assembly;GO:0008284,positive regulation of cell population proliferation;GO:0006357,regulation of transcription by RNA polymerase II;GO:0060528,secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;GO:0000387,spliceosomal snRNP assembly	
CARM1_HUMAN	Q86X55	CARM1	Histone-arginine methyltransferase CARM1	0.369895897	0.494245474	0.534186584	0.601662643	0.4320706855	0.5679246135	0.4320706855	0.5679246135	0.760788800536816	0.454824	0	1.31442523771958	0.454966	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0008013,beta-catenin binding;GO:0042054,histone methyltransferase activity;GO:0035642,histone methyltransferase activity (H3-R17 specific);GO:0008469,histone-arginine N-methyltransferase activity;GO:0070577,lysine-acetylated histone binding;GO:0030374,nuclear receptor coactivator activity;GO:0008276,protein methyltransferase activity;GO:0016274,protein-arginine N-methyltransferase activity;GO:0035242,protein-arginine omega-N asymmetric methyltransferase activity;GO:0003713,transcription coactivator activity;GO:0000976,transcription regulatory region sequence-specific DNA binding	GO:0007568,aging;GO:0006977,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0034971,histone H3-R17 methylation;GO:0034970,histone H3-R2 methylation;GO:0016571,histone methylation;GO:2000171,negative regulation of dendrite development;GO:0008284,positive regulation of cell population proliferation;GO:0045600,positive regulation of fat cell differentiation;GO:0033146,regulation of intracellular estrogen receptor signaling pathway;GO:0019216,regulation of lipid metabolic process;GO:1902415,regulation of mRNA binding;GO:0006355,regulation of transcription, DNA-templated;GO:0051591,response to cAMP;GO:0016032,viral process;GO:0006325,chromatin organization	hsa:10498,path:hsa01522,Endocrine resistance
PSB5_HUMAN	P28074	PSMB5	Proteasome subunit beta type-5	4.655776133	5.047899438	0.634427199	0.030905947	4.8518377855	0.332666573	4.8518377855	0.332666573	14.5846868284539	0.007618	1	0.0685650649727395	0.007503	-1	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000502,proteasome complex;GO:0005839,proteasome core complex;GO:0019774,proteasome core complex, beta-subunit complex	GO:0004175,endopeptidase activity;GO:0008233,peptidase activity;GO:0004298,threonine-type endopeptidase activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006508,proteolysis;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0006979,response to oxidative stress;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5693,path:hsa03050,Proteasome
PGFRB_HUMAN	P09619	PDGFRB	Platelet-derived growth factor receptor beta	0.123319498	0.259078776	0.257502586	0.907418324	0.191199137	0.582460455	0.191199137	0.582460455	0.328261146930567	0.081054	0	3.04635504186402	0.081329	0	GO:0016324,apical plasma membrane;GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0031226,intrinsic component of plasma membrane;GO:0043202,lysosomal lumen;GO:0016020,membrane;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0043235,receptor complex	GO:0005524,ATP binding;GO:0019899,enzyme binding;GO:0019838,growth factor binding;GO:0043548,phosphatidylinositol 3-kinase binding;GO:0004992,platelet activating factor receptor activity;GO:0005019,platelet-derived growth factor beta-receptor activity;GO:0048407,platelet-derived growth factor binding;GO:0005161,platelet-derived growth factor receptor binding;GO:0005017,platelet-derived growth factor-activated receptor activity;GO:0019901,protein kinase binding;GO:0004713,protein tyrosine kinase activity;GO:0005102,signaling receptor binding;GO:0004714,transmembrane receptor protein tyrosine kinase activity;GO:0038085,vascular endothelial growth factor binding	GO:0007568,aging;GO:0035909,aorta morphogenesis;GO:0055003,cardiac myofibril assembly;GO:0060326,cell chemotaxis;GO:0016477,cell migration;GO:0060981,cell migration involved in coronary angiogenesis;GO:0035441,cell migration involved in vasculogenesis;GO:0006024,glycosaminoglycan biosynthetic process;GO:0048839,inner ear development;GO:0060437,lung growth;GO:0008584,male gonad development;GO:0000165,MAPK cascade;GO:0072278,metanephric comma-shaped body morphogenesis;GO:0072277,metanephric glomerular capillary formation;GO:0072262,metanephric glomerular mesangial cell proliferation involved in metanephros development;GO:0035789,metanephric mesenchymal cell migration;GO:0072075,metanephric mesenchyme development;GO:0072284,metanephric S-shaped body morphogenesis;GO:0007275,multicellular organism development;GO:0043066,negative regulation of apoptotic process;GO:0018108,peptidyl-tyrosine phosphorylation;GO:0046488,phosphatidylinositol metabolic process;GO:0048015,phosphatidylinositol-mediated signaling;GO:0048008,platelet-derived growth factor receptor signaling pathway;GO:0035791,platelet-derived growth factor receptor-beta signaling pathway;GO:0043065,positive regulation of apoptotic process;GO:0090280,positive regulation of calcium ion import;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0038091,positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway;GO:0050921,positive regulation of chemotaxis;GO:0032967,positive regulation of collagen biosynthetic process;GO:2000573,positive regulation of DNA biosynthetic process;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0048146,positive regulation of fibroblast proliferation;GO:2000491,positive regulation of hepatic stellate cell activation;GO:0033674,positive regulation of kinase activity;GO:0043406,positive regulation of MAP kinase activity;GO:0035793,positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway;GO:0045840,positive regulation of mitotic nuclear division;GO:0043552,positive regulation of phosphatidylinositol 3-kinase activity;GO:0014068,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0010863,positive regulation of phospholipase C activity;GO:0032516,positive regulation of phosphoprotein phosphatase activity;GO:0051897,positive regulation of protein kinase B signaling;GO:2000379,positive regulation of reactive oxygen species metabolic process;GO:0035025,positive regulation of Rho protein signal transduction;GO:0014911,positive regulation of smooth muscle cell migration;GO:0048661,positive regulation of smooth muscle cell proliferation;GO:0046777,protein autophosphorylation;GO:0032956,regulation of actin cytoskeleton organization;GO:0032355,response to estradiol;GO:0043627,response to estrogen;GO:0034405,response to fluid shear stress;GO:0042542,response to hydrogen peroxide;GO:0055093,response to hyperoxia;GO:0032526,response to retinoic acid;GO:0009636,response to toxic substance;GO:0061298,retina vasculature development in camera-type eye;GO:0007165,signal transduction;GO:0071670,smooth muscle cell chemotaxis;GO:0007169,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0042060,wound healing	hsa:5159,path:hsa04014,Ras signaling pathway;hsa:5159,path:hsa04015,Rap1 signaling pathway;hsa:5159,path:hsa04010,MAPK signaling pathway;hsa:5159,path:hsa04630,Jak-STAT signaling pathway;hsa:5159,path:hsa04020,Calcium signaling pathway;hsa:5159,path:hsa04072,Phospholipase D signaling pathway;hsa:5159,path:hsa04151,PI3K-Akt signaling pathway;hsa:5159,path:hsa04510,Focal adhesion;hsa:5159,path:hsa04540,Gap junction;hsa:5159,path:hsa04810,Regulation of actin cytoskeleton;hsa:5159,path:hsa05200,Pathways in cancer;hsa:5159,path:hsa05206,MicroRNAs in cancer;hsa:5159,path:hsa05230,Central carbon metabolism in cancer;hsa:5159,path:hsa05231,Choline metabolism in cancer;hsa:5159,path:hsa05214,Glioma;hsa:5159,path:hsa05218,Melanoma;hsa:5159,path:hsa05215,Prostate cancer;hsa:5159,path:hsa05165,Human papillomavirus infection;hsa:5159,path:hsa01521,EGFR tyrosine kinase inhibitor resistance
HLAB_HUMAN	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.762853917	0.577166044	1.275910902	1.197570045	0.6700099805	1.2367404735	0.6700099805	1.2367404735	0.541754713180736	0.263570	0	1.84585380739713	0.263882	0	GO:0009986,cell surface;GO:0031901,early endosome membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0000139,Golgi membrane;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0042612,MHC class I protein complex;GO:0032398,MHC class Ib protein complex;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0030667,secretory granule membrane;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0030666,endocytic vesicle membrane;GO:0001772,immunological synapse;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0042613,MHC class II protein complex;GO:0032588,trans-Golgi network membrane;GO:0030658,transport vesicle membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0010008,endosome membrane;GO:0005882,intermediate filament;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0005797,Golgi medial cisterna;GO:0042824,MHC class I peptide loading complex;GO:0035577,azurophil granule membrane;GO:0033106,cis-Golgi network membrane;GO:0005769,early endosome;GO:0031527,filopodium membrane;GO:0005771,multivesicular body	GO:0030881,beta-2-microglobulin binding;GO:0042288,MHC class I protein binding;GO:0046703,natural killer cell lectin-like receptor binding;GO:0042605,peptide antigen binding;GO:0005102,signaling receptor binding;GO:0042608,T cell receptor binding;GO:0051087,chaperone binding;GO:0046977,TAP binding;GO:0023026,MHC class II protein complex binding;GO:0032395,MHC class II receptor activity;GO:0030247,polysaccharide binding;GO:0042609,CD4 receptor binding;GO:0005200,structural constituent of cytoskeleton;GO:0042610,CD8 receptor binding;GO:0003723,RNA binding;GO:0062061,TAP complex binding;GO:0071889,14-3-3 protein binding;GO:0046978,TAP1 binding;GO:0046979,TAP2 binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:1990405,protein antigen binding;GO:0015643,toxic substance binding;GO:0008134,transcription factor binding;GO:0031625,ubiquitin protein ligase binding;GO:0046872,metal ion binding	GO:0002250,adaptive immune response;GO:0019731,antibacterial humoral response;GO:0002476,antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0002477,antigen processing and presentation of exogenous peptide antigen via MHC class Ib;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0036037,CD8-positive, alpha-beta T cell activation;GO:0050830,defense response to Gram-positive bacterium;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0002519,natural killer cell tolerance induction;GO:0045953,negative regulation of natural killer cell mediated cytotoxicity;GO:0001815,positive regulation of antibody-dependent cellular cytotoxicity;GO:2001187,positive regulation of CD8-positive, alpha-beta T cell activation;GO:2000566,positive regulation of CD8-positive, alpha-beta T cell proliferation;GO:0002639,positive regulation of immunoglobulin production;GO:0032736,positive regulation of interleukin-13 production;GO:0032753,positive regulation of interleukin-4 production;GO:0002729,positive regulation of natural killer cell cytokine production;GO:0045954,positive regulation of natural killer cell mediated cytotoxicity;GO:0002717,positive regulation of natural killer cell mediated immunity;GO:0032819,positive regulation of natural killer cell proliferation;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:0032759,positive regulation of TRAIL production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0042270,protection from natural killer cell mediated cytotoxicity;GO:0050776,regulation of immune response;GO:0002715,regulation of natural killer cell mediated immunity;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process;GO:0002486,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006952,defense response;GO:0016045,detection of bacterium;GO:0006955,immune response;GO:0043312,neutrophil degranulation;GO:2001198,regulation of dendritic cell differentiation;GO:0032655,regulation of interleukin-12 production;GO:0032675,regulation of interleukin-6 production;GO:0002667,regulation of T cell anergy;GO:0002491,antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002504,antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0050890,cognition;GO:0002469,myeloid dendritic cell antigen processing and presentation;GO:0002503,peptide antigen assembly with MHC class II protein complex;GO:2000516,positive regulation of CD4-positive, alpha-beta T cell activation;GO:0032831,positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0043382,positive regulation of memory T cell differentiation;GO:0045622,regulation of T-helper cell differentiation;GO:0050852,T cell receptor signaling pathway;GO:0002399,MHC class II protein complex assembly;GO:2001190,positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0042102,positive regulation of T cell proliferation;GO:0032729,positive regulation of interferon-gamma production;GO:0050870,positive regulation of T cell activation;GO:0008544,epidermis development;GO:0006959,humoral immune response;GO:0002437,inflammatory response to antigenic stimulus;GO:0030225,macrophage differentiation;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0032689,negative regulation of interferon-gamma production;GO:0042130,negative regulation of T cell proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0033674,positive regulation of kinase activity;GO:0043410,positive regulation of MAPK cascade;GO:0045657,positive regulation of monocyte differentiation;GO:0001934,positive regulation of protein phosphorylation;GO:0002842,positive regulation of T cell mediated immune response to tumor cell;GO:0045893,positive regulation of transcription, DNA-templated;GO:0046598,positive regulation of viral entry into host cell;GO:0051262,protein tetramerization;GO:0032653,regulation of interleukin-10 production;GO:0032673,regulation of interleukin-4 production;GO:0007165,signal transduction;GO:0042088,T-helper 1 type immune response;GO:0002587,negative regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0045580,regulation of T cell differentiation;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002485,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent;GO:0042590,antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:2000568,positive regulation of memory T cell activation;GO:0002726,positive regulation of T cell cytokine production;GO:0016567,protein ubiquitination;GO:0001913,T cell mediated cytotoxicity;GO:0002419,T cell mediated cytotoxicity directed against tumor cell target;GO:0002728,negative regulation of natural killer cell cytokine production;GO:0043322,negative regulation of natural killer cell degranulation;GO:1901215,negative regulation of neuron death;GO:0002725,negative regulation of T cell cytokine production;GO:0043323,positive regulation of natural killer cell degranulation;GO:0071346,cellular response to interferon-gamma;GO:0006968,cellular defense response;GO:0002767,immune response-inhibiting cell surface receptor signaling pathway;GO:0016525,negative regulation of angiogenesis;GO:2001199,negative regulation of dendritic cell differentiation;GO:0070317,negative regulation of G0 to G1 transition;GO:0050777,negative regulation of immune response;GO:0051898,negative regulation of protein kinase B signaling;GO:0001915,negative regulation of T cell mediated cytotoxicity;GO:0002451,peripheral B cell tolerance induction;GO:2000774,positive regulation of cellular senescence;GO:2000353,positive regulation of endothelial cell apoptotic process;GO:0032735,positive regulation of interleukin-12 production;GO:0060907,positive regulation of macrophage cytokine production;GO:0045591,positive regulation of regulatory T cell differentiation;GO:0002666,positive regulation of T cell tolerance induction;GO:0002645,positive regulation of tolerance induction;GO:0070207,protein homotrimerization;GO:0019882,antigen processing and presentation;GO:0002344,B cell affinity maturation;GO:0046635,positive regulation of alpha-beta T cell activation;GO:0002579,positive regulation of antigen processing and presentation;GO:0002827,positive regulation of T-helper 1 type immune response	hsa:3133,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3133,path:hsa04144,Endocytosis;hsa:3133,path:hsa04145,Phagosome;hsa:3133,path:hsa04218,Cellular senescence;hsa:3133,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3133,path:hsa04612,Antigen processing and presentation;hsa:3133,path:hsa05203,Viral carcinogenesis;hsa:3133,path:hsa05320,Autoimmune thyroid disease;hsa:3133,path:hsa05330,Allograft rejection;hsa:3133,path:hsa05332,Graft-versus-host disease;hsa:3133,path:hsa05416,Viral myocarditis;hsa:3133,path:hsa04940,Type I diabetes mellitus;hsa:3133,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3133,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3133,path:hsa05168,Herpes simplex virus 1 infection;hsa:3133,path:hsa05163,Human cytomegalovirus infection;hsa:3133,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3133,path:hsa05169,Epstein-Barr virus infection;hsa:3133,path:hsa05165,Human papillomavirus infection;hsa:3106,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3106,path:hsa04144,Endocytosis;hsa:3106,path:hsa04145,Phagosome;hsa:3106,path:hsa04218,Cellular senescence;hsa:3106,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3106,path:hsa04612,Antigen processing and presentation;hsa:3106,path:hsa05203,Viral carcinogenesis;hsa:3106,path:hsa05320,Autoimmune thyroid disease;hsa:3106,path:hsa05330,Allograft rejection;hsa:3106,path:hsa05332,Graft-versus-host disease;hsa:3106,path:hsa05416,Viral myocarditis;hsa:3106,path:hsa04940,Type I diabetes mellitus;hsa:3106,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3106,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3106,path:hsa05168,Herpes simplex virus 1 infection;hsa:3106,path:hsa05163,Human cytomegalovirus infection;hsa:3106,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3106,path:hsa05169,Epstein-Barr virus infection;hsa:3106,path:hsa05165,Human papillomavirus infection;hsa:3122,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3122,path:hsa04145,Phagosome;hsa:3122,path:hsa04640,Hematopoietic cell lineage;hsa:3122,path:hsa04612,Antigen processing and presentation;hsa:3122,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3122,path:hsa04659,Th17 cell differentiation;hsa:3122,path:hsa04672,Intestinal immune network for IgA production;hsa:3122,path:hsa05310,Asthma;hsa:3122,path:hsa05322,Systemic lupus erythematosus;hsa:3122,path:hsa05323,Rheumatoid arthritis;hsa:3122,path:hsa05320,Autoimmune thyroid disease;hsa:3122,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3122,path:hsa05330,Allograft rejection;hsa:3122,path:hsa05332,Graft-versus-host disease;hsa:3122,path:hsa05416,Viral myocarditis;hsa:3122,path:hsa04940,Type I diabetes mellitus;hsa:3122,path:hsa05150,Staphylococcus aureus infection;hsa:3122,path:hsa05152,Tuberculosis;hsa:3122,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3122,path:hsa05164,Influenza A;hsa:3122,path:hsa05168,Herpes simplex virus 1 infection;hsa:3122,path:hsa05169,Epstein-Barr virus infection;hsa:3122,path:hsa05145,Toxoplasmosis;hsa:3122,path:hsa05140,Leishmaniasis;hsa:3109,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3109,path:hsa04145,Phagosome;hsa:3109,path:hsa04640,Hematopoietic cell lineage;hsa:3109,path:hsa04612,Antigen processing and presentation;hsa:3109,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3109,path:hsa04659,Th17 cell differentiation;hsa:3109,path:hsa04672,Intestinal immune network for IgA production;hsa:3109,path:hsa05310,Asthma;hsa:3109,path:hsa05322,Systemic lupus erythematosus;hsa:3109,path:hsa05323,Rheumatoid arthritis;hsa:3109,path:hsa05320,Autoimmune thyroid disease;hsa:3109,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3109,path:hsa05330,Allograft rejection;hsa:3109,path:hsa05332,Graft-versus-host disease;hsa:3109,path:hsa05416,Viral myocarditis;hsa:3109,path:hsa04940,Type I diabetes mellitus;hsa:3109,path:hsa05150,Staphylococcus aureus infection;hsa:3109,path:hsa05152,Tuberculosis;hsa:3109,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3109,path:hsa05164,Influenza A;hsa:3109,path:hsa05168,Herpes simplex virus 1 infection;hsa:3109,path:hsa05169,Epstein-Barr virus infection;hsa:3109,path:hsa05145,Toxoplasmosis;hsa:3109,path:hsa05140,Leishmaniasis;hsa:3115,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3115,path:hsa04145,Phagosome;hsa:3115,path:hsa04640,Hematopoietic cell lineage;hsa:3115,path:hsa04612,Antigen processing and presentation;hsa:3115,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3115,path:hsa04659,Th17 cell differentiation;hsa:3115,path:hsa04672,Intestinal immune network for IgA production;hsa:3115,path:hsa05310,Asthma;hsa:3115,path:hsa05322,Systemic lupus erythematosus;hsa:3115,path:hsa05323,Rheumatoid arthritis;hsa:3115,path:hsa05320,Autoimmune thyroid disease;hsa:3115,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3115,path:hsa05330,Allograft rejection;hsa:3115,path:hsa05332,Graft-versus-host disease;hsa:3115,path:hsa05416,Viral myocarditis;hsa:3115,path:hsa04940,Type I diabetes mellitus;hsa:3115,path:hsa05150,Staphylococcus aureus infection;hsa:3115,path:hsa05152,Tuberculosis;hsa:3115,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3115,path:hsa05164,Influenza A;hsa:3115,path:hsa05168,Herpes simplex virus 1 infection;hsa:3115,path:hsa05169,Epstein-Barr virus infection;hsa:3115,path:hsa05145,Toxoplasmosis;hsa:3115,path:hsa05140,Leishmaniasis;hsa:3123,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3123,path:hsa04145,Phagosome;hsa:3123,path:hsa04640,Hematopoietic cell lineage;hsa:3123,path:hsa04612,Antigen processing and presentation;hsa:3123,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3123,path:hsa04659,Th17 cell differentiation;hsa:3123,path:hsa04672,Intestinal immune network for IgA production;hsa:3123,path:hsa05310,Asthma;hsa:3123,path:hsa05322,Systemic lupus erythematosus;hsa:3123,path:hsa05323,Rheumatoid arthritis;hsa:3123,path:hsa05320,Autoimmune thyroid disease;hsa:3123,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3123,path:hsa05330,Allograft rejection;hsa:3123,path:hsa05332,Graft-versus-host disease;hsa:3123,path:hsa05416,Viral myocarditis;hsa:3123,path:hsa04940,Type I diabetes mellitus;hsa:3123,path:hsa05150,Staphylococcus aureus infection;hsa:3123,path:hsa05152,Tuberculosis;hsa:3123,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3123,path:hsa05164,Influenza A;hsa:3123,path:hsa05168,Herpes simplex virus 1 infection;hsa:3123,path:hsa05169,Epstein-Barr virus infection;hsa:3123,path:hsa05145,Toxoplasmosis;hsa:3123,path:hsa05140,Leishmaniasis;hsa:3111,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3111,path:hsa04145,Phagosome;hsa:3111,path:hsa04640,Hematopoietic cell lineage;hsa:3111,path:hsa04612,Antigen processing and presentation;hsa:3111,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3111,path:hsa04659,Th17 cell differentiation;hsa:3111,path:hsa04672,Intestinal immune network for IgA production;hsa:3111,path:hsa05310,Asthma;hsa:3111,path:hsa05322,Systemic lupus erythematosus;hsa:3111,path:hsa05323,Rheumatoid arthritis;hsa:3111,path:hsa05320,Autoimmune thyroid disease;hsa:3111,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3111,path:hsa05330,Allograft rejection;hsa:3111,path:hsa05332,Graft-versus-host disease;hsa:3111,path:hsa05416,Viral myocarditis;hsa:3111,path:hsa04940,Type I diabetes mellitus;hsa:3111,path:hsa05150,Staphylococcus aureus infection;hsa:3111,path:hsa05152,Tuberculosis;hsa:3111,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3111,path:hsa05164,Influenza A;hsa:3111,path:hsa05168,Herpes simplex virus 1 infection;hsa:3111,path:hsa05169,Epstein-Barr virus infection;hsa:3111,path:hsa05145,Toxoplasmosis;hsa:3111,path:hsa05140,Leishmaniasis;hsa:3112,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3112,path:hsa04145,Phagosome;hsa:3112,path:hsa04640,Hematopoietic cell lineage;hsa:3112,path:hsa04612,Antigen processing and presentation;hsa:3112,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3112,path:hsa04659,Th17 cell differentiation;hsa:3112,path:hsa04672,Intestinal immune network for IgA production;hsa:3112,path:hsa05310,Asthma;hsa:3112,path:hsa05322,Systemic lupus erythematosus;hsa:3112,path:hsa05323,Rheumatoid arthritis;hsa:3112,path:hsa05320,Autoimmune thyroid disease;hsa:3112,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3112,path:hsa05330,Allograft rejection;hsa:3112,path:hsa05332,Graft-versus-host disease;hsa:3112,path:hsa05416,Viral myocarditis;hsa:3112,path:hsa04940,Type I diabetes mellitus;hsa:3112,path:hsa05150,Staphylococcus aureus infection;hsa:3112,path:hsa05152,Tuberculosis;hsa:3112,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3112,path:hsa05164,Influenza A;hsa:3112,path:hsa05168,Herpes simplex virus 1 infection;hsa:3112,path:hsa05169,Epstein-Barr virus infection;hsa:3112,path:hsa05145,Toxoplasmosis;hsa:3112,path:hsa05140,Leishmaniasis;hsa:3105,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3105,path:hsa04144,Endocytosis;hsa:3105,path:hsa04145,Phagosome;hsa:3105,path:hsa04218,Cellular senescence;hsa:3105,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3105,path:hsa04612,Antigen processing and presentation;hsa:3105,path:hsa05203,Viral carcinogenesis;hsa:3105,path:hsa05320,Autoimmune thyroid disease;hsa:3105,path:hsa05330,Allograft rejection;hsa:3105,path:hsa05332,Graft-versus-host disease;hsa:3105,path:hsa05416,Viral myocarditis;hsa:3105,path:hsa04940,Type I diabetes mellitus;hsa:3105,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3105,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3105,path:hsa05168,Herpes simplex virus 1 infection;hsa:3105,path:hsa05163,Human cytomegalovirus infection;hsa:3105,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3105,path:hsa05169,Epstein-Barr virus infection;hsa:3105,path:hsa05165,Human papillomavirus infection;hsa:3134,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3134,path:hsa04144,Endocytosis;hsa:3134,path:hsa04145,Phagosome;hsa:3134,path:hsa04218,Cellular senescence;hsa:3134,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3134,path:hsa04612,Antigen processing and presentation;hsa:3134,path:hsa05203,Viral carcinogenesis;hsa:3134,path:hsa05320,Autoimmune thyroid disease;hsa:3134,path:hsa05330,Allograft rejection;hsa:3134,path:hsa05332,Graft-versus-host disease;hsa:3134,path:hsa05416,Viral myocarditis;hsa:3134,path:hsa04940,Type I diabetes mellitus;hsa:3134,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3134,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3134,path:hsa05168,Herpes simplex virus 1 infection;hsa:3134,path:hsa05163,Human cytomegalovirus infection;hsa:3134,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3134,path:hsa05169,Epstein-Barr virus infection;hsa:3134,path:hsa05165,Human papillomavirus infection;hsa:3119,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3119,path:hsa04145,Phagosome;hsa:3119,path:hsa04640,Hematopoietic cell lineage;hsa:3119,path:hsa04612,Antigen processing and presentation;hsa:3119,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3119,path:hsa04659,Th17 cell differentiation;hsa:3119,path:hsa04672,Intestinal immune network for IgA production;hsa:3119,path:hsa05310,Asthma;hsa:3119,path:hsa05322,Systemic lupus erythematosus;hsa:3119,path:hsa05323,Rheumatoid arthritis;hsa:3119,path:hsa05320,Autoimmune thyroid disease;hsa:3119,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3119,path:hsa05330,Allograft rejection;hsa:3119,path:hsa05332,Graft-versus-host disease;hsa:3119,path:hsa05416,Viral myocarditis;hsa:3119,path:hsa04940,Type I diabetes mellitus;hsa:3119,path:hsa05150,Staphylococcus aureus infection;hsa:3119,path:hsa05152,Tuberculosis;hsa:3119,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3119,path:hsa05164,Influenza A;hsa:3119,path:hsa05168,Herpes simplex virus 1 infection;hsa:3119,path:hsa05169,Epstein-Barr virus infection;hsa:3119,path:hsa05145,Toxoplasmosis;hsa:3119,path:hsa05140,Leishmaniasis;hsa:3113,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3113,path:hsa04145,Phagosome;hsa:3113,path:hsa04640,Hematopoietic cell lineage;hsa:3113,path:hsa04612,Antigen processing and presentation;hsa:3113,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3113,path:hsa04659,Th17 cell differentiation;hsa:3113,path:hsa04672,Intestinal immune network for IgA production;hsa:3113,path:hsa05310,Asthma;hsa:3113,path:hsa05322,Systemic lupus erythematosus;hsa:3113,path:hsa05323,Rheumatoid arthritis;hsa:3113,path:hsa05320,Autoimmune thyroid disease;hsa:3113,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3113,path:hsa05330,Allograft rejection;hsa:3113,path:hsa05332,Graft-versus-host disease;hsa:3113,path:hsa05416,Viral myocarditis;hsa:3113,path:hsa04940,Type I diabetes mellitus;hsa:3113,path:hsa05150,Staphylococcus aureus infection;hsa:3113,path:hsa05152,Tuberculosis;hsa:3113,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3113,path:hsa05164,Influenza A;hsa:3113,path:hsa05168,Herpes simplex virus 1 infection;hsa:3113,path:hsa05169,Epstein-Barr virus infection;hsa:3113,path:hsa05145,Toxoplasmosis;hsa:3113,path:hsa05140,Leishmaniasis;hsa:3125,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3125,path:hsa04145,Phagosome;hsa:3125,path:hsa04640,Hematopoietic cell lineage;hsa:3125,path:hsa04612,Antigen processing and presentation;hsa:3125,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3125,path:hsa04659,Th17 cell differentiation;hsa:3125,path:hsa04672,Intestinal immune network for IgA production;hsa:3125,path:hsa05310,Asthma;hsa:3125,path:hsa05322,Systemic lupus erythematosus;hsa:3125,path:hsa05323,Rheumatoid arthritis;hsa:3125,path:hsa05320,Autoimmune thyroid disease;hsa:3125,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3125,path:hsa05330,Allograft rejection;hsa:3125,path:hsa05332,Graft-versus-host disease;hsa:3125,path:hsa05416,Viral myocarditis;hsa:3125,path:hsa04940,Type I diabetes mellitus;hsa:3125,path:hsa05150,Staphylococcus aureus infection;hsa:3125,path:hsa05152,Tuberculosis;hsa:3125,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3125,path:hsa05164,Influenza A;hsa:3125,path:hsa05168,Herpes simplex virus 1 infection;hsa:3125,path:hsa05169,Epstein-Barr virus infection;hsa:3125,path:hsa05145,Toxoplasmosis;hsa:3125,path:hsa05140,Leishmaniasis;hsa:3126,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3126,path:hsa04145,Phagosome;hsa:3126,path:hsa04640,Hematopoietic cell lineage;hsa:3126,path:hsa04612,Antigen processing and presentation;hsa:3126,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3126,path:hsa04659,Th17 cell differentiation;hsa:3126,path:hsa04672,Intestinal immune network for IgA production;hsa:3126,path:hsa05310,Asthma;hsa:3126,path:hsa05322,Systemic lupus erythematosus;hsa:3126,path:hsa05323,Rheumatoid arthritis;hsa:3126,path:hsa05320,Autoimmune thyroid disease;hsa:3126,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3126,path:hsa05330,Allograft rejection;hsa:3126,path:hsa05332,Graft-versus-host disease;hsa:3126,path:hsa05416,Viral myocarditis;hsa:3126,path:hsa04940,Type I diabetes mellitus;hsa:3126,path:hsa05150,Staphylococcus aureus infection;hsa:3126,path:hsa05152,Tuberculosis;hsa:3126,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3126,path:hsa05164,Influenza A;hsa:3126,path:hsa05168,Herpes simplex virus 1 infection;hsa:3126,path:hsa05169,Epstein-Barr virus infection;hsa:3126,path:hsa05145,Toxoplasmosis;hsa:3126,path:hsa05140,Leishmaniasis;hsa:3107,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3107,path:hsa04144,Endocytosis;hsa:3107,path:hsa04145,Phagosome;hsa:3107,path:hsa04218,Cellular senescence;hsa:3107,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3107,path:hsa04612,Antigen processing and presentation;hsa:3107,path:hsa05203,Viral carcinogenesis;hsa:3107,path:hsa05320,Autoimmune thyroid disease;hsa:3107,path:hsa05330,Allograft rejection;hsa:3107,path:hsa05332,Graft-versus-host disease;hsa:3107,path:hsa05416,Viral myocarditis;hsa:3107,path:hsa04940,Type I diabetes mellitus;hsa:3107,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3107,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3107,path:hsa05168,Herpes simplex virus 1 infection;hsa:3107,path:hsa05163,Human cytomegalovirus infection;hsa:3107,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3107,path:hsa05169,Epstein-Barr virus infection;hsa:3107,path:hsa05165,Human papillomavirus infection;hsa:3135,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3135,path:hsa04144,Endocytosis;hsa:3135,path:hsa04145,Phagosome;hsa:3135,path:hsa04218,Cellular senescence;hsa:3135,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3135,path:hsa04612,Antigen processing and presentation;hsa:3135,path:hsa05203,Viral carcinogenesis;hsa:3135,path:hsa05320,Autoimmune thyroid disease;hsa:3135,path:hsa05330,Allograft rejection;hsa:3135,path:hsa05332,Graft-versus-host disease;hsa:3135,path:hsa05416,Viral myocarditis;hsa:3135,path:hsa04940,Type I diabetes mellitus;hsa:3135,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3135,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3135,path:hsa05168,Herpes simplex virus 1 infection;hsa:3135,path:hsa05163,Human cytomegalovirus infection;hsa:3135,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3135,path:hsa05169,Epstein-Barr virus infection;hsa:3135,path:hsa05165,Human papillomavirus infection;hsa:3127,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3127,path:hsa04145,Phagosome;hsa:3127,path:hsa04640,Hematopoietic cell lineage;hsa:3127,path:hsa04612,Antigen processing and presentation;hsa:3127,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3127,path:hsa04659,Th17 cell differentiation;hsa:3127,path:hsa04672,Intestinal immune network for IgA production;hsa:3127,path:hsa05310,Asthma;hsa:3127,path:hsa05322,Systemic lupus erythematosus;hsa:3127,path:hsa05323,Rheumatoid arthritis;hsa:3127,path:hsa05320,Autoimmune thyroid disease;hsa:3127,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3127,path:hsa05330,Allograft rejection;hsa:3127,path:hsa05332,Graft-versus-host disease;hsa:3127,path:hsa05416,Viral myocarditis;hsa:3127,path:hsa04940,Type I diabetes mellitus;hsa:3127,path:hsa05150,Staphylococcus aureus infection;hsa:3127,path:hsa05152,Tuberculosis;hsa:3127,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3127,path:hsa05164,Influenza A;hsa:3127,path:hsa05168,Herpes simplex virus 1 infection;hsa:3127,path:hsa05169,Epstein-Barr virus infection;hsa:3127,path:hsa05145,Toxoplasmosis;hsa:3127,path:hsa05140,Leishmaniasis;hsa:3118,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3118,path:hsa04145,Phagosome;hsa:3118,path:hsa04640,Hematopoietic cell lineage;hsa:3118,path:hsa04612,Antigen processing and presentation;hsa:3118,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3118,path:hsa04659,Th17 cell differentiation;hsa:3118,path:hsa04672,Intestinal immune network for IgA production;hsa:3118,path:hsa05310,Asthma;hsa:3118,path:hsa05322,Systemic lupus erythematosus;hsa:3118,path:hsa05323,Rheumatoid arthritis;hsa:3118,path:hsa05320,Autoimmune thyroid disease;hsa:3118,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3118,path:hsa05330,Allograft rejection;hsa:3118,path:hsa05332,Graft-versus-host disease;hsa:3118,path:hsa05416,Viral myocarditis;hsa:3118,path:hsa04940,Type I diabetes mellitus;hsa:3118,path:hsa05150,Staphylococcus aureus infection;hsa:3118,path:hsa05152,Tuberculosis;hsa:3118,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3118,path:hsa05164,Influenza A;hsa:3118,path:hsa05168,Herpes simplex virus 1 infection;hsa:3118,path:hsa05169,Epstein-Barr virus infection;hsa:3118,path:hsa05145,Toxoplasmosis;hsa:3118,path:hsa05140,Leishmaniasis;hsa:3117,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3117,path:hsa04145,Phagosome;hsa:3117,path:hsa04640,Hematopoietic cell lineage;hsa:3117,path:hsa04612,Antigen processing and presentation;hsa:3117,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3117,path:hsa04659,Th17 cell differentiation;hsa:3117,path:hsa04672,Intestinal immune network for IgA production;hsa:3117,path:hsa05310,Asthma;hsa:3117,path:hsa05322,Systemic lupus erythematosus;hsa:3117,path:hsa05323,Rheumatoid arthritis;hsa:3117,path:hsa05320,Autoimmune thyroid disease;hsa:3117,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3117,path:hsa05330,Allograft rejection;hsa:3117,path:hsa05332,Graft-versus-host disease;hsa:3117,path:hsa05416,Viral myocarditis;hsa:3117,path:hsa04940,Type I diabetes mellitus;hsa:3117,path:hsa05150,Staphylococcus aureus infection;hsa:3117,path:hsa05152,Tuberculosis;hsa:3117,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3117,path:hsa05164,Influenza A;hsa:3117,path:hsa05168,Herpes simplex virus 1 infection;hsa:3117,path:hsa05169,Epstein-Barr virus infection;hsa:3117,path:hsa05145,Toxoplasmosis;hsa:3117,path:hsa05140,Leishmaniasis
TRNT1_HUMAN	Q96Q11	TRNT1	CCA tRNA nucleotidyltransferase 1, mitochondrial	0.538747351	0.8474349	0.710740606	1.088727235	0.6930911255	0.8997339205	0.6930911255	0.8997339205	0.770328993614952	0.462380	0	1.2981466468077	0.462514	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0005524,ATP binding;GO:0052929,ATP;GO:0052928,CTP;GO:0052927,CTP;GO:0000049,tRNA binding;GO:0016437,tRNA cytidylyltransferase activity;GO:0016779,nucleotidyltransferase activity;GO:0003723,RNA binding	GO:1990180,mitochondrial tRNA 3'-end processing;GO:0042780,tRNA 3'-end processing;GO:0001680,tRNA 3'-terminal CCA addition;GO:0006396,RNA processing	hsa:51095,path:hsa03013,RNA transport
K2C1B_HUMAN	Q7Z794	KRT77	Keratin, type II cytoskeletal 1b	1.370454668	1.663930813	0.814113071	0.67625477	1.5171927405	0.7451839205	1.5171927405	0.7451839205	2.03599768964687	0.221507	0	0.491159692903896	0.220961	0	GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0045095,keratin filament		GO:0070268,cornification;GO:0031424,keratinization	
SMRC2_HUMAN	Q8TAQ2	SMARCC2	SWI/SNF complex subunit SMARCC2	0.318293535	0.243413267	0.52674529	0.396716846	0.280853401	0.461731068	0.280853401	0.461731068	0.608261865974329	0.324403	0	1.64402875790705	0.324673	0	GO:0000785,chromatin;GO:0071565,nBAF complex;GO:0071564,npBAF complex;GO:0005654,nucleoplasm;GO:0032991,protein-containing complex;GO:0016514,SWI/SNF complex	GO:0042393,histone binding;GO:0003713,transcription coactivator activity;GO:0003682,chromatin binding	GO:0043044,ATP-dependent chromatin remodeling;GO:0006338,chromatin remodeling;GO:0045892,negative regulation of transcription, DNA-templated;GO:0007399,nervous system development;GO:0006337,nucleosome disassembly;GO:0045893,positive regulation of transcription, DNA-templated;GO:0006357,regulation of transcription by RNA polymerase II;GO:0000122,negative regulation of transcription by RNA polymerase II	hsa:6601,path:hsa04714,Thermogenesis;hsa:6601,path:hsa05225,Hepatocellular carcinoma
EWS_HUMAN	Q01844	EWSR1	RNA-binding protein EWS	0.734139143	0.470209609	1.011385148	0.75540269	0.602174376	0.883393919	0.602174376	0.883393919	0.681660087361321	0.389233	0	1.46700682428241	0.389444	0	GO:0005737,cytoplasm;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0005516,calmodulin binding;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0003723,RNA binding;GO:0003712,transcription coregulator activity	GO:0006355,regulation of transcription, DNA-templated	hsa:2130,path:hsa05202,Transcriptional misregulation in cancer
AAK1_HUMAN	Q2M2I8	AAK1	AP2-associated protein kinase 1	0.153593986	0.211023132	0.263826947	0.214358772	0.182308559	0.2390928595	0.182308559	0.2390928595	0.76250106080646	0.456186	0	1.3114735852857	0.456326	0	GO:0031252,cell leading edge;GO:0005905,clathrin-coated pit;GO:0030136,clathrin-coated vesicle;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0019897,extrinsic component of plasma membrane;GO:0043195,terminal bouton	GO:0035612,AP-2 adaptor complex binding;GO:0005524,ATP binding;GO:0005112,Notch binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0004672,protein kinase activity	GO:0006897,endocytosis;GO:0061024,membrane organization;GO:0045747,positive regulation of Notch signaling pathway;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:0050821,protein stabilization;GO:2000369,regulation of clathrin-dependent endocytosis;GO:0032880,regulation of protein localization	
RBBP7_HUMAN	Q16576	RBBP7	Histone-binding protein RBBP7	2.55E-05	0.013168269	2.55E-05	2.55E-05	0.0065968845	2.55e-005	0.0065968845	2.55e-005	258.701352941176	0.000001	1	0.00386546103694858	0.000001	-1	GO:0005829,cytosol;GO:0035098,ESC/E(Z) complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016581,NuRD complex	GO:0003723,RNA binding	GO:0070370,cellular heat acclimation;GO:0034080,CENP-A containing nucleosome assembly;GO:0006260,DNA replication;GO:0030308,negative regulation of cell growth;GO:0070317,negative regulation of G0 to G1 transition;GO:0045814,negative regulation of gene expression, epigenetic;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0043687,post-translational protein modification;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0048545,response to steroid hormone;GO:0019058,viral life cycle	
IF2B2_HUMAN	Q9Y6M1	IGF2BP2	Insulin-like growth factor 2 mRNA-binding protein 2	0.148888624	0.194939074	0.285493717	0.086779859	0.171913849	0.186136788	0.171913849	0.186136788	0.923588780311391	0.459834	0	1.08273294491824	0.459695	0	GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005634,nucleus	GO:0003730,mRNA 3'-UTR binding;GO:0048027,mRNA 5'-UTR binding;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0045182,translation regulator activity	GO:0009653,anatomical structure morphogenesis;GO:0051028,mRNA transport;GO:0017148,negative regulation of translation;GO:0007399,nervous system development;GO:0001817,regulation of cytokine production;GO:0010468,regulation of gene expression;GO:0043488,regulation of mRNA stability;GO:0051252,regulation of RNA metabolic process	
TGM3_HUMAN	Q08188	TGM3	Protein-glutamine gamma-glutamyltransferase E	0.697665923	1.571164285	0.157101835	0.033325199	1.134415104	0.095213517	1.134415104	0.095213517	11.9144333676908	0.012027	1	0.0839318135524402	0.011867	-1	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0032991,protein-containing complex	GO:0005509,calcium ion binding;GO:0003824,catalytic activity;GO:0003810,protein-glutamine gamma-glutamyltransferase activity;GO:0005198,structural molecule activity;GO:0016746,transferase activity, transferring acyl groups	GO:0043163,cell envelope organization;GO:0006464,cellular protein modification process;GO:0031069,hair follicle morphogenesis;GO:0031424,keratinization;GO:0030216,keratinocyte differentiation;GO:0018149,peptide cross-linking	
MUC18_HUMAN	P43121	MCAM	Cell surface glycoprotein MUC18	0.178092807	0.080937771	0.470033051	2.996139629	0.129515289	1.73308634	0.129515289	1.73308634	0.0747310079196632	0.000126	-1	13.3813262772397	0.000128	1	GO:0009897,external side of plasma membrane;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0016021,integral component of membrane;GO:0005634,nucleus;GO:0005886,plasma membrane		GO:0009653,anatomical structure morphogenesis;GO:0001525,angiogenesis;GO:0007155,cell adhesion;GO:0003094,glomerular filtration;GO:0030335,positive regulation of cell migration;GO:0061042,vascular wound healing	
VPS51_HUMAN	Q9UID3	VPS51	Vacuolar protein sorting-associated protein 51 homolog	0.108247517	0.153762176	0.250421538	0.380071561	0.1310048465	0.3152465495	0.1310048465	0.3152465495	0.415563141635591	0.149722	0	2.40637318330051	0.150053	0	GO:0005829,cytosol;GO:1990745,EARP complex;GO:0000938,GARP complex;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005730,nucleolus;GO:0055037,recycling endosome;GO:0032588,trans-Golgi network membrane		GO:0006914,autophagy;GO:0048854,brain morphogenesis;GO:0032456,endocytic recycling;GO:0007030,Golgi organization;GO:0048193,Golgi vesicle transport;GO:0006869,lipid transport;GO:0007041,lysosomal transport;GO:0015031,protein transport;GO:0042147,retrograde transport, endosome to Golgi	
POTEF_HUMAN	A5A3E0	POTEF	POTE ankyrin domain family member F	0.027683162	0.083573638	0.210320605	2.55E-05	0.0556284	0.1051730525	0.0556284	0.1051730525	0.528922558371119	0.251744	0	1.89063594315134	0.252062	0	GO:0072562,blood microparticle;GO:0005938,cell cortex;GO:0070062,extracellular exosome;GO:0005615,extracellular space		GO:0001895,retina homeostasis	
NDUA4_HUMAN	O00483	NDUFA4	Cytochrome c oxidase subunit NDUFA4	3.437597489	0.753435221	0.981864102	2.206233943	2.095516355	1.5940490225	2.095516355	1.5940490225	1.3145871459546	0.345171	0	0.760695099657192	0.344797	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0005751,mitochondrial respiratory chain complex IV;GO:0005739,mitochondrion	GO:0008137,NADH dehydrogenase (ubiquinone) activity;GO:0044877,protein-containing complex binding	GO:0006123,mitochondrial electron transport, cytochrome c to oxygen;GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:1904960,positive regulation of cytochrome-c oxidase activity;GO:1902600,proton transmembrane transport	hsa:4697,path:hsa00190,Oxidative phosphorylation;hsa:4697,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4697,path:hsa04714,Thermogenesis;hsa:4697,path:hsa05010,Alzheimer disease;hsa:4697,path:hsa05012,Parkinson disease;hsa:4697,path:hsa05016,Huntington disease;hsa:4697,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
VMA5A_HUMAN	O00534	VWA5A	von Willebrand factor A domain-containing protein 5A	5.73320255	2.482655843	4.539811238	3.69930364	4.1079291965	4.119557439	4.1079291965	4.119557439	0.997177307836537	0.434289	0	1.00283068230823	0.434094	0	GO:0005654,nucleoplasm			
EIF3I_HUMAN	Q13347	EIF3I	Eukaryotic translation initiation factor 3 subunit I	1.726311616	1.202508113	1.818485875	1.478683715	1.4644098645	1.648584795	1.4644098645	1.648584795	0.888283010337967	0.472893	0	1.1257673380689	0.472783	0	GO:0005829,cytosol;GO:0016282,eukaryotic 43S preinitiation complex;GO:0033290,eukaryotic 48S preinitiation complex;GO:0005852,eukaryotic translation initiation factor 3 complex;GO:0071541,eukaryotic translation initiation factor 3 complex, eIF3m;GO:0070062,extracellular exosome	GO:0003723,RNA binding;GO:0003743,translation initiation factor activity	GO:0002183,cytoplasmic translational initiation;GO:0001732,formation of cytoplasmic translation initiation complex;GO:0006413,translational initiation	hsa:8668,path:hsa03013,RNA transport
VAPB_HUMAN	O95292	VAPB	Vesicle-associated membrane protein-associated protein B/C	0.229602516	0.235789768	0.121552599	0.039304795	0.232696142	0.080428697	0.232696142	0.080428697	2.89319795893249	0.143829	0	0.345638291673955	0.143263	0	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane;GO:0005886,plasma membrane	GO:0048487,beta-tubulin binding;GO:0045296,cadherin binding;GO:0019899,enzyme binding;GO:0033149,FFAT motif binding;GO:0008017,microtubule binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity	GO:0006874,cellular calcium ion homeostasis;GO:0090114,COPII-coated vesicle budding;GO:0090158,endoplasmic reticulum membrane organization;GO:0007029,endoplasmic reticulum organization;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0030968,endoplasmic reticulum unfolded protein response;GO:0061817,endoplasmic reticulum-plasma membrane tethering;GO:0036498,IRE1-mediated unfolded protein response;GO:0044830,modulation by host of viral RNA genome replication;GO:0019048,modulation by virus of host process;GO:0044828,negative regulation by host of viral genome replication;GO:0044790,negative regulation by host of viral release from host cell;GO:0046725,negative regulation by virus of viral protein levels in host cell;GO:0044829,positive regulation by host of viral genome replication;GO:0044791,positive regulation by host of viral release from host cell;GO:0045070,positive regulation of viral genome replication;GO:0030148,sphingolipid biosynthetic process	hsa:9217,path:hsa04979,Cholesterol metabolism
DDX21_HUMAN	Q9NR30	DDX21	Nucleolar RNA helicase 2	0.973023232	0.160096189	1.391449102	0.419029267	0.5665597105	0.9052391845	0.5665597105	0.9052391845	0.625867417364322	0.340237	0	1.59778248915919	0.340493	0	GO:0005694,chromosome;GO:0005829,cytosol;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005654,nucleoplasm	GO:0097322,7SK snRNA binding;GO:0005524,ATP binding;GO:0003725,double-stranded RNA binding;GO:0042802,identical protein binding;GO:0035198,miRNA binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0019843,rRNA binding;GO:0030515,snoRNA binding	GO:0051607,defense response to virus;GO:0045087,innate immune response;GO:0001649,osteoblast differentiation;GO:0045815,positive regulation of gene expression, epigenetic;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0002735,positive regulation of myeloid dendritic cell cytokine production;GO:0062176,R-loop disassembly;GO:0043330,response to exogenous dsRNA;GO:0006364,rRNA processing;GO:0006366,transcription by RNA polymerase II	
FETUA_HUMAN	P02765	AHSG	Alpha-2-HS-glycoprotein	1.78159437	2.28020499	2.775768252	18.45060131	2.03089968	10.613184781	2.03089968	10.613184781	0.191356291434384	0.013116	-1	5.22585378564834	0.013210	1	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005794,Golgi apparatus;GO:0031093,platelet alpha granule lumen;GO:0034774,secretory granule lumen	GO:0004869,cysteine-type endopeptidase inhibitor activity;GO:0004866,endopeptidase inhibitor activity;GO:0019210,kinase inhibitor activity	GO:0006953,acute-phase response;GO:0044267,cellular protein metabolic process;GO:0030502,negative regulation of bone mineralization;GO:0010951,negative regulation of endopeptidase activity;GO:0046627,negative regulation of insulin receptor signaling pathway;GO:0043312,neutrophil degranulation;GO:0006907,pinocytosis;GO:0002576,platelet degranulation;GO:0050766,positive regulation of phagocytosis;GO:0043687,post-translational protein modification;GO:0030500,regulation of bone mineralization;GO:0050727,regulation of inflammatory response;GO:0001501,skeletal system development;GO:0001503,ossification	
CO7A1_HUMAN	Q02388	COL7A1	Collagen alpha-1(VII) chain	3.17616415	1.772370188	2.036679165	10.48366036	2.474267169	6.2601697625	2.474267169	6.2601697625	0.395239628136203	0.132585	0	2.53011066910374	0.132908	0	GO:0005604,basement membrane;GO:0005590,collagen type VII trimer;GO:0062023,collagen-containing extracellular matrix;GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005788,endoplasmic reticulum lumen;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0030020,extracellular matrix structural constituent conferring tensile strength;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0007155,cell adhesion;GO:0030199,collagen fibril organization;GO:0048208,COPII vesicle coating;GO:0035987,endodermal cell differentiation;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0008544,epidermis development;GO:0030198,extracellular matrix organization	hsa:1294,path:hsa04974,Protein digestion and absorption
DDX3X_HUMAN	O00571	DDX3X	ATP-dependent RNA helicase DDX3X	7.217296845	3.425309106	5.887333307	6.056654816	5.3213029755	5.9719940615	5.3213029755	5.9719940615	0.891042911412982	0.471853	0	1.12228040556906	0.471740	0	GO:0031252,cell leading edge;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0030027,lamellipodium;GO:0072559,NLRP3 inflammasome complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0043186,P granule;GO:0005886,plasma membrane;GO:0034774,secretory granule lumen;GO:0016021,integral component of membrane	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0045296,cadherin binding;GO:0043273,CTPase activity;GO:0003677,DNA binding;GO:0003678,DNA helicase activity;GO:0008190,eukaryotic initiation factor 4E binding;GO:0043015,gamma-tubulin binding;GO:0003924,GTPase activity;GO:0048027,mRNA 5'-UTR binding;GO:0003729,mRNA binding;GO:0017111,nucleoside-triphosphatase activity;GO:0008143,poly(A) binding;GO:0043539,protein serine/threonine kinase activator activity;GO:0043024,ribosomal small subunit binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0035613,RNA stem-loop binding;GO:0033592,RNA strand annealing activity;GO:0008134,transcription factor binding;GO:0031369,translation initiation factor binding;GO:0016787,hydrolase activity;GO:0003676,nucleic acid binding	GO:0030154,cell differentiation;GO:0071243,cellular response to arsenic-containing substance;GO:0071470,cellular response to osmotic stress;GO:0098586,cellular response to virus;GO:0007059,chromosome segregation;GO:0008625,extrinsic apoptotic signaling pathway via death domain receptors;GO:0007276,gamete generation;GO:0045087,innate immune response;GO:0035556,intracellular signal transduction;GO:0097193,intrinsic apoptotic signaling pathway;GO:0055088,lipid homeostasis;GO:0042256,mature ribosome assembly;GO:0043066,negative regulation of apoptotic process;GO:0030308,negative regulation of cell growth;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:1902042,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:2001243,negative regulation of intrinsic apoptotic signaling pathway;GO:1901223,negative regulation of NIK/NF-kappaB signaling;GO:0031333,negative regulation of protein-containing complex assembly;GO:0017148,negative regulation of translation;GO:0043312,neutrophil degranulation;GO:0043065,positive regulation of apoptotic process;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0030307,positive regulation of cell growth;GO:0071651,positive regulation of chemokine (C-C motif) ligand 5 production;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:1900087,positive regulation of G1/S transition of mitotic cell cycle;GO:0010628,positive regulation of gene expression;GO:0032727,positive regulation of interferon-alpha production;GO:0032728,positive regulation of interferon-beta production;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:1900227,positive regulation of NLRP3 inflammasome complex assembly;GO:1901985,positive regulation of protein acetylation;GO:0031954,positive regulation of protein autophosphorylation;GO:1902523,positive regulation of protein K63-linked ubiquitination;GO:0071902,positive regulation of protein serine/threonine kinase activity;GO:0034157,positive regulation of toll-like receptor 7 signaling pathway;GO:0034161,positive regulation of toll-like receptor 8 signaling pathway;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045727,positive regulation of translation;GO:0036493,positive regulation of translation in response to endoplasmic reticulum stress;GO:0045948,positive regulation of translational initiation;GO:0045070,positive regulation of viral genome replication;GO:1903608,protein localization to cytoplasmic stress granule;GO:0009615,response to virus;GO:0010501,RNA secondary structure unwinding;GO:0034063,stress granule assembly;GO:0006413,translational initiation;GO:0016032,viral process;GO:0016055,Wnt signaling pathway;GO:0031053,primary miRNA processing	hsa:1654,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:1654,path:hsa05203,Viral carcinogenesis;hsa:1654,path:hsa05161,Hepatitis B
RSSA_HUMAN	P08865	RPSA	40S ribosomal protein SA	20.73691181	27.14171566	26.30329795	16.20479051	23.939313735	21.25404423	23.939313735	21.25404423	1.1263415788516	0.394300	0	0.887830138544279	0.394022	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0015935,small ribosomal subunit	GO:0043236,laminin binding;GO:0005055,laminin receptor activity;GO:0043022,ribosome binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome;GO:0001618,virus receptor activity	GO:0007155,cell adhesion;GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000028,ribosomal small subunit assembly;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:3921,path:hsa03010,Ribosome
PNCB_HUMAN	Q6XQN6	NAPRT	Nicotinate phosphoribosyltransferase	0.595405551	0.934632999	0.745408261	1.347674514	0.765019275	1.0465413875	0.765019275	1.0465413875	0.730997630994312	0.430725	0	1.36799348944509	0.430893	0	GO:0035578,azurophil granule lumen;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region	GO:0046872,metal ion binding;GO:0004516,nicotinate phosphoribosyltransferase activity;GO:0004514,nicotinate-nucleotide diphosphorylase (carboxylating) activity	GO:0034356,NAD biosynthesis via nicotinamide riboside salvage pathway;GO:0034355,NAD salvage;GO:0043312,neutrophil degranulation;GO:0006979,response to oxidative stress;GO:0009435,NAD biosynthetic process	hsa:93100,path:hsa00760,Nicotinate and nicotinamide metabolism
PTN1_HUMAN	P18031	PTPN1	Tyrosine-protein phosphatase non-receptor type 1	1.314795209	0.62983946	2.690491102	1.255839847	0.9723173345	1.9731654745	0.9723173345	1.9731654745	0.492770295783928	0.218518	0	2.02934310074259	0.218849	0	GO:0098554,cytoplasmic side of endoplasmic reticulum membrane;GO:0005829,cytosol;GO:0005769,early endosome;GO:0005783,endoplasmic reticulum;GO:0030061,mitochondrial crista;GO:0005759,mitochondrial matrix;GO:0032991,protein-containing complex;GO:0097443,sorting endosome;GO:0016021,integral component of membrane	GO:0045296,cadherin binding;GO:0019899,enzyme binding;GO:0046875,ephrin receptor binding;GO:0005158,insulin receptor binding;GO:0019901,protein kinase binding;GO:0051721,protein phosphatase 2A binding;GO:0004725,protein tyrosine phosphatase activity;GO:0030971,receptor tyrosine kinase binding;GO:0003723,RNA binding;GO:0008270,zinc ion binding	GO:0031532,actin cytoskeleton reorganization;GO:0007257,activation of JUN kinase activity;GO:0034620,cellular response to unfolded protein;GO:0030968,endoplasmic reticulum unfolded protein response;GO:0060397,growth hormone receptor signaling pathway via JAK-STAT;GO:0008286,insulin receptor signaling pathway;GO:0036498,IRE1-mediated unfolded protein response;GO:1902236,negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:0046627,negative regulation of insulin receptor signaling pathway;GO:0043407,negative regulation of MAP kinase activity;GO:1903898,negative regulation of PERK-mediated unfolded protein response;GO:0009968,negative regulation of signal transduction;GO:0030948,negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0035335,peptidyl-tyrosine dephosphorylation;GO:1990264,peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;GO:0035791,platelet-derived growth factor receptor-beta signaling pathway;GO:1903896,positive regulation of IRE1-mediated unfolded protein response;GO:0061098,positive regulation of protein tyrosine kinase activity;GO:2000646,positive regulation of receptor catabolic process;GO:0006470,protein dephosphorylation;GO:0030100,regulation of endocytosis;GO:1902202,regulation of hepatocyte growth factor receptor signaling pathway;GO:0033157,regulation of intracellular protein transport;GO:0009966,regulation of signal transduction;GO:0060338,regulation of type I interferon-mediated signaling pathway	hsa:5770,path:hsa04520,Adherens junction;hsa:5770,path:hsa04910,Insulin signaling pathway;hsa:5770,path:hsa04931,Insulin resistance
KCY_HUMAN	P30085	CMPK1	UMP-CMP kinase	2.429136026	4.85370101	0.445631841	0.189356714	3.641418518	0.3174942775	3.641418518	0.3174942775	11.4692414196347	0.013069	1	0.0871897245347067	0.012899	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0036430,CMP kinase activity;GO:0004127,cytidylate kinase activity;GO:0036431,dCMP kinase activity;GO:0004550,nucleoside diphosphate kinase activity;GO:0033862,UMP kinase activity;GO:0004849,uridine kinase activity	GO:0006207,'de novo' pyrimidine nucleobase biosynthetic process;GO:0046705,CDP biosynthetic process;GO:0015949,nucleobase-containing small molecule interconversion;GO:0006165,nucleoside diphosphate phosphorylation;GO:0009142,nucleoside triphosphate biosynthetic process;GO:0009220,pyrimidine ribonucleotide biosynthetic process;GO:0006225,UDP biosynthetic process	hsa:51727,path:hsa00240,Pyrimidine metabolism;hsa:51727,path:hsa00983,Drug metabolism - other enzymes
VWA8_HUMAN	A3KMH1	VWA8	von Willebrand factor A domain-containing protein 8	0.230424593	0.148525858	0.32173577	0.230922188	0.1894752255	0.276328979	0.1894752255	0.276328979	0.685687133451175	0.392689	0	1.45839108131844	0.392897	0	GO:0005737,cytoplasm;GO:0005739,mitochondrion;GO:0005777,peroxisome	GO:0005524,ATP binding;GO:0016887,ATPase activity		
H2A2B_HUMAN	Q8IUE6	H2AC21	Histone H2A type 2-B	2.399108917	6.40838084	2.55E-05	2.55E-05	4.4037448785	2.55e-005	4.4037448785	2.55e-005	172695.877588235	0.000000	1	5.79052617795738e-006	0.000000	-1	GO:0070062,extracellular exosome;GO:0000786,nucleosome;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0046982,protein heterodimerization activity	GO:0006342,chromatin silencing	hsa:317772,path:hsa04217,Necroptosis;hsa:317772,path:hsa05322,Systemic lupus erythematosus;hsa:317772,path:hsa05034,Alcoholism
SMCA5_HUMAN	O60264	SMARCA5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5	1.096338821	0.400471627	0.913887394	1.434313748	0.748405224	1.174100571	0.748405224	1.174100571	0.637428549551399	0.350547	0	1.56880328109522	0.350794	0	GO:0005677,chromatin silencing complex;GO:0000793,condensed chromosome;GO:0005829,cytosol;GO:0001650,fibrillar center;GO:0043231,intracellular membrane-bounded organelle;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016589,NURF complex;GO:0031213,RSF complex	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0008094,ATPase activity, acting on DNA;GO:0003677,DNA binding;GO:0004386,helicase activity;GO:0031491,nucleosome binding;GO:0070615,nucleosome-dependent ATPase activity	GO:0043044,ATP-dependent chromatin remodeling;GO:1990830,cellular response to leukemia inhibitory factor;GO:0034080,CENP-A containing nucleosome assembly;GO:0006338,chromatin remodeling;GO:0006352,DNA-templated transcription, initiation;GO:0006302,double-strand break repair;GO:0006334,nucleosome assembly;GO:0016584,nucleosome positioning;GO:0045815,positive regulation of gene expression, epigenetic;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0000183,rDNA heterochromatin assembly;GO:0006357,regulation of transcription by RNA polymerase II	
DESM_HUMAN	P17661	DES	Desmin	1.573726872	1.54919843	8.66545211	16.22328453	1.561462651	12.44436832	1.561462651	12.44436832	0.125475444863721	0.002067	-1	7.96968682666237	0.002090	1	GO:0097512,cardiac myofibril;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005916,fascia adherens;GO:0014704,intercalated disc;GO:0005882,intermediate filament;GO:0045111,intermediate filament cytoskeleton;GO:0031594,neuromuscular junction;GO:0005634,nucleus;GO:0042383,sarcolemma;GO:0030018,Z disc	GO:0008092,cytoskeletal protein binding;GO:0042802,identical protein binding;GO:0005200,structural constituent of cytoskeleton	GO:0007010,cytoskeleton organization;GO:0045109,intermediate filament organization;GO:0006936,muscle contraction;GO:0030049,muscle filament sliding;GO:0008016,regulation of heart contraction	hsa:1674,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:1674,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:1674,path:hsa05414,Dilated cardiomyopathy (DCM)
BUB3_HUMAN	O43684	BUB3	Mitotic checkpoint protein BUB3	1.362763586	0.673467632	1.528039619	0.509595663	1.018115609	1.018817641	1.018115609	1.018817641	0.999310934585594	0.433580	0	1.00068954055295	0.433383	0	GO:1990298,bub1-bub3 complex;GO:0000777,condensed chromosome kinetochore;GO:0005829,cytosol;GO:0000776,kinetochore;GO:0033597,mitotic checkpoint complex;GO:0005654,nucleoplasm	GO:0043130,ubiquitin binding	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0008608,attachment of spindle microtubules to kinetochore;GO:0051301,cell division;GO:0051321,meiotic cell cycle;GO:0000070,mitotic sister chromatid segregation;GO:0007094,mitotic spindle assembly checkpoint;GO:0007052,mitotic spindle organization;GO:0034501,protein localization to kinetochore;GO:0007096,regulation of exit from mitosis;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:9184,path:hsa04110,Cell cycle;hsa:9184,path:hsa05166,Human T-cell leukemia virus 1 infection
TFG_HUMAN	Q92734	TFG	Protein TFG	0.269672825	0.349457735	0.385065116	0.1100946	0.30956528	0.247579858	0.30956528	0.247579858	1.2503653669597	0.360855	0	0.799766233474245	0.360510	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070971,endoplasmic reticulum exit site;GO:0043231,intracellular membrane-bounded organelle	GO:0042802,identical protein binding	GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling	hsa:10342,path:hsa05200,Pathways in cancer;hsa:10342,path:hsa05216,Thyroid cancer
A16A1_HUMAN	Q8IZ83	ALDH16A1	Aldehyde dehydrogenase family 16 member A1	1.376596959	1.084970626	1.620213282	3.178426565	1.2307837925	2.3993199235	1.2307837925	2.3993199235	0.512971938608586	0.237056	0	1.94942437341203	0.237380	0	GO:0016020,membrane	GO:0016620,oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor		
LCN1_HUMAN	P31025	LCN1	Lipocalin-1	0.130606241	0.183734268	0.095164898	0.199738075	0.1571702545	0.1474514865	0.1571702545	0.1474514865	1.06591163121302	0.412294	0	0.938164075442151	0.412052	0	GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0031404,chloride ion binding;GO:0004869,cysteine-type endopeptidase inhibitor activity;GO:0005102,signaling receptor binding;GO:0036094,small molecule binding;GO:0008270,zinc ion binding	GO:0015909,long-chain fatty acid transport;GO:0006508,proteolysis;GO:0050896,response to stimulus;GO:0001895,retina homeostasis;GO:0050909,sensory perception of taste	
TSP1_HUMAN	P07996	THBS1	Thrombospondin-1	32.1928434	8.691348869	6.214204516	9.449626087	20.4420961345	7.8319153015	20.4420961345	7.8319153015	2.61010178833074	0.164413	0	0.383126820751132	0.163842	0	GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005577,fibrinogen complex;GO:0031091,platelet alpha granule;GO:0031093,platelet alpha granule lumen;GO:0016529,sarcoplasmic reticulum;GO:0030141,secretory granule	GO:0005509,calcium ion binding;GO:0070052,collagen V binding;GO:0005201,extracellular matrix structural constituent;GO:0070051,fibrinogen binding;GO:0017134,fibroblast growth factor binding;GO:0001968,fibronectin binding;GO:0008201,heparin binding;GO:0042802,identical protein binding;GO:0005178,integrin binding;GO:0043236,laminin binding;GO:0030169,low-density lipoprotein particle binding;GO:0001786,phosphatidylserine binding;GO:0043394,proteoglycan binding;GO:0050431,transforming growth factor beta binding;GO:0050840,extracellular matrix binding	GO:0000187,activation of MAPK activity;GO:0048266,behavioral response to pain;GO:0007155,cell adhesion;GO:0007050,cell cycle arrest;GO:0016477,cell migration;GO:0071363,cellular response to growth factor stimulus;GO:0034605,cellular response to heat;GO:0071356,cellular response to tumor necrosis factor;GO:0002544,chronic inflammatory response;GO:0043652,engulfment of apoptotic cell;GO:0030198,extracellular matrix organization;GO:0006955,immune response;GO:0006954,inflammatory response;GO:0016525,negative regulation of angiogenesis;GO:0002581,negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0043066,negative regulation of apoptotic process;GO:0043537,negative regulation of blood vessel endothelial cell migration;GO:1903588,negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0090051,negative regulation of cell migration involved in sprouting angiogenesis;GO:0001953,negative regulation of cell-matrix adhesion;GO:0010754,negative regulation of cGMP-mediated signaling;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0002605,negative regulation of dendritic cell antigen processing and presentation;GO:2001027,negative regulation of endothelial cell chemotaxis;GO:0010596,negative regulation of endothelial cell migration;GO:0001937,negative regulation of endothelial cell proliferation;GO:2001237,negative regulation of extrinsic apoptotic signaling pathway;GO:0051918,negative regulation of fibrinolysis;GO:0040037,negative regulation of fibroblast growth factor receptor signaling pathway;GO:0051895,negative regulation of focal adhesion assembly;GO:0032695,negative regulation of interleukin-12 production;GO:0010748,negative regulation of long-chain fatty acid import across plasma membrane;GO:0010751,negative regulation of nitric oxide mediated signal transduction;GO:0010757,negative regulation of plasminogen activation;GO:1903671,negative regulation of sprouting angiogenesis;GO:0018149,peptide cross-linking;GO:0002576,platelet degranulation;GO:0045766,positive regulation of angiogenesis;GO:0030194,positive regulation of blood coagulation;GO:0043536,positive regulation of blood vessel endothelial cell migration;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0050921,positive regulation of chemotaxis;GO:2000353,positive regulation of endothelial cell apoptotic process;GO:0010595,positive regulation of endothelial cell migration;GO:1902043,positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0010763,positive regulation of fibroblast migration;GO:0043032,positive regulation of macrophage activation;GO:0010759,positive regulation of macrophage chemotaxis;GO:0042327,positive regulation of phosphorylation;GO:0051897,positive regulation of protein kinase B signaling;GO:2000379,positive regulation of reactive oxygen species metabolic process;GO:0048661,positive regulation of smooth muscle cell proliferation;GO:0030511,positive regulation of transforming growth factor beta receptor signaling pathway;GO:0032914,positive regulation of transforming growth factor beta1 production;GO:0045727,positive regulation of translation;GO:0032760,positive regulation of tumor necrosis factor production;GO:0045652,regulation of megakaryocyte differentiation;GO:0051592,response to calcium ion;GO:0042493,response to drug;GO:0034976,response to endoplasmic reticulum stress;GO:0009749,response to glucose;GO:0001666,response to hypoxia;GO:0032026,response to magnesium ion;GO:0009612,response to mechanical stimulus;GO:0032570,response to progesterone;GO:0033574,response to testosterone;GO:0006986,response to unfolded protein;GO:0002040,sprouting angiogenesis	hsa:7057,path:hsa04015,Rap1 signaling pathway;hsa:7057,path:hsa04350,TGF-beta signaling pathway;hsa:7057,path:hsa04151,PI3K-Akt signaling pathway;hsa:7057,path:hsa04512,ECM-receptor interaction;hsa:7057,path:hsa04145,Phagosome;hsa:7057,path:hsa04115,p53 signaling pathway;hsa:7057,path:hsa04510,Focal adhesion;hsa:7057,path:hsa05206,MicroRNAs in cancer;hsa:7057,path:hsa05205,Proteoglycans in cancer;hsa:7057,path:hsa05219,Bladder cancer;hsa:7057,path:hsa05165,Human papillomavirus infection;hsa:7057,path:hsa05144,Malaria
STK4_HUMAN	Q13043	STK4	Serine/threonine-protein kinase 4	0.097353639	0.106577441	0.26208272	0.095278646	0.10196554	0.178680683	0.10196554	0.178680683	0.570657881355871	0.290150	0	1.75236342591821	0.290446	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0000287,magnesium ion binding;GO:0042803,protein homodimerization activity;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0043539,protein serine/threonine kinase activator activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0008134,transcription factor binding	GO:0032147,activation of protein kinase activity;GO:0006915,apoptotic process;GO:0001569,branching involved in blood vessel morphogenesis;GO:0060706,cell differentiation involved in embryonic placenta development;GO:0000902,cell morphogenesis;GO:0007417,central nervous system development;GO:0003157,endocardium development;GO:0097284,hepatocyte apoptotic process;GO:0035329,hippo signaling;GO:0035556,intracellular signal transduction;GO:0030216,keratinocyte differentiation;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0008285,negative regulation of cell population proliferation;GO:0046621,negative regulation of organ growth;GO:0001841,neural tube formation;GO:0018105,peptidyl-serine phosphorylation;GO:0043065,positive regulation of apoptotic process;GO:1902043,positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0045600,positive regulation of fat cell differentiation;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0032092,positive regulation of protein binding;GO:0001934,positive regulation of protein phosphorylation;GO:1904237,positive regulation of substrate-dependent cell migration, cell attachment to substrate;GO:1905461,positive regulation of vascular associated smooth muscle cell apoptotic process;GO:0060215,primitive hemopoiesis;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:0050821,protein stabilization;GO:0060800,regulation of cell differentiation involved in embryonic placenta development;GO:0007165,signal transduction;GO:0031098,stress-activated protein kinase signaling cascade	hsa:6789,path:hsa04014,Ras signaling pathway;hsa:6789,path:hsa04010,MAPK signaling pathway;hsa:6789,path:hsa04068,FoxO signaling pathway;hsa:6789,path:hsa05200,Pathways in cancer;hsa:6789,path:hsa05223,Non-small cell lung cancer
GLCM_HUMAN	P04062	GBA	Lysosomal acid glucosylceramidase	0.93959738	0.677196231	1.178766633	0.887816473	0.8083968055	1.033291553	0.8083968055	1.033291553	0.782351121668368	0.471789	0	1.27819846141141	0.471912	0	GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0019898,extrinsic component of membrane;GO:0005794,Golgi apparatus;GO:0043202,lysosomal lumen;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0005802,trans-Golgi network	GO:0004348,glucosylceramidase activity;GO:0046527,glucosyltransferase activity;GO:0005124,scavenger receptor binding;GO:0005102,signaling receptor binding;GO:0050295,steryl-beta-glucosidase activity;GO:0016757,transferase activity, transferring glycosyl groups	GO:0019882,antigen processing and presentation;GO:1905037,autophagosome organization;GO:0006914,autophagy;GO:1901805,beta-glucoside catabolic process;GO:0048854,brain morphogenesis;GO:0048469,cell maturation;GO:0009267,cellular response to starvation;GO:0071356,cellular response to tumor necrosis factor;GO:0046513,ceramide biosynthetic process;GO:0021694,cerebellar Purkinje cell layer formation;GO:0008203,cholesterol metabolic process;GO:0008340,determination of adult lifespan;GO:0006680,glucosylceramide catabolic process;GO:0006687,glycosphingolipid metabolic process;GO:0071425,hematopoietic stem cell proliferation;GO:0048872,homeostasis of number of cells;GO:0030259,lipid glycosylation;GO:0019915,lipid storage;GO:0072676,lymphocyte migration;GO:0007040,lysosome organization;GO:0014004,microglia differentiation;GO:0061518,microglial cell proliferation;GO:0061744,motor behavior;GO:0050728,negative regulation of inflammatory response;GO:0032715,negative regulation of interleukin-6 production;GO:0043407,negative regulation of MAP kinase activity;GO:0043524,negative regulation of neuron apoptotic process;GO:1901215,negative regulation of neuron death;GO:0031333,negative regulation of protein-containing complex assembly;GO:0050905,neuromuscular process;GO:0051402,neuron apoptotic process;GO:1904925,positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization;GO:1904457,positive regulation of neuronal action potential;GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0035307,positive regulation of protein dephosphorylation;GO:1903061,positive regulation of protein lipidation;GO:0051247,positive regulation of protein metabolic process;GO:0043243,positive regulation of protein-containing complex disassembly;GO:1903052,positive regulation of proteolysis involved in cellular protein catabolic process;GO:0021859,pyramidal neuron differentiation;GO:0032268,regulation of cellular protein metabolic process;GO:1905165,regulation of lysosomal protein catabolic process;GO:0016241,regulation of macroautophagy;GO:0032006,regulation of TOR signaling;GO:0033561,regulation of water loss via skin;GO:0071548,response to dexamethasone;GO:0043627,response to estrogen;GO:0009268,response to pH;GO:0033574,response to testosterone;GO:0097066,response to thyroid hormone;GO:0043589,skin morphogenesis;GO:0046512,sphingosine biosynthetic process;GO:0033077,T cell differentiation in thymus;GO:0023021,termination of signal transduction;GO:0006665,sphingolipid metabolic process	hsa:2629,path:hsa00600,Sphingolipid metabolism;hsa:2629,path:hsa00511,Other glycan degradation;hsa:2629,path:hsa04142,Lysosome
SPON1_HUMAN	Q9HCB6	SPON1	Spondin-1	0.492186583	0.695443902	0.671239065	1.430609565	0.5938152425	1.050924315	0.5938152425	1.050924315	0.565040920668012	0.284996	0	1.76978332616647	0.285295	0	GO:0005788,endoplasmic reticulum lumen;GO:0031012,extracellular matrix;GO:0005615,extracellular space	GO:0005201,extracellular matrix structural constituent;GO:0050693,LBD domain binding;GO:0046872,metal ion binding	GO:0007155,cell adhesion;GO:1902430,negative regulation of amyloid-beta formation;GO:1902993,positive regulation of amyloid precursor protein catabolic process;GO:0032092,positive regulation of protein binding;GO:0010954,positive regulation of protein processing	
MAGT1_HUMAN	Q9H0U3	MAGT1	Magnesium transporter protein 1	0.978450817	2.060757201	1.155524052	0.705822219	1.519604009	0.9306731355	1.519604009	0.9306731355	1.63280098139246	0.280586	0	0.612444511851772	0.280107	0	GO:0035577,azurophil granule membrane;GO:0005783,endoplasmic reticulum;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0008250,oligosaccharyltransferase complex;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0015095,magnesium ion transmembrane transporter activity	GO:0050890,cognition;GO:0015693,magnesium ion transport;GO:0043312,neutrophil degranulation;GO:0006487,protein N-linked glycosylation;GO:0018279,protein N-linked glycosylation via asparagine;GO:0055085,transmembrane transport;GO:0019082,viral protein processing	
TGM1_HUMAN	P22735	TGM1	Protein-glutamine gamma-glutamyltransferase K	0.101405744	0.369021759	0.082132439	0.071718965	0.2352137515	0.076925702	0.2352137515	0.076925702	3.05767442330263	0.133526	0	0.327045938043295	0.132965	0	GO:0001533,cornified envelope;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0031224,intrinsic component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0003810,protein-glutamine gamma-glutamyltransferase activity	GO:0043163,cell envelope organization;GO:0006464,cellular protein modification process;GO:0070268,cornification;GO:0030216,keratinocyte differentiation;GO:0018149,peptide cross-linking;GO:0045787,positive regulation of cell cycle;GO:0010838,positive regulation of keratinocyte proliferation	
PTER_HUMAN	Q96BW5	PTER	Phosphotriesterase-related protein	0.238544053	0.401464611	0.491037765	0.173011332	0.320004332	0.3320245485	0.320004332	0.3320245485	0.963797205494882	0.445607	0	1.03756266805788	0.445436	0	GO:0070062,extracellular exosome	GO:0016788,hydrolase activity, acting on ester bonds;GO:0008270,zinc ion binding	GO:0009056,catabolic process;GO:0030855,epithelial cell differentiation	
PHYD1_HUMAN	Q5SRE7	PHYHD1	Phytanoyl-CoA dioxygenase domain-containing protein 1	0.044511943	0.127546924	0.298752183	0.187461427	0.0860294335	0.243106805	0.0860294335	0.243106805	0.3538750529834	0.099711	0	2.82585616468113	0.100010	0		GO:0051213,dioxygenase activity;GO:0046872,metal ion binding		
HMGCL_HUMAN	P35914	HMGCL	Hydroxymethylglutaryl-CoA lyase, mitochondrial	2.392649455	0.86455335	1.910155198	10.12858753	1.6286014025	6.019371364	1.6286014025	6.019371364	0.270560047555823	0.045185	-1	3.69603719778204	0.045392	1	GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005782,peroxisomal matrix;GO:0005777,peroxisome;GO:0032991,protein-containing complex	GO:0031406,carboxylic acid binding;GO:0000062,fatty-acyl-CoA binding;GO:0004419,hydroxymethylglutaryl-CoA lyase activity;GO:0000287,magnesium ion binding;GO:0030145,manganese ion binding;GO:0046872,metal ion binding;GO:0005198,structural molecule activity	GO:0006637,acyl-CoA metabolic process;GO:0046951,ketone body biosynthetic process;GO:0006552,leucine catabolic process;GO:0006629,lipid metabolic process;GO:0001889,liver development;GO:0007005,mitochondrion organization;GO:0008104,protein localization;GO:0070542,response to fatty acid;GO:0007584,response to nutrient;GO:0042594,response to starvation	hsa:3155,path:hsa00650,Butanoate metabolism;hsa:3155,path:hsa00072,Synthesis and degradation of ketone bodies;hsa:3155,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:3155,path:hsa04146,Peroxisome
SPT6H_HUMAN	Q7KZ85	SUPT6H	Transcription elongation factor SPT6	0.330163835	0.343220107	0.408057729	1.892486646	0.336691971	1.1502721875	0.336691971	1.1502721875	0.29270634781822	0.057835	0	3.41639328102659	0.058071	0	GO:0005654,nucleoplasm;GO:0008023,transcription elongation factor complex;GO:0035327,transcriptionally active chromatin	GO:0003677,DNA binding;GO:0042393,histone binding;GO:0031491,nucleosome binding;GO:0003723,RNA binding	GO:0001825,blastocyst formation;GO:0070827,chromatin maintenance;GO:0006397,mRNA processing;GO:0042789,mRNA transcription by RNA polymerase II;GO:0051028,mRNA transport;GO:0061086,negative regulation of histone H3-K27 methylation;GO:0034728,nucleosome organization;GO:0032968,positive regulation of transcription elongation from RNA polymerase II promoter;GO:0045191,regulation of isotype switching;GO:0010793,regulation of mRNA export from nucleus;GO:0050684,regulation of mRNA processing;GO:0051147,regulation of muscle cell differentiation;GO:0008380,RNA splicing;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter;GO:0016032,viral process	
TBAL3_HUMAN	A6NHL2	TUBAL3	Tubulin alpha chain-like 3	6.939235819	8.294807496	9.361645645	8.686534956	7.6170216575	9.0240903005	7.6170216575	9.0240903005	0.844076400374447	0.490038	0	1.18472687964784	0.489966	0	GO:0005737,cytoplasm;GO:0005874,microtubule	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0005200,structural constituent of cytoskeleton	GO:0000226,microtubule cytoskeleton organization;GO:0000278,mitotic cell cycle	hsa:79861,path:hsa04145,Phagosome;hsa:79861,path:hsa04210,Apoptosis;hsa:79861,path:hsa04530,Tight junction;hsa:79861,path:hsa04540,Gap junction;hsa:79861,path:hsa05130,Pathogenic Escherichia coli infection
PPCS_HUMAN	Q9HAB8	PPCS	Phosphopantothenate--cysteine ligase	1.557320971	0.835111309	1.220811238	1.243232501	1.19621614	1.2320218695	1.19621614	1.2320218695	0.970937423769489	0.443149	0	1.02993249154789	0.442973	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0004632,phosphopantothenate--cysteine ligase activity;GO:0042803,protein homodimerization activity	GO:0006085,acetyl-CoA biosynthetic process;GO:0015937,coenzyme A biosynthetic process;GO:0003015,heart process	hsa:79717,path:hsa00770,Pantothenate and CoA biosynthesis
PON1_HUMAN	P27169	PON1	Serum paraoxonase/arylesterase 1	0.429809567	0.368482197	0.621018009	3.876791336	0.399145882	2.2489046725	0.399145882	2.2489046725	0.177484571436409	0.009700	-1	5.63429255797759	0.009776	1	GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0034364,high-density lipoprotein particle;GO:0043231,intracellular membrane-bounded organelle;GO:0034366,spherical high-density lipoprotein particle	GO:0102007,acyl-L-homoserine-lactone lactonohydrolase activity;GO:0004063,aryldialkylphosphatase activity;GO:0004064,arylesterase activity;GO:0005509,calcium ion binding;GO:0005543,phospholipid binding;GO:0042803,protein homodimerization activity	GO:0019439,aromatic compound catabolic process;GO:0046395,carboxylic acid catabolic process;GO:0008203,cholesterol metabolic process;GO:0019372,lipoxygenase pathway;GO:0046434,organophosphate catabolic process;GO:0046470,phosphatidylcholine metabolic process;GO:0051099,positive regulation of binding;GO:0010875,positive regulation of cholesterol efflux;GO:0032411,positive regulation of transporter activity;GO:0070542,response to fatty acid;GO:1902617,response to fluoride;GO:0031667,response to nutrient levels;GO:0009636,response to toxic substance	
RPR1A_HUMAN	Q96P16	RPRD1A	Regulation of nuclear pre-mRNA domain-containing protein 1A	0.040715597	2.55E-05	0.034857198	0.01940272	0.0203705485	0.027129959	0.0203705485	0.027129959	0.750850692402447	0.446868	0	1.33182270472491	0.447019	0	GO:0005654,nucleoplasm;GO:0016591,RNA polymerase II, holoenzyme	GO:0042802,identical protein binding;GO:0000993,RNA polymerase II complex binding	GO:0070940,dephosphorylation of RNA polymerase II C-terminal domain;GO:0031124,mRNA 3'-end processing;GO:0042795,snRNA transcription by RNA polymerase II	
GLO2_HUMAN	Q16775	HAGH	Hydroxyacylglutathione hydrolase, mitochondrial	0.761754035	0.598294452	0.24822802	0.881191723	0.6800242435	0.5647098715	0.6800242435	0.5647098715	1.20420109125009	0.372792	0	0.830426086860534	0.372471	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005759,mitochondrial matrix	GO:0004416,hydroxyacylglutathione hydrolase activity;GO:0046872,metal ion binding;GO:0016787,hydrolase activity	GO:0006750,glutathione biosynthetic process;GO:0019243,methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione;GO:0006090,pyruvate metabolic process	hsa:3029,path:hsa00620,Pyruvate metabolism
SPRE_HUMAN	P35270	SPR	Sepiapterin reductase	0.922943341	1.034742402	0.906010224	0.54864096	0.9788428715	0.727325592	0.9788428715	0.727325592	1.34581112264781	0.337909	0	0.743046318440702	0.337522	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm	GO:0004033,aldo-keto reductase (NADP) activity;GO:0050661,NADP binding;GO:0004757,sepiapterin reductase activity	GO:0006809,nitric oxide biosynthetic process;GO:0050999,regulation of nitric-oxide synthase activity;GO:0006729,tetrahydrobiopterin biosynthetic process;GO:0046146,tetrahydrobiopterin metabolic process	hsa:6697,path:hsa00790,Folate biosynthesis
ABCF1_HUMAN	Q8NE71	ABCF1	ATP-binding cassette sub-family F member 1	0.503363678	0.2804954	0.892067366	0.46976816	0.391929539	0.680917763	0.391929539	0.680917763	0.575590123061601	0.294670	0	1.73734739345584	0.294962	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0005654,nucleoplasm;GO:0042788,polysomal ribosome;GO:0005840,ribosome	GO:0005524,ATP binding;GO:0042626,ATPase-coupled transmembrane transporter activity;GO:0043022,ribosome binding;GO:0003723,RNA binding;GO:0008494,translation activator activity;GO:0008135,translation factor activity, RNA binding	GO:0006954,inflammatory response;GO:0045727,positive regulation of translation;GO:0006412,translation;GO:0006413,translational initiation;GO:0055085,transmembrane transport	
CO6A6_HUMAN	A6NMZ7	COL6A6	Collagen alpha-6(VI) chain	0.637115885	2.207323822	5.063144149	44.71608807	1.4222198535	24.8896161095	1.4222198535	24.8896161095	0.0571410923833879	0.000024	-1	17.5005404742791	0.000024	1	GO:0005581,collagen trimer;GO:0062023,collagen-containing extracellular matrix;GO:0031012,extracellular matrix;GO:0005576,extracellular region		GO:0007155,cell adhesion	hsa:131873,path:hsa04151,PI3K-Akt signaling pathway;hsa:131873,path:hsa04512,ECM-receptor interaction;hsa:131873,path:hsa04510,Focal adhesion;hsa:131873,path:hsa04974,Protein digestion and absorption;hsa:131873,path:hsa05165,Human papillomavirus infection
CBPD_HUMAN	O75976	CPD	Carboxypeptidase D	0.46651223	0.769171117	0.384668031	0.284242977	0.6178416735	0.334455504	0.6178416735	0.334455504	1.84730604254012	0.246629	0	0.541328819898712	0.246107	0	GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0004181,metallocarboxypeptidase activity;GO:0004185,serine-type carboxypeptidase activity;GO:0008270,zinc ion binding	GO:0006518,peptide metabolic process;GO:0016485,protein processing	
SNUT2_HUMAN	Q53GS9	USP39	U4/U6.U5 tri-snRNP-associated protein 2	1.037489956	0.447351209	1.520667794	1.852751576	0.7424205825	1.686709685	0.7424205825	1.686709685	0.440159079598811	0.171119	0	2.2719058775556	0.171454	0	GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0046540,U4/U6 x U5 tri-snRNP complex	GO:0008270,zinc ion binding;GO:0004843,thiol-dependent deubiquitinase	GO:0007049,cell cycle;GO:0051301,cell division;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0016579,protein deubiquitination;GO:0008380,RNA splicing;GO:0000245,spliceosomal complex assembly	hsa:10713,path:hsa03040,Spliceosome
K2C74_HUMAN	Q7RTS7	KRT74	Keratin, type II cytoskeletal 74	0.940782835	0.345522959	0.853871077	1.389439829	0.643152897	1.121655453	0.643152897	1.121655453	0.573396130941825	0.292660	0	1.74399502549391	0.292954	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0045095,keratin filament	GO:1990254,keratin filament binding	GO:0070268,cornification;GO:0045104,intermediate filament cytoskeleton organization;GO:0031424,keratinization	
VATL_HUMAN	P27449	ATP6V0C	V-type proton ATPase 16 kDa proteolipid subunit	1.123662672	2.326251687	0.759084945	2.413382616	1.7249571795	1.5862337805	1.7249571795	1.5862337805	1.08745457366081	0.405741	0	0.919578641923036	0.405486	0	GO:0035577,azurophil granule membrane;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0101003,ficolin-1-rich granule membrane;GO:0005925,focal adhesion;GO:0016021,integral component of membrane;GO:0005765,lysosomal membrane;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0033179,proton-transporting V-type ATPase, V0 domain;GO:0070821,tertiary granule membrane;GO:0005774,vacuolar membrane	GO:0046933,proton-transporting ATP synthase activity, rotational mechanism;GO:0046961,proton-transporting ATPase activity, rotational mechanism;GO:0031625,ubiquitin protein ligase binding;GO:0015078,proton transmembrane transporter activity	GO:0034198,cellular response to amino acid starvation;GO:0008286,insulin receptor signaling pathway;GO:0034220,ion transmembrane transport;GO:0043312,neutrophil degranulation;GO:0090383,phagosome acidification;GO:0030177,positive regulation of Wnt signaling pathway;GO:1902600,proton transmembrane transport;GO:0016241,regulation of macroautophagy;GO:0033572,transferrin transport;GO:0016032,viral process	hsa:527,path:hsa00190,Oxidative phosphorylation;hsa:527,path:hsa04145,Phagosome;hsa:527,path:hsa04142,Lysosome;hsa:527,path:hsa04966,Collecting duct acid secretion;hsa:527,path:hsa04721,Synaptic vesicle cycle;hsa:527,path:hsa05323,Rheumatoid arthritis;hsa:527,path:hsa05110,Vibrio cholerae infection;hsa:527,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:527,path:hsa05152,Tuberculosis;hsa:527,path:hsa05165,Human papillomavirus infection
SURF4_HUMAN	O15260	SURF4	Surfeit locus protein 4	2.559517531	3.335874779	2.595547996	1.111935156	2.947696155	1.853741576	2.947696155	1.853741576	1.59013327055033	0.288155	0	0.628878106332503	0.287686	0	GO:0035577,azurophil granule membrane;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0005886,plasma membrane;GO:0030133,transport vesicle		GO:0007030,Golgi organization;GO:0043312,neutrophil degranulation;GO:0010638,positive regulation of organelle organization;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	
NCBP2_HUMAN	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.443316041	0.642704821	0.049557181	2.55E-05	0.543010431	0.0247913405	0.543010431	0.0247913405	21.9032299201409	0.002807	1	0.0456553669776557	0.002754	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005845,mRNA cap binding complex;GO:0005846,nuclear cap binding complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0034518,RNA cap binding complex	GO:0003729,mRNA binding;GO:0000340,RNA 7-methylguanosine cap binding;GO:0003723,RNA binding;GO:0000339,RNA cap binding;GO:0017069,snRNA binding	GO:0006370,7-methylguanosine mRNA capping;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0031047,gene silencing by RNA;GO:0008334,histone mRNA metabolic process;GO:0031124,mRNA 3'-end processing;GO:0045292,mRNA cis splicing, via spliceosome;GO:0006406,mRNA export from nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0051168,nuclear export;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0031442,positive regulation of mRNA 3'-end processing;GO:0046833,positive regulation of RNA export from nucleus;GO:0098789,pre-mRNA cleavage required for polyadenylation;GO:0006446,regulation of translational initiation;GO:0006405,RNA export from nucleus;GO:0016070,RNA metabolic process;GO:0008380,RNA splicing;GO:0006408,snRNA export from nucleus;GO:0042795,snRNA transcription by RNA polymerase II;GO:0006369,termination of RNA polymerase II transcription;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter	hsa:22916,path:hsa03040,Spliceosome;hsa:22916,path:hsa03013,RNA transport;hsa:22916,path:hsa03015,mRNA surveillance pathway
AGR2_HUMAN	O95994	AGR2	Anterior gradient protein 2 homolog	0.420359044	8.616814945	0.467459286	0.105966444	4.5185869945	0.286712865	4.5185869945	0.286712865	15.7599729419187	0.006351	1	0.0634518855892307	0.006250	-1	GO:0005783,endoplasmic reticulum;GO:0005615,extracellular space	GO:0002162,dystroglycan binding;GO:0005154,epidermal growth factor receptor binding;GO:0042802,identical protein binding	GO:0048546,digestive tract morphogenesis;GO:0070254,mucus secretion;GO:0060548,negative regulation of cell death;GO:0010811,positive regulation of cell-substrate adhesion;GO:0048639,positive regulation of developmental growth;GO:0045742,positive regulation of epidermal growth factor receptor signaling pathway;GO:0010628,positive regulation of gene expression;GO:1903896,positive regulation of IRE1-mediated unfolded protein response;GO:1903899,positive regulation of PERK-mediated unfolded protein response;GO:1903078,positive regulation of protein localization to plasma membrane;GO:0060480,lung goblet cell differentiation	
ADH1B_HUMAN	P00325	ADH1B	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	0.85724309	8.927508763	25.73521585	124.2605574	4.8923759265	74.997886625	4.8923759265	74.997886625	0.0652335171917919	0.000055	-1	15.3295428952561	0.000056	1	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0004024,alcohol dehydrogenase activity, zinc-dependent;GO:0004745,retinol dehydrogenase activity;GO:0008270,zinc ion binding;GO:0016491,oxidoreductase activity	GO:0006069,ethanol oxidation;GO:0042573,retinoic acid metabolic process;GO:0001523,retinoid metabolic process;GO:0042572,retinol metabolic process	hsa:125,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:125,path:hsa00071,Fatty acid degradation;hsa:125,path:hsa00350,Tyrosine metabolism;hsa:125,path:hsa00830,Retinol metabolism;hsa:125,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:125,path:hsa00982,Drug metabolism - cytochrome P450;hsa:125,path:hsa05204,Chemical carcinogenesis
VP33A_HUMAN	Q96AX1	VPS33A	Vacuolar protein sorting-associated protein 33A	0.297190334	0.277277628	0.307554638	0.33897642	0.287233981	0.323265529	0.287233981	0.323265529	0.888538848817376	0.472797	0	1.12544319399312	0.472686	0	GO:0005776,autophagosome;GO:0030136,clathrin-coated vesicle;GO:0033263,CORVET complex;GO:0005769,early endosome;GO:0030897,HOPS complex;GO:0005770,late endosome;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0048471,perinuclear region of cytoplasm		GO:0097352,autophagosome maturation;GO:0008333,endosome to lysosome transport;GO:0006886,intracellular protein transport;GO:0032418,lysosome localization;GO:0032400,melanosome localization;GO:0030220,platelet formation;GO:0048070,regulation of developmental pigmentation;GO:0035751,regulation of lysosomal lumen pH;GO:0016192,vesicle-mediated transport;GO:0015031,protein transport	hsa:65082,path:hsa05132,Salmonella infection
WASC4_HUMAN	Q2M389	WASHC4	WASH complex subunit 4	5.687161927	4.656737914	3.300887387	4.357367507	5.1719499205	3.829127447	5.1719499205	3.829127447	1.35068628351664	0.336796	0	0.740364370471286	0.336407	0	GO:0005769,early endosome;GO:0005768,endosome;GO:0005654,nucleoplasm;GO:0071203,WASH complex		GO:0016197,endosomal transport;GO:0007032,endosome organization;GO:0140591,nuclear envelope budding;GO:0015031,protein transport	hsa:23325,path:hsa04144,Endocytosis
BT3A1_HUMAN	O00481	BTN3A1	Butyrophilin subfamily 3 member A1	0.087682634	0.044056137	0.173242374	0.229265346	0.0658693855	0.20125386	0.0658693855	0.20125386	0.327295016850857	0.080379	0	3.05534746487046	0.080654	0	GO:0009897,external side of plasma membrane;GO:0016021,integral component of membrane;GO:0005886,plasma membrane	GO:0005102,signaling receptor binding	GO:0050798,activated T cell proliferation;GO:0002250,adaptive immune response;GO:0001819,positive regulation of cytokine production;GO:0032729,positive regulation of interferon-gamma production;GO:0001817,regulation of cytokine production;GO:0050852,T cell receptor signaling pathway	
PRS6A_HUMAN	P17980	PSMC3	26S proteasome regulatory subunit 6A	1.372925432	0.712906744	2.367942502	1.371088207	1.042916088	1.8695153545	1.042916088	1.8695153545	0.55785371619958	0.278392	0	1.79258463457513	0.278695	0	GO:0005829,cytosol;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body;GO:0022624,proteasome accessory complex;GO:0000502,proteasome complex;GO:0008540,proteasome regulatory particle, base subcomplex;GO:0034774,secretory granule lumen;GO:0005737,cytoplasm	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0042802,identical protein binding;GO:0036402,proteasome-activating ATPase activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0043921,modulation by host of viral transcription;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0043312,neutrophil degranulation;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0045899,positive regulation of RNA polymerase II transcription preinitiation complex assembly;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0030163,protein catabolic process	hsa:5702,path:hsa03050,Proteasome;hsa:5702,path:hsa05169,Epstein-Barr virus infection
CISD1_HUMAN	Q9NZ45	CISD1	CDGSH iron-sulfur domain-containing protein 1	1.483241029	3.475933205	0.618221456	0.710051313	2.479587117	0.6641363845	2.479587117	0.6641363845	3.733551082082	0.100589	0	0.26784152085107	0.100065	0	GO:0032473,cytoplasmic side of mitochondrial outer membrane;GO:0016021,integral component of membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion	GO:0051537,2 iron, 2 sulfur cluster binding;GO:0042802,identical protein binding;GO:0046872,metal ion binding	GO:0043457,regulation of cellular respiration	
NSMA3_HUMAN	Q9NXE4	SMPD4	Sphingomyelin phosphodiesterase 4	0.064248378	0.040947109	0.096851506	0.091409007	0.0525977435	0.0941302565	0.0525977435	0.0941302565	0.558776162476515	0.279240	0	1.78962537622931	0.279542	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0005635,nuclear envelope;GO:0005640,nuclear outer membrane;GO:0042383,sarcolemma;GO:0005802,trans-Golgi network	GO:0046872,metal ion binding;GO:0004767,sphingomyelin phosphodiesterase activity;GO:0050290,sphingomyelin phosphodiesterase D activity	GO:0071356,cellular response to tumor necrosis factor;GO:0046513,ceramide biosynthetic process;GO:0007029,endoplasmic reticulum organization;GO:0046475,glycerophospholipid catabolic process;GO:0006687,glycosphingolipid metabolic process;GO:0006685,sphingomyelin catabolic process	hsa:55627,path:hsa00600,Sphingolipid metabolism
SQOR_HUMAN	Q9Y6N5	SQOR	Sulfide:quinone oxidoreductase, mitochondrial	7.086479803	10.18763988	14.12587818	9.19739682	8.6370598415	11.6616375	8.6370598415	11.6616375	0.74063868316092	0.438606	0	1.35018602556941	0.438765	0	GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion	GO:0071949,FAD binding;GO:0048038,quinone binding;GO:0070224,sulfide;GO:0016491,oxidoreductase activity	GO:0070813,hydrogen sulfide metabolic process;GO:0070221,sulfide oxidation, using sulfide	hsa:58472,path:hsa00920,Sulfur metabolism
KVD33_HUMAN	P01593	IGKV1D-33	Immunoglobulin kappa variable 1D-33	0.202365228	0.104167005	0.403332217	0.303494772	0.1532661165	0.3534134945	0.1532661165	0.3534134945	0.433673639759672	0.165416	0	2.30588144705813	0.165751	0	GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane	GO:0003823,antigen binding	GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
RAB43_HUMAN	Q86YS6	RAB43	Ras-related protein Rab-43	1.824564611	9.467014435	0.428028212	0.353511878	5.645789523	0.390770045	5.645789523	0.390770045	14.4478564701652	0.007787	1	0.0692144195967753	0.007669	-1	GO:0012505,endomembrane system;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0045335,phagocytic vesicle;GO:0030670,phagocytic vesicle membrane;GO:0032588,trans-Golgi network membrane	GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0000045,autophagosome assembly;GO:0071346,cellular response to interferon-gamma;GO:0007030,Golgi organization;GO:0006886,intracellular protein transport;GO:0090382,phagosome maturation;GO:0035526,retrograde transport, plasma membrane to Golgi;GO:1901998,toxin transport;GO:0019068,virion assembly	
NMT2_HUMAN	O60551	NMT2	Glycylpeptide N-tetradecanoyltransferase 2	0.015250136	0.005732736	0.023581516	2.55E-05	0.010491436	0.011803508	0.010491436	0.011803508	0.88884050402643	0.472683	0	1.12506124042505	0.472572	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0019898,extrinsic component of membrane;GO:0005794,Golgi apparatus;GO:0043657,host cell;GO:0005886,plasma membrane	GO:0004379,glycylpeptide N-tetradecanoyltransferase activity	GO:0075733,intracellular transport of virus;GO:0018008,N-terminal peptidyl-glycine N-myristoylation;GO:0022400,regulation of rhodopsin mediated signaling pathway;GO:0006499,N-terminal protein myristoylation	
ACOT2_HUMAN	P49753	ACOT2	Acyl-coenzyme A thioesterase 2, mitochondrial	0.658271033	0.86235871	0.934595445	0.748096374	0.7603148715	0.8413459095	0.7603148715	0.8413459095	0.903688795434739	0.467128	0	1.10657563206693	0.467005	0	GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005782,peroxisomal matrix	GO:0047617,acyl-CoA hydrolase activity;GO:0052689,carboxylic ester hydrolase activity;GO:0102991,myristoyl-CoA hydrolase activity;GO:0016290,palmitoyl-CoA hydrolase activity;GO:0016790,thiolester hydrolase activity	GO:0006637,acyl-CoA metabolic process;GO:0006631,fatty acid metabolic process;GO:0001676,long-chain fatty acid metabolic process;GO:0008104,protein localization;GO:0000038,very long-chain fatty acid metabolic process	hsa:10965,path:hsa00062,Fatty acid elongation;hsa:10965,path:hsa01040,Biosynthesis of unsaturated fatty acids;hsa:10965,path:hsa04913,Ovarian steroidogenesis
TNPO1_HUMAN	Q92973	TNPO1	Transportin-1	1.886645367	0.985592516	2.56284549	2.27593807	1.4361189415	2.41939178	1.4361189415	2.41939178	0.593586765637436	0.311097	0	1.68467367854155	0.311377	0	GO:0005929,cilium;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0061608,nuclear import signal receptor activity;GO:0008139,nuclear localization sequence binding;GO:0003723,RNA binding;GO:0031267,small GTPase binding	GO:0035735,intraciliary transport involved in cilium assembly;GO:0006606,protein import into nucleus;GO:0043488,regulation of mRNA stability;GO:0016032,viral process	
F262_HUMAN	O60825	PFKFB2	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2	0.54270799	0.392724684	0.474941987	1.490456945	0.467716337	0.982699466	0.467716337	0.982699466	0.475950535420358	0.203190	0	2.10105867223535	0.203524	0	GO:0005829,cytosol;GO:0005654,nucleoplasm	GO:0003873,6-phosphofructo-2-kinase activity;GO:0005524,ATP binding;GO:0004331,fructose-2,6-bisphosphate 2-phosphatase activity;GO:0019901,protein kinase binding;GO:0003824,catalytic activity	GO:0006003,fructose 2,6-bisphosphate metabolic process;GO:0006000,fructose metabolic process;GO:0006007,glucose catabolic process;GO:0006096,glycolytic process;GO:0006089,lactate metabolic process;GO:0033133,positive regulation of glucokinase activity;GO:0045821,positive regulation of glycolytic process;GO:0032024,positive regulation of insulin secretion;GO:0009749,response to glucose	hsa:5208,path:hsa00051,Fructose and mannose metabolism;hsa:5208,path:hsa04152,AMPK signaling pathway;hsa:5208,path:hsa04919,Thyroid hormone signaling pathway
DHX29_HUMAN	Q7Z478	DHX29	ATP-dependent RNA helicase DHX29	0.278488486	0.042873002	0.28325183	2.55E-05	0.160680744	0.141638665	0.160680744	0.141638665	1.13444124879319	0.391978	0	0.881491219632391	0.391694	0	GO:0022627,cytosolic small ribosomal subunit;GO:0016282,eukaryotic 43S preinitiation complex;GO:0005737,cytoplasm	GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0017111,nucleoside-triphosphatase activity;GO:0043024,ribosomal small subunit binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0008494,translation activator activity;GO:0003743,translation initiation factor activity;GO:0016818,hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO:0001731,formation of translation preinitiation complex;GO:0045948,positive regulation of translational initiation;GO:0042255,ribosome assembly	
KRT85_HUMAN	P78386	KRT85	Keratin, type II cuticular Hb5	1.804512949	4.807543844	1.921605497	2.218464002	3.3060283965	2.0700347495	3.3060283965	2.0700347495	1.59708835675273	0.286901	0	0.626139434159576	0.286430	0	GO:0005829,cytosol;GO:0005615,extracellular space;GO:0045095,keratin filament;GO:0005882,intermediate filament	GO:0005198,structural molecule activity	GO:0070268,cornification;GO:0008544,epidermis development;GO:0031424,keratinization	
TRY1_HUMAN	P07477	PRSS1	Trypsin-1	36.89760804	15.09798028	27.09636255	84.88132078	25.99779416	55.988841665	25.99779416	55.988841665	0.464338846578636	0.192690	0	2.15359969851381	0.193025	0	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0046872,metal ion binding;GO:0004252,serine-type endopeptidase activity	GO:0009235,cobalamin metabolic process;GO:0007586,digestion;GO:0022617,extracellular matrix disassembly;GO:0006508,proteolysis	hsa:5644,path:hsa04080,Neuroactive ligand-receptor interaction;hsa:5644,path:hsa04972,Pancreatic secretion;hsa:5644,path:hsa04974,Protein digestion and absorption;hsa:5644,path:hsa05164,Influenza A
K1C18_HUMAN	P05783	KRT18	Keratin, type I cytoskeletal 18	144.3277413	33.59598935	68.59853416	31.82917734	88.961865325	50.21385575	88.961865325	50.21385575	1.77165971416166	0.257880	0	0.564442478432261	0.257371	0	GO:0005912,adherens junction;GO:0034451,centriolar satellite;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005882,intermediate filament;GO:0045095,keratin filament;GO:0005815,microtubule organizing center;GO:0005730,nucleolus;GO:0048471,perinuclear region of cytoplasm;GO:0032991,protein-containing complex	GO:0098641,cadherin binding involved in cell-cell adhesion;GO:0003723,RNA binding;GO:0097110,scaffold protein binding;GO:0005198,structural molecule activity	GO:0009653,anatomical structure morphogenesis;GO:0007049,cell cycle;GO:1902488,cholangiocyte apoptotic process;GO:0070268,cornification;GO:0097191,extrinsic apoptotic signaling pathway;GO:0043000,Golgi to plasma membrane CFTR protein transport;GO:0097284,hepatocyte apoptotic process;GO:0070365,hepatocyte differentiation;GO:0045104,intermediate filament cytoskeleton organization;GO:0031424,keratinization;GO:0072497,mesenchymal stem cell differentiation;GO:0043066,negative regulation of apoptotic process;GO:0009750,response to fructose;GO:0031667,response to nutrient levels;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process	hsa:3875,path:hsa04915,Estrogen signaling pathway;hsa:3875,path:hsa05150,Staphylococcus aureus infection
LXN_HUMAN	Q9BS40	LXN	Latexin	2.262278578	1.440941707	3.138063027	3.063921528	1.8516101425	3.1009922775	1.8516101425	3.1009922775	0.59710246811474	0.314293	0	1.67475442390541	0.314570	0	GO:0005737,cytoplasm;GO:0005615,extracellular space	GO:0004857,enzyme inhibitor activity;GO:0008201,heparin binding;GO:0008191,metalloendopeptidase inhibitor activity	GO:0050965,detection of temperature stimulus involved in sensory perception of pain;GO:0006954,inflammatory response	
CBPA3_HUMAN	P15088	CPA3	Mast cell carboxypeptidase A	0.043643437	0.400258312	0.398522726	1.614074146	0.2219508745	1.006298436	0.2219508745	1.006298436	0.220561680868994	0.022445	-1	4.53387912197661	0.022580	1	GO:0062023,collagen-containing extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0030141,secretory granule;GO:0030133,transport vesicle	GO:0004181,metallocarboxypeptidase activity;GO:0008270,zinc ion binding	GO:0002003,angiotensin maturation;GO:0006508,proteolysis	hsa:1359,path:hsa04614,Renin-angiotensin system;hsa:1359,path:hsa04972,Pancreatic secretion;hsa:1359,path:hsa04974,Protein digestion and absorption
RRAS_HUMAN	P10301	RRAS	Ras-related protein R-Ras	3.297476849	3.827185101	0.366547965	1.044429755	3.562330975	0.70548886	3.562330975	0.70548886	5.04945035560165	0.062677	0	0.198041356895537	0.062241	0	GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005886,plasma membrane	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0044877,protein-containing complex binding	GO:0060325,face morphogenesis;GO:0002521,leukocyte differentiation;GO:0030336,negative regulation of cell migration;GO:0045766,positive regulation of angiogenesis;GO:0010595,positive regulation of endothelial cell migration;GO:1904906,positive regulation of endothelial cell-matrix adhesion via fibronectin;GO:2001214,positive regulation of vasculogenesis;GO:0007265,Ras protein signal transduction;GO:0070372,regulation of ERK1 and ERK2 cascade;GO:0051896,regulation of protein kinase B signaling	hsa:6237,path:hsa04014,Ras signaling pathway;hsa:6237,path:hsa04015,Rap1 signaling pathway;hsa:6237,path:hsa04010,MAPK signaling pathway;hsa:6237,path:hsa04371,Apelin signaling pathway;hsa:6237,path:hsa04072,Phospholipase D signaling pathway;hsa:6237,path:hsa04024,cAMP signaling pathway;hsa:6237,path:hsa04140,Autophagy - animal;hsa:6237,path:hsa04137,Mitophagy - animal;hsa:6237,path:hsa04218,Cellular senescence;hsa:6237,path:hsa04810,Regulation of actin cytoskeleton;hsa:6237,path:hsa04625,C-type lectin receptor signaling pathway;hsa:6237,path:hsa04360,Axon guidance;hsa:6237,path:hsa05205,Proteoglycans in cancer;hsa:6237,path:hsa05132,Salmonella infection
FCHO2_HUMAN	Q0JRZ9	FCHO2	F-BAR domain only protein 2	0.179365361	0.319124898	0.251711743	0.278085997	0.2492451295	0.26489887	0.2492451295	0.26489887	0.940906729802207	0.453625	0	1.06280459935728	0.453472	0	GO:0005905,clathrin-coated pit;GO:0030136,clathrin-coated vesicle;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005886,plasma membrane;GO:0098835,presynaptic endocytic zone membrane	GO:0042802,identical protein binding;GO:0035091,phosphatidylinositol binding;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding;GO:0001786,phosphatidylserine binding	GO:0048268,clathrin coat assembly;GO:0072583,clathrin-dependent endocytosis;GO:0010324,membrane invagination;GO:0061024,membrane organization;GO:0072659,protein localization to plasma membrane;GO:0048488,synaptic vesicle endocytosis	
SPB6_HUMAN	P35237	SERPINB6	Serpin B6	4.150936785	5.668044529	6.762471623	14.22375993	4.909490657	10.4931157765	4.909490657	10.4931157765	0.467877297989518	0.195881	0	2.13731250543044	0.196216	0	GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0101003,ficolin-1-rich granule membrane;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0097180,serine protease inhibitor complex;GO:0070821,tertiary granule membrane;GO:0016021,integral component of membrane	GO:0002020,protease binding;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0071470,cellular response to osmotic stress;GO:0010951,negative regulation of endopeptidase activity;GO:0043312,neutrophil degranulation;GO:0007605,sensory perception of sound	hsa:5269,path:hsa05146,Amoebiasis
RB27A_HUMAN	P51159	RAB27A	Ras-related protein Rab-27A	1.220959513	0.561406177	0.932371511	0.564241755	0.891182845	0.748306633	0.891182845	0.748306633	1.19093270819637	0.376332	0	0.839678004573798	0.376018	0	GO:0016324,apical plasma membrane;GO:0005829,cytosol;GO:0030425,dendrite;GO:0070382,exocytic vesicle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005794,Golgi apparatus;GO:0005770,late endosome;GO:0005764,lysosome;GO:0042470,melanosome;GO:0033162,melanosome membrane;GO:0032585,multivesicular body membrane;GO:0001750,photoreceptor outer segment;GO:0030141,secretory granule;GO:0030667,secretory granule membrane;GO:0035580,specific granule lumen;GO:0033093,Weibel-Palade body;GO:0016020,membrane	GO:0003925,G protein activity;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0031489,myosin V binding;GO:0019904,protein domain specific binding	GO:0019882,antigen processing and presentation;GO:0007596,blood coagulation;GO:0097278,complement-dependent cytotoxicity;GO:0043316,cytotoxic T cell degranulation;GO:0006887,exocytosis;GO:1990182,exosomal secretion;GO:0030318,melanocyte differentiation;GO:0032400,melanosome localization;GO:0032402,melanosome transport;GO:0036257,multivesicular body organization;GO:0071985,multivesicular body sorting pathway;GO:0043320,natural killer cell degranulation;GO:0043312,neutrophil degranulation;GO:1903435,positive regulation of constitutive secretory pathway;GO:0045921,positive regulation of exocytosis;GO:0010628,positive regulation of gene expression;GO:0050766,positive regulation of phagocytosis;GO:1903428,positive regulation of reactive oxygen species biosynthetic process;GO:1903307,positive regulation of regulated secretory pathway;GO:0006605,protein targeting;GO:0048489,synaptic vesicle transport	
CPVL_HUMAN	Q9H3G5	CPVL	Probable serine carboxypeptidase CPVL	0.745575551	1.166680523	1.514414809	1.59027877	0.956128037	1.5523467895	0.956128037	1.5523467895	0.615924253180542	0.331313	0	1.62357626743248	0.331577	0	GO:0070062,extracellular exosome	GO:0004185,serine-type carboxypeptidase activity		
GBB1_HUMAN	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.682613666	0.614526164	0.78422371	1.370837261	0.648569915	1.0775304855	0.648569915	1.0775304855	0.601904005248676	0.318649	0	1.66139449360675	0.318924	0	GO:0044297,cell body;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:1903561,extracellular vesicle;GO:0005834,heterotrimeric G-protein complex;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0097381,photoreceptor disc membrane;GO:0001917,photoreceptor inner segment;GO:0042622,photoreceptor outer segment membrane;GO:0005886,plasma membrane;GO:0045202,synapse	GO:0047391,alkylglycerophosphoethanolamine phosphodiesterase activity;GO:0031682,G-protein gamma-subunit binding;GO:0003924,GTPase activity;GO:0051020,GTPase binding;GO:0044877,protein-containing complex binding;GO:0030507,spectrin binding	GO:0007191,adenylate cyclase-activating dopamine receptor signaling pathway;GO:0010659,cardiac muscle cell apoptotic process;GO:0008283,cell population proliferation;GO:0071870,cellular response to catecholamine stimulus;GO:0071456,cellular response to hypoxia;GO:0071380,cellular response to prostaglandin E stimulus;GO:0007213,G protein-coupled acetylcholine receptor signaling pathway;GO:0007186,G protein-coupled receptor signaling pathway;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0007200,phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0030168,platelet activation;GO:0007204,positive regulation of cytosolic calcium ion concentration;GO:1901381,positive regulation of potassium ion transmembrane transport;GO:0006457,protein folding;GO:0007265,Ras protein signal transduction;GO:0060041,retina development in camera-type eye;GO:0016056,rhodopsin mediated signaling pathway;GO:0050909,sensory perception of taste;GO:0007165,signal transduction;GO:0007223,Wnt signaling pathway, calcium modulating pathway	hsa:2782,path:hsa04014,Ras signaling pathway;hsa:2782,path:hsa04371,Apelin signaling pathway;hsa:2782,path:hsa04151,PI3K-Akt signaling pathway;hsa:2782,path:hsa04062,Chemokine signaling pathway;hsa:2782,path:hsa04926,Relaxin signaling pathway;hsa:2782,path:hsa04724,Glutamatergic synapse;hsa:2782,path:hsa04727,GABAergic synapse;hsa:2782,path:hsa04725,Cholinergic synapse;hsa:2782,path:hsa04728,Dopaminergic synapse;hsa:2782,path:hsa04726,Serotonergic synapse;hsa:2782,path:hsa04723,Retrograde endocannabinoid signaling;hsa:2782,path:hsa04744,Phototransduction;hsa:2782,path:hsa04740,Olfactory transduction;hsa:2782,path:hsa04713,Circadian entrainment;hsa:2782,path:hsa05200,Pathways in cancer;hsa:2782,path:hsa05032,Morphine addiction;hsa:2782,path:hsa05034,Alcoholism;hsa:2782,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:2782,path:hsa05163,Human cytomegalovirus infection;hsa:2782,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection
GBP5_HUMAN	Q96PP8	GBP5	Guanylate-binding protein 5	0.775841919	0.119049846	0.395327897	0.134650972	0.4474458825	0.2649894345	0.4474458825	0.2649894345	1.6885423501668	0.271131	0	0.592226780631957	0.270639	0	GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity	GO:0071346,cellular response to interferon-gamma;GO:0006954,inflammatory response;GO:1900017,positive regulation of cytokine production involved in inflammatory response;GO:0045089,positive regulation of innate immune response;GO:0032731,positive regulation of interleukin-1 beta production;GO:0032741,positive regulation of interleukin-18 production;GO:1900227,positive regulation of NLRP3 inflammasome complex assembly;GO:0051289,protein homotetramerization;GO:0034067,protein localization to Golgi apparatus	hsa:115362,path:hsa04621,NOD-like receptor signaling pathway
BMP2K_HUMAN	Q9NSY1	BMP2K	BMP-2-inducible protein kinase	0.063279017	2.814264949	0.049007071	0.108430669	1.438771983	0.07871887	1.438771983	0.07871887	18.2773454827286	0.004436	1	0.0547125402288293	0.004359	-1	GO:0005737,cytoplasm;GO:0016607,nuclear speck;GO:0005634,nucleus	GO:0035612,AP-2 adaptor complex binding;GO:0005524,ATP binding;GO:0019208,phosphatase regulator activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0004672,protein kinase activity	GO:0045747,positive regulation of Notch signaling pathway;GO:0006468,protein phosphorylation;GO:0030500,regulation of bone mineralization;GO:2000369,regulation of clathrin-dependent endocytosis	hsa:55589,path:hsa05202,Transcriptional misregulation in cancer
GPI8_HUMAN	Q92643	PIGK	GPI-anchor transamidase	0.220664197	0.316922236	0.357753086	0.252775848	0.2687932165	0.305264467	0.2687932165	0.305264467	0.880525726238554	0.475837	0	1.13568515967366	0.475733	0	GO:0005789,endoplasmic reticulum membrane;GO:0042765,GPI-anchor transamidase complex;GO:0016020,membrane	GO:0003923,GPI-anchor transamidase activity;GO:0003756,protein disulfide isomerase activity	GO:0016255,attachment of GPI anchor to protein;GO:0034394,protein localization to cell surface	hsa:10026,path:hsa00563,Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
RADI_HUMAN	P35241	RDX	Radixin	0.672994191	0.674018468	1.072747586	3.095610661	0.6735063295	2.0841791235	0.6735063295	2.0841791235	0.323151845206552	0.077514	0	3.09452047027867	0.077785	0	GO:0005912,adherens junction;GO:0016324,apical plasma membrane;GO:0071944,cell periphery;GO:0051286,cell tip;GO:0032154,cleavage furrow;GO:0030864,cortical actin cytoskeleton;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0030175,filopodium;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0005902,microvillus;GO:0030496,midbody;GO:0005886,plasma membrane;GO:0030315,T-tubule;GO:0005856,cytoskeleton;GO:0042995,cell projection;GO:0005737,cytoplasm	GO:0003779,actin binding;GO:0051117,ATPase binding;GO:0045296,cadherin binding;GO:0051018,protein kinase A binding;GO:0003723,RNA binding;GO:0008092,cytoskeletal protein binding	GO:0045176,apical protein localization;GO:0051016,barbed-end actin filament capping;GO:0036120,cellular response to platelet-derived growth factor stimulus;GO:0097067,cellular response to thyroid hormone stimulus;GO:0061028,establishment of endothelial barrier;GO:0045184,establishment of protein localization;GO:1903392,negative regulation of adherens junction organization;GO:0045792,negative regulation of cell size;GO:0034260,negative regulation of GTPase activity;GO:0034111,negative regulation of homotypic cell-cell adhesion;GO:0030335,positive regulation of cell migration;GO:1903364,positive regulation of cellular protein catabolic process;GO:2000643,positive regulation of early endosome to late endosome transport;GO:1900087,positive regulation of G1/S transition of mitotic cell cycle;GO:0010628,positive regulation of gene expression;GO:1902966,positive regulation of protein localization to early endosome;GO:0010737,protein kinase A signaling;GO:0072659,protein localization to plasma membrane;GO:0032231,regulation of actin filament bundle assembly;GO:0008360,regulation of cell shape;GO:0008361,regulation of cell size;GO:0043087,regulation of GTPase activity;GO:1902115,regulation of organelle assembly;GO:0032487,regulation of Rap protein signal transduction;GO:1900027,regulation of ruffle assembly	hsa:5962,path:hsa04530,Tight junction;hsa:5962,path:hsa04810,Regulation of actin cytoskeleton;hsa:5962,path:hsa05206,MicroRNAs in cancer;hsa:5962,path:hsa05205,Proteoglycans in cancer
SYPL1_HUMAN	Q16563	SYPL1	Synaptophysin-like protein 1	0.795824005	1.214758082	1.440790584	3.132453767	1.0052910435	2.2866221755	1.0052910435	2.2866221755	0.439640205658453	0.170661	0	2.27458723549246	0.170996	0	GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0030285,integral component of synaptic vesicle membrane;GO:0042470,melanosome;GO:0030141,secretory granule;GO:0030672,synaptic vesicle membrane;GO:0008021,synaptic vesicle	GO:0017075,syntaxin-1 binding	GO:0007268,chemical synaptic transmission	
RS11_HUMAN	P62280	RPS11	40S ribosomal protein S11	7.633943614	12.06712287	2.786900973	1.127624252	9.850533242	1.9572626125	9.850533242	1.9572626125	5.03281122271986	0.063021	0	0.198696107552306	0.062584	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0019843,rRNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6205,path:hsa03010,Ribosome
GCN1_HUMAN	Q92616	GCN1	eIF-2-alpha kinase activator GCN1	4.454756882	2.49587689	4.908450145	3.033769946	3.475316886	3.9711100455	3.475316886	3.9711100455	0.875149982292275	0.477892	0	1.14266128119058	0.477793	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005844,polysome;GO:0005840,ribosome	GO:0045296,cadherin binding;GO:0019901,protein kinase binding;GO:0019887,protein kinase regulator activity;GO:0043022,ribosome binding;GO:0003723,RNA binding;GO:0008135,translation factor activity, RNA binding	GO:0034198,cellular response to amino acid starvation;GO:1990253,cellular response to leucine starvation;GO:0033674,positive regulation of kinase activity;GO:0036003,positive regulation of transcription from RNA polymerase II promoter in response to stress	
F10A1_HUMAN	P50502	ST13	Hsc70-interacting protein	5.07792654	4.519233245	6.977821727	22.98264337	4.7985798925	14.9802325485	4.7985798925	14.9802325485	0.320327463339712	0.075585	0	3.12180538494598	0.075853	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0032991,protein-containing complex	GO:0051087,chaperone binding;GO:0032564,dATP binding;GO:0031072,heat shock protein binding;GO:0030544,Hsp70 protein binding;GO:0042802,identical protein binding;GO:0046983,protein dimerization activity;GO:0019904,protein domain specific binding;GO:0044877,protein-containing complex binding;GO:0030674,protein-macromolecule adaptor activity;GO:0051082,unfolded protein binding	GO:0051085,chaperone cofactor-dependent protein refolding;GO:0061084,negative regulation of protein refolding;GO:0006457,protein folding;GO:0065003,protein-containing complex assembly;GO:0009617,response to bacterium	
PWP2_HUMAN	Q15269	PWP2	Periodic tryptophan protein 2 homolog	0.080580476	0.019943305	0.1293223	0.017876284	0.0502618905	0.073599292	0.0502618905	0.073599292	0.682912690247075	0.390309	0	1.46431603085045	0.390519	0	GO:0005654,nucleoplasm;GO:0034388,Pwp2p-containing subcomplex of 90S preribosome;GO:0032040,small-subunit processome	GO:0003723,RNA binding	GO:0000462,maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000028,ribosomal small subunit assembly;GO:0006364,rRNA processing	hsa:5822,path:hsa03008,Ribosome biogenesis in eukaryotes
PHS_HUMAN	P61457	PCBD1	Pterin-4-alpha-carbinolamine dehydratase	0.698826592	0.757048434	0.60802715	0.107364933	0.727937513	0.3576960415	0.727937513	0.3576960415	2.03507287904946	0.221621	0	0.491382893602847	0.221075	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm	GO:0008124,4-alpha-hydroxytetrahydrobiopterin dehydratase activity;GO:0042802,identical protein binding;GO:0004505,phenylalanine 4-monooxygenase activity;GO:0003713,transcription coactivator activity	GO:0006558,L-phenylalanine metabolic process;GO:0043393,regulation of protein binding;GO:0006729,tetrahydrobiopterin biosynthetic process	hsa:5092,path:hsa00790,Folate biosynthesis
NID2_HUMAN	Q14112	NID2	Nidogen-2	3.089826382	1.952696431	3.277833954	6.8195737	2.5212614065	5.048703827	2.5212614065	5.048703827	0.499387861299474	0.224579	0	2.00245155618694	0.224907	0	GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane	GO:0005509,calcium ion binding;GO:0005518,collagen binding;GO:0005201,extracellular matrix structural constituent	GO:0071711,basement membrane organization;GO:0007155,cell adhesion;GO:0007160,cell-matrix adhesion;GO:0030198,extracellular matrix organization	
DSG1_HUMAN	Q02413	DSG1	Desmoglein-1	2.384499165	1.480678199	1.422774315	2.558072704	1.932588682	1.9904235095	1.932588682	1.9904235095	0.970943456393093	0.443147	0	1.02992609241618	0.442971	0	GO:0016324,apical plasma membrane;GO:0001533,cornified envelope;GO:0009898,cytoplasmic side of plasma membrane;GO:0005829,cytosol;GO:0030057,desmosome;GO:0101003,ficolin-1-rich granule membrane;GO:0016021,integral component of membrane;GO:0016328,lateral plasma membrane;GO:0005886,plasma membrane	GO:0005509,calcium ion binding;GO:0045295,gamma-catenin binding;GO:0015643,toxic substance binding	GO:0016339,calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0098609,cell-cell adhesion;GO:0007043,cell-cell junction assembly;GO:0070268,cornification;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0031424,keratinization;GO:0060135,maternal process involved in female pregnancy;GO:0043312,neutrophil degranulation;GO:0050821,protein stabilization;GO:0032570,response to progesterone	hsa:1828,path:hsa05150,Staphylococcus aureus infection
PPM1A_HUMAN	P35813	PPM1A	Protein phosphatase 1A	0.239595348	0.259588937	0.311964861	0.327895061	0.2495921425	0.319929961	0.2495921425	0.319929961	0.780146197373493	0.470073	0	1.28181102896699	0.470198	0	GO:0005829,cytosol;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0033192,calmodulin-dependent protein phosphatase activity;GO:0000287,magnesium ion binding;GO:0030145,manganese ion binding;GO:0106306,protein serine phosphatase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0106307,protein threonine phosphatase activity;GO:0070412,R-SMAD binding;GO:0046872,metal ion binding;GO:0004721,phosphoprotein phosphatase activity	GO:0007050,cell cycle arrest;GO:0071560,cellular response to transforming growth factor beta stimulus;GO:0016311,dephosphorylation;GO:0006499,N-terminal protein myristoylation;GO:0030514,negative regulation of BMP signaling pathway;GO:0043124,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:1901223,negative regulation of NIK/NF-kappaB signaling;GO:0010991,negative regulation of SMAD protein complex assembly;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0035970,peptidyl-threonine dephosphorylation;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046827,positive regulation of protein export from nucleus;GO:0045893,positive regulation of transcription, DNA-templated;GO:0006470,protein dephosphorylation	hsa:5494,path:hsa04010,MAPK signaling pathway
ADK_HUMAN	P55263	ADK	Adenosine kinase	0.72581476	1.737778481	1.589483727	0.798799031	1.2317966205	1.194141379	1.2317966205	1.194141379	1.03153331938931	0.423082	0	0.969430634186417	0.422863	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0004001,adenosine kinase activity;GO:0005524,ATP binding;GO:0046872,metal ion binding;GO:0003723,RNA binding	GO:0044209,AMP salvage;GO:0006175,dATP biosynthetic process;GO:0006166,purine ribonucleoside salvage;GO:0043101,purine-containing compound salvage;GO:0009156,ribonucleoside monophosphate biosynthetic process	hsa:132,path:hsa00230,Purine metabolism
LAMC1_HUMAN	P11047	LAMC1	Laminin subunit gamma-1	2.697449784	2.415476317	6.229709031	24.2206068	2.5564630505	15.2251579155	2.5564630505	15.2251579155	0.167910445637965	0.007707	-1	5.9555556308636	0.007771	1	GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005606,laminin-1 complex;GO:0043259,laminin-10 complex;GO:0043260,laminin-11 complex	GO:0005201,extracellular matrix structural constituent	GO:0009887,animal organ morphogenesis;GO:0007155,cell adhesion;GO:0016477,cell migration;GO:0044267,cellular protein metabolic process;GO:0007492,endoderm development;GO:0022617,extracellular matrix disassembly;GO:0030198,extracellular matrix organization;GO:0031581,hemidesmosome assembly;GO:0035633,maintenance of blood-brain barrier;GO:0050679,positive regulation of epithelial cell proliferation;GO:0043687,post-translational protein modification;GO:0065003,protein-containing complex assembly;GO:0034446,substrate adhesion-dependent cell spreading;GO:0009888,tissue development	hsa:3915,path:hsa04151,PI3K-Akt signaling pathway;hsa:3915,path:hsa04512,ECM-receptor interaction;hsa:3915,path:hsa04510,Focal adhesion;hsa:3915,path:hsa05200,Pathways in cancer;hsa:3915,path:hsa05222,Small cell lung cancer;hsa:3915,path:hsa05020,Prion diseases;hsa:3915,path:hsa05165,Human papillomavirus infection;hsa:3915,path:hsa05146,Amoebiasis;hsa:3915,path:hsa05145,Toxoplasmosis
METK2_HUMAN	P31153	MAT2A	S-adenosylmethionine synthase isoform type-2	1.687541442	2.66943336	2.61255811	1.441991098	2.178487401	2.027274604	2.178487401	2.027274604	1.07458920301258	0.409635	0	0.930588170062132	0.409388	0	GO:0005829,cytosol;GO:0048269,methionine adenosyltransferase complex	GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0004478,methionine adenosyltransferase activity	GO:1990830,cellular response to leukemia inhibitory factor;GO:0032259,methylation;GO:0006730,one-carbon metabolic process;GO:0051291,protein heterooligomerization;GO:0034214,protein hexamerization;GO:0006556,S-adenosylmethionine biosynthetic process	hsa:4144,path:hsa00270,Cysteine and methionine metabolism
TETN_HUMAN	P05452	CLEC3B	Tetranectin	0.48960255	1.835617783	0.190623812	0.013836518	1.1626101665	0.102230165	1.1626101665	0.102230165	11.3724766706578	0.013311	1	0.0879315938787638	0.013139	-1	GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0001652,granular component;GO:0031089,platelet dense granule lumen	GO:0005509,calcium ion binding;GO:0030246,carbohydrate binding;GO:0008201,heparin binding;GO:0036143,kringle domain binding	GO:0030282,bone mineralization;GO:0071310,cellular response to organic substance;GO:0071560,cellular response to transforming growth factor beta stimulus;GO:0001503,ossification;GO:0002576,platelet degranulation;GO:0010756,positive regulation of plasminogen activation	
DNPEP_HUMAN	Q9ULA0	DNPEP	Aspartyl aminopeptidase	1.521801068	3.122589526	2.416669522	2.926476509	2.322195297	2.6715730155	2.322195297	2.6715730155	0.869223967874742	0.480174	0	1.15045147966295	0.480079	0	GO:0072562,blood microparticle;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus	GO:0004177,aminopeptidase activity;GO:0042802,identical protein binding;GO:0008237,metallopeptidase activity;GO:0008270,zinc ion binding	GO:0006518,peptide metabolic process	
EIF3E_HUMAN	P60228	EIF3E	Eukaryotic translation initiation factor 3 subunit E	5.441763818	4.027346791	6.419676236	4.110424427	4.7345553045	5.2650503315	4.7345553045	5.2650503315	0.899242173654803	0.468781	0	1.11204748764806	0.468662	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016282,eukaryotic 43S preinitiation complex;GO:0033290,eukaryotic 48S preinitiation complex;GO:0005852,eukaryotic translation initiation factor 3 complex;GO:0071540,eukaryotic translation initiation factor 3 complex, eIF3e;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016605,PML body	GO:0045296,cadherin binding;GO:0047485,protein N-terminus binding;GO:0003723,RNA binding;GO:0003743,translation initiation factor activity	GO:0001732,formation of cytoplasmic translation initiation complex;GO:0045947,negative regulation of translational initiation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:1902416,positive regulation of mRNA binding;GO:0045727,positive regulation of translation;GO:0006446,regulation of translational initiation;GO:0006413,translational initiation	hsa:3646,path:hsa03013,RNA transport;hsa:3646,path:hsa05160,Hepatitis C
SYSM_HUMAN	Q9NP81	SARS2	Serine--tRNA ligase, mitochondrial	0.338155977	0.112274073	0.520176712	0.525932004	0.225215025	0.523054358	0.225215025	0.523054358	0.430576710728792	0.162708	0	2.32246653170675	0.163042	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0003723,RNA binding;GO:0004828,serine-tRNA ligase activity;GO:0000049,tRNA binding;GO:0000166,nucleotide binding	GO:0070158,mitochondrial seryl-tRNA aminoacylation;GO:0097056,selenocysteinyl-tRNA(Sec) biosynthetic process;GO:0006434,seryl-tRNA aminoacylation;GO:0006418,tRNA aminoacylation for protein translation	hsa:54938,path:hsa00970,Aminoacyl-tRNA biosynthesis
RSU1_HUMAN	Q15404	RSU1	Ras suppressor protein 1	2.349039482	2.102501166	1.935796991	5.040672544	2.225770324	3.4882347675	2.225770324	3.4882347675	0.638079278590299	0.351125	0	1.56720337668587	0.351372	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion		GO:0010811,positive regulation of cell-substrate adhesion;GO:0043547,positive regulation of GTPase activity;GO:0007165,signal transduction	
ARBK1_HUMAN	P25098	GRK2	Beta-adrenergic receptor kinase 1	0.225198815	0.125543843	0.264152374	0.146258876	0.175371329	0.205205625	0.175371329	0.205205625	0.854612679355159	0.485869	0	1.17012071568438	0.485787	0	GO:0005929,cilium;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0045202,synapse	GO:0031694,alpha-2A adrenergic receptor binding;GO:0005524,ATP binding;GO:0047696,beta-adrenergic receptor kinase activity;GO:0031755,Edg-2 lysophosphatidic acid receptor binding;GO:0004703,G protein-coupled receptor kinase activity;GO:0004672,protein kinase activity	GO:0060048,cardiac muscle contraction;GO:0002029,desensitization of G protein-coupled receptor signaling pathway;GO:0007213,G protein-coupled acetylcholine receptor signaling pathway;GO:0007186,G protein-coupled receptor signaling pathway;GO:0007507,heart development;GO:1901081,negative regulation of relaxation of smooth muscle;GO:0045988,negative regulation of striated muscle contraction;GO:0003108,negative regulation of the force of heart contraction by chemical signal;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:0033605,positive regulation of catecholamine secretion;GO:0031623,receptor internalization;GO:0007217,tachykinin receptor signaling pathway;GO:0046718,viral entry into host cell;GO:0019079,viral genome replication;GO:0007165,signal transduction	hsa:156,path:hsa04340,Hedgehog signaling pathway;hsa:156,path:hsa04144,Endocytosis;hsa:156,path:hsa04062,Chemokine signaling pathway;hsa:156,path:hsa04724,Glutamatergic synapse;hsa:156,path:hsa04740,Olfactory transduction;hsa:156,path:hsa05032,Morphine addiction
ARPC5_HUMAN	O15511	ARPC5	Actin-related protein 2/3 complex subunit 5	3.911410937	21.1073708	0.652431446	0.145131351	12.5093908685	0.3987813985	12.5093908685	0.3987813985	31.3690430786229	0.001062	1	0.0318785624889358	0.001038	-1	GO:0015629,actin cytoskeleton;GO:0005885,Arp2/3 protein complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005925,focal adhesion;GO:0030426,growth cone;GO:0030027,lamellipodium;GO:0005634,nucleus;GO:0034774,secretory granule lumen;GO:0035861,site of double-strand break	GO:0003779,actin binding;GO:0005200,structural constituent of cytoskeleton	GO:0030036,actin cytoskeleton organization;GO:0051639,actin filament network formation;GO:0034314,Arp2/3 complex-mediated actin nucleation;GO:0016477,cell migration;GO:0048013,ephrin receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0097581,lamellipodium organization;GO:0030011,maintenance of cell polarity;GO:0061024,membrane organization;GO:0061842,microtubule organizing center localization;GO:0043312,neutrophil degranulation;GO:0021769,orbitofrontal cortex development;GO:0014909,smooth muscle cell migration	hsa:10092,path:hsa04144,Endocytosis;hsa:10092,path:hsa04810,Regulation of actin cytoskeleton;hsa:10092,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:10092,path:hsa05130,Pathogenic Escherichia coli infection;hsa:10092,path:hsa05132,Salmonella infection;hsa:10092,path:hsa05131,Shigellosis;hsa:10092,path:hsa05100,Bacterial invasion of epithelial cells
A1BG_HUMAN	P04217	A1BG	Alpha-1B-glycoprotein	3.139752996	2.007421435	3.430363125	14.65527367	2.5735872155	9.0428183975	2.5735872155	9.0428183975	0.284600121596106	0.053033	0	3.51370194219089	0.053258	0	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0031093,platelet alpha granule lumen;GO:0034774,secretory granule lumen		GO:0043312,neutrophil degranulation;GO:0002576,platelet degranulation	
EM55_HUMAN	Q00013	MPP1	55 kDa erythrocyte membrane protein	0.207531455	0.749704753	0.366932703	1.190167635	0.478618104	0.778550169	0.478618104	0.778550169	0.614755635612738	0.330261	0	1.6266625990395	0.330526	0	GO:0034451,centriolar satellite;GO:0030863,cortical cytoskeleton;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0032420,stereocilium	GO:0004385,guanylate kinase activity	GO:0090022,regulation of neutrophil chemotaxis;GO:0007165,signal transduction	
GLYG_HUMAN	P46976	GYG1	Glycogenin-1	2.145472833	1.292966123	3.738978671	6.652031689	1.719219478	5.19550518	1.719219478	5.19550518	0.330905160987637	0.082910	0	3.02201391182703	0.083188	0	GO:0005829,cytosol;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0043202,lysosomal lumen;GO:0016020,membrane;GO:0034774,secretory granule lumen	GO:0008466,glycogenin glucosyltransferase activity;GO:0030145,manganese ion binding;GO:0042803,protein homodimerization activity;GO:0016757,transferase activity, transferring glycosyl groups;GO:0102751,UDP-alpha-D-glucose	GO:0005978,glycogen biosynthetic process;GO:0043312,neutrophil degranulation	hsa:2992,path:hsa00500,Starch and sucrose metabolism
RAP1B_HUMAN	P61224	RAP1B	Ras-related protein Rap-1b	8.764030042	31.74182666	2.037008485	1.739228282	20.252928351	1.8881183835	20.252928351	1.8881183835	10.7265140406383	0.015090	1	0.0932269324602026	0.014902	-1	GO:0035577,azurophil granule membrane;GO:0005911,cell-cell junction;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005811,lipid droplet;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0003925,G protein activity;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0044877,protein-containing complex binding	GO:0002250,adaptive immune response;GO:0008283,cell population proliferation;GO:0071320,cellular response to cAMP;GO:0035690,cellular response to drug;GO:0097211,cellular response to gonadotropin-releasing hormone;GO:0061028,establishment of endothelial barrier;GO:0035722,interleukin-12-mediated signaling pathway;GO:0045955,negative regulation of calcium ion-dependent exocytosis;GO:2000301,negative regulation of synaptic vesicle exocytosis;GO:0043312,neutrophil degranulation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0033625,positive regulation of integrin activation;GO:0032486,Rap protein signal transduction;GO:1901888,regulation of cell junction assembly;GO:2000114,regulation of establishment of cell polarity;GO:0009743,response to carbohydrate;GO:0007165,signal transduction	hsa:5908,path:hsa04014,Ras signaling pathway;hsa:5908,path:hsa04015,Rap1 signaling pathway;hsa:5908,path:hsa04010,MAPK signaling pathway;hsa:5908,path:hsa04024,cAMP signaling pathway;hsa:5908,path:hsa04510,Focal adhesion;hsa:5908,path:hsa04611,Platelet activation;hsa:5908,path:hsa04670,Leukocyte transendothelial migration;hsa:5908,path:hsa04062,Chemokine signaling pathway;hsa:5908,path:hsa04972,Pancreatic secretion;hsa:5908,path:hsa04720,Long-term potentiation;hsa:5908,path:hsa04722,Neurotrophin signaling pathway;hsa:5908,path:hsa05211,Renal cell carcinoma;hsa:5908,path:hsa04934,Cushing syndrome
GALT1_HUMAN	Q10472	GALNT1	Polypeptide N-acetylgalactosaminyltransferase 1	0.126542381	0.193746295	0.201873587	0.131228766	0.160144338	0.1665511765	0.160144338	0.1665511765	0.961532313162615	0.446391	0	1.04000665012584	0.446222	0	GO:0005789,endoplasmic reticulum membrane;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005576,extracellular region;GO:0032580,Golgi cisterna membrane;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm	GO:0030246,carbohydrate binding;GO:0030145,manganese ion binding;GO:0004653,polypeptide N-acetylgalactosaminyltransferase activity	GO:0016266,O-glycan processing;GO:0006493,protein O-linked glycosylation;GO:0018242,protein O-linked glycosylation via serine;GO:0018243,protein O-linked glycosylation via threonine;GO:0019082,viral protein processing	hsa:2589,path:hsa00512,Mucin type O-glycan biosynthesis;hsa:2589,path:hsa00514,Other types of O-glycan biosynthesis
KGUA_HUMAN	Q16774	GUK1	Guanylate kinase	0.679002674	0.616418037	0.04713702	2.55E-05	0.6477103555	0.02358126	0.6477103555	0.02358126	27.4671648376719	0.001537	1	0.0364071066638983	0.001504	-1	GO:0005829,cytosol;GO:0001917,photoreceptor inner segment	GO:0005524,ATP binding;GO:0004385,guanylate kinase activity	GO:0006185,dGDP biosynthetic process;GO:0015949,nucleobase-containing small molecule interconversion;GO:0006163,purine nucleotide metabolic process;GO:0006805,xenobiotic metabolic process	hsa:2987,path:hsa00230,Purine metabolism
RAGP1_HUMAN	P46060	RANGAP1	Ran GTPase-activating protein 1	1.208155275	1.084675306	1.499409671	1.075652226	1.1464152905	1.2875309485	1.1464152905	1.2875309485	0.890398240007821	0.472095	0	1.12309296567255	0.471983	0	GO:0016235,aggresome;GO:1904115,axon cytoplasm;GO:0000777,condensed chromosome kinetochore;GO:0005737,cytoplasm;GO:1990723,cytoplasmic periphery of the nuclear pore complex;GO:0005829,cytosol;GO:0030425,dendrite;GO:0043231,intracellular membrane-bounded organelle;GO:0072686,mitotic spindle;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0005643,nuclear pore;GO:0044614,nuclear pore cytoplasmic filaments;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm	GO:0045296,cadherin binding;GO:0005096,GTPase activator activity;GO:0003723,RNA binding;GO:0031267,small GTPase binding;GO:0031625,ubiquitin protein ligase binding	GO:0090630,activation of GTPase activity;GO:1904117,cellular response to vasopressin;GO:0007084,mitotic nuclear envelope reassembly;GO:0007052,mitotic spindle organization;GO:0046826,negative regulation of protein export from nucleus;GO:0016925,protein sumoylation;GO:0048678,response to axon injury;GO:0007165,signal transduction	hsa:5905,path:hsa03013,RNA transport
LANC2_HUMAN	Q9NS86	LANCL2	LanC-like protein 2	0.121930857	0.180240487	0.087689105	0.133490681	0.151085672	0.110589893	0.151085672	0.110589893	1.36617974664285	0.333293	0	0.731968104824659	0.332898	0	GO:0030864,cortical actin cytoskeleton;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0005524,ATP binding;GO:0005525,GTP binding;GO:0032266,phosphatidylinositol-3-phosphate binding;GO:0070273,phosphatidylinositol-4-phosphate binding;GO:0010314,phosphatidylinositol-5-phosphate binding	GO:0005975,carbohydrate metabolic process;GO:0045892,negative regulation of transcription, DNA-templated;GO:0009789,positive regulation of abscisic acid-activated signaling pathway	
RAB6B_HUMAN	Q9NRW1	RAB6B	Ras-related protein Rab-6B	1.294572926	1.528921687	0.083242003	0.027026414	1.4117473065	0.0551342085	1.4117473065	0.0551342085	25.6056510995347	0.001859	1	0.0390538790094727	0.001820	-1	GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0012505,endomembrane system;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0098793,presynapse	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0031489,myosin V binding	GO:0006891,intra-Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0042147,retrograde transport, endosome to Golgi;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	
DDAH2_HUMAN	O95865	DDAH2	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2	1.983438872	2.107470372	1.636862345	4.367862592	2.045454622	3.0023624685	2.045454622	3.0023624685	0.68128170514399	0.388908	0	1.46782159633752	0.389119	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005739,mitochondrion	GO:0016597,amino acid binding;GO:0003824,catalytic activity;GO:0016403,dimethylargininase activity	GO:0006527,arginine catabolic process;GO:0006525,arginine metabolic process;GO:0000052,citrulline metabolic process;GO:0043066,negative regulation of apoptotic process;GO:0006809,nitric oxide biosynthetic process;GO:0007263,nitric oxide mediated signal transduction;GO:0045429,positive regulation of nitric oxide biosynthetic process;GO:0050999,regulation of nitric-oxide synthase activity	
EFGM_HUMAN	Q96RP9	GFM1	Elongation factor G, mitochondrial	0.20758657	0.283664023	0.956515098	0.728987156	0.2456252965	0.842751127	0.2456252965	0.842751127	0.291456503148645	0.057082	0	3.43104370359508	0.057316	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0003723,RNA binding;GO:0003746,translation elongation factor activity	GO:0070125,mitochondrial translational elongation	
ANT3_HUMAN	P01008	SERPINC1	Antithrombin-III	3.870463535	2.798065401	6.329049616	28.40298558	3.334264468	17.366017598	3.334264468	17.366017598	0.19199937171456	0.013290	-1	5.20835037672243	0.013385	1	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane	GO:0008201,heparin binding;GO:0042802,identical protein binding;GO:0002020,protease binding;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0002438,acute inflammatory response to antigenic stimulus;GO:0007596,blood coagulation;GO:0044267,cellular protein metabolic process;GO:0007595,lactation;GO:0010951,negative regulation of endopeptidase activity;GO:0043687,post-translational protein modification;GO:2000266,regulation of blood coagulation, intrinsic pathway;GO:0007584,response to nutrient	hsa:462,path:hsa04610,Complement and coagulation cascades
IF4A1_HUMAN	P60842	EIF4A1	Eukaryotic initiation factor 4A-I	27.77680021	43.24584862	31.08879246	19.9532235	35.511324415	25.52100798	35.511324415	25.52100798	1.39145461820431	0.327695	0	0.718672378471469	0.327289	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016281,eukaryotic translation initiation factor 4F complex;GO:0070062,extracellular exosome;GO:0016020,membrane	GO:0005524,ATP binding;GO:0003725,double-stranded RNA binding;GO:0004386,helicase activity;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0000339,RNA cap binding;GO:0003724,RNA helicase activity;GO:0008135,translation factor activity, RNA binding;GO:0003743,translation initiation factor activity;GO:0003676,nucleic acid binding;GO:0016787,hydrolase activity	GO:0002183,cytoplasmic translational initiation;GO:0006413,translational initiation;GO:0016032,viral process	hsa:1973,path:hsa03013,RNA transport
COX5A_HUMAN	P20674	COX5A	Cytochrome c oxidase subunit 5A, mitochondrial	18.07169937	5.019565235	2.670896937	98.43958452	11.5456323025	50.5552407285	11.5456323025	50.5552407285	0.228376566625491	0.025441	-1	4.3787329618624	0.025588	1	GO:0005743,mitochondrial inner membrane;GO:0005751,mitochondrial respiratory chain complex IV	GO:0004129,cytochrome-c oxidase activity;GO:0009055,electron transfer activity;GO:0046872,metal ion binding	GO:0006123,mitochondrial electron transport, cytochrome c to oxygen;GO:0006119,oxidative phosphorylation	hsa:9377,path:hsa00190,Oxidative phosphorylation;hsa:9377,path:hsa04260,Cardiac muscle contraction;hsa:9377,path:hsa04714,Thermogenesis;hsa:9377,path:hsa05010,Alzheimer disease;hsa:9377,path:hsa05012,Parkinson disease;hsa:9377,path:hsa05016,Huntington disease;hsa:9377,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
ZW10_HUMAN	O43264	ZW10	Centromere/kinetochore protein zw10 homolog	0.268728946	0.238184524	0.305863237	0.188647052	0.253456735	0.2472551445	0.253456735	0.2472551445	1.02508174506355	0.425153	0	0.975531956173901	0.424938	0	GO:0000777,condensed chromosome kinetochore;GO:0005829,cytosol;GO:0070939,Dsl1/NZR complex;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0000776,kinetochore;GO:0005828,kinetochore microtubule;GO:0005811,lipid droplet;GO:0016020,membrane;GO:0005634,nucleus;GO:1990423,RZZ complex;GO:0000922,spindle pole;GO:0005737,cytoplasm	GO:0019237,centromeric DNA binding	GO:0051301,cell division;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0000132,establishment of mitotic spindle orientation;GO:0007030,Golgi organization;GO:0051321,meiotic cell cycle;GO:0007080,mitotic metaphase plate congression;GO:0000070,mitotic sister chromatid segregation;GO:0007094,mitotic spindle assembly checkpoint;GO:0007052,mitotic spindle organization;GO:0034501,protein localization to kinetochore;GO:0015031,protein transport;GO:0065003,protein-containing complex assembly;GO:0007096,regulation of exit from mitosis;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0072413,signal transduction involved in mitotic cell cycle checkpoint;GO:0000278,mitotic cell cycle	
RAP2A_HUMAN	P10114	RAP2A	Ras-related protein Rap-2a	0.042692159	0.105351336	0.008552167	0.009642558	0.0740217475	0.0090973625	0.0740217475	0.0090973625	8.13661624454341	0.026507	1	0.122901212241713	0.026235	-1	GO:0005829,cytosol;GO:0030496,midbody;GO:0005886,plasma membrane;GO:0055037,recycling endosome;GO:0055038,recycling endosome membrane;GO:0016020,membrane	GO:0003925,G protein activity;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0000287,magnesium ion binding	GO:0031532,actin cytoskeleton reorganization;GO:0034613,cellular protein localization;GO:0035690,cellular response to drug;GO:0045184,establishment of protein localization;GO:0030033,microvillus assembly;GO:0030336,negative regulation of cell migration;GO:0031954,positive regulation of protein autophosphorylation;GO:0001934,positive regulation of protein phosphorylation;GO:0072659,protein localization to plasma membrane;GO:0032486,Rap protein signal transduction;GO:0048814,regulation of dendrite morphogenesis;GO:0046328,regulation of JNK cascade;GO:0007165,signal transduction	
IPYR2_HUMAN	Q9H2U2	PPA2	Inorganic pyrophosphatase 2, mitochondrial	0.761471056	0.412602084	4.239386342	22.17719776	0.58703657	13.208292051	0.58703657	13.208292051	0.0444445479955567	0.000004	-1	22.4999475773715	0.000004	1	GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005737,cytoplasm	GO:0004427,inorganic diphosphatase activity;GO:0000287,magnesium ion binding;GO:0004722,protein serine/threonine phosphatase activity	GO:0071344,diphosphate metabolic process;GO:0006796,phosphate-containing compound metabolic process;GO:0051881,regulation of mitochondrial membrane potential;GO:0006418,tRNA aminoacylation for protein translation	hsa:27068,path:hsa00190,Oxidative phosphorylation
STA5B_HUMAN	P51692	STAT5B	Signal transducer and activator of transcription 5B	0.161637476	0.292178545	0.383695344	0.392111689	0.2269080105	0.3879035165	0.2269080105	0.3879035165	0.584959921341677	0.303236	0	1.70951882943771	0.303522	0	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003682,chromatin binding;GO:0001228,DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700,DNA-binding transcription factor activity;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0035259,glucocorticoid receptor binding;GO:0042802,identical protein binding;GO:0046983,protein dimerization activity;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0071364,cellular response to epidermal growth factor stimulus;GO:0071363,cellular response to growth factor stimulus;GO:0032870,cellular response to hormone stimulus;GO:0019221,cytokine-mediated signaling pathway;GO:0006952,defense response;GO:0046543,development of secondary female sexual characteristics;GO:0046544,development of secondary male sexual characteristics;GO:0007565,female pregnancy;GO:0060397,growth hormone receptor signaling pathway via JAK-STAT;GO:0035723,interleukin-15-mediated signaling pathway;GO:0038110,interleukin-2-mediated signaling pathway;GO:0038111,interleukin-7-mediated signaling pathway;GO:0038113,interleukin-9-mediated signaling pathway;GO:0007595,lactation;GO:0019915,lipid storage;GO:0001553,luteinization;GO:0097531,mast cell migration;GO:0001779,natural killer cell differentiation;GO:0043066,negative regulation of apoptotic process;GO:0045647,negative regulation of erythrocyte differentiation;GO:0048541,Peyer's patch development;GO:0042104,positive regulation of activated T cell proliferation;GO:0045579,positive regulation of B cell differentiation;GO:0045648,positive regulation of erythrocyte differentiation;GO:0045588,positive regulation of gamma-delta T cell differentiation;GO:0050729,positive regulation of inflammatory response;GO:0032743,positive regulation of interleukin-2 production;GO:0045931,positive regulation of mitotic cell cycle;GO:0040018,positive regulation of multicellular organism growth;GO:0032825,positive regulation of natural killer cell differentiation;GO:0045954,positive regulation of natural killer cell mediated cytotoxicity;GO:0032819,positive regulation of natural killer cell proliferation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0042448,progesterone metabolic process;GO:0007259,receptor signaling pathway via JAK-STAT;GO:0042127,regulation of cell population proliferation;GO:0030856,regulation of epithelial cell differentiation;GO:0040014,regulation of multicellular organism growth;GO:0019218,regulation of steroid metabolic process;GO:0006357,regulation of transcription by RNA polymerase II;GO:0032355,response to estradiol;GO:0070670,response to interleukin-4;GO:0043434,response to peptide hormone;GO:0033077,T cell differentiation in thymus;GO:0043029,T cell homeostasis;GO:0019530,taurine metabolic process	hsa:6777,path:hsa04012,ErbB signaling pathway;hsa:6777,path:hsa04630,Jak-STAT signaling pathway;hsa:6777,path:hsa04217,Necroptosis;hsa:6777,path:hsa04658,Th1 and Th2 cell differentiation;hsa:6777,path:hsa04659,Th17 cell differentiation;hsa:6777,path:hsa04062,Chemokine signaling pathway;hsa:6777,path:hsa04917,Prolactin signaling pathway;hsa:6777,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:6777,path:hsa05200,Pathways in cancer;hsa:6777,path:hsa05203,Viral carcinogenesis;hsa:6777,path:hsa05221,Acute myeloid leukemia;hsa:6777,path:hsa05220,Chronic myeloid leukemia;hsa:6777,path:hsa05223,Non-small cell lung cancer;hsa:6777,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:6777,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:6777,path:hsa05162,Measles;hsa:6777,path:hsa05161,Hepatitis B
THAS_HUMAN	P24557	TBXAS1	Thromboxane-A synthase	1.275240855	1.108194668	1.954577048	1.708790537	1.1917177615	1.8316837925	1.1917177615	1.8316837925	0.650613258893047	0.362210	0	1.53701140628674	0.362447	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane	GO:0036134,12-hydroxyheptadecatrienoic acid synthase activity;GO:0020037,heme binding;GO:0106256,hydroperoxy icosatetraenoate dehydratase activity;GO:0005506,iron ion binding;GO:0004497,monooxygenase activity;GO:0016705,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0004796,thromboxane-A synthase activity	GO:0019371,cyclooxygenase pathway;GO:0006690,icosanoid metabolic process;GO:0001516,prostaglandin biosynthetic process;GO:0030644,cellular chloride ion homeostasis;GO:0045907,positive regulation of vasoconstriction;GO:0045471,response to ethanol;GO:0070542,response to fatty acid	hsa:6916,path:hsa00590,Arachidonic acid metabolism;hsa:6916,path:hsa04611,Platelet activation
PP1G_HUMAN	P36873	PPP1CC	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	0.143833534	0.109851357	0.171987357	0.201457394	0.1268424455	0.1867223755	0.1268424455	0.1867223755	0.679310367385509	0.387211	0	1.47208116939057	0.387424	0	GO:0032154,cleavage furrow;GO:0000777,condensed chromosome kinetochore;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0030496,midbody;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0016607,nuclear speck;GO:0005730,nucleolus;GO:0005634,nucleus;GO:0098793,presynapse;GO:0000164,protein phosphatase type 1 complex;GO:0032991,protein-containing complex;GO:0072357,PTW/PP1 phosphatase complex;GO:0005654,nucleoplasm	GO:0005521,lamin binding;GO:0046872,metal ion binding;GO:0016791,phosphatase activity;GO:0008022,protein C-terminus binding;GO:0019904,protein domain specific binding;GO:0019901,protein kinase binding;GO:0047485,protein N-terminus binding;GO:0008157,protein phosphatase 1 binding;GO:0106306,protein serine phosphatase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0106307,protein threonine phosphatase activity;GO:0044877,protein-containing complex binding;GO:0003723,RNA binding	GO:0051301,cell division;GO:0032922,circadian regulation of gene expression;GO:0043153,entrainment of circadian clock by photoperiod;GO:0005977,glycogen metabolic process;GO:0000165,MAPK cascade;GO:0007052,mitotic spindle organization;GO:0030182,neuron differentiation;GO:0060252,positive regulation of glial cell proliferation;GO:0006470,protein dephosphorylation;GO:0042752,regulation of circadian rhythm;GO:0046822,regulation of nucleocytoplasmic transport	hsa:5501,path:hsa03015,mRNA surveillance pathway;hsa:5501,path:hsa04390,Hippo signaling pathway;hsa:5501,path:hsa04024,cAMP signaling pathway;hsa:5501,path:hsa04022,cGMP-PKG signaling pathway;hsa:5501,path:hsa04114,Oocyte meiosis;hsa:5501,path:hsa04218,Cellular senescence;hsa:5501,path:hsa04510,Focal adhesion;hsa:5501,path:hsa04810,Regulation of actin cytoskeleton;hsa:5501,path:hsa04611,Platelet activation;hsa:5501,path:hsa04910,Insulin signaling pathway;hsa:5501,path:hsa04921,Oxytocin signaling pathway;hsa:5501,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:5501,path:hsa04270,Vascular smooth muscle contraction;hsa:5501,path:hsa04728,Dopaminergic synapse;hsa:5501,path:hsa04720,Long-term potentiation;hsa:5501,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:5501,path:hsa05205,Proteoglycans in cancer;hsa:5501,path:hsa05031,Amphetamine addiction;hsa:5501,path:hsa05034,Alcoholism;hsa:5501,path:hsa04931,Insulin resistance;hsa:5501,path:hsa05168,Herpes simplex virus 1 infection
EI2BA_HUMAN	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.616370198	0.66139255	0.799490526	0.367910516	0.638881374	0.583700521	0.638881374	0.583700521	1.09453624078571	0.403621	0	0.913628953283587	0.403362	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005851,eukaryotic translation initiation factor 2B complex;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0042802,identical protein binding;GO:0003743,translation initiation factor activity	GO:0014003,oligodendrocyte development;GO:0050790,regulation of catalytic activity;GO:0006446,regulation of translational initiation;GO:0009749,response to glucose;GO:0009408,response to heat;GO:0043434,response to peptide hormone;GO:0050852,T cell receptor signaling pathway;GO:0006413,translational initiation	hsa:1967,path:hsa03013,RNA transport;hsa:1967,path:hsa05168,Herpes simplex virus 1 infection
ATP5H_HUMAN	O75947	ATP5PD	ATP synthase subunit d, mitochondrial	23.83175737	12.07656365	11.55548746	0.684102843	17.95416051	6.1197951515	17.95416051	6.1197951515	2.93378455741273	0.141184	0	0.340856658159619	0.140619	0	GO:0005743,mitochondrial inner membrane;GO:0005753,mitochondrial proton-transporting ATP synthase complex;GO:0000274,mitochondrial proton-transporting ATP synthase, stator stalk;GO:0005739,mitochondrion;GO:0000276,mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	GO:0044877,protein-containing complex binding;GO:0015078,proton transmembrane transporter activity	GO:0006754,ATP biosynthetic process;GO:0015986,ATP synthesis coupled proton transport;GO:1901653,cellular response to peptide;GO:0042407,cristae formation;GO:0042776,mitochondrial ATP synthesis coupled proton transport	hsa:10476,path:hsa00190,Oxidative phosphorylation;hsa:10476,path:hsa04714,Thermogenesis;hsa:10476,path:hsa05010,Alzheimer disease;hsa:10476,path:hsa05012,Parkinson disease;hsa:10476,path:hsa05016,Huntington disease
QSPP_HUMAN	Q5T6V5	C9orf64	Queuosine salvage protein	0.323866821	0.275623277	0.451076439	0.238868627	0.299745049	0.344972533	0.299745049	0.344972533	0.868895405652484	0.480301	0	1.15088650888776	0.480207	0			GO:0006400,tRNA modification;GO:0101030,tRNA-guanine transglycosylation	
CMC1_HUMAN	O75746	SLC25A12	Calcium-binding mitochondrial carrier protein Aralar1	2.138673651	2.803216874	3.842499957	3.372716044	2.4709452625	3.6076080005	2.4709452625	3.6076080005	0.684926206549475	0.392037	0	1.46001129820657	0.392245	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion	GO:0005509,calcium ion binding;GO:0042802,identical protein binding;GO:0015183,L-aspartate transmembrane transporter activity;GO:0005313,L-glutamate transmembrane transporter activity;GO:0022857,transmembrane transporter activity	GO:0009066,aspartate family amino acid metabolic process;GO:0015810,aspartate transmembrane transport;GO:0006094,gluconeogenesis;GO:0006537,glutamate biosynthetic process;GO:0015813,L-glutamate transmembrane transport;GO:0043490,malate-aspartate shuttle;GO:1904024,negative regulation of glucose catabolic process to lactate via pyruvate;GO:2001171,positive regulation of ATP biosynthetic process;GO:0010907,positive regulation of glucose metabolic process;GO:0031643,positive regulation of myelination;GO:0051592,response to calcium ion;GO:0006851,mitochondrial calcium ion transmembrane transport	
PTAR1_HUMAN	Q7Z6K3	PTAR1	Protein prenyltransferase alpha subunit repeat-containing protein 1	0.026993131	0.00364865	0.109277611	0.062695944	0.0153208905	0.0859867775	0.0153208905	0.0859867775	0.178177284292344	0.009855	-1	5.61238770683728	0.009932	1	GO:0005737,cytoplasm	GO:0008318,protein prenyltransferase activity	GO:0018342,protein prenylation	
XPP1_HUMAN	Q9NQW7	XPNPEP1	Xaa-Pro aminopeptidase 1	0.945808164	0.664315774	1.13899089	1.678130748	0.805061969	1.408560819	0.805061969	1.408560819	0.571549313413069	0.290968	0	1.7496303057883	0.291262	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0004177,aminopeptidase activity;GO:0030145,manganese ion binding;GO:0070006,metalloaminopeptidase activity;GO:0042803,protein homodimerization activity;GO:0046872,metal ion binding;GO:0016787,hydrolase activity	GO:0010815,bradykinin catabolic process;GO:0006508,proteolysis	
F16P1_HUMAN	P09467	FBP1	Fructose-1,6-bisphosphatase 1	4.177648215	37.68830177	9.798833007	11.38403184	20.9329749925	10.5914324235	20.9329749925	10.5914324235	1.97640641562839	0.229021	0	0.505968808890985	0.228481	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0016208,AMP binding;GO:0042132,fructose 1,6-bisphosphate 1-phosphatase activity;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0048029,monosaccharide binding;GO:0001085,RNA polymerase II transcription factor binding	GO:0035690,cellular response to drug;GO:0071286,cellular response to magnesium ion;GO:0016311,dephosphorylation;GO:0030388,fructose 1,6-bisphosphate metabolic process;GO:0006002,fructose 6-phosphate metabolic process;GO:0006000,fructose metabolic process;GO:0006094,gluconeogenesis;GO:0030308,negative regulation of cell growth;GO:0045820,negative regulation of glycolytic process;GO:0046580,negative regulation of Ras protein signal transduction;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0006111,regulation of gluconeogenesis;GO:0005986,sucrose biosynthetic process;GO:0005975,carbohydrate metabolic process	hsa:2203,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:2203,path:hsa00030,Pentose phosphate pathway;hsa:2203,path:hsa00051,Fructose and mannose metabolism;hsa:2203,path:hsa04152,AMPK signaling pathway;hsa:2203,path:hsa04910,Insulin signaling pathway;hsa:2203,path:hsa04922,Glucagon signaling pathway
CASP_HUMAN	Q13948	CUX1	Protein CASP	2.55E-05	0.036920813	2.55E-05	2.55E-05	0.0184731565	2.55e-005	0.0184731565	2.55e-005	724.437509803922	0.000000	1	0.0013803813116616	0.000000	-1	GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0030173,integral component of Golgi membrane;GO:0005654,nucleoplasm;GO:0000785,chromatin;GO:0005829,cytosol;GO:0005634,nucleus	GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0030674,protein-macromolecule adaptor activity;GO:0000977,RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0043565,sequence-specific DNA binding;GO:1990837,sequence-specific double-stranded DNA binding;GO:0003677,DNA binding	GO:0006891,intra-Golgi vesicle-mediated transport;GO:0007275,multicellular organism development;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0050775,positive regulation of dendrite morphogenesis;GO:0006357,regulation of transcription by RNA polymerase II;GO:0000301,retrograde transport, vesicle recycling within Golgi	
ELYS_HUMAN	Q8WYP5	AHCTF1	Protein ELYS	0.022018309	0.024637303	0.076142857	0.030637445	0.023327806	0.053390151	0.023327806	0.053390151	0.436930886372657	0.168276	0	2.28869148688908	0.168610	0	GO:0000777,condensed chromosome kinetochore;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016363,nuclear matrix;GO:0031965,nuclear membrane;GO:0005643,nuclear pore;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003677,DNA binding	GO:0051301,cell division;GO:0007084,mitotic nuclear envelope reassembly;GO:0007052,mitotic spindle organization;GO:0051028,mRNA transport;GO:0051292,nuclear pore complex assembly;GO:0015031,protein transport;GO:0032465,regulation of cytokinesis	
IDH3B_HUMAN	O43837	IDH3B	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	1.153497182	0.373699507	1.653264442	1.198844123	0.7635983445	1.4260542825	0.7635983445	1.4260542825	0.53546232697492	0.257771	0	1.86754501600416	0.258086	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0009055,electron transfer activity;GO:0004449,isocitrate dehydrogenase (NAD+) activity;GO:0000287,magnesium ion binding;GO:0051287,NAD binding;GO:0016616,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO:0006102,isocitrate metabolic process;GO:0006099,tricarboxylic acid cycle;GO:0006103,2-oxoglutarate metabolic process;GO:0006734,NADH metabolic process	hsa:3420,path:hsa00020,Citrate cycle (TCA cycle)
CTHR1_HUMAN	Q96CG8	CTHRC1	Collagen triple helix repeat-containing protein 1	0.844337584	4.459730286	0.150659303	2.55E-05	2.652033935	0.0753424015	2.652033935	0.0753424015	35.1997531562622	0.000764	1	0.0284092901322547	0.000745	-1	GO:0005581,collagen trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0005109,frizzled binding;GO:0017147,Wnt-protein binding	GO:0016477,cell migration;GO:0090103,cochlea morphogenesis;GO:0090177,establishment of planar polarity involved in neural tube closure;GO:0060122,inner ear receptor cell stereocilium organization;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0043932,ossification involved in bone remodeling;GO:0045669,positive regulation of osteoblast differentiation;GO:0033690,positive regulation of osteoblast proliferation;GO:0032092,positive regulation of protein binding;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	
FIBB_HUMAN	P02675	FGB	Fibrinogen beta chain	16.88213395	45.22863814	137.3634978	274.7229401	31.055386045	206.04321895	31.055386045	206.04321895	0.15072267946142	0.004833	-1	6.63470158288931	0.004878	1	GO:0072562,blood microparticle;GO:0005938,cell cortex;GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0005783,endoplasmic reticulum;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1903561,extracellular vesicle;GO:0005577,fibrinogen complex;GO:0005886,plasma membrane;GO:0031091,platelet alpha granule;GO:0031093,platelet alpha granule lumen;GO:0045202,synapse	GO:0051087,chaperone binding;GO:0005201,extracellular matrix structural constituent;GO:0005102,signaling receptor binding;GO:0005198,structural molecule activity	GO:0002250,adaptive immune response;GO:0007596,blood coagulation;GO:0072378,blood coagulation, fibrin clot formation;GO:0007155,cell adhesion;GO:0007160,cell-matrix adhesion;GO:0034622,cellular protein-containing complex assembly;GO:0071347,cellular response to interleukin-1;GO:0044320,cellular response to leptin stimulus;GO:0030198,extracellular matrix organization;GO:0042730,fibrinolysis;GO:0043152,induction of bacterial agglutination;GO:0045087,innate immune response;GO:2000352,negative regulation of endothelial cell apoptotic process;GO:1902042,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0031639,plasminogen activation;GO:0070527,platelet aggregation;GO:0002576,platelet degranulation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0045921,positive regulation of exocytosis;GO:0034116,positive regulation of heterotypic cell-cell adhesion;GO:0090277,positive regulation of peptide hormone secretion;GO:0050714,positive regulation of protein secretion;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0045907,positive regulation of vasoconstriction;GO:0051258,protein polymerization;GO:0051592,response to calcium ion;GO:0002224,toll-like receptor signaling pathway	hsa:2244,path:hsa04610,Complement and coagulation cascades;hsa:2244,path:hsa04611,Platelet activation
SGMR1_HUMAN	Q99720	SIGMAR1	Sigma non-opioid intracellular receptor 1	0.135441527	0.135873393	0.228163836	2.55E-05	0.13565746	0.114094668	0.13565746	0.114094668	1.18899035667469	0.376855	0	0.841049714479395	0.376541	0	GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0030426,growth cone;GO:0016021,integral component of membrane;GO:0005811,lipid droplet;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0005637,nuclear inner membrane;GO:0005640,nuclear outer membrane;GO:0014069,postsynaptic density;GO:0098839,postsynaptic density membrane	GO:0042802,identical protein binding;GO:0004985,opioid receptor activity	GO:0036474,cell death in response to hydrogen peroxide;GO:0006869,lipid transport;GO:0007399,nervous system development;GO:0070207,protein homotrimerization;GO:0043523,regulation of neuron apoptotic process	
MZB1_HUMAN	Q8WU39	MZB1	Marginal zone B- and B1-cell-specific protein	3.433409088	1.464556202	1.482746348	0.240647184	2.448982645	0.861696766	2.448982645	0.861696766	2.84204692605287	0.147264	0	0.351859074117693	0.146697	0	GO:0005737,cytoplasm;GO:0034663,endoplasmic reticulum chaperone complex;GO:0005788,endoplasmic reticulum lumen;GO:0005576,extracellular region		GO:0006915,apoptotic process;GO:0033622,integrin activation;GO:0008284,positive regulation of cell population proliferation;GO:0002639,positive regulation of immunoglobulin production;GO:0030888,regulation of B cell proliferation;GO:0042127,regulation of cell population proliferation;GO:0046626,regulation of insulin receptor signaling pathway	
VMA21_HUMAN	Q3ZAQ7	VMA21	Vacuolar ATPase assembly integral membrane protein VMA21	4.395382352	10.64291163	4.986299842	9.156756353	7.519146991	7.0715280975	7.519146991	7.0715280975	1.0632987506135	0.413099	0	0.940469458299489	0.412859	0	GO:0005789,endoplasmic reticulum membrane;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0016021,integral component of membrane;GO:0005764,lysosome;GO:0005773,vacuole		GO:0043462,regulation of ATPase activity;GO:0070072,vacuolar proton-transporting V-type ATPase complex assembly	
LORF1_HUMAN	Q9UN81	L1RE1	LINE-1 retrotransposable element ORF1 protein	2.55E-05	2.55E-05	2.55E-05	2.55E-05	2.55e-005	2.55e-005	2.55e-005	2.55e-005	1	0.433351	0	1	0.433154	0	GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0010494,cytoplasmic stress granule;GO:0005730,nucleolus;GO:1990904,ribonucleoprotein complex	GO:0042802,identical protein binding;GO:0000166,nucleotide binding;GO:0003697,single-stranded DNA binding;GO:0003727,single-stranded RNA binding	GO:0032197,transposition, RNA-mediated	
PUR6_HUMAN	P22234	PAICS	Multifunctional protein ADE2	3.244615984	1.429580754	3.460077027	1.47079198	2.337098369	2.4654345035	2.337098369	2.4654345035	0.947945834976427	0.451136	0	1.05491259426744	0.450978	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane	GO:0043727,5-amino-4-imidazole carboxylate lyase activity;GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0004638,phosphoribosylaminoimidazole carboxylase activity;GO:0004639,phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	GO:0006189,'de novo' IMP biosynthetic process;GO:0009113,purine nucleobase biosynthetic process;GO:0009168,purine ribonucleoside monophosphate biosynthetic process	hsa:10606,path:hsa00230,Purine metabolism
MCM4_HUMAN	P33991	MCM4	DNA replication licensing factor MCM4	0.809353082	0.76363718	0.604297225	0.60533798	0.786495131	0.6048176025	0.786495131	0.6048176025	1.30038399634706	0.348551	0	0.76900361955324	0.348183	0	GO:0000781,chromosome, telomeric region;GO:0071162,CMG complex;GO:0042555,MCM complex;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005694,chromosome	GO:0005524,ATP binding;GO:0003678,DNA helicase activity;GO:0003688,DNA replication origin binding;GO:0016787,hydrolase activity;GO:0003697,single-stranded DNA binding;GO:0003677,DNA binding	GO:0006260,DNA replication;GO:0006270,DNA replication initiation;GO:0006271,DNA strand elongation involved in DNA replication;GO:0006268,DNA unwinding involved in DNA replication;GO:0000727,double-strand break repair via break-induced replication;GO:1902975,mitotic DNA replication initiation;GO:0036388,pre-replicative complex assembly;GO:0006267,pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0007049,cell cycle	hsa:4173,path:hsa03030,DNA replication;hsa:4173,path:hsa04110,Cell cycle
TBCB_HUMAN	Q99426	TBCB	Tubulin-folding cofactor B	2.07743426	1.314903015	1.170500404	1.080686801	1.6961686375	1.1255936025	1.6961686375	1.1255936025	1.50691033933804	0.303810	0	0.663609488829497	0.303365	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005874,microtubule;GO:0015630,microtubule cytoskeleton		GO:0030154,cell differentiation;GO:0007399,nervous system development	
RS27_HUMAN	P42677	RPS27	40S ribosomal protein S27	0.840676668	0.296805354	0.531528478	0.615472596	0.568741011	0.573500537	0.568741011	0.573500537	0.991700921458771	0.436116	0	1.00836852962587	0.435925	0	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0098982,GABA-ergic synapse;GO:0098978,glutamatergic synapse;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0014069,postsynaptic density;GO:0098793,presynapse;GO:0005840,ribosome	GO:0003677,DNA binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome;GO:0008270,zinc ion binding	GO:0002181,cytoplasmic translation;GO:0007052,mitotic spindle organization;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000028,ribosomal small subunit assembly;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6232,path:hsa03010,Ribosome
FXR1_HUMAN	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	1.297222374	2.486746969	1.845210273	3.817363162	1.8919846715	2.8312867175	1.8919846715	2.8312867175	0.668241990401666	0.377634	0	1.49646387740304	0.377856	0	GO:0030424,axon;GO:0043034,costamere;GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:1902737,dendritic filopodium;GO:0043197,dendritic spine;GO:0044326,dendritic spine neck;GO:0098978,glutamatergic synapse;GO:0030426,growth cone;GO:0016020,membrane;GO:0043025,neuronal cell body;GO:0005730,nucleolus;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005844,polysome;GO:0014069,postsynaptic density;GO:0098793,presynapse	GO:0003730,mRNA 3'-UTR binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0003723,RNA binding;GO:0033592,RNA strand annealing activity;GO:0045182,translation regulator activity;GO:0003729,mRNA binding	GO:0006915,apoptotic process;GO:0030154,cell differentiation;GO:0007517,muscle organ development;GO:0017148,negative regulation of translation;GO:2000637,positive regulation of gene silencing by miRNA;GO:0001934,positive regulation of protein phosphorylation;GO:2001022,positive regulation of response to DNA damage stimulus;GO:0045727,positive regulation of translation;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0051489,regulation of filopodium assembly;GO:0043488,regulation of mRNA stability;GO:0060538,skeletal muscle organ development;GO:0006417,regulation of translation	hsa:8087,path:hsa03013,RNA transport
TIPRL_HUMAN	O75663	TIPRL	TIP41-like protein	1.249728498	0.766010115	0.643096603	0.515049411	1.0078693065	0.579073007	1.0078693065	0.579073007	1.74048745895006	0.262736	0	0.574551683700867	0.262233	0	GO:0005829,cytosol		GO:0000077,DNA damage checkpoint;GO:0032515,negative regulation of phosphoprotein phosphatase activity;GO:0043666,regulation of phosphoprotein phosphatase activity;GO:0031929,TOR signaling	
OSGEP_HUMAN	Q9NPF4	OSGEP	Probable tRNA N6-adenosine threonylcarbamoyltransferase	0.675751902	0.576651074	0.726295516	1.030058976	0.626201488	0.878177246	0.626201488	0.878177246	0.713069589143056	0.415868	0	1.40238767046814	0.416052	0	GO:0005737,cytoplasm;GO:0000408,EKC/KEOPS complex;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0046872,metal ion binding;GO:0061711,N(6)-L-threonylcarbamoyladenine synthase activity	GO:0002949,tRNA threonylcarbamoyladenosine modification	
LRRF2_HUMAN	Q9Y608	LRRFIP2	Leucine-rich repeat flightless-interacting protein 2	0.331571168	0.204988785	0.178867307	1.069523424	0.2682799765	0.6241953655	0.2682799765	0.6241953655	0.429801295120318	0.162031	0	2.32665655351286	0.162365	0		GO:0030275,LRR domain binding	GO:0006355,regulation of transcription, DNA-templated;GO:0016055,Wnt signaling pathway	
PTK7_HUMAN	Q13308	PTK7	Inactive tyrosine-protein kinase 7	0.729386467	0.81168603	0.738603518	0.928371211	0.7705362485	0.8334873645	0.7705362485	0.8334873645	0.924472621084348	0.459514	0	1.0816977995812	0.459374	0	GO:0005911,cell-cell junction;GO:0005925,focal adhesion;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0005524,ATP binding;GO:0050839,cell adhesion molecule binding;GO:1904929,coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway;GO:0004672,protein kinase activity	GO:0031532,actin cytoskeleton reorganization;GO:0003401,axis elongation;GO:0007155,cell adhesion;GO:0016477,cell migration;GO:0071300,cellular response to retinoic acid;GO:0090103,cochlea morphogenesis;GO:0060026,convergent extension;GO:0060976,coronary vasculature development;GO:0045198,establishment of epithelial cell apical/basal polarity;GO:0001736,establishment of planar polarity;GO:0001822,kidney development;GO:0060484,lung-associated mesenchyme development;GO:0090179,planar cell polarity pathway involved in neural tube closure;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0010976,positive regulation of neuron projection development;GO:0060828,regulation of canonical Wnt signaling pathway;GO:0007165,signal transduction;GO:0003281,ventricular septum development;GO:0042060,wound healing;GO:0007411,axon guidance	
CLPT1_HUMAN	O96005	CLPTM1	Cleft lip and palate transmembrane protein 1	0.344797469	0.333582335	0.363546065	0.263308043	0.339189902	0.313427054	0.339189902	0.313427054	1.08219726941632	0.407326	0	0.924045946391411	0.407074	0	GO:0012505,endomembrane system;GO:0009897,external side of plasma membrane;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0016021,integral component of membrane		GO:0030154,cell differentiation;GO:0007275,multicellular organism development;GO:0033081,regulation of T cell differentiation in thymus	
VP37B_HUMAN	Q9H9H4	VPS37B	Vacuolar protein sorting-associated protein 37B	0.103217088	0.081424329	2.55E-05	0.269167042	0.0923207085	0.134596271	0.0923207085	0.134596271	0.685908367401947	0.392879	0	1.45792068959263	0.393086	0	GO:0005737,cytoplasm;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0000813,ESCRT I complex;GO:0070062,extracellular exosome;GO:0043657,host cell;GO:0043231,intracellular membrane-bounded organelle;GO:0031902,late endosome membrane;GO:0030496,midbody;GO:0005886,plasma membrane	GO:0048306,calcium-dependent protein binding	GO:0016197,endosomal transport;GO:0075733,intracellular transport of virus;GO:0016236,macroautophagy;GO:0036258,multivesicular body assembly;GO:1903774,positive regulation of viral budding via host ESCRT complex;GO:1902188,positive regulation of viral release from host cell;GO:0006612,protein targeting to membrane;GO:0006623,protein targeting to vacuole;GO:0043162,ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0039702,viral budding via host ESCRT complex;GO:0019058,viral life cycle;GO:0015031,protein transport	hsa:79720,path:hsa04144,Endocytosis
COF1_HUMAN	P23528	CFL1	Cofilin-1	37.65459224	101.2711847	7.391482835	3.737532877	69.46288847	5.564507856	69.46288847	5.564507856	12.4832043134059	0.010851	1	0.0801076370212164	0.010701	-1	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0031258,lamellipodium membrane;GO:0016020,membrane;GO:0016363,nuclear matrix;GO:0005634,nucleus;GO:0032587,ruffle membrane;GO:0031982,vesicle	GO:0051015,actin filament binding;GO:0003779,actin binding	GO:0030036,actin cytoskeleton organization;GO:0030042,actin filament depolymerization;GO:0030043,actin filament fragmentation;GO:0051014,actin filament severing;GO:0048870,cell motility;GO:0007010,cytoskeleton organization;GO:0051293,establishment of spindle localization;GO:0035722,interleukin-12-mediated signaling pathway;GO:0043066,negative regulation of apoptotic process;GO:0044794,positive regulation by host of viral process;GO:0040019,positive regulation of embryonic development;GO:0022604,regulation of cell morphogenesis;GO:0061001,regulation of dendritic spine morphogenesis;GO:0009615,response to virus;GO:0007266,Rho protein signal transduction;GO:0016032,viral process	hsa:1072,path:hsa04810,Regulation of actin cytoskeleton;hsa:1072,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:1072,path:hsa04360,Axon guidance;hsa:1072,path:hsa05133,Pertussis;hsa:1072,path:hsa05170,Human immunodeficiency virus 1 infection
ELP3_HUMAN	Q9H9T3	ELP3	Elongator complex protein 3	0.065375679	0.090089379	0.15349585	0.144862657	0.077732529	0.1491792535	0.077732529	0.1491792535	0.521067958018707	0.244508	0	1.91913546901324	0.244829	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0033588,elongator holoenzyme complex;GO:0005730,nucleolus;GO:0005634,nucleus	GO:0051539,4 iron, 4 sulfur cluster binding;GO:0016407,acetyltransferase activity;GO:0046872,metal ion binding;GO:0008080,N-acetyltransferase activity;GO:0008607,phosphorylase kinase regulator activity;GO:0000049,tRNA binding;GO:0106261,tRNA uridine(34) acetyltransferase activity	GO:0007417,central nervous system development;GO:0001764,neuron migration;GO:0030335,positive regulation of cell migration;GO:0006357,regulation of transcription by RNA polymerase II;GO:0002926,tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation;GO:0002098,tRNA wobble uridine modification;GO:0008033,tRNA processing	
AP3B2_HUMAN	Q13367	AP3B2	AP-3 complex subunit beta-2	0.017327784	0.034371816	0.020020621	0.028982511	0.0258498	0.024501566	0.0258498	0.024501566	1.05502644198334	0.415665	0	0.947843542309805	0.415430	0	GO:0030123,AP-3 adaptor complex;GO:1904115,axon cytoplasm;GO:0030665,clathrin-coated vesicle membrane;GO:0005794,Golgi apparatus;GO:0097708,intracellular vesicle;GO:0030117,membrane coat	GO:0030276,clathrin binding	GO:0008089,anterograde axonal transport;GO:0048490,anterograde synaptic vesicle transport;GO:0006886,intracellular protein transport;GO:0016192,vesicle-mediated transport	hsa:8120,path:hsa04142,Lysosome
ACTN1_HUMAN	P12814	ACTN1	Alpha-actinin-1	38.4542379	30.10351586	31.92317333	54.60250473	34.27887688	43.26283903	34.27887688	43.26283903	0.79233997695412	0.479510	0	1.26208449540077	0.479624	0	GO:0005903,brush border;GO:0042995,cell projection;GO:0005911,cell-cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005916,fascia adherens;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0005886,plasma membrane;GO:0031093,platelet alpha granule lumen;GO:0031143,pseudopodium;GO:0001726,ruffle;GO:0001725,stress fiber;GO:0030018,Z disc	GO:0051015,actin filament binding;GO:0005509,calcium ion binding;GO:0003725,double-stranded RNA binding;GO:0005178,integrin binding;GO:0044325,ion channel binding;GO:0030374,nuclear receptor coactivator activity;GO:0042803,protein homodimerization activity;GO:0099186,structural constituent of postsynapse;GO:0017166,vinculin binding;GO:0003779,actin binding	GO:0051017,actin filament bundle assembly;GO:0051639,actin filament network formation;GO:0007015,actin filament organization;GO:0048041,focal adhesion assembly;GO:0051271,negative regulation of cellular component movement;GO:0002576,platelet degranulation;GO:0030220,platelet formation;GO:0036344,platelet morphogenesis;GO:0042981,regulation of apoptotic process	hsa:87,path:hsa04510,Focal adhesion;hsa:87,path:hsa04520,Adherens junction;hsa:87,path:hsa04530,Tight junction;hsa:87,path:hsa04810,Regulation of actin cytoskeleton;hsa:87,path:hsa04670,Leukocyte transendothelial migration;hsa:87,path:hsa05203,Viral carcinogenesis;hsa:87,path:hsa05322,Systemic lupus erythematosus;hsa:87,path:hsa05131,Shigellosis;hsa:87,path:hsa05146,Amoebiasis
TRAP1_HUMAN	Q12931	TRAP1	Heat shock protein 75 kDa, mitochondrial	3.019413447	1.844873855	2.513750673	1.597235077	2.432143651	2.055492875	2.432143651	2.055492875	1.18324110026409	0.378407	0	0.845136295364323	0.378097	0	GO:0016020,membrane;GO:0005743,mitochondrial inner membrane;GO:0005758,mitochondrial intermembrane space;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0019901,protein kinase binding;GO:0003723,RNA binding;GO:0005164,tumor necrosis factor receptor binding;GO:0051082,unfolded protein binding	GO:0061077,chaperone-mediated protein folding;GO:1901856,negative regulation of cellular respiration;GO:1903751,negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:1903427,negative regulation of reactive oxygen species biosynthetic process;GO:0006457,protein folding;GO:0009386,translational attenuation	
ORC4_HUMAN	O43929	ORC4	Origin recognition complex subunit 4	2.55E-05	2.55E-05	2.55E-05	2.55E-05	2.55e-005	2.55e-005	2.55e-005	2.55e-005	1	0.433351	0	1	0.433154	0	GO:0000781,chromosome, telomeric region;GO:0005829,cytosol;GO:0005664,nuclear origin of replication recognition complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000808,origin recognition complex	GO:0005524,ATP binding;GO:0003688,DNA replication origin binding;GO:0000166,nucleotide binding;GO:0003677,DNA binding	GO:0006260,DNA replication;GO:0006270,DNA replication initiation;GO:0036388,pre-replicative complex assembly	hsa:5000,path:hsa04110,Cell cycle
DESP_HUMAN	P15924	DSP	Desmoplakin	24.49861981	47.72761588	16.98052003	36.64029118	36.113117845	26.810405605	36.113117845	26.810405605	1.34698140628895	0.337641	0	0.742400745348882	0.337254	0	GO:0016323,basolateral plasma membrane;GO:0001533,cornified envelope;GO:0005737,cytoplasm;GO:0030057,desmosome;GO:0070062,extracellular exosome;GO:0005916,fascia adherens;GO:0101003,ficolin-1-rich granule membrane;GO:0014704,intercalated disc;GO:0005882,intermediate filament;GO:0016020,membrane;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0086083,cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication;GO:0005080,protein kinase C binding;GO:0003723,RNA binding;GO:0097110,scaffold protein binding;GO:0005200,structural constituent of cytoskeleton;GO:0005198,structural molecule activity	GO:0034332,adherens junction organization;GO:0086073,bundle of His cell-Purkinje myocyte adhesion involved in cell communication;GO:0098609,cell-cell adhesion;GO:0070268,cornification;GO:0002934,desmosome organization;GO:0008544,epidermis development;GO:0090136,epithelial cell-cell adhesion;GO:0045104,intermediate filament cytoskeleton organization;GO:0045109,intermediate filament organization;GO:0031424,keratinization;GO:0030216,keratinocyte differentiation;GO:0043312,neutrophil degranulation;GO:0018149,peptide cross-linking;GO:0150105,protein localization to cell-cell junction;GO:0086091,regulation of heart rate by cardiac conduction;GO:0098911,regulation of ventricular cardiac muscle cell action potential;GO:0043588,skin development;GO:0003223,ventricular compact myocardium morphogenesis;GO:0042060,wound healing	hsa:1832,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC)
DKC1_HUMAN	O60832	DKC1	H/ACA ribonucleoprotein complex subunit DKC1	0.427273153	0.359459394	0.568627655	0.551519743	0.3933662735	0.560073699	0.3933662735	0.560073699	0.702347341434435	0.406860	0	1.42379694633378	0.407053	0	GO:0072589,box H/ACA scaRNP complex;GO:0031429,box H/ACA snoRNP complex;GO:0090661,box H/ACA telomerase RNP complex;GO:0005737,cytoplasm;GO:0001650,fibrillar center;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005697,telomerase holoenzyme complex;GO:0016021,integral component of membrane	GO:0034513,box H/ACA snoRNA binding;GO:0009982,pseudouridine synthase activity;GO:0003723,RNA binding;GO:0003720,telomerase activity;GO:0070034,telomerase RNA binding	GO:0000495,box H/ACA RNA 3'-end processing;GO:0000455,enzyme-directed rRNA pseudouridine synthesis;GO:1990481,mRNA pseudouridine synthesis;GO:1904851,positive regulation of establishment of protein localization to telomere;GO:1904871,positive regulation of protein localization to Cajal body;GO:0051973,positive regulation of telomerase activity;GO:1904874,positive regulation of telomerase RNA localization to Cajal body;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:1904872,regulation of telomerase RNA localization to Cajal body;GO:0006396,RNA processing;GO:0006364,rRNA processing;GO:0031118,rRNA pseudouridine synthesis;GO:0090666,scaRNA localization to Cajal body;GO:0031120,snRNA pseudouridine synthesis;GO:0090669,telomerase RNA stabilization;GO:0007004,telomere maintenance via telomerase;GO:0001522,pseudouridine synthesis;GO:0008033,tRNA processing	hsa:1736,path:hsa03008,Ribosome biogenesis in eukaryotes
LRRK2_HUMAN	Q5S007	LRRK2	Leucine-rich repeat serine/threonine-protein kinase 2	0.059814904	0.215849736	0.462675079	0.827364661	0.13783232	0.64501987	0.13783232	0.64501987	0.213686936497011	0.019984	-1	4.67974325615356	0.020110	1	GO:0044753,amphisome;GO:0044754,autolysosome;GO:0030424,axon;GO:0099400,caveola neck;GO:0005737,cytoplasm;GO:0032473,cytoplasmic side of mitochondrial outer membrane;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0030425,dendrite;GO:0032839,dendrite cytoplasm;GO:0005783,endoplasmic reticulum;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0098978,glutamatergic synapse;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005798,Golgi-associated vesicle;GO:0030426,growth cone;GO:0016234,inclusion body;GO:0043231,intracellular membrane-bounded organelle;GO:0005764,lysosome;GO:0045121,membrane raft;GO:0005902,microvillus;GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0031966,mitochondrial membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0097487,multivesicular body, internal vesicle;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0043204,perikaryon;GO:0005886,plasma membrane;GO:0098794,postsynapse;GO:0099523,presynaptic cytosol;GO:1990904,ribonucleoprotein complex;GO:0030672,synaptic vesicle membrane;GO:0043195,terminal bouton;GO:0005802,trans-Golgi network;GO:1990909,Wnt signalosome	GO:0003779,actin binding;GO:0005524,ATP binding;GO:1904713,beta-catenin destruction complex binding;GO:0030276,clathrin binding;GO:0039706,co-receptor binding;GO:0005525,GTP binding;GO:0034211,GTP-dependent protein kinase activity;GO:0005096,GTPase activator activity;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0044325,ion channel binding;GO:0016301,kinase activity;GO:0000287,magnesium ion binding;GO:0004708,MAP kinase kinase activity;GO:0008017,microtubule binding;GO:0036479,peroxidase inhibitor activity;GO:0042803,protein homodimerization activity;GO:0051018,protein kinase A binding;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0106311,protein threonine kinase activity;GO:0030159,signaling receptor complex adaptor activity;GO:0031267,small GTPase binding;GO:0000149,SNARE binding;GO:0017075,syntaxin-1 binding;GO:0015631,tubulin binding	GO:0000187,activation of MAPK activity;GO:0000186,activation of MAPKK activity;GO:0006914,autophagy;GO:0019722,calcium-mediated signaling;GO:0060070,canonical Wnt signaling pathway;GO:0034613,cellular protein localization;GO:1903351,cellular response to dopamine;GO:0071287,cellular response to manganese ion;GO:0071407,cellular response to organic cyclic compound;GO:0034599,cellular response to oxidative stress;GO:0009267,cellular response to starvation;GO:0008340,determination of adult lifespan;GO:0006897,endocytosis;GO:0007029,endoplasmic reticulum organization;GO:0060079,excitatory postsynaptic potential;GO:0035640,exploration behavior;GO:0007030,Golgi organization;GO:0046039,GTP metabolic process;GO:0048312,intracellular distribution of mitochondria;GO:0035556,intracellular signal transduction;GO:0035641,locomotory exploration behavior;GO:0007040,lysosome organization;GO:0000165,MAPK cascade;GO:0051646,mitochondrion localization;GO:0007005,mitochondrion organization;GO:1902902,negative regulation of autophagosome assembly;GO:1902236,negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0090394,negative regulation of excitatory postsynaptic potential;GO:0034260,negative regulation of GTPase activity;GO:1903206,negative regulation of hydrogen peroxide-induced cell death;GO:1902823,negative regulation of late endosome to lysosome transport;GO:0016242,negative regulation of macroautophagy;GO:1901215,negative regulation of neuron death;GO:0010977,negative regulation of neuron projection development;GO:0032091,negative regulation of protein binding;GO:0001933,negative regulation of protein phosphorylation;GO:0010955,negative regulation of protein processing;GO:1903217,negative regulation of protein processing involved in protein targeting to mitochondrion;GO:1903215,negative regulation of protein targeting to mitochondrion;GO:1903125,negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation;GO:0007528,neuromuscular junction development;GO:0070997,neuron death;GO:0140058,neuron projection arborization;GO:0048812,neuron projection morphogenesis;GO:0021772,olfactory bulb development;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:0016310,phosphorylation;GO:0010508,positive regulation of autophagy;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0060161,positive regulation of dopamine receptor signaling pathway;GO:1901727,positive regulation of histone deacetylase activity;GO:0043406,positive regulation of MAP kinase activity;GO:1903980,positive regulation of microglial cell activation;GO:0051770,positive regulation of nitric-oxide synthase biosynthetic process;GO:0043068,positive regulation of programmed cell death;GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1902499,positive regulation of protein autoubiquitination;GO:0032092,positive regulation of protein binding;GO:0001934,positive regulation of protein phosphorylation;GO:0031398,positive regulation of protein ubiquitination;GO:1900244,positive regulation of synaptic vesicle endocytosis;GO:0032760,positive regulation of tumor necrosis factor production;GO:0046777,protein autophosphorylation;GO:0006606,protein import into nucleus;GO:0070973,protein localization to endoplasmic reticulum exit site;GO:0070585,protein localization to mitochondrion;GO:0006468,protein phosphorylation;GO:0072593,reactive oxygen species metabolic process;GO:0010506,regulation of autophagy;GO:2000172,regulation of branching morphogenesis of a nerve;GO:1905289,regulation of CAMKK-AMPK signaling cascade;GO:0060828,regulation of canonical Wnt signaling pathway;GO:0061001,regulation of dendritic spine morphogenesis;GO:0060159,regulation of dopamine receptor signaling pathway;GO:0060628,regulation of ER to Golgi vesicle-mediated transport;GO:0035564,regulation of kidney size;GO:0040012,regulation of locomotion;GO:0035751,regulation of lysosomal lumen pH;GO:0042391,regulation of membrane potential;GO:0051900,regulation of mitochondrial depolarization;GO:0090140,regulation of mitochondrial fission;GO:1902692,regulation of neuroblast proliferation;GO:1901214,regulation of neuron death;GO:0014041,regulation of neuron maturation;GO:0010738,regulation of protein kinase A signaling;GO:0031647,regulation of protein stability;GO:1905279,regulation of retrograde transport, endosome to Golgi;GO:0051966,regulation of synaptic transmission, glutamatergic;GO:2000300,regulation of synaptic vesicle exocytosis;GO:1902803,regulation of synaptic vesicle transport;GO:0006979,response to oxidative stress;GO:0007165,signal transduction;GO:0007283,spermatogenesis;GO:0021756,striatum development;GO:0022028,tangential migration from the subventricular zone to the olfactory bulb;GO:1904887,Wnt signalosome assembly	hsa:120892,path:hsa05012,Parkinson disease
DPYD_HUMAN	Q12882	DPYD	Dihydropyrimidine dehydrogenase [NADP(+)]	0.911267763	1.643297683	1.823909808	0.926739653	1.277282723	1.3753247305	1.277282723	1.3753247305	0.928713557368843	0.457984	0	1.07675826638422	0.457840	0	GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0051539,4 iron, 4 sulfur cluster binding;GO:0017113,dihydropyrimidine dehydrogenase (NADP+) activity;GO:0050660,flavin adenine dinucleotide binding;GO:0051536,iron-sulfur cluster binding;GO:0046872,metal ion binding;GO:0050661,NADP binding;GO:0042803,protein homodimerization activity;GO:0002058,uracil binding	GO:0019483,beta-alanine biosynthetic process;GO:0006248,CMP catabolic process;GO:0006249,dCMP catabolic process;GO:0046079,dUMP catabolic process;GO:0006145,purine nucleobase catabolic process;GO:0006208,pyrimidine nucleobase catabolic process;GO:0046135,pyrimidine nucleoside catabolic process;GO:0006214,thymidine catabolic process;GO:0006210,thymine catabolic process;GO:0046050,UMP catabolic process;GO:0006212,uracil catabolic process	hsa:1806,path:hsa00240,Pyrimidine metabolism;hsa:1806,path:hsa00410,beta-Alanine metabolism;hsa:1806,path:hsa00770,Pantothenate and CoA biosynthesis;hsa:1806,path:hsa00983,Drug metabolism - other enzymes
RL18A_HUMAN	Q02543	RPL18A	60S ribosomal protein L18a	4.835356625	6.17404482	1.747879877	0.377343884	5.5047007225	1.0626118805	5.5047007225	1.0626118805	5.18034931052138	0.060062	0	0.193037175691798	0.059635	0	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0016020,membrane;GO:0042788,polysomal ribosome;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6142,path:hsa03010,Ribosome
CAPG_HUMAN	P40121	CAPG	Macrophage-capping protein	23.46336498	36.28539498	23.79574138	24.86365482	29.87437998	24.3296981	29.87437998	24.3296981	1.22789768525734	0.366593	0	0.814400101902969	0.366259	0	GO:0015629,actin cytoskeleton;GO:0005814,centriole;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0008290,F-actin capping protein complex;GO:0090543,Flemming body;GO:0030027,lamellipodium;GO:0042470,melanosome;GO:0072686,mitotic spindle;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0001726,ruffle;GO:0030054,cell junction;GO:0002102,podosome	GO:0051015,actin filament binding;GO:0045296,cadherin binding;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding;GO:0019904,protein domain specific binding;GO:0044877,protein-containing complex binding;GO:0005509,calcium ion binding	GO:0051014,actin filament severing;GO:0008154,actin polymerization or depolymerization;GO:0051016,barbed-end actin filament capping;GO:0030031,cell projection assembly;GO:0007417,central nervous system development;GO:0065003,protein-containing complex assembly	
CH10_HUMAN	P61604	HSPE1	10 kDa heat shock protein, mitochondrial	7.305641835	5.956135909	8.548104282	3.291121958	6.630888872	5.91961312	6.630888872	5.91961312	1.1201557834239	0.396088	0	0.892732970536804	0.395813	0	GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0051087,chaperone binding;GO:0046872,metal ion binding;GO:0003723,RNA binding;GO:0051082,unfolded protein binding	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0051085,chaperone cofactor-dependent protein refolding;GO:0001649,osteoblast differentiation;GO:0006457,protein folding;GO:0006986,response to unfolded protein	
PLIN3_HUMAN	O60664	PLIN3	Perilipin-3	3.726111924	5.193086477	4.064675308	4.161519527	4.4595992005	4.1130974175	4.4595992005	4.1130974175	1.08424351475988	0.406708	0	0.922302034909067	0.406455	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0005794,Golgi apparatus;GO:0005811,lipid droplet;GO:0016020,membrane;GO:0030133,transport vesicle	GO:0045296,cadherin binding	GO:0019915,lipid storage;GO:0010890,positive regulation of sequestering of triglyceride;GO:0016192,vesicle-mediated transport	
TBB6_HUMAN	Q9BUF5	TUBB6	Tubulin beta-6 chain	1.21871685	1.349342845	1.370258293	1.126194875	1.2840298475	1.248226584	1.2840298475	1.248226584	1.02868330474525	0.423995	0	0.972116486567887	0.423778	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005874,microtubule;GO:0005634,nucleus	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0005200,structural constituent of cytoskeleton	GO:0000226,microtubule cytoskeleton organization;GO:0000278,mitotic cell cycle;GO:0007017,microtubule-based process	hsa:84617,path:hsa04145,Phagosome;hsa:84617,path:hsa04540,Gap junction;hsa:84617,path:hsa05130,Pathogenic Escherichia coli infection
SBNO1_HUMAN	A3KN83	SBNO1	Protein strawberry notch homolog 1	0.341141608	0.271707941	0.39670553	3.815000826	0.3064247745	2.105853178	0.3064247745	2.105853178	0.145510987043751	0.004129	-1	6.87233328779034	0.004169	1	GO:0005634,nucleus	GO:0031490,chromatin DNA binding;GO:0042393,histone binding	GO:0006355,regulation of transcription, DNA-templated	
NCKP1_HUMAN	Q9Y2A7	NCKAP1	Nck-associated protein 1	1.830221117	1.193143071	2.082463816	4.397865917	1.511682094	3.2401648665	1.511682094	3.2401648665	0.466544807527929	0.194679	0	2.14341684628038	0.195014	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0031941,filamentous actin;GO:0005925,focal adhesion;GO:0016021,integral component of membrane;GO:0030027,lamellipodium;GO:0031258,lamellipodium membrane;GO:0001726,ruffle;GO:0031209,SCAR complex		GO:0006915,apoptotic process;GO:0016477,cell migration;GO:0000902,cell morphogenesis;GO:0030031,cell projection assembly;GO:0007417,central nervous system development;GO:0030866,cortical actin cytoskeleton organization;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0048812,neuron projection morphogenesis;GO:0030838,positive regulation of actin filament polymerization;GO:2000601,positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0010592,positive regulation of lamellipodium assembly;GO:0016601,Rac protein signal transduction;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:0016032,viral process	hsa:10787,path:hsa04810,Regulation of actin cytoskeleton;hsa:10787,path:hsa05130,Pathogenic Escherichia coli infection;hsa:10787,path:hsa05132,Salmonella infection
CSN7A_HUMAN	Q9UBW8	COPS7A	COP9 signalosome complex subunit 7a	0.334666712	0.205470163	0.351524165	0.133460481	0.2700684375	0.242492323	0.2700684375	0.242492323	1.11371953618507	0.397961	0	0.897892124102803	0.397689	0	GO:0008180,COP9 signalosome;GO:0005829,cytosol;GO:0005654,nucleoplasm		GO:0010387,COP9 signalosome assembly;GO:0000715,nucleotide-excision repair, DNA damage recognition;GO:0043687,post-translational protein modification;GO:0000338,protein deneddylation;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0016032,viral process	
TIF1B_HUMAN	Q13263	TRIM28	Transcription intermediary factor 1-beta	3.24929576	2.180846095	4.011137267	2.794364938	2.7150709275	3.4027511025	2.7150709275	3.4027511025	0.797904650006649	0.483772	0	1.25328258206249	0.483881	0	GO:0000785,chromatin;GO:0000791,euchromatin;GO:0000792,heterochromatin;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0090575,RNA polymerase II transcription regulator complex	GO:0003682,chromatin binding;GO:0070087,chromo shadow domain binding;GO:0003677,DNA binding;GO:0035851,Krueppel-associated box domain binding;GO:1990841,promoter-specific chromatin binding;GO:0004672,protein kinase activity;GO:0003723,RNA binding;GO:0019789,SUMO transferase activity;GO:0003713,transcription coactivator activity;GO:0003714,transcription corepressor activity;GO:0031625,ubiquitin protein ligase binding;GO:0004842,ubiquitin-protein transferase activity;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0006325,chromatin organization;GO:0060028,convergent extension involved in axis elongation;GO:0043045,DNA methylation involved in embryo development;GO:0006281,DNA repair;GO:0007566,embryo implantation;GO:0060669,embryonic placenta morphogenesis;GO:0001837,epithelial to mesenchymal transition;GO:0045087,innate immune response;GO:1901536,negative regulation of DNA demethylation;GO:0045869,negative regulation of single stranded viral RNA replication via double stranded DNA intermediate;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:1902187,negative regulation of viral release from host cell;GO:0043388,positive regulation of DNA binding;GO:0090309,positive regulation of DNA methylation-dependent heterochromatin assembly;GO:0045739,positive regulation of DNA repair;GO:0042307,positive regulation of protein import into nucleus;GO:0045893,positive regulation of transcription, DNA-templated;GO:0046777,protein autophosphorylation;GO:0016925,protein sumoylation;GO:0007265,Ras protein signal transduction;GO:2000653,regulation of genetic imprinting;GO:0060260,regulation of transcription initiation from RNA polymerase II promoter;GO:0016032,viral process	
ALG5_HUMAN	Q9Y673	ALG5	Dolichyl-phosphate beta-glucosyltransferase	2.17705163	0.712702951	2.285348484	7.167868829	1.4448772905	4.7266086565	1.4448772905	4.7266086565	0.305690061417083	0.065920	0	3.27128724880461	0.066171	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0004581,dolichyl-phosphate beta-glucosyltransferase activity;GO:0004576,oligosaccharyl transferase activity;GO:0016740,transferase activity	GO:0007368,determination of left/right symmetry;GO:0006486,protein glycosylation;GO:0006487,protein N-linked glycosylation;GO:0018279,protein N-linked glycosylation via asparagine	hsa:29880,path:hsa00510,N-Glycan biosynthesis
PCY1A_HUMAN	P49585	PCYT1A	Choline-phosphate cytidylyltransferase A	0.437456127	0.962230523	1.140886614	0.042059906	0.699843325	0.59147326	0.699843325	0.59147326	1.18322056520357	0.378413	0	0.845150962895874	0.378102	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0042587,glycogen granule;GO:0005634,nucleus;GO:0005635,nuclear envelope;GO:0005886,plasma membrane	GO:0004105,choline-phosphate cytidylyltransferase activity;GO:0042802,identical protein binding;GO:0031210,phosphatidylcholine binding;GO:0003824,catalytic activity;GO:0005516,calmodulin binding;GO:0042803,protein homodimerization activity	GO:0006657,CDP-choline pathway;GO:0006656,phosphatidylcholine biosynthetic process;GO:0009058,biosynthetic process;GO:0008654,phospholipid biosynthetic process	hsa:5130,path:hsa00564,Glycerophospholipid metabolism;hsa:5130,path:hsa00440,Phosphonate and phosphinate metabolism;hsa:5130,path:hsa05231,Choline metabolism in cancer
HV307_HUMAN	P01780	IGHV3-7	Immunoglobulin heavy variable 3-7	4.733446749	1.475830406	6.184312542	14.05704778	3.1046385775	10.120680161	3.1046385775	10.120680161	0.306761850795731	0.066608	0	3.2598577606897	0.066861	0	GO:0009897,external side of plasma membrane;GO:0042571,immunoglobulin complex, circulating;GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane;GO:0019814,immunoglobulin complex	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006956,complement activation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
ADT2_HUMAN	P05141	SLC25A5	ADP/ATP translocase 2	44.58441921	49.28517094	44.75643248	27.33349789	46.934795075	36.044965185	46.934795075	36.044965185	1.30211791949606	0.348136	0	0.767979600793005	0.347767	0	GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0045121,membrane raft;GO:0005743,mitochondrial inner membrane;GO:0042645,mitochondrial nucleoid;GO:0005757,mitochondrial permeability transition pore complex;GO:0005739,mitochondrion;GO:0071817,MMXD complex;GO:0005634,nucleus	GO:0000295,adenine nucleotide transmembrane transporter activity;GO:0015207,adenine transmembrane transporter activity;GO:0005471,ATP;GO:0017077,oxidative phosphorylation uncoupler activity;GO:0015078,proton transmembrane transporter activity;GO:0003723,RNA binding;GO:0031625,ubiquitin protein ligase binding	GO:1990845,adaptive thermogenesis;GO:0051503,adenine nucleotide transport;GO:0030183,B cell differentiation;GO:1990830,cellular response to leukemia inhibitory factor;GO:0007059,chromosome segregation;GO:0030218,erythrocyte differentiation;GO:0140021,mitochondrial ADP transmembrane transport;GO:1990544,mitochondrial ATP transmembrane transport;GO:1901029,negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:0008284,positive regulation of cell population proliferation;GO:1901526,positive regulation of mitophagy;GO:0046902,regulation of mitochondrial membrane permeability;GO:0016032,viral process	hsa:292,path:hsa04020,Calcium signaling pathway;hsa:292,path:hsa04022,cGMP-PKG signaling pathway;hsa:292,path:hsa04217,Necroptosis;hsa:292,path:hsa04218,Cellular senescence;hsa:292,path:hsa05012,Parkinson disease;hsa:292,path:hsa05016,Huntington disease;hsa:292,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:292,path:hsa05164,Influenza A
DDX23_HUMAN	Q9BUQ8	DDX23	Probable ATP-dependent RNA helicase DDX23	1.658106741	1.284273296	1.265029739	0.929142245	1.4711900185	1.097085992	1.4711900185	1.097085992	1.34099790647951	0.339014	0	0.745713319288674	0.338628	0	GO:0071013,catalytic step 2 spliceosome;GO:0000785,chromatin;GO:0070062,extracellular exosome;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005682,U5 snRNP	GO:0005524,ATP binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0016787,hydrolase activity;GO:0003676,nucleic acid binding	GO:0000354,cis assembly of pre-catalytic spliceosome;GO:0000398,mRNA splicing, via spliceosome;GO:0062176,R-loop disassembly;GO:0008380,RNA splicing;GO:0000375,RNA splicing, via transesterification reactions	hsa:9416,path:hsa03040,Spliceosome
NAGK_HUMAN	Q9UJ70	NAGK	N-acetyl-D-glucosamine kinase	5.505891312	4.302375411	10.30938042	5.332221872	4.9041333615	7.820801146	4.9041333615	7.820801146	0.627062786784734	0.341306	0	1.59473663734297	0.341562	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0005524,ATP binding;GO:0045127,N-acetylglucosamine kinase activity	GO:0006044,N-acetylglucosamine metabolic process;GO:0006051,N-acetylmannosamine metabolic process;GO:0019262,N-acetylneuraminate catabolic process;GO:0006048,UDP-N-acetylglucosamine biosynthetic process	hsa:55577,path:hsa00520,Amino sugar and nucleotide sugar metabolism
THOC6_HUMAN	Q86W42	THOC6	THO complex subunit 6 homolog	0.429858849	0.753038525	1.190802162	0.325193585	0.591448687	0.7579978735	0.591448687	0.7579978735	0.780277501662411	0.470176	0	1.28159532713613	0.470300	0	GO:0016604,nuclear body;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000347,THO complex;GO:0000445,THO complex part of transcription export complex;GO:0000346,transcription export complex	GO:0003723,RNA binding	GO:0006915,apoptotic process;GO:0007417,central nervous system development;GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0043066,negative regulation of apoptotic process;GO:0006405,RNA export from nucleus;GO:0008380,RNA splicing;GO:0046784,viral mRNA export from host cell nucleus	hsa:79228,path:hsa03013,RNA transport
HS90B_HUMAN	P08238	HSP90AB1	Heat shock protein HSP 90-beta	37.36598989	40.42595246	45.27555001	39.00302269	38.895971175	42.13928635	38.895971175	42.13928635	0.923033457470976	0.460036	0	1.08338434745356	0.459897	0	GO:0016324,apical plasma membrane;GO:0034751,aryl hydrocarbon receptor complex;GO:0044295,axonal growth cone;GO:0016323,basolateral plasma membrane;GO:0031526,brush border membrane;GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0044294,dendritic growth cone;GO:0120293,dynein axonemal particle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:1990565,HSP90-CDC37 chaperone complex;GO:0016234,inclusion body;GO:0005765,lysosomal membrane;GO:0042470,melanosome;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0043025,neuronal cell body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990917,ooplasm;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0034774,secretory granule lumen;GO:1990913,sperm head plasma membrane	GO:0005524,ATP binding;GO:0043008,ATP-dependent protein binding;GO:0016887,ATPase activity;GO:0045296,cadherin binding;GO:0002135,CTP binding;GO:0032564,dATP binding;GO:0097718,disordered domain specific binding;GO:0070182,DNA polymerase binding;GO:0003725,double-stranded RNA binding;GO:0005525,GTP binding;GO:0031072,heat shock protein binding;GO:0042826,histone deacetylase binding;GO:1990226,histone methyltransferase binding;GO:0042802,identical protein binding;GO:0044325,ion channel binding;GO:0019900,kinase binding;GO:0023026,MHC class II protein complex binding;GO:0030235,nitric-oxide synthase regulator activity;GO:0042277,peptide binding;GO:0046983,protein dimerization activity;GO:0044183,protein folding chaperone;GO:0042803,protein homodimerization activity;GO:0019901,protein kinase binding;GO:0019887,protein kinase regulator activity;GO:0003723,RNA binding;GO:0017098,sulfonylurea receptor binding;GO:0048156,tau protein binding;GO:0030911,TPR domain binding;GO:0031625,ubiquitin protein ligase binding;GO:0051082,unfolded protein binding;GO:0002134,UTP binding	GO:0048675,axon extension;GO:0034605,cellular response to heat;GO:0071353,cellular response to interleukin-4;GO:0071407,cellular response to organic cyclic compound;GO:0021955,central nervous system neuron axonogenesis;GO:0051131,chaperone-mediated protein complex assembly;GO:0030010,establishment of cell polarity;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0071157,negative regulation of cell cycle arrest;GO:1903660,negative regulation of complement-dependent cytotoxicity;GO:0043524,negative regulation of neuron apoptotic process;GO:1901799,negative regulation of proteasomal protein catabolic process;GO:0032435,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0051248,negative regulation of protein metabolic process;GO:1901389,negative regulation of transforming growth factor beta activation;GO:0043312,neutrophil degranulation;GO:0001890,placenta development;GO:0045597,positive regulation of cell differentiation;GO:0045793,positive regulation of cell size;GO:1904031,positive regulation of cyclin-dependent protein kinase activity;GO:0045429,positive regulation of nitric oxide biosynthetic process;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0032516,positive regulation of phosphoprotein phosphatase activity;GO:0032092,positive regulation of protein binding;GO:0042307,positive regulation of protein import into nucleus;GO:0051897,positive regulation of protein kinase B signaling;GO:2000010,positive regulation of protein localization to cell surface;GO:0071902,positive regulation of protein serine/threonine kinase activity;GO:1902949,positive regulation of tau-protein kinase activity;GO:0051973,positive regulation of telomerase activity;GO:0030511,positive regulation of transforming growth factor beta receptor signaling pathway;GO:0006457,protein folding;GO:0050821,protein stabilization;GO:0035590,purinergic nucleotide receptor signaling pathway;GO:1903827,regulation of cellular protein localization;GO:1900034,regulation of cellular response to heat;GO:0060334,regulation of interferon-gamma-mediated signaling pathway;GO:0031396,regulation of protein ubiquitination;GO:0060338,regulation of type I interferon-mediated signaling pathway;GO:0042220,response to cocaine;GO:0042493,response to drug;GO:0009651,response to salt stress;GO:0006986,response to unfolded protein;GO:0097435,supramolecular fiber organization;GO:1905323,telomerase holoenzyme complex assembly;GO:0007004,telomere maintenance via telomerase;GO:0019062,virion attachment to host cell;GO:0006805,xenobiotic metabolic process	hsa:3326,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:3326,path:hsa04151,PI3K-Akt signaling pathway;hsa:3326,path:hsa04217,Necroptosis;hsa:3326,path:hsa04621,NOD-like receptor signaling pathway;hsa:3326,path:hsa04612,Antigen processing and presentation;hsa:3326,path:hsa04659,Th17 cell differentiation;hsa:3326,path:hsa04657,IL-17 signaling pathway;hsa:3326,path:hsa04915,Estrogen signaling pathway;hsa:3326,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:3326,path:hsa05200,Pathways in cancer;hsa:3326,path:hsa05215,Prostate cancer;hsa:3326,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:3326,path:hsa05132,Salmonella infection
CCD47_HUMAN	Q96A33	CCDC47	PAT complex subunit CCDC47	0.515032301	0.496870761	0.87110524	0.579846359	0.505951531	0.7254757995	0.505951531	0.7254757995	0.697406490125106	0.402679	0	1.43388398897838	0.402877	0	GO:0005783,endoplasmic reticulum;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016020,membrane;GO:0030867,rough endoplasmic reticulum membrane;GO:0016021,integral component of membrane	GO:0005509,calcium ion binding;GO:0044183,protein folding chaperone;GO:0043022,ribosome binding;GO:0003723,RNA binding	GO:0032469,endoplasmic reticulum calcium ion homeostasis;GO:0006983,ER overload response;GO:0036503,ERAD pathway;GO:0001649,osteoblast differentiation;GO:0009791,post-embryonic development;GO:0045048,protein insertion into ER membrane;GO:0030433,ubiquitin-dependent ERAD pathway	
BET1_HUMAN	O15155	BET1	BET1 homolog	0.358172706	0.508822847	0.124313702	0.003497365	0.4334977765	0.0639055335	0.4334977765	0.0639055335	6.78341534383717	0.037416	1	0.14741836513203	0.037082	-1	GO:0005789,endoplasmic reticulum membrane;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0000139,Golgi membrane;GO:0000138,Golgi trans cisterna;GO:0030173,integral component of Golgi membrane;GO:0016020,membrane;GO:0031201,SNARE complex;GO:0030133,transport vesicle	GO:0005484,SNAP receptor activity	GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0015031,protein transport;GO:0048280,vesicle fusion with Golgi apparatus	hsa:10282,path:hsa04130,SNARE interactions in vesicular transport
ITPR3_HUMAN	Q14573	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3	0.213602037	0.288355236	1.00812216	1.361990515	0.2509786365	1.1850563375	0.2509786365	1.1850563375	0.211786248938566	0.019333	-1	4.72174187423319	0.019455	1	GO:0045177,apical part of cell;GO:0005903,brush border;GO:0005737,cytoplasm;GO:0030659,cytoplasmic vesicle membrane;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0043209,myelin sheath;GO:0043025,neuronal cell body;GO:0005640,nuclear outer membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0031095,platelet dense tubular network membrane;GO:0043235,receptor complex;GO:0016529,sarcoplasmic reticulum;GO:0030667,secretory granule membrane	GO:0005509,calcium ion binding;GO:0015278,calcium-release channel activity;GO:0043533,inositol 1,3,4,5 tetrakisphosphate binding;GO:0070679,inositol 1,4,5 trisphosphate binding;GO:0005220,inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0000822,inositol hexakisphosphate binding;GO:0035091,phosphatidylinositol binding	GO:0060402,calcium ion transport into cytosol;GO:0007186,G protein-coupled receptor signaling pathway;GO:0060291,long-term synaptic potentiation;GO:0007613,memory;GO:0030168,platelet activation;GO:0007204,positive regulation of cytosolic calcium ion concentration;GO:1903779,regulation of cardiac conduction;GO:0050796,regulation of insulin secretion;GO:0051209,release of sequestered calcium ion into cytosol;GO:0051592,response to calcium ion;GO:0050913,sensory perception of bitter taste;GO:0050916,sensory perception of sweet taste;GO:0050917,sensory perception of umami taste	hsa:3710,path:hsa04371,Apelin signaling pathway;hsa:3710,path:hsa04020,Calcium signaling pathway;hsa:3710,path:hsa04070,Phosphatidylinositol signaling system;hsa:3710,path:hsa04022,cGMP-PKG signaling pathway;hsa:3710,path:hsa04114,Oocyte meiosis;hsa:3710,path:hsa04210,Apoptosis;hsa:3710,path:hsa04218,Cellular senescence;hsa:3710,path:hsa04540,Gap junction;hsa:3710,path:hsa04611,Platelet activation;hsa:3710,path:hsa04621,NOD-like receptor signaling pathway;hsa:3710,path:hsa04625,C-type lectin receptor signaling pathway;hsa:3710,path:hsa04911,Insulin secretion;hsa:3710,path:hsa04922,Glucagon signaling pathway;hsa:3710,path:hsa04929,GnRH secretion;hsa:3710,path:hsa04912,GnRH signaling pathway;hsa:3710,path:hsa04915,Estrogen signaling pathway;hsa:3710,path:hsa04921,Oxytocin signaling pathway;hsa:3710,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:3710,path:hsa04918,Thyroid hormone synthesis;hsa:3710,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:3710,path:hsa04924,Renin secretion;hsa:3710,path:hsa04925,Aldosterone synthesis and secretion;hsa:3710,path:hsa04927,Cortisol synthesis and secretion;hsa:3710,path:hsa04270,Vascular smooth muscle contraction;hsa:3710,path:hsa04970,Salivary secretion;hsa:3710,path:hsa04971,Gastric acid secretion;hsa:3710,path:hsa04972,Pancreatic secretion;hsa:3710,path:hsa04724,Glutamatergic synapse;hsa:3710,path:hsa04725,Cholinergic synapse;hsa:3710,path:hsa04728,Dopaminergic synapse;hsa:3710,path:hsa04726,Serotonergic synapse;hsa:3710,path:hsa04720,Long-term potentiation;hsa:3710,path:hsa04730,Long-term depression;hsa:3710,path:hsa04723,Retrograde endocannabinoid signaling;hsa:3710,path:hsa04742,Taste transduction;hsa:3710,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:3710,path:hsa04713,Circadian entrainment;hsa:3710,path:hsa05205,Proteoglycans in cancer;hsa:3710,path:hsa05010,Alzheimer disease;hsa:3710,path:hsa05017,Spinocerebellar ataxia;hsa:3710,path:hsa04934,Cushing syndrome;hsa:3710,path:hsa05131,Shigellosis;hsa:3710,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3710,path:hsa05163,Human cytomegalovirus infection;hsa:3710,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection
DCPS_HUMAN	Q96C86	DCPS	m7GpppX diphosphatase	1.18257609	0.906467941	1.320278193	0.880677826	1.0445220155	1.1004780095	1.0445220155	1.1004780095	0.949153010312834	0.450712	0	1.05357090915237	0.450552	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body	GO:0042802,identical protein binding;GO:0050072,m7G(5')pppN diphosphatase activity;GO:0000340,RNA 7-methylguanosine cap binding;GO:0016787,hydrolase activity	GO:0036245,cellular response to menadione;GO:0000290,deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0043928,exonucleolytic catabolism of deadenylated mRNA;GO:0045292,mRNA cis splicing, via spliceosome;GO:0043069,negative regulation of programmed cell death;GO:0000288,nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	hsa:28960,path:hsa03018,RNA degradation
PGS1_HUMAN	P21810	BGN	Biglycan	9.252449546	18.23863291	13.26362824	128.5372589	13.745541228	70.90044357	13.745541228	70.90044357	0.193871018795941	0.013804	-1	5.15806852520104	0.013902	1	GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005796,Golgi lumen;GO:0043202,lysosomal lumen;GO:0042383,sarcolemma;GO:0030133,transport vesicle	GO:0050840,extracellular matrix binding;GO:0005201,extracellular matrix structural constituent;GO:0030021,extracellular matrix structural constituent conferring compression resistance;GO:0005539,glycosaminoglycan binding	GO:0061975,articular cartilage development;GO:0001974,blood vessel remodeling;GO:0060348,bone development;GO:0030206,chondroitin sulfate biosynthetic process;GO:0030207,chondroitin sulfate catabolic process;GO:0030208,dermatan sulfate biosynthetic process;GO:0030198,extracellular matrix organization;GO:0019800,peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan	
HV432_HUMAN	A0A087WSY4	IGHV4-30-2	Immunoglobulin heavy variable 4-30-2	2.22515788	0.412408976	0.660082913	1.748303918	1.318783428	1.2041934155	1.318783428	1.2041934155	1.09515914223167	0.403436	0	0.913109302052892	0.403176	0	GO:0009897,external side of plasma membrane;GO:0042571,immunoglobulin complex, circulating;GO:0005576,extracellular region;GO:0005886,plasma membrane	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006956,complement activation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response	
ATLA1_HUMAN	Q8WXF7	ATL1	Atlastin-1	0.098317434	0.10485831	0.060373045	0.080626994	0.101587872	0.0705000195	0.101587872	0.0705000195	1.44096232484021	0.317124	0	0.693980670251662	0.316701	0	GO:0030424,axon;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0071782,endoplasmic reticulum tubular network;GO:0098826,endoplasmic reticulum tubular network membrane;GO:0005794,Golgi apparatus;GO:0000137,Golgi cis cisterna;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding	GO:0007409,axonogenesis;GO:0007029,endoplasmic reticulum organization;GO:1990809,endoplasmic reticulum tubular network membrane organization;GO:0051260,protein homooligomerization	
DYLT1_HUMAN	P63172	DYNLT1	Dynein light chain Tctex-type 1	0.013542033	2.55E-05	0.009567383	0.011146613	0.0067837665	0.010356998	0.0067837665	0.010356998	0.654993512598921	0.366061	0	1.52673267866752	0.366295	0	GO:0044295,axonal growth cone;GO:0005868,cytoplasmic dynein complex;GO:0005881,cytoplasmic microtubule;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005794,Golgi apparatus;GO:0043657,host cell;GO:0030027,lamellipodium;GO:0005739,mitochondrion;GO:0043025,neuronal cell body;GO:0034774,secretory granule lumen;GO:0099503,secretory vesicle;GO:0005819,spindle	GO:0042802,identical protein binding;GO:0008022,protein C-terminus binding	GO:0061564,axon development;GO:0051301,cell division;GO:0016358,dendrite development;GO:0000132,establishment of mitotic spindle orientation;GO:0019060,intracellular transport of viral protein in host cell;GO:0075521,microtubule-dependent intracellular transport of viral material towards nucleus;GO:0060548,negative regulation of cell death;GO:0035795,negative regulation of mitochondrial membrane permeability;GO:0050768,negative regulation of neurogenesis;GO:0048812,neuron projection morphogenesis;GO:0043312,neutrophil degranulation;GO:0010976,positive regulation of neuron projection development;GO:0035022,positive regulation of Rac protein signal transduction;GO:0051493,regulation of cytoskeleton organization;GO:0008277,regulation of G protein-coupled receptor signaling pathway;GO:0043087,regulation of GTPase activity;GO:0046718,viral entry into host cell	hsa:6993,path:hsa05132,Salmonella infection
MYO5A_HUMAN	Q9Y4I1	MYO5A	Unconventional myosin-Va	0.245616142	0.185997362	0.259274284	0.24024572	0.215806752	0.249760002	0.215806752	0.249760002	0.864056495323058	0.482176	0	1.15733173167816	0.482087	0	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0032433,filopodium tip;GO:0030426,growth cone;GO:0032593,insulin-responsive compartment;GO:0042470,melanosome;GO:0016020,membrane;GO:0016459,myosin complex;GO:0043005,neuron projection;GO:0001726,ruffle	GO:0051015,actin filament binding;GO:0030898,actin-dependent ATPase activity;GO:0005524,ATP binding;GO:0005516,calmodulin binding;GO:0000146,microfilament motor activity;GO:0003723,RNA binding;GO:0031267,small GTPase binding;GO:0003774,motor activity	GO:0007015,actin filament organization;GO:0030048,actin filament-based movement;GO:0032869,cellular response to insulin stimulus;GO:0032402,melanosome transport;GO:0006892,post-Golgi vesicle-mediated transport;GO:0072659,protein localization to plasma membrane;GO:0015031,protein transport;GO:0030050,vesicle transport along actin filament;GO:0016192,vesicle-mediated transport	hsa:4644,path:hsa05130,Pathogenic Escherichia coli infection
EXOC4_HUMAN	Q96A65	EXOC4	Exocyst complex component 4	0.76663761	0.534655066	3.035991985	2.759103092	0.650646338	2.8975475385	0.650646338	2.8975475385	0.224550703432747	0.023948	-1	4.45333719606672	0.024089	1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0000145,exocyst;GO:0090543,Flemming body;GO:0032584,growth cone membrane;GO:0016020,membrane;GO:0005902,microvillus;GO:0035748,myelin sheath abaxonal region;GO:0005886,plasma membrane;GO:0045202,synapse	GO:0030165,PDZ domain binding;GO:0047485,protein N-terminus binding;GO:0031267,small GTPase binding	GO:0007268,chemical synaptic transmission;GO:0060271,cilium assembly;GO:0006887,exocytosis;GO:0006893,Golgi to plasma membrane transport;GO:0048341,paraxial mesoderm formation;GO:0006612,protein targeting to membrane;GO:0016241,regulation of macroautophagy;GO:0006904,vesicle docking involved in exocytosis;GO:0090522,vesicle tethering involved in exocytosis	hsa:60412,path:hsa05132,Salmonella infection
HGS_HUMAN	O14964	HGS	Hepatocyte growth factor-regulated tyrosine kinase substrate	0.258747463	0.252151528	0.259998248	0.216313029	0.2554494955	0.2381556385	0.2554494955	0.2381556385	1.07261577810596	0.410238	0	0.932300289080038	0.409992	0	GO:0005829,cytosol;GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0005768,endosome;GO:0033565,ESCRT-0 complex;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0005764,lysosome;GO:0032585,multivesicular body membrane;GO:0097013,phagocytic vesicle lumen	GO:0046872,metal ion binding;GO:0019904,protein domain specific binding;GO:0044389,ubiquitin-like protein ligase binding;GO:0016301,kinase activity	GO:0016197,endosomal transport;GO:0016236,macroautophagy;GO:0010324,membrane invagination;GO:0061024,membrane organization;GO:0044003,modulation by symbiont of host process;GO:0036258,multivesicular body assembly;GO:0016525,negative regulation of angiogenesis;GO:0008285,negative regulation of cell population proliferation;GO:0042059,negative regulation of epidermal growth factor receptor signaling pathway;GO:0010642,negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0046426,negative regulation of receptor signaling pathway via JAK-STAT;GO:0030948,negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:1903543,positive regulation of exosomal secretion;GO:0010628,positive regulation of gene expression;GO:0006892,post-Golgi vesicle-mediated transport;GO:0016579,protein deubiquitination;GO:0072657,protein localization to membrane;GO:0006622,protein targeting to lysosome;GO:0043405,regulation of MAP kinase activity;GO:0042176,regulation of protein catabolic process;GO:0007165,signal transduction;GO:0006886,intracellular protein transport	hsa:9146,path:hsa04144,Endocytosis;hsa:9146,path:hsa04145,Phagosome
TKT_HUMAN	P29401	TKT	Transketolase	32.39182326	88.30862391	57.93373429	65.35130136	60.350223585	61.642517825	60.350223585	61.642517825	0.979035667497088	0.440386	0	1.02141324693155	0.440204	0	GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0005777,peroxisome;GO:0031982,vesicle	GO:0005509,calcium ion binding;GO:0000287,magnesium ion binding;GO:0042803,protein homodimerization activity;GO:0030976,thiamine pyrophosphate binding;GO:0004802,transketolase activity;GO:0046872,metal ion binding;GO:0016740,transferase activity	GO:0046166,glyceraldehyde-3-phosphate biosynthetic process;GO:0006098,pentose-phosphate shunt;GO:0009052,pentose-phosphate shunt, non-oxidative branch;GO:0040008,regulation of growth;GO:0046390,ribose phosphate biosynthetic process;GO:0005999,xylulose biosynthetic process	hsa:7086,path:hsa00030,Pentose phosphate pathway
FHL1_HUMAN	Q13642	FHL1	Four and a half LIM domains protein 1	0.185361167	1.323834709	1.255401661	6.725980818	0.754597938	3.9906912395	0.754597938	3.9906912395	0.189089531791125	0.012514	-1	5.28850005882205	0.012605	1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0044325,ion channel binding;GO:0046872,metal ion binding	GO:0009887,animal organ morphogenesis;GO:0030154,cell differentiation;GO:0007517,muscle organ development;GO:0030308,negative regulation of cell growth;GO:2000134,negative regulation of G1/S transition of mitotic cell cycle;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0043268,positive regulation of potassium ion transport;GO:0003254,regulation of membrane depolarization;GO:1901016,regulation of potassium ion transmembrane transporter activity	hsa:2273,path:hsa04630,Jak-STAT signaling pathway
VPS39_HUMAN	Q96JC1	VPS39	Vam6/Vps39-like protein	0.034993436	0.057546714	0.08738162	2.55E-05	0.046270075	0.04370356	0.046270075	0.04370356	1.05872553631787	0.414514	0	0.944531859954841	0.414278	0	GO:0030123,AP-3 adaptor complex;GO:0005737,cytoplasm;GO:0030897,HOPS complex;GO:0005770,late endosome;GO:0031902,late endosome membrane;GO:1902501,lysosomal HOPS complex;GO:0005765,lysosomal membrane;GO:0016020,membrane		GO:0061909,autophagosome-lysosome fusion;GO:0006914,autophagy;GO:0032456,endocytic recycling;GO:0034058,endosomal vesicle fusion;GO:0008333,endosome to lysosome transport;GO:0006886,intracellular protein transport;GO:1902774,late endosome to lysosome transport	hsa:23339,path:hsa05132,Salmonella infection
OSTF1_HUMAN	Q92882	OSTF1	Osteoclast-stimulating factor 1	0.535784563	3.113015315	1.174992325	0.488009712	1.824399939	0.8315010185	1.824399939	0.8315010185	2.19410427456981	0.203227	0	0.455766852829302	0.202668	0	GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005622,intracellular anatomical structure;GO:0034774,secretory granule lumen	GO:0017124,SH3 domain binding	GO:0043312,neutrophil degranulation;GO:0001503,ossification;GO:0007165,signal transduction	
RET4_HUMAN	P02753	RBP4	Retinol-binding protein 4	0.373418389	1.281189498	0.165253911	0.100951597	0.8273039435	0.133102754	0.8273039435	0.133102754	6.21552836915756	0.043837	1	0.160887367993067	0.043472	-1	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0032991,protein-containing complex	GO:0044877,protein-containing complex binding;GO:0016918,retinal binding;GO:0019841,retinol binding;GO:0034632,retinol transmembrane transporter activity	GO:0048738,cardiac muscle tissue development;GO:0048562,embryonic organ morphogenesis;GO:0060059,embryonic retina morphogenesis in camera-type eye;GO:0048706,embryonic skeletal system development;GO:0001654,eye development;GO:0048807,female genitalia morphogenesis;GO:0006094,gluconeogenesis;GO:0042593,glucose homeostasis;GO:0007507,heart development;GO:0060347,heart trabecula formation;GO:0030324,lung development;GO:0030277,maintenance of gastrointestinal epithelium;GO:0060044,negative regulation of cardiac muscle cell proliferation;GO:0002639,positive regulation of immunoglobulin production;GO:0032024,positive regulation of insulin secretion;GO:0045471,response to ethanol;GO:0032526,response to retinoic acid;GO:0001523,retinoid metabolic process;GO:0042572,retinol metabolic process;GO:0034633,retinol transport;GO:0060157,urinary bladder development;GO:0060065,uterus development;GO:0060068,vagina development;GO:0007601,visual perception	
JIP4_HUMAN	O60271	SPAG9	C-Jun-amino-terminal kinase-interacting protein 4	0.06822889	0.206874745	0.147830608	2.55E-05	0.1375518175	0.073928054	0.1375518175	0.073928054	1.86061731720951	0.244723	0	0.53745603179689	0.244199	0	GO:0001669,acrosomal vesicle;GO:0034451,centriolar satellite;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005765,lysosomal membrane;GO:0048471,perinuclear region of cytoplasm;GO:0016021,integral component of membrane	GO:0042802,identical protein binding;GO:0008432,JUN kinase binding;GO:0019894,kinesin binding;GO:0005078,MAP-kinase scaffold activity;GO:0030159,signaling receptor complex adaptor activity	GO:0007257,activation of JUN kinase activity;GO:0032418,lysosome localization;GO:1903860,negative regulation of dendrite extension;GO:0045665,negative regulation of neuron differentiation;GO:0001933,negative regulation of protein phosphorylation;GO:0030335,positive regulation of cell migration;GO:0051149,positive regulation of muscle cell differentiation;GO:0045666,positive regulation of neuron differentiation;GO:0042147,retrograde transport, endosome to Golgi;GO:0051146,striated muscle cell differentiation;GO:0016192,vesicle-mediated transport	
FLII_HUMAN	Q13045	FLII	Protein flightless-1 homolog	1.117158595	1.124098417	1.871810647	1.527377682	1.120628506	1.6995941645	1.120628506	1.6995941645	0.659350643469452	0.369880	0	1.51664370074484	0.370110	0	GO:0015629,actin cytoskeleton;GO:0005903,brush border;GO:0034451,centriolar satellite;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding	GO:0051014,actin filament severing;GO:0008154,actin polymerization or depolymerization;GO:0051016,barbed-end actin filament capping;GO:0007275,multicellular organism development;GO:0030239,myofibril assembly;GO:0030036,actin cytoskeleton organization	
ATPK_HUMAN	P56134	ATP5MF	ATP synthase subunit f, mitochondrial	1.693901952	1.617066182	1.948202435	1.048784782	1.655484067	1.4984936085	1.655484067	1.4984936085	1.10476551759013	0.400588	0	0.90516945367859	0.400322	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005753,mitochondrial proton-transporting ATP synthase complex;GO:0005739,mitochondrion;GO:0031965,nuclear membrane;GO:0005634,nucleus;GO:0045263,proton-transporting ATP synthase complex, coupling factor F(o);GO:0000276,mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)		GO:0006754,ATP biosynthetic process;GO:0042407,cristae formation;GO:0042776,mitochondrial ATP synthesis coupled proton transport;GO:1902600,proton transmembrane transport;GO:0006811,ion transport	hsa:9551,path:hsa00190,Oxidative phosphorylation;hsa:9551,path:hsa04714,Thermogenesis
ACSL3_HUMAN	O95573	ACSL3	Long-chain-fatty-acid--CoA ligase 3	0.856880729	0.663726548	1.142397696	1.059588003	0.7603036385	1.1009928495	0.7603036385	1.1009928495	0.690561831391803	0.396857	0	1.44809625227119	0.397060	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane;GO:0005811,lipid droplet;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005778,peroxisomal membrane;GO:0005886,plasma membrane	GO:0047676,arachidonate-CoA ligase activity;GO:0005524,ATP binding;GO:0004467,long-chain fatty acid-CoA ligase activity;GO:0019904,protein domain specific binding;GO:0019901,protein kinase binding	GO:0007420,brain development;GO:0006633,fatty acid biosynthetic process;GO:0006631,fatty acid metabolic process;GO:0044539,long-chain fatty acid import into cell;GO:0001676,long-chain fatty acid metabolic process;GO:0035338,long-chain fatty-acyl-CoA biosynthetic process;GO:0035336,long-chain fatty-acyl-CoA metabolic process;GO:0030182,neuron differentiation;GO:0042998,positive regulation of Golgi to plasma membrane protein transport;GO:2001247,positive regulation of phosphatidylcholine biosynthetic process;GO:0051047,positive regulation of secretion;GO:0007584,response to nutrient;GO:0014070,response to organic cyclic compound;GO:0034379,very-low-density lipoprotein particle assembly	hsa:2181,path:hsa00061,Fatty acid biosynthesis;hsa:2181,path:hsa00071,Fatty acid degradation;hsa:2181,path:hsa04146,Peroxisome;hsa:2181,path:hsa04216,Ferroptosis;hsa:2181,path:hsa04920,Adipocytokine signaling pathway;hsa:2181,path:hsa03320,PPAR signaling pathway;hsa:2181,path:hsa04714,Thermogenesis
DPM3_HUMAN	Q9P2X0	DPM3	Dolichol-phosphate mannosyltransferase subunit 3	0.382702093	0.379821276	0.210469655	0.204322352	0.3812616845	0.2073960035	0.3812616845	0.2073960035	1.83832705580559	0.247926	0	0.543972845768613	0.247405	0	GO:0033185,dolichol-phosphate-mannose synthase complex;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0031501,mannosyltransferase complex;GO:0016020,membrane	GO:0008047,enzyme activator activity	GO:0005975,carbohydrate metabolic process;GO:0006506,GPI anchor biosynthetic process;GO:0018406,protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan;GO:0035268,protein mannosylation;GO:0018279,protein N-linked glycosylation via asparagine;GO:0035269,protein O-linked mannosylation;GO:0031647,regulation of protein stability	hsa:54344,path:hsa00510,N-Glycan biosynthesis
MYH11_HUMAN	P35749	MYH11	Myosin-11	34.03254397	23.16157352	31.15019569	114.3848462	28.597058745	72.767520945	28.597058745	72.767520945	0.392992070825315	0.130725	0	2.54458060158802	0.131047	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0042470,melanosome;GO:0005859,muscle myosin complex;GO:0032982,myosin filament;GO:0016459,myosin complex	GO:0051015,actin filament binding;GO:0005524,ATP binding;GO:0005516,calmodulin binding;GO:0003774,motor activity;GO:0008307,structural constituent of muscle	GO:0048739,cardiac muscle fiber development;GO:0048251,elastic fiber assembly;GO:0006936,muscle contraction;GO:0030241,skeletal muscle myosin thick filament assembly;GO:0006939,smooth muscle contraction	hsa:4629,path:hsa04530,Tight junction;hsa:4629,path:hsa04270,Vascular smooth muscle contraction;hsa:4629,path:hsa05130,Pathogenic Escherichia coli infection;hsa:4629,path:hsa05132,Salmonella infection
LETM1_HUMAN	O95202	LETM1	Mitochondrial proton/calcium exchanger protein	0.589054053	0.360819834	0.768585179	0.548622354	0.4749369435	0.6586037665	0.4749369435	0.6586037665	0.721126977490494	0.422577	0	1.3867183328517	0.422754	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion	GO:0005509,calcium ion binding;GO:0015369,calcium;GO:0043022,ribosome binding	GO:0099093,calcium export from the mitochondrion;GO:0006875,cellular metal ion homeostasis;GO:0042407,cristae formation;GO:0051560,mitochondrial calcium ion homeostasis;GO:0006851,mitochondrial calcium ion transmembrane transport;GO:0051562,negative regulation of mitochondrial calcium ion concentration;GO:0034214,protein hexamerization;GO:0051260,protein homooligomerization;GO:1900069,regulation of cellular hyperosmotic salinity response	
PAIRB_HUMAN	Q8NC51	SERBP1	Plasminogen activator inhibitor 1 RNA-binding protein	0.277316967	0.068939978	0.317518294	0.02224046	0.1731284725	0.169879377	0.1731284725	0.169879377	1.01912589719469	0.427079	0	0.981233037795098	0.426868	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane	GO:0045296,cadherin binding;GO:0003730,mRNA 3'-UTR binding;GO:0043022,ribosome binding;GO:0003723,RNA binding;GO:0032183,SUMO binding	GO:0030578,PML body organization;GO:0042981,regulation of apoptotic process;GO:0043488,regulation of mRNA stability	
EXOS6_HUMAN	Q5RKV6	EXOSC6	Exosome complex component MTR3	0.084303175	0.597161355	0.062208413	2.55E-05	0.340732265	0.0311169565	0.340732265	0.0311169565	10.9500511401236	0.014440	1	0.0913237744009949	0.014258	-1	GO:0000177,cytoplasmic exosome (RNase complex);GO:0005829,cytosol;GO:0000178,exosome (RNase complex);GO:0000176,nuclear exosome (RNase complex);GO:0005730,nucleolus;GO:0005654,nucleoplasm	GO:0003723,RNA binding	GO:0045006,DNA deamination;GO:0043928,exonucleolytic catabolism of deadenylated mRNA;GO:0045190,isotype switching;GO:0071028,nuclear mRNA surveillance;GO:0034427,nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5';GO:0071051,polyadenylation-dependent snoRNA 3'-end processing;GO:0045830,positive regulation of isotype switching;GO:0043488,regulation of mRNA stability;GO:0090503,RNA phosphodiester bond hydrolysis, exonucleolytic;GO:0016075,rRNA catabolic process;GO:0006364,rRNA processing;GO:0034475,U4 snRNA 3'-end processing	hsa:118460,path:hsa03018,RNA degradation
RHAG_HUMAN	Q02094	RHAG	Ammonium transporter Rh type A	0.028160053	0.036142136	0.199582189	1.834777052	0.0321510945	1.0171796205	0.0321510945	1.0171796205	0.0316080796862564	0.000000	-1	31.6374803507856	0.000000	1	GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0008519,ammonium transmembrane transporter activity;GO:0030506,ankyrin binding;GO:0022840,leak channel activity	GO:0072488,ammonium transmembrane transport;GO:0015696,ammonium transport;GO:0015701,bicarbonate transport;GO:0015670,carbon dioxide transport;GO:0006873,cellular ion homeostasis;GO:0098662,inorganic cation transmembrane transport	
ORN_HUMAN	Q9Y3B8	REXO2	Oligoribonuclease, mitochondrial	0.265519121	2.137387836	0.441688681	0.192095846	1.2014534785	0.3168922635	1.2014534785	0.3168922635	3.79136260768954	0.098325	0	0.263757414806969	0.097805	0	GO:0005925,focal adhesion;GO:0005758,mitochondrial intermembrane space;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005634,nucleus	GO:0008408,3'-5' exonuclease activity;GO:0000175,3'-5'-exoribonuclease activity;GO:0003676,nucleic acid binding	GO:0006139,nucleobase-containing compound metabolic process;GO:0009117,nucleotide metabolic process	hsa:25996,path:hsa03008,Ribosome biogenesis in eukaryotes
NHRF2_HUMAN	Q15599	SLC9A3R2	Na(+)/H(+) exchange regulatory cofactor NHE-RF2	0.423025617	0.124295923	0.24714259	1.24295801	0.27366077	0.7450503	0.27366077	0.7450503	0.367305093360811	0.110048	0	2.7225323527373	0.110356	0	GO:0016324,apical plasma membrane;GO:0012505,endomembrane system;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0008013,beta-catenin binding;GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0019902,phosphatase binding;GO:0008022,protein C-terminus binding;GO:0043495,protein-membrane adaptor activity;GO:0005102,signaling receptor binding;GO:0031799,type 2 metabotropic glutamate receptor binding;GO:0031800,type 3 metabotropic glutamate receptor binding;GO:0060090,molecular adaptor activity	GO:0072659,protein localization to plasma membrane;GO:0065003,protein-containing complex assembly	hsa:9351,path:hsa04960,Aldosterone-regulated sodium reabsorption
OLFM4_HUMAN	Q6UX06	OLFM4	Olfactomedin-4	0.081925123	0.106145137	0.056345761	1.016588835	0.09403513	0.536467298	0.09403513	0.536467298	0.175285856846394	0.009216	-1	5.70496683526678	0.009289	1	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0045171,intercellular bridge;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0042581,specific granule;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen	GO:0045296,cadherin binding;GO:0003824,catalytic activity;GO:0005198,structural molecule activity	GO:0007155,cell adhesion;GO:0043312,neutrophil degranulation;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading	
MP2K1_HUMAN	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.820243353	1.030870649	0.933848083	0.438176323	0.925557001	0.686012203	0.925557001	0.686012203	1.34918445612548	0.337138	0	0.741188497584494	0.336750	0	GO:0005829,cytosol;GO:0005769,early endosome;GO:0005783,endoplasmic reticulum;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0005770,late endosome;GO:0005815,microtubule organizing center;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0005524,ATP binding;GO:0004708,MAP kinase kinase activity;GO:0005078,MAP-kinase scaffold activity;GO:0008022,protein C-terminus binding;GO:0004672,protein kinase activity;GO:0047485,protein N-terminus binding;GO:0106310,protein serine kinase activity;GO:0043539,protein serine/threonine kinase activator activity;GO:0004674,protein serine/threonine kinase activity;GO:0004712,protein serine/threonine/tyrosine kinase activity;GO:0106311,protein threonine kinase activity;GO:0097110,scaffold protein binding;GO:0004714,transmembrane receptor protein tyrosine kinase activity	GO:0000187,activation of MAPK activity;GO:0000186,activation of MAPKK activity;GO:0060020,Bergmann glial cell differentiation;GO:0007050,cell cycle arrest;GO:0048870,cell motility;GO:0090398,cellular senescence;GO:0021697,cerebellar cortex formation;GO:0006935,chemotaxis;GO:0060502,epithelial cell proliferation involved in lung morphogenesis;GO:0070371,ERK1 and ERK2 cascade;GO:0060324,face development;GO:0007507,heart development;GO:0030216,keratinocyte differentiation;GO:0060711,labyrinthine layer development;GO:0000165,MAPK cascade;GO:0008285,negative regulation of cell population proliferation;GO:0010629,negative regulation of gene expression;GO:0030182,neuron differentiation;GO:0018107,peptidyl-threonine phosphorylation;GO:0060674,placenta blood vessel development;GO:0050772,positive regulation of axonogenesis;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0010628,positive regulation of gene expression;GO:1903800,positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:0071902,positive regulation of protein serine/threonine kinase activity;GO:0045893,positive regulation of transcription, DNA-templated;GO:0006468,protein phosphorylation;GO:0048679,regulation of axon regeneration;GO:2000641,regulation of early endosome to late endosome transport;GO:0090170,regulation of Golgi inheritance;GO:0032872,regulation of stress-activated MAPK cascade;GO:0007165,signal transduction;GO:0048538,thymus development;GO:0030878,thyroid gland development;GO:0060440,trachea formation	hsa:5604,path:hsa04014,Ras signaling pathway;hsa:5604,path:hsa04015,Rap1 signaling pathway;hsa:5604,path:hsa04010,MAPK signaling pathway;hsa:5604,path:hsa04012,ErbB signaling pathway;hsa:5604,path:hsa04370,VEGF signaling pathway;hsa:5604,path:hsa04371,Apelin signaling pathway;hsa:5604,path:hsa04668,TNF signaling pathway;hsa:5604,path:hsa04066,HIF-1 signaling pathway;hsa:5604,path:hsa04068,FoxO signaling pathway;hsa:5604,path:hsa04072,Phospholipase D signaling pathway;hsa:5604,path:hsa04071,Sphingolipid signaling pathway;hsa:5604,path:hsa04024,cAMP signaling pathway;hsa:5604,path:hsa04022,cGMP-PKG signaling pathway;hsa:5604,path:hsa04151,PI3K-Akt signaling pathway;hsa:5604,path:hsa04150,mTOR signaling pathway;hsa:5604,path:hsa04140,Autophagy - animal;hsa:5604,path:hsa04114,Oocyte meiosis;hsa:5604,path:hsa04210,Apoptosis;hsa:5604,path:hsa04218,Cellular senescence;hsa:5604,path:hsa04510,Focal adhesion;hsa:5604,path:hsa04540,Gap junction;hsa:5604,path:hsa04550,Signaling pathways regulating pluripotency of stem cells;hsa:5604,path:hsa04810,Regulation of actin cytoskeleton;hsa:5604,path:hsa04620,Toll-like receptor signaling pathway;hsa:5604,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:5604,path:hsa04660,T cell receptor signaling pathway;hsa:5604,path:hsa04662,B cell receptor signaling pathway;hsa:5604,path:hsa04664,Fc epsilon RI signaling pathway;hsa:5604,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:5604,path:hsa04062,Chemokine signaling pathway;hsa:5604,path:hsa04910,Insulin signaling pathway;hsa:5604,path:hsa04929,GnRH secretion;hsa:5604,path:hsa04912,GnRH signaling pathway;hsa:5604,path:hsa04915,Estrogen signaling pathway;hsa:5604,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:5604,path:hsa04917,Prolactin signaling pathway;hsa:5604,path:hsa04921,Oxytocin signaling pathway;hsa:5604,path:hsa04926,Relaxin signaling pathway;hsa:5604,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:5604,path:hsa04919,Thyroid hormone signaling pathway;hsa:5604,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:5604,path:hsa04916,Melanogenesis;hsa:5604,path:hsa04270,Vascular smooth muscle contraction;hsa:5604,path:hsa04725,Cholinergic synapse;hsa:5604,path:hsa04726,Serotonergic synapse;hsa:5604,path:hsa04720,Long-term potentiation;hsa:5604,path:hsa04730,Long-term depression;hsa:5604,path:hsa04722,Neurotrophin signaling pathway;hsa:5604,path:hsa04380,Osteoclast differentiation;hsa:5604,path:hsa05200,Pathways in cancer;hsa:5604,path:hsa05206,MicroRNAs in cancer;hsa:5604,path:hsa05205,Proteoglycans in cancer;hsa:5604,path:hsa05230,Central carbon metabolism in cancer;hsa:5604,path:hsa05231,Choline metabolism in cancer;hsa:5604,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:5604,path:hsa05210,Colorectal cancer;hsa:5604,path:hsa05212,Pancreatic cancer;hsa:5604,path:hsa05225,Hepatocellular carcinoma;hsa:5604,path:hsa05226,Gastric cancer;hsa:5604,path:hsa05214,Glioma;hsa:5604,path:hsa05216,Thyroid cancer;hsa:5604,path:hsa05221,Acute myeloid leukemia;hsa:5604,path:hsa05220,Chronic myeloid leukemia;hsa:5604,path:hsa05218,Melanoma;hsa:5604,path:hsa05211,Renal cell carcinoma;hsa:5604,path:hsa05219,Bladder cancer;hsa:5604,path:hsa05215,Prostate cancer;hsa:5604,path:hsa05213,Endometrial cancer;hsa:5604,path:hsa05224,Breast cancer;hsa:5604,path:hsa05223,Non-small cell lung cancer;hsa:5604,path:hsa05020,Prion diseases;hsa:5604,path:hsa05034,Alcoholism;hsa:5604,path:hsa04934,Cushing syndrome;hsa:5604,path:hsa05132,Salmonella infection;hsa:5604,path:hsa05135,Yersinia infection;hsa:5604,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:5604,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:5604,path:hsa05164,Influenza A;hsa:5604,path:hsa05161,Hepatitis B;hsa:5604,path:hsa05160,Hepatitis C;hsa:5604,path:hsa05163,Human cytomegalovirus infection;hsa:5604,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:5604,path:hsa05165,Human papillomavirus infection;hsa:5604,path:hsa01521,EGFR tyrosine kinase inhibitor resistance;hsa:5604,path:hsa01522,Endocrine resistance
DYHC1_HUMAN	Q14204	DYNC1H1	Cytoplasmic dynein 1 heavy chain 1	26.17975694	36.75758978	43.15278396	53.57200677	31.46867336	48.362395365	31.46867336	48.362395365	0.650684754601174	0.362273	0	1.53684252309389	0.362510	0	GO:1904115,axon cytoplasm;GO:0035578,azurophil granule lumen;GO:0005938,cell cortex;GO:0005813,centrosome;GO:0005868,cytoplasmic dynein complex;GO:0005881,cytoplasmic microtubule;GO:0005829,cytosol;GO:0030286,dynein complex;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0016020,membrane;GO:0005874,microtubule;GO:0005737,cytoplasm	GO:0005524,ATP binding;GO:0008569,ATP-dependent microtubule motor activity, minus-end-directed;GO:0045505,dynein intermediate chain binding;GO:0051959,dynein light intermediate chain binding;GO:0003723,RNA binding	GO:0035973,aggrephagy;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0051301,cell division;GO:0097711,ciliary basal body-plasma membrane docking;GO:0031122,cytoplasmic microtubule organization;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0051293,establishment of spindle localization;GO:0000086,G2/M transition of mitotic cell cycle;GO:0007018,microtubule-based movement;GO:0072382,minus-end-directed vesicle transport along microtubule;GO:0000278,mitotic cell cycle;GO:0007052,mitotic spindle organization;GO:0043312,neutrophil degranulation;GO:0007097,nuclear migration;GO:0033962,P-body assembly;GO:0120162,positive regulation of cold-induced thermogenesis;GO:0032388,positive regulation of intracellular transport;GO:1905832,positive regulation of spindle assembly;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0090235,regulation of metaphase plate congression;GO:0060236,regulation of mitotic spindle organization;GO:0008090,retrograde axonal transport;GO:0034063,stress granule assembly;GO:0019058,viral life cycle	hsa:1778,path:hsa04145,Phagosome;hsa:1778,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:1778,path:hsa05132,Salmonella infection
K2C80_HUMAN	Q6KB66	KRT80	Keratin, type II cytoskeletal 80	0.347070219	0.850510456	0.213510102	0.042350126	0.5987903375	0.127930114	0.5987903375	0.127930114	4.68060504894102	0.070951	0	0.21364759246804	0.070490	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005882,intermediate filament;GO:0045111,intermediate filament cytoskeleton;GO:0045095,keratin filament		GO:0070268,cornification;GO:0031424,keratinization	
CD38_HUMAN	P28907	CD38	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0.754631399	0.084052882	1.461612276	0.27591404	0.4193421405	0.868763158	0.4193421405	0.868763158	0.482688678310643	0.209316	0	2.07172872481677	0.209649	0	GO:0016323,basolateral plasma membrane;GO:0009986,cell surface;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane	GO:0042802,identical protein binding;GO:0050135,NAD(P)+ nucleosidase activity;GO:0003953,NAD+ nucleosidase activity;GO:0061809,NAD+ nucleotidase, cyclic ADP-ribose generating;GO:0016849,phosphorus-oxygen lyase activity;GO:0016740,transferase activity	GO:0097190,apoptotic signaling pathway;GO:0014824,artery smooth muscle contraction;GO:0050853,B cell receptor signaling pathway;GO:0007565,female pregnancy;GO:0060292,long-term synaptic depression;GO:0019674,NAD metabolic process;GO:0043066,negative regulation of apoptotic process;GO:0045779,negative regulation of bone resorption;GO:0010977,negative regulation of neuron projection development;GO:0045892,negative regulation of transcription, DNA-templated;GO:0030890,positive regulation of B cell proliferation;GO:0030307,positive regulation of cell growth;GO:0007204,positive regulation of cytosolic calcium ion concentration;GO:0032024,positive regulation of insulin secretion;GO:0045893,positive regulation of transcription, DNA-templated;GO:0045907,positive regulation of vasoconstriction;GO:0042493,response to drug;GO:0032355,response to estradiol;GO:0033194,response to hydroperoxide;GO:0001666,response to hypoxia;GO:0070555,response to interleukin-1;GO:0032570,response to progesterone;GO:0032526,response to retinoic acid;GO:0007165,signal transduction	hsa:952,path:hsa00760,Nicotinate and nicotinamide metabolism;hsa:952,path:hsa04020,Calcium signaling pathway;hsa:952,path:hsa04640,Hematopoietic cell lineage;hsa:952,path:hsa04921,Oxytocin signaling pathway;hsa:952,path:hsa04970,Salivary secretion;hsa:952,path:hsa04972,Pancreatic secretion
NDUB5_HUMAN	O43674	NDUFB5	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	0.170835755	2.291929253	0.021079725	2.55E-05	1.231382504	0.0105526125	1.231382504	0.0105526125	116.689824818262	0.000015	1	0.00856972749387058	0.000014	-1	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0008137,NADH dehydrogenase (ubiquinone) activity	GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly	hsa:4711,path:hsa00190,Oxidative phosphorylation;hsa:4711,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4711,path:hsa04714,Thermogenesis;hsa:4711,path:hsa05010,Alzheimer disease;hsa:4711,path:hsa05012,Parkinson disease;hsa:4711,path:hsa05016,Huntington disease;hsa:4711,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
PRDX5_HUMAN	P30044	PRDX5	Peroxiredoxin-5, mitochondrial	10.77583447	64.33178835	3.234889101	4.321324612	37.55381141	3.7781068565	37.55381141	3.7781068565	9.93984893396834	0.017710	1	0.100605150706326	0.017500	-1	GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0043231,intracellular membrane-bounded organelle;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005782,peroxisomal matrix;GO:0005777,peroxisome	GO:0016209,antioxidant activity;GO:0043027,cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0004601,peroxidase activity;GO:0051920,peroxiredoxin activity;GO:0072541,peroxynitrite reductase activity;GO:0001016,RNA polymerase III transcription regulatory region sequence-specific DNA binding;GO:0005102,signaling receptor binding;GO:0008379,thioredoxin peroxidase activity	GO:0045454,cell redox homeostasis;GO:0034599,cellular response to oxidative stress;GO:0034614,cellular response to reactive oxygen species;GO:0042744,hydrogen peroxide catabolic process;GO:0006954,inflammatory response;GO:0070995,NADPH oxidation;GO:0043066,negative regulation of apoptotic process;GO:0051354,negative regulation of oxidoreductase activity;GO:0016480,negative regulation of transcription by RNA polymerase III;GO:0032967,positive regulation of collagen biosynthetic process;GO:2001057,reactive nitrogen species metabolic process;GO:0060785,regulation of apoptosis involved in tissue homeostasis;GO:0006979,response to oxidative stress	hsa:25824,path:hsa04146,Peroxisome
DHB11_HUMAN	Q8NBQ5	HSD17B11	Estradiol 17-beta-dehydrogenase 11	0.955846692	2.530368658	3.037576175	1.657314416	1.743107675	2.3474452955	1.743107675	2.3474452955	0.742555184711439	0.440163	0	1.34670125613439	0.440321	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005811,lipid droplet	GO:0044594,17-beta-hydroxysteroid dehydrogenase (NAD+) activity;GO:0072582,17-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:0016616,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0016229,steroid dehydrogenase activity;GO:0016491,oxidoreductase activity	GO:0006710,androgen catabolic process;GO:0006703,estrogen biosynthetic process	
DCAKD_HUMAN	Q8WVC6	DCAKD	Dephospho-CoA kinase domain-containing protein	1.154789623	1.820181628	0.076621203	0.01339347	1.4874856255	0.0450073365	1.4874856255	0.0450073365	33.0498478953537	0.000916	1	0.0302573253337298	0.000894	-1	GO:0016020,membrane	GO:0005524,ATP binding;GO:0004140,dephospho-CoA kinase activity	GO:0015937,coenzyme A biosynthetic process	
THBG_HUMAN	P05543	SERPINA7	Thyroxine-binding globulin	0.094208437	0.065352316	0.083230403	0.783899871	0.0797803765	0.433565137	0.0797803765	0.433565137	0.184010128332805	0.011228	-1	5.43448346599367	0.011312	1	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0004867,serine-type endopeptidase inhibitor activity	GO:0010951,negative regulation of endopeptidase activity;GO:0070327,thyroid hormone transport	hsa:6906,path:hsa04918,Thyroid hormone synthesis
CPSF1_HUMAN	Q10570	CPSF1	Cleavage and polyadenylation specificity factor subunit 1	0.271499756	0.114564065	0.484416916	0.264683122	0.1930319105	0.374550019	0.1930319105	0.374550019	0.515370179436568	0.239262	0	1.94035285684022	0.239586	0	GO:0005847,mRNA cleavage and polyadenylation specificity factor complex;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0019899,enzyme binding;GO:0035925,mRNA 3'-UTR AU-rich region binding;GO:0003676,nucleic acid binding	GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0006378,mRNA polyadenylation;GO:0000398,mRNA splicing, via spliceosome;GO:0098789,pre-mRNA cleavage required for polyadenylation;GO:0006369,termination of RNA polymerase II transcription;GO:0006388,tRNA splicing, via endonucleolytic cleavage and ligation	hsa:29894,path:hsa03015,mRNA surveillance pathway
MDHM_HUMAN	P40926	MDH2	Malate dehydrogenase, mitochondrial	32.79732695	78.0942813	38.71934467	19.72703997	55.445804125	29.22319232	55.445804125	29.22319232	1.8973219461398	0.239580	0	0.527058679753614	0.239050	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0030060,L-malate dehydrogenase activity;GO:0046554,malate dehydrogenase (NADP+) activity;GO:0043621,protein self-association;GO:0003723,RNA binding	GO:0009060,aerobic respiration;GO:0006094,gluconeogenesis;GO:0006108,malate metabolic process;GO:0006734,NADH metabolic process;GO:0006107,oxaloacetate metabolic process;GO:0006099,tricarboxylic acid cycle;GO:0005975,carbohydrate metabolic process	hsa:4191,path:hsa00020,Citrate cycle (TCA cycle);hsa:4191,path:hsa00620,Pyruvate metabolism;hsa:4191,path:hsa00630,Glyoxylate and dicarboxylate metabolism;hsa:4191,path:hsa00270,Cysteine and methionine metabolism
GBG12_HUMAN	Q9UBI6	GNG12	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	0.180098236	0.125399725	0.132395917	0.436613089	0.1527489805	0.284504503	0.1527489805	0.284504503	0.536894772804352	0.259092	0	1.86256236911513	0.259406	0	GO:0005884,actin filament;GO:0070062,extracellular exosome;GO:0031680,G-protein beta/gamma-subunit complex;GO:0005834,heterotrimeric G-protein complex;GO:0005886,plasma membrane	GO:0031681,G-protein beta-subunit binding;GO:0030165,PDZ domain binding;GO:0042301,phosphate ion binding	GO:0021987,cerebral cortex development;GO:0007186,G protein-coupled receptor signaling pathway;GO:0032496,response to lipopolysaccharide;GO:0007165,signal transduction	hsa:55970,path:hsa04014,Ras signaling pathway;hsa:55970,path:hsa04010,MAPK signaling pathway;hsa:55970,path:hsa04371,Apelin signaling pathway;hsa:55970,path:hsa04151,PI3K-Akt signaling pathway;hsa:55970,path:hsa04810,Regulation of actin cytoskeleton;hsa:55970,path:hsa04062,Chemokine signaling pathway;hsa:55970,path:hsa04926,Relaxin signaling pathway;hsa:55970,path:hsa04724,Glutamatergic synapse;hsa:55970,path:hsa04727,GABAergic synapse;hsa:55970,path:hsa04725,Cholinergic synapse;hsa:55970,path:hsa04728,Dopaminergic synapse;hsa:55970,path:hsa04726,Serotonergic synapse;hsa:55970,path:hsa04723,Retrograde endocannabinoid signaling;hsa:55970,path:hsa04713,Circadian entrainment;hsa:55970,path:hsa05200,Pathways in cancer;hsa:55970,path:hsa05032,Morphine addiction;hsa:55970,path:hsa05034,Alcoholism;hsa:55970,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:55970,path:hsa05163,Human cytomegalovirus infection;hsa:55970,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection
APOBR_HUMAN	Q0VD83	APOBR	Apolipoprotein B receptor	2.46834747	2.166445126	4.010993354	18.72594622	2.317396298	11.368469787	2.317396298	11.368469787	0.203844170888326	0.016746	-1	4.90570809870173	0.016857	1	GO:0042627,chylomicron;GO:0034362,low-density lipoprotein particle;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0034361,very-low-density lipoprotein particle	GO:0030229,very-low-density lipoprotein particle receptor activity;GO:0030228,lipoprotein particle receptor activity	GO:0008203,cholesterol metabolic process;GO:0006869,lipid transport;GO:0006641,triglyceride metabolic process;GO:0034447,very-low-density lipoprotein particle clearance	
ARHG1_HUMAN	Q92888	ARHGEF1	Rho guanine nucleotide exchange factor 1	1.061340731	1.38114011	1.580653465	1.96074549	1.2212404205	1.7706994775	1.2212404205	1.7706994775	0.689693782608574	0.396116	0	1.44991882660995	0.396320	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005886,plasma membrane	GO:0001664,G protein-coupled receptor binding;GO:0005096,GTPase activator activity;GO:0005085,guanyl-nucleotide exchange factor activity;GO:0003723,RNA binding	GO:0007186,G protein-coupled receptor signaling pathway;GO:0043065,positive regulation of apoptotic process;GO:0043547,positive regulation of GTPase activity;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007266,Rho protein signal transduction	hsa:9138,path:hsa04810,Regulation of actin cytoskeleton;hsa:9138,path:hsa04611,Platelet activation;hsa:9138,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:9138,path:hsa04270,Vascular smooth muscle contraction;hsa:9138,path:hsa05200,Pathways in cancer;hsa:9138,path:hsa05205,Proteoglycans in cancer;hsa:9138,path:hsa05130,Pathogenic Escherichia coli infection;hsa:9138,path:hsa05135,Yersinia infection;hsa:9138,path:hsa05163,Human cytomegalovirus infection
PARP4_HUMAN	Q9UKK3	PARP4	Protein mono-ADP-ribosyltransferase PARP4	0.897196964	0.468070954	0.9265569	0.387341204	0.682633959	0.656949052	0.682633959	0.656949052	1.03909725864099	0.420672	0	0.962373821780525	0.420448	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0005876,spindle microtubule	GO:0003677,DNA binding;GO:0019899,enzyme binding;GO:0003950,NAD+ ADP-ribosyltransferase activity;GO:1990404,protein ADP-ribosylase activity	GO:0008219,cell death;GO:0006464,cellular protein modification process;GO:0006974,cellular response to DNA damage stimulus;GO:0006281,DNA repair;GO:0006954,inflammatory response;GO:0006471,protein ADP-ribosylation;GO:0140289,protein mono-ADP-ribosylation;GO:0051972,regulation of telomerase activity;GO:0042493,response to drug	hsa:143,path:hsa03410,Base excision repair;hsa:143,path:hsa04210,Apoptosis;hsa:143,path:hsa04217,Necroptosis
NU5M_HUMAN	P03915	MT-ND5	NADH-ubiquinone oxidoreductase chain 5	0.296662852	0.349333549	0.864988557	0.405155984	0.3229982005	0.6350722705	0.3229982005	0.6350722705	0.50860069869796	0.233036	0	1.96617897411475	0.233362	0	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0005750,mitochondrial respiratory chain complex III;GO:0005751,mitochondrial respiratory chain complex IV;GO:0045277,respiratory chain complex IV;GO:0005739,mitochondrion;GO:0005753,mitochondrial proton-transporting ATP synthase complex;GO:0045263,proton-transporting ATP synthase complex, coupling factor F(o);GO:0000276,mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0031305,integral component of mitochondrial inner membrane;GO:0016020,membrane;GO:0005615,extracellular space;GO:0014069,postsynaptic density;GO:0070469,respirasome;GO:0005576,extracellular region;GO:0048471,perinuclear region of cytoplasm;GO:0030425,dendrite;GO:0031966,mitochondrial membrane;GO:0043025,neuronal cell body;GO:0043005,neuron projection	GO:0008137,NADH dehydrogenase (ubiquinone) activity;GO:0048039,ubiquinone binding;GO:0004129,cytochrome-c oxidase activity;GO:0020037,heme binding;GO:0046872,metal ion binding;GO:0009055,electron transfer activity;GO:0015453,oxidoreduction-driven active transmembrane transporter activity;GO:0015078,proton transmembrane transporter activity;GO:0044877,protein-containing complex binding;GO:0008121,ubiquinol-cytochrome-c reductase activity;GO:0005507,copper ion binding;GO:0035255,ionotropic glutamate receptor binding;GO:0019901,protein kinase binding;GO:0048019,receptor antagonist activity;GO:0005102,signaling receptor binding;GO:0003954,NADH dehydrogenase activity	GO:0009060,aerobic respiration;GO:0007568,aging;GO:0021549,cerebellum development;GO:0015990,electron transport coupled proton transport;GO:0001701,in utero embryonic development;GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0045471,response to ethanol;GO:0001666,response to hypoxia;GO:0035094,response to nicotine;GO:0006123,mitochondrial electron transport, cytochrome c to oxygen;GO:0022904,respiratory electron transport chain;GO:0046688,response to copper ion;GO:0051602,response to electrical stimulus;GO:0006979,response to oxidative stress;GO:0008535,respiratory chain complex IV assembly;GO:0006754,ATP biosynthetic process;GO:0015986,ATP synthesis coupled proton transport;GO:0042407,cristae formation;GO:0042776,mitochondrial ATP synthesis coupled proton transport;GO:0055093,response to hyperoxia;GO:0031100,animal organ regeneration;GO:0042538,hyperosmotic salinity response;GO:0006122,mitochondrial electron transport, ubiquinol to cytochrome c;GO:0046686,response to cadmium ion;GO:0051592,response to calcium ion;GO:0033590,response to cobalamin;GO:0042493,response to drug;GO:0033762,response to glucagon;GO:0009408,response to heat;GO:0046689,response to mercury ion;GO:0009636,response to toxic substance;GO:0042773,ATP synthesis coupled electron transport;GO:0007595,lactation;GO:2001171,positive regulation of ATP biosynthetic process;GO:0010729,positive regulation of hydrogen peroxide biosynthetic process;GO:0010940,positive regulation of necrotic cell death;GO:0009409,response to cold;GO:0032147,activation of protein kinase activity;GO:0072522,purine-containing compound biosynthetic process;GO:0043610,regulation of carbohydrate utilization;GO:0072593,reactive oxygen species metabolic process;GO:0042220,response to cocaine;GO:0042542,response to hydrogen peroxide;GO:0006915,apoptotic process;GO:0006879,cellular iron ion homeostasis;GO:0007186,G protein-coupled receptor signaling pathway;GO:0030595,leukocyte chemotaxis;GO:0043066,negative regulation of apoptotic process;GO:1900118,negative regulation of execution phase of apoptosis;GO:0033194,response to hydroperoxide;GO:0014070,response to organic cyclic compound;GO:0071385,cellular response to glucocorticoid stimulus;GO:0009642,response to light intensity;GO:0010243,response to organonitrogen compound	hsa:4538,path:hsa00190,Oxidative phosphorylation;hsa:4538,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4538,path:hsa04714,Thermogenesis;hsa:4538,path:hsa05012,Parkinson disease;hsa:4512,path:hsa00190,Oxidative phosphorylation;hsa:4512,path:hsa04260,Cardiac muscle contraction;hsa:4512,path:hsa04714,Thermogenesis;hsa:4512,path:hsa05010,Alzheimer disease;hsa:4512,path:hsa05012,Parkinson disease;hsa:4512,path:hsa05016,Huntington disease;hsa:4512,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4514,path:hsa00190,Oxidative phosphorylation;hsa:4514,path:hsa04260,Cardiac muscle contraction;hsa:4514,path:hsa04714,Thermogenesis;hsa:4514,path:hsa05010,Alzheimer disease;hsa:4514,path:hsa05012,Parkinson disease;hsa:4514,path:hsa05016,Huntington disease;hsa:4514,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4508,path:hsa00190,Oxidative phosphorylation;hsa:4508,path:hsa04714,Thermogenesis;hsa:4508,path:hsa05010,Alzheimer disease;hsa:4508,path:hsa05012,Parkinson disease;hsa:4508,path:hsa05016,Huntington disease;hsa:4509,path:hsa00190,Oxidative phosphorylation;hsa:4509,path:hsa04714,Thermogenesis;hsa:4509,path:hsa05010,Alzheimer disease;hsa:4509,path:hsa05012,Parkinson disease;hsa:4509,path:hsa05016,Huntington disease;hsa:4519,path:hsa00190,Oxidative phosphorylation;hsa:4519,path:hsa04260,Cardiac muscle contraction;hsa:4519,path:hsa04714,Thermogenesis;hsa:4519,path:hsa05010,Alzheimer disease;hsa:4519,path:hsa05012,Parkinson disease;hsa:4519,path:hsa05016,Huntington disease;hsa:4519,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4513,path:hsa00190,Oxidative phosphorylation;hsa:4513,path:hsa04260,Cardiac muscle contraction;hsa:4513,path:hsa04714,Thermogenesis;hsa:4513,path:hsa05010,Alzheimer disease;hsa:4513,path:hsa05012,Parkinson disease;hsa:4513,path:hsa05016,Huntington disease;hsa:4513,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4536,path:hsa00190,Oxidative phosphorylation;hsa:4536,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4536,path:hsa04714,Thermogenesis;hsa:4536,path:hsa05012,Parkinson disease;hsa:4541,path:hsa00190,Oxidative phosphorylation;hsa:4541,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4541,path:hsa04714,Thermogenesis;hsa:4541,path:hsa05012,Parkinson disease;hsa:4539,path:hsa00190,Oxidative phosphorylation;hsa:4539,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4539,path:hsa04714,Thermogenesis;hsa:4539,path:hsa05012,Parkinson disease;hsa:4535,path:hsa00190,Oxidative phosphorylation;hsa:4535,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4535,path:hsa04714,Thermogenesis;hsa:4535,path:hsa05012,Parkinson disease;hsa:4537,path:hsa00190,Oxidative phosphorylation;hsa:4537,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4537,path:hsa04714,Thermogenesis;hsa:4537,path:hsa05012,Parkinson disease;hsa:4540,path:hsa00190,Oxidative phosphorylation;hsa:4540,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4540,path:hsa04714,Thermogenesis;hsa:4540,path:hsa05012,Parkinson disease
ABCA3_HUMAN	Q99758	ABCA3	Phospholipid-transporting ATPase ABCA3	0.137419514	0.254831158	5.134148672	2.342752664	0.196125336	3.738450668	0.196125336	3.738450668	0.0524616621743262	0.000013	-1	19.0615386275234	0.000014	1	GO:0097208,alveolar lamellar body;GO:0097233,alveolar lamellar body membrane;GO:0030659,cytoplasmic vesicle membrane;GO:0005615,extracellular space;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0042599,lamellar body;GO:0097232,lamellar body membrane;GO:0005770,late endosome;GO:0005765,lysosomal membrane;GO:0032585,multivesicular body membrane;GO:0005886,plasma membrane	GO:0008559,ABC-type xenobiotic transporter activity;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0042626,ATPase-coupled transmembrane transporter activity;GO:0005319,lipid transporter activity;GO:0140345,phosphatidylcholine flippase activity;GO:0120019,phosphatidylcholine transfer activity	GO:0044267,cellular protein metabolic process;GO:0046618,drug export;GO:0006855,drug transmembrane transport;GO:0006869,lipid transport;GO:0030324,lung development;GO:0070925,organelle assembly;GO:0046470,phosphatidylcholine metabolic process;GO:0046471,phosphatidylglycerol metabolic process;GO:0055091,phospholipid homeostasis;GO:0015914,phospholipid transport;GO:0010875,positive regulation of cholesterol efflux;GO:1902995,positive regulation of phospholipid efflux;GO:2001140,positive regulation of phospholipid transport;GO:0032464,positive regulation of protein homooligomerization;GO:0046890,regulation of lipid biosynthetic process;GO:0150172,regulation of phosphatidylcholine metabolic process;GO:0042493,response to drug;GO:0051384,response to glucocorticoid;GO:0043129,surfactant homeostasis;GO:0042908,xenobiotic transport	hsa:21,path:hsa02010,ABC transporters
HMCN1_HUMAN	Q96RW7	HMCN1	Hemicentin-1	0.103145384	0.294030968	0.23921036	0.989647399	0.198588176	0.6144288795	0.198588176	0.6144288795	0.323207750523712	0.077553	0	3.09398521037829	0.077823	0	GO:0005912,adherens junction;GO:0005604,basement membrane;GO:0005938,cell cortex;GO:0032154,cleavage furrow;GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome	GO:0005509,calcium ion binding;GO:0005201,extracellular matrix structural constituent	GO:0007049,cell cycle;GO:0051301,cell division;GO:0007157,heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0009617,response to bacterium;GO:0007601,visual perception	
TARA_HUMAN	Q9H2D6	TRIOBP	TRIO and F-actin-binding protein	0.096099942	0.144259524	0.167370706	0.530115443	0.120179733	0.3487430745	0.120179733	0.3487430745	0.344608228198665	0.092793	0	2.90184597514458	0.093084	0	GO:0015629,actin cytoskeleton;GO:0005737,cytoplasm;GO:0005925,focal adhesion;GO:0005815,microtubule organizing center;GO:0030496,midbody;GO:0005634,nucleus;GO:0120044,stereocilium base	GO:0051015,actin filament binding;GO:0045159,myosin II binding;GO:0031267,small GTPase binding;GO:0031625,ubiquitin protein ligase binding	GO:0007015,actin filament organization;GO:0030047,actin modification;GO:0060088,auditory receptor cell stereocilium organization;GO:0051016,barbed-end actin filament capping;GO:0007049,cell cycle;GO:0051301,cell division;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0007605,sensory perception of sound	
PPIL3_HUMAN	Q9H2H8	PPIL3	Peptidyl-prolyl cis-trans isomerase-like 3	0.244193067	3.419095611	0.037893465	0.021159805	1.831644339	0.029526635	1.831644339	0.029526635	62.0336296025605	0.000133	1	0.0161202884049642	0.000128	-1	GO:0071013,catalytic step 2 spliceosome;GO:0016021,integral component of membrane	GO:0003755,peptidyl-prolyl cis-trans isomerase activity	GO:0000398,mRNA splicing, via spliceosome;GO:0006457,protein folding;GO:0000413,protein peptidyl-prolyl isomerization	
PROD_HUMAN	O43272	PRODH	Proline dehydrogenase 1, mitochondrial	0.052369873	0.288885674	0.112659447	0.395148908	0.1706277735	0.2539041775	0.1706277735	0.2539041775	0.672016408631166	0.380909	0	1.48805890325938	0.381129	0	GO:0043231,intracellular membrane-bounded organelle;GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0071949,FAD binding;GO:0004657,proline dehydrogenase activity	GO:0019470,4-hydroxyproline catabolic process;GO:0008631,intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0010942,positive regulation of cell death;GO:0006562,proline catabolic process;GO:0010133,proline catabolic process to glutamate;GO:0006560,proline metabolic process	hsa:5625,path:hsa00330,Arginine and proline metabolism
CDC16_HUMAN	Q13042	CDC16	Cell division cycle protein 16 homolog	0.25585076	0.210869098	0.074106452	2.55E-05	0.233359929	0.037065976	0.233359929	0.037065976	6.29579884797853	0.042842	1	0.158836078494007	0.042482	-1	GO:0005680,anaphase-promoting complex;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0072686,mitotic spindle;GO:0005654,nucleoplasm		GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0051301,cell division;GO:0007091,metaphase/anaphase transition of mitotic cell cycle;GO:0045842,positive regulation of mitotic metaphase/anaphase transition;GO:0070979,protein K11-linked ubiquitination;GO:0016567,protein ubiquitination;GO:0007096,regulation of exit from mitosis;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:8881,path:hsa04120,Ubiquitin mediated proteolysis;hsa:8881,path:hsa04110,Cell cycle;hsa:8881,path:hsa04114,Oocyte meiosis;hsa:8881,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:8881,path:hsa05166,Human T-cell leukemia virus 1 infection
UBP7_HUMAN	Q93009	USP7	Ubiquitin carboxyl-terminal hydrolase 7	1.020437088	0.606463959	1.330255249	1.810664271	0.8134505235	1.57045976	0.8134505235	1.57045976	0.517969669913733	0.241655	0	1.93061497242985	0.241977	0	GO:0005694,chromosome;GO:0005829,cytosol;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016605,PML body;GO:0032991,protein-containing complex	GO:0004197,cysteine-type endopeptidase activity;GO:0101005,deubiquitinase activity;GO:1990380,Lys48-specific deubiquitinase activity;GO:0002039,p53 binding;GO:0008022,protein C-terminus binding;GO:0004843,thiol-dependent deubiquitinase;GO:0008134,transcription factor binding;GO:0031625,ubiquitin protein ligase binding	GO:0035616,histone H2B conserved C-terminal lysine deubiquitination;GO:0010216,maintenance of DNA methylation;GO:0035520,monoubiquitinated protein deubiquitination;GO:0007275,multicellular organism development;GO:0032088,negative regulation of NF-kappaB transcription factor activity;GO:0032435,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1901537,positive regulation of DNA demethylation;GO:0016579,protein deubiquitination;GO:0070536,protein K63-linked deubiquitination;GO:0050821,protein stabilization;GO:0016567,protein ubiquitination;GO:0042752,regulation of circadian rhythm;GO:0051090,regulation of DNA-binding transcription factor activity;GO:0006111,regulation of gluconeogenesis;GO:0031647,regulation of protein stability;GO:1905279,regulation of retrograde transport, endosome to Golgi;GO:1901796,regulation of signal transduction by p53 class mediator;GO:1904353,regulation of telomere capping;GO:0048511,rhythmic process;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0016032,viral process	hsa:7874,path:hsa04068,FoxO signaling pathway;hsa:7874,path:hsa05203,Viral carcinogenesis;hsa:7874,path:hsa05169,Epstein-Barr virus infection
BIRC6_HUMAN	Q9NR09	BIRC6	Baculoviral IAP repeat-containing protein 6	0.021536926	0.045261166	0.08360363	2.55E-05	0.033399046	0.041814565	0.033399046	0.041814565	0.798741921624678	0.484411	0	1.25196884366098	0.484519	0	GO:0005768,endosome;GO:0090543,Flemming body;GO:0016020,membrane;GO:0005815,microtubule organizing center;GO:0030496,midbody;GO:0005634,nucleus;GO:0000922,spindle pole;GO:0005802,trans-Golgi network	GO:0004869,cysteine-type endopeptidase inhibitor activity;GO:0061631,ubiquitin conjugating enzyme activity;GO:0004842,ubiquitin-protein transferase activity	GO:0006915,apoptotic process;GO:0007049,cell cycle;GO:0051301,cell division;GO:0060711,labyrinthine layer development;GO:0043066,negative regulation of apoptotic process;GO:2001237,negative regulation of extrinsic apoptotic signaling pathway;GO:0008284,positive regulation of cell population proliferation;GO:0006468,protein phosphorylation;GO:0016567,protein ubiquitination;GO:0042127,regulation of cell population proliferation;GO:0032465,regulation of cytokinesis;GO:0060712,spongiotrophoblast layer development;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:57448,path:hsa04120,Ubiquitin mediated proteolysis;hsa:57448,path:hsa04215,Apoptosis - multiple species
XPO2_HUMAN	P55060	CSE1L	Exportin-2	4.955077593	3.699947026	5.952453104	105.0250551	4.3275123095	55.488754102	4.3275123095	55.488754102	0.077988997582197	0.000163	-1	12.8223214940805	0.000165	1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005049,nuclear export signal receptor activity;GO:0031267,small GTPase binding	GO:0006611,protein export from nucleus;GO:0006606,protein import into nucleus	hsa:1434,path:hsa05132,Salmonella infection
KAD1_HUMAN	P00568	AK1	Adenylate kinase isoenzyme 1	2.042613442	11.47976848	1.240163988	0.84101808	6.761190961	1.040591034	6.761190961	1.040591034	6.49745263997729	0.040476	1	0.153906470029075	0.040127	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0001520,outer dense fiber;GO:0005886,plasma membrane	GO:0004017,adenylate kinase activity;GO:0005524,ATP binding;GO:0004550,nucleoside diphosphate kinase activity;GO:0019205,nucleobase-containing compound kinase activity	GO:0006172,ADP biosynthetic process;GO:0046033,AMP metabolic process;GO:0046034,ATP metabolic process;GO:0015949,nucleobase-containing small molecule interconversion;GO:0006165,nucleoside diphosphate phosphorylation;GO:0009142,nucleoside triphosphate biosynthetic process;GO:0006139,nucleobase-containing compound metabolic process;GO:0007050,cell cycle arrest	hsa:203,path:hsa00230,Purine metabolism;hsa:203,path:hsa00730,Thiamine metabolism
SRPRA_HUMAN	P08240	SRPRA	Signal recognition particle receptor subunit alpha	1.617554168	0.775303873	1.362892947	3.715638291	1.1964290205	2.539265619	1.1964290205	2.539265619	0.471171275485221	0.198859	0	2.12237046702429	0.199194	0	GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005785,signal recognition particle receptor complex	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0003723,RNA binding;GO:0005047,signal recognition particle binding	GO:0006613,cotranslational protein targeting to membrane;GO:0036498,IRE1-mediated unfolded protein response;GO:0006605,protein targeting;GO:0045047,protein targeting to ER;GO:0006614,SRP-dependent cotranslational protein targeting to membrane	hsa:6734,path:hsa03060,Protein export
EMAL3_HUMAN	Q32P44	EML3	Echinoderm microtubule-associated protein-like 3	0.110566066	2.55E-05	0.265313001	0.236728378	0.055295783	0.2510206895	0.055295783	0.2510206895	0.220283766689279	0.022342	-1	4.53959914990262	0.022477	1	GO:0005737,cytoplasm;GO:0015630,microtubule cytoskeleton;GO:0030496,midbody;GO:1990498,mitotic spindle microtubule;GO:0005634,nucleus;GO:0005819,spindle;GO:0005876,spindle microtubule;GO:0005856,cytoskeleton	GO:0008017,microtubule binding	GO:0051301,cell division;GO:0000226,microtubule cytoskeleton organization;GO:0007080,mitotic metaphase plate congression;GO:1901673,regulation of mitotic spindle assembly	
TOR1A_HUMAN	O14656	TOR1A	Torsin-1A	0.039840392	0.212013691	0.364620684	0.22480674	0.1259270415	0.294713712	0.1259270415	0.294713712	0.427285994416167	0.159840	0	2.34035286217695	0.160174	0	GO:0030659,cytoplasmic vesicle membrane;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0042406,extrinsic component of endoplasmic reticulum membrane;GO:0030426,growth cone;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0030141,secretory granule;GO:0008021,synaptic vesicle;GO:0045202,synapse	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0008092,cytoskeletal protein binding;GO:0042802,identical protein binding;GO:0019894,kinesin binding;GO:0051787,misfolded protein binding;GO:0051082,unfolded protein binding;GO:0016787,hydrolase activity	GO:0007155,cell adhesion;GO:0051085,chaperone cofactor-dependent protein refolding;GO:0061077,chaperone-mediated protein folding;GO:0072321,chaperone-mediated protein transport;GO:0071712,ER-associated misfolded protein catabolic process;GO:0045104,intermediate filament cytoskeleton organization;GO:0031175,neuron projection development;GO:0006998,nuclear envelope organization;GO:0071763,nuclear membrane organization;GO:0006996,organelle organization;GO:1900244,positive regulation of synaptic vesicle endocytosis;GO:0000338,protein deneddylation;GO:0034504,protein localization to nucleus;GO:0051584,regulation of dopamine uptake involved in synaptic transmission;GO:2000008,regulation of protein localization to cell surface;GO:0006979,response to oxidative stress;GO:0048489,synaptic vesicle transport;GO:0044319,wound healing, spreading of cells	
MTOR_HUMAN	P42345	MTOR	Serine/threonine-protein kinase mTOR	0.011798495	0.025099066	2.55E-05	2.55E-05	0.0184487805	2.55e-005	0.0184487805	2.55e-005	723.481588235294	0.000000	1	0.00138220518152948	0.000000	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0012505,endomembrane system;GO:0005789,endoplasmic reticulum membrane;GO:0098978,glutamatergic synapse;GO:0000139,Golgi membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0043025,neuronal cell body;GO:0005635,nuclear envelope;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0045335,phagocytic vesicle;GO:0016605,PML body;GO:0099524,postsynaptic cytosol;GO:0031931,TORC1 complex;GO:0031932,TORC2 complex	GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0016301,kinase activity;GO:0051219,phosphoprotein binding;GO:0019904,protein domain specific binding;GO:0004672,protein kinase activity;GO:0019901,protein kinase binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0043022,ribosome binding;GO:0001002,RNA polymerase III type 1 promoter sequence-specific DNA binding;GO:0001003,RNA polymerase III type 2 promoter sequence-specific DNA binding;GO:0001006,RNA polymerase III type 3 promoter sequence-specific DNA binding;GO:0001156,TFIIIC-class transcription factor complex binding;GO:0045182,translation regulator activity;GO:0044877,protein-containing complex binding	GO:0006207,'de novo' pyrimidine nucleobase biosynthetic process;GO:0032148,activation of protein kinase B activity;GO:0043276,anoikis;GO:0007420,brain development;GO:0055013,cardiac muscle cell development;GO:0060048,cardiac muscle contraction;GO:0007569,cell aging;GO:0007050,cell cycle arrest;GO:0034198,cellular response to amino acid starvation;GO:0071230,cellular response to amino acid stimulus;GO:0071456,cellular response to hypoxia;GO:0071233,cellular response to leucine;GO:1990253,cellular response to leucine starvation;GO:0031669,cellular response to nutrient levels;GO:0009267,cellular response to starvation;GO:0006112,energy reserve metabolic process;GO:0007281,germ cell development;GO:0003007,heart morphogenesis;GO:0003179,heart valve morphogenesis;GO:0007616,long-term memory;GO:0007040,lysosome organization;GO:0060135,maternal process involved in female pregnancy;GO:0048255,mRNA stabilization;GO:0035264,multicellular organism growth;GO:0010507,negative regulation of autophagy;GO:0070885,negative regulation of calcineurin-NFAT signaling cascade;GO:0045792,negative regulation of cell size;GO:1904193,negative regulation of cholangiocyte apoptotic process;GO:1904213,negative regulation of iodide transmembrane transport;GO:0016242,negative regulation of macroautophagy;GO:0014736,negative regulation of muscle atrophy;GO:0001933,negative regulation of protein phosphorylation;GO:0031397,negative regulation of protein ubiquitination;GO:0051647,nucleus localization;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:0016310,phosphorylation;GO:0030838,positive regulation of actin filament polymerization;GO:0061051,positive regulation of cell growth involved in cardiac muscle cell development;GO:1904056,positive regulation of cholangiocyte proliferation;GO:1904690,positive regulation of cytoplasmic translational initiation;GO:0060999,positive regulation of dendritic spine development;GO:1904000,positive regulation of eating behavior;GO:0001938,positive regulation of endothelial cell proliferation;GO:0010718,positive regulation of epithelial to mesenchymal transition;GO:0010628,positive regulation of gene expression;GO:0060252,positive regulation of glial cell proliferation;GO:1904197,positive regulation of granulosa cell proliferation;GO:0051549,positive regulation of keratinocyte migration;GO:0010592,positive regulation of lamellipodium assembly;GO:0046889,positive regulation of lipid biosynthetic process;GO:0010831,positive regulation of myotube differentiation;GO:1901216,positive regulation of neuron death;GO:0014042,positive regulation of neuron maturation;GO:0010976,positive regulation of neuron projection development;GO:0045429,positive regulation of nitric oxide biosynthetic process;GO:0048714,positive regulation of oligodendrocyte differentiation;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0032516,positive regulation of phosphoprotein phosphatase activity;GO:0051897,positive regulation of protein kinase B signaling;GO:1904058,positive regulation of sensory perception of pain;GO:1904206,positive regulation of skeletal muscle hypertrophy;GO:0048661,positive regulation of smooth muscle cell proliferation;GO:0051496,positive regulation of stress fiber assembly;GO:0045945,positive regulation of transcription by RNA polymerase III;GO:1901838,positive regulation of transcription of nucleolar large rRNA by RNA polymerase I;GO:0045727,positive regulation of translation;GO:1903691,positive regulation of wound healing, spreading of epidermal cells;GO:0009791,post-embryonic development;GO:0046777,protein autophosphorylation;GO:0030163,protein catabolic process;GO:0006468,protein phosphorylation;GO:0032956,regulation of actin cytoskeleton organization;GO:0090335,regulation of brown fat cell differentiation;GO:0043610,regulation of carbohydrate utilization;GO:0001558,regulation of cell growth;GO:0008361,regulation of cell size;GO:1900034,regulation of cellular response to heat;GO:0042752,regulation of circadian rhythm;GO:0031998,regulation of fatty acid beta-oxidation;GO:0005979,regulation of glycogen biosynthetic process;GO:0043087,regulation of GTPase activity;GO:1904059,regulation of locomotor rhythm;GO:0016241,regulation of macroautophagy;GO:0090559,regulation of membrane permeability;GO:0031641,regulation of myelination;GO:0045670,regulation of osteoclast differentiation;GO:0032095,regulation of response to food;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0099547,regulation of translation at synapse, modulating synaptic transmission;GO:0014823,response to activity;GO:0043200,response to amino acid;GO:0042220,response to cocaine;GO:0032868,response to insulin;GO:0043278,response to morphine;GO:0007584,response to nutrient;GO:0031667,response to nutrient levels;GO:0048511,rhythmic process;GO:0031529,ruffle organization;GO:0035176,social behavior;GO:0021510,spinal cord development;GO:0002296,T-helper 1 cell lineage commitment;GO:0031929,TOR signaling;GO:0038202,TORC1 signaling;GO:0008542,visual learning;GO:0050882,voluntary musculoskeletal movement;GO:0042060,wound healing	hsa:2475,path:hsa04012,ErbB signaling pathway;hsa:2475,path:hsa04371,Apelin signaling pathway;hsa:2475,path:hsa04630,Jak-STAT signaling pathway;hsa:2475,path:hsa04066,HIF-1 signaling pathway;hsa:2475,path:hsa04072,Phospholipase D signaling pathway;hsa:2475,path:hsa04151,PI3K-Akt signaling pathway;hsa:2475,path:hsa04152,AMPK signaling pathway;hsa:2475,path:hsa04150,mTOR signaling pathway;hsa:2475,path:hsa04140,Autophagy - animal;hsa:2475,path:hsa04136,Autophagy - other;hsa:2475,path:hsa04218,Cellular senescence;hsa:2475,path:hsa04659,Th17 cell differentiation;hsa:2475,path:hsa04910,Insulin signaling pathway;hsa:2475,path:hsa04920,Adipocytokine signaling pathway;hsa:2475,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:2475,path:hsa04919,Thyroid hormone signaling pathway;hsa:2475,path:hsa04211,Longevity regulating pathway;hsa:2475,path:hsa04213,Longevity regulating pathway - multiple species;hsa:2475,path:hsa04714,Thermogenesis;hsa:2475,path:hsa05200,Pathways in cancer;hsa:2475,path:hsa05206,MicroRNAs in cancer;hsa:2475,path:hsa05205,Proteoglycans in cancer;hsa:2475,path:hsa05230,Central carbon metabolism in cancer;hsa:2475,path:hsa05231,Choline metabolism in cancer;hsa:2475,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:2475,path:hsa05210,Colorectal cancer;hsa:2475,path:hsa05212,Pancreatic cancer;hsa:2475,path:hsa05225,Hepatocellular carcinoma;hsa:2475,path:hsa05226,Gastric cancer;hsa:2475,path:hsa05214,Glioma;hsa:2475,path:hsa05221,Acute myeloid leukemia;hsa:2475,path:hsa05215,Prostate cancer;hsa:2475,path:hsa05224,Breast cancer;hsa:2475,path:hsa05017,Spinocerebellar ataxia;hsa:2475,path:hsa04930,Type II diabetes mellitus;hsa:2475,path:hsa04931,Insulin resistance;hsa:2475,path:hsa05131,Shigellosis;hsa:2475,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:2475,path:hsa05168,Herpes simplex virus 1 infection;hsa:2475,path:hsa05163,Human cytomegalovirus infection;hsa:2475,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:2475,path:hsa05165,Human papillomavirus infection;hsa:2475,path:hsa01521,EGFR tyrosine kinase inhibitor resistance;hsa:2475,path:hsa01522,Endocrine resistance
NDUAA_HUMAN	O95299	NDUFA10	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	1.706857996	0.912740847	2.499065996	0.224455783	1.3097994215	1.3617608895	1.3097994215	1.3617608895	0.961842443559178	0.446283	0	1.03967131695668	0.446114	0	GO:0005737,cytoplasm;GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion	GO:0008137,NADH dehydrogenase (ubiquinone) activity	GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly	hsa:4705,path:hsa00190,Oxidative phosphorylation;hsa:4705,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4705,path:hsa04714,Thermogenesis;hsa:4705,path:hsa05010,Alzheimer disease;hsa:4705,path:hsa05012,Parkinson disease;hsa:4705,path:hsa05016,Huntington disease;hsa:4705,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
TGM2_HUMAN	P21980	TGM2	Protein-glutamine gamma-glutamyltransferase 2	24.0159748	43.32080228	48.5736347	158.7365161	33.66838854	103.6550754	33.66838854	103.6550754	0.324811770287902	0.078657	0	3.07870616607777	0.078929	0	GO:0000785,chromatin;GO:0062023,collagen-containing extracellular matrix;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005925,focal adhesion;GO:0031226,intrinsic component of plasma membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane	GO:0005509,calcium ion binding;GO:0005525,GTP binding;GO:0120297,histone dopaminyltransferase activity;GO:0120295,histone serotonyltransferase activity;GO:0042802,identical protein binding;GO:0008233,peptidase activity;GO:0120299,peptide histaminyltransferase activity;GO:0120298,peptide noradrenalinyltransferase activity;GO:0019904,protein domain specific binding;GO:0003810,protein-glutamine gamma-glutamyltransferase activity;GO:0050568,protein-glutamine glutaminase activity	GO:0043277,apoptotic cell clearance;GO:0001974,blood vessel remodeling;GO:0060348,bone development;GO:0060445,branching involved in salivary gland morphogenesis;GO:0071314,cellular response to cocaine;GO:1903351,cellular response to dopamine;GO:1904015,cellular response to serotonin;GO:0018153,isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine;GO:0032471,negative regulation of endoplasmic reticulum calcium ion concentration;GO:0018149,peptide cross-linking;GO:0007200,phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0043065,positive regulation of apoptotic process;GO:0045785,positive regulation of cell adhesion;GO:0051482,positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;GO:0043547,positive regulation of GTPase activity;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0050729,positive regulation of inflammatory response;GO:0051561,positive regulation of mitochondrial calcium ion concentration;GO:0050769,positive regulation of neurogenesis;GO:0051057,positive regulation of small GTPase mediated signal transduction;GO:0048661,positive regulation of smooth muscle cell proliferation;GO:0018277,protein deamination;GO:0051260,protein homooligomerization;GO:2000425,regulation of apoptotic cell clearance;GO:0042981,regulation of apoptotic process;GO:0060662,salivary gland cavitation	hsa:7052,path:hsa05016,Huntington disease
COR1C_HUMAN	Q9ULV4	CORO1C	Coronin-1C	4.148617201	3.815162146	6.551066825	5.926849915	3.9818896735	6.23895837	3.9818896735	6.23895837	0.638229883476527	0.351258	0	1.56683355933267	0.351505	0	GO:0015629,actin cytoskeleton;GO:0005938,cell cortex;GO:0010008,endosome membrane;GO:0016600,flotillin complex;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0016328,lateral plasma membrane;GO:0032587,ruffle membrane;GO:0042383,sarcolemma;GO:0030017,sarcomere;GO:0045202,synapse	GO:0051015,actin filament binding;GO:0031267,small GTPase binding	GO:0007015,actin filament organization;GO:0090630,activation of GTPase activity;GO:0016477,cell migration;GO:0016197,endosomal transport;GO:0140285,endosome fission;GO:0097750,endosome membrane tubulation;GO:0045184,establishment of protein localization;GO:0090148,membrane fission;GO:0010633,negative regulation of epithelial cell migration;GO:0051895,negative regulation of focal adhesion assembly;GO:0044387,negative regulation of protein kinase activity by regulation of protein phosphorylation;GO:0001933,negative regulation of protein phosphorylation;GO:1900025,negative regulation of substrate adhesion-dependent cell spreading;GO:0001755,neural crest cell migration;GO:0006909,phagocytosis;GO:2000394,positive regulation of lamellipodium morphogenesis;GO:0010632,regulation of epithelial cell migration;GO:0010762,regulation of fibroblast migration;GO:0051893,regulation of focal adhesion assembly;GO:0001932,regulation of protein phosphorylation;GO:1900027,regulation of ruffle assembly;GO:1900024,regulation of substrate adhesion-dependent cell spreading;GO:0007165,signal transduction;GO:0030036,actin cytoskeleton organization	
HNRL1_HUMAN	Q9BUJ2	HNRNPUL1	Heterogeneous nuclear ribonucleoprotein U-like protein 1	2.048607861	1.523297156	2.939851054	1.072892557	1.7859525085	2.0063718055	1.7859525085	2.0063718055	0.890140353649422	0.472193	0	1.12341834172574	0.472081	0	GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0019899,enzyme binding;GO:0003723,RNA binding	GO:0000398,mRNA splicing, via spliceosome;GO:0009615,response to virus;GO:0006396,RNA processing	hsa:11100,path:hsa05164,Influenza A
NACAM_HUMAN	E9PAV3	NACA	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	2.92116152	4.451542749	2.880113203	1.126045034	3.6863521345	2.0030791185	3.6863521345	2.0030791185	1.84034275054523	0.247634	0	0.543377041968805	0.247113	0	GO:0005737,cytoplasm;GO:0005854,nascent polypeptide-associated complex;GO:0005634,nucleus;GO:0070062,extracellular exosome	GO:0003677,DNA binding;GO:0051082,unfolded protein binding;GO:0003713,transcription coactivator activity	GO:0006612,protein targeting to membrane;GO:0003231,cardiac ventricle development;GO:0061384,heart trabecula morphogenesis;GO:0010664,negative regulation of striated muscle cell apoptotic process;GO:1901227,negative regulation of transcription from RNA polymerase II promoter involved in heart development;GO:2000138,positive regulation of cell proliferation involved in heart morphogenesis;GO:0048633,positive regulation of skeletal muscle tissue growth;GO:1901228,positive regulation of transcription from RNA polymerase II promoter involved in heart development;GO:0015031,protein transport;GO:0048742,regulation of skeletal muscle fiber development;GO:0043403,skeletal muscle tissue regeneration;GO:0006412,translation;GO:0042060,wound healing	hsa:4666,path:hsa04928,Parathyroid hormone synthesis, secretion and action
CD276_HUMAN	Q5ZPR3	CD276	CD276 antigen	0.725932504	0.483787143	0.650649465	2.649695051	0.6048598235	1.650172258	0.6048598235	1.650172258	0.366543444520808	0.109452	0	2.72818956374278	0.109760	0	GO:0009897,external side of plasma membrane;GO:0016021,integral component of membrane	GO:0005102,signaling receptor binding	GO:0032729,positive regulation of interferon-gamma production;GO:0042102,positive regulation of T cell proliferation;GO:0001817,regulation of cytokine production;GO:0050776,regulation of immune response;GO:0042110,T cell activation;GO:0050852,T cell receptor signaling pathway	hsa:80381,path:hsa04514,Cell adhesion molecules (CAMs)
ARP2_HUMAN	P61160	ACTR2	Actin-related protein 2	13.85987047	16.11818218	18.43783438	15.14431022	14.989026325	16.7910723	14.989026325	16.7910723	0.892678326743909	0.471238	0	1.1202243518643	0.471123	0	GO:0030478,actin cap;GO:0015629,actin cytoskeleton;GO:0005885,Arp2/3 protein complex;GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0016020,membrane;GO:0005634,nucleus;GO:0061825,podosome core;GO:0014069,postsynaptic density;GO:0035861,site of double-strand break	GO:0003779,actin binding;GO:0005524,ATP binding;GO:0005200,structural constituent of cytoskeleton	GO:0034314,Arp2/3 complex-mediated actin nucleation;GO:0008306,associative learning;GO:0008356,asymmetric cell division;GO:0071346,cellular response to interferon-gamma;GO:0035984,cellular response to trichostatin A;GO:0060271,cilium assembly;GO:0016482,cytosolic transport;GO:0048013,ephrin receptor signaling pathway;GO:0007163,establishment or maintenance of cell polarity;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0016344,meiotic chromosome movement towards spindle pole;GO:0033206,meiotic cytokinesis;GO:0061024,membrane organization;GO:0043312,neutrophil degranulation;GO:0061003,positive regulation of dendritic spine morphogenesis;GO:1905168,positive regulation of double-strand break repair via homologous recombination;GO:0010592,positive regulation of lamellipodium assembly;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045471,response to ethanol;GO:0035902,response to immobilization stress;GO:0051653,spindle localization	hsa:10097,path:hsa04530,Tight junction;hsa:10097,path:hsa05135,Yersinia infection
NDUBB_HUMAN	Q9NX14	NDUFB11	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial	0.714092842	2.078415188	0.081268145	0.066376066	1.396254015	0.0738221055	1.396254015	0.0738221055	18.9137658096192	0.004075	1	0.0528715439360796	0.004003	-1	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion		GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly	hsa:54539,path:hsa00190,Oxidative phosphorylation;hsa:54539,path:hsa04723,Retrograde endocannabinoid signaling;hsa:54539,path:hsa04714,Thermogenesis;hsa:54539,path:hsa05010,Alzheimer disease;hsa:54539,path:hsa05012,Parkinson disease;hsa:54539,path:hsa05016,Huntington disease;hsa:54539,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
PRS10_HUMAN	P62333	PSMC6	26S proteasome regulatory subunit 10B	3.532837079	2.50935842	4.021999155	3.136254151	3.0210977495	3.579126653	3.0210977495	3.579126653	0.844087969607819	0.490034	0	1.18471064155152	0.489961	0	GO:0005829,cytosol;GO:0031597,cytosolic proteasome complex;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0022624,proteasome accessory complex;GO:0000502,proteasome complex;GO:0008540,proteasome regulatory particle, base subcomplex;GO:0016234,inclusion body	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0042802,identical protein binding;GO:0036402,proteasome-activating ATPase activity;GO:0030674,protein-macromolecule adaptor activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0045899,positive regulation of RNA polymerase II transcription preinitiation complex assembly;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0090261,positive regulation of inclusion body assembly	hsa:5706,path:hsa03050,Proteasome;hsa:5706,path:hsa05169,Epstein-Barr virus infection
HAT1_HUMAN	O14929	HAT1	Histone acetyltransferase type B catalytic subunit	0.023065131	0.034302832	0.083142361	2.55E-05	0.0286839815	0.0415839305	0.0286839815	0.0415839305	0.689785240478891	0.396194	0	1.44972658345913	0.396398	0	GO:0000785,chromatin;GO:0000781,chromosome, telomeric region;GO:0005739,mitochondrion;GO:0016363,nuclear matrix;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0010485,H4 histone acetyltransferase activity;GO:0004402,histone acetyltransferase activity;GO:0042393,histone binding	GO:0006348,chromatin silencing at telomere;GO:0006323,DNA packaging;GO:0006335,DNA replication-dependent nucleosome assembly;GO:0006336,DNA replication-independent nucleosome assembly;GO:0043967,histone H4 acetylation;GO:0006475,internal protein amino acid acetylation;GO:0007584,response to nutrient;GO:0006325,chromatin organization	hsa:8520,path:hsa05034,Alcoholism
LY6D_HUMAN	Q14210	LY6D	Lymphocyte antigen 6D	1.407716406	0.175122034	0.101097524	0.014163722	0.79141922	0.057630623	0.79141922	0.057630623	13.7326160780875	0.008752	1	0.0728193371396767	0.008624	-1	GO:0031225,anchored component of membrane;GO:0009986,cell surface;GO:0005576,extracellular region;GO:0016020,membrane;GO:0005886,plasma membrane		GO:0007155,cell adhesion;GO:0030098,lymphocyte differentiation;GO:0035634,response to stilbenoid	
LAD1_HUMAN	O00515	LAD1	Ladinin-1	0.972459411	2.241387066	0.534801257	0.304240691	1.6069232385	0.419520974	1.6069232385	0.419520974	3.83037640091863	0.096838	0	0.261070948473934	0.096320	0	GO:0015629,actin cytoskeleton;GO:0005604,basement membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region	GO:0045296,cadherin binding;GO:0005198,structural molecule activity		
CADH1_HUMAN	P12830	CDH1	Cadherin-1	1.097793032	1.028418522	0.808634648	1.264285296	1.063105777	1.036459972	1.063105777	1.036459972	1.02570847473114	0.424951	0	0.974935885425068	0.424736	0	GO:0015629,actin cytoskeleton;GO:0005912,adherens junction;GO:0043296,apical junction complex;GO:0016342,catenin complex;GO:0030054,cell junction;GO:0005737,cytoplasm;GO:0009898,cytoplasmic side of plasma membrane;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0016600,flotillin complex;GO:0098978,glutamatergic synapse;GO:0016021,integral component of membrane;GO:0030027,lamellipodium;GO:0016328,lateral plasma membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0098794,postsynapse;GO:0005802,trans-Golgi network;GO:0016020,membrane	GO:0030506,ankyrin binding;GO:0008013,beta-catenin binding;GO:0045296,cadherin binding;GO:0005509,calcium ion binding;GO:0050839,cell adhesion molecule binding;GO:0045295,gamma-catenin binding;GO:0032794,GTPase activating protein binding;GO:0042802,identical protein binding	GO:0034332,adherens junction organization;GO:0098609,cell-cell adhesion;GO:0098742,cell-cell adhesion via plasma-membrane adhesion molecules;GO:0071681,cellular response to indole-3-methanol;GO:0071285,cellular response to lithium ion;GO:0035635,entry of bacterium into host cell;GO:0030198,extracellular matrix organization;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0030336,negative regulation of cell migration;GO:0022408,negative regulation of cell-cell adhesion;GO:0031175,neuron projection development;GO:0021983,pituitary gland development;GO:0042307,positive regulation of protein import into nucleus;GO:0045893,positive regulation of transcription, DNA-templated;GO:0072659,protein localization to plasma membrane;GO:0010468,regulation of gene expression;GO:0099576,regulation of protein catabolic process at postsynapse, modulating synaptic transmission;GO:0042493,response to drug;GO:0009636,response to toxic substance;GO:0007416,synapse assembly	hsa:999,path:hsa04015,Rap1 signaling pathway;hsa:999,path:hsa04390,Hippo signaling pathway;hsa:999,path:hsa04371,Apelin signaling pathway;hsa:999,path:hsa04514,Cell adhesion molecules (CAMs);hsa:999,path:hsa04520,Adherens junction;hsa:999,path:hsa05200,Pathways in cancer;hsa:999,path:hsa05226,Gastric cancer;hsa:999,path:hsa05216,Thyroid cancer;hsa:999,path:hsa05218,Melanoma;hsa:999,path:hsa05219,Bladder cancer;hsa:999,path:hsa05213,Endometrial cancer;hsa:999,path:hsa05100,Bacterial invasion of epithelial cells
UBA7_HUMAN	P41226	UBA7	Ubiquitin-like modifier-activating enzyme 7	0.675123012	0.960762469	1.278673071	1.390081502	0.8179427405	1.3343772865	0.8179427405	1.3343772865	0.612977115824131	0.328658	0	1.63138227216774	0.328925	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0019782,ISG15 activating enzyme activity;GO:0004842,ubiquitin-protein transferase activity	GO:0006464,cellular protein modification process;GO:0006974,cellular response to DNA damage stimulus;GO:0032020,ISG15-protein conjugation;GO:0019941,modification-dependent protein catabolic process;GO:0032480,negative regulation of type I interferon production;GO:0032446,protein modification by small protein conjugation	hsa:7318,path:hsa04120,Ubiquitin mediated proteolysis;hsa:7318,path:hsa05012,Parkinson disease
CRP_HUMAN	P02741	CRP	C-reactive protein	0.189066905	0.200444104	0.135629192	2.55E-05	0.1947555045	0.067827346	0.1947555045	0.067827346	2.87134195844844	0.145282	0	0.348269211564185	0.144716	0	GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0005509,calcium ion binding;GO:0033265,choline binding;GO:0001849,complement component C1q complex binding;GO:0042802,identical protein binding;GO:0030169,low-density lipoprotein particle binding;GO:0050750,low-density lipoprotein particle receptor binding	GO:0006953,acute-phase response;GO:0006958,complement activation, classical pathway;GO:0050830,defense response to Gram-positive bacterium;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0044793,negative regulation by host of viral process;GO:0010888,negative regulation of lipid storage;GO:0010745,negative regulation of macrophage derived foam cell differentiation;GO:0032945,negative regulation of mononuclear cell proliferation;GO:0008228,opsonization;GO:0010628,positive regulation of gene expression;GO:0032930,positive regulation of superoxide anion generation;GO:0032677,regulation of interleukin-8 production;GO:0042310,vasoconstriction	
SCFD1_HUMAN	Q8WVM8	SCFD1	Sec1 family domain-containing protein 1	1.574602241	0.773917759	2.040129821	1.359271193	1.17426	1.699700507	1.17426	1.699700507	0.690862887411023	0.397114	0	1.4474652180948	0.397317	0	GO:0005801,cis-Golgi network;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0032580,Golgi cisterna membrane;GO:0000139,Golgi membrane;GO:0005798,Golgi-associated vesicle;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0047485,protein N-terminus binding;GO:0044877,protein-containing complex binding;GO:0019905,syntaxin binding	GO:0000902,cell morphogenesis;GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:1902902,negative regulation of autophagosome assembly;GO:0006892,post-Golgi vesicle-mediated transport;GO:0060628,regulation of ER to Golgi vesicle-mediated transport;GO:0051223,regulation of protein transport;GO:0001666,response to hypoxia;GO:0009636,response to toxic substance;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:1901998,toxin transport;GO:0016192,vesicle-mediated transport;GO:0015031,protein transport	
PRP19_HUMAN	Q9UMS4	PRPF19	Pre-mRNA-processing factor 19	0.87461783	0.881699963	2.519646709	0.62836217	0.8781588965	1.5740044395	0.8781588965	1.5740044395	0.55791386254219	0.278447	0	1.79239138357918	0.278750	0	GO:0071013,catalytic step 2 spliceosome;GO:0005737,cytoplasm;GO:0005811,lipid droplet;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000974,Prp19 complex;GO:0035861,site of double-strand break;GO:0005819,spindle;GO:0071006,U2-type catalytic step 1 spliceosome;GO:0071007,U2-type catalytic step 2 spliceosome;GO:0005681,spliceosomal complex	GO:0042802,identical protein binding;GO:0061630,ubiquitin protein ligase activity;GO:0004842,ubiquitin-protein transferase activity;GO:0034450,ubiquitin-ubiquitin ligase activity	GO:0034613,cellular protein localization;GO:0006303,double-strand break repair via nonhomologous end joining;GO:0000349,generation of catalytic spliceosome for first transesterification step;GO:0001833,inner cell mass cell proliferation;GO:0008610,lipid biosynthetic process;GO:0000398,mRNA splicing, via spliceosome;GO:0048711,positive regulation of astrocyte differentiation;GO:0048026,positive regulation of mRNA splicing, via spliceosome;GO:0045666,positive regulation of neuron differentiation;GO:0010498,proteasomal protein catabolic process;GO:0070534,protein K63-linked ubiquitination;GO:0000209,protein polyubiquitination;GO:0072422,signal transduction involved in DNA damage checkpoint;GO:0000245,spliceosomal complex assembly;GO:0000244,spliceosomal tri-snRNP complex assembly;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0006281,DNA repair	hsa:27339,path:hsa03040,Spliceosome;hsa:27339,path:hsa04120,Ubiquitin mediated proteolysis
RINI_HUMAN	P13489	RNH1	Ribonuclease inhibitor	6.786935708	10.26593834	11.0455598	13.56940752	8.526437024	12.30748366	8.526437024	12.30748366	0.692784752720119	0.398752	0	1.44344978158605	0.398953	0	GO:0032311,angiogenin-PRI complex;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005737,cytoplasm	GO:0008428,ribonuclease inhibitor activity	GO:0006402,mRNA catabolic process;GO:0045765,regulation of angiogenesis	
RED_HUMAN	Q13123	IK	Protein Red	0.123119629	0.025534901	0.121592921	0.064196845	0.074327265	0.092894883	0.074327265	0.092894883	0.800122273688638	0.485463	0	1.24980897655793	0.485570	0	GO:0005694,chromosome;GO:0005737,cytoplasm;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000922,spindle pole;GO:0071005,U2-type precatalytic spliceosome	GO:0042802,identical protein binding	GO:0000278,mitotic cell cycle;GO:0007094,mitotic spindle assembly checkpoint;GO:0000398,mRNA splicing, via spliceosome;GO:0034501,protein localization to kinetochore;GO:0016032,viral process	
PTBP1_HUMAN	P26599	PTBP1	Polypyrimidine tract-binding protein 1	11.42182945	3.625467175	13.39855467	10.7329437	7.5236483125	12.065749185	7.5236483125	12.065749185	0.623554177792235	0.338165	0	1.60370988699108	0.338424	0	GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003729,mRNA binding;GO:0008187,poly-pyrimidine tract binding;GO:0036002,pre-mRNA binding;GO:0003723,RNA binding;GO:0003676,nucleic acid binding	GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0075522,IRES-dependent viral translational initiation;GO:0006397,mRNA processing;GO:0000398,mRNA splicing, via spliceosome;GO:0048025,negative regulation of mRNA splicing, via spliceosome;GO:0051148,negative regulation of muscle cell differentiation;GO:0033119,negative regulation of RNA splicing;GO:0070886,positive regulation of calcineurin-NFAT signaling cascade;GO:0035307,positive regulation of protein dephosphorylation;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0045595,regulation of cell differentiation;GO:0043484,regulation of RNA splicing;GO:0016070,RNA metabolic process;GO:0008380,RNA splicing	
A1AT_HUMAN	P01009	SERPINA1	Alpha-1-antitrypsin	56.50352418	67.25965149	82.94418795	302.4504583	61.881587835	192.697323125	61.881587835	192.697323125	0.321133614268519	0.076134	0	3.1139686272887	0.076402	0	GO:0062023,collagen-containing extracellular matrix;GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0031093,platelet alpha granule lumen	GO:0042802,identical protein binding;GO:0002020,protease binding;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0006953,acute-phase response;GO:0007596,blood coagulation;GO:0044267,cellular protein metabolic process;GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0010951,negative regulation of endopeptidase activity;GO:0043312,neutrophil degranulation;GO:0002576,platelet degranulation;GO:0043687,post-translational protein modification	hsa:5265,path:hsa04610,Complement and coagulation cascades
PPME1_HUMAN	Q9Y570	PPME1	Protein phosphatase methylesterase 1	0.90648119	1.003047996	0.844521818	1.332681321	0.954764593	1.0886015695	0.954764593	1.0886015695	0.877056050395489	0.477162	0	1.14017798468989	0.477061	0	GO:0005654,nucleoplasm	GO:0045296,cadherin binding;GO:0051722,protein C-terminal methylesterase activity;GO:0019901,protein kinase binding;GO:0051723,protein methylesterase activity;GO:0051721,protein phosphatase 2A binding;GO:0019903,protein phosphatase binding;GO:0004864,protein phosphatase inhibitor activity;GO:0019888,protein phosphatase regulator activity	GO:0000086,G2/M transition of mitotic cell cycle;GO:0006482,protein demethylation	
PABP4_HUMAN	Q13310	PABPC4	Polyadenylate-binding protein 4	1.255436113	0.314070385	1.975847731	1.165447409	0.784753249	1.57064757	0.784753249	1.57064757	0.499636751101331	0.224807	0	2.00145405196022	0.225136	0	GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex	GO:0003730,mRNA 3'-UTR binding;GO:0008143,poly(A) binding;GO:0008266,poly(U) RNA binding;GO:0003723,RNA binding	GO:0007596,blood coagulation;GO:0061515,myeloid cell development;GO:0043488,regulation of mRNA stability;GO:0006401,RNA catabolic process;GO:0006396,RNA processing;GO:0006412,translation	hsa:8761,path:hsa03013,RNA transport;hsa:8761,path:hsa03015,mRNA surveillance pathway;hsa:8761,path:hsa03018,RNA degradation
AT1A1_HUMAN	P05023	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha-1	28.74363927	10.99662391	24.34516935	29.19694429	19.87013159	26.77105682	19.87013159	26.77105682	0.742224400164715	0.439895	0	1.34730143576266	0.440053	0	GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0005901,caveola;GO:0005783,endoplasmic reticulum;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:1903561,extracellular vesicle;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane;GO:0014704,intercalated disc;GO:0016328,lateral plasma membrane;GO:0042470,melanosome;GO:0016020,membrane;GO:0045121,membrane raft;GO:0031090,organelle membrane;GO:0060342,photoreceptor inner segment membrane;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0032991,protein-containing complex;GO:0042383,sarcolemma;GO:0005890,sodium;GO:0036126,sperm flagellum;GO:0030315,T-tubule	GO:0043531,ADP binding;GO:0030506,ankyrin binding;GO:0005524,ATP binding;GO:0051087,chaperone binding;GO:0005391,P-type sodium;GO:0016791,phosphatase activity;GO:0043548,phosphatidylinositol 3-kinase binding;GO:0030955,potassium ion binding;GO:0019904,protein domain specific binding;GO:0046982,protein heterodimerization activity;GO:0019901,protein kinase binding;GO:0031402,sodium ion binding;GO:1990239,steroid hormone binding	GO:0086002,cardiac muscle cell action potential involved in contraction;GO:0086064,cell communication by electrical coupling involved in cardiac conduction;GO:0030007,cellular potassium ion homeostasis;GO:0071260,cellular response to mechanical stimulus;GO:0071383,cellular response to steroid hormone stimulus;GO:0006883,cellular sodium ion homeostasis;GO:0034220,ion transmembrane transport;GO:0060081,membrane hyperpolarization;GO:0086009,membrane repolarization;GO:0086013,membrane repolarization during cardiac muscle cell action potential;GO:0031947,negative regulation of glucocorticoid biosynthetic process;GO:0045822,negative regulation of heart contraction;GO:0045823,positive regulation of heart contraction;GO:0045989,positive regulation of striated muscle contraction;GO:1990573,potassium ion import across plasma membrane;GO:1902600,proton transmembrane transport;GO:0008217,regulation of blood pressure;GO:1903779,regulation of cardiac conduction;GO:0086004,regulation of cardiac muscle cell contraction;GO:0002028,regulation of sodium ion transport;GO:0002026,regulation of the force of heart contraction;GO:0055119,relaxation of cardiac muscle;GO:0042493,response to drug;GO:1903416,response to glycoside;GO:0036376,sodium ion export across plasma membrane	hsa:476,path:hsa04024,cAMP signaling pathway;hsa:476,path:hsa04022,cGMP-PKG signaling pathway;hsa:476,path:hsa04911,Insulin secretion;hsa:476,path:hsa04918,Thyroid hormone synthesis;hsa:476,path:hsa04919,Thyroid hormone signaling pathway;hsa:476,path:hsa04925,Aldosterone synthesis and secretion;hsa:476,path:hsa04260,Cardiac muscle contraction;hsa:476,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:476,path:hsa04970,Salivary secretion;hsa:476,path:hsa04971,Gastric acid secretion;hsa:476,path:hsa04972,Pancreatic secretion;hsa:476,path:hsa04976,Bile secretion;hsa:476,path:hsa04973,Carbohydrate digestion and absorption;hsa:476,path:hsa04974,Protein digestion and absorption;hsa:476,path:hsa04978,Mineral absorption;hsa:476,path:hsa04960,Aldosterone-regulated sodium reabsorption;hsa:476,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:476,path:hsa04964,Proximal tubule bicarbonate reclamation
CO4A1_HUMAN	P02462	COL4A1	Collagen alpha-1(IV) chain	2.271851461	3.753648005	4.159799789	39.96755124	3.012749733	22.0636755145	3.012749733	22.0636755145	0.136547953264634	0.003086	-1	7.32343455974011	0.003118	1	GO:0005604,basement membrane;GO:0005587,collagen type IV trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005581,collagen trimer;GO:0016020,membrane	GO:0005201,extracellular matrix structural constituent;GO:0030020,extracellular matrix structural constituent conferring tensile strength;GO:0048407,platelet-derived growth factor binding	GO:0071711,basement membrane organization;GO:0048514,blood vessel morphogenesis;GO:0007420,brain development;GO:0001569,branching involved in blood vessel morphogenesis;GO:0071230,cellular response to amino acid stimulus;GO:0030199,collagen fibril organization;GO:0038063,collagen-activated tyrosine kinase receptor signaling pathway;GO:0030855,epithelial cell differentiation;GO:0030198,extracellular matrix organization;GO:0007528,neuromuscular junction development;GO:0061333,renal tubule morphogenesis;GO:0061304,retinal blood vessel morphogenesis	hsa:1282,path:hsa04151,PI3K-Akt signaling pathway;hsa:1282,path:hsa04512,ECM-receptor interaction;hsa:1282,path:hsa04510,Focal adhesion;hsa:1282,path:hsa04926,Relaxin signaling pathway;hsa:1282,path:hsa04974,Protein digestion and absorption;hsa:1282,path:hsa05200,Pathways in cancer;hsa:1282,path:hsa05222,Small cell lung cancer;hsa:1282,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:1282,path:hsa05165,Human papillomavirus infection;hsa:1282,path:hsa05146,Amoebiasis
IFM2_HUMAN	Q01629	IFITM2	Interferon-induced transmembrane protein 2	1.398019711	1.780231392	0.311187404	0.472539851	1.5891255515	0.3918636275	1.5891255515	0.3918636275	4.05530250826865	0.088849	0	0.246590728548864	0.088346	0	GO:0016021,integral component of membrane;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005886,plasma membrane;GO:0032991,protein-containing complex		GO:0035458,cellular response to interferon-beta;GO:0051607,defense response to virus;GO:0006955,immune response;GO:0046597,negative regulation of viral entry into host cell;GO:0045071,negative regulation of viral genome replication;GO:0035455,response to interferon-alpha;GO:0035456,response to interferon-beta;GO:0034341,response to interferon-gamma;GO:0009615,response to virus;GO:0060337,type I interferon signaling pathway	
VPS35_HUMAN	Q96QK1	VPS35	Vacuolar protein sorting-associated protein 35	7.951067488	10.6531927	11.54711958	10.63749096	9.302130094	11.09230527	9.302130094	11.09230527	0.838611079263959	0.492222	0	1.1924478756919	0.492155	0	GO:0005829,cytosol;GO:0005769,early endosome;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0005770,late endosome;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0099073,mitochondrion-derived vesicle;GO:0030904,retromer complex;GO:0030906,retromer, cargo-selective complex;GO:0097422,tubular endosome	GO:0031748,D1 dopamine receptor binding	GO:0032456,endocytic recycling;GO:0006886,intracellular protein transport;GO:0043653,mitochondrial fragmentation involved in apoptotic process;GO:0099074,mitochondrion to lysosome transport;GO:0060548,negative regulation of cell death;GO:0050728,negative regulation of inflammatory response;GO:1902823,negative regulation of late endosome to lysosome transport;GO:1901215,negative regulation of neuron death;GO:0099639,neurotransmitter receptor transport, endosome to plasma membrane;GO:1903364,positive regulation of cellular protein catabolic process;GO:0060161,positive regulation of dopamine receptor signaling pathway;GO:0010628,positive regulation of gene expression;GO:0090141,positive regulation of mitochondrial fission;GO:0036010,protein localization to endosome;GO:0032268,regulation of cellular protein metabolic process;GO:1902950,regulation of dendritic spine maintenance;GO:0016241,regulation of macroautophagy;GO:0010821,regulation of mitochondrion organization;GO:1905606,regulation of presynapse assembly;GO:0031647,regulation of protein stability;GO:2000331,regulation of terminal button organization;GO:0042147,retrograde transport, endosome to Golgi;GO:0045056,transcytosis;GO:0016032,viral process;GO:0016055,Wnt signaling pathway	hsa:55737,path:hsa04144,Endocytosis
WDR43_HUMAN	Q15061	WDR43	WD repeat-containing protein 43	0.149724189	0.050966457	0.148349296	0.068333802	0.100345323	0.108341549	0.100345323	0.108341549	0.926194280275612	0.458892	0	1.07968708217721	0.458751	0	GO:0000785,chromatin;GO:0001650,fibrillar center;GO:0005730,nucleolus;GO:0005654,nucleoplasm	GO:0003723,RNA binding;GO:0000993,RNA polymerase II complex binding;GO:0003711,transcription elongation regulator activity	GO:2000234,positive regulation of rRNA processing;GO:0045943,positive regulation of transcription by RNA polymerase I;GO:2000036,regulation of stem cell population maintenance;GO:0034243,regulation of transcription elongation from RNA polymerase II promoter;GO:0006364,rRNA processing	hsa:23160,path:hsa03008,Ribosome biogenesis in eukaryotes
SRP72_HUMAN	O76094	SRP72	Signal recognition particle subunit SRP72	3.132489032	1.215550982	2.876568922	4.705350484	2.174020007	3.790959703	2.174020007	3.790959703	0.573474839439622	0.292732	0	1.74375566498639	0.293026	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0048500,signal recognition particle;GO:0005786,signal recognition particle, endoplasmic reticulum targeting;GO:0005737,cytoplasm	GO:0008312,7S RNA binding;GO:0003723,RNA binding;GO:0005047,signal recognition particle binding;GO:0030911,TPR domain binding	GO:0006614,SRP-dependent cotranslational protein targeting to membrane	hsa:6731,path:hsa03060,Protein export
FKBP9_HUMAN	O95302	FKBP9	Peptidyl-prolyl cis-trans isomerase FKBP9	1.413736944	1.43383603	0.968040886	1.309450213	1.423786487	1.1387455495	1.423786487	1.1387455495	1.25031135149126	0.360869	0	0.799800784666388	0.360524	0	GO:0005783,endoplasmic reticulum	GO:0005509,calcium ion binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity	GO:0006457,protein folding	
PFKAP_HUMAN	Q01813	PFKP	ATP-dependent 6-phosphofructokinase, platelet type	45.45898228	5.339260932	14.03831233	24.59812314	25.399121606	19.318217735	25.399121606	19.318217735	1.31477561514295	0.345127	0	0.760586056268831	0.344752	0	GO:0005945,6-phosphofructokinase complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005634,nucleus	GO:0003872,6-phosphofructokinase activity;GO:0016208,AMP binding;GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0070095,fructose-6-phosphate binding;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0048029,monosaccharide binding;GO:0044877,protein-containing complex binding	GO:0061621,canonical glycolysis;GO:1990830,cellular response to leukemia inhibitory factor;GO:0030388,fructose 1,6-bisphosphate metabolic process;GO:0006002,fructose 6-phosphate metabolic process	hsa:5214,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:5214,path:hsa00030,Pentose phosphate pathway;hsa:5214,path:hsa00051,Fructose and mannose metabolism;hsa:5214,path:hsa00052,Galactose metabolism;hsa:5214,path:hsa03018,RNA degradation;hsa:5214,path:hsa04066,HIF-1 signaling pathway;hsa:5214,path:hsa04152,AMPK signaling pathway;hsa:5214,path:hsa04922,Glucagon signaling pathway;hsa:5214,path:hsa04919,Thyroid hormone signaling pathway;hsa:5214,path:hsa05230,Central carbon metabolism in cancer
PIP_HUMAN	P12273	PIP	Prolactin-inducible protein	0.636529318	1.087103984	0.37487175	1.700850229	0.861816651	1.0378609895	0.861816651	1.0378609895	0.83037772853876	0.495539	0	1.20427121974927	0.495479	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005634,nucleus	GO:0003779,actin binding;GO:0004190,aspartic-type endopeptidase activity;GO:0042802,identical protein binding;GO:0019864,IgG binding	GO:0001580,detection of chemical stimulus involved in sensory perception of bitter taste;GO:0070233,negative regulation of T cell apoptotic process;GO:0010628,positive regulation of gene expression;GO:0006508,proteolysis;GO:0002682,regulation of immune system process;GO:0001895,retina homeostasis;GO:0055085,transmembrane transport	
FILA2_HUMAN	Q5D862	FLG2	Filaggrin-2	1.49825521	0.129992922	0.720723984	0.756677655	0.814124066	0.7387008195	0.814124066	0.7387008195	1.10210256237573	0.401374	0	0.907356569287315	0.401110	0	GO:0001533,cornified envelope;GO:0005737,cytoplasm;GO:0005576,extracellular region;GO:0036457,keratohyalin granule;GO:0005634,nucleus;GO:1904724,tertiary granule lumen	GO:0005509,calcium ion binding;GO:0005198,structural molecule activity;GO:0046914,transition metal ion binding	GO:0007155,cell adhesion;GO:0048730,epidermis morphogenesis;GO:0061436,establishment of skin barrier;GO:0043312,neutrophil degranulation	
PEPD_HUMAN	P12955	PEPD	Xaa-Pro dipeptidase	5.778416798	5.486189346	6.098869514	5.494913875	5.632303072	5.7968916945	5.632303072	5.7968916945	0.971607435299135	0.442920	0	1.02922225959718	0.442743	0	GO:0070062,extracellular exosome	GO:0030145,manganese ion binding;GO:0070006,metalloaminopeptidase activity;GO:0004181,metallocarboxypeptidase activity;GO:0008233,peptidase activity;GO:0102009,proline dipeptidase activity	GO:0006520,cellular amino acid metabolic process;GO:0030574,collagen catabolic process;GO:0006508,proteolysis	
OSBP1_HUMAN	P22059	OSBP	Oxysterol-binding protein 1	0.923791534	0.780514093	0.853758006	1.13415069	0.8521528135	0.993954348	0.8521528135	0.993954348	0.857335968412103	0.484800	0	1.16640387997733	0.484716	0	GO:0030054,cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0097038,perinuclear endoplasmic reticulum;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0005802,trans-Golgi network	GO:0008142,oxysterol binding;GO:0070273,phosphatidylinositol-4-phosphate binding;GO:0019904,protein domain specific binding;GO:0032934,sterol binding;GO:0120015,sterol transfer activity;GO:0015248,sterol transporter activity;GO:0008289,lipid binding	GO:0006699,bile acid biosynthetic process;GO:0032367,intracellular cholesterol transport;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:1904411,positive regulation of secretory granule organization;GO:0042531,positive regulation of tyrosine phosphorylation of STAT protein;GO:0015918,sterol transport	
UBP10_HUMAN	Q14694	USP10	Ubiquitin carboxyl-terminal hydrolase 10	0.314519759	0.047927446	0.32004958	0.127981818	0.1812236025	0.224015699	0.1812236025	0.224015699	0.808977242706548	0.492170	0	1.23612871562908	0.492270	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005769,early endosome;GO:0045111,intermediate filament cytoskeleton;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0004197,cysteine-type endopeptidase activity;GO:0044325,ion channel binding;GO:0002039,p53 binding;GO:0003723,RNA binding;GO:0004843,thiol-dependent deubiquitinase	GO:0006914,autophagy;GO:0006974,cellular response to DNA damage stimulus;GO:0071347,cellular response to interleukin-1;GO:0030330,DNA damage response, signal transduction by p53 class mediator;GO:0043124,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0016579,protein deubiquitination;GO:0010506,regulation of autophagy;GO:0019985,translesion synthesis;GO:0006511,ubiquitin-dependent protein catabolic process	
BTD_HUMAN	P43251	BTD	Biotinidase	2.55E-05	0.043107796	0.171123926	0.086473787	0.021566648	0.1287988565	0.021566648	0.1287988565	0.167444405843774	0.007617	-1	5.97213143646616	0.007681	1	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005759,mitochondrial matrix	GO:0047708,biotinidase activity;GO:0016811,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	GO:0006768,biotin metabolic process;GO:0007417,central nervous system development;GO:0006807,nitrogen compound metabolic process	hsa:686,path:hsa00780,Biotin metabolism;hsa:686,path:hsa04977,Vitamin digestion and absorption
AT131_HUMAN	Q9HD20	ATP13A1	Endoplasmic reticulum transmembrane helix translocase	1.338643402	1.202209839	1.872786645	4.487113067	1.2704266205	3.179949856	1.2704266205	3.179949856	0.399511526291187	0.136140	0	2.50305669346607	0.136465	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0005524,ATP binding;GO:0019829,ATPase-coupled cation transmembrane transporter activity;GO:0046872,metal ion binding;GO:0140567,transmembrane protein dislocase activity	GO:0006874,cellular calcium ion homeostasis;GO:0140569,extraction of mislocalized protein from ER membrane;GO:0034220,ion transmembrane transport;GO:0015031,protein transport	
SPHM_HUMAN	P51688	SGSH	N-sulphoglucosamine sulphohydrolase	0.254562007	0.292134692	0.547197937	0.847206793	0.2733483495	0.697202365	0.2733483495	0.697202365	0.392064575827995	0.129960	0	2.5506002369332	0.130282	0	GO:0070062,extracellular exosome;GO:0043202,lysosomal lumen;GO:0005764,lysosome	GO:0005539,glycosaminoglycan binding;GO:0046872,metal ion binding;GO:0008449,N-acetylglucosamine-6-sulfatase activity;GO:0016250,N-sulfoglucosamine sulfohydrolase activity;GO:0008484,sulfuric ester hydrolase activity	GO:0006027,glycosaminoglycan catabolic process;GO:0030200,heparan sulfate proteoglycan catabolic process	hsa:6448,path:hsa00531,Glycosaminoglycan degradation;hsa:6448,path:hsa04142,Lysosome
LAGE3_HUMAN	Q14657	LAGE3	EKC/KEOPS complex subunit LAGE3	0.38082048	0.558608089	0.051416476	2.55E-05	0.4697142845	0.025720988	0.4697142845	0.025720988	18.2619067549038	0.004446	1	0.0547587945454531	0.004368	-1	GO:0005737,cytoplasm;GO:0000408,EKC/KEOPS complex;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0005634,nucleus		GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0008033,tRNA processing;GO:0070525,tRNA threonylcarbamoyladenosine metabolic process	
PTPA_HUMAN	Q15257	PTPA	Serine/threonine-protein phosphatase 2A activator	2.994637932	1.618071205	4.802015044	2.795781579	2.3063545685	3.7988983115	2.3063545685	3.7988983115	0.607111425309337	0.323363	0	1.64714409630897	0.323634	0	GO:0034704,calcium channel complex;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000159,protein phosphatase type 2A complex	GO:0005524,ATP binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity;GO:0019211,phosphatase activator activity;GO:0042803,protein homodimerization activity;GO:0051721,protein phosphatase 2A binding;GO:0019888,protein phosphatase regulator activity;GO:0008160,protein tyrosine phosphatase activator activity;GO:0005102,signaling receptor binding	GO:0007052,mitotic spindle organization;GO:0032515,negative regulation of phosphoprotein phosphatase activity;GO:0035308,negative regulation of protein dephosphorylation;GO:0043065,positive regulation of apoptotic process;GO:0032516,positive regulation of phosphoprotein phosphatase activity;GO:0035307,positive regulation of protein dephosphorylation;GO:0043666,regulation of phosphoprotein phosphatase activity	hsa:5524,path:hsa04931,Insulin resistance
RB3GP_HUMAN	Q15042	RAB3GAP1	Rab3 GTPase-activating protein catalytic subunit	0.190261141	0.023287735	0.059810883	0.04432139	0.106774438	0.0520661365	0.106774438	0.0520661365	2.05074632338046	0.219703	0	0.487627352344388	0.219156	0	GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0071782,endoplasmic reticulum tubular network;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0005811,lipid droplet;GO:0098794,postsynapse;GO:0032991,protein-containing complex	GO:0005096,GTPase activator activity;GO:0031267,small GTPase binding	GO:0007420,brain development;GO:0043010,camera-type eye development;GO:0097051,establishment of protein localization to endoplasmic reticulum membrane;GO:0060079,excitatory postsynaptic potential;GO:0060325,face morphogenesis;GO:0021854,hypothalamus development;GO:0034389,lipid droplet organization;GO:2000786,positive regulation of autophagosome assembly;GO:1903373,positive regulation of endoplasmic reticulum tubular network organization;GO:0061646,positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization;GO:0043547,positive regulation of GTPase activity;GO:1903061,positive regulation of protein lipidation;GO:1903233,regulation of calcium ion-dependent exocytosis of neurotransmitter;GO:0043087,regulation of GTPase activity;GO:0048172,regulation of short-term neuronal synaptic plasticity	
MYO1E_HUMAN	Q12965	MYO1E	Unconventional myosin-Ie	0.029571903	0.034297098	0.033549361	2.55E-05	0.0319345005	0.0167874305	0.0319345005	0.0167874305	1.90228638623403	0.238896	0	0.525683202716761	0.238366	0	GO:0015629,actin cytoskeleton;GO:0005912,adherens junction;GO:0005903,brush border;GO:0030136,clathrin-coated vesicle;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0070062,extracellular exosome;GO:0005902,microvillus;GO:0016459,myosin complex;GO:0005886,plasma membrane;GO:0031982,vesicle	GO:0051015,actin filament binding;GO:0030898,actin-dependent ATPase activity;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0005516,calmodulin binding;GO:0000146,microfilament motor activity;GO:0003774,motor activity;GO:0035091,phosphatidylinositol binding;GO:0003779,actin binding	GO:0007015,actin filament organization;GO:0030048,actin filament-based movement;GO:0006897,endocytosis;GO:0032836,glomerular basement membrane development;GO:0003094,glomerular filtration;GO:0072015,glomerular visceral epithelial cell development;GO:0001701,in utero embryonic development;GO:0006807,nitrogen compound metabolic process;GO:0048008,platelet-derived growth factor receptor signaling pathway;GO:0035166,post-embryonic hemopoiesis;GO:0001570,vasculogenesis;GO:0030050,vesicle transport along actin filament	hsa:4643,path:hsa05130,Pathogenic Escherichia coli infection
RPR1B_HUMAN	Q9NQG5	RPRD1B	Regulation of nuclear pre-mRNA domain-containing protein 1B	0.370772279	0.143372812	0.867742857	0.219430434	0.2570725455	0.5435866455	0.2570725455	0.5435866455	0.472919170528077	0.200442	0	2.11452624955628	0.200776	0	GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016591,RNA polymerase II, holoenzyme	GO:0042802,identical protein binding;GO:0000993,RNA polymerase II complex binding	GO:0070940,dephosphorylation of RNA polymerase II C-terminal domain;GO:0031124,mRNA 3'-end processing;GO:0008284,positive regulation of cell population proliferation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0010564,regulation of cell cycle process;GO:0042795,snRNA transcription by RNA polymerase II	
TNAP2_HUMAN	Q03169	TNFAIP2	Tumor necrosis factor alpha-induced protein 2	1.639600668	0.918670786	1.7742801	1.428337315	1.279135727	1.6013087075	1.279135727	1.6013087075	0.798806451878362	0.484460	0	1.25186770543545	0.484568	0	GO:0000145,exocyst;GO:0005615,extracellular space	GO:0000149,SNARE binding	GO:0001525,angiogenesis;GO:0030154,cell differentiation;GO:0051601,exocyst localization;GO:0006887,exocytosis	
KRT84_HUMAN	Q9NSB2	KRT84	Keratin, type II cuticular Hb4	0.190788345	37.28685902	0.044741802	0.87746061	18.7388236825	0.461101206	18.7388236825	0.461101206	40.6392857764506	0.000500	1	0.024606731661103	0.000487	-1	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0045095,keratin filament	GO:0005200,structural constituent of cytoskeleton;GO:0030280,structural constituent of skin epidermis	GO:0070268,cornification;GO:0001942,hair follicle development;GO:0031424,keratinization;GO:0035878,nail development;GO:0045616,regulation of keratinocyte differentiation	
NDUS2_HUMAN	O75306	NDUFS2	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	2.696410908	1.675043153	4.946856558	1.638390278	2.1857270305	3.292623418	2.1857270305	3.292623418	0.663825391798875	0.373789	0	1.50642023091364	0.374015	0	GO:0005759,mitochondrial matrix;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0051539,4 iron, 4 sulfur cluster binding;GO:0009055,electron transfer activity;GO:0046872,metal ion binding;GO:0051287,NAD binding;GO:0008137,NADH dehydrogenase (ubiquinone) activity;GO:0019826,oxygen sensor activity;GO:0048038,quinone binding;GO:0031625,ubiquitin protein ligase binding	GO:0071453,cellular response to oxygen levels;GO:0042063,gliogenesis;GO:0042775,mitochondrial ATP synthesis coupled electron transport;GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0061351,neural precursor cell proliferation;GO:0022008,neurogenesis;GO:0006979,response to oxidative stress	hsa:4720,path:hsa00190,Oxidative phosphorylation;hsa:4720,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4720,path:hsa04714,Thermogenesis;hsa:4720,path:hsa05010,Alzheimer disease;hsa:4720,path:hsa05012,Parkinson disease;hsa:4720,path:hsa05016,Huntington disease;hsa:4720,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
ITPR2_HUMAN	Q14571	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2	0.025534209	0.082054595	0.100065481	0.026199068	0.053794402	0.0631322745	0.053794402	0.0631322745	0.852090351979953	0.486862	0	1.17358446516424	0.486783	0	GO:0005938,cell cortex;GO:0030659,cytoplasmic vesicle membrane;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0031095,platelet dense tubular network membrane;GO:0043235,receptor complex;GO:0016529,sarcoplasmic reticulum;GO:0033017,sarcoplasmic reticulum membrane;GO:0030667,secretory granule membrane	GO:0005509,calcium ion binding;GO:0015085,calcium ion transmembrane transporter activity;GO:0070679,inositol 1,4,5 trisphosphate binding;GO:0005220,inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0044325,ion channel binding;GO:0035091,phosphatidylinositol binding;GO:0097110,scaffold protein binding	GO:0071320,cellular response to cAMP;GO:0071361,cellular response to ethanol;GO:0030168,platelet activation;GO:1903779,regulation of cardiac conduction;GO:0050796,regulation of insulin secretion;GO:0051209,release of sequestered calcium ion into cytosol;GO:0001666,response to hypoxia;GO:0007165,signal transduction	hsa:3709,path:hsa04371,Apelin signaling pathway;hsa:3709,path:hsa04020,Calcium signaling pathway;hsa:3709,path:hsa04070,Phosphatidylinositol signaling system;hsa:3709,path:hsa04022,cGMP-PKG signaling pathway;hsa:3709,path:hsa04114,Oocyte meiosis;hsa:3709,path:hsa04210,Apoptosis;hsa:3709,path:hsa04218,Cellular senescence;hsa:3709,path:hsa04540,Gap junction;hsa:3709,path:hsa04611,Platelet activation;hsa:3709,path:hsa04621,NOD-like receptor signaling pathway;hsa:3709,path:hsa04625,C-type lectin receptor signaling pathway;hsa:3709,path:hsa04922,Glucagon signaling pathway;hsa:3709,path:hsa04929,GnRH secretion;hsa:3709,path:hsa04912,GnRH signaling pathway;hsa:3709,path:hsa04915,Estrogen signaling pathway;hsa:3709,path:hsa04921,Oxytocin signaling pathway;hsa:3709,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:3709,path:hsa04918,Thyroid hormone synthesis;hsa:3709,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:3709,path:hsa04924,Renin secretion;hsa:3709,path:hsa04925,Aldosterone synthesis and secretion;hsa:3709,path:hsa04927,Cortisol synthesis and secretion;hsa:3709,path:hsa04270,Vascular smooth muscle contraction;hsa:3709,path:hsa04970,Salivary secretion;hsa:3709,path:hsa04971,Gastric acid secretion;hsa:3709,path:hsa04972,Pancreatic secretion;hsa:3709,path:hsa04724,Glutamatergic synapse;hsa:3709,path:hsa04725,Cholinergic synapse;hsa:3709,path:hsa04728,Dopaminergic synapse;hsa:3709,path:hsa04726,Serotonergic synapse;hsa:3709,path:hsa04720,Long-term potentiation;hsa:3709,path:hsa04730,Long-term depression;hsa:3709,path:hsa04723,Retrograde endocannabinoid signaling;hsa:3709,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:3709,path:hsa05205,Proteoglycans in cancer;hsa:3709,path:hsa05010,Alzheimer disease;hsa:3709,path:hsa05017,Spinocerebellar ataxia;hsa:3709,path:hsa04934,Cushing syndrome;hsa:3709,path:hsa05131,Shigellosis;hsa:3709,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3709,path:hsa05163,Human cytomegalovirus infection;hsa:3709,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection
GFPT2_HUMAN	O94808	GFPT2	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2	0.048621212	2.55E-05	0.03949493	0.156870208	0.024323356	0.098182569	0.024323356	0.098182569	0.247735990693012	0.033765	-1	4.03655519411055	0.033940	1	GO:0005829,cytosol	GO:0097367,carbohydrate derivative binding;GO:0004360,glutamine-fructose-6-phosphate transaminase (isomerizing) activity	GO:1990830,cellular response to leukemia inhibitory factor;GO:0006112,energy reserve metabolic process;GO:0006002,fructose 6-phosphate metabolic process;GO:0006541,glutamine metabolic process;GO:0006487,protein N-linked glycosylation;GO:0006048,UDP-N-acetylglucosamine biosynthetic process;GO:0006047,UDP-N-acetylglucosamine metabolic process	hsa:9945,path:hsa00520,Amino sugar and nucleotide sugar metabolism;hsa:9945,path:hsa00250,Alanine, aspartate and glutamate metabolism;hsa:9945,path:hsa04931,Insulin resistance
THIC_HUMAN	Q9BWD1	ACAT2	Acetyl-CoA acetyltransferase, cytosolic	1.356240313	0.991532115	1.380739802	2.556774413	1.173886214	1.9687571075	1.173886214	1.9687571075	0.596257511669707	0.313525	0	1.67712771818956	0.313803	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005739,mitochondrion	GO:0003985,acetyl-CoA C-acetyltransferase activity	GO:0006695,cholesterol biosynthetic process;GO:0006635,fatty acid beta-oxidation;GO:0006629,lipid metabolic process	hsa:39,path:hsa00620,Pyruvate metabolism;hsa:39,path:hsa00630,Glyoxylate and dicarboxylate metabolism;hsa:39,path:hsa00640,Propanoate metabolism;hsa:39,path:hsa00650,Butanoate metabolism;hsa:39,path:hsa00071,Fatty acid degradation;hsa:39,path:hsa00072,Synthesis and degradation of ketone bodies;hsa:39,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:39,path:hsa00310,Lysine degradation;hsa:39,path:hsa00380,Tryptophan metabolism;hsa:39,path:hsa00900,Terpenoid backbone biosynthesis;hsa:39,path:hsa04975,Fat digestion and absorption
CCDC6_HUMAN	Q16204	CCDC6	Coiled-coil domain-containing protein 6	0.159302095	0.276321403	0.357200934	2.55E-05	0.217811749	0.178613217	0.217811749	0.178613217	1.21946042212542	0.368782	0	0.820034813640838	0.368453	0	GO:0005856,cytoskeleton;GO:0005829,cytosol	GO:0042802,identical protein binding;GO:0017124,SH3 domain binding;GO:0005200,structural constituent of cytoskeleton		hsa:8030,path:hsa05200,Pathways in cancer;hsa:8030,path:hsa05216,Thyroid cancer
MCM7_HUMAN	P33993	MCM7	DNA replication licensing factor MCM7	0.940100137	0.333622306	1.082555718	0.325254507	0.6368612215	0.7039051125	0.6368612215	0.7039051125	0.904754362755108	0.466733	0	1.10527237133718	0.466609	0	GO:0000785,chromatin;GO:0000781,chromosome, telomeric region;GO:0071162,CMG complex;GO:0005829,cytosol;GO:0042555,MCM complex;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0003678,DNA helicase activity;GO:0003688,DNA replication origin binding;GO:0016787,hydrolase activity;GO:0003697,single-stranded DNA binding;GO:0003677,DNA binding	GO:0008283,cell population proliferation;GO:0006974,cellular response to DNA damage stimulus;GO:0071364,cellular response to epidermal growth factor stimulus;GO:0071466,cellular response to xenobiotic stimulus;GO:0006260,DNA replication;GO:0006270,DNA replication initiation;GO:0006271,DNA strand elongation involved in DNA replication;GO:0006268,DNA unwinding involved in DNA replication;GO:0000727,double-strand break repair via break-induced replication;GO:0036388,pre-replicative complex assembly;GO:0006267,pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0042325,regulation of phosphorylation;GO:0042493,response to drug;GO:0007049,cell cycle	hsa:4176,path:hsa03030,DNA replication;hsa:4176,path:hsa04110,Cell cycle
ATG9A_HUMAN	Q7Z3C6	ATG9A	Autophagy-related protein 9A	0.04617753	0.055370555	0.062059051	0.030234179	0.0507740425	0.046146615	0.0507740425	0.046146615	1.10027664000924	0.401915	0	0.908862338467535	0.401652	0	GO:0005776,autophagosome;GO:0005789,endoplasmic reticulum membrane;GO:0005768,endosome;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005770,late endosome;GO:0031902,late endosome membrane;GO:0016020,membrane;GO:0000407,phagophore assembly site;GO:0055037,recycling endosome;GO:0005802,trans-Golgi network;GO:0000421,autophagosome membrane;GO:0030659,cytoplasmic vesicle membrane;GO:0005794,Golgi apparatus;GO:0031410,cytoplasmic vesicle		GO:0000045,autophagosome assembly;GO:0000422,autophagy of mitochondrion;GO:0044805,late nucleophagy;GO:0034497,protein localization to phagophore assembly site;GO:0015031,protein transport;GO:0006914,autophagy	hsa:79065,path:hsa04140,Autophagy - animal;hsa:79065,path:hsa04136,Autophagy - other;hsa:79065,path:hsa04137,Mitophagy - animal
BRI3B_HUMAN	Q8WY22	BRI3BP	BRI3-binding protein	0.201622089	0.133735853	0.004042513	2.55E-05	0.167678971	0.0020340065	0.167678971	0.0020340065	82.4377753955064	0.000051	1	0.0121303612961699	0.000049	-1	GO:0016021,integral component of membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion			
PR38A_HUMAN	Q8NAV1	PRPF38A	Pre-mRNA-splicing factor 38A	0.915792805	1.004936504	1.276847179	1.032675105	0.9603646545	1.154761142	0.9603646545	1.154761142	0.83165653880307	0.495022	0	1.20241945243311	0.494961	0	GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0071011,precatalytic spliceosome;GO:0071005,U2-type precatalytic spliceosome	GO:0003723,RNA binding	GO:0000398,mRNA splicing, via spliceosome	hsa:84950,path:hsa03040,Spliceosome
RS30_HUMAN	P62861	FAU	40S ribosomal protein S30	0.064047812	0.030315496	0.038179114	0.074530176	0.047181654	0.056354645	0.047181654	0.056354645	0.837227419319206	0.492777	0	1.19441859753369	0.492711	0	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0005615,extracellular space;GO:0005654,nucleoplasm;GO:0015935,small ribosomal subunit;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0019731,antibacterial humoral response;GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0002181,cytoplasmic translation;GO:0050830,defense response to Gram-positive bacterium;GO:0002227,innate immune response in mucosa;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:2197,path:hsa03010,Ribosome
EXOC5_HUMAN	O00471	EXOC5	Exocyst complex component 5	0.194834035	0.271659025	0.248928194	0.481538186	0.23324653	0.36523319	0.23324653	0.36523319	0.638623587303224	0.351608	0	1.56586762512608	0.351855	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0000145,exocyst;GO:0030496,midbody	GO:0031267,small GTPase binding;GO:0047485,protein N-terminus binding	GO:0060271,cilium assembly;GO:0006887,exocytosis;GO:0006893,Golgi to plasma membrane transport;GO:0006892,post-Golgi vesicle-mediated transport;GO:0015031,protein transport;GO:1904019,epithelial cell apoptotic process;GO:0001736,establishment of planar polarity;GO:1905515,non-motile cilium assembly;GO:0072659,protein localization to plasma membrane	hsa:10640,path:hsa05132,Salmonella infection
FKBP2_HUMAN	P26885	FKBP2	Peptidyl-prolyl cis-trans isomerase FKBP2	2.900471998	5.270743418	1.097016743	0.673093572	4.085607708	0.8850551575	4.085607708	0.8850551575	4.61621817959973	0.072548	0	0.216627542523718	0.072083	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane	GO:0005528,FK506 binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity	GO:0061077,chaperone-mediated protein folding	
ARL8B_HUMAN	Q9NVJ2	ARL8B	ADP-ribosylation factor-like protein 8B	5.224587264	18.71447271	1.022996844	0.496680516	11.969529987	0.75983868	11.969529987	0.75983868	15.7527252850566	0.006358	1	0.0634810791088083	0.006257	-1	GO:1904115,axon cytoplasm;GO:0101004,cytolytic granule membrane;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0016020,membrane;GO:0030496,midbody;GO:0051233,spindle midzone;GO:0045202,synapse;GO:0005774,vacuolar membrane	GO:0043014,alpha-tubulin binding;GO:0048487,beta-tubulin binding;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0008089,anterograde axonal transport;GO:0002747,antigen processing and presentation following phagocytosis;GO:0002505,antigen processing and presentation of polysaccharide antigen via MHC class II;GO:0061909,autophagosome-lysosome fusion;GO:1990927,calcium ion regulated lysosome exocytosis;GO:0007049,cell cycle;GO:0051301,cell division;GO:0007059,chromosome segregation;GO:0016197,endosomal transport;GO:0090117,endosome to lysosome transport of low-density lipoprotein particle;GO:1902774,late endosome to lysosome transport;GO:0032418,lysosome localization;GO:0042267,natural killer cell mediated cytotoxicity;GO:0090385,phagosome-lysosome fusion;GO:0001778,plasma membrane repair;GO:0015031,protein transport;GO:0046754,viral exocytosis	
COMA1_HUMAN	Q8NFW1	COL22A1	Collagen alpha-1(XXII) chain	0.01562372	0.228147722	0.003247321	0.031861297	0.121885721	0.017554309	0.121885721	0.017554309	6.94335054715056	0.035841	1	0.144022686627911	0.035515	-1	GO:0005581,collagen trimer;GO:0005788,endoplasmic reticulum lumen;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0005201,extracellular matrix structural constituent	GO:0001525,angiogenesis;GO:0030199,collagen fibril organization;GO:0001886,endothelial cell morphogenesis;GO:0030198,extracellular matrix organization	hsa:169044,path:hsa04974,Protein digestion and absorption
RAB12_HUMAN	Q6IQ22	RAB12	Ras-related protein Rab-12	0.113727112	0.071643836	0.039691597	0.061537867	0.092685474	0.050614732	0.092685474	0.050614732	1.83119558945803	0.248964	0	0.546091310921062	0.248444	0	GO:0005776,autophagosome;GO:0005829,cytosol;GO:0005768,endosome;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0032593,insulin-responsive compartment;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0005886,plasma membrane;GO:0055037,recycling endosome;GO:0055038,recycling endosome membrane;GO:0008021,synaptic vesicle	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0006914,autophagy;GO:0044257,cellular protein catabolic process;GO:0032869,cellular response to insulin stimulus;GO:0008333,endosome to lysosome transport;GO:0072659,protein localization to plasma membrane;GO:0009306,protein secretion;GO:0032482,Rab protein signal transduction;GO:0017157,regulation of exocytosis;GO:0006904,vesicle docking involved in exocytosis	
EF1A1_HUMAN	P68104	EEF1A1	Elongation factor 1-alpha 1	237.3649551	463.7184514	242.2263636	141.0559232	350.54170325	191.6411434	350.54170325	191.6411434	1.82915681377635	0.249261	0	0.546699983548962	0.248742	0	GO:0030864,cortical actin cytoskeleton;GO:0005737,cytoplasm;GO:0098574,cytoplasmic side of lysosomal membrane;GO:0005829,cytosol;GO:0005853,eukaryotic translation elongation factor 1 complex;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0032587,ruffle membrane;GO:0034774,secretory granule lumen	GO:0005516,calmodulin binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0019900,kinase binding;GO:0019901,protein kinase binding;GO:0003723,RNA binding;GO:0003746,translation elongation factor activity;GO:0000049,tRNA binding	GO:0071364,cellular response to epidermal growth factor stimulus;GO:0043312,neutrophil degranulation;GO:1904714,regulation of chaperone-mediated autophagy;GO:1900022,regulation of D-erythro-sphingosine kinase activity;GO:0006412,translation;GO:0006414,translational elongation	hsa:1915,path:hsa03013,RNA transport;hsa:1915,path:hsa05134,Legionellosis;hsa:1915,path:hsa05140,Leishmaniasis
FLOT1_HUMAN	O75955	FLOT1	Flotillin-1	2.241963782	2.512694219	2.930851537	7.853371887	2.3773290005	5.392111712	2.3773290005	5.392111712	0.44089016093812	0.171764	0	2.26813861727423	0.172100	0	GO:0005912,adherens junction;GO:0016323,basolateral plasma membrane;GO:0005901,caveola;GO:0044291,cell-cell contact zone;GO:0005911,cell-cell junction;GO:0034451,centriolar satellite;GO:0031410,cytoplasmic vesicle;GO:0098691,dopaminergic synapse;GO:0005769,early endosome;GO:0005768,endosome;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0016600,flotillin complex;GO:0005925,focal adhesion;GO:0098982,GABA-ergic synapse;GO:0098978,glutamatergic synapse;GO:0030027,lamellipodium;GO:0005765,lysosomal membrane;GO:0042470,melanosome;GO:0016020,membrane;GO:0045121,membrane raft;GO:0005815,microtubule organizing center;GO:0005886,plasma membrane;GO:0048786,presynaptic active zone;GO:0042383,sarcolemma;GO:0001931,uropod	GO:0035255,ionotropic glutamate receptor binding;GO:0002020,protease binding	GO:0007409,axonogenesis;GO:0071360,cellular response to exogenous dsRNA;GO:0033227,dsRNA transport;GO:0022617,extracellular matrix disassembly;GO:0001765,membrane raft assembly;GO:0044854,plasma membrane raft assembly;GO:0060355,positive regulation of cell adhesion molecule production;GO:1901890,positive regulation of cell junction assembly;GO:2000049,positive regulation of cell-cell adhesion mediated by cadherin;GO:0001819,positive regulation of cytokine production;GO:0045807,positive regulation of endocytosis;GO:0034116,positive regulation of heterotypic cell-cell adhesion;GO:0032728,positive regulation of interferon-beta production;GO:1901741,positive regulation of myoblast fusion;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0032092,positive regulation of protein binding;GO:0001934,positive regulation of protein phosphorylation;GO:0048643,positive regulation of skeletal muscle tissue development;GO:0032226,positive regulation of synaptic transmission, dopaminergic;GO:0034141,positive regulation of toll-like receptor 3 signaling pathway;GO:0070528,protein kinase C signaling;GO:1903044,protein localization to membrane raft;GO:0072659,protein localization to plasma membrane;GO:0050821,protein stabilization;GO:0060544,regulation of necroptotic process;GO:0051580,regulation of neurotransmitter uptake;GO:0002090,regulation of receptor internalization;GO:0035023,regulation of Rho protein signal transduction;GO:0034976,response to endoplasmic reticulum stress	hsa:10211,path:hsa04910,Insulin signaling pathway
ACACA_HUMAN	Q13085	ACACA	Acetyl-CoA carboxylase 1	0.108880306	0.212436187	0.435147963	0.499517361	0.1606582465	0.467332662	0.1606582465	0.467332662	0.343777055539936	0.092182	0	2.90886196121903	0.092472	0	GO:0015629,actin cytoskeleton;GO:0005829,cytosol;GO:0001650,fibrillar center	GO:0003989,acetyl-CoA carboxylase activity;GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0046872,metal ion binding	GO:0006084,acetyl-CoA metabolic process;GO:0006853,carnitine shuttle;GO:0071380,cellular response to prostaglandin E stimulus;GO:0006633,fatty acid biosynthetic process;GO:0046949,fatty-acyl-CoA biosynthetic process;GO:0055088,lipid homeostasis;GO:2001295,malonyl-CoA biosynthetic process;GO:0031325,positive regulation of cellular metabolic process;GO:0051289,protein homotetramerization;GO:0019538,protein metabolic process;GO:0019216,regulation of lipid metabolic process;GO:0001894,tissue homeostasis	hsa:31,path:hsa00620,Pyruvate metabolism;hsa:31,path:hsa00640,Propanoate metabolism;hsa:31,path:hsa00061,Fatty acid biosynthesis;hsa:31,path:hsa04152,AMPK signaling pathway;hsa:31,path:hsa04910,Insulin signaling pathway;hsa:31,path:hsa04922,Glucagon signaling pathway
2AAA_HUMAN	P30153	PPP2R1A	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	9.93050049	9.03555534	11.46033093	14.18564504	9.483027915	12.822987985	9.483027915	12.822987985	0.739533400958731	0.437706	0	1.35220396902101	0.437867	0	GO:0000775,chromosome, centromeric region;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:0016328,lateral plasma membrane;GO:0016020,membrane;GO:0015630,microtubule cytoskeleton;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0000159,protein phosphatase type 2A complex;GO:0008287,protein serine/threonine phosphatase complex	GO:1990405,protein antigen binding;GO:0046982,protein heterodimerization activity;GO:0019888,protein phosphatase regulator activity	GO:0006915,apoptotic process;GO:0006672,ceramide metabolic process;GO:0007059,chromosome segregation;GO:0097711,ciliary basal body-plasma membrane docking;GO:0000086,G2/M transition of mitotic cell cycle;GO:0000188,inactivation of MAPK activity;GO:0007084,mitotic nuclear envelope reassembly;GO:0030308,negative regulation of cell growth;GO:0042532,negative regulation of tyrosine phosphorylation of STAT protein;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006470,protein dephosphorylation;GO:0065003,protein-containing complex assembly;GO:0030155,regulation of cell adhesion;GO:0045595,regulation of cell differentiation;GO:0006275,regulation of DNA replication;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0040008,regulation of growth;GO:0006355,regulation of transcription, DNA-templated;GO:0030111,regulation of Wnt signaling pathway;GO:0010033,response to organic substance;GO:0008380,RNA splicing;GO:0019932,second-messenger-mediated signaling	hsa:5518,path:hsa03015,mRNA surveillance pathway;hsa:5518,path:hsa04350,TGF-beta signaling pathway;hsa:5518,path:hsa04390,Hippo signaling pathway;hsa:5518,path:hsa04071,Sphingolipid signaling pathway;hsa:5518,path:hsa04151,PI3K-Akt signaling pathway;hsa:5518,path:hsa04152,AMPK signaling pathway;hsa:5518,path:hsa04114,Oocyte meiosis;hsa:5518,path:hsa04530,Tight junction;hsa:5518,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:5518,path:hsa04728,Dopaminergic synapse;hsa:5518,path:hsa04730,Long-term depression;hsa:5518,path:hsa05160,Hepatitis C;hsa:5518,path:hsa05165,Human papillomavirus infection;hsa:5518,path:hsa05142,Chagas disease (American trypanosomiasis)
RL18_HUMAN	Q07020	RPL18	60S ribosomal protein L18	6.264960698	12.84576952	2.933210788	0.590628208	9.555365109	1.761919498	9.555365109	1.761919498	5.42326997337083	0.055594	0	0.184390599197563	0.055182	0	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0005783,endoplasmic reticulum;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005634,nucleus;GO:0042788,polysomal ribosome;GO:0005791,rough endoplasmic reticulum;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6141,path:hsa03010,Ribosome
SEPT5_HUMAN	Q99719	SEPTIN5	Septin-5	0.060458005	0.086384479	0.101410942	0.260622101	0.073421242	0.1810165215	0.073421242	0.1810165215	0.405605197755388	0.141256	0	2.46545164000358	0.141584	0	GO:0032153,cell division site;GO:0015630,microtubule cytoskeleton;GO:0005886,plasma membrane;GO:0031105,septin complex;GO:0005940,septin ring;GO:0008021,synaptic vesicle;GO:0005856,cytoskeleton	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0060090,molecular adaptor activity;GO:0005198,structural molecule activity	GO:0030534,adult behavior;GO:0034613,cellular protein localization;GO:0061640,cytoskeleton-dependent cytokinesis;GO:0017157,regulation of exocytosis;GO:2000300,regulation of synaptic vesicle exocytosis;GO:0035176,social behavior;GO:0016080,synaptic vesicle targeting	hsa:5413,path:hsa05012,Parkinson disease
CDC42_HUMAN	P60953	CDC42	Cell division control protein 42 homolog	4.857634195	3.971276521	0.670958001	0.11833439	4.414455358	0.3946461955	4.414455358	0.3946461955	11.1858556051885	0.013795	1	0.0893986151167688	0.013618	-1	GO:0045177,apical part of cell;GO:0005911,cell-cell junction;GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0030175,filopodium;GO:0005925,focal adhesion;GO:0000139,Golgi membrane;GO:0017119,Golgi transport complex;GO:0031256,leading edge membrane;GO:0016020,membrane;GO:0005815,microtubule organizing center;GO:0030496,midbody;GO:0072686,mitotic spindle;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0045335,phagocytic vesicle;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0098685,Schaffer collateral - CA1 synapse;GO:0030141,secretory granule;GO:0051233,spindle midzone;GO:0000322,storage vacuole	GO:0034191,apolipoprotein A-I receptor binding;GO:0003925,G protein activity;GO:0032427,GBD domain binding;GO:0005525,GTP binding;GO:0030742,GTP-dependent protein binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0031435,mitogen-activated protein kinase kinase kinase binding;GO:0019901,protein kinase binding;GO:0031996,thioesterase binding;GO:0061630,ubiquitin protein ligase activity	GO:0030036,actin cytoskeleton organization;GO:0090135,actin filament branching;GO:0007015,actin filament organization;GO:0034332,adherens junction organization;GO:0007596,blood coagulation;GO:0003161,cardiac conduction system development;GO:0032488,Cdc42 protein signal transduction;GO:0034329,cell junction assembly;GO:0016477,cell migration;GO:0030031,cell projection assembly;GO:0034613,cellular protein localization;GO:0071346,cellular response to interferon-gamma;GO:0036336,dendritic cell migration;GO:0060997,dendritic spine morphogenesis;GO:0006897,endocytosis;GO:0048013,ephrin receptor signaling pathway;GO:0045198,establishment of epithelial cell apical/basal polarity;GO:0051683,establishment of Golgi localization;GO:0007163,establishment or maintenance of cell polarity;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0046847,filopodium assembly;GO:0007030,Golgi organization;GO:0060047,heart contraction;GO:0007229,integrin-mediated signaling pathway;GO:0035722,interleukin-12-mediated signaling pathway;GO:0030225,macrophage differentiation;GO:0099563,modification of synaptic structure;GO:0042059,negative regulation of epidermal growth factor receptor signaling pathway;GO:0031333,negative regulation of protein-containing complex assembly;GO:0048664,neuron fate determination;GO:0038189,neuropilin signaling pathway;GO:0007097,nuclear migration;GO:0072384,organelle transport along microtubule;GO:0006911,phagocytosis, engulfment;GO:2000251,positive regulation of actin cytoskeleton reorganization;GO:0030307,positive regulation of cell growth;GO:0032467,positive regulation of cytokinesis;GO:0045740,positive regulation of DNA replication;GO:0060501,positive regulation of epithelial cell proliferation involved in lung morphogenesis;GO:0051491,positive regulation of filopodium assembly;GO:0090316,positive regulation of intracellular protein transport;GO:0046330,positive regulation of JNK cascade;GO:0010592,positive regulation of lamellipodium assembly;GO:0051149,positive regulation of muscle cell differentiation;GO:0043525,positive regulation of neuron apoptotic process;GO:0043552,positive regulation of phosphatidylinositol 3-kinase activity;GO:0048549,positive regulation of pinocytosis;GO:0031274,positive regulation of pseudopodium assembly;GO:0051496,positive regulation of stress fiber assembly;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0051835,positive regulation of synapse structural plasticity;GO:0051988,regulation of attachment of spindle microtubules to kinetochore;GO:0051489,regulation of filopodium assembly;GO:0010591,regulation of lamellipodium assembly;GO:0007088,regulation of mitotic nuclear division;GO:0099159,regulation of modification of postsynaptic structure;GO:0043393,regulation of protein binding;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0051492,regulation of stress fiber assembly;GO:0002040,sprouting angiogenesis;GO:0060661,submandibular salivary gland formation;GO:0021762,substantia nigra development;GO:0031295,T cell costimulation;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:0039694,viral RNA genome replication;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0007264,small GTPase mediated signal transduction	hsa:998,path:hsa04014,Ras signaling pathway;hsa:998,path:hsa04015,Rap1 signaling pathway;hsa:998,path:hsa04010,MAPK signaling pathway;hsa:998,path:hsa04370,VEGF signaling pathway;hsa:998,path:hsa04144,Endocytosis;hsa:998,path:hsa04510,Focal adhesion;hsa:998,path:hsa04520,Adherens junction;hsa:998,path:hsa04530,Tight junction;hsa:998,path:hsa04810,Regulation of actin cytoskeleton;hsa:998,path:hsa04660,T cell receptor signaling pathway;hsa:998,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:998,path:hsa04670,Leukocyte transendothelial migration;hsa:998,path:hsa04062,Chemokine signaling pathway;hsa:998,path:hsa04912,GnRH signaling pathway;hsa:998,path:hsa04722,Neurotrophin signaling pathway;hsa:998,path:hsa04360,Axon guidance;hsa:998,path:hsa05200,Pathways in cancer;hsa:998,path:hsa05205,Proteoglycans in cancer;hsa:998,path:hsa05203,Viral carcinogenesis;hsa:998,path:hsa05212,Pancreatic cancer;hsa:998,path:hsa05211,Renal cell carcinoma;hsa:998,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:998,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:998,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:998,path:hsa05130,Pathogenic Escherichia coli infection;hsa:998,path:hsa05132,Salmonella infection;hsa:998,path:hsa05131,Shigellosis;hsa:998,path:hsa05135,Yersinia infection;hsa:998,path:hsa05100,Bacterial invasion of epithelial cells;hsa:998,path:hsa05165,Human papillomavirus infection
MCM6_HUMAN	Q14566	MCM6	DNA replication licensing factor MCM6	0.915687636	0.338387534	0.835320834	0.347148809	0.627037585	0.5912348215	0.627037585	0.5912348215	1.06055591145523	0.413947	0	0.942901726536855	0.413709	0	GO:0000781,chromosome, telomeric region;GO:0071162,CMG complex;GO:0042555,MCM complex;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0003678,DNA helicase activity;GO:0003688,DNA replication origin binding;GO:0016787,hydrolase activity;GO:0042802,identical protein binding;GO:0003697,single-stranded DNA binding	GO:0006260,DNA replication;GO:0006270,DNA replication initiation;GO:0006268,DNA unwinding involved in DNA replication;GO:0000727,double-strand break repair via break-induced replication;GO:1902969,mitotic DNA replication;GO:0036388,pre-replicative complex assembly;GO:0006267,pre-replicative complex assembly involved in nuclear cell cycle DNA replication	hsa:4175,path:hsa03030,DNA replication;hsa:4175,path:hsa04110,Cell cycle
HNRPQ_HUMAN	O60506	SYNCRIP	Heterogeneous nuclear ribonucleoprotein Q	8.295901945	10.89759833	11.30844331	6.789268398	9.5967501375	9.048855854	9.5967501375	9.048855854	1.06054845964397	0.413949	0	0.94290835171804	0.413711	0	GO:0071013,catalytic step 2 spliceosome;GO:0070937,CRD-mediated mRNA stability complex;GO:0005783,endoplasmic reticulum;GO:0097452,GAIT complex;GO:0071204,histone pre-mRNA 3'end processing complex;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex	GO:0048027,mRNA 5'-UTR binding;GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0071346,cellular response to interferon-gamma;GO:0070934,CRD-mediated mRNA stabilization;GO:0000398,mRNA splicing, via spliceosome;GO:0017148,negative regulation of translation;GO:0001649,osteoblast differentiation;GO:0006396,RNA processing;GO:0008380,RNA splicing;GO:0016032,viral process	
THUM1_HUMAN	Q9NXG2	THUMPD1	THUMP domain-containing protein 1	0.433832941	0.046454898	0.621643034	0.269716369	0.2401439195	0.4456797015	0.2401439195	0.4456797015	0.538826243806394	0.260872	0	1.8558858472367	0.261185	0	GO:0005654,nucleoplasm	GO:0003723,RNA binding	GO:0000154,rRNA modification;GO:0006400,tRNA modification	
AATC_HUMAN	P17174	GOT1	Aspartate aminotransferase, cytoplasmic	3.991413078	1.989540899	4.17561203	3.138213999	2.9904769885	3.6569130145	2.9904769885	3.6569130145	0.817759945791021	0.498753	0	1.22285275177265	0.498845	0	GO:0043679,axon terminus;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005764,lysosome;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0031406,carboxylic acid binding;GO:0004069,L-aspartate;GO:0047801,L-cysteine;GO:0004609,phosphatidylserine decarboxylase activity;GO:0030170,pyridoxal phosphate binding	GO:0006103,2-oxoglutarate metabolic process;GO:0006532,aspartate biosynthetic process;GO:0006533,aspartate catabolic process;GO:0009066,aspartate family amino acid metabolic process;GO:0006531,aspartate metabolic process;GO:0032869,cellular response to insulin stimulus;GO:0071260,cellular response to mechanical stimulus;GO:0055089,fatty acid homeostasis;GO:0006094,gluconeogenesis;GO:0019551,glutamate catabolic process to 2-oxoglutarate;GO:0019550,glutamate catabolic process to aspartate;GO:0006536,glutamate metabolic process;GO:0006114,glycerol biosynthetic process;GO:0032966,negative regulation of collagen biosynthetic process;GO:0051481,negative regulation of cytosolic calcium ion concentration;GO:0051902,negative regulation of mitochondrial depolarization;GO:0007219,Notch signaling pathway;GO:0006107,oxaloacetate metabolic process;GO:0030511,positive regulation of transforming growth factor beta receptor signaling pathway;GO:0046686,response to cadmium ion;GO:0009743,response to carbohydrate;GO:0051384,response to glucocorticoid;GO:0035902,response to immobilization stress;GO:1990267,response to transition metal nanoparticle;GO:0060290,transdifferentiation	hsa:2805,path:hsa00250,Alanine, aspartate and glutamate metabolism;hsa:2805,path:hsa00270,Cysteine and methionine metabolism;hsa:2805,path:hsa00220,Arginine biosynthesis;hsa:2805,path:hsa00330,Arginine and proline metabolism;hsa:2805,path:hsa00350,Tyrosine metabolism;hsa:2805,path:hsa00360,Phenylalanine metabolism;hsa:2805,path:hsa00400,Phenylalanine, tyrosine and tryptophan biosynthesis
IST1_HUMAN	P53990	IST1	IST1 homolog	2.065447557	1.560312621	2.204204768	3.090723426	1.812880089	2.647464097	1.812880089	2.647464097	0.684760972227832	0.391895	0	1.46036360212901	0.392104	0	GO:0035578,azurophil granule lumen;GO:0005813,centrosome;GO:0005829,cytosol;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0090543,Flemming body;GO:0043231,intracellular membrane-bounded organelle;GO:0030496,midbody;GO:0005635,nuclear envelope	GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0090541,MIT domain binding;GO:0019904,protein domain specific binding;GO:0044877,protein-containing complex binding	GO:0009838,abscission;GO:0051301,cell division;GO:0061640,cytoskeleton-dependent cytokinesis;GO:1904903,ESCRT III complex disassembly;GO:0045184,establishment of protein localization;GO:0007084,mitotic nuclear envelope reassembly;GO:0036258,multivesicular body assembly;GO:0043312,neutrophil degranulation;GO:0048672,positive regulation of collateral sprouting;GO:0045862,positive regulation of proteolysis;GO:0008104,protein localization;GO:0015031,protein transport;GO:0046745,viral capsid secondary envelopment;GO:0019076,viral release from host cell;GO:0007049,cell cycle	hsa:9798,path:hsa04144,Endocytosis
ARL8A_HUMAN	Q96BM9	ARL8A	ADP-ribosylation factor-like protein 8A	0.171883808	0.498346182	0.036209594	0.091940521	0.335114995	0.0640750575	0.335114995	0.0640750575	5.23003814705902	0.059109	0	0.191203194294544	0.058685	0	GO:1904115,axon cytoplasm;GO:0035577,azurophil granule membrane;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0101003,ficolin-1-rich granule membrane;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0030496,midbody;GO:0005886,plasma membrane;GO:0051233,spindle midzone;GO:0045202,synapse;GO:0005774,vacuolar membrane;GO:0030424,axon;GO:0005819,spindle	GO:0043014,alpha-tubulin binding;GO:0048487,beta-tubulin binding;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0008089,anterograde axonal transport;GO:0007049,cell cycle;GO:0051301,cell division;GO:0007059,chromosome segregation;GO:0043312,neutrophil degranulation;GO:0015031,protein transport	
PURA2_HUMAN	P30520	ADSS2	Adenylosuccinate synthetase isozyme 2	0.936790343	0.712778768	1.379167863	0.608812326	0.8247845555	0.9939900945	0.8247845555	0.9939900945	0.829771403219954	0.495785	0	1.20515119720861	0.495725	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005739,mitochondrion	GO:0004019,adenylosuccinate synthase activity;GO:0005525,GTP binding;GO:0000287,magnesium ion binding;GO:0042301,phosphate ion binding	GO:0044208,'de novo' AMP biosynthetic process;GO:0006167,AMP biosynthetic process;GO:0006531,aspartate metabolic process;GO:0071257,cellular response to electrical stimulus;GO:0002376,immune system process;GO:0046040,IMP metabolic process;GO:0009168,purine ribonucleoside monophosphate biosynthetic process;GO:0060359,response to ammonium ion;GO:0014074,response to purine-containing compound	hsa:159,path:hsa00230,Purine metabolism;hsa:159,path:hsa00250,Alanine, aspartate and glutamate metabolism
SATT_HUMAN	P43007	SLC1A4	Neutral amino acid transporter A	1.495844767	1.807783948	0.859068054	3.211113548	1.6518143575	2.035090801	1.6518143575	2.035090801	0.811666170712547	0.494193	0	1.23203360702112	0.494290	0	GO:0009986,cell surface;GO:0005813,centrosome;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0005882,intermediate filament;GO:0042470,melanosome;GO:0016020,membrane;GO:0043025,neuronal cell body;GO:0005886,plasma membrane;GO:0045202,synapse	GO:0005254,chloride channel activity;GO:0015180,L-alanine transmembrane transporter activity;GO:0015183,L-aspartate transmembrane transporter activity;GO:0015184,L-cystine transmembrane transporter activity;GO:0015186,L-glutamine transmembrane transporter activity;GO:0034590,L-hydroxyproline transmembrane transporter activity;GO:0015193,L-proline transmembrane transporter activity;GO:0015194,L-serine transmembrane transporter activity;GO:0015195,L-threonine transmembrane transporter activity;GO:0015293,symporter activity	GO:0006865,amino acid transport;GO:0050890,cognition;GO:0006868,glutamine transport;GO:0034589,hydroxyproline transport;GO:1904273,L-alanine import across plasma membrane;GO:0015808,L-alanine transport;GO:0140009,L-aspartate import across plasma membrane;GO:0015811,L-cystine transport;GO:1903812,L-serine import across plasma membrane;GO:0015825,L-serine transport;GO:0015824,proline transport;GO:0035249,synaptic transmission, glutamatergic;GO:0015826,threonine transport;GO:0150104,transport across blood-brain barrier	
COPZ1_HUMAN	P61923	COPZ1	Coatomer subunit zeta-1	1.522580336	2.892518357	0.220724155	0.128189768	2.2075493465	0.1744569615	2.2075493465	0.1744569615	12.6538335158382	0.010527	1	0.0790274345516199	0.010381	-1	GO:0030126,COPI vesicle coat;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0000139,Golgi membrane;GO:0030133,transport vesicle		GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006891,intra-Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0015031,protein transport;GO:1901998,toxin transport	
COPB_HUMAN	P53618	COPB1	Coatomer subunit beta	8.669510975	7.017760264	14.11943228	8.067549883	7.8436356195	11.0934910815	7.8436356195	11.0934910815	0.707048445063466	0.410820	0	1.41433024424548	0.411010	0	GO:0030126,COPI vesicle coat;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0101003,ficolin-1-rich granule membrane;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005798,Golgi-associated vesicle;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0070821,tertiary granule membrane;GO:0030133,transport vesicle;GO:0030117,membrane coat	GO:0005198,structural molecule activity	GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006891,intra-Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0043312,neutrophil degranulation;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0016032,viral process;GO:0016192,vesicle-mediated transport	
CHD3_HUMAN	Q12873	CHD3	Chromodomain-helicase-DNA-binding protein 3	0.399448512	0.198629461	0.308359302	0.284162561	0.2990389865	0.2962609315	0.2990389865	0.2962609315	1.00937705483452	0.430259	0	0.990710057466035	0.430055	0	GO:0034451,centriolar satellite;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016581,NuRD complex;GO:0016605,PML body	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0003677,DNA binding;GO:0003678,DNA helicase activity;GO:0036121,double-stranded DNA helicase activity;GO:0004386,helicase activity;GO:0070615,nucleosome-dependent ATPase activity;GO:0003723,RNA binding;GO:0000976,transcription regulatory region sequence-specific DNA binding;GO:0008270,zinc ion binding;GO:0016787,hydrolase activity;GO:0046872,metal ion binding	GO:0043044,ATP-dependent chromatin remodeling;GO:0007098,centrosome cycle;GO:0006333,chromatin assembly or disassembly;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0006357,regulation of transcription by RNA polymerase II;GO:0006355,regulation of transcription, DNA-templated;GO:0007051,spindle organization;GO:0006325,chromatin organization	
NCK2_HUMAN	O43639	NCK2	Cytoplasmic protein NCK2	0.070578932	0.028948277	0.083264672	0.176550198	0.0497636045	0.129907435	0.0497636045	0.129907435	0.383069718065021	0.122607	0	2.61049086586965	0.122925	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0014069,postsynaptic density;GO:0012506,vesicle membrane	GO:0008093,cytoskeletal anchor activity;GO:0001784,phosphotyrosine residue binding;GO:0044877,protein-containing complex binding;GO:0097110,scaffold protein binding;GO:0035591,signaling adaptor activity;GO:0030159,signaling receptor complex adaptor activity;GO:0003779,actin binding	GO:0007015,actin filament organization;GO:0016477,cell migration;GO:0060996,dendritic spine development;GO:0048013,ephrin receptor signaling pathway;GO:0007173,epidermal growth factor receptor signaling pathway;GO:0001771,immunological synapse formation;GO:0030032,lamellipodium assembly;GO:0008285,negative regulation of cell population proliferation;GO:1903912,negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;GO:0033137,negative regulation of peptidyl-serine phosphorylation;GO:1903898,negative regulation of PERK-mediated unfolded protein response;GO:1990441,negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:0030838,positive regulation of actin filament polymerization;GO:1902237,positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0042102,positive regulation of T cell proliferation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0036493,positive regulation of translation in response to endoplasmic reticulum stress;GO:0007176,regulation of epidermal growth factor-activated receptor activity;GO:0007172,signal complex assembly;GO:0007165,signal transduction;GO:0042110,T cell activation;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:0051017,actin filament bundle assembly;GO:0051016,barbed-end actin filament capping	hsa:8440,path:hsa04012,ErbB signaling pathway;hsa:8440,path:hsa04660,T cell receptor signaling pathway;hsa:8440,path:hsa04360,Axon guidance;hsa:8440,path:hsa05130,Pathogenic Escherichia coli infection
PI15_HUMAN	O43692	PI15	Peptidase inhibitor 15	0.364897231	0.119038554	2.55E-05	2.55E-05	0.2419678925	2.55e-005	0.2419678925	2.55e-005	9488.93696078431	0.000000	1	0.00010538588296379	0.000000	-1	GO:0070062,extracellular exosome;GO:0005615,extracellular space	GO:0030414,peptidase inhibitor activity	GO:0007275,multicellular organism development;GO:0010466,negative regulation of peptidase activity	
PEBP1_HUMAN	P30086	PEBP1	Phosphatidylethanolamine-binding protein 1	14.95283454	68.77733184	2.993944961	1.279409141	41.86508319	2.136677051	41.86508319	2.136677051	19.5935474527638	0.003730	1	0.0510372102045738	0.003663	-1	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0019899,enzyme binding;GO:0008429,phosphatidylethanolamine binding;GO:0019901,protein kinase binding;GO:0003723,RNA binding;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0000165,MAPK cascade;GO:0043409,negative regulation of MAPK cascade	
HV551_HUMAN	A0A0C4DH38	IGHV5-51	Immunoglobulin heavy variable 5-51	0.375264097	0.023803837	0.683740057	0.770417706	0.199533967	0.7270788815	0.199533967	0.7270788815	0.274432351257888	0.047289	-1	3.64388526140013	0.047501	1	GO:0009897,external side of plasma membrane;GO:0042571,immunoglobulin complex, circulating	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation	
KRT34_HUMAN	O76011	KRT34	Keratin, type I cuticular Ha4	2.55E-05	0.126699686	2.55E-05	0.131954463	0.063362593	0.0659899815	0.063362593	0.0659899815	0.960185039603322	0.446858	0	1.04146592454005	0.446690	0	GO:0005829,cytosol;GO:0005615,extracellular space;GO:0005882,intermediate filament	GO:0005198,structural molecule activity	GO:0070268,cornification;GO:0008544,epidermis development;GO:0031424,keratinization	hsa:100653049,path:hsa04915,Estrogen signaling pathway;hsa:100653049,path:hsa05150,Staphylococcus aureus infection
NH2L1_HUMAN	P55769	SNU13	NHP2-like protein 1	0.632442976	1.065546337	0.329971369	0.291790166	0.8489946565	0.3108807675	0.8489946565	0.3108807675	2.7309333521251	0.155142	0	0.366175175685573	0.154573	0	GO:0031428,box C/D RNP complex;GO:0001651,dense fibrillar component;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0071011,precatalytic spliceosome;GO:0032991,protein-containing complex;GO:0032040,small-subunit processome;GO:0071005,U2-type precatalytic spliceosome;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005690,U4atac snRNP;GO:1990904,ribonucleoprotein complex	GO:0051117,ATPase binding;GO:0034512,box C/D RNA binding;GO:0003723,RNA binding;GO:0034511,U3 snoRNA binding;GO:0030621,U4 snRNA binding;GO:0030622,U4atac snRNA binding	GO:0000470,maturation of LSU-rRNA;GO:0030490,maturation of SSU-rRNA;GO:0000398,mRNA splicing, via spliceosome;GO:0006364,rRNA processing;GO:0042254,ribosome biogenesis;GO:0008380,RNA splicing	hsa:4809,path:hsa03040,Spliceosome;hsa:4809,path:hsa03008,Ribosome biogenesis in eukaryotes
PA1B3_HUMAN	Q15102	PAFAH1B3	Platelet-activating factor acetylhydrolase IB subunit alpha1	16.96019475	21.1793348	3.566516607	1.786576435	19.069764775	2.676546521	19.069764775	2.676546521	7.12476492576532	0.034161	1	0.140355507924717	0.033845	-1	GO:0008247,1-alkyl-2-acetylglycerophosphocholine esterase complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane	GO:0003847,1-alkyl-2-acetylglycerophosphocholine esterase activity;GO:0042802,identical protein binding;GO:0047179,platelet-activating factor acetyltransferase activity;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0044877,protein-containing complex binding	GO:0007420,brain development;GO:0016042,lipid catabolic process;GO:0006629,lipid metabolic process;GO:0007399,nervous system development;GO:0007283,spermatogenesis	hsa:5050,path:hsa00565,Ether lipid metabolism
RIPK1_HUMAN	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	0.119386951	0.125528459	0.215223683	0.151568791	0.122457705	0.183396237	0.122457705	0.183396237	0.667722015474069	0.377182	0	1.49762921818598	0.377405	0	GO:0005829,cytosol;GO:0031264,death-inducing signaling complex;GO:0010008,endosome membrane;GO:0045121,membrane raft;GO:0005739,mitochondrion;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0043235,receptor complex;GO:0097342,ripoptosome	GO:0005524,ATP binding;GO:0070513,death domain binding;GO:0005123,death receptor binding;GO:0042802,identical protein binding;GO:0004706,JUN kinase kinase kinase activity;GO:0042803,protein homodimerization activity;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0044877,protein-containing complex binding;GO:0031625,ubiquitin protein ligase binding	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007257,activation of JUN kinase activity;GO:1990000,amyloid fibril formation;GO:0006915,apoptotic process;GO:0097190,apoptotic signaling pathway;GO:0008219,cell death;GO:0044257,cellular protein catabolic process;GO:0070301,cellular response to hydrogen peroxide;GO:0071356,cellular response to tumor necrosis factor;GO:0071550,death-inducing signaling complex assembly;GO:0097191,extrinsic apoptotic signaling pathway;GO:0007249,I-kappaB kinase/NF-kappaB signaling;GO:0006954,inflammatory response;GO:0019054,modulation by virus of host cellular process;GO:0002756,MyD88-independent toll-like receptor signaling pathway;GO:0070266,necroptotic process;GO:0097527,necroptotic signaling pathway;GO:0043066,negative regulation of apoptotic process;GO:2001237,negative regulation of extrinsic apoptotic signaling pathway;GO:1902042,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0043124,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0060546,negative regulation of necroptotic process;GO:0062099,negative regulation of programmed necrotic cell death;GO:0036289,peptidyl-serine autophosphorylation;GO:0043065,positive regulation of apoptotic process;GO:2001238,positive regulation of extrinsic apoptotic signaling pathway;GO:1905206,positive regulation of hydrogen peroxide-induced cell death;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0050729,positive regulation of inflammatory response;GO:0070105,positive regulation of interleukin-6-mediated signaling pathway;GO:0032757,positive regulation of interleukin-8 production;GO:0046330,positive regulation of JNK cascade;GO:0045651,positive regulation of macrophage differentiation;GO:0060545,positive regulation of necroptotic process;GO:0010940,positive regulation of necrotic cell death;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:1903800,positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:0043068,positive regulation of programmed cell death;GO:0001934,positive regulation of protein phosphorylation;GO:2000379,positive regulation of reactive oxygen species metabolic process;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0032760,positive regulation of tumor necrosis factor production;GO:0097300,programmed necrotic cell death;GO:0046777,protein autophosphorylation;GO:0016579,protein deubiquitination;GO:0070926,regulation of ATP;GO:1902041,regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0060544,regulation of necroptotic process;GO:0010803,regulation of tumor necrosis factor-mediated signaling pathway;GO:0034612,response to tumor necrosis factor;GO:0097343,ripoptosome assembly;GO:0070231,T cell apoptotic process;GO:0034138,toll-like receptor 3 signaling pathway;GO:0035666,TRIF-dependent toll-like receptor signaling pathway;GO:0033209,tumor necrosis factor-mediated signaling pathway	hsa:8737,path:hsa04064,NF-kappa B signaling pathway;hsa:8737,path:hsa04668,TNF signaling pathway;hsa:8737,path:hsa04210,Apoptosis;hsa:8737,path:hsa04217,Necroptosis;hsa:8737,path:hsa04620,Toll-like receptor signaling pathway;hsa:8737,path:hsa04621,NOD-like receptor signaling pathway;hsa:8737,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:8737,path:hsa04623,Cytosolic DNA-sensing pathway;hsa:8737,path:hsa05130,Pathogenic Escherichia coli infection;hsa:8737,path:hsa05132,Salmonella infection;hsa:8737,path:hsa05131,Shigellosis;hsa:8737,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:8737,path:hsa05160,Hepatitis C;hsa:8737,path:hsa05163,Human cytomegalovirus infection;hsa:8737,path:hsa05169,Epstein-Barr virus infection
LRRF1_HUMAN	Q32MZ4	LRRFIP1	Leucine-rich repeat flightless-interacting protein 1	0.210143344	0.386907193	0.815865807	0.48864759	0.2985252685	0.6522566985	0.2985252685	0.6522566985	0.457680648104528	0.186707	0	2.18492961007085	0.187042	0	GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0045296,cadherin binding;GO:0003677,DNA binding;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227,DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003725,double-stranded RNA binding;GO:0042803,protein homodimerization activity;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0032481,positive regulation of type I interferon production;GO:0006357,regulation of transcription by RNA polymerase II;GO:0006355,regulation of transcription, DNA-templated	
RBGPR_HUMAN	Q9H2M9	RAB3GAP2	Rab3 GTPase-activating protein non-catalytic subunit	1.825477883	1.479175132	1.885529508	1.437430093	1.6523265075	1.6614798005	1.6523265075	1.6614798005	0.994490879156493	0.435184	0	1.00553963938632	0.434991	0	GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0005886,plasma membrane;GO:0032991,protein-containing complex	GO:0008047,enzyme activator activity;GO:0030234,enzyme regulator activity;GO:0005096,GTPase activator activity;GO:0031267,small GTPase binding	GO:0097051,establishment of protein localization to endoplasmic reticulum membrane;GO:0006886,intracellular protein transport;GO:2000786,positive regulation of autophagosome assembly;GO:1903373,positive regulation of endoplasmic reticulum tubular network organization;GO:1903061,positive regulation of protein lipidation;GO:0043087,regulation of GTPase activity	
TCP4_HUMAN	P53999	SUB1	Activated RNA polymerase II transcriptional coactivator p15	5.238407071	5.334595887	1.144435382	0.348913219	5.286501479	0.7466743005	5.286501479	0.7466743005	7.08006352362733	0.034565	1	0.141241670595587	0.034246	-1	GO:0070062,extracellular exosome;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005667,transcription regulator complex	GO:0042802,identical protein binding;GO:0003723,RNA binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003697,single-stranded DNA binding;GO:0003713,transcription coactivator activity	GO:0051053,negative regulation of DNA metabolic process;GO:0060261,positive regulation of transcription initiation from RNA polymerase II promoter;GO:0006357,regulation of transcription by RNA polymerase II;GO:0060395,SMAD protein signal transduction	
TRI22_HUMAN	Q8IYM9	TRIM22	E3 ubiquitin-protein ligase TRIM22	0.056517225	0.074181645	0.079188851	0.032828802	0.065349435	0.0560088265	0.065349435	0.0560088265	1.16677029467846	0.382908	0	0.85706672903905	0.382607	0	GO:0015030,Cajal body;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0016604,nuclear body;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:0019901,protein kinase binding;GO:0030674,protein-macromolecule adaptor activity;GO:0003713,transcription coactivator activity;GO:0003714,transcription corepressor activity;GO:0061630,ubiquitin protein ligase activity;GO:0008270,zinc ion binding	GO:0051607,defense response to virus;GO:0006955,immune response;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0010508,positive regulation of autophagy;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0000209,protein polyubiquitination;GO:0016567,protein ubiquitination;GO:0010468,regulation of gene expression;GO:0032880,regulation of protein localization;GO:0006355,regulation of transcription, DNA-templated;GO:0046596,regulation of viral entry into host cell;GO:0009615,response to virus;GO:0016032,viral process	
DDX1_HUMAN	Q92499	DDX1	ATP-dependent RNA helicase DDX1	4.83488844	4.949954527	7.089767874	14.15455496	4.8924214835	10.622161417	4.8924214835	10.622161417	0.46058624901614	0.189314	0	2.17114601692105	0.189650	0	GO:0071920,cleavage body;GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0072669,tRNA-splicing ligase complex	GO:0005524,ATP binding;GO:0003682,chromatin binding;GO:0003677,DNA binding;GO:0033677,DNA/RNA helicase activity;GO:0004527,exonuclease activity;GO:0004386,helicase activity;GO:0004518,nuclease activity;GO:0008143,poly(A) binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0003712,transcription coregulator activity;GO:0003725,double-stranded RNA binding;GO:0003676,nucleic acid binding	GO:0051607,defense response to virus;GO:0032508,DNA duplex unwinding;GO:0006302,double-strand break repair;GO:0045087,innate immune response;GO:0007275,multicellular organism development;GO:0090305,nucleic acid phosphodiester bond hydrolysis;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:1903608,protein localization to cytoplasmic stress granule;GO:0006446,regulation of translational initiation;GO:0000245,spliceosomal complex assembly;GO:0006388,tRNA splicing, via endonucleolytic cleavage and ligation;GO:0016032,viral process;GO:0002735,positive regulation of myeloid dendritic cell cytokine production;GO:0043330,response to exogenous dsRNA;GO:0009615,response to virus;GO:0006397,mRNA processing;GO:0008033,tRNA processing	
AP4A_HUMAN	P50583	NUDT2	Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]	0.149927723	1.493389977	0.087464168	0.006952803	0.82165885	0.0472084855	0.82165885	0.0472084855	17.4048974733578	0.005002	1	0.0574550928283679	0.004918	-1	GO:0005759,mitochondrial matrix	GO:0004081,bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity;GO:0008803,bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity;GO:0005525,GTP binding	GO:0006167,AMP biosynthetic process;GO:0006915,apoptotic process;GO:0006754,ATP biosynthetic process;GO:0034599,cellular response to oxidative stress;GO:0006139,nucleobase-containing compound metabolic process	hsa:318,path:hsa00230,Purine metabolism;hsa:318,path:hsa00240,Pyrimidine metabolism
PDS5B_HUMAN	Q9NTI5	PDS5B	Sister chromatid cohesion protein PDS5 homolog B	0.207768294	0.266880569	0.38998936	1.769905017	0.2373244315	1.0799471885	0.2373244315	1.0799471885	0.21975558992809	0.022148	-1	4.55050995666243	0.022282	1	GO:0000785,chromatin;GO:0005694,chromosome;GO:0000775,chromosome, centromeric region;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003677,DNA binding	GO:0051301,cell division;GO:0008283,cell population proliferation;GO:0006281,DNA repair;GO:0007064,mitotic sister chromatid cohesion;GO:0008285,negative regulation of cell population proliferation;GO:0042127,regulation of cell population proliferation	
HPRT_HUMAN	P00492	HPRT1	Hypoxanthine-guanine phosphoribosyltransferase	3.802556464	2.379144652	2.712237957	5.891594283	3.090850558	4.30191612	3.090850558	4.30191612	0.71848229295554	0.420381	0	1.39182274887585	0.420560	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0052657,guanine phosphoribosyltransferase activity;GO:0004422,hypoxanthine phosphoribosyltransferase activity;GO:0042802,identical protein binding;GO:0000287,magnesium ion binding;GO:0000166,nucleotide binding	GO:0006168,adenine salvage;GO:0021954,central nervous system neuron development;GO:0021895,cerebral cortex neuron differentiation;GO:0048813,dendrite morphogenesis;GO:0042417,dopamine metabolic process;GO:0046038,GMP catabolic process;GO:0032263,GMP salvage;GO:0007625,grooming behavior;GO:0006178,guanine salvage;GO:0046100,hypoxanthine metabolic process;GO:0043103,hypoxanthine salvage;GO:0046040,IMP metabolic process;GO:0032264,IMP salvage;GO:0007626,locomotory behavior;GO:0046651,lymphocyte proliferation;GO:0045964,positive regulation of dopamine metabolic process;GO:0051289,protein homotetramerization;GO:0006164,purine nucleotide biosynthetic process;GO:0006166,purine ribonucleoside salvage;GO:0043101,purine-containing compound salvage;GO:0001975,response to amphetamine;GO:0021756,striatum development;GO:0001913,T cell mediated cytotoxicity	hsa:3251,path:hsa00230,Purine metabolism;hsa:3251,path:hsa00983,Drug metabolism - other enzymes
GPX3_HUMAN	P22352	GPX3	Glutathione peroxidase 3	1.242413787	2.875110092	0.315796046	0.251492525	2.0587619395	0.2836442855	2.0587619395	0.2836442855	7.25825283548679	0.032993	1	0.137774203057633	0.032683	-1	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0004602,glutathione peroxidase activity;GO:0042802,identical protein binding;GO:0004601,peroxidase activity;GO:0008430,selenium binding;GO:0008134,transcription factor binding	GO:0034599,cellular response to oxidative stress;GO:0042744,hydrogen peroxide catabolic process;GO:0006982,response to lipid hydroperoxide;GO:0006979,response to oxidative stress	hsa:2878,path:hsa00590,Arachidonic acid metabolism;hsa:2878,path:hsa00480,Glutathione metabolism;hsa:2878,path:hsa04918,Thyroid hormone synthesis;hsa:2878,path:hsa05014,Amyotrophic lateral sclerosis (ALS);hsa:2878,path:hsa05016,Huntington disease
NUDC2_HUMAN	Q8WVJ2	NUDCD2	NudC domain-containing protein 2	0.136233747	0.341070767	0.087171411	2.55E-05	0.238652257	0.0435984555	0.238652257	0.0435984555	5.47386952732764	0.054721	0	0.182686122679326	0.054313	0	GO:0000777,condensed chromosome kinetochore;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0045171,intercellular bridge;GO:0015630,microtubule cytoskeleton;GO:0005815,microtubule organizing center;GO:0072686,mitotic spindle;GO:0000922,spindle pole	GO:0051082,unfolded protein binding	GO:0006457,protein folding	
SNX12_HUMAN	Q9UMY4	SNX12	Sorting nexin-12	2.377711448	12.79880213	0.391875444	0.137842507	7.588256789	0.2648589755	7.588256789	0.2648589755	28.6501779850009	0.001369	1	0.0349037971255719	0.001338	-1	GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0030904,retromer complex	GO:0019899,enzyme binding;GO:0035091,phosphatidylinositol binding;GO:0032266,phosphatidylinositol-3-phosphate binding	GO:0032456,endocytic recycling;GO:0034499,late endosome to Golgi transport;GO:2000642,negative regulation of early endosome to late endosome transport;GO:0010629,negative regulation of gene expression;GO:0042177,negative regulation of protein catabolic process;GO:0010955,negative regulation of protein processing;GO:0051224,negative regulation of protein transport;GO:0015031,protein transport;GO:0030100,regulation of endocytosis	hsa:29934,path:hsa04144,Endocytosis
SPTN1_HUMAN	Q13813	SPTAN1	Spectrin alpha chain, non-erythrocytic 1	17.76569006	21.42594872	32.97434566	115.0478366	19.59581939	74.01109113	19.59581939	74.01109113	0.264768686568613	0.042128	-1	3.7768816734333	0.042327	1	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1903561,extracellular vesicle;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0015630,microtubule cytoskeleton;GO:0035580,specific granule lumen;GO:0008091,spectrin;GO:1904724,tertiary granule lumen;GO:0005938,cell cortex	GO:0003779,actin binding;GO:0045296,cadherin binding;GO:0005509,calcium ion binding;GO:0005516,calmodulin binding;GO:0005200,structural constituent of cytoskeleton	GO:0051693,actin filament capping;GO:0007411,axon guidance;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0000165,MAPK cascade;GO:0043312,neutrophil degranulation	hsa:6709,path:hsa04210,Apoptosis
UBXN1_HUMAN	Q04323	UBXN1	UBX domain-containing protein 1	0.24870982	0.159500811	0.061914872	0.36874976	0.2041053155	0.215332316	0.2041053155	0.215332316	0.947861980456292	0.451166	0	1.05500591923585	0.451008	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0005783,endoplasmic reticulum;GO:0043025,neuronal cell body;GO:0005654,nucleoplasm;GO:0034098,VCP-NPL4-UFD1 AAA ATPase complex	GO:0051117,ATPase binding;GO:0036435,K48-linked polyubiquitin modification-dependent protein binding;GO:0071796,K6-linked polyubiquitin modification-dependent protein binding;GO:0031593,polyubiquitin modification-dependent protein binding;GO:1904855,proteasome regulatory particle binding;GO:0043130,ubiquitin binding;GO:0031625,ubiquitin protein ligase binding	GO:0006302,double-strand break repair;GO:1904293,negative regulation of ERAD pathway;GO:0032435,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1903094,negative regulation of protein K48-linked deubiquitination;GO:0031397,negative regulation of protein ubiquitination;GO:2000157,negative regulation of ubiquitin-specific protease activity;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006457,protein folding;GO:0016032,viral process	
AP1M1_HUMAN	Q9BXS5	AP1M1	AP-1 complex subunit mu-1	1.360787369	2.523229182	2.188135469	2.030885721	1.9420082755	2.109510595	1.9420082755	2.109510595	0.920596597193199	0.460920	0	1.08625211417128	0.460783	0	GO:0030131,clathrin adaptor complex;GO:0030136,clathrin-coated vesicle;GO:0030665,clathrin-coated vesicle membrane;GO:0031410,cytoplasmic vesicle;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0000139,Golgi membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0035579,specific granule membrane;GO:0032588,trans-Golgi network membrane;GO:0005794,Golgi apparatus	GO:0035615,clathrin adaptor activity	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0035646,endosome to melanosome transport;GO:0006886,intracellular protein transport;GO:0032438,melanosome organization;GO:0043312,neutrophil degranulation;GO:0006892,post-Golgi vesicle-mediated transport;GO:0050690,regulation of defense response to virus by virus;GO:0016192,vesicle-mediated transport;GO:0015031,protein transport	hsa:8907,path:hsa04142,Lysosome;hsa:8907,path:hsa05170,Human immunodeficiency virus 1 infection
SPEE_HUMAN	P19623	SRM	Spermidine synthase	0.795509848	0.50197122	0.914158387	2.55E-05	0.648740534	0.4570919435	0.648740534	0.4570919435	1.41927798821508	0.321691	0	0.704583603989819	0.321275	0	GO:0005829,cytosol	GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:0004766,spermidine synthase activity;GO:0016740,transferase activity	GO:1990830,cellular response to leukemia inhibitory factor;GO:0006596,polyamine biosynthetic process;GO:0006595,polyamine metabolic process;GO:0008295,spermidine biosynthetic process	hsa:6723,path:hsa00270,Cysteine and methionine metabolism;hsa:6723,path:hsa00330,Arginine and proline metabolism;hsa:6723,path:hsa00480,Glutathione metabolism
RPB1_HUMAN	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.116982108	0.053577984	0.115090512	0.394010556	0.085280046	0.254550534	0.085280046	0.254550534	0.335022066777515	0.085834	0	2.98487801003297	0.086116	0	GO:0005694,chromosome;GO:0005737,cytoplasm;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005665,RNA polymerase II, core complex	GO:0003677,DNA binding;GO:0003899,DNA-directed 5'-3' RNA polymerase activity;GO:0019900,kinase binding;GO:0046872,metal ion binding;GO:1990841,promoter-specific chromatin binding;GO:0008022,protein C-terminus binding;GO:0003723,RNA binding;GO:0003968,RNA-directed 5'-3' RNA polymerase activity;GO:0031625,ubiquitin protein ligase binding	GO:0006370,7-methylguanosine mRNA capping;GO:0006353,DNA-templated transcription, termination;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0000398,mRNA splicing, via spliceosome;GO:0048239,negative regulation of DNA recombination at telomere;GO:0033120,positive regulation of RNA splicing;GO:0050434,positive regulation of viral transcription;GO:0060964,regulation of gene silencing by miRNA;GO:0006355,regulation of transcription, DNA-templated;GO:0016070,RNA metabolic process;GO:0042795,snRNA transcription by RNA polymerase II;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter;GO:0006367,transcription initiation from RNA polymerase II promoter;GO:0006351,transcription, DNA-templated;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0016032,viral process	hsa:5430,path:hsa03020,RNA polymerase;hsa:5430,path:hsa05016,Huntington disease
SAM50_HUMAN	Q9Y512	SAMM50	Sorting and assembly machinery component 50 homolog	1.471020433	1.508383847	1.677111335	3.282595871	1.48970214	2.479853603	1.48970214	2.479853603	0.600721808012309	0.317577	0	1.66466405358054	0.317853	0	GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0140275,MIB complex;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0001401,SAM complex		GO:0034622,cellular protein-containing complex assembly;GO:0042407,cristae formation;GO:0007007,inner mitochondrial membrane organization;GO:0033108,mitochondrial respiratory chain complex assembly;GO:0045040,protein insertion into mitochondrial outer membrane	
GLRX3_HUMAN	O76003	GLRX3	Glutaredoxin-3	1.050425752	0.594947151	1.266310508	0.848184724	0.8226864515	1.057247616	0.8226864515	1.057247616	0.778139802870929	0.468508	0	1.28511611449578	0.468634	0	GO:0005938,cell cortex;GO:0005829,cytosol;GO:0030425,dendrite;GO:0005634,nucleus;GO:0030018,Z disc	GO:0042802,identical protein binding;GO:0051536,iron-sulfur cluster binding;GO:0046872,metal ion binding;GO:0015035,protein disulfide oxidoreductase activity;GO:0005080,protein kinase C binding;GO:0003723,RNA binding	GO:0044571,[2Fe-2S] cluster assembly;GO:0006879,cellular iron ion homeostasis;GO:0010614,negative regulation of cardiac muscle hypertrophy;GO:0097428,protein maturation by iron-sulfur cluster transfer;GO:0002026,regulation of the force of heart contraction	
RAB7A_HUMAN	P51149	RAB7A	Ras-related protein Rab-7a	15.20989993	53.75527693	3.233830418	1.409925616	34.48258843	2.321878017	34.48258843	2.321878017	14.851162799049	0.007304	1	0.0673347948258999	0.007192	-1	GO:0000421,autophagosome membrane;GO:0005829,cytosol;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0032419,extrinsic component of lysosome membrane;GO:0005770,late endosome;GO:0031902,late endosome membrane;GO:0005811,lipid droplet;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0033162,melanosome membrane;GO:0045335,phagocytic vesicle;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane	GO:0003925,G protein activity;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:1905394,retromer complex binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0000045,autophagosome assembly;GO:0045022,early endosome to late endosome transport;GO:0006897,endocytosis;GO:0008333,endosome to lysosome transport;GO:0099638,endosome to plasma membrane protein transport;GO:0007174,epidermal growth factor catabolic process;GO:0016042,lipid catabolic process;GO:0061724,lipophagy;GO:1902586,multi-organism intercellular transport;GO:1903542,negative regulation of exosomal secretion;GO:1905366,negative regulation of intralumenal vesicle formation;GO:0043312,neutrophil degranulation;GO:0090383,phagosome acidification;GO:0090382,phagosome maturation;GO:0090385,phagosome-lysosome fusion;GO:1903543,positive regulation of exosomal secretion;GO:0045732,positive regulation of protein catabolic process;GO:0048524,positive regulation of viral process;GO:0006622,protein targeting to lysosome;GO:0022615,protein to membrane docking;GO:0015031,protein transport;GO:0042147,retrograde transport, endosome to Golgi;GO:0034054,suppression by symbiont of host defense-related programmed cell death;GO:0019076,viral release from host cell	hsa:7879,path:hsa04144,Endocytosis;hsa:7879,path:hsa04145,Phagosome;hsa:7879,path:hsa04140,Autophagy - animal;hsa:7879,path:hsa04137,Mitophagy - animal;hsa:7879,path:hsa05132,Salmonella infection;hsa:7879,path:hsa05152,Tuberculosis;hsa:7879,path:hsa05146,Amoebiasis
P4R3A_HUMAN	Q6IN85	PPP4R3A	Serine/threonine-protein phosphatase 4 regulatory subunit 3A	0.02587917	0.010685585	0.120373273	0.09348675	0.0182823775	0.1069300115	0.0182823775	0.1069300115	0.170975175664318	0.008313	-1	5.84880229609087	0.008381	1	GO:0005829,cytosol;GO:0005815,microtubule organizing center;GO:0016607,nuclear speck;GO:0005654,nucleoplasm			hsa:55671,path:hsa04922,Glucagon signaling pathway
LTBP2_HUMAN	Q14767	LTBP2	Latent-transforming growth factor beta-binding protein 2	1.385888737	0.408423172	0.164116336	7.924787007	0.8971559545	4.0444516715	0.8971559545	4.0444516715	0.221823878085126	0.022914	-1	4.50808095427962	0.023052	1	GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0005509,calcium ion binding;GO:0019838,growth factor binding;GO:0008201,heparin binding;GO:0050436,microfibril binding	GO:0009306,protein secretion;GO:0006605,protein targeting;GO:0097435,supramolecular fiber organization;GO:0007179,transforming growth factor beta receptor signaling pathway	
MPU1_HUMAN	O75352	MPDU1	Mannose-P-dolichol utilization defect 1 protein	0.325766697	0.722672862	0.158281345	0.142365819	0.5242197795	0.150323582	0.5242197795	0.150323582	3.48727573229329	0.111102	0	0.286756791480433	0.110563	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane		GO:0006488,dolichol-linked oligosaccharide biosynthetic process;GO:0009312,oligosaccharide biosynthetic process;GO:0006457,protein folding	
ERMP1_HUMAN	Q7Z2K6	ERMP1	Endoplasmic reticulum metallopeptidase 1	6.612379531	2.112634725	2.36014835	4.192500932	4.362507128	3.276324641	4.362507128	3.276324641	1.33152468269093	0.341203	0	0.751018747905642	0.340822	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0046872,metal ion binding;GO:0008235,metalloexopeptidase activity	GO:0034599,cellular response to oxidative stress;GO:0030968,endoplasmic reticulum unfolded protein response;GO:0006508,proteolysis	
RS7_HUMAN	P62081	RPS7	40S ribosomal protein S7	7.621181309	8.816534263	0.783070212	0.351068645	8.218857786	0.5670694285	8.218857786	0.5670694285	14.4935652901274	0.007730	1	0.068996135870114	0.007613	-1	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005815,microtubule organizing center;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:1990904,ribonucleoprotein complex;GO:0005840,ribosome;GO:0032040,small-subunit processome;GO:0045202,synapse	GO:0003730,mRNA 3'-UTR binding;GO:0048027,mRNA 5'-UTR binding;GO:0008266,poly(U) RNA binding;GO:0019901,protein kinase binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome;GO:1990948,ubiquitin ligase inhibitor activity	GO:0030154,cell differentiation;GO:0002181,cytoplasmic translation;GO:1904667,negative regulation of ubiquitin protein ligase activity;GO:2000059,negative regulation of ubiquitin-dependent protein catabolic process;GO:0001843,neural tube closure;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0010628,positive regulation of gene expression;GO:1902255,positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:0050821,protein stabilization;GO:0042274,ribosomal small subunit biogenesis;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6201,path:hsa03010,Ribosome
AAAS_HUMAN	Q9NRG9	AAAS	Aladin	0.308576054	0.162454696	0.378502897	0.286690437	0.235515375	0.332596667	0.235515375	0.332596667	0.708111049711752	0.411713	0	1.41220787390208	0.411901	0	GO:0005813,centrosome;GO:0005829,cytosol;GO:0043657,host cell;GO:0016020,membrane;GO:0072686,mitotic spindle;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0005643,nuclear pore;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000922,spindle pole		GO:0009566,fertilization;GO:0075733,intracellular transport of virus;GO:0007612,learning;GO:0001578,microtubule bundle formation;GO:0090307,mitotic spindle assembly;GO:0006406,mRNA export from nucleus;GO:0006913,nucleocytoplasmic transport;GO:0016925,protein sumoylation;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0046822,regulation of nucleocytoplasmic transport;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription	hsa:8086,path:hsa03013,RNA transport
ANM1_HUMAN	Q99873	PRMT1	Protein arginine N-methyltransferase 1	2.0323281	1.523409584	3.002503676	1.1474956	1.777868842	2.074999638	1.777868842	2.074999638	0.856804410681059	0.485008	0	1.167127511873	0.484925	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0034709,methylosome;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0019899,enzyme binding;GO:0042054,histone methyltransferase activity;GO:0044020,histone methyltransferase activity (H4-R3 specific);GO:0042802,identical protein binding;GO:0008327,methyl-CpG binding;GO:0008168,methyltransferase activity;GO:0048273,mitogen-activated protein kinase p38 binding;GO:0008170,N-methyltransferase activity;GO:0008276,protein methyltransferase activity;GO:0016274,protein-arginine N-methyltransferase activity;GO:0035242,protein-arginine omega-N asymmetric methyltransferase activity;GO:0035241,protein-arginine omega-N monomethyltransferase activity;GO:0003723,RNA binding;GO:1904047,S-adenosyl-L-methionine binding	GO:0007166,cell surface receptor signaling pathway;GO:0006977,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0043985,histone H4-R3 methylation;GO:0016571,histone methylation;GO:0001701,in utero embryonic development;GO:0045653,negative regulation of megakaryocyte differentiation;GO:0031175,neuron projection development;GO:0018216,peptidyl-arginine methylation;GO:0008284,positive regulation of cell population proliferation;GO:0045648,positive regulation of erythrocyte differentiation;GO:0046985,positive regulation of hemoglobin biosynthetic process;GO:1900745,positive regulation of p38MAPK cascade;GO:0051260,protein homooligomerization;GO:0006479,protein methylation;GO:0045652,regulation of megakaryocyte differentiation	hsa:3276,path:hsa04068,FoxO signaling pathway;hsa:3276,path:hsa04922,Glucagon signaling pathway
KLC1_HUMAN	Q07866	KLC1	Kinesin light chain 1	1.063725775	1.020683963	0.848716572	1.473975178	1.042204869	1.161345875	1.042204869	1.161345875	0.897411263461886	0.469464	0	1.11431630147182	0.469346	0	GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0030426,growth cone;GO:0005871,kinesin complex;GO:0016020,membrane;GO:0005874,microtubule;GO:0005737,cytoplasm	GO:0003774,motor activity	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0007018,microtubule-based movement;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0035617,stress granule disassembly;GO:0016032,viral process	hsa:3831,path:hsa05132,Salmonella infection
GLRX1_HUMAN	P35754	GLRX	Glutaredoxin-1	0.877920683	7.961608569	0.81145672	0.730129554	4.419764626	0.770793137	4.419764626	0.770793137	5.73404771506158	0.050519	0	0.174396874545237	0.050126	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0009055,electron transfer activity;GO:0015038,glutathione disulfide oxidoreductase activity;GO:0097573,glutathione oxidoreductase activity;GO:0047485,protein N-terminus binding	GO:0015949,nucleobase-containing small molecule interconversion;GO:0045838,positive regulation of membrane potential;GO:2000651,positive regulation of sodium ion transmembrane transporter activity;GO:0080058,protein deglutathionylation	
THOC2_HUMAN	Q8NI27	THOC2	THO complex subunit 2	0.150128897	0.055182599	0.171310881	0.137943223	0.102655748	0.154627052	0.102655748	0.154627052	0.663892550961911	0.373847	0	1.50626784191373	0.374074	0	GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0000347,THO complex;GO:0000445,THO complex part of transcription export complex;GO:0000346,transcription export complex	GO:0003729,mRNA binding	GO:0048699,generation of neurons;GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0048666,neuron development;GO:0016973,poly(A)+ mRNA export from nucleus;GO:0006405,RNA export from nucleus;GO:0008380,RNA splicing;GO:0046784,viral mRNA export from host cell nucleus;GO:0006397,mRNA processing	hsa:57187,path:hsa03040,Spliceosome;hsa:57187,path:hsa03013,RNA transport
PPIC_HUMAN	P45877	PPIC	Peptidyl-prolyl cis-trans isomerase C	0.361976801	2.757821676	0.068965026	2.55E-05	1.5598992385	0.034495263	1.5598992385	0.034495263	45.2206796770907	0.000362	1	0.0221137764213352	0.000352	-1	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle	GO:0016018,cyclosporin A binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity	GO:0006457,protein folding;GO:0000413,protein peptidyl-prolyl isomerization	
ZNT7_HUMAN	Q8NEW0	SLC30A7	Zinc transporter 7	0.937977092	1.036306326	0.995951326	0.360187478	0.987141709	0.678069402	0.987141709	0.678069402	1.45581220165425	0.314052	0	0.68690178504047	0.313624	0	GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane;GO:0048471,perinuclear region of cytoplasm;GO:0031982,vesicle	GO:0008324,cation transmembrane transporter activity	GO:0032119,sequestering of zinc ion;GO:0006829,zinc ion transport	
DDRGK_HUMAN	Q96HY6	DDRGK1	DDRGK domain-containing protein 1	0.315566387	0.507881982	0.508000624	0.038657321	0.4117241845	0.2733289725	0.4117241845	0.2733289725	1.50633202449843	0.303923	0	0.663864263480009	0.303478	0	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005730,nucleolus	GO:0001103,RNA polymerase II repressing transcription factor binding;GO:0044389,ubiquitin-like protein ligase binding	GO:0051216,cartilage development;GO:0043066,negative regulation of apoptotic process;GO:0010629,negative regulation of gene expression;GO:1903895,negative regulation of IRE1-mediated unfolded protein response;GO:0032435,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1902808,positive regulation of cell cycle G1/S phase transition;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0010628,positive regulation of gene expression;GO:1903721,positive regulation of I-kappaB phosphorylation;GO:1905050,positive regulation of metallopeptidase activity;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:1901800,positive regulation of proteasomal protein catabolic process;GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1905552,positive regulation of protein localization to endoplasmic reticulum;GO:1905636,positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:1990592,protein K69-linked ufmylation;GO:0070972,protein localization to endoplasmic reticulum;GO:0071569,protein ufmylation;GO:0033146,regulation of intracellular estrogen receptor signaling pathway;GO:0031647,regulation of protein stability;GO:0034976,response to endoplasmic reticulum stress;GO:0061709,reticulophagy	
CD59_HUMAN	P13987	CD59	CD59 glycoprotein	1.045690857	4.812324989	0.163344204	0.052832586	2.929007923	0.108088395	2.929007923	0.108088395	27.0982645546731	0.001595	1	0.0369027322019982	0.001561	-1	GO:0031362,anchored component of external side of plasma membrane;GO:0009986,cell surface;GO:0005789,endoplasmic reticulum membrane;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0000139,Golgi membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0035579,specific granule membrane;GO:0070821,tertiary granule membrane;GO:0030133,transport vesicle;GO:0031982,vesicle;GO:0031225,anchored component of membrane	GO:0001848,complement binding	GO:0007596,blood coagulation;GO:0007166,cell surface receptor signaling pathway;GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0001971,negative regulation of activation of membrane attack complex;GO:0043312,neutrophil degranulation;GO:0030449,regulation of complement activation;GO:1903659,regulation of complement-dependent cytotoxicity	hsa:966,path:hsa04640,Hematopoietic cell lineage;hsa:966,path:hsa04610,Complement and coagulation cascades
INF2_HUMAN	Q27J81	INF2	Inverted formin-2	4.227037895	3.280487154	4.744654031	4.790427428	3.7537625245	4.7675407295	3.7537625245	4.7675407295	0.787358249772872	0.475670	0	1.27006988278648	0.475789	0	GO:0048471,perinuclear region of cytoplasm	GO:0003779,actin binding;GO:0031267,small GTPase binding	GO:0030036,actin cytoskeleton organization;GO:0090140,regulation of mitochondrial fission	
CMA1_HUMAN	P23946	CMA1	Chymase	2.55E-05	0.053497231	0.063885245	0.857474606	0.0267613655	0.4606799255	0.0267613655	0.4606799255	0.0580910172522809	0.000026	-1	17.2143654440951	0.000027	1	GO:0062023,collagen-containing extracellular matrix;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0030141,secretory granule	GO:0042277,peptide binding;GO:0004252,serine-type endopeptidase activity;GO:0008236,serine-type peptidase activity	GO:0002003,angiotensin maturation;GO:0034769,basement membrane disassembly;GO:0071333,cellular response to glucose stimulus;GO:0140447,cytokine precursor processing;GO:0022617,extracellular matrix disassembly;GO:0030901,midbrain development;GO:0045766,positive regulation of angiogenesis;GO:0050727,regulation of inflammatory response	hsa:1215,path:hsa04614,Renin-angiotensin system
ANK2_HUMAN	Q01484	ANK2	Ankyrin-2	2.55E-05	2.55E-05	0.112999699	2.55E-05	2.55e-005	0.0565125995	2.55e-005	0.0565125995	0.000451226810049678	0.000000	-1	2216.18037254902	0.000000	1	GO:0031672,A band;GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0043034,costamere;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005769,early endosome;GO:0014704,intercalated disc;GO:0005764,lysosome;GO:0031430,M band;GO:0005739,mitochondrion;GO:0043005,neuron projection;GO:0005886,plasma membrane;GO:0045211,postsynaptic membrane;GO:0055037,recycling endosome;GO:0042383,sarcolemma;GO:0030315,T-tubule;GO:0030018,Z disc;GO:0016020,membrane;GO:0045121,membrane raft	GO:0051117,ATPase binding;GO:0008093,cytoskeletal anchor activity;GO:0019899,enzyme binding;GO:0044325,ion channel binding;GO:0140031,phosphorylation-dependent protein binding;GO:0019901,protein kinase binding;GO:0030674,protein-macromolecule adaptor activity;GO:0030507,spectrin binding;GO:0005200,structural constituent of cytoskeleton	GO:0086014,atrial cardiac muscle cell action potential;GO:0086066,atrial cardiac muscle cell to AV node cell communication;GO:0003283,atrial septum development;GO:0006874,cellular calcium ion homeostasis;GO:0034613,cellular protein localization;GO:0006897,endocytosis;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0086046,membrane depolarization during SA node cell action potential;GO:1901021,positive regulation of calcium ion transmembrane transporter activity;GO:0051928,positive regulation of calcium ion transport;GO:2001259,positive regulation of cation channel activity;GO:0010628,positive regulation of gene expression;GO:1901018,positive regulation of potassium ion transmembrane transporter activity;GO:0043268,positive regulation of potassium ion transport;GO:0034394,protein localization to cell surface;GO:0070972,protein localization to endoplasmic reticulum;GO:0036309,protein localization to M-band;GO:0033365,protein localization to organelle;GO:0072659,protein localization to plasma membrane;GO:0036371,protein localization to T-tubule;GO:0050821,protein stabilization;GO:0015031,protein transport;GO:0098910,regulation of atrial cardiac muscle cell action potential;GO:1901019,regulation of calcium ion transmembrane transporter activity;GO:0051924,regulation of calcium ion transport;GO:0086004,regulation of cardiac muscle cell contraction;GO:0055117,regulation of cardiac muscle contraction;GO:0010882,regulation of cardiac muscle contraction by calcium ion signaling;GO:0010881,regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0002027,regulation of heart rate;GO:0086091,regulation of heart rate by cardiac conduction;GO:0031647,regulation of protein stability;GO:0051279,regulation of release of sequestered calcium ion into cytosol;GO:0098907,regulation of SA node cell action potential;GO:0060307,regulation of ventricular cardiac muscle cell membrane repolarization;GO:0086015,SA node cell action potential;GO:0086070,SA node cell to atrial cardiac muscle cell communication;GO:0070296,sarcoplasmic reticulum calcium ion transport;GO:0033292,T-tubule organization;GO:0086005,ventricular cardiac muscle cell action potential;GO:0007165,signal transduction;GO:0030913,paranodal junction assembly;GO:0051597,response to methylmercury	hsa:287,path:hsa05205,Proteoglycans in cancer
FADD_HUMAN	Q13158	FADD	FAS-associated death domain protein	2.55E-05	0.017486332	0.027856419	2.55E-05	0.008755916	0.0139409595	0.008755916	0.0139409595	0.628071260087944	0.342208	0	1.59217602133232	0.342463	0	GO:0031265,CD95 death-inducing signaling complex;GO:0044297,cell body;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0031264,death-inducing signaling complex;GO:0045121,membrane raft;GO:0043005,neuron projection;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0097342,ripoptosome	GO:0089720,caspase binding;GO:0035877,death effector domain binding;GO:0005123,death receptor binding;GO:0042802,identical protein binding;GO:0002020,protease binding;GO:0044877,protein-containing complex binding;GO:0033612,receptor serine/threonine kinase binding;GO:0005164,tumor necrosis factor receptor binding;GO:0032813,tumor necrosis factor receptor superfamily binding	GO:0097202,activation of cysteine-type endopeptidase activity;GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006915,apoptotic process;GO:0097190,apoptotic signaling pathway;GO:0048148,behavioral response to cocaine;GO:0007166,cell surface receptor signaling pathway;GO:0071260,cellular response to mechanical stimulus;GO:0071550,death-inducing signaling complex assembly;GO:0051607,defense response to virus;GO:0097191,extrinsic apoptotic signaling pathway;GO:0097192,extrinsic apoptotic signaling pathway in absence of ligand;GO:0008625,extrinsic apoptotic signaling pathway via death domain receptors;GO:0045087,innate immune response;GO:0001822,kidney development;GO:0048535,lymph node development;GO:0097049,motor neuron apoptotic process;GO:0097527,necroptotic signaling pathway;GO:0070236,negative regulation of activation-induced cell death of T cells;GO:1902042,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0060546,negative regulation of necroptotic process;GO:0042104,positive regulation of activated T cell proliferation;GO:0002821,positive regulation of adaptive immune response;GO:0043065,positive regulation of apoptotic process;GO:2000454,positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation;GO:2001238,positive regulation of extrinsic apoptotic signaling pathway;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0032729,positive regulation of interferon-gamma production;GO:0032757,positive regulation of interleukin-8 production;GO:0045651,positive regulation of macrophage differentiation;GO:0045862,positive regulation of proteolysis;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0032760,positive regulation of tumor necrosis factor production;GO:0060340,positive regulation of type I interferon-mediated signaling pathway;GO:1902041,regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0010803,regulation of tumor necrosis factor-mediated signaling pathway;GO:0043278,response to morphine;GO:0048536,spleen development;GO:0033077,T cell differentiation in thymus;GO:0043029,T cell homeostasis;GO:0048538,thymus development;GO:0034138,toll-like receptor 3 signaling pathway;GO:0036462,TRAIL-activated apoptotic signaling pathway;GO:0035666,TRIF-dependent toll-like receptor signaling pathway;GO:0016032,viral process	hsa:8772,path:hsa04668,TNF signaling pathway;hsa:8772,path:hsa04210,Apoptosis;hsa:8772,path:hsa04215,Apoptosis - multiple species;hsa:8772,path:hsa04217,Necroptosis;hsa:8772,path:hsa04620,Toll-like receptor signaling pathway;hsa:8772,path:hsa04621,NOD-like receptor signaling pathway;hsa:8772,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:8772,path:hsa04657,IL-17 signaling pathway;hsa:8772,path:hsa05200,Pathways in cancer;hsa:8772,path:hsa05010,Alzheimer disease;hsa:8772,path:hsa05130,Pathogenic Escherichia coli infection;hsa:8772,path:hsa05132,Salmonella infection;hsa:8772,path:hsa05152,Tuberculosis;hsa:8772,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:8772,path:hsa05162,Measles;hsa:8772,path:hsa05164,Influenza A;hsa:8772,path:hsa05161,Hepatitis B;hsa:8772,path:hsa05160,Hepatitis C;hsa:8772,path:hsa05168,Herpes simplex virus 1 infection;hsa:8772,path:hsa05163,Human cytomegalovirus infection;hsa:8772,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:8772,path:hsa05169,Epstein-Barr virus infection;hsa:8772,path:hsa05165,Human papillomavirus infection;hsa:8772,path:hsa05142,Chagas disease (American trypanosomiasis);hsa:8772,path:hsa01524,Platinum drug resistance
MAOX_HUMAN	P48163	ME1	NADP-dependent malic enzyme	1.196539296	0.409351988	1.718740553	0.65142637	0.802945642	1.1850834615	0.802945642	1.1850834615	0.677543538565364	0.385688	0	1.47591991227222	0.385903	0	GO:0005829,cytosol;GO:0005739,mitochondrion	GO:0043531,ADP binding;GO:0009055,electron transfer activity;GO:0042802,identical protein binding;GO:0004471,malate dehydrogenase (decarboxylating) (NAD+) activity;GO:0004473,malate dehydrogenase (decarboxylating) (NADP+) activity;GO:0004470,malic enzyme activity;GO:0030145,manganese ion binding;GO:0051287,NAD binding;GO:0050661,NADP binding;GO:0008948,oxaloacetate decarboxylase activity	GO:0005975,carbohydrate metabolic process;GO:0006108,malate metabolic process;GO:0009165,nucleotide biosynthetic process;GO:0006090,pyruvate metabolic process;GO:0019222,regulation of metabolic process;GO:1902031,regulation of NADP metabolic process;GO:0009743,response to carbohydrate;GO:0009725,response to hormone	hsa:4199,path:hsa00620,Pyruvate metabolism;hsa:4199,path:hsa03320,PPAR signaling pathway
PSA3_HUMAN	P25788	PSMA3	Proteasome subunit alpha type-3	6.478682976	5.902981543	5.351503148	3.361479637	6.1908322595	4.3564913925	6.1908322595	4.3564913925	1.42105921984787	0.321312	0	0.70370044121529	0.320896	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000502,proteasome complex;GO:0005839,proteasome core complex;GO:0019773,proteasome core complex, alpha-subunit complex;GO:0045202,synapse	GO:0004175,endopeptidase activity;GO:0031625,ubiquitin protein ligase binding	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:0052548,regulation of endopeptidase activity;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0051603,proteolysis involved in cellular protein catabolic process	hsa:5684,path:hsa03050,Proteasome
ACTB_HUMAN	P60709	ACTB	Actin, cytoplasmic 1	1500.771331	2470.742633	1431.04418	2663.646245	1985.756982	2047.3452125	1985.756982	2047.3452125	0.969918003996603	0.443499	0	1.03101498877167	0.443324	0	GO:0015629,actin cytoskeleton;GO:0005884,actin filament;GO:0005912,adherens junction;GO:0043296,apical junction complex;GO:0030424,axon;GO:0072562,blood microparticle;GO:0005911,cell-cell junction;GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0097433,dense body;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0030027,lamellipodium;GO:0016020,membrane;GO:0035267,NuA4 histone acetyltransferase complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0098871,postsynaptic actin cytoskeleton;GO:0098793,presynapse;GO:0032991,protein-containing complex;GO:1990904,ribonucleoprotein complex;GO:0045202,synapse;GO:0070160,tight junction;GO:0031982,vesicle	GO:0005524,ATP binding;GO:0042802,identical protein binding;GO:0019894,kinesin binding;GO:0050998,nitric-oxide synthase binding;GO:0019901,protein kinase binding;GO:0005200,structural constituent of cytoskeleton;GO:0098973,structural constituent of postsynaptic actin cytoskeleton;GO:0030957,Tat protein binding;GO:0048156,tau protein binding	GO:0034333,adherens junction assembly;GO:0045176,apical protein localization;GO:0043044,ATP-dependent chromatin remodeling;GO:0007409,axonogenesis;GO:0034329,cell junction assembly;GO:0048870,cell motility;GO:0072749,cellular response to cytochalasin B;GO:0048013,ephrin receptor signaling pathway;GO:0007163,establishment or maintenance of cell polarity;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0035633,maintenance of blood-brain barrier;GO:0061024,membrane organization;GO:0001738,morphogenesis of a polarized epithelium;GO:0032091,negative regulation of protein binding;GO:0070527,platelet aggregation;GO:0045815,positive regulation of gene expression, epigenetic;GO:0051623,positive regulation of norepinephrine uptake;GO:0098974,postsynaptic actin cytoskeleton organization;GO:0016579,protein deubiquitination;GO:0071896,protein localization to adherens junction;GO:0000079,regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0051621,regulation of norepinephrine uptake;GO:1903076,regulation of protein localization to plasma membrane;GO:0150111,regulation of transepithelial transport;GO:0022898,regulation of transmembrane transporter activity;GO:0001895,retina homeostasis;GO:0021762,substantia nigra development	hsa:60,path:hsa04015,Rap1 signaling pathway;hsa:60,path:hsa04390,Hippo signaling pathway;hsa:60,path:hsa04145,Phagosome;hsa:60,path:hsa04210,Apoptosis;hsa:60,path:hsa04510,Focal adhesion;hsa:60,path:hsa04520,Adherens junction;hsa:60,path:hsa04530,Tight junction;hsa:60,path:hsa04810,Regulation of actin cytoskeleton;hsa:60,path:hsa04611,Platelet activation;hsa:60,path:hsa04670,Leukocyte transendothelial migration;hsa:60,path:hsa04921,Oxytocin signaling pathway;hsa:60,path:hsa04919,Thyroid hormone signaling pathway;hsa:60,path:hsa04971,Gastric acid secretion;hsa:60,path:hsa04714,Thermogenesis;hsa:60,path:hsa05205,Proteoglycans in cancer;hsa:60,path:hsa05225,Hepatocellular carcinoma;hsa:60,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:60,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:60,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:60,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:60,path:hsa05416,Viral myocarditis;hsa:60,path:hsa05110,Vibrio cholerae infection;hsa:60,path:hsa05130,Pathogenic Escherichia coli infection;hsa:60,path:hsa05132,Salmonella infection;hsa:60,path:hsa05131,Shigellosis;hsa:60,path:hsa05135,Yersinia infection;hsa:60,path:hsa05100,Bacterial invasion of epithelial cells;hsa:60,path:hsa05164,Influenza A
HNRPU_HUMAN	Q00839	HNRNPU	Heterogeneous nuclear ribonucleoprotein U	19.19708872	18.18327503	25.25948678	13.15028174	18.690181875	19.20488426	18.690181875	19.20488426	0.973199401879655	0.442375	0	1.02753865042311	0.442197	0	GO:0071013,catalytic step 2 spliceosome;GO:0009986,cell surface;GO:0005813,centrosome;GO:0000777,condensed chromosome kinetochore;GO:0070937,CRD-mediated mRNA stability complex;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0032839,dendrite cytoplasm;GO:0098577,inactive sex chromosome;GO:0000776,kinetochore;GO:0016020,membrane;GO:0030496,midbody;GO:0072686,mitotic spindle;GO:1990498,mitotic spindle microtubule;GO:1990023,mitotic spindle midzone;GO:0000228,nuclear chromosome;GO:0016363,nuclear matrix;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:1990904,ribonucleoprotein complex;GO:0000922,spindle pole;GO:0005697,telomerase holoenzyme complex;GO:0016021,integral component of membrane	GO:0003779,actin binding;GO:0005524,ATP binding;GO:0003682,chromatin binding;GO:0031490,chromatin DNA binding;GO:0003677,DNA binding;GO:0003690,double-stranded DNA binding;GO:0003725,double-stranded RNA binding;GO:0042802,identical protein binding;GO:0003730,mRNA 3'-UTR binding;GO:0008143,poly(A) binding;GO:0017130,poly(C) RNA binding;GO:0034046,poly(G) binding;GO:0036002,pre-mRNA binding;GO:1990841,promoter-specific chromatin binding;GO:0044877,protein-containing complex binding;GO:0043021,ribonucleoprotein complex binding;GO:0003723,RNA binding;GO:0099122,RNA polymerase II C-terminal domain binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000993,RNA polymerase II complex binding;GO:1990837,sequence-specific double-stranded DNA binding;GO:0003697,single-stranded DNA binding;GO:0003727,single-stranded RNA binding;GO:0017069,snRNA binding;GO:0070034,telomerase RNA binding;GO:0001097,TFIIH-class transcription factor complex binding;GO:0003714,transcription corepressor activity	GO:1990845,adaptive thermogenesis;GO:0055013,cardiac muscle cell development;GO:0007049,cell cycle;GO:0051301,cell division;GO:0071385,cellular response to glucocorticoid stimulus;GO:1990830,cellular response to leukemia inhibitory factor;GO:0006325,chromatin organization;GO:0032922,circadian regulation of gene expression;GO:0070934,CRD-mediated mRNA stabilization;GO:0098963,dendritic transport of messenger ribonucleoprotein complex;GO:0009048,dosage compensation by inactivation of X chromosome;GO:0051457,maintenance of protein location in nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0048255,mRNA stabilization;GO:0033673,negative regulation of kinase activity;GO:2000737,negative regulation of stem cell differentiation;GO:0032211,negative regulation of telomere maintenance via telomerase;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0034244,negative regulation of transcription elongation from RNA polymerase II promoter;GO:0001649,osteoblast differentiation;GO:1902425,positive regulation of attachment of mitotic spindle microtubules to kinetochore;GO:0090336,positive regulation of brown fat cell differentiation;GO:2000373,positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity;GO:2000648,positive regulation of stem cell proliferation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:1902889,protein localization to spindle microtubule;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:1902275,regulation of chromatin organization;GO:0007346,regulation of mitotic cell cycle;GO:1901673,regulation of mitotic spindle assembly;GO:1990280,RNA localization to chromatin;GO:0016070,RNA metabolic process;GO:0006396,RNA processing;GO:0016032,viral process	hsa:3192,path:hsa03040,Spliceosome
LDHB_HUMAN	P07195	LDHB	L-lactate dehydrogenase B chain	15.10266193	22.20048827	31.59174277	25.55000391	18.6515751	28.57087334	18.6515751	28.57087334	0.652817814773876	0.364150	0	1.53182094202864	0.364385	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0045121,membrane raft	GO:0042802,identical protein binding;GO:0004459,L-lactate dehydrogenase activity;GO:0016616,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO:0005975,carbohydrate metabolic process;GO:0006090,pyruvate metabolic process;GO:0019752,carboxylic acid metabolic process	hsa:3945,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:3945,path:hsa00620,Pyruvate metabolism;hsa:3945,path:hsa00640,Propanoate metabolism;hsa:3945,path:hsa00270,Cysteine and methionine metabolism;hsa:3945,path:hsa04066,HIF-1 signaling pathway;hsa:3945,path:hsa04922,Glucagon signaling pathway;hsa:3945,path:hsa05230,Central carbon metabolism in cancer
ICAL_HUMAN	P20810	CAST	Calpastatin	0.220532511	0.275233896	0.342215489	0.449925545	0.2478832035	0.396070517	0.2478832035	0.396070517	0.625856237362904	0.340227	0	1.59781103119397	0.340483	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0016020,membrane	GO:0045296,cadherin binding;GO:0010859,calcium-dependent cysteine-type endopeptidase inhibitor activity;GO:0004866,endopeptidase inhibitor activity;GO:0003723,RNA binding	GO:0097340,inhibition of cysteine-type endopeptidase activity;GO:2000675,negative regulation of type B pancreatic cell apoptotic process;GO:1990709,presynaptic active zone organization	hsa:831,path:hsa05131,Shigellosis
MCCB_HUMAN	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	0.709580373	0.818851166	1.619519179	1.872473934	0.7642157695	1.7459965565	0.7642157695	1.7459965565	0.437696034768783	0.168949	0	2.28469056277437	0.169284	0	GO:0002169,3-methylcrotonyl-CoA carboxylase complex, mitochondrial;GO:0005829,cytosol;GO:1905202,methylcrotonoyl-CoA carboxylase complex;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0004485,methylcrotonoyl-CoA carboxylase activity;GO:0016874,ligase activity	GO:0006768,biotin metabolic process;GO:0009083,branched-chain amino acid catabolic process;GO:0015936,coenzyme A metabolic process;GO:0006552,leucine catabolic process	hsa:64087,path:hsa00280,Valine, leucine and isoleucine degradation
FBLN3_HUMAN	Q12805	EFEMP1	EGF-containing fibulin-like extracellular matrix protein 1	1.13585691	1.533237008	1.22591174	3.351652225	1.334546959	2.2887819825	1.334546959	2.2887819825	0.583081730459227	0.301521	0	1.71502543770736	0.301808	0	GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0005509,calcium ion binding;GO:0005154,epidermal growth factor receptor binding;GO:0005006,epidermal growth factor-activated receptor activity;GO:0008083,growth factor activity	GO:0043010,camera-type eye development;GO:0048048,embryonic eye morphogenesis;GO:0007173,epidermal growth factor receptor signaling pathway;GO:0032331,negative regulation of chondrocyte differentiation;GO:0018108,peptidyl-tyrosine phosphorylation;GO:0048050,post-embryonic eye morphogenesis;GO:0006355,regulation of transcription, DNA-templated;GO:0007601,visual perception	
PLD3_HUMAN	Q8IV08	PLD3	5'-3' exonuclease PLD3	2.431207021	3.130627264	6.421438884	4.725771073	2.7809171425	5.5736049785	2.7809171425	5.5736049785	0.498944068197746	0.224172	0	2.00423266602234	0.224501	0	GO:0031901,early endosome membrane;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0031902,late endosome membrane;GO:0043202,lysosomal lumen;GO:0005765,lysosomal membrane	GO:0004630,phospholipase D activity;GO:0045145,single-stranded DNA 5'-3' exodeoxyribonuclease activity;GO:0003824,catalytic activity	GO:0002376,immune system process;GO:0006954,inflammatory response;GO:0014902,myotube differentiation;GO:1900015,regulation of cytokine production involved in inflammatory response;GO:0016042,lipid catabolic process	hsa:23646,path:hsa00564,Glycerophospholipid metabolism;hsa:23646,path:hsa00565,Ether lipid metabolism
SC61B_HUMAN	P60468	SEC61B	Protein transport protein Sec61 subunit beta	1.282737898	11.29000391	0.751192033	2.55E-05	6.286370904	0.3756087665	6.286370904	0.3756087665	16.7364861118064	0.005500	1	0.0597496985519899	0.005409	-1	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0044322,endoplasmic reticulum quality control compartment;GO:0031205,endoplasmic reticulum Sec complex;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005784,Sec61 translocon complex	GO:0048408,epidermal growth factor binding;GO:0043022,ribosome binding;GO:0003723,RNA binding	GO:0031204,posttranslational protein targeting to membrane, translocation;GO:0045048,protein insertion into ER membrane;GO:0030970,retrograde protein transport, ER to cytosol;GO:0006616,SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0006886,intracellular protein transport	hsa:10952,path:hsa03060,Protein export;hsa:10952,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:10952,path:hsa04145,Phagosome;hsa:10952,path:hsa05110,Vibrio cholerae infection
FKB10_HUMAN	Q96AY3	FKBP10	Peptidyl-prolyl cis-trans isomerase FKBP10	2.863066407	2.751901615	1.951500511	1.461758519	2.807484011	1.706629515	2.807484011	1.706629515	1.64504597296854	0.278468	0	0.607885746922603	0.277985	0	GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0016020,membrane;GO:0005758,mitochondrial intermembrane space	GO:0005509,calcium ion binding;GO:0005528,FK506 binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity	GO:0035909,aorta morphogenesis;GO:0030199,collagen fibril organization;GO:0085029,extracellular matrix assembly;GO:0001701,in utero embryonic development;GO:0017185,peptidyl-lysine hydroxylation;GO:0018208,peptidyl-proline modification;GO:0042060,wound healing	
PKP1_HUMAN	Q13835	PKP1	Plakophilin-1	1.842686058	1.85224505	2.357231177	4.5899908	1.847465554	3.4736109885	1.847465554	3.4736109885	0.531857355390791	0.254449	0	1.88020338510734	0.254765	0	GO:0005912,adherens junction;GO:0001533,cornified envelope;GO:0005737,cytoplasm;GO:0030057,desmosome;GO:0101003,ficolin-1-rich granule membrane;GO:0005882,intermediate filament;GO:1990124,messenger ribonucleoprotein complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0045296,cadherin binding;GO:0019215,intermediate filament binding;GO:0005521,lamin binding;GO:0030280,structural constituent of skin epidermis	GO:0007155,cell adhesion;GO:0098609,cell-cell adhesion;GO:0007043,cell-cell junction assembly;GO:0070268,cornification;GO:0045110,intermediate filament bundle assembly;GO:0031424,keratinization;GO:1902373,negative regulation of mRNA catabolic process;GO:0043312,neutrophil degranulation;GO:0010628,positive regulation of gene expression;GO:0007165,signal transduction	
CO8B_HUMAN	P07358	C8B	Complement component C8 beta chain	0.501845262	0.216347181	0.691571996	1.518705082	0.3590962215	1.105138539	0.3590962215	1.105138539	0.324933217716698	0.078741	0	3.07755546517217	0.079013	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1903561,extracellular vesicle;GO:0016020,membrane;GO:0005579,membrane attack complex	GO:0044877,protein-containing complex binding	GO:0006956,complement activation;GO:0006957,complement activation, alternative pathway;GO:0006958,complement activation, classical pathway;GO:0019835,cytolysis;GO:0006955,immune response;GO:0030449,regulation of complement activation;GO:0045087,innate immune response	hsa:732,path:hsa04610,Complement and coagulation cascades;hsa:732,path:hsa05322,Systemic lupus erythematosus;hsa:732,path:hsa05020,Prion diseases;hsa:732,path:hsa05146,Amoebiasis
RAB4A_HUMAN	P20338	RAB4A	Ras-related protein Rab-4A	0.605949747	1.421950004	0.618115673	0.50451659	1.0139498755	0.5613161315	1.0139498755	0.5613161315	1.80637936200129	0.252624	0	0.553593570119236	0.252109	0	GO:0098993,anchored component of synaptic vesicle membrane;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0032593,insulin-responsive compartment;GO:0043231,intracellular membrane-bounded organelle;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0098837,postsynaptic recycling endosome;GO:0055038,recycling endosome membrane;GO:0031982,vesicle	GO:0001671,ATPase activator activity;GO:0051117,ATPase binding;GO:0003925,G protein activity;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0035255,ionotropic glutamate receptor binding;GO:0019905,syntaxin binding	GO:0019882,antigen processing and presentation;GO:0006661,phosphatidylinositol biosynthetic process;GO:0015031,protein transport;GO:0032482,Rab protein signal transduction;GO:0030100,regulation of endocytosis	hsa:5867,path:hsa04144,Endocytosis
PRP4_HUMAN	O43172	PRPF4	U4/U6 small nuclear ribonucleoprotein Prp4	0.525596531	0.546425481	0.971408596	1.079541382	0.536011006	1.025474989	0.536011006	1.025474989	0.522695347765327	0.246007	0	1.91316032230876	0.246327	0	GO:0015030,Cajal body;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0097525,spliceosomal snRNP complex;GO:0071005,U2-type precatalytic spliceosome;GO:0071001,U4/U6 snRNP;GO:0046540,U4/U6 x U5 tri-snRNP complex	GO:0030621,U4 snRNA binding;GO:0017070,U6 snRNA binding	GO:0000398,mRNA splicing, via spliceosome;GO:0006396,RNA processing;GO:0008380,RNA splicing;GO:0000375,RNA splicing, via transesterification reactions	hsa:9128,path:hsa03040,Spliceosome
S10A9_HUMAN	P06702	S100A9	Protein S100-A9	6.441122526	212.7861067	3.13928643	4.289785638	109.613614613	3.714536034	109.613614613	3.714536034	29.5093690328163	0.001261	1	0.0338875425932671	0.001233	-1	GO:0030054,cell junction;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0034774,secretory granule lumen	GO:0016209,antioxidant activity;GO:0050544,arachidonic acid binding;GO:0005509,calcium ion binding;GO:0048306,calcium-dependent protein binding;GO:0008017,microtubule binding;GO:0050786,RAGE receptor binding;GO:0035662,Toll-like receptor 4 binding;GO:0008270,zinc ion binding	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0019730,antimicrobial humoral response;GO:0006915,apoptotic process;GO:0014002,astrocyte development;GO:0035425,autocrine signaling;GO:0006914,autophagy;GO:0007267,cell-cell signaling;GO:0002544,chronic inflammatory response;GO:0042742,defense response to bacterium;GO:0050832,defense response to fungus;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0002523,leukocyte migration involved in inflammatory response;GO:0035821,modulation of process of other organism;GO:0070488,neutrophil aggregation;GO:0030593,neutrophil chemotaxis;GO:0043312,neutrophil degranulation;GO:0018119,peptidyl-cysteine S-nitrosylation;GO:0035606,peptidyl-cysteine S-trans-nitrosylation;GO:0030307,positive regulation of cell growth;GO:0050729,positive regulation of inflammatory response;GO:2001244,positive regulation of intrinsic apoptotic signaling pathway;GO:0010976,positive regulation of neuron projection development;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0051493,regulation of cytoskeleton organization;GO:0045113,regulation of integrin biosynthetic process;GO:0032496,response to lipopolysaccharide;GO:0032119,sequestering of zinc ion;GO:0002224,toll-like receptor signaling pathway	hsa:6280,path:hsa04657,IL-17 signaling pathway
MRP3_HUMAN	O15438	ABCC3	ATP-binding cassette sub-family C member 3	2.55E-05	0.049494927	0.031213057	2.55E-05	0.0247602135	0.0156192785	0.0247602135	0.0156192785	1.58523413869597	0.289043	0	0.6308216405323	0.288576	0	GO:0016323,basolateral plasma membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0015432,ABC-type bile acid transporter activity;GO:0015431,ABC-type glutathione S-conjugate transporter activity;GO:0008559,ABC-type xenobiotic transporter activity;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0042626,ATPase-coupled transmembrane transporter activity;GO:0015164,glucuronoside transmembrane transporter activity;GO:0071714,icosanoid transmembrane transporter activity;GO:0042910,xenobiotic transmembrane transporter activity	GO:0015721,bile acid and bile salt transport;GO:0015722,canalicular bile acid transport;GO:0006855,drug transmembrane transport;GO:0071716,leukotriene transport;GO:0055085,transmembrane transport;GO:0150104,transport across blood-brain barrier;GO:0042908,xenobiotic transport	hsa:8714,path:hsa02010,ABC transporters;hsa:8714,path:hsa04976,Bile secretion;hsa:8714,path:hsa01523,Antifolate resistance
AL9A1_HUMAN	P49189	ALDH9A1	4-trimethylaminobutyraldehyde dehydrogenase	4.571821949	8.766870812	9.446989039	9.831958524	6.6693463805	9.6394737815	6.6693463805	9.6394737815	0.691878678408748	0.397980	0	1.445340102545	0.398182	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0033737,1-pyrroline dehydrogenase activity;GO:0047105,4-trimethylammoniobutyraldehyde dehydrogenase activity;GO:0004029,aldehyde dehydrogenase (NAD+) activity;GO:0019145,aminobutyraldehyde dehydrogenase activity;GO:0043878,glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	GO:0045329,carnitine biosynthetic process;GO:0006081,cellular aldehyde metabolic process;GO:0042445,hormone metabolic process;GO:0042136,neurotransmitter biosynthetic process;GO:0051289,protein homotetramerization	hsa:223,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:223,path:hsa00053,Ascorbate and aldarate metabolism;hsa:223,path:hsa00620,Pyruvate metabolism;hsa:223,path:hsa00071,Fatty acid degradation;hsa:223,path:hsa00561,Glycerolipid metabolism;hsa:223,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:223,path:hsa00310,Lysine degradation;hsa:223,path:hsa00330,Arginine and proline metabolism;hsa:223,path:hsa00340,Histidine metabolism;hsa:223,path:hsa00380,Tryptophan metabolism;hsa:223,path:hsa00410,beta-Alanine metabolism
ENOG_HUMAN	P09104	ENO2	Gamma-enolase	1.385114284	0.397837816	1.740919891	3.433900527	0.89147605	2.587410209	0.89147605	2.587410209	0.344543763064359	0.092746	0	2.90238891891712	0.093036	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0016020,membrane;GO:0043204,perikaryon;GO:0000015,phosphopyruvate hydratase complex;GO:0001917,photoreceptor inner segment;GO:0005886,plasma membrane	GO:0000287,magnesium ion binding;GO:0004634,phosphopyruvate hydratase activity	GO:0061621,canonical glycolysis;GO:0006094,gluconeogenesis;GO:0006096,glycolytic process;GO:0032889,regulation of vacuole fusion, non-autophagic	hsa:2026,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:2026,path:hsa03018,RNA degradation;hsa:2026,path:hsa04066,HIF-1 signaling pathway
S27A4_HUMAN	Q6P1M0	SLC27A4	Long-chain fatty acid transport protein 4	0.049461259	0.109791786	0.145996389	2.55E-05	0.0796265225	0.0730109445	0.0796265225	0.0730109445	1.09061077137552	0.404794	0	0.916917406508616	0.404537	0	GO:0031526,brush border membrane;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005902,microvillus;GO:0005886,plasma membrane	GO:0047676,arachidonate-CoA ligase activity;GO:0005324,long-chain fatty acid transporter activity;GO:0004467,long-chain fatty acid-CoA ligase activity;GO:0000166,nucleotide binding;GO:1901480,oleate transmembrane transporter activity;GO:0090434,oleoyl-CoA ligase activity;GO:0090433,palmitoyl-CoA ligase activity;GO:0031957,very long-chain fatty acid-CoA ligase activity	GO:0090630,activation of GTPase activity;GO:0006631,fatty acid metabolic process;GO:0015908,fatty acid transport;GO:0044381,glucose import in response to insulin stimulus;GO:1990379,lipid transport across blood-brain barrier;GO:0044539,long-chain fatty acid import into cell;GO:0001676,long-chain fatty acid metabolic process;GO:0015909,long-chain fatty acid transport;GO:0001579,medium-chain fatty acid transport;GO:0062003,negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity;GO:0046627,negative regulation of insulin receptor signaling pathway;GO:0043065,positive regulation of apoptotic process;GO:0007584,response to nutrient;GO:0043588,skin development;GO:0150104,transport across blood-brain barrier;GO:0042760,very long-chain fatty acid catabolic process	hsa:10999,path:hsa03320,PPAR signaling pathway;hsa:10999,path:hsa04975,Fat digestion and absorption;hsa:10999,path:hsa04931,Insulin resistance
SRRM2_HUMAN	Q9UQ35	SRRM2	Serine/arginine repetitive matrix protein 2	0.659885768	0.057001092	0.289125733	0.610064456	0.35844343	0.4495950945	0.35844343	0.4495950945	0.797258320619866	0.483278	0	1.25429860578	0.483388	0	GO:0015030,Cajal body;GO:0071013,catalytic step 2 spliceosome;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0071007,U2-type catalytic step 2 spliceosome;GO:0071005,U2-type precatalytic spliceosome	GO:0070742,C2H2 zinc finger domain binding;GO:0003729,mRNA binding;GO:0047485,protein N-terminus binding;GO:0003723,RNA binding	GO:0000398,mRNA splicing, via spliceosome	
LPPRC_HUMAN	P42704	LRPPRC	Leucine-rich PPR motif-containing protein, mitochondrial	4.442186402	4.160007694	7.237355601	4.705710685	4.301097048	5.971533143	4.301097048	5.971533143	0.720266796650349	0.421863	0	1.38837442549146	0.422041	0	GO:0000794,condensed nuclear chromosome;GO:0005856,cytoskeleton;GO:0016020,membrane;GO:0005874,microtubule;GO:0042645,mitochondrial nucleoid;GO:0005739,mitochondrion;GO:0005637,nuclear inner membrane;GO:0005640,nuclear outer membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:1990904,ribonucleoprotein complex	GO:0048487,beta-tubulin binding;GO:0008017,microtubule binding;GO:0003723,RNA binding;GO:0003697,single-stranded DNA binding;GO:0031625,ubiquitin protein ligase binding	GO:0047497,mitochondrion transport along microtubule;GO:0051028,mRNA transport;GO:0000961,negative regulation of mitochondrial RNA catabolic process;GO:0070129,regulation of mitochondrial translation	
VDAC1_HUMAN	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	12.46621426	16.59136528	13.48274907	5.8581075	14.52878977	9.670428285	14.52878977	9.670428285	1.50239362123557	0.304695	0	0.665604529908481	0.304252	0	GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0045121,membrane raft;GO:0031966,mitochondrial membrane;GO:0042645,mitochondrial nucleoid;GO:0005741,mitochondrial outer membrane;GO:0005757,mitochondrial permeability transition pore complex;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0046930,pore complex;GO:0008021,synaptic vesicle	GO:0097001,ceramide binding;GO:0015485,cholesterol binding;GO:0042802,identical protein binding;GO:0044325,ion channel binding;GO:0031210,phosphatidylcholine binding;GO:0015288,porin activity;GO:0019901,protein kinase binding;GO:0044877,protein-containing complex binding;GO:0008308,voltage-gated anion channel activity	GO:0006820,anion transport;GO:0006915,apoptotic process;GO:0001662,behavioral fear response;GO:0030855,epithelial cell differentiation;GO:0007612,learning;GO:0016236,macroautophagy;GO:0006851,mitochondrial calcium ion transmembrane transport;GO:0043066,negative regulation of apoptotic process;GO:0110099,negative regulation of calcium import into the mitochondrion;GO:2000378,negative regulation of reactive oxygen species metabolic process;GO:0007270,neuron-neuron synaptic transmission;GO:1901526,positive regulation of mitophagy;GO:0006090,pyruvate metabolic process;GO:1903146,regulation of autophagy of mitochondrion;GO:0016032,viral process	hsa:7416,path:hsa04020,Calcium signaling pathway;hsa:7416,path:hsa04022,cGMP-PKG signaling pathway;hsa:7416,path:hsa04217,Necroptosis;hsa:7416,path:hsa04218,Cellular senescence;hsa:7416,path:hsa04621,NOD-like receptor signaling pathway;hsa:7416,path:hsa04979,Cholesterol metabolism;hsa:7416,path:hsa05012,Parkinson disease;hsa:7416,path:hsa05016,Huntington disease;hsa:7416,path:hsa05131,Shigellosis;hsa:7416,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:7416,path:hsa05164,Influenza A
HNRH1_HUMAN	P31943	HNRNPH1	Heterogeneous nuclear ribonucleoprotein H	9.721307129	10.27634199	13.40108038	10.47233869	9.9988245595	11.936709535	9.9988245595	11.936709535	0.837653335718871	0.492606	0	1.19381127891266	0.492540	0	GO:0071013,catalytic step 2 spliceosome;GO:0005829,cytosol;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex	GO:0042802,identical protein binding;GO:0008266,poly(U) RNA binding;GO:0003723,RNA binding;GO:0003676,nucleic acid binding	GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0000398,mRNA splicing, via spliceosome;GO:0043484,regulation of RNA splicing;GO:0016070,RNA metabolic process;GO:0006396,RNA processing	
TCPQ_HUMAN	P50990	CCT8	T-complex protein 1 subunit theta	20.74296206	15.07266473	18.36162193	16.03721008	17.907813395	17.199416005	17.907813395	17.199416005	1.04118729320775	0.420010	0	0.960441993984716	0.419785	0	GO:0035578,azurophil granule lumen;GO:0044297,cell body;GO:0005813,centrosome;GO:0005832,chaperonin-containing T-complex;GO:0005929,cilium;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0045111,intermediate filament cytoskeleton;GO:0005874,microtubule;GO:0005654,nucleoplasm;GO:0034774,secretory granule lumen;GO:0002199,zona pellucida receptor complex	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0045296,cadherin binding;GO:0044183,protein folding chaperone;GO:0051082,unfolded protein binding	GO:0007339,binding of sperm to zona pellucida;GO:0043312,neutrophil degranulation;GO:0046931,pore complex assembly;GO:1904851,positive regulation of establishment of protein localization to telomere;GO:1904871,positive regulation of protein localization to Cajal body;GO:1904874,positive regulation of telomerase RNA localization to Cajal body;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:0006457,protein folding;GO:0050821,protein stabilization;GO:1901998,toxin transport	
DDAH1_HUMAN	O94760	DDAH1	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0.077106013	0.142271025	0.303834975	0.279360626	0.109688519	0.2915978005	0.109688519	0.2915978005	0.376163739273472	0.117052	0	2.65841678927218	0.117366	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0016597,amino acid binding;GO:0003824,catalytic activity;GO:0016403,dimethylargininase activity;GO:0046872,metal ion binding	GO:0006527,arginine catabolic process;GO:0006525,arginine metabolic process;GO:0000052,citrulline metabolic process;GO:0008285,negative regulation of cell population proliferation;GO:1900038,negative regulation of cellular response to hypoxia;GO:0043116,negative regulation of vascular permeability;GO:0007263,nitric oxide mediated signal transduction;GO:0045766,positive regulation of angiogenesis;GO:0045429,positive regulation of nitric oxide biosynthetic process;GO:0050999,regulation of nitric-oxide synthase activity;GO:0003073,regulation of systemic arterial blood pressure	
PRDX3_HUMAN	P30048	PRDX3	Thioredoxin-dependent peroxide reductase, mitochondrial	5.170801489	57.82637597	4.467430417	2.582532485	31.4985887295	3.524981451	31.4985887295	3.524981451	8.93581687374956	0.022017	1	0.111909186829652	0.021775	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005769,early endosome;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0032991,protein-containing complex	GO:0008785,alkyl hydroperoxide reductase activity;GO:0043027,cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0042802,identical protein binding;GO:0019900,kinase binding;GO:0008022,protein C-terminus binding;GO:0019901,protein kinase binding;GO:0008379,thioredoxin peroxidase activity	GO:0045454,cell redox homeostasis;GO:0034599,cellular response to oxidative stress;GO:0034614,cellular response to reactive oxygen species;GO:0042744,hydrogen peroxide catabolic process;GO:0001893,maternal placenta development;GO:0007005,mitochondrion organization;GO:0030099,myeloid cell differentiation;GO:0043066,negative regulation of apoptotic process;GO:0033673,negative regulation of kinase activity;GO:0018171,peptidyl-cysteine oxidation;GO:0008284,positive regulation of cell population proliferation;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0051881,regulation of mitochondrial membrane potential;GO:0042542,response to hydrogen peroxide;GO:0032496,response to lipopolysaccharide;GO:0006979,response to oxidative stress	
NEK9_HUMAN	Q8TD19	NEK9	Serine/threonine-protein kinase Nek9	0.614495529	0.513414523	1.001528601	1.045765779	0.563955026	1.02364719	0.563955026	1.02364719	0.550927147076914	0.272019	0	1.8151220271242	0.272325	0	GO:0005829,cytosol;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0046872,metal ion binding;GO:0019901,protein kinase binding;GO:0106310,protein serine kinase activity;GO:0106311,protein threonine kinase activity;GO:0004672,protein kinase activity	GO:0051301,cell division;GO:0007077,mitotic nuclear envelope disassembly;GO:0007052,mitotic spindle organization	
AP2A1_HUMAN	O95782	AP2A1	AP-2 complex subunit alpha-1	2.696230443	4.462622826	4.16664865	4.646791181	3.5794266345	4.4067199155	3.5794266345	4.4067199155	0.812265517921819	0.494643	0	1.23112452509187	0.494740	0	GO:0030122,AP-2 adaptor complex;GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0030130,clathrin coat of trans-Golgi network vesicle;GO:0045334,clathrin-coated endocytic vesicle;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0005829,cytosol;GO:0030666,endocytic vesicle membrane;GO:0036020,endolysosome membrane;GO:0032433,filopodium tip;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0140312,cargo adaptor activity;GO:0035615,clathrin adaptor activity;GO:0050750,low-density lipoprotein particle receptor binding;GO:0008022,protein C-terminus binding;GO:0019901,protein kinase binding;GO:0044877,protein-containing complex binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0072583,clathrin-dependent endocytosis;GO:0006897,endocytosis;GO:0048013,ephrin receptor signaling pathway;GO:0006895,Golgi to endosome transport;GO:0006886,intracellular protein transport;GO:0034383,low-density lipoprotein particle clearance;GO:0032802,low-density lipoprotein particle receptor catabolic process;GO:0061024,membrane organization;GO:1900126,negative regulation of hyaluronan biosynthetic process;GO:0010976,positive regulation of neuron projection development;GO:0048260,positive regulation of receptor-mediated endocytosis;GO:0006898,receptor-mediated endocytosis;GO:0050690,regulation of defense response to virus by virus;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:160,path:hsa04144,Endocytosis;hsa:160,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:160,path:hsa04721,Synaptic vesicle cycle;hsa:160,path:hsa05016,Huntington disease
MCM2_HUMAN	P49736	MCM2	DNA replication licensing factor MCM2	0.763771158	0.112867583	0.583322703	1.023644716	0.4383193705	0.8034837095	0.4383193705	0.8034837095	0.545523655697714	0.267042	0	1.83310107555468	0.267352	0	GO:0000785,chromatin;GO:0000781,chromosome, telomeric region;GO:0071162,CMG complex;GO:0005737,cytoplasm;GO:0042555,MCM complex;GO:0005664,nuclear origin of replication recognition complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005694,chromosome	GO:0005524,ATP binding;GO:0003677,DNA binding;GO:0003678,DNA helicase activity;GO:0003688,DNA replication origin binding;GO:0019899,enzyme binding;GO:0042393,histone binding;GO:0016787,hydrolase activity;GO:0046872,metal ion binding;GO:0003697,single-stranded DNA binding	GO:0006915,apoptotic process;GO:0071353,cellular response to interleukin-4;GO:0090102,cochlea development;GO:0006260,DNA replication;GO:0006270,DNA replication initiation;GO:0006268,DNA unwinding involved in DNA replication;GO:0000727,double-strand break repair via break-induced replication;GO:1902975,mitotic DNA replication initiation;GO:1905775,negative regulation of DNA helicase activity;GO:0006334,nucleosome assembly;GO:0036388,pre-replicative complex assembly;GO:0006267,pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0007049,cell cycle	hsa:4171,path:hsa03030,DNA replication;hsa:4171,path:hsa04110,Cell cycle
CBX1_HUMAN	P83916	CBX1	Chromobox protein homolog 1	0.176382547	0.692437847	0.07273626	2.55E-05	0.434410197	0.03638088	0.434410197	0.03638088	11.9406181763608	0.011970	1	0.0837477578823961	0.011809	-1	GO:0000785,chromatin;GO:0010369,chromocenter;GO:0000775,chromosome, centromeric region;GO:0000781,chromosome, telomeric region;GO:0001939,female pronucleus;GO:0000792,heterochromatin;GO:0001940,male pronucleus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005721,pericentric heterochromatin;GO:0090734,site of DNA damage;GO:0005819,spindle	GO:0003682,chromatin binding;GO:0019899,enzyme binding;GO:1990226,histone methyltransferase binding;GO:0042802,identical protein binding	GO:0006974,cellular response to DNA damage stimulus;GO:0045892,negative regulation of transcription, DNA-templated;GO:0019058,viral life cycle	
TMOD3_HUMAN	Q9NYL9	TMOD3	Tropomodulin-3	1.056118515	0.594537122	1.826231014	1.227597902	0.8253278185	1.526914458	0.8253278185	1.526914458	0.540520010257182	0.262433	0	1.85007026756363	0.262745	0	GO:0005912,adherens junction;GO:0005856,cytoskeleton;GO:0030016,myofibril;GO:0005865,striated muscle thin filament	GO:0003779,actin binding;GO:0098641,cadherin binding involved in cell-cell adhesion;GO:0005523,tropomyosin binding	GO:0007015,actin filament organization;GO:0048821,erythrocyte development;GO:0006936,muscle contraction;GO:0030239,myofibril assembly;GO:0051694,pointed-end actin filament capping;GO:1901992,positive regulation of mitotic cell cycle phase transition;GO:0030036,actin cytoskeleton organization	
SYNM_HUMAN	Q96I59	NARS2	Probable asparagine--tRNA ligase, mitochondrial	0.126530312	0.144164714	0.268772387	0.146091012	0.135347513	0.2074316995	0.135347513	0.2074316995	0.652491944703948	0.363863	0	1.53258597001335	0.364099	0	GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0004816,asparagine-tRNA ligase activity;GO:0005524,ATP binding;GO:0003676,nucleic acid binding;GO:0004812,aminoacyl-tRNA ligase activity	GO:0006421,asparaginyl-tRNA aminoacylation;GO:0006418,tRNA aminoacylation for protein translation	hsa:79731,path:hsa00970,Aminoacyl-tRNA biosynthesis
CLIC1_HUMAN	O00299	CLIC1	Chloride intracellular channel protein 1	22.97014329	25.88345281	18.94524883	14.17660325	24.42679805	16.56092604	24.42679805	16.56092604	1.47496571091504	0.310154	0	0.677981862628942	0.309719	0	GO:0072562,blood microparticle;GO:0005903,brush border;GO:0034707,chloride channel complex;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0031982,vesicle	GO:0045296,cadherin binding;GO:0005254,chloride channel activity;GO:0005244,voltage-gated ion channel activity	GO:0006821,chloride transport;GO:0006749,glutathione metabolic process;GO:0070527,platelet aggregation;GO:0045669,positive regulation of osteoblast differentiation;GO:0051726,regulation of cell cycle;GO:0034765,regulation of ion transmembrane transport;GO:0051881,regulation of mitochondrial membrane potential;GO:0007165,signal transduction	
GEMI5_HUMAN	Q8TEQ6	GEMIN5	Gem-associated protein 5	0.084713427	0.051799765	0.12028996	0.484904	0.068256596	0.30259698	0.068256596	0.30259698	0.225569323262909	0.024340	-1	4.43322693677839	0.024483	1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0097504,Gemini of coiled bodies;GO:0016020,membrane;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0032797,SMN complex;GO:0034718,SMN-Gemin2 complex;GO:0034719,SMN-Sm protein complex	GO:0003730,mRNA 3'-UTR binding;GO:0043022,ribosome binding;GO:0000340,RNA 7-methylguanosine cap binding;GO:0003723,RNA binding;GO:0017069,snRNA binding;GO:0030619,U1 snRNA binding;GO:0030621,U4 snRNA binding;GO:0030622,U4atac snRNA binding	GO:0051170,import into nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0065003,protein-containing complex assembly;GO:0006417,regulation of translation;GO:0000387,spliceosomal snRNP assembly;GO:0006412,translation	hsa:25929,path:hsa03013,RNA transport
PPGB_HUMAN	P10619	CTSA	Lysosomal protective protein	1.020891854	2.384877538	0.305309012	0.127355808	1.702884696	0.21633241	1.702884696	0.21633241	7.87161154447454	0.028267	1	0.127038789242839	0.027984	-1	GO:0035578,azurophil granule lumen;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0043231,intracellular membrane-bounded organelle;GO:0043202,lysosomal lumen;GO:0005764,lysosome;GO:0016020,membrane;GO:0005765,lysosomal membrane	GO:0004180,carboxypeptidase activity;GO:0008047,enzyme activator activity;GO:0004185,serine-type carboxypeptidase activity	GO:0006687,glycosphingolipid metabolic process;GO:0006886,intracellular protein transport;GO:1904715,negative regulation of chaperone-mediated autophagy;GO:0043312,neutrophil degranulation;GO:0006508,proteolysis;GO:1904714,regulation of chaperone-mediated autophagy;GO:0031647,regulation of protein stability	hsa:5476,path:hsa04142,Lysosome;hsa:5476,path:hsa04614,Renin-angiotensin system
TM230_HUMAN	Q96A57	TMEM230	Transmembrane protein 230	0.327098291	0.413824141	0.054553987	2.55E-05	0.370461216	0.0272897435	0.370461216	0.0272897435	13.5751080254748	0.008985	1	0.0736642388497694	0.008855	-1	GO:0005776,autophagosome;GO:0005769,early endosome;GO:0005783,endoplasmic reticulum;GO:0016021,integral component of membrane;GO:0005770,late endosome;GO:0055037,recycling endosome;GO:0008021,synaptic vesicle;GO:0005802,trans-Golgi network		GO:0048489,synaptic vesicle transport	
F162A_HUMAN	Q96A26	FAM162A	Protein FAM162A	1.496698712	1.665402256	0.072042123	0.099557448	1.581050484	0.0857997855	1.581050484	0.0857997855	18.4272078862015	0.004348	1	0.0542675811862311	0.004272	-1	GO:0005829,cytosol;GO:0016021,integral component of membrane;GO:0031966,mitochondrial membrane;GO:0005739,mitochondrion		GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0071456,cellular response to hypoxia;GO:0051402,neuron apoptotic process;GO:0043065,positive regulation of apoptotic process;GO:0090200,positive regulation of release of cytochrome c from mitochondria	
PARP1_HUMAN	P09874	PARP1	Poly [ADP-ribose] polymerase 1	6.197096102	4.152528374	7.818076954	6.208932313	5.174812238	7.0135046335	5.174812238	7.0135046335	0.73783543441071	0.436322	0	1.35531577010621	0.436484	0	GO:0000781,chromosome, telomeric region;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0016604,nuclear body;GO:0005635,nuclear envelope;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0032993,protein-DNA complex;GO:0090734,site of DNA damage;GO:0035861,site of double-strand break;GO:0005667,transcription regulator complex	GO:0003677,DNA binding;GO:0019899,enzyme binding;GO:0030331,estrogen receptor binding;GO:0042826,histone deacetylase binding;GO:0042802,identical protein binding;GO:0051287,NAD binding;GO:0140294,NAD DNA ADP-ribosyltransferase activity;GO:0003950,NAD+ ADP-ribosyltransferase activity;GO:1990404,protein ADP-ribosylase activity;GO:0019901,protein kinase binding;GO:0047485,protein N-terminus binding;GO:0070412,R-SMAD binding;GO:0003723,RNA binding;GO:0008134,transcription factor binding;GO:0008270,zinc ion binding	GO:0006915,apoptotic process;GO:1990966,ATP generation from poly-ADP-D-ribose;GO:0006287,base-excision repair, gap-filling;GO:1904646,cellular response to amyloid-beta;GO:0006974,cellular response to DNA damage stimulus;GO:0032869,cellular response to insulin stimulus;GO:0034599,cellular response to oxidative stress;GO:0034644,cellular response to UV;GO:0071294,cellular response to zinc ion;GO:0030592,DNA ADP-ribosylation;GO:0042769,DNA damage response, detection of DNA damage;GO:0006281,DNA repair;GO:0006302,double-strand break repair;GO:0000724,double-strand break repair via homologous recombination;GO:0070911,global genome nucleotide-excision repair;GO:0030225,macrophage differentiation;GO:0032042,mitochondrial DNA metabolic process;GO:0043504,mitochondrial DNA repair;GO:0007005,mitochondrion organization;GO:2001170,negative regulation of ATP biosynthetic process;GO:1904357,negative regulation of telomere maintenance via telomere lengthening;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0000715,nucleotide-excision repair, DNA damage recognition;GO:0000717,nucleotide-excision repair, DNA duplex unwinding;GO:0033683,nucleotide-excision repair, DNA incision;GO:0006295,nucleotide-excision repair, DNA incision, 3'-to lesion;GO:0006296,nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006294,nucleotide-excision repair, preincision complex assembly;GO:0006293,nucleotide-excision repair, preincision complex stabilization;GO:0018424,peptidyl-glutamic acid poly-ADP-ribosylation;GO:0018312,peptidyl-serine ADP-ribosylation;GO:0010613,positive regulation of cardiac muscle hypertrophy;GO:1905168,positive regulation of double-strand break repair via homologous recombination;GO:0033148,positive regulation of intracellular estrogen receptor signaling pathway;GO:0051901,positive regulation of mitochondrial depolarization;GO:1904762,positive regulation of myofibroblast differentiation;GO:1901216,positive regulation of neuron death;GO:1900182,positive regulation of protein localization to nucleus;GO:1903518,positive regulation of single strand break repair;GO:0060391,positive regulation of SMAD protein signal transduction;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:2000679,positive regulation of transcription regulatory region DNA binding;GO:0006471,protein ADP-ribosylation;GO:0070213,protein auto-ADP-ribosylation;GO:0016540,protein autoprocessing;GO:0036211,protein modification process;GO:0070212,protein poly-ADP-ribosylation;GO:0050790,regulation of catalytic activity;GO:1903827,regulation of cellular protein localization;GO:0044030,regulation of DNA methylation;GO:1903376,regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway;GO:0010990,regulation of SMAD protein complex assembly;GO:1904044,response to aldosterone;GO:0010332,response to gamma radiation;GO:0023019,signal transduction involved in regulation of gene expression;GO:0000723,telomere maintenance;GO:0006366,transcription by RNA polymerase II;GO:0007179,transforming growth factor beta receptor signaling pathway	hsa:142,path:hsa03410,Base excision repair;hsa:142,path:hsa04064,NF-kappa B signaling pathway;hsa:142,path:hsa04210,Apoptosis;hsa:142,path:hsa04217,Necroptosis
SCAM2_HUMAN	O15127	SCAMP2	Secretory carrier-associated membrane protein 2	0.822063467	0.91922009	1.338298147	1.498088622	0.8706417785	1.4181933845	0.8706417785	1.4181933845	0.613909067702325	0.329498	0	1.62890573312868	0.329764	0	GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0055038,recycling endosome membrane;GO:0032588,trans-Golgi network membrane;GO:0030133,transport vesicle		GO:0006892,post-Golgi vesicle-mediated transport;GO:0015031,protein transport	
PSB2_HUMAN	P49721	PSMB2	Proteasome subunit beta type-2	4.63549744	5.854728924	0.730874715	0.33160833	5.245113182	0.5312415225	5.245113182	0.5312415225	9.87331177976586	0.017958	1	0.101283138049927	0.017747	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000502,proteasome complex;GO:0005839,proteasome core complex;GO:0019774,proteasome core complex, beta-subunit complex	GO:0004175,endopeptidase activity;GO:0004298,threonine-type endopeptidase activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0014070,response to organic cyclic compound;GO:0010243,response to organonitrogen compound;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0051603,proteolysis involved in cellular protein catabolic process	hsa:5690,path:hsa03050,Proteasome
ANO6_HUMAN	Q4KMQ2	ANO6	Anoctamin-6	0.186786983	0.292337199	0.406589729	4.609723337	0.239562091	2.508156533	0.239562091	2.508156533	0.0955132137281162	0.000511	-1	10.4697555549388	0.000518	1	GO:0009986,cell surface;GO:0034707,chloride channel complex;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0035579,specific granule membrane;GO:0070821,tertiary granule membrane	GO:0005227,calcium activated cation channel activity;GO:0005254,chloride channel activity;GO:0005229,intracellular calcium activated chloride channel activity;GO:0046872,metal ion binding;GO:0017128,phospholipid scramblase activity;GO:0046983,protein dimerization activity;GO:0005247,voltage-gated chloride channel activity;GO:0005244,voltage-gated ion channel activity	GO:0002543,activation of blood coagulation via clotting cascade;GO:0032060,bleb assembly;GO:0007596,blood coagulation;GO:0061590,calcium activated phosphatidylcholine scrambling;GO:0061589,calcium activated phosphatidylserine scrambling;GO:0070588,calcium ion transmembrane transport;GO:0006812,cation transport;GO:1902476,chloride transmembrane transport;GO:0006821,chloride transport;GO:0002407,dendritic cell chemotaxis;GO:0034220,ion transmembrane transport;GO:0045794,negative regulation of cell volume;GO:0043312,neutrophil degranulation;GO:0097045,phosphatidylserine exposure on blood platelet;GO:0017121,plasma membrane phospholipid scrambling;GO:0046931,pore complex assembly;GO:0043065,positive regulation of apoptotic process;GO:0030501,positive regulation of bone mineralization;GO:2000353,positive regulation of endothelial cell apoptotic process;GO:0034767,positive regulation of ion transmembrane transport;GO:0090026,positive regulation of monocyte chemotaxis;GO:0060100,positive regulation of phagocytosis, engulfment;GO:1903766,positive regulation of potassium ion export across plasma membrane;GO:0035590,purinergic nucleotide receptor signaling pathway;GO:0035725,sodium ion transmembrane transport;GO:0055085,transmembrane transport	
CSPG2_HUMAN	P13611	VCAN	Versican core protein	2.610646487	2.715525927	1.957804386	2.327785336	2.663086207	2.142794861	2.663086207	2.142794861	1.24280968536446	0.362770	0	0.804628425233701	0.362428	0	GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005796,Golgi lumen;GO:0033165,interphotoreceptor matrix;GO:0043202,lysosomal lumen;GO:0016020,membrane;GO:0001750,photoreceptor outer segment	GO:0005509,calcium ion binding;GO:0030246,carbohydrate binding;GO:0030021,extracellular matrix structural constituent conferring compression resistance;GO:0005539,glycosaminoglycan binding;GO:0005540,hyaluronic acid binding	GO:0007155,cell adhesion;GO:0008037,cell recognition;GO:0044267,cellular protein metabolic process;GO:0007417,central nervous system development;GO:0030206,chondroitin sulfate biosynthetic process;GO:0030207,chondroitin sulfate catabolic process;GO:0030208,dermatan sulfate biosynthetic process;GO:0030198,extracellular matrix organization;GO:0008347,glial cell migration;GO:0007275,multicellular organism development;GO:0001649,osteoblast differentiation;GO:0043687,post-translational protein modification;GO:0001501,skeletal system development	hsa:1462,path:hsa04514,Cell adhesion molecules (CAMs)
VPS18_HUMAN	Q9P253	VPS18	Vacuolar protein sorting-associated protein 18 homolog	0.342653898	0.429358886	0.503651992	0.324677564	0.386006392	0.414164778	0.386006392	0.414164778	0.932011635233743	0.456799	0	1.07294797854021	0.456653	0	GO:0005884,actin filament;GO:0030123,AP-3 adaptor complex;GO:0005776,autophagosome;GO:0030136,clathrin-coated vesicle;GO:0033263,CORVET complex;GO:0005769,early endosome;GO:0005768,endosome;GO:0098978,glutamatergic synapse;GO:0030897,HOPS complex;GO:0005770,late endosome;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0098793,presynapse	GO:0003779,actin binding;GO:0046872,metal ion binding;GO:0030674,protein-macromolecule adaptor activity;GO:0019905,syntaxin binding;GO:0061630,ubiquitin protein ligase activity	GO:0006914,autophagy;GO:0007032,endosome organization;GO:0008333,endosome to lysosome transport;GO:0006886,intracellular protein transport;GO:0007040,lysosome organization;GO:0033147,negative regulation of intracellular estrogen receptor signaling pathway;GO:0016567,protein ubiquitination;GO:0035542,regulation of SNARE complex assembly;GO:2000300,regulation of synaptic vesicle exocytosis;GO:0007033,vacuole organization;GO:0006904,vesicle docking involved in exocytosis;GO:0046718,viral entry into host cell	hsa:57617,path:hsa05132,Salmonella infection
CD9_HUMAN	P21926	CD9	CD9 antigen	4.568854189	7.138971212	2.126150064	3.97436462	5.8539127005	3.050257342	5.8539127005	3.050257342	1.9191537120149	0.236595	0	0.521063004875264	0.236063	0	GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0030666,endocytic vesicle membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:1903561,extracellular vesicle;GO:0005925,focal adhesion;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0031092,platelet alpha granule membrane;GO:0032991,protein-containing complex;GO:0005576,extracellular region;GO:0016021,integral component of membrane;GO:0016324,apical plasma membrane;GO:0009897,external side of plasma membrane	GO:0005178,integrin binding	GO:0007155,cell adhesion;GO:0071404,cellular response to low-density lipoprotein particle stimulus;GO:0007342,fusion of sperm to egg plasma membrane involved in single fertilization;GO:0008347,glial cell migration;GO:0014905,myoblast fusion involved in skeletal muscle regeneration;GO:0051271,negative regulation of cellular component movement;GO:0090331,negative regulation of platelet aggregation;GO:0030913,paranodal junction assembly;GO:0030168,platelet activation;GO:0002576,platelet degranulation;GO:0031623,receptor internalization;GO:0035036,sperm-egg recognition;GO:0007338,single fertilization;GO:0007420,brain development;GO:0008285,negative regulation of cell population proliferation;GO:0014003,oligodendrocyte development;GO:1905521,regulation of macrophage migration;GO:0009414,response to water deprivation	hsa:928,path:hsa04640,Hematopoietic cell lineage
MOES_HUMAN	P26038	MSN	Moesin	50.46136412	45.25281084	75.09916787	130.1602101	47.85708748	102.629688985	47.85708748	102.629688985	0.466308413806015	0.194465	0	2.14450344534423	0.194801	0	GO:0045177,apical part of cell;GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0072562,blood microparticle;GO:0071944,cell periphery;GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0030175,filopodium;GO:0005925,focal adhesion;GO:0005902,microvillus;GO:0031528,microvillus membrane;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0031143,pseudopodium;GO:0001931,uropod;GO:0031982,vesicle	GO:0003779,actin binding;GO:0050839,cell adhesion molecule binding;GO:0003725,double-stranded RNA binding;GO:0019899,enzyme binding;GO:0019901,protein kinase binding;GO:0005102,signaling receptor binding;GO:0005200,structural constituent of cytoskeleton;GO:0008092,cytoskeletal protein binding	GO:0071394,cellular response to testosterone stimulus;GO:0061028,establishment of endothelial barrier;GO:0045198,establishment of epithelial cell apical/basal polarity;GO:0022612,gland morphogenesis;GO:0001771,immunological synapse formation;GO:0035722,interleukin-12-mediated signaling pathway;GO:0007159,leukocyte cell-cell adhesion;GO:0050900,leukocyte migration;GO:0022614,membrane to membrane docking;GO:1903364,positive regulation of cellular protein catabolic process;GO:2000643,positive regulation of early endosome to late endosome transport;GO:0010628,positive regulation of gene expression;GO:0071803,positive regulation of podosome assembly;GO:1902966,positive regulation of protein localization to early endosome;GO:0008360,regulation of cell shape;GO:0008361,regulation of cell size;GO:2000401,regulation of lymphocyte migration;GO:1902115,regulation of organelle assembly;GO:0070489,T cell aggregation;GO:0072678,T cell migration;GO:0042098,T cell proliferation;GO:0016032,viral process	hsa:4478,path:hsa04530,Tight junction;hsa:4478,path:hsa04810,Regulation of actin cytoskeleton;hsa:4478,path:hsa04670,Leukocyte transendothelial migration;hsa:4478,path:hsa05205,Proteoglycans in cancer;hsa:4478,path:hsa05162,Measles
SEPT8_HUMAN	Q92599	SEPTIN8	Septin-8	0.175533863	0.100884158	0.039044456	0.185736715	0.1382090105	0.1123905855	0.1382090105	0.1123905855	1.22972053117385	0.366122	0	0.813192895987053	0.365787	0	GO:0030424,axon;GO:0032153,cell division site;GO:0015630,microtubule cytoskeleton;GO:0098793,presynapse;GO:0031105,septin complex;GO:0005940,septin ring;GO:0030672,synaptic vesicle membrane;GO:0005856,cytoskeleton	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0060090,molecular adaptor activity	GO:0034613,cellular protein localization;GO:0061640,cytoskeleton-dependent cytokinesis;GO:0033157,regulation of intracellular protein transport;GO:0031647,regulation of protein stability;GO:0035542,regulation of SNARE complex assembly	hsa:23176,path:hsa05131,Shigellosis;hsa:23176,path:hsa05100,Bacterial invasion of epithelial cells
RENT1_HUMAN	Q92900	UPF1	Regulator of nonsense transcripts 1	2.949753465	2.843140294	5.248486353	4.26591242	2.8964468795	4.7571993865	2.8964468795	4.7571993865	0.60885547234357	0.324939	0	1.6424259047075	0.325209	0	GO:0000785,chromatin;GO:0000781,chromosome, telomeric region;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0035145,exon-exon junction complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body;GO:0044530,supraspliceosomal complex	GO:0005524,ATP binding;GO:0003682,chromatin binding;GO:0004386,helicase activity;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0042162,telomeric DNA binding;GO:0008270,zinc ion binding	GO:0061158,3'-UTR-mediated mRNA destabilization;GO:0044770,cell cycle phase transition;GO:0071347,cellular response to interleukin-1;GO:0071222,cellular response to lipopolysaccharide;GO:0006281,DNA repair;GO:0006260,DNA replication;GO:0009048,dosage compensation by inactivation of X chromosome;GO:0071044,histone mRNA catabolic process;GO:0006406,mRNA export from nucleus;GO:0000956,nuclear-transcribed mRNA catabolic process;GO:0000294,nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0061014,positive regulation of mRNA catabolic process;GO:0032204,regulation of telomere maintenance;GO:0006449,regulation of translational termination;GO:0032201,telomere maintenance via semi-conservative replication;GO:0016032,viral process	hsa:5976,path:hsa03013,RNA transport;hsa:5976,path:hsa03015,mRNA surveillance pathway
EVPL_HUMAN	Q92817	EVPL	Envoplakin	4.503579361	3.797535084	4.686536495	10.55534831	4.1505572225	7.6209424025	4.1505572225	7.6209424025	0.544625192435313	0.266215	0	1.83612512584748	0.266525	0	GO:0001533,cornified envelope;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030057,desmosome;GO:0070062,extracellular exosome;GO:0045111,intermediate filament cytoskeleton;GO:0016020,membrane;GO:0005856,cytoskeleton	GO:0045296,cadherin binding;GO:0019215,intermediate filament binding;GO:0005198,structural molecule activity	GO:0070268,cornification;GO:0008544,epidermis development;GO:0045104,intermediate filament cytoskeleton organization;GO:0030216,keratinocyte differentiation;GO:0018149,peptide cross-linking;GO:0042060,wound healing	
MK01_HUMAN	P28482	MAPK1	Mitogen-activated protein kinase 1	2.762398471	4.151840756	5.14921375	5.234479129	3.4571196135	5.1918464395	3.4571196135	5.1918464395	0.665874781503156	0.375575	0	1.50178386053694	0.375799	0	GO:0030424,axon;GO:0035578,azurophil granule lumen;GO:0005901,caveola;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0032839,dendrite cytoplasm;GO:0005769,early endosome;GO:0005788,endoplasmic reticulum lumen;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0005770,late endosome;GO:0005815,microtubule organizing center;GO:0005739,mitochondrion;GO:0072686,mitotic spindle;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0043204,perikaryon;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0032991,protein-containing complex;GO:0031143,pseudopodium	GO:0005524,ATP binding;GO:0003690,double-stranded DNA binding;GO:0042802,identical protein binding;GO:0004707,MAP kinase activity;GO:0004708,MAP kinase kinase activity;GO:0031435,mitogen-activated protein kinase kinase kinase binding;GO:0019902,phosphatase binding;GO:0001784,phosphotyrosine residue binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0008353,RNA polymerase II CTD heptapeptide repeat kinase activity;GO:0008134,transcription factor binding	GO:0000187,activation of MAPK activity;GO:0000186,activation of MAPKK activity;GO:0007568,aging;GO:0006915,apoptotic process;GO:0007411,axon guidance;GO:0050853,B cell receptor signaling pathway;GO:0060020,Bergmann glial cell differentiation;GO:0061308,cardiac neural crest cell development involved in heart development;GO:0072584,caveolin-mediated endocytosis;GO:0007049,cell cycle;GO:0007166,cell surface receptor signaling pathway;GO:0034198,cellular response to amino acid starvation;GO:0071276,cellular response to cadmium ion;GO:0006974,cellular response to DNA damage stimulus;GO:1903351,cellular response to dopamine;GO:0097011,cellular response to granulocyte macrophage colony-stimulating factor stimulus;GO:0034614,cellular response to reactive oxygen species;GO:0071356,cellular response to tumor necrosis factor;GO:0007268,chemical synaptic transmission;GO:0006935,chemotaxis;GO:0019858,cytosine metabolic process;GO:0046697,decidualization;GO:0015966,diadenosine tetraphosphate biosynthetic process;GO:0038127,ERBB signaling pathway;GO:0070371,ERK1 and ERK2 cascade;GO:0060324,face development;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0035556,intracellular signal transduction;GO:0060716,labyrinthine layer blood vessel development;GO:0007611,learning or memory;GO:0031663,lipopolysaccharide-mediated signaling pathway;GO:0060291,long-term synaptic potentiation;GO:0060425,lung morphogenesis;GO:0033598,mammary gland epithelial cell proliferation;GO:0000165,MAPK cascade;GO:0033668,negative regulation by symbiont of host apoptotic process;GO:0045596,negative regulation of cell differentiation;GO:0043312,neutrophil degranulation;GO:0042473,outer ear morphogenesis;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:0030168,platelet activation;GO:0060045,positive regulation of cardiac muscle cell proliferation;GO:0010628,positive regulation of gene expression;GO:0010759,positive regulation of macrophage chemotaxis;GO:0120041,positive regulation of macrophage proliferation;GO:0010800,positive regulation of peptidyl-threonine phosphorylation;GO:0042307,positive regulation of protein import into nucleus;GO:0051973,positive regulation of telomerase activity;GO:1904355,positive regulation of telomere capping;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:0045893,positive regulation of transcription, DNA-templated;GO:0045727,positive regulation of translation;GO:0006468,protein phosphorylation;GO:0030641,regulation of cellular pH;GO:1900034,regulation of cellular response to heat;GO:0051493,regulation of cytoskeleton organization;GO:0051090,regulation of DNA-binding transcription factor activity;GO:2000641,regulation of early endosome to late endosome transport;GO:0090170,regulation of Golgi inheritance;GO:0030278,regulation of ossification;GO:0014066,regulation of phosphatidylinositol 3-kinase signaling;GO:0031647,regulation of protein stability;GO:0032872,regulation of stress-activated MAPK cascade;GO:0070849,response to epidermal growth factor;GO:0043627,response to estrogen;GO:0043330,response to exogenous dsRNA;GO:0035094,response to nicotine;GO:0009636,response to toxic substance;GO:0019233,sensory perception of pain;GO:0007165,signal transduction;GO:0051403,stress-activated MAPK cascade;GO:0050852,T cell receptor signaling pathway;GO:0048538,thymus development;GO:0030878,thyroid gland development;GO:0060440,trachea formation;GO:0016032,viral process	hsa:5594,path:hsa04014,Ras signaling pathway;hsa:5594,path:hsa04015,Rap1 signaling pathway;hsa:5594,path:hsa04010,MAPK signaling pathway;hsa:5594,path:hsa04012,ErbB signaling pathway;hsa:5594,path:hsa04350,TGF-beta signaling pathway;hsa:5594,path:hsa04370,VEGF signaling pathway;hsa:5594,path:hsa04371,Apelin signaling pathway;hsa:5594,path:hsa04668,TNF signaling pathway;hsa:5594,path:hsa04066,HIF-1 signaling pathway;hsa:5594,path:hsa04068,FoxO signaling pathway;hsa:5594,path:hsa04072,Phospholipase D signaling pathway;hsa:5594,path:hsa04071,Sphingolipid signaling pathway;hsa:5594,path:hsa04024,cAMP signaling pathway;hsa:5594,path:hsa04022,cGMP-PKG signaling pathway;hsa:5594,path:hsa04151,PI3K-Akt signaling pathway;hsa:5594,path:hsa04150,mTOR signaling pathway;hsa:5594,path:hsa04140,Autophagy - animal;hsa:5594,path:hsa04114,Oocyte meiosis;hsa:5594,path:hsa04210,Apoptosis;hsa:5594,path:hsa04218,Cellular senescence;hsa:5594,path:hsa04510,Focal adhesion;hsa:5594,path:hsa04520,Adherens junction;hsa:5594,path:hsa04540,Gap junction;hsa:5594,path:hsa04550,Signaling pathways regulating pluripotency of stem cells;hsa:5594,path:hsa04810,Regulation of actin cytoskeleton;hsa:5594,path:hsa04611,Platelet activation;hsa:5594,path:hsa04620,Toll-like receptor signaling pathway;hsa:5594,path:hsa04621,NOD-like receptor signaling pathway;hsa:5594,path:hsa04625,C-type lectin receptor signaling pathway;hsa:5594,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:5594,path:hsa04660,T cell receptor signaling pathway;hsa:5594,path:hsa04658,Th1 and Th2 cell differentiation;hsa:5594,path:hsa04659,Th17 cell differentiation;hsa:5594,path:hsa04657,IL-17 signaling pathway;hsa:5594,path:hsa04662,B cell receptor signaling pathway;hsa:5594,path:hsa04664,Fc epsilon RI signaling pathway;hsa:5594,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:5594,path:hsa04062,Chemokine signaling pathway;hsa:5594,path:hsa04910,Insulin signaling pathway;hsa:5594,path:hsa04929,GnRH secretion;hsa:5594,path:hsa04912,GnRH signaling pathway;hsa:5594,path:hsa04915,Estrogen signaling pathway;hsa:5594,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:5594,path:hsa04917,Prolactin signaling pathway;hsa:5594,path:hsa04921,Oxytocin signaling pathway;hsa:5594,path:hsa04926,Relaxin signaling pathway;hsa:5594,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:5594,path:hsa04919,Thyroid hormone signaling pathway;hsa:5594,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:5594,path:hsa04916,Melanogenesis;hsa:5594,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:5594,path:hsa04270,Vascular smooth muscle contraction;hsa:5594,path:hsa04960,Aldosterone-regulated sodium reabsorption;hsa:5594,path:hsa04724,Glutamatergic synapse;hsa:5594,path:hsa04725,Cholinergic synapse;hsa:5594,path:hsa04726,Serotonergic synapse;hsa:5594,path:hsa04720,Long-term potentiation;hsa:5594,path:hsa04730,Long-term depression;hsa:5594,path:hsa04723,Retrograde endocannabinoid signaling;hsa:5594,path:hsa04722,Neurotrophin signaling pathway;hsa:5594,path:hsa04360,Axon guidance;hsa:5594,path:hsa04380,Osteoclast differentiation;hsa:5594,path:hsa04713,Circadian entrainment;hsa:5594,path:hsa05200,Pathways in cancer;hsa:5594,path:hsa05206,MicroRNAs in cancer;hsa:5594,path:hsa05205,Proteoglycans in cancer;hsa:5594,path:hsa05203,Viral carcinogenesis;hsa:5594,path:hsa05230,Central carbon metabolism in cancer;hsa:5594,path:hsa05231,Choline metabolism in cancer;hsa:5594,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:5594,path:hsa05210,Colorectal cancer;hsa:5594,path:hsa05212,Pancreatic cancer;hsa:5594,path:hsa05225,Hepatocellular carcinoma;hsa:5594,path:hsa05226,Gastric cancer;hsa:5594,path:hsa05214,Glioma;hsa:5594,path:hsa05216,Thyroid cancer;hsa:5594,path:hsa05221,Acute myeloid leukemia;hsa:5594,path:hsa05220,Chronic myeloid leukemia;hsa:5594,path:hsa05218,Melanoma;hsa:5594,path:hsa05211,Renal cell carcinoma;hsa:5594,path:hsa05219,Bladder cancer;hsa:5594,path:hsa05215,Prostate cancer;hsa:5594,path:hsa05213,Endometrial cancer;hsa:5594,path:hsa05224,Breast cancer;hsa:5594,path:hsa05223,Non-small cell lung cancer;hsa:5594,path:hsa05010,Alzheimer disease;hsa:5594,path:hsa05020,Prion diseases;hsa:5594,path:hsa05034,Alcoholism;hsa:5594,path:hsa04930,Type II diabetes mellitus;hsa:5594,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:5594,path:hsa04934,Cushing syndrome;hsa:5594,path:hsa05130,Pathogenic Escherichia coli infection;hsa:5594,path:hsa05132,Salmonella infection;hsa:5594,path:hsa05131,Shigellosis;hsa:5594,path:hsa05135,Yersinia infection;hsa:5594,path:hsa05133,Pertussis;hsa:5594,path:hsa05152,Tuberculosis;hsa:5594,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:5594,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:5594,path:hsa05164,Influenza A;hsa:5594,path:hsa05161,Hepatitis B;hsa:5594,path:hsa05160,Hepatitis C;hsa:5594,path:hsa05163,Human cytomegalovirus infection;hsa:5594,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:5594,path:hsa05165,Human papillomavirus infection;hsa:5594,path:hsa05145,Toxoplasmosis;hsa:5594,path:hsa05140,Leishmaniasis;hsa:5594,path:hsa05142,Chagas disease (American trypanosomiasis);hsa:5594,path:hsa01521,EGFR tyrosine kinase inhibitor resistance;hsa:5594,path:hsa01524,Platinum drug resistance;hsa:5594,path:hsa01522,Endocrine resistance
SEC62_HUMAN	Q99442	SEC62	Translocation protein SEC62	0.440051279	0.410357387	0.464091573	0.330466126	0.425204333	0.3972788495	0.425204333	0.3972788495	1.07029189581863	0.410949	0	0.93432455567192	0.410704	0	GO:0005783,endoplasmic reticulum;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005791,rough endoplasmic reticulum	GO:0038023,signaling receptor activity	GO:0006613,cotranslational protein targeting to membrane;GO:0006620,posttranslational protein targeting to endoplasmic reticulum membrane;GO:0031204,posttranslational protein targeting to membrane, translocation;GO:0015031,protein transport	hsa:7095,path:hsa03060,Protein export;hsa:7095,path:hsa04141,Protein processing in endoplasmic reticulum
UFD1_HUMAN	Q92890	UFD1	Ubiquitin recognition factor in ER-associated degradation protein 1	0.400959838	0.126522333	0.368338451	0.188409613	0.2637410855	0.278374032	0.2637410855	0.278374032	0.947434225833249	0.451317	0	1.05548224112394	0.451159	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0036501,UFD1-NPL4 complex;GO:0034098,VCP-NPL4-UFD1 AAA ATPase complex	GO:0051117,ATPase binding;GO:0036435,K48-linked polyubiquitin modification-dependent protein binding;GO:0031593,polyubiquitin modification-dependent protein binding;GO:0044877,protein-containing complex binding;GO:0005102,signaling receptor binding;GO:0004843,thiol-dependent deubiquitinase	GO:0071712,ER-associated misfolded protein catabolic process;GO:0070987,error-free translesion synthesis;GO:0039536,negative regulation of RIG-I signaling pathway;GO:0032480,negative regulation of type I interferon production;GO:0016579,protein deubiquitination;GO:0030970,retrograde protein transport, ER to cytosol;GO:0001501,skeletal system development;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:7353,path:hsa04141,Protein processing in endoplasmic reticulum
UGPA_HUMAN	Q16851	UGP2	UTP--glucose-1-phosphate uridylyltransferase	5.556085195	7.292722112	7.427172685	7.127035653	6.4244036535	7.277104169	6.4244036535	7.277104169	0.882824198239122	0.474962	0	1.1327283529321	0.474856	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0003983,UTP;GO:0070569,uridylyltransferase activity;GO:0005536,glucose binding;GO:0032557,pyrimidine ribonucleotide binding	GO:0007420,brain development;GO:0005978,glycogen biosynthetic process;GO:0005977,glycogen metabolic process;GO:0006011,UDP-glucose metabolic process;GO:0006065,UDP-glucuronate biosynthetic process;GO:0019255,glucose 1-phosphate metabolic process	hsa:7360,path:hsa00040,Pentose and glucuronate interconversions;hsa:7360,path:hsa00052,Galactose metabolism;hsa:7360,path:hsa00500,Starch and sucrose metabolism;hsa:7360,path:hsa00520,Amino sugar and nucleotide sugar metabolism
ABD12_HUMAN	Q8N2K0	ABHD12	Lysophosphatidylserine lipase ABHD12	0.45341907	0.404806202	0.653270898	0.506079012	0.429112636	0.579674955	0.429112636	0.579674955	0.740264233082142	0.438301	0	1.35086899421904	0.438461	0	GO:0032281,AMPA glutamate receptor complex;GO:0032839,dendrite cytoplasm;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0047372,acylglycerol lipase activity;GO:0004622,lysophospholipase activity;GO:0008474,palmitoyl-(protein) hydrolase activity;GO:0004620,phospholipase activity	GO:0046464,acylglycerol catabolic process;GO:0007628,adult walking behavior;GO:0046475,glycerophospholipid catabolic process;GO:0052651,monoacylglycerol catabolic process;GO:0006660,phosphatidylserine catabolic process;GO:0009395,phospholipid catabolic process;GO:0002084,protein depalmitoylation;GO:0050727,regulation of inflammatory response;GO:0010996,response to auditory stimulus	
GLGB_HUMAN	Q04446	GBE1	1,4-alpha-glucan-branching enzyme	0.522352897	1.291237651	0.693283794	1.447629533	0.906795274	1.0704566635	0.906795274	1.0704566635	0.847110681748771	0.488832	0	1.18048328458756	0.488757	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0003844,1,4-alpha-glucan branching enzyme activity;GO:0102752,1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis);GO:0030246,carbohydrate binding;GO:0043169,cation binding;GO:0004553,hydrolase activity, hydrolyzing O-glycosyl compounds	GO:0005975,carbohydrate metabolic process;GO:0006091,generation of precursor metabolites and energy;GO:0005978,glycogen biosynthetic process;GO:0005977,glycogen metabolic process;GO:0043524,negative regulation of neuron apoptotic process	hsa:2632,path:hsa00500,Starch and sucrose metabolism
RL1D1_HUMAN	O76021	RSL1D1	Ribosomal L1 domain-containing protein 1	0.042459061	0.104636715	0.083370792	0.011212364	0.073547888	0.047291578	0.073547888	0.047291578	1.55520054754781	0.294578	0	0.643003888840425	0.294119	0	GO:0030686,90S preribosome;GO:0005694,chromosome;GO:0016020,membrane;GO:0005730,nucleolus	GO:0045296,cadherin binding;GO:0003730,mRNA 3'-UTR binding;GO:0048027,mRNA 5'-UTR binding;GO:0003723,RNA binding	GO:0000470,maturation of LSU-rRNA;GO:0001649,osteoblast differentiation;GO:0042981,regulation of apoptotic process;GO:2000772,regulation of cellular senescence;GO:0032880,regulation of protein localization	
RL13A_HUMAN	P40429	RPL13A	60S ribosomal protein L13a	2.434230618	1.972170298	0.508137366	0.093968674	2.203200458	0.30105302	2.203200458	0.30105302	7.31831375749029	0.032485	1	0.136643499190848	0.032177	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0005925,focal adhesion;GO:0097452,GAIT complex;GO:0015934,large ribosomal subunit;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0005840,ribosome	GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0071346,cellular response to interferon-gamma;GO:0002181,cytoplasmic translation;GO:1901194,negative regulation of formation of translation preinitiation complex;GO:0017148,negative regulation of translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription;GO:0006417,regulation of translation	hsa:23521,path:hsa03010,Ribosome
PBIP1_HUMAN	Q96AQ6	PBXIP1	Pre-B-cell leukemia transcription factor-interacting protein 1	0.137626281	0.371859433	0.351526538	0.26510382	0.254742857	0.308315179	0.254742857	0.308315179	0.826241697947671	0.497218	0	1.21029960420048	0.497162	0	GO:0005829,cytosol;GO:0016020,membrane;GO:0005874,microtubule;GO:0005634,nucleus	GO:0003714,transcription corepressor activity	GO:0030154,cell differentiation;GO:0007275,multicellular organism development;GO:0045892,negative regulation of transcription, DNA-templated;GO:2001106,regulation of Rho guanyl-nucleotide exchange factor activity	
RRAGC_HUMAN	Q9HB90	RRAGC	Ras-related GTP-binding protein C	0.298112928	0.455065753	0.773212147	0.661324129	0.3765893405	0.717268138	0.3765893405	0.717268138	0.525032858074619	0.248160	0	1.90464269925346	0.248480	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:1990131,Gtr1-Gtr2 GTPase complex;GO:0043231,intracellular membrane-bounded organelle;GO:0005764,lysosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0071986,Ragulator complex	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0051020,GTPase binding;GO:0000287,magnesium ion binding;GO:0046982,protein heterodimerization activity	GO:0006915,apoptotic process;GO:0007050,cell cycle arrest;GO:0034613,cellular protein localization;GO:0034198,cellular response to amino acid starvation;GO:0071230,cellular response to amino acid stimulus;GO:0009267,cellular response to starvation;GO:0032008,positive regulation of TOR signaling;GO:0010506,regulation of autophagy;GO:0016241,regulation of macroautophagy;GO:0032006,regulation of TOR signaling;GO:1903432,regulation of TORC1 signaling;GO:0043200,response to amino acid;GO:0008380,RNA splicing;GO:0007264,small GTPase mediated signal transduction;GO:0006351,transcription, DNA-templated	hsa:64121,path:hsa04150,mTOR signaling pathway;hsa:64121,path:hsa04140,Autophagy - animal;hsa:64121,path:hsa05131,Shigellosis
PGK1_HUMAN	P00558	PGK1	Phosphoglycerate kinase 1	66.13403554	97.64385169	80.03831937	61.62711956	81.888943615	70.832719465	81.888943615	70.832719465	1.15608922308091	0.385870	0	0.864985141315527	0.385574	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0016020,membrane;GO:0045121,membrane raft	GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0004618,phosphoglycerate kinase activity;GO:0047134,protein-disulfide reductase activity	GO:0061621,canonical glycolysis;GO:0071456,cellular response to hypoxia;GO:0030855,epithelial cell differentiation;GO:0006094,gluconeogenesis;GO:0006096,glycolytic process;GO:0044003,modulation by symbiont of host process;GO:0016525,negative regulation of angiogenesis;GO:0016310,phosphorylation;GO:0031639,plasminogen activation	hsa:5230,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:5230,path:hsa04066,HIF-1 signaling pathway
PECA1_HUMAN	P16284	PECAM1	Platelet endothelial cell adhesion molecule	0.882893761	1.454533431	1.959364369	6.457318085	1.168713596	4.208341227	1.168713596	4.208341227	0.277713600908057	0.049108	-1	3.60083192443669	0.049324	1	GO:0005911,cell-cell junction;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005887,integral component of plasma membrane;GO:0045121,membrane raft;GO:0005886,plasma membrane;GO:0031092,platelet alpha granule membrane;GO:0032991,protein-containing complex;GO:0030667,secretory granule membrane	GO:0042803,protein homodimerization activity;GO:0004888,transmembrane signaling receptor activity	GO:0070830,bicellular tight junction assembly;GO:0008037,cell recognition;GO:0007166,cell surface receptor signaling pathway;GO:0098609,cell-cell adhesion;GO:0098742,cell-cell adhesion via plasma-membrane adhesion molecules;GO:0050904,diapedesis;GO:0061028,establishment of endothelial barrier;GO:0030198,extracellular matrix organization;GO:0072011,glomerular endothelium development;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007159,leukocyte cell-cell adhesion;GO:0050900,leukocyte migration;GO:0035633,maintenance of blood-brain barrier;GO:0035696,monocyte extravasation;GO:0043312,neutrophil degranulation;GO:0072672,neutrophil extravasation;GO:0006909,phagocytosis;GO:0002576,platelet degranulation;GO:0030335,positive regulation of cell migration;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0150107,positive regulation of protein localization to cell-cell junction;GO:0001934,positive regulation of protein phosphorylation;GO:0007165,signal transduction	hsa:5175,path:hsa04514,Cell adhesion molecules (CAMs);hsa:5175,path:hsa04670,Leukocyte transendothelial migration;hsa:5175,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:5175,path:hsa05144,Malaria
ANXA7_HUMAN	P20073	ANXA7	Annexin A7	4.262462693	5.165763459	6.037148413	9.860821323	4.714113076	7.948984868	4.714113076	7.948984868	0.593045924011941	0.310605	0	1.68621005475432	0.310885	0	GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005634,nucleus	GO:0005509,calcium ion binding;GO:0005544,calcium-dependent phospholipid binding;GO:0048306,calcium-dependent protein binding;GO:0005178,integrin binding;GO:0003723,RNA binding	GO:0006914,autophagy;GO:0030855,epithelial cell differentiation;GO:0061025,membrane fusion;GO:0010629,negative regulation of gene expression;GO:0051592,response to calcium ion;GO:0014070,response to organic cyclic compound	
SEH1_HUMAN	Q96EE3	SEH1L	Nucleoporin SEH1	0.164482997	0.200024854	0.3430179	0.180453381	0.1822539255	0.2617356405	0.1822539255	0.2617356405	0.696328269057419	0.401764	0	1.43610426926031	0.401963	0	GO:0000777,condensed chromosome kinetochore;GO:0005829,cytosol;GO:0061700,GATOR2 complex;GO:0043657,host cell;GO:0005765,lysosomal membrane;GO:0005635,nuclear envelope;GO:0031080,nuclear pore outer ring;GO:0035859,Seh1-associated complex	GO:0005198,structural molecule activity	GO:0051315,attachment of mitotic spindle microtubules to kinetochore;GO:0051301,cell division;GO:0034629,cellular protein-containing complex localization;GO:0034198,cellular response to amino acid starvation;GO:0050830,defense response to Gram-positive bacterium;GO:0075733,intracellular transport of virus;GO:0007080,mitotic metaphase plate congression;GO:0007084,mitotic nuclear envelope reassembly;GO:0007052,mitotic spindle organization;GO:0006406,mRNA export from nucleus;GO:0006999,nuclear pore organization;GO:0032008,positive regulation of TOR signaling;GO:1904263,positive regulation of TORC1 signaling;GO:0016925,protein sumoylation;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription;GO:0015031,protein transport	hsa:81929,path:hsa03013,RNA transport;hsa:81929,path:hsa04150,mTOR signaling pathway
BI2L1_HUMAN	Q9UHR4	BAIAP2L1	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	0.029367413	0.125683675	0.066527271	0.078159493	0.077525544	0.072343382	0.077525544	0.072343382	1.07163284127358	0.410538	0	0.933155425520136	0.410293	0	GO:0005912,adherens junction;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0003779,actin binding;GO:0098641,cadherin binding involved in cell-cell adhesion;GO:0070064,proline-rich region binding	GO:0051764,actin crosslink formation;GO:0051017,actin filament bundle assembly;GO:0007009,plasma membrane organization;GO:2000251,positive regulation of actin cytoskeleton reorganization;GO:0030838,positive regulation of actin filament polymerization;GO:0046626,regulation of insulin receptor signaling pathway;GO:0009617,response to bacterium	hsa:55971,path:hsa05130,Pathogenic Escherichia coli infection
DHB4_HUMAN	P51659	HSD17B4	Peroxisomal multifunctional enzyme type 2	17.75353597	20.7941563	40.97738371	29.39570707	19.273846135	35.18654539	19.273846135	35.18654539	0.547761819791426	0.269104	0	1.82561099344378	0.269412	0	GO:0005829,cytosol;GO:0016020,membrane;GO:0005782,peroxisomal matrix;GO:0005778,peroxisomal membrane;GO:0005777,peroxisome	GO:0044594,17-beta-hydroxysteroid dehydrogenase (NAD+) activity;GO:0003857,3-hydroxyacyl-CoA dehydrogenase activity;GO:0033989,3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity;GO:0004300,enoyl-CoA hydratase activity;GO:0016853,isomerase activity;GO:0016508,long-chain-enoyl-CoA hydratase activity;GO:0042803,protein homodimerization activity;GO:0016491,oxidoreductase activity	GO:0036109,alpha-linolenic acid metabolic process;GO:0008209,androgen metabolic process;GO:0006699,bile acid biosynthetic process;GO:0008210,estrogen metabolic process;GO:0006635,fatty acid beta-oxidation;GO:0033540,fatty acid beta-oxidation using acyl-CoA oxidase;GO:0036112,medium-chain fatty-acyl-CoA metabolic process;GO:0001649,osteoblast differentiation;GO:0008104,protein localization;GO:0060009,Sertoli cell development;GO:0000038,very long-chain fatty acid metabolic process;GO:0036111,very long-chain fatty-acyl-CoA metabolic process	hsa:3295,path:hsa00120,Primary bile acid biosynthesis;hsa:3295,path:hsa01040,Biosynthesis of unsaturated fatty acids;hsa:3295,path:hsa04146,Peroxisome
TF65_HUMAN	Q04206	RELA	Transcription factor p65	1.339435146	0.83389778	1.01114937	1.630156578	1.086666463	1.320652974	1.086666463	1.320652974	0.822825136045164	0.498611	0	1.21532505047963	0.498558	0	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0098978,glutamatergic synapse;GO:0035525,NF-kappaB p50/p65 complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005667,transcription regulator complex;GO:0071159,NF-kappaB complex	GO:0042805,actinin binding;GO:0033613,activating transcription factor binding;GO:0071532,ankyrin repeat binding;GO:0003682,chromatin binding;GO:0031490,chromatin DNA binding;GO:0003677,DNA binding;GO:0001228,DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700,DNA-binding transcription factor activity;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0140297,DNA-binding transcription factor binding;GO:0001227,DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0019899,enzyme binding;GO:0042826,histone deacetylase binding;GO:0042802,identical protein binding;GO:0051059,NF-kappaB binding;GO:0042277,peptide binding;GO:0042301,phosphate ion binding;GO:0042803,protein homodimerization activity;GO:0019901,protein kinase binding;GO:0047485,protein N-terminus binding;GO:0044877,protein-containing complex binding;GO:0070491,repressing transcription factor binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000979,RNA polymerase II core promoter sequence-specific DNA binding;GO:0001225,RNA polymerase II transcription coactivator binding;GO:0000977,RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0008134,transcription factor binding;GO:0000976,transcription regulatory region sequence-specific DNA binding;GO:0031625,ubiquitin protein ligase binding	GO:0006117,acetaldehyde metabolic process;GO:0007568,aging;GO:0009887,animal organ morphogenesis;GO:0006968,cellular defense response;GO:1904385,cellular response to angiotensin;GO:0035729,cellular response to hepatocyte growth factor stimulus;GO:0070301,cellular response to hydrogen peroxide;GO:0071347,cellular response to interleukin-1;GO:0071354,cellular response to interleukin-6;GO:0071222,cellular response to lipopolysaccharide;GO:0071223,cellular response to lipoteichoic acid;GO:0071316,cellular response to nicotine;GO:0071224,cellular response to peptidoglycan;GO:0071356,cellular response to tumor necrosis factor;GO:0035924,cellular response to vascular endothelial growth factor stimulus;GO:0006325,chromatin organization;GO:0019221,cytokine-mediated signaling pathway;GO:0051607,defense response to virus;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0001942,hair follicle development;GO:0007249,I-kappaB kinase/NF-kappaB signaling;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0070498,interleukin-1-mediated signaling pathway;GO:0001889,liver development;GO:0031293,membrane protein intracellular domain proteolysis;GO:0043066,negative regulation of apoptotic process;GO:2001237,negative regulation of extrinsic apoptotic signaling pathway;GO:0046627,negative regulation of insulin receptor signaling pathway;GO:1901223,negative regulation of NIK/NF-kappaB signaling;GO:1902894,negative regulation of pri-miRNA transcription by RNA polymerase II;GO:0042177,negative regulation of protein catabolic process;GO:0033234,negative regulation of protein sumoylation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0038061,NIK/NF-kappaB signaling;GO:0070431,nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:1902004,positive regulation of amyloid-beta formation;GO:0008284,positive regulation of cell population proliferation;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0032735,positive regulation of interleukin-12 production;GO:0032757,positive regulation of interleukin-8 production;GO:1904996,positive regulation of leukocyte adhesion to vascular endothelial cell;GO:2000630,positive regulation of miRNA metabolic process;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:1902895,positive regulation of pri-miRNA transcription by RNA polymerase II;GO:0014040,positive regulation of Schwann cell differentiation;GO:0050862,positive regulation of T cell receptor signaling pathway;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:1901522,positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;GO:0045893,positive regulation of transcription, DNA-templated;GO:0032481,positive regulation of type I interferon production;GO:0099527,postsynapse to nucleus signaling pathway;GO:0043620,regulation of DNA-templated transcription in response to stress;GO:0050727,regulation of inflammatory response;GO:1901222,regulation of NIK/NF-kappaB signaling;GO:0006357,regulation of transcription by RNA polymerase II;GO:0060260,regulation of transcription initiation from RNA polymerase II promoter;GO:0006355,regulation of transcription, DNA-templated;GO:0043200,response to amino acid;GO:0051591,response to cAMP;GO:0033590,response to cobalamin;GO:0034097,response to cytokine;GO:0042493,response to drug;GO:0032868,response to insulin;GO:0070555,response to interleukin-1;GO:0043278,response to morphine;GO:0032495,response to muramyl dipeptide;GO:0035994,response to muscle stretch;GO:0010033,response to organic substance;GO:0032570,response to progesterone;GO:0010224,response to UV-B;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0006351,transcription, DNA-templated;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process	hsa:5970,path:hsa04014,Ras signaling pathway;hsa:5970,path:hsa04010,MAPK signaling pathway;hsa:5970,path:hsa04064,NF-kappa B signaling pathway;hsa:5970,path:hsa04668,TNF signaling pathway;hsa:5970,path:hsa04066,HIF-1 signaling pathway;hsa:5970,path:hsa04071,Sphingolipid signaling pathway;hsa:5970,path:hsa04024,cAMP signaling pathway;hsa:5970,path:hsa04151,PI3K-Akt signaling pathway;hsa:5970,path:hsa04137,Mitophagy - animal;hsa:5970,path:hsa04210,Apoptosis;hsa:5970,path:hsa04218,Cellular senescence;hsa:5970,path:hsa04620,Toll-like receptor signaling pathway;hsa:5970,path:hsa04621,NOD-like receptor signaling pathway;hsa:5970,path:hsa04622,RIG-I-like receptor signaling pathway;hsa:5970,path:hsa04623,Cytosolic DNA-sensing pathway;hsa:5970,path:hsa04625,C-type lectin receptor signaling pathway;hsa:5970,path:hsa04660,T cell receptor signaling pathway;hsa:5970,path:hsa04658,Th1 and Th2 cell differentiation;hsa:5970,path:hsa04659,Th17 cell differentiation;hsa:5970,path:hsa04657,IL-17 signaling pathway;hsa:5970,path:hsa04662,B cell receptor signaling pathway;hsa:5970,path:hsa04062,Chemokine signaling pathway;hsa:5970,path:hsa04920,Adipocytokine signaling pathway;hsa:5970,path:hsa04917,Prolactin signaling pathway;hsa:5970,path:hsa04926,Relaxin signaling pathway;hsa:5970,path:hsa04722,Neurotrophin signaling pathway;hsa:5970,path:hsa04380,Osteoclast differentiation;hsa:5970,path:hsa04211,Longevity regulating pathway;hsa:5970,path:hsa05200,Pathways in cancer;hsa:5970,path:hsa05202,Transcriptional misregulation in cancer;hsa:5970,path:hsa05203,Viral carcinogenesis;hsa:5970,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:5970,path:hsa05212,Pancreatic cancer;hsa:5970,path:hsa05221,Acute myeloid leukemia;hsa:5970,path:hsa05220,Chronic myeloid leukemia;hsa:5970,path:hsa05215,Prostate cancer;hsa:5970,path:hsa05222,Small cell lung cancer;hsa:5970,path:hsa05321,Inflammatory bowel disease (IBD);hsa:5970,path:hsa05030,Cocaine addiction;hsa:5970,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:5970,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:5970,path:hsa04931,Insulin resistance;hsa:5970,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:5970,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:5970,path:hsa05130,Pathogenic Escherichia coli infection;hsa:5970,path:hsa05132,Salmonella infection;hsa:5970,path:hsa05131,Shigellosis;hsa:5970,path:hsa05135,Yersinia infection;hsa:5970,path:hsa05133,Pertussis;hsa:5970,path:hsa05134,Legionellosis;hsa:5970,path:hsa05152,Tuberculosis;hsa:5970,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:5970,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:5970,path:hsa05162,Measles;hsa:5970,path:hsa05164,Influenza A;hsa:5970,path:hsa05161,Hepatitis B;hsa:5970,path:hsa05160,Hepatitis C;hsa:5970,path:hsa05168,Herpes simplex virus 1 infection;hsa:5970,path:hsa05163,Human cytomegalovirus infection;hsa:5970,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:5970,path:hsa05169,Epstein-Barr virus infection;hsa:5970,path:hsa05165,Human papillomavirus infection;hsa:5970,path:hsa05146,Amoebiasis;hsa:5970,path:hsa05145,Toxoplasmosis;hsa:5970,path:hsa05140,Leishmaniasis;hsa:5970,path:hsa05142,Chagas disease (American trypanosomiasis);hsa:5970,path:hsa01523,Antifolate resistance
AIDA_HUMAN	Q96BJ3	AIDA	Axin interactor, dorsalization-associated protein	0.46749106	0.230017464	0.370151803	0.4287732	0.348754262	0.3994625015	0.348754262	0.3994625015	0.87305882452148	0.478695	0	1.1453981930119	0.478598	0	GO:0005737,cytoplasm;GO:0016020,membrane	GO:0035091,phosphatidylinositol binding;GO:0019904,protein domain specific binding	GO:0048264,determination of ventral identity;GO:0009953,dorsal/ventral pattern formation;GO:0046329,negative regulation of JNK cascade;GO:0043508,negative regulation of JUN kinase activity;GO:0031333,negative regulation of protein-containing complex assembly	
PUR4_HUMAN	O15067	PFAS	Phosphoribosylformylglycinamidine synthase	0.499179276	0.527328059	0.807573326	0.604696456	0.5132536675	0.706134891	0.5132536675	0.706134891	0.726849323042444	0.427311	0	1.3758009649293	0.427482	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0005524,ATP binding;GO:0046872,metal ion binding;GO:0004642,phosphoribosylformylglycinamidine synthase activity	GO:0006189,'de novo' IMP biosynthetic process;GO:0097065,anterior head development;GO:0006541,glutamine metabolic process;GO:0009168,purine ribonucleoside monophosphate biosynthetic process;GO:0042493,response to drug;GO:0006164,purine nucleotide biosynthetic process	hsa:5198,path:hsa00230,Purine metabolism
LACB2_HUMAN	Q53H82	LACTB2	Endoribonuclease LACTB2	0.118721288	0.092151845	0.136526058	2.55E-05	0.1054365665	0.068275779	0.1054365665	0.068275779	1.54427482255457	0.296630	0	0.647553133286069	0.296174	0	GO:0005759,mitochondrial matrix	GO:0004521,endoribonuclease activity;GO:0003727,single-stranded RNA binding;GO:0008270,zinc ion binding	GO:0090502,RNA phosphodiester bond hydrolysis, endonucleolytic	
C1QB_HUMAN	P02746	C1QB	Complement C1q subcomponent subunit B	2.152129344	3.812284982	1.729889862	3.590633309	2.982207163	2.6602615855	2.982207163	2.6602615855	1.121020270809	0.395837	0	0.892044529469866	0.395562	0	GO:0072562,blood microparticle;GO:0005581,collagen trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005602,complement component C1 complex;GO:0005576,extracellular region;GO:0098794,postsynapse;GO:0045202,synapse		GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0045087,innate immune response;GO:0030449,regulation of complement activation;GO:0098883,synapse pruning;GO:0048839,inner ear development	hsa:713,path:hsa04610,Complement and coagulation cascades;hsa:713,path:hsa05322,Systemic lupus erythematosus;hsa:713,path:hsa05020,Prion diseases;hsa:713,path:hsa05133,Pertussis;hsa:713,path:hsa05150,Staphylococcus aureus infection;hsa:713,path:hsa05142,Chagas disease (American trypanosomiasis)
ASPH_HUMAN	Q12797	ASPH	Aspartyl/asparaginyl beta-hydroxylase	1.315009145	4.040947335	2.218962094	2.550987875	2.67797824	2.3849749845	2.67797824	2.3849749845	1.12285380660352	0.395307	0	0.890587887861255	0.395030	0	GO:0034704,calcium channel complex;GO:0032541,cortical endoplasmic reticulum;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0014701,junctional sarcoplasmic reticulum membrane;GO:0005886,plasma membrane;GO:0033018,sarcoplasmic reticulum lumen;GO:0033017,sarcoplasmic reticulum membrane	GO:0005509,calcium ion binding;GO:0009055,electron transfer activity;GO:0044325,ion channel binding;GO:0004597,peptide-aspartate beta-dioxygenase activity;GO:0062101,peptidyl-aspartic acid 3-dioxygenase activity;GO:0008307,structural constituent of muscle;GO:0005198,structural molecule activity	GO:0097202,activation of cysteine-type endopeptidase activity;GO:0032237,activation of store-operated calcium channel activity;GO:0055074,calcium ion homeostasis;GO:0070588,calcium ion transmembrane transport;GO:0071277,cellular response to calcium ion;GO:0005513,detection of calcium ion;GO:0034220,ion transmembrane transport;GO:0006936,muscle contraction;GO:0042264,peptidyl-aspartic acid hydroxylation;GO:0010524,positive regulation of calcium ion transport into cytosol;GO:0090316,positive regulation of intracellular protein transport;GO:0045862,positive regulation of proteolysis;GO:0060316,positive regulation of ryanodine-sensitive calcium-release channel activity;GO:0045893,positive regulation of transcription, DNA-templated;GO:1903779,regulation of cardiac conduction;GO:0010881,regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0010649,regulation of cell communication by electrical coupling;GO:0031585,regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity;GO:0010880,regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0060314,regulation of ryanodine-sensitive calcium-release channel activity;GO:0033198,response to ATP	hsa:444,path:hsa04020,Calcium signaling pathway;hsa:444,path:hsa04260,Cardiac muscle contraction
PSD11_HUMAN	O00231	PSMD11	26S proteasome non-ATPase regulatory subunit 11	12.61552254	8.34689326	12.54107189	13.70430351	10.4812079	13.1226877	10.4812079	13.1226877	0.798708933688942	0.484386	0	1.25202055194421	0.484494	0	GO:0005829,cytosol;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0022624,proteasome accessory complex;GO:0000502,proteasome complex;GO:0008541,proteasome regulatory particle, lid subcomplex;GO:0034774,secretory granule lumen	GO:0005198,structural molecule activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0043312,neutrophil degranulation;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043248,proteasome assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0048863,stem cell differentiation;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5717,path:hsa03050,Proteasome;hsa:5717,path:hsa05169,Epstein-Barr virus infection
HEMH_HUMAN	P22830	FECH	Ferrochelatase, mitochondrial	0.05224551	2.55E-05	0.317737052	0.560584357	0.026135505	0.4391607045	0.026135505	0.4391607045	0.0595123942834462	0.000031	-1	16.8032224554299	0.000031	1	GO:0005743,mitochondrial inner membrane;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0051537,2 iron, 2 sulfur cluster binding;GO:0004325,ferrochelatase activity;GO:0008198,ferrous iron binding	GO:0071549,cellular response to dexamethasone stimulus;GO:0006091,generation of precursor metabolites and energy;GO:0006783,heme biosynthetic process;GO:0046501,protoporphyrinogen IX metabolic process;GO:0046685,response to arsenic-containing substance;GO:0042493,response to drug;GO:0045471,response to ethanol;GO:0017085,response to insecticide;GO:0010288,response to lead ion;GO:0009416,response to light stimulus;GO:0051597,response to methylmercury;GO:0070541,response to platinum ion	hsa:2235,path:hsa00860,Porphyrin and chlorophyll metabolism
GELS_HUMAN	P06396	GSN	Gelsolin	51.91047406	101.5273256	48.02684249	122.1947943	76.71889983	85.110818395	76.71889983	85.110818395	0.9014000955078	0.467978	0	1.10938528294326	0.467856	0	GO:0030478,actin cap;GO:0015629,actin cytoskeleton;GO:0072562,blood microparticle;GO:0030864,cortical actin cytoskeleton;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0043209,myelin sheath;GO:0048471,perinuclear region of cytoplasm;GO:0045335,phagocytic vesicle;GO:0005886,plasma membrane;GO:0002102,podosome;GO:0032991,protein-containing complex;GO:0001726,ruffle;GO:0016528,sarcoplasm;GO:0034774,secretory granule lumen;GO:0042470,melanosome;GO:0005634,nucleus	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0005509,calcium ion binding;GO:0045159,myosin II binding;GO:0036313,phosphatidylinositol 3-kinase catalytic subunit binding;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding	GO:0051693,actin filament capping;GO:0030042,actin filament depolymerization;GO:0030041,actin filament polymerization;GO:0090527,actin filament reorganization;GO:0051014,actin filament severing;GO:0045010,actin nucleation;GO:0008154,actin polymerization or depolymerization;GO:0007568,aging;GO:1990000,amyloid fibril formation;GO:0051016,barbed-end actin filament capping;GO:0086003,cardiac muscle cell contraction;GO:0030031,cell projection assembly;GO:0071276,cellular response to cadmium ion;GO:0071346,cellular response to interferon-gamma;GO:0007417,central nervous system development;GO:0060271,cilium assembly;GO:0097284,hepatocyte apoptotic process;GO:0046597,negative regulation of viral entry into host cell;GO:0043312,neutrophil degranulation;GO:0014003,oligodendrocyte development;GO:0006911,phagocytosis, engulfment;GO:0048015,phosphatidylinositol-mediated signaling;GO:0051127,positive regulation of actin nucleation;GO:2001269,positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:0010628,positive regulation of gene expression;GO:1902174,positive regulation of keratinocyte apoptotic process;GO:1903923,positive regulation of protein processing in phagocytic vesicle;GO:0031648,protein destabilization;GO:0030155,regulation of cell adhesion;GO:1903903,regulation of establishment of T cell polarity;GO:1903906,regulation of plasma membrane raft polarization;GO:0071801,regulation of podosome assembly;GO:1903909,regulation of receptor clustering;GO:0055119,relaxation of cardiac muscle;GO:0097017,renal protein absorption;GO:0045471,response to ethanol;GO:0051593,response to folic acid;GO:0035994,response to muscle stretch;GO:0042989,sequestering of actin monomers;GO:0014891,striated muscle atrophy;GO:0042246,tissue regeneration;GO:0042060,wound healing;GO:0030030,cell projection organization	hsa:2934,path:hsa04810,Regulation of actin cytoskeleton;hsa:2934,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:2934,path:hsa05203,Viral carcinogenesis
GOGB1_HUMAN	Q14789	GOLGB1	Golgin subfamily B member 1	1.845154423	0.620498817	1.539002669	1.749792996	1.23282662	1.6443978325	1.23282662	1.6443978325	0.74971311420772	0.445952	0	1.33384354768394	0.446104	0	GO:0005801,cis-Golgi network;GO:0005829,cytosol;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005795,Golgi stack;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0003723,RNA binding;GO:0043565,sequence-specific DNA binding	GO:0035988,chondrocyte proliferation;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030,Golgi organization;GO:0006892,post-Golgi vesicle-mediated transport;GO:1905793,protein localization to pericentriolar material;GO:0006355,regulation of transcription, DNA-templated	
GALE_HUMAN	Q14376	GALE	UDP-glucose 4-epimerase	0.896973976	0.873205688	1.511405474	2.417309736	0.885089832	1.964357605	0.885089832	1.964357605	0.450574696657638	0.180355	0	2.21938783384419	0.180691	0	GO:0005829,cytosol	GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:0003978,UDP-glucose 4-epimerase activity;GO:0003974,UDP-N-acetylglucosamine 4-epimerase activity	GO:0019388,galactose catabolic process;GO:0033499,galactose catabolic process via UDP-galactose;GO:0006012,galactose metabolic process	hsa:2582,path:hsa00052,Galactose metabolism;hsa:2582,path:hsa00520,Amino sugar and nucleotide sugar metabolism
SNX2_HUMAN	O60749	SNX2	Sorting nexin-2	4.088571203	6.947410043	5.929135404	6.950947166	5.517990623	6.440041285	5.517990623	6.440041285	0.856825349218239	0.485000	0	1.16709899037463	0.484916	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0030027,lamellipodium;GO:0005764,lysosome;GO:0016020,membrane;GO:0032991,protein-containing complex;GO:0030904,retromer complex;GO:0030905,retromer, tubulation complex	GO:0045296,cadherin binding;GO:0005154,epidermal growth factor receptor binding;GO:0042802,identical protein binding;GO:0005158,insulin receptor binding;GO:1990460,leptin receptor binding;GO:0035091,phosphatidylinositol binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:1990459,transferrin receptor binding	GO:0034498,early endosome to Golgi transport;GO:0006897,endocytosis;GO:0006886,intracellular protein transport;GO:0072673,lamellipodium morphogenesis;GO:0042147,retrograde transport, endosome to Golgi	hsa:6643,path:hsa04144,Endocytosis
CO2_HUMAN	P06681	C2	Complement C2	0.829754755	0.759138323	0.920389765	2.213817336	0.794446539	1.5671035505	0.794446539	1.5671035505	0.506952165826262	0.231521	0	1.97257269503946	0.231848	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0046872,metal ion binding;GO:0004252,serine-type endopeptidase activity	GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0045087,innate immune response;GO:2000427,positive regulation of apoptotic cell clearance;GO:0030449,regulation of complement activation;GO:0007584,response to nutrient	hsa:717,path:hsa04610,Complement and coagulation cascades;hsa:717,path:hsa05322,Systemic lupus erythematosus;hsa:717,path:hsa05133,Pertussis;hsa:717,path:hsa05150,Staphylococcus aureus infection
SEPT1_HUMAN	Q8WYJ6	SEPTIN1	Septin-1	4.690774814	2.154294135	7.29514144	3.911026444	3.4225344745	5.603083942	3.4225344745	5.603083942	0.610830483699364	0.326722	0	1.63711541366389	0.326990	0	GO:0032153,cell division site;GO:0015630,microtubule cytoskeleton;GO:0005815,microtubule organizing center;GO:0030496,midbody;GO:0031105,septin complex;GO:0005940,septin ring;GO:0008021,synaptic vesicle;GO:0072687,meiotic spindle	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0060090,molecular adaptor activity	GO:0034613,cellular protein localization;GO:0061640,cytoskeleton-dependent cytokinesis;GO:0017157,regulation of exocytosis;GO:0051311,meiotic metaphase plate congression;GO:0007056,spindle assembly involved in female meiosis	hsa:1731,path:hsa05100,Bacterial invasion of epithelial cells
KIF2A_HUMAN	O00139	KIF2A	Kinesin-like protein KIF2A	0.29041142	0.229030684	0.558724189	0.163894524	0.259721052	0.3613093565	0.259721052	0.3613093565	0.718832898533033	0.420672	0	1.39114389733798	0.420851	0	GO:0120103,centriolar subdistal appendage;GO:0005814,centriole;GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005871,kinesin complex;GO:0016020,membrane;GO:0005874,microtubule;GO:0016604,nuclear body;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005819,spindle;GO:0000922,spindle pole	GO:0005524,ATP binding;GO:1990939,ATP-dependent microtubule motor activity;GO:0016887,ATPase activity;GO:0008017,microtubule binding;GO:0003777,microtubule motor activity;GO:0003774,motor activity	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0030154,cell differentiation;GO:0051301,cell division;GO:0000226,microtubule cytoskeleton organization;GO:0007019,microtubule depolymerization;GO:0007018,microtubule-based movement;GO:0090307,mitotic spindle assembly;GO:0007052,mitotic spindle organization;GO:0007399,nervous system development;GO:0030334,regulation of cell migration;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	
CN37_HUMAN	P09543	CNP	2',3'-cyclic-nucleotide 3'-phosphodiesterase	1.485499557	1.707831789	1.492140513	2.242340687	1.596665673	1.8672406	1.596665673	1.8672406	0.855093699762098	0.485680	0	1.16946248145463	0.485598	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0042470,melanosome;GO:0016020,membrane;GO:0005874,microtubule;GO:0005902,microvillus;GO:0005743,mitochondrial inner membrane;GO:0005741,mitochondrial outer membrane;GO:0035748,myelin sheath abaxonal region;GO:0035749,myelin sheath adaxonal region;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0031143,pseudopodium;GO:0045202,synapse	GO:0004113,2',3'-cyclic-nucleotide 3'-phosphodiesterase activity;GO:0030551,cyclic nucleotide binding;GO:0003723,RNA binding	GO:0008344,adult locomotory behavior;GO:0007568,aging;GO:0007409,axonogenesis;GO:0007268,chemical synaptic transmission;GO:0009214,cyclic nucleotide catabolic process;GO:0030900,forebrain development;GO:0000226,microtubule cytoskeleton organization;GO:0048709,oligodendrocyte differentiation;GO:0046902,regulation of mitochondrial membrane permeability;GO:0032496,response to lipopolysaccharide;GO:0009636,response to toxic substance;GO:0021762,substantia nigra development	
RL9_HUMAN	P32969	RPL9	60S ribosomal protein L9	3.933670203	7.135988982	1.965383134	0.879799492	5.5348295925	1.422591313	5.5348295925	1.422591313	3.89066736308687	0.094601	0	0.257025313828576	0.094086	0	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005634,nucleus;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0019843,rRNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6133,path:hsa03010,Ribosome
GYS1_HUMAN	P13807	GYS1	Glycogen [starch] synthase, muscle	0.306689008	0.214025186	0.625260546	0.299099186	0.260357097	0.462179866	0.260357097	0.462179866	0.563324186432647	0.283420	0	1.77517675271975	0.283719	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016234,inclusion body;GO:0016020,membrane	GO:0005536,glucose binding;GO:0004373,glycogen (starch) synthase activity;GO:0061547,glycogen synthase activity, transferring glucose-1-phosphate;GO:0019901,protein kinase binding	GO:0005978,glycogen biosynthetic process;GO:0007507,heart development	hsa:2997,path:hsa00500,Starch and sucrose metabolism;hsa:2997,path:hsa04151,PI3K-Akt signaling pathway;hsa:2997,path:hsa04152,AMPK signaling pathway;hsa:2997,path:hsa04910,Insulin signaling pathway;hsa:2997,path:hsa04922,Glucagon signaling pathway;hsa:2997,path:hsa04931,Insulin resistance
CSN3_HUMAN	Q9UNS2	COPS3	COP9 signalosome complex subunit 3	0.332326539	0.038608983	0.093157356	0.098304891	0.185467761	0.0957311235	0.185467761	0.0957311235	1.93738205736194	0.234145	0	0.516160452813144	0.233610	0	GO:0008180,COP9 signalosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm		GO:0001701,in utero embryonic development;GO:0000715,nucleotide-excision repair, DNA damage recognition;GO:0043687,post-translational protein modification;GO:0000338,protein deneddylation;GO:0009416,response to light stimulus;GO:0007165,signal transduction;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0006511,ubiquitin-dependent protein catabolic process	
CAD13_HUMAN	P55290	CDH13	Cadherin-13	0.243806035	0.028005277	0.142377491	1.223103408	0.135905656	0.6827404495	0.135905656	0.6827404495	0.199059036416444	0.015292	-1	5.02363528932159	0.015397	1	GO:0031225,anchored component of membrane;GO:0016342,catenin complex;GO:0005901,caveola;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0098982,GABA-ergic synapse;GO:0043005,neuron projection;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane	GO:0055100,adiponectin binding;GO:0045296,cadherin binding;GO:0005509,calcium ion binding;GO:0071813,lipoprotein particle binding;GO:0030169,low-density lipoprotein particle binding;GO:0042803,protein homodimerization activity	GO:0034332,adherens junction organization;GO:0016339,calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0098742,cell-cell adhesion via plasma-membrane adhesion molecules;GO:0043542,endothelial cell migration;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0043616,keratinocyte proliferation;GO:0030032,lamellipodium assembly;GO:0051668,localization within membrane;GO:0055096,low-density lipoprotein particle mediated signaling;GO:0000278,mitotic cell cycle;GO:0007162,negative regulation of cell adhesion;GO:0008285,negative regulation of cell population proliferation;GO:0050850,positive regulation of calcium-mediated signaling;GO:0030335,positive regulation of cell migration;GO:0001954,positive regulation of cell-matrix adhesion;GO:0001938,positive regulation of endothelial cell proliferation;GO:0050927,positive regulation of positive chemotaxis;GO:0048661,positive regulation of smooth muscle cell proliferation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0016601,Rac protein signal transduction;GO:0030100,regulation of endocytosis;GO:0042058,regulation of epidermal growth factor receptor signaling pathway;GO:0007266,Rho protein signal transduction;GO:0002040,sprouting angiogenesis	
A2MG_HUMAN	P01023	A2M	Alpha-2-macroglobulin	23.87268273	27.42800292	60.63594376	317.0922784	25.650342825	188.86411108	25.650342825	188.86411108	0.135813748193456	0.003010	-1	7.36302482849954	0.003041	1	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0031093,platelet alpha granule lumen	GO:0048306,calcium-dependent protein binding;GO:0004866,endopeptidase inhibitor activity;GO:0019899,enzyme binding;GO:0019838,growth factor binding;GO:0019966,interleukin-1 binding;GO:0019959,interleukin-8 binding;GO:0002020,protease binding;GO:0004867,serine-type endopeptidase inhibitor activity;GO:0005102,signaling receptor binding;GO:0043120,tumor necrosis factor binding	GO:0022617,extracellular matrix disassembly;GO:2000267,negative regulation of blood coagulation, intrinsic pathway;GO:0001869,negative regulation of complement activation, lectin pathway;GO:0002576,platelet degranulation;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0048863,stem cell differentiation	hsa:2,path:hsa04610,Complement and coagulation cascades
BID_HUMAN	P55957	BID	BH3-interacting domain death agonist	0.371284125	0.082965574	0.060402091	2.55E-05	0.2271248495	0.0302137955	0.2271248495	0.0302137955	7.51725646319411	0.030876	1	0.133027256007054	0.030578	-1	GO:0005829,cytosol;GO:0032592,integral component of mitochondrial membrane;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion	GO:0005123,death receptor binding;GO:0031625,ubiquitin protein ligase binding	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0008637,apoptotic mitochondrial changes;GO:0090150,establishment of protein localization to membrane;GO:0008625,extrinsic apoptotic signaling pathway via death domain receptors;GO:0097284,hepatocyte apoptotic process;GO:0042775,mitochondrial ATP synthesis coupled electron transport;GO:0097345,mitochondrial outer membrane permeabilization;GO:0043066,negative regulation of apoptotic process;GO:1902230,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0051402,neuron apoptotic process;GO:0043065,positive regulation of apoptotic process;GO:2001238,positive regulation of extrinsic apoptotic signaling pathway;GO:2000271,positive regulation of fibroblast apoptotic process;GO:2001244,positive regulation of intrinsic apoptotic signaling pathway;GO:0010918,positive regulation of mitochondrial membrane potential;GO:1901030,positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:1900740,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0031334,positive regulation of protein-containing complex assembly;GO:0090200,positive regulation of release of cytochrome c from mitochondria;GO:0006626,protein targeting to mitochondrion;GO:0065003,protein-containing complex assembly;GO:0042981,regulation of apoptotic process;GO:0042127,regulation of cell population proliferation;GO:2000045,regulation of G1/S transition of mitotic cell cycle;GO:0001836,release of cytochrome c from mitochondria;GO:0042770,signal transduction in response to DNA damage	hsa:637,path:hsa04071,Sphingolipid signaling pathway;hsa:637,path:hsa04210,Apoptosis;hsa:637,path:hsa04215,Apoptosis - multiple species;hsa:637,path:hsa04217,Necroptosis;hsa:637,path:hsa04115,p53 signaling pathway;hsa:637,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:637,path:hsa05200,Pathways in cancer;hsa:637,path:hsa05010,Alzheimer disease;hsa:637,path:hsa05014,Amyotrophic lateral sclerosis (ALS);hsa:637,path:hsa05416,Viral myocarditis;hsa:637,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:637,path:hsa05152,Tuberculosis;hsa:637,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:637,path:hsa05162,Measles;hsa:637,path:hsa05164,Influenza A;hsa:637,path:hsa05161,Hepatitis B;hsa:637,path:hsa05160,Hepatitis C;hsa:637,path:hsa05168,Herpes simplex virus 1 infection;hsa:637,path:hsa05163,Human cytomegalovirus infection;hsa:637,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:637,path:hsa05169,Epstein-Barr virus infection;hsa:637,path:hsa01524,Platinum drug resistance
HSP74_HUMAN	P34932	HSPA4	Heat shock 70 kDa protein 4	6.824341192	3.814087772	8.235791787	5.991929872	5.319214482	7.1138608295	5.319214482	7.1138608295	0.747725406707719	0.444349	0	1.33738935581053	0.444502	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005737,cytoplasm	GO:0005524,ATP binding;GO:0016887,ATPase activity	GO:0051131,chaperone-mediated protein complex assembly;GO:0045040,protein insertion into mitochondrial outer membrane;GO:0006986,response to unfolded protein	hsa:3308,path:hsa04530,Tight junction;hsa:3308,path:hsa04612,Antigen processing and presentation
ERD21_HUMAN	P24390	KDELR1	ER lumen protein-retaining receptor 1	0.019882433	0.148557538	0.129117092	2.55E-05	0.0842199855	0.064571296	0.0842199855	0.064571296	1.30429448868426	0.347616	0	0.766698018488735	0.347246	0	GO:0005801,cis-Golgi network;GO:0030663,COPI-coated vesicle membrane;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0030133,transport vesicle	GO:0046923,ER retention sequence binding;GO:0005046,KDEL sequence binding	GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006621,protein retention in ER lumen;GO:0015031,protein transport;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0070231,T cell apoptotic process;GO:0030217,T cell differentiation	hsa:10945,path:hsa05110,Vibrio cholerae infection
HMGA1_HUMAN	P17096	HMGA1	High mobility group protein HMG-I/HMG-Y	0.45833548	2.55E-05	0.026700506	2.55E-05	0.22918049	0.013363003	0.22918049	0.013363003	17.15037331055	0.005184	1	0.0583077686935742	0.005098	-1	GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0090575,RNA polymerase II transcription regulator complex;GO:0035985,senescence-associated heterochromatin focus;GO:0005667,transcription regulator complex	GO:0051575,5'-deoxyribose-5-phosphate lyase activity;GO:0003682,chromatin binding;GO:0000987,cis-regulatory region sequence-specific DNA binding;GO:0003677,DNA binding;GO:0003906,DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0019899,enzyme binding;GO:0003680,minor groove of adenine-thymine-rich DNA binding;GO:0030374,nuclear receptor coactivator activity;GO:0042975,peroxisome proliferator activated receptor binding;GO:0042974,retinoic acid receptor binding;GO:0046965,retinoid X receptor binding;GO:0030527,structural constituent of chromatin;GO:0003713,transcription coactivator activity;GO:0003712,transcription coregulator activity;GO:0008134,transcription factor binding	GO:0006284,base-excision repair;GO:0006268,DNA unwinding involved in DNA replication;GO:0075713,establishment of integrated proviral latency;GO:0008285,negative regulation of cell population proliferation;GO:0031936,negative regulation of chromatin silencing;GO:0045892,negative regulation of transcription, DNA-templated;GO:0051169,nuclear transport;GO:0006337,nucleosome disassembly;GO:0090402,oncogene-induced cell senescence;GO:2000774,positive regulation of cellular senescence;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0006355,regulation of transcription, DNA-templated;GO:0009615,response to virus;GO:0035986,senescence-associated heterochromatin focus assembly	
CAMP_HUMAN	P49913	CAMP	Cathelicidin antimicrobial peptide	0.226269629	0.22095591	0.060919369	2.55E-05	0.2236127695	0.0304724345	0.2236127695	0.0304724345	7.33819838057245	0.032319	1	0.136273230585787	0.032013	-1	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0042581,specific granule;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen;GO:0042995,cell projection;GO:0005737,cytoplasm	GO:0001530,lipopolysaccharide binding	GO:0019731,antibacterial humoral response;GO:0019732,antifungal humoral response;GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0019730,antimicrobial humoral response;GO:0002544,chronic inflammatory response;GO:0051838,cytolysis by host of symbiont cells;GO:0042742,defense response to bacterium;GO:0050829,defense response to Gram-negative bacterium;GO:0050830,defense response to Gram-positive bacterium;GO:0045087,innate immune response;GO:0002227,innate immune response in mucosa;GO:0051873,killing by host of symbiont cells;GO:0035821,modulation of process of other organism;GO:0043312,neutrophil degranulation;GO:0032757,positive regulation of interleukin-8 production;GO:0001878,response to yeast;GO:0071347,cellular response to interleukin-1;GO:0071354,cellular response to interleukin-6;GO:0071222,cellular response to lipopolysaccharide;GO:0071224,cellular response to peptidoglycan;GO:0071356,cellular response to tumor necrosis factor;GO:0045766,positive regulation of angiogenesis;GO:0008284,positive regulation of cell population proliferation;GO:0001934,positive regulation of protein phosphorylation	hsa:820,path:hsa04621,NOD-like receptor signaling pathway;hsa:820,path:hsa04970,Salivary secretion;hsa:820,path:hsa05150,Staphylococcus aureus infection;hsa:820,path:hsa05152,Tuberculosis
RL28_HUMAN	P46779	RPL28	60S ribosomal protein L28	1.925682121	0.341721057	0.431877155	1.52325384	1.133701589	0.9775654975	1.133701589	0.9775654975	1.15971931486872	0.384860	0	0.862277610779639	0.384562	0	GO:0044297,cell body;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6158,path:hsa03010,Ribosome
HV428_HUMAN	A0A0C4DH34	IGHV4-28	Immunoglobulin heavy variable 4-28	0.082329474	0.002311159	0.033762264	0.003319734	0.0423203165	0.018540999	0.0423203165	0.018540999	2.28252622741633	0.193945	0	0.438111066584296	0.193381	0	GO:0009897,external side of plasma membrane;GO:0042571,immunoglobulin complex, circulating;GO:0005576,extracellular region;GO:0005886,plasma membrane	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006956,complement activation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response	
USP9X_HUMAN	Q93008	USP9X	Probable ubiquitin carboxyl-terminal hydrolase FAF-X	1.000466396	1.097662644	1.31519669	1.195165415	1.04906452	1.2551810525	1.04906452	1.2551810525	0.835787409243098	0.493356	0	1.19647650699311	0.493291	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030426,growth cone;GO:0016020,membrane;GO:0005634,nucleus	GO:0070410,co-SMAD binding;GO:0004197,cysteine-type endopeptidase activity;GO:0008234,cysteine-type peptidase activity;GO:0101005,deubiquitinase activity;GO:1990380,Lys48-specific deubiquitinase activity;GO:0004843,thiol-dependent deubiquitinase	GO:1990000,amyloid fibril formation;GO:0048675,axon extension;GO:0030509,BMP signaling pathway;GO:0007049,cell cycle;GO:0051301,cell division;GO:0016477,cell migration;GO:0007059,chromosome segregation;GO:0007292,female gamete generation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0001764,neuron migration;GO:1901537,positive regulation of DNA demethylation;GO:0016579,protein deubiquitination;GO:0071947,protein deubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0008104,protein localization;GO:0050821,protein stabilization;GO:0016567,protein ubiquitination;GO:0042752,regulation of circadian rhythm;GO:0048511,rhythmic process;GO:0007179,transforming growth factor beta receptor signaling pathway	
SIAE_HUMAN	Q9HAT2	SIAE	Sialate O-acetylesterase	0.216798979	0.399440109	0.320918384	0.034779294	0.308119544	0.177848839	0.308119544	0.177848839	1.7324799292055	0.264005	0	0.577207264074102	0.263503	0	GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005764,lysosome	GO:0106331,sialate 4-O-acetylesterase activity;GO:0106330,sialate 9-O-acetylesterase activity;GO:0001681,sialate O-acetylesterase activity	GO:0005975,carbohydrate metabolic process;GO:0002682,regulation of immune system process	
PSMG3_HUMAN	Q9BT73	PSMG3	Proteasome assembly chaperone 3	0.040612013	0.066529628	0.082474048	0.105448412	0.0535708205	0.09396123	0.0535708205	0.09396123	0.570137497135787	0.289673	0	1.75396286864787	0.289969	0	GO:0032991,protein-containing complex	GO:0060090,molecular adaptor activity;GO:0044877,protein-containing complex binding	GO:0051131,chaperone-mediated protein complex assembly	
XPO1_HUMAN	O14980	XPO1	Exportin-1	3.125606355	2.445797472	5.911371118	4.688450002	2.7857019135	5.29991056	2.7857019135	5.29991056	0.525613004590025	0.248695	0	1.90254044566495	0.249014	0	GO:0005642,annulate lamellae;GO:0015030,Cajal body;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043657,host cell;GO:0043231,intracellular membrane-bounded organelle;GO:0000776,kinetochore;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:1990904,ribonucleoprotein complex	GO:0005049,nuclear export signal receptor activity;GO:0003723,RNA binding;GO:0031267,small GTPase binding	GO:0075733,intracellular transport of virus;GO:0007052,mitotic spindle organization;GO:0051028,mRNA transport;GO:0006913,nucleocytoplasmic transport;GO:0006611,protein export from nucleus;GO:0043488,regulation of mRNA stability;GO:0032434,regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0000055,ribosomal large subunit export from nucleus;GO:0000056,ribosomal small subunit export from nucleus;GO:0000054,ribosomal subunit export from nucleus;GO:0042254,ribosome biogenesis;GO:0016032,viral process;GO:0006886,intracellular protein transport	hsa:7514,path:hsa03013,RNA transport;hsa:7514,path:hsa03008,Ribosome biogenesis in eukaryotes;hsa:7514,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:7514,path:hsa05164,Influenza A
4F2_HUMAN	P08195	SLC3A2	4F2 cell-surface antigen heavy chain	2.205911168	1.280669694	3.760083612	3.077149662	1.743290431	3.418616637	1.743290431	3.418616637	0.509940310981994	0.234268	0	1.96101382546968	0.234593	0	GO:1990184,amino acid transport complex;GO:0016324,apical plasma membrane;GO:0009925,basal plasma membrane;GO:0016323,basolateral plasma membrane;GO:0030054,cell junction;GO:0009986,cell surface;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005765,lysosomal membrane;GO:0042470,melanosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0044225,apical pole of neuron;GO:0045202,synapse	GO:0015173,aromatic amino acid transmembrane transporter activity;GO:0045296,cadherin binding;GO:0005432,calcium;GO:0003824,catalytic activity;GO:0003725,double-stranded RNA binding;GO:0015180,L-alanine transmembrane transporter activity;GO:0015190,L-leucine transmembrane transporter activity;GO:0015175,neutral amino acid transmembrane transporter activity;GO:0003723,RNA binding;GO:0016787,hydrolase activity	GO:0006865,amino acid transport;GO:0006816,calcium ion transport;GO:0005975,carbohydrate metabolic process;GO:1904273,L-alanine import across plasma membrane;GO:1902475,L-alpha-amino acid transmembrane transport;GO:1903801,L-leucine import across plasma membrane;GO:0098713,leucine import across plasma membrane;GO:0050900,leukocyte migration;GO:0015823,phenylalanine transport;GO:0043330,response to exogenous dsRNA;GO:0015827,tryptophan transport	hsa:6520,path:hsa04150,mTOR signaling pathway;hsa:6520,path:hsa04216,Ferroptosis;hsa:6520,path:hsa04974,Protein digestion and absorption
S10A4_HUMAN	P26447	S100A4	Protein S100-A4	2.544872923	10.20825688	2.200301322	3.889592884	6.3765649015	3.044947103	6.3765649015	3.044947103	2.09414636307395	0.214516	0	0.477521541776156	0.213965	0	GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043005,neuron projection;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm	GO:0003779,actin binding;GO:0005509,calcium ion binding;GO:0048306,calcium-dependent protein binding;GO:0042802,identical protein binding;GO:0050786,RAGE receptor binding;GO:0003723,RNA binding;GO:0046914,transition metal ion binding	GO:0001837,epithelial to mesenchymal transition;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling	
CALD1_HUMAN	Q05682	CALD1	Caldesmon	15.18217648	11.43409849	4.354494747	9.309531582	13.308137485	6.8320131645	13.308137485	6.8320131645	1.94790864194331	0.232746	0	0.513371098863426	0.232210	0	GO:0030478,actin cap;GO:0015629,actin cytoskeleton;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0030016,myofibril;GO:0005886,plasma membrane	GO:0003779,actin binding;GO:0045296,cadherin binding;GO:0005516,calmodulin binding;GO:0017022,myosin binding;GO:0005523,tropomyosin binding	GO:0051017,actin filament bundle assembly;GO:0001525,angiogenesis;GO:0006936,muscle contraction	hsa:800,path:hsa04270,Vascular smooth muscle contraction
GIPC1_HUMAN	O14908	GIPC1	PDZ domain-containing protein GIPC1	0.189558086	0.096833901	0.188706421	0.294616612	0.1431959935	0.2416615165	0.1431959935	0.2416615165	0.592547773323271	0.310151	0	1.6876276395261	0.310432	0	GO:0005903,brush border;GO:0005938,cell cortex;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0043198,dendritic shaft;GO:0043197,dendritic spine;GO:0030139,endocytic vesicle;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0016020,membrane;GO:0098685,Schaffer collateral - CA1 synapse;GO:0008021,synaptic vesicle;GO:0012506,vesicle membrane	GO:0003779,actin binding;GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0017022,myosin binding;GO:0030165,PDZ domain binding;GO:0005102,signaling receptor binding	GO:0098761,cellular response to interleukin-7;GO:0007268,chemical synaptic transmission;GO:0043542,endothelial cell migration;GO:0007186,G protein-coupled receptor signaling pathway;GO:0014047,glutamate secretion;GO:0032435,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032467,positive regulation of cytokinesis;GO:0048023,positive regulation of melanin biosynthetic process;GO:0030511,positive regulation of transforming growth factor beta receptor signaling pathway;GO:0006605,protein targeting;GO:0031647,regulation of protein stability;GO:0048167,regulation of synaptic plasticity;GO:2000300,regulation of synaptic vesicle exocytosis	
SYQ_HUMAN	P47897	QARS1	Glutamine--tRNA ligase	3.14367715	2.710985914	5.251862225	3.745083231	2.927331532	4.498472728	2.927331532	4.498472728	0.650738974981288	0.362321	0	1.53671447146493	0.362558	0	GO:0017101,aminoacyl-tRNA synthetase multienzyme complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005759,mitochondrial matrix;GO:0032991,protein-containing complex;GO:0016021,integral component of membrane	GO:0005524,ATP binding;GO:0004819,glutamine-tRNA ligase activity;GO:0019901,protein kinase binding;GO:0004860,protein kinase inhibitor activity;GO:0004812,aminoacyl-tRNA ligase activity	GO:0007420,brain development;GO:0006425,glutaminyl-tRNA aminoacylation;GO:2001234,negative regulation of apoptotic signaling pathway;GO:0006469,negative regulation of protein kinase activity;GO:0032873,negative regulation of stress-activated MAPK cascade;GO:0045892,negative regulation of transcription, DNA-templated;GO:0006418,tRNA aminoacylation for protein translation;GO:0006412,translation;GO:0043039,tRNA aminoacylation	hsa:5859,path:hsa00970,Aminoacyl-tRNA biosynthesis
AHNK_HUMAN	Q09666	AHNAK	Neuroblast differentiation-associated protein AHNAK	139.3299426	123.1811347	71.15576193	566.690374	131.25553865	318.923067965	131.25553865	318.923067965	0.411558622860121	0.146302	0	2.42978750645659	0.146632	0	GO:0015629,actin cytoskeleton;GO:0044291,cell-cell contact zone;GO:0043034,costamere;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005765,lysosomal membrane;GO:0016020,membrane;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0042383,sarcolemma;GO:0030315,T-tubule;GO:0031982,vesicle	GO:0045296,cadherin binding;GO:0042802,identical protein binding;GO:0003723,RNA binding;GO:0044548,S100 protein binding;GO:0097493,structural molecule activity conferring elasticity	GO:0043484,regulation of RNA splicing;GO:1901385,regulation of voltage-gated calcium channel activity	hsa:79026,path:hsa05132,Salmonella infection
PCBP2_HUMAN	Q15366	PCBP2	Poly(rC)-binding protein 2	3.112475955	10.68084859	4.036916912	2.953892868	6.8966622725	3.49540489	6.8966622725	3.49540489	1.97306534994863	0.229453	0	0.506825584882952	0.228914	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0014069,postsynaptic density	GO:1990829,C-rich single-stranded DNA binding;GO:0019899,enzyme binding;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0003697,single-stranded DNA binding;GO:0031625,ubiquitin protein ligase binding	GO:0051607,defense response to virus;GO:0045087,innate immune response;GO:0075522,IRES-dependent viral translational initiation;GO:0016071,mRNA metabolic process;GO:0000398,mRNA splicing, via spliceosome;GO:0050687,negative regulation of defense response to virus;GO:0032480,negative regulation of type I interferon production;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010468,regulation of gene expression;GO:0051252,regulation of RNA metabolic process;GO:0016070,RNA metabolic process;GO:0039694,viral RNA genome replication	hsa:5094,path:hsa04216,Ferroptosis
ZA2G_HUMAN	P25311	AZGP1	Zinc-alpha-2-glycoprotein	6.31321773	3.339281477	6.694363437	15.47203649	4.8262496035	11.0831999635	4.8262496035	11.0831999635	0.435456332051588	0.166980	0	2.29644151754241	0.167315	0	GO:0062023,collagen-containing extracellular matrix;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005634,nucleus	GO:0008320,protein transmembrane transporter activity;GO:0004540,ribonuclease activity	GO:0002476,antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0007155,cell adhesion;GO:0001580,detection of chemical stimulus involved in sensory perception of bitter taste;GO:0008285,negative regulation of cell population proliferation;GO:0001895,retina homeostasis;GO:0055085,transmembrane transport	
ACSF3_HUMAN	Q4G176	ACSF3	Malonate--CoA ligase ACSF3, mitochondrial	0.199686318	0.142819786	0.257513409	0.251975428	0.171253052	0.2547444185	0.171253052	0.2547444185	0.67225438346552	0.381116	0	1.48753213752944	0.381335	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0016878,acid-thiol ligase activity;GO:0005524,ATP binding;GO:0016405,CoA-ligase activity;GO:0090409,malonyl-CoA synthetase activity;GO:0031957,very long-chain fatty acid-CoA ligase activity;GO:0000166,nucleotide binding	GO:0006633,fatty acid biosynthetic process;GO:0006631,fatty acid metabolic process;GO:0035338,long-chain fatty-acyl-CoA biosynthetic process;GO:0090410,malonate catabolic process	hsa:197322,path:hsa00061,Fatty acid biosynthesis;hsa:197322,path:hsa00280,Valine, leucine and isoleucine degradation
AMRP_HUMAN	P30533	LRPAP1	Alpha-2-macroglobulin receptor-associated protein	0.21985796	0.616144792	0.319012748	0.175763478	0.418001376	0.247388113	0.418001376	0.247388113	1.68965829008931	0.270947	0	0.591835642665444	0.270454	0	GO:0009986,cell surface;GO:0005801,cis-Golgi network;GO:0012505,endomembrane system;GO:0005783,endoplasmic reticulum;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0005768,endosome;GO:0031904,endosome lumen;GO:0005576,extracellular region;GO:0005794,Golgi apparatus;GO:0005796,Golgi lumen;GO:0005886,plasma membrane;GO:0048237,rough endoplasmic reticulum lumen	GO:0001540,amyloid-beta binding;GO:0008201,heparin binding;GO:0035473,lipase binding;GO:0050750,low-density lipoprotein particle receptor binding;GO:0048019,receptor antagonist activity;GO:0048018,receptor ligand activity;GO:0005102,signaling receptor binding;GO:0070326,very-low-density lipoprotein particle receptor binding	GO:0150093,amyloid-beta clearance by transcytosis;GO:1900116,extracellular negative regulation of signal transduction;GO:1900222,negative regulation of amyloid-beta clearance;GO:0060548,negative regulation of cell death;GO:0032091,negative regulation of protein binding;GO:0002091,negative regulation of receptor internalization;GO:0010916,negative regulation of very-low-density lipoprotein particle clearance;GO:1900223,positive regulation of amyloid-beta clearance;GO:0048259,regulation of receptor-mediated endocytosis;GO:0007165,signal transduction	hsa:4043,path:hsa04979,Cholesterol metabolism
DYN1_HUMAN	Q05193	DNM1	Dynamin-1	0.069954138	0.072097332	0.07523123	2.55E-05	0.071025735	0.037628365	0.071025735	0.037628365	1.88755836189003	0.240932	0	0.529784943443387	0.240404	0	GO:0030424,axon;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0044327,dendritic spine head;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005874,microtubule;GO:0015630,microtubule cytoskeleton;GO:0031966,mitochondrial membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0098844,postsynaptic endocytic zone membrane;GO:0098793,presynapse;GO:0098978,glutamatergic synapse;GO:0005794,Golgi apparatus;GO:0030117,membrane coat;GO:0001917,photoreceptor inner segment;GO:0098684,photoreceptor ribbon synapse;GO:0098835,presynaptic endocytic zone membrane;GO:0008021,synaptic vesicle;GO:0043196,varicosity	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0008017,microtubule binding;GO:0019901,protein kinase binding;GO:0003723,RNA binding;GO:0031749,D2 dopamine receptor binding;GO:0050998,nitric-oxide synthase binding;GO:0008022,protein C-terminus binding;GO:0044877,protein-containing complex binding;GO:0017124,SH3 domain binding	GO:0003374,dynamin family protein polymerization involved in mitochondrial fission;GO:0006897,endocytosis;GO:0007032,endosome organization;GO:0048013,ephrin receptor signaling pathway;GO:0061025,membrane fusion;GO:0000266,mitochondrial fission;GO:0098884,postsynaptic neurotransmitter receptor internalization;GO:0031623,receptor internalization;GO:0006898,receptor-mediated endocytosis;GO:0050803,regulation of synapse structure or activity;GO:0016185,synaptic vesicle budding from presynaptic endocytic zone membrane;GO:0002031,G protein-coupled receptor internalization;GO:0050804,modulation of chemical synaptic transmission;GO:1900244,positive regulation of synaptic vesicle endocytosis;GO:1904645,response to amyloid-beta;GO:1901998,toxin transport	hsa:1759,path:hsa04072,Phospholipase D signaling pathway;hsa:1759,path:hsa04144,Endocytosis;hsa:1759,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:1759,path:hsa04721,Synaptic vesicle cycle;hsa:1759,path:hsa05100,Bacterial invasion of epithelial cells
PKHO2_HUMAN	Q8TD55	PLEKHO2	Pleckstrin homology domain-containing family O member 2	0.464731863	0.260783744	0.630281281	0.689435974	0.3627578035	0.6598586275	0.3627578035	0.6598586275	0.549750792642322	0.270935	0	1.8190060176059	0.271243	0	GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen		GO:0071888,macrophage apoptotic process;GO:0043312,neutrophil degranulation	
IL16_HUMAN	Q14005	IL16	Pro-interleukin-16	0.736049908	0.371694006	1.649090641	0.937116043	0.553871957	1.293103342	0.553871957	1.293103342	0.428327681949491	0.160747	0	2.33466115346223	0.161081	0	GO:0005829,cytosol;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0090543,Flemming body;GO:0005925,focal adhesion;GO:0016607,nuclear speck;GO:0005886,plasma membrane	GO:0042609,CD4 receptor binding;GO:0005125,cytokine activity	GO:0019221,cytokine-mediated signaling pathway;GO:0006955,immune response;GO:0050930,induction of positive chemotaxis;GO:0030595,leukocyte chemotaxis;GO:0050729,positive regulation of inflammatory response;GO:0032730,positive regulation of interleukin-1 alpha production;GO:0032735,positive regulation of interleukin-12 production;GO:0032755,positive regulation of interleukin-6 production;GO:1902565,positive regulation of neutrophil activation;GO:0051924,regulation of calcium ion transport;GO:0016032,viral process;GO:0006935,chemotaxis	hsa:3603,path:hsa04060,Cytokine-cytokine receptor interaction
CATS_HUMAN	P25774	CTSS	Cathepsin S	1.283635603	1.829615321	2.953233936	1.001842719	1.556625462	1.9775383275	1.556625462	1.9775383275	0.787153118780703	0.475512	0	1.27040086120601	0.475630	0	GO:0062023,collagen-containing extracellular matrix;GO:0036021,endolysosome lumen;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0043231,intracellular membrane-bounded organelle;GO:0005770,late endosome;GO:0043202,lysosomal lumen;GO:0005764,lysosome;GO:0045335,phagocytic vesicle;GO:1904724,tertiary granule lumen	GO:0005518,collagen binding;GO:0004197,cysteine-type endopeptidase activity;GO:0001968,fibronectin binding;GO:0043236,laminin binding;GO:0043394,proteoglycan binding;GO:0008234,cysteine-type peptidase activity	GO:0002250,adaptive immune response;GO:0019882,antigen processing and presentation;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0048002,antigen processing and presentation of peptide antigen;GO:0034769,basement membrane disassembly;GO:0097067,cellular response to thyroid hormone stimulus;GO:0030574,collagen catabolic process;GO:0022617,extracellular matrix disassembly;GO:0006955,immune response;GO:0043312,neutrophil degranulation;GO:2001259,positive regulation of cation channel activity;GO:0016485,protein processing;GO:0006508,proteolysis;GO:0051603,proteolysis involved in cellular protein catabolic process;GO:0010447,response to acidic pH;GO:0002224,toll-like receptor signaling pathway	hsa:1520,path:hsa04145,Phagosome;hsa:1520,path:hsa04142,Lysosome;hsa:1520,path:hsa04210,Apoptosis;hsa:1520,path:hsa04612,Antigen processing and presentation;hsa:1520,path:hsa05152,Tuberculosis
PDXD1_HUMAN	Q6P996	PDXDC1	Pyridoxal-dependent decarboxylase domain-containing protein 1	1.573112082	0.89575766	1.537368622	0.880521913	1.234434871	1.2089452675	1.234434871	1.2089452675	1.02108416665769	0.426444	0	0.979351196163674	0.426232	0	GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle	GO:0045296,cadherin binding;GO:0016831,carboxy-lyase activity;GO:0030170,pyridoxal phosphate binding;GO:0008117,sphinganine-1-phosphate aldolase activity	GO:0001667,ameboidal-type cell migration;GO:0019752,carboxylic acid metabolic process;GO:0030149,sphingolipid catabolic process	
TBA1A_HUMAN	Q71U36	TUBA1A	Tubulin alpha-1A chain	139.9473091	197.6666114	164.2070591	159.5898187	168.80696025	161.8984389	168.80696025	161.8984389	1.04267194543035	0.419541	0	0.959074428330629	0.419314	0	GO:0005737,cytoplasm;GO:0005881,cytoplasmic microtubule;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0045121,membrane raft;GO:0005874,microtubule;GO:0015630,microtubule cytoskeleton;GO:0043209,myelin sheath;GO:0031594,neuromuscular junction;GO:0005634,nucleus;GO:0055037,recycling endosome	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0019904,protein domain specific binding;GO:0005200,structural constituent of cytoskeleton;GO:0005198,structural molecule activity	GO:0051301,cell division;GO:0097711,ciliary basal body-plasma membrane docking;GO:0030705,cytoskeleton-dependent intracellular transport;GO:0000086,G2/M transition of mitotic cell cycle;GO:0000226,microtubule cytoskeleton organization;GO:0007017,microtubule-based process;GO:0000278,mitotic cell cycle;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0050807,regulation of synapse organization	hsa:7846,path:hsa04145,Phagosome;hsa:7846,path:hsa04210,Apoptosis;hsa:7846,path:hsa04530,Tight junction;hsa:7846,path:hsa04540,Gap junction;hsa:7846,path:hsa05130,Pathogenic Escherichia coli infection
ERF3A_HUMAN	P15170	GSPT1	Eukaryotic peptide chain release factor GTP-binding subunit ERF3A	0.957572102	1.000103985	1.589161008	1.020815641	0.9788380435	1.3049883245	0.9788380435	1.3049883245	0.750074177004639	0.446243	0	1.33320147614389	0.446394	0	GO:0005829,cytosol;GO:0018444,translation release factor complex	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0003723,RNA binding;GO:0003747,translation release factor activity	GO:0002184,cytoplasmic translational termination;GO:0000082,G1/S transition of mitotic cell cycle;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006479,protein methylation;GO:0006449,regulation of translational termination;GO:0006412,translation	hsa:2935,path:hsa03015,mRNA surveillance pathway
EZRI_HUMAN	P15311	EZR	Ezrin	17.70815996	8.948280456	18.47111533	30.73973336	13.328220208	24.605424345	13.328220208	24.605424345	0.541678128412705	0.263500	0	1.84611478209454	0.263811	0	GO:0015629,actin cytoskeleton;GO:0005884,actin filament;GO:0045177,apical part of cell;GO:0016324,apical plasma membrane;GO:0097449,astrocyte projection;GO:0016323,basolateral plasma membrane;GO:0005903,brush border;GO:0044297,cell body;GO:0071944,cell periphery;GO:0042995,cell projection;GO:0051286,cell tip;GO:0036064,ciliary basal body;GO:0030863,cortical cytoskeleton;GO:0005737,cytoplasm;GO:0098592,cytoplasmic side of apical plasma membrane;GO:0005829,cytosol;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0019898,extrinsic component of membrane;GO:0001650,fibrillar center;GO:0030175,filopodium;GO:0005925,focal adhesion;GO:0001772,immunological synapse;GO:0016020,membrane;GO:0044393,microspike;GO:0005902,microvillus;GO:0031528,microvillus membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0044853,plasma membrane raft;GO:0032991,protein-containing complex;GO:0001726,ruffle;GO:0032587,ruffle membrane;GO:0097454,Schwann cell microvillus;GO:0030315,T-tubule;GO:0001931,uropod;GO:0031982,vesicle;GO:0005856,cytoskeleton	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0051117,ATPase binding;GO:0045296,cadherin binding;GO:0050839,cell adhesion molecule binding;GO:0097718,disordered domain specific binding;GO:0042802,identical protein binding;GO:0008017,microtubule binding;GO:0008022,protein C-terminus binding;GO:0019904,protein domain specific binding;GO:0051018,protein kinase A binding;GO:0034236,protein kinase A catalytic subunit binding;GO:0034237,protein kinase A regulatory subunit binding;GO:0003723,RNA binding;GO:0044548,S100 protein binding	GO:0031532,actin cytoskeleton reorganization;GO:0051017,actin filament bundle assembly;GO:0030953,astral microtubule organization;GO:0007411,axon guidance;GO:0034629,cellular protein-containing complex localization;GO:0071320,cellular response to cAMP;GO:0043622,cortical microtubule organization;GO:0051660,establishment of centrosome localization;GO:0061028,establishment of endothelial barrier;GO:0035088,establishment or maintenance of apical/basal cell polarity;GO:0046847,filopodium assembly;GO:0001951,intestinal D-glucose absorption;GO:0007159,leukocyte cell-cell adhesion;GO:0022614,membrane to membrane docking;GO:0030033,microvillus assembly;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:0032703,negative regulation of interleukin-2 production;GO:1903753,negative regulation of p38MAPK cascade;GO:0050860,negative regulation of T cell receptor signaling pathway;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0048015,phosphatidylinositol-mediated signaling;GO:1903364,positive regulation of cellular protein catabolic process;GO:2000643,positive regulation of early endosome to late endosome transport;GO:0010628,positive regulation of gene expression;GO:0040018,positive regulation of multicellular organism growth;GO:1902966,positive regulation of protein localization to early endosome;GO:1903078,positive regulation of protein localization to plasma membrane;GO:0050714,positive regulation of protein secretion;GO:0010737,protein kinase A signaling;GO:0072697,protein localization to cell cortex;GO:0072659,protein localization to plasma membrane;GO:0031623,receptor internalization;GO:0008360,regulation of cell shape;GO:0032532,regulation of microvillus length;GO:1902115,regulation of organelle assembly;GO:0003376,sphingosine-1-phosphate receptor signaling pathway;GO:1902896,terminal web assembly	hsa:7430,path:hsa04530,Tight junction;hsa:7430,path:hsa04810,Regulation of actin cytoskeleton;hsa:7430,path:hsa04670,Leukocyte transendothelial migration;hsa:7430,path:hsa04971,Gastric acid secretion;hsa:7430,path:hsa05206,MicroRNAs in cancer;hsa:7430,path:hsa05205,Proteoglycans in cancer;hsa:7430,path:hsa05130,Pathogenic Escherichia coli infection
XPO5_HUMAN	Q9HAV4	XPO5	Exportin-5	1.084902625	1.026593196	0.874027341	1.170228897	1.0557479105	1.022128119	1.0557479105	1.022128119	1.03289195441849	0.422647	0	0.968155474270294	0.422427	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016442,RISC complex;GO:0042565,RNA nuclear export complex	GO:0003729,mRNA binding;GO:0005049,nuclear export signal receptor activity;GO:0070883,pre-miRNA binding;GO:1905172,RISC complex binding;GO:0003723,RNA binding;GO:0031267,small GTPase binding;GO:0000049,tRNA binding	GO:0010586,miRNA metabolic process;GO:1900370,positive regulation of RNA interference;GO:0035281,pre-miRNA export from nucleus;GO:0006611,protein export from nucleus;GO:0006405,RNA export from nucleus;GO:0016032,viral process;GO:0051168,nuclear export	hsa:57510,path:hsa03013,RNA transport
TR150_HUMAN	Q9Y2W1	THRAP3	Thyroid hormone receptor-associated protein 3	0.946566412	1.207052866	1.029694898	0.250536931	1.076809639	0.6401159145	1.076809639	0.6401159145	1.68221038503801	0.272181	0	0.594455966325168	0.271690	0	GO:0070062,extracellular exosome;GO:0016592,mediator complex;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0003677,DNA binding;GO:0030374,nuclear receptor coactivator activity;GO:0051219,phosphoprotein binding;GO:0003723,RNA binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0046966,thyroid hormone receptor binding;GO:0003713,transcription coactivator activity;GO:0003712,transcription coregulator activity;GO:0042809,vitamin D receptor binding	GO:0006397,mRNA processing;GO:0048255,mRNA stabilization;GO:0000956,nuclear-transcribed mRNA catabolic process;GO:0042753,positive regulation of circadian rhythm;GO:0048026,positive regulation of mRNA splicing, via spliceosome;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0048511,rhythmic process;GO:0008380,RNA splicing	
IGLL1_HUMAN	P15814	IGLL1	Immunoglobulin lambda-like polypeptide 1	0.228750492	0.108441109	0.331400124	0.543337274	0.1685958005	0.437368699	0.1685958005	0.437368699	0.385477517905322	0.124563	0	2.59418501352292	0.124882	0	GO:0005783,endoplasmic reticulum;GO:0009897,external side of plasma membrane;GO:0005576,extracellular region;GO:0042571,immunoglobulin complex, circulating;GO:0016020,membrane	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0006955,immune response;GO:0045087,innate immune response;GO:0050900,leukocyte migration;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation	hsa:3543,path:hsa05340,Primary immunodeficiency
HSP7C_HUMAN	P11142	HSPA8	Heat shock cognate 71 kDa protein	97.20892694	85.99797213	96.17455337	101.3580268	91.603449535	98.766290085	91.603449535	98.766290085	0.927476869447708	0.458429	0	1.07819400455289	0.458287	0	GO:0005776,autophagosome;GO:0072562,blood microparticle;GO:0101031,chaperone complex;GO:0061202,clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0098690,glycinergic synapse;GO:0005770,late endosome;GO:0098575,lumenal side of lysosomal membrane;GO:0043202,lysosomal lumen;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0042470,melanosome;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0098684,photoreceptor ribbon synapse;GO:0005886,plasma membrane;GO:0099524,postsynaptic cytosol;GO:0099634,postsynaptic specialization membrane;GO:0099523,presynaptic cytosol;GO:0000974,Prp19 complex;GO:1990904,ribonucleoprotein complex;GO:0034774,secretory granule lumen;GO:0005681,spliceosomal complex;GO:0043195,terminal bouton	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0055131,C3HC4-type RING finger domain binding;GO:0045296,cadherin binding;GO:0051087,chaperone binding;GO:1990833,clathrin-uncoating ATPase activity;GO:0019899,enzyme binding;GO:0001664,G protein-coupled receptor binding;GO:0031072,heat shock protein binding;GO:0023026,MHC class II protein complex binding;GO:0051787,misfolded protein binding;GO:0001786,phosphatidylserine binding;GO:0044183,protein folding chaperone;GO:0030674,protein-macromolecule adaptor activity;GO:0003723,RNA binding;GO:0031625,ubiquitin protein ligase binding;GO:0051082,unfolded protein binding	GO:0046034,ATP metabolic process;GO:0009267,cellular response to starvation;GO:0034620,cellular response to unfolded protein;GO:0051085,chaperone cofactor-dependent protein refolding;GO:0061684,chaperone-mediated autophagy;GO:1904764,chaperone-mediated autophagy translocation complex disassembly;GO:0061741,chaperone-mediated protein transport involved in chaperone-mediated autophagy;GO:0019221,cytokine-mediated signaling pathway;GO:0061738,late endosomal microautophagy;GO:0061024,membrane organization;GO:0000398,mRNA splicing, via spliceosome;GO:1902904,negative regulation of supramolecular fiber organization;GO:0045892,negative regulation of transcription, DNA-templated;GO:0007269,neurotransmitter secretion;GO:0043312,neutrophil degranulation;GO:0044829,positive regulation by host of viral genome replication;GO:0048026,positive regulation of mRNA splicing, via spliceosome;GO:0006892,post-Golgi vesicle-mediated transport;GO:0006457,protein folding;GO:0042026,protein refolding;GO:0061740,protein targeting to lysosome involved in chaperone-mediated autophagy;GO:0051726,regulation of cell cycle;GO:1900034,regulation of cellular response to heat;GO:0043488,regulation of mRNA stability;GO:0099175,regulation of postsynapse organization;GO:0061635,regulation of protein complex stability;GO:1904589,regulation of protein import;GO:0031647,regulation of protein stability;GO:0043254,regulation of protein-containing complex assembly;GO:0006986,response to unfolded protein;GO:1990832,slow axonal transport;GO:0016192,vesicle-mediated transport;GO:0016032,viral process	hsa:3312,path:hsa03040,Spliceosome;hsa:3312,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:3312,path:hsa04010,MAPK signaling pathway;hsa:3312,path:hsa04144,Endocytosis;hsa:3312,path:hsa04612,Antigen processing and presentation;hsa:3312,path:hsa04915,Estrogen signaling pathway;hsa:3312,path:hsa04213,Longevity regulating pathway - multiple species;hsa:3312,path:hsa05134,Legionellosis;hsa:3312,path:hsa05162,Measles;hsa:3312,path:hsa05145,Toxoplasmosis
GDIR2_HUMAN	P52566	ARHGDIB	Rho GDP-dissociation inhibitor 2	7.245064843	40.10589175	8.83891327	5.277219975	23.6754782965	7.0580666225	23.6754782965	7.0580666225	3.35438577768965	0.117429	0	0.29811717145091	0.116882	0	GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane	GO:0005096,GTPase activator activity;GO:0003924,GTPase activity;GO:0005094,Rho GDP-dissociation inhibitor activity;GO:0031267,small GTPase binding	GO:0071461,cellular response to redox state;GO:0007275,multicellular organism development;GO:0007162,negative regulation of cell adhesion;GO:1901164,negative regulation of trophoblast cell migration;GO:0043547,positive regulation of GTPase activity;GO:2000249,regulation of actin cytoskeleton reorganization;GO:0035023,regulation of Rho protein signal transduction;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0007266,Rho protein signal transduction	hsa:397,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:397,path:hsa04722,Neurotrophin signaling pathway
TAGL_HUMAN	Q01995	TAGLN	Transgelin	94.45102411	114.0704112	21.01802431	11.30323795	104.260717655	16.16063113	104.260717655	16.16063113	6.45152511781884	0.040999	1	0.1550021090731	0.040647	-1	GO:0005737,cytoplasm	GO:0051015,actin filament binding	GO:0030855,epithelial cell differentiation;GO:0007517,muscle organ development	
FBLN5_HUMAN	Q9UBX5	FBLN5	Fibulin-5	0.46753879	1.131023825	1.663636958	8.326203295	0.7992813075	4.9949201265	0.7992813075	4.9949201265	0.160018836589498	0.006279	-1	6.24926428233779	0.006334	1	GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0005509,calcium ion binding;GO:0005178,integrin binding;GO:0008022,protein C-terminus binding;GO:0042803,protein homodimerization activity	GO:0007160,cell-matrix adhesion;GO:0048251,elastic fiber assembly;GO:0030198,extracellular matrix organization;GO:0034394,protein localization to cell surface;GO:2000121,regulation of removal of superoxide radicals;GO:0046903,secretion;GO:0001558,regulation of cell growth	
HDAC1_HUMAN	Q13547	HDAC1	Histone deacetylase 1	0.071221954	0.047504766	0.16414473	0.140694104	0.05936336	0.152419417	0.05936336	0.152419417	0.389473737456954	0.127829	0	2.56756721654569	0.128150	0	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0000792,heterochromatin;GO:0000118,histone deacetylase complex;GO:0043025,neuronal cell body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016581,NuRD complex;GO:0032991,protein-containing complex;GO:0016580,Sin3 complex	GO:0033613,activating transcription factor binding;GO:0001046,core promoter sequence-specific DNA binding;GO:0019213,deacetylase activity;GO:0070888,E-box binding;GO:0019899,enzyme binding;GO:0004407,histone deacetylase activity;GO:0042826,histone deacetylase binding;GO:0035851,Krueppel-associated box domain binding;GO:0032041,NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0051059,NF-kappaB binding;GO:0002039,p53 binding;GO:1990841,promoter-specific chromatin binding;GO:0033558,protein deacetylase activity;GO:0047485,protein N-terminus binding;GO:0070491,repressing transcription factor binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000979,RNA polymerase II core promoter sequence-specific DNA binding;GO:0001103,RNA polymerase II repressing transcription factor binding;GO:0001085,RNA polymerase II transcription factor binding;GO:0003714,transcription corepressor activity;GO:0008134,transcription factor binding	GO:0043044,ATP-dependent chromatin remodeling;GO:1904837,beta-catenin-TCF complex assembly;GO:0007596,blood coagulation;GO:0006325,chromatin organization;GO:0006338,chromatin remodeling;GO:0032922,circadian regulation of gene expression;GO:0006346,DNA methylation-dependent heterochromatin assembly;GO:0042733,embryonic digit morphogenesis;GO:0007492,endoderm development;GO:0009913,epidermal cell differentiation;GO:0061029,eyelid development in camera-type eye;GO:0061198,fungiform papilla formation;GO:0060789,hair follicle placode formation;GO:0021766,hippocampus development;GO:0016575,histone deacetylation;GO:0070932,histone H3 deacetylation;GO:0070933,histone H4 deacetylation;GO:0043922,negative regulation by host of viral transcription;GO:0060766,negative regulation of androgen receptor signaling pathway;GO:0043066,negative regulation of apoptotic process;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010629,negative regulation of gene expression;GO:0043124,negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:2001243,negative regulation of intrinsic apoptotic signaling pathway;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0030182,neuron differentiation;GO:0042475,odontogenesis of dentin-containing tooth;GO:0008284,positive regulation of cell population proliferation;GO:0048714,positive regulation of oligodendrocyte differentiation;GO:2000273,positive regulation of signaling receptor activity;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0006476,protein deacetylation;GO:1900221,regulation of amyloid-beta clearance;GO:0052548,regulation of endopeptidase activity;GO:0045652,regulation of megakaryocyte differentiation;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0006357,regulation of transcription by RNA polymerase II;GO:0006367,transcription initiation from RNA polymerase II promoter	hsa:3065,path:hsa04330,Notch signaling pathway;hsa:3065,path:hsa04110,Cell cycle;hsa:3065,path:hsa04919,Thyroid hormone signaling pathway;hsa:3065,path:hsa04213,Longevity regulating pathway - multiple species;hsa:3065,path:hsa05200,Pathways in cancer;hsa:3065,path:hsa05202,Transcriptional misregulation in cancer;hsa:3065,path:hsa05206,MicroRNAs in cancer;hsa:3065,path:hsa05203,Viral carcinogenesis;hsa:3065,path:hsa05220,Chronic myeloid leukemia;hsa:3065,path:hsa05016,Huntington disease;hsa:3065,path:hsa05031,Amphetamine addiction;hsa:3065,path:hsa05034,Alcoholism;hsa:3065,path:hsa05169,Epstein-Barr virus infection;hsa:3065,path:hsa05165,Human papillomavirus infection
NU1M_HUMAN	P03886	MT-ND1	NADH-ubiquinone oxidoreductase chain 1	0.070620693	0.015386818	0.127533761	0.254376916	0.0430037555	0.1909553385	0.0430037555	0.1909553385	0.225203211587614	0.024199	-1	4.44043401046683	0.024341	1	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0005750,mitochondrial respiratory chain complex III;GO:0005751,mitochondrial respiratory chain complex IV;GO:0045277,respiratory chain complex IV;GO:0005739,mitochondrion;GO:0005753,mitochondrial proton-transporting ATP synthase complex;GO:0045263,proton-transporting ATP synthase complex, coupling factor F(o);GO:0000276,mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0031305,integral component of mitochondrial inner membrane;GO:0016020,membrane;GO:0005615,extracellular space;GO:0014069,postsynaptic density;GO:0070469,respirasome;GO:0005576,extracellular region;GO:0048471,perinuclear region of cytoplasm;GO:0030425,dendrite;GO:0031966,mitochondrial membrane;GO:0043025,neuronal cell body;GO:0043005,neuron projection	GO:0008137,NADH dehydrogenase (ubiquinone) activity;GO:0048039,ubiquinone binding;GO:0004129,cytochrome-c oxidase activity;GO:0020037,heme binding;GO:0046872,metal ion binding;GO:0009055,electron transfer activity;GO:0015453,oxidoreduction-driven active transmembrane transporter activity;GO:0015078,proton transmembrane transporter activity;GO:0044877,protein-containing complex binding;GO:0008121,ubiquinol-cytochrome-c reductase activity;GO:0005507,copper ion binding;GO:0035255,ionotropic glutamate receptor binding;GO:0019901,protein kinase binding;GO:0048019,receptor antagonist activity;GO:0005102,signaling receptor binding;GO:0003954,NADH dehydrogenase activity	GO:0009060,aerobic respiration;GO:0007568,aging;GO:0021549,cerebellum development;GO:0015990,electron transport coupled proton transport;GO:0001701,in utero embryonic development;GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0045471,response to ethanol;GO:0001666,response to hypoxia;GO:0035094,response to nicotine;GO:0006123,mitochondrial electron transport, cytochrome c to oxygen;GO:0022904,respiratory electron transport chain;GO:0046688,response to copper ion;GO:0051602,response to electrical stimulus;GO:0006979,response to oxidative stress;GO:0008535,respiratory chain complex IV assembly;GO:0006754,ATP biosynthetic process;GO:0015986,ATP synthesis coupled proton transport;GO:0042407,cristae formation;GO:0042776,mitochondrial ATP synthesis coupled proton transport;GO:0055093,response to hyperoxia;GO:0031100,animal organ regeneration;GO:0042538,hyperosmotic salinity response;GO:0006122,mitochondrial electron transport, ubiquinol to cytochrome c;GO:0046686,response to cadmium ion;GO:0051592,response to calcium ion;GO:0033590,response to cobalamin;GO:0042493,response to drug;GO:0033762,response to glucagon;GO:0009408,response to heat;GO:0046689,response to mercury ion;GO:0009636,response to toxic substance;GO:0042773,ATP synthesis coupled electron transport;GO:0007595,lactation;GO:2001171,positive regulation of ATP biosynthetic process;GO:0010729,positive regulation of hydrogen peroxide biosynthetic process;GO:0010940,positive regulation of necrotic cell death;GO:0009409,response to cold;GO:0032147,activation of protein kinase activity;GO:0072522,purine-containing compound biosynthetic process;GO:0043610,regulation of carbohydrate utilization;GO:0072593,reactive oxygen species metabolic process;GO:0042220,response to cocaine;GO:0042542,response to hydrogen peroxide;GO:0006915,apoptotic process;GO:0006879,cellular iron ion homeostasis;GO:0007186,G protein-coupled receptor signaling pathway;GO:0030595,leukocyte chemotaxis;GO:0043066,negative regulation of apoptotic process;GO:1900118,negative regulation of execution phase of apoptosis;GO:0033194,response to hydroperoxide;GO:0014070,response to organic cyclic compound;GO:0071385,cellular response to glucocorticoid stimulus;GO:0009642,response to light intensity;GO:0010243,response to organonitrogen compound	hsa:4538,path:hsa00190,Oxidative phosphorylation;hsa:4538,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4538,path:hsa04714,Thermogenesis;hsa:4538,path:hsa05012,Parkinson disease;hsa:4512,path:hsa00190,Oxidative phosphorylation;hsa:4512,path:hsa04260,Cardiac muscle contraction;hsa:4512,path:hsa04714,Thermogenesis;hsa:4512,path:hsa05010,Alzheimer disease;hsa:4512,path:hsa05012,Parkinson disease;hsa:4512,path:hsa05016,Huntington disease;hsa:4512,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4514,path:hsa00190,Oxidative phosphorylation;hsa:4514,path:hsa04260,Cardiac muscle contraction;hsa:4514,path:hsa04714,Thermogenesis;hsa:4514,path:hsa05010,Alzheimer disease;hsa:4514,path:hsa05012,Parkinson disease;hsa:4514,path:hsa05016,Huntington disease;hsa:4514,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4508,path:hsa00190,Oxidative phosphorylation;hsa:4508,path:hsa04714,Thermogenesis;hsa:4508,path:hsa05010,Alzheimer disease;hsa:4508,path:hsa05012,Parkinson disease;hsa:4508,path:hsa05016,Huntington disease;hsa:4509,path:hsa00190,Oxidative phosphorylation;hsa:4509,path:hsa04714,Thermogenesis;hsa:4509,path:hsa05010,Alzheimer disease;hsa:4509,path:hsa05012,Parkinson disease;hsa:4509,path:hsa05016,Huntington disease;hsa:4519,path:hsa00190,Oxidative phosphorylation;hsa:4519,path:hsa04260,Cardiac muscle contraction;hsa:4519,path:hsa04714,Thermogenesis;hsa:4519,path:hsa05010,Alzheimer disease;hsa:4519,path:hsa05012,Parkinson disease;hsa:4519,path:hsa05016,Huntington disease;hsa:4519,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4513,path:hsa00190,Oxidative phosphorylation;hsa:4513,path:hsa04260,Cardiac muscle contraction;hsa:4513,path:hsa04714,Thermogenesis;hsa:4513,path:hsa05010,Alzheimer disease;hsa:4513,path:hsa05012,Parkinson disease;hsa:4513,path:hsa05016,Huntington disease;hsa:4513,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4536,path:hsa00190,Oxidative phosphorylation;hsa:4536,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4536,path:hsa04714,Thermogenesis;hsa:4536,path:hsa05012,Parkinson disease;hsa:4541,path:hsa00190,Oxidative phosphorylation;hsa:4541,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4541,path:hsa04714,Thermogenesis;hsa:4541,path:hsa05012,Parkinson disease;hsa:4539,path:hsa00190,Oxidative phosphorylation;hsa:4539,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4539,path:hsa04714,Thermogenesis;hsa:4539,path:hsa05012,Parkinson disease;hsa:4535,path:hsa00190,Oxidative phosphorylation;hsa:4535,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4535,path:hsa04714,Thermogenesis;hsa:4535,path:hsa05012,Parkinson disease;hsa:4537,path:hsa00190,Oxidative phosphorylation;hsa:4537,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4537,path:hsa04714,Thermogenesis;hsa:4537,path:hsa05012,Parkinson disease;hsa:4540,path:hsa00190,Oxidative phosphorylation;hsa:4540,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4540,path:hsa04714,Thermogenesis;hsa:4540,path:hsa05012,Parkinson disease
RISC_HUMAN	Q9HB40	SCPEP1	Retinoid-inducible serine carboxypeptidase	1.089104294	8.403897026	1.911952773	0.44038798	4.74650066	1.1761703765	4.74650066	1.1761703765	4.03555535391432	0.089512	0	0.247797369209678	0.089008	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0004185,serine-type carboxypeptidase activity	GO:0097746,blood vessel diameter maintenance;GO:0045776,negative regulation of blood pressure;GO:0042573,retinoic acid metabolic process	
GPHRB_HUMAN	P0CG08	GPR89B	Golgi pH regulator B	0.038862094	2.55E-05	0.066304876	2.55E-05	0.019443797	0.033165188	0.019443797	0.033165188	0.586271273360489	0.304432	0	1.70569503477124	0.304718	0	GO:0032580,Golgi cisterna membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0008308,voltage-gated anion channel activity	GO:0051452,intracellular pH reduction;GO:0015031,protein transport;GO:0034765,regulation of ion transmembrane transport;GO:0030217,T cell differentiation	
RLA1_HUMAN	P05386	RPLP1	60S acidic ribosomal protein P1	0.719785483	0.518066034	0.114233616	0.001830657	0.6189257585	0.0580321365	0.6189257585	0.0580321365	10.6652244054465	0.015275	1	0.0937626778382015	0.015085	-1	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0005925,focal adhesion;GO:0005840,ribosome	GO:0030295,protein kinase activator activity;GO:0043021,ribonucleoprotein complex binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006414,translational elongation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6176,path:hsa03010,Ribosome
ANK1_HUMAN	P16157	ANK1	Ankyrin-1	1.956114149	1.510826115	2.835660369	36.29808177	1.733470132	19.5668710695	1.733470132	19.5668710695	0.0885920966026121	0.000337	-1	11.2876886127392	0.000343	1	GO:0030673,axolemma;GO:0016323,basolateral plasma membrane;GO:0009898,cytoplasmic side of plasma membrane;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0031430,M band;GO:0043005,neuron projection;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0045211,postsynaptic membrane;GO:0042383,sarcolemma;GO:0016529,sarcoplasmic reticulum;GO:0014731,spectrin-associated cytoskeleton;GO:0030018,Z disc;GO:0016020,membrane	GO:0051117,ATPase binding;GO:0008093,cytoskeletal anchor activity;GO:0019899,enzyme binding;GO:0044325,ion channel binding;GO:0019903,protein phosphatase binding;GO:0030507,spectrin binding;GO:0005200,structural constituent of cytoskeleton;GO:0005198,structural molecule activity	GO:0007010,cytoskeleton organization;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006887,exocytosis;GO:0045199,maintenance of epithelial cell apical/basal polarity;GO:0010638,positive regulation of organelle organization;GO:0072659,protein localization to plasma membrane;GO:0007165,signal transduction	hsa:286,path:hsa05205,Proteoglycans in cancer
P5CS_HUMAN	P54886	ALDH18A1	Delta-1-pyrroline-5-carboxylate synthase	3.985986957	2.47892248	4.775205691	4.05082907	3.2324547185	4.4130173805	3.2324547185	4.4130173805	0.732481755631282	0.431943	0	1.36522171687152	0.432110	0	GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0004349,glutamate 5-kinase activity;GO:0004350,glutamate-5-semialdehyde dehydrogenase activity;GO:0042802,identical protein binding;GO:0003723,RNA binding	GO:0019240,citrulline biosynthetic process;GO:0006536,glutamate metabolic process;GO:0009064,glutamine family amino acid metabolic process;GO:0055129,L-proline biosynthetic process;GO:0006592,ornithine biosynthetic process;GO:0006561,proline biosynthetic process	hsa:5832,path:hsa00330,Arginine and proline metabolism
PNPT1_HUMAN	Q8TCS8	PNPT1	Polyribonucleotide nucleotidyltransferase 1, mitochondrial	0.57431698	0.426106209	0.82322375	0.481582377	0.5002115945	0.6524030635	0.5002115945	0.6524030635	0.766721713133096	0.459532	0	1.30425418097741	0.459669	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0045025,mitochondrial degradosome;GO:0005758,mitochondrial intermembrane space;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0042788,polysomal ribosome	GO:0000175,3'-5'-exoribonuclease activity;GO:0035198,miRNA binding;GO:0034046,poly(G) binding;GO:0008266,poly(U) RNA binding;GO:0004654,polyribonucleotide nucleotidyltransferase activity;GO:0003723,RNA binding	GO:0035458,cellular response to interferon-beta;GO:0034599,cellular response to oxidative stress;GO:0097421,liver regeneration;GO:0000958,mitochondrial mRNA catabolic process;GO:0097222,mitochondrial mRNA polyadenylation;GO:0000965,mitochondrial RNA 3'-end processing;GO:0000964,mitochondrial RNA 5'-end processing;GO:0000957,mitochondrial RNA catabolic process;GO:0070584,mitochondrion morphogenesis;GO:0071850,mitotic cell cycle arrest;GO:0006402,mRNA catabolic process;GO:0045926,negative regulation of growth;GO:0071042,nuclear polyadenylation-dependent mRNA catabolic process;GO:2000627,positive regulation of miRNA catabolic process;GO:0000962,positive regulation of mitochondrial RNA catabolic process;GO:0061014,positive regulation of mRNA catabolic process;GO:0051260,protein homooligomerization;GO:0070207,protein homotrimerization;GO:0043457,regulation of cellular respiration;GO:2000772,regulation of cellular senescence;GO:0051591,response to cAMP;GO:0060416,response to growth hormone;GO:0006401,RNA catabolic process;GO:0035927,RNA import into mitochondrion;GO:0043631,RNA polyadenylation;GO:0035928,rRNA import into mitochondrion	hsa:87178,path:hsa03018,RNA degradation
VATH_HUMAN	Q9UI12	ATP6V1H	V-type proton ATPase subunit H	0.629686307	0.51887649	1.25465538	0.532201146	0.5742813985	0.893428263	0.5742813985	0.893428263	0.642784006599084	0.355297	0	1.55573254737764	0.355540	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005765,lysosomal membrane;GO:0005886,plasma membrane;GO:0000221,vacuolar proton-transporting V-type ATPase, V1 domain	GO:0030234,enzyme regulator activity;GO:0046961,proton-transporting ATPase activity, rotational mechanism	GO:0034198,cellular response to amino acid starvation;GO:0006897,endocytosis;GO:0008286,insulin receptor signaling pathway;GO:0034220,ion transmembrane transport;GO:0090383,phagosome acidification;GO:1902600,proton transmembrane transport;GO:0050690,regulation of defense response to virus by virus;GO:0016241,regulation of macroautophagy;GO:0033572,transferrin transport;GO:0007035,vacuolar acidification	hsa:51606,path:hsa00190,Oxidative phosphorylation;hsa:51606,path:hsa04150,mTOR signaling pathway;hsa:51606,path:hsa04145,Phagosome;hsa:51606,path:hsa04142,Lysosome;hsa:51606,path:hsa04721,Synaptic vesicle cycle;hsa:51606,path:hsa05323,Rheumatoid arthritis;hsa:51606,path:hsa05110,Vibrio cholerae infection;hsa:51606,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:51606,path:hsa05152,Tuberculosis;hsa:51606,path:hsa05165,Human papillomavirus infection
RFC4_HUMAN	P35249	RFC4	Replication factor C subunit 4	0.245910565	0.346649536	1.081319783	1.496646595	0.2962800505	1.288983189	0.2962800505	1.288983189	0.229855635844138	0.026032	-1	4.35055680200109	0.026181	1	GO:0031390,Ctf18 RFC-like complex;GO:0005663,DNA replication factor C complex;GO:0031391,Elg1 RFC-like complex;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0003677,DNA binding	GO:0006287,base-excision repair, gap-filling;GO:0042769,DNA damage response, detection of DNA damage;GO:0032508,DNA duplex unwinding;GO:0006281,DNA repair;GO:0006260,DNA replication;GO:0006271,DNA strand elongation involved in DNA replication;GO:0006261,DNA-dependent DNA replication;GO:0070987,error-free translesion synthesis;GO:0042276,error-prone translesion synthesis;GO:0006297,nucleotide-excision repair, DNA gap filling;GO:0033683,nucleotide-excision repair, DNA incision;GO:0006296,nucleotide-excision repair, DNA incision, 5'-to lesion;GO:1900264,positive regulation of DNA-directed DNA polymerase activity;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0032201,telomere maintenance via semi-conservative replication;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0019985,translesion synthesis	hsa:5984,path:hsa03030,DNA replication;hsa:5984,path:hsa03420,Nucleotide excision repair;hsa:5984,path:hsa03430,Mismatch repair
EIF3K_HUMAN	Q9UBQ5	EIF3K	Eukaryotic translation initiation factor 3 subunit K	1.2936877	1.481884973	0.277247297	0.011898299	1.3877863365	0.144572798	1.3877863365	0.144572798	9.59922167723419	0.019033	1	0.104175112693942	0.018814	-1	GO:0005829,cytosol;GO:0016282,eukaryotic 43S preinitiation complex;GO:0033290,eukaryotic 48S preinitiation complex;GO:0005852,eukaryotic translation initiation factor 3 complex;GO:0016020,membrane;GO:0005634,nucleus	GO:0043022,ribosome binding;GO:0003743,translation initiation factor activity	GO:0001732,formation of cytoplasmic translation initiation complex;GO:0006446,regulation of translational initiation;GO:0006413,translational initiation	
NUP54_HUMAN	Q7Z3B4	NUP54	Nucleoporin p54	2.576435104	1.403827362	2.456592403	4.310452191	1.990131233	3.383522297	1.990131233	3.383522297	0.588183277161953	0.306176	0	1.70015034229655	0.306460	0	GO:0043657,host cell;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0044613,nuclear pore central transport channel	GO:0042802,identical protein binding;GO:0044877,protein-containing complex binding;GO:0017056,structural constituent of nuclear pore	GO:0075733,intracellular transport of virus;GO:0006406,mRNA export from nucleus;GO:0006607,NLS-bearing protein import into nucleus;GO:0006999,nuclear pore organization;GO:0036228,protein localization to nuclear inner membrane;GO:0016925,protein sumoylation;GO:0006605,protein targeting;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0042306,regulation of protein import into nucleus;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription	hsa:53371,path:hsa03013,RNA transport
AQP4_HUMAN	P55087	AQP4	Aquaporin-4	0.158259056	0.23846791	0.784761899	0.815892322	0.198363483	0.8003271105	0.198363483	0.8003271105	0.24785300959763	0.033819	-1	4.03464941427753	0.033994	1	GO:0097450,astrocyte end-foot;GO:0016323,basolateral plasma membrane;GO:0005737,cytoplasm;GO:0010008,endosome membrane;GO:0009897,external side of plasma membrane;GO:0005576,extracellular region;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0005886,plasma membrane;GO:0042383,sarcolemma	GO:0042802,identical protein binding;GO:0015250,water channel activity;GO:0015267,channel activity	GO:0071346,cellular response to interferon-gamma;GO:0009992,cellular water homeostasis;GO:0090660,cerebrospinal fluid circulation;GO:0050891,multicellular organismal water homeostasis;GO:0051289,protein homotetramerization;GO:0003091,renal water homeostasis;GO:0030104,water homeostasis;GO:0006833,water transport	hsa:361,path:hsa04976,Bile secretion;hsa:361,path:hsa04962,Vasopressin-regulated water reabsorption
ZN326_HUMAN	Q5BKZ1	ZNF326	DBIRD complex subunit ZNF326	0.048599782	2.55E-05	0.074473425	0.048398166	0.024312641	0.0614357955	0.024312641	0.0614357955	0.395740639510397	0.133000	0	2.52690752518412	0.133324	0	GO:0044609,DBIRD complex;GO:0043231,intracellular membrane-bounded organelle;GO:0016363,nuclear matrix;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003677,DNA binding;GO:0046872,metal ion binding;GO:0003723,RNA binding;GO:0000993,RNA polymerase II complex binding	GO:0006397,mRNA processing;GO:0032784,regulation of DNA-templated transcription, elongation;GO:0043484,regulation of RNA splicing;GO:0008380,RNA splicing	
LGMN_HUMAN	Q99538	LGMN	Legumain	0.284857134	0.385989311	1.405714903	0.429322882	0.3354232225	0.9175188925	0.3354232225	0.9175188925	0.365576366047416	0.108698	0	2.7354065877177	0.109005	0	GO:0045177,apical part of cell;GO:0005737,cytoplasm;GO:0036021,endolysosome lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005770,late endosome;GO:0043202,lysosomal lumen;GO:0005764,lysosome;GO:0048471,perinuclear region of cytoplasm	GO:0004197,cysteine-type endopeptidase activity;GO:0008233,peptidase activity;GO:0048156,tau protein binding	GO:0097202,activation of cysteine-type endopeptidase activity;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0008306,associative learning;GO:1904646,cellular response to amyloid-beta;GO:0071277,cellular response to calcium ion;GO:0035729,cellular response to hepatocyte growth factor stimulus;GO:0097061,dendritic spine organization;GO:0007613,memory;GO:1901185,negative regulation of ERBB signaling pathway;GO:0010629,negative regulation of gene expression;GO:0040015,negative regulation of multicellular organism growth;GO:0043524,negative regulation of neuron apoptotic process;GO:0008284,positive regulation of cell population proliferation;GO:2001028,positive regulation of endothelial cell chemotaxis;GO:1900273,positive regulation of long-term synaptic potentiation;GO:0045931,positive regulation of mitotic cell cycle;GO:0090026,positive regulation of monocyte chemotaxis;GO:0006508,proteolysis;GO:0051603,proteolysis involved in cellular protein catabolic process;GO:0032801,receptor catabolic process;GO:0003014,renal system process;GO:0010447,response to acidic pH;GO:0097264,self proteolysis;GO:0002224,toll-like receptor signaling pathway;GO:0006624,vacuolar protein processing;GO:0042359,vitamin D metabolic process	hsa:5641,path:hsa04142,Lysosome;hsa:5641,path:hsa04612,Antigen processing and presentation
NCF2_HUMAN	P19878	NCF2	Neutrophil cytosol factor 2	0.269592029	0.553902347	0.334965455	0.210687931	0.411747188	0.272826693	0.411747188	0.272826693	1.50918952787365	0.303365	0	0.662607301157816	0.302919	0	GO:0001669,acrosomal vesicle;GO:0005829,cytosol;GO:0016020,membrane;GO:0043020,NADPH oxidase complex;GO:0032010,phagolysosome	GO:0009055,electron transfer activity;GO:0008022,protein C-terminus binding;GO:0031267,small GTPase binding;GO:0016175,superoxide-generating NAD(P)H oxidase activity;GO:0016176,superoxide-generating NADPH oxidase activator activity	GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0045454,cell redox homeostasis;GO:0006968,cellular defense response;GO:0034599,cellular response to oxidative stress;GO:0045087,innate immune response;GO:0006909,phagocytosis;GO:0045730,respiratory burst;GO:0042554,superoxide anion generation;GO:0006801,superoxide metabolic process;GO:0048010,vascular endothelial growth factor receptor signaling pathway	hsa:4688,path:hsa04145,Phagosome;hsa:4688,path:hsa04670,Leukocyte transendothelial migration;hsa:4688,path:hsa04380,Osteoclast differentiation;hsa:4688,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:4688,path:hsa05140,Leishmaniasis
LYRIC_HUMAN	Q86UE4	MTDH	Protein LYRIC	2.175304025	3.956201519	1.95333085	3.006925039	3.065752772	2.4801279445	3.065752772	2.4801279445	1.23612686143822	0.364476	0	0.808978456172786	0.364138	0	GO:0016324,apical plasma membrane;GO:0005923,bicellular tight junction;GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0001650,fibrillar center;GO:0016021,integral component of membrane;GO:0046581,intercellular canaliculus;GO:0016604,nuclear body;GO:0031965,nuclear membrane;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm	GO:0003725,double-stranded RNA binding;GO:0051059,NF-kappaB binding;GO:0003723,RNA binding;GO:0001085,RNA polymerase II transcription factor binding;GO:0003713,transcription coactivator activity;GO:0003712,transcription coregulator activity	GO:0070830,bicellular tight junction assembly;GO:0031663,lipopolysaccharide-mediated signaling pathway;GO:0043066,negative regulation of apoptotic process;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045766,positive regulation of angiogenesis;GO:0010508,positive regulation of autophagy;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0051897,positive regulation of protein kinase B signaling;GO:0006357,regulation of transcription by RNA polymerase II	
CASP1_HUMAN	P29466	CASP1	Caspase-1	1.08526617	1.468100666	1.572384515	2.219890668	1.276683418	1.8961375915	1.276683418	1.8961375915	0.673307371639649	0.382027	0	1.4852057798874	0.382246	0	GO:0097169,AIM2 inflammasome complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0072557,IPAF inflammasome complex;GO:0005739,mitochondrion;GO:0072558,NLRP1 inflammasome complex;GO:0072559,NLRP3 inflammasome complex;GO:0005886,plasma membrane;GO:0097179,protease inhibitor complex;GO:0032991,protein-containing complex	GO:0050700,CARD domain binding;GO:0008656,cysteine-type endopeptidase activator activity involved in apoptotic process;GO:0004197,cysteine-type endopeptidase activity;GO:0097199,cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:0004175,endopeptidase activity;GO:0042802,identical protein binding;GO:0019900,kinase binding	GO:0006915,apoptotic process;GO:0071345,cellular response to cytokine stimulus;GO:0071346,cellular response to interferon-gamma;GO:0071222,cellular response to lipopolysaccharide;GO:0071260,cellular response to mechanical stimulus;GO:0071310,cellular response to organic substance;GO:0140447,cytokine precursor processing;GO:0019221,cytokine-mediated signaling pathway;GO:0097194,execution phase of apoptosis;GO:0060081,membrane hyperpolarization;GO:0051882,mitochondrial depolarization;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0032730,positive regulation of interleukin-1 alpha production;GO:0032731,positive regulation of interleukin-1 beta production;GO:1903265,positive regulation of tumor necrosis factor-mediated signaling pathway;GO:0097300,programmed necrotic cell death;GO:0016540,protein autoprocessing;GO:0006508,proteolysis;GO:0035590,purinergic nucleotide receptor signaling pathway;GO:0070269,pyroptosis;GO:0042981,regulation of apoptotic process;GO:0010506,regulation of autophagy;GO:0050727,regulation of inflammatory response;GO:0033198,response to ATP;GO:0001666,response to hypoxia;GO:0007165,signal transduction;GO:0140448,signaling receptor ligand precursor processing;GO:1901998,toxin transport	hsa:834,path:hsa04217,Necroptosis;hsa:834,path:hsa04621,NOD-like receptor signaling pathway;hsa:834,path:hsa04623,Cytosolic DNA-sensing pathway;hsa:834,path:hsa04625,C-type lectin receptor signaling pathway;hsa:834,path:hsa05014,Amyotrophic lateral sclerosis (ALS);hsa:834,path:hsa05130,Pathogenic Escherichia coli infection;hsa:834,path:hsa05132,Salmonella infection;hsa:834,path:hsa05131,Shigellosis;hsa:834,path:hsa05135,Yersinia infection;hsa:834,path:hsa05133,Pertussis;hsa:834,path:hsa05134,Legionellosis;hsa:834,path:hsa05164,Influenza A
RS18_HUMAN	P62269	RPS18	40S ribosomal protein S18	7.969940992	10.51569596	2.063230037	1.770356452	9.242818476	1.9167932445	9.242818476	1.9167932445	4.82202162519151	0.067609	0	0.207381898657554	0.067158	0	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0014069,postsynaptic density;GO:0005840,ribosome;GO:0015935,small ribosomal subunit;GO:0005581,collagen trimer	GO:0003723,RNA binding;GO:0019843,rRNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6222,path:hsa03010,Ribosome
NEUL_HUMAN	Q9BYT8	NLN	Neurolysin, mitochondrial	2.319383368	1.414009224	3.961099308	2.231863126	1.866696296	3.096481217	1.866696296	3.096481217	0.602844378887766	0.319501	0	1.6588028934515	0.319775	0	GO:0005576,extracellular region;GO:0005758,mitochondrial intermembrane space;GO:0005886,plasma membrane	GO:0046872,metal ion binding;GO:0004222,metalloendopeptidase activity;GO:0042277,peptide binding	GO:0007186,G protein-coupled receptor signaling pathway;GO:0006518,peptide metabolic process;GO:0006508,proteolysis;GO:0006111,regulation of gluconeogenesis;GO:1902809,regulation of skeletal muscle fiber differentiation	hsa:57486,path:hsa04614,Renin-angiotensin system
DPB1_HUMAN	P04440	HLA-DPB1	HLA class II histocompatibility antigen, DP beta 1 chain	1.135301687	1.543490505	1.10799167	1.812018	1.339396096	1.460004835	1.339396096	1.460004835	0.917391548227304	0.462087	0	1.0900471035866	0.461953	0	GO:0009986,cell surface;GO:0031901,early endosome membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0000139,Golgi membrane;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0042612,MHC class I protein complex;GO:0032398,MHC class Ib protein complex;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0030667,secretory granule membrane;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0030666,endocytic vesicle membrane;GO:0001772,immunological synapse;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0042613,MHC class II protein complex;GO:0032588,trans-Golgi network membrane;GO:0030658,transport vesicle membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0010008,endosome membrane;GO:0005882,intermediate filament;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0005797,Golgi medial cisterna;GO:0042824,MHC class I peptide loading complex;GO:0035577,azurophil granule membrane;GO:0033106,cis-Golgi network membrane;GO:0005769,early endosome;GO:0031527,filopodium membrane;GO:0005771,multivesicular body	GO:0030881,beta-2-microglobulin binding;GO:0042288,MHC class I protein binding;GO:0046703,natural killer cell lectin-like receptor binding;GO:0042605,peptide antigen binding;GO:0005102,signaling receptor binding;GO:0042608,T cell receptor binding;GO:0051087,chaperone binding;GO:0046977,TAP binding;GO:0023026,MHC class II protein complex binding;GO:0032395,MHC class II receptor activity;GO:0030247,polysaccharide binding;GO:0042609,CD4 receptor binding;GO:0005200,structural constituent of cytoskeleton;GO:0042610,CD8 receptor binding;GO:0003723,RNA binding;GO:0062061,TAP complex binding;GO:0071889,14-3-3 protein binding;GO:0046978,TAP1 binding;GO:0046979,TAP2 binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:1990405,protein antigen binding;GO:0015643,toxic substance binding;GO:0008134,transcription factor binding;GO:0031625,ubiquitin protein ligase binding;GO:0046872,metal ion binding	GO:0002250,adaptive immune response;GO:0019731,antibacterial humoral response;GO:0002476,antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0002477,antigen processing and presentation of exogenous peptide antigen via MHC class Ib;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0036037,CD8-positive, alpha-beta T cell activation;GO:0050830,defense response to Gram-positive bacterium;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0002519,natural killer cell tolerance induction;GO:0045953,negative regulation of natural killer cell mediated cytotoxicity;GO:0001815,positive regulation of antibody-dependent cellular cytotoxicity;GO:2001187,positive regulation of CD8-positive, alpha-beta T cell activation;GO:2000566,positive regulation of CD8-positive, alpha-beta T cell proliferation;GO:0002639,positive regulation of immunoglobulin production;GO:0032736,positive regulation of interleukin-13 production;GO:0032753,positive regulation of interleukin-4 production;GO:0002729,positive regulation of natural killer cell cytokine production;GO:0045954,positive regulation of natural killer cell mediated cytotoxicity;GO:0002717,positive regulation of natural killer cell mediated immunity;GO:0032819,positive regulation of natural killer cell proliferation;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:0032759,positive regulation of TRAIL production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0042270,protection from natural killer cell mediated cytotoxicity;GO:0050776,regulation of immune response;GO:0002715,regulation of natural killer cell mediated immunity;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process;GO:0002486,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006952,defense response;GO:0016045,detection of bacterium;GO:0006955,immune response;GO:0043312,neutrophil degranulation;GO:2001198,regulation of dendritic cell differentiation;GO:0032655,regulation of interleukin-12 production;GO:0032675,regulation of interleukin-6 production;GO:0002667,regulation of T cell anergy;GO:0002491,antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002504,antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0050890,cognition;GO:0002469,myeloid dendritic cell antigen processing and presentation;GO:0002503,peptide antigen assembly with MHC class II protein complex;GO:2000516,positive regulation of CD4-positive, alpha-beta T cell activation;GO:0032831,positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0043382,positive regulation of memory T cell differentiation;GO:0045622,regulation of T-helper cell differentiation;GO:0050852,T cell receptor signaling pathway;GO:0002399,MHC class II protein complex assembly;GO:2001190,positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0042102,positive regulation of T cell proliferation;GO:0032729,positive regulation of interferon-gamma production;GO:0050870,positive regulation of T cell activation;GO:0008544,epidermis development;GO:0006959,humoral immune response;GO:0002437,inflammatory response to antigenic stimulus;GO:0030225,macrophage differentiation;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0032689,negative regulation of interferon-gamma production;GO:0042130,negative regulation of T cell proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0033674,positive regulation of kinase activity;GO:0043410,positive regulation of MAPK cascade;GO:0045657,positive regulation of monocyte differentiation;GO:0001934,positive regulation of protein phosphorylation;GO:0002842,positive regulation of T cell mediated immune response to tumor cell;GO:0045893,positive regulation of transcription, DNA-templated;GO:0046598,positive regulation of viral entry into host cell;GO:0051262,protein tetramerization;GO:0032653,regulation of interleukin-10 production;GO:0032673,regulation of interleukin-4 production;GO:0007165,signal transduction;GO:0042088,T-helper 1 type immune response;GO:0002587,negative regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0045580,regulation of T cell differentiation;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002485,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent;GO:0042590,antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:2000568,positive regulation of memory T cell activation;GO:0002726,positive regulation of T cell cytokine production;GO:0016567,protein ubiquitination;GO:0001913,T cell mediated cytotoxicity;GO:0002419,T cell mediated cytotoxicity directed against tumor cell target;GO:0002728,negative regulation of natural killer cell cytokine production;GO:0043322,negative regulation of natural killer cell degranulation;GO:1901215,negative regulation of neuron death;GO:0002725,negative regulation of T cell cytokine production;GO:0043323,positive regulation of natural killer cell degranulation;GO:0071346,cellular response to interferon-gamma;GO:0006968,cellular defense response;GO:0002767,immune response-inhibiting cell surface receptor signaling pathway;GO:0016525,negative regulation of angiogenesis;GO:2001199,negative regulation of dendritic cell differentiation;GO:0070317,negative regulation of G0 to G1 transition;GO:0050777,negative regulation of immune response;GO:0051898,negative regulation of protein kinase B signaling;GO:0001915,negative regulation of T cell mediated cytotoxicity;GO:0002451,peripheral B cell tolerance induction;GO:2000774,positive regulation of cellular senescence;GO:2000353,positive regulation of endothelial cell apoptotic process;GO:0032735,positive regulation of interleukin-12 production;GO:0060907,positive regulation of macrophage cytokine production;GO:0045591,positive regulation of regulatory T cell differentiation;GO:0002666,positive regulation of T cell tolerance induction;GO:0002645,positive regulation of tolerance induction;GO:0070207,protein homotrimerization;GO:0019882,antigen processing and presentation;GO:0002344,B cell affinity maturation;GO:0046635,positive regulation of alpha-beta T cell activation;GO:0002579,positive regulation of antigen processing and presentation;GO:0002827,positive regulation of T-helper 1 type immune response	hsa:3133,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3133,path:hsa04144,Endocytosis;hsa:3133,path:hsa04145,Phagosome;hsa:3133,path:hsa04218,Cellular senescence;hsa:3133,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3133,path:hsa04612,Antigen processing and presentation;hsa:3133,path:hsa05203,Viral carcinogenesis;hsa:3133,path:hsa05320,Autoimmune thyroid disease;hsa:3133,path:hsa05330,Allograft rejection;hsa:3133,path:hsa05332,Graft-versus-host disease;hsa:3133,path:hsa05416,Viral myocarditis;hsa:3133,path:hsa04940,Type I diabetes mellitus;hsa:3133,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3133,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3133,path:hsa05168,Herpes simplex virus 1 infection;hsa:3133,path:hsa05163,Human cytomegalovirus infection;hsa:3133,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3133,path:hsa05169,Epstein-Barr virus infection;hsa:3133,path:hsa05165,Human papillomavirus infection;hsa:3106,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3106,path:hsa04144,Endocytosis;hsa:3106,path:hsa04145,Phagosome;hsa:3106,path:hsa04218,Cellular senescence;hsa:3106,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3106,path:hsa04612,Antigen processing and presentation;hsa:3106,path:hsa05203,Viral carcinogenesis;hsa:3106,path:hsa05320,Autoimmune thyroid disease;hsa:3106,path:hsa05330,Allograft rejection;hsa:3106,path:hsa05332,Graft-versus-host disease;hsa:3106,path:hsa05416,Viral myocarditis;hsa:3106,path:hsa04940,Type I diabetes mellitus;hsa:3106,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3106,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3106,path:hsa05168,Herpes simplex virus 1 infection;hsa:3106,path:hsa05163,Human cytomegalovirus infection;hsa:3106,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3106,path:hsa05169,Epstein-Barr virus infection;hsa:3106,path:hsa05165,Human papillomavirus infection;hsa:3122,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3122,path:hsa04145,Phagosome;hsa:3122,path:hsa04640,Hematopoietic cell lineage;hsa:3122,path:hsa04612,Antigen processing and presentation;hsa:3122,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3122,path:hsa04659,Th17 cell differentiation;hsa:3122,path:hsa04672,Intestinal immune network for IgA production;hsa:3122,path:hsa05310,Asthma;hsa:3122,path:hsa05322,Systemic lupus erythematosus;hsa:3122,path:hsa05323,Rheumatoid arthritis;hsa:3122,path:hsa05320,Autoimmune thyroid disease;hsa:3122,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3122,path:hsa05330,Allograft rejection;hsa:3122,path:hsa05332,Graft-versus-host disease;hsa:3122,path:hsa05416,Viral myocarditis;hsa:3122,path:hsa04940,Type I diabetes mellitus;hsa:3122,path:hsa05150,Staphylococcus aureus infection;hsa:3122,path:hsa05152,Tuberculosis;hsa:3122,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3122,path:hsa05164,Influenza A;hsa:3122,path:hsa05168,Herpes simplex virus 1 infection;hsa:3122,path:hsa05169,Epstein-Barr virus infection;hsa:3122,path:hsa05145,Toxoplasmosis;hsa:3122,path:hsa05140,Leishmaniasis;hsa:3109,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3109,path:hsa04145,Phagosome;hsa:3109,path:hsa04640,Hematopoietic cell lineage;hsa:3109,path:hsa04612,Antigen processing and presentation;hsa:3109,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3109,path:hsa04659,Th17 cell differentiation;hsa:3109,path:hsa04672,Intestinal immune network for IgA production;hsa:3109,path:hsa05310,Asthma;hsa:3109,path:hsa05322,Systemic lupus erythematosus;hsa:3109,path:hsa05323,Rheumatoid arthritis;hsa:3109,path:hsa05320,Autoimmune thyroid disease;hsa:3109,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3109,path:hsa05330,Allograft rejection;hsa:3109,path:hsa05332,Graft-versus-host disease;hsa:3109,path:hsa05416,Viral myocarditis;hsa:3109,path:hsa04940,Type I diabetes mellitus;hsa:3109,path:hsa05150,Staphylococcus aureus infection;hsa:3109,path:hsa05152,Tuberculosis;hsa:3109,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3109,path:hsa05164,Influenza A;hsa:3109,path:hsa05168,Herpes simplex virus 1 infection;hsa:3109,path:hsa05169,Epstein-Barr virus infection;hsa:3109,path:hsa05145,Toxoplasmosis;hsa:3109,path:hsa05140,Leishmaniasis;hsa:3115,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3115,path:hsa04145,Phagosome;hsa:3115,path:hsa04640,Hematopoietic cell lineage;hsa:3115,path:hsa04612,Antigen processing and presentation;hsa:3115,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3115,path:hsa04659,Th17 cell differentiation;hsa:3115,path:hsa04672,Intestinal immune network for IgA production;hsa:3115,path:hsa05310,Asthma;hsa:3115,path:hsa05322,Systemic lupus erythematosus;hsa:3115,path:hsa05323,Rheumatoid arthritis;hsa:3115,path:hsa05320,Autoimmune thyroid disease;hsa:3115,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3115,path:hsa05330,Allograft rejection;hsa:3115,path:hsa05332,Graft-versus-host disease;hsa:3115,path:hsa05416,Viral myocarditis;hsa:3115,path:hsa04940,Type I diabetes mellitus;hsa:3115,path:hsa05150,Staphylococcus aureus infection;hsa:3115,path:hsa05152,Tuberculosis;hsa:3115,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3115,path:hsa05164,Influenza A;hsa:3115,path:hsa05168,Herpes simplex virus 1 infection;hsa:3115,path:hsa05169,Epstein-Barr virus infection;hsa:3115,path:hsa05145,Toxoplasmosis;hsa:3115,path:hsa05140,Leishmaniasis;hsa:3123,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3123,path:hsa04145,Phagosome;hsa:3123,path:hsa04640,Hematopoietic cell lineage;hsa:3123,path:hsa04612,Antigen processing and presentation;hsa:3123,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3123,path:hsa04659,Th17 cell differentiation;hsa:3123,path:hsa04672,Intestinal immune network for IgA production;hsa:3123,path:hsa05310,Asthma;hsa:3123,path:hsa05322,Systemic lupus erythematosus;hsa:3123,path:hsa05323,Rheumatoid arthritis;hsa:3123,path:hsa05320,Autoimmune thyroid disease;hsa:3123,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3123,path:hsa05330,Allograft rejection;hsa:3123,path:hsa05332,Graft-versus-host disease;hsa:3123,path:hsa05416,Viral myocarditis;hsa:3123,path:hsa04940,Type I diabetes mellitus;hsa:3123,path:hsa05150,Staphylococcus aureus infection;hsa:3123,path:hsa05152,Tuberculosis;hsa:3123,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3123,path:hsa05164,Influenza A;hsa:3123,path:hsa05168,Herpes simplex virus 1 infection;hsa:3123,path:hsa05169,Epstein-Barr virus infection;hsa:3123,path:hsa05145,Toxoplasmosis;hsa:3123,path:hsa05140,Leishmaniasis;hsa:3111,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3111,path:hsa04145,Phagosome;hsa:3111,path:hsa04640,Hematopoietic cell lineage;hsa:3111,path:hsa04612,Antigen processing and presentation;hsa:3111,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3111,path:hsa04659,Th17 cell differentiation;hsa:3111,path:hsa04672,Intestinal immune network for IgA production;hsa:3111,path:hsa05310,Asthma;hsa:3111,path:hsa05322,Systemic lupus erythematosus;hsa:3111,path:hsa05323,Rheumatoid arthritis;hsa:3111,path:hsa05320,Autoimmune thyroid disease;hsa:3111,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3111,path:hsa05330,Allograft rejection;hsa:3111,path:hsa05332,Graft-versus-host disease;hsa:3111,path:hsa05416,Viral myocarditis;hsa:3111,path:hsa04940,Type I diabetes mellitus;hsa:3111,path:hsa05150,Staphylococcus aureus infection;hsa:3111,path:hsa05152,Tuberculosis;hsa:3111,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3111,path:hsa05164,Influenza A;hsa:3111,path:hsa05168,Herpes simplex virus 1 infection;hsa:3111,path:hsa05169,Epstein-Barr virus infection;hsa:3111,path:hsa05145,Toxoplasmosis;hsa:3111,path:hsa05140,Leishmaniasis;hsa:3112,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3112,path:hsa04145,Phagosome;hsa:3112,path:hsa04640,Hematopoietic cell lineage;hsa:3112,path:hsa04612,Antigen processing and presentation;hsa:3112,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3112,path:hsa04659,Th17 cell differentiation;hsa:3112,path:hsa04672,Intestinal immune network for IgA production;hsa:3112,path:hsa05310,Asthma;hsa:3112,path:hsa05322,Systemic lupus erythematosus;hsa:3112,path:hsa05323,Rheumatoid arthritis;hsa:3112,path:hsa05320,Autoimmune thyroid disease;hsa:3112,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3112,path:hsa05330,Allograft rejection;hsa:3112,path:hsa05332,Graft-versus-host disease;hsa:3112,path:hsa05416,Viral myocarditis;hsa:3112,path:hsa04940,Type I diabetes mellitus;hsa:3112,path:hsa05150,Staphylococcus aureus infection;hsa:3112,path:hsa05152,Tuberculosis;hsa:3112,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3112,path:hsa05164,Influenza A;hsa:3112,path:hsa05168,Herpes simplex virus 1 infection;hsa:3112,path:hsa05169,Epstein-Barr virus infection;hsa:3112,path:hsa05145,Toxoplasmosis;hsa:3112,path:hsa05140,Leishmaniasis;hsa:3105,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3105,path:hsa04144,Endocytosis;hsa:3105,path:hsa04145,Phagosome;hsa:3105,path:hsa04218,Cellular senescence;hsa:3105,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3105,path:hsa04612,Antigen processing and presentation;hsa:3105,path:hsa05203,Viral carcinogenesis;hsa:3105,path:hsa05320,Autoimmune thyroid disease;hsa:3105,path:hsa05330,Allograft rejection;hsa:3105,path:hsa05332,Graft-versus-host disease;hsa:3105,path:hsa05416,Viral myocarditis;hsa:3105,path:hsa04940,Type I diabetes mellitus;hsa:3105,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3105,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3105,path:hsa05168,Herpes simplex virus 1 infection;hsa:3105,path:hsa05163,Human cytomegalovirus infection;hsa:3105,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3105,path:hsa05169,Epstein-Barr virus infection;hsa:3105,path:hsa05165,Human papillomavirus infection;hsa:3134,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3134,path:hsa04144,Endocytosis;hsa:3134,path:hsa04145,Phagosome;hsa:3134,path:hsa04218,Cellular senescence;hsa:3134,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3134,path:hsa04612,Antigen processing and presentation;hsa:3134,path:hsa05203,Viral carcinogenesis;hsa:3134,path:hsa05320,Autoimmune thyroid disease;hsa:3134,path:hsa05330,Allograft rejection;hsa:3134,path:hsa05332,Graft-versus-host disease;hsa:3134,path:hsa05416,Viral myocarditis;hsa:3134,path:hsa04940,Type I diabetes mellitus;hsa:3134,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3134,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3134,path:hsa05168,Herpes simplex virus 1 infection;hsa:3134,path:hsa05163,Human cytomegalovirus infection;hsa:3134,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3134,path:hsa05169,Epstein-Barr virus infection;hsa:3134,path:hsa05165,Human papillomavirus infection;hsa:3119,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3119,path:hsa04145,Phagosome;hsa:3119,path:hsa04640,Hematopoietic cell lineage;hsa:3119,path:hsa04612,Antigen processing and presentation;hsa:3119,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3119,path:hsa04659,Th17 cell differentiation;hsa:3119,path:hsa04672,Intestinal immune network for IgA production;hsa:3119,path:hsa05310,Asthma;hsa:3119,path:hsa05322,Systemic lupus erythematosus;hsa:3119,path:hsa05323,Rheumatoid arthritis;hsa:3119,path:hsa05320,Autoimmune thyroid disease;hsa:3119,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3119,path:hsa05330,Allograft rejection;hsa:3119,path:hsa05332,Graft-versus-host disease;hsa:3119,path:hsa05416,Viral myocarditis;hsa:3119,path:hsa04940,Type I diabetes mellitus;hsa:3119,path:hsa05150,Staphylococcus aureus infection;hsa:3119,path:hsa05152,Tuberculosis;hsa:3119,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3119,path:hsa05164,Influenza A;hsa:3119,path:hsa05168,Herpes simplex virus 1 infection;hsa:3119,path:hsa05169,Epstein-Barr virus infection;hsa:3119,path:hsa05145,Toxoplasmosis;hsa:3119,path:hsa05140,Leishmaniasis;hsa:3113,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3113,path:hsa04145,Phagosome;hsa:3113,path:hsa04640,Hematopoietic cell lineage;hsa:3113,path:hsa04612,Antigen processing and presentation;hsa:3113,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3113,path:hsa04659,Th17 cell differentiation;hsa:3113,path:hsa04672,Intestinal immune network for IgA production;hsa:3113,path:hsa05310,Asthma;hsa:3113,path:hsa05322,Systemic lupus erythematosus;hsa:3113,path:hsa05323,Rheumatoid arthritis;hsa:3113,path:hsa05320,Autoimmune thyroid disease;hsa:3113,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3113,path:hsa05330,Allograft rejection;hsa:3113,path:hsa05332,Graft-versus-host disease;hsa:3113,path:hsa05416,Viral myocarditis;hsa:3113,path:hsa04940,Type I diabetes mellitus;hsa:3113,path:hsa05150,Staphylococcus aureus infection;hsa:3113,path:hsa05152,Tuberculosis;hsa:3113,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3113,path:hsa05164,Influenza A;hsa:3113,path:hsa05168,Herpes simplex virus 1 infection;hsa:3113,path:hsa05169,Epstein-Barr virus infection;hsa:3113,path:hsa05145,Toxoplasmosis;hsa:3113,path:hsa05140,Leishmaniasis;hsa:3125,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3125,path:hsa04145,Phagosome;hsa:3125,path:hsa04640,Hematopoietic cell lineage;hsa:3125,path:hsa04612,Antigen processing and presentation;hsa:3125,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3125,path:hsa04659,Th17 cell differentiation;hsa:3125,path:hsa04672,Intestinal immune network for IgA production;hsa:3125,path:hsa05310,Asthma;hsa:3125,path:hsa05322,Systemic lupus erythematosus;hsa:3125,path:hsa05323,Rheumatoid arthritis;hsa:3125,path:hsa05320,Autoimmune thyroid disease;hsa:3125,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3125,path:hsa05330,Allograft rejection;hsa:3125,path:hsa05332,Graft-versus-host disease;hsa:3125,path:hsa05416,Viral myocarditis;hsa:3125,path:hsa04940,Type I diabetes mellitus;hsa:3125,path:hsa05150,Staphylococcus aureus infection;hsa:3125,path:hsa05152,Tuberculosis;hsa:3125,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3125,path:hsa05164,Influenza A;hsa:3125,path:hsa05168,Herpes simplex virus 1 infection;hsa:3125,path:hsa05169,Epstein-Barr virus infection;hsa:3125,path:hsa05145,Toxoplasmosis;hsa:3125,path:hsa05140,Leishmaniasis;hsa:3126,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3126,path:hsa04145,Phagosome;hsa:3126,path:hsa04640,Hematopoietic cell lineage;hsa:3126,path:hsa04612,Antigen processing and presentation;hsa:3126,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3126,path:hsa04659,Th17 cell differentiation;hsa:3126,path:hsa04672,Intestinal immune network for IgA production;hsa:3126,path:hsa05310,Asthma;hsa:3126,path:hsa05322,Systemic lupus erythematosus;hsa:3126,path:hsa05323,Rheumatoid arthritis;hsa:3126,path:hsa05320,Autoimmune thyroid disease;hsa:3126,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3126,path:hsa05330,Allograft rejection;hsa:3126,path:hsa05332,Graft-versus-host disease;hsa:3126,path:hsa05416,Viral myocarditis;hsa:3126,path:hsa04940,Type I diabetes mellitus;hsa:3126,path:hsa05150,Staphylococcus aureus infection;hsa:3126,path:hsa05152,Tuberculosis;hsa:3126,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3126,path:hsa05164,Influenza A;hsa:3126,path:hsa05168,Herpes simplex virus 1 infection;hsa:3126,path:hsa05169,Epstein-Barr virus infection;hsa:3126,path:hsa05145,Toxoplasmosis;hsa:3126,path:hsa05140,Leishmaniasis;hsa:3107,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3107,path:hsa04144,Endocytosis;hsa:3107,path:hsa04145,Phagosome;hsa:3107,path:hsa04218,Cellular senescence;hsa:3107,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3107,path:hsa04612,Antigen processing and presentation;hsa:3107,path:hsa05203,Viral carcinogenesis;hsa:3107,path:hsa05320,Autoimmune thyroid disease;hsa:3107,path:hsa05330,Allograft rejection;hsa:3107,path:hsa05332,Graft-versus-host disease;hsa:3107,path:hsa05416,Viral myocarditis;hsa:3107,path:hsa04940,Type I diabetes mellitus;hsa:3107,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3107,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3107,path:hsa05168,Herpes simplex virus 1 infection;hsa:3107,path:hsa05163,Human cytomegalovirus infection;hsa:3107,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3107,path:hsa05169,Epstein-Barr virus infection;hsa:3107,path:hsa05165,Human papillomavirus infection;hsa:3135,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3135,path:hsa04144,Endocytosis;hsa:3135,path:hsa04145,Phagosome;hsa:3135,path:hsa04218,Cellular senescence;hsa:3135,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3135,path:hsa04612,Antigen processing and presentation;hsa:3135,path:hsa05203,Viral carcinogenesis;hsa:3135,path:hsa05320,Autoimmune thyroid disease;hsa:3135,path:hsa05330,Allograft rejection;hsa:3135,path:hsa05332,Graft-versus-host disease;hsa:3135,path:hsa05416,Viral myocarditis;hsa:3135,path:hsa04940,Type I diabetes mellitus;hsa:3135,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3135,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3135,path:hsa05168,Herpes simplex virus 1 infection;hsa:3135,path:hsa05163,Human cytomegalovirus infection;hsa:3135,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3135,path:hsa05169,Epstein-Barr virus infection;hsa:3135,path:hsa05165,Human papillomavirus infection;hsa:3127,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3127,path:hsa04145,Phagosome;hsa:3127,path:hsa04640,Hematopoietic cell lineage;hsa:3127,path:hsa04612,Antigen processing and presentation;hsa:3127,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3127,path:hsa04659,Th17 cell differentiation;hsa:3127,path:hsa04672,Intestinal immune network for IgA production;hsa:3127,path:hsa05310,Asthma;hsa:3127,path:hsa05322,Systemic lupus erythematosus;hsa:3127,path:hsa05323,Rheumatoid arthritis;hsa:3127,path:hsa05320,Autoimmune thyroid disease;hsa:3127,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3127,path:hsa05330,Allograft rejection;hsa:3127,path:hsa05332,Graft-versus-host disease;hsa:3127,path:hsa05416,Viral myocarditis;hsa:3127,path:hsa04940,Type I diabetes mellitus;hsa:3127,path:hsa05150,Staphylococcus aureus infection;hsa:3127,path:hsa05152,Tuberculosis;hsa:3127,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3127,path:hsa05164,Influenza A;hsa:3127,path:hsa05168,Herpes simplex virus 1 infection;hsa:3127,path:hsa05169,Epstein-Barr virus infection;hsa:3127,path:hsa05145,Toxoplasmosis;hsa:3127,path:hsa05140,Leishmaniasis;hsa:3118,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3118,path:hsa04145,Phagosome;hsa:3118,path:hsa04640,Hematopoietic cell lineage;hsa:3118,path:hsa04612,Antigen processing and presentation;hsa:3118,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3118,path:hsa04659,Th17 cell differentiation;hsa:3118,path:hsa04672,Intestinal immune network for IgA production;hsa:3118,path:hsa05310,Asthma;hsa:3118,path:hsa05322,Systemic lupus erythematosus;hsa:3118,path:hsa05323,Rheumatoid arthritis;hsa:3118,path:hsa05320,Autoimmune thyroid disease;hsa:3118,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3118,path:hsa05330,Allograft rejection;hsa:3118,path:hsa05332,Graft-versus-host disease;hsa:3118,path:hsa05416,Viral myocarditis;hsa:3118,path:hsa04940,Type I diabetes mellitus;hsa:3118,path:hsa05150,Staphylococcus aureus infection;hsa:3118,path:hsa05152,Tuberculosis;hsa:3118,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3118,path:hsa05164,Influenza A;hsa:3118,path:hsa05168,Herpes simplex virus 1 infection;hsa:3118,path:hsa05169,Epstein-Barr virus infection;hsa:3118,path:hsa05145,Toxoplasmosis;hsa:3118,path:hsa05140,Leishmaniasis;hsa:3117,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3117,path:hsa04145,Phagosome;hsa:3117,path:hsa04640,Hematopoietic cell lineage;hsa:3117,path:hsa04612,Antigen processing and presentation;hsa:3117,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3117,path:hsa04659,Th17 cell differentiation;hsa:3117,path:hsa04672,Intestinal immune network for IgA production;hsa:3117,path:hsa05310,Asthma;hsa:3117,path:hsa05322,Systemic lupus erythematosus;hsa:3117,path:hsa05323,Rheumatoid arthritis;hsa:3117,path:hsa05320,Autoimmune thyroid disease;hsa:3117,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3117,path:hsa05330,Allograft rejection;hsa:3117,path:hsa05332,Graft-versus-host disease;hsa:3117,path:hsa05416,Viral myocarditis;hsa:3117,path:hsa04940,Type I diabetes mellitus;hsa:3117,path:hsa05150,Staphylococcus aureus infection;hsa:3117,path:hsa05152,Tuberculosis;hsa:3117,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3117,path:hsa05164,Influenza A;hsa:3117,path:hsa05168,Herpes simplex virus 1 infection;hsa:3117,path:hsa05169,Epstein-Barr virus infection;hsa:3117,path:hsa05145,Toxoplasmosis;hsa:3117,path:hsa05140,Leishmaniasis
PDLI3_HUMAN	Q53GG5	PDLIM3	PDZ and LIM domain protein 3	0.776519904	0.674735515	0.399100938	0.219263927	0.7256277095	0.3091824325	0.7256277095	0.3091824325	2.34692412383423	0.187566	0	0.426089616551502	0.187000	0	GO:0005912,adherens junction;GO:0005829,cytosol;GO:0031941,filamentous actin;GO:0001725,stress fiber;GO:0030018,Z disc	GO:0003779,actin binding;GO:0046872,metal ion binding;GO:0051371,muscle alpha-actinin binding	GO:0030036,actin cytoskeleton organization;GO:0007507,heart development;GO:0061061,muscle structure development	
KEAP1_HUMAN	Q14145	KEAP1	Kelch-like ECH-associated protein 1	0.098389309	0.110182514	0.242382596	0.265176734	0.1042859115	0.253779665	0.1042859115	0.253779665	0.410930921120098	0.145768	0	2.43349903500628	0.146097	0	GO:0005884,actin filament;GO:0034451,centriolar satellite;GO:0031463,Cul3-RING ubiquitin ligase complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0016234,inclusion body;GO:0030496,midbody;GO:0005654,nucleoplasm	GO:0097718,disordered domain specific binding;GO:0042802,identical protein binding;GO:0008134,transcription factor binding	GO:0071353,cellular response to interleukin-4;GO:0034599,cellular response to oxidative stress;GO:0042994,cytoplasmic sequestering of transcription factor;GO:0001701,in utero embryonic development;GO:0043433,negative regulation of DNA-binding transcription factor activity;GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043687,post-translational protein modification;GO:0016579,protein deubiquitination;GO:0016567,protein ubiquitination;GO:0010506,regulation of autophagy;GO:0045604,regulation of epidermal cell differentiation;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0016032,viral process	hsa:9817,path:hsa04120,Ubiquitin mediated proteolysis;hsa:9817,path:hsa05200,Pathways in cancer;hsa:9817,path:hsa05225,Hepatocellular carcinoma;hsa:9817,path:hsa05418,Fluid shear stress and atherosclerosis
AOFB_HUMAN	P27338	MAOB	Amine oxidase [flavin-containing] B	0.303093992	0.958530869	1.162962752	5.744174524	0.6308124305	3.453568638	0.6308124305	3.453568638	0.182655246390386	0.010899	-1	5.47479483760744	0.010981	1	GO:0016021,integral component of membrane;GO:0005740,mitochondrial envelope;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion	GO:0009055,electron transfer activity;GO:0050660,flavin adenine dinucleotide binding;GO:0042802,identical protein binding;GO:0097621,monoamine oxidase activity;GO:0008131,primary amine oxidase activity	GO:0042420,dopamine catabolic process;GO:0050665,hydrogen peroxide biosynthetic process;GO:0014063,negative regulation of serotonin secretion;GO:0042135,neurotransmitter catabolic process;GO:0045964,positive regulation of dopamine metabolic process;GO:0010044,response to aluminum ion;GO:0051412,response to corticosterone;GO:0042493,response to drug;GO:0045471,response to ethanol;GO:0032496,response to lipopolysaccharide;GO:0010269,response to selenium ion;GO:0009636,response to toxic substance;GO:0021762,substantia nigra development;GO:0006805,xenobiotic metabolic process	hsa:4129,path:hsa00260,Glycine, serine and threonine metabolism;hsa:4129,path:hsa00330,Arginine and proline metabolism;hsa:4129,path:hsa00340,Histidine metabolism;hsa:4129,path:hsa00350,Tyrosine metabolism;hsa:4129,path:hsa00360,Phenylalanine metabolism;hsa:4129,path:hsa00380,Tryptophan metabolism;hsa:4129,path:hsa00982,Drug metabolism - cytochrome P450;hsa:4129,path:hsa04728,Dopaminergic synapse;hsa:4129,path:hsa04726,Serotonergic synapse;hsa:4129,path:hsa05030,Cocaine addiction;hsa:4129,path:hsa05031,Amphetamine addiction;hsa:4129,path:hsa05034,Alcoholism
H15_HUMAN	P16401	H1-5	Histone H1.5	1.203734391	1.14553276	0.72231529	1.056924727	1.1746335755	0.8896200085	1.1746335755	0.8896200085	1.32037674993458	0.343807	0	0.757359594562347	0.343431	0	GO:0015629,actin cytoskeleton;GO:0000785,chromatin;GO:0000791,euchromatin;GO:0005794,Golgi apparatus;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0000786,nucleosome;GO:0005634,nucleus;GO:0017053,transcription repressor complex;GO:0000792,heterochromatin;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0001673,male germ cell nucleus;GO:0005730,nucleolus	GO:0031490,chromatin DNA binding;GO:0003690,double-stranded DNA binding;GO:0003680,minor groove of adenine-thymine-rich DNA binding;GO:0031492,nucleosomal DNA binding;GO:0003723,RNA binding;GO:0005524,ATP binding;GO:0003677,DNA binding;GO:0043531,ADP binding;GO:0016208,AMP binding;GO:0005509,calcium ion binding;GO:0032564,dATP binding;GO:0005525,GTP binding;GO:0042826,histone deacetylase binding;GO:0042393,histone binding;GO:0003676,nucleic acid binding;GO:0045296,cadherin binding	GO:0006309,apoptotic DNA fragmentation;GO:0006342,chromatin silencing;GO:0030261,chromosome condensation;GO:0031936,negative regulation of chromatin silencing;GO:0045910,negative regulation of DNA recombination;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0006334,nucleosome assembly;GO:0016584,nucleosome positioning;GO:2000679,positive regulation of transcription regulatory region DNA binding;GO:0007275,multicellular organism development;GO:0035092,sperm chromatin condensation;GO:0007290,spermatid nucleus elongation;GO:0006325,chromatin organization;GO:0071169,establishment of protein localization to chromatin;GO:0030307,positive regulation of cell growth;GO:0051574,positive regulation of histone H3-K9 methylation;GO:0050821,protein stabilization;GO:0051321,meiotic cell cycle;GO:2000737,negative regulation of stem cell differentiation;GO:0044030,regulation of DNA methylation;GO:0006338,chromatin remodeling;GO:0007281,germ cell development;GO:0006355,regulation of transcription, DNA-templated;GO:0007283,spermatogenesis;GO:0030154,cell differentiation	
TCPA_HUMAN	P17987	TCP1	T-complex protein 1 subunit alpha	9.41683962	7.355014254	9.816831358	7.558151259	8.385926937	8.6874913085	8.385926937	8.6874913085	0.965287519631249	0.445092	0	1.03596076781559	0.444921	0	GO:0001669,acrosomal vesicle;GO:0044297,cell body;GO:0005813,centrosome;GO:0005832,chaperonin-containing T-complex;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0000792,heterochromatin;GO:0005874,microtubule;GO:0000242,pericentriolar material;GO:0002199,zona pellucida receptor complex	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0044183,protein folding chaperone;GO:0003723,RNA binding;GO:0031625,ubiquitin protein ligase binding;GO:0051082,unfolded protein binding	GO:0007339,binding of sperm to zona pellucida;GO:0035722,interleukin-12-mediated signaling pathway;GO:1904851,positive regulation of establishment of protein localization to telomere;GO:1904871,positive regulation of protein localization to Cajal body;GO:0051973,positive regulation of telomerase activity;GO:1904874,positive regulation of telomerase RNA localization to Cajal body;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:0006457,protein folding;GO:0050821,protein stabilization;GO:2000109,regulation of macrophage apoptotic process;GO:0090666,scaRNA localization to Cajal body;GO:1901998,toxin transport;GO:0044053,translocation of peptides or proteins into host cell cytoplasm;GO:0007021,tubulin complex assembly	
K2C1_HUMAN	P04264	KRT1	Keratin, type II cytoskeletal 1	786.2467555	216.8827227	400.0075103	607.2909173	501.5647391	503.6492138	501.5647391	503.6492138	0.995861256916748	0.434727	0	1.00415594346552	0.434533	0	GO:0072562,blood microparticle;GO:0062023,collagen-containing extracellular matrix;GO:0001533,cornified envelope;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0045095,keratin filament;GO:0016020,membrane;GO:0005634,nucleus	GO:0030246,carbohydrate binding;GO:0046982,protein heterodimerization activity;GO:0038023,signaling receptor activity;GO:0030280,structural constituent of skin epidermis	GO:0001867,complement activation, lectin pathway;GO:0070268,cornification;GO:0061436,establishment of skin barrier;GO:0042730,fibrinolysis;GO:0031424,keratinization;GO:0050728,negative regulation of inflammatory response;GO:0043312,neutrophil degranulation;GO:0018149,peptide cross-linking;GO:0051290,protein heterotetramerization;GO:0045765,regulation of angiogenesis;GO:0006979,response to oxidative stress;GO:0001895,retina homeostasis	
EPS15_HUMAN	P42566	EPS15	Epidermal growth factor receptor substrate 15	0.374174646	0.265382388	0.624393362	0.524863304	0.319778517	0.574628333	0.319778517	0.574628333	0.556496257903802	0.277143	0	1.79695727652649	0.277447	0	GO:0016235,aggresome;GO:0016324,apical plasma membrane;GO:0009925,basal plasma membrane;GO:0030132,clathrin coat of coated pit;GO:0005905,clathrin-coated pit;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0098978,glutamatergic synapse;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0098794,postsynapse	GO:0045296,cadherin binding;GO:0005509,calcium ion binding;GO:0031593,polyubiquitin modification-dependent protein binding;GO:0017124,SH3 domain binding	GO:0048268,clathrin coat assembly;GO:0032456,endocytic recycling;GO:0006897,endocytosis;GO:0016197,endosomal transport;GO:0006895,Golgi to endosome transport;GO:0061024,membrane organization;GO:0042059,negative regulation of epidermal growth factor receptor signaling pathway;GO:0001921,positive regulation of receptor recycling;GO:0098884,postsynaptic neurotransmitter receptor internalization;GO:0019065,receptor-mediated endocytosis of virus by host cell;GO:0042127,regulation of cell population proliferation;GO:0016050,vesicle organization;GO:0046718,viral entry into host cell	hsa:2060,path:hsa04144,Endocytosis
FAH2A_HUMAN	Q96GK7	FAHD2A	Fumarylacetoacetate hydrolase domain-containing protein 2A	0.204420655	0.067620539	0.101284289	0.154867387	0.136020597	0.128075838	0.136020597	0.128075838	1.06203167688819	0.413490	0	0.941591500293151	0.413251	0		GO:0016836,hydro-lyase activity;GO:0016787,hydrolase activity;GO:0046872,metal ion binding;GO:0003824,catalytic activity		
HVCN1_HUMAN	Q96D96	HVCN1	Voltage-gated hydrogen channel 1	0.238214002	0.862506461	0.412849467	0.416097611	0.5503602315	0.414473539	0.5503602315	0.414473539	1.32785372216488	0.342058	0	0.753095000833104	0.341678	0	GO:0016324,apical plasma membrane;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0035579,specific granule membrane	GO:0042802,identical protein binding;GO:0022843,voltage-gated cation channel activity;GO:0030171,voltage-gated proton channel activity	GO:0045454,cell redox homeostasis;GO:0071467,cellular response to pH;GO:0071294,cellular response to zinc ion;GO:0043312,neutrophil degranulation;GO:0032930,positive regulation of superoxide anion generation;GO:1902600,proton transmembrane transport;GO:0051453,regulation of intracellular pH;GO:0034765,regulation of ion transmembrane transport;GO:0009268,response to pH;GO:0010043,response to zinc ion;GO:0035036,sperm-egg recognition	
MTNA_HUMAN	Q9BV20	MRI1	Methylthioribose-1-phosphate isomerase	0.431068336	0.327439286	0.404323038	0.056562296	0.379253811	0.230442667	0.379253811	0.230442667	1.6457621148778	0.278345	0	0.607621229678296	0.277862	0	GO:0042995,cell projection;GO:0005829,cytosol;GO:0001650,fibrillar center;GO:0005654,nucleoplasm	GO:0042802,identical protein binding;GO:0046523,S-methyl-5-thioribose-1-phosphate isomerase activity	GO:0019509,L-methionine salvage from methylthioadenosine;GO:0019284,L-methionine salvage from S-adenosylmethionine	hsa:84245,path:hsa00270,Cysteine and methionine metabolism
S10A8_HUMAN	P05109	S100A8	Protein S100-A8	18.44376511	173.2580521	13.18735371	23.49779678	95.850908605	18.342575245	95.850908605	18.342575245	5.22559713261244	0.059193	0	0.191365689819274	0.058769	0	GO:0062023,collagen-containing extracellular matrix;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0045111,intermediate filament cytoskeleton;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0034774,secretory granule lumen	GO:0050544,arachidonic acid binding;GO:0005509,calcium ion binding;GO:0048306,calcium-dependent protein binding;GO:0008017,microtubule binding;GO:0050786,RAGE receptor binding;GO:0035662,Toll-like receptor 4 binding;GO:0008270,zinc ion binding	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0002526,acute inflammatory response;GO:0019730,antimicrobial humoral response;GO:0006915,apoptotic process;GO:0014002,astrocyte development;GO:0035425,autocrine signaling;GO:0006914,autophagy;GO:0002544,chronic inflammatory response;GO:0042742,defense response to bacterium;GO:0050832,defense response to fungus;GO:0006954,inflammatory response;GO:0045087,innate immune response;GO:0002523,leukocyte migration involved in inflammatory response;GO:0070488,neutrophil aggregation;GO:0030593,neutrophil chemotaxis;GO:0043312,neutrophil degranulation;GO:0018119,peptidyl-cysteine S-nitrosylation;GO:0030307,positive regulation of cell growth;GO:0050729,positive regulation of inflammatory response;GO:2001244,positive regulation of intrinsic apoptotic signaling pathway;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0002793,positive regulation of peptide secretion;GO:0051493,regulation of cytoskeleton organization;GO:0045471,response to ethanol;GO:0032496,response to lipopolysaccharide;GO:0010043,response to zinc ion;GO:0032119,sequestering of zinc ion;GO:0002224,toll-like receptor signaling pathway;GO:0042060,wound healing	hsa:6279,path:hsa04657,IL-17 signaling pathway
CUL3_HUMAN	Q13618	CUL3	Cullin-3	1.406477931	0.905069215	1.832364808	4.847811299	1.155773573	3.3400880535	1.155773573	3.3400880535	0.346030869392468	0.093843	0	2.88991557821335	0.094135	0	GO:0005813,centrosome;GO:0031463,Cul3-RING ubiquitin ligase complex;GO:0031461,cullin-RING ubiquitin ligase complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0016020,membrane;GO:0072686,mitotic spindle;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0005827,polar microtubule;GO:0036126,sperm flagellum;GO:0000922,spindle pole	GO:0030332,cyclin binding;GO:0005112,Notch binding;GO:0031208,POZ domain binding;GO:0061630,ubiquitin protein ligase activity;GO:0031625,ubiquitin protein ligase binding	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0016477,cell migration;GO:0030030,cell projection organization;GO:0048208,COPII vesicle coating;GO:0040016,embryonic cleavage;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0044346,fibroblast apoptotic process;GO:0000082,G1/S transition of mitotic cell cycle;GO:0007369,gastrulation;GO:0007229,integrin-mediated signaling pathway;GO:0097193,intrinsic apoptotic signaling pathway;GO:0072576,liver morphogenesis;GO:0000165,MAPK cascade;GO:0007080,mitotic metaphase plate congression;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0035024,negative regulation of Rho protein signal transduction;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0071630,nuclear protein quality control by the ubiquitin-proteasome system;GO:0008284,positive regulation of cell population proliferation;GO:0032467,positive regulation of cytokinesis;GO:1901992,positive regulation of mitotic cell cycle phase transition;GO:0045842,positive regulation of mitotic metaphase/anaphase transition;GO:0031398,positive regulation of protein ubiquitination;GO:0043687,post-translational protein modification;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051865,protein autoubiquitination;GO:0031648,protein destabilization;GO:0006513,protein monoubiquitination;GO:0000209,protein polyubiquitination;GO:0016567,protein ubiquitination;GO:0017145,stem cell division;GO:0043149,stress fiber assembly;GO:0001831,trophectodermal cellular morphogenesis;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0016055,Wnt signaling pathway	hsa:8452,path:hsa04120,Ubiquitin mediated proteolysis;hsa:8452,path:hsa04340,Hedgehog signaling pathway
BAG2_HUMAN	O95816	BAG2	BAG family molecular chaperone regulator 2	0.204007195	0.686886978	0.126686203	0.105778529	0.4454470865	0.116232366	0.4454470865	0.116232366	3.83238423022379	0.096762	0	0.26093417046067	0.096244	0	GO:0030424,axon;GO:0101031,chaperone complex;GO:0005829,cytosol;GO:0030425,dendrite;GO:1901588,dendritic microtubule	GO:0000774,adenyl-nucleotide exchange factor activity;GO:0051087,chaperone binding;GO:0031072,heat shock protein binding;GO:0042802,identical protein binding;GO:0044325,ion channel binding;GO:0048156,tau protein binding;GO:0031625,ubiquitin protein ligase binding	GO:0032091,negative regulation of protein binding;GO:0031397,negative regulation of protein ubiquitination;GO:1904667,negative regulation of ubiquitin protein ligase activity;GO:1901800,positive regulation of proteasomal protein catabolic process;GO:0010954,positive regulation of protein processing;GO:0006457,protein folding;GO:0019538,protein metabolic process;GO:0050821,protein stabilization;GO:1900034,regulation of cellular response to heat	hsa:9532,path:hsa04141,Protein processing in endoplasmic reticulum
SMCE1_HUMAN	Q969G3	SMARCE1	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1	0.028785864	0.020029568	0.08849939	0.037099305	0.024407716	0.0627993475	0.024407716	0.0627993475	0.388661936336202	0.127163	0	2.57293011357556	0.127484	0	GO:0000785,chromatin;GO:0071565,nBAF complex;GO:0071564,npBAF complex;GO:0000228,nuclear chromosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0016514,SWI/SNF complex	GO:0003682,chromatin binding;GO:0003677,DNA binding;GO:0008080,N-acetyltransferase activity;GO:0016922,nuclear receptor binding;GO:0047485,protein N-terminus binding;GO:0003723,RNA binding;GO:0003713,transcription coactivator activity	GO:0043044,ATP-dependent chromatin remodeling;GO:0006338,chromatin remodeling;GO:0045892,negative regulation of transcription, DNA-templated;GO:0022008,neurogenesis;GO:0006337,nucleosome disassembly;GO:0006357,regulation of transcription by RNA polymerase II	hsa:6605,path:hsa04714,Thermogenesis;hsa:6605,path:hsa05225,Hepatocellular carcinoma
NEK7_HUMAN	Q8TDX7	NEK7	Serine/threonine-protein kinase Nek7	0.290082388	0.317578934	0.315875129	0.256790646	0.303830661	0.2863328875	0.303830661	0.2863328875	1.06110989782828	0.413776	0	0.942409454521774	0.413537	0	GO:0005737,cytoplasm;GO:0005874,microtubule;GO:0005815,microtubule organizing center;GO:0005654,nucleoplasm;GO:0000922,spindle pole	GO:0005524,ATP binding;GO:0046872,metal ion binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0004672,protein kinase activity	GO:0051973,positive regulation of telomerase activity;GO:1904355,positive regulation of telomere capping;GO:0032212,positive regulation of telomere maintenance via telomerase;GO:0006468,protein phosphorylation;GO:0007346,regulation of mitotic cell cycle;GO:0051225,spindle assembly	hsa:140609,path:hsa04621,NOD-like receptor signaling pathway
RAB8A_HUMAN	P61006	RAB8A	Ras-related protein Rab-8A	0.788369127	2.037845673	0.191350393	0.023925032	1.4131074	0.1076377125	1.4131074	0.1076377125	13.128367067444	0.009693	1	0.0761709354151001	0.009555	-1	GO:0005814,centriole;GO:0005813,centrosome;GO:0005929,cilium;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0000139,Golgi membrane;GO:0030496,midbody;GO:0043025,neuronal cell body;GO:0097730,non-motile cilium;GO:0045335,phagocytic vesicle;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0055038,recycling endosome membrane;GO:0008021,synaptic vesicle;GO:0032588,trans-Golgi network membrane;GO:0030140,trans-Golgi network transport vesicle	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0031489,myosin V binding;GO:0019901,protein kinase binding;GO:0031267,small GTPase binding	GO:0006914,autophagy;GO:0007409,axonogenesis;GO:0032869,cellular response to insulin stimulus;GO:0060271,cilium assembly;GO:0048210,Golgi vesicle fusion to target membrane;GO:0098969,neurotransmitter receptor transport to postsynaptic membrane;GO:0098887,neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0043687,post-translational protein modification;GO:0072659,protein localization to plasma membrane;GO:0009306,protein secretion;GO:0010506,regulation of autophagy;GO:0017157,regulation of exocytosis;GO:0048169,regulation of long-term neuronal synaptic plasticity;GO:0051223,regulation of protein transport;GO:0006904,vesicle docking involved in exocytosis;GO:0099003,vesicle-mediated transport in synapse	hsa:4218,path:hsa04152,AMPK signaling pathway;hsa:4218,path:hsa04144,Endocytosis;hsa:4218,path:hsa04140,Autophagy - animal;hsa:4218,path:hsa04530,Tight junction;hsa:4218,path:hsa04972,Pancreatic secretion
RL4_HUMAN	P36578	RPL4	60S ribosomal protein L4	9.359030122	7.996766658	1.969900362	0.5430413	8.67789839	1.256470831	8.67789839	1.256470831	6.90656573626419	0.036195	1	0.14478976066923	0.035868	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0005791,rough endoplasmic reticulum;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6124,path:hsa03010,Ribosome
STK24_HUMAN	Q9Y6E0	STK24	Serine/threonine-protein kinase 24	0.65163435	0.43906803	0.945905716	0.627365039	0.54535119	0.7866353775	0.54535119	0.7866353775	0.693270612533569	0.399165	0	1.44243817914838	0.399366	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0045296,cadherin binding;GO:0046872,metal ion binding;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity	GO:0009267,cellular response to starvation;GO:0097194,execution phase of apoptosis;GO:0008631,intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0030336,negative regulation of cell migration;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:0048679,regulation of axon regeneration;GO:0042542,response to hydrogen peroxide;GO:0007165,signal transduction	
DTX3L_HUMAN	Q8TDB6	DTX3L	E3 ubiquitin-protein ligase DTX3L	0.270909852	0.145084757	0.310706039	0.044244358	0.2079973045	0.1774751985	0.2079973045	0.1774751985	1.17197955690693	0.381476	0	0.853257204109585	0.381172	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0008047,enzyme activator activity;GO:0019899,enzyme binding;GO:0004857,enzyme inhibitor activity;GO:0042393,histone binding;GO:0046872,metal ion binding;GO:0097677,STAT family protein binding;GO:0061630,ubiquitin protein ligase activity;GO:0044389,ubiquitin-like protein ligase binding;GO:0004842,ubiquitin-protein transferase activity	GO:0006974,cellular response to DNA damage stimulus;GO:0051607,defense response to virus;GO:0006302,double-strand break repair;GO:0008333,endosome to lysosome transport;GO:0033522,histone H2A ubiquitination;GO:0033523,histone H2B ubiquitination;GO:0010390,histone monoubiquitination;GO:0045087,innate immune response;GO:0051444,negative regulation of ubiquitin-protein transferase activity;GO:0007219,Notch signaling pathway;GO:0035563,positive regulation of chromatin binding;GO:0002230,positive regulation of defense response to virus by host;GO:2001034,positive regulation of double-strand break repair via nonhomologous end joining;GO:1901666,positive regulation of NAD+ ADP-ribosyltransferase activity;GO:0032092,positive regulation of protein binding;GO:1902966,positive regulation of protein localization to early endosome;GO:1900182,positive regulation of protein localization to nucleus;GO:2000646,positive regulation of receptor catabolic process;GO:0045893,positive regulation of transcription, DNA-templated;GO:0051865,protein autoubiquitination;GO:0070936,protein K48-linked ubiquitination;GO:0000209,protein polyubiquitination;GO:0015031,protein transport;GO:0016567,protein ubiquitination;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0016032,viral process	hsa:151636,path:hsa04330,Notch signaling pathway
TPD52_HUMAN	P55327	TPD52	Tumor protein D52	2.22622809	0.48985054	0.753599081	2.55E-05	1.358039315	0.3768122905	1.358039315	0.3768122905	3.60402075313942	0.105935	0	0.277467880596667	0.105403	0	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0048471,perinuclear region of cytoplasm	GO:0005509,calcium ion binding;GO:0042803,protein homodimerization activity	GO:0009653,anatomical structure morphogenesis;GO:0030183,B cell differentiation;GO:0046903,secretion	
TPD53_HUMAN	Q16890	TPD52L1	Tumor protein D53	0.336239796	0.304080228	0.029793178	2.55E-05	0.320160012	0.014909339	0.320160012	0.014909339	21.4737898172414	0.002955	1	0.0465683984294703	0.002899	-1	GO:0005737,cytoplasm;GO:0048471,perinuclear region of cytoplasm	GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity	GO:0000086,G2/M transition of mitotic cell cycle;GO:2001235,positive regulation of apoptotic signaling pathway;GO:0046330,positive regulation of JNK cascade;GO:0043406,positive regulation of MAP kinase activity	
PSMD7_HUMAN	P51665	PSMD7	26S proteasome non-ATPase regulatory subunit 7	0.852457583	1.164753378	2.181213807	0.582419537	1.0086054805	1.381816672	1.0086054805	1.381816672	0.729912658413778	0.429833	0	1.37002693195261	0.430002	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000502,proteasome complex;GO:0005838,proteasome regulatory particle;GO:0034774,secretory granule lumen	GO:0070122,isopeptidase activity;GO:0042803,protein homodimerization activity;GO:0008237,metallopeptidase activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0043312,neutrophil degranulation;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5713,path:hsa03050,Proteasome;hsa:5713,path:hsa05169,Epstein-Barr virus infection
RS24_HUMAN	P62847	RPS24	40S ribosomal protein S24	0.802768396	3.171781725	0.607891967	0.150102666	1.9872750605	0.3789973165	1.9872750605	0.3789973165	5.24350694314217	0.058854	0	0.190712057949665	0.058431	0	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0005783,endoplasmic reticulum;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0015935,small ribosomal subunit;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome;GO:0031369,translation initiation factor binding	GO:0002181,cytoplasmic translation;GO:0034101,erythrocyte homeostasis;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0042274,ribosomal small subunit biogenesis;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6229,path:hsa03010,Ribosome
EIF3D_HUMAN	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.980821923	0.482085069	1.094596643	0.617935043	0.731453496	0.856265843	0.731453496	0.856265843	0.854236452358406	0.486017	0	1.1706360659735	0.485935	0	GO:0005829,cytosol;GO:0016282,eukaryotic 43S preinitiation complex;GO:0033290,eukaryotic 48S preinitiation complex;GO:0005852,eukaryotic translation initiation factor 3 complex;GO:0071541,eukaryotic translation initiation factor 3 complex, eIF3m;GO:0016020,membrane	GO:0098808,mRNA cap binding;GO:0003723,RNA binding;GO:0003743,translation initiation factor activity	GO:0002191,cap-dependent translational initiation;GO:0001732,formation of cytoplasmic translation initiation complex;GO:0075522,IRES-dependent viral translational initiation;GO:1902416,positive regulation of mRNA binding;GO:0045727,positive regulation of translation;GO:0006413,translational initiation;GO:0075525,viral translational termination-reinitiation	hsa:8664,path:hsa03013,RNA transport
ARHG2_HUMAN	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	0.652291602	0.164832305	0.624046196	0.952061297	0.4085619535	0.7880537465	0.4085619535	0.7880537465	0.518444275297916	0.242092	0	1.92884760744125	0.242414	0	GO:0005923,bicellular tight junction;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0005874,microtubule;GO:0032991,protein-containing complex;GO:0032587,ruffle membrane;GO:0005819,spindle;GO:0031982,vesicle;GO:0098978,glutamatergic synapse;GO:0099092,postsynaptic density, intracellular component	GO:0005085,guanyl-nucleotide exchange factor activity;GO:0008017,microtubule binding;GO:0031267,small GTPase binding;GO:0008134,transcription factor binding;GO:0008270,zinc ion binding	GO:0007015,actin filament organization;GO:0055059,asymmetric neuroblast division;GO:0007049,cell cycle;GO:0000902,cell morphogenesis;GO:0071474,cellular hyperosmotic response;GO:0071225,cellular response to muramyl dipeptide;GO:0071356,cellular response to tumor necrosis factor;GO:0007186,G protein-coupled receptor signaling pathway;GO:0045087,innate immune response;GO:0006886,intracellular protein transport;GO:0035556,intracellular signal transduction;GO:1902042,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1902219,negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress;GO:0007026,negative regulation of microtubule depolymerization;GO:0060546,negative regulation of necroptotic process;GO:0043065,positive regulation of apoptotic process;GO:0032755,positive regulation of interleukin-6 production;GO:0045666,positive regulation of neuron differentiation;GO:2001224,positive regulation of neuron migration;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0032760,positive regulation of tumor necrosis factor production;GO:0042127,regulation of cell population proliferation;GO:0035023,regulation of Rho protein signal transduction;GO:0051056,regulation of small GTPase mediated signal transduction;GO:0030154,cell differentiation;GO:0051301,cell division;GO:0007399,nervous system development	hsa:9181,path:hsa04530,Tight junction;hsa:9181,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:9181,path:hsa05130,Pathogenic Escherichia coli infection;hsa:9181,path:hsa05131,Shigellosis
PLPHP_HUMAN	O94903	PLPBP	Pyridoxal phosphate homeostasis protein	0.236927189	0.208417324	0.532269127	0.490219966	0.2226722565	0.5112445465	0.2226722565	0.5112445465	0.435549401992496	0.167062	0	2.29595080472003	0.167396	0	GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0030170,pyridoxal phosphate binding		
RPTOR_HUMAN	Q8N122	RPTOR	Regulatory-associated protein of mTOR	0.189658626	0.190194476	0.218757618	0.25632585	0.189926551	0.237541734	0.189926551	0.237541734	0.799550242400773	0.485027	0	1.25070314155286	0.485135	0	GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0030425,dendrite;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0043025,neuronal cell body;GO:0005654,nucleoplasm;GO:0031931,TORC1 complex	GO:0071889,14-3-3 protein binding;GO:0030295,protein kinase activator activity;GO:0019901,protein kinase binding;GO:0030291,protein serine/threonine kinase inhibitor activity;GO:0044877,protein-containing complex binding;GO:0030674,protein-macromolecule adaptor activity;GO:0001002,RNA polymerase III type 1 promoter sequence-specific DNA binding;GO:0001003,RNA polymerase III type 2 promoter sequence-specific DNA binding;GO:0001006,RNA polymerase III type 3 promoter sequence-specific DNA binding;GO:0001156,TFIIIC-class transcription factor complex binding	GO:0007050,cell cycle arrest;GO:0034198,cellular response to amino acid starvation;GO:0071230,cellular response to amino acid stimulus;GO:0071233,cellular response to leucine;GO:0031669,cellular response to nutrient levels;GO:0009267,cellular response to starvation;GO:0030307,positive regulation of cell growth;GO:0001938,positive regulation of endothelial cell proliferation;GO:1900087,positive regulation of G1/S transition of mitotic cell cycle;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0010800,positive regulation of peptidyl-threonine phosphorylation;GO:0071902,positive regulation of protein serine/threonine kinase activity;GO:0032008,positive regulation of TOR signaling;GO:0045945,positive regulation of transcription by RNA polymerase III;GO:0010506,regulation of autophagy;GO:0001558,regulation of cell growth;GO:0008361,regulation of cell size;GO:1900034,regulation of cellular response to heat;GO:0016241,regulation of macroautophagy;GO:0009410,response to xenobiotic stimulus;GO:0035176,social behavior;GO:0031929,TOR signaling;GO:0038202,TORC1 signaling;GO:0016032,viral process	hsa:57521,path:hsa04151,PI3K-Akt signaling pathway;hsa:57521,path:hsa04152,AMPK signaling pathway;hsa:57521,path:hsa04150,mTOR signaling pathway;hsa:57521,path:hsa04140,Autophagy - animal;hsa:57521,path:hsa04136,Autophagy - other;hsa:57521,path:hsa04910,Insulin signaling pathway;hsa:57521,path:hsa04211,Longevity regulating pathway;hsa:57521,path:hsa04213,Longevity regulating pathway - multiple species;hsa:57521,path:hsa04714,Thermogenesis;hsa:57521,path:hsa05206,MicroRNAs in cancer;hsa:57521,path:hsa05131,Shigellosis
RS27A_HUMAN	P62979	RPS27A	Ubiquitin-40S ribosomal protein S27a	59.32961775	159.1868335	41.84336745	80.14674268	109.258225625	60.995055065	109.258225625	60.995055065	1.79126366077656	0.254893	0	0.558265107419458	0.254380	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0030666,endocytic vesicle membrane;GO:0005789,endoplasmic reticulum membrane;GO:0044322,endoplasmic reticulum quality control compartment;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0043657,host cell;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0015935,small ribosomal subunit;GO:0031982,vesicle;GO:0005840,ribosome	GO:0046872,metal ion binding;GO:0031386,protein tag;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome;GO:0031625,ubiquitin protein ligase binding	GO:0000187,activation of MAPK activity;GO:0035973,aggrephagy;GO:1990000,amyloid fibril formation;GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0019221,cytokine-mediated signaling pathway;GO:0002753,cytoplasmic pattern recognition receptor signaling pathway;GO:0002181,cytoplasmic translation;GO:0042769,DNA damage response, detection of DNA damage;GO:1904380,endoplasmic reticulum mannose trimming;GO:0016197,endosomal transport;GO:0070987,error-free translesion synthesis;GO:0042276,error-prone translesion synthesis;GO:0070911,global genome nucleotide-excision repair;GO:0007249,I-kappaB kinase/NF-kappaB signaling;GO:0070498,interleukin-1-mediated signaling pathway;GO:0036297,interstrand cross-link repair;GO:0075733,intracellular transport of virus;GO:0007254,JNK cascade;GO:0061024,membrane organization;GO:0019941,modification-dependent protein catabolic process;GO:0052031,modulation by symbiont of host defense response;GO:0002755,MyD88-dependent toll-like receptor signaling pathway;GO:0002756,MyD88-independent toll-like receptor signaling pathway;GO:0043066,negative regulation of apoptotic process;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0070423,nucleotide-binding oligomerization domain containing signaling pathway;GO:0000715,nucleotide-excision repair, DNA damage recognition;GO:0000717,nucleotide-excision repair, DNA duplex unwinding;GO:0006297,nucleotide-excision repair, DNA gap filling;GO:0033683,nucleotide-excision repair, DNA incision;GO:0006296,nucleotide-excision repair, DNA incision, 5'-to lesion;GO:0006294,nucleotide-excision repair, preincision complex assembly;GO:0043065,positive regulation of apoptotic process;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0036388,pre-replicative complex assembly;GO:0016579,protein deubiquitination;GO:0008104,protein localization;GO:0000209,protein polyubiquitination;GO:0016567,protein ubiquitination;GO:0007096,regulation of exit from mitosis;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0051403,stress-activated MAPK cascade;GO:0006283,transcription-coupled nucleotide-excision repair;GO:0007179,transforming growth factor beta receptor signaling pathway;GO:0006412,translation;GO:0006413,translational initiation;GO:0019985,translesion synthesis;GO:0055085,transmembrane transport;GO:0035666,TRIF-dependent toll-like receptor signaling pathway;GO:0019058,viral life cycle;GO:0019083,viral transcription;GO:0019081,viral translation;GO:0019068,virion assembly;GO:0016055,Wnt signaling pathway	hsa:6233,path:hsa03010,Ribosome
RL35A_HUMAN	P18077	RPL35A	60S ribosomal protein L35a	1.541548904	0.372804977	0.359964586	1.264276823	0.9571769405	0.8121207045	0.9571769405	0.8121207045	1.17861413358413	0.379664	0	0.848454105126867	0.379356	0	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome;GO:0000049,tRNA binding	GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0042273,ribosomal large subunit biogenesis;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6165,path:hsa03010,Ribosome
CACP_HUMAN	P43155	CRAT	Carnitine O-acetyltransferase	1.083378556	0.721652423	1.40621983	1.869740273	0.9025154895	1.6379800515	0.9025154895	1.6379800515	0.55099296763322	0.272079	0	1.81490519615065	0.272386	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0005782,peroxisomal matrix;GO:0005777,peroxisome	GO:0003997,acyl-CoA oxidase activity;GO:0004092,carnitine O-acetyltransferase activity;GO:0008458,carnitine O-octanoyltransferase activity;GO:0016746,transferase activity, transferring acyl groups	GO:0019254,carnitine metabolic process, CoA-linked;GO:0033540,fatty acid beta-oxidation using acyl-CoA oxidase;GO:0051791,medium-chain fatty acid metabolic process;GO:0008104,protein localization;GO:0046459,short-chain fatty acid metabolic process	
GNAS1_HUMAN	Q5JWF2	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	2.406850022	3.36765517	5.041316282	8.430434038	2.887252596	6.73587516	2.887252596	6.73587516	0.428638080044227	0.161017	0	2.33297050951894	0.161351	0	GO:0016324,apical plasma membrane;GO:0005829,cytosol;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:0005834,heterotrimeric G-protein complex;GO:0016020,membrane;GO:0005737,cytoplasm;GO:0031224,intrinsic component of membrane;GO:0005886,plasma membrane;GO:0032588,trans-Golgi network membrane;GO:0001726,ruffle;GO:0005576,extracellular region;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0030133,transport vesicle;GO:0016021,integral component of membrane	GO:0010856,adenylate cyclase activator activity;GO:0031698,beta-2 adrenergic receptor binding;GO:0051430,corticotropin-releasing hormone receptor 1 binding;GO:0031748,D1 dopamine receptor binding;GO:0001664,G protein-coupled receptor binding;GO:0031683,G-protein beta/gamma-subunit complex binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0005159,insulin-like growth factor receptor binding;GO:0035255,ionotropic glutamate receptor binding;GO:0046872,metal ion binding;GO:0031852,mu-type opioid receptor binding;GO:0019001,guanyl nucleotide binding	GO:0007191,adenylate cyclase-activating dopamine receptor signaling pathway;GO:0007189,adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007188,adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0060348,bone development;GO:0051216,cartilage development;GO:0048589,developmental growth;GO:0006306,DNA methylation;GO:0048701,embryonic cranial skeleton morphogenesis;GO:0035116,embryonic hindlimb morphogenesis;GO:0001958,endochondral ossification;GO:0006112,energy reserve metabolic process;GO:0071514,genetic imprinting;GO:0035264,multicellular organism growth;GO:0070527,platelet aggregation;GO:0120162,positive regulation of cold-induced thermogenesis;GO:0045669,positive regulation of osteoblast differentiation;GO:0045672,positive regulation of osteoclast differentiation;GO:0040032,post-embryonic body morphogenesis;GO:2000828,regulation of parathyroid hormone secretion;GO:0042493,response to drug;GO:0007606,sensory perception of chemical stimulus;GO:0043588,skin development;GO:0001894,tissue homeostasis;GO:0007190,activation of adenylate cyclase activity;GO:0071880,adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0071870,cellular response to catecholamine stimulus;GO:0071377,cellular response to glucagon stimulus;GO:0071380,cellular response to prostaglandin E stimulus;GO:0050890,cognition;GO:0007186,G protein-coupled receptor signaling pathway;GO:0060789,hair follicle placode formation;GO:0046907,intracellular transport;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0043950,positive regulation of cAMP-mediated signaling;GO:0043547,positive regulation of GTPase activity;GO:0050796,regulation of insulin secretion;GO:0003091,renal water homeostasis;GO:0007608,sensory perception of smell;GO:0009966,regulation of signal transduction;GO:0007565,female pregnancy;GO:0040015,negative regulation of multicellular organism growth;GO:0009306,protein secretion;GO:0071107,response to parathyroid hormone	hsa:2778,path:hsa04015,Rap1 signaling pathway;hsa:2778,path:hsa04020,Calcium signaling pathway;hsa:2778,path:hsa04072,Phospholipase D signaling pathway;hsa:2778,path:hsa04024,cAMP signaling pathway;hsa:2778,path:hsa04540,Gap junction;hsa:2778,path:hsa04611,Platelet activation;hsa:2778,path:hsa04911,Insulin secretion;hsa:2778,path:hsa04922,Glucagon signaling pathway;hsa:2778,path:hsa04923,Regulation of lipolysis in adipocytes;hsa:2778,path:hsa04912,GnRH signaling pathway;hsa:2778,path:hsa04913,Ovarian steroidogenesis;hsa:2778,path:hsa04915,Estrogen signaling pathway;hsa:2778,path:hsa04921,Oxytocin signaling pathway;hsa:2778,path:hsa04926,Relaxin signaling pathway;hsa:2778,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:2778,path:hsa04918,Thyroid hormone synthesis;hsa:2778,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:2778,path:hsa04916,Melanogenesis;hsa:2778,path:hsa04924,Renin secretion;hsa:2778,path:hsa04925,Aldosterone synthesis and secretion;hsa:2778,path:hsa04927,Cortisol synthesis and secretion;hsa:2778,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:2778,path:hsa04270,Vascular smooth muscle contraction;hsa:2778,path:hsa04970,Salivary secretion;hsa:2778,path:hsa04971,Gastric acid secretion;hsa:2778,path:hsa04972,Pancreatic secretion;hsa:2778,path:hsa04976,Bile secretion;hsa:2778,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:2778,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:2778,path:hsa04724,Glutamatergic synapse;hsa:2778,path:hsa04728,Dopaminergic synapse;hsa:2778,path:hsa04726,Serotonergic synapse;hsa:2778,path:hsa04730,Long-term depression;hsa:2778,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:2778,path:hsa04713,Circadian entrainment;hsa:2778,path:hsa04714,Thermogenesis;hsa:2778,path:hsa05200,Pathways in cancer;hsa:2778,path:hsa05030,Cocaine addiction;hsa:2778,path:hsa05031,Amphetamine addiction;hsa:2778,path:hsa05032,Morphine addiction;hsa:2778,path:hsa05034,Alcoholism;hsa:2778,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:2778,path:hsa04934,Cushing syndrome;hsa:2778,path:hsa05110,Vibrio cholerae infection;hsa:2778,path:hsa05163,Human cytomegalovirus infection;hsa:2778,path:hsa05165,Human papillomavirus infection;hsa:2778,path:hsa05146,Amoebiasis;hsa:2778,path:hsa05142,Chagas disease (American trypanosomiasis);hsa:2778,path:hsa01522,Endocrine resistance
AFG32_HUMAN	Q9Y4W6	AFG3L2	AFG3-like protein 2	1.741599953	0.82138996	1.555918195	1.292223375	1.2814949565	1.424070785	1.2814949565	1.424070785	0.899881501676899	0.468543	0	1.1112574246015	0.468423	0	GO:0005745,m-AAA complex;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion;GO:0016021,integral component of membrane	GO:0005524,ATP binding;GO:0004176,ATP-dependent peptidase activity;GO:0004222,metalloendopeptidase activity;GO:0008237,metallopeptidase activity;GO:0051082,unfolded protein binding;GO:0008270,zinc ion binding	GO:0007409,axonogenesis;GO:0036444,calcium import into the mitochondrion;GO:0042407,cristae formation;GO:0033619,membrane protein proteolysis;GO:0051560,mitochondrial calcium ion homeostasis;GO:0006851,mitochondrial calcium ion transmembrane transport;GO:0008053,mitochondrial fusion;GO:0034982,mitochondrial protein processing;GO:0048747,muscle fiber development;GO:0042552,myelination;GO:0021675,nerve development;GO:0007528,neuromuscular junction development;GO:0016540,protein autoprocessing;GO:0016485,protein processing;GO:0065003,protein-containing complex assembly;GO:0006508,proteolysis;GO:0040014,regulation of multicellular organism growth;GO:0060013,righting reflex	hsa:10939,path:hsa05017,Spinocerebellar ataxia
HPCL1_HUMAN	P37235	HPCAL1	Hippocalcin-like protein 1	0.090880347	0.756940544	0.019394566	2.55E-05	0.4239104455	0.009710033	0.4239104455	0.009710033	43.6569520927478	0.000403	1	0.0229058592518216	0.000392	-1	GO:0016020,membrane	GO:0005509,calcium ion binding		
K2C6B_HUMAN	P04259	KRT6B	Keratin, type II cytoskeletal 6B	4.017290311	6.134888816	2.521004393	2.152601031	5.0760895635	2.336802712	5.0760895635	2.336802712	2.17223710732325	0.205622	0	0.460354901694989	0.205065	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0045095,keratin filament	GO:0005200,structural constituent of cytoskeleton	GO:0070268,cornification;GO:0007398,ectoderm development;GO:0031424,keratinization	
IMA4_HUMAN	O00505	KPNA3	Importin subunit alpha-4	0.39369621	0.386015588	0.451648556	0.099657182	0.389855899	0.275652869	0.389855899	0.275652869	1.41430016823079	0.322753	0	0.707063480909391	0.322339	0	GO:0005829,cytosol;GO:0043657,host cell;GO:0005643,nuclear pore;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0061608,nuclear import signal receptor activity;GO:0008139,nuclear localization sequence binding;GO:0008022,protein C-terminus binding	GO:0019054,modulation by virus of host cellular process;GO:0006607,NLS-bearing protein import into nucleus;GO:0065003,protein-containing complex assembly;GO:0046718,viral entry into host cell;GO:0075732,viral penetration into host nucleus	hsa:3839,path:hsa05132,Salmonella infection
K2C6A_HUMAN	P02538	KRT6A	Keratin, type II cytoskeletal 6A	65.62440009	101.7226998	74.55725633	49.90352083	83.673549945	62.23038858	83.673549945	62.23038858	1.34457701220094	0.338192	0	0.7437283182189	0.337805	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0045095,keratin filament;GO:0016020,membrane;GO:0005634,nucleus	GO:0005200,structural constituent of cytoskeleton	GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0030154,cell differentiation;GO:0070268,cornification;GO:0051838,cytolysis by host of symbiont cells;GO:0050830,defense response to Gram-positive bacterium;GO:0031424,keratinization;GO:0002009,morphogenesis of an epithelium;GO:0001899,negative regulation of cytolysis by symbiont of host cells;GO:2000536,negative regulation of entry of bacterium into host cell;GO:0008284,positive regulation of cell population proliferation;GO:0042060,wound healing	
TMEDA_HUMAN	P49755	TMED10	Transmembrane emp24 domain-containing protein 10	9.389651553	32.60867974	1.374000678	0.492511783	20.9991656465	0.9332562305	20.9991656465	0.9332562305	22.5009648585464	0.002618	1	0.0444425386327456	0.002567	-1	GO:0005801,cis-Golgi network;GO:0030137,COPI-coated vesicle;GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0070765,gamma-secretase complex;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0042470,melanosome;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0030140,trans-Golgi network transport vesicle;GO:0030133,transport vesicle;GO:0042589,zymogen granule membrane	GO:0008320,protein transmembrane transporter activity;GO:0044877,protein-containing complex binding;GO:0019905,syntaxin binding	GO:0048205,COPI coating of Golgi vesicle;GO:0035964,COPI-coated vesicle budding;GO:0048208,COPII vesicle coating;GO:0106273,cytosol to ERGIC protein transport;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030,Golgi organization;GO:0006886,intracellular protein transport;GO:0001822,kidney development;GO:1902960,negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:0032732,positive regulation of interleukin-1 production;GO:0050714,positive regulation of protein secretion;GO:0106272,protein localization to ERGIC;GO:0045055,regulated exocytosis;GO:1902003,regulation of amyloid-beta formation;GO:0043279,response to alkaloid;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0035459,vesicle cargo loading;GO:0048199,vesicle targeting, to, from or within Golgi	hsa:10972,path:hsa05130,Pathogenic Escherichia coli infection
SELT_HUMAN	P62341	SELENOT	Thioredoxin reductase-like selenoprotein T	0.423438971	4.264590913	0.05732373	0.005431197	2.344014942	0.0313774635	2.344014942	0.0313774635	74.7037740000877	0.000071	1	0.0133862045577353	0.000069	-1	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane	GO:0008430,selenium binding;GO:0004791,thioredoxin-disulfide reductase activity	GO:0045454,cell redox homeostasis;GO:0098869,cellular oxidant detoxification;GO:0042593,glucose homeostasis;GO:0035773,insulin secretion involved in cellular response to glucose stimulus;GO:0031016,pancreas development;GO:0007204,positive regulation of cytosolic calcium ion concentration;GO:0060124,positive regulation of growth hormone secretion;GO:0009749,response to glucose;GO:0001514,selenocysteine incorporation	
KPRP_HUMAN	Q5T749	KPRP	Keratinocyte proline-rich protein	1.380965115	0.297094445	0.544574538	1.362462936	0.83902978	0.953518737	0.83902978	0.953518737	0.87993003959187	0.476064	0	1.13645398498251	0.475960	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome			
KV320_HUMAN	P01619	IGKV3-20	Immunoglobulin kappa variable 3-20	8.060664059	10.5963248	7.410093998	7.316290143	9.3284944295	7.3631920705	9.3284944295	7.3631920705	1.26690901720109	0.356715	0	0.789322663603141	0.356362	0	GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0072562,blood microparticle;GO:0005576,extracellular region;GO:0070062,extracellular exosome;GO:0071748,monomeric IgA immunoglobulin complex;GO:0071756,pentameric IgM immunoglobulin complex;GO:0071751,secretory IgA immunoglobulin complex	GO:0003823,antigen binding	GO:0002250,adaptive immune response;GO:0006955,immune response;GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0019731,antibacterial humoral response;GO:0003094,glomerular filtration	
NMD3_HUMAN	Q96D46	NMD3	60S ribosomal export protein NMD3	0.032947702	0.009289763	0.032650322	2.55E-05	0.0211187325	0.016337911	0.0211187325	0.016337911	1.29262134553187	0.350419	0	0.773621759733923	0.350055	0	GO:0005737,cytoplasm;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0030674,protein-macromolecule adaptor activity;GO:0043023,ribosomal large subunit binding;GO:0003723,RNA binding	GO:0032092,positive regulation of protein binding;GO:1904751,positive regulation of protein localization to nucleolus;GO:1902680,positive regulation of RNA biosynthetic process;GO:0000055,ribosomal large subunit export from nucleus;GO:0015031,protein transport	hsa:51068,path:hsa03013,RNA transport;hsa:51068,path:hsa03008,Ribosome biogenesis in eukaryotes
LUM_HUMAN	P51884	LUM	Lumican	25.79299629	40.02635062	37.94740591	166.3829094	32.909673455	102.165157655	32.909673455	102.165157655	0.322122279359977	0.076809	0	3.1044111633225	0.077078	0	GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005583,fibrillar collagen trimer;GO:0005796,Golgi lumen;GO:0043202,lysosomal lumen	GO:0005518,collagen binding;GO:0005201,extracellular matrix structural constituent;GO:0030021,extracellular matrix structural constituent conferring compression resistance	GO:0051216,cartilage development;GO:0030199,collagen fibril organization;GO:0030198,extracellular matrix organization;GO:0018146,keratan sulfate biosynthetic process;GO:0042340,keratan sulfate catabolic process;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0032914,positive regulation of transforming growth factor beta1 production;GO:0070848,response to growth factor;GO:0014070,response to organic cyclic compound;GO:0007601,visual perception	hsa:4060,path:hsa05205,Proteoglycans in cancer
PA24A_HUMAN	P47712	PLA2G4A	Cytosolic phospholipase A2	0.408616261	0.120913221	0.162243149	0.117428611	0.264764741	0.13983588	0.264764741	0.13983588	1.89339632288938	0.240122	0	0.528151442944587	0.239593	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005743,mitochondrial inner membrane;GO:0005635,nuclear envelope;GO:0005634,nucleus	GO:0005509,calcium ion binding;GO:0047498,calcium-dependent phospholipase A2 activity;GO:0005544,calcium-dependent phospholipid binding;GO:0047499,calcium-independent phospholipase A2 activity;GO:1902387,ceramide 1-phosphate binding;GO:0004622,lysophospholipase activity;GO:0008374,O-acyltransferase activity;GO:0102545,phosphatidyl phospholipase B activity;GO:0032266,phosphatidylinositol-3-phosphate binding;GO:0070273,phosphatidylinositol-4-phosphate binding;GO:0010314,phosphatidylinositol-5-phosphate binding;GO:0004623,phospholipase A2 activity;GO:0102567,phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine);GO:0102568,phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)	GO:0019369,arachidonic acid metabolic process;GO:0050482,arachidonic acid secretion;GO:0035965,cardiolipin acyl-chain remodeling;GO:0071236,cellular response to antibiotic;GO:0006071,glycerol metabolic process;GO:0046475,glycerophospholipid catabolic process;GO:0006690,icosanoid metabolic process;GO:0019370,leukotriene biosynthetic process;GO:0006640,monoacylglycerol biosynthetic process;GO:0006654,phosphatidic acid biosynthetic process;GO:0036151,phosphatidylcholine acyl-chain remodeling;GO:0034638,phosphatidylcholine catabolic process;GO:0036152,phosphatidylethanolamine acyl-chain remodeling;GO:0036148,phosphatidylglycerol acyl-chain remodeling;GO:0034478,phosphatidylglycerol catabolic process;GO:0036149,phosphatidylinositol acyl-chain remodeling;GO:0036150,phosphatidylserine acyl-chain remodeling;GO:0006644,phospholipid metabolic process;GO:0006663,platelet activating factor biosynthetic process;GO:0043032,positive regulation of macrophage activation;GO:0010572,positive regulation of platelet activation;GO:0032308,positive regulation of prostaglandin secretion;GO:0002827,positive regulation of T-helper 1 type immune response;GO:0001516,prostaglandin biosynthetic process;GO:0042127,regulation of cell population proliferation	hsa:5321,path:hsa00564,Glycerophospholipid metabolism;hsa:5321,path:hsa00565,Ether lipid metabolism;hsa:5321,path:hsa00590,Arachidonic acid metabolism;hsa:5321,path:hsa00591,Linoleic acid metabolism;hsa:5321,path:hsa00592,alpha-Linolenic acid metabolism;hsa:5321,path:hsa04014,Ras signaling pathway;hsa:5321,path:hsa04010,MAPK signaling pathway;hsa:5321,path:hsa04370,VEGF signaling pathway;hsa:5321,path:hsa04072,Phospholipase D signaling pathway;hsa:5321,path:hsa04217,Necroptosis;hsa:5321,path:hsa04611,Platelet activation;hsa:5321,path:hsa04664,Fc epsilon RI signaling pathway;hsa:5321,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:5321,path:hsa04912,GnRH signaling pathway;hsa:5321,path:hsa04913,Ovarian steroidogenesis;hsa:5321,path:hsa04921,Oxytocin signaling pathway;hsa:5321,path:hsa04270,Vascular smooth muscle contraction;hsa:5321,path:hsa04724,Glutamatergic synapse;hsa:5321,path:hsa04726,Serotonergic synapse;hsa:5321,path:hsa04730,Long-term depression;hsa:5321,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:5321,path:hsa05231,Choline metabolism in cancer
LRC59_HUMAN	Q96AG4	LRRC59	Leucine-rich repeat-containing protein 59	3.113230452	1.20054776	3.528297054	0.770531694	2.156889106	2.149414374	2.156889106	2.149414374	1.00347756676908	0.432200	0	0.996534484791449	0.432001	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0042645,mitochondrial nucleoid;GO:0005635,nuclear envelope	GO:0045296,cadherin binding;GO:0003723,RNA binding	GO:0046579,positive regulation of Ras protein signal transduction;GO:0007165,signal transduction	
AIMP1_HUMAN	Q12904	AIMP1	Aminoacyl tRNA synthase complex-interacting multifunctional protein 1	1.018532704	0.627510643	1.681806214	1.217119042	0.8230216735	1.449462628	0.8230216735	1.449462628	0.567811585894852	0.287539	0	1.76114757930491	0.287837	0	GO:0017101,aminoacyl-tRNA synthetase multienzyme complex;GO:0009986,cell surface;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005615,extracellular space;GO:0005794,Golgi apparatus;GO:0016020,membrane;GO:0005634,nucleus	GO:0005125,cytokine activity;GO:0051020,GTPase binding;GO:0042803,protein homodimerization activity;GO:0000049,tRNA binding	GO:0001525,angiogenesis;GO:0006915,apoptotic process;GO:0007267,cell-cell signaling;GO:0051607,defense response to virus;GO:0006954,inflammatory response;GO:0050900,leukocyte migration;GO:0001937,negative regulation of endothelial cell proliferation;GO:0070094,positive regulation of glucagon secretion;GO:0006418,tRNA aminoacylation for protein translation	
ODR4_HUMAN	Q5SWX8	ODR4	Protein odr-4 homolog	0.207763194	0.231753705	0.136837862	0.48660263	0.2197584495	0.311720246	0.2197584495	0.311720246	0.704986128812435	0.409085	0	1.41846762529147	0.409276	0	GO:0016021,integral component of membrane		GO:0008104,protein localization	
ANK3_HUMAN	Q12955	ANK3	Ankyrin-3	0.024875847	0.095167067	0.559124777	0.125799421	0.060021457	0.342462099	0.060021457	0.342462099	0.175264524673722	0.009212	-1	5.70566121045679	0.009285	1	GO:0043194,axon initial segment;GO:0009925,basal plasma membrane;GO:0016323,basolateral plasma membrane;GO:0009986,cell surface;GO:0043034,costamere;GO:0005829,cytosol;GO:0030425,dendrite;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0014704,intercalated disc;GO:0016328,lateral plasma membrane;GO:0005764,lysosome;GO:0031594,neuromuscular junction;GO:0043005,neuron projection;GO:0033268,node of Ranvier;GO:0005886,plasma membrane;GO:0045211,postsynaptic membrane;GO:0042383,sarcolemma;GO:0016529,sarcoplasmic reticulum;GO:0014731,spectrin-associated cytoskeleton;GO:0030315,T-tubule;GO:0030018,Z disc	GO:0045296,cadherin binding;GO:0008093,cytoskeletal anchor activity;GO:0008092,cytoskeletal protein binding;GO:0044325,ion channel binding;GO:0030674,protein-macromolecule adaptor activity;GO:0030507,spectrin binding;GO:0005200,structural constituent of cytoskeleton	GO:0007409,axonogenesis;GO:0071286,cellular response to magnesium ion;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0045184,establishment of protein localization;GO:0043001,Golgi to plasma membrane protein transport;GO:0010960,magnesium ion homeostasis;GO:0072660,maintenance of protein location in plasma membrane;GO:0071709,membrane assembly;GO:0000281,mitotic cytokinesis;GO:1902260,negative regulation of delayed rectifier potassium channel activity;GO:0007528,neuromuscular junction development;GO:0019228,neuronal action potential;GO:0007009,plasma membrane organization;GO:2001259,positive regulation of cation channel activity;GO:0010650,positive regulation of cell communication by electrical coupling;GO:0010628,positive regulation of gene expression;GO:0034112,positive regulation of homotypic cell-cell adhesion;GO:1900827,positive regulation of membrane depolarization during cardiac muscle cell action potential;GO:0045838,positive regulation of membrane potential;GO:0090314,positive regulation of protein targeting to membrane;GO:2000651,positive regulation of sodium ion transmembrane transporter activity;GO:0010765,positive regulation of sodium ion transport;GO:0099612,protein localization to axon;GO:0072659,protein localization to plasma membrane;GO:0043266,regulation of potassium ion transport;GO:0007165,signal transduction	hsa:288,path:hsa05205,Proteoglycans in cancer
PFD5_HUMAN	Q99471	PFDN5	Prefoldin subunit 5	0.279426333	0.338316394	0.095283232	1.171266981	0.3088713635	0.6332751065	0.3088713635	0.6332751065	0.487736467657915	0.213919	0	2.05028753499189	0.214250	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0045111,intermediate filament cytoskeleton;GO:0005634,nucleus;GO:0016272,prefoldin complex	GO:0001540,amyloid-beta binding;GO:0003714,transcription corepressor activity;GO:0051082,unfolded protein binding	GO:1905907,negative regulation of amyloid fibril formation;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0045892,negative regulation of transcription, DNA-templated;GO:0006457,protein folding;GO:0006355,regulation of transcription, DNA-templated;GO:0060041,retina development in camera-type eye	
NUDC_HUMAN	Q9Y266	NUDC	Nuclear migration protein nudC	1.76068358	0.208441464	1.320816821	1.108258932	0.984562522	1.2145378765	0.984562522	1.2145378765	0.810647853023133	0.493428	0	1.23358126006344	0.493526	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005874,microtubule;GO:0030496,midbody;GO:0072686,mitotic spindle;GO:0005654,nucleoplasm;GO:0005819,spindle;GO:0016021,integral component of membrane	GO:0045296,cadherin binding;GO:0051082,unfolded protein binding	GO:0051301,cell division;GO:0007080,mitotic metaphase plate congression;GO:0007052,mitotic spindle organization;GO:0006457,protein folding	
GRHPR_HUMAN	Q9UBQ7	GRHPR	Glyoxylate reductase/hydroxypyruvate reductase	1.575809716	5.873384049	4.41814301	4.55950287	3.7245968825	4.48882294	3.7245968825	4.48882294	0.829749119598823	0.495794	0	1.2051835625731	0.495734	0	GO:1902494,catalytic complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005782,peroxisomal matrix	GO:0008465,glycerate dehydrogenase activity;GO:0030267,glyoxylate reductase (NADP+) activity;GO:0016618,hydroxypyruvate reductase activity;GO:0051287,NAD binding;GO:0070402,NADPH binding;GO:0042803,protein homodimerization activity;GO:0031406,carboxylic acid binding;GO:0050661,NADP binding	GO:0019752,carboxylic acid metabolic process;GO:0007588,excretion;GO:0046487,glyoxylate metabolic process;GO:0043648,dicarboxylic acid metabolic process	hsa:9380,path:hsa00620,Pyruvate metabolism;hsa:9380,path:hsa00630,Glyoxylate and dicarboxylate metabolism;hsa:9380,path:hsa00260,Glycine, serine and threonine metabolism
MTREX_HUMAN	P42285	MTREX	Exosome RNA helicase MTR4	0.572662371	0.277706348	0.625205387	0.173794345	0.4251843595	0.399499866	0.4251843595	0.399499866	1.06429161981246	0.412793	0	0.939592101811544	0.412552	0	GO:0071013,catalytic step 2 spliceosome;GO:0016607,nuclear speck;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0031499,TRAMP complex	GO:0005524,ATP binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity	GO:0006974,cellular response to DNA damage stimulus;GO:0000460,maturation of 5.8S rRNA;GO:0000398,mRNA splicing, via spliceosome;GO:0006401,RNA catabolic process;GO:0006364,rRNA processing;GO:0016076,snRNA catabolic process	hsa:23517,path:hsa03018,RNA degradation
SVIL_HUMAN	O95425	SVIL	Supervillin	0.361814966	0.30923858	0.184648117	0.415187184	0.335526773	0.2999176505	0.335526773	0.2999176505	1.11872966609546	0.396502	0	0.893870995206693	0.396227	0	GO:0015629,actin cytoskeleton;GO:0042995,cell projection;GO:0032154,cleavage furrow;GO:0043034,costamere;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0036449,microtubule minus-end;GO:0030496,midbody;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0002102,podosome	GO:0051015,actin filament binding;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding	GO:0051014,actin filament severing;GO:0008154,actin polymerization or depolymerization;GO:0051016,barbed-end actin filament capping;GO:0032467,positive regulation of cytokinesis;GO:0007519,skeletal muscle tissue development;GO:0007010,cytoskeleton organization	
K22O_HUMAN	Q01546	KRT76	Keratin, type II cytoskeletal 2 oral	2.55E-05	0.06479693	2.55E-05	0.108187919	0.032411215	0.0541067095	0.032411215	0.0541067095	0.599023952842669	0.316037	0	1.66938232645706	0.316314	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005882,intermediate filament;GO:0045095,keratin filament;GO:0005634,nucleus		GO:0070268,cornification;GO:0007010,cytoskeleton organization;GO:0031424,keratinization;GO:0043473,pigmentation;GO:0048733,sebaceous gland development	
PRRC1_HUMAN	Q96M27	PRRC1	Protein PRRC1	0.50153271	0.439773365	0.851453675	0.232120751	0.4706530375	0.541787213	0.4706530375	0.541787213	0.868704587717909	0.480374	0	1.151139310346	0.480281	0	GO:0005737,cytoplasm;GO:0005794,Golgi apparatus	GO:0042802,identical protein binding;GO:0034237,protein kinase A regulatory subunit binding	GO:0034199,activation of protein kinase A activity	
MAP11_HUMAN	P53582	METAP1	Methionine aminopeptidase 1	0.323840114	0.256610341	0.526038393	5.985544167	0.2902252275	3.25579128	0.2902252275	3.25579128	0.0891412263687862	0.000349	-1	11.2181539421827	0.000355	1	GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0004177,aminopeptidase activity;GO:0046872,metal ion binding;GO:0070006,metalloaminopeptidase activity;GO:0008235,metalloexopeptidase activity	GO:0031365,N-terminal protein amino acid modification;GO:0018206,peptidyl-methionine modification;GO:0070527,platelet aggregation;GO:0070084,protein initiator methionine removal;GO:0022400,regulation of rhodopsin mediated signaling pathway;GO:0006417,regulation of translation	
LBP_HUMAN	P18428	LBP	Lipopolysaccharide-binding protein	0.245152147	0.155397074	0.285226663	1.042006398	0.2002746105	0.6636165305	0.2002746105	0.6636165305	0.301792678897109	0.063443	0	3.31353299773363	0.063690	0	GO:0009986,cell surface;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0016020,membrane	GO:0071723,lipopeptide binding;GO:0001530,lipopolysaccharide binding;GO:0070891,lipoteichoic acid binding;GO:0005102,signaling receptor binding	GO:0006953,acute-phase response;GO:0006968,cellular defense response;GO:0071222,cellular response to lipopolysaccharide;GO:0071223,cellular response to lipoteichoic acid;GO:0019221,cytokine-mediated signaling pathway;GO:0050829,defense response to Gram-negative bacterium;GO:0050830,defense response to Gram-positive bacterium;GO:0032490,detection of molecule of bacterial origin;GO:0045087,innate immune response;GO:0002232,leukocyte chemotaxis involved in inflammatory response;GO:0015920,lipopolysaccharide transport;GO:0031663,lipopolysaccharide-mediated signaling pathway;GO:0033036,macromolecule localization;GO:0002281,macrophage activation involved in immune response;GO:0032720,negative regulation of tumor necrosis factor production;GO:0008228,opsonization;GO:0032722,positive regulation of chemokine production;GO:0045919,positive regulation of cytolysis;GO:0032755,positive regulation of interleukin-6 production;GO:0032757,positive regulation of interleukin-8 production;GO:0043032,positive regulation of macrophage activation;GO:0090023,positive regulation of neutrophil chemotaxis;GO:0060265,positive regulation of respiratory burst involved in inflammatory response;GO:0034145,positive regulation of toll-like receptor 4 signaling pathway;GO:0032760,positive regulation of tumor necrosis factor production;GO:0032496,response to lipopolysaccharide;GO:0034142,toll-like receptor 4 signaling pathway;GO:0002224,toll-like receptor signaling pathway	hsa:3929,path:hsa04064,NF-kappa B signaling pathway;hsa:3929,path:hsa04620,Toll-like receptor signaling pathway;hsa:3929,path:hsa05152,Tuberculosis
ITA11_HUMAN	Q9UKX5	ITGA11	Integrin alpha-11	0.311676751	0.545187579	0.11227182	0.836076842	0.428432165	0.474174331	0.428432165	0.474174331	0.903533019378057	0.467186	0	1.10676641423503	0.467063	0	GO:0005925,focal adhesion;GO:0034681,integrin alpha11-beta1 complex;GO:0008305,integrin complex;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0005518,collagen binding;GO:0098639,collagen binding involved in cell-matrix adhesion;GO:0038064,collagen receptor activity;GO:0046872,metal ion binding	GO:0007155,cell adhesion;GO:0033627,cell adhesion mediated by integrin;GO:0007160,cell-matrix adhesion;GO:0038065,collagen-activated signaling pathway;GO:0030198,extracellular matrix organization;GO:0007229,integrin-mediated signaling pathway;GO:0007517,muscle organ development;GO:0001649,osteoblast differentiation;GO:0006929,substrate-dependent cell migration	hsa:22801,path:hsa04151,PI3K-Akt signaling pathway;hsa:22801,path:hsa04512,ECM-receptor interaction;hsa:22801,path:hsa04510,Focal adhesion;hsa:22801,path:hsa04810,Regulation of actin cytoskeleton;hsa:22801,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:22801,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:22801,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:22801,path:hsa05165,Human papillomavirus infection
G6PD_HUMAN	P11413	G6PD	Glucose-6-phosphate 1-dehydrogenase	9.161112041	79.33104736	19.03273844	16.25730725	44.2460797005	17.645022845	44.2460797005	17.645022845	2.50756715302513	0.172916	0	0.398792909212262	0.172346	0	GO:0034451,centriolar satellite;GO:0005737,cytoplasm;GO:0009898,cytoplasmic side of plasma membrane;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005634,nucleus	GO:0005536,glucose binding;GO:0004345,glucose-6-phosphate dehydrogenase activity;GO:0042802,identical protein binding;GO:0050661,NADP binding;GO:0042803,protein homodimerization activity	GO:0034599,cellular response to oxidative stress;GO:0006695,cholesterol biosynthetic process;GO:0043249,erythrocyte maturation;GO:0051156,glucose 6-phosphate metabolic process;GO:0006006,glucose metabolic process;GO:0006749,glutathione metabolic process;GO:0006629,lipid metabolic process;GO:0006739,NADP metabolic process;GO:0006740,NADPH regeneration;GO:0061052,negative regulation of cell growth involved in cardiac muscle cell development;GO:0010734,negative regulation of protein glutathionylation;GO:2000378,negative regulation of reactive oxygen species metabolic process;GO:0019322,pentose biosynthetic process;GO:0006098,pentose-phosphate shunt;GO:0009051,pentose-phosphate shunt, oxidative branch;GO:1904879,positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:0043523,regulation of neuron apoptotic process;GO:0045471,response to ethanol;GO:0032094,response to food;GO:0010041,response to iron(III) ion;GO:0014070,response to organic cyclic compound;GO:0046390,ribose phosphate biosynthetic process;GO:0021762,substantia nigra development	hsa:2539,path:hsa00030,Pentose phosphate pathway;hsa:2539,path:hsa00480,Glutathione metabolism;hsa:2539,path:hsa05230,Central carbon metabolism in cancer
CCNY_HUMAN	Q8ND76	CCNY	Cyclin-Y	0.068419482	0.090477759	0.123124045	0.124922546	0.0794486205	0.1240232955	0.0794486205	0.1240232955	0.640594334957016	0.353357	0	1.5610503331521	0.353602	0	GO:0005737,cytoplasm;GO:0000308,cytoplasmic cyclin-dependent protein kinase holoenzyme complex;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0016538,cyclin-dependent protein serine/threonine kinase regulator activity;GO:0019901,protein kinase binding	GO:0051301,cell division;GO:0000086,G2/M transition of mitotic cell cycle;GO:0045737,positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0060828,regulation of canonical Wnt signaling pathway;GO:0016055,Wnt signaling pathway	
NCPR_HUMAN	P16435	POR	NADPH--cytochrome P450 reductase	1.834910416	2.420290546	3.329736539	3.04339522	2.127600481	3.1865658795	2.127600481	3.1865658795	0.66767817188008	0.377144	0	1.49772756114544	0.377367	0	GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005783,endoplasmic reticulum;GO:0005739,mitochondrion	GO:0050660,flavin adenine dinucleotide binding;GO:0010181,FMN binding;GO:0050661,NADP binding;GO:0003958,NADPH-hemoprotein reductase activity;GO:0016491,oxidoreductase activity;GO:0016709,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0004128,cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0009055,electron transfer activity;GO:0019899,enzyme binding;GO:0016787,hydrolase activity;GO:0047726,iron-cytochrome-c reductase activity;GO:0008941,nitric oxide dioxygenase activity	GO:0090346,cellular organofluorine metabolic process;GO:0022900,electron transport chain;GO:0032770,positive regulation of monooxygenase activity;GO:0009725,response to hormone;GO:0006805,xenobiotic metabolic process;GO:0009437,carnitine metabolic process;GO:0071372,cellular response to follicle-stimulating hormone stimulus;GO:0071375,cellular response to peptide hormone stimulus;GO:0070988,demethylation;GO:0019395,fatty acid oxidation;GO:0009812,flavonoid metabolic process;GO:0018393,internal peptidyl-lysine acetylation;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0060192,negative regulation of lipase activity;GO:0043602,nitrate catabolic process;GO:0046210,nitric oxide catabolic process;GO:0045542,positive regulation of cholesterol biosynthetic process;GO:0032332,positive regulation of chondrocyte differentiation;GO:0045880,positive regulation of smoothened signaling pathway;GO:0090031,positive regulation of steroid hormone biosynthetic process;GO:0003420,regulation of growth plate cartilage chondrocyte proliferation;GO:0042493,response to drug;GO:0007584,response to nutrient	
AL7A1_HUMAN	P49419	ALDH7A1	Alpha-aminoadipic semialdehyde dehydrogenase	4.617760101	1.873889986	4.150341724	5.842408668	3.2458250435	4.996375196	3.2458250435	4.996375196	0.649635969312021	0.361349	0	1.53932363237064	0.361587	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0004029,aldehyde dehydrogenase (NAD+) activity;GO:0008802,betaine-aldehyde dehydrogenase activity;GO:0043878,glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity;GO:0042802,identical protein binding;GO:0004043,L-aminoadipate-semialdehyde dehydrogenase activity	GO:0006081,cellular aldehyde metabolic process;GO:0042426,choline catabolic process;GO:0019285,glycine betaine biosynthetic process from choline;GO:0006554,lysine catabolic process;GO:0007605,sensory perception of sound	hsa:501,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:501,path:hsa00053,Ascorbate and aldarate metabolism;hsa:501,path:hsa00620,Pyruvate metabolism;hsa:501,path:hsa00071,Fatty acid degradation;hsa:501,path:hsa00561,Glycerolipid metabolism;hsa:501,path:hsa00260,Glycine, serine and threonine metabolism;hsa:501,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:501,path:hsa00310,Lysine degradation;hsa:501,path:hsa00330,Arginine and proline metabolism;hsa:501,path:hsa00340,Histidine metabolism;hsa:501,path:hsa00380,Tryptophan metabolism;hsa:501,path:hsa00410,beta-Alanine metabolism
CSRP1_HUMAN	P21291	CSRP1	Cysteine and glycine-rich protein 1	13.16085743	22.57408567	1.55412307	1.432974883	17.86747155	1.4935489765	17.86747155	1.4935489765	11.963097180697	0.011920	1	0.0835903934320242	0.011761	-1	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005634,nucleus;GO:0030018,Z disc	GO:0042805,actinin binding;GO:0003723,RNA binding;GO:0008307,structural constituent of muscle;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0030036,actin cytoskeleton organization;GO:0060537,muscle tissue development;GO:0070527,platelet aggregation;GO:0045214,sarcomere organization	
MOB1B_HUMAN	Q7L9L4	MOB1B	MOB kinase activator 1B	0.578270742	6.03232951	0.605151195	0.275700846	3.305300126	0.4404260205	3.305300126	0.4404260205	7.50477940028977	0.030974	1	0.13324842032817	0.030675	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0019209,kinase activator activity;GO:0019900,kinase binding;GO:0046872,metal ion binding	GO:0035329,hippo signaling;GO:0031952,regulation of protein autophosphorylation	hsa:92597,path:hsa04390,Hippo signaling pathway;hsa:92597,path:hsa04392,Hippo signaling pathway - multiple species
EFTU_HUMAN	P49411	TUFM	Elongation factor Tu, mitochondrial	17.46658916	20.2304873	25.97567061	20.53954755	18.84853823	23.25760908	18.84853823	23.25760908	0.810424586859553	0.493260	0	1.23392110285679	0.493358	0	GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0042645,mitochondrial nucleoid;GO:0005739,mitochondrion;GO:0045202,synapse	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0003723,RNA binding;GO:0003746,translation elongation factor activity	GO:0070125,mitochondrial translational elongation;GO:0045471,response to ethanol;GO:0006414,translational elongation;GO:0016032,viral process	
VPP2_HUMAN	Q9Y487	ATP6V0A2	V-type proton ATPase 116 kDa subunit a2	0.016003744	0.021886221	0.03698496	0.024827869	0.0189449825	0.0309064145	0.0189449825	0.0309064145	0.612978982081535	0.328660	0	1.63137730531026	0.328927	0	GO:0001669,acrosomal vesicle;GO:0010008,endosome membrane;GO:0016021,integral component of membrane;GO:0005765,lysosomal membrane;GO:0048471,perinuclear region of cytoplasm;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0016471,vacuolar proton-transporting V-type ATPase complex;GO:0000220,vacuolar proton-transporting V-type ATPase, V0 domain;GO:0033179,proton-transporting V-type ATPase, V0 domain	GO:0051117,ATPase binding;GO:0046961,proton-transporting ATPase activity, rotational mechanism;GO:0015078,proton transmembrane transporter activity	GO:0006879,cellular iron ion homeostasis;GO:0036295,cellular response to increased oxygen levels;GO:0006955,immune response;GO:0008286,insulin receptor signaling pathway;GO:0034220,ion transmembrane transport;GO:0090383,phagosome acidification;GO:0016241,regulation of macroautophagy;GO:0033572,transferrin transport;GO:0007035,vacuolar acidification	hsa:23545,path:hsa00190,Oxidative phosphorylation;hsa:23545,path:hsa04145,Phagosome;hsa:23545,path:hsa04142,Lysosome;hsa:23545,path:hsa04966,Collecting duct acid secretion;hsa:23545,path:hsa04721,Synaptic vesicle cycle;hsa:23545,path:hsa05323,Rheumatoid arthritis;hsa:23545,path:hsa05110,Vibrio cholerae infection;hsa:23545,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:23545,path:hsa05152,Tuberculosis;hsa:23545,path:hsa05165,Human papillomavirus infection
HG2A_HUMAN	P04233	CD74	HLA class II histocompatibility antigen gamma chain	2.18060991	5.139076776	4.68665993	3.472682538	3.659843343	4.079671234	3.659843343	4.079671234	0.897092714848895	0.469583	0	1.11471198399871	0.469466	0	GO:0009986,cell surface;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0005737,cytoplasm;GO:0030666,endocytic vesicle membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0000139,Golgi membrane;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0005770,late endosome;GO:0043202,lysosomal lumen;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0035692,macrophage migration inhibitory factor receptor complex;GO:0016020,membrane;GO:0042613,MHC class II protein complex;GO:0005771,multivesicular body;GO:0035693,NOS2-CD74 complex;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0032588,trans-Golgi network membrane;GO:0030658,transport vesicle membrane;GO:0005773,vacuole	GO:0001540,amyloid-beta binding;GO:0042609,CD4 receptor binding;GO:0019955,cytokine binding;GO:0004896,cytokine receptor activity;GO:0042802,identical protein binding;GO:0035718,macrophage migration inhibitory factor binding;GO:0042289,MHC class II protein binding;GO:0042658,MHC class II protein binding, via antigen binding groove;GO:0023026,MHC class II protein complex binding;GO:0050998,nitric-oxide synthase binding;GO:0044183,protein folding chaperone	GO:0000187,activation of MAPK activity;GO:0019882,antigen processing and presentation;GO:0019883,antigen processing and presentation of endogenous antigen;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0008283,cell population proliferation;GO:0051085,chaperone cofactor-dependent protein refolding;GO:0016064,immunoglobulin mediated immune response;GO:0006886,intracellular protein transport;GO:0050900,leukocyte migration;GO:0035691,macrophage migration inhibitory factor signaling pathway;GO:0043066,negative regulation of apoptotic process;GO:0030336,negative regulation of cell migration;GO:0043518,negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:1902166,negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0002906,negative regulation of mature B cell apoptotic process;GO:0002792,negative regulation of peptide secretion;GO:0045581,negative regulation of T cell differentiation;GO:0046597,negative regulation of viral entry into host cell;GO:0045060,negative thymic T cell selection;GO:0030890,positive regulation of B cell proliferation;GO:2000343,positive regulation of chemokine (C-X-C motif) ligand 2 production;GO:0032722,positive regulation of chemokine production;GO:0001961,positive regulation of cytokine-mediated signaling pathway;GO:0002606,positive regulation of dendritic cell antigen processing and presentation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0048146,positive regulation of fibroblast proliferation;GO:0010628,positive regulation of gene expression;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0032755,positive regulation of interleukin-6 production;GO:0032757,positive regulation of interleukin-8 production;GO:0033674,positive regulation of kinase activity;GO:0060907,positive regulation of macrophage cytokine production;GO:2000448,positive regulation of macrophage migration inhibitory factor signaling pathway;GO:0043410,positive regulation of MAPK cascade;GO:0045657,positive regulation of monocyte differentiation;GO:0090023,positive regulation of neutrophil chemotaxis;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0031394,positive regulation of prostaglandin biosynthetic process;GO:0001934,positive regulation of protein phosphorylation;GO:0045582,positive regulation of T cell differentiation;GO:0045893,positive regulation of transcription, DNA-templated;GO:0002830,positive regulation of type 2 immune response;GO:0046598,positive regulation of viral entry into host cell;GO:0045059,positive thymic T cell selection;GO:0001516,prostaglandin biosynthetic process;GO:0050821,protein stabilization;GO:0070206,protein trimerization;GO:0065003,protein-containing complex assembly;GO:0043030,regulation of macrophage activation;GO:0034341,response to interferon-gamma;GO:0002286,T cell activation involved in immune response;GO:0045058,T cell selection;GO:0006955,immune response	hsa:972,path:hsa04612,Antigen processing and presentation;hsa:972,path:hsa05152,Tuberculosis;hsa:972,path:hsa05168,Herpes simplex virus 1 infection
TNPO3_HUMAN	Q9Y5L0	TNPO3	Transportin-3	0.59501507	0.464198431	0.70287046	0.822159699	0.5296067505	0.7625150795	0.5296067505	0.7625150795	0.694552494420538	0.400256	0	1.43977598242491	0.400456	0	GO:0005642,annulate lamellae;GO:0005737,cytoplasm;GO:0043231,intracellular membrane-bounded organelle;GO:0005635,nuclear envelope	GO:0042802,identical protein binding;GO:0061608,nuclear import signal receptor activity;GO:0031267,small GTPase binding	GO:0006606,protein import into nucleus	
EMAL2_HUMAN	O95834	EML2	Echinoderm microtubule-associated protein-like 2	1.122700372	0.904256164	2.085224355	1.89713888	1.013478268	1.9911816175	1.013478268	1.9911816175	0.508983338884204	0.233388	0	1.96470085286525	0.233714	0	GO:0005737,cytoplasm;GO:0005874,microtubule;GO:0005875,microtubule associated complex;GO:0005819,spindle;GO:0005856,cytoskeleton;GO:0016021,integral component of membrane	GO:0008017,microtubule binding;GO:0008022,protein C-terminus binding;GO:0005102,signaling receptor binding;GO:0015631,tubulin binding	GO:0000226,microtubule cytoskeleton organization;GO:0031115,negative regulation of microtubule polymerization;GO:0010968,regulation of microtubule nucleation;GO:0007605,sensory perception of sound;GO:0007601,visual perception	
SMAD2_HUMAN	Q15796	SMAD2	Mothers against decapentaplegic homolog 2	0.097383389	0.058287925	0.153318341	0.191393306	0.077835657	0.1723558235	0.077835657	0.1723558235	0.451598648768604	0.181268	0	2.21435560696815	0.181604	0	GO:0032444,activin responsive factor complex;GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0071144,heteromeric SMAD protein complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0071141,SMAD protein complex;GO:0005667,transcription regulator complex;GO:0016021,integral component of membrane	GO:0033613,activating transcription factor binding;GO:0003682,chromatin binding;GO:0000987,cis-regulatory region sequence-specific DNA binding;GO:0070410,co-SMAD binding;GO:0097718,disordered domain specific binding;GO:0001228,DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003700,DNA-binding transcription factor activity;GO:0000981,DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003690,double-stranded DNA binding;GO:0070411,I-SMAD binding;GO:0046872,metal ion binding;GO:0019902,phosphatase binding;GO:0070412,R-SMAD binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0046332,SMAD binding;GO:0048156,tau protein binding;GO:0008134,transcription factor binding;GO:0005160,transforming growth factor beta receptor binding;GO:0034713,type I transforming growth factor beta receptor binding;GO:0031625,ubiquitin protein ligase binding;GO:0003677,DNA binding	GO:0032924,activin receptor signaling pathway;GO:0030325,adrenal gland development;GO:0009653,anatomical structure morphogenesis;GO:0009952,anterior/posterior pattern specification;GO:0030509,BMP signaling pathway;GO:0030154,cell differentiation;GO:0045165,cell fate commitment;GO:0007182,common-partner SMAD protein phosphorylation;GO:0048701,embryonic cranial skeleton morphogenesis;GO:0048617,embryonic foregut morphogenesis;GO:0001706,endoderm formation;GO:0007369,gastrulation;GO:0001701,in utero embryonic development;GO:0030073,insulin secretion;GO:0035556,intracellular signal transduction;GO:0030324,lung development;GO:0001707,mesoderm formation;GO:0008285,negative regulation of cell population proliferation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0045892,negative regulation of transcription, DNA-templated;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0038092,nodal signaling pathway;GO:0035265,organ growth;GO:0031016,pancreas development;GO:0048340,paraxial mesoderm morphogenesis;GO:0060039,pericardium development;GO:0030513,positive regulation of BMP signaling pathway;GO:0010718,positive regulation of epithelial to mesenchymal transition;GO:0010628,positive regulation of gene expression;GO:1900224,positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0009791,post-embryonic development;GO:0031053,primary miRNA processing;GO:0016579,protein deubiquitination;GO:0051098,regulation of binding;GO:0017015,regulation of transforming growth factor beta receptor signaling pathway;GO:0070723,response to cholesterol;GO:0009749,response to glucose;GO:0062009,secondary palate development;GO:0023019,signal transduction involved in regulation of gene expression;GO:0007183,SMAD protein complex assembly;GO:0060395,SMAD protein signal transduction;GO:0035019,somatic stem cell population maintenance;GO:0007179,transforming growth factor beta receptor signaling pathway;GO:0001657,ureteric bud development;GO:0042060,wound healing;GO:0007352,zygotic specification of dorsal/ventral axis;GO:0006355,regulation of transcription, DNA-templated	hsa:4087,path:hsa04350,TGF-beta signaling pathway;hsa:4087,path:hsa04390,Hippo signaling pathway;hsa:4087,path:hsa04371,Apelin signaling pathway;hsa:4087,path:hsa04144,Endocytosis;hsa:4087,path:hsa04110,Cell cycle;hsa:4087,path:hsa04218,Cellular senescence;hsa:4087,path:hsa04550,Signaling pathways regulating pluripotency of stem cells;hsa:4087,path:hsa04659,Th17 cell differentiation;hsa:4087,path:hsa04926,Relaxin signaling pathway;hsa:4087,path:hsa05200,Pathways in cancer;hsa:4087,path:hsa05205,Proteoglycans in cancer;hsa:4087,path:hsa05210,Colorectal cancer;hsa:4087,path:hsa05212,Pancreatic cancer;hsa:4087,path:hsa05225,Hepatocellular carcinoma;hsa:4087,path:hsa05226,Gastric cancer;hsa:4087,path:hsa05321,Inflammatory bowel disease (IBD);hsa:4087,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:4087,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:4087,path:hsa05142,Chagas disease (American trypanosomiasis)
DHE3_HUMAN	P00367	GLUD1	Glutamate dehydrogenase 1, mitochondrial	9.248005883	13.03494127	14.12609045	17.41314608	11.1414735765	15.769618265	11.1414735765	15.769618265	0.706515109578019	0.410372	0	1.41539789658182	0.410562	0	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0004352,glutamate dehydrogenase (NAD+) activity;GO:0004354,glutamate dehydrogenase (NADP+) activity;GO:0004353,glutamate dehydrogenase [NAD(P)+] activity;GO:0005525,GTP binding;GO:0042802,identical protein binding;GO:0070728,leucine binding;GO:0070403,NAD+ binding	GO:0006537,glutamate biosynthetic process;GO:0006538,glutamate catabolic process;GO:0009064,glutamine family amino acid metabolic process;GO:0006541,glutamine metabolic process;GO:0032024,positive regulation of insulin secretion;GO:0021762,substantia nigra development;GO:0072350,tricarboxylic acid metabolic process	hsa:2746,path:hsa00910,Nitrogen metabolism;hsa:2746,path:hsa00250,Alanine, aspartate and glutamate metabolism;hsa:2746,path:hsa00220,Arginine biosynthesis;hsa:2746,path:hsa00471,D-Glutamine and D-glutamate metabolism;hsa:2746,path:hsa04217,Necroptosis;hsa:2746,path:hsa04964,Proximal tubule bicarbonate reclamation
CERU_HUMAN	P00450	CP	Ceruloplasmin	14.37270135	12.65000984	18.26911075	65.52476415	13.511355595	41.89693745	13.511355595	41.89693745	0.322490292067875	0.077061	0	3.10086853650009	0.077330	0	GO:0072562,blood microparticle;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005765,lysosomal membrane;GO:0005886,plasma membrane	GO:0051087,chaperone binding;GO:0005507,copper ion binding;GO:0004322,ferroxidase activity;GO:0016491,oxidoreductase activity	GO:0006879,cellular iron ion homeostasis;GO:0044267,cellular protein metabolic process;GO:0006825,copper ion transport;GO:0055072,iron ion homeostasis;GO:0006826,iron ion transport;GO:0043687,post-translational protein modification;GO:0006811,ion transport	hsa:1356,path:hsa00860,Porphyrin and chlorophyll metabolism;hsa:1356,path:hsa04216,Ferroptosis
KV106_HUMAN	A0A0C4DH72	IGKV1-6	Immunoglobulin kappa variable 1-6	0.087818385	0.210827657	0.348756199	0.202227441	0.149323021	0.27549182	0.149323021	0.27549182	0.542023429225594	0.263818	0	1.84493869836721	0.264129	0	GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0072562,blood microparticle;GO:0070062,extracellular exosome	GO:0003823,antigen binding;GO:0042802,identical protein binding	GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
MCTS1_HUMAN	Q9ULC4	MCTS1	Malignant T-cell-amplified sequence 1	2.174715073	4.513058804	0.206131078	0.017640872	3.3438869385	0.111885975	3.3438869385	0.111885975	29.8865602994477	0.001217	1	0.0334598558676717	0.001190	-1	GO:0005829,cytosol;GO:0005886,plasma membrane	GO:0003743,translation initiation factor activity	GO:0007049,cell cycle;GO:0006974,cellular response to DNA damage stimulus;GO:0001731,formation of translation preinitiation complex;GO:0075522,IRES-dependent viral translational initiation;GO:0008284,positive regulation of cell population proliferation;GO:0040008,regulation of growth;GO:0032790,ribosome disassembly;GO:0002188,translation reinitiation	
LRC15_HUMAN	Q8TF66	LRRC15	Leucine-rich repeat-containing protein 15	0.354367145	0.917697025	0.290504865	0.524087458	0.636032085	0.4072961615	0.636032085	0.4072961615	1.56159606969436	0.293386	0	0.640370464172417	0.292925	0	GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005615,extracellular space;GO:0016021,integral component of membrane	GO:0005518,collagen binding;GO:0001968,fibronectin binding;GO:0043236,laminin binding	GO:1903077,negative regulation of protein localization to plasma membrane;GO:0030335,positive regulation of cell migration;GO:0046813,receptor-mediated virion attachment to host cell	
LMOD1_HUMAN	P29536	LMOD1	Leiomodin-1	0.155347197	0.180038242	0.233366819	0.741362921	0.1676927195	0.48736487	0.1676927195	0.48736487	0.344080441210299	0.092405	0	2.90629713354968	0.092695	0	GO:0005884,actin filament;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0016020,membrane;GO:0030016,myofibril;GO:0030017,sarcomere;GO:0005865,striated muscle thin filament	GO:0003779,actin binding;GO:0005523,tropomyosin binding	GO:0007015,actin filament organization;GO:0045010,actin nucleation;GO:0006936,muscle contraction;GO:0030239,myofibril assembly;GO:0051694,pointed-end actin filament capping;GO:0030838,positive regulation of actin filament polymerization	
TENA_HUMAN	P24821	TNC	Tenascin	59.87058861	9.382978492	30.36665195	12.33208208	34.626783551	21.349367015	34.626783551	21.349367015	1.62191148462019	0.282490	0	0.616556457909399	0.282013	0	GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0005614,interstitial matrix;GO:0016020,membrane;GO:0098966,perisynaptic extracellular matrix	GO:0005201,extracellular matrix structural constituent;GO:0045545,syndecan binding	GO:0060447,bud outgrowth involved in lung branching;GO:0007155,cell adhesion;GO:0044267,cellular protein metabolic process;GO:0071799,cellular response to prostaglandin D stimulus;GO:0071300,cellular response to retinoic acid;GO:0071305,cellular response to vitamin D;GO:0030198,extracellular matrix organization;GO:0060739,mesenchymal-epithelial cell signaling involved in prostate gland development;GO:0007162,negative regulation of cell adhesion;GO:0007528,neuromuscular junction development;GO:0042475,odontogenesis of dentin-containing tooth;GO:0001649,osteoblast differentiation;GO:0014012,peripheral nervous system axon regeneration;GO:0008284,positive regulation of cell population proliferation;GO:0010628,positive regulation of gene expression;GO:0043687,post-translational protein modification;GO:0060740,prostate gland epithelium morphogenesis;GO:0045471,response to ethanol;GO:0071774,response to fibroblast growth factor;GO:0009612,response to mechanical stimulus;GO:0009611,response to wounding;GO:0042060,wound healing;GO:0042127,regulation of cell population proliferation	hsa:3371,path:hsa04151,PI3K-Akt signaling pathway;hsa:3371,path:hsa04512,ECM-receptor interaction;hsa:3371,path:hsa04510,Focal adhesion;hsa:3371,path:hsa05206,MicroRNAs in cancer;hsa:3371,path:hsa05165,Human papillomavirus infection
PSPC1_HUMAN	Q8WXF1	PSPC1	Paraspeckle component 1	1.267224502	0.801841904	1.673576261	0.821596006	1.034533203	1.2475861335	1.034533203	1.2475861335	0.829227878717843	0.496005	0	1.20594112386357	0.495946	0	GO:0005737,cytoplasm;GO:0001650,fibrillar center;GO:0016363,nuclear matrix;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003676,nucleic acid binding;GO:0003723,RNA binding;GO:0000976,transcription regulatory region sequence-specific DNA binding	GO:0002218,activation of innate immune response;GO:0045087,innate immune response;GO:0000398,mRNA splicing, via spliceosome;GO:0045892,negative regulation of transcription, DNA-templated;GO:0042752,regulation of circadian rhythm;GO:0006355,regulation of transcription, DNA-templated;GO:0048511,rhythmic process	
ESTD_HUMAN	P10768	ESD	S-formylglutathione hydrolase	1.671325494	1.567817688	2.301149901	2.387528683	1.619571591	2.344339292	1.619571591	2.344339292	0.690843512509793	0.397097	0	1.44750581266525	0.397300	0	GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005737,cytoplasm	GO:0052689,carboxylic ester hydrolase activity;GO:0016788,hydrolase activity, acting on ester bonds;GO:0042802,identical protein binding;GO:0047374,methylumbelliferyl-acetate deacetylase activity;GO:0018738,S-formylglutathione hydrolase activity	GO:0046294,formaldehyde catabolic process;GO:1901687,glutathione derivative biosynthetic process	
CO3_HUMAN	P01024	C3	Complement C3	46.94702961	46.37707769	70.37923705	338.1463414	46.66205365	204.262789225	46.66205365	204.262789225	0.228441283050339	0.025467	-1	4.37749248580275	0.025613	1	GO:0035578,azurophil granule lumen;GO:0072562,blood microparticle;GO:0009986,cell surface;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0034774,secretory granule lumen	GO:0031715,C5L2 anaphylatoxin chemotactic receptor binding;GO:0004866,endopeptidase inhibitor activity;GO:0005102,signaling receptor binding	GO:0097242,amyloid-beta clearance;GO:1905114,cell surface receptor signaling pathway involved in cell-cell signaling;GO:0044267,cellular protein metabolic process;GO:0006956,complement activation;GO:0006957,complement activation, alternative pathway;GO:0006958,complement activation, classical pathway;GO:0097278,complement-dependent cytotoxicity;GO:0150062,complement-mediated synapse pruning;GO:0006631,fatty acid metabolic process;GO:0007186,G protein-coupled receptor signaling pathway;GO:0006955,immune response;GO:0006954,inflammatory response;GO:0016322,neuron remodeling;GO:0043312,neutrophil degranulation;GO:0035846,oviduct epithelium development;GO:0001970,positive regulation of activation of membrane attack complex;GO:0045766,positive regulation of angiogenesis;GO:2000427,positive regulation of apoptotic cell clearance;GO:0045745,positive regulation of G protein-coupled receptor signaling pathway;GO:0010828,positive regulation of glucose transmembrane transport;GO:0010884,positive regulation of lipid storage;GO:0060100,positive regulation of phagocytosis, engulfment;GO:0001934,positive regulation of protein phosphorylation;GO:0048260,positive regulation of receptor-mediated endocytosis;GO:0001798,positive regulation of type IIa hypersensitivity;GO:0010575,positive regulation of vascular endothelial growth factor production;GO:0043687,post-translational protein modification;GO:0035590,purinergic nucleotide receptor signaling pathway;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0010866,regulation of triglyceride biosynthetic process;GO:0009617,response to bacterium;GO:0007165,signal transduction;GO:0150064,vertebrate eye-specific patterning	hsa:718,path:hsa04080,Neuroactive ligand-receptor interaction;hsa:718,path:hsa04145,Phagosome;hsa:718,path:hsa04610,Complement and coagulation cascades;hsa:718,path:hsa05203,Viral carcinogenesis;hsa:718,path:hsa05322,Systemic lupus erythematosus;hsa:718,path:hsa05131,Shigellosis;hsa:718,path:hsa05133,Pertussis;hsa:718,path:hsa05134,Legionellosis;hsa:718,path:hsa05150,Staphylococcus aureus infection;hsa:718,path:hsa05152,Tuberculosis;hsa:718,path:hsa05168,Herpes simplex virus 1 infection;hsa:718,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:718,path:hsa05140,Leishmaniasis;hsa:718,path:hsa05142,Chagas disease (American trypanosomiasis)
SCFD2_HUMAN	Q8WU76	SCFD2	Sec1 family domain-containing protein 2	0.082988867	0.052815537	0.149038492	0.087384497	0.067902202	0.1182114945	0.067902202	0.1182114945	0.574412854580736	0.293591	0	1.74090811517423	0.293884	0	GO:0005886,plasma membrane;GO:0030141,secretory granule	GO:0019905,syntaxin binding	GO:0006886,intracellular protein transport;GO:0006904,vesicle docking involved in exocytosis;GO:0016192,vesicle-mediated transport	
CRNL1_HUMAN	Q9BZJ0	CRNKL1	Crooked neck-like protein 1	0.439190207	0.35094571	0.772078662	0.655973924	0.3950679585	0.714026293	0.3950679585	0.714026293	0.553296093397502	0.274199	0	1.80735055232276	0.274505	0	GO:0071013,catalytic step 2 spliceosome;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0071014,post-mRNA release spliceosomal complex;GO:0000974,Prp19 complex;GO:0005681,spliceosomal complex;GO:0071007,U2-type catalytic step 2 spliceosome	GO:0003723,RNA binding	GO:0000398,mRNA splicing, via spliceosome;GO:0000245,spliceosomal complex assembly;GO:0006396,RNA processing	hsa:51340,path:hsa03040,Spliceosome
ARMC8_HUMAN	Q8IUR7	ARMC8	Armadillo repeat-containing protein 8	0.03025609	0.032121156	0.077032806	0.063805807	0.031188623	0.0704193065	0.031188623	0.0704193065	0.442898752489134	0.173540	0	2.2578523745662	0.173875	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0034657,GID complex;GO:0043231,intracellular membrane-bounded organelle;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen;GO:0000151,ubiquitin ligase complex		GO:0043312,neutrophil degranulation;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process	
TMM43_HUMAN	Q9BTV4	TMEM43	Transmembrane protein 43	2.620417906	4.793731544	5.298781134	9.968303359	3.707074725	7.6335422465	3.707074725	7.6335422465	0.485629686100146	0.211996	0	2.05918218886187	0.212329	0	GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0005639,integral component of nuclear inner membrane	GO:0042802,identical protein binding	GO:0071763,nuclear membrane organization	
CTND1_HUMAN	O60716	CTNND1	Catenin delta-1	3.000742346	2.096380832	3.681603692	4.806879459	2.548561589	4.2442415755	2.548561589	4.2442415755	0.600475148189406	0.317354	0	1.66534785496997	0.317629	0	GO:0005912,adherens junction;GO:0016342,catenin complex;GO:0005911,cell-cell junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0030426,growth cone;GO:0098686,hippocampal mossy fiber to CA3 synapse;GO:0030027,lamellipodium;GO:0030496,midbody;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0099092,postsynaptic density, intracellular component;GO:0098831,presynaptic active zone cytoplasmic component;GO:0098685,Schaffer collateral - CA1 synapse;GO:0005915,zonula adherens;GO:0030054,cell junction	GO:0045296,cadherin binding;GO:0019901,protein kinase binding;GO:0005102,signaling receptor binding	GO:0034332,adherens junction organization;GO:0007420,brain development;GO:0098609,cell-cell adhesion;GO:0044331,cell-cell adhesion mediated by cadherin;GO:0007043,cell-cell junction assembly;GO:0035635,entry of bacterium into host cell;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0050821,protein stabilization;GO:0099072,regulation of postsynaptic membrane neurotransmitter receptor levels;GO:0016055,Wnt signaling pathway	hsa:1500,path:hsa04015,Rap1 signaling pathway;hsa:1500,path:hsa04520,Adherens junction;hsa:1500,path:hsa04670,Leukocyte transendothelial migration
ITA3_HUMAN	P26006	ITGA3	Integrin alpha-3	0.036759693	0.34292168	0.19145045	2.301279341	0.1898406865	1.2463648955	0.1898406865	1.2463648955	0.152315495394182	0.005063	-1	6.56532020863715	0.005110	1	GO:0016323,basolateral plasma membrane;GO:0071944,cell periphery;GO:0009986,cell surface;GO:0060076,excitatory synapse;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0031527,filopodium membrane;GO:0005925,focal adhesion;GO:1990812,growth cone filopodium;GO:0034667,integrin alpha3-beta1 complex;GO:0008305,integrin complex;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0043235,receptor complex;GO:0097060,synaptic membrane;GO:0016020,membrane	GO:0005518,collagen binding;GO:0001968,fibronectin binding;GO:0005178,integrin binding;GO:0043236,laminin binding;GO:0046872,metal ion binding;GO:0002020,protease binding;GO:0019904,protein domain specific binding;GO:0046982,protein heterodimerization activity	GO:0007160,cell-matrix adhesion;GO:0097062,dendritic spine maintenance;GO:0035640,exploration behavior;GO:0030198,extracellular matrix organization;GO:0007507,heart development;GO:0007229,integrin-mediated signaling pathway;GO:0050900,leukocyte migration;GO:0030324,lung development;GO:0060135,maternal process involved in female pregnancy;GO:0007613,memory;GO:0048333,mesodermal cell differentiation;GO:0031345,negative regulation of cell projection organization;GO:0035024,negative regulation of Rho protein signal transduction;GO:0072006,nephron development;GO:0001764,neuron migration;GO:0010811,positive regulation of cell-substrate adhesion;GO:0010634,positive regulation of epithelial cell migration;GO:0010628,positive regulation of gene expression;GO:0010976,positive regulation of neuron projection development;GO:1903078,positive regulation of protein localization to plasma membrane;GO:0030510,regulation of BMP signaling pathway;GO:0017015,regulation of transforming growth factor beta receptor signaling pathway;GO:0030111,regulation of Wnt signaling pathway;GO:0097205,renal filtration;GO:0042493,response to drug;GO:0034698,response to gonadotropin;GO:0043588,skin development;GO:0007155,cell adhesion	hsa:3675,path:hsa04151,PI3K-Akt signaling pathway;hsa:3675,path:hsa04512,ECM-receptor interaction;hsa:3675,path:hsa04510,Focal adhesion;hsa:3675,path:hsa04810,Regulation of actin cytoskeleton;hsa:3675,path:hsa04640,Hematopoietic cell lineage;hsa:3675,path:hsa05200,Pathways in cancer;hsa:3675,path:hsa05222,Small cell lung cancer;hsa:3675,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:3675,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:3675,path:hsa05414,Dilated cardiomyopathy (DCM);hsa:3675,path:hsa05165,Human papillomavirus infection
NDUB9_HUMAN	Q9Y6M9	NDUFB9	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	0.213362638	0.967091203	0.042984022	2.55E-05	0.5902269205	0.021504761	0.5902269205	0.021504761	27.4463371390177	0.001540	1	0.0364347342574321	0.001507	-1	GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion;GO:0070469,respirasome	GO:0008137,NADH dehydrogenase (ubiquinone) activity	GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0007605,sensory perception of sound	hsa:4715,path:hsa00190,Oxidative phosphorylation;hsa:4715,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4715,path:hsa04714,Thermogenesis;hsa:4715,path:hsa05010,Alzheimer disease;hsa:4715,path:hsa05012,Parkinson disease;hsa:4715,path:hsa05016,Huntington disease;hsa:4715,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
RL8_HUMAN	P62917	RPL8	60S ribosomal protein L8	5.083896055	1.885856109	0.865034731	1.404279775	3.484876082	1.134657253	3.484876082	1.134657253	3.07130287387323	0.132720	0	0.325594720242911	0.132160	0	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0042788,polysomal ribosome;GO:0098794,postsynapse;GO:0014069,postsynaptic density;GO:0005840,ribosome	GO:1990932,5.8S rRNA binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:1990090,cellular response to nerve growth factor stimulus;GO:0002181,cytoplasmic translation;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6132,path:hsa03010,Ribosome
ACSA_HUMAN	Q9NR19	ACSS2	Acetyl-coenzyme A synthetase, cytoplasmic	0.530893043	0.0917093	0.155917299	2.045036032	0.3113011715	1.1004766655	0.3113011715	1.1004766655	0.282878484623352	0.052038	0	3.53508681061934	0.052261	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0005759,mitochondrial matrix;GO:0005654,nucleoplasm	GO:0003987,acetate-CoA ligase activity;GO:0016208,AMP binding;GO:0005524,ATP binding;GO:0050218,propionate-CoA ligase activity	GO:0019413,acetate biosynthetic process;GO:0019427,acetyl-CoA biosynthetic process from acetate;GO:0006069,ethanol oxidation;GO:0008610,lipid biosynthetic process;GO:0019542,propionate biosynthetic process	hsa:55902,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:55902,path:hsa00620,Pyruvate metabolism;hsa:55902,path:hsa00630,Glyoxylate and dicarboxylate metabolism;hsa:55902,path:hsa00640,Propanoate metabolism
COX2_HUMAN	P00403	MT-CO2	Cytochrome c oxidase subunit 2	9.710662266	59.76500612	2.47288802	1.617408402	34.737834193	2.045148211	34.737834193	2.045148211	16.9854849668888	0.005307	1	0.058873797359886	0.005219	-1	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0005750,mitochondrial respiratory chain complex III;GO:0005751,mitochondrial respiratory chain complex IV;GO:0045277,respiratory chain complex IV;GO:0005739,mitochondrion;GO:0005753,mitochondrial proton-transporting ATP synthase complex;GO:0045263,proton-transporting ATP synthase complex, coupling factor F(o);GO:0000276,mitochondrial proton-transporting ATP synthase complex, coupling factor F(o);GO:0031305,integral component of mitochondrial inner membrane;GO:0016020,membrane;GO:0005615,extracellular space;GO:0014069,postsynaptic density;GO:0070469,respirasome;GO:0005576,extracellular region;GO:0048471,perinuclear region of cytoplasm;GO:0030425,dendrite;GO:0031966,mitochondrial membrane;GO:0043025,neuronal cell body;GO:0043005,neuron projection	GO:0008137,NADH dehydrogenase (ubiquinone) activity;GO:0048039,ubiquinone binding;GO:0004129,cytochrome-c oxidase activity;GO:0020037,heme binding;GO:0046872,metal ion binding;GO:0009055,electron transfer activity;GO:0015453,oxidoreduction-driven active transmembrane transporter activity;GO:0015078,proton transmembrane transporter activity;GO:0044877,protein-containing complex binding;GO:0008121,ubiquinol-cytochrome-c reductase activity;GO:0005507,copper ion binding;GO:0035255,ionotropic glutamate receptor binding;GO:0019901,protein kinase binding;GO:0048019,receptor antagonist activity;GO:0005102,signaling receptor binding;GO:0003954,NADH dehydrogenase activity	GO:0009060,aerobic respiration;GO:0007568,aging;GO:0021549,cerebellum development;GO:0015990,electron transport coupled proton transport;GO:0001701,in utero embryonic development;GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly;GO:0045471,response to ethanol;GO:0001666,response to hypoxia;GO:0035094,response to nicotine;GO:0006123,mitochondrial electron transport, cytochrome c to oxygen;GO:0022904,respiratory electron transport chain;GO:0046688,response to copper ion;GO:0051602,response to electrical stimulus;GO:0006979,response to oxidative stress;GO:0008535,respiratory chain complex IV assembly;GO:0006754,ATP biosynthetic process;GO:0015986,ATP synthesis coupled proton transport;GO:0042407,cristae formation;GO:0042776,mitochondrial ATP synthesis coupled proton transport;GO:0055093,response to hyperoxia;GO:0031100,animal organ regeneration;GO:0042538,hyperosmotic salinity response;GO:0006122,mitochondrial electron transport, ubiquinol to cytochrome c;GO:0046686,response to cadmium ion;GO:0051592,response to calcium ion;GO:0033590,response to cobalamin;GO:0042493,response to drug;GO:0033762,response to glucagon;GO:0009408,response to heat;GO:0046689,response to mercury ion;GO:0009636,response to toxic substance;GO:0042773,ATP synthesis coupled electron transport;GO:0007595,lactation;GO:2001171,positive regulation of ATP biosynthetic process;GO:0010729,positive regulation of hydrogen peroxide biosynthetic process;GO:0010940,positive regulation of necrotic cell death;GO:0009409,response to cold;GO:0032147,activation of protein kinase activity;GO:0072522,purine-containing compound biosynthetic process;GO:0043610,regulation of carbohydrate utilization;GO:0072593,reactive oxygen species metabolic process;GO:0042220,response to cocaine;GO:0042542,response to hydrogen peroxide;GO:0006915,apoptotic process;GO:0006879,cellular iron ion homeostasis;GO:0007186,G protein-coupled receptor signaling pathway;GO:0030595,leukocyte chemotaxis;GO:0043066,negative regulation of apoptotic process;GO:1900118,negative regulation of execution phase of apoptosis;GO:0033194,response to hydroperoxide;GO:0014070,response to organic cyclic compound;GO:0071385,cellular response to glucocorticoid stimulus;GO:0009642,response to light intensity;GO:0010243,response to organonitrogen compound	hsa:4538,path:hsa00190,Oxidative phosphorylation;hsa:4538,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4538,path:hsa04714,Thermogenesis;hsa:4538,path:hsa05012,Parkinson disease;hsa:4512,path:hsa00190,Oxidative phosphorylation;hsa:4512,path:hsa04260,Cardiac muscle contraction;hsa:4512,path:hsa04714,Thermogenesis;hsa:4512,path:hsa05010,Alzheimer disease;hsa:4512,path:hsa05012,Parkinson disease;hsa:4512,path:hsa05016,Huntington disease;hsa:4512,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4514,path:hsa00190,Oxidative phosphorylation;hsa:4514,path:hsa04260,Cardiac muscle contraction;hsa:4514,path:hsa04714,Thermogenesis;hsa:4514,path:hsa05010,Alzheimer disease;hsa:4514,path:hsa05012,Parkinson disease;hsa:4514,path:hsa05016,Huntington disease;hsa:4514,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4508,path:hsa00190,Oxidative phosphorylation;hsa:4508,path:hsa04714,Thermogenesis;hsa:4508,path:hsa05010,Alzheimer disease;hsa:4508,path:hsa05012,Parkinson disease;hsa:4508,path:hsa05016,Huntington disease;hsa:4509,path:hsa00190,Oxidative phosphorylation;hsa:4509,path:hsa04714,Thermogenesis;hsa:4509,path:hsa05010,Alzheimer disease;hsa:4509,path:hsa05012,Parkinson disease;hsa:4509,path:hsa05016,Huntington disease;hsa:4519,path:hsa00190,Oxidative phosphorylation;hsa:4519,path:hsa04260,Cardiac muscle contraction;hsa:4519,path:hsa04714,Thermogenesis;hsa:4519,path:hsa05010,Alzheimer disease;hsa:4519,path:hsa05012,Parkinson disease;hsa:4519,path:hsa05016,Huntington disease;hsa:4519,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4513,path:hsa00190,Oxidative phosphorylation;hsa:4513,path:hsa04260,Cardiac muscle contraction;hsa:4513,path:hsa04714,Thermogenesis;hsa:4513,path:hsa05010,Alzheimer disease;hsa:4513,path:hsa05012,Parkinson disease;hsa:4513,path:hsa05016,Huntington disease;hsa:4513,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:4536,path:hsa00190,Oxidative phosphorylation;hsa:4536,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4536,path:hsa04714,Thermogenesis;hsa:4536,path:hsa05012,Parkinson disease;hsa:4541,path:hsa00190,Oxidative phosphorylation;hsa:4541,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4541,path:hsa04714,Thermogenesis;hsa:4541,path:hsa05012,Parkinson disease;hsa:4539,path:hsa00190,Oxidative phosphorylation;hsa:4539,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4539,path:hsa04714,Thermogenesis;hsa:4539,path:hsa05012,Parkinson disease;hsa:4535,path:hsa00190,Oxidative phosphorylation;hsa:4535,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4535,path:hsa04714,Thermogenesis;hsa:4535,path:hsa05012,Parkinson disease;hsa:4537,path:hsa00190,Oxidative phosphorylation;hsa:4537,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4537,path:hsa04714,Thermogenesis;hsa:4537,path:hsa05012,Parkinson disease;hsa:4540,path:hsa00190,Oxidative phosphorylation;hsa:4540,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4540,path:hsa04714,Thermogenesis;hsa:4540,path:hsa05012,Parkinson disease
EMD_HUMAN	P50402	EMD	Emerin	0.868161204	0.386467235	0.311030253	0.218184633	0.6273142195	0.264607443	0.6273142195	0.264607443	2.37073535191525	0.185284	0	0.421810051127017	0.184717	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005874,microtubule;GO:0005635,nuclear envelope;GO:0005637,nuclear inner membrane;GO:0031965,nuclear membrane;GO:0005640,nuclear outer membrane;GO:0005654,nucleoplasm;GO:0005819,spindle	GO:0003779,actin binding;GO:0048487,beta-tubulin binding;GO:0045296,cadherin binding	GO:0071363,cellular response to growth factor stimulus;GO:0007084,mitotic nuclear envelope reassembly;GO:0006936,muscle contraction;GO:0007517,muscle organ development;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0048147,negative regulation of fibroblast proliferation;GO:0071763,nuclear membrane organization;GO:0046827,positive regulation of protein export from nucleus;GO:0045048,protein insertion into ER membrane;GO:0060828,regulation of canonical Wnt signaling pathway;GO:0035914,skeletal muscle cell differentiation	hsa:2010,path:hsa05410,Hypertrophic cardiomyopathy (HCM);hsa:2010,path:hsa05412,Arrhythmogenic right ventricular cardiomyopathy (ARVC);hsa:2010,path:hsa05414,Dilated cardiomyopathy (DCM)
NUP98_HUMAN	P52948	NUP98	Nuclear pore complex protein Nup98-Nup96	0.366253769	0.06453085	0.586661594	0.259979828	0.2153923095	0.423320711	0.2153923095	0.423320711	0.50881590222974	0.233234	0	1.965347379313	0.233560	0	GO:0005829,cytosol;GO:0043657,host cell;GO:0043231,intracellular membrane-bounded organelle;GO:0016604,nuclear body;GO:0005635,nuclear envelope;GO:0042405,nuclear inclusion body;GO:0031965,nuclear membrane;GO:0034399,nuclear periphery;GO:0005643,nuclear pore;GO:0044615,nuclear pore nuclear basket;GO:0031080,nuclear pore outer ring;GO:0005654,nucleoplasm;GO:1990904,ribonucleoprotein complex	GO:0003729,mRNA binding;GO:0008139,nuclear localization sequence binding;GO:1990841,promoter-specific chromatin binding;GO:0008236,serine-type peptidase activity;GO:0017056,structural constituent of nuclear pore;GO:0003713,transcription coactivator activity;GO:0005215,transporter activity	GO:0075733,intracellular transport of virus;GO:0007084,mitotic nuclear envelope reassembly;GO:0007052,mitotic spindle organization;GO:0006406,mRNA export from nucleus;GO:0051292,nuclear pore complex assembly;GO:0006999,nuclear pore organization;GO:0006913,nucleocytoplasmic transport;GO:0048026,positive regulation of mRNA splicing, via spliceosome;GO:0006606,protein import into nucleus;GO:0016925,protein sumoylation;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription;GO:0051028,mRNA transport;GO:0015031,protein transport	hsa:4928,path:hsa03013,RNA transport;hsa:4928,path:hsa05164,Influenza A
RS8_HUMAN	P62241	RPS8	40S ribosomal protein S8	8.010071348	590.6177419	1.742336121	9.388959005	299.313906624	5.565647563	299.313906624	5.565647563	53.7788106839204	0.000211	1	0.018594684175472	0.000204	-1	GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0002181,cytoplasmic translation;GO:0000462,maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6202,path:hsa03010,Ribosome
RAB5C_HUMAN	P51148	RAB5C	Ras-related protein Rab-5C	10.23995021	33.81479302	1.742584861	1.648155718	22.027371615	1.6953702895	22.027371615	1.6953702895	12.9926611026647	0.009922	1	0.0769665268799253	0.009782	-1	GO:0035577,azurophil granule membrane;GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0030139,endocytic vesicle;GO:0012505,endomembrane system;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005811,lipid droplet;GO:0005765,lysosomal membrane;GO:0042470,melanosome;GO:0005886,plasma membrane	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0006897,endocytosis;GO:0006886,intracellular protein transport;GO:0043312,neutrophil degranulation;GO:0048227,plasma membrane to endosome transport;GO:0030100,regulation of endocytosis	hsa:5878,path:hsa04014,Ras signaling pathway;hsa:5878,path:hsa04144,Endocytosis;hsa:5878,path:hsa04145,Phagosome;hsa:5878,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:5878,path:hsa05132,Salmonella infection;hsa:5878,path:hsa05152,Tuberculosis;hsa:5878,path:hsa05146,Amoebiasis
NPL4_HUMAN	Q8TAT6	NPLOC4	Nuclear protein localization protein 4 homolog	2.137663753	0.665547646	1.238702721	2.768801057	1.4016056995	2.003751889	1.4016056995	2.003751889	0.699490644123355	0.404445	0	1.42961168730607	0.404641	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0042175,nuclear outer membrane-endoplasmic reticulum membrane network;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0036501,UFD1-NPL4 complex;GO:0034098,VCP-NPL4-UFD1 AAA ATPase complex	GO:0046872,metal ion binding;GO:0043130,ubiquitin binding;GO:0031625,ubiquitin protein ligase binding	GO:0070987,error-free translesion synthesis;GO:0007030,Golgi organization;GO:0039536,negative regulation of RIG-I signaling pathway;GO:0032480,negative regulation of type I interferon production;GO:0030970,retrograde protein transport, ER to cytosol;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:55666,path:hsa04141,Protein processing in endoplasmic reticulum
DOPD_HUMAN	P30046	DDT	D-dopachrome decarboxylase	1.096525551	1.082067025	1.287376823	2.722543167	1.089296288	2.004959995	1.089296288	2.004959995	0.543300759474754	0.264995	0	1.84060114505779	0.265306	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005615,extracellular space	GO:0005126,cytokine receptor binding;GO:0033981,D-dopachrome decarboxylase activity;GO:0004167,dopachrome isomerase activity;GO:0050178,phenylpyruvate tautomerase activity	GO:0042438,melanin biosynthetic process;GO:0010760,negative regulation of macrophage chemotaxis;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0050729,positive regulation of inflammatory response;GO:0032760,positive regulation of tumor necrosis factor production	
ARSA_HUMAN	P15289	ARSA	Arylsulfatase A	0.136814146	0.161462652	0.23849624	0.381974439	0.149138399	0.3102353395	0.149138399	0.3102353395	0.480726661380239	0.207530	0	2.08018418851338	0.207863	0	GO:0035578,azurophil granule lumen;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0043202,lysosomal lumen;GO:0005764,lysosome;GO:0001669,acrosomal vesicle;GO:0005768,endosome;GO:0005615,extracellular space;GO:0031232,extrinsic component of external side of plasma membrane;GO:0016021,integral component of membrane	GO:0004065,arylsulfatase activity;GO:0005509,calcium ion binding;GO:0004098,cerebroside-sulfatase activity;GO:0008484,sulfuric ester hydrolase activity;GO:0003824,catalytic activity	GO:0006687,glycosphingolipid metabolic process;GO:0043312,neutrophil degranulation;GO:0006914,autophagy;GO:0007339,binding of sperm to zona pellucida;GO:0007417,central nervous system development;GO:0043627,response to estrogen;GO:0045471,response to ethanol;GO:0051597,response to methylmercury;GO:0007584,response to nutrient;GO:0009268,response to pH	hsa:410,path:hsa00600,Sphingolipid metabolism;hsa:410,path:hsa04142,Lysosome
GMPPB_HUMAN	Q9Y5P6	GMPPB	Mannose-1-phosphate guanyltransferase beta	0.952307325	0.609726601	1.705428918	0.832964891	0.781016963	1.2691969045	0.781016963	1.2691969045	0.615363116811005	0.330808	0	1.62505677165427	0.331072	0	GO:0005737,cytoplasm	GO:0005525,GTP binding;GO:0004475,mannose-1-phosphate guanylyltransferase activity	GO:0009298,GDP-mannose biosynthetic process	hsa:29925,path:hsa00051,Fructose and mannose metabolism;hsa:29925,path:hsa00520,Amino sugar and nucleotide sugar metabolism
NRBP_HUMAN	Q9UHY1	NRBP1	Nuclear receptor-binding protein	0.04392822	0.034871327	0.157838873	0.05432053	0.0393997735	0.1060797015	0.0393997735	0.1060797015	0.371416707842075	0.113281	0	2.69239368850686	0.113592	0	GO:0005938,cell cortex;GO:0005737,cytoplasm;GO:0012505,endomembrane system;GO:0030027,lamellipodium;GO:0016020,membrane;GO:0005654,nucleoplasm	GO:0005524,ATP binding;GO:0042803,protein homodimerization activity;GO:0004672,protein kinase activity	GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0035556,intracellular signal transduction;GO:0006468,protein phosphorylation;GO:0006367,transcription initiation from RNA polymerase II promoter	
PEA15_HUMAN	Q15121	PEA15	Astrocytic phosphoprotein PEA-15	0.521459847	1.678939829	0.150743747	0.238807736	1.100199838	0.1947757415	1.100199838	0.1947757415	5.64854652600565	0.051849	0	0.177036693492042	0.051452	0	GO:0005829,cytosol;GO:0005875,microtubule associated complex;GO:0005654,nucleoplasm		GO:0000187,activation of MAPK activity;GO:0006915,apoptotic process;GO:0008643,carbohydrate transport;GO:0000165,MAPK cascade;GO:1902042,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0046325,negative regulation of glucose import;GO:1902043,positive regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0043278,response to morphine;GO:0042981,regulation of apoptotic process	
SNTB2_HUMAN	Q13425	SNTB2	Beta-2-syntrophin	0.732810483	0.681642277	0.954210425	3.609196922	0.70722638	2.2817036735	0.70722638	2.2817036735	0.30995540227849	0.068678	0	3.22627059457256	0.068934	0	GO:0005737,cytoplasm;GO:0016010,dystrophin-associated glycoprotein complex;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0016020,membrane;GO:0005874,microtubule;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0045202,synapse;GO:0030658,transport vesicle membrane;GO:0005856,cytoskeleton	GO:0003779,actin binding;GO:0005516,calmodulin binding;GO:0003723,RNA binding;GO:0005198,structural molecule activity		
RBM8A_HUMAN	Q9Y5S9	RBM8A	RNA-binding protein 8A	1.768111235	0.279829701	0.064365307	2.55E-05	1.023970468	0.0321954035	1.023970468	0.0321954035	31.8048651882869	0.001022	1	0.0314417305050637	0.000998	-1	GO:0071013,catalytic step 2 spliceosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0035145,exon-exon junction complex;GO:0043025,neuronal cell body;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0071006,U2-type catalytic step 1 spliceosome;GO:0005681,spliceosomal complex	GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0006417,regulation of translation;GO:0006405,RNA export from nucleus;GO:0008380,RNA splicing;GO:0006397,mRNA processing;GO:0051028,mRNA transport	hsa:9939,path:hsa03040,Spliceosome;hsa:9939,path:hsa03013,RNA transport;hsa:9939,path:hsa03015,mRNA surveillance pathway
SAP18_HUMAN	O00422	SAP18	Histone deacetylase complex subunit SAP18	0.686537749	2.55E-05	0.051839456	2.55E-05	0.3432816245	0.025932478	0.3432816245	0.025932478	13.2375172361083	0.009513	1	0.0755428666995253	0.009377	-1	GO:0061574,ASAP complex;GO:0005829,cytosol;GO:0000118,histone deacetylase complex;GO:0016604,nuclear body;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003723,RNA binding;GO:0003714,transcription corepressor activity;GO:0008134,transcription factor binding	GO:0006397,mRNA processing;GO:0048025,negative regulation of mRNA splicing, via spliceosome;GO:0045892,negative regulation of transcription, DNA-templated;GO:0043065,positive regulation of apoptotic process;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0006357,regulation of transcription by RNA polymerase II;GO:0008380,RNA splicing	hsa:10284,path:hsa03013,RNA transport;hsa:10284,path:hsa03015,mRNA surveillance pathway
SART3_HUMAN	Q15020	SART3	Squamous cell carcinoma antigen recognized by T-cells 3	1.440065667	0.621023299	1.751756148	1.402017071	1.030544483	1.5768866095	1.030544483	1.5768866095	0.653531126963381	0.364777	0	1.53014899940035	0.365012	0	GO:0061574,ASAP complex;GO:0015030,Cajal body;GO:0005737,cytoplasm;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0042393,histone binding;GO:0003723,RNA binding;GO:0030621,U4 snRNA binding;GO:0017070,U6 snRNA binding;GO:0030624,U6atac snRNA binding;GO:1990381,ubiquitin-specific protease binding	GO:0000398,mRNA splicing, via spliceosome;GO:0006334,nucleosome assembly;GO:1903586,positive regulation of histone deubiquitination;GO:0010468,regulation of gene expression;GO:0000387,spliceosomal snRNP assembly;GO:0000244,spliceosomal tri-snRNP complex assembly;GO:0006396,RNA processing;GO:0000902,cell morphogenesis;GO:0071425,hematopoietic stem cell proliferation;GO:0048872,homeostasis of number of cells	
SMRC1_HUMAN	Q92922	SMARCC1	SWI/SNF complex subunit SMARCC1	0.095972187	0.039678514	0.055245217	2.55E-05	0.0678253505	0.0276353585	0.0678253505	0.0276353585	2.45429602442103	0.177586	0	0.407448812225452	0.177016	0	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0071565,nBAF complex;GO:0071564,npBAF complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0016514,SWI/SNF complex;GO:0001741,XY body	GO:0003682,chromatin binding;GO:0042393,histone binding;GO:0047485,protein N-terminus binding;GO:0003713,transcription coactivator activity	GO:0009887,animal organ morphogenesis;GO:0043044,ATP-dependent chromatin remodeling;GO:0006338,chromatin remodeling;GO:0008286,insulin receptor signaling pathway;GO:0032435,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0007399,nervous system development;GO:0006337,nucleosome disassembly;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0030850,prostate gland development;GO:0006357,regulation of transcription by RNA polymerase II	hsa:6599,path:hsa04714,Thermogenesis;hsa:6599,path:hsa05225,Hepatocellular carcinoma
KHDR3_HUMAN	O75525	KHDRBS3	KH domain-containing, RNA-binding, signal transduction-associated protein 3	0.165874318	0.083424365	0.271185721	0.245295535	0.1246493415	0.258240628	0.1246493415	0.258240628	0.482686796672443	0.209314	0	2.07173680095213	0.209647	0	GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0042802,identical protein binding;GO:0003729,mRNA binding;GO:0019904,protein domain specific binding;GO:0003723,RNA binding;GO:0017124,SH3 domain binding	GO:0006397,mRNA processing;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0048024,regulation of mRNA splicing, via spliceosome;GO:0016032,viral process	
DRB1_HUMAN	P01911	HLA-DRB1	HLA class II histocompatibility antigen, DRB1 beta chain	6.312420067	24.3726654	12.42535683	10.93255386	15.3425427335	11.678955345	15.3425427335	11.678955345	1.31369136025239	0.345383	0	0.761213805811949	0.345009	0	GO:0009986,cell surface;GO:0031901,early endosome membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0000139,Golgi membrane;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0042612,MHC class I protein complex;GO:0032398,MHC class Ib protein complex;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0030667,secretory granule membrane;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0030666,endocytic vesicle membrane;GO:0001772,immunological synapse;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0042613,MHC class II protein complex;GO:0032588,trans-Golgi network membrane;GO:0030658,transport vesicle membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0010008,endosome membrane;GO:0005882,intermediate filament;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0005797,Golgi medial cisterna;GO:0042824,MHC class I peptide loading complex;GO:0035577,azurophil granule membrane;GO:0033106,cis-Golgi network membrane;GO:0005769,early endosome;GO:0031527,filopodium membrane;GO:0005771,multivesicular body	GO:0030881,beta-2-microglobulin binding;GO:0042288,MHC class I protein binding;GO:0046703,natural killer cell lectin-like receptor binding;GO:0042605,peptide antigen binding;GO:0005102,signaling receptor binding;GO:0042608,T cell receptor binding;GO:0051087,chaperone binding;GO:0046977,TAP binding;GO:0023026,MHC class II protein complex binding;GO:0032395,MHC class II receptor activity;GO:0030247,polysaccharide binding;GO:0042609,CD4 receptor binding;GO:0005200,structural constituent of cytoskeleton;GO:0042610,CD8 receptor binding;GO:0003723,RNA binding;GO:0062061,TAP complex binding;GO:0071889,14-3-3 protein binding;GO:0046978,TAP1 binding;GO:0046979,TAP2 binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:1990405,protein antigen binding;GO:0015643,toxic substance binding;GO:0008134,transcription factor binding;GO:0031625,ubiquitin protein ligase binding;GO:0046872,metal ion binding	GO:0002250,adaptive immune response;GO:0019731,antibacterial humoral response;GO:0002476,antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0002477,antigen processing and presentation of exogenous peptide antigen via MHC class Ib;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0036037,CD8-positive, alpha-beta T cell activation;GO:0050830,defense response to Gram-positive bacterium;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0002519,natural killer cell tolerance induction;GO:0045953,negative regulation of natural killer cell mediated cytotoxicity;GO:0001815,positive regulation of antibody-dependent cellular cytotoxicity;GO:2001187,positive regulation of CD8-positive, alpha-beta T cell activation;GO:2000566,positive regulation of CD8-positive, alpha-beta T cell proliferation;GO:0002639,positive regulation of immunoglobulin production;GO:0032736,positive regulation of interleukin-13 production;GO:0032753,positive regulation of interleukin-4 production;GO:0002729,positive regulation of natural killer cell cytokine production;GO:0045954,positive regulation of natural killer cell mediated cytotoxicity;GO:0002717,positive regulation of natural killer cell mediated immunity;GO:0032819,positive regulation of natural killer cell proliferation;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:0032759,positive regulation of TRAIL production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0042270,protection from natural killer cell mediated cytotoxicity;GO:0050776,regulation of immune response;GO:0002715,regulation of natural killer cell mediated immunity;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process;GO:0002486,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006952,defense response;GO:0016045,detection of bacterium;GO:0006955,immune response;GO:0043312,neutrophil degranulation;GO:2001198,regulation of dendritic cell differentiation;GO:0032655,regulation of interleukin-12 production;GO:0032675,regulation of interleukin-6 production;GO:0002667,regulation of T cell anergy;GO:0002491,antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002504,antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0050890,cognition;GO:0002469,myeloid dendritic cell antigen processing and presentation;GO:0002503,peptide antigen assembly with MHC class II protein complex;GO:2000516,positive regulation of CD4-positive, alpha-beta T cell activation;GO:0032831,positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0043382,positive regulation of memory T cell differentiation;GO:0045622,regulation of T-helper cell differentiation;GO:0050852,T cell receptor signaling pathway;GO:0002399,MHC class II protein complex assembly;GO:2001190,positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0042102,positive regulation of T cell proliferation;GO:0032729,positive regulation of interferon-gamma production;GO:0050870,positive regulation of T cell activation;GO:0008544,epidermis development;GO:0006959,humoral immune response;GO:0002437,inflammatory response to antigenic stimulus;GO:0030225,macrophage differentiation;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0032689,negative regulation of interferon-gamma production;GO:0042130,negative regulation of T cell proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0033674,positive regulation of kinase activity;GO:0043410,positive regulation of MAPK cascade;GO:0045657,positive regulation of monocyte differentiation;GO:0001934,positive regulation of protein phosphorylation;GO:0002842,positive regulation of T cell mediated immune response to tumor cell;GO:0045893,positive regulation of transcription, DNA-templated;GO:0046598,positive regulation of viral entry into host cell;GO:0051262,protein tetramerization;GO:0032653,regulation of interleukin-10 production;GO:0032673,regulation of interleukin-4 production;GO:0007165,signal transduction;GO:0042088,T-helper 1 type immune response;GO:0002587,negative regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0045580,regulation of T cell differentiation;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002485,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent;GO:0042590,antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:2000568,positive regulation of memory T cell activation;GO:0002726,positive regulation of T cell cytokine production;GO:0016567,protein ubiquitination;GO:0001913,T cell mediated cytotoxicity;GO:0002419,T cell mediated cytotoxicity directed against tumor cell target;GO:0002728,negative regulation of natural killer cell cytokine production;GO:0043322,negative regulation of natural killer cell degranulation;GO:1901215,negative regulation of neuron death;GO:0002725,negative regulation of T cell cytokine production;GO:0043323,positive regulation of natural killer cell degranulation;GO:0071346,cellular response to interferon-gamma;GO:0006968,cellular defense response;GO:0002767,immune response-inhibiting cell surface receptor signaling pathway;GO:0016525,negative regulation of angiogenesis;GO:2001199,negative regulation of dendritic cell differentiation;GO:0070317,negative regulation of G0 to G1 transition;GO:0050777,negative regulation of immune response;GO:0051898,negative regulation of protein kinase B signaling;GO:0001915,negative regulation of T cell mediated cytotoxicity;GO:0002451,peripheral B cell tolerance induction;GO:2000774,positive regulation of cellular senescence;GO:2000353,positive regulation of endothelial cell apoptotic process;GO:0032735,positive regulation of interleukin-12 production;GO:0060907,positive regulation of macrophage cytokine production;GO:0045591,positive regulation of regulatory T cell differentiation;GO:0002666,positive regulation of T cell tolerance induction;GO:0002645,positive regulation of tolerance induction;GO:0070207,protein homotrimerization;GO:0019882,antigen processing and presentation;GO:0002344,B cell affinity maturation;GO:0046635,positive regulation of alpha-beta T cell activation;GO:0002579,positive regulation of antigen processing and presentation;GO:0002827,positive regulation of T-helper 1 type immune response	hsa:3133,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3133,path:hsa04144,Endocytosis;hsa:3133,path:hsa04145,Phagosome;hsa:3133,path:hsa04218,Cellular senescence;hsa:3133,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3133,path:hsa04612,Antigen processing and presentation;hsa:3133,path:hsa05203,Viral carcinogenesis;hsa:3133,path:hsa05320,Autoimmune thyroid disease;hsa:3133,path:hsa05330,Allograft rejection;hsa:3133,path:hsa05332,Graft-versus-host disease;hsa:3133,path:hsa05416,Viral myocarditis;hsa:3133,path:hsa04940,Type I diabetes mellitus;hsa:3133,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3133,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3133,path:hsa05168,Herpes simplex virus 1 infection;hsa:3133,path:hsa05163,Human cytomegalovirus infection;hsa:3133,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3133,path:hsa05169,Epstein-Barr virus infection;hsa:3133,path:hsa05165,Human papillomavirus infection;hsa:3106,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3106,path:hsa04144,Endocytosis;hsa:3106,path:hsa04145,Phagosome;hsa:3106,path:hsa04218,Cellular senescence;hsa:3106,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3106,path:hsa04612,Antigen processing and presentation;hsa:3106,path:hsa05203,Viral carcinogenesis;hsa:3106,path:hsa05320,Autoimmune thyroid disease;hsa:3106,path:hsa05330,Allograft rejection;hsa:3106,path:hsa05332,Graft-versus-host disease;hsa:3106,path:hsa05416,Viral myocarditis;hsa:3106,path:hsa04940,Type I diabetes mellitus;hsa:3106,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3106,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3106,path:hsa05168,Herpes simplex virus 1 infection;hsa:3106,path:hsa05163,Human cytomegalovirus infection;hsa:3106,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3106,path:hsa05169,Epstein-Barr virus infection;hsa:3106,path:hsa05165,Human papillomavirus infection;hsa:3122,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3122,path:hsa04145,Phagosome;hsa:3122,path:hsa04640,Hematopoietic cell lineage;hsa:3122,path:hsa04612,Antigen processing and presentation;hsa:3122,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3122,path:hsa04659,Th17 cell differentiation;hsa:3122,path:hsa04672,Intestinal immune network for IgA production;hsa:3122,path:hsa05310,Asthma;hsa:3122,path:hsa05322,Systemic lupus erythematosus;hsa:3122,path:hsa05323,Rheumatoid arthritis;hsa:3122,path:hsa05320,Autoimmune thyroid disease;hsa:3122,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3122,path:hsa05330,Allograft rejection;hsa:3122,path:hsa05332,Graft-versus-host disease;hsa:3122,path:hsa05416,Viral myocarditis;hsa:3122,path:hsa04940,Type I diabetes mellitus;hsa:3122,path:hsa05150,Staphylococcus aureus infection;hsa:3122,path:hsa05152,Tuberculosis;hsa:3122,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3122,path:hsa05164,Influenza A;hsa:3122,path:hsa05168,Herpes simplex virus 1 infection;hsa:3122,path:hsa05169,Epstein-Barr virus infection;hsa:3122,path:hsa05145,Toxoplasmosis;hsa:3122,path:hsa05140,Leishmaniasis;hsa:3109,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3109,path:hsa04145,Phagosome;hsa:3109,path:hsa04640,Hematopoietic cell lineage;hsa:3109,path:hsa04612,Antigen processing and presentation;hsa:3109,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3109,path:hsa04659,Th17 cell differentiation;hsa:3109,path:hsa04672,Intestinal immune network for IgA production;hsa:3109,path:hsa05310,Asthma;hsa:3109,path:hsa05322,Systemic lupus erythematosus;hsa:3109,path:hsa05323,Rheumatoid arthritis;hsa:3109,path:hsa05320,Autoimmune thyroid disease;hsa:3109,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3109,path:hsa05330,Allograft rejection;hsa:3109,path:hsa05332,Graft-versus-host disease;hsa:3109,path:hsa05416,Viral myocarditis;hsa:3109,path:hsa04940,Type I diabetes mellitus;hsa:3109,path:hsa05150,Staphylococcus aureus infection;hsa:3109,path:hsa05152,Tuberculosis;hsa:3109,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3109,path:hsa05164,Influenza A;hsa:3109,path:hsa05168,Herpes simplex virus 1 infection;hsa:3109,path:hsa05169,Epstein-Barr virus infection;hsa:3109,path:hsa05145,Toxoplasmosis;hsa:3109,path:hsa05140,Leishmaniasis;hsa:3115,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3115,path:hsa04145,Phagosome;hsa:3115,path:hsa04640,Hematopoietic cell lineage;hsa:3115,path:hsa04612,Antigen processing and presentation;hsa:3115,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3115,path:hsa04659,Th17 cell differentiation;hsa:3115,path:hsa04672,Intestinal immune network for IgA production;hsa:3115,path:hsa05310,Asthma;hsa:3115,path:hsa05322,Systemic lupus erythematosus;hsa:3115,path:hsa05323,Rheumatoid arthritis;hsa:3115,path:hsa05320,Autoimmune thyroid disease;hsa:3115,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3115,path:hsa05330,Allograft rejection;hsa:3115,path:hsa05332,Graft-versus-host disease;hsa:3115,path:hsa05416,Viral myocarditis;hsa:3115,path:hsa04940,Type I diabetes mellitus;hsa:3115,path:hsa05150,Staphylococcus aureus infection;hsa:3115,path:hsa05152,Tuberculosis;hsa:3115,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3115,path:hsa05164,Influenza A;hsa:3115,path:hsa05168,Herpes simplex virus 1 infection;hsa:3115,path:hsa05169,Epstein-Barr virus infection;hsa:3115,path:hsa05145,Toxoplasmosis;hsa:3115,path:hsa05140,Leishmaniasis;hsa:3123,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3123,path:hsa04145,Phagosome;hsa:3123,path:hsa04640,Hematopoietic cell lineage;hsa:3123,path:hsa04612,Antigen processing and presentation;hsa:3123,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3123,path:hsa04659,Th17 cell differentiation;hsa:3123,path:hsa04672,Intestinal immune network for IgA production;hsa:3123,path:hsa05310,Asthma;hsa:3123,path:hsa05322,Systemic lupus erythematosus;hsa:3123,path:hsa05323,Rheumatoid arthritis;hsa:3123,path:hsa05320,Autoimmune thyroid disease;hsa:3123,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3123,path:hsa05330,Allograft rejection;hsa:3123,path:hsa05332,Graft-versus-host disease;hsa:3123,path:hsa05416,Viral myocarditis;hsa:3123,path:hsa04940,Type I diabetes mellitus;hsa:3123,path:hsa05150,Staphylococcus aureus infection;hsa:3123,path:hsa05152,Tuberculosis;hsa:3123,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3123,path:hsa05164,Influenza A;hsa:3123,path:hsa05168,Herpes simplex virus 1 infection;hsa:3123,path:hsa05169,Epstein-Barr virus infection;hsa:3123,path:hsa05145,Toxoplasmosis;hsa:3123,path:hsa05140,Leishmaniasis;hsa:3111,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3111,path:hsa04145,Phagosome;hsa:3111,path:hsa04640,Hematopoietic cell lineage;hsa:3111,path:hsa04612,Antigen processing and presentation;hsa:3111,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3111,path:hsa04659,Th17 cell differentiation;hsa:3111,path:hsa04672,Intestinal immune network for IgA production;hsa:3111,path:hsa05310,Asthma;hsa:3111,path:hsa05322,Systemic lupus erythematosus;hsa:3111,path:hsa05323,Rheumatoid arthritis;hsa:3111,path:hsa05320,Autoimmune thyroid disease;hsa:3111,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3111,path:hsa05330,Allograft rejection;hsa:3111,path:hsa05332,Graft-versus-host disease;hsa:3111,path:hsa05416,Viral myocarditis;hsa:3111,path:hsa04940,Type I diabetes mellitus;hsa:3111,path:hsa05150,Staphylococcus aureus infection;hsa:3111,path:hsa05152,Tuberculosis;hsa:3111,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3111,path:hsa05164,Influenza A;hsa:3111,path:hsa05168,Herpes simplex virus 1 infection;hsa:3111,path:hsa05169,Epstein-Barr virus infection;hsa:3111,path:hsa05145,Toxoplasmosis;hsa:3111,path:hsa05140,Leishmaniasis;hsa:3112,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3112,path:hsa04145,Phagosome;hsa:3112,path:hsa04640,Hematopoietic cell lineage;hsa:3112,path:hsa04612,Antigen processing and presentation;hsa:3112,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3112,path:hsa04659,Th17 cell differentiation;hsa:3112,path:hsa04672,Intestinal immune network for IgA production;hsa:3112,path:hsa05310,Asthma;hsa:3112,path:hsa05322,Systemic lupus erythematosus;hsa:3112,path:hsa05323,Rheumatoid arthritis;hsa:3112,path:hsa05320,Autoimmune thyroid disease;hsa:3112,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3112,path:hsa05330,Allograft rejection;hsa:3112,path:hsa05332,Graft-versus-host disease;hsa:3112,path:hsa05416,Viral myocarditis;hsa:3112,path:hsa04940,Type I diabetes mellitus;hsa:3112,path:hsa05150,Staphylococcus aureus infection;hsa:3112,path:hsa05152,Tuberculosis;hsa:3112,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3112,path:hsa05164,Influenza A;hsa:3112,path:hsa05168,Herpes simplex virus 1 infection;hsa:3112,path:hsa05169,Epstein-Barr virus infection;hsa:3112,path:hsa05145,Toxoplasmosis;hsa:3112,path:hsa05140,Leishmaniasis;hsa:3105,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3105,path:hsa04144,Endocytosis;hsa:3105,path:hsa04145,Phagosome;hsa:3105,path:hsa04218,Cellular senescence;hsa:3105,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3105,path:hsa04612,Antigen processing and presentation;hsa:3105,path:hsa05203,Viral carcinogenesis;hsa:3105,path:hsa05320,Autoimmune thyroid disease;hsa:3105,path:hsa05330,Allograft rejection;hsa:3105,path:hsa05332,Graft-versus-host disease;hsa:3105,path:hsa05416,Viral myocarditis;hsa:3105,path:hsa04940,Type I diabetes mellitus;hsa:3105,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3105,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3105,path:hsa05168,Herpes simplex virus 1 infection;hsa:3105,path:hsa05163,Human cytomegalovirus infection;hsa:3105,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3105,path:hsa05169,Epstein-Barr virus infection;hsa:3105,path:hsa05165,Human papillomavirus infection;hsa:3134,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3134,path:hsa04144,Endocytosis;hsa:3134,path:hsa04145,Phagosome;hsa:3134,path:hsa04218,Cellular senescence;hsa:3134,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3134,path:hsa04612,Antigen processing and presentation;hsa:3134,path:hsa05203,Viral carcinogenesis;hsa:3134,path:hsa05320,Autoimmune thyroid disease;hsa:3134,path:hsa05330,Allograft rejection;hsa:3134,path:hsa05332,Graft-versus-host disease;hsa:3134,path:hsa05416,Viral myocarditis;hsa:3134,path:hsa04940,Type I diabetes mellitus;hsa:3134,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3134,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3134,path:hsa05168,Herpes simplex virus 1 infection;hsa:3134,path:hsa05163,Human cytomegalovirus infection;hsa:3134,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3134,path:hsa05169,Epstein-Barr virus infection;hsa:3134,path:hsa05165,Human papillomavirus infection;hsa:3119,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3119,path:hsa04145,Phagosome;hsa:3119,path:hsa04640,Hematopoietic cell lineage;hsa:3119,path:hsa04612,Antigen processing and presentation;hsa:3119,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3119,path:hsa04659,Th17 cell differentiation;hsa:3119,path:hsa04672,Intestinal immune network for IgA production;hsa:3119,path:hsa05310,Asthma;hsa:3119,path:hsa05322,Systemic lupus erythematosus;hsa:3119,path:hsa05323,Rheumatoid arthritis;hsa:3119,path:hsa05320,Autoimmune thyroid disease;hsa:3119,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3119,path:hsa05330,Allograft rejection;hsa:3119,path:hsa05332,Graft-versus-host disease;hsa:3119,path:hsa05416,Viral myocarditis;hsa:3119,path:hsa04940,Type I diabetes mellitus;hsa:3119,path:hsa05150,Staphylococcus aureus infection;hsa:3119,path:hsa05152,Tuberculosis;hsa:3119,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3119,path:hsa05164,Influenza A;hsa:3119,path:hsa05168,Herpes simplex virus 1 infection;hsa:3119,path:hsa05169,Epstein-Barr virus infection;hsa:3119,path:hsa05145,Toxoplasmosis;hsa:3119,path:hsa05140,Leishmaniasis;hsa:3113,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3113,path:hsa04145,Phagosome;hsa:3113,path:hsa04640,Hematopoietic cell lineage;hsa:3113,path:hsa04612,Antigen processing and presentation;hsa:3113,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3113,path:hsa04659,Th17 cell differentiation;hsa:3113,path:hsa04672,Intestinal immune network for IgA production;hsa:3113,path:hsa05310,Asthma;hsa:3113,path:hsa05322,Systemic lupus erythematosus;hsa:3113,path:hsa05323,Rheumatoid arthritis;hsa:3113,path:hsa05320,Autoimmune thyroid disease;hsa:3113,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3113,path:hsa05330,Allograft rejection;hsa:3113,path:hsa05332,Graft-versus-host disease;hsa:3113,path:hsa05416,Viral myocarditis;hsa:3113,path:hsa04940,Type I diabetes mellitus;hsa:3113,path:hsa05150,Staphylococcus aureus infection;hsa:3113,path:hsa05152,Tuberculosis;hsa:3113,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3113,path:hsa05164,Influenza A;hsa:3113,path:hsa05168,Herpes simplex virus 1 infection;hsa:3113,path:hsa05169,Epstein-Barr virus infection;hsa:3113,path:hsa05145,Toxoplasmosis;hsa:3113,path:hsa05140,Leishmaniasis;hsa:3125,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3125,path:hsa04145,Phagosome;hsa:3125,path:hsa04640,Hematopoietic cell lineage;hsa:3125,path:hsa04612,Antigen processing and presentation;hsa:3125,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3125,path:hsa04659,Th17 cell differentiation;hsa:3125,path:hsa04672,Intestinal immune network for IgA production;hsa:3125,path:hsa05310,Asthma;hsa:3125,path:hsa05322,Systemic lupus erythematosus;hsa:3125,path:hsa05323,Rheumatoid arthritis;hsa:3125,path:hsa05320,Autoimmune thyroid disease;hsa:3125,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3125,path:hsa05330,Allograft rejection;hsa:3125,path:hsa05332,Graft-versus-host disease;hsa:3125,path:hsa05416,Viral myocarditis;hsa:3125,path:hsa04940,Type I diabetes mellitus;hsa:3125,path:hsa05150,Staphylococcus aureus infection;hsa:3125,path:hsa05152,Tuberculosis;hsa:3125,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3125,path:hsa05164,Influenza A;hsa:3125,path:hsa05168,Herpes simplex virus 1 infection;hsa:3125,path:hsa05169,Epstein-Barr virus infection;hsa:3125,path:hsa05145,Toxoplasmosis;hsa:3125,path:hsa05140,Leishmaniasis;hsa:3126,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3126,path:hsa04145,Phagosome;hsa:3126,path:hsa04640,Hematopoietic cell lineage;hsa:3126,path:hsa04612,Antigen processing and presentation;hsa:3126,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3126,path:hsa04659,Th17 cell differentiation;hsa:3126,path:hsa04672,Intestinal immune network for IgA production;hsa:3126,path:hsa05310,Asthma;hsa:3126,path:hsa05322,Systemic lupus erythematosus;hsa:3126,path:hsa05323,Rheumatoid arthritis;hsa:3126,path:hsa05320,Autoimmune thyroid disease;hsa:3126,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3126,path:hsa05330,Allograft rejection;hsa:3126,path:hsa05332,Graft-versus-host disease;hsa:3126,path:hsa05416,Viral myocarditis;hsa:3126,path:hsa04940,Type I diabetes mellitus;hsa:3126,path:hsa05150,Staphylococcus aureus infection;hsa:3126,path:hsa05152,Tuberculosis;hsa:3126,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3126,path:hsa05164,Influenza A;hsa:3126,path:hsa05168,Herpes simplex virus 1 infection;hsa:3126,path:hsa05169,Epstein-Barr virus infection;hsa:3126,path:hsa05145,Toxoplasmosis;hsa:3126,path:hsa05140,Leishmaniasis;hsa:3107,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3107,path:hsa04144,Endocytosis;hsa:3107,path:hsa04145,Phagosome;hsa:3107,path:hsa04218,Cellular senescence;hsa:3107,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3107,path:hsa04612,Antigen processing and presentation;hsa:3107,path:hsa05203,Viral carcinogenesis;hsa:3107,path:hsa05320,Autoimmune thyroid disease;hsa:3107,path:hsa05330,Allograft rejection;hsa:3107,path:hsa05332,Graft-versus-host disease;hsa:3107,path:hsa05416,Viral myocarditis;hsa:3107,path:hsa04940,Type I diabetes mellitus;hsa:3107,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3107,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3107,path:hsa05168,Herpes simplex virus 1 infection;hsa:3107,path:hsa05163,Human cytomegalovirus infection;hsa:3107,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3107,path:hsa05169,Epstein-Barr virus infection;hsa:3107,path:hsa05165,Human papillomavirus infection;hsa:3135,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3135,path:hsa04144,Endocytosis;hsa:3135,path:hsa04145,Phagosome;hsa:3135,path:hsa04218,Cellular senescence;hsa:3135,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3135,path:hsa04612,Antigen processing and presentation;hsa:3135,path:hsa05203,Viral carcinogenesis;hsa:3135,path:hsa05320,Autoimmune thyroid disease;hsa:3135,path:hsa05330,Allograft rejection;hsa:3135,path:hsa05332,Graft-versus-host disease;hsa:3135,path:hsa05416,Viral myocarditis;hsa:3135,path:hsa04940,Type I diabetes mellitus;hsa:3135,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3135,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3135,path:hsa05168,Herpes simplex virus 1 infection;hsa:3135,path:hsa05163,Human cytomegalovirus infection;hsa:3135,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3135,path:hsa05169,Epstein-Barr virus infection;hsa:3135,path:hsa05165,Human papillomavirus infection;hsa:3127,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3127,path:hsa04145,Phagosome;hsa:3127,path:hsa04640,Hematopoietic cell lineage;hsa:3127,path:hsa04612,Antigen processing and presentation;hsa:3127,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3127,path:hsa04659,Th17 cell differentiation;hsa:3127,path:hsa04672,Intestinal immune network for IgA production;hsa:3127,path:hsa05310,Asthma;hsa:3127,path:hsa05322,Systemic lupus erythematosus;hsa:3127,path:hsa05323,Rheumatoid arthritis;hsa:3127,path:hsa05320,Autoimmune thyroid disease;hsa:3127,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3127,path:hsa05330,Allograft rejection;hsa:3127,path:hsa05332,Graft-versus-host disease;hsa:3127,path:hsa05416,Viral myocarditis;hsa:3127,path:hsa04940,Type I diabetes mellitus;hsa:3127,path:hsa05150,Staphylococcus aureus infection;hsa:3127,path:hsa05152,Tuberculosis;hsa:3127,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3127,path:hsa05164,Influenza A;hsa:3127,path:hsa05168,Herpes simplex virus 1 infection;hsa:3127,path:hsa05169,Epstein-Barr virus infection;hsa:3127,path:hsa05145,Toxoplasmosis;hsa:3127,path:hsa05140,Leishmaniasis;hsa:3118,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3118,path:hsa04145,Phagosome;hsa:3118,path:hsa04640,Hematopoietic cell lineage;hsa:3118,path:hsa04612,Antigen processing and presentation;hsa:3118,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3118,path:hsa04659,Th17 cell differentiation;hsa:3118,path:hsa04672,Intestinal immune network for IgA production;hsa:3118,path:hsa05310,Asthma;hsa:3118,path:hsa05322,Systemic lupus erythematosus;hsa:3118,path:hsa05323,Rheumatoid arthritis;hsa:3118,path:hsa05320,Autoimmune thyroid disease;hsa:3118,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3118,path:hsa05330,Allograft rejection;hsa:3118,path:hsa05332,Graft-versus-host disease;hsa:3118,path:hsa05416,Viral myocarditis;hsa:3118,path:hsa04940,Type I diabetes mellitus;hsa:3118,path:hsa05150,Staphylococcus aureus infection;hsa:3118,path:hsa05152,Tuberculosis;hsa:3118,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3118,path:hsa05164,Influenza A;hsa:3118,path:hsa05168,Herpes simplex virus 1 infection;hsa:3118,path:hsa05169,Epstein-Barr virus infection;hsa:3118,path:hsa05145,Toxoplasmosis;hsa:3118,path:hsa05140,Leishmaniasis;hsa:3117,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3117,path:hsa04145,Phagosome;hsa:3117,path:hsa04640,Hematopoietic cell lineage;hsa:3117,path:hsa04612,Antigen processing and presentation;hsa:3117,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3117,path:hsa04659,Th17 cell differentiation;hsa:3117,path:hsa04672,Intestinal immune network for IgA production;hsa:3117,path:hsa05310,Asthma;hsa:3117,path:hsa05322,Systemic lupus erythematosus;hsa:3117,path:hsa05323,Rheumatoid arthritis;hsa:3117,path:hsa05320,Autoimmune thyroid disease;hsa:3117,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3117,path:hsa05330,Allograft rejection;hsa:3117,path:hsa05332,Graft-versus-host disease;hsa:3117,path:hsa05416,Viral myocarditis;hsa:3117,path:hsa04940,Type I diabetes mellitus;hsa:3117,path:hsa05150,Staphylococcus aureus infection;hsa:3117,path:hsa05152,Tuberculosis;hsa:3117,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3117,path:hsa05164,Influenza A;hsa:3117,path:hsa05168,Herpes simplex virus 1 infection;hsa:3117,path:hsa05169,Epstein-Barr virus infection;hsa:3117,path:hsa05145,Toxoplasmosis;hsa:3117,path:hsa05140,Leishmaniasis
GOLM2_HUMAN	Q6P4E1	GOLM2	Protein GOLM2	0.186028	0.172698205	0.178066006	0.197799334	0.1793631025	0.18793267	0.1793631025	0.18793267	0.954400863351753	0.448872	0	1.04777776131521	0.448709	0	GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane			
USO1_HUMAN	O60763	USO1	General vesicular transport factor p115	8.166633031	4.335627978	8.209921936	7.746541372	6.2511305045	7.978231654	6.2511305045	7.978231654	0.78352331388697	0.472700	0	1.27628620907158	0.472822	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0012507,ER to Golgi transport vesicle membrane;GO:0001650,fibrillar center;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005795,Golgi stack;GO:0016020,membrane;GO:0005815,microtubule organizing center;GO:0048471,perinuclear region of cytoplasm;GO:0030133,transport vesicle	GO:0045296,cadherin binding;GO:0003723,RNA binding	GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030,Golgi organization;GO:0048211,Golgi vesicle docking;GO:0006886,intracellular protein transport;GO:0061025,membrane fusion;GO:1900076,regulation of cellular response to insulin stimulus;GO:0032252,secretory granule localization;GO:0007264,small GTPase mediated signal transduction;GO:0045056,transcytosis;GO:0048280,vesicle fusion with Golgi apparatus	
FLNA_HUMAN	P21333	FLNA	Filamin-A	208.4029521	248.5070154	179.7589543	481.4160422	228.45498375	330.58749825	228.45498375	330.58749825	0.69105754137513	0.397280	0	1.4470575026359	0.397483	0	GO:0015629,actin cytoskeleton;GO:0005884,actin filament;GO:0032432,actin filament bundle;GO:0097440,apical dendrite;GO:0044295,axonal growth cone;GO:0005903,brush border;GO:0005911,cell-cell junction;GO:0030863,cortical cytoskeleton;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043198,dendritic shaft;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0016020,membrane;GO:0031523,Myb complex;GO:0005730,nucleolus;GO:0005634,nucleus;GO:0043204,perikaryon;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0098794,postsynapse;GO:0005802,trans-Golgi network;GO:0030018,Z disc	GO:0051015,actin filament binding;GO:0045296,cadherin binding;GO:0034988,Fc-gamma receptor I complex binding;GO:0001664,G protein-coupled receptor binding;GO:0051020,GTPase binding;GO:0044325,ion channel binding;GO:0019900,kinase binding;GO:0031852,mu-type opioid receptor binding;GO:0015459,potassium channel regulator activity;GO:0042803,protein homodimerization activity;GO:0005080,protein kinase C binding;GO:0003723,RNA binding;GO:0046332,SMAD binding;GO:0031267,small GTPase binding;GO:0008134,transcription factor binding;GO:0003779,actin binding	GO:0051764,actin crosslink formation;GO:0031532,actin cytoskeleton reorganization;GO:0007195,adenylate cyclase-inhibiting dopamine receptor signaling pathway;GO:0001525,angiogenesis;GO:0001974,blood vessel remodeling;GO:0034329,cell junction assembly;GO:0045216,cell-cell junction organization;GO:0021987,cerebral cortex development;GO:0060271,cilium assembly;GO:0051220,cytoplasmic sequestering of protein;GO:0051607,defense response to virus;GO:0045022,early endosome to late endosome transport;GO:0001837,epithelial to mesenchymal transition;GO:0045184,establishment of protein localization;GO:0097368,establishment of Sertoli cell barrier;GO:0021943,formation of radial glial scaffolds;GO:0003007,heart morphogenesis;GO:0090307,mitotic spindle assembly;GO:0042789,mRNA transcription by RNA polymerase II;GO:0043066,negative regulation of apoptotic process;GO:0043433,negative regulation of DNA-binding transcription factor activity;GO:0010977,negative regulation of neuron projection development;GO:0042177,negative regulation of protein catabolic process;GO:0016479,negative regulation of transcription by RNA polymerase I;GO:0030168,platelet activation;GO:0070527,platelet aggregation;GO:0002576,platelet degranulation;GO:0032233,positive regulation of actin filament bundle assembly;GO:0048680,positive regulation of axon regeneration;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:2001046,positive regulation of integrin-mediated signaling pathway;GO:2000179,positive regulation of neural precursor cell proliferation;GO:2001224,positive regulation of neuron migration;GO:1901381,positive regulation of potassium ion transmembrane transport;GO:0042307,positive regulation of protein import into nucleus;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:1902396,protein localization to bicellular tight junction;GO:0034394,protein localization to cell surface;GO:0072659,protein localization to plasma membrane;GO:0050821,protein stabilization;GO:0043113,receptor clustering;GO:0030334,regulation of cell migration;GO:1905000,regulation of membrane repolarization during atrial cardiac muscle cell action potential;GO:1905031,regulation of membrane repolarization during cardiac muscle cell action potential;GO:0071526,semaphorin-plexin signaling pathway;GO:0050808,synapse organization;GO:0090042,tubulin deacetylation;GO:0044319,wound healing, spreading of cells	hsa:2316,path:hsa04010,MAPK signaling pathway;hsa:2316,path:hsa04510,Focal adhesion;hsa:2316,path:hsa05205,Proteoglycans in cancer;hsa:2316,path:hsa05132,Salmonella infection
RAB14_HUMAN	P61106	RAB14	Ras-related protein Rab-14	8.899430225	22.04235408	2.35808307	1.950195082	15.4708921525	2.154139076	15.4708921525	2.154139076	7.18193747324233	0.033654	1	0.139238193555108	0.033340	-1	GO:0005829,cytosol;GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0012505,endomembrane system;GO:0070062,extracellular exosome;GO:0000139,Golgi membrane;GO:0005795,Golgi stack;GO:0043231,intracellular membrane-bounded organelle;GO:0005770,late endosome;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0042175,nuclear outer membrane-endoplasmic reticulum membrane network;GO:0048471,perinuclear region of cytoplasm;GO:0045335,phagocytic vesicle;GO:0005886,plasma membrane;GO:0055037,recycling endosome;GO:0055038,recycling endosome membrane;GO:0005791,rough endoplasmic reticulum;GO:0070821,tertiary granule membrane;GO:0005802,trans-Golgi network;GO:0030140,trans-Golgi network transport vesicle	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0031489,myosin V binding	GO:0042742,defense response to bacterium;GO:0032456,endocytic recycling;GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0006895,Golgi to endosome transport;GO:0006886,intracellular protein transport;GO:0046907,intracellular transport;GO:0043312,neutrophil degranulation;GO:0090387,phagolysosome assembly involved in apoptotic cell clearance;GO:0090382,phagosome maturation;GO:0006661,phosphatidylinositol biosynthetic process;GO:0045995,regulation of embryonic development;GO:0032880,regulation of protein localization;GO:0016192,vesicle-mediated transport	hsa:51552,path:hsa04152,AMPK signaling pathway
CDN2A_HUMAN	P42771	CDKN2A	Cyclin-dependent kinase inhibitor 2A	0.006173934	1.093387951	2.55E-05	0.002431154	0.5497809425	0.001228327	0.5497809425	0.001228327	447.585164618216	0.000000	1	0.00223421167422514	0.000000	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus;GO:0035985,senescence-associated heterochromatin focus;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0032991,protein-containing complex	GO:0004861,cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0051059,NF-kappaB binding;GO:0019901,protein kinase binding;GO:0003723,RNA binding;GO:0097718,disordered domain specific binding;GO:0003677,DNA binding;GO:0097371,MDM2/MDM4 family protein binding;GO:0002039,p53 binding;GO:0019789,SUMO transferase activity;GO:0008134,transcription factor binding;GO:1990948,ubiquitin ligase inhibitor activity;GO:0055105,ubiquitin-protein transferase inhibitor activity	GO:0007050,cell cycle arrest;GO:0090398,cellular senescence;GO:0000082,G1/S transition of mitotic cell cycle;GO:0030308,negative regulation of cell growth;GO:0008285,negative regulation of cell population proliferation;GO:0001953,negative regulation of cell-matrix adhesion;GO:0045736,negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:2000134,negative regulation of G1/S transition of mitotic cell cycle;GO:0032088,negative regulation of NF-kappaB transcription factor activity;GO:0042326,negative regulation of phosphorylation;GO:0045892,negative regulation of transcription, DNA-templated;GO:2000774,positive regulation of cellular senescence;GO:2000111,positive regulation of macrophage apoptotic process;GO:0034393,positive regulation of smooth muscle cell apoptotic process;GO:0007265,Ras protein signal transduction;GO:0060260,regulation of transcription initiation from RNA polymerase II promoter;GO:0090399,replicative senescence;GO:0035986,senescence-associated heterochromatin focus assembly;GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:1990000,amyloid fibril formation;GO:0008637,apoptotic mitochondrial changes;GO:0000422,autophagy of mitochondrion;GO:0097193,intrinsic apoptotic signaling pathway;GO:0051882,mitochondrial depolarization;GO:0030889,negative regulation of B cell proliferation;GO:0033088,negative regulation of immature T cell proliferation in thymus;GO:0006469,negative regulation of protein kinase activity;GO:2000435,negative regulation of protein neddylation;GO:1903051,negative regulation of proteolysis involved in cellular protein catabolic process;GO:1904667,negative regulation of ubiquitin protein ligase activity;GO:2000059,negative regulation of ubiquitin-dependent protein catabolic process;GO:0051444,negative regulation of ubiquitin-protein transferase activity;GO:0043065,positive regulation of apoptotic process;GO:0071158,positive regulation of cell cycle arrest;GO:0043517,positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0010628,positive regulation of gene expression;GO:1900182,positive regulation of protein localization to nucleus;GO:0033235,positive regulation of protein sumoylation;GO:1901798,positive regulation of signal transduction by p53 class mediator;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0031648,protein destabilization;GO:0070534,protein K63-linked ubiquitination;GO:0000209,protein polyubiquitination;GO:0050821,protein stabilization;GO:1902510,regulation of apoptotic DNA fragmentation;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0046825,regulation of protein export from nucleus;GO:0031647,regulation of protein stability;GO:1903214,regulation of protein targeting to mitochondrion;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0006364,rRNA processing;GO:0048103,somatic stem cell division	hsa:1029,path:hsa04110,Cell cycle;hsa:1029,path:hsa04115,p53 signaling pathway;hsa:1029,path:hsa04218,Cellular senescence;hsa:1029,path:hsa05200,Pathways in cancer;hsa:1029,path:hsa05206,MicroRNAs in cancer;hsa:1029,path:hsa05203,Viral carcinogenesis;hsa:1029,path:hsa05212,Pancreatic cancer;hsa:1029,path:hsa05225,Hepatocellular carcinoma;hsa:1029,path:hsa05214,Glioma;hsa:1029,path:hsa05220,Chronic myeloid leukemia;hsa:1029,path:hsa05218,Melanoma;hsa:1029,path:hsa05219,Bladder cancer;hsa:1029,path:hsa05223,Non-small cell lung cancer;hsa:1029,path:hsa04934,Cushing syndrome;hsa:1029,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:1029,path:hsa05163,Human cytomegalovirus infection;hsa:1029,path:hsa01524,Platinum drug resistance;hsa:1029,path:hsa01522,Endocrine resistance
PSB1_HUMAN	P20618	PSMB1	Proteasome subunit beta type-1	6.625128523	16.45373304	3.7893903	3.548682091	11.5394307815	3.6690361955	11.5394307815	3.6690361955	3.14508502141595	0.128474	0	0.317956428265265	0.127917	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000502,proteasome complex;GO:0005839,proteasome core complex;GO:0019774,proteasome core complex, beta-subunit complex;GO:0034774,secretory granule lumen	GO:0004175,endopeptidase activity;GO:0004298,threonine-type endopeptidase activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0043312,neutrophil degranulation;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0016032,viral process;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5689,path:hsa03050,Proteasome
CP4F3_HUMAN	Q08477	CYP4F3	Cytochrome P450 4F3	0.53912129	0.894862341	1.490791226	1.741842586	0.7169918155	1.616316906	0.7169918155	1.616316906	0.443596062652332	0.174157	0	2.25430314692344	0.174492	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle	GO:0008391,arachidonic acid monooxygenase activity;GO:0070330,aromatase activity;GO:0102207,docosanoate omega-hydroxylase activity;GO:0020037,heme binding;GO:0005506,iron ion binding;GO:0050051,leukotriene-B4 20-monooxygenase activity;GO:0004497,monooxygenase activity;GO:0016705,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO:0019369,arachidonic acid metabolic process;GO:0006690,icosanoid metabolic process;GO:0036101,leukotriene B4 catabolic process;GO:0006691,leukotriene metabolic process;GO:0042361,menaquinone catabolic process;GO:0042376,phylloquinone catabolic process;GO:0042377,vitamin K catabolic process	hsa:4051,path:hsa00590,Arachidonic acid metabolism
MSH2_HUMAN	P43246	MSH2	DNA mismatch repair protein Msh2	0.163915684	0.099587611	0.144434047	0.278583631	0.1317516475	0.211508839	0.1317516475	0.211508839	0.62291319891364	0.337591	0	1.60536010754628	0.337850	0	GO:0000781,chromosome, telomeric region;GO:0016020,membrane;GO:0032300,mismatch repair complex;GO:0032301,MutSalpha complex;GO:0032302,MutSbeta complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005694,chromosome	GO:0005524,ATP binding;GO:0008094,ATPase activity, acting on DNA;GO:0019237,centromeric DNA binding;GO:0003682,chromatin binding;GO:0003684,damaged DNA binding;GO:0003677,DNA binding;GO:0000406,double-strand/single-strand DNA junction binding;GO:0019899,enzyme binding;GO:0032137,guanine/thymine mispair binding;GO:0008022,protein C-terminus binding;GO:0042803,protein homodimerization activity;GO:0019901,protein kinase binding;GO:0030983,mismatched DNA binding	GO:0030183,B cell differentiation;GO:0019724,B cell mediated immunity;GO:0007050,cell cycle arrest;GO:0008340,determination of adult lifespan;GO:0006310,DNA recombination;GO:0006281,DNA repair;GO:0006302,double-strand break repair;GO:0007281,germ cell development;GO:0001701,in utero embryonic development;GO:0031573,intra-S DNA damage checkpoint;GO:0042771,intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0045190,isotype switching;GO:0043570,maintenance of DNA repeat elements;GO:0008584,male gonad development;GO:0006298,mismatch repair;GO:0045910,negative regulation of DNA recombination;GO:0043524,negative regulation of neuron apoptotic process;GO:0006119,oxidative phosphorylation;GO:0051096,positive regulation of helicase activity;GO:0048298,positive regulation of isotype switching to IgA isotypes;GO:0048304,positive regulation of isotype switching to IgG isotypes;GO:0006301,postreplication repair;GO:0071168,protein localization to chromatin;GO:0010224,response to UV-B;GO:0010165,response to X-ray;GO:0016446,somatic hypermutation of immunoglobulin genes;GO:0016447,somatic recombination of immunoglobulin gene segments;GO:0002204,somatic recombination of immunoglobulin genes involved in immune response	hsa:4436,path:hsa03430,Mismatch repair;hsa:4436,path:hsa05200,Pathways in cancer;hsa:4436,path:hsa05210,Colorectal cancer;hsa:4436,path:hsa01524,Platinum drug resistance
TAP1_HUMAN	Q03518	TAP1	Antigen peptide transporter 1	2.537647806	1.137490855	3.328705686	2.142056045	1.8375693305	2.7353808655	1.8375693305	2.7353808655	0.671778235227258	0.380703	0	1.48858648220675	0.380922	0	GO:0034451,centriolar satellite;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0042824,MHC class I peptide loading complex;GO:0030670,phagocytic vesicle membrane;GO:0042825,TAP complex	GO:0015433,ABC-type peptide antigen transporter activity;GO:0015440,ABC-type peptide transporter activity;GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0042626,ATPase-coupled transmembrane transporter activity;GO:0046872,metal ion binding;GO:0042288,MHC class I protein binding;GO:0023029,MHC class Ib protein binding;GO:0042605,peptide antigen binding;GO:1904680,peptide transmembrane transporter activity;GO:0042803,protein homodimerization activity;GO:0046978,TAP1 binding;GO:0046979,TAP2 binding;GO:0042287,MHC protein binding	GO:0002250,adaptive immune response;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0046967,cytosol to endoplasmic reticulum transport;GO:0006952,defense response;GO:0015833,peptide transport;GO:0015031,protein transport;GO:0055085,transmembrane transport;GO:1990668,vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane;GO:0016032,viral process	hsa:6890,path:hsa02010,ABC transporters;hsa:6890,path:hsa04145,Phagosome;hsa:6890,path:hsa04612,Antigen processing and presentation;hsa:6890,path:hsa05340,Primary immunodeficiency;hsa:6890,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:6890,path:hsa05168,Herpes simplex virus 1 infection;hsa:6890,path:hsa05163,Human cytomegalovirus infection;hsa:6890,path:hsa05169,Epstein-Barr virus infection
CSK2B_HUMAN	P67870	CSNK2B	Casein kinase II subunit beta	0.291502282	0.569117136	0.215943839	0.199486547	0.430309709	0.207715193	0.430309709	0.207715193	2.07163329164853	0.217184	0	0.4827109141523	0.216635	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005956,protein kinase CK2 complex;GO:0034774,secretory granule lumen;GO:0000785,chromatin;GO:0005929,cilium;GO:0016363,nuclear matrix;GO:0005886,plasma membrane	GO:0003682,chromatin binding;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0019904,protein domain specific binding;GO:0019887,protein kinase regulator activity;GO:0004674,protein serine/threonine kinase activity;GO:0005102,signaling receptor binding;GO:0008134,transcription factor binding;GO:0016301,kinase activity;GO:0043021,ribonucleoprotein complex binding	GO:0033211,adiponectin-activated signaling pathway;GO:0034622,cellular protein-containing complex assembly;GO:0061154,endothelial tube morphogenesis;GO:0016236,macroautophagy;GO:0007076,mitotic chromosome condensation;GO:0043537,negative regulation of blood vessel endothelial cell migration;GO:0008285,negative regulation of cell population proliferation;GO:0043312,neutrophil degranulation;GO:0018107,peptidyl-threonine phosphorylation;GO:0006656,phosphatidylcholine biosynthetic process;GO:0032927,positive regulation of activin receptor signaling pathway;GO:0010862,positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0006457,protein folding;GO:0051101,regulation of DNA binding;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0007165,signal transduction;GO:0016055,Wnt signaling pathway;GO:0097421,liver regeneration;GO:0033574,response to testosterone	hsa:1460,path:hsa03008,Ribosome biogenesis in eukaryotes;hsa:1460,path:hsa04310,Wnt signaling pathway;hsa:1460,path:hsa04064,NF-kappa B signaling pathway;hsa:1460,path:hsa04137,Mitophagy - animal;hsa:1460,path:hsa04520,Adherens junction;hsa:1460,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:1460,path:hsa05162,Measles
ESYT1_HUMAN	Q9BSJ8	ESYT1	Extended synaptotagmin-1	4.85282001	12.15666777	8.837086761	14.78553055	8.50474389	11.8113086555	8.50474389	11.8113086555	0.720050939151414	0.421684	0	1.38879063358838	0.421862	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0031227,intrinsic component of endoplasmic reticulum membrane;GO:0016020,membrane	GO:0005509,calcium ion binding;GO:0005544,calcium-dependent phospholipid binding;GO:0042802,identical protein binding;GO:0031210,phosphatidylcholine binding;GO:0008429,phosphatidylethanolamine binding;GO:0035091,phosphatidylinositol binding;GO:0008289,lipid binding	GO:0061817,endoplasmic reticulum-plasma membrane tethering;GO:0006687,glycosphingolipid metabolic process;GO:0006869,lipid transport	
CDK1_HUMAN	P06493	CDK1	Cyclin-dependent kinase 1	0.293275057	0.21531864	0.272263712	0.566349497	0.2542968485	0.4193066045	0.2542968485	0.4193066045	0.606469933387372	0.322783	0	1.64888635849532	0.323054	0	GO:0005813,centrosome;GO:0000781,chromosome, telomeric region;GO:0097125,cyclin B1-CDK1 complex;GO:0000307,cyclin-dependent protein kinase holoenzyme complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0030496,midbody;GO:0005739,mitochondrion;GO:0072686,mitotic spindle;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005876,spindle microtubule;GO:0005759,mitochondrial matrix	GO:0005524,ATP binding;GO:0030332,cyclin binding;GO:0097472,cyclin-dependent protein kinase activity;GO:0004693,cyclin-dependent protein serine/threonine kinase activity;GO:0035173,histone kinase activity;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0008353,RNA polymerase II CTD heptapeptide repeat kinase activity;GO:0001618,virus receptor activity;GO:0003682,chromatin binding;GO:0030544,Hsp70 protein binding	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0006915,apoptotic process;GO:0051301,cell division;GO:0016477,cell migration;GO:0007098,centrosome cycle;GO:0097711,ciliary basal body-plasma membrane docking;GO:0006977,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0006281,DNA repair;GO:0006260,DNA replication;GO:0030855,epithelial cell differentiation;GO:0070371,ERK1 and ERK2 cascade;GO:0000086,G2/M transition of mitotic cell cycle;GO:0090166,Golgi disassembly;GO:0000226,microtubule cytoskeleton organization;GO:0007076,mitotic chromosome condensation;GO:0007095,mitotic G2 DNA damage checkpoint;GO:0007077,mitotic nuclear envelope disassembly;GO:0007084,mitotic nuclear envelope reassembly;GO:0043066,negative regulation of apoptotic process;GO:0018105,peptidyl-serine phosphorylation;GO:0018107,peptidyl-threonine phosphorylation;GO:0010971,positive regulation of G2/M transition of mitotic cell cycle;GO:1905448,positive regulation of mitochondrial ATP synthesis coupled electron transport;GO:1900182,positive regulation of protein localization to nucleus;GO:0007344,pronuclear fusion;GO:0016579,protein deubiquitination;GO:0034501,protein localization to kinetochore;GO:0006468,protein phosphorylation;GO:0042752,regulation of circadian rhythm;GO:0045995,regulation of embryonic development;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0014038,regulation of Schwann cell differentiation;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0060260,regulation of transcription initiation from RNA polymerase II promoter;GO:0048511,rhythmic process;GO:0031100,animal organ regeneration;GO:0007569,cell aging;GO:0008283,cell population proliferation;GO:0070301,cellular response to hydrogen peroxide;GO:0030261,chromosome condensation;GO:0044772,mitotic cell cycle phase transition;GO:0010629,negative regulation of gene expression;GO:0060045,positive regulation of cardiac muscle cell proliferation;GO:0045740,positive regulation of DNA replication;GO:0010628,positive regulation of gene expression;GO:0045931,positive regulation of mitotic cell cycle;GO:0042307,positive regulation of protein import into nucleus;GO:0065003,protein-containing complex assembly;GO:0014823,response to activity;GO:0014075,response to amine;GO:0048678,response to axon injury;GO:0046686,response to cadmium ion;GO:0046688,response to copper ion;GO:0042493,response to drug;GO:0045471,response to ethanol;GO:0014070,response to organic cyclic compound;GO:0009636,response to toxic substance;GO:0055015,ventricular cardiac muscle cell development	hsa:983,path:hsa04110,Cell cycle;hsa:983,path:hsa04114,Oocyte meiosis;hsa:983,path:hsa04115,p53 signaling pathway;hsa:983,path:hsa04218,Cellular senescence;hsa:983,path:hsa04540,Gap junction;hsa:983,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:983,path:hsa05203,Viral carcinogenesis;hsa:983,path:hsa05170,Human immunodeficiency virus 1 infection
STX12_HUMAN	Q86Y82	STX12	Syntaxin-12	0.608479817	0.563643285	0.807949863	1.03155772	0.586061551	0.9197537915	0.586061551	0.9197537915	0.637193949528829	0.350338	0	1.56938087805047	0.350586	0	GO:0031901,early endosome membrane;GO:0012505,endomembrane system;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0030285,integral component of synaptic vesicle membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0045121,membrane raft;GO:0005654,nucleoplasm;GO:0045335,phagocytic vesicle;GO:0000407,phagophore assembly site;GO:0098837,postsynaptic recycling endosome;GO:0055038,recycling endosome membrane;GO:0031201,SNARE complex;GO:0008021,synaptic vesicle;GO:0031982,vesicle;GO:0016020,membrane	GO:0005484,SNAP receptor activity;GO:0000149,SNARE binding	GO:0000045,autophagosome assembly;GO:0033344,cholesterol efflux;GO:0006886,intracellular protein transport;GO:0050821,protein stabilization;GO:0048278,vesicle docking;GO:0006906,vesicle fusion;GO:0016192,vesicle-mediated transport	hsa:23673,path:hsa04145,Phagosome
HPT_HUMAN	P00738	HP	Haptoglobin	30.13420033	57.91291778	57.41039236	172.1810044	44.023559055	114.79569838	44.023559055	114.79569838	0.38349484933897	0.122952	0	2.60759695136375	0.123270	0	GO:0072562,blood microparticle;GO:0071682,endocytic vesicle lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0031838,haptoglobin-hemoglobin complex;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen	GO:0016209,antioxidant activity;GO:0030492,hemoglobin binding;GO:0004252,serine-type endopeptidase activity	GO:0002526,acute inflammatory response;GO:0006953,acute-phase response;GO:0006952,defense response;GO:0042742,defense response to bacterium;GO:2000296,negative regulation of hydrogen peroxide catabolic process;GO:0051354,negative regulation of oxidoreductase activity;GO:0043312,neutrophil degranulation;GO:0010942,positive regulation of cell death;GO:0006898,receptor-mediated endocytosis;GO:0042542,response to hydrogen peroxide;GO:0031638,zymogen activation	
TMED4_HUMAN	Q7Z7H5	TMED4	Transmembrane emp24 domain-containing protein 4	0.720451523	3.628821144	0.476267645	0.163534251	2.1746363335	0.319900948	2.1746363335	0.319900948	6.79784272943136	0.037270	1	0.14710549211009	0.036937	-1	GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane		GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030,Golgi organization;GO:0006886,intracellular protein transport;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling	
SNX18_HUMAN	Q96RF0	SNX18	Sorting nexin-18	0.149042916	0.136378988	0.140308854	0.21713205	0.142710952	0.178720452	0.142710952	0.178720452	0.79851494556426	0.484238	0	1.25232471296246	0.484346	0	GO:0031410,cytoplasmic vesicle;GO:0030659,cytoplasmic vesicle membrane;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane	GO:0005546,phosphatidylinositol-4,5-bisphosphate binding	GO:0036089,cleavage furrow formation;GO:0006897,endocytosis;GO:0016197,endosomal transport;GO:0000281,mitotic cytokinesis;GO:0043547,positive regulation of GTPase activity;GO:0015031,protein transport	hsa:112574,path:hsa05132,Salmonella infection
EIF1_HUMAN	P41567	EIF1	Eukaryotic translation initiation factor 1	0.09667643	0.044494317	0.104478189	2.55E-05	0.0705853735	0.0522518445	0.0705853735	0.0522518445	1.35086855163553	0.336754	0	0.740264475614059	0.336365	0	GO:0005737,cytoplasm;GO:0016282,eukaryotic 43S preinitiation complex;GO:0005634,nucleus	GO:0043024,ribosomal small subunit binding;GO:0003723,RNA binding;GO:0008135,translation factor activity, RNA binding;GO:0003743,translation initiation factor activity	GO:0006446,regulation of translational initiation;GO:0009048,dosage compensation by inactivation of X chromosome	hsa:10209,path:hsa03013,RNA transport
RBMX_HUMAN	P38159	RBMX	RNA-binding motif protein, X chromosome	4.387188852	4.533883713	3.241661318	1.561770374	4.4605362825	2.401715846	4.4605362825	2.401715846	1.85722898482304	0.245206	0	0.538436567688652	0.244683	0	GO:0071013,catalytic step 2 spliceosome;GO:0000791,euchromatin;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:1990904,ribonucleoprotein complex;GO:0005681,spliceosomal complex;GO:0044530,supraspliceosomal complex	GO:0003682,chromatin binding;GO:0042802,identical protein binding;GO:0003729,mRNA binding;GO:0019904,protein domain specific binding;GO:0003723,RNA binding;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003727,single-stranded RNA binding;GO:0003676,nucleic acid binding	GO:0071347,cellular response to interleukin-1;GO:0006509,membrane protein ectodomain proteolysis;GO:0006376,mRNA splice site selection;GO:0000398,mRNA splicing, via spliceosome;GO:0048025,negative regulation of mRNA splicing, via spliceosome;GO:0001649,osteoblast differentiation;GO:0048026,positive regulation of mRNA splicing, via spliceosome;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0051260,protein homooligomerization;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0016070,RNA metabolic process;GO:0006366,transcription by RNA polymerase II	hsa:27316,path:hsa03040,Spliceosome
MYH10_HUMAN	P35580	MYH10	Myosin-10	12.57280915	11.2258985	12.34519201	55.3041609	11.899353825	33.824676455	11.899353825	33.824676455	0.351795052373399	0.098143	0	2.84256413856153	0.098439	0	GO:0042641,actomyosin;GO:0005938,cell cortex;GO:0032154,cleavage furrow;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0030027,lamellipodium;GO:0030496,midbody;GO:0016459,myosin complex;GO:0016460,myosin II complex;GO:0097513,myosin II filament;GO:0005634,nucleus;GO:0005844,polysome;GO:0001725,stress fiber	GO:0003779,actin binding;GO:0051015,actin filament binding;GO:0030898,actin-dependent ATPase activity;GO:0043531,ADP binding;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0005516,calmodulin binding;GO:0000146,microfilament motor activity;GO:0048027,mRNA 5'-UTR binding;GO:0035613,RNA stem-loop binding;GO:0003774,motor activity	GO:0030048,actin filament-based movement;GO:0031032,actomyosin structure organization;GO:0007155,cell adhesion;GO:0000281,mitotic cytokinesis;GO:0098885,modification of postsynaptic actin cytoskeleton;GO:0050714,positive regulation of protein secretion;GO:0008360,regulation of cell shape	hsa:4628,path:hsa04530,Tight junction;hsa:4628,path:hsa04810,Regulation of actin cytoskeleton;hsa:4628,path:hsa05130,Pathogenic Escherichia coli infection;hsa:4628,path:hsa05132,Salmonella infection
RO52_HUMAN	P19474	TRIM21	E3 ubiquitin-protein ligase TRIM21	0.125773181	0.60033282	2.081022883	3.837234158	0.3630530005	2.9591285205	0.3630530005	2.9591285205	0.12268916269938	0.001854	-1	8.1506791471897	0.001875	1	GO:0005776,autophagosome;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body;GO:1990904,ribonucleoprotein complex	GO:0003677,DNA binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:0019901,protein kinase binding;GO:0003723,RNA binding;GO:0003713,transcription coactivator activity;GO:0061630,ubiquitin protein ligase activity;GO:0004842,ubiquitin-protein transferase activity;GO:0008270,zinc ion binding	GO:0007049,cell cycle;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0045824,negative regulation of innate immune response;GO:0032088,negative regulation of NF-kappaB transcription factor activity;GO:0090086,negative regulation of protein deubiquitination;GO:1902187,negative regulation of viral release from host cell;GO:0032897,negative regulation of viral transcription;GO:0010508,positive regulation of autophagy;GO:0045787,positive regulation of cell cycle;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0032092,positive regulation of protein binding;GO:0046598,positive regulation of viral entry into host cell;GO:0051865,protein autoubiquitination;GO:0031648,protein destabilization;GO:0070534,protein K63-linked ubiquitination;GO:0006513,protein monoubiquitination;GO:0000209,protein polyubiquitination;GO:0016567,protein ubiquitination;GO:0010468,regulation of gene expression;GO:0032880,regulation of protein localization;GO:0032479,regulation of type I interferon production;GO:0046596,regulation of viral entry into host cell;GO:0034341,response to interferon-gamma	hsa:6737,path:hsa05322,Systemic lupus erythematosus
LYN_HUMAN	P07948	LYN	Tyrosine-protein kinase Lyn	0.169295456	0.136539964	0.433276217	0.299944207	0.15291771	0.366610212	0.15291771	0.366610212	0.417112521677383	0.151050	0	2.3974346202281	0.151381	0	GO:0005912,adherens junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0098978,glutamatergic synapse;GO:0005794,Golgi apparatus;GO:0034666,integrin alpha2-beta1 complex;GO:0043231,intracellular membrane-bounded organelle;GO:0045121,membrane raft;GO:0030061,mitochondrial crista;GO:0005758,mitochondrial intermembrane space;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0099091,postsynaptic specialization, intracellular component	GO:0005524,ATP binding;GO:0019899,enzyme binding;GO:0046875,ephrin receptor binding;GO:0043015,gamma-tubulin binding;GO:0043208,glycosphingolipid binding;GO:0005178,integrin binding;GO:0044325,ion channel binding;GO:0016301,kinase activity;GO:0004715,non-membrane spanning protein tyrosine kinase activity;GO:0051219,phosphoprotein binding;GO:0140031,phosphorylation-dependent protein binding;GO:0005161,platelet-derived growth factor receptor binding;GO:0004713,protein tyrosine kinase activity;GO:0017124,SH3 domain binding;GO:0005102,signaling receptor binding;GO:0004714,transmembrane receptor protein tyrosine kinase activity;GO:0031625,ubiquitin protein ligase binding	GO:0002250,adaptive immune response;GO:0001782,B cell homeostasis;GO:0050853,B cell receptor signaling pathway;GO:0007596,blood coagulation;GO:0030154,cell differentiation;GO:0006974,cellular response to DNA damage stimulus;GO:0031668,cellular response to extracellular stimulus;GO:0034605,cellular response to heat;GO:0071300,cellular response to retinoic acid;GO:0097028,dendritic cell differentiation;GO:0048013,ephrin receptor signaling pathway;GO:0030218,erythrocyte differentiation;GO:0002774,Fc receptor mediated inhibitory signaling pathway;GO:0002431,Fc receptor mediated stimulatory signaling pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0060397,growth hormone receptor signaling pathway via JAK-STAT;GO:0002553,histamine secretion by mast cell;GO:0002768,immune response-regulating cell surface receptor signaling pathway;GO:0045087,innate immune response;GO:0035556,intracellular signal transduction;GO:0050900,leukocyte migration;GO:0031663,lipopolysaccharide-mediated signaling pathway;GO:0030889,negative regulation of B cell proliferation;GO:0008285,negative regulation of cell population proliferation;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:0050777,negative regulation of immune response;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:1902532,negative regulation of intracellular signal transduction;GO:0043407,negative regulation of MAP kinase activity;GO:0070667,negative regulation of mast cell proliferation;GO:0002762,negative regulation of myeloid leukocyte differentiation;GO:0001933,negative regulation of protein phosphorylation;GO:0034136,negative regulation of toll-like receptor 2 signaling pathway;GO:0034144,negative regulation of toll-like receptor 4 signaling pathway;GO:0031175,neuron projection development;GO:0014003,oligodendrocyte development;GO:0018108,peptidyl-tyrosine phosphorylation;GO:0030168,platelet activation;GO:0002576,platelet degranulation;GO:1902961,positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0051272,positive regulation of cellular component movement;GO:2000670,positive regulation of dendritic cell apoptotic process;GO:0060369,positive regulation of Fc receptor mediated stimulatory signaling pathway;GO:0060252,positive regulation of glial cell proliferation;GO:0070668,positive regulation of mast cell proliferation;GO:0010976,positive regulation of neuron projection development;GO:0070447,positive regulation of oligodendrocyte progenitor proliferation;GO:0043552,positive regulation of phosphatidylinositol 3-kinase activity;GO:0014068,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0001934,positive regulation of protein phosphorylation;GO:0046579,positive regulation of Ras protein signal transduction;GO:0070304,positive regulation of stress-activated protein kinase signaling cascade;GO:0042531,positive regulation of tyrosine phosphorylation of STAT protein;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:0002902,regulation of B cell apoptotic process;GO:0050855,regulation of B cell receptor signaling pathway;GO:0033628,regulation of cell adhesion mediated by integrin;GO:0001817,regulation of cytokine production;GO:0070372,regulation of ERK1 and ERK2 cascade;GO:0045646,regulation of erythrocyte differentiation;GO:0033003,regulation of mast cell activation;GO:0043304,regulation of mast cell degranulation;GO:0090025,regulation of monocyte chemotaxis;GO:0090330,regulation of platelet aggregation;GO:0001932,regulation of protein phosphorylation;GO:0051279,regulation of release of sequestered calcium ion into cytosol;GO:0043200,response to amino acid;GO:0048678,response to axon injury;GO:0009743,response to carbohydrate;GO:0042493,response to drug;GO:0009725,response to hormone;GO:0032868,response to insulin;GO:0014070,response to organic cyclic compound;GO:0006991,response to sterol depletion;GO:0009636,response to toxic substance;GO:0007165,signal transduction;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0031295,T cell costimulation;GO:0002513,tolerance induction to self antigen;GO:0034142,toll-like receptor 4 signaling pathway;GO:0007169,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0016032,viral process	hsa:4067,path:hsa04064,NF-kappa B signaling pathway;hsa:4067,path:hsa04611,Platelet activation;hsa:4067,path:hsa04662,B cell receptor signaling pathway;hsa:4067,path:hsa04664,Fc epsilon RI signaling pathway;hsa:4067,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:4067,path:hsa04062,Chemokine signaling pathway;hsa:4067,path:hsa04730,Long-term depression;hsa:4067,path:hsa05203,Viral carcinogenesis;hsa:4067,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:4067,path:hsa05130,Pathogenic Escherichia coli infection;hsa:4067,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:4067,path:hsa05169,Epstein-Barr virus infection
ARF4_HUMAN	P18085	ARF4	ADP-ribosylation factor 4	27.30264794	115.2937926	5.081429856	2.095090604	71.29822027	3.58826023	71.29822027	3.58826023	19.869857730469	0.003601	1	0.0503274866667299	0.003536	-1	GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0005794,Golgi apparatus;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0032587,ruffle membrane;GO:0016021,integral component of membrane	GO:0005154,epidermal growth factor receptor binding;GO:0005525,GTP binding	GO:0031584,activation of phospholipase D activity;GO:0045176,apical protein localization;GO:0007420,brain development;GO:0016477,cell migration;GO:0060271,cilium assembly;GO:0060996,dendritic spine development;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007173,epidermal growth factor receptor signaling pathway;GO:0045197,establishment or maintenance of epithelial cell apical/basal polarity;GO:0006886,intracellular protein transport;GO:0007612,learning;GO:0043066,negative regulation of apoptotic process;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0006471,protein ADP-ribosylation;GO:0061512,protein localization to cilium;GO:0099175,regulation of postsynapse organization;GO:2000377,regulation of reactive oxygen species metabolic process;GO:0048678,response to axon injury;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0016192,vesicle-mediated transport	
GLYM_HUMAN	P34897	SHMT2	Serine hydroxymethyltransferase, mitochondrial	9.085291863	4.603345492	6.188490714	2.922644731	6.8443186775	4.5555677225	6.8443186775	4.5555677225	1.50240740439349	0.304692	0	0.66559842362045	0.304249	0	GO:0070552,BRISC complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0015630,microtubule cytoskeleton;GO:0005743,mitochondrial inner membrane;GO:0005758,mitochondrial intermembrane space;GO:0005759,mitochondrial matrix;GO:0042645,mitochondrial nucleoid;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0003682,chromatin binding;GO:0050897,cobalt ion binding;GO:0004372,glycine hydroxymethyltransferase activity;GO:0008732,L-allo-threonine aldolase activity;GO:0048027,mRNA 5'-UTR binding;GO:0042803,protein homodimerization activity;GO:0030170,pyridoxal phosphate binding;GO:0070905,serine binding;GO:0000900,translation repressor activity, mRNA regulatory element binding;GO:0008270,zinc ion binding	GO:0046655,folic acid metabolic process;GO:0019264,glycine biosynthetic process from serine;GO:0006544,glycine metabolic process;GO:0006564,L-serine biosynthetic process;GO:0006565,L-serine catabolic process;GO:0006563,L-serine metabolic process;GO:0006730,one-carbon metabolic process;GO:0008284,positive regulation of cell population proliferation;GO:0051289,protein homotetramerization;GO:0070536,protein K63-linked deubiquitination;GO:0051262,protein tetramerization;GO:0009113,purine nucleobase biosynthetic process;GO:1903715,regulation of aerobic respiration;GO:0070129,regulation of mitochondrial translation;GO:0002082,regulation of oxidative phosphorylation;GO:0034340,response to type I interferon;GO:0035999,tetrahydrofolate interconversion;GO:0046653,tetrahydrofolate metabolic process	hsa:6472,path:hsa00630,Glyoxylate and dicarboxylate metabolism;hsa:6472,path:hsa00260,Glycine, serine and threonine metabolism;hsa:6472,path:hsa00670,One carbon pool by folate;hsa:6472,path:hsa01523,Antifolate resistance
LMCD1_HUMAN	Q9NZU5	LMCD1	LIM and cysteine-rich domains protein 1	1.92987546	1.680767413	1.249944961	4.127786876	1.8053214365	2.6888659185	1.8053214365	2.6888659185	0.671406269862318	0.380381	0	1.48941117306674	0.380600	0	GO:0005737,cytoplasm;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003714,transcription corepressor activity;GO:0008270,zinc ion binding	GO:0044267,cellular protein metabolic process;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0070886,positive regulation of calcineurin-NFAT signaling cascade;GO:0010611,regulation of cardiac muscle hypertrophy	
TLN1_HUMAN	Q9Y490	TLN1	Talin-1	41.9823178	39.06612349	59.44984008	120.2231626	40.524220645	89.83650134	40.524220645	89.83650134	0.45108858916522	0.180813	0	2.21685944627992	0.181149	0	GO:0005912,adherens junction;GO:0009986,cell surface;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005925,focal adhesion;GO:0005886,plasma membrane;GO:0001726,ruffle;GO:0032587,ruffle membrane	GO:0051015,actin filament binding;GO:0045296,cadherin binding;GO:0005178,integrin binding;GO:0030274,LIM domain binding;GO:0035091,phosphatidylinositol binding;GO:0001786,phosphatidylserine binding;GO:0005200,structural constituent of cytoskeleton;GO:0017166,vinculin binding	GO:0098609,cell-cell adhesion;GO:0007043,cell-cell junction assembly;GO:0007044,cell-substrate junction assembly;GO:0030866,cortical actin cytoskeleton organization;GO:0033622,integrin activation;GO:0007229,integrin-mediated signaling pathway;GO:0036498,IRE1-mediated unfolded protein response;GO:0006936,muscle contraction;GO:0070527,platelet aggregation;GO:0002576,platelet degranulation;GO:0016032,viral process	hsa:7094,path:hsa04015,Rap1 signaling pathway;hsa:7094,path:hsa04510,Focal adhesion;hsa:7094,path:hsa04611,Platelet activation;hsa:7094,path:hsa05131,Shigellosis;hsa:7094,path:hsa05166,Human T-cell leukemia virus 1 infection
COIA1_HUMAN	P39060	COL18A1	Collagen alpha-1(XVIII) chain	1.283245908	4.62688131	3.012057757	10.08559032	2.955063609	6.5488240385	2.955063609	6.5488240385	0.451235762577743	0.180945	0	2.21613640347868	0.181280	0	GO:0005604,basement membrane;GO:0005581,collagen trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0005201,extracellular matrix structural constituent;GO:0042802,identical protein binding;GO:0046872,metal ion binding	GO:0001525,angiogenesis;GO:0009887,animal organ morphogenesis;GO:0007155,cell adhesion;GO:0030199,collagen fibril organization;GO:0001886,endothelial cell morphogenesis;GO:0030198,extracellular matrix organization;GO:0008285,negative regulation of cell population proliferation;GO:0042493,response to drug;GO:0051599,response to hydrostatic pressure;GO:0007601,visual perception	hsa:80781,path:hsa04974,Protein digestion and absorption
PSMD1_HUMAN	Q99460	PSMD1	26S proteasome non-ATPase regulatory subunit 1	3.871093122	2.559885101	5.565042459	5.576825171	3.2154891115	5.570933815	3.2154891115	5.570933815	0.577190327201904	0.296134	0	1.73253076649394	0.296426	0	GO:0035578,azurophil granule lumen;GO:0005829,cytosol;GO:0005576,extracellular region;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0022624,proteasome accessory complex;GO:0000502,proteasome complex;GO:0005838,proteasome regulatory particle;GO:0008540,proteasome regulatory particle, base subcomplex;GO:0034515,proteasome storage granule	GO:0030234,enzyme regulator activity;GO:0031625,ubiquitin protein ligase binding	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0043312,neutrophil degranulation;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0042176,regulation of protein catabolic process;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5707,path:hsa03050,Proteasome;hsa:5707,path:hsa05169,Epstein-Barr virus infection
IMA1_HUMAN	P52292	KPNA2	Importin subunit alpha-1	0.298586067	0.017554073	0.34855567	2.55E-05	0.15807007	0.174290585	0.15807007	0.174290585	0.906934072199023	0.465927	0	1.10261597910344	0.465801	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0098892,extrinsic component of postsynaptic specialization membrane;GO:0098978,glutamatergic synapse;GO:0000139,Golgi membrane;GO:0043657,host cell;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0042826,histone deacetylase binding;GO:0061608,nuclear import signal receptor activity;GO:0008139,nuclear localization sequence binding;GO:0003723,RNA binding	GO:0006259,DNA metabolic process;GO:0006302,double-strand break repair;GO:0075506,entry of viral genome into host nucleus through nuclear pore complex via importin;GO:0019054,modulation by virus of host cellular process;GO:0006607,NLS-bearing protein import into nucleus;GO:1903902,positive regulation of viral life cycle;GO:0099527,postsynapse to nucleus signaling pathway;GO:0000018,regulation of DNA recombination;GO:0006606,protein import into nucleus	hsa:3838,path:hsa05164,Influenza A
AP2M1_HUMAN	Q96CW1	AP2M1	AP-2 complex subunit mu	3.072849896	2.081794499	2.091939492	5.88227676	2.5773221975	3.987108126	2.5773221975	3.987108126	0.646413921080604	0.358507	0	1.54699638635305	0.358747	0	GO:0030122,AP-2 adaptor complex;GO:0045334,clathrin-coated endocytic vesicle;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0005905,clathrin-coated pit;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0030666,endocytic vesicle membrane;GO:0036020,endolysosome membrane;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0005765,lysosomal membrane;GO:0005886,plasma membrane;GO:0030131,clathrin adaptor complex;GO:0098978,glutamatergic synapse;GO:0098794,postsynapse;GO:0098793,presynapse	GO:0035615,clathrin adaptor activity;GO:0044325,ion channel binding;GO:0008289,lipid binding;GO:0050750,low-density lipoprotein particle receptor binding;GO:0005048,signal sequence binding;GO:0097718,disordered domain specific binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0034622,cellular protein-containing complex assembly;GO:0072583,clathrin-dependent endocytosis;GO:0006897,endocytosis;GO:0048013,ephrin receptor signaling pathway;GO:0006886,intracellular protein transport;GO:0034383,low-density lipoprotein particle clearance;GO:0032802,low-density lipoprotein particle receptor catabolic process;GO:0061024,membrane organization;GO:1903077,negative regulation of protein localization to plasma membrane;GO:0031623,receptor internalization;GO:0050690,regulation of defense response to virus by virus;GO:0097494,regulation of vesicle size;GO:0006900,vesicle budding from membrane;GO:0016192,vesicle-mediated transport;GO:0060071,Wnt signaling pathway, planar cell polarity pathway;GO:0002092,positive regulation of receptor internalization;GO:1900244,positive regulation of synaptic vesicle endocytosis;GO:0098884,postsynaptic neurotransmitter receptor internalization;GO:0065003,protein-containing complex assembly;GO:0048488,synaptic vesicle endocytosis	hsa:1173,path:hsa04144,Endocytosis;hsa:1173,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:1173,path:hsa04721,Synaptic vesicle cycle;hsa:1173,path:hsa05016,Huntington disease
AGAL_HUMAN	P06280	GLA	Alpha-galactosidase A	0.146370839	0.162965527	0.233102849	2.55E-05	0.154668183	0.1165641745	0.154668183	0.1165641745	1.32689296401271	0.342282	0	0.753640291358437	0.341902	0	GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005794,Golgi apparatus;GO:0043202,lysosomal lumen;GO:0005764,lysosome	GO:0004557,alpha-galactosidase activity;GO:0003824,catalytic activity;GO:0017041,galactosylgalactosylglucosylceramidase activity;GO:0016787,hydrolase activity;GO:0042803,protein homodimerization activity;GO:0052692,raffinose alpha-galactosidase activity;GO:0005102,signaling receptor binding;GO:0004553,hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0016936,galactoside binding	GO:0016139,glycoside catabolic process;GO:0046479,glycosphingolipid catabolic process;GO:0006687,glycosphingolipid metabolic process;GO:0046477,glycosylceramide catabolic process;GO:0045019,negative regulation of nitric oxide biosynthetic process;GO:0051001,negative regulation of nitric-oxide synthase activity;GO:0043312,neutrophil degranulation;GO:0009311,oligosaccharide metabolic process;GO:0005975,carbohydrate metabolic process	hsa:2717,path:hsa00052,Galactose metabolism;hsa:2717,path:hsa00561,Glycerolipid metabolism;hsa:2717,path:hsa00600,Sphingolipid metabolism;hsa:2717,path:hsa00603,Glycosphingolipid biosynthesis - globo and isoglobo series;hsa:2717,path:hsa04142,Lysosome
QOR_HUMAN	Q08257	CRYZ	Quinone oxidoreductase	2.764229734	5.694582347	5.656977797	4.736815012	4.2294060405	5.1968964045	4.2294060405	5.1968964045	0.813833047901003	0.495818	0	1.22875324684731	0.495914	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0042802,identical protein binding;GO:0003730,mRNA 3'-UTR binding;GO:0070402,NADPH binding;GO:0003960,NADPH;GO:0008270,zinc ion binding;GO:0016491,oxidoreductase activity	GO:0051289,protein homotetramerization;GO:0007601,visual perception;GO:0042178,xenobiotic catabolic process	
ARK72_HUMAN	O43488	AKR7A2	Aflatoxin B1 aldehyde reductase member 2	2.888513831	2.162852685	3.348849429	4.020822594	2.525683258	3.6848360115	2.525683258	3.6848360115	0.68542623067013	0.392466	0	1.45894620785422	0.392673	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus	GO:0004032,alditol;GO:0047834,D-threo-aldose 1-dehydrogenase activity;GO:0009055,electron transfer activity;GO:0019119,phenanthrene-9,10-epoxide hydrolase activity	GO:0046222,aflatoxin metabolic process;GO:0005975,carbohydrate metabolic process;GO:0006081,cellular aldehyde metabolic process;GO:0044597,daunorubicin metabolic process;GO:0044598,doxorubicin metabolic process	hsa:8574,path:hsa00980,Metabolism of xenobiotics by cytochrome P450
DCTD_HUMAN	P32321	DCTD	Deoxycytidylate deaminase	0.196653782	0.569258003	0.015254409	0.002306567	0.3829558925	0.008780488	0.3829558925	0.008780488	43.6144201210684	0.000404	1	0.022928196619928	0.000393	-1	GO:0005829,cytosol	GO:0004132,dCMP deaminase activity;GO:0042802,identical protein binding;GO:0008270,zinc ion binding;GO:0003824,catalytic activity	GO:0006231,dTMP biosynthetic process;GO:0006226,dUMP biosynthetic process;GO:0015949,nucleobase-containing small molecule interconversion;GO:0006220,pyrimidine nucleotide metabolic process	hsa:1635,path:hsa00240,Pyrimidine metabolism
NEDD4_HUMAN	P46934	NEDD4	E3 ubiquitin-protein ligase NEDD4	2.55E-05	0.028190241	2.55E-05	2.55E-05	0.0141078705	2.55e-005	0.0141078705	2.55e-005	553.249823529412	0.000000	1	0.00180750170622845	0.000000	-1	GO:0016327,apicolateral plasma membrane;GO:0005938,cell cortex;GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0000151,ubiquitin ligase complex	GO:0031698,beta-2 adrenergic receptor binding;GO:0019899,enzyme binding;GO:0050815,phosphoserine residue binding;GO:0050816,phosphothreonine residue binding;GO:0070064,proline-rich region binding;GO:0019904,protein domain specific binding;GO:0070063,RNA polymerase binding;GO:0019871,sodium channel inhibitor activity;GO:0043130,ubiquitin binding;GO:0061630,ubiquitin protein ligase activity;GO:0004842,ubiquitin-protein transferase activity	GO:0034644,cellular response to UV;GO:0044111,development involved in symbiotic interaction;GO:0042921,glucocorticoid receptor signaling pathway;GO:0007041,lysosomal transport;GO:2000650,negative regulation of sodium ion transmembrane transporter activity;GO:0010766,negative regulation of sodium ion transport;GO:0010768,negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage;GO:0030948,negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:0007528,neuromuscular junction development;GO:0031175,neuron projection development;GO:0046824,positive regulation of nucleocytoplasmic transport;GO:0014068,positive regulation of phosphatidylinositol 3-kinase signaling;GO:0045732,positive regulation of protein catabolic process;GO:0050847,progesterone receptor signaling pathway;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070534,protein K63-linked ubiquitination;GO:0000209,protein polyubiquitination;GO:0006622,protein targeting to lysosome;GO:0016567,protein ubiquitination;GO:0032801,receptor catabolic process;GO:0031623,receptor internalization;GO:0048814,regulation of dendrite morphogenesis;GO:0034765,regulation of ion transmembrane transport;GO:0016241,regulation of macroautophagy;GO:0042391,regulation of membrane potential;GO:1901016,regulation of potassium ion transmembrane transporter activity;GO:0050807,regulation of synapse organization;GO:0051592,response to calcium ion;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0043162,ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0046755,viral budding	hsa:4734,path:hsa04120,Ubiquitin mediated proteolysis;hsa:4734,path:hsa04144,Endocytosis;hsa:4734,path:hsa04530,Tight junction;hsa:4734,path:hsa05169,Epstein-Barr virus infection
STMN1_HUMAN	P16949	STMN1	Stathmin	1.603867238	1.111399849	0.555767509	0.035180465	1.3576335435	0.295473987	1.3576335435	0.295473987	4.59476503256444	0.073092	0	0.2176389854351	0.072625	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005874,microtubule;GO:0043005,neuron projection	GO:0015631,tubulin binding	GO:0007409,axonogenesis;GO:0007420,brain development;GO:0061436,establishment of skin barrier;GO:0048012,hepatocyte growth factor receptor signaling pathway;GO:0035556,intracellular signal transduction;GO:0007019,microtubule depolymerization;GO:0000281,mitotic cytokinesis;GO:0007052,mitotic spindle organization;GO:1905098,negative regulation of guanyl-nucleotide exchange factor activity;GO:0031115,negative regulation of microtubule polymerization;GO:0035024,negative regulation of Rho protein signal transduction;GO:0051497,negative regulation of stress fiber assembly;GO:0070495,negative regulation of thrombin-activated receptor signaling pathway;GO:0031175,neuron projection development;GO:0051272,positive regulation of cellular component movement;GO:0031110,regulation of microtubule polymerization or depolymerization;GO:0009615,response to virus;GO:0007165,signal transduction	hsa:3925,path:hsa04010,MAPK signaling pathway;hsa:3925,path:hsa05206,MicroRNAs in cancer
RUXE_HUMAN	P62304	SNRPE	Small nuclear ribonucleoprotein E	1.091336764	0.16113106	0.828086958	0.485314409	0.626233912	0.6567006835	0.626233912	0.6567006835	0.953606304568434	0.449150	0	1.04865078513985	0.448987	0	GO:0071013,catalytic step 2 spliceosome;GO:0005829,cytosol;GO:0034709,methylosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0034715,pICln-Sm protein complex;GO:0071011,precatalytic spliceosome;GO:0030532,small nuclear ribonucleoprotein complex;GO:0034719,SMN-Sm protein complex;GO:0005681,spliceosomal complex;GO:0005697,telomerase holoenzyme complex;GO:0005685,U1 snRNP;GO:0005689,U12-type spliceosomal complex;GO:0005686,U2 snRNP;GO:0071007,U2-type catalytic step 2 spliceosome;GO:0071005,U2-type precatalytic spliceosome;GO:0005687,U4 snRNP;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005682,U5 snRNP;GO:0005683,U7 snRNP	GO:0003723,RNA binding	GO:0042633,hair cycle;GO:0008334,histone mRNA metabolic process;GO:0051170,import into nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0000245,spliceosomal complex assembly;GO:0000387,spliceosomal snRNP assembly;GO:0006369,termination of RNA polymerase II transcription	hsa:6635,path:hsa03040,Spliceosome
EVL_HUMAN	Q9UI08	EVL	Ena/VASP-like protein	0.299913727	0.477618861	0.414124352	0.014214515	0.388766294	0.2141694335	0.388766294	0.2141694335	1.81522772716304	0.251310	0	0.550895066793007	0.250793	0	GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0016020,membrane	GO:0003779,actin binding;GO:0005522,profilin binding;GO:0017124,SH3 domain binding	GO:0007015,actin filament organization;GO:0045010,actin nucleation;GO:0008154,actin polymerization or depolymerization;GO:0009887,animal organ morphogenesis;GO:0007411,axon guidance;GO:0007166,cell surface receptor signaling pathway;GO:0010633,negative regulation of epithelial cell migration;GO:1900028,negative regulation of ruffle assembly;GO:0007399,nervous system development;GO:0030838,positive regulation of actin filament polymerization;GO:0051496,positive regulation of stress fiber assembly;GO:0051289,protein homotetramerization	hsa:51466,path:hsa04015,Rap1 signaling pathway
MCM5_HUMAN	P33992	MCM5	DNA replication licensing factor MCM5	3.703913878	7.230701344	6.211101229	6.93291721	5.467307611	6.5720092195	5.467307611	6.5720092195	0.831908086004778	0.494920	0	1.20205587230493	0.494859	0	GO:0000781,chromosome, telomeric region;GO:0071162,CMG complex;GO:0005829,cytosol;GO:0042555,MCM complex;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005694,chromosome	GO:0005524,ATP binding;GO:0003678,DNA helicase activity;GO:0003688,DNA replication origin binding;GO:0016787,hydrolase activity;GO:0003697,single-stranded DNA binding;GO:0003677,DNA binding	GO:0006260,DNA replication;GO:0006270,DNA replication initiation;GO:0000727,double-strand break repair via break-induced replication;GO:0036388,pre-replicative complex assembly;GO:0006267,pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0007049,cell cycle;GO:0051301,cell division	hsa:4174,path:hsa03030,DNA replication;hsa:4174,path:hsa04110,Cell cycle
ELOB_HUMAN	Q15370	ELOB	Elongin-B	2.036024033	6.246520691	0.214551077	0.049261859	4.141272362	0.131906468	4.141272362	0.131906468	31.3955215751816	0.001060	1	0.0318516766031531	0.001035	-1	GO:0031462,Cul2-RING ubiquitin ligase complex;GO:0031466,Cul5-RING ubiquitin ligase complex;GO:0005829,cytosol;GO:0070449,elongin complex;GO:0005654,nucleoplasm;GO:0030891,VCB complex	GO:0031625,ubiquitin protein ligase binding;GO:0003746,translation elongation factor activity	GO:0032436,positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0043687,post-translational protein modification;GO:0016567,protein ubiquitination;GO:0065003,protein-containing complex assembly;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter;GO:0016032,viral process	hsa:6923,path:hsa04120,Ubiquitin mediated proteolysis;hsa:6923,path:hsa04066,HIF-1 signaling pathway;hsa:6923,path:hsa05200,Pathways in cancer;hsa:6923,path:hsa05211,Renal cell carcinoma;hsa:6923,path:hsa05170,Human immunodeficiency virus 1 infection
BGAL_HUMAN	P16278	GLB1	Beta-galactosidase	3.019864011	2.367443606	3.605810236	6.732621264	2.6936538085	5.16921575	2.6936538085	5.16921575	0.521095256761144	0.244533	0	1.91903493080224	0.244854	0	GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0043202,lysosomal lumen;GO:0048471,perinuclear region of cytoplasm;GO:0005773,vacuole	GO:0004565,beta-galactosidase activity;GO:0016936,galactoside binding;GO:0042803,protein homodimerization activity;GO:0004553,hydrolase activity, hydrolyzing O-glycosyl compounds	GO:0044262,cellular carbohydrate metabolic process;GO:0019388,galactose catabolic process;GO:0006027,glycosaminoglycan catabolic process;GO:0006687,glycosphingolipid metabolic process;GO:0042340,keratan sulfate catabolic process;GO:0043312,neutrophil degranulation;GO:0051413,response to cortisone;GO:1904016,response to Thyroglobulin triiodothyronine;GO:0005975,carbohydrate metabolic process	hsa:2720,path:hsa00052,Galactose metabolism;hsa:2720,path:hsa00600,Sphingolipid metabolism;hsa:2720,path:hsa00531,Glycosaminoglycan degradation;hsa:2720,path:hsa00604,Glycosphingolipid biosynthesis - ganglio series;hsa:2720,path:hsa00511,Other glycan degradation;hsa:2720,path:hsa04142,Lysosome
TSP2_HUMAN	P35442	THBS2	Thrombospondin-2	8.907502027	3.71473352	2.063647623	2.32072258	6.3111177735	2.1921851015	6.3111177735	2.1921851015	2.87891646064998	0.144776	0	0.347352906438357	0.144210	0	GO:0062023,collagen-containing extracellular matrix;GO:0005576,extracellular region;GO:0031091,platelet alpha granule;GO:0005604,basement membrane	GO:0005509,calcium ion binding;GO:0008201,heparin binding	GO:0007155,cell adhesion;GO:0016525,negative regulation of angiogenesis;GO:0051965,positive regulation of synapse assembly	hsa:7058,path:hsa04151,PI3K-Akt signaling pathway;hsa:7058,path:hsa04512,ECM-receptor interaction;hsa:7058,path:hsa04145,Phagosome;hsa:7058,path:hsa04510,Focal adhesion;hsa:7058,path:hsa05165,Human papillomavirus infection;hsa:7058,path:hsa05144,Malaria
DOCK2_HUMAN	Q92608	DOCK2	Dedicator of cytokinesis protein 2	1.100883848	1.080682922	2.064130965	2.270254965	1.090783385	2.167192965	1.090783385	2.167192965	0.503316226388729	0.228182	0	1.98682249363378	0.228510	0	GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0016020,membrane;GO:0035580,specific granule lumen;GO:0005737,cytoplasm	GO:0005096,GTPase activator activity;GO:0005085,guanyl-nucleotide exchange factor activity;GO:0042608,T cell receptor binding	GO:0030036,actin cytoskeleton organization;GO:0046633,alpha-beta T cell proliferation;GO:0006935,chemotaxis;GO:0001768,establishment of T cell polarity;GO:0001771,immunological synapse formation;GO:0044351,macropinocytosis;GO:0001766,membrane raft polarization;GO:0002277,myeloid dendritic cell activation involved in immune response;GO:0045060,negative thymic T cell selection;GO:0043312,neutrophil degranulation;GO:0043547,positive regulation of GTPase activity;GO:0050766,positive regulation of phagocytosis;GO:0045059,positive thymic T cell selection;GO:0050690,regulation of defense response to virus by virus;GO:0007264,small GTPase mediated signal transduction	hsa:1794,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:1794,path:hsa04062,Chemokine signaling pathway
HS74L_HUMAN	O95757	HSPA4L	Heat shock 70 kDa protein 4L	1.239904742	0.360678259	0.609919603	0.890684332	0.8002915005	0.7503019675	0.8002915005	0.7503019675	1.06662588553055	0.412074	0	0.937535844165822	0.411832	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0016887,ATPase activity	GO:0006457,protein folding;GO:0006986,response to unfolded protein	hsa:22824,path:hsa04141,Protein processing in endoplasmic reticulum
ACADS_HUMAN	P16219	ACADS	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	0.555299669	1.30925794	2.388344765	1.339904762	0.9322788045	1.8641247635	0.9322788045	1.8641247635	0.500116098854668	0.225247	0	1.99953571238785	0.225575	0	GO:0005813,centrosome;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003995,acyl-CoA dehydrogenase activity;GO:0004085,butyryl-CoA dehydrogenase activity;GO:0050660,flavin adenine dinucleotide binding	GO:0046359,butyrate catabolic process;GO:0006635,fatty acid beta-oxidation;GO:0033539,fatty acid beta-oxidation using acyl-CoA dehydrogenase	hsa:35,path:hsa00640,Propanoate metabolism;hsa:35,path:hsa00650,Butanoate metabolism;hsa:35,path:hsa00071,Fatty acid degradation;hsa:35,path:hsa00280,Valine, leucine and isoleucine degradation;hsa:35,path:hsa00410,beta-Alanine metabolism
PKP3_HUMAN	Q9Y446	PKP3	Plakophilin-3	0.494419873	0.239953327	0.444055677	1.020699869	0.3671866	0.732377773	0.3671866	0.732377773	0.501362293527715	0.226390	0	1.99456563229704	0.226718	0	GO:0005912,adherens junction;GO:0030054,cell junction;GO:0005911,cell-cell junction;GO:0001533,cornified envelope;GO:0005737,cytoplasm;GO:0030057,desmosome;GO:1990124,messenger ribonucleoprotein complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0045294,alpha-catenin binding;GO:0045296,cadherin binding;GO:0098641,cadherin binding involved in cell-cell adhesion;GO:0050839,cell adhesion molecule binding;GO:0019899,enzyme binding	GO:0098609,cell-cell adhesion;GO:0007043,cell-cell junction assembly;GO:0070268,cornification;GO:0002159,desmosome assembly;GO:0031424,keratinization;GO:1902373,negative regulation of mRNA catabolic process;GO:0010628,positive regulation of gene expression;GO:0072659,protein localization to plasma membrane;GO:0006417,regulation of translation	
LSM6_HUMAN	P62312	LSM6	U6 snRNA-associated Sm-like protein LSm6	0.440366755	0.321513889	0.236751726	0.140696097	0.380940322	0.1887239115	0.380940322	0.1887239115	2.01850586378928	0.223675	0	0.495415949955542	0.223131	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0120115,Lsm2-8 complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000932,P-body;GO:0030532,small nuclear ribonucleoprotein complex;GO:0005732,sno(s)RNA-containing ribonucleoprotein complex;GO:0071005,U2-type precatalytic spliceosome;GO:0046540,U4/U6 x U5 tri-snRNP complex;GO:0005688,U6 snRNP	GO:0046982,protein heterodimerization activity;GO:0003723,RNA binding	GO:0043928,exonucleolytic catabolism of deadenylated mRNA;GO:0030490,maturation of SSU-rRNA;GO:0006402,mRNA catabolic process;GO:0000398,mRNA splicing, via spliceosome;GO:0008380,RNA splicing;GO:0008033,tRNA processing	hsa:11157,path:hsa03040,Spliceosome;hsa:11157,path:hsa03018,RNA degradation
DRS7B_HUMAN	Q6IAN0	DHRS7B	Dehydrogenase/reductase SDR family member 7B	0.151439031	0.074666094	0.233230667	0.102555785	0.1130525625	0.167893226	0.1130525625	0.167893226	0.673359879927496	0.382073	0	1.48508996423677	0.382291	0	GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005778,peroxisomal membrane	GO:0016491,oxidoreductase activity	GO:0008611,ether lipid biosynthetic process	
HV102_HUMAN	P23083	IGHV1-2	Immunoglobulin heavy variable 1-2	0.175179512	2.55E-05	0.323042524	0.094760512	0.087602506	0.208901518	0.087602506	0.208901518	0.419348345759747	0.152972	0	2.38465230663607	0.153304	0	GO:0009897,external side of plasma membrane;GO:0042571,immunoglobulin complex, circulating;GO:0005576,extracellular region;GO:0005886,plasma membrane;GO:0019814,immunoglobulin complex	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006956,complement activation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
DUS3_HUMAN	P51452	DUSP3	Dual specificity protein phosphatase 3	1.110049158	11.39127854	0.201103063	0.036795133	6.250663849	0.118949098	6.250663849	0.118949098	52.5490647184227	0.000227	1	0.0190298344101531	0.000220	-1	GO:0005829,cytosol;GO:0001772,immunological synapse;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0008092,cytoskeletal protein binding;GO:0033549,MAP kinase phosphatase activity;GO:0016791,phosphatase activity;GO:0019901,protein kinase binding;GO:0106306,protein serine phosphatase activity;GO:0106307,protein threonine phosphatase activity;GO:1990782,protein tyrosine kinase binding;GO:0004725,protein tyrosine phosphatase activity;GO:0008138,protein tyrosine/serine/threonine phosphatase activity;GO:0030971,receptor tyrosine kinase binding	GO:0071364,cellular response to epidermal growth factor stimulus;GO:0016311,dephosphorylation;GO:0000188,inactivation of MAPK activity;GO:0030336,negative regulation of cell migration;GO:0050922,negative regulation of chemotaxis;GO:0042059,negative regulation of epidermal growth factor receptor signaling pathway;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:0046329,negative regulation of JNK cascade;GO:0043409,negative regulation of MAPK cascade;GO:0050868,negative regulation of T cell activation;GO:0050860,negative regulation of T cell receptor signaling pathway;GO:0035335,peptidyl-tyrosine dephosphorylation;GO:1990264,peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;GO:0120183,positive regulation of focal adhesion disassembly;GO:0045931,positive regulation of mitotic cell cycle;GO:0051893,regulation of focal adhesion assembly	hsa:1845,path:hsa04010,MAPK signaling pathway
K1C10_HUMAN	P13645	KRT10	Keratin, type I cytoskeletal 10	349.7078768	163.3338553	174.301832	276.0940549	256.52086605	225.19794345	256.52086605	225.19794345	1.13909062454185	0.390654	0	0.877893275964948	0.390368	0	GO:0009986,cell surface;GO:0001533,cornified envelope;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005882,intermediate filament;GO:0016020,membrane;GO:0005634,nucleus	GO:0046982,protein heterodimerization activity;GO:0030280,structural constituent of skin epidermis	GO:0070268,cornification;GO:0031424,keratinization;GO:0030216,keratinocyte differentiation;GO:0018149,peptide cross-linking;GO:0045684,positive regulation of epidermis development;GO:0051290,protein heterotetramerization	hsa:3858,path:hsa04915,Estrogen signaling pathway;hsa:3858,path:hsa05150,Staphylococcus aureus infection
COASY_HUMAN	Q13057	COASY	Bifunctional coenzyme A synthase	0.83993236	0.701418855	1.317946909	1.083933345	0.7706756075	1.200940127	0.7706756075	1.200940127	0.641726918914085	0.354360	0	1.55829523513238	0.354605	0	GO:0070062,extracellular exosome;GO:0005759,mitochondrial matrix;GO:0005741,mitochondrial outer membrane	GO:0005524,ATP binding;GO:0004140,dephospho-CoA kinase activity;GO:0004595,pantetheine-phosphate adenylyltransferase activity	GO:0015937,coenzyme A biosynthetic process	hsa:80347,path:hsa00770,Pantothenate and CoA biosynthesis
SNX17_HUMAN	Q15036	SNX17	Sorting nexin-17	0.214726257	0.260366737	0.515107887	0.833417248	0.237546497	0.6742625675	0.237546497	0.6742625675	0.352305627584761	0.098527	0	2.83844458249368	0.098824	0	GO:0031410,cytoplasmic vesicle;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0005769,early endosome;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0032991,protein-containing complex	GO:0050750,low-density lipoprotein particle receptor binding;GO:0035091,phosphatidylinositol binding;GO:0008022,protein C-terminus binding;GO:0005102,signaling receptor binding	GO:0035904,aorta development;GO:0003279,cardiac septum development;GO:0006707,cholesterol catabolic process;GO:0060976,coronary vasculature development;GO:0032456,endocytic recycling;GO:0016197,endosomal transport;GO:0006886,intracellular protein transport;GO:0001822,kidney development;GO:0006898,receptor-mediated endocytosis;GO:0030100,regulation of endocytosis;GO:0007165,signal transduction	
VAS1_HUMAN	Q15904	ATP6AP1	V-type proton ATPase subunit S1	0.074398601	0.070255511	0.094169224	0.061409703	0.072327056	0.0777894635	0.072327056	0.0777894635	0.929779596693066	0.457600	0	1.07552370858286	0.457456	0	GO:0005789,endoplasmic reticulum membrane;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0033181,plasma membrane proton-transporting V-type ATPase complex;GO:0016469,proton-transporting two-sector ATPase complex;GO:0033180,proton-transporting V-type ATPase, V1 domain	GO:0005524,ATP binding;GO:0031267,small GTPase binding	GO:0006879,cellular iron ion homeostasis;GO:0036295,cellular response to increased oxygen levels;GO:0051656,establishment of organelle localization;GO:0008286,insulin receptor signaling pathway;GO:0034220,ion transmembrane transport;GO:0045851,pH reduction;GO:0045780,positive regulation of bone resorption;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0045921,positive regulation of exocytosis;GO:0045669,positive regulation of osteoblast differentiation;GO:2001206,positive regulation of osteoclast development;GO:1902600,proton transmembrane transport;GO:0030641,regulation of cellular pH;GO:0033572,transferrin transport	hsa:537,path:hsa00190,Oxidative phosphorylation;hsa:537,path:hsa04145,Phagosome;hsa:537,path:hsa04142,Lysosome;hsa:537,path:hsa05323,Rheumatoid arthritis;hsa:537,path:hsa05110,Vibrio cholerae infection;hsa:537,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:537,path:hsa05152,Tuberculosis;hsa:537,path:hsa05161,Hepatitis B;hsa:537,path:hsa05165,Human papillomavirus infection
INT3_HUMAN	Q68E01	INTS3	Integrator complex subunit 3	0.0672475	0.026347924	0.093881674	0.123342426	0.046797712	0.10861205	0.046797712	0.10861205	0.430870350021015	0.162964	0	2.32088376457379	0.163298	0	GO:0005737,cytoplasm;GO:0032039,integrator complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0035861,site of double-strand break;GO:0070876,SOSS complex		GO:0006974,cellular response to DNA damage stimulus;GO:0006281,DNA repair;GO:0044818,mitotic G2/M transition checkpoint;GO:0010212,response to ionizing radiation;GO:0016180,snRNA processing;GO:0042795,snRNA transcription by RNA polymerase II	
FAK2_HUMAN	Q14289	PTK2B	Protein-tyrosine kinase 2-beta	0.473595406	0.183924648	0.45630295	0.415473473	0.328760027	0.4358882115	0.328760027	0.4358882115	0.754230140495552	0.449583	0	1.32585526129063	0.449731	0	GO:0097440,apical dendrite;GO:0044297,cell body;GO:0005938,cell cortex;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0030425,dendrite;GO:0043197,dendritic spine;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0030426,growth cone;GO:0030027,lamellipodium;GO:0045121,membrane raft;GO:0043025,neuronal cell body;GO:0017146,NMDA selective glutamate receptor complex;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0014069,postsynaptic density	GO:0043423,3-phosphoinositide-dependent protein kinase binding;GO:0005524,ATP binding;GO:0004683,calmodulin-dependent protein kinase activity;GO:0004972,NMDA glutamate receptor activity;GO:0004715,non-membrane spanning protein tyrosine kinase activity;GO:0008022,protein C-terminus binding;GO:0004713,protein tyrosine kinase activity;GO:0044877,protein-containing complex binding;GO:0005102,signaling receptor binding;GO:0004714,transmembrane receptor protein tyrosine kinase activity;GO:0031625,ubiquitin protein ligase binding	GO:0090630,activation of GTPase activity;GO:0042976,activation of Janus kinase activity;GO:0002250,adaptive immune response;GO:0001525,angiogenesis;GO:0006915,apoptotic process;GO:0043534,blood vessel endothelial cell migration;GO:0045453,bone resorption;GO:0030154,cell differentiation;GO:0007166,cell surface receptor signaling pathway;GO:0006968,cellular defense response;GO:0071498,cellular response to fluid shear stress;GO:0071300,cellular response to retinoic acid;GO:0070098,chemokine-mediated signaling pathway;GO:0086100,endothelin receptor signaling pathway;GO:0007173,epidermal growth factor receptor signaling pathway;GO:0048041,focal adhesion assembly;GO:0014009,glial cell proliferation;GO:0045087,innate immune response;GO:0007229,integrin-mediated signaling pathway;GO:0038110,interleukin-2-mediated signaling pathway;GO:0035235,ionotropic glutamate receptor signaling pathway;GO:0060292,long-term synaptic depression;GO:0060291,long-term synaptic potentiation;GO:0000165,MAPK cascade;GO:0002315,marginal zone B cell differentiation;GO:0043066,negative regulation of apoptotic process;GO:0030502,negative regulation of bone mineralization;GO:0008285,negative regulation of cell population proliferation;GO:0010656,negative regulation of muscle cell apoptotic process;GO:0045638,negative regulation of myeloid cell differentiation;GO:0043524,negative regulation of neuron apoptotic process;GO:0043267,negative regulation of potassium ion transport;GO:0031175,neuron projection development;GO:0001556,oocyte maturation;GO:0038083,peptidyl-tyrosine autophosphorylation;GO:0018108,peptidyl-tyrosine phosphorylation;GO:0030838,positive regulation of actin filament polymerization;GO:0045766,positive regulation of angiogenesis;GO:2000538,positive regulation of B cell chemotaxis;GO:0030307,positive regulation of cell growth;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0001954,positive regulation of cell-matrix adhesion;GO:0007204,positive regulation of cytosolic calcium ion concentration;GO:2000573,positive regulation of DNA biosynthetic process;GO:0010595,positive regulation of endothelial cell migration;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:2000463,positive regulation of excitatory postsynaptic potential;GO:0046330,positive regulation of JNK cascade;GO:0043507,positive regulation of JUN kinase activity;GO:0010976,positive regulation of neuron projection development;GO:0045429,positive regulation of nitric oxide biosynthetic process;GO:0051000,positive regulation of nitric-oxide synthase activity;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0043552,positive regulation of phosphatidylinositol 3-kinase activity;GO:0045860,positive regulation of protein kinase activity;GO:2000379,positive regulation of reactive oxygen species metabolic process;GO:0051968,positive regulation of synaptic transmission, glutamatergic;GO:0045727,positive regulation of translation;GO:2000060,positive regulation of ubiquitin-dependent protein catabolic process;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:0065003,protein-containing complex assembly;GO:2000249,regulation of actin cytoskeleton reorganization;GO:0050848,regulation of calcium-mediated signaling;GO:0030155,regulation of cell adhesion;GO:0008360,regulation of cell shape;GO:0010752,regulation of cGMP-mediated signaling;GO:2000114,regulation of establishment of cell polarity;GO:0032960,regulation of inositol trisphosphate biosynthetic process;GO:0010758,regulation of macrophage chemotaxis;GO:2000310,regulation of NMDA receptor activity;GO:0051279,regulation of release of sequestered calcium ion into cytosol;GO:0048167,regulation of synaptic plasticity;GO:2000058,regulation of ubiquitin-dependent protein catabolic process;GO:0051592,response to calcium ion;GO:0051591,response to cAMP;GO:0042220,response to cocaine;GO:0042493,response to drug;GO:0045471,response to ethanol;GO:0009749,response to glucose;GO:0009725,response to hormone;GO:0042542,response to hydrogen peroxide;GO:0001666,response to hypoxia;GO:0035902,response to immobilization stress;GO:0010226,response to lithium ion;GO:0009612,response to mechanical stimulus;GO:0006970,response to osmotic stress;GO:0007172,signal complex assembly;GO:0007165,signal transduction;GO:0002040,sprouting angiogenesis;GO:0043149,stress fiber assembly;GO:0007169,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:0045765,regulation of angiogenesis;GO:0030500,regulation of bone mineralization;GO:0042127,regulation of cell population proliferation;GO:0002688,regulation of leukocyte chemotaxis	hsa:2185,path:hsa04020,Calcium signaling pathway;hsa:2185,path:hsa04072,Phospholipase D signaling pathway;hsa:2185,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:2185,path:hsa04670,Leukocyte transendothelial migration;hsa:2185,path:hsa04062,Chemokine signaling pathway;hsa:2185,path:hsa04912,GnRH signaling pathway;hsa:2185,path:hsa05135,Yersinia infection;hsa:2185,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:2185,path:hsa05161,Hepatitis B;hsa:2185,path:hsa05163,Human cytomegalovirus infection
G6PI_HUMAN	P06744	GPI	Glucose-6-phosphate isomerase	28.54627724	36.67509422	35.83668457	30.18022317	32.61068573	33.00845387	32.61068573	33.00845387	0.987949507069717	0.437374	0	1.01219747855943	0.437186	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0034774,secretory granule lumen;GO:0005615,extracellular space;GO:0060170,ciliary membrane;GO:0043005,neuron projection	GO:0005125,cytokine activity;GO:0004347,glucose-6-phosphate isomerase activity;GO:0008083,growth factor activity;GO:0048029,monosaccharide binding;GO:0031625,ubiquitin protein ligase binding	GO:0061621,canonical glycolysis;GO:0005975,carbohydrate metabolic process;GO:0006094,gluconeogenesis;GO:0051156,glucose 6-phosphate metabolic process;GO:0006096,glycolytic process;GO:0007599,hemostasis;GO:0006959,humoral immune response;GO:0043312,neutrophil degranulation;GO:0010595,positive regulation of endothelial cell migration;GO:0002639,positive regulation of immunoglobulin production;GO:0034101,erythrocyte homeostasis;GO:0042593,glucose homeostasis;GO:0001701,in utero embryonic development;GO:0007611,learning or memory;GO:0001707,mesoderm formation;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0043524,negative regulation of neuron apoptotic process;GO:0046686,response to cadmium ion;GO:0032355,response to estradiol;GO:0035902,response to immobilization stress;GO:0043278,response to morphine;GO:0035994,response to muscle stretch;GO:0032570,response to progesterone;GO:0033574,response to testosterone	hsa:2821,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:2821,path:hsa00030,Pentose phosphate pathway;hsa:2821,path:hsa00500,Starch and sucrose metabolism;hsa:2821,path:hsa00520,Amino sugar and nucleotide sugar metabolism
ESRP1_HUMAN	Q6NXG1	ESRP1	Epithelial splicing regulatory protein 1	0.320736325	0.208926401	0.390449978	0.05903224	0.264831363	0.224741109	0.264831363	0.224741109	1.17838416023835	0.379726	0	0.848619689353032	0.379418	0	GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:1990904,ribonucleoprotein complex	GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0008543,fibroblast growth factor receptor signaling pathway;GO:0006397,mRNA processing;GO:0042669,regulation of inner ear auditory receptor cell fate specification;GO:0043484,regulation of RNA splicing;GO:0008380,RNA splicing	
MX1_HUMAN	P20591	MX1	Interferon-induced GTP-binding protein Mx1	2.925709869	2.305811498	5.516168566	9.096756497	2.6157606835	7.3064625315	2.6157606835	7.3064625315	0.358006445967908	0.102853	0	2.79324579560682	0.103155	0	GO:0030424,axon;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0044327,dendritic spine head;GO:0005789,endoplasmic reticulum membrane;GO:0016020,membrane;GO:0015630,microtubule cytoskeleton;GO:0031966,mitochondrial membrane;GO:0031965,nuclear membrane;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0098844,postsynaptic endocytic zone membrane;GO:0098793,presynapse	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0008017,microtubule binding	GO:0140374,antiviral innate immune response;GO:0006915,apoptotic process;GO:0006952,defense response;GO:0051607,defense response to virus;GO:0003374,dynamin family protein polymerization involved in mitochondrial fission;GO:0045087,innate immune response;GO:0070106,interleukin-27-mediated signaling pathway;GO:0061025,membrane fusion;GO:0000266,mitochondrial fission;GO:0045071,negative regulation of viral genome replication;GO:0098884,postsynaptic neurotransmitter receptor internalization;GO:0031623,receptor internalization;GO:0050803,regulation of synapse structure or activity;GO:0034340,response to type I interferon;GO:0009615,response to virus;GO:0007165,signal transduction;GO:0016185,synaptic vesicle budding from presynaptic endocytic zone membrane;GO:0060337,type I interferon signaling pathway	hsa:4599,path:hsa05162,Measles;hsa:4599,path:hsa05164,Influenza A;hsa:4599,path:hsa05160,Hepatitis C;hsa:4599,path:hsa05165,Human papillomavirus infection
GOT1B_HUMAN	Q9Y3E0	GOLT1B	Vesicle transport protein GOT1B	0.162168841	0.277815386	0.361762488	0.094329064	0.2199921135	0.228045776	0.2199921135	0.228045776	0.964684009319252	0.445301	0	1.03660886916294	0.445129	0	GO:0005783,endoplasmic reticulum;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0032991,protein-containing complex		GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0015031,protein transport;GO:0016192,vesicle-mediated transport	
EGLN_HUMAN	P17813	ENG	Endoglin	0.077701559	0.282066608	0.202885248	1.350048986	0.1798840835	0.776467117	0.1798840835	0.776467117	0.231669931104114	0.026767	-1	4.31648593856832	0.026918	1	GO:0009986,cell surface;GO:0072563,endothelial microparticle;GO:0009897,external side of plasma membrane;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0016021,integral component of membrane;GO:0016604,nuclear body;GO:0005886,plasma membrane;GO:0043235,receptor complex	GO:0048185,activin binding;GO:0015026,coreceptor activity;GO:0005534,galactose binding;GO:0005539,glycosaminoglycan binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:0050431,transforming growth factor beta binding;GO:0005024,transforming growth factor beta-activated receptor activity;GO:0004888,transmembrane signaling receptor activity;GO:0034713,type I transforming growth factor beta receptor binding;GO:0005114,type II transforming growth factor beta receptor binding	GO:0001525,angiogenesis;GO:0048844,artery morphogenesis;GO:0055009,atrial cardiac muscle tissue morphogenesis;GO:1905222,atrioventricular canal morphogenesis;GO:0030509,BMP signaling pathway;GO:0060348,bone development;GO:0001569,branching involved in blood vessel morphogenesis;GO:0003209,cardiac atrium morphogenesis;GO:0003208,cardiac ventricle morphogenesis;GO:0007155,cell adhesion;GO:0060326,cell chemotaxis;GO:0016477,cell migration;GO:0003273,cell migration involved in endocardial cushion formation;GO:0048870,cell motility;GO:0071260,cellular response to mechanical stimulus;GO:0022009,central nervous system vasculogenesis;GO:0070483,detection of hypoxia;GO:0035912,dorsal aorta morphogenesis;GO:0003203,endocardial cushion morphogenesis;GO:0001837,epithelial to mesenchymal transition;GO:0003198,epithelial to mesenchymal transition involved in endocardial cushion formation;GO:0070278,extracellular matrix constituent secretion;GO:0022617,extracellular matrix disassembly;GO:0001947,heart looping;GO:0030336,negative regulation of cell migration;GO:0001937,negative regulation of endothelial cell proliferation;GO:0010629,negative regulation of gene expression;GO:0051001,negative regulation of nitric-oxide synthase activity;GO:0060394,negative regulation of pathway-restricted SMAD protein phosphorylation;GO:0031953,negative regulation of protein autophosphorylation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0030512,negative regulation of transforming growth factor beta receptor signaling pathway;GO:0003148,outflow tract septum morphogenesis;GO:0045766,positive regulation of angiogenesis;GO:0030513,positive regulation of BMP signaling pathway;GO:0032967,positive regulation of collagen biosynthetic process;GO:1905007,positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation;GO:0010628,positive regulation of gene expression;GO:0010862,positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0051897,positive regulation of protein kinase B signaling;GO:0001934,positive regulation of protein phosphorylation;GO:0003084,positive regulation of systemic arterial blood pressure;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:1905065,positive regulation of vascular associated smooth muscle cell differentiation;GO:0030155,regulation of cell adhesion;GO:0042127,regulation of cell population proliferation;GO:0042325,regulation of phosphorylation;GO:0006355,regulation of transcription, DNA-templated;GO:0017015,regulation of transforming growth factor beta receptor signaling pathway;GO:0031960,response to corticosteroid;GO:0042493,response to drug;GO:0001666,response to hypoxia;GO:0048745,smooth muscle tissue development;GO:0007179,transforming growth factor beta receptor signaling pathway;GO:0097084,vascular associated smooth muscle cell development;GO:0001570,vasculogenesis;GO:0048845,venous blood vessel morphogenesis;GO:0003222,ventricular trabecula myocardium morphogenesis;GO:0042060,wound healing	
PELP1_HUMAN	Q8IZL8	PELP1	Proline-, glutamic acid- and leucine-rich protein 1	1.332307124	0.905222445	1.903445116	1.058852728	1.1187647845	1.481148922	1.1187647845	1.481148922	0.755335785539599	0.450469	0	1.32391450152943	0.450616	0	GO:0005737,cytoplasm;GO:0016020,membrane;GO:0071339,MLL1 complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0035327,transcriptionally active chromatin;GO:0005634,nucleus	GO:0003682,chromatin binding;GO:0003723,RNA binding;GO:0008134,transcription factor binding	GO:0071391,cellular response to estrogen stimulus;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0006364,rRNA processing	
TRA2A_HUMAN	Q13595	TRA2A	Transformer-2 protein homolog alpha	0.42113692	0.433905577	0.675059777	0.171679035	0.4275212485	0.423369406	0.4275212485	0.423369406	1.00980666633243	0.430118	0	0.990288570417103	0.429914	0	GO:0043231,intracellular membrane-bounded organelle;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex	GO:0003723,RNA binding	GO:0000398,mRNA splicing, via spliceosome;GO:0048026,positive regulation of mRNA splicing, via spliceosome	hsa:29896,path:hsa03040,Spliceosome
LIS1_HUMAN	P43034	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit beta	2.000396995	1.870308543	3.120864684	3.506119946	1.935352769	3.313492315	1.935352769	3.313492315	0.584082467986651	0.302435	0	1.71208699937019	0.302721	0	GO:0008247,1-alkyl-2-acetylglycerophosphocholine esterase complex;GO:0000235,astral microtubule;GO:1904115,axon cytoplasm;GO:0005938,cell cortex;GO:0005813,centrosome;GO:0005881,cytoplasmic microtubule;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0000776,kinetochore;GO:0005875,microtubule associated complex;GO:0031514,motile cilium;GO:0043005,neuron projection;GO:0043025,neuronal cell body;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane;GO:0048471,perinuclear region of cytoplasm;GO:0045202,synapse;GO:0005737,cytoplasm;GO:0005874,microtubule;GO:0005815,microtubule organizing center;GO:0005819,spindle;GO:0005634,nucleus	GO:0034452,dynactin binding;GO:0070840,dynein complex binding;GO:0008201,heparin binding;GO:0042802,identical protein binding;GO:0008017,microtubule binding;GO:0051010,microtubule plus-end binding;GO:0043274,phospholipase binding;GO:0051219,phosphoprotein binding;GO:0046982,protein heterodimerization activity	GO:0001675,acrosome assembly;GO:0030036,actin cytoskeleton organization;GO:0008344,adult locomotory behavior;GO:0048854,brain morphogenesis;GO:0051301,cell division;GO:0021987,cerebral cortex development;GO:0007268,chemical synaptic transmission;GO:0097711,ciliary basal body-plasma membrane docking;GO:0021540,corpus callosum morphogenesis;GO:0000132,establishment of mitotic spindle orientation;GO:0000086,G2/M transition of mitotic cell cycle;GO:0007281,germ cell development;GO:0021766,hippocampus development;GO:0021819,layer formation in cerebral cortex;GO:0007611,learning or memory;GO:0016042,lipid catabolic process;GO:0000226,microtubule cytoskeleton organization;GO:0031023,microtubule organizing center organization;GO:0051012,microtubule sliding;GO:0007017,microtubule-based process;GO:0007052,mitotic spindle organization;GO:0007405,neuroblast proliferation;GO:0050885,neuromuscular process controlling balance;GO:0001764,neuron migration;GO:0007097,nuclear migration;GO:0046469,platelet activating factor metabolic process;GO:0038026,reelin-mediated signaling pathway;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:2000574,regulation of microtubule motor activity;GO:0008090,retrograde axonal transport;GO:0019226,transmission of nerve impulse;GO:0047496,vesicle transport along microtubule;GO:0030154,cell differentiation;GO:0007399,nervous system development;GO:0007049,cell cycle	hsa:5048,path:hsa00565,Ether lipid metabolism
FKBP8_HUMAN	Q14318	FKBP8	Peptidyl-prolyl cis-trans isomerase FKBP8	0.092954741	0.079947845	0.179499221	2.55E-05	0.086451293	0.0897623605	0.086451293	0.0897623605	0.963112963144502	0.445843	0	1.03829980310416	0.445674	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0030176,integral component of endoplasmic reticulum membrane;GO:0016020,membrane;GO:0031966,mitochondrial membrane;GO:0005739,mitochondrion;GO:0032991,protein-containing complex;GO:0016021,integral component of membrane	GO:0097718,disordered domain specific binding;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0003755,peptidyl-prolyl cis-trans isomerase activity;GO:0044183,protein folding chaperone	GO:0006915,apoptotic process;GO:0043010,camera-type eye development;GO:0001708,cell fate specification;GO:0021904,dorsal/ventral neural tube patterning;GO:0035556,intracellular signal transduction;GO:0035264,multicellular organism growth;GO:0043066,negative regulation of apoptotic process;GO:0001933,negative regulation of protein phosphorylation;GO:0030513,positive regulation of BMP signaling pathway;GO:0006457,protein folding;GO:0010468,regulation of gene expression;GO:0007224,smoothened signaling pathway;GO:0016032,viral process	
TOM22_HUMAN	Q9NS69	TOMM22	Mitochondrial import receptor subunit TOM22 homolog	1.796676715	1.055456107	0.118027361	2.55E-05	1.426066411	0.0590264305	1.426066411	0.0590264305	24.1597941620407	0.002172	1	0.041391081119854	0.002128	-1	GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005742,mitochondrial outer membrane translocase complex;GO:0005739,mitochondrion	GO:0008320,protein transmembrane transporter activity	GO:0016236,macroautophagy;GO:0043065,positive regulation of apoptotic process;GO:0045040,protein insertion into mitochondrial outer membrane;GO:0006626,protein targeting to mitochondrion	
HEP2_HUMAN	P05546	SERPIND1	Heparin cofactor 2	1.68435748	0.84522304	3.347085128	11.87559327	1.26479026	7.611339199	1.26479026	7.611339199	0.16617184268521	0.007376	-1	6.01786670858771	0.007438	1	GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0004866,endopeptidase inhibitor activity;GO:0008201,heparin binding;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0007596,blood coagulation;GO:0044267,cellular protein metabolic process;GO:0006935,chemotaxis;GO:0010951,negative regulation of endopeptidase activity;GO:0043687,post-translational protein modification	hsa:3053,path:hsa04610,Complement and coagulation cascades
UBE3C_HUMAN	Q15386	UBE3C	Ubiquitin-protein ligase E3C	0.098298734	0.009523814	0.253814577	2.55E-05	0.053911274	0.1269200385	0.053911274	0.1269200385	0.424765660624977	0.157652	0	2.35423927284671	0.157985	0	GO:0005634,nucleus;GO:0000502,proteasome complex	GO:0061630,ubiquitin protein ligase activity	GO:0000209,protein polyubiquitination;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:9690,path:hsa04120,Ubiquitin mediated proteolysis
XPO4_HUMAN	Q9C0E2	XPO4	Exportin-4	0.022652968	0.024853491	0.100134311	0.132919641	0.0237532295	0.116526976	0.0237532295	0.116526976	0.203843181341975	0.016745	-1	4.90573191321205	0.016857	1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005643,nuclear pore;GO:0005654,nucleoplasm	GO:0005049,nuclear export signal receptor activity	GO:0046827,positive regulation of protein export from nucleus;GO:0006611,protein export from nucleus	
PITH1_HUMAN	Q9GZP4	PITHD1	PITH domain-containing protein 1	0.476901793	1.552564702	0.127749274	0.015570018	1.0147332475	0.071659646	1.0147332475	0.071659646	14.160455767532	0.008157	1	0.0706191959084301	0.008035	-1	GO:0005737,cytoplasm;GO:0005634,nucleus;GO:0097598,sperm cytoplasmic droplet		GO:0061956,penetration of cumulus oophorus;GO:0007341,penetration of zona pellucida;GO:0045654,positive regulation of megakaryocyte differentiation;GO:0045893,positive regulation of transcription, DNA-templated;GO:0061136,regulation of proteasomal protein catabolic process;GO:0007286,spermatid development	
MCM3_HUMAN	P25205	MCM3	DNA replication licensing factor MCM3	1.313754585	0.47935627	1.252911367	1.793454558	0.8965554275	1.5231829625	0.8965554275	1.5231829625	0.588606523032849	0.306562	0	1.69892782507303	0.306845	0	GO:0005658,alpha DNA polymerase;GO:0005813,centrosome;GO:0000781,chromosome, telomeric region;GO:0071162,CMG complex;GO:0042555,MCM complex;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005694,chromosome	GO:0005524,ATP binding;GO:0003677,DNA binding;GO:0003678,DNA helicase activity;GO:0003688,DNA replication origin binding;GO:0016787,hydrolase activity;GO:0003697,single-stranded DNA binding	GO:0006260,DNA replication;GO:0006270,DNA replication initiation;GO:0006271,DNA strand elongation involved in DNA replication;GO:0000727,double-strand break repair via break-induced replication;GO:1902975,mitotic DNA replication initiation;GO:0036388,pre-replicative complex assembly;GO:0006267,pre-replicative complex assembly involved in nuclear cell cycle DNA replication;GO:0032508,DNA duplex unwinding;GO:0007049,cell cycle	hsa:4172,path:hsa03030,DNA replication;hsa:4172,path:hsa04110,Cell cycle
MPI_HUMAN	P34949	MPI	Mannose-6-phosphate isomerase	0.214135595	0.062079368	0.460516992	0.088610048	0.1381074815	0.27456352	0.1381074815	0.27456352	0.503007396976845	0.227899	0	1.98804233498386	0.228227	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0004476,mannose-6-phosphate isomerase activity;GO:0008270,zinc ion binding	GO:0009298,GDP-mannose biosynthetic process;GO:0061611,mannose to fructose-6-phosphate metabolic process;GO:0006486,protein glycosylation;GO:0005975,carbohydrate metabolic process	hsa:4351,path:hsa00051,Fructose and mannose metabolism;hsa:4351,path:hsa00520,Amino sugar and nucleotide sugar metabolism
GPNMB_HUMAN	Q14956	GPNMB	Transmembrane glycoprotein NMB	4.672547825	19.05738804	6.510086838	8.57786409	11.8649679325	7.543975464	11.8649679325	7.543975464	1.57277392922602	0.291320	0	0.635819288085547	0.290857	0	GO:0031901,early endosome membrane;GO:0016021,integral component of membrane;GO:0005887,integral component of plasma membrane;GO:0033162,melanosome membrane;GO:0005886,plasma membrane	GO:0042056,chemoattractant activity;GO:0008201,heparin binding;GO:0005178,integrin binding;GO:0048018,receptor ligand activity;GO:0045545,syndecan binding	GO:0007155,cell adhesion;GO:0007267,cell-cell signaling;GO:0008285,negative regulation of cell population proliferation;GO:0001818,negative regulation of cytokine production;GO:2000134,negative regulation of G1/S transition of mitotic cell cycle;GO:1901215,negative regulation of neuron death;GO:0050868,negative regulation of T cell activation;GO:0042130,negative regulation of T cell proliferation;GO:0050918,positive chemotaxis;GO:0030335,positive regulation of cell migration;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0031954,positive regulation of protein autophosphorylation;GO:0001934,positive regulation of protein phosphorylation;GO:0045765,regulation of angiogenesis;GO:0034103,regulation of tissue remodeling;GO:0007165,signal transduction;GO:0030282,bone mineralization;GO:0001649,osteoblast differentiation	
RAD50_HUMAN	Q92878	RAD50	DNA repair protein RAD50	0.640962505	0.846941144	0.830255814	0.711373655	0.7439518245	0.7708147345	0.7439518245	0.7708147345	0.965149978590608	0.445140	0	1.03610839991965	0.444968	0	GO:0000781,chromosome, telomeric region;GO:0000794,condensed nuclear chromosome;GO:0016020,membrane;GO:0030870,Mre11 complex;GO:0005654,nucleoplasm;GO:0035861,site of double-strand break	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0003677,DNA binding;GO:0003691,double-stranded telomeric DNA binding;GO:0051880,G-quadruplex DNA binding;GO:0016787,hydrolase activity;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0030674,protein-macromolecule adaptor activity;GO:0043047,single-stranded telomeric DNA binding	GO:0006974,cellular response to DNA damage stimulus;GO:0070192,chromosome organization involved in meiotic cell cycle;GO:0000729,DNA double-strand break processing;GO:0032508,DNA duplex unwinding;GO:0006310,DNA recombination;GO:0006281,DNA repair;GO:0006260,DNA replication;GO:0006302,double-strand break repair;GO:0000724,double-strand break repair via homologous recombination;GO:0006303,double-strand break repair via nonhomologous end joining;GO:1904354,negative regulation of telomere capping;GO:0090305,nucleic acid phosphodiester bond hydrolysis;GO:0033674,positive regulation of kinase activity;GO:0031954,positive regulation of protein autophosphorylation;GO:0032206,positive regulation of telomere maintenance;GO:0007131,reciprocal meiotic recombination;GO:0000019,regulation of mitotic recombination;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0000723,telomere maintenance;GO:0000722,telomere maintenance via recombination;GO:0007004,telomere maintenance via telomerase;GO:0031860,telomeric 3' overhang formation;GO:0016032,viral process	hsa:10111,path:hsa03440,Homologous recombination;hsa:10111,path:hsa03450,Non-homologous end-joining;hsa:10111,path:hsa04218,Cellular senescence
2A5E_HUMAN	Q16537	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	0.15282781	0.064763322	0.237989594	0.159029442	0.108795566	0.198509518	0.108795566	0.198509518	0.54806221432667	0.269381	0	1.82461037061014	0.269689	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus;GO:0000159,protein phosphatase type 2A complex	GO:0072542,protein phosphatase activator activity;GO:0019888,protein phosphatase regulator activity	GO:0006470,protein dephosphorylation;GO:0031952,regulation of protein autophosphorylation;GO:0007165,signal transduction	hsa:5529,path:hsa03015,mRNA surveillance pathway;hsa:5529,path:hsa04071,Sphingolipid signaling pathway;hsa:5529,path:hsa04151,PI3K-Akt signaling pathway;hsa:5529,path:hsa04152,AMPK signaling pathway;hsa:5529,path:hsa04114,Oocyte meiosis;hsa:5529,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:5529,path:hsa04728,Dopaminergic synapse;hsa:5529,path:hsa05165,Human papillomavirus infection
CILP1_HUMAN	O75339	CILP	Cartilage intermediate layer protein 1	0.176162052	0.467731715	0.249316749	0.163243767	0.3219468835	0.206280258	0.3219468835	0.206280258	1.56072561970521	0.293548	0	0.640727612447909	0.293087	0	GO:0062023,collagen-containing extracellular matrix;GO:0070062,extracellular exosome;GO:0005615,extracellular space		GO:0071560,cellular response to transforming growth factor beta stimulus;GO:0016311,dephosphorylation;GO:0010629,negative regulation of gene expression;GO:0043569,negative regulation of insulin-like growth factor receptor signaling pathway;GO:0060392,negative regulation of SMAD protein signal transduction	
HBG1_HUMAN	P69891	HBG1	Hemoglobin subunit gamma-1	1.958809821	3.55860923	5.69661526	39.95775505	2.7587095255	22.827185155	2.7587095255	22.827185155	0.12085193626669	0.001722	-1	8.27458815217695	0.001742	1	GO:0005829,cytosol;GO:0031838,haptoglobin-hemoglobin complex;GO:0005833,hemoglobin complex	GO:0020037,heme binding;GO:0031721,hemoglobin alpha binding;GO:0046872,metal ion binding;GO:0043177,organic acid binding;GO:0019825,oxygen binding;GO:0005344,oxygen carrier activity	GO:0007596,blood coagulation;GO:0098869,cellular oxidant detoxification;GO:0042744,hydrogen peroxide catabolic process	
NP1L1_HUMAN	P55209	NAP1L1	Nucleosome assembly protein 1-like 1	1.185685165	1.302629338	1.923014456	1.816059889	1.2441572515	1.8695371725	1.2441572515	1.8695371725	0.665489442949282	0.375239	0	1.50265343890093	0.375464	0	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0042470,melanosome;GO:0016020,membrane;GO:0005634,nucleus	GO:0003682,chromatin binding;GO:0042393,histone binding;GO:0003723,RNA binding	GO:0006260,DNA replication;GO:0006334,nucleosome assembly;GO:0008284,positive regulation of cell population proliferation;GO:2000179,positive regulation of neural precursor cell proliferation;GO:0050769,positive regulation of neurogenesis	
KSYK_HUMAN	P43405	SYK	Tyrosine-protein kinase SYK	0.40498669	0.365545975	0.60963684	0.303313773	0.3852663325	0.4564753065	0.3852663325	0.4564753065	0.844002571473162	0.490068	0	1.18483051331769	0.489995	0	GO:0019815,B cell receptor complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0032009,early phagosome;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0042101,T cell receptor complex	GO:0005524,ATP binding;GO:0005178,integrin binding;GO:0016170,interleukin-15 receptor binding;GO:0004715,non-membrane spanning protein tyrosine kinase activity;GO:0019902,phosphatase binding;GO:0001784,phosphotyrosine residue binding;GO:0004672,protein kinase activity;GO:0019901,protein kinase binding;GO:0004674,protein serine/threonine kinase activity;GO:0004713,protein tyrosine kinase activity;GO:0097110,scaffold protein binding;GO:0042169,SH2 domain binding;GO:0005102,signaling receptor binding;GO:0035325,Toll-like receptor binding;GO:0004714,transmembrane receptor protein tyrosine kinase activity	GO:0007257,activation of JUN kinase activity;GO:0002250,adaptive immune response;GO:0001525,angiogenesis;GO:0009887,animal organ morphogenesis;GO:0050853,B cell receptor signaling pathway;GO:0043366,beta selection;GO:0048514,blood vessel morphogenesis;GO:0030154,cell differentiation;GO:0071404,cellular response to low-density lipoprotein particle stimulus;GO:0071226,cellular response to molecule of fungal origin;GO:0038063,collagen-activated tyrosine kinase receptor signaling pathway;GO:0019221,cytokine-mediated signaling pathway;GO:0042742,defense response to bacterium;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0045087,innate immune response;GO:0007229,integrin-mediated signaling pathway;GO:0038110,interleukin-2-mediated signaling pathway;GO:0038156,interleukin-3-mediated signaling pathway;GO:0035556,intracellular signal transduction;GO:0002366,leukocyte activation involved in immune response;GO:0007159,leukocyte cell-cell adhesion;GO:0019370,leukotriene biosynthetic process;GO:0001945,lymph vessel development;GO:0002281,macrophage activation involved in immune response;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0002283,neutrophil activation involved in immune response;GO:0030593,neutrophil chemotaxis;GO:0018105,peptidyl-serine phosphorylation;GO:0018108,peptidyl-tyrosine phosphorylation;GO:0030168,platelet activation;GO:0046638,positive regulation of alpha-beta T cell differentiation;GO:0046641,positive regulation of alpha-beta T cell proliferation;GO:0045579,positive regulation of B cell differentiation;GO:0045780,positive regulation of bone resorption;GO:0050850,positive regulation of calcium-mediated signaling;GO:0033630,positive regulation of cell adhesion mediated by integrin;GO:0120162,positive regulation of cold-induced thermogenesis;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045588,positive regulation of gamma-delta T cell differentiation;GO:0032725,positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0032733,positive regulation of interleukin-10 production;GO:0032735,positive regulation of interleukin-12 production;GO:0032752,positive regulation of interleukin-3 production;GO:0032753,positive regulation of interleukin-4 production;GO:0032755,positive regulation of interleukin-6 production;GO:0032757,positive regulation of interleukin-8 production;GO:0051712,positive regulation of killing of cells of other organism;GO:0043306,positive regulation of mast cell degranulation;GO:0071639,positive regulation of monocyte chemotactic protein-1 production;GO:0050731,positive regulation of peptidyl-tyrosine phosphorylation;GO:0031334,positive regulation of protein-containing complex assembly;GO:0002092,positive regulation of receptor internalization;GO:0032930,positive regulation of superoxide anion generation;GO:0032760,positive regulation of tumor necrosis factor production;GO:0032481,positive regulation of type I interferon production;GO:0046777,protein autophosphorylation;GO:0006606,protein import into nucleus;GO:0006468,protein phosphorylation;GO:0031623,receptor internalization;GO:0090237,regulation of arachidonic acid secretion;GO:0051090,regulation of DNA-binding transcription factor activity;GO:0070372,regulation of ERK1 and ERK2 cascade;GO:0043313,regulation of neutrophil degranulation;GO:0050764,regulation of phagocytosis;GO:0010543,regulation of platelet activation;GO:0090330,regulation of platelet aggregation;GO:0032928,regulation of superoxide anion generation;GO:0010803,regulation of tumor necrosis factor-mediated signaling pathway;GO:0002554,serotonin secretion by platelet;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0007169,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0016032,viral process	hsa:6850,path:hsa04064,NF-kappa B signaling pathway;hsa:6850,path:hsa04072,Phospholipase D signaling pathway;hsa:6850,path:hsa04151,PI3K-Akt signaling pathway;hsa:6850,path:hsa04611,Platelet activation;hsa:6850,path:hsa04625,C-type lectin receptor signaling pathway;hsa:6850,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:6850,path:hsa04662,B cell receptor signaling pathway;hsa:6850,path:hsa04664,Fc epsilon RI signaling pathway;hsa:6850,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:6850,path:hsa04380,Osteoclast differentiation;hsa:6850,path:hsa05203,Viral carcinogenesis;hsa:6850,path:hsa05152,Tuberculosis;hsa:6850,path:hsa05168,Herpes simplex virus 1 infection;hsa:6850,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:6850,path:hsa05169,Epstein-Barr virus infection
AP1M2_HUMAN	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.233730798	0.196399983	0.229484508	0.192815017	0.2150653905	0.2111497625	0.2150653905	0.2111497625	1.01854431638302	0.427267	0	0.98179331415949	0.427057	0	GO:0030131,clathrin adaptor complex;GO:0030136,clathrin-coated vesicle;GO:0030665,clathrin-coated vesicle membrane;GO:0031410,cytoplasmic vesicle;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0000139,Golgi membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0005765,lysosomal membrane;GO:0032588,trans-Golgi network membrane	GO:0035615,clathrin adaptor activity	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0006892,post-Golgi vesicle-mediated transport;GO:0006605,protein targeting;GO:0050690,regulation of defense response to virus by virus;GO:0006903,vesicle targeting;GO:0016192,vesicle-mediated transport;GO:0006886,intracellular protein transport	hsa:10053,path:hsa04142,Lysosome;hsa:10053,path:hsa05170,Human immunodeficiency virus 1 infection
P5CR1_HUMAN	P32322	PYCR1	Pyrroline-5-carboxylate reductase 1, mitochondrial	0.669748342	0.156837502	0.273610612	0.214280465	0.413292922	0.2439455385	0.413292922	0.2439455385	1.69420160147754	0.270197	0	0.590248527169309	0.269704	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0042802,identical protein binding;GO:0004735,pyrroline-5-carboxylate reductase activity	GO:0034599,cellular response to oxidative stress;GO:0009064,glutamine family amino acid metabolic process;GO:0055129,L-proline biosynthetic process;GO:1903206,negative regulation of hydrogen peroxide-induced cell death;GO:0006561,proline biosynthetic process;GO:0051881,regulation of mitochondrial membrane potential;GO:0008652,cellular amino acid biosynthetic process	hsa:5831,path:hsa00330,Arginine and proline metabolism
ADHX_HUMAN	P11766	ADH5	Alcohol dehydrogenase class-3	2.943407566	3.518002088	4.855818503	5.255248895	3.230704827	5.055533699	3.230704827	5.055533699	0.639043277990421	0.351981	0	1.56483924397839	0.352227	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005739,mitochondrion	GO:0004024,alcohol dehydrogenase activity, zinc-dependent;GO:0009055,electron transfer activity;GO:0005504,fatty acid binding;GO:0018467,formaldehyde dehydrogenase activity;GO:0042802,identical protein binding;GO:0051903,S-(hydroxymethyl)glutathione dehydrogenase activity;GO:0106322,S-(hydroxymethyl)glutathione dehydrogenase NAD activity;GO:0106321,S-(hydroxymethyl)glutathione dehydrogenase NADP activity;GO:0008270,zinc ion binding;GO:0016491,oxidoreductase activity	GO:0006069,ethanol oxidation;GO:0010430,fatty acid omega-oxidation;GO:0046294,formaldehyde catabolic process;GO:0018119,peptidyl-cysteine S-nitrosylation;GO:0045777,positive regulation of blood pressure;GO:0003016,respiratory system process;GO:0032496,response to lipopolysaccharide;GO:0051409,response to nitrosative stress;GO:0051775,response to redox state;GO:0001523,retinoid metabolic process	hsa:128,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:128,path:hsa00071,Fatty acid degradation;hsa:128,path:hsa00350,Tyrosine metabolism;hsa:128,path:hsa00830,Retinol metabolism;hsa:128,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:128,path:hsa00982,Drug metabolism - cytochrome P450;hsa:128,path:hsa05204,Chemical carcinogenesis
OLFL3_HUMAN	Q9NRN5	OLFML3	Olfactomedin-like protein 3	0.129082651	0.23407362	0.720890596	2.281125091	0.1815781355	1.5010078435	0.1815781355	1.5010078435	0.120970810569918	0.001730	-1	8.26645696832811	0.001750	1	GO:1903561,extracellular vesicle;GO:0005576,extracellular region		GO:0007275,multicellular organism development	
GLPK_HUMAN	P32189	GK	Glycerol kinase	0.365088336	0.19992595	0.234904204	0.088729775	0.282507143	0.1618169895	0.282507143	0.1618169895	1.74584352281501	0.261892	0	0.572789019709849	0.261388	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0004370,glycerol kinase activity;GO:0016773,phosphotransferase activity, alcohol group as acceptor	GO:0019563,glycerol catabolic process;GO:0006071,glycerol metabolic process;GO:0046167,glycerol-3-phosphate biosynthetic process;GO:0016310,phosphorylation;GO:0019432,triglyceride biosynthetic process;GO:0006641,triglyceride metabolic process;GO:0005975,carbohydrate metabolic process	hsa:2710,path:hsa00561,Glycerolipid metabolism;hsa:2710,path:hsa03320,PPAR signaling pathway
RAB5A_HUMAN	P20339	RAB5A	Ras-related protein Rab-5A	1.010568568	2.509266816	0.172055849	0.231536796	1.759917692	0.2017963225	1.759917692	0.2017963225	8.72125750458114	0.023115	1	0.114662363710132	0.022866	-1	GO:0015629,actin cytoskeleton;GO:0098993,anchored component of synaptic vesicle membrane;GO:0030424,axon;GO:0043679,axon terminus;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0005737,cytoplasm;GO:0098559,cytoplasmic side of early endosome membrane;GO:0005829,cytosol;GO:0030425,dendrite;GO:0005769,early endosome;GO:0031901,early endosome membrane;GO:0032009,early phagosome;GO:0030139,endocytic vesicle;GO:0012505,endomembrane system;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0043231,intracellular membrane-bounded organelle;GO:0042470,melanosome;GO:0045121,membrane raft;GO:0043025,neuronal cell body;GO:0005654,nucleoplasm;GO:0045335,phagocytic vesicle;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0098842,postsynaptic early endosome;GO:0001726,ruffle;GO:0036477,somatodendritic compartment;GO:0008021,synaptic vesicle;GO:0043195,terminal bouton	GO:0003925,G protein activity;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0150093,amyloid-beta clearance by transcytosis;GO:0007596,blood coagulation;GO:0045022,early endosome to late endosome transport;GO:0006897,endocytosis;GO:0006886,intracellular protein transport;GO:0061024,membrane organization;GO:0006909,phagocytosis;GO:0006661,phosphatidylinositol biosynthetic process;GO:0045921,positive regulation of exocytosis;GO:0043687,post-translational protein modification;GO:2000286,receptor internalization involved in canonical Wnt signaling pathway;GO:2000785,regulation of autophagosome assembly;GO:0030100,regulation of endocytosis;GO:0051036,regulation of endosome size;GO:0051489,regulation of filopodium assembly;GO:0048169,regulation of long-term neuronal synaptic plasticity;GO:2000300,regulation of synaptic vesicle exocytosis;GO:0036465,synaptic vesicle recycling;GO:0039694,viral RNA genome replication	hsa:5868,path:hsa04014,Ras signaling pathway;hsa:5868,path:hsa04144,Endocytosis;hsa:5868,path:hsa04145,Phagosome;hsa:5868,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:5868,path:hsa05014,Amyotrophic lateral sclerosis (ALS);hsa:5868,path:hsa05132,Salmonella infection;hsa:5868,path:hsa05152,Tuberculosis;hsa:5868,path:hsa05146,Amoebiasis
ANXA4_HUMAN	P09525	ANXA4	Annexin A4	9.937818429	22.71540165	15.12246641	21.39865549	16.3266100395	18.26056095	16.3266100395	18.26056095	0.894091374531405	0.470707	0	1.11845391699937	0.470592	0	GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0031965,nuclear membrane;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0012506,vesicle membrane	GO:0005509,calcium ion binding;GO:0005544,calcium-dependent phospholipid binding;GO:0048306,calcium-dependent protein binding;GO:0042802,identical protein binding;GO:0051059,NF-kappaB binding;GO:0004859,phospholipase inhibitor activity	GO:0030855,epithelial cell differentiation;GO:0043066,negative regulation of apoptotic process;GO:0032717,negative regulation of interleukin-8 production;GO:0032088,negative regulation of NF-kappaB transcription factor activity;GO:0007219,Notch signaling pathway;GO:0006357,regulation of transcription by RNA polymerase II;GO:0007165,signal transduction;GO:0050819,negative regulation of coagulation	
LMNB1_HUMAN	P20700	LMNB1	Lamin-B1	18.32123764	8.831974739	20.67091854	23.35419567	13.5766061895	22.012557105	13.5766061895	22.012557105	0.616766426759941	0.332071	0	1.62135932925743	0.332334	0	GO:0005638,lamin filament;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0005637,nuclear inner membrane;GO:0016363,nuclear matrix;GO:0031965,nuclear membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005882,intermediate filament	GO:0043274,phospholipase binding;GO:1990837,sequence-specific double-stranded DNA binding;GO:0005198,structural molecule activity	GO:0035722,interleukin-12-mediated signaling pathway	hsa:4001,path:hsa04210,Apoptosis
COPE_HUMAN	O14579	COPE	Coatomer subunit epsilon	1.45218818	0.761107219	1.744826008	0.875186868	1.1066476995	1.310006438	1.1066476995	1.310006438	0.844765084658309	0.489764	0	1.18376104571661	0.489691	0	GO:0030126,COPI vesicle coat;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0005654,nucleoplasm;GO:0030133,transport vesicle;GO:0031410,cytoplasmic vesicle;GO:0016020,membrane;GO:0030137,COPI-coated vesicle	GO:0005198,structural molecule activity	GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006891,intra-Golgi vesicle-mediated transport;GO:0015031,protein transport;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0099612,protein localization to axon	
PP1A_HUMAN	P62136	PPP1CA	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	4.58391255	4.000245176	4.9113648	7.016367848	4.292078863	5.963866324	4.292078863	5.963866324	0.719680594738964	0.421377	0	1.38950529903159	0.421555	0	GO:0005912,adherens junction;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043197,dendritic spine;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0042587,glycogen granule;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0043204,perikaryon;GO:0005886,plasma membrane;GO:0098793,presynapse;GO:0000164,protein phosphatase type 1 complex;GO:0072357,PTW/PP1 phosphatase complex	GO:0098641,cadherin binding involved in cell-cell adhesion;GO:0046872,metal ion binding;GO:0016791,phosphatase activity;GO:0004721,phosphoprotein phosphatase activity;GO:0008157,protein phosphatase 1 binding;GO:0106306,protein serine phosphatase activity;GO:0004722,protein serine/threonine phosphatase activity;GO:0106307,protein threonine phosphatase activity;GO:0043021,ribonucleoprotein complex binding	GO:1904886,beta-catenin destruction complex disassembly;GO:0048754,branching morphogenesis of an epithelial tube;GO:0007049,cell cycle;GO:0051301,cell division;GO:0032922,circadian regulation of gene expression;GO:0016311,dephosphorylation;GO:0043153,entrainment of circadian clock by photoperiod;GO:0005977,glycogen metabolic process;GO:0030324,lung development;GO:0032091,negative regulation of protein binding;GO:0070262,peptidyl-serine dephosphorylation;GO:0035970,peptidyl-threonine dephosphorylation;GO:2001241,positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0006470,protein dephosphorylation;GO:0060828,regulation of canonical Wnt signaling pathway;GO:0042752,regulation of circadian rhythm;GO:0005979,regulation of glycogen biosynthetic process;GO:0005981,regulation of glycogen catabolic process;GO:0036496,regulation of translational initiation by eIF2 alpha dephosphorylation;GO:0010288,response to lead ion;GO:0016032,viral process	hsa:5499,path:hsa03015,mRNA surveillance pathway;hsa:5499,path:hsa04390,Hippo signaling pathway;hsa:5499,path:hsa04024,cAMP signaling pathway;hsa:5499,path:hsa04022,cGMP-PKG signaling pathway;hsa:5499,path:hsa04114,Oocyte meiosis;hsa:5499,path:hsa04218,Cellular senescence;hsa:5499,path:hsa04510,Focal adhesion;hsa:5499,path:hsa04810,Regulation of actin cytoskeleton;hsa:5499,path:hsa04611,Platelet activation;hsa:5499,path:hsa04910,Insulin signaling pathway;hsa:5499,path:hsa04921,Oxytocin signaling pathway;hsa:5499,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:5499,path:hsa04270,Vascular smooth muscle contraction;hsa:5499,path:hsa04728,Dopaminergic synapse;hsa:5499,path:hsa04720,Long-term potentiation;hsa:5499,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:5499,path:hsa05205,Proteoglycans in cancer;hsa:5499,path:hsa05031,Amphetamine addiction;hsa:5499,path:hsa05034,Alcoholism;hsa:5499,path:hsa04931,Insulin resistance;hsa:5499,path:hsa05168,Herpes simplex virus 1 infection
DX39A_HUMAN	O00148	DDX39A	ATP-dependent RNA helicase DDX39A	0.215090415	0.197832218	0.56881583	0.063528595	0.2064613165	0.3161722125	0.2064613165	0.3161722125	0.653002725532055	0.364312	0	1.53138717634788	0.364548	0	GO:0005737,cytoplasm;GO:0016020,membrane;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0042802,identical protein binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0003676,nucleic acid binding;GO:0016787,hydrolase activity	GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0006405,RNA export from nucleus	
ACTBM_HUMAN	Q9BYX7	POTEKP	Putative beta-actin-like protein 3	0.34383236	0.602623841	0.017039024	2.55E-05	0.4732281005	0.008532262	0.4732281005	0.008532262	55.4633812815406	0.000191	1	0.0180299140963629	0.000185	-1	GO:0005884,actin filament;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region	GO:0005524,ATP binding;GO:0098973,structural constituent of postsynaptic actin cytoskeleton	GO:0002576,platelet degranulation	
TPC_HUMAN	Q9HC21	SLC25A19	Mitochondrial thiamine pyrophosphate carrier	0.268576971	0.503875439	0.446938681	0.111086504	0.386226205	0.2790125925	0.386226205	0.2790125925	1.38426083761793	0.329274	0	0.722407203053454	0.328871	0	GO:0031305,integral component of mitochondrial inner membrane;GO:0005743,mitochondrial inner membrane;GO:0005634,nucleus;GO:0016021,integral component of membrane	GO:0030233,deoxynucleotide transmembrane transporter activity;GO:0015234,thiamine transmembrane transporter activity	GO:0030302,deoxynucleotide transport;GO:0030974,thiamine pyrophosphate transmembrane transport;GO:0042723,thiamine-containing compound metabolic process	
SSRD_HUMAN	P51571	SSR4	Translocon-associated protein subunit delta	44.11358477	20.06617901	10.25202623	5.174024511	32.08988189	7.7130253705	32.08988189	7.7130253705	4.1604792346119	0.085428	0	0.240356926115816	0.084932	0	GO:0012505,endomembrane system;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005784,Sec61 translocon complex;GO:0005789,endoplasmic reticulum membrane			hsa:6748,path:hsa04141,Protein processing in endoplasmic reticulum
SRP68_HUMAN	Q9UHB9	SRP68	Signal recognition particle subunit SRP68	2.548010605	1.969180618	2.379864578	1.683944218	2.2585956115	2.031904398	2.2585956115	2.031904398	1.11156588554222	0.398590	0	0.899631783420739	0.398320	0	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005925,focal adhesion;GO:0005730,nucleolus;GO:0005840,ribosome;GO:0048500,signal recognition particle;GO:0005786,signal recognition particle, endoplasmic reticulum targeting	GO:0008312,7S RNA binding;GO:0030942,endoplasmic reticulum signal peptide binding;GO:0019904,protein domain specific binding;GO:0003723,RNA binding;GO:0005047,signal recognition particle binding	GO:0042493,response to drug;GO:0006614,SRP-dependent cotranslational protein targeting to membrane	hsa:6730,path:hsa03060,Protein export
AT1B3_HUMAN	P54709	ATP1B3	Sodium/potassium-transporting ATPase subunit beta-3	1.39240954	0.994710594	2.372878128	1.90260488	1.193560067	2.137741504	1.193560067	2.137741504	0.558327592352345	0.278827	0	1.7910631924652	0.279130	0	GO:0016324,apical plasma membrane;GO:0016323,basolateral plasma membrane;GO:0005901,caveola;GO:0070062,extracellular exosome;GO:0042470,melanosome;GO:0005886,plasma membrane;GO:0005890,sodium;GO:0036126,sperm flagellum	GO:0001671,ATPase activator activity;GO:0051117,ATPase binding;GO:0005391,P-type sodium;GO:0030674,protein-macromolecule adaptor activity	GO:0030007,cellular potassium ion homeostasis;GO:0006883,cellular sodium ion homeostasis;GO:0034220,ion transmembrane transport;GO:0050900,leukocyte migration;GO:0086009,membrane repolarization;GO:0032781,positive regulation of ATPase activity;GO:1903288,positive regulation of potassium ion import across plasma membrane;GO:1901018,positive regulation of potassium ion transmembrane transporter activity;GO:1903278,positive regulation of sodium ion export across plasma membrane;GO:1990573,potassium ion import across plasma membrane;GO:0071805,potassium ion transmembrane transport;GO:0072659,protein localization to plasma membrane;GO:0050821,protein stabilization;GO:1903779,regulation of cardiac conduction;GO:0036376,sodium ion export across plasma membrane;GO:0035725,sodium ion transmembrane transport;GO:0006813,potassium ion transport;GO:0006814,sodium ion transport	hsa:483,path:hsa04024,cAMP signaling pathway;hsa:483,path:hsa04022,cGMP-PKG signaling pathway;hsa:483,path:hsa04911,Insulin secretion;hsa:483,path:hsa04918,Thyroid hormone synthesis;hsa:483,path:hsa04919,Thyroid hormone signaling pathway;hsa:483,path:hsa04925,Aldosterone synthesis and secretion;hsa:483,path:hsa04260,Cardiac muscle contraction;hsa:483,path:hsa04261,Adrenergic signaling in cardiomyocytes;hsa:483,path:hsa04970,Salivary secretion;hsa:483,path:hsa04971,Gastric acid secretion;hsa:483,path:hsa04972,Pancreatic secretion;hsa:483,path:hsa04976,Bile secretion;hsa:483,path:hsa04973,Carbohydrate digestion and absorption;hsa:483,path:hsa04974,Protein digestion and absorption;hsa:483,path:hsa04978,Mineral absorption;hsa:483,path:hsa04960,Aldosterone-regulated sodium reabsorption;hsa:483,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:483,path:hsa04964,Proximal tubule bicarbonate reclamation
OGT1_HUMAN	O15294	OGT	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit	0.311387745	0.285912553	0.567784875	0.112074078	0.298650149	0.3399294765	0.298650149	0.3399294765	0.878565024942754	0.476585	0	1.13821967823629	0.476482	0	GO:0042995,cell projection;GO:0005829,cytosol;GO:0000123,histone acetyltransferase complex;GO:0031966,mitochondrial membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0017122,protein N-acetylglucosaminyltransferase complex;GO:0032991,protein-containing complex	GO:0008375,acetylglucosaminyltransferase activity;GO:0005547,phosphatidylinositol-3,4,5-trisphosphate binding;GO:0016262,protein N-acetylglucosaminyltransferase activity;GO:0097363,protein O-GlcNAc transferase activity;GO:0016757,transferase activity, transferring glycosyl groups	GO:0006915,apoptotic process;GO:0032922,circadian regulation of gene expression;GO:0080182,histone H3-K4 trimethylation;GO:0043984,histone H4-K16 acetylation;GO:0043981,histone H4-K5 acetylation;GO:0043982,histone H4-K8 acetylation;GO:0032435,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0031397,negative regulation of protein ubiquitination;GO:0048015,phosphatidylinositol-mediated signaling;GO:0120162,positive regulation of cold-induced thermogenesis;GO:0061087,positive regulation of histone H3-K27 methylation;GO:0045862,positive regulation of proteolysis;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0016579,protein deubiquitination;GO:0006493,protein O-linked glycosylation;GO:0016485,protein processing;GO:0006111,regulation of gluconeogenesis;GO:0006110,regulation of glycolytic process;GO:0046626,regulation of insulin receptor signaling pathway;GO:0060544,regulation of necroptotic process;GO:0035020,regulation of Rac protein signal transduction;GO:0006357,regulation of transcription by RNA polymerase II;GO:0032868,response to insulin;GO:0007584,response to nutrient;GO:0007165,signal transduction;GO:0016032,viral process	hsa:8473,path:hsa00514,Other types of O-glycan biosynthesis;hsa:8473,path:hsa04931,Insulin resistance
STX5_HUMAN	Q13190	STX5	Syntaxin-5	0.038764706	0.022912224	0.073705796	2.55E-05	0.030838465	0.036865648	0.030838465	0.036865648	0.836509506085448	0.493066	0	1.1954436772388	0.493000	0	GO:0005829,cytosol;GO:0012505,endomembrane system;GO:0005789,endoplasmic reticulum membrane;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0031201,SNARE complex;GO:0031982,vesicle;GO:0016020,membrane	GO:0045296,cadherin binding;GO:0047485,protein N-terminus binding;GO:0005484,SNAP receptor activity;GO:0000149,SNARE binding	GO:0048208,COPII vesicle coating;GO:0034498,early endosome to Golgi transport;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0090166,Golgi disassembly;GO:0006886,intracellular protein transport;GO:0045732,positive regulation of protein catabolic process;GO:0045048,protein insertion into ER membrane;GO:1903358,regulation of Golgi organization;GO:0042147,retrograde transport, endosome to Golgi;GO:0048278,vesicle docking;GO:0006906,vesicle fusion;GO:0048280,vesicle fusion with Golgi apparatus;GO:0016192,vesicle-mediated transport	hsa:6811,path:hsa04130,SNARE interactions in vesicular transport
CAN2_HUMAN	P17655	CAPN2	Calpain-2 catalytic subunit	4.615416696	3.967685726	5.065976716	7.024659488	4.291551211	6.045318102	4.291551211	6.045318102	0.709896673523302	0.413212	0	1.40865570624085	0.413398	0	GO:0000785,chromatin;GO:0030864,cortical actin cytoskeleton;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0005783,endoplasmic reticulum;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0005764,lysosome;GO:0045121,membrane raft;GO:0005758,mitochondrial intermembrane space;GO:0043025,neuronal cell body;GO:0005634,nucleus;GO:0097038,perinuclear endoplasmic reticulum;GO:0005886,plasma membrane;GO:0031143,pseudopodium	GO:0005509,calcium ion binding;GO:0004198,calcium-dependent cysteine-type endopeptidase activity;GO:0008234,cysteine-type peptidase activity;GO:0008092,cytoskeletal protein binding;GO:0019899,enzyme binding;GO:0044877,protein-containing complex binding	GO:0048266,behavioral response to pain;GO:0001824,blastocyst development;GO:0071230,cellular response to amino acid stimulus;GO:0035458,cellular response to interferon-beta;GO:0071222,cellular response to lipopolysaccharide;GO:0022617,extracellular matrix disassembly;GO:0007565,female pregnancy;GO:0007520,myoblast fusion;GO:0010666,positive regulation of cardiac muscle cell apoptotic process;GO:1901741,positive regulation of myoblast fusion;GO:1901216,positive regulation of neuron death;GO:2001247,positive regulation of phosphatidylcholine biosynthetic process;GO:0016540,protein autoprocessing;GO:0006508,proteolysis;GO:0051603,proteolysis involved in cellular protein catabolic process;GO:0051493,regulation of cytoskeleton organization;GO:0032675,regulation of interleukin-6 production;GO:0042542,response to hydrogen peroxide;GO:0001666,response to hypoxia	hsa:824,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:824,path:hsa04210,Apoptosis;hsa:824,path:hsa04217,Necroptosis;hsa:824,path:hsa04218,Cellular senescence;hsa:824,path:hsa04510,Focal adhesion;hsa:824,path:hsa05010,Alzheimer disease;hsa:824,path:hsa05131,Shigellosis
COPG1_HUMAN	Q9Y678	COPG1	Coatomer subunit gamma-1	7.962747076	8.979147341	12.30804476	6.078054807	8.4709472085	9.1930497835	8.4709472085	9.1930497835	0.921451249367098	0.460610	0	1.08524460809712	0.460472	0	GO:0030126,COPI vesicle coat;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0030133,transport vesicle	GO:0005198,structural molecule activity	GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0051683,establishment of Golgi localization;GO:0006891,intra-Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0072384,organelle transport along microtubule;GO:0009306,protein secretion;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0016192,vesicle-mediated transport	
ML12B_HUMAN	O14950	MYL12B	Myosin regulatory light chain 12B	25.83065291	38.54021311	3.222160446	4.565927255	32.18543301	3.8940438505	32.18543301	3.8940438505	8.26529804122965	0.025706	1	0.120987772614093	0.025439	-1	GO:0099738,cell cortex region;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016459,myosin complex	GO:0005509,calcium ion binding	GO:0006936,muscle contraction	hsa:103910,path:hsa04510,Focal adhesion;hsa:103910,path:hsa04530,Tight junction;hsa:103910,path:hsa04810,Regulation of actin cytoskeleton;hsa:103910,path:hsa04611,Platelet activation;hsa:103910,path:hsa04670,Leukocyte transendothelial migration;hsa:103910,path:hsa04360,Axon guidance;hsa:103910,path:hsa05132,Salmonella infection;hsa:103910,path:hsa05131,Shigellosis
HV374_HUMAN	A0A0B4J1X5	IGHV3-74	Immunoglobulin heavy variable 3-74	9.055144166	4.519760625	8.059144685	13.8595307	6.7874523955	10.9593376925	6.7874523955	10.9593376925	0.619330527623488	0.334376	0	1.61464671188941	0.334637	0	GO:0009897,external side of plasma membrane;GO:0042571,immunoglobulin complex, circulating;GO:0072562,blood microparticle;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005886,plasma membrane;GO:0019814,immunoglobulin complex	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0006956,complement activation;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955,immune response;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response;GO:0002250,adaptive immune response	
HBB_HUMAN	P68871	HBB	Hemoglobin subunit beta	442.1517025	3481.1288	813.5048653	6985.803185	1961.64025125	3899.65402515	1961.64025125	3899.65402515	0.50302930429182	0.227919	0	1.98795575420369	0.228247	0	GO:0072562,blood microparticle;GO:0005829,cytosol;GO:0071682,endocytic vesicle lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0031838,haptoglobin-hemoglobin complex;GO:0005833,hemoglobin complex;GO:1904724,tertiary granule lumen	GO:0020037,heme binding;GO:0031721,hemoglobin alpha binding;GO:0030492,hemoglobin binding;GO:0046872,metal ion binding;GO:0043177,organic acid binding;GO:0019825,oxygen binding;GO:0005344,oxygen carrier activity	GO:0015701,bicarbonate transport;GO:0007596,blood coagulation;GO:0098869,cellular oxidant detoxification;GO:0042744,hydrogen peroxide catabolic process;GO:0043312,neutrophil degranulation;GO:0030185,nitric oxide transport;GO:0015671,oxygen transport;GO:0070527,platelet aggregation;GO:0010942,positive regulation of cell death;GO:0045429,positive regulation of nitric oxide biosynthetic process;GO:0006898,receptor-mediated endocytosis;GO:0008217,regulation of blood pressure;GO:0070293,renal absorption;GO:0042542,response to hydrogen peroxide	hsa:3043,path:hsa05144,Malaria;hsa:3043,path:hsa05143,African trypanosomiasis
B2MG_HUMAN	P61769	B2M	Beta-2-microglobulin	8.597467786	2.916845674	4.711387222	5.770271837	5.75715673	5.2408295295	5.75715673	5.2408295295	1.09852012884481	0.402436	0	0.910315590713474	0.402174	0	GO:0005829,cytosol;GO:0031905,early endosome lumen;GO:0031901,early endosome membrane;GO:0005788,endoplasmic reticulum lumen;GO:0012507,ER to Golgi transport vesicle membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:1990712,HFE-transferrin receptor complex;GO:0016020,membrane;GO:0042824,MHC class I peptide loading complex;GO:0042612,MHC class I protein complex;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen	GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity	GO:1990000,amyloid fibril formation;GO:0019731,antibacterial humoral response;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0002481,antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0061844,antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0071281,cellular response to iron ion;GO:0071283,cellular response to iron(III) ion;GO:0071222,cellular response to lipopolysaccharide;GO:0071316,cellular response to nicotine;GO:0050829,defense response to Gram-negative bacterium;GO:0050830,defense response to Gram-positive bacterium;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0055072,iron ion homeostasis;GO:0006826,iron ion transport;GO:0007611,learning or memory;GO:0052031,modulation by symbiont of host defense response;GO:0090647,modulation of age-related behavioral decline;GO:0050680,negative regulation of epithelial cell proliferation;GO:2000978,negative regulation of forebrain neuron differentiation;GO:0050768,negative regulation of neurogenesis;GO:0010977,negative regulation of neuron projection development;GO:1900121,negative regulation of receptor binding;GO:0043312,neutrophil degranulation;GO:2000774,positive regulation of cellular senescence;GO:1904434,positive regulation of ferrous iron binding;GO:0032092,positive regulation of protein binding;GO:1900122,positive regulation of receptor binding;GO:0048260,positive regulation of receptor-mediated endocytosis;GO:0002726,positive regulation of T cell cytokine production;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:1904437,positive regulation of transferrin receptor binding;GO:0051289,protein homotetramerization;GO:0042026,protein refolding;GO:0050690,regulation of defense response to virus by virus;GO:0045646,regulation of erythrocyte differentiation;GO:0050776,regulation of immune response;GO:0034756,regulation of iron ion transport;GO:0003254,regulation of membrane depolarization;GO:0046686,response to cadmium ion;GO:0042493,response to drug;GO:0002237,response to molecule of bacterial origin;GO:0001895,retina homeostasis;GO:0033077,T cell differentiation in thymus;GO:0006955,immune response	hsa:567,path:hsa04612,Antigen processing and presentation;hsa:567,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:567,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:567,path:hsa05168,Herpes simplex virus 1 infection;hsa:567,path:hsa05163,Human cytomegalovirus infection;hsa:567,path:hsa05169,Epstein-Barr virus infection
MIRO2_HUMAN	Q8IXI1	RHOT2	Mitochondrial Rho GTPase 2	0.042668329	0.010883058	0.059895709	2.55E-05	0.0267756935	0.0299606045	0.0267756935	0.0299606045	0.893696704283787	0.470855	0	1.11894784349843	0.470740	0	GO:0005829,cytosol;GO:0031307,integral component of mitochondrial outer membrane;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion	GO:0005509,calcium ion binding;GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0019725,cellular homeostasis;GO:0097345,mitochondrial outer membrane permeabilization;GO:0007005,mitochondrion organization;GO:0047497,mitochondrion transport along microtubule;GO:0010821,regulation of mitochondrion organization;GO:0051056,regulation of small GTPase mediated signal transduction	hsa:89941,path:hsa04137,Mitophagy - animal
IGHA2_HUMAN	P01877	IGHA2	Immunoglobulin heavy constant alpha 2	0.741138122	0.461070711	1.705719432	1.22917406	0.6011044165	1.467446746	0.6011044165	1.467446746	0.409626051601875	0.144659	0	2.44125098022799	0.144988	0	GO:0072562,blood microparticle;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0042571,immunoglobulin complex, circulating;GO:0071748,monomeric IgA immunoglobulin complex;GO:0071752,secretory dimeric IgA immunoglobulin complex;GO:0071751,secretory IgA immunoglobulin complex	GO:0003823,antigen binding	GO:0019731,antibacterial humoral response;GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0003094,glomerular filtration;GO:0006955,immune response;GO:0045087,innate immune response;GO:0050900,leukocyte migration;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation;GO:0060267,positive regulation of respiratory burst;GO:0006898,receptor-mediated endocytosis;GO:0001895,retina homeostasis	
AKAP2_HUMAN	Q9Y2D5	AKAP2	A-kinase anchor protein 2	0.036809151	0.035159773	0.132608484	0.284927083	0.035984462	0.2087677835	0.035984462	0.2087677835	0.172365972357991	0.008598	-1	5.80160913618772	0.008668	1				
COG5_HUMAN	Q9UP83	COG5	Conserved oligomeric Golgi complex subunit 5	0.442158631	0.373054852	0.383749473	0.109151232	0.4076067415	0.2464503525	0.4076067415	0.2464503525	1.65391015823359	0.276949	0	0.604627763498362	0.276465	0	GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0017119,Golgi transport complex;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0032588,trans-Golgi network membrane		GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048219,inter-Golgi cisterna vesicle-mediated transport;GO:0006891,intra-Golgi vesicle-mediated transport;GO:0015031,protein transport	
RL23_HUMAN	P62829	RPL23	60S ribosomal protein L23	2.608276419	1.801917961	0.623928511	0.434479146	2.20509719	0.5292038285	2.20509719	0.5292038285	4.16682017635857	0.085227	0	0.2399911581675	0.084732	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0014069,postsynaptic density;GO:0032991,protein-containing complex;GO:0005840,ribosome	GO:0070180,large ribosomal subunit rRNA binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome;GO:0001223,transcription coactivator binding;GO:1990948,ubiquitin ligase inhibitor activity;GO:0031625,ubiquitin protein ligase binding	GO:0072717,cellular response to actinomycin D;GO:0002181,cytoplasmic translation;GO:0071157,negative regulation of cell cycle arrest;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:1904667,negative regulation of ubiquitin protein ligase activity;GO:2000059,negative regulation of ubiquitin-dependent protein catabolic process;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0071158,positive regulation of cell cycle arrest;GO:0008284,positive regulation of cell population proliferation;GO:0010628,positive regulation of gene expression;GO:1901798,positive regulation of signal transduction by p53 class mediator;GO:0050821,protein stabilization;GO:0032986,protein-DNA complex disassembly;GO:0006610,ribosomal protein import into nucleus;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:9349,path:hsa03010,Ribosome
PODN_HUMAN	Q7Z5L7	PODN	Podocan	0.194804217	0.120317847	0.243842728	1.134085065	0.157561032	0.6889638965	0.157561032	0.6889638965	0.228692726571631	0.025566	-1	4.3726795118986	0.025714	1	GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005615,extracellular space	GO:0005518,collagen binding	GO:0030336,negative regulation of cell migration;GO:0008285,negative regulation of cell population proliferation	
ICT1_HUMAN	Q14197	MRPL58	Peptidyl-tRNA hydrolase ICT1, mitochondrial	0.167566202	0.408364097	0.015567356	0.007218146	0.2879651495	0.011392751	0.2879651495	0.011392751	25.2761733755087	0.001925	1	0.0395629506549021	0.001885	-1	GO:0005743,mitochondrial inner membrane;GO:0005762,mitochondrial large ribosomal subunit;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0004045,aminoacyl-tRNA hydrolase activity;GO:0016150,translation release factor activity, codon nonspecific;GO:0003747,translation release factor activity	GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination	
3MG_HUMAN	P29372	MPG	DNA-3-methyladenine glycosylase	0.090738383	2.55E-05	0.061865563	0.0355846	0.0453819415	0.0487250815	0.0453819415	0.0487250815	0.931387698140638	0.457022	0	1.07366674693722	0.456877	0	GO:0005829,cytosol;GO:0042645,mitochondrial nucleoid;GO:0005654,nucleoplasm;GO:0016021,integral component of membrane	GO:0003905,alkylbase DNA N-glycosylase activity;GO:0003684,damaged DNA binding;GO:0008725,DNA-3-methyladenine glycosylase activity;GO:0052822,DNA-3-methylguanine glycosylase activity;GO:0052821,DNA-7-methyladenine glycosylase activity;GO:0043916,DNA-7-methylguanine glycosylase activity;GO:0003677,DNA binding	GO:0006284,base-excision repair;GO:0006287,base-excision repair, gap-filling;GO:0045007,depurination;GO:0006307,DNA dealkylation involved in DNA repair	hsa:4350,path:hsa03410,Base excision repair
DOCK7_HUMAN	Q96N67	DOCK7	Dedicator of cytokinesis protein 7	0.16092302	0.112171719	0.111235692	0.569347871	0.1365473695	0.3402917815	0.1365473695	0.3402917815	0.401265551868757	0.137607	0	2.49211524722928	0.137933	0	GO:0030424,axon;GO:0045178,basal part of cell;GO:0005925,focal adhesion;GO:0030426,growth cone;GO:0043005,neuron projection	GO:0005085,guanyl-nucleotide exchange factor activity;GO:0031267,small GTPase binding	GO:0090630,activation of GTPase activity;GO:0007409,axonogenesis;GO:0045200,establishment of neuroblast polarity;GO:0022027,interkinetic nuclear migration;GO:0000226,microtubule cytoskeleton organization;GO:0120163,negative regulation of cold-induced thermogenesis;GO:0031175,neuron projection development;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:1904754,positive regulation of vascular associated smooth muscle cell migration;GO:0050767,regulation of neurogenesis;GO:0007264,small GTPase mediated signal transduction	
MX2_HUMAN	P20592	MX2	Interferon-induced GTP-binding protein Mx2	0.36702078	1.062289351	0.493816347	0.447171877	0.7146550655	0.470494112	0.7146550655	0.470494112	1.51894582157917	0.301469	0	0.658351328792198	0.301021	0	GO:0030424,axon;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0044327,dendritic spine head;GO:0016020,membrane;GO:0015630,microtubule cytoskeleton;GO:0031966,mitochondrial membrane;GO:0005643,nuclear pore;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0098844,postsynaptic endocytic zone membrane;GO:0098793,presynapse	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0008017,microtubule binding	GO:0006952,defense response;GO:0051607,defense response to virus;GO:0003374,dynamin family protein polymerization involved in mitochondrial fission;GO:0061025,membrane fusion;GO:0000266,mitochondrial fission;GO:0051028,mRNA transport;GO:0098884,postsynaptic neurotransmitter receptor internalization;GO:0031623,receptor internalization;GO:0051726,regulation of cell cycle;GO:0046822,regulation of nucleocytoplasmic transport;GO:0050803,regulation of synapse structure or activity;GO:0035455,response to interferon-alpha;GO:0009615,response to virus;GO:0016185,synaptic vesicle budding from presynaptic endocytic zone membrane;GO:0060337,type I interferon signaling pathway	
PMM2_HUMAN	O15305	PMM2	Phosphomannomutase 2	0.921255463	0.836839986	0.841789825	2.143993662	0.8790477245	1.4928917435	0.8790477245	1.4928917435	0.588822148911563	0.306758	0	1.69830567998928	0.307042	0	GO:0005829,cytosol;GO:0043025,neuronal cell body;GO:0005654,nucleoplasm;GO:0005737,cytoplasm	GO:0046872,metal ion binding;GO:0004615,phosphomannomutase activity	GO:0009298,GDP-mannose biosynthetic process;GO:0006013,mannose metabolic process;GO:0006486,protein glycosylation;GO:0006487,protein N-linked glycosylation	hsa:5373,path:hsa00051,Fructose and mannose metabolism;hsa:5373,path:hsa00520,Amino sugar and nucleotide sugar metabolism
TOR1B_HUMAN	O14657	TOR1B	Torsin-1B	0.055047404	0.20043837	0.106270603	2.55E-05	0.127742887	0.0531480515	0.127742887	0.0531480515	2.40352907387395	0.182207	0	0.416054879830609	0.181639	0	GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005635,nuclear envelope;GO:0031965,nuclear membrane	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0042802,identical protein binding;GO:0019894,kinesin binding	GO:0051085,chaperone cofactor-dependent protein refolding;GO:0007029,endoplasmic reticulum organization;GO:0071763,nuclear membrane organization;GO:0034504,protein localization to nucleus;GO:0006986,response to unfolded protein	
K2C75_HUMAN	O95678	KRT75	Keratin, type II cytoskeletal 75	0.027010528	0.218365269	2.55E-05	0.07192215	0.1226878985	0.035973825	0.1226878985	0.035973825	3.41047688145478	0.114698	0	0.293214126575002	0.114154	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005882,intermediate filament;GO:0045095,keratin filament	GO:0005198,structural molecule activity	GO:0070268,cornification;GO:0002244,hematopoietic progenitor cell differentiation;GO:0031424,keratinization	
SPTA1_HUMAN	P02549	SPTA1	Spectrin alpha chain, erythrocytic 1	5.771244334	1.973546061	4.601896561	47.07218925	3.8723951975	25.8370429055	3.8723951975	25.8370429055	0.149877647053629	0.004714	-1	6.672109014643	0.004758	1	GO:0015629,actin cytoskeleton;GO:0030424,axon;GO:0032437,cuticular plate;GO:0005829,cytosol;GO:0031235,intrinsic component of the cytoplasmic side of the plasma membrane;GO:0008091,spectrin;GO:0014731,spectrin-associated cytoskeleton	GO:0051015,actin filament binding;GO:0005509,calcium ion binding;GO:0005200,structural constituent of cytoskeleton	GO:0051693,actin filament capping;GO:0007015,actin filament organization;GO:0007411,axon guidance;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0030097,hemopoiesis;GO:0002260,lymphocyte homeostasis;GO:0000165,MAPK cascade;GO:0007009,plasma membrane organization;GO:0006779,porphyrin-containing compound biosynthetic process;GO:0032092,positive regulation of protein binding;GO:0042102,positive regulation of T cell proliferation;GO:0008360,regulation of cell shape	hsa:6708,path:hsa04210,Apoptosis
MNDA_HUMAN	P41218	MNDA	Myeloid cell nuclear differentiation antigen	0.804688249	12.34003434	0.432355418	0.410277137	6.5723612945	0.4213162775	6.5723612945	0.4213162775	15.5995902496314	0.006507	1	0.0641042478678969	0.006404	-1	GO:0035578,azurophil granule lumen;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0043231,intracellular membrane-bounded organelle;GO:0005730,nucleolus;GO:0005654,nucleoplasm	GO:0003690,double-stranded DNA binding	GO:0002218,activation of innate immune response;GO:0050853,B cell receptor signaling pathway;GO:0006968,cellular defense response;GO:0006974,cellular response to DNA damage stimulus;GO:0035458,cellular response to interferon-beta;GO:0030889,negative regulation of B cell proliferation;GO:0043312,neutrophil degranulation;GO:0043065,positive regulation of apoptotic process;GO:0032731,positive regulation of interleukin-1 beta production	
DHB12_HUMAN	Q53GQ0	HSD17B12	Very-long-chain 3-oxoacyl-CoA reductase	3.484128562	4.039287204	5.004064322	3.694295943	3.761707883	4.3491801325	3.761707883	4.3491801325	0.864923449569262	0.481840	0	1.15617168258995	0.481749	0	GO:0005789,endoplasmic reticulum membrane;GO:0031012,extracellular matrix;GO:0009923,fatty acid elongase complex;GO:0016021,integral component of membrane	GO:0044594,17-beta-hydroxysteroid dehydrogenase (NAD+) activity;GO:0072582,17-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:0102339,3-oxo-arachidoyl-CoA reductase activity;GO:0102340,3-oxo-behenoyl-CoA reductase activity;GO:0102342,3-oxo-cerotoyl-CoA reductase activity;GO:0102341,3-oxo-lignoceroyl-CoA reductase activity;GO:0005518,collagen binding;GO:0001968,fibronectin binding;GO:0008201,heparin binding;GO:0050062,long-chain-fatty-acyl-CoA reductase activity;GO:0016491,oxidoreductase activity	GO:0006703,estrogen biosynthetic process;GO:0030198,extracellular matrix organization;GO:0006633,fatty acid biosynthetic process;GO:0035338,long-chain fatty-acyl-CoA biosynthetic process;GO:0010811,positive regulation of cell-substrate adhesion	hsa:51144,path:hsa00062,Fatty acid elongation;hsa:51144,path:hsa00140,Steroid hormone biosynthesis;hsa:51144,path:hsa01040,Biosynthesis of unsaturated fatty acids
FUBP3_HUMAN	Q96I24	FUBP3	Far upstream element-binding protein 3	1.673657295	2.750208222	1.347184458	1.185432346	2.2119327585	1.266308402	2.2119327585	1.266308402	1.74675675767964	0.261748	0	0.572489555631309	0.261244	0	GO:0005737,cytoplasm;GO:0016020,membrane;GO:0005634,nucleus	GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0003697,single-stranded DNA binding	GO:0010628,positive regulation of gene expression;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0010468,regulation of gene expression;GO:0006351,transcription, DNA-templated	
KS6A3_HUMAN	P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	1.373696758	1.586902523	2.397052118	3.405446429	1.4802996405	2.9012492735	1.4802996405	2.9012492735	0.510228353703024	0.234532	0	1.95990676085015	0.234858	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0045202,synapse;GO:0005840,ribosome	GO:0005524,ATP binding;GO:0043027,cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0000287,magnesium ion binding;GO:0004672,protein kinase activity;GO:0019901,protein kinase binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0004711,ribosomal protein S6 kinase activity	GO:0007049,cell cycle;GO:0007417,central nervous system development;GO:0007268,chemical synaptic transmission;GO:0035556,intracellular signal transduction;GO:0043066,negative regulation of apoptotic process;GO:0043154,negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0018105,peptidyl-serine phosphorylation;GO:0045597,positive regulation of cell differentiation;GO:0030307,positive regulation of cell growth;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0043620,regulation of DNA-templated transcription in response to stress;GO:0043555,regulation of translation in response to stress;GO:0032496,response to lipopolysaccharide;GO:0007165,signal transduction;GO:0001501,skeletal system development;GO:0002224,toll-like receptor signaling pathway	hsa:6197,path:hsa04010,MAPK signaling pathway;hsa:6197,path:hsa04150,mTOR signaling pathway;hsa:6197,path:hsa04114,Oocyte meiosis;hsa:6197,path:hsa04914,Progesterone-mediated oocyte maturation;hsa:6197,path:hsa04720,Long-term potentiation;hsa:6197,path:hsa04722,Neurotrophin signaling pathway;hsa:6197,path:hsa04714,Thermogenesis;hsa:6197,path:hsa04931,Insulin resistance;hsa:6197,path:hsa05135,Yersinia infection
NDUV1_HUMAN	P49821	NDUFV1	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	3.218526843	1.642705064	3.591916042	2.122465306	2.4306159535	2.857190674	2.4306159535	2.857190674	0.850701346472336	0.487410	0	1.17550066676957	0.487332	0	GO:0005829,cytosol;GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I;GO:0005739,mitochondrion;GO:0070469,respirasome	GO:0051539,4 iron, 4 sulfur cluster binding;GO:0010181,FMN binding;GO:0046872,metal ion binding;GO:0051287,NAD binding;GO:0008137,NADH dehydrogenase (ubiquinone) activity	GO:0042775,mitochondrial ATP synthesis coupled electron transport;GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly	hsa:4723,path:hsa00190,Oxidative phosphorylation;hsa:4723,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4723,path:hsa04714,Thermogenesis;hsa:4723,path:hsa05010,Alzheimer disease;hsa:4723,path:hsa05012,Parkinson disease;hsa:4723,path:hsa05016,Huntington disease;hsa:4723,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
DEOC_HUMAN	Q9Y315	DERA	Deoxyribose-phosphate aldolase	0.351831934	0.392778991	0.55045148	1.307288946	0.3723054625	0.928870213	0.3723054625	0.928870213	0.400815374730937	0.137230	0	2.49491427486106	0.137556	0	GO:0005829,cytosol;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005654,nucleoplasm;GO:0034774,secretory granule lumen;GO:0005737,cytoplasm	GO:0004139,deoxyribose-phosphate aldolase activity	GO:0016052,carbohydrate catabolic process;GO:0046121,deoxyribonucleoside catabolic process;GO:0009264,deoxyribonucleotide catabolic process;GO:0046386,deoxyribose phosphate catabolic process;GO:0043312,neutrophil degranulation;GO:0006098,pentose-phosphate shunt	hsa:51071,path:hsa00030,Pentose phosphate pathway
NT5C_HUMAN	Q8TCD5	NT5C	5'(3')-deoxyribonucleotidase, cytosolic type	0.023106119	0.05777581	0.13261293	2.55E-05	0.0404409645	0.066319215	0.0404409645	0.066319215	0.609792569167171	0.325785	0	1.63990191183497	0.326054	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0008253,5'-nucleotidase activity;GO:0042802,identical protein binding;GO:0050483,IMP 5'-nucleotidase activity;GO:0046872,metal ion binding;GO:0008252,nucleotidase activity;GO:0019103,pyrimidine nucleotide binding	GO:0006249,dCMP catabolic process;GO:0016311,dephosphorylation;GO:0046055,dGMP catabolic process;GO:0046074,dTMP catabolic process;GO:0046079,dUMP catabolic process;GO:0006204,IMP catabolic process;GO:0006195,purine nucleotide catabolic process;GO:0009223,pyrimidine deoxyribonucleotide catabolic process;GO:0046135,pyrimidine nucleoside catabolic process;GO:0046050,UMP catabolic process;GO:0009264,deoxyribonucleotide catabolic process	hsa:30833,path:hsa00230,Purine metabolism;hsa:30833,path:hsa00240,Pyrimidine metabolism;hsa:30833,path:hsa00760,Nicotinate and nicotinamide metabolism
LEG9_HUMAN	O00182	LGALS9	Galectin-9	1.009529718	5.913623138	1.048757818	0.68675393	3.461576428	0.867755874	3.461576428	0.867755874	3.98911321918634	0.091101	0	0.250682280761128	0.090593	0	GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005615,extracellular space;GO:0005634,nucleus	GO:0030246,carbohydrate binding;GO:0048030,disaccharide binding;GO:0019899,enzyme binding;GO:0005534,galactose binding;GO:0016936,galactoside binding	GO:0071346,cellular response to interferon-gamma;GO:0098586,cellular response to virus;GO:0006935,chemotaxis;GO:0070371,ERK1 and ERK2 cascade;GO:0007565,female pregnancy;GO:0006954,inflammatory response;GO:0060135,maternal process involved in female pregnancy;GO:0002519,natural killer cell tolerance induction;GO:0046007,negative regulation of activated T cell proliferation;GO:2000562,negative regulation of CD4-positive, alpha-beta T cell proliferation;GO:0032682,negative regulation of chemokine production;GO:0010629,negative regulation of gene expression;GO:0032689,negative regulation of interferon-gamma production;GO:0043305,negative regulation of mast cell degranulation;GO:0045953,negative regulation of natural killer cell mediated cytotoxicity;GO:0032720,negative regulation of tumor necrosis factor production;GO:0038066,p38MAPK cascade;GO:0070241,positive regulation of activated T cell autonomous cell death;GO:2000563,positive regulation of CD4-positive, alpha-beta T cell proliferation;GO:0032834,positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response;GO:2001269,positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:2000670,positive regulation of dendritic cell apoptotic process;GO:2000510,positive regulation of dendritic cell chemotaxis;GO:2001200,positive regulation of dendritic cell differentiation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0010628,positive regulation of gene expression;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0032729,positive regulation of interferon-gamma production;GO:0032731,positive regulation of interleukin-1 beta production;GO:0032733,positive regulation of interleukin-10 production;GO:0032735,positive regulation of interleukin-12 production;GO:0032736,positive regulation of interleukin-13 production;GO:0032753,positive regulation of interleukin-4 production;GO:0032755,positive regulation of interleukin-6 production;GO:0032757,positive regulation of interleukin-8 production;GO:0071639,positive regulation of monocyte chemotactic protein-1 production;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:2001190,positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0071636,positive regulation of transforming growth factor beta production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0046598,positive regulation of viral entry into host cell;GO:0070555,response to interleukin-1;GO:0032496,response to lipopolysaccharide	
RALB_HUMAN	P11234	RALB	Ras-related protein Ral-B	0.013409363	0.062918809	0.234655206	0.195204421	0.038164086	0.2149298135	0.038164086	0.2149298135	0.177565342743853	0.009718	-1	5.63172961878348	0.009794	1	GO:0070062,extracellular exosome;GO:0030496,midbody;GO:0005886,plasma membrane	GO:0051117,ATPase binding;GO:0003925,G protein activity;GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0031625,ubiquitin protein ligase binding	GO:0006915,apoptotic process;GO:0007049,cell cycle;GO:0051301,cell division;GO:0071360,cellular response to exogenous dsRNA;GO:0009267,cellular response to starvation;GO:0032091,negative regulation of protein binding;GO:2000786,positive regulation of autophagosome assembly;GO:0032092,positive regulation of protein binding;GO:0001934,positive regulation of protein phosphorylation;GO:0071902,positive regulation of protein serine/threonine kinase activity;GO:0007265,Ras protein signal transduction;GO:0001928,regulation of exocyst assembly;GO:0060178,regulation of exocyst localization;GO:0007165,signal transduction	hsa:5899,path:hsa04014,Ras signaling pathway;hsa:5899,path:hsa04015,Rap1 signaling pathway;hsa:5899,path:hsa04072,Phospholipase D signaling pathway;hsa:5899,path:hsa05200,Pathways in cancer;hsa:5899,path:hsa05210,Colorectal cancer;hsa:5899,path:hsa05212,Pancreatic cancer
ARFG1_HUMAN	Q8N6T3	ARFGAP1	ADP-ribosylation factor GTPase-activating protein 1	0.121747921	0.130977779	0.140430178	0.087610482	0.12636285	0.11402033	0.12636285	0.11402033	1.10824841499757	0.399563	0	0.902324773459921	0.399295	0	GO:0005829,cytosol;GO:0000139,Golgi membrane;GO:0045202,synapse	GO:0005096,GTPase activator activity;GO:0046872,metal ion binding	GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0036498,IRE1-mediated unfolded protein response;GO:0015031,protein transport;GO:0032012,regulation of ARF protein signal transduction;GO:0030100,regulation of endocytosis;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0043547,positive regulation of GTPase activity	hsa:55738,path:hsa04144,Endocytosis
PUR2_HUMAN	P22102	GART	Trifunctional purine biosynthetic protein adenosine-3	1.571904472	1.050109043	2.163065197	1.679742879	1.3110067575	1.921404038	1.3110067575	1.921404038	0.682317061675708	0.389798	0	1.46559430529861	0.390008	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0005524,ATP binding;GO:0046872,metal ion binding;GO:0004637,phosphoribosylamine-glycine ligase activity;GO:0004641,phosphoribosylformylglycinamidine cyclo-ligase activity;GO:0004644,phosphoribosylglycinamide formyltransferase activity	GO:0006189,'de novo' IMP biosynthetic process;GO:0046084,adenine biosynthetic process;GO:0003360,brainstem development;GO:0021549,cerebellum development;GO:0021987,cerebral cortex development;GO:0006544,glycine metabolic process;GO:0006164,purine nucleotide biosynthetic process;GO:0009168,purine ribonucleoside monophosphate biosynthetic process;GO:0010035,response to inorganic substance;GO:0010033,response to organic substance;GO:0046654,tetrahydrofolate biosynthetic process;GO:0009113,purine nucleobase biosynthetic process	hsa:2618,path:hsa00230,Purine metabolism;hsa:2618,path:hsa00670,One carbon pool by folate;hsa:2618,path:hsa01523,Antifolate resistance
MOV10_HUMAN	Q9HCE1	MOV10	Helicase MOV-10	0.269336902	0.185565884	0.37683805	0.347175978	0.227451393	0.362007014	0.227451393	0.362007014	0.62830659131925	0.342418	0	1.59157967434387	0.342673	0	GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0005615,extracellular space;GO:0005634,nucleus;GO:0043186,P granule;GO:0000932,P-body	GO:0032574,5'-3' RNA helicase activity;GO:0005524,ATP binding;GO:0003723,RNA binding	GO:0061158,3'-UTR-mediated mRNA destabilization;GO:0051607,defense response to virus;GO:0035195,gene silencing by miRNA;GO:0030522,intracellular receptor signaling pathway;GO:0035279,mRNA cleavage involved in gene silencing by miRNA;GO:0010629,negative regulation of gene expression;GO:0010526,negative regulation of transposition, RNA-mediated;GO:0010628,positive regulation of gene expression;GO:0061014,positive regulation of mRNA catabolic process;GO:0035194,post-transcriptional gene silencing by RNA;GO:0045652,regulation of megakaryocyte differentiation;GO:0150011,regulation of neuron projection arborization;GO:0060260,regulation of transcription initiation from RNA polymerase II promoter;GO:0016032,viral process;GO:0007223,Wnt signaling pathway, calcium modulating pathway	
HSP72_HUMAN	P54652	HSPA2	Heat shock-related 70 kDa protein 2	0.196877301	0.014776732	2.55E-05	0.381118863	0.1058270165	0.1905721815	0.1058270165	0.1905721815	0.555311985553358	0.276054	0	1.80078951295013	0.276358	0	GO:0072562,blood microparticle;GO:0036128,CatSper complex;GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0001673,male germ cell nucleus;GO:0072687,meiotic spindle;GO:0016020,membrane;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0000795,synaptonemal complex	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0051087,chaperone binding;GO:0097718,disordered domain specific binding;GO:0019899,enzyme binding;GO:0051861,glycolipid binding;GO:0031072,heat shock protein binding;GO:0051787,misfolded protein binding;GO:0044183,protein folding chaperone;GO:0048156,tau protein binding;GO:0051082,unfolded protein binding	GO:0034620,cellular response to unfolded protein;GO:0051085,chaperone cofactor-dependent protein refolding;GO:0007141,male meiosis I;GO:0007140,male meiotic nuclear division;GO:0090084,negative regulation of inclusion body assembly;GO:1901896,positive regulation of ATPase-coupled calcium transmembrane transporter activity;GO:0010971,positive regulation of G2/M transition of mitotic cell cycle;GO:0001934,positive regulation of protein phosphorylation;GO:0042026,protein refolding;GO:0009409,response to cold;GO:0009408,response to heat;GO:0006986,response to unfolded protein;GO:0007286,spermatid development;GO:0007283,spermatogenesis;GO:0070194,synaptonemal complex disassembly;GO:0016192,vesicle-mediated transport	hsa:3306,path:hsa03040,Spliceosome;hsa:3306,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:3306,path:hsa04010,MAPK signaling pathway;hsa:3306,path:hsa04144,Endocytosis;hsa:3306,path:hsa04612,Antigen processing and presentation;hsa:3306,path:hsa04915,Estrogen signaling pathway;hsa:3306,path:hsa04213,Longevity regulating pathway - multiple species;hsa:3306,path:hsa05134,Legionellosis;hsa:3306,path:hsa05162,Measles;hsa:3306,path:hsa05145,Toxoplasmosis
AN32E_HUMAN	Q9BTT0	ANP32E	Acidic leucine-rich nuclear phosphoprotein 32 family member E	0.852815138	1.985121075	0.094581849	0.112565275	1.4189681065	0.103573562	1.4189681065	0.103573562	13.7000995147777	0.008799	1	0.0729921705255748	0.008671	-1	GO:0031410,cytoplasmic vesicle;GO:0005634,nucleus;GO:0000812,Swr1 complex	GO:0042393,histone binding;GO:0019212,phosphatase inhibitor activity	GO:0043486,histone exchange;GO:0042981,regulation of apoptotic process	
SPRY4_HUMAN	Q8WW59	SPRYD4	SPRY domain-containing protein 4	1.140547361	3.285942628	0.165031972	0.03189041	2.2132449945	0.098461191	2.2132449945	0.098461191	22.4783487993762	0.002625	1	0.0444872534421991	0.002574	-1	GO:0005634,nucleus			
AQR_HUMAN	O60306	AQR	RNA helicase aquarius	0.230255644	0.252507052	0.563982185	0.330626122	0.241381348	0.4473041535	0.241381348	0.4473041535	0.539635829695018	0.261618	0	1.8531015640032	0.261930	0	GO:0071013,catalytic step 2 spliceosome;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0071007,U2-type catalytic step 2 spliceosome;GO:0005681,spliceosomal complex	GO:0034458,3'-5' RNA helicase activity;GO:0005524,ATP binding;GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:0003727,single-stranded RNA binding	GO:0000398,mRNA splicing, via spliceosome;GO:0006283,transcription-coupled nucleotide-excision repair	hsa:9716,path:hsa03040,Spliceosome
PI3R4_HUMAN	Q99570	PIK3R4	Phosphoinositide 3-kinase regulatory subunit 4	0.057125471	0.034463358	0.269878545	0.107484441	0.0457944145	0.188681493	0.0457944145	0.188681493	0.242707505499758	0.031480	-1	4.12018572701699	0.031648	1	GO:0005776,autophagosome;GO:0005930,axoneme;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0005770,late endosome;GO:0016020,membrane;GO:0015630,microtubule cytoskeleton;GO:0071561,nucleus-vacuole junction;GO:0030670,phagocytic vesicle membrane;GO:0035032,phosphatidylinositol 3-kinase complex, class III;GO:0034271,phosphatidylinositol 3-kinase complex, class III, type I;GO:0034272,phosphatidylinositol 3-kinase complex, class III, type II	GO:0005524,ATP binding;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity	GO:0030242,autophagy of peroxisome;GO:0042149,cellular response to glucose starvation;GO:0045324,late endosome to vacuole transport;GO:0016236,macroautophagy;GO:0006661,phosphatidylinositol biosynthetic process;GO:0043552,positive regulation of phosphatidylinositol 3-kinase activity;GO:0006468,protein phosphorylation;GO:0006623,protein targeting to vacuole;GO:0032801,receptor catabolic process;GO:0032465,regulation of cytokinesis;GO:0034162,toll-like receptor 9 signaling pathway	hsa:30849,path:hsa04371,Apelin signaling pathway;hsa:30849,path:hsa04140,Autophagy - animal;hsa:30849,path:hsa04136,Autophagy - other;hsa:30849,path:hsa05017,Spinocerebellar ataxia;hsa:30849,path:hsa05131,Shigellosis
CYFP2_HUMAN	Q96F07	CYFIP2	Cytoplasmic FMR1-interacting protein 2	0.116221121	0.04258105	0.185758425	0.021861782	0.0794010855	0.1038101035	0.0794010855	0.1038101035	0.764868570813052	0.458065	0	1.30741415997392	0.458203	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0043005,neuron projection;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0031209,SCAR complex;GO:0045202,synapse	GO:0031267,small GTPase binding	GO:0097202,activation of cysteine-type endopeptidase activity;GO:0006915,apoptotic process;GO:0000902,cell morphogenesis;GO:0098609,cell-cell adhesion;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0045862,positive regulation of proteolysis;GO:0030833,regulation of actin filament polymerization;GO:0048010,vascular endothelial growth factor receptor signaling pathway	hsa:26999,path:hsa03013,RNA transport;hsa:26999,path:hsa04810,Regulation of actin cytoskeleton;hsa:26999,path:hsa05130,Pathogenic Escherichia coli infection;hsa:26999,path:hsa05132,Salmonella infection
UCRI_HUMAN	P47985	UQCRFS1	Cytochrome b-c1 complex subunit Rieske, mitochondrial	3.646179054	9.054216974	0.888692495	0.091300363	6.350198014	0.489996429	6.350198014	0.489996429	12.9596822306638	0.009979	1	0.0771623857901323	0.009838	-1	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005750,mitochondrial respiratory chain complex III;GO:0005751,mitochondrial respiratory chain complex IV;GO:0005739,mitochondrion	GO:0051537,2 iron, 2 sulfur cluster binding;GO:0046872,metal ion binding;GO:0016491,oxidoreductase activity;GO:0008121,ubiquinol-cytochrome-c reductase activity	GO:0006122,mitochondrial electron transport, ubiquinol to cytochrome c;GO:0034551,mitochondrial respiratory chain complex III assembly;GO:0022904,respiratory electron transport chain	hsa:7386,path:hsa00190,Oxidative phosphorylation;hsa:7386,path:hsa04260,Cardiac muscle contraction;hsa:7386,path:hsa04714,Thermogenesis;hsa:7386,path:hsa05010,Alzheimer disease;hsa:7386,path:hsa05012,Parkinson disease;hsa:7386,path:hsa05016,Huntington disease;hsa:7386,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
MYADM_HUMAN	Q96S97	MYADM	Myeloid-associated differentiation marker	1.204378987	1.58944528	1.660184094	2.910809695	1.3969121335	2.2854968945	1.3969121335	2.2854968945	0.611207189500734	0.327062	0	1.63610640905067	0.327330	0	GO:0005911,cell-cell junction;GO:0030864,cortical actin cytoskeleton;GO:0016021,integral component of membrane;GO:0045121,membrane raft;GO:0005886,plasma membrane;GO:0001726,ruffle		GO:0061028,establishment of endothelial barrier;GO:0031579,membrane raft organization;GO:0030837,negative regulation of actin filament polymerization;GO:0010629,negative regulation of gene expression;GO:0034115,negative regulation of heterotypic cell-cell adhesion;GO:0090038,negative regulation of protein kinase C signaling;GO:0001933,negative regulation of protein phosphorylation;GO:0030335,positive regulation of cell migration;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0072659,protein localization to plasma membrane	
NDUS6_HUMAN	O75380	NDUFS6	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	0.088281384	0.086319015	0.106931426	0.100871676	0.0873001995	0.103901551	0.0873001995	0.103901551	0.840220368798922	0.491578	0	1.19016395833093	0.491509	0	GO:0005743,mitochondrial inner membrane;GO:0005747,mitochondrial respiratory chain complex I	GO:0009055,electron transfer activity;GO:0008137,NADH dehydrogenase (ubiquinone) activity	GO:0006120,mitochondrial electron transport, NADH to ubiquinone;GO:0032981,mitochondrial respiratory chain complex I assembly	hsa:4726,path:hsa00190,Oxidative phosphorylation;hsa:4726,path:hsa04723,Retrograde endocannabinoid signaling;hsa:4726,path:hsa04714,Thermogenesis;hsa:4726,path:hsa05010,Alzheimer disease;hsa:4726,path:hsa05012,Parkinson disease;hsa:4726,path:hsa05016,Huntington disease;hsa:4726,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
PSIP1_HUMAN	O75475	PSIP1	PC4 and SFRS1-interacting protein	0.063915003	0.088861322	0.23584912	0.027216316	0.0763881625	0.131532718	0.0763881625	0.131532718	0.580754078996528	0.299394	0	1.72189922751447	0.299683	0	GO:0005829,cytosol;GO:0000792,heterochromatin;GO:0034399,nuclear periphery;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0035327,transcriptionally active chromatin	GO:0033613,activating transcription factor binding;GO:0003682,chromatin binding;GO:0003690,double-stranded DNA binding;GO:0003723,RNA binding;GO:0097100,supercoiled DNA binding;GO:0003713,transcription coactivator activity;GO:0003712,transcription coregulator activity	GO:0075713,establishment of integrated proviral latency;GO:0000395,mRNA 5'-splice site recognition;GO:0051169,nuclear transport;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0006357,regulation of transcription by RNA polymerase II;GO:0009408,response to heat;GO:0006979,response to oxidative stress	
ABCB7_HUMAN	O75027	ABCB7	Iron-sulfur clusters transporter ABCB7, mitochondrial	0.124642915	0.165841614	0.29526704	0.973925003	0.1452422645	0.6345960215	0.1452422645	0.6345960215	0.228873581899694	0.025638	-1	4.36922423155968	0.025786	1	GO:0016021,integral component of membrane;GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion	GO:0005524,ATP binding;GO:0042626,ATPase-coupled transmembrane transporter activity;GO:0015232,heme transmembrane transporter activity	GO:0006879,cellular iron ion homeostasis;GO:0055085,transmembrane transport	hsa:22,path:hsa02010,ABC transporters
PHB2_HUMAN	Q99623	PHB2	Prohibitin-2	14.23936606	22.56465573	14.45329621	8.431775683	18.402010895	11.4425359465	18.402010895	11.4425359465	1.60821088795694	0.284912	0	0.621808997494347	0.284438	0	GO:0030424,axon;GO:0071944,cell periphery;GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0098982,GABA-ergic synapse;GO:0098978,glutamatergic synapse;GO:0005743,mitochondrial inner membrane;GO:0005741,mitochondrial outer membrane;GO:0035632,mitochondrial prohibitin complex;GO:0005739,mitochondrion;GO:0016363,nuclear matrix;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0014069,postsynaptic density;GO:0048786,presynaptic active zone;GO:0032991,protein-containing complex	GO:0033218,amide binding;GO:0030331,estrogen receptor binding;GO:0042802,identical protein binding;GO:0008022,protein C-terminus binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0047485,protein N-terminus binding;GO:0046625,sphingolipid binding	GO:0007202,activation of phospholipase C activity;GO:1990051,activation of protein kinase C activity;GO:0140374,antiviral innate immune response;GO:0042113,B cell activation;GO:0023035,CD40 signaling pathway;GO:0016477,cell migration;GO:0071456,cellular response to hypoxia;GO:0071300,cellular response to retinoic acid;GO:0039520,induction by virus of host autophagy;GO:0060749,mammary gland alveolus development;GO:0060744,mammary gland branching involved in thelarche;GO:0006851,mitochondrial calcium ion transmembrane transport;GO:0007005,mitochondrion organization;GO:0000423,mitophagy;GO:0043066,negative regulation of apoptotic process;GO:0043433,negative regulation of DNA-binding transcription factor activity;GO:0033147,negative regulation of intracellular estrogen receptor signaling pathway;GO:0033600,negative regulation of mammary gland epithelial cell proliferation;GO:0045892,negative regulation of transcription, DNA-templated;GO:1902808,positive regulation of cell cycle G1/S phase transition;GO:0051091,positive regulation of DNA-binding transcription factor activity;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0031536,positive regulation of exit from mitosis;GO:0002639,positive regulation of immunoglobulin production;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:0006606,protein import into nucleus;GO:0050821,protein stabilization;GO:0060762,regulation of branching involved in mammary gland duct morphogenesis;GO:1900208,regulation of cardiolipin metabolic process;GO:1904959,regulation of cytochrome-c oxidase activity;GO:0009611,response to wounding;GO:0039529,RIG-I signaling pathway;GO:0007062,sister chromatid cohesion	
PFD2_HUMAN	Q9UHV9	PFDN2	Prefoldin subunit 2	1.487563239	1.961113309	0.138885171	0.025351133	1.724338274	0.082118152	1.724338274	0.082118152	20.9982596052576	0.003130	1	0.0476229944194813	0.003071	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0016272,prefoldin complex	GO:0001540,amyloid-beta binding;GO:0044183,protein folding chaperone;GO:0051082,unfolded protein binding	GO:1905907,negative regulation of amyloid fibril formation;GO:0051495,positive regulation of cytoskeleton organization;GO:0006457,protein folding	
SNAA_HUMAN	P54920	NAPA	Alpha-soluble NSF attachment protein	1.911362509	2.128388326	2.920497187	3.24342925	2.0198754175	3.0819632185	2.0198754175	3.0819632185	0.655385958331806	0.366406	0	1.52581846969282	0.366639	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0098978,glutamatergic synapse;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0098794,postsynapse;GO:0098793,presynapse;GO:0031201,SNARE complex;GO:0070044,synaptobrevin 2-SNAP-25-syntaxin-1a complex;GO:0005774,vacuolar membrane	GO:0044877,protein-containing complex binding;GO:0000149,SNARE binding;GO:0005483,soluble NSF attachment protein activity;GO:0019905,syntaxin binding	GO:0045176,apical protein localization;GO:0007420,brain development;GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006891,intra-Golgi vesicle-mediated transport;GO:0006886,intracellular protein transport;GO:0061025,membrane fusion;GO:0030182,neuron differentiation;GO:0032781,positive regulation of ATPase activity;GO:0006892,post-Golgi vesicle-mediated transport;GO:0010807,regulation of synaptic vesicle priming;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0035494,SNARE complex disassembly;GO:0035249,synaptic transmission, glutamatergic;GO:0016082,synaptic vesicle priming;GO:0016192,vesicle-mediated transport	hsa:8775,path:hsa04721,Synaptic vesicle cycle
5NTC_HUMAN	P49902	NT5C2	Cytosolic purine 5'-nucleotidase	0.917289601	1.147697872	1.244997734	0.784551666	1.0324937365	1.0147747	1.0324937365	1.0147747	1.01746105465578	0.427619	0	0.982838601462063	0.427410	0	GO:0005829,cytosol	GO:0008253,5'-nucleotidase activity;GO:0050484,GMP 5'-nucleotidase activity;GO:0046872,metal ion binding;GO:0000166,nucleotide binding;GO:0016787,hydrolase activity	GO:0046085,adenosine metabolic process;GO:0017144,drug metabolic process;GO:0046040,IMP metabolic process;GO:0006195,purine nucleotide catabolic process	hsa:22978,path:hsa00230,Purine metabolism;hsa:22978,path:hsa00240,Pyrimidine metabolism;hsa:22978,path:hsa00760,Nicotinate and nicotinamide metabolism
TM9S1_HUMAN	O15321	TM9SF1	Transmembrane 9 superfamily member 1	0.191838843	0.303398155	0.248330261	0.277388738	0.247618499	0.2628594995	0.247618499	0.2628594995	0.942018452713367	0.453230	0	1.06155033069642	0.453077	0	GO:0000421,autophagosome membrane;GO:0031410,cytoplasmic vesicle;GO:0016021,integral component of membrane;GO:0005765,lysosomal membrane;GO:0016020,membrane		GO:0006914,autophagy;GO:0072657,protein localization to membrane	
TMED5_HUMAN	Q9Y3A6	TMED5	Transmembrane emp24 domain-containing protein 5	0.074922852	0.39110015	0.108319867	2.55E-05	0.233011501	0.0541726835	0.233011501	0.0541726835	4.30127300228721	0.081130	0	0.232489311761483	0.080643	0	GO:0005801,cis-Golgi network;GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005783,endoplasmic reticulum;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane		GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030,Golgi organization;GO:0090161,Golgi ribbon formation;GO:0006886,intracellular protein transport;GO:0015031,protein transport	
NU188_HUMAN	Q5SRE5	NUP188	Nucleoporin NUP188	0.153516792	0.06725156	0.118838115	0.120473373	0.110384176	0.119655744	0.110384176	0.119655744	0.922514643342153	0.460224	0	1.08399363329034	0.460085	0	GO:0005829,cytosol;GO:0043657,host cell;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0044611,nuclear pore inner ring	GO:0017056,structural constituent of nuclear pore	GO:0075733,intracellular transport of virus;GO:0007084,mitotic nuclear envelope reassembly;GO:0006406,mRNA export from nucleus;GO:0006606,protein import into nucleus;GO:0016925,protein sumoylation;GO:1900034,regulation of cellular response to heat;GO:0060964,regulation of gene silencing by miRNA;GO:0006110,regulation of glycolytic process;GO:0006405,RNA export from nucleus;GO:0006409,tRNA export from nucleus;GO:0019058,viral life cycle;GO:0016032,viral process;GO:0019083,viral transcription	hsa:23511,path:hsa03013,RNA transport
SNX8_HUMAN	Q9Y5X2	SNX8	Sorting nexin-8	1.444406776	0.872208514	1.529055274	1.265389857	1.158307645	1.3972225655	1.158307645	1.3972225655	0.829007255966766	0.496095	0	1.20626205959298	0.496036	0	GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane	GO:0042802,identical protein binding;GO:0035091,phosphatidylinositol binding	GO:0034498,early endosome to Golgi transport;GO:0006886,intracellular protein transport;GO:0015031,protein transport;GO:0042147,retrograde transport, endosome to Golgi	
SDCB1_HUMAN	O00560	SDCBP	Syntenin-1	0.175573822	0.225437469	0.325237007	0.47167538	0.2005056455	0.3984561935	0.2005056455	0.3984561935	0.503206246435218	0.228082	0	1.98725673038468	0.228409	0	GO:0005912,adherens junction;GO:0035578,azurophil granule lumen;GO:0072562,blood microparticle;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1903561,extracellular vesicle;GO:0005925,focal adhesion;GO:0005895,interleukin-5 receptor complex;GO:0042470,melanosome;GO:0016020,membrane;GO:0045121,membrane raft;GO:0031965,nuclear membrane;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0045202,synapse;GO:0016021,integral component of membrane	GO:0008093,cytoskeletal anchor activity;GO:0005109,frizzled binding;GO:0042802,identical protein binding;GO:0005137,interleukin-5 receptor binding;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding;GO:0046982,protein heterodimerization activity;GO:0047485,protein N-terminus binding;GO:0045545,syndecan binding;GO:0050839,cell adhesion molecule binding;GO:0046875,ephrin receptor binding;GO:0019838,growth factor binding;GO:0042043,neurexin family protein binding;GO:0008022,protein C-terminus binding;GO:0044877,protein-containing complex binding	GO:0030036,actin cytoskeleton organization;GO:0007268,chemical synaptic transmission;GO:0048013,ephrin receptor signaling pathway;GO:0035556,intracellular signal transduction;GO:0032435,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0002091,negative regulation of receptor internalization;GO:0043312,neutrophil degranulation;GO:0030307,positive regulation of cell growth;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0010718,positive regulation of epithelial to mesenchymal transition;GO:1903543,positive regulation of exosomal secretion;GO:1903553,positive regulation of extracellular exosome assembly;GO:0046330,positive regulation of JNK cascade;GO:0010862,positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0042327,positive regulation of phosphorylation;GO:0030511,positive regulation of transforming growth factor beta receptor signaling pathway;GO:0006612,protein targeting to membrane;GO:0007346,regulation of mitotic cell cycle;GO:0060544,regulation of necroptotic process;GO:0006930,substrate-dependent cell migration, cell extension;GO:0099054,presynapse assembly;GO:0007265,Ras protein signal transduction	
KPCB_HUMAN	P05771	PRKCB	Protein kinase C beta type	0.123664698	0.161569398	0.351418007	0.380721256	0.142617048	0.3660696315	0.142617048	0.3660696315	0.389589946086528	0.127924	0	2.56680135112599	0.128245	0	GO:0044305,calyx of Held;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0099523,presynaptic cytosol;GO:0008091,spectrin	GO:0050681,androgen receptor binding;GO:0005524,ATP binding;GO:0005246,calcium channel regulator activity;GO:0004698,calcium-dependent protein kinase C activity;GO:0003682,chromatin binding;GO:0042393,histone binding;GO:0035403,histone kinase activity (H3-T6 specific);GO:0030374,nuclear receptor coactivator activity;GO:0004697,protein kinase C activity;GO:0005080,protein kinase C binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0008270,zinc ion binding;GO:0004672,protein kinase activity	GO:0002250,adaptive immune response;GO:0006915,apoptotic process;GO:0042113,B cell activation;GO:0050853,B cell receptor signaling pathway;GO:0006816,calcium ion transport;GO:0006874,cellular calcium ion homeostasis;GO:0071322,cellular response to carbohydrate stimulus;GO:0035408,histone H3-T6 phosphorylation;GO:0035556,intracellular signal transduction;GO:0042953,lipoprotein transport;GO:0007077,mitotic nuclear envelope disassembly;GO:0010829,negative regulation of glucose transmembrane transport;GO:0046627,negative regulation of insulin receptor signaling pathway;GO:0018105,peptidyl-serine phosphorylation;GO:0030168,platelet activation;GO:0045766,positive regulation of angiogenesis;GO:0050861,positive regulation of B cell receptor signaling pathway;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0051092,positive regulation of NF-kappaB transcription factor activity;GO:0030949,positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0099171,presynaptic modulation of chemical synaptic transmission;GO:0006468,protein phosphorylation;GO:0010827,regulation of glucose transmembrane transport;GO:0045637,regulation of myeloid cell differentiation;GO:2000300,regulation of synaptic vesicle exocytosis;GO:0006357,regulation of transcription by RNA polymerase II;GO:0007165,signal transduction	hsa:5579,path:hsa04014,Ras signaling pathway;hsa:5579,path:hsa04015,Rap1 signaling pathway;hsa:5579,path:hsa04010,MAPK signaling pathway;hsa:5579,path:hsa04012,ErbB signaling pathway;hsa:5579,path:hsa04310,Wnt signaling pathway;hsa:5579,path:hsa04370,VEGF signaling pathway;hsa:5579,path:hsa04064,NF-kappa B signaling pathway;hsa:5579,path:hsa04066,HIF-1 signaling pathway;hsa:5579,path:hsa04020,Calcium signaling pathway;hsa:5579,path:hsa04070,Phosphatidylinositol signaling system;hsa:5579,path:hsa04071,Sphingolipid signaling pathway;hsa:5579,path:hsa04150,mTOR signaling pathway;hsa:5579,path:hsa04510,Focal adhesion;hsa:5579,path:hsa04540,Gap junction;hsa:5579,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:5579,path:hsa04662,B cell receptor signaling pathway;hsa:5579,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:5579,path:hsa04670,Leukocyte transendothelial migration;hsa:5579,path:hsa04062,Chemokine signaling pathway;hsa:5579,path:hsa04911,Insulin secretion;hsa:5579,path:hsa04929,GnRH secretion;hsa:5579,path:hsa04912,GnRH signaling pathway;hsa:5579,path:hsa04921,Oxytocin signaling pathway;hsa:5579,path:hsa04935,Growth hormone synthesis, secretion and action;hsa:5579,path:hsa04918,Thyroid hormone synthesis;hsa:5579,path:hsa04919,Thyroid hormone signaling pathway;hsa:5579,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:5579,path:hsa04916,Melanogenesis;hsa:5579,path:hsa04925,Aldosterone synthesis and secretion;hsa:5579,path:hsa04270,Vascular smooth muscle contraction;hsa:5579,path:hsa04970,Salivary secretion;hsa:5579,path:hsa04971,Gastric acid secretion;hsa:5579,path:hsa04972,Pancreatic secretion;hsa:5579,path:hsa04973,Carbohydrate digestion and absorption;hsa:5579,path:hsa04960,Aldosterone-regulated sodium reabsorption;hsa:5579,path:hsa04961,Endocrine and other factor-regulated calcium reabsorption;hsa:5579,path:hsa04724,Glutamatergic synapse;hsa:5579,path:hsa04727,GABAergic synapse;hsa:5579,path:hsa04725,Cholinergic synapse;hsa:5579,path:hsa04728,Dopaminergic synapse;hsa:5579,path:hsa04726,Serotonergic synapse;hsa:5579,path:hsa04720,Long-term potentiation;hsa:5579,path:hsa04730,Long-term depression;hsa:5579,path:hsa04723,Retrograde endocannabinoid signaling;hsa:5579,path:hsa04750,Inflammatory mediator regulation of TRP channels;hsa:5579,path:hsa04713,Circadian entrainment;hsa:5579,path:hsa05200,Pathways in cancer;hsa:5579,path:hsa05206,MicroRNAs in cancer;hsa:5579,path:hsa05205,Proteoglycans in cancer;hsa:5579,path:hsa05231,Choline metabolism in cancer;hsa:5579,path:hsa05225,Hepatocellular carcinoma;hsa:5579,path:hsa05214,Glioma;hsa:5579,path:hsa05223,Non-small cell lung cancer;hsa:5579,path:hsa05017,Spinocerebellar ataxia;hsa:5579,path:hsa05031,Amphetamine addiction;hsa:5579,path:hsa05032,Morphine addiction;hsa:5579,path:hsa04931,Insulin resistance;hsa:5579,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:5579,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:5579,path:hsa05164,Influenza A;hsa:5579,path:hsa05161,Hepatitis B;hsa:5579,path:hsa05163,Human cytomegalovirus infection;hsa:5579,path:hsa05146,Amoebiasis;hsa:5579,path:hsa05140,Leishmaniasis;hsa:5579,path:hsa05143,African trypanosomiasis;hsa:5579,path:hsa01521,EGFR tyrosine kinase inhibitor resistance
SPB5_HUMAN	P36952	SERPINB5	Serpin B5	0.12976991	0.548338543	0.835055324	0.782759448	0.3390542265	0.808907386	0.3390542265	0.808907386	0.419150859997216	0.152802	0	2.38577585169846	0.153134	0	GO:0005737,cytoplasm;GO:0005615,extracellular space	GO:0004867,serine-type endopeptidase inhibitor activity	GO:0030198,extracellular matrix organization;GO:0002009,morphogenesis of an epithelium;GO:0010951,negative regulation of endopeptidase activity;GO:0060512,prostate gland morphogenesis;GO:0050678,regulation of epithelial cell proliferation	hsa:5268,path:hsa04115,p53 signaling pathway;hsa:5268,path:hsa05206,MicroRNAs in cancer
NOC3L_HUMAN	Q8WTT2	NOC3L	Nucleolar complex protein 3 homolog	0.028683118	0.038967878	0.088828741	0.026567427	0.033825498	0.057698084	0.033825498	0.057698084	0.586249935093165	0.304413	0	1.70575711849091	0.304698	0	GO:0005739,mitochondrion;GO:0016607,nuclear speck;GO:0005730,nucleolus;GO:0005654,nucleoplasm	GO:0003682,chromatin binding;GO:0003723,RNA binding	GO:0006270,DNA replication initiation;GO:0045444,fat cell differentiation	
HIP1_HUMAN	O00291	HIP1	Huntingtin-interacting protein 1	0.08918264	0.222459453	0.254972622	0.141130815	0.1558210465	0.1980517185	0.1558210465	0.1980517185	0.786769474560252	0.475215	0	1.2710203335722	0.475334	0	GO:0030136,clathrin-coated vesicle;GO:0030665,clathrin-coated vesicle membrane;GO:0005737,cytoplasm;GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0031234,extrinsic component of cytoplasmic side of plasma membrane;GO:0098890,extrinsic component of postsynaptic membrane;GO:0098888,extrinsic component of presynaptic membrane;GO:0098978,glutamatergic synapse;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005634,nucleus;GO:0098794,postsynapse;GO:0098793,presynapse	GO:0051015,actin filament binding;GO:0035612,AP-2 adaptor complex binding;GO:0035615,clathrin adaptor activity;GO:0030276,clathrin binding;GO:0032051,clathrin light chain binding;GO:0005154,epidermal growth factor receptor binding;GO:0035254,glutamate receptor binding;GO:0035091,phosphatidylinositol binding;GO:0043325,phosphatidylinositol-3,4-bisphosphate binding;GO:0080025,phosphatidylinositol-3,5-bisphosphate binding;GO:0032266,phosphatidylinositol-3-phosphate binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0005200,structural constituent of cytoskeleton	GO:0007015,actin filament organization;GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006915,apoptotic process;GO:0097190,apoptotic signaling pathway;GO:0030154,cell differentiation;GO:0048268,clathrin coat assembly;GO:0072583,clathrin-dependent endocytosis;GO:0006897,endocytosis;GO:0061024,membrane organization;GO:0099637,neurotransmitter receptor transport;GO:0045742,positive regulation of epidermal growth factor receptor signaling pathway;GO:2000588,positive regulation of platelet-derived growth factor receptor-beta signaling pathway;GO:0051897,positive regulation of protein kinase B signaling;GO:0048260,positive regulation of receptor-mediated endocytosis;GO:0050821,protein stabilization;GO:0042981,regulation of apoptotic process;GO:0030100,regulation of endocytosis	hsa:3092,path:hsa05016,Huntington disease
ACSL4_HUMAN	O60488	ACSL4	Long-chain-fatty-acid--CoA ligase 4	0.247182136	0.1985886	0.328384813	0.191142273	0.222885368	0.259763543	0.222885368	0.259763543	0.858031752361801	0.484527	0	1.16545803491237	0.484443	0	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0005811,lipid droplet;GO:0016020,membrane;GO:0044233,mitochondria-associated endoplasmic reticulum membrane;GO:0005741,mitochondrial outer membrane;GO:0043025,neuronal cell body;GO:0005778,peroxisomal membrane;GO:0005886,plasma membrane	GO:0047676,arachidonate-CoA ligase activity;GO:0005524,ATP binding;GO:0004467,long-chain fatty acid-CoA ligase activity;GO:0031957,very long-chain fatty acid-CoA ligase activity	GO:0060996,dendritic spine development;GO:0060136,embryonic process involved in female pregnancy;GO:0006631,fatty acid metabolic process;GO:0015908,fatty acid transport;GO:0008610,lipid biosynthetic process;GO:0006629,lipid metabolic process;GO:0001676,long-chain fatty acid metabolic process;GO:0035338,long-chain fatty-acyl-CoA biosynthetic process;GO:0035336,long-chain fatty-acyl-CoA metabolic process;GO:0032307,negative regulation of prostaglandin secretion;GO:0030182,neuron differentiation;GO:0030307,positive regulation of cell growth;GO:0032024,positive regulation of insulin secretion;GO:0070672,response to interleukin-15;GO:0007584,response to nutrient;GO:0019432,triglyceride biosynthetic process	hsa:2182,path:hsa00061,Fatty acid biosynthesis;hsa:2182,path:hsa00071,Fatty acid degradation;hsa:2182,path:hsa04146,Peroxisome;hsa:2182,path:hsa04216,Ferroptosis;hsa:2182,path:hsa04920,Adipocytokine signaling pathway;hsa:2182,path:hsa03320,PPAR signaling pathway;hsa:2182,path:hsa04714,Thermogenesis
PRP4B_HUMAN	Q13523	PRPF4B	Serine/threonine-protein kinase PRP4 homolog	0.424685497	0.296484776	0.497864893	1.357466858	0.3605851365	0.9276658755	0.3605851365	0.9276658755	0.388701520691002	0.127196	0	2.57266809304548	0.127516	0	GO:0071013,catalytic step 2 spliceosome;GO:0005694,chromosome;GO:0016607,nuclear speck;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0004672,protein kinase activity;GO:0106310,protein serine kinase activity;GO:0106311,protein threonine kinase activity;GO:0003723,RNA binding	GO:0045292,mRNA cis splicing, via spliceosome;GO:0000398,mRNA splicing, via spliceosome;GO:0006468,protein phosphorylation;GO:0008380,RNA splicing	
SYIM_HUMAN	Q9NSE4	IARS2	Isoleucine--tRNA ligase, mitochondrial	1.843165749	2.59168147	2.255335664	2.537441752	2.2174236095	2.396388708	2.2174236095	2.396388708	0.925318835837212	0.459208	0	1.08070857446149	0.459068	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0002161,aminoacyl-tRNA editing activity;GO:0005524,ATP binding;GO:0004822,isoleucine-tRNA ligase activity;GO:0000049,tRNA binding	GO:0006428,isoleucyl-tRNA aminoacylation;GO:0032543,mitochondrial translation;GO:0006418,tRNA aminoacylation for protein translation	hsa:55699,path:hsa00970,Aminoacyl-tRNA biosynthesis
OGFR_HUMAN	Q9NZT2	OGFR	Opioid growth factor receptor	0.190686464	0.248032712	0.305577598	0.048283576	0.219359588	0.176930587	0.219359588	0.176930587	1.23980591326473	0.363535	0	0.806577859728657	0.363195	0	GO:0005737,cytoplasm;GO:0016020,membrane;GO:0005634,nucleus	GO:0004985,opioid receptor activity	GO:0001558,regulation of cell growth	
HS12B_HUMAN	Q96MM6	HSPA12B	Heat shock 70 kDa protein 12B	0.009511303	0.155589579	0.180429421	1.507570981	0.082550441	0.844000201	0.082550441	0.844000201	0.0978085560906164	0.000580	-1	10.2240544178316	0.000588	1		GO:0005524,ATP binding		
PXDC2_HUMAN	Q6UX71	PLXDC2	Plexin domain-containing protein 2	0.522250209	0.717495868	0.361740694	1.892863837	0.6198730385	1.1273022655	0.6198730385	1.1273022655	0.54987296439528	0.271048	0	1.81860186761454	0.271355	0	GO:0016021,integral component of membrane			
VDAC2_HUMAN	P45880	VDAC2	Voltage-dependent anion-selective channel protein 2	12.33662596	19.00866275	11.17826586	8.123666284	15.672644355	9.650966072	15.672644355	9.650966072	1.62394564835022	0.282132	0	0.615784155717225	0.281655	0	GO:0001669,acrosomal vesicle;GO:0016020,membrane;GO:0045121,membrane raft;GO:0031966,mitochondrial membrane;GO:0042645,mitochondrial nucleoid;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0046930,pore complex;GO:0008021,synaptic vesicle	GO:0097001,ceramide binding;GO:0015485,cholesterol binding;GO:0000166,nucleotide binding;GO:0031210,phosphatidylcholine binding;GO:0015288,porin activity;GO:0008308,voltage-gated anion channel activity	GO:0006820,anion transport;GO:0007339,binding of sperm to zona pellucida;GO:0097345,mitochondrial outer membrane permeabilization;GO:2001243,negative regulation of intrinsic apoptotic signaling pathway;GO:0032272,negative regulation of protein polymerization	hsa:7417,path:hsa04020,Calcium signaling pathway;hsa:7417,path:hsa04022,cGMP-PKG signaling pathway;hsa:7417,path:hsa04216,Ferroptosis;hsa:7417,path:hsa04217,Necroptosis;hsa:7417,path:hsa04218,Cellular senescence;hsa:7417,path:hsa04621,NOD-like receptor signaling pathway;hsa:7417,path:hsa04979,Cholesterol metabolism;hsa:7417,path:hsa05012,Parkinson disease;hsa:7417,path:hsa05016,Huntington disease;hsa:7417,path:hsa05166,Human T-cell leukemia virus 1 infection
LAMB2_HUMAN	P55268	LAMB2	Laminin subunit beta-2	5.305349009	2.833366031	6.077966885	34.07773694	4.06935752	20.0778519125	4.06935752	20.0778519125	0.20267892888813	0.016384	-1	4.93391200301811	0.016494	1	GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0043256,laminin complex;GO:0043260,laminin-11 complex;GO:0005608,laminin-3 complex;GO:0031594,neuromuscular junction;GO:0043083,synaptic cleft	GO:0005201,extracellular matrix structural constituent;GO:0005178,integrin binding;GO:0005198,structural molecule activity	GO:0009887,animal organ morphogenesis;GO:0014002,astrocyte development;GO:0048677,axon extension involved in regeneration;GO:0007411,axon guidance;GO:0070831,basement membrane assembly;GO:0016477,cell migration;GO:0044267,cellular protein metabolic process;GO:0030198,extracellular matrix organization;GO:0072274,metanephric glomerular basement membrane development;GO:0072249,metanephric glomerular visceral epithelial cell development;GO:0007528,neuromuscular junction development;GO:0043687,post-translational protein modification;GO:0060041,retina development in camera-type eye;GO:0014044,Schwann cell development;GO:0034446,substrate adhesion-dependent cell spreading;GO:0009888,tissue development;GO:0007601,visual perception	hsa:3913,path:hsa04151,PI3K-Akt signaling pathway;hsa:3913,path:hsa04512,ECM-receptor interaction;hsa:3913,path:hsa04510,Focal adhesion;hsa:3913,path:hsa05200,Pathways in cancer;hsa:3913,path:hsa05222,Small cell lung cancer;hsa:3913,path:hsa05165,Human papillomavirus infection;hsa:3913,path:hsa05146,Amoebiasis;hsa:3913,path:hsa05145,Toxoplasmosis
MRE11_HUMAN	P49959	MRE11	Double-strand break repair protein MRE11	1.538968793	1.10906613	3.597646454	1.895162967	1.3240174615	2.7464047105	1.3240174615	2.7464047105	0.48209117048119	0.208772	0	2.0742964427286	0.209105	0	GO:0000781,chromosome, telomeric region;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030870,Mre11 complex;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016605,PML body;GO:0005657,replication fork;GO:0035861,site of double-strand break	GO:0008408,3'-5' exonuclease activity;GO:0008296,3'-5'-exodeoxyribonuclease activity;GO:0008409,5'-3' exonuclease activity;GO:0045296,cadherin binding;GO:0003690,double-stranded DNA binding;GO:0004520,endodeoxyribonuclease activity;GO:0042802,identical protein binding;GO:0030145,manganese ion binding;GO:0004518,nuclease activity;GO:0008022,protein C-terminus binding;GO:0000014,single-stranded DNA endodeoxyribonuclease activity;GO:0016787,hydrolase activity	GO:0008283,cell population proliferation;GO:0006974,cellular response to DNA damage stimulus;GO:0000729,DNA double-strand break processing;GO:0032508,DNA duplex unwinding;GO:0006310,DNA recombination;GO:0006281,DNA repair;GO:0006260,DNA replication;GO:0110025,DNA strand resection involved in replication fork processing;GO:0006302,double-strand break repair;GO:0000724,double-strand break repair via homologous recombination;GO:0006303,double-strand break repair via nonhomologous end joining;GO:0007129,homologous chromosome pairing at meiosis;GO:0031573,intra-S DNA damage checkpoint;GO:0042138,meiotic DNA double-strand break formation;GO:0097552,mitochondrial double-strand break repair via homologous recombination;GO:0007095,mitotic G2 DNA damage checkpoint;GO:0043066,negative regulation of apoptotic process;GO:0033674,positive regulation of kinase activity;GO:0031954,positive regulation of protein autophosphorylation;GO:0032206,positive regulation of telomere maintenance;GO:0032481,positive regulation of type I interferon production;GO:0007131,reciprocal meiotic recombination;GO:0000019,regulation of mitotic recombination;GO:1901796,regulation of signal transduction by p53 class mediator;GO:0007062,sister chromatid cohesion;GO:0000723,telomere maintenance;GO:0007004,telomere maintenance via telomerase;GO:0031860,telomeric 3' overhang formation;GO:0016032,viral process;GO:0051321,meiotic cell cycle	hsa:4361,path:hsa03440,Homologous recombination;hsa:4361,path:hsa03450,Non-homologous end-joining;hsa:4361,path:hsa04218,Cellular senescence
IGLL5_HUMAN	B9A064	IGLL5	Immunoglobulin lambda-like polypeptide 5	26.13666021	27.41552476	18.18452685	36.27473	26.776092485	27.229628425	26.776092485	27.229628425	0.98334402758197	0.438926	0	1.01693809282494	0.438742	0	GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0042571,immunoglobulin complex, circulating	GO:0003823,antigen binding;GO:0034987,immunoglobulin receptor binding	GO:0050853,B cell receptor signaling pathway;GO:0006958,complement activation, classical pathway;GO:0042742,defense response to bacterium;GO:0045087,innate immune response;GO:0006911,phagocytosis, engulfment;GO:0006910,phagocytosis, recognition;GO:0050871,positive regulation of B cell activation	
PCOC1_HUMAN	Q15113	PCOLCE	Procollagen C-endopeptidase enhancer 1	0.21568647	0.32793646	0.260300013	0.403211136	0.271811465	0.3317555745	0.271811465	0.3317555745	0.819312427258099	0.499909	0	1.22053561831912	0.500000	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space	GO:0005518,collagen binding;GO:0008201,heparin binding;GO:0016504,peptidase activator activity	GO:0007275,multicellular organism development	
TGON2_HUMAN	O43493	TGOLN2	Trans-Golgi network integral membrane protein 2	0.051141953	0.076278847	0.083962406	0.047495002	0.0637104	0.065728704	0.0637104	0.065728704	0.969293415552511	0.443713	0	1.03167934905447	0.443539	0	GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0005788,endoplasmic reticulum lumen;GO:0005768,endosome;GO:0005794,Golgi apparatus;GO:0016021,integral component of membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0005802,trans-Golgi network;GO:0030140,trans-Golgi network transport vesicle;GO:0030133,transport vesicle		GO:0044267,cellular protein metabolic process;GO:0061024,membrane organization;GO:0043687,post-translational protein modification	
RTCB_HUMAN	Q9Y3I0	RTCB	RNA-splicing ligase RtcB homolog	6.0012815	6.556536508	8.318600718	7.193307207	6.278909004	7.7559539625	6.278909004	7.7559539625	0.809559859993818	0.492609	0	1.23523910882592	0.492708	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0043231,intracellular membrane-bounded organelle;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0072669,tRNA-splicing ligase complex	GO:0005525,GTP binding;GO:0046872,metal ion binding;GO:0003723,RNA binding;GO:0003972,RNA ligase (ATP) activity;GO:0017166,vinculin binding	GO:0000971,tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate;GO:0006388,tRNA splicing, via endonucleolytic cleavage and ligation	
SYLC_HUMAN	Q9P2J5	LARS1	Leucine--tRNA ligase, cytoplasmic	2.413308449	2.168748438	3.258693636	2.449746832	2.2910284435	2.854220234	2.2910284435	2.854220234	0.802681032181345	0.487408	0	1.24582487925799	0.487513	0	GO:0017101,aminoacyl-tRNA synthetase multienzyme complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0012505,endomembrane system;GO:0005783,endoplasmic reticulum;GO:0005764,lysosome;GO:0016604,nuclear body	GO:0002161,aminoacyl-tRNA editing activity;GO:0005524,ATP binding;GO:0004819,glutamine-tRNA ligase activity;GO:0005096,GTPase activator activity;GO:0004823,leucine-tRNA ligase activity	GO:0034198,cellular response to amino acid starvation;GO:0071230,cellular response to amino acid stimulus;GO:0071233,cellular response to leucine;GO:1990253,cellular response to leucine starvation;GO:0006425,glutaminyl-tRNA aminoacylation;GO:0006429,leucyl-tRNA aminoacylation;GO:0043547,positive regulation of GTPase activity;GO:0032008,positive regulation of TOR signaling;GO:1904263,positive regulation of TORC1 signaling;GO:0008361,regulation of cell size;GO:0006418,tRNA aminoacylation for protein translation	hsa:51520,path:hsa00970,Aminoacyl-tRNA biosynthesis
PSD12_HUMAN	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	1.885016727	1.724761618	3.531744167	3.549186308	1.8048891725	3.5404652375	1.8048891725	3.5404652375	0.509788700474425	0.234128	0	1.9615970284735	0.234454	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0016020,membrane;GO:0031595,nuclear proteasome complex;GO:0005654,nucleoplasm;GO:0022624,proteasome accessory complex;GO:0000502,proteasome complex;GO:0005838,proteasome regulatory particle;GO:0008541,proteasome regulatory particle, lid subcomplex;GO:0034774,secretory granule lumen		GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0043312,neutrophil degranulation;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5718,path:hsa03050,Proteasome;hsa:5718,path:hsa05169,Epstein-Barr virus infection
LYPA1_HUMAN	O75608	LYPLA1	Acyl-protein thioesterase 1	2.093061316	3.693165637	0.862750001	0.687487119	2.8931134765	0.77511856	2.8931134765	0.77511856	3.73247865010483	0.100632	0	0.267918478240167	0.100107	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0031965,nuclear membrane;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0052689,carboxylic ester hydrolase activity;GO:0016298,lipase activity;GO:0004622,lysophospholipase activity;GO:0008474,palmitoyl-(protein) hydrolase activity;GO:0004620,phospholipase activity;GO:0016787,hydrolase activity	GO:0006631,fatty acid metabolic process;GO:0000165,MAPK cascade;GO:0042997,negative regulation of Golgi to plasma membrane protein transport;GO:0002084,protein depalmitoylation;GO:0050999,regulation of nitric-oxide synthase activity	hsa:10434,path:hsa00564,Glycerophospholipid metabolism;hsa:10434,path:hsa05231,Choline metabolism in cancer
GRSF1_HUMAN	Q12849	GRSF1	G-rich sequence factor 1	0.248321377	0.157882264	0.029308335	0.054598135	0.2031018205	0.041953235	0.2031018205	0.041953235	4.84114801874039	0.067174	0	0.206562574853927	0.066724	0	GO:0005737,cytoplasm;GO:0042645,mitochondrial nucleoid;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:1990904,ribonucleoprotein complex;GO:0035770,ribonucleoprotein granule	GO:0003729,mRNA binding;GO:0003723,RNA binding	GO:0009952,anterior/posterior pattern specification;GO:0016331,morphogenesis of embryonic epithelium;GO:0006378,mRNA polyadenylation;GO:0000962,positive regulation of mitochondrial RNA catabolic process;GO:0043484,regulation of RNA splicing;GO:0008033,tRNA processing;GO:0006396,RNA processing	
NASP_HUMAN	P49321	NASP	Nuclear autoantigenic sperm protein	1.03851285	0.273258715	1.044305185	0.556056077	0.6558857825	0.800180631	0.6558857825	0.800180631	0.819672155373628	0.499902	0	1.21999996394189	0.499852	0	GO:0000785,chromatin;GO:0005737,cytoplasm;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0042393,histone binding;GO:0044877,protein-containing complex binding	GO:0001824,blastocyst development;GO:0034080,CENP-A containing nucleosome assembly;GO:0006260,DNA replication;GO:0006335,DNA replication-dependent nucleosome assembly;GO:0006336,DNA replication-independent nucleosome assembly;GO:0000082,G1/S transition of mitotic cell cycle;GO:0043486,histone exchange;GO:0008584,male gonad development;GO:0006334,nucleosome assembly;GO:0015031,protein transport;GO:0033574,response to testosterone	
KRT81_HUMAN	Q14533	KRT81	Keratin, type II cuticular Hb1	0.037997394	0.128186044	0.036299761	0.063703623	0.083091719	0.050001692	0.083091719	0.050001692	1.66177814542756	0.275611	0	0.601765044721244	0.275125	0	GO:0005829,cytosol;GO:0005615,extracellular space;GO:0045095,keratin filament		GO:0070268,cornification;GO:0031424,keratinization	
RPN2_HUMAN	P04844	RPN2	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2	10.66639496	10.81395946	21.61236479	12.18576758	10.74017721	16.899066185	10.74017721	16.899066185	0.635548561821317	0.348875	0	1.57344388780341	0.349124	0	GO:0000421,autophagosome membrane;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0016604,nuclear body;GO:0008250,oligosaccharyltransferase complex;GO:0005791,rough endoplasmic reticulum	GO:0043022,ribosome binding	GO:0007568,aging;GO:0006464,cellular protein modification process;GO:0006487,protein N-linked glycosylation;GO:0018279,protein N-linked glycosylation via asparagine;GO:0042493,response to drug;GO:0019082,viral protein processing	hsa:6185,path:hsa00510,N-Glycan biosynthesis;hsa:6185,path:hsa00513,Various types of N-glycan biosynthesis;hsa:6185,path:hsa04141,Protein processing in endoplasmic reticulum
CDC73_HUMAN	Q6P1J9	CDC73	Parafibromin	0.091499857	0.174782795	0.086484202	0.974194199	0.133141326	0.5303392005	0.133141326	0.5303392005	0.251049377218345	0.035317	-1	3.983280146241	0.035497	1	GO:0016593,Cdc73/Paf1 complex;GO:0000781,chromosome, telomeric region;GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0000993,RNA polymerase II complex binding	GO:1904837,beta-catenin-TCF complex assembly;GO:0007049,cell cycle;GO:0071222,cellular response to lipopolysaccharide;GO:0001711,endodermal cell fate commitment;GO:0033523,histone H2B ubiquitination;GO:0010390,histone monoubiquitination;GO:0006378,mRNA polyadenylation;GO:0043066,negative regulation of apoptotic process;GO:0008285,negative regulation of cell population proliferation;GO:0050680,negative regulation of epithelial cell proliferation;GO:0048147,negative regulation of fibroblast proliferation;GO:2000134,negative regulation of G1/S transition of mitotic cell cycle;GO:0045638,negative regulation of myeloid cell differentiation;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:1902808,positive regulation of cell cycle G1/S phase transition;GO:0031442,positive regulation of mRNA 3'-end processing;GO:0032968,positive regulation of transcription elongation from RNA polymerase II promoter;GO:0030177,positive regulation of Wnt signaling pathway;GO:0031648,protein destabilization;GO:0016567,protein ubiquitination;GO:0034402,recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex;GO:0001558,regulation of cell growth;GO:0019827,stem cell population maintenance;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter;GO:0016055,Wnt signaling pathway;GO:0016570,histone modification	
ENTP1_HUMAN	P49961	ENTPD1	Ectonucleoside triphosphate diphosphohydrolase 1	1.155518168	2.136193809	1.345158566	5.901066781	1.6458559885	3.6231126735	1.6458559885	3.6231126735	0.45426574794045	0.183650	0	2.2013546135358	0.183986	0	GO:0070062,extracellular exosome;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0016021,integral component of membrane	GO:0102490,8-oxo-dGTP phosphohydrolase activity;GO:0005524,ATP binding;GO:0102485,dATP phosphohydrolase activity;GO:0102486,dCTP phosphohydrolase activity;GO:0102491,dGTP phosphohydrolase activity;GO:0102488,dTTP phosphohydrolase activity;GO:0102487,dUTP phosphohydrolase activity;GO:0102489,GTP phosphohydrolase activity;GO:0004382,guanosine-diphosphatase activity;GO:0017110,nucleoside-diphosphatase activity;GO:0045134,uridine-diphosphatase activity;GO:0016787,hydrolase activity	GO:0007596,blood coagulation;GO:0007155,cell adhesion;GO:0034656,nucleobase-containing small molecule catabolic process;GO:0009134,nucleoside diphosphate catabolic process;GO:0035590,purinergic nucleotide receptor signaling pathway	hsa:953,path:hsa00230,Purine metabolism;hsa:953,path:hsa00240,Pyrimidine metabolism;hsa:953,path:hsa05169,Epstein-Barr virus infection
ARF6_HUMAN	P62330	ARF6	ADP-ribosylation factor 6	1.809086052	5.017866415	0.233937388	0.024267896	3.4134762335	0.129102642	3.4134762335	0.129102642	26.4400184273533	0.001705	1	0.0378214562424607	0.001669	-1	GO:0005938,cell cortex;GO:0032154,cleavage furrow;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0030139,endocytic vesicle;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0031527,filopodium membrane;GO:0090543,Flemming body;GO:0005925,focal adhesion;GO:0098978,glutamatergic synapse;GO:0005794,Golgi apparatus;GO:0016020,membrane;GO:0005886,plasma membrane;GO:0098793,presynapse;GO:0055038,recycling endosome membrane;GO:0001726,ruffle	GO:0019003,GDP binding;GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0047485,protein N-terminus binding;GO:0031996,thioesterase binding	GO:0007155,cell adhesion;GO:0007049,cell cycle;GO:0030154,cell differentiation;GO:0051301,cell division;GO:1990090,cellular response to nerve growth factor stimulus;GO:0030866,cortical actin cytoskeleton organization;GO:0032456,endocytic recycling;GO:0090162,establishment of epithelial cell polarity;GO:0097284,hepatocyte apoptotic process;GO:0006886,intracellular protein transport;GO:0001889,liver development;GO:0099562,maintenance of postsynaptic density structure;GO:0033028,myeloid cell apoptotic process;GO:2000171,negative regulation of dendrite development;GO:2000009,negative regulation of protein localization to cell surface;GO:0048261,negative regulation of receptor-mediated endocytosis;GO:0007399,nervous system development;GO:0030838,positive regulation of actin filament polymerization;GO:0120183,positive regulation of focal adhesion disassembly;GO:0051549,positive regulation of keratinocyte migration;GO:1903078,positive regulation of protein localization to plasma membrane;GO:0050714,positive regulation of protein secretion;GO:0034394,protein localization to cell surface;GO:0036010,protein localization to endosome;GO:0060998,regulation of dendritic spine development;GO:0051489,regulation of filopodium assembly;GO:1905606,regulation of presynapse assembly;GO:0035020,regulation of Rac protein signal transduction;GO:0097178,ruffle assembly;GO:0048488,synaptic vesicle endocytosis;GO:0016192,vesicle-mediated transport	hsa:382,path:hsa04014,Ras signaling pathway;hsa:382,path:hsa04072,Phospholipase D signaling pathway;hsa:382,path:hsa04144,Endocytosis;hsa:382,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:382,path:hsa05130,Pathogenic Escherichia coli infection;hsa:382,path:hsa05132,Salmonella infection;hsa:382,path:hsa05135,Yersinia infection
RETR3_HUMAN	Q86VR2	RETREG3	Reticulophagy regulator 3	0.280923005	0.340475189	0.313021241	0.180528755	0.310699097	0.246774998	0.310699097	0.246774998	1.25903798811904	0.358676	0	0.794257210216482	0.358327	0	GO:0016021,integral component of membrane;GO:0032991,protein-containing complex		GO:0010976,positive regulation of neuron projection development;GO:0061709,reticulophagy	
TBG1_HUMAN	P23258	TUBG1	Tubulin gamma-1 chain	0.809254576	0.153062508	0.721195745	0.456281042	0.481158542	0.5887383935	0.481158542	0.5887383935	0.817270535287419	0.498388	0	1.22358503925303	0.498480	0	GO:0005813,centrosome;GO:0000794,condensed nuclear chromosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0000930,gamma-tubulin complex;GO:0005874,microtubule;GO:1990498,mitotic spindle microtubule;GO:0005634,nucleus;GO:0005827,polar microtubule;GO:0055037,recycling endosome;GO:0005819,spindle	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0005200,structural constituent of cytoskeleton	GO:0097711,ciliary basal body-plasma membrane docking;GO:0031122,cytoplasmic microtubule organization;GO:0000086,G2/M transition of mitotic cell cycle;GO:0000212,meiotic spindle organization;GO:0000226,microtubule cytoskeleton organization;GO:0007020,microtubule nucleation;GO:0000278,mitotic cell cycle;GO:0000070,mitotic sister chromatid segregation;GO:0007052,mitotic spindle organization;GO:0010389,regulation of G2/M transition of mitotic cell cycle	hsa:7283,path:hsa05165,Human papillomavirus infection
DRG1_HUMAN	Q9Y295	DRG1	Developmentally-regulated GTP-binding protein 1	4.444385365	5.13637391	7.960567637	6.159801809	4.7903796375	7.060184723	4.7903796375	7.060184723	0.678506275040419	0.386518	0	1.47382572097867	0.386732	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0016604,nuclear body;GO:0005634,nucleus;GO:0005844,polysome	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding;GO:0008017,microtubule binding;GO:0030955,potassium ion binding;GO:0008134,transcription factor binding	GO:0002181,cytoplasmic translation;GO:0007275,multicellular organism development;GO:0031116,positive regulation of microtubule polymerization;GO:1901673,regulation of mitotic spindle assembly;GO:0006351,transcription, DNA-templated	
EPN4_HUMAN	Q14677	CLINT1	Clathrin interactor 1	0.565719173	0.483720899	0.571580424	0.333288723	0.524720036	0.4524345735	0.524720036	0.4524345735	1.15976997942665	0.384845	0	0.86223994217747	0.384548	0	GO:0030125,clathrin vesicle coat;GO:0005829,cytosol;GO:0005768,endosome;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0005654,nucleoplasm;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane	GO:0045296,cadherin binding;GO:0030276,clathrin binding;GO:0005543,phospholipid binding	GO:0048268,clathrin coat assembly;GO:0006897,endocytosis;GO:0006892,post-Golgi vesicle-mediated transport	
AFG2H_HUMAN	Q8NB90	SPATA5	ATPase family protein 2 homolog	0.052982915	2.55E-05	0.062375317	2.55E-05	0.0265042075	0.0312004085	0.0265042075	0.0312004085	0.849482707894674	0.487892	0	1.17718699946037	0.487815	0	GO:0005737,cytoplasm;GO:0005739,mitochondrion;GO:0005819,spindle	GO:0005524,ATP binding;GO:0016887,ATPase activity	GO:0007420,brain development;GO:0030154,cell differentiation;GO:0007283,spermatogenesis	hsa:166378,path:hsa03008,Ribosome biogenesis in eukaryotes
PAPS1_HUMAN	O43252	PAPSS1	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1	0.311677939	0.279096672	0.29966203	0.068052784	0.2953873055	0.183857407	0.2953873055	0.183857407	1.60661085305092	0.285197	0	0.622428261393244	0.284724	0	GO:0005829,cytosol	GO:0004020,adenylylsulfate kinase activity;GO:0005524,ATP binding;GO:0016779,nucleotidyltransferase activity;GO:0042803,protein homodimerization activity;GO:0004781,sulfate adenylyltransferase (ATP) activity	GO:0050428,3'-phosphoadenosine 5'-phosphosulfate biosynthetic process;GO:0001501,skeletal system development;GO:0000103,sulfate assimilation	hsa:9061,path:hsa00920,Sulfur metabolism;hsa:9061,path:hsa00230,Purine metabolism;hsa:9061,path:hsa00450,Selenocompound metabolism
PDIA1_HUMAN	P07237	P4HB	Protein disulfide-isomerase	61.82178331	45.24781113	79.44943007	45.37917239	53.53479722	62.41430123	53.53479722	62.41430123	0.85773286194011	0.484644	0	1.16586415698018	0.484560	0	GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005793,endoplasmic reticulum-Golgi intermediate compartment;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0042470,melanosome;GO:0016222,procollagen-proline 4-dioxygenase complex;GO:0032991,protein-containing complex	GO:0003779,actin binding;GO:0005178,integrin binding;GO:0015037,peptide disulfide oxidoreductase activity;GO:0004656,procollagen-proline 4-dioxygenase activity;GO:0003756,protein disulfide isomerase activity;GO:0046982,protein heterodimerization activity;GO:0003723,RNA binding;GO:0016972,thiol oxidase activity;GO:0051213,dioxygenase activity	GO:0044267,cellular protein metabolic process;GO:0071456,cellular response to hypoxia;GO:0034378,chylomicron assembly;GO:0030199,collagen fibril organization;GO:0035722,interleukin-12-mediated signaling pathway;GO:0038155,interleukin-23-mediated signaling pathway;GO:0018401,peptidyl-proline hydroxylation to 4-hydroxy-L-proline;GO:0045785,positive regulation of cell adhesion;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0046598,positive regulation of viral entry into host cell;GO:0043687,post-translational protein modification;GO:0006457,protein folding;GO:0034975,protein folding in endoplasmic reticulum;GO:1902175,regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:0034976,response to endoplasmic reticulum stress;GO:0034379,very-low-density lipoprotein particle assembly	hsa:5034,path:hsa04141,Protein processing in endoplasmic reticulum
APOD_HUMAN	P05090	APOD	Apolipoprotein D	1.419232501	1.871477861	1.049093329	10.37608287	1.645355181	5.7125880995	1.645355181	5.7125880995	0.28802272321087	0.055037	0	3.47194828537146	0.055267	0	GO:0005737,cytoplasm;GO:0022626,cytosolic ribosome;GO:0030425,dendrite;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0043025,neuronal cell body;GO:0048471,perinuclear region of cytoplasm	GO:0015485,cholesterol binding;GO:0005319,lipid transporter activity;GO:0008289,lipid binding	GO:0007568,aging;GO:0001525,angiogenesis;GO:0007420,brain development;GO:0006006,glucose metabolic process;GO:0030522,intracellular receptor signaling pathway;GO:0006629,lipid metabolic process;GO:1900016,negative regulation of cytokine production involved in inflammatory response;GO:0051895,negative regulation of focal adhesion assembly;GO:0060588,negative regulation of lipoprotein lipid oxidation;GO:0071638,negative regulation of monocyte chemotactic protein-1 production;GO:0010642,negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0042308,negative regulation of protein import into nucleus;GO:0048662,negative regulation of smooth muscle cell proliferation;GO:2000098,negative regulation of smooth muscle cell-matrix adhesion;GO:2000405,negative regulation of T cell migration;GO:0014012,peripheral nervous system axon regeneration;GO:0048678,response to axon injury;GO:0042493,response to drug;GO:0000302,response to reactive oxygen species;GO:0042246,tissue regeneration;GO:0006869,lipid transport	
DGKA_HUMAN	P23743	DGKA	Diacylglycerol kinase alpha	0.05657889	0.053466151	0.125642702	0.015416585	0.0550225205	0.0705296435	0.0550225205	0.0705296435	0.780133257018377	0.470063	0	1.28183229083444	0.470188	0	GO:0005829,cytosol;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0005524,ATP binding;GO:0005509,calcium ion binding;GO:0004143,diacylglycerol kinase activity;GO:0016301,kinase activity;GO:0008289,lipid binding;GO:0003951,NAD+ kinase activity;GO:0005543,phospholipid binding;GO:0046872,metal ion binding	GO:0046339,diacylglycerol metabolic process;GO:0046486,glycerolipid metabolic process;GO:0035556,intracellular signal transduction;GO:0046834,lipid phosphorylation;GO:0006654,phosphatidic acid biosynthetic process;GO:0030168,platelet activation;GO:0007205,protein kinase C-activating G protein-coupled receptor signaling pathway;GO:0007165,signal transduction	hsa:1606,path:hsa00561,Glycerolipid metabolism;hsa:1606,path:hsa00564,Glycerophospholipid metabolism;hsa:1606,path:hsa04070,Phosphatidylinositol signaling system;hsa:1606,path:hsa04072,Phospholipase D signaling pathway;hsa:1606,path:hsa05231,Choline metabolism in cancer
NELFB_HUMAN	Q8WX92	NELFB	Negative elongation factor B	0.20896581	0.111819203	0.282587192	0.19847243	0.1603925065	0.240529811	0.1603925065	0.240529811	0.666830052512701	0.376406	0	1.49963247191975	0.376630	0	GO:0005737,cytoplasm;GO:0032021,NELF complex;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003723,RNA binding	GO:0008283,cell population proliferation;GO:2000737,negative regulation of stem cell differentiation;GO:0034244,negative regulation of transcription elongation from RNA polymerase II promoter;GO:0050434,positive regulation of viral transcription;GO:0048863,stem cell differentiation;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter;GO:0045892,negative regulation of transcription, DNA-templated	
AK1A1_HUMAN	P14550	AKR1A1	Aldo-keto reductase family 1 member A1	12.00167433	13.52417367	17.57465335	12.14582108	12.762924	14.860237215	12.762924	14.860237215	0.858864082406238	0.484201	0	1.16432858293288	0.484116	0	GO:0016324,apical plasma membrane;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0045202,synapse	GO:0004032,alditol;GO:0047655,allyl-alcohol dehydrogenase activity;GO:0047834,D-threo-aldose 1-dehydrogenase activity;GO:0009055,electron transfer activity;GO:0047941,glucuronolactone reductase activity;GO:0047956,glycerol dehydrogenase [NADP+] activity;GO:0047939,L-glucuronate reductase activity;GO:1990002,methylglyoxal reductase (NADPH-dependent, acetol producing)	GO:0046185,aldehyde catabolic process;GO:0006081,cellular aldehyde metabolic process;GO:0110095,cellular detoxification of aldehyde;GO:0042840,D-glucuronate catabolic process;GO:0044597,daunorubicin metabolic process;GO:0044598,doxorubicin metabolic process;GO:0006006,glucose metabolic process;GO:0019640,glucuronate catabolic process to xylulose 5-phosphate;GO:1901687,glutathione derivative biosynthetic process;GO:0019853,L-ascorbic acid biosynthetic process	hsa:10327,path:hsa00010,Glycolysis / Gluconeogenesis;hsa:10327,path:hsa00040,Pentose and glucuronate interconversions;hsa:10327,path:hsa00561,Glycerolipid metabolism
ATLA2_HUMAN	Q8NHH9	ATL2	Atlastin-2	0.29861583	0.140739626	0.254824299	0.221944269	0.219677728	0.238384284	0.219677728	0.238384284	0.9215277295713	0.460582	0	1.08515454056408	0.460444	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0098826,endoplasmic reticulum tubular network membrane;GO:0016021,integral component of membrane;GO:0016020,membrane	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding	GO:0007029,endoplasmic reticulum organization;GO:1990809,endoplasmic reticulum tubular network membrane organization;GO:0007030,Golgi organization;GO:0051260,protein homooligomerization	
PSA5_HUMAN	P28066	PSMA5	Proteasome subunit alpha type-5	5.408233971	3.646817685	5.776072006	3.249023638	4.527525828	4.512547822	4.527525828	4.512547822	1.00331919053067	0.432253	0	0.99669179004847	0.432054	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:1904813,ficolin-1-rich granule lumen;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000502,proteasome complex;GO:0005839,proteasome core complex;GO:0019773,proteasome core complex, alpha-subunit complex;GO:0034774,secretory granule lumen	GO:0004175,endopeptidase activity	GO:0031145,anaphase-promoting complex-dependent catabolic process;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0070498,interleukin-1-mediated signaling pathway;GO:0000165,MAPK cascade;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0010972,negative regulation of G2/M transition of mitotic cell cycle;GO:0043312,neutrophil degranulation;GO:0038061,NIK/NF-kappaB signaling;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0043687,post-translational protein modification;GO:0036388,pre-replicative complex assembly;GO:0010499,proteasomal ubiquitin-independent protein catabolic process;GO:0043161,proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016579,protein deubiquitination;GO:0000209,protein polyubiquitination;GO:0006521,regulation of cellular amino acid metabolic process;GO:1902036,regulation of hematopoietic stem cell differentiation;GO:1901990,regulation of mitotic cell cycle phase transition;GO:0043488,regulation of mRNA stability;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0031146,SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0050852,T cell receptor signaling pathway;GO:0055085,transmembrane transport;GO:0033209,tumor necrosis factor-mediated signaling pathway;GO:0060071,Wnt signaling pathway, planar cell polarity pathway	hsa:5686,path:hsa03050,Proteasome
GSTM3_HUMAN	P21266	GSTM3	Glutathione S-transferase Mu 3	1.288264561	2.795876044	2.732262403	5.316044134	2.0420703025	4.0241532685	2.0420703025	4.0241532685	0.5074534110032	0.231982	0	1.97062425498938	0.232308	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0045171,intercellular bridge;GO:0005634,nucleus;GO:0035686,sperm fibrous sheath	GO:0019899,enzyme binding;GO:0043295,glutathione binding;GO:0004364,glutathione transferase activity;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity	GO:0070458,cellular detoxification of nitrogen compound;GO:0008065,establishment of blood-nerve barrier;GO:1901687,glutathione derivative biosynthetic process;GO:0006749,glutathione metabolic process;GO:0018916,nitrobenzene metabolic process;GO:0043627,response to estrogen;GO:0042178,xenobiotic catabolic process	hsa:2947,path:hsa00480,Glutathione metabolism;hsa:2947,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:2947,path:hsa00982,Drug metabolism - cytochrome P450;hsa:2947,path:hsa00983,Drug metabolism - other enzymes;hsa:2947,path:hsa05200,Pathways in cancer;hsa:2947,path:hsa05204,Chemical carcinogenesis;hsa:2947,path:hsa05225,Hepatocellular carcinoma;hsa:2947,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:2947,path:hsa01524,Platinum drug resistance
EST1_HUMAN	P23141	CES1	Liver carboxylesterase 1	6.054036378	18.411754	11.06010751	31.87960676	12.232895189	21.469857135	12.232895189	21.469857135	0.569770684177401	0.289337	0	1.75509205329463	0.289633	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005788,endoplasmic reticulum lumen;GO:0005615,extracellular space;GO:0005811,lipid droplet	GO:0052689,carboxylic ester hydrolase activity;GO:0080030,methyl indole-3-acetate esterase activity;GO:0047374,methylumbelliferyl-acetate deacetylase activity;GO:0004771,sterol esterase activity;GO:0004806,triglyceride lipase activity	GO:0002003,angiotensin maturation;GO:0071397,cellular response to cholesterol;GO:0071404,cellular response to low-density lipoprotein particle stimulus;GO:0006695,cholesterol biosynthetic process;GO:0090122,cholesterol ester hydrolysis involved in cholesterol transport;GO:0042632,cholesterol homeostasis;GO:0008203,cholesterol metabolic process;GO:0030855,epithelial cell differentiation;GO:0016042,lipid catabolic process;GO:0051791,medium-chain fatty acid metabolic process;GO:0010887,negative regulation of cholesterol storage;GO:0010875,positive regulation of cholesterol efflux;GO:0090205,positive regulation of cholesterol metabolic process;GO:0070857,regulation of bile acid biosynthetic process;GO:0120188,regulation of bile acid secretion;GO:0009636,response to toxic substance;GO:0043691,reverse cholesterol transport;GO:0006805,xenobiotic metabolic process	hsa:1066,path:hsa00983,Drug metabolism - other enzymes
NHRF1_HUMAN	O14745	SLC9A3R1	Na(+)/H(+) exchange regulatory cofactor NHE-RF1	1.273560184	1.525623666	1.427668989	2.468248312	1.399591925	1.9479586505	1.399591925	1.9479586505	0.71849159870039	0.420388	0	1.39180472229432	0.420568	0	GO:0015629,actin cytoskeleton;GO:0016324,apical plasma membrane;GO:0031526,brush border membrane;GO:0071944,cell periphery;GO:0005737,cytoplasm;GO:0012505,endomembrane system;GO:0070062,extracellular exosome;GO:0030175,filopodium;GO:0016020,membrane;GO:0045121,membrane raft;GO:0005902,microvillus;GO:0031528,microvillus membrane;GO:0048471,perinuclear region of cytoplasm;GO:0098797,plasma membrane protein complex;GO:0001726,ruffle;GO:0097225,sperm midpiece;GO:0032426,stereocilium tip;GO:0031982,vesicle	GO:0031698,beta-2 adrenergic receptor binding;GO:0008013,beta-catenin binding;GO:0017081,chloride channel regulator activity;GO:0050780,dopamine receptor binding;GO:0015185,gamma-aminobutyric acid transmembrane transporter activity;GO:0070851,growth factor receptor binding;GO:0045159,myosin II binding;GO:0030165,PDZ domain binding;GO:0019902,phosphatase binding;GO:0047485,protein N-terminus binding;GO:0043621,protein self-association;GO:0044877,protein-containing complex binding;GO:0043495,protein-membrane adaptor activity;GO:0005102,signaling receptor binding;GO:0031799,type 2 metabotropic glutamate receptor binding;GO:0031800,type 3 metabotropic glutamate receptor binding;GO:0060090,molecular adaptor activity	GO:0030036,actin cytoskeleton organization;GO:0007191,adenylate cyclase-activating dopamine receptor signaling pathway;GO:0060088,auditory receptor cell stereocilium organization;GO:0032782,bile acid secretion;GO:0019933,cAMP-mediated signaling;GO:0030643,cellular phosphate ion homeostasis;GO:0090660,cerebrospinal fluid circulation;GO:0044782,cilium organization;GO:0045198,establishment of epithelial cell apical/basal polarity;GO:0051683,establishment of Golgi localization;GO:0051939,gamma-aminobutyric acid import;GO:0022612,gland morphogenesis;GO:0034635,glutathione transport;GO:0098739,import across plasma membrane;GO:0045199,maintenance of epithelial cell apical/basal polarity;GO:0030033,microvillus assembly;GO:0002009,morphogenesis of an epithelium;GO:0090090,negative regulation of canonical Wnt signaling pathway;GO:0030336,negative regulation of cell migration;GO:0008285,negative regulation of cell population proliferation;GO:0070373,negative regulation of ERK1 and ERK2 cascade;GO:0045930,negative regulation of mitotic cell cycle;GO:0014067,negative regulation of phosphatidylinositol 3-kinase signaling;GO:0010642,negative regulation of platelet-derived growth factor receptor signaling pathway;GO:0051898,negative regulation of protein kinase B signaling;GO:0032416,negative regulation of sodium;GO:0007097,nuclear migration;GO:0060158,phospholipase C-activating dopamine receptor signaling pathway;GO:0007009,plasma membrane organization;GO:2001244,positive regulation of intrinsic apoptotic signaling pathway;GO:0034767,positive regulation of ion transmembrane transport;GO:0072659,protein localization to plasma membrane;GO:0065003,protein-containing complex assembly;GO:0008360,regulation of cell shape;GO:0008361,regulation of cell size;GO:0044062,regulation of excretion;GO:0045859,regulation of protein kinase activity;GO:0032415,regulation of sodium;GO:0070293,renal absorption;GO:0097291,renal phosphate ion absorption;GO:0003096,renal sodium ion transport;GO:0007605,sensory perception of sound;GO:0150104,transport across blood-brain barrier;GO:0016055,Wnt signaling pathway	hsa:9368,path:hsa04530,Tight junction;hsa:9368,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:9368,path:hsa05130,Pathogenic Escherichia coli infection;hsa:9368,path:hsa05165,Human papillomavirus infection
MGST1_HUMAN	P10620	MGST1	Microsomal glutathione S-transferase 1	5.74924645	18.46372569	1.770507388	0.359409408	12.10648607	1.064958398	12.10648607	1.064958398	11.3680366225912	0.013322	1	0.0879659375843977	0.013150	-1	GO:0045177,apical part of cell;GO:0035577,azurophil granule membrane;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005778,peroxisomal membrane;GO:0005886,plasma membrane	GO:0043295,glutathione binding;GO:0004602,glutathione peroxidase activity;GO:0004364,glutathione transferase activity;GO:0042802,identical protein binding	GO:0046222,aflatoxin metabolic process;GO:0071449,cellular response to lipid hydroperoxide;GO:1901687,glutathione derivative biosynthetic process;GO:0034635,glutathione transport;GO:0033327,Leydig cell differentiation;GO:0043312,neutrophil degranulation;GO:0042493,response to drug;GO:0032496,response to lipopolysaccharide;GO:0010243,response to organonitrogen compound	hsa:4257,path:hsa00480,Glutathione metabolism;hsa:4257,path:hsa00980,Metabolism of xenobiotics by cytochrome P450;hsa:4257,path:hsa00982,Drug metabolism - cytochrome P450;hsa:4257,path:hsa00983,Drug metabolism - other enzymes;hsa:4257,path:hsa05200,Pathways in cancer;hsa:4257,path:hsa05204,Chemical carcinogenesis;hsa:4257,path:hsa05225,Hepatocellular carcinoma;hsa:4257,path:hsa05418,Fluid shear stress and atherosclerosis;hsa:4257,path:hsa01524,Platinum drug resistance
NECP2_HUMAN	Q9NVZ3	NECAP2	Adaptin ear-binding coat-associated protein 2	0.192974138	0.280954739	0.303262867	0.110357368	0.2369644385	0.2068101175	0.2369644385	0.2068101175	1.145806797871	0.388753	0	0.872747484006973	0.388463	0	GO:0030125,clathrin vesicle coat;GO:0005905,clathrin-coated pit;GO:0030665,clathrin-coated vesicle membrane		GO:0006897,endocytosis;GO:0015031,protein transport;GO:0016192,vesicle-mediated transport	
CARL1_HUMAN	Q5VZK9	CARMIL1	F-actin-uncapping protein LRRC16A	0.01842864	0.019991948	2.55E-05	0.048409573	0.019210294	0.0242175365	0.019210294	0.0242175365	0.793238982007935	0.480200	0	1.26065413158174	0.480313	0	GO:0031252,cell leading edge;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0031941,filamentous actin;GO:0030027,lamellipodium;GO:0044354,macropinosome;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005886,plasma membrane	GO:0044877,protein-containing complex binding	GO:0051639,actin filament network formation;GO:0007015,actin filament organization;GO:0051638,barbed-end actin filament uncapping;GO:0007596,blood coagulation;GO:0016477,cell migration;GO:0030032,lamellipodium assembly;GO:0044351,macropinocytosis;GO:2000813,negative regulation of barbed-end actin filament capping;GO:0030838,positive regulation of actin filament polymerization;GO:0030335,positive regulation of cell migration;GO:1902745,positive regulation of lamellipodium organization;GO:0051496,positive regulation of stress fiber assembly;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0031529,ruffle organization;GO:0046415,urate metabolic process	
SPS2L_HUMAN	Q9NUQ6	SPATS2L	SPATS2-like protein	0.050916467	0.027889094	0.101459112	2.55E-05	0.0394027805	0.050742306	0.0394027805	0.050742306	0.776527194093229	0.467247	0	1.28778490644842	0.467375	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0032991,protein-containing complex	GO:0003723,RNA binding		
THIM_HUMAN	P42765	ACAA2	3-ketoacyl-CoA thiolase, mitochondrial	5.668390734	6.229973458	8.590563691	7.616084032	5.949182096	8.1033238615	5.949182096	8.1033238615	0.734165658152376	0.433323	0	1.36209040683901	0.433488	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0003985,acetyl-CoA C-acetyltransferase activity;GO:0003988,acetyl-CoA C-acyltransferase activity;GO:0003986,acetyl-CoA hydrolase activity;GO:0047617,acyl-CoA hydrolase activity;GO:0102991,myristoyl-CoA hydrolase activity;GO:0016290,palmitoyl-CoA hydrolase activity;GO:0003723,RNA binding;GO:0016747,transferase activity, transferring acyl groups other than amino-acyl groups	GO:0071456,cellular response to hypoxia;GO:0006695,cholesterol biosynthetic process;GO:0006635,fatty acid beta-oxidation;GO:1902109,negative regulation of mitochondrial membrane permeability involved in apoptotic process;GO:1901029,negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	hsa:10449,path:hsa00062,Fatty acid elongation;hsa:10449,path:hsa00071,Fatty acid degradation;hsa:10449,path:hsa00280,Valine, leucine and isoleucine degradation
SODC_HUMAN	P00441	SOD1	Superoxide dismutase [Cu-Zn]	12.34539062	15.22499744	1.493616912	0.447048397	13.78519403	0.9703326545	13.78519403	0.9703326545	14.2066681627893	0.008096	1	0.0703894810902419	0.007975	-1	GO:1904115,axon cytoplasm;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0032839,dendrite cytoplasm;GO:0031045,dense core granule;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005764,lysosome;GO:0005758,mitochondrial intermembrane space;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0043025,neuronal cell body;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005777,peroxisome;GO:0032991,protein-containing complex	GO:0051087,chaperone binding;GO:0005507,copper ion binding;GO:0042802,identical protein binding;GO:0030346,protein phosphatase 2B binding;GO:0031267,small GTPase binding;GO:0004784,superoxide dismutase activity;GO:0008270,zinc ion binding;GO:0046872,metal ion binding	GO:0000187,activation of MAPK activity;GO:0008089,anterograde axonal transport;GO:0060088,auditory receptor cell stereocilium organization;GO:0007569,cell aging;GO:0006879,cellular iron ion homeostasis;GO:0071318,cellular response to ATP;GO:0071276,cellular response to cadmium ion;GO:0034599,cellular response to oxidative stress;GO:0035865,cellular response to potassium ion;GO:0007566,embryo implantation;GO:0006749,glutathione metabolic process;GO:0060047,heart contraction;GO:0050665,hydrogen peroxide biosynthetic process;GO:0035722,interleukin-12-mediated signaling pathway;GO:0007626,locomotory behavior;GO:0046716,muscle cell cellular homeostasis;GO:0002262,myeloid cell homeostasis;GO:0045541,negative regulation of cholesterol biosynthetic process;GO:0050728,negative regulation of inflammatory response;GO:0043524,negative regulation of neuron apoptotic process;GO:0060052,neurofilament cytoskeleton organization;GO:0001541,ovarian follicle development;GO:0032287,peripheral nervous system myelin maintenance;GO:0001890,placenta development;GO:0002576,platelet degranulation;GO:0043065,positive regulation of apoptotic process;GO:0043085,positive regulation of catalytic activity;GO:0001819,positive regulation of cytokine production;GO:1902177,positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:0050766,positive regulation of phagocytosis;GO:0032930,positive regulation of superoxide anion generation;GO:0072593,reactive oxygen species metabolic process;GO:0008217,regulation of blood pressure;GO:0043087,regulation of GTPase activity;GO:0051881,regulation of mitochondrial membrane potential;GO:0040014,regulation of multicellular organism growth;GO:0046620,regulation of organ growth;GO:0045859,regulation of protein kinase activity;GO:0033081,regulation of T cell differentiation in thymus;GO:0060087,relaxation of vascular associated smooth muscle;GO:0019430,removal of superoxide radicals;GO:0001975,response to amphetamine;GO:0046677,response to antibiotic;GO:0097332,response to antipsychotic drug;GO:0048678,response to axon injury;GO:0034465,response to carbon monoxide;GO:0046688,response to copper ion;GO:0042493,response to drug;GO:0045471,response to ethanol;GO:0009408,response to heat;GO:0042542,response to hydrogen peroxide;GO:0031667,response to nutrient levels;GO:0010033,response to organic substance;GO:0000303,response to superoxide;GO:0001895,retina homeostasis;GO:0008090,retrograde axonal transport;GO:0007605,sensory perception of sound;GO:0007283,spermatogenesis;GO:0042554,superoxide anion generation;GO:0006801,superoxide metabolic process;GO:0048538,thymus development;GO:0019226,transmission of nerve impulse	hsa:6647,path:hsa04146,Peroxisome;hsa:6647,path:hsa04213,Longevity regulating pathway - multiple species;hsa:6647,path:hsa05014,Amyotrophic lateral sclerosis (ALS);hsa:6647,path:hsa05016,Huntington disease;hsa:6647,path:hsa05020,Prion diseases
KVD11_HUMAN	A0A0A0MRZ8	IGKV3D-11	Immunoglobulin kappa variable 3D-11	6.46886191	4.390527952	5.380199103	4.702850882	5.429694931	5.0415249925	5.429694931	5.0415249925	1.07699454809357	0.408903	0	0.928509807008898	0.408654	0	GO:0005615,extracellular space;GO:0019814,immunoglobulin complex;GO:0005886,plasma membrane;GO:0005576,extracellular region		GO:0002250,adaptive immune response;GO:0006955,immune response;GO:0006956,complement activation;GO:0006958,complement activation, classical pathway;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0050900,leukocyte migration;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0008228,opsonization;GO:0018149,peptide cross-linking;GO:0006898,receptor-mediated endocytosis;GO:0030449,regulation of complement activation;GO:0050776,regulation of immune response	
UCHL5_HUMAN	Q9Y5K5	UCHL5	Ubiquitin carboxyl-terminal hydrolase isozyme L5	1.718380071	0.577203728	1.612874928	0.592799956	1.1477918995	1.102837442	1.1477918995	1.102837442	1.04076254195584	0.420144	0	0.960833965181682	0.419919	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0031011,Ino80 complex;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0000502,proteasome complex;GO:0031597,cytosolic proteasome complex	GO:0004866,endopeptidase inhibitor activity;GO:0070628,proteasome binding;GO:0003723,RNA binding;GO:0004843,thiol-dependent deubiquitinase	GO:0006310,DNA recombination;GO:0006281,DNA repair;GO:0032435,negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0045880,positive regulation of smoothened signaling pathway;GO:0016579,protein deubiquitination;GO:0061136,regulation of proteasomal protein catabolic process;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0048853,forebrain morphogenesis;GO:0021670,lateral ventricle development;GO:0030901,midbrain development	
MFN1_HUMAN	Q8IWA4	MFN1	Mitofusin-1	0.173781285	0.071721786	0.26153797	0.298374948	0.1227515355	0.279956459	0.1227515355	0.279956459	0.438466524181891	0.169627	0	2.28067582095541	0.169962	0	GO:0016021,integral component of membrane;GO:0031307,integral component of mitochondrial outer membrane;GO:0031306,intrinsic component of mitochondrial outer membrane;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0098799,outer mitochondrial membrane protein complex	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0042802,identical protein binding	GO:0046039,GTP metabolic process;GO:0016236,macroautophagy;GO:0008053,mitochondrial fusion;GO:1990613,mitochondrial membrane fusion;GO:0051646,mitochondrion localization;GO:0010918,positive regulation of mitochondrial membrane potential	hsa:55669,path:hsa04137,Mitophagy - animal;hsa:55669,path:hsa04621,NOD-like receptor signaling pathway
TIGAR_HUMAN	Q9NQ88	TIGAR	Fructose-2,6-bisphosphatase TIGAR	0.327826108	0.342183731	0.41202105	0.071390651	0.3350049195	0.2417058505	0.3350049195	0.2417058505	1.38600252665378	0.328890	0	0.721499406219914	0.328487	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005741,mitochondrial outer membrane;GO:0005634,nucleus	GO:0004083,bisphosphoglycerate 2-phosphatase activity;GO:0004331,fructose-2,6-bisphosphate 2-phosphatase activity	GO:0006915,apoptotic process;GO:0006914,autophagy;GO:0071279,cellular response to cobalt ion;GO:0006974,cellular response to DNA damage stimulus;GO:0071456,cellular response to hypoxia;GO:0030388,fructose 1,6-bisphosphate metabolic process;GO:0006003,fructose 2,6-bisphosphate metabolic process;GO:0060576,intestinal epithelial cell development;GO:1904024,negative regulation of glucose catabolic process to lactate via pyruvate;GO:0045820,negative regulation of glycolytic process;GO:1901525,negative regulation of mitophagy;GO:1901215,negative regulation of neuron death;GO:0043069,negative regulation of programmed cell death;GO:2000378,negative regulation of reactive oxygen species metabolic process;GO:0010666,positive regulation of cardiac muscle cell apoptotic process;GO:0045739,positive regulation of DNA repair;GO:1903301,positive regulation of hexokinase activity;GO:0043456,regulation of pentose-phosphate shunt;GO:1902153,regulation of response to DNA damage checkpoint signaling;GO:0010332,response to gamma radiation;GO:0002931,response to ischemia;GO:0009410,response to xenobiotic stimulus	hsa:57103,path:hsa00051,Fructose and mannose metabolism;hsa:57103,path:hsa05230,Central carbon metabolism in cancer
MGN_HUMAN	P61326	MAGOH	Protein mago nashi homolog	6.100923441	5.165216391	0.501835483	0.05675473	5.633069916	0.2792951065	5.633069916	0.2792951065	20.1688815339126	0.003468	1	0.049581331434694	0.003404	-1	GO:0071013,catalytic step 2 spliceosome;GO:0005737,cytoplasm;GO:0035145,exon-exon junction complex;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0003723,RNA binding	GO:0031124,mRNA 3'-end processing;GO:0006406,mRNA export from nucleus;GO:0000398,mRNA splicing, via spliceosome;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000381,regulation of alternative mRNA splicing, via spliceosome;GO:0006417,regulation of translation;GO:0006405,RNA export from nucleus;GO:0008380,RNA splicing	hsa:4116,path:hsa03040,Spliceosome;hsa:4116,path:hsa03013,RNA transport;hsa:4116,path:hsa03015,mRNA surveillance pathway
SRP09_HUMAN	P49458	SRP9	Signal recognition particle 9 kDa protein	0.149084097	0.103714776	0.170889186	0.09525637	0.1263994365	0.133072778	0.1263994365	0.133072778	0.949851941168614	0.450466	0	1.05279565862622	0.450306	0	GO:0005829,cytosol;GO:0005785,signal recognition particle receptor complex;GO:0005786,signal recognition particle, endoplasmic reticulum targeting	GO:0008312,7S RNA binding;GO:0003723,RNA binding;GO:0005047,signal recognition particle binding	GO:0045900,negative regulation of translational elongation;GO:0006614,SRP-dependent cotranslational protein targeting to membrane	hsa:6726,path:hsa03060,Protein export
EGFR_HUMAN	P00533	EGFR	Epidermal growth factor receptor	0.403912709	0.268682912	0.492949649	0.476083025	0.3362978105	0.484516337	0.3362978105	0.484516337	0.694089723748572	0.399862	0	1.4407359247437	0.400063	0	GO:0016324,apical plasma membrane;GO:0009925,basal plasma membrane;GO:0016323,basolateral plasma membrane;GO:0030054,cell junction;GO:0009986,cell surface;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0005737,cytoplasm;GO:0031901,early endosome membrane;GO:0005789,endoplasmic reticulum membrane;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0005615,extracellular space;GO:0005925,focal adhesion;GO:0000139,Golgi membrane;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0045121,membrane raft;GO:0097489,multivesicular body, internal vesicle lumen;GO:0031965,nuclear membrane;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0043235,receptor complex;GO:0070435,Shc-EGFR complex;GO:0045202,synapse;GO:0016021,integral component of membrane	GO:0051015,actin filament binding;GO:0005524,ATP binding;GO:0051117,ATPase binding;GO:0045296,cadherin binding;GO:0005516,calmodulin binding;GO:0003682,chromatin binding;GO:0003690,double-stranded DNA binding;GO:0019899,enzyme binding;GO:0048408,epidermal growth factor binding;GO:0005006,epidermal growth factor-activated receptor activity;GO:0042802,identical protein binding;GO:0005178,integrin binding;GO:0019900,kinase binding;GO:0004709,MAP kinase kinase kinase activity;GO:0019901,protein kinase binding;GO:0019903,protein phosphatase binding;GO:0004713,protein tyrosine kinase activity;GO:0004714,transmembrane receptor protein tyrosine kinase activity;GO:0004888,transmembrane signaling receptor activity;GO:0031625,ubiquitin protein ligase binding;GO:0001618,virus receptor activity	GO:0043006,activation of phospholipase A2 activity by calcium-mediated signaling;GO:0007202,activation of phospholipase C activity;GO:0048143,astrocyte activation;GO:0030154,cell differentiation;GO:0007166,cell surface receptor signaling pathway;GO:0098609,cell-cell adhesion;GO:0071276,cellular response to cadmium ion;GO:0071549,cellular response to dexamethasone stimulus;GO:0035690,cellular response to drug;GO:0071364,cellular response to epidermal growth factor stimulus;GO:0071392,cellular response to estradiol stimulus;GO:0071260,cellular response to mechanical stimulus;GO:0034614,cellular response to reactive oxygen species;GO:0007623,circadian rhythm;GO:0016101,diterpenoid metabolic process;GO:0007173,epidermal growth factor receptor signaling pathway;GO:0038128,ERBB2 signaling pathway;GO:0001942,hair follicle development;GO:0042743,hydrogen peroxide metabolic process;GO:0007611,learning or memory;GO:0097421,liver regeneration;GO:0030324,lung development;GO:0010960,magnesium ion homeostasis;GO:0000165,MAPK cascade;GO:0061024,membrane organization;GO:0007494,midgut development;GO:0007275,multicellular organism development;GO:0043066,negative regulation of apoptotic process;GO:1905208,negative regulation of cardiocyte differentiation;GO:0042059,negative regulation of epidermal growth factor receptor signaling pathway;GO:1901185,negative regulation of ERBB signaling pathway;GO:0045930,negative regulation of mitotic cell cycle;GO:0045746,negative regulation of Notch signaling pathway;GO:0042177,negative regulation of protein catabolic process;GO:0048812,neuron projection morphogenesis;GO:0001503,ossification;GO:0042698,ovulation cycle;GO:0038083,peptidyl-tyrosine autophosphorylation;GO:0018108,peptidyl-tyrosine phosphorylation;GO:0045780,positive regulation of bone resorption;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0030307,positive regulation of cell growth;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0045737,positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045739,positive regulation of DNA repair;GO:0045740,positive regulation of DNA replication;GO:0050679,positive regulation of epithelial cell proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:1900087,positive regulation of G1/S transition of mitotic cell cycle;GO:0060252,positive regulation of glial cell proliferation;GO:0050729,positive regulation of inflammatory response;GO:0033674,positive regulation of kinase activity;GO:0043406,positive regulation of MAP kinase activity;GO:0070257,positive regulation of mucus secretion;GO:1901224,positive regulation of NIK/NF-kappaB signaling;GO:0010750,positive regulation of nitric oxide mediated signal transduction;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0042327,positive regulation of phosphorylation;GO:1903800,positive regulation of production of miRNAs involved in gene silencing by miRNA;GO:1902722,positive regulation of prolactin secretion;GO:0051897,positive regulation of protein kinase B signaling;GO:1900020,positive regulation of protein kinase C activity;GO:1903078,positive regulation of protein localization to plasma membrane;GO:0001934,positive regulation of protein phosphorylation;GO:0048661,positive regulation of smooth muscle cell proliferation;GO:0032930,positive regulation of superoxide anion generation;GO:0051968,positive regulation of synaptic transmission, glutamatergic;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0045893,positive regulation of transcription, DNA-templated;GO:0045907,positive regulation of vasoconstriction;GO:0046777,protein autophosphorylation;GO:0051205,protein insertion into membrane;GO:2000145,regulation of cell motility;GO:0070372,regulation of ERK1 and ERK2 cascade;GO:0046328,regulation of JNK cascade;GO:0050999,regulation of nitric-oxide synthase activity;GO:0050730,regulation of peptidyl-tyrosine phosphorylation;GO:0014066,regulation of phosphatidylinositol 3-kinase signaling;GO:0006357,regulation of transcription by RNA polymerase II;GO:0051592,response to calcium ion;GO:0033590,response to cobalamin;GO:0033594,response to hydroxyisoflavone;GO:0006970,response to osmotic stress;GO:0070141,response to UV-A;GO:0007165,signal transduction;GO:0043586,tongue development;GO:0006412,translation;GO:0007169,transmembrane receptor protein tyrosine kinase signaling pathway;GO:0046718,viral entry into host cell;GO:0019058,viral life cycle;GO:0042060,wound healing;GO:0006898,receptor-mediated endocytosis	hsa:1956,path:hsa04014,Ras signaling pathway;hsa:1956,path:hsa04015,Rap1 signaling pathway;hsa:1956,path:hsa04010,MAPK signaling pathway;hsa:1956,path:hsa04012,ErbB signaling pathway;hsa:1956,path:hsa04630,Jak-STAT signaling pathway;hsa:1956,path:hsa04066,HIF-1 signaling pathway;hsa:1956,path:hsa04068,FoxO signaling pathway;hsa:1956,path:hsa04020,Calcium signaling pathway;hsa:1956,path:hsa04072,Phospholipase D signaling pathway;hsa:1956,path:hsa04151,PI3K-Akt signaling pathway;hsa:1956,path:hsa04144,Endocytosis;hsa:1956,path:hsa04510,Focal adhesion;hsa:1956,path:hsa04520,Adherens junction;hsa:1956,path:hsa04540,Gap junction;hsa:1956,path:hsa04810,Regulation of actin cytoskeleton;hsa:1956,path:hsa04912,GnRH signaling pathway;hsa:1956,path:hsa04915,Estrogen signaling pathway;hsa:1956,path:hsa04921,Oxytocin signaling pathway;hsa:1956,path:hsa04926,Relaxin signaling pathway;hsa:1956,path:hsa04928,Parathyroid hormone synthesis, secretion and action;hsa:1956,path:hsa05200,Pathways in cancer;hsa:1956,path:hsa05206,MicroRNAs in cancer;hsa:1956,path:hsa05205,Proteoglycans in cancer;hsa:1956,path:hsa05230,Central carbon metabolism in cancer;hsa:1956,path:hsa05231,Choline metabolism in cancer;hsa:1956,path:hsa05235,PD-L1 expression and PD-1 checkpoint pathway in cancer;hsa:1956,path:hsa05210,Colorectal cancer;hsa:1956,path:hsa05212,Pancreatic cancer;hsa:1956,path:hsa05225,Hepatocellular carcinoma;hsa:1956,path:hsa05226,Gastric cancer;hsa:1956,path:hsa05214,Glioma;hsa:1956,path:hsa05218,Melanoma;hsa:1956,path:hsa05219,Bladder cancer;hsa:1956,path:hsa05215,Prostate cancer;hsa:1956,path:hsa05213,Endometrial cancer;hsa:1956,path:hsa05224,Breast cancer;hsa:1956,path:hsa05223,Non-small cell lung cancer;hsa:1956,path:hsa04934,Cushing syndrome;hsa:1956,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:1956,path:hsa05131,Shigellosis;hsa:1956,path:hsa05160,Hepatitis C;hsa:1956,path:hsa05163,Human cytomegalovirus infection;hsa:1956,path:hsa05165,Human papillomavirus infection;hsa:1956,path:hsa01521,EGFR tyrosine kinase inhibitor resistance;hsa:1956,path:hsa01522,Endocrine resistance
DDX27_HUMAN	Q96GQ7	DDX27	Probable ATP-dependent RNA helicase DDX27	0.884753785	0.416924292	1.038293161	3.619680628	0.6508390385	2.3289868945	0.6508390385	2.3289868945	0.279451567562267	0.050085	0	3.57843761165227	0.050304	0	GO:0005694,chromosome;GO:0005730,nucleolus	GO:0005524,ATP binding;GO:0016787,hydrolase activity;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0003676,nucleic acid binding	GO:0006364,rRNA processing	
ADPGK_HUMAN	Q9BRR6	ADPGK	ADP-dependent glucokinase	0.275135989	0.351045855	0.624205924	0.587886371	0.313090922	0.6060461475	0.313090922	0.6060461475	0.516612345927007	0.240405	0	1.93568738316852	0.240728	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005576,extracellular region;GO:0016020,membrane;GO:0016021,integral component of membrane	GO:0043843,ADP-specific glucokinase activity;GO:0046872,metal ion binding;GO:0016773,phosphotransferase activity, alcohol group as acceptor;GO:0016301,kinase activity	GO:0006006,glucose metabolic process;GO:0061620,glycolytic process through glucose-6-phosphate;GO:0006096,glycolytic process	hsa:83440,path:hsa00010,Glycolysis / Gluconeogenesis
RS6_HUMAN	P62753	RPS6	40S ribosomal protein S6	3.550036	6.137090076	1.420170118	0.944894844	4.843563038	1.182532481	4.843563038	1.182532481	4.09592388862256	0.087505	0	0.244145161675916	0.087005	0	GO:0044297,cell body;GO:0036464,cytoplasmic ribonucleoprotein granule;GO:0005829,cytosol;GO:0022626,cytosolic ribosome;GO:0022627,cytosolic small ribosomal subunit;GO:0030425,dendrite;GO:0005783,endoplasmic reticulum;GO:0016020,membrane;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005844,polysome;GO:1990904,ribonucleoprotein complex;GO:0015935,small ribosomal subunit;GO:0005840,ribosome	GO:0019901,protein kinase binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0006924,activation-induced cell death of T cells;GO:0002181,cytoplasmic translation;GO:0048821,erythrocyte development;GO:0000082,G1/S transition of mitotic cell cycle;GO:0007369,gastrulation;GO:0042593,glucose homeostasis;GO:0022605,mammalian oogenesis stage;GO:0043066,negative regulation of apoptotic process;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0001890,placenta development;GO:0043065,positive regulation of apoptotic process;GO:0008284,positive regulation of cell population proliferation;GO:0042274,ribosomal small subunit biogenesis;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0033077,T cell differentiation in thymus;GO:0002309,T cell proliferation involved in immune response;GO:0031929,TOR signaling;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6194,path:hsa03010,Ribosome;hsa:6194,path:hsa04371,Apelin signaling pathway;hsa:6194,path:hsa04066,HIF-1 signaling pathway;hsa:6194,path:hsa04151,PI3K-Akt signaling pathway;hsa:6194,path:hsa04150,mTOR signaling pathway;hsa:6194,path:hsa04910,Insulin signaling pathway;hsa:6194,path:hsa04714,Thermogenesis;hsa:6194,path:hsa05205,Proteoglycans in cancer;hsa:6194,path:hsa01521,EGFR tyrosine kinase inhibitor resistance
UBQL2_HUMAN	Q9UHD9	UBQLN2	Ubiquilin-2	2.55E-05	0.012616335	2.55E-05	0.057633783	0.0063209175	0.0288296415	0.0063209175	0.0288296415	0.219250645208335	0.021963	-1	4.56098999868294	0.022096	1	GO:0005776,autophagosome;GO:0005737,cytoplasm;GO:0031410,cytoplasmic vesicle;GO:0005829,cytosol;GO:0005634,nucleus;GO:0005886,plasma membrane	GO:0042802,identical protein binding;GO:0031593,polyubiquitin modification-dependent protein binding	GO:0000045,autophagosome assembly;GO:1900186,negative regulation of clathrin-dependent endocytosis;GO:1904021,negative regulation of G protein-coupled receptor internalization;GO:1903071,positive regulation of ER-associated ubiquitin-dependent protein catabolic process;GO:2000785,regulation of autophagosome assembly;GO:0016241,regulation of macroautophagy;GO:0030433,ubiquitin-dependent ERAD pathway;GO:0006511,ubiquitin-dependent protein catabolic process	hsa:29978,path:hsa04141,Protein processing in endoplasmic reticulum
CNOT1_HUMAN	A5YKK6	CNOT1	CCR4-NOT transcription complex subunit 1	0.802855556	0.684032048	0.820776018	1.441380896	0.743443802	1.131078457	0.743443802	1.131078457	0.657287562501953	0.368073	0	1.52140411145697	0.368305	0	GO:0030014,CCR4-NOT complex;GO:0030015,CCR4-NOT core complex;GO:0005829,cytosol;GO:0005615,extracellular space;GO:0016020,membrane;GO:0005634,nucleus;GO:0000932,P-body;GO:0005778,peroxisomal membrane	GO:0070016,armadillo repeat domain binding;GO:0030331,estrogen receptor binding;GO:0060090,molecular adaptor activity;GO:0019904,protein domain specific binding;GO:0042974,retinoic acid receptor binding;GO:0003723,RNA binding	GO:0006977,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0035195,gene silencing by miRNA;GO:0033147,negative regulation of intracellular estrogen receptor signaling pathway;GO:0048387,negative regulation of retinoic acid receptor signaling pathway;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0017148,negative regulation of translation;GO:0000288,nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0000289,nuclear-transcribed mRNA poly(A) tail shortening;GO:0010606,positive regulation of cytoplasmic mRNA processing body assembly;GO:0061014,positive regulation of mRNA catabolic process;GO:1900153,positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0060213,positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:2000036,regulation of stem cell population maintenance;GO:0090503,RNA phosphodiester bond hydrolysis, exonucleolytic;GO:0001829,trophectodermal cell differentiation;GO:0006417,regulation of translation	hsa:23019,path:hsa03018,RNA degradation
OCAD1_HUMAN	Q9NX40	OCIAD1	OCIA domain-containing protein 1	0.421849624	0.406359575	0.568770073	0.487944294	0.4141045995	0.5283571835	0.4141045995	0.5283571835	0.783758813984214	0.472883	0	1.27590271669996	0.473004	0	GO:0005768,endosome;GO:0005794,Golgi apparatus;GO:0005764,lysosome;GO:0016020,membrane		GO:0006897,endocytosis;GO:0061484,hematopoietic stem cell homeostasis;GO:0046427,positive regulation of receptor signaling pathway via JAK-STAT;GO:2000736,regulation of stem cell differentiation	
SF3B1_HUMAN	O75533	SF3B1	Splicing factor 3B subunit 1	3.352790219	2.049005642	5.192978489	5.111842994	2.7008979305	5.1524107415	2.7008979305	5.1524107415	0.524200818996371	0.247394	0	1.90766584820411	0.247713	0	GO:0071013,catalytic step 2 spliceosome;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0005681,spliceosomal complex;GO:0034693,U11/U12 snRNP;GO:0005689,U12-type spliceosomal complex;GO:0005686,U2 snRNP;GO:0071005,U2-type precatalytic spliceosome;GO:0071004,U2-type prespliceosome	GO:0003729,mRNA binding;GO:0003723,RNA binding;GO:1990935,splicing factor binding	GO:0000398,mRNA splicing, via spliceosome;GO:0045815,positive regulation of gene expression, epigenetic;GO:0008380,RNA splicing;GO:0000375,RNA splicing, via transesterification reactions;GO:0000245,spliceosomal complex assembly	hsa:23451,path:hsa03040,Spliceosome
OSB11_HUMAN	Q9BXB4	OSBPL11	Oxysterol-binding protein-related protein 11	0.081212939	0.140991386	0.194736091	0.177089173	0.1111021625	0.185912632	0.1111021625	0.185912632	0.597604161184701	0.314748	0	1.67334845530122	0.315026	0	GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0031902,late endosome membrane;GO:0016020,membrane;GO:0005654,nucleoplasm	GO:0032934,sterol binding;GO:0015248,sterol transporter activity	GO:0045444,fat cell differentiation;GO:0010890,positive regulation of sequestering of triglyceride	
ACDSB_HUMAN	P45954	ACADSB	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	1.729090468	2.028405768	3.784755202	2.013231234	1.878748118	2.898993218	1.878748118	2.898993218	0.648069166334973	0.359968	0	1.5430451747231	0.360207	0	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion	GO:0003853,2-methylacyl-CoA dehydrogenase activity;GO:0050660,flavin adenine dinucleotide binding;GO:0042802,identical protein binding;GO:0102035,isobutyryl-CoA;GO:0016937,short-branched-chain-acyl-CoA dehydrogenase activity	GO:0009083,branched-chain amino acid catabolic process;GO:0006631,fatty acid metabolic process;GO:0006550,isoleucine catabolic process	hsa:36,path:hsa00071,Fatty acid degradation;hsa:36,path:hsa00280,Valine, leucine and isoleucine degradation
GPD1L_HUMAN	Q8N335	GPD1L	Glycerol-3-phosphate dehydrogenase 1-like protein	0.938872472	0.840649198	1.397583337	2.274053927	0.889760835	1.835818632	0.889760835	1.835818632	0.484667068680236	0.211119	0	2.06327201623794	0.211451	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0009331,glycerol-3-phosphate dehydrogenase complex;GO:0005886,plasma membrane	GO:0044325,ion channel binding;GO:0051287,NAD binding;GO:0016616,oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0042803,protein homodimerization activity;GO:0017080,sodium channel regulator activity;GO:0004367,glycerol-3-phosphate dehydrogenase [NAD+] activity	GO:0005975,carbohydrate metabolic process;GO:0046168,glycerol-3-phosphate catabolic process;GO:0019674,NAD metabolic process;GO:0006734,NADH metabolic process;GO:0033137,negative regulation of peptidyl-serine phosphorylation;GO:0090038,negative regulation of protein kinase C signaling;GO:0006654,phosphatidic acid biosynthetic process;GO:2000010,positive regulation of protein localization to cell surface;GO:0010765,positive regulation of sodium ion transport;GO:0002027,regulation of heart rate;GO:2000649,regulation of sodium ion transmembrane transporter activity;GO:0060373,regulation of ventricular cardiac muscle cell membrane depolarization;GO:0086005,ventricular cardiac muscle cell action potential	hsa:23171,path:hsa00564,Glycerophospholipid metabolism
IDE_HUMAN	P14735	IDE	Insulin-degrading enzyme	0.805737837	0.580335601	1.069808233	0.559288853	0.693036719	0.814548543	0.693036719	0.814548543	0.850823103123518	0.487362	0	1.17533244728408	0.487284	0	GO:0016323,basolateral plasma membrane;GO:0009986,cell surface;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0031597,cytosolic proteasome complex;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005782,peroxisomal matrix;GO:0005777,peroxisome	GO:0001540,amyloid-beta binding;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0031626,beta-endorphin binding;GO:0004175,endopeptidase activity;GO:0042802,identical protein binding;GO:0043559,insulin binding;GO:0004222,metalloendopeptidase activity;GO:0042277,peptide binding;GO:0042803,protein homodimerization activity;GO:0044877,protein-containing complex binding;GO:0140036,ubiquitin-dependent protein binding;GO:0001618,virus receptor activity;GO:0008270,zinc ion binding;GO:0046872,metal ion binding;GO:0008237,metallopeptidase activity	GO:0097242,amyloid-beta clearance;GO:0150094,amyloid-beta clearance by cellular catabolic process;GO:0050435,amyloid-beta metabolic process;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0010815,bradykinin catabolic process;GO:0044257,cellular protein catabolic process;GO:0008340,determination of adult lifespan;GO:0042447,hormone catabolic process;GO:1901143,insulin catabolic process;GO:1901142,insulin metabolic process;GO:0008286,insulin receptor signaling pathway;GO:0045861,negative regulation of proteolysis;GO:0043171,peptide catabolic process;GO:0032092,positive regulation of protein binding;GO:0045732,positive regulation of protein catabolic process;GO:0030163,protein catabolic process;GO:0008104,protein localization;GO:0006508,proteolysis;GO:0051603,proteolysis involved in cellular protein catabolic process;GO:1903715,regulation of aerobic respiration;GO:0010992,ubiquitin recycling	hsa:3416,path:hsa05010,Alzheimer disease
DHX36_HUMAN	Q9H2U1	DHX36	ATP-dependent DNA/RNA helicase DHX36	0.182411003	0.115638819	0.310680112	0.748204519	0.149024911	0.5294423155	0.149024911	0.5294423155	0.281475255447352	0.051234	0	3.55271016065227	0.051456	0	GO:0030424,axon;GO:0000781,chromosome, telomeric region;GO:0005737,cytoplasm;GO:0010494,cytoplasmic stress granule;GO:0005829,cytosol;GO:0030425,dendrite;GO:0070062,extracellular exosome;GO:0005739,mitochondrion;GO:0016607,nuclear speck;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0043204,perikaryon;GO:0016021,integral component of membrane	GO:0005524,ATP binding;GO:0008094,ATPase activity, acting on DNA;GO:0003678,DNA helicase activity;GO:0003725,double-stranded RNA binding;GO:0051880,G-quadruplex DNA binding;GO:0002151,G-quadruplex RNA binding;GO:0042826,histone deacetylase binding;GO:0000287,magnesium ion binding;GO:0035925,mRNA 3'-UTR AU-rich region binding;GO:0003730,mRNA 3'-UTR binding;GO:0048027,mRNA 5'-UTR binding;GO:0070883,pre-miRNA binding;GO:0003723,RNA binding;GO:0003724,RNA helicase activity;GO:0000978,RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003697,single-stranded DNA binding;GO:0070034,telomerase RNA binding;GO:0000976,transcription regulatory region sequence-specific DNA binding;GO:0016787,hydrolase activity;GO:0003676,nucleic acid binding;GO:0004386,helicase activity	GO:0061158,3'-UTR-mediated mRNA destabilization;GO:1903843,cellular response to arsenite ion;GO:0034605,cellular response to heat;GO:0034644,cellular response to UV;GO:0051607,defense response to virus;GO:0044806,G-quadruplex DNA unwinding;GO:0045087,innate immune response;GO:0017148,negative regulation of translation;GO:0001503,ossification;GO:0051891,positive regulation of cardioblast differentiation;GO:2000767,positive regulation of cytoplasmic translation;GO:0061003,positive regulation of dendritic spine morphogenesis;GO:0010628,positive regulation of gene expression;GO:1901534,positive regulation of hematopoietic progenitor cell differentiation;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0032727,positive regulation of interferon-alpha production;GO:1904582,positive regulation of intracellular mRNA localization;GO:0031442,positive regulation of mRNA 3'-end processing;GO:0002735,positive regulation of myeloid dendritic cell cytokine production;GO:1900153,positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0032206,positive regulation of telomere maintenance;GO:1904358,positive regulation of telomere maintenance via telomere lengthening;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0060261,positive regulation of transcription initiation from RNA polymerase II promoter;GO:0032481,positive regulation of type I interferon production;GO:0045995,regulation of embryonic development;GO:0043488,regulation of mRNA stability;GO:0006359,regulation of transcription by RNA polymerase III;GO:1902064,regulation of transcription from RNA polymerase II promoter involved in spermatogenesis;GO:0043330,response to exogenous dsRNA;GO:0010501,RNA secondary structure unwinding;GO:0007283,spermatogenesis;GO:0090669,telomerase RNA stabilization	hsa:170506,path:hsa03018,RNA degradation
ELOC_HUMAN	Q15369	ELOC	Elongin-C	0.917818498	0.673376149	0.498250489	0.40186449	0.7955973235	0.4500574895	0.7955973235	0.4500574895	1.76776821197639	0.258479	0	0.565685022066317	0.257970	0	GO:0031462,Cul2-RING ubiquitin ligase complex;GO:0005829,cytosol;GO:0070449,elongin complex;GO:0005654,nucleoplasm;GO:0030891,VCB complex	GO:0044877,protein-containing complex binding	GO:0032968,positive regulation of transcription elongation from RNA polymerase II promoter;GO:0043687,post-translational protein modification;GO:0016567,protein ubiquitination;GO:0006357,regulation of transcription by RNA polymerase II;GO:0061418,regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0006366,transcription by RNA polymerase II;GO:0006368,transcription elongation from RNA polymerase II promoter;GO:0006511,ubiquitin-dependent protein catabolic process;GO:0016032,viral process	hsa:6921,path:hsa04120,Ubiquitin mediated proteolysis;hsa:6921,path:hsa04066,HIF-1 signaling pathway;hsa:6921,path:hsa05200,Pathways in cancer;hsa:6921,path:hsa05211,Renal cell carcinoma;hsa:6921,path:hsa05170,Human immunodeficiency virus 1 infection
TMCO1_HUMAN	Q9UM00	TMCO1	Calcium load-activated calcium channel	1.866815104	3.528828584	0.208453005	0.098103588	2.697821844	0.1532782965	2.697821844	0.1532782965	17.6008078482266	0.004867	1	0.0568155739567805	0.004784	-1	GO:0005737,cytoplasm;GO:0005783,endoplasmic reticulum;GO:0000139,Golgi membrane;GO:0030176,integral component of endoplasmic reticulum membrane	GO:0005262,calcium channel activity;GO:0043022,ribosome binding	GO:0070588,calcium ion transmembrane transport;GO:0006874,cellular calcium ion homeostasis;GO:0032469,endoplasmic reticulum calcium ion homeostasis;GO:0006983,ER overload response	
TGO1_HUMAN	Q5JRA6	MIA3	Transport and Golgi organization protein 1 homolog	0.146512956	0.116609183	0.217828667	0.260956361	0.1315610695	0.239392514	0.1315610695	0.239392514	0.549562170101944	0.270762	0	1.81963034285002	0.271069	0	GO:0070971,endoplasmic reticulum exit site;GO:0005788,endoplasmic reticulum lumen;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane	GO:0038024,cargo receptor activity	GO:0002042,cell migration involved in sprouting angiogenesis;GO:0044267,cellular protein metabolic process;GO:0140052,cellular response to oxidised low-density lipoprotein particle stimulus;GO:0090110,COPII-coated vesicle cargo loading;GO:0007029,endoplasmic reticulum organization;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006887,exocytosis;GO:0042953,lipoprotein transport;GO:0007162,negative regulation of cell adhesion;GO:0030336,negative regulation of cell migration;GO:1903038,negative regulation of leukocyte cell-cell adhesion;GO:2000402,negative regulation of lymphocyte migration;GO:0002687,positive regulation of leukocyte migration;GO:0043687,post-translational protein modification;GO:0070973,protein localization to endoplasmic reticulum exit site;GO:0009306,protein secretion;GO:0015031,protein transport;GO:0035459,vesicle cargo loading;GO:0042060,wound healing	
1433F_HUMAN	Q04917	YWHAH	14-3-3 protein eta	2.13885353	5.630319691	1.789704161	2.393370021	3.8845866105	2.091537091	3.8845866105	2.091537091	1.85728793776385	0.245198	0	0.538419476951961	0.244674	0	GO:0016021,integral component of membrane;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0014704,intercalated disc;GO:0005739,mitochondrion;GO:0005886,plasma membrane	GO:0003779,actin binding;GO:0019899,enzyme binding;GO:0035259,glucocorticoid receptor binding;GO:0042802,identical protein binding;GO:0005159,insulin-like growth factor receptor binding;GO:0044325,ion channel binding;GO:0019904,protein domain specific binding;GO:0046982,protein heterodimerization activity;GO:0017080,sodium channel regulator activity	GO:0006713,glucocorticoid catabolic process;GO:0042921,glucocorticoid receptor signaling pathway;GO:0006886,intracellular protein transport;GO:0086010,membrane depolarization during action potential;GO:0050774,negative regulation of dendrite morphogenesis;GO:1900740,positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0045893,positive regulation of transcription, DNA-templated;GO:0045664,regulation of neuron differentiation;GO:2000649,regulation of sodium ion transmembrane transporter activity;GO:0002028,regulation of sodium ion transport;GO:0048167,regulation of synaptic plasticity;GO:0021762,substantia nigra development	hsa:7533,path:hsa04390,Hippo signaling pathway;hsa:7533,path:hsa04151,PI3K-Akt signaling pathway;hsa:7533,path:hsa04110,Cell cycle;hsa:7533,path:hsa04114,Oocyte meiosis;hsa:7533,path:hsa05203,Viral carcinogenesis;hsa:7533,path:hsa05160,Hepatitis C
PYRG2_HUMAN	Q9NRF8	CTPS2	CTP synthase 2	0.182199207	0.129990196	0.304796952	0.389927471	0.1560947015	0.3473622115	0.1560947015	0.3473622115	0.449371567580545	0.179284	0	2.22532993216301	0.179620	0	GO:0097268,cytoophidium;GO:0005737,cytoplasm;GO:0005829,cytosol	GO:0005524,ATP binding;GO:0003883,CTP synthase activity;GO:0042802,identical protein binding	GO:0044210,'de novo' CTP biosynthetic process;GO:0006241,CTP biosynthetic process;GO:0006541,glutamine metabolic process;GO:0015949,nucleobase-containing small molecule interconversion;GO:0019856,pyrimidine nucleobase biosynthetic process;GO:0006220,pyrimidine nucleotide metabolic process	hsa:56474,path:hsa00240,Pyrimidine metabolism
CATC_HUMAN	P53634	CTSC	Dipeptidyl peptidase 1	2.713986673	16.95944637	0.719295951	0.226177759	9.8367165215	0.472736855	9.8367165215	0.472736855	20.8080170129744	0.003203	1	0.048058399768535	0.003143	-1	GO:0035578,azurophil granule lumen;GO:0005813,centrosome;GO:0062023,collagen-containing extracellular matrix;GO:0030134,COPII-coated ER to Golgi transport vesicle;GO:0005788,endoplasmic reticulum lumen;GO:0033116,endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0005764,lysosome;GO:0016020,membrane;GO:0005654,nucleoplasm	GO:0051087,chaperone binding;GO:0031404,chloride ion binding;GO:0004197,cysteine-type endopeptidase activity;GO:0008234,cysteine-type peptidase activity;GO:0008239,dipeptidyl-peptidase activity;GO:0042802,identical protein binding;GO:0016505,peptidase activator activity involved in apoptotic process;GO:0019902,phosphatase binding;GO:0043621,protein self-association;GO:0004252,serine-type endopeptidase activity	GO:0007568,aging;GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006955,immune response;GO:0031642,negative regulation of myelination;GO:0043312,neutrophil degranulation;GO:2001235,positive regulation of apoptotic signaling pathway;GO:1903980,positive regulation of microglial cell activation;GO:1903052,positive regulation of proteolysis involved in cellular protein catabolic process;GO:0006508,proteolysis;GO:0051603,proteolysis involved in cellular protein catabolic process;GO:0010033,response to organic substance;GO:0001913,T cell mediated cytotoxicity	hsa:1075,path:hsa04142,Lysosome;hsa:1075,path:hsa04210,Apoptosis
NIPS2_HUMAN	O75323	NIPSNAP2	Protein NipSnap homolog 2	0.761575668	0.963677453	0.888602503	0.877791026	0.8626265605	0.8831967645	0.8626265605	0.8831967645	0.976709375728244	0.441177	0	1.02384601279617	0.440997	0	GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion		GO:0007005,mitochondrion organization;GO:0006119,oxidative phosphorylation;GO:1901843,positive regulation of high voltage-gated calcium channel activity	
SPCS3_HUMAN	P61009	SPCS3	Signal peptidase complex subunit 3	3.818505988	4.951077145	0.438059522	0.169699634	4.3847915665	0.303879578	4.3847915665	0.303879578	14.4293723038539	0.007810	1	0.0693030839416982	0.007692	-1	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0005787,signal peptidase complex	GO:0008233,peptidase activity	GO:0045047,protein targeting to ER;GO:0006508,proteolysis;GO:0006465,signal peptide processing;GO:0019082,viral protein processing	hsa:60559,path:hsa03060,Protein export
FBN1_HUMAN	P35555	FBN1	Fibrillin-1	1.145135244	3.275189212	0.82626245	4.544371725	2.210162228	2.6853170875	2.210162228	2.6853170875	0.823054468423182	0.498518	0	1.21498641750383	0.498464	0	GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0001527,microfibril	GO:0005509,calcium ion binding;GO:0030023,extracellular matrix constituent conferring elasticity;GO:0005201,extracellular matrix structural constituent;GO:0008201,heparin binding;GO:0005179,hormone activity;GO:0042802,identical protein binding;GO:0005178,integrin binding;GO:0044877,protein-containing complex binding	GO:0034199,activation of protein kinase A activity;GO:0009653,anatomical structure morphogenesis;GO:0043010,camera-type eye development;GO:0033627,cell adhesion mediated by integrin;GO:0044267,cellular protein metabolic process;GO:1990314,cellular response to insulin-like growth factor stimulus;GO:0071560,cellular response to transforming growth factor beta stimulus;GO:0048048,embryonic eye morphogenesis;GO:0030198,extracellular matrix organization;GO:0042593,glucose homeostasis;GO:0006006,glucose metabolic process;GO:0007507,heart development;GO:0001656,metanephros development;GO:2001205,negative regulation of osteoclast development;GO:0045671,negative regulation of osteoclast differentiation;GO:0048050,post-embryonic eye morphogenesis;GO:0043687,post-translational protein modification;GO:0010737,protein kinase A signaling;GO:0035582,sequestering of BMP in extracellular matrix;GO:0035583,sequestering of TGFbeta in extracellular matrix;GO:0001501,skeletal system development	hsa:2200,path:hsa04350,TGF-beta signaling pathway
RT29_HUMAN	P51398	DAP3	28S ribosomal protein S29, mitochondrial	0.616935146	0.277780811	0.725236263	0.316160759	0.4473579785	0.520698511	0.4473579785	0.520698511	0.859149717253561	0.484090	0	1.16394148763349	0.484004	0	GO:0005743,mitochondrial inner membrane;GO:0005763,mitochondrial small ribosomal subunit;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005840,ribosome;GO:0005761,mitochondrial ribosome;GO:0015935,small ribosomal subunit	GO:0005525,GTP binding;GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome	GO:0097190,apoptotic signaling pathway;GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination;GO:0006915,apoptotic process	
GBP6_HUMAN	Q6ZN66	GBP6	Guanylate-binding protein 6	2.116076761	1.07030948	0.724129987	1.850455721	1.5931931205	1.287292854	1.5931931205	1.287292854	1.23763067242196	0.364091	0	0.807995488705099	0.363752	0	GO:0031410,cytoplasmic vesicle;GO:0070062,extracellular exosome	GO:0005525,GTP binding;GO:0003924,GTPase activity	GO:0071346,cellular response to interferon-gamma;GO:0042742,defense response to bacterium;GO:0050830,defense response to Gram-positive bacterium;GO:0042832,defense response to protozoan;GO:0006955,immune response	
ACOT1_HUMAN	Q86TX2	ACOT1	Acyl-coenzyme A thioesterase 1	0.739687261	0.963538236	1.218670348	1.908098065	0.8516127485	1.5633842065	0.8516127485	1.5633842065	0.544723904053332	0.266306	0	1.83579239419993	0.266616	0	GO:0005829,cytosol	GO:0047617,acyl-CoA hydrolase activity;GO:0052689,carboxylic ester hydrolase activity;GO:0102991,myristoyl-CoA hydrolase activity;GO:0016290,palmitoyl-CoA hydrolase activity;GO:0016790,thiolester hydrolase activity	GO:0006637,acyl-CoA metabolic process;GO:0006631,fatty acid metabolic process;GO:0001676,long-chain fatty acid metabolic process;GO:0000038,very long-chain fatty acid metabolic process	hsa:641371,path:hsa00062,Fatty acid elongation;hsa:641371,path:hsa01040,Biosynthesis of unsaturated fatty acids;hsa:641371,path:hsa04913,Ovarian steroidogenesis
NBAS_HUMAN	A2RRP1	NBAS	Neuroblastoma-amplified sequence	0.116108652	0.080891393	0.228812701	2.55E-05	0.0985000225	0.1144191005	0.0985000225	0.1144191005	0.860870449685103	0.483417	0	1.16161496815902	0.483330	0	GO:0005829,cytosol;GO:0070939,Dsl1/NZR complex;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016020,membrane;GO:0016021,integral component of membrane	GO:0000149,SNARE binding	GO:2000623,negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000956,nuclear-transcribed mRNA catabolic process;GO:0015031,protein transport;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	
STX18_HUMAN	Q9P2W9	STX18	Syntaxin-18	0.010920567	0.198733842	0.051361389	0.061748212	0.1048272045	0.0565548005	0.1048272045	0.0565548005	1.85355095541359	0.245732	0	0.539504995575838	0.245209	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0031201,SNARE complex	GO:0019904,protein domain specific binding;GO:0005484,SNAP receptor activity	GO:0090158,endoplasmic reticulum membrane organization;GO:0006886,intracellular protein transport;GO:1902953,positive regulation of ER to Golgi vesicle-mediated transport;GO:1902117,positive regulation of organelle assembly;GO:1903358,regulation of Golgi organization;GO:0006890,retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	hsa:53407,path:hsa04130,SNARE interactions in vesicular transport;hsa:53407,path:hsa04145,Phagosome
TPPC5_HUMAN	Q8IUR0	TRAPPC5	Trafficking protein particle complex subunit 5	1.336203532	3.21687662	0.225299732	0.094074558	2.276540076	0.159687145	2.276540076	0.159687145	14.2562513469697	0.008031	1	0.0701446667614034	0.007911	-1	GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0030008,TRAPP complex;GO:1990070,TRAPPI protein complex;GO:1990071,TRAPPII protein complex;GO:1990072,TRAPPIII protein complex;GO:0005794,Golgi apparatus		GO:0048208,COPII vesicle coating;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048193,Golgi vesicle transport	
NUDT3_HUMAN	O95989	NUDT3	Diphosphoinositol polyphosphate phosphohydrolase 1	0.217210767	0.177241226	0.053090897	0.025734125	0.1972259965	0.039412511	0.1972259965	0.039412511	5.00414694460853	0.063619	0	0.199834259678845	0.063180	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005634,nucleus	GO:0034431,bis(5'-adenosyl)-hexaphosphatase activity;GO:0034432,bis(5'-adenosyl)-pentaphosphatase activity;GO:0008486,diphosphoinositol-polyphosphate diphosphatase activity;GO:0000298,endopolyphosphatase activity;GO:0052842,inositol diphosphate pentakisphosphate diphosphatase activity;GO:0052840,inositol diphosphate tetrakisphosphate diphosphatase activity;GO:0050072,m7G(5')pppN diphosphatase activity;GO:0000287,magnesium ion binding	GO:1901911,adenosine 5'-(hexahydrogen pentaphosphate) catabolic process;GO:0007267,cell-cell signaling;GO:1901909,diadenosine hexaphosphate catabolic process;GO:1901907,diadenosine pentaphosphate catabolic process;GO:0015961,diadenosine polyphosphate catabolic process;GO:0071544,diphosphoinositol polyphosphate catabolic process;GO:0071543,diphosphoinositol polyphosphate metabolic process;GO:0043647,inositol phosphate metabolic process	
SCAM3_HUMAN	O14828	SCAMP3	Secretory carrier-associated membrane protein 3	1.170673927	0.789137742	0.789998274	0.875562913	0.9799058345	0.8327805935	0.9799058345	0.8327805935	1.17666747057789	0.380194	0	0.849857776308607	0.379887	0	GO:0070062,extracellular exosome;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0055038,recycling endosome membrane;GO:0032588,trans-Golgi network membrane	GO:0031625,ubiquitin protein ligase binding	GO:0006892,post-Golgi vesicle-mediated transport;GO:0015031,protein transport	
A2GL_HUMAN	P02750	LRG1	Leucine-rich alpha-2-glycoprotein	0.592567058	0.559925535	0.691200928	2.715143294	0.5762462965	1.703172111	0.5762462965	1.703172111	0.338337090408123	0.088217	0	2.95563220335595	0.088502	0	GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1904813,ficolin-1-rich granule lumen;GO:0043231,intracellular membrane-bounded organelle;GO:0016020,membrane;GO:0035580,specific granule lumen;GO:1904724,tertiary granule lumen	GO:0005160,transforming growth factor beta receptor binding	GO:0050873,brown fat cell differentiation;GO:0043312,neutrophil degranulation;GO:0045766,positive regulation of angiogenesis;GO:0001938,positive regulation of endothelial cell proliferation;GO:0030511,positive regulation of transforming growth factor beta receptor signaling pathway;GO:0009617,response to bacterium	
ACAD8_HUMAN	Q9UKU7	ACAD8	Isobutyryl-CoA dehydrogenase, mitochondrial	0.156752739	0.148888135	0.366043739	0.152931802	0.152820437	0.2594877705	0.152820437	0.2594877705	0.588931172769855	0.306858	0	1.69799128698997	0.307141	0	GO:0005759,mitochondrial matrix	GO:0003995,acyl-CoA dehydrogenase activity;GO:0050660,flavin adenine dinucleotide binding;GO:0016627,oxidoreductase activity, acting on the CH-CH group of donors	GO:0009083,branched-chain amino acid catabolic process;GO:0006629,lipid metabolic process;GO:0006574,valine catabolic process	hsa:27034,path:hsa00280,Valine, leucine and isoleucine degradation
LTOR3_HUMAN	Q9UHA4	LAMTOR3	Ragulator complex protein LAMTOR3	0.33838477	0.467849793	0.505800976	0.179842865	0.4031172815	0.3428219205	0.4031172815	0.3428219205	1.17587953801805	0.380409	0	0.850427248428445	0.380102	0	GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0005765,lysosomal membrane;GO:0005886,plasma membrane;GO:0071986,Ragulator complex;GO:0035579,specific granule membrane;GO:0070821,tertiary granule membrane	GO:0019209,kinase activator activity	GO:0000186,activation of MAPKK activity;GO:0007050,cell cycle arrest;GO:0034613,cellular protein localization;GO:0034198,cellular response to amino acid starvation;GO:0071230,cellular response to amino acid stimulus;GO:0000165,MAPK cascade;GO:0043312,neutrophil degranulation;GO:0032008,positive regulation of TOR signaling;GO:1902414,protein localization to cell junction;GO:0016241,regulation of macroautophagy	hsa:8649,path:hsa04010,MAPK signaling pathway;hsa:8649,path:hsa04150,mTOR signaling pathway
THOP1_HUMAN	P52888	THOP1	Thimet oligopeptidase	0.248485535	0.062067305	0.346632736	0.232894701	0.15527642	0.2897637185	0.15527642	0.2897637185	0.535872540578264	0.258150	0	1.86611539923447	0.258464	0	GO:0005829,cytosol;GO:0005758,mitochondrial intermembrane space	GO:0046872,metal ion binding;GO:0004222,metalloendopeptidase activity;GO:0042277,peptide binding	GO:0006518,peptide metabolic process;GO:0000209,protein polyubiquitination;GO:0006508,proteolysis	hsa:7064,path:hsa04614,Renin-angiotensin system;hsa:7064,path:hsa05143,African trypanosomiasis
AB1IP_HUMAN	Q7Z5R6	APBB1IP	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein	8.093441709	28.96585394	11.27185776	8.518016923	18.5296478245	9.8949373415	18.5296478245	9.8949373415	1.87263922802072	0.243021	0	0.534005688355116	0.242495	0	GO:0005856,cytoskeleton;GO:0005829,cytosol;GO:0005925,focal adhesion;GO:0030027,lamellipodium;GO:0005886,plasma membrane;GO:0042101,T cell receptor complex		GO:0045785,positive regulation of cell adhesion;GO:0007165,signal transduction;GO:0002291,T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	hsa:54518,path:hsa04015,Rap1 signaling pathway;hsa:54518,path:hsa04611,Platelet activation
ACOX3_HUMAN	O15254	ACOX3	Peroxisomal acyl-coenzyme A oxidase 3	0.078593583	0.132338343	0.25052731	0.050379626	0.105465963	0.150453468	0.105465963	0.150453468	0.700987251420486	0.405711	0	1.42655946734208	0.405905	0	GO:0005829,cytosol;GO:0016020,membrane;GO:0005782,peroxisomal matrix;GO:0005777,peroxisome	GO:0003997,acyl-CoA oxidase activity;GO:0071949,FAD binding;GO:0005504,fatty acid binding;GO:0050660,flavin adenine dinucleotide binding;GO:0016402,pristanoyl-CoA oxidase activity;GO:0016627,oxidoreductase activity, acting on the CH-CH group of donors	GO:0033540,fatty acid beta-oxidation using acyl-CoA oxidase;GO:0055088,lipid homeostasis;GO:0008104,protein localization	hsa:8310,path:hsa00640,Propanoate metabolism;hsa:8310,path:hsa00071,Fatty acid degradation;hsa:8310,path:hsa00592,alpha-Linolenic acid metabolism;hsa:8310,path:hsa01040,Biosynthesis of unsaturated fatty acids;hsa:8310,path:hsa00410,beta-Alanine metabolism;hsa:8310,path:hsa04024,cAMP signaling pathway;hsa:8310,path:hsa04146,Peroxisome;hsa:8310,path:hsa03320,PPAR signaling pathway
RM38_HUMAN	Q96DV4	MRPL38	39S ribosomal protein L38, mitochondrial	0.148763492	0.091017274	0.224481165	2.55E-05	0.119890383	0.1122533325	0.119890383	0.1122533325	1.06803406482387	0.411641	0	0.936299723890281	0.411398	0	GO:0005743,mitochondrial inner membrane;GO:0005762,mitochondrial large ribosomal subunit;GO:0005739,mitochondrion		GO:0070125,mitochondrial translational elongation;GO:0070126,mitochondrial translational termination	
VATE1_HUMAN	P36543	ATP6V1E1	V-type proton ATPase subunit E 1	1.143839344	1.441424234	1.417814183	0.433163338	1.292631789	0.9254887605	1.292631789	0.9254887605	1.39670176902165	0.326550	0	0.71597245895985	0.326143	0	GO:0016324,apical plasma membrane;GO:0005829,cytosol;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005765,lysosomal membrane;GO:0005902,microvillus;GO:0016469,proton-transporting two-sector ATPase complex;GO:0033178,proton-transporting two-sector ATPase complex, catalytic domain	GO:0051117,ATPase binding;GO:0008553,P-type proton-exporting transporter activity;GO:0046961,proton-transporting ATPase activity, rotational mechanism	GO:0034198,cellular response to amino acid starvation;GO:0008286,insulin receptor signaling pathway;GO:0034220,ion transmembrane transport;GO:0090383,phagosome acidification;GO:1902600,proton transmembrane transport;GO:0016241,regulation of macroautophagy;GO:0033572,transferrin transport	hsa:529,path:hsa00190,Oxidative phosphorylation;hsa:529,path:hsa04150,mTOR signaling pathway;hsa:529,path:hsa04145,Phagosome;hsa:529,path:hsa04966,Collecting duct acid secretion;hsa:529,path:hsa04721,Synaptic vesicle cycle;hsa:529,path:hsa05323,Rheumatoid arthritis;hsa:529,path:hsa05110,Vibrio cholerae infection;hsa:529,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:529,path:hsa05165,Human papillomavirus infection
PCAT1_HUMAN	Q8NF37	LPCAT1	Lysophosphatidylcholine acyltransferase 1	2.364268124	0.313227556	5.268167729	2.201416035	1.33874784	3.734791882	1.33874784	3.734791882	0.358453129999601	0.103195	0	2.7897650105639	0.103497	0	GO:0035577,azurophil granule membrane;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0005811,lipid droplet;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0003841,1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0047184,1-acylglycerophosphocholine O-acyltransferase activity;GO:0047159,1-alkenylglycerophosphocholine O-acyltransferase activity;GO:0047192,1-alkylglycerophosphocholine O-acetyltransferase activity;GO:0047191,1-alkylglycerophosphocholine O-acyltransferase activity;GO:0005509,calcium ion binding;GO:0050200,plasmalogen synthase activity;GO:0016746,transferase activity, transferring acyl groups	GO:2001246,negative regulation of phosphatidylcholine biosynthetic process;GO:0043312,neutrophil degranulation;GO:0006654,phosphatidic acid biosynthetic process;GO:0036151,phosphatidylcholine acyl-chain remodeling;GO:0006656,phosphatidylcholine biosynthetic process;GO:0036148,phosphatidylglycerol acyl-chain remodeling;GO:0008654,phospholipid biosynthetic process;GO:0045732,positive regulation of protein catabolic process;GO:0060041,retina development in camera-type eye;GO:0043129,surfactant homeostasis;GO:0006644,phospholipid metabolic process	hsa:79888,path:hsa00564,Glycerophospholipid metabolism;hsa:79888,path:hsa00565,Ether lipid metabolism
PDCD5_HUMAN	O14737	PDCD5	Programmed cell death protein 5	0.617075084	0.94353647	0.02671603	2.55E-05	0.780305777	0.013370765	0.780305777	0.013370765	58.3590974039257	0.000162	1	0.0171352890035056	0.000157	-1	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005634,nucleus	GO:0010698,acetyltransferase activator activity;GO:0048487,beta-tubulin binding;GO:0003677,DNA binding;GO:0008201,heparin binding	GO:0006915,apoptotic process;GO:0071560,cellular response to transforming growth factor beta stimulus;GO:0008285,negative regulation of cell population proliferation;GO:1903645,negative regulation of chaperone-mediated protein folding;GO:0043065,positive regulation of apoptotic process;GO:0043280,positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0010628,positive regulation of gene expression;GO:1903638,positive regulation of protein insertion into mitochondrial outer membrane;GO:0090200,positive regulation of release of cytochrome c from mitochondria	
TPP1_HUMAN	O14773	TPP1	Tripeptidyl-peptidase 1	2.119821672	4.182575899	7.717344288	5.723781708	3.1511987855	6.720562998	3.1511987855	6.720562998	0.468889107421176	0.196795	0	2.1327004278258	0.197130	0	GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0043202,lysosomal lumen;GO:0005764,lysosome;GO:0042470,melanosome;GO:0045121,membrane raft;GO:0055037,recycling endosome	GO:0004175,endopeptidase activity;GO:0035727,lysophosphatidic acid binding;GO:0046872,metal ion binding;GO:0008233,peptidase activity;GO:0042277,peptide binding;GO:0004252,serine-type endopeptidase activity;GO:0008236,serine-type peptidase activity;GO:0120146,sulfatide binding;GO:0008240,tripeptidyl-peptidase activity	GO:0045453,bone resorption;GO:0007417,central nervous system development;GO:0030855,epithelial cell differentiation;GO:0036498,IRE1-mediated unfolded protein response;GO:0006629,lipid metabolic process;GO:1905146,lysosomal protein catabolic process;GO:0007040,lysosome organization;GO:0007399,nervous system development;GO:0050885,neuromuscular process controlling balance;GO:0043171,peptide catabolic process;GO:0030163,protein catabolic process;GO:0070198,protein localization to chromosome, telomeric region;GO:0006508,proteolysis	hsa:1200,path:hsa04142,Lysosome
NB5R2_HUMAN	Q6BCY4	CYB5R2	NADH-cytochrome b5 reductase 2	0.041524102	0.045743285	0.025639472	0.097990236	0.0436336935	0.061814854	0.0436336935	0.061814854	0.705877158587158	0.409835	0	1.41667709152332	0.410025	0	GO:0005789,endoplasmic reticulum membrane;GO:0016020,membrane;GO:0005634,nucleus;GO:0016021,integral component of membrane	GO:0004128,cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0071949,FAD binding;GO:0016491,oxidoreductase activity	GO:0015701,bicarbonate transport;GO:0016126,sterol biosynthetic process	hsa:51700,path:hsa00520,Amino sugar and nucleotide sugar metabolism
RL10_HUMAN	P27635	RPL10	60S ribosomal protein L10	9.008973167	9.554444809	1.175447614	1.065026313	9.281708988	1.1202369635	9.281708988	1.1202369635	8.28548716960811	0.025583	1	0.120692963434677	0.025317	-1	GO:0005829,cytosol;GO:0022625,cytosolic large ribosomal subunit;GO:0022626,cytosolic ribosome;GO:0005783,endoplasmic reticulum;GO:0016020,membrane;GO:0005634,nucleus;GO:0032991,protein-containing complex;GO:0005840,ribosome	GO:0003723,RNA binding;GO:0003735,structural constituent of ribosome;GO:0045182,translation regulator activity	GO:0002181,cytoplasmic translation;GO:1990403,embryonic brain development;GO:0043066,negative regulation of apoptotic process;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0000184,nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006417,regulation of translation;GO:0000027,ribosomal large subunit assembly;GO:0006364,rRNA processing;GO:0006614,SRP-dependent cotranslational protein targeting to membrane;GO:0006412,translation;GO:0006413,translational initiation;GO:0019083,viral transcription	hsa:6134,path:hsa03010,Ribosome
CLAP1_HUMAN	Q7Z460	CLASP1	CLIP-associating protein 1	0.082100075	0.072155317	0.17307929	0.020544916	0.077127696	0.096812103	0.077127696	0.096812103	0.796674110054194	0.482832	0	1.25521839781134	0.482942	0	GO:0045180,basal cortex;GO:0005938,cell cortex;GO:0031592,centrosomal corona;GO:0005813,centrosome;GO:0000777,condensed chromosome kinetochore;GO:0030981,cortical microtubule cytoskeleton;GO:0005881,cytoplasmic microtubule;GO:0005829,cytosol;GO:0005794,Golgi apparatus;GO:0000776,kinetochore;GO:0005828,kinetochore microtubule;GO:0016020,membrane;GO:0005815,microtubule organizing center;GO:0035371,microtubule plus-end;GO:0072686,mitotic spindle;GO:0005876,spindle microtubule	GO:0002162,dystroglycan binding;GO:0043515,kinetochore binding;GO:0008017,microtubule binding;GO:0051010,microtubule plus-end binding	GO:0030953,astral microtubule organization;GO:0051301,cell division;GO:0097711,ciliary basal body-plasma membrane docking;GO:0090162,establishment of epithelial cell polarity;GO:0040001,establishment of mitotic spindle localization;GO:0051294,establishment of spindle orientation;GO:0007163,establishment or maintenance of cell polarity;GO:0010458,exit from mitosis;GO:0000086,G2/M transition of mitotic cell cycle;GO:0007030,Golgi organization;GO:0034453,microtubule anchoring;GO:0001578,microtubule bundle formation;GO:0000226,microtubule cytoskeleton organization;GO:0007020,microtubule nucleation;GO:0031023,microtubule organizing center organization;GO:0090307,mitotic spindle assembly;GO:0007052,mitotic spindle organization;GO:0007026,negative regulation of microtubule depolymerization;GO:0031111,negative regulation of microtubule polymerization or depolymerization;GO:0051497,negative regulation of stress fiber assembly;GO:1903690,negative regulation of wound healing, spreading of epidermal cells;GO:1904261,positive regulation of basement membrane assembly involved in embryonic body morphogenesis;GO:0010634,positive regulation of epithelial cell migration;GO:0045921,positive regulation of exocytosis;GO:0090091,positive regulation of extracellular matrix disassembly;GO:0031116,positive regulation of microtubule polymerization;GO:0010717,regulation of epithelial to mesenchymal transition;GO:0051893,regulation of focal adhesion assembly;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0010470,regulation of gastrulation;GO:0070507,regulation of microtubule cytoskeleton organization;GO:0006903,vesicle targeting	
NPTN_HUMAN	Q9Y639	NPTN	Neuroplastin	0.272503482	0.585226267	0.748473611	1.056173854	0.4288648745	0.9023237325	0.4288648745	0.9023237325	0.475289365726619	0.202590	0	2.10398143133543	0.202924	0	GO:0030424,axon;GO:0009986,cell surface;GO:0030425,dendrite;GO:0098982,GABA-ergic synapse;GO:0098978,glutamatergic synapse;GO:0001772,immunological synapse;GO:0060077,inhibitory synapse;GO:0099061,integral component of postsynaptic density membrane;GO:0099059,integral component of presynaptic active zone membrane;GO:0005886,plasma membrane;GO:0042734,presynaptic membrane;GO:0098685,Schaffer collateral - CA1 synapse;GO:0016021,integral component of membrane	GO:0050839,cell adhesion molecule binding;GO:0098632,cell-cell adhesion mediator activity;GO:0044325,ion channel binding;GO:0005105,type 1 fibroblast growth factor receptor binding	GO:0007411,axon guidance;GO:0006874,cellular calcium ion homeostasis;GO:0070593,dendrite self-avoidance;GO:1904861,excitatory synapse assembly;GO:0007156,homophilic cell adhesion via plasma membrane adhesion molecules;GO:0060291,long-term synaptic potentiation;GO:0001818,negative regulation of cytokine production;GO:1903829,positive regulation of cellular protein localization;GO:0007204,positive regulation of cytosolic calcium ion concentration;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0045743,positive regulation of fibroblast growth factor receptor signaling pathway;GO:0048170,positive regulation of long-term neuronal synaptic plasticity;GO:1900273,positive regulation of long-term synaptic potentiation;GO:0010976,positive regulation of neuron projection development;GO:0001934,positive regulation of protein phosphorylation;GO:1902683,regulation of receptor localization to synapse;GO:0099557,trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission;GO:0008542,visual learning;GO:0007155,cell adhesion	
CK054_HUMAN	Q9H0W9	C11orf54	Ester hydrolase C11orf54	0.334635911	0.402450188	0.624022508	0.261530308	0.3685430495	0.442776408	0.3685430495	0.442776408	0.832345723126242	0.494743	0	1.20142384614419	0.494681	0	GO:0070062,extracellular exosome;GO:0016604,nuclear body;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0016788,hydrolase activity, acting on ester bonds;GO:0008270,zinc ion binding;GO:0046872,metal ion binding		
DOK3_HUMAN	Q7L591	DOK3	Docking protein 3	0.117034268	0.098366558	0.163178873	0.286962798	0.107700413	0.2250708355	0.107700413	0.2250708355	0.478517853104962	0.205522	0	2.08978618772799	0.205855	0	GO:0101003,ficolin-1-rich granule membrane;GO:0005886,plasma membrane;GO:0030667,secretory granule membrane;GO:0005737,cytoplasm		GO:0043312,neutrophil degranulation;GO:0007265,Ras protein signal transduction	
DC1L2_HUMAN	O43237	DYNC1LI2	Cytoplasmic dynein 1 light intermediate chain 2	0.63266596	0.502710524	0.751656511	1.064769936	0.567688242	0.9082132235	0.567688242	0.9082132235	0.625060533486055	0.339514	0	1.59984504928323	0.339772	0	GO:0005813,centrosome;GO:0005868,cytoplasmic dynein complex;GO:0005829,cytosol;GO:0000776,kinetochore;GO:0005770,late endosome;GO:0005764,lysosome;GO:0016020,membrane;GO:0005874,microtubule;GO:0005737,cytoplasm	GO:0005524,ATP binding;GO:0045504,dynein heavy chain binding;GO:0042802,identical protein binding	GO:0035973,aggrephagy;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:1990090,cellular response to nerve growth factor stimulus;GO:0051642,centrosome localization;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0000226,microtubule cytoskeleton organization;GO:0007018,microtubule-based movement;GO:0007052,mitotic spindle organization;GO:0019058,viral life cycle	hsa:1783,path:hsa04145,Phagosome;hsa:1783,path:hsa04962,Vasopressin-regulated water reabsorption;hsa:1783,path:hsa05132,Salmonella infection
ACTZ_HUMAN	P61163	ACTR1A	Alpha-centractin	31.04322048	13.5651198	3.969948613	98.97318145	22.30417014	51.4715650315	22.30417014	51.4715650315	0.433329939090644	0.165115	0	2.30771038368254	0.165450	0	GO:0099738,cell cortex region;GO:0005814,centriole;GO:0005813,centrosome;GO:0030137,COPI-coated vesicle;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005869,dynactin complex;GO:0070062,extracellular exosome;GO:0002177,manchette;GO:0005875,microtubule associated complex;GO:0015630,microtubule cytoskeleton	GO:0005524,ATP binding	GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0097711,ciliary basal body-plasma membrane docking;GO:0006888,endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0000086,G2/M transition of mitotic cell cycle;GO:0010389,regulation of G2/M transition of mitotic cell cycle;GO:0007283,spermatogenesis;GO:0016192,vesicle-mediated transport	
RU1C_HUMAN	P09234	SNRPC	U1 small nuclear ribonucleoprotein C	1.108748498	0.752935996	0.139066318	0.023647009	0.930842247	0.0813566635	0.930842247	0.0813566635	11.4414997734021	0.013138	1	0.0874011292055162	0.012967	-1	GO:0015030,Cajal body;GO:0000243,commitment complex;GO:0005654,nucleoplasm;GO:0005685,U1 snRNP;GO:0071004,U2-type prespliceosome	GO:0003729,mRNA binding;GO:0030627,pre-mRNA 5'-splice site binding;GO:0042803,protein homodimerization activity;GO:0003723,RNA binding;GO:0003727,single-stranded RNA binding;GO:0008270,zinc ion binding;GO:0030619,U1 snRNA binding	GO:0000395,mRNA 5'-splice site recognition;GO:0000398,mRNA splicing, via spliceosome;GO:0000387,spliceosomal snRNP assembly	hsa:6631,path:hsa03040,Spliceosome
MSMO1_HUMAN	Q15800	MSMO1	Methylsterol monooxygenase 1	2.55E-05	0.041875087	0.029607171	2.55E-05	0.0209502935	0.0148163355	0.0209502935	0.0148163355	1.41399966948643	0.322817	0	0.707213743807455	0.322404	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:0000254,C-4 methylsterol oxidase activity;GO:0005506,iron ion binding;GO:0016491,oxidoreductase activity	GO:0006695,cholesterol biosynthetic process;GO:0006631,fatty acid metabolic process;GO:0008202,steroid metabolic process;GO:0016126,sterol biosynthetic process;GO:0008610,lipid biosynthetic process	hsa:6307,path:hsa00100,Steroid biosynthesis
VPS4B_HUMAN	O75351	VPS4B	Vacuolar protein sorting-associated protein 4B	0.600117334	0.335126783	0.809220929	0.97128745	0.4676220585	0.8902541895	0.4676220585	0.8902541895	0.525268023464887	0.248377	0	1.9037899802154	0.248696	0	GO:0005813,centrosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005768,endosome;GO:0010008,endosome membrane;GO:0070062,extracellular exosome;GO:0090543,Flemming body;GO:0031902,late endosome membrane;GO:0005634,nucleus;GO:0000922,spindle pole	GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0042802,identical protein binding;GO:0008568,microtubule-severing ATPase activity;GO:0008022,protein C-terminus binding;GO:0042803,protein homodimerization activity;GO:0044877,protein-containing complex binding	GO:0030301,cholesterol transport;GO:0031122,cytoplasmic microtubule organization;GO:0016197,endosomal transport;GO:0032510,endosome to lysosome transport via multivesicular body sorting pathway;GO:1904903,ESCRT III complex disassembly;GO:0061738,late endosomal microautophagy;GO:0016236,macroautophagy;GO:0061952,midbody abscission;GO:0007080,mitotic metaphase plate congression;GO:0036258,multivesicular body assembly;GO:0060548,negative regulation of cell death;GO:1903542,negative regulation of exosomal secretion;GO:0006997,nucleus organization;GO:1903724,positive regulation of centriole elongation;GO:1903543,positive regulation of exosomal secretion;GO:0010971,positive regulation of G2/M transition of mitotic cell cycle;GO:1903902,positive regulation of viral life cycle;GO:0048524,positive regulation of viral process;GO:1902188,positive regulation of viral release from host cell;GO:0006813,potassium ion transport;GO:0051261,protein depolymerization;GO:0015031,protein transport;GO:0010824,regulation of centrosome duplication;GO:1901673,regulation of mitotic spindle assembly;GO:0050792,regulation of viral process;GO:0033993,response to lipid;GO:0043162,ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0090611,ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway;GO:0039702,viral budding via host ESCRT complex;GO:0019058,viral life cycle;GO:0019076,viral release from host cell	hsa:9525,path:hsa04144,Endocytosis;hsa:9525,path:hsa04217,Necroptosis
CB078_HUMAN	A6NCI8	C2orf78	Uncharacterized protein C2orf78	2.55E-05	0.277353898	0.002921857	0.013143913	0.138689699	0.008032885	0.138689699	0.008032885	17.2652414418979	0.005101	1	0.0579198387329401	0.005015	-1				
PAK1_HUMAN	Q13153	PAK1	Serine/threonine-protein kinase PAK 1	0.741033506	0.796424914	1.047032801	0.522606298	0.76872921	0.7848195495	0.76872921	0.7848195495	0.979498039377012	0.440229	0	1.02093108898516	0.440047	0	GO:0005884,actin filament;GO:0030424,axon;GO:0005911,cell-cell junction;GO:0005694,chromosome;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0030425,dendrite;GO:0005925,focal adhesion;GO:0014704,intercalated disc;GO:0030027,lamellipodium;GO:0031965,nuclear membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0032991,protein-containing complex;GO:0001726,ruffle;GO:0032587,ruffle membrane;GO:0030018,Z disc	GO:0005524,ATP binding;GO:0005518,collagen binding;GO:0043015,gamma-tubulin binding;GO:0042802,identical protein binding;GO:0004672,protein kinase activity;GO:0019901,protein kinase binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity	GO:0031532,actin cytoskeleton reorganization;GO:0032147,activation of protein kinase activity;GO:0006915,apoptotic process;GO:0048754,branching morphogenesis of an epithelial tube;GO:0016477,cell migration;GO:0006974,cellular response to DNA damage stimulus;GO:0032869,cellular response to insulin stimulus;GO:0021549,cerebellum development;GO:0006338,chromatin remodeling;GO:0048013,ephrin receptor signaling pathway;GO:0030010,establishment of cell polarity;GO:0006887,exocytosis;GO:0038095,Fc-epsilon receptor signaling pathway;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0048012,hepatocyte growth factor receptor signaling pathway;GO:0061052,negative regulation of cell growth involved in cardiac muscle cell development;GO:0060244,negative regulation of cell proliferation involved in contact inhibition;GO:0048812,neuron projection morphogenesis;GO:0016310,phosphorylation;GO:0045773,positive regulation of axon extension;GO:0030335,positive regulation of cell migration;GO:0008284,positive regulation of cell population proliferation;GO:0010763,positive regulation of fibroblast migration;GO:0046628,positive regulation of insulin receptor signaling pathway;GO:0033148,positive regulation of intracellular estrogen receptor signaling pathway;GO:0043507,positive regulation of JUN kinase activity;GO:0090063,positive regulation of microtubule nucleation;GO:0031116,positive regulation of microtubule polymerization;GO:0033138,positive regulation of peptidyl-serine phosphorylation;GO:0001934,positive regulation of protein phosphorylation;GO:0090314,positive regulation of protein targeting to membrane;GO:0051496,positive regulation of stress fiber assembly;GO:1904754,positive regulation of vascular associated smooth muscle cell migration;GO:1904707,positive regulation of vascular associated smooth muscle cell proliferation;GO:0046777,protein autophosphorylation;GO:0006468,protein phosphorylation;GO:0050770,regulation of axonogenesis;GO:0001666,response to hypoxia;GO:0002223,stimulatory C-type lectin receptor signaling pathway;GO:0031098,stress-activated protein kinase signaling cascade;GO:0031295,T cell costimulation;GO:0050852,T cell receptor signaling pathway;GO:0042060,wound healing	hsa:5058,path:hsa04014,Ras signaling pathway;hsa:5058,path:hsa04010,MAPK signaling pathway;hsa:5058,path:hsa04012,ErbB signaling pathway;hsa:5058,path:hsa04392,Hippo signaling pathway - multiple species;hsa:5058,path:hsa04024,cAMP signaling pathway;hsa:5058,path:hsa04510,Focal adhesion;hsa:5058,path:hsa04810,Regulation of actin cytoskeleton;hsa:5058,path:hsa04625,C-type lectin receptor signaling pathway;hsa:5058,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:5058,path:hsa04660,T cell receptor signaling pathway;hsa:5058,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:5058,path:hsa04062,Chemokine signaling pathway;hsa:5058,path:hsa04360,Axon guidance;hsa:5058,path:hsa05205,Proteoglycans in cancer;hsa:5058,path:hsa05211,Renal cell carcinoma;hsa:5058,path:hsa05120,Epithelial cell signaling in Helicobacter pylori infection;hsa:5058,path:hsa05130,Pathogenic Escherichia coli infection;hsa:5058,path:hsa05132,Salmonella infection;hsa:5058,path:hsa05170,Human immunodeficiency virus 1 infection
CLIC4_HUMAN	Q9Y696	CLIC4	Chloride intracellular channel protein 4	2.457062608	2.887853956	1.994235198	2.376492204	2.672458282	2.185363701	2.672458282	2.185363701	1.22288948094869	0.367890	0	0.817735384578026	0.367559	0	GO:0015629,actin cytoskeleton;GO:0045177,apical part of cell;GO:0009986,cell surface;GO:0005911,cell-cell junction;GO:0005813,centrosome;GO:0034707,chloride channel complex;GO:0005737,cytoplasm;GO:0030659,cytoplasmic vesicle membrane;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005902,microvillus;GO:0030496,midbody;GO:0005739,mitochondrion;GO:0016363,nuclear matrix;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane	GO:0005254,chloride channel activity;GO:0005244,voltage-gated ion channel activity	GO:0001525,angiogenesis;GO:0048754,branching morphogenesis of an epithelial tube;GO:0030154,cell differentiation;GO:0071277,cellular response to calcium ion;GO:0006821,chloride transport;GO:0001886,endothelial cell morphogenesis;GO:0035088,establishment or maintenance of apical/basal cell polarity;GO:0009566,fertilization;GO:0030216,keratinocyte differentiation;GO:0035264,multicellular organism growth;GO:0030336,negative regulation of cell migration;GO:0051493,regulation of cytoskeleton organization;GO:0034765,regulation of ion transmembrane transport;GO:0061299,retina vasculature morphogenesis in camera-type eye;GO:0007035,vacuolar acidification	
EIFCL_HUMAN	B5ME19	EIF3CL	Eukaryotic translation initiation factor 3 subunit C-like protein	4.495050935	4.532272578	5.859691849	4.256670132	4.5136617565	5.0581809905	4.5136617565	5.0581809905	0.892348803844171	0.471361	0	1.1206380237101	0.471248	0	GO:0016282,eukaryotic 43S preinitiation complex;GO:0033290,eukaryotic 48S preinitiation complex;GO:0005852,eukaryotic translation initiation factor 3 complex	GO:0003743,translation initiation factor activity;GO:0031369,translation initiation factor binding	GO:0001732,formation of cytoplasmic translation initiation complex;GO:0006413,translational initiation	hsa:728689,path:hsa03013,RNA transport
AEBP1_HUMAN	Q8IUX7	AEBP1	Adipocyte enhancer-binding protein 1	7.368813084	3.281359512	2.69027382	25.53736463	5.325086298	14.113819225	5.325086298	14.113819225	0.377295912120484	0.117957	0	2.65043953002243	0.118272	0	GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005634,nucleus	GO:0005516,calmodulin binding;GO:0004180,carboxypeptidase activity;GO:0005518,collagen binding;GO:0001227,DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000977,RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0008270,zinc ion binding;GO:0004181,metallocarboxypeptidase activity	GO:0000122,negative regulation of transcription by RNA polymerase II;GO:1904026,regulation of collagen fibril organization	
HTAI2_HUMAN	Q9BUP3	HTATIP2	Oxidoreductase HTATIP2	0.246362004	0.386293649	0.506916353	2.55E-05	0.3163278265	0.2534709265	0.3163278265	0.2534709265	1.24798465397174	0.361457	0	0.801291904365549	0.361113	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0016020,membrane;GO:0005635,nuclear envelope;GO:0005634,nucleus	GO:0016491,oxidoreductase activity;GO:0004674,protein serine/threonine kinase activity;GO:0003713,transcription coactivator activity	GO:0001525,angiogenesis;GO:0006915,apoptotic process;GO:0030154,cell differentiation;GO:0051170,import into nucleus;GO:0043066,negative regulation of apoptotic process;GO:0043068,positive regulation of programmed cell death;GO:0045944,positive regulation of transcription by RNA polymerase II;GO:0046777,protein autophosphorylation;GO:0045765,regulation of angiogenesis;GO:0006357,regulation of transcription by RNA polymerase II;GO:0016032,viral process	
GSDME_HUMAN	O60443	GSDME	Gasdermin-E	0.140618373	0.168807627	0.183257897	0.181409764	0.154713	0.1823338305	0.154713	0.1823338305	0.84851505382047	0.488275	0	1.17852947392915	0.488199	0	GO:0005829,cytosol;GO:0016021,integral component of membrane;GO:0016020,membrane;GO:0005886,plasma membrane	GO:1901612,cardiolipin binding;GO:0005546,phosphatidylinositol-4,5-bisphosphate binding;GO:0022829,wide pore channel activity	GO:0008219,cell death;GO:0071356,cellular response to tumor necrosis factor;GO:0098586,cellular response to virus;GO:0140507,granzyme-mediated programmed cell death signaling pathway;GO:0060113,inner ear receptor cell differentiation;GO:0070265,necrotic cell death;GO:0008285,negative regulation of cell population proliferation;GO:0002839,positive regulation of immune response to tumor cell;GO:2001244,positive regulation of intrinsic apoptotic signaling pathway;GO:0043410,positive regulation of MAPK cascade;GO:0070269,pyroptosis;GO:0007605,sensory perception of sound;GO:0012501,programmed cell death	
FIBA_HUMAN	P02671	FGA	Fibrinogen alpha chain	19.19148369	84.25083377	132.2405305	106.9776508	51.72115873	119.60909065	51.72115873	119.60909065	0.432418292363299	0.164317	0	2.31257561870173	0.164652	0	GO:0072562,blood microparticle;GO:0005938,cell cortex;GO:0009986,cell surface;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1903561,extracellular vesicle;GO:0005577,fibrinogen complex;GO:0005886,plasma membrane;GO:0031091,platelet alpha granule;GO:0031093,platelet alpha granule lumen;GO:0045202,synapse	GO:0005201,extracellular matrix structural constituent;GO:0046872,metal ion binding;GO:0005102,signaling receptor binding;GO:0005198,structural molecule activity	GO:0002250,adaptive immune response;GO:1990000,amyloid fibril formation;GO:0007596,blood coagulation;GO:0072377,blood coagulation, common pathway;GO:0072378,blood coagulation, fibrin clot formation;GO:0007160,cell-matrix adhesion;GO:0044267,cellular protein metabolic process;GO:0034622,cellular protein-containing complex assembly;GO:0030198,extracellular matrix organization;GO:0042730,fibrinolysis;GO:0043152,induction of bacterial agglutination;GO:0045087,innate immune response;GO:2000261,negative regulation of blood coagulation, common pathway;GO:2000352,negative regulation of endothelial cell apoptotic process;GO:1902042,negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0031639,plasminogen activation;GO:0070527,platelet aggregation;GO:0002576,platelet degranulation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0045921,positive regulation of exocytosis;GO:0034116,positive regulation of heterotypic cell-cell adhesion;GO:0090277,positive regulation of peptide hormone secretion;GO:0050714,positive regulation of protein secretion;GO:1900026,positive regulation of substrate adhesion-dependent cell spreading;GO:0045907,positive regulation of vasoconstriction;GO:0043687,post-translational protein modification;GO:0051258,protein polymerization;GO:0065003,protein-containing complex assembly;GO:0051592,response to calcium ion;GO:0002224,toll-like receptor signaling pathway;GO:0030168,platelet activation	hsa:2243,path:hsa04610,Complement and coagulation cascades;hsa:2243,path:hsa04611,Platelet activation
LAMB3_HUMAN	Q13751	LAMB3	Laminin subunit beta-3	0.390677007	0.274233134	0.484686797	5.462865413	0.3324550705	2.973776105	0.3324550705	2.973776105	0.111795595485828	0.001167	-1	8.94489622470655	0.001181	1	GO:0062023,collagen-containing extracellular matrix;GO:0005576,extracellular region;GO:0043256,laminin complex	GO:0005201,extracellular matrix structural constituent;GO:0044877,protein-containing complex binding;GO:0005198,structural molecule activity	GO:0009887,animal organ morphogenesis;GO:0070831,basement membrane assembly;GO:0016477,cell migration;GO:0030199,collagen fibril organization;GO:0035987,endodermal cell differentiation;GO:0008544,epidermis development;GO:0030198,extracellular matrix organization;GO:0031581,hemidesmosome assembly;GO:0034446,substrate adhesion-dependent cell spreading;GO:0009888,tissue development	hsa:3914,path:hsa04151,PI3K-Akt signaling pathway;hsa:3914,path:hsa04512,ECM-receptor interaction;hsa:3914,path:hsa04510,Focal adhesion;hsa:3914,path:hsa05200,Pathways in cancer;hsa:3914,path:hsa05222,Small cell lung cancer;hsa:3914,path:hsa05165,Human papillomavirus infection;hsa:3914,path:hsa05146,Amoebiasis;hsa:3914,path:hsa05145,Toxoplasmosis
PRAF2_HUMAN	O60831	PRAF2	PRA1 family protein 2	0.66325139	3.924445702	0.045939827	0.046669874	2.293848546	0.0463048505	2.293848546	0.0463048505	49.5379754222508	0.000273	1	0.0201865334922596	0.000265	-1	GO:0010008,endosome membrane;GO:0016021,integral component of membrane;GO:0016020,membrane		GO:0015813,L-glutamate transmembrane transport;GO:0015031,protein transport	
GANAB_HUMAN	Q14697	GANAB	Neutral alpha-glucosidase AB	30.88067749	28.32582945	39.86983534	44.21253194	29.60325347	42.04118364	29.60325347	42.04118364	0.704148906070143	0.408380	0	1.42015416253503	0.408571	0	GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0017177,glucosidase II complex;GO:0005794,Golgi apparatus;GO:0043231,intracellular membrane-bounded organelle;GO:0042470,melanosome;GO:0016020,membrane	GO:0090599,alpha-glucosidase activity;GO:0030246,carbohydrate binding;GO:0033919,glucan 1,3-alpha-glucosidase activity;GO:0004553,hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0003723,RNA binding	GO:0005975,carbohydrate metabolic process;GO:0006491,N-glycan processing;GO:0006457,protein folding;GO:0019082,viral protein processing	hsa:23193,path:hsa00510,N-Glycan biosynthesis;hsa:23193,path:hsa04141,Protein processing in endoplasmic reticulum
VWA1_HUMAN	Q6PCB0	VWA1	von Willebrand factor A domain-containing protein 1	0.325860836	0.102676806	0.516786651	1.367243849	0.214268821	0.94201525	0.214268821	0.94201525	0.227457911111312	0.025078	-1	4.39641775972623	0.025223	1	GO:0005604,basement membrane;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0005614,interstitial matrix	GO:0042802,identical protein binding	GO:0048266,behavioral response to pain;GO:0044267,cellular protein metabolic process;GO:0030198,extracellular matrix organization;GO:0043687,post-translational protein modification	
KTHY_HUMAN	P23919	DTYMK	Thymidylate kinase	0.429136943	1.168132445	0.291113807	0.451714246	0.798634694	0.3714140265	0.798634694	0.3714140265	2.15025453272697	0.208071	0	0.465061221720478	0.207515	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005758,mitochondrial intermembrane space;GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005634,nucleus	GO:0005524,ATP binding;GO:0004550,nucleoside diphosphate kinase activity;GO:0004798,thymidylate kinase activity;GO:0009041,uridylate kinase activity;GO:0016301,kinase activity	GO:0071363,cellular response to growth factor stimulus;GO:0006233,dTDP biosynthetic process;GO:0006235,dTTP biosynthetic process;GO:0006227,dUDP biosynthetic process;GO:0045445,myoblast differentiation;GO:0015949,nucleobase-containing small molecule interconversion;GO:0046686,response to cadmium ion;GO:0043627,response to estrogen;GO:0046105,thymidine biosynthetic process	hsa:1841,path:hsa00240,Pyrimidine metabolism
HBS1L_HUMAN	Q9Y450	HBS1L	HBS1-like protein	0.173787894	0.116512807	0.178067502	0.321922649	0.1451503505	0.2499950755	0.1451503505	0.2499950755	0.580612838911701	0.299265	0	1.7223180973304	0.299554	0	GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0016021,integral component of membrane	GO:0005525,GTP binding;GO:0003924,GTPase activity;GO:0003746,translation elongation factor activity	GO:0043928,exonucleolytic catabolism of deadenylated mRNA;GO:0007165,signal transduction;GO:0006412,translation	hsa:10767,path:hsa03015,mRNA surveillance pathway;hsa:10767,path:hsa05134,Legionellosis
SYDM_HUMAN	Q6PI48	DARS2	Aspartate--tRNA ligase, mitochondrial	0.597085241	0.658214168	1.146182288	4.092174941	0.6276497045	2.6191786145	0.6276497045	2.6191786145	0.239636083245823	0.030127	-1	4.17299426052705	0.030290	1	GO:0005759,mitochondrial matrix;GO:0005739,mitochondrion;GO:0005654,nucleoplasm;GO:0005737,cytoplasm	GO:0004815,aspartate-tRNA ligase activity;GO:0050560,aspartate-tRNA(Asn) ligase activity;GO:0005524,ATP binding;GO:0042803,protein homodimerization activity;GO:0000049,tRNA binding;GO:0004812,aminoacyl-tRNA ligase activity;GO:0003676,nucleic acid binding	GO:0070145,mitochondrial asparaginyl-tRNA aminoacylation;GO:0043039,tRNA aminoacylation;GO:0006418,tRNA aminoacylation for protein translation	hsa:55157,path:hsa00970,Aminoacyl-tRNA biosynthesis
GLNA_HUMAN	P15104	GLUL	Glutamine synthetase	0.874052423	3.654482201	0.741823204	0.157162171	2.264267312	0.4494926875	2.264267312	0.4494926875	5.03738408870111	0.062926	0	0.198515734038031	0.062489	0	GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0070062,extracellular exosome;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0005886,plasma membrane;GO:0043679,axon terminus;GO:0097386,glial cell projection;GO:0043209,myelin sheath;GO:0043204,perikaryon;GO:0032991,protein-containing complex;GO:0005791,rough endoplasmic reticulum	GO:0005524,ATP binding;GO:0004356,glutamate-ammonia ligase activity;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0019706,protein-cysteine S-palmitoyltransferase activity;GO:0045503,dynein light chain binding;GO:0016595,glutamate binding;GO:0000287,magnesium ion binding;GO:0030145,manganese ion binding	GO:0001525,angiogenesis;GO:0008283,cell population proliferation;GO:0006538,glutamate catabolic process;GO:0006542,glutamine biosynthetic process;GO:0009064,glutamine family amino acid metabolic process;GO:0001504,neurotransmitter uptake;GO:0018345,protein palmitoylation;GO:0010594,regulation of endothelial cell migration;GO:1904749,regulation of protein localization to nucleolus;GO:1903670,regulation of sprouting angiogenesis;GO:0042254,ribosome biogenesis;GO:0019676,ammonia assimilation cycle;GO:0009267,cellular response to starvation;GO:0050679,positive regulation of epithelial cell proliferation;GO:0032024,positive regulation of insulin secretion;GO:0051968,positive regulation of synaptic transmission, glutamatergic;GO:0009749,response to glucose	hsa:2752,path:hsa00630,Glyoxylate and dicarboxylate metabolism;hsa:2752,path:hsa00910,Nitrogen metabolism;hsa:2752,path:hsa00250,Alanine, aspartate and glutamate metabolism;hsa:2752,path:hsa00220,Arginine biosynthesis;hsa:2752,path:hsa04217,Necroptosis;hsa:2752,path:hsa04724,Glutamatergic synapse;hsa:2752,path:hsa04727,GABAergic synapse
PRDX6_HUMAN	P30041	PRDX6	Peroxiredoxin-6	20.22147314	50.74678447	21.55798507	33.88052344	35.484128805	27.719254255	35.484128805	27.719254255	1.28012566566791	0.353458	0	0.781173307292643	0.353099	0	GO:0035578,azurophil granule lumen;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0016020,membrane;GO:0005739,mitochondrion;GO:0005634,nucleus;GO:0048471,perinuclear region of cytoplasm	GO:0047184,1-acylglycerophosphocholine O-acyltransferase activity;GO:0045296,cadherin binding;GO:0047499,calcium-independent phospholipase A2 activity;GO:0004602,glutathione peroxidase activity;GO:0042802,identical protein binding;GO:0051920,peroxiredoxin activity;GO:0004623,phospholipase A2 activity;GO:0102567,phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine);GO:0102568,phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine);GO:0031625,ubiquitin protein ligase binding	GO:0045454,cell redox homeostasis;GO:0098869,cellular oxidant detoxification;GO:0034599,cellular response to oxidative stress;GO:0046475,glycerophospholipid catabolic process;GO:0042744,hydrogen peroxide catabolic process;GO:0043312,neutrophil degranulation;GO:0048026,positive regulation of mRNA splicing, via spliceosome;GO:0006979,response to oxidative stress	
PLEC_HUMAN	Q15149	PLEC	Plectin	167.6340135	213.0134718	127.6329906	212.6805936	190.32374265	170.1567921	190.32374265	170.1567921	1.11851980929535	0.396563	0	0.894038703373512	0.396288	0	GO:0005903,brush border;GO:0043034,costamere;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005925,focal adhesion;GO:0030056,hemidesmosome;GO:0045111,intermediate filament cytoskeleton;GO:0016020,membrane;GO:0048471,perinuclear region of cytoplasm;GO:0005886,plasma membrane;GO:0042383,sarcolemma;GO:0016528,sarcoplasm;GO:0005856,cytoskeleton	GO:0003779,actin binding;GO:0030506,ankyrin binding;GO:0045296,cadherin binding;GO:0003723,RNA binding;GO:0005200,structural constituent of cytoskeleton;GO:0008307,structural constituent of muscle;GO:0005198,structural molecule activity	GO:0030199,collagen fibril organization;GO:0031581,hemidesmosome assembly;GO:0045104,intermediate filament cytoskeleton organization;GO:0042060,wound healing	
BIEA_HUMAN	P53004	BLVRA	Biliverdin reductase A	3.983966246	5.764317434	6.203428254	5.260914292	4.87414184	5.732171273	4.87414184	5.732171273	0.850313364319461	0.487564	0	1.17603702583263	0.487486	0	GO:0005829,cytosol;GO:0070062,extracellular exosome	GO:0106276,biliberdin reductase NAD+ activity;GO:0004074,biliverdin reductase (NAD(P)+) activity;GO:0106277,biliverdin reductase (NADP+) activity;GO:0000166,nucleotide binding;GO:0008270,zinc ion binding	GO:0042167,heme catabolic process	hsa:644,path:hsa00860,Porphyrin and chlorophyll metabolism
CMPK2_HUMAN	Q5EBM0	CMPK2	UMP-CMP kinase 2, mitochondrial	0.09751778	0.115999004	0.15211454	2.55E-05	0.106758392	0.07607002	0.106758392	0.07607002	1.4034226887281	0.325092	0	0.712543703355892	0.324682	0	GO:0005737,cytoplasm;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0005524,ATP binding;GO:0036430,CMP kinase activity;GO:0004127,cytidylate kinase activity;GO:0036431,dCMP kinase activity;GO:0004550,nucleoside diphosphate kinase activity;GO:0004798,thymidylate kinase activity;GO:0033862,UMP kinase activity;GO:0009041,uridylate kinase activity	GO:0071222,cellular response to lipopolysaccharide;GO:0006233,dTDP biosynthetic process;GO:0006235,dTTP biosynthetic process;GO:0006227,dUDP biosynthetic process;GO:0006165,nucleoside diphosphate phosphorylation;GO:0009142,nucleoside triphosphate biosynthetic process	hsa:129607,path:hsa00240,Pyrimidine metabolism
CO1A1_HUMAN	P02452	COL1A1	Collagen alpha-1(I) chain	3.702049858	24.61688378	3.860741876	30.49527334	14.159466819	17.178007608	14.159466819	17.178007608	0.824278760501059	0.498018	0	1.21318181168726	0.497963	0	GO:0005584,collagen type I trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005737,cytoplasm;GO:0005788,endoplasmic reticulum lumen;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:0005794,Golgi apparatus;GO:0030141,secretory granule	GO:0005201,extracellular matrix structural constituent;GO:0030020,extracellular matrix structural constituent conferring tensile strength;GO:0042802,identical protein binding;GO:0046872,metal ion binding;GO:0048407,platelet-derived growth factor binding;GO:0002020,protease binding	GO:0007596,blood coagulation;GO:0001568,blood vessel development;GO:0060346,bone trabecula formation;GO:0060351,cartilage development involved in endochondral bone morphogenesis;GO:0071230,cellular response to amino acid stimulus;GO:0071364,cellular response to epidermal growth factor stimulus;GO:0044344,cellular response to fibroblast growth factor stimulus;GO:1902618,cellular response to fluoride;GO:0071260,cellular response to mechanical stimulus;GO:0071300,cellular response to retinoic acid;GO:0071560,cellular response to transforming growth factor beta stimulus;GO:0071356,cellular response to tumor necrosis factor;GO:0071306,cellular response to vitamin E;GO:0032964,collagen biosynthetic process;GO:0030199,collagen fibril organization;GO:0038063,collagen-activated tyrosine kinase receptor signaling pathway;GO:0048706,embryonic skeletal system development;GO:0001958,endochondral ossification;GO:0030198,extracellular matrix organization;GO:0060325,face morphogenesis;GO:0001957,intramembranous ossification;GO:0050900,leukocyte migration;GO:0010812,negative regulation of cell-substrate adhesion;GO:0001503,ossification;GO:0001649,osteoblast differentiation;GO:0030168,platelet activation;GO:0090263,positive regulation of canonical Wnt signaling pathway;GO:0030335,positive regulation of cell migration;GO:0010718,positive regulation of epithelial to mesenchymal transition;GO:0045893,positive regulation of transcription, DNA-templated;GO:0034504,protein localization to nucleus;GO:0015031,protein transport;GO:0050776,regulation of immune response;GO:0051591,response to cAMP;GO:0031960,response to corticosteroid;GO:0042493,response to drug;GO:0032355,response to estradiol;GO:0042542,response to hydrogen peroxide;GO:0055093,response to hyperoxia;GO:0009612,response to mechanical stimulus;GO:0043434,response to peptide hormone;GO:0007605,sensory perception of sound;GO:0001501,skeletal system development;GO:0043588,skin development;GO:0043589,skin morphogenesis;GO:0044691,tooth eruption;GO:0034505,tooth mineralization;GO:0007601,visual perception	hsa:1277,path:hsa04151,PI3K-Akt signaling pathway;hsa:1277,path:hsa04512,ECM-receptor interaction;hsa:1277,path:hsa04510,Focal adhesion;hsa:1277,path:hsa04611,Platelet activation;hsa:1277,path:hsa04926,Relaxin signaling pathway;hsa:1277,path:hsa04974,Protein digestion and absorption;hsa:1277,path:hsa05205,Proteoglycans in cancer;hsa:1277,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:1277,path:hsa05165,Human papillomavirus infection;hsa:1277,path:hsa05146,Amoebiasis
KT3K_HUMAN	Q9HA64	FN3KRP	Ketosamine-3-kinase	0.688325228	0.268332439	0.630568524	0.803576672	0.4783288335	0.717072598	0.4783288335	0.717072598	0.66705774956973	0.376604	0	1.49912057935767	0.376828	0	GO:0005829,cytosol	GO:0005524,ATP binding;GO:0016301,kinase activity;GO:0102193,protein-ribulosamine 3-kinase activity	GO:0043687,post-translational protein modification	
CO6A3_HUMAN	P12111	COL6A3	Collagen alpha-3(VI) chain	150.4370632	160.0312822	184.2754819	1398.841908	155.2341727	791.55869495	155.2341727	791.55869495	0.19611201758046	0.014436	-1	5.09912657234138	0.014536	1	GO:0005589,collagen type VI trimer;GO:0062023,collagen-containing extracellular matrix;GO:0005788,endoplasmic reticulum lumen;GO:0070062,extracellular exosome;GO:0031012,extracellular matrix;GO:0005576,extracellular region;GO:0005615,extracellular space;GO:1903561,extracellular vesicle;GO:0042383,sarcolemma;GO:0005581,collagen trimer	GO:0030020,extracellular matrix structural constituent conferring tensile strength;GO:0004867,serine-type endopeptidase inhibitor activity	GO:0007155,cell adhesion;GO:0030199,collagen fibril organization;GO:0030198,extracellular matrix organization;GO:0007517,muscle organ development	hsa:1293,path:hsa04151,PI3K-Akt signaling pathway;hsa:1293,path:hsa04512,ECM-receptor interaction;hsa:1293,path:hsa04510,Focal adhesion;hsa:1293,path:hsa04974,Protein digestion and absorption;hsa:1293,path:hsa05165,Human papillomavirus infection
EXOC7_HUMAN	Q9UPT5	EXOC7	Exocyst complex component 7	0.341789482	0.390904494	0.605678863	1.256126902	0.366346988	0.9309028825	0.366346988	0.9309028825	0.393539428104628	0.131177	0	2.5410414524822	0.131500	0	GO:0034451,centriolar satellite;GO:0005829,cytosol;GO:0000145,exocyst;GO:0090543,Flemming body;GO:0032584,growth cone membrane;GO:0016020,membrane;GO:0005815,microtubule organizing center;GO:0005886,plasma membrane		GO:0060271,cilium assembly;GO:0006887,exocytosis;GO:0015031,protein transport;GO:2000535,regulation of entry of bacterium into host cell;GO:0016241,regulation of macroautophagy	hsa:23265,path:hsa04910,Insulin signaling pathway;hsa:23265,path:hsa05132,Salmonella infection
CHSP1_HUMAN	Q9Y2V2	CARHSP1	Calcium-regulated heat-stable protein 1	0.677363128	0.747805306	0.143334935	0.076774605	0.712584217	0.11005477	0.712584217	0.11005477	6.47481446737838	0.040732	1	0.154444579846764	0.040382	-1	GO:0005737,cytoplasm;GO:0000177,cytoplasmic exosome (RNase complex);GO:0005829,cytosol;GO:0043186,P granule;GO:0000932,P-body	GO:0003730,mRNA 3'-UTR binding;GO:0019902,phosphatase binding;GO:0003676,nucleic acid binding	GO:0035556,intracellular signal transduction;GO:0043488,regulation of mRNA stability	
DRA_HUMAN	P01903	HLA-DRA	HLA class II histocompatibility antigen, DR alpha chain	5.887038205	9.966751526	15.06014632	13.20357322	7.9268948655	14.13185977	7.9268948655	14.13185977	0.56092368552423	0.281214	0	1.78277371023371	0.281515	0	GO:0009986,cell surface;GO:0031901,early endosome membrane;GO:0012507,ER to Golgi transport vesicle membrane;GO:0009897,external side of plasma membrane;GO:0070062,extracellular exosome;GO:0005615,extracellular space;GO:0000139,Golgi membrane;GO:0071556,integral component of lumenal side of endoplasmic reticulum membrane;GO:0042612,MHC class I protein complex;GO:0032398,MHC class Ib protein complex;GO:0030670,phagocytic vesicle membrane;GO:0005886,plasma membrane;GO:0055038,recycling endosome membrane;GO:0005783,endoplasmic reticulum;GO:0005794,Golgi apparatus;GO:0005887,integral component of plasma membrane;GO:0016020,membrane;GO:0030667,secretory granule membrane;GO:0030669,clathrin-coated endocytic vesicle membrane;GO:0030666,endocytic vesicle membrane;GO:0001772,immunological synapse;GO:0031902,late endosome membrane;GO:0005765,lysosomal membrane;GO:0005764,lysosome;GO:0042613,MHC class II protein complex;GO:0032588,trans-Golgi network membrane;GO:0030658,transport vesicle membrane;GO:0016021,integral component of membrane;GO:0043231,intracellular membrane-bounded organelle;GO:0010008,endosome membrane;GO:0005882,intermediate filament;GO:0070971,endoplasmic reticulum exit site;GO:0005789,endoplasmic reticulum membrane;GO:0005797,Golgi medial cisterna;GO:0042824,MHC class I peptide loading complex;GO:0035577,azurophil granule membrane;GO:0033106,cis-Golgi network membrane;GO:0005769,early endosome;GO:0031527,filopodium membrane;GO:0005771,multivesicular body	GO:0030881,beta-2-microglobulin binding;GO:0042288,MHC class I protein binding;GO:0046703,natural killer cell lectin-like receptor binding;GO:0042605,peptide antigen binding;GO:0005102,signaling receptor binding;GO:0042608,T cell receptor binding;GO:0051087,chaperone binding;GO:0046977,TAP binding;GO:0023026,MHC class II protein complex binding;GO:0032395,MHC class II receptor activity;GO:0030247,polysaccharide binding;GO:0042609,CD4 receptor binding;GO:0005200,structural constituent of cytoskeleton;GO:0042610,CD8 receptor binding;GO:0003723,RNA binding;GO:0062061,TAP complex binding;GO:0071889,14-3-3 protein binding;GO:0046978,TAP1 binding;GO:0046979,TAP2 binding;GO:0042802,identical protein binding;GO:0042803,protein homodimerization activity;GO:1990405,protein antigen binding;GO:0015643,toxic substance binding;GO:0008134,transcription factor binding;GO:0031625,ubiquitin protein ligase binding;GO:0046872,metal ion binding	GO:0002250,adaptive immune response;GO:0019731,antibacterial humoral response;GO:0002476,antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002479,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002480,antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0002477,antigen processing and presentation of exogenous peptide antigen via MHC class Ib;GO:0002474,antigen processing and presentation of peptide antigen via MHC class I;GO:0036037,CD8-positive, alpha-beta T cell activation;GO:0050830,defense response to Gram-positive bacterium;GO:0045087,innate immune response;GO:0060333,interferon-gamma-mediated signaling pathway;GO:0002519,natural killer cell tolerance induction;GO:0045953,negative regulation of natural killer cell mediated cytotoxicity;GO:0001815,positive regulation of antibody-dependent cellular cytotoxicity;GO:2001187,positive regulation of CD8-positive, alpha-beta T cell activation;GO:2000566,positive regulation of CD8-positive, alpha-beta T cell proliferation;GO:0002639,positive regulation of immunoglobulin production;GO:0032736,positive regulation of interleukin-13 production;GO:0032753,positive regulation of interleukin-4 production;GO:0002729,positive regulation of natural killer cell cytokine production;GO:0045954,positive regulation of natural killer cell mediated cytotoxicity;GO:0002717,positive regulation of natural killer cell mediated immunity;GO:0032819,positive regulation of natural killer cell proliferation;GO:0001916,positive regulation of T cell mediated cytotoxicity;GO:0032759,positive regulation of TRAIL production;GO:0032760,positive regulation of tumor necrosis factor production;GO:0042270,protection from natural killer cell mediated cytotoxicity;GO:0050776,regulation of immune response;GO:0002715,regulation of natural killer cell mediated immunity;GO:0060337,type I interferon signaling pathway;GO:0016032,viral process;GO:0002486,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0006952,defense response;GO:0016045,detection of bacterium;GO:0006955,immune response;GO:0043312,neutrophil degranulation;GO:2001198,regulation of dendritic cell differentiation;GO:0032655,regulation of interleukin-12 production;GO:0032675,regulation of interleukin-6 production;GO:0002667,regulation of T cell anergy;GO:0002491,antigen processing and presentation of endogenous peptide antigen via MHC class II;GO:0019886,antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0002504,antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0050890,cognition;GO:0002469,myeloid dendritic cell antigen processing and presentation;GO:0002503,peptide antigen assembly with MHC class II protein complex;GO:2000516,positive regulation of CD4-positive, alpha-beta T cell activation;GO:0032831,positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0043382,positive regulation of memory T cell differentiation;GO:0045622,regulation of T-helper cell differentiation;GO:0050852,T cell receptor signaling pathway;GO:0002399,MHC class II protein complex assembly;GO:2001190,positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0042102,positive regulation of T cell proliferation;GO:0032729,positive regulation of interferon-gamma production;GO:0050870,positive regulation of T cell activation;GO:0008544,epidermis development;GO:0006959,humoral immune response;GO:0002437,inflammatory response to antigenic stimulus;GO:0030225,macrophage differentiation;GO:0002862,negative regulation of inflammatory response to antigenic stimulus;GO:0032689,negative regulation of interferon-gamma production;GO:0042130,negative regulation of T cell proliferation;GO:0070374,positive regulation of ERK1 and ERK2 cascade;GO:0043123,positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0035774,positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0033674,positive regulation of kinase activity;GO:0043410,positive regulation of MAPK cascade;GO:0045657,positive regulation of monocyte differentiation;GO:0001934,positive regulation of protein phosphorylation;GO:0002842,positive regulation of T cell mediated immune response to tumor cell;GO:0045893,positive regulation of transcription, DNA-templated;GO:0046598,positive regulation of viral entry into host cell;GO:0051262,protein tetramerization;GO:0032653,regulation of interleukin-10 production;GO:0032673,regulation of interleukin-4 production;GO:0007165,signal transduction;GO:0042088,T-helper 1 type immune response;GO:0002587,negative regulation of antigen processing and presentation of peptide antigen via MHC class II;GO:0045580,regulation of T cell differentiation;GO:0019885,antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002485,antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent;GO:0042590,antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:2000568,positive regulation of memory T cell activation;GO:0002726,positive regulation of T cell cytokine production;GO:0016567,protein ubiquitination;GO:0001913,T cell mediated cytotoxicity;GO:0002419,T cell mediated cytotoxicity directed against tumor cell target;GO:0002728,negative regulation of natural killer cell cytokine production;GO:0043322,negative regulation of natural killer cell degranulation;GO:1901215,negative regulation of neuron death;GO:0002725,negative regulation of T cell cytokine production;GO:0043323,positive regulation of natural killer cell degranulation;GO:0071346,cellular response to interferon-gamma;GO:0006968,cellular defense response;GO:0002767,immune response-inhibiting cell surface receptor signaling pathway;GO:0016525,negative regulation of angiogenesis;GO:2001199,negative regulation of dendritic cell differentiation;GO:0070317,negative regulation of G0 to G1 transition;GO:0050777,negative regulation of immune response;GO:0051898,negative regulation of protein kinase B signaling;GO:0001915,negative regulation of T cell mediated cytotoxicity;GO:0002451,peripheral B cell tolerance induction;GO:2000774,positive regulation of cellular senescence;GO:2000353,positive regulation of endothelial cell apoptotic process;GO:0032735,positive regulation of interleukin-12 production;GO:0060907,positive regulation of macrophage cytokine production;GO:0045591,positive regulation of regulatory T cell differentiation;GO:0002666,positive regulation of T cell tolerance induction;GO:0002645,positive regulation of tolerance induction;GO:0070207,protein homotrimerization;GO:0019882,antigen processing and presentation;GO:0002344,B cell affinity maturation;GO:0046635,positive regulation of alpha-beta T cell activation;GO:0002579,positive regulation of antigen processing and presentation;GO:0002827,positive regulation of T-helper 1 type immune response	hsa:3133,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3133,path:hsa04144,Endocytosis;hsa:3133,path:hsa04145,Phagosome;hsa:3133,path:hsa04218,Cellular senescence;hsa:3133,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3133,path:hsa04612,Antigen processing and presentation;hsa:3133,path:hsa05203,Viral carcinogenesis;hsa:3133,path:hsa05320,Autoimmune thyroid disease;hsa:3133,path:hsa05330,Allograft rejection;hsa:3133,path:hsa05332,Graft-versus-host disease;hsa:3133,path:hsa05416,Viral myocarditis;hsa:3133,path:hsa04940,Type I diabetes mellitus;hsa:3133,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3133,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3133,path:hsa05168,Herpes simplex virus 1 infection;hsa:3133,path:hsa05163,Human cytomegalovirus infection;hsa:3133,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3133,path:hsa05169,Epstein-Barr virus infection;hsa:3133,path:hsa05165,Human papillomavirus infection;hsa:3106,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3106,path:hsa04144,Endocytosis;hsa:3106,path:hsa04145,Phagosome;hsa:3106,path:hsa04218,Cellular senescence;hsa:3106,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3106,path:hsa04612,Antigen processing and presentation;hsa:3106,path:hsa05203,Viral carcinogenesis;hsa:3106,path:hsa05320,Autoimmune thyroid disease;hsa:3106,path:hsa05330,Allograft rejection;hsa:3106,path:hsa05332,Graft-versus-host disease;hsa:3106,path:hsa05416,Viral myocarditis;hsa:3106,path:hsa04940,Type I diabetes mellitus;hsa:3106,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3106,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3106,path:hsa05168,Herpes simplex virus 1 infection;hsa:3106,path:hsa05163,Human cytomegalovirus infection;hsa:3106,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3106,path:hsa05169,Epstein-Barr virus infection;hsa:3106,path:hsa05165,Human papillomavirus infection;hsa:3122,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3122,path:hsa04145,Phagosome;hsa:3122,path:hsa04640,Hematopoietic cell lineage;hsa:3122,path:hsa04612,Antigen processing and presentation;hsa:3122,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3122,path:hsa04659,Th17 cell differentiation;hsa:3122,path:hsa04672,Intestinal immune network for IgA production;hsa:3122,path:hsa05310,Asthma;hsa:3122,path:hsa05322,Systemic lupus erythematosus;hsa:3122,path:hsa05323,Rheumatoid arthritis;hsa:3122,path:hsa05320,Autoimmune thyroid disease;hsa:3122,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3122,path:hsa05330,Allograft rejection;hsa:3122,path:hsa05332,Graft-versus-host disease;hsa:3122,path:hsa05416,Viral myocarditis;hsa:3122,path:hsa04940,Type I diabetes mellitus;hsa:3122,path:hsa05150,Staphylococcus aureus infection;hsa:3122,path:hsa05152,Tuberculosis;hsa:3122,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3122,path:hsa05164,Influenza A;hsa:3122,path:hsa05168,Herpes simplex virus 1 infection;hsa:3122,path:hsa05169,Epstein-Barr virus infection;hsa:3122,path:hsa05145,Toxoplasmosis;hsa:3122,path:hsa05140,Leishmaniasis;hsa:3109,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3109,path:hsa04145,Phagosome;hsa:3109,path:hsa04640,Hematopoietic cell lineage;hsa:3109,path:hsa04612,Antigen processing and presentation;hsa:3109,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3109,path:hsa04659,Th17 cell differentiation;hsa:3109,path:hsa04672,Intestinal immune network for IgA production;hsa:3109,path:hsa05310,Asthma;hsa:3109,path:hsa05322,Systemic lupus erythematosus;hsa:3109,path:hsa05323,Rheumatoid arthritis;hsa:3109,path:hsa05320,Autoimmune thyroid disease;hsa:3109,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3109,path:hsa05330,Allograft rejection;hsa:3109,path:hsa05332,Graft-versus-host disease;hsa:3109,path:hsa05416,Viral myocarditis;hsa:3109,path:hsa04940,Type I diabetes mellitus;hsa:3109,path:hsa05150,Staphylococcus aureus infection;hsa:3109,path:hsa05152,Tuberculosis;hsa:3109,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3109,path:hsa05164,Influenza A;hsa:3109,path:hsa05168,Herpes simplex virus 1 infection;hsa:3109,path:hsa05169,Epstein-Barr virus infection;hsa:3109,path:hsa05145,Toxoplasmosis;hsa:3109,path:hsa05140,Leishmaniasis;hsa:3115,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3115,path:hsa04145,Phagosome;hsa:3115,path:hsa04640,Hematopoietic cell lineage;hsa:3115,path:hsa04612,Antigen processing and presentation;hsa:3115,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3115,path:hsa04659,Th17 cell differentiation;hsa:3115,path:hsa04672,Intestinal immune network for IgA production;hsa:3115,path:hsa05310,Asthma;hsa:3115,path:hsa05322,Systemic lupus erythematosus;hsa:3115,path:hsa05323,Rheumatoid arthritis;hsa:3115,path:hsa05320,Autoimmune thyroid disease;hsa:3115,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3115,path:hsa05330,Allograft rejection;hsa:3115,path:hsa05332,Graft-versus-host disease;hsa:3115,path:hsa05416,Viral myocarditis;hsa:3115,path:hsa04940,Type I diabetes mellitus;hsa:3115,path:hsa05150,Staphylococcus aureus infection;hsa:3115,path:hsa05152,Tuberculosis;hsa:3115,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3115,path:hsa05164,Influenza A;hsa:3115,path:hsa05168,Herpes simplex virus 1 infection;hsa:3115,path:hsa05169,Epstein-Barr virus infection;hsa:3115,path:hsa05145,Toxoplasmosis;hsa:3115,path:hsa05140,Leishmaniasis;hsa:3123,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3123,path:hsa04145,Phagosome;hsa:3123,path:hsa04640,Hematopoietic cell lineage;hsa:3123,path:hsa04612,Antigen processing and presentation;hsa:3123,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3123,path:hsa04659,Th17 cell differentiation;hsa:3123,path:hsa04672,Intestinal immune network for IgA production;hsa:3123,path:hsa05310,Asthma;hsa:3123,path:hsa05322,Systemic lupus erythematosus;hsa:3123,path:hsa05323,Rheumatoid arthritis;hsa:3123,path:hsa05320,Autoimmune thyroid disease;hsa:3123,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3123,path:hsa05330,Allograft rejection;hsa:3123,path:hsa05332,Graft-versus-host disease;hsa:3123,path:hsa05416,Viral myocarditis;hsa:3123,path:hsa04940,Type I diabetes mellitus;hsa:3123,path:hsa05150,Staphylococcus aureus infection;hsa:3123,path:hsa05152,Tuberculosis;hsa:3123,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3123,path:hsa05164,Influenza A;hsa:3123,path:hsa05168,Herpes simplex virus 1 infection;hsa:3123,path:hsa05169,Epstein-Barr virus infection;hsa:3123,path:hsa05145,Toxoplasmosis;hsa:3123,path:hsa05140,Leishmaniasis;hsa:3111,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3111,path:hsa04145,Phagosome;hsa:3111,path:hsa04640,Hematopoietic cell lineage;hsa:3111,path:hsa04612,Antigen processing and presentation;hsa:3111,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3111,path:hsa04659,Th17 cell differentiation;hsa:3111,path:hsa04672,Intestinal immune network for IgA production;hsa:3111,path:hsa05310,Asthma;hsa:3111,path:hsa05322,Systemic lupus erythematosus;hsa:3111,path:hsa05323,Rheumatoid arthritis;hsa:3111,path:hsa05320,Autoimmune thyroid disease;hsa:3111,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3111,path:hsa05330,Allograft rejection;hsa:3111,path:hsa05332,Graft-versus-host disease;hsa:3111,path:hsa05416,Viral myocarditis;hsa:3111,path:hsa04940,Type I diabetes mellitus;hsa:3111,path:hsa05150,Staphylococcus aureus infection;hsa:3111,path:hsa05152,Tuberculosis;hsa:3111,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3111,path:hsa05164,Influenza A;hsa:3111,path:hsa05168,Herpes simplex virus 1 infection;hsa:3111,path:hsa05169,Epstein-Barr virus infection;hsa:3111,path:hsa05145,Toxoplasmosis;hsa:3111,path:hsa05140,Leishmaniasis;hsa:3112,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3112,path:hsa04145,Phagosome;hsa:3112,path:hsa04640,Hematopoietic cell lineage;hsa:3112,path:hsa04612,Antigen processing and presentation;hsa:3112,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3112,path:hsa04659,Th17 cell differentiation;hsa:3112,path:hsa04672,Intestinal immune network for IgA production;hsa:3112,path:hsa05310,Asthma;hsa:3112,path:hsa05322,Systemic lupus erythematosus;hsa:3112,path:hsa05323,Rheumatoid arthritis;hsa:3112,path:hsa05320,Autoimmune thyroid disease;hsa:3112,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3112,path:hsa05330,Allograft rejection;hsa:3112,path:hsa05332,Graft-versus-host disease;hsa:3112,path:hsa05416,Viral myocarditis;hsa:3112,path:hsa04940,Type I diabetes mellitus;hsa:3112,path:hsa05150,Staphylococcus aureus infection;hsa:3112,path:hsa05152,Tuberculosis;hsa:3112,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3112,path:hsa05164,Influenza A;hsa:3112,path:hsa05168,Herpes simplex virus 1 infection;hsa:3112,path:hsa05169,Epstein-Barr virus infection;hsa:3112,path:hsa05145,Toxoplasmosis;hsa:3112,path:hsa05140,Leishmaniasis;hsa:3105,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3105,path:hsa04144,Endocytosis;hsa:3105,path:hsa04145,Phagosome;hsa:3105,path:hsa04218,Cellular senescence;hsa:3105,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3105,path:hsa04612,Antigen processing and presentation;hsa:3105,path:hsa05203,Viral carcinogenesis;hsa:3105,path:hsa05320,Autoimmune thyroid disease;hsa:3105,path:hsa05330,Allograft rejection;hsa:3105,path:hsa05332,Graft-versus-host disease;hsa:3105,path:hsa05416,Viral myocarditis;hsa:3105,path:hsa04940,Type I diabetes mellitus;hsa:3105,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3105,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3105,path:hsa05168,Herpes simplex virus 1 infection;hsa:3105,path:hsa05163,Human cytomegalovirus infection;hsa:3105,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3105,path:hsa05169,Epstein-Barr virus infection;hsa:3105,path:hsa05165,Human papillomavirus infection;hsa:3134,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3134,path:hsa04144,Endocytosis;hsa:3134,path:hsa04145,Phagosome;hsa:3134,path:hsa04218,Cellular senescence;hsa:3134,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3134,path:hsa04612,Antigen processing and presentation;hsa:3134,path:hsa05203,Viral carcinogenesis;hsa:3134,path:hsa05320,Autoimmune thyroid disease;hsa:3134,path:hsa05330,Allograft rejection;hsa:3134,path:hsa05332,Graft-versus-host disease;hsa:3134,path:hsa05416,Viral myocarditis;hsa:3134,path:hsa04940,Type I diabetes mellitus;hsa:3134,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3134,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3134,path:hsa05168,Herpes simplex virus 1 infection;hsa:3134,path:hsa05163,Human cytomegalovirus infection;hsa:3134,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3134,path:hsa05169,Epstein-Barr virus infection;hsa:3134,path:hsa05165,Human papillomavirus infection;hsa:3119,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3119,path:hsa04145,Phagosome;hsa:3119,path:hsa04640,Hematopoietic cell lineage;hsa:3119,path:hsa04612,Antigen processing and presentation;hsa:3119,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3119,path:hsa04659,Th17 cell differentiation;hsa:3119,path:hsa04672,Intestinal immune network for IgA production;hsa:3119,path:hsa05310,Asthma;hsa:3119,path:hsa05322,Systemic lupus erythematosus;hsa:3119,path:hsa05323,Rheumatoid arthritis;hsa:3119,path:hsa05320,Autoimmune thyroid disease;hsa:3119,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3119,path:hsa05330,Allograft rejection;hsa:3119,path:hsa05332,Graft-versus-host disease;hsa:3119,path:hsa05416,Viral myocarditis;hsa:3119,path:hsa04940,Type I diabetes mellitus;hsa:3119,path:hsa05150,Staphylococcus aureus infection;hsa:3119,path:hsa05152,Tuberculosis;hsa:3119,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3119,path:hsa05164,Influenza A;hsa:3119,path:hsa05168,Herpes simplex virus 1 infection;hsa:3119,path:hsa05169,Epstein-Barr virus infection;hsa:3119,path:hsa05145,Toxoplasmosis;hsa:3119,path:hsa05140,Leishmaniasis;hsa:3113,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3113,path:hsa04145,Phagosome;hsa:3113,path:hsa04640,Hematopoietic cell lineage;hsa:3113,path:hsa04612,Antigen processing and presentation;hsa:3113,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3113,path:hsa04659,Th17 cell differentiation;hsa:3113,path:hsa04672,Intestinal immune network for IgA production;hsa:3113,path:hsa05310,Asthma;hsa:3113,path:hsa05322,Systemic lupus erythematosus;hsa:3113,path:hsa05323,Rheumatoid arthritis;hsa:3113,path:hsa05320,Autoimmune thyroid disease;hsa:3113,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3113,path:hsa05330,Allograft rejection;hsa:3113,path:hsa05332,Graft-versus-host disease;hsa:3113,path:hsa05416,Viral myocarditis;hsa:3113,path:hsa04940,Type I diabetes mellitus;hsa:3113,path:hsa05150,Staphylococcus aureus infection;hsa:3113,path:hsa05152,Tuberculosis;hsa:3113,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3113,path:hsa05164,Influenza A;hsa:3113,path:hsa05168,Herpes simplex virus 1 infection;hsa:3113,path:hsa05169,Epstein-Barr virus infection;hsa:3113,path:hsa05145,Toxoplasmosis;hsa:3113,path:hsa05140,Leishmaniasis;hsa:3125,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3125,path:hsa04145,Phagosome;hsa:3125,path:hsa04640,Hematopoietic cell lineage;hsa:3125,path:hsa04612,Antigen processing and presentation;hsa:3125,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3125,path:hsa04659,Th17 cell differentiation;hsa:3125,path:hsa04672,Intestinal immune network for IgA production;hsa:3125,path:hsa05310,Asthma;hsa:3125,path:hsa05322,Systemic lupus erythematosus;hsa:3125,path:hsa05323,Rheumatoid arthritis;hsa:3125,path:hsa05320,Autoimmune thyroid disease;hsa:3125,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3125,path:hsa05330,Allograft rejection;hsa:3125,path:hsa05332,Graft-versus-host disease;hsa:3125,path:hsa05416,Viral myocarditis;hsa:3125,path:hsa04940,Type I diabetes mellitus;hsa:3125,path:hsa05150,Staphylococcus aureus infection;hsa:3125,path:hsa05152,Tuberculosis;hsa:3125,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3125,path:hsa05164,Influenza A;hsa:3125,path:hsa05168,Herpes simplex virus 1 infection;hsa:3125,path:hsa05169,Epstein-Barr virus infection;hsa:3125,path:hsa05145,Toxoplasmosis;hsa:3125,path:hsa05140,Leishmaniasis;hsa:3126,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3126,path:hsa04145,Phagosome;hsa:3126,path:hsa04640,Hematopoietic cell lineage;hsa:3126,path:hsa04612,Antigen processing and presentation;hsa:3126,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3126,path:hsa04659,Th17 cell differentiation;hsa:3126,path:hsa04672,Intestinal immune network for IgA production;hsa:3126,path:hsa05310,Asthma;hsa:3126,path:hsa05322,Systemic lupus erythematosus;hsa:3126,path:hsa05323,Rheumatoid arthritis;hsa:3126,path:hsa05320,Autoimmune thyroid disease;hsa:3126,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3126,path:hsa05330,Allograft rejection;hsa:3126,path:hsa05332,Graft-versus-host disease;hsa:3126,path:hsa05416,Viral myocarditis;hsa:3126,path:hsa04940,Type I diabetes mellitus;hsa:3126,path:hsa05150,Staphylococcus aureus infection;hsa:3126,path:hsa05152,Tuberculosis;hsa:3126,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3126,path:hsa05164,Influenza A;hsa:3126,path:hsa05168,Herpes simplex virus 1 infection;hsa:3126,path:hsa05169,Epstein-Barr virus infection;hsa:3126,path:hsa05145,Toxoplasmosis;hsa:3126,path:hsa05140,Leishmaniasis;hsa:3107,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3107,path:hsa04144,Endocytosis;hsa:3107,path:hsa04145,Phagosome;hsa:3107,path:hsa04218,Cellular senescence;hsa:3107,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3107,path:hsa04612,Antigen processing and presentation;hsa:3107,path:hsa05203,Viral carcinogenesis;hsa:3107,path:hsa05320,Autoimmune thyroid disease;hsa:3107,path:hsa05330,Allograft rejection;hsa:3107,path:hsa05332,Graft-versus-host disease;hsa:3107,path:hsa05416,Viral myocarditis;hsa:3107,path:hsa04940,Type I diabetes mellitus;hsa:3107,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3107,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3107,path:hsa05168,Herpes simplex virus 1 infection;hsa:3107,path:hsa05163,Human cytomegalovirus infection;hsa:3107,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3107,path:hsa05169,Epstein-Barr virus infection;hsa:3107,path:hsa05165,Human papillomavirus infection;hsa:3135,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3135,path:hsa04144,Endocytosis;hsa:3135,path:hsa04145,Phagosome;hsa:3135,path:hsa04218,Cellular senescence;hsa:3135,path:hsa04650,Natural killer cell mediated cytotoxicity;hsa:3135,path:hsa04612,Antigen processing and presentation;hsa:3135,path:hsa05203,Viral carcinogenesis;hsa:3135,path:hsa05320,Autoimmune thyroid disease;hsa:3135,path:hsa05330,Allograft rejection;hsa:3135,path:hsa05332,Graft-versus-host disease;hsa:3135,path:hsa05416,Viral myocarditis;hsa:3135,path:hsa04940,Type I diabetes mellitus;hsa:3135,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3135,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:3135,path:hsa05168,Herpes simplex virus 1 infection;hsa:3135,path:hsa05163,Human cytomegalovirus infection;hsa:3135,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:3135,path:hsa05169,Epstein-Barr virus infection;hsa:3135,path:hsa05165,Human papillomavirus infection;hsa:3127,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3127,path:hsa04145,Phagosome;hsa:3127,path:hsa04640,Hematopoietic cell lineage;hsa:3127,path:hsa04612,Antigen processing and presentation;hsa:3127,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3127,path:hsa04659,Th17 cell differentiation;hsa:3127,path:hsa04672,Intestinal immune network for IgA production;hsa:3127,path:hsa05310,Asthma;hsa:3127,path:hsa05322,Systemic lupus erythematosus;hsa:3127,path:hsa05323,Rheumatoid arthritis;hsa:3127,path:hsa05320,Autoimmune thyroid disease;hsa:3127,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3127,path:hsa05330,Allograft rejection;hsa:3127,path:hsa05332,Graft-versus-host disease;hsa:3127,path:hsa05416,Viral myocarditis;hsa:3127,path:hsa04940,Type I diabetes mellitus;hsa:3127,path:hsa05150,Staphylococcus aureus infection;hsa:3127,path:hsa05152,Tuberculosis;hsa:3127,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3127,path:hsa05164,Influenza A;hsa:3127,path:hsa05168,Herpes simplex virus 1 infection;hsa:3127,path:hsa05169,Epstein-Barr virus infection;hsa:3127,path:hsa05145,Toxoplasmosis;hsa:3127,path:hsa05140,Leishmaniasis;hsa:3118,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3118,path:hsa04145,Phagosome;hsa:3118,path:hsa04640,Hematopoietic cell lineage;hsa:3118,path:hsa04612,Antigen processing and presentation;hsa:3118,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3118,path:hsa04659,Th17 cell differentiation;hsa:3118,path:hsa04672,Intestinal immune network for IgA production;hsa:3118,path:hsa05310,Asthma;hsa:3118,path:hsa05322,Systemic lupus erythematosus;hsa:3118,path:hsa05323,Rheumatoid arthritis;hsa:3118,path:hsa05320,Autoimmune thyroid disease;hsa:3118,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3118,path:hsa05330,Allograft rejection;hsa:3118,path:hsa05332,Graft-versus-host disease;hsa:3118,path:hsa05416,Viral myocarditis;hsa:3118,path:hsa04940,Type I diabetes mellitus;hsa:3118,path:hsa05150,Staphylococcus aureus infection;hsa:3118,path:hsa05152,Tuberculosis;hsa:3118,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3118,path:hsa05164,Influenza A;hsa:3118,path:hsa05168,Herpes simplex virus 1 infection;hsa:3118,path:hsa05169,Epstein-Barr virus infection;hsa:3118,path:hsa05145,Toxoplasmosis;hsa:3118,path:hsa05140,Leishmaniasis;hsa:3117,path:hsa04514,Cell adhesion molecules (CAMs);hsa:3117,path:hsa04145,Phagosome;hsa:3117,path:hsa04640,Hematopoietic cell lineage;hsa:3117,path:hsa04612,Antigen processing and presentation;hsa:3117,path:hsa04658,Th1 and Th2 cell differentiation;hsa:3117,path:hsa04659,Th17 cell differentiation;hsa:3117,path:hsa04672,Intestinal immune network for IgA production;hsa:3117,path:hsa05310,Asthma;hsa:3117,path:hsa05322,Systemic lupus erythematosus;hsa:3117,path:hsa05323,Rheumatoid arthritis;hsa:3117,path:hsa05320,Autoimmune thyroid disease;hsa:3117,path:hsa05321,Inflammatory bowel disease (IBD);hsa:3117,path:hsa05330,Allograft rejection;hsa:3117,path:hsa05332,Graft-versus-host disease;hsa:3117,path:hsa05416,Viral myocarditis;hsa:3117,path:hsa04940,Type I diabetes mellitus;hsa:3117,path:hsa05150,Staphylococcus aureus infection;hsa:3117,path:hsa05152,Tuberculosis;hsa:3117,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:3117,path:hsa05164,Influenza A;hsa:3117,path:hsa05168,Herpes simplex virus 1 infection;hsa:3117,path:hsa05169,Epstein-Barr virus infection;hsa:3117,path:hsa05145,Toxoplasmosis;hsa:3117,path:hsa05140,Leishmaniasis
KANK2_HUMAN	Q63ZY3	KANK2	KN motif and ankyrin repeat domain-containing protein 2	0.847668186	1.136739787	1.118473194	3.544815524	0.9922039865	2.331644359	0.9922039865	2.331644359	0.425538304188696	0.158322	0	2.34996471564771	0.158655	0	GO:0005737,cytoplasm;GO:0005739,mitochondrion		GO:0006915,apoptotic process;GO:0090521,glomerular visceral epithelial cell migration;GO:0072073,kidney epithelium development;GO:0008285,negative regulation of cell population proliferation;GO:2000134,negative regulation of G1/S transition of mitotic cell cycle;GO:0033147,negative regulation of intracellular estrogen receptor signaling pathway;GO:0043069,negative regulation of programmed cell death;GO:0000122,negative regulation of transcription by RNA polymerase II;GO:0070563,negative regulation of vitamin D receptor signaling pathway;GO:0035023,regulation of Rho protein signal transduction	
IKIP_HUMAN	Q70UQ0	IKBIP	Inhibitor of nuclear factor kappa-B kinase-interacting protein	0.819382805	1.592944605	1.043363465	0.587259618	1.206163705	0.8153115415	1.206163705	0.8153115415	1.47938995537941	0.309264	0	0.675954298840388	0.308828	0	GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0016021,integral component of membrane;GO:0016020,membrane		GO:0010165,response to X-ray	
ABCB6_HUMAN	Q9NP58	ABCB6	ATP-binding cassette sub-family B member 6	0.059042441	0.067167394	0.217395212	0.20315574	0.0631049175	0.210275476	0.0631049175	0.210275476	0.30010593104067	0.062384	0	3.3321567372305	0.062629	0	GO:0043190,ATP-binding cassette (ABC) transporter complex;GO:0005829,cytosol;GO:0031901,early endosome membrane;GO:0036020,endolysosome membrane;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0005768,endosome;GO:0070062,extracellular exosome;GO:0005794,Golgi apparatus;GO:0000139,Golgi membrane;GO:0016021,integral component of membrane;GO:0031307,integral component of mitochondrial outer membrane;GO:0005765,lysosomal membrane;GO:0033162,melanosome membrane;GO:0005740,mitochondrial envelope;GO:0005741,mitochondrial outer membrane;GO:0005739,mitochondrion;GO:0032585,multivesicular body membrane;GO:0005654,nucleoplasm;GO:0005886,plasma membrane;GO:0005774,vacuolar membrane	GO:0015439,ABC-type heme transporter activity;GO:0140359,ABC-type transporter activity;GO:0005524,ATP binding;GO:0016887,ATPase activity;GO:0042626,ATPase-coupled transmembrane transporter activity;GO:0015562,efflux transmembrane transporter activity;GO:0020037,heme binding;GO:0046906,tetrapyrrole binding	GO:0007420,brain development;GO:0006878,cellular copper ion homeostasis;GO:0098849,cellular detoxification of cadmium ion;GO:0006879,cellular iron ion homeostasis;GO:0042168,heme metabolic process;GO:0035351,heme transmembrane transport;GO:0015886,heme transport;GO:1903232,melanosome assembly;GO:0006779,porphyrin-containing compound biosynthetic process;GO:0006778,porphyrin-containing compound metabolic process;GO:0043588,skin development;GO:0033013,tetrapyrrole metabolic process;GO:0055085,transmembrane transport	hsa:10058,path:hsa02010,ABC transporters
PA1B2_HUMAN	P68402	PAFAH1B2	Platelet-activating factor acetylhydrolase IB subunit alpha2	1.155144347	2.925937248	0.650739706	0.455256219	2.0405407975	0.5529979625	2.0405407975	0.5529979625	3.68996078805625	0.102345	0	0.27100558987966	0.101818	0	GO:0008247,1-alkyl-2-acetylglycerophosphocholine esterase complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0070062,extracellular exosome;GO:0005576,extracellular region;GO:0001650,fibrillar center;GO:1904813,ficolin-1-rich granule lumen;GO:0005730,nucleolus;GO:0005886,plasma membrane;GO:0034774,secretory granule lumen	GO:0003847,1-alkyl-2-acetylglycerophosphocholine esterase activity;GO:0047179,platelet-activating factor acetyltransferase activity;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity;GO:0044877,protein-containing complex binding	GO:0007420,brain development;GO:0016042,lipid catabolic process;GO:0006629,lipid metabolic process;GO:0043312,neutrophil degranulation;GO:0016239,positive regulation of macroautophagy;GO:0007283,spermatogenesis	hsa:5049,path:hsa00565,Ether lipid metabolism
WASF2_HUMAN	Q9Y6W5	WASF2	Wiskott-Aldrich syndrome protein family member 2	0.916839613	0.323323099	0.700364235	1.203307235	0.620081356	0.951835735	0.620081356	0.951835735	0.651458369547346	0.362954	0	1.53501750341289	0.363190	0	GO:0015629,actin cytoskeleton;GO:0016323,basolateral plasma membrane;GO:0005911,cell-cell junction;GO:0005829,cytosol;GO:0005769,early endosome;GO:0070062,extracellular exosome;GO:0030027,lamellipodium;GO:0032991,protein-containing complex;GO:0001726,ruffle;GO:0031209,SCAR complex;GO:0045202,synapse	GO:0003779,actin binding;GO:0071933,Arp2/3 complex binding;GO:0045296,cadherin binding;GO:0051018,protein kinase A binding;GO:0034237,protein kinase A regulatory subunit binding;GO:0017124,SH3 domain binding	GO:0030036,actin cytoskeleton organization;GO:0030048,actin filament-based movement;GO:0007188,adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0001667,ameboidal-type cell migration;GO:0001525,angiogenesis;GO:0006897,endocytosis;GO:0038096,Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0030032,lamellipodium assembly;GO:0072673,lamellipodium morphogenesis;GO:0035855,megakaryocyte development;GO:0051497,negative regulation of stress fiber assembly;GO:2000601,positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0010592,positive regulation of lamellipodium assembly;GO:0098974,postsynaptic actin cytoskeleton organization;GO:0016601,Rac protein signal transduction;GO:0048010,vascular endothelial growth factor receptor signaling pathway;GO:0016032,viral process	hsa:10163,path:hsa04520,Adherens junction;hsa:10163,path:hsa04810,Regulation of actin cytoskeleton;hsa:10163,path:hsa04666,Fc gamma R-mediated phagocytosis;hsa:10163,path:hsa05231,Choline metabolism in cancer;hsa:10163,path:hsa05130,Pathogenic Escherichia coli infection;hsa:10163,path:hsa05131,Shigellosis;hsa:10163,path:hsa05135,Yersinia infection;hsa:10163,path:hsa05100,Bacterial invasion of epithelial cells
AN32B_HUMAN	Q92688	ANP32B	Acidic leucine-rich nuclear phosphoprotein 32 family member B	3.810663227	2.350791859	1.207320236	0.300556406	3.080727543	0.753938321	3.080727543	0.753938321	4.08617980700838	0.087825	0	0.244727360818743	0.087324	0	GO:0005737,cytoplasm;GO:0070062,extracellular exosome;GO:0005654,nucleoplasm;GO:0005634,nucleus	GO:0042393,histone binding;GO:0070063,RNA polymerase binding	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0048839,inner ear development;GO:0045596,negative regulation of cell differentiation;GO:0006334,nucleosome assembly;GO:0046827,positive regulation of protein export from nucleus;GO:0042981,regulation of apoptotic process;GO:0060021,roof of mouth development;GO:0001944,vasculature development;GO:0021591,ventricular system development;GO:0016032,viral process	
PKN1_HUMAN	Q16512	PKN1	Serine/threonine-protein kinase N1	0.11246557	0.049458537	0.172082571	0.251109594	0.0809620535	0.2115960825	0.0809620535	0.2115960825	0.382625484098932	0.122248	0	2.61352168519293	0.122565	0	GO:0032154,cleavage furrow;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005768,endosome;GO:0030496,midbody;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0032991,protein-containing complex	GO:0050681,androgen receptor binding;GO:0005524,ATP binding;GO:0004698,calcium-dependent protein kinase C activity;GO:0003682,chromatin binding;GO:0042393,histone binding;GO:0042826,histone deacetylase binding;GO:0035402,histone kinase activity (H3-T11 specific);GO:0030374,nuclear receptor coactivator activity;GO:0004672,protein kinase activity;GO:0004697,protein kinase C activity;GO:0005080,protein kinase C binding;GO:0106310,protein serine kinase activity;GO:0004674,protein serine/threonine kinase activity;GO:0106311,protein threonine kinase activity;GO:0031267,small GTPase binding	GO:0007257,activation of JUN kinase activity;GO:0001783,B cell apoptotic process;GO:0001782,B cell homeostasis;GO:0010631,epithelial cell migration;GO:0035407,histone H3-T11 phosphorylation;GO:0006972,hyperosmotic response;GO:0035556,intracellular signal transduction;GO:0030889,negative regulation of B cell proliferation;GO:0006469,negative regulation of protein kinase activity;GO:0018105,peptidyl-serine phosphorylation;GO:0006468,protein phosphorylation;GO:0060765,regulation of androgen receptor signaling pathway;GO:2000145,regulation of cell motility;GO:0002634,regulation of germinal center formation;GO:0002637,regulation of immunoglobulin production;GO:0006357,regulation of transcription by RNA polymerase II;GO:0003014,renal system process;GO:0007165,signal transduction;GO:0048536,spleen development	hsa:5585,path:hsa04151,PI3K-Akt signaling pathway;hsa:5585,path:hsa04621,NOD-like receptor signaling pathway;hsa:5585,path:hsa05132,Salmonella infection;hsa:5585,path:hsa05135,Yersinia infection
IVD_HUMAN	P26440	IVD	Isovaleryl-CoA dehydrogenase, mitochondrial	1.255547371	2.675906316	3.471059478	2.113207217	1.9657268435	2.7921333475	1.9657268435	2.7921333475	0.70402326782138	0.408274	0	1.42040759972966	0.408466	0	GO:0005759,mitochondrial matrix;GO:0031966,mitochondrial membrane;GO:0005739,mitochondrion;GO:0005654,nucleoplasm	GO:0004085,butyryl-CoA dehydrogenase activity;GO:0050660,flavin adenine dinucleotide binding;GO:0042802,identical protein binding;GO:0008470,isovaleryl-CoA dehydrogenase activity;GO:0003995,acyl-CoA dehydrogenase activity;GO:0016627,oxidoreductase activity, acting on the CH-CH group of donors	GO:0009083,branched-chain amino acid catabolic process;GO:0033539,fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0006552,leucine catabolic process	hsa:3712,path:hsa00280,Valine, leucine and isoleucine degradation
COX5B_HUMAN	P10606	COX5B	Cytochrome c oxidase subunit 5B, mitochondrial	1.465778	2.826203953	1.171489634	0.529153039	2.1459909765	0.8503213365	2.1459909765	0.8503213365	2.52374118393065	0.171533	0	0.396237144429577	0.170963	0	GO:0005743,mitochondrial inner membrane;GO:0005739,mitochondrion	GO:0004129,cytochrome-c oxidase activity;GO:0046872,metal ion binding	GO:0006123,mitochondrial electron transport, cytochrome c to oxygen;GO:0007585,respiratory gaseous exchange by respiratory system	hsa:1329,path:hsa00190,Oxidative phosphorylation;hsa:1329,path:hsa04260,Cardiac muscle contraction;hsa:1329,path:hsa04714,Thermogenesis;hsa:1329,path:hsa05010,Alzheimer disease;hsa:1329,path:hsa05012,Parkinson disease;hsa:1329,path:hsa05016,Huntington disease;hsa:1329,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD)
DAZP1_HUMAN	Q96EP5	DAZAP1	DAZ-associated protein 1	0.436301728	0.348165741	1.076981008	0.252443493	0.3922337345	0.6647122505	0.3922337345	0.6647122505	0.590080496041648	0.307905	0	1.69468404176745	0.308188	0	GO:0005829,cytosol;GO:0005654,nucleoplasm;GO:0032991,protein-containing complex;GO:1990904,ribonucleoprotein complex	GO:0003730,mRNA 3'-UTR binding;GO:0034046,poly(G) binding;GO:0008266,poly(U) RNA binding;GO:0003723,RNA binding;GO:0035613,RNA stem-loop binding	GO:0030154,cell differentiation;GO:0008283,cell population proliferation;GO:0001893,maternal placenta development;GO:0048026,positive regulation of mRNA splicing, via spliceosome;GO:0007283,spermatogenesis	hsa:26528,path:hsa03015,mRNA surveillance pathway
MCA3_HUMAN	O43324	EEF1E1	Eukaryotic translation elongation factor 1 epsilon-1	0.834166765	1.043467986	0.040109951	0.016726332	0.9388173755	0.0284181415	0.9388173755	0.0284181415	33.0358470310242	0.000917	1	0.030270148637657	0.000895	-1	GO:0017101,aminoacyl-tRNA synthetase multienzyme complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005730,nucleolus;GO:0005654,nucleoplasm;GO:0005634,nucleus;GO:0016021,integral component of membrane		GO:0008285,negative regulation of cell population proliferation;GO:0043065,positive regulation of apoptotic process;GO:2000774,positive regulation of cellular senescence;GO:0043517,positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0006418,tRNA aminoacylation for protein translation	
BAX_HUMAN	Q07812	BAX	Apoptosis regulator BAX	2.399455224	3.834286902	0.362107412	0.22471441	3.116871063	0.293410911	3.116871063	0.293410911	10.6228873778999	0.015404	1	0.0941363646648864	0.015213	-1	GO:0097145,BAK complex;GO:0097144,BAX complex;GO:0097136,Bcl-2 family protein complex;GO:0005737,cytoplasm;GO:0005829,cytosol;GO:0005783,endoplasmic reticulum;GO:0005789,endoplasmic reticulum membrane;GO:0070062,extracellular exosome;GO:0016020,membrane;GO:0005741,mitochondrial outer membrane;GO:0005757,mitochondrial permeability transition pore complex;GO:0005739,mitochondrion;GO:0005635,nuclear envelope;GO:0005634,nucleus;GO:0046930,pore complex;GO:0016021,integral component of membrane	GO:0051434,BH3 domain binding;GO:0015267,channel activity;GO:0051087,chaperone binding;GO:0030544,Hsp70 protein binding;GO:0042802,identical protein binding;GO:0008289,lipid binding;GO:0046982,protein heterodimerization activity;GO:0042803,protein homodimerization activity	GO:0006919,activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0008635,activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c;GO:0097296,activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway;GO:0008637,apoptotic mitochondrial changes;GO:0006915,apoptotic process;GO:1902262,apoptotic process involved in blood vessel morphogenesis;GO:1902263,apoptotic process involved in embryonic digit morphogenesis;GO:0097190,apoptotic signaling pathway;GO:0001783,B cell apoptotic process;GO:0001782,B cell homeostasis;GO:0002358,B cell homeostatic proliferation;GO:0002352,B cell negative selection;GO:1990117,B cell receptor apoptotic signaling pathway;GO:0001974,blood vessel remodeling;GO:0034620,cellular response to unfolded protein;GO:0034644,cellular response to UV;GO:0098586,cellular response to virus;GO:0021987,cerebral cortex development;GO:0045136,development of secondary sexual characteristics;GO:0006977,DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0035234,ectopic germ cell programmed cell death;GO:0032469,endoplasmic reticulum calcium ion homeostasis;GO:0010248,establishment or maintenance of transmembrane electrochemical gradient;GO:0097191,extrinsic apoptotic signaling pathway;GO:0097192,extrinsic apoptotic signaling pathway in absence of ligand;GO:0008625,extrinsic apoptotic signaling pathway via death domain receptors;GO:0009566,fertilization;GO:0007281,germ cell development;GO:0006687,glycosphingolipid metabolic process;GO:0048873,homeostasis of number of cells within a tissue;GO:0021854,hypothalamus development;GO:0097193,intrinsic apoptotic signaling pathway;GO:0072332,intrinsic apoptotic signaling pathway by p53 class mediator;GO:0008630,intrinsic apoptotic signaling pathway in response to DNA damage;GO:0070059,intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0001822,kidney development;GO:0043653,mitochondrial fragmentation involved in apoptotic process;GO:0008053,mitochondrial fusion;GO:0070584,mitochondrion morphogenesis;GO:0002262,myeloid cell homeostasis;GO:2001234,negative regulation of apoptotic signaling pathway;GO:0032471,negative regulation of endoplasmic reticulum calcium ion concentration;GO:0048147,negative regulation of fibroblast proliferation;GO:0010917,negative regulation of mitochondrial membrane potential;GO:0043524,negative regulation of neuron apoptotic process;GO:0033137,negative regulation of peptidyl-serine phosphorylation;GO:0032091,negative regulation of protein binding;GO:0051402,neuron apoptotic process;GO:0001764,neuron migration;GO:0042475,odontogenesis of dentin-containing tooth;GO:0001541,ovarian follicle development;GO:1902512,positive regulation of apoptotic DNA fragmentation;GO:0043065,positive regulation of apoptotic process;GO:0060058,positive regulation of apoptotic process involved in mammary gland involution;GO:0002904,positive regulation of B cell apoptotic process;GO:0048087,positive regulation of developmental pigmentation;GO:1900103,positive regulation of endoplasmic reticulum unfolded protein response;GO:2001244,positive regulation of intrinsic apoptotic signaling pathway;GO:1903896,positive regulation of IRE1-mediated unfolded protein response;GO:1901030,positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:0043525,positive regulation of neuron apoptotic process;GO:0031334,positive regulation of protein-containing complex assembly;GO:0090200,positive regulation of release of cytochrome c from mitochondria;GO:0051281,positive regulation of release of sequestered calcium ion into cytosol;GO:0048597,post-embryonic camera-type eye morphogenesis;GO:0001844,protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0042981,regulation of apoptotic process;GO:0033599,regulation of mammary gland epithelial cell proliferation;GO:1902445,regulation of mitochondrial membrane permeability involved in programmed necrotic cell death;GO:0051881,regulation of mitochondrial membrane potential;GO:0006808,regulation of nitrogen utilization;GO:0060260,regulation of transcription initiation from RNA polymerase II promoter;GO:0001836,release of cytochrome c from mitochondria;GO:0032976,release of matrix enzymes from mitochondria;GO:0048678,response to axon injury;GO:0010332,response to gamma radiation;GO:0009651,response to salt stress;GO:0009636,response to toxic substance;GO:0060041,retina development in camera-type eye;GO:0046666,retinal cell programmed cell death;GO:0060011,Sertoli cell proliferation;GO:0048515,spermatid differentiation;GO:0001777,T cell homeostatic proliferation;GO:0070242,thymocyte apoptotic process;GO:0060068,vagina development;GO:0016032,viral process	hsa:581,path:hsa04141,Protein processing in endoplasmic reticulum;hsa:581,path:hsa04071,Sphingolipid signaling pathway;hsa:581,path:hsa04210,Apoptosis;hsa:581,path:hsa04215,Apoptosis - multiple species;hsa:581,path:hsa04217,Necroptosis;hsa:581,path:hsa04115,p53 signaling pathway;hsa:581,path:hsa04722,Neurotrophin signaling pathway;hsa:581,path:hsa04211,Longevity regulating pathway;hsa:581,path:hsa05200,Pathways in cancer;hsa:581,path:hsa05202,Transcriptional misregulation in cancer;hsa:581,path:hsa05203,Viral carcinogenesis;hsa:581,path:hsa05210,Colorectal cancer;hsa:581,path:hsa05212,Pancreatic cancer;hsa:581,path:hsa05225,Hepatocellular carcinoma;hsa:581,path:hsa05226,Gastric cancer;hsa:581,path:hsa05214,Glioma;hsa:581,path:hsa05216,Thyroid cancer;hsa:581,path:hsa05220,Chronic myeloid leukemia;hsa:581,path:hsa05217,Basal cell carcinoma;hsa:581,path:hsa05218,Melanoma;hsa:581,path:hsa05213,Endometrial cancer;hsa:581,path:hsa05224,Breast cancer;hsa:581,path:hsa05222,Small cell lung cancer;hsa:581,path:hsa05223,Non-small cell lung cancer;hsa:581,path:hsa05014,Amyotrophic lateral sclerosis (ALS);hsa:581,path:hsa05016,Huntington disease;hsa:581,path:hsa05020,Prion diseases;hsa:581,path:hsa04932,Non-alcoholic fatty liver disease (NAFLD);hsa:581,path:hsa04933,AGE-RAGE signaling pathway in diabetic complications;hsa:581,path:hsa05130,Pathogenic Escherichia coli infection;hsa:581,path:hsa05132,Salmonella infection;hsa:581,path:hsa05131,Shigellosis;hsa:581,path:hsa05152,Tuberculosis;hsa:581,path:hsa05166,Human T-cell leukemia virus 1 infection;hsa:581,path:hsa05170,Human immunodeficiency virus 1 infection;hsa:581,path:hsa05162,Measles;hsa:581,path:hsa05164,Influenza A;hsa:581,path:hsa05161,Hepatitis B;hsa:581,path:hsa05160,Hepatitis C;hsa:581,path:hsa05168,Herpes simplex virus 1 infection;hsa:581,path:hsa05163,Human cytomegalovirus infection;hsa:581,path:hsa05167,Kaposi sarcoma-associated herpesvirus infection;hsa:581,path:hsa05169,Epstein-Barr virus infection;hsa:581,path:hsa05165,Human papillomavirus infection;hsa:581,path:hsa01521,EGFR tyrosine kinase inhibitor resistance;hsa:581,path:hsa01524,Platinum drug resistance;hsa:581,path:hsa01522,Endocrine resistance