Supplementary File 1. Comparison of tyrosine and serine/threonine kinase activities in HBL1 OVA-specific vs. HBL1 control cells using the chip-based phosphoproteomic PamGene platform. Kinase Uniprot ID Kinase Name Mean Specificity Score Mean Significance Score Mean Final Score Median Final score Mean Kinase Statistic Median Kinase Statistic SD Kinase Statitistic Mean peptide set size P06239 Lck 2.5456131997014 0.477121254719662 3.02273445442106 3.17609125905568 -32.8364066543817 -32.5644982321002 2.52080587982428 29.7777777777778 P12931 Src 1.97660208525958 0.477121254719662 2.45372333997925 3.17609125905568 -24.9060888826531 -26.9360338356584 3.59496598021651 45.4444444444444 P42679 CTK 2.37405008366248 0.477121254719662 2.85117133838214 2.8750612633917 -32.4141332672773 -28.9643119972864 8.29665287358631 32.8888888888889 P08631 HCK 1.34589942008172 0.477121254719662 1.82302067480138 2.47712125471966 -22.5826625717512 -27.7215913782459 6.9818639767266 27.7777777777778 P07947 Yes 1.87742937227051 0.477121254719662 2.35455062699017 2.33099321904142 -32.6620152803421 -31.7338094722984 6.82662680641586 24 P06241 Fyn 1.59280819540487 0.477121254719662 2.06992945012453 1.97197127639976 -34.4860204723412 -32.7587391103603 6.08122599121044 16.3333333333333 P06213 InSR 1.32127028697775 0.477121254719662 1.79839154169741 1.81436342303809 -26.5452059130683 -26.5788514703951 0.99718126028416 26.4444444444444 P51451 BLK 1.31478832367703 0.477121254719662 1.79190957839669 1.56330740233595 -25.9741053964687 -26.0201236882149 2.65564747987139 22.2222222222222 P54764 EphA4 1.01544956392006 0.477121254719662 1.49257081863972 1.51333342737411 -34.5269822247521 -29.3612698172665 8.92746814270873 4.44444444444444 P43405 Syk 0.942563249956463 0.477121254719662 1.41968450467613 1.50399340111996 -19.6932406684445 -19.4143466328545 0.887550924144492 80.5555555555556 P00519 Abl 0.815232379917066 0.477121254719662 1.29235363463673 1.32483291033661 -20.7406685927794 -20.2463426569906 2.12834120223907 52 P35968 KDR 0.79778914167026 0.477121254719662 1.27491039638992 1.21230343171013 -23.4122643609948 -22.296144337827 2.21351013101107 19.8888888888889 P29317 EphA2 0.7632413239277 0.477121254719662 1.24036257864736 1.20760831050175 -25.3768365898491 -22.8387719287433 5.71741654289671 7.22222222222222 Q05397 FAK1 0.667752318312299 0.477121254719662 1.14487357303196 1.1590579197569 -18.5848180845867 -19.4214678747105 3.40844740583391 52.8888888888889 P21709 EphA1 0.604804030560785 0.477121254719662 1.08192528528045 1.1417015775509 -20.3143355579976 -20.9417908020649 6.1498564077533 5.16666666666667 Q13882 Brk 0.755989805619432 0.477121254719662 1.23311106033909 1.12301281557226 -19.5560100030042 -19.5945802637034 0.834915470641552 69.7777777777778 P07948 Lyn 0.585811702287312 0.477121254719662 1.06293295700697 1.02996322337744 -20.0881175872119 -20.4506185920486 1.86794523355233 20.7777777777778 P09619 PDGFR[beta] 0.392744179720526 0.477121254719662 0.869865434440189 1.0268721464003 -16.4121672386295 -19.4267756916934 4.16735274241162 13.7777777777778 P14616 IRR 0.447842187238456 0.477121254719662 0.924963441958118 0.955983171015626 -16.6702832691165 -17.441278439866 2.77372294062856 05.sie P11362 FGFR1 0.502225610588464 0.477121254719662 0.979346865308126 0.943095148663527 -19.0774195175585 -18.4216124381226 1.41236760271264 19.5555555555556 P22455 FGFR4 0.420367691412202 0.477121254719662 0.897488946131865 0.928117992693875 -17.2282704838767 -18.5765880727353 3.75119413108538 23.8888888888889 P21860 HER3 0.460557300812207 0.477121254719662 0.93767855553187 0.916019871070606 -18.2312794251133 -18.3035639703581 1.25472453041573 48.6666666666667 P09769 Fgr 0.459747244037447 0.477121254719662 0.936868498757109 0.911273436046145 -17.5017172581793 -16.4868223698479 2.30278993004772 8.88888888888889 H0Y8A4 RYK 0.396779662466258 0.477121254719662 0.87390091718592 0.877238182645975 -16.0136736902509 -16.2299117910524 2.86442693807031 7.33333333333333 P07333 FmS/CSFR 0.421191329169382 0.477121254719662 0.898312583889044 0.864337397999927 -17.1256482942604 -16.6534391745825 2.12527122108058 9.22222222222222 P43403 ZAP70 0.336210180846998 0.477121254719662 0.81333143556666 0.837634765451076 -17.3848762345216 -17.4370838618202 0.504363465483996 68.6666666666667 P42684 Arg 0.390125497730519 0.477121254719662 0.867246752450182 0.835647144215563 -17.5021536865133 -17.3490779204431 1.43560987763024 51.8888888888889 P29320 EphA3 0.361853099106181 0.477121254719662 0.838974353825843 0.83516323280552 -14.7410628805918 -14.7410628805918 0.562751513509042 5 P00533 EGFR 0.315457203973606 0.477121254719662 0.792578458693269 0.814363423038088 -17.0185748447466 -17.2063051934481 0.911117391042414 49.8888888888889 P08581 Met 0.350038146120377 0.477121254719662 0.827159400840039 0.808735338029662 -17.1680939135082 -16.5183862199588 2.38103919152843 35.2222222222222 P16234 PDGFR[alpha] 0.348270212774491 0.477121254719662 0.825391467494153 0.806875401645538 -14.8213225220505 -14.2938333274617 1.5917453629702 5.88888888888889 P35916 FLT4 0.331686874808998 0.477121254719662 0.80880812952866 0.801342913045577 -15.9412907928075 -15.6077619255507 3.61324691892289 13.7777777777778 P07949 Ret 0.486516510966285 0.477121254719662 0.963637765685948 0.794074216480813 -17.5119629999977 -16.2628596128825 5.04809168637784 19.4444444444444 Q6ZMQ8 Lmr1 0.313373537490114 0.477121254719662 0.790494792209777 0.790484985457369 -12.3294204566441 -12.3294204566441 0 3 Q04912 Ron 0.350626900421988 0.477121254719662 0.82774815514165 0.781639578229465 -15.4635550013165 -15.1354256327284 2.49485777860085 7.22222222222222 Q08345 DDR1 0.296571040692857 0.477121254719662 0.773692295412519 0.771257542435743 -12.3726579242222 -12.3726579242222 0 3 Q14289 FAK2 0.305833282577974 0.477121254719662 0.782954537297636 0.746338979053273 -16.8754514852428 -16.5912515940662 0.942400817818332 39 P29376 LTK 0.228725212988292 0.477121254719662 0.705846467707955 0.738340696235293 -14.0952141847738 -14.7301179287678 2.29963222527568 17.8888888888889 P08069 IGF1R 0.278663032133773 0.477121254719662 0.755784286853435 0.715193416299133 -15.394860615332 -14.8553990036895 1.52956175579057 17.3333333333333 P54760 EphB4 0.21539734511885 0.477121254719662 0.692518599838513 0.692518599838513 -9.75863845293764 -9.75863845293764 0 3 P42685 FRK 0.237581174987891 0.477121254719662 0.714702429707554 0.688952883578495 -16.0711599464563 -15.6526633247233 1.41255885855672 54.6666666666667 P36888 FLT3 0.268892118062916 0.477121254719662 0.746013372782578 0.683836603492243 -14.4584080538369 -13.0490621660031 4.62974669824464 13 P04629 TRKA 0.186614860066034 0.477121254719662 0.663736114785696 0.677780705266081 -13.4738652897648 -13.8034226203729 0.864656798262596 16.6666666666667 P29597 Tyk2 0.200368240281153 0.477121254719662 0.677489495000815 0.67503199683793 -10.6159673945082 -10.6159673945082 0 4 P54756 EphA5 0.162329988888529 0.477121254719662 0.639451243608191 0.664207898076807 -10.2909191110929 -11.3459687037645 1.97782488947422 05.cze P42680 TEC 0.171286711628023 0.477121254719662 0.648407966347686 0.654953175351645 -14.9092972667619 -14.9593854479555 0.843528933989567 40.4444444444444 P41240 CSK 0.177881264054208 0.477121254719662 0.65500251877387 0.643336880063183 -14.9237940216832 -15.4399298683422 2.07609152725346 44.8888888888889 Q16620 TRKB 0.189492009414556 0.477121254719662 0.666613264134218 0.640797139012911 -14.2853899520047 -14.1186339837087 1.19479135360659 25.2222222222222 Q16288 TRKC 0.188270902986899 0.477121254719662 0.665392157706562 0.635761784264808 -14.1837365660214 -14.144938546798 1.23285116406544 23 P21802 FGFR2 0.289455066223932 0.477121254719662 0.766576320943595 0.58838029403677 -14.1152679558309 -10.989437564696 5.29750328807241 13.1111111111111 P42681 TXK 0.0939691358855527 0.477121254719662 0.571090390605215 0.585026652029182 -12.8572596824017 -12.053623124437 1.34654566952918 32.8888888888889 P51813 Etk/BMX 0.0870332558489956 0.477121254719662 0.564154510568658 0.576208186981993 -12.9881533665077 -12.6317547475063 0.853681443504333 34.5555555555556 Q12866 Mer 0.102072646872207 0.477121254719662 0.579193901591869 0.574031267727719 -14.2847605673382 -14.1384469753861 0.863120373912401 54.3333333333333 P04626 HER2 0.0944789482575912 0.477121254719662 0.571600202977254 0.572946886435499 -13.0013591333544 -13.1193542223787 0.799027790678004 33.3333333333333 P54753 EphB3 0.0915149811213502 0.477121254719662 0.568636235841013 0.568636235841013 -7.35767708330769 -7.35767708330769 NA 4 Q9H3Y6 Srm 0.0917022024501679 0.477121254719662 0.56882345716983 0.567565225478487 -13.893689698082 -13.8512669770535 0.252738324176147 44.4444444444444 Q15303 HER4 0.116084133677676 0.477121254719662 0.593205388397338 0.565431095965801 -12.9800079535743 -12.6311459902206 2.08731625778489 31.6666666666667 P10721 Kit 0.0845045388848689 0.477121254719662 0.561625793604531 0.562249437179612 -11.081891677779 -12.2003211834968 2.125155589633 18 Q13308 CCK4/PTK7 0.081336952310535 0.477121254719662 0.558458207030197 0.556016402399447 -7.63675394896751 -7.89441559347101 0.515323289007003 kwi.75 Q9UM73 ALK 0.0699436009960319 0.477121254719662 0.547064855715694 0.544647490042509 -13.5269729461522 -13.5068483590457 0.429696314434634 50.7777777777778 P22607 FGFR3 0.200711613839691 0.477121254719662 0.677832868559353 0.542622803476095 -11.8847596216516 -10.2306821669752 5.40823020579693 12.7777777777778 P29322 EphA8 0.150367087753945 0.477121254719662 0.627488342473608 0.541113083089205 -8.75281108534856 -6.1551803645058 3.86843294356618 4.125 P52333 JAK3 0.0635249419178893 0.477121254719662 0.540646196637552 0.540607512240769 -7.63961602283265 -7.72420837212844 0.100314186149718 5.55555555555556 P16591 Fer 0.047450258617281 0.477121254719662 0.524571513336943 0.526756400343539 -9.50630174450696 -9.84822413657002 0.753092594302157 14.6666666666667 P30530 Axl 0.0789931989885169 0.477121254719662 0.556114453708179 0.525783735923745 -14.1150764143019 -13.6812003263556 1.47081728273877 69 P29323 EphB2 0.0433644125021397 0.477121254719662 0.520485667221802 0.520485667221802 -5.81205866706752 -5.81205866706752 0 4 Q15375 EphA7 0.0602913575480138 0.477121254719662 0.537412612267676 0.519993057042849 -6.40506505015152 -5.97528523970287 0.74440046776438 3.66666666666667 P17948 FLT1 0.0353006166597102 0.477121254719662 0.512421871379373 0.51427857351842 -10.2648527901113 -10.4309577540888 0.474580164239532 21.6666666666667 P54762 EphB1 0.0310511996993511 0.477121254719662 0.508172454419014 0.51304832665267 -5.12291775690971 -5.23134656106624 1.73553274872207 kwi.25 P23458 JAK1~b 0.0289766526842944 0.477121254719662 0.506097907403957 0.507241856073642 -6.2867788339843 -6.60070976139459 0.62786185482058 05.cze O60674 JAK2 0.0172766389490272 0.477121254719662 0.49439789366869 0.499397649430815 -9.08048358785648 -9.80337596916578 1.52339632711344 22.5555555555556 Q06418 Tyro3/Sky 0.0227306893119642 0.477121254719662 0.499851944031627 0.494850021680094 -11.8779514134298 -11.9566443409713 0.421901492153866 49 P07332 Fes 0.0183918428123414 0.477121254719662 0.495513097532004 0.493946182681849 -8.1589276545956 -8.08356262195122 0.492485357944226 14.3333333333333 Q08881 ITK 0.0118242720589755 0.477121254719662 0.488945526778638 0.488562297841047 -10.4803413790848 -10.5994131539732 0.438600745389077 39 Q06187 BTK 0.00203652792611163 0.477121254719662 0.479157782645774 0.477990713432291 -8.00328188002554 -8.07341095311642 0.299318631827453 25 Q92772 CDKL2 1.99901080812711 0.477121254719662 2.47613206284677 2.52557626122369 -8.10312248500808 -8.71812479342125 1.50644184624603 3.33333333333333 P50750 CDK9 1.59738017605901 0.477121254719662 2.07450143077868 2.09691001300806 -3.6540092758664 -3.49998047050411 0.231043208043434 7.66666666666667 Q9BWU1 CDK11 1.60578117587181 0.477121254719662 2.08290243059147 2.09691001300806 -6.06030872714019 -6.06030872714019 0 4 O96017 CHK2 1.3355318997417 0.477121254719662 1.81265315446136 1.81436342303809 1.69982517797663 1.82614963191891 0.20756285369916 20.7777777777778 Q00534 CDK6 1.32767625195207 0.477121254719662 1.80479750667173 1.76111791108486 -4.47025170875156 -4.27149458145298 0.596271381895737 4.88888888888889 Q86V86 Pim3 1.09960893757222 0.410225700127667 1.50983463769989 1.72893322771346 -0.624206139840008 -0.694605481400196 0.210330049159832 56.5555555555556 P11802 CDK4 1.12466456694124 0.477121254719662 1.60178582166091 1.60788953498869 -3.32252057255927 -3.43383410127218 0.333940586138728 6.22222222222222 Q00535 CDK5 0.975142840001884 0.477121254719662 1.45226409472155 1.42790323204948 -2.34580444900619 -2.34580444900619 0 9 Q13535 ATR 0.885027166370888 0.477121254719662 1.36214842109055 1.35654732351381 2.39730319896617 2.33175634895928 0.196640550020683 7.88888888888889 Q05513 PKC[zeta] 0.839962336310998 0.477121254719662 1.31708359103066 1.32483291033661 -1.91376374718758 -2.045673013334 0.261999198179285 10.5555555555556 Q96Q40 PFTAIRE2 0.835667111824355 0.477121254719662 1.31278836654402 1.32483291033661 2.91296933701038 2.74541082242078 0.58582899277602 5.77777777777778 P05771 PKC[beta] 0.799193670726396 0.477121254719662 1.27631492544606 1.2839966563652 -1.77180392346904 -1.77180392346904 0 11 O15075 DCAMKL1 0.751735337732139 0.477121254719662 1.2288565924518 1.20633163274637 2.74421224367055 2.74421224367055 0.261774131461055 04.maj O14757 CHK1 0.723103738986125 0.477121254719662 1.20022499370579 1.20296340545598 1.9561847559248 1.93114605606711 0.0531173734757658 9 Q15131 CDK10 0.775639390922995 0.477121254719662 1.25276064564266 1.18486518336319 2.59556252462451 2.25206197403621 0.876143624866546 6.11111111111111 Q13237 PKG2 0.695425568107154 0.477121254719662 1.17254682282682 1.14266750356873 0.776242675375119 0.793432674833454 0.165701095990742 35 P06493 CDC2/CDK1 0.489529411833921 0.376777922831669 0.866307334665589 1.05551732784983 -1.07957738811628 -1.28068024290343 0.400001214230569 15.3333333333333 Q13131 AMPK[alpha]1 0.640034791473589 0.477121254719662 1.11715604619325 1.05551732784983 1.60514826413696 1.37613237319899 0.317925412776812 10.7777777777778 P68400 CK2[alpha]1 0.567973194736029 0.477121254719662 1.04509444945569 1.04898646069087 -1.55956313680315 -1.55956313680315 0 3 Q8TD08 ERK7 0.571865205971211 0.477121254719662 1.04898646069087 1.04898646069087 1.51273402040194 1.51273402040194 NA 3 O60285 NuaK1 0.573301700221635 0.477121254719662 1.0504229549413 1.04255235068546 -1.58844072302984 -1.49851539149828 0.201079154203776 45872 Q13153 PAK1 0.538454080874776 0.477121254719662 1.01557533559444 1.01472325682071 1.48559822907972 1.48559822907972 0 4 O43293 DAPK3 0.505845405981557 0.477121254719662 0.98296666070122 0.98296666070122 -1.23865173303954 -1.23865173303954 NA 3 P49674 CK1[epsilon] 0.434152181326482 0.477121254719662 0.911273436046145 0.911273436046145 1.12394449737054 1.12394449737054 NA 3 P24723 PKC[eta] 0.51367820082965 0.343330145535671 0.857008346365321 0.901933409792001 -1.23130477745973 -0.915255042705406 0.866086503029049 15 Q8IWB6 SgK307 0.388717206216086 0.477121254719662 0.865838460935748 0.877238182645975 1.01292708186117 1.04971896693808 0.111861055118981 4.11111111111111 Q00532 CDKL1 0.393770440586125 0.38169700377573 0.775467444361855 0.872895201635192 1.07481473892308 1.09435199779001 0.111392341114853 05.cze P23443 p70S6K 0.33977217760066 0.318080836479775 0.657853014080435 0.85802792409292 0.497379342340676 0.806316817964275 0.540372530808563 18.3333333333333 P16066 ANP[alpha] 0.343774901703225 0.477121254719662 0.820896156422887 0.851808803757989 0.634010454034942 0.663154968619802 0.0692475354484053 22.8888888888889 Q00526 CDK3 0.249390940698011 0.410225700127667 0.659616640825678 0.847711655616944 -0.6653484359161 -0.97712361025097 0.488627758692171 11.2222222222222 Q16539 MAPK14 0.38337691474206 0.477121254719662 0.860498169461722 0.84567748570649 -0.409737132900595 -0.838543456473999 0.938156985751649 12.1111111111111 P41743 PKC[iota] 0.378412901507003 0.343330145535671 0.721743047042674 0.831698985370571 -0.925861706568085 -0.878972505251245 0.571581086707056 13.3333333333333 P50613 CDK7 0.331244593927766 0.443673477423665 0.774918071351431 0.805023396783945 -0.881574074548754 -0.823575345143971 0.362531142280874 12.2222222222222 Q13164 ERK5 0.276716215412614 0.376777922831669 0.653494138244282 0.786925174691149 0.131316751524469 0.404715699022911 0.726672288939643 11.8888888888889 O94921 PFTAIRE1 0.310917487041368 0.477121254719662 0.78803874176103 0.783394305796016 0.832459528699379 0.832459528699379 0 3 Q15349 RSK1/p90RSK 0.308578069790497 0.477121254719662 0.78569932451016 0.783394305796016 -0.80613912166641 -0.80613912166641 0 4 P05129 PKC[gamma] 0.347839942193804 0.410225700127667 0.758065642321471 0.781639578229465 -0.832095844152477 -0.745670336334835 0.31870133750462 15.5555555555556 P49840 GSK3[alpha] 0.295596171165534 0.477121254719662 0.772717425885197 0.772970737879863 -0.756800257364749 -0.740736131737129 0.0318762610802875 3.77777777777778 Q05655 PKC[delta] 0.296721192285096 0.443673477423665 0.740394669708761 0.767851293743832 -0.576314050998307 -0.584692295688545 0.040851062542851 22.6666666666667 P28482 ERK2 0.317790640547972 0.343330145535671 0.661120786083642 0.761117911084863 -0.459560905247918 -0.717207560085579 0.714601820292831 16 Q15418 RSK3 0.284527601745859 0.477121254719662 0.761648856465521 0.761117911084863 -0.760315378817008 -0.760315378817008 0 8 O15111 IKK[alpha] 0.279905304125033 0.477121254719662 0.757026558844696 0.755317676427405 0.731734235969941 0.731734235969941 0 3 P49137 MAPKAPK2 0.223088498647199 0.357212227381037 0.580300726028236 0.75448733218585 0.407022948322543 0.478580028447869 0.185820649060162 28.3333333333333 Q16644 MAPKAPK3 0.28655956438725 0.443673477423665 0.730233041810915 0.752845385118873 0.423858663291658 0.400356338510014 0.116453046218859 33 O43930 PRKY 0.268338392905514 0.477121254719662 0.745459647625176 0.72584215073632 0.658361986241278 0.572916042638388 0.190799674307393 10.7777777777778 Q02156 PKC[epsilon] 0.332354423438158 0.376777922831669 0.709132346269827 0.72584215073632 -0.757915064633898 -0.581586397117794 0.359889274943324 18.1111111111111 Q9HBY8 SGK2 0.356174606414891 0.343330145535671 0.699504751950561 0.724304823531391 -0.492777627768676 -0.512518677507176 0.870366329791697 15.3333333333333 P11309 Pim1 0.564463471651629 0.176091259055681 0.740554730707311 0.687540542555237 -0.354646958993933 -0.331765085884753 0.0648252316327455 60.5555555555556 Q15139 PKD1 0.197772564950478 0.477121254719662 0.67489381967014 0.6723005759985 0.547576236515655 0.547576236515655 0 4 P24941 CDK2 0.357774256714029 0.376777922831669 0.734552179545698 0.656263265279962 -0.794538868096548 -0.437526066203341 0.602797217625238 16.5555555555556 Q9UHD2 TBK1 0.139038010411912 0.318080836479775 0.457118846891687 0.605548319173784 0.380759539698952 0.359718958757005 0.0540212028908402 3.88888888888889 P41279 COT 0.11680038678668 0.477121254719662 0.593921641506343 0.590630529547181 -0.315077755790952 -0.315077755790952 0 4 P17612 PKA[alpha] 0.417913788664773 0.309882368239673 0.727796156904446 0.550778808094007 0.357783495264213 0.300782678543039 0.157510745905129 49.1111111111111 Q00537 PCTAIRE2 0.339134521996131 0.176091259055681 0.515225781051812 0.515225781051812 0.903274504074233 0.903274504074233 NA 3 O00141 SGK1 0.316715424674119 0.176091259055681 0.4928066837298 0.496663362443562 -0.84856816422907 -0.84856816422907 0 3 Q9UIK4 DAPK2 0.278376059075477 0.146742715879734 0.425118774955212 0.489488088984207 0.695917841672747 0.787858173736062 0.225206900337169 3.83333333333333 Q9P1W9 Pim2 0.29225896108995 0.223421118197046 0.515680079286995 0.484126156288321 -0.354190738656081 -0.371356682227163 0.10050340222376 39.1111111111111 Q04759 PKC[theta] 0.276867642914228 0.176091259055681 0.452958901969909 0.450179626760633 -0.564969955466008 -0.533026773732575 0.0570930513302356 21.3333333333333 Q96S38 RSKL1 0.254892702348764 0.176091259055681 0.430983961404445 0.429457060118102 -0.654732878112738 -0.654732878112738 0 3 P27361 ERK1 0.228260494720906 0.237303200042412 0.465563694763319 0.427903232049481 0.118193681551338 0.420524967272919 0.590141043993162 17 Q16512 PKN1/PRK1 0.155928783833104 0.0978284772531563 0.253757261086261 0.402304814074488 0.434428189204302 0.625439829399134 0.226665766081211 5.88888888888889 Q9UBS0 p70S6K[beta] 0.28528143030144 0.223421118197046 0.508702548498486 0.400844999315445 0.527091634693586 0.34740103433014 0.56642060672701 23.8888888888889 O75116 ROCK2 0.196157813054709 0.140873007244545 0.337030820299254 0.374002001173949 0.51207171867292 0.548125513018603 0.241658526707022 45812 P51817 PRKX 0.311706938667042 0.203855422746415 0.515562361413457 0.368556230986828 0.273033968498271 0.297605081030809 0.44637929589248 29.2222222222222 P53778 p38[gamma] 0.22192245696603 0.290316672789042 0.512239129755072 0.353923179687664 0.328457747795746 0.466816659806868 0.532927988467098 9.44444444444444 O14920 IKK[beta] 0.146939181409836 0.140873007244545 0.287812188654381 0.351314796580136 -0.369866117562575 -0.484554965653956 0.256452060593474 45691 P31751 Akt2/PKB[beta] 0.154666394312758 0.189973340901048 0.344639735213806 0.329754146925876 0.093965646823132 0.026662302473383 0.130851799484961 25.2222222222222 Q9UKE5 TNIK/ZC2 0.138622877054375 0.176091259055681 0.314714136110056 0.318760438149712 -0.350519097800824 -0.350519097800824 0 3 Q15759 p38[beta] 0.11281262013121 0.140873007244545 0.253685627375755 0.317554061486042 0.292721382189226 0.395098422997705 0.231886781736901 45813 P45984 JNK2 0.209627784550581 0.184289727295783 0.393917511846364 0.313959879742644 -0.511940536528431 -0.35194217531349 0.307576343929486 18 P49841 GSK3[beta] 0.120582347837036 0.176091259055681 0.296673606892717 0.301029995663981 -0.32479052029908 -0.330171058554895 0.0161416147674464 4.88888888888889 P48729 CK1[alpha] 0.135485422938103 0.19817180914115 0.333657232079253 0.299873418464039 0.384791273847068 0.37172661266358 0.127476066136994 10.4444444444444 O15264 p38[delta] 0.262980170351005 0.251185281887779 0.514165452238785 0.29527766677489 0.444643612690837 -0.088781998668468 0.714347921959232 16.4444444444444 P51812 RSK2 0.0860271028762128 0.176091259055681 0.262118361931894 0.261219441515631 0.249335001998877 0.249335001998877 0 7 P31749 Akt1/PKB[alpha] 0.0838327906129184 0.15652556360505 0.240358354217968 0.259111211735299 0.0489938038393543 0.068028411633546 0.196979704543203 26.3333333333333 Q8NI60 ADCK3 0.0583995547719463 0.117394172703788 0.175793727475734 0.233587152887601 0.158306319987269 0.20496215615087 0.124004479990429 9.55555555555556 O75676 MSK2 0.0477314648569097 0.176091259055681 0.223822723912591 0.223783249393556 -0.129939113931432 -0.129939113931432 0 3 Q9Y6S9 RSKL2 0.123021100288605 0.0880456295278406 0.211066729816445 0.208638111806867 0.0634232250710252 0.0634232250710252 0.363377689136263 03.maj Q9UPZ9 ICK 0.124204552767211 0 0.124204552767211 0.1249387366083 -0.360298587615087 -0.360298587615087 0 3 P04049 RAF1 0.108933834188369 0 0.108933834188369 0.0979971086492706 -0.1087614148338 0.146370139702153 0.337899149107795 4.33333333333333 Q13464 ROCK1 0.134936325834552 0.0503117883016232 0.185248114136175 0.0819696632151199 0.201551122656113 0.247698822762577 0.419788810523297 4.71428571428571 O95819 HGK/ZC1 0.0828289472284856 0 0.0828289472284856 0.0809420819148366 -0.22842782652661 -0.231853583396251 0.00839135631345534 3.16666666666667 O76039 CDKL5 0.0902218129144188 0.0440228147639203 0.134244627678339 0.0772822911048133 0.196739820498827 0.212711365988838 0.223415109681253 5.875 P42345 mTOR/FRAP 0.10468010791004 0.0586970863518938 0.163377194261934 0.0757207139381184 0.287258214556532 0.238089345245803 0.266054816674 4.88888888888889 Q14164 IKK[epsilon] 0.115885925979402 0.078262781802525 0.194148707781927 0.0757207139381184 -0.319683901572855 -0.193853732804648 0.153730247706599 5.88888888888889 O75582 MSK1 0.072920433770381 0 0.072920433770381 0.0726296369609765 -0.211156334363065 -0.211156334363065 0 7 Q96GD4 AurB/Aur1 0.0614354341362116 0 0.0614354341362116 0.0457574905606751 0.174789841385827 0.113610891700477 0.119056566895066 4.11111111111111 Q13976 PKG1 0.0909381990168593 0.111710559098523 0.202648758115382 0.0447934624580583 0.134347943968787 0.0452336738529546 0.269797680780003 38.2222222222222 Q96L96 AlphaK1 0.0400312707022144 0 0.0400312707022144 0.0400312707022144 0.109554566759207 0.109554566759207 0 3 P45983 JNK1 0.0497516032902605 0 0.0497516032902605 0.0371573187987575 -0.117535088422113 -0.0868525031800187 0.0764088798318276 23.4444444444444 P53779 JNK3 0.0587766011251027 0 0.0587766011251027 0.0371573187987575 -0.14096052636841 -0.0868525031800187 0.0957072774742904 22.8888888888889 P17252 PKC[alpha] 0.0347809172230908 0 0.0347809172230908 0.0324520237811379 0.0463330802753858 0.0796669607813716 0.0512673936185664 30 O14965 AurA/Aur2 0.0578350895107754 0.0195656954506313 0.0774007849614067 0.0296531237699066 0.159199473799271 0.0926623332074844 0.19961142177536 5.11111111111111 Q16566 CaMK4 0.0205392326761674 0.078262781802525 0.0988020144786924 0.0250280057019311 0.0589609127479307 0.0652177258107116 0.062531277471606 12.3333333333333