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["Supplementary Table 1. Enriched biological processes of CHK2 and the 20 downregulated genes in the HCT116 CHK2 KO cell line "]
["#term ID","term description","observed gene count","background gene count","strength","false discovery rate","matching proteins in your network (IDs)","matching proteins in your network (labels)"]
["GO:0006281","DNA repair",19,522,153,4.54e-22,"9606.ENSP00000013807,9606.ENSP00000251810,9606.ENSP00000254719,9606.ENSP00000262887,9606.ENSP00000263274,9606.ENSP00000269305,9606.ENSP00000301280,9606.ENSP00000305480,9606.ENSP00000307853,9606.ENSP00000313420,9606.ENSP00000323511,9606.ENSP00000336701,9606.ENSP00000361043,9606.ENSP00000369545,9606.ENSP00000372023,9606.ENSP00000372088,9606.ENSP00000382628,9606.ENSP00000406046,9606.ENSP00000482313","ERCC1,RRM2B,RPA1,XRCC1,LIG1,TP53,CHAF1A,FEN1,MUS81,PRKDC,PNKP,RAD51C,RAD54L,NABP2,CHEK2,RAD51,RBBP8,POLD1,RECQL4"]
["GO:0006259","DNA metabolic process",20,750,14,7.95e-22,"9606.ENSP00000013807,9606.ENSP00000251810,9606.ENSP00000254719,9606.ENSP00000258662,9606.ENSP00000262887,9606.ENSP00000263274,9606.ENSP00000269305,9606.ENSP00000301280,9606.ENSP00000305480,9606.ENSP00000307853,9606.ENSP00000313420,9606.ENSP00000323511,9606.ENSP00000336701,9606.ENSP00000361043,9606.ENSP00000369545,9606.ENSP00000372023,9606.ENSP00000372088,9606.ENSP00000382628,9606.ENSP00000406046,9606.ENSP00000482313","ERCC1,RRM2B,RPA1,NUDT15,XRCC1,LIG1,TP53,CHAF1A,FEN1,MUS81,PRKDC,PNKP,RAD51C,RAD54L,NABP2,CHEK2,RAD51,RBBP8,POLD1,RECQL4"]
["GO:0006302","Double-strand break repair",14,204,181,1.02e-17,"9606.ENSP00000013807,9606.ENSP00000254719,9606.ENSP00000262887,9606.ENSP00000269305,9606.ENSP00000305480,9606.ENSP00000307853,9606.ENSP00000313420,9606.ENSP00000336701,9606.ENSP00000361043,9606.ENSP00000369545,9606.ENSP00000372023,9606.ENSP00000372088,9606.ENSP00000382628,9606.ENSP00000482313","ERCC1,RPA1,XRCC1,TP53,FEN1,MUS81,PRKDC,RAD51C,RAD54L,NABP2,CHEK2,RAD51,RBBP8,RECQL4"]
["GO:0006310","DNA recombination",13,219,174,3.1e-15,"9606.ENSP00000013807,9606.ENSP00000254719,9606.ENSP00000262887,9606.ENSP00000263274,9606.ENSP00000305480,9606.ENSP00000307853,9606.ENSP00000313420,9606.ENSP00000336701,9606.ENSP00000361043,9606.ENSP00000369545,9606.ENSP00000372088,9606.ENSP00000382628,9606.ENSP00000482313","ERCC1,RPA1,XRCC1,LIG1,FEN1,MUS81,PRKDC,RAD51C,RAD54L,NABP2,RAD51,RBBP8,RECQL4"]
["GO:0033554","Cellular response to stress",20,1725,103,3.7e-15,"9606.ENSP00000013807,9606.ENSP00000251810,9606.ENSP00000254719,9606.ENSP00000258662,9606.ENSP00000262887,9606.ENSP00000263274,9606.ENSP00000269305,9606.ENSP00000301280,9606.ENSP00000305480,9606.ENSP00000307853,9606.ENSP00000313420,9606.ENSP00000323511,9606.ENSP00000336701,9606.ENSP00000361043,9606.ENSP00000369545,9606.ENSP00000372023,9606.ENSP00000372088,9606.ENSP00000382628,9606.ENSP00000406046,9606.ENSP00000482313","ERCC1,RRM2B,RPA1,NUDT15,XRCC1,LIG1,TP53,CHAF1A,FEN1,MUS81,PRKDC,PNKP,RAD51C,RAD54L,NABP2,CHEK2,RAD51,RBBP8,POLD1,RECQL4"]
["GO:0006139","Nucleobase-containing compound metabolic process",21,2659,87,1.24e-13,"9606.ENSP00000013807,9606.ENSP00000251810,9606.ENSP00000254719,9606.ENSP00000258662,9606.ENSP00000262887,9606.ENSP00000263274,9606.ENSP00000269305,9606.ENSP00000301280,9606.ENSP00000305480,9606.ENSP00000307853,9606.ENSP00000313420,9606.ENSP00000323511,9606.ENSP00000336701,9606.ENSP00000361043,9606.ENSP00000369545,9606.ENSP00000370376,9606.ENSP00000372023,9606.ENSP00000372088,9606.ENSP00000382628,9606.ENSP00000406046,9606.ENSP00000482313","ERCC1,RRM2B,RPA1,NUDT15,XRCC1,LIG1,TP53,CHAF1A,FEN1,MUS81,PRKDC,PNKP,RAD51C,RAD54L,NABP2,DUT,CHEK2,RAD51,RBBP8,POLD1,RECQL4"]
["GO:0000724","Double-strand break repair via homologous recombination",10,102,196,9.68e-13,"9606.ENSP00000254719,9606.ENSP00000262887,9606.ENSP00000305480,9606.ENSP00000307853,9606.ENSP00000336701,9606.ENSP00000361043,9606.ENSP00000369545,9606.ENSP00000372088,9606.ENSP00000382628,9606.ENSP00000482313","RPA1,XRCC1,FEN1,MUS81,RAD51C,RAD54L,NABP2,RAD51,RBBP8,RECQL4"]
["GO:0006260","DNA replication",11,205,17,6.23e-12,"9606.ENSP00000251810,9606.ENSP00000254719,9606.ENSP00000263274,9606.ENSP00000301280,9606.ENSP00000305480,9606.ENSP00000323511,9606.ENSP00000370376,9606.ENSP00000372088,9606.ENSP00000382628,9606.ENSP00000406046,9606.ENSP00000482313","RRM2B,RPA1,LIG1,CHAF1A,FEN1,PNKP,DUT,RAD51,RBBP8,POLD1,RECQL4"]
["GO:0000723","Telomere maintenance",9,112,187,2.15e-10,"9606.ENSP00000013807,9606.ENSP00000254719,9606.ENSP00000262887,9606.ENSP00000305480,9606.ENSP00000313420,9606.ENSP00000336701,9606.ENSP00000372088,9606.ENSP00000406046,9606.ENSP00000482313","ERCC1,RPA1,XRCC1,FEN1,PRKDC,RAD51C,RAD51,POLD1,RECQL4"]
["GO:0007049","Cell cycle",16,1313,106,2.15e-10,"9606.ENSP00000013807,9606.ENSP00000254719,9606.ENSP00000258662,9606.ENSP00000263274,9606.ENSP00000269305,9606.ENSP00000301280,9606.ENSP00000305480,9606.ENSP00000307853,9606.ENSP00000313420,9606.ENSP00000336701,9606.ENSP00000361043,9606.ENSP00000369545,9606.ENSP00000372023,9606.ENSP00000372088,9606.ENSP00000382628,9606.ENSP00000406046","ERCC1,RPA1,NUDT15,LIG1,TP53,CHAF1A,FEN1,MUS81,PRKDC,RAD51C,RAD54L,NABP2,CHEK2,RAD51,RBBP8,POLD1"]
["GO:0022402","Cell cycle process",14,976,113,3.48e-09,"9606.ENSP00000013807,9606.ENSP00000254719,9606.ENSP00000263274,9606.ENSP00000269305,9606.ENSP00000305480,9606.ENSP00000307853,9606.ENSP00000313420,9606.ENSP00000336701,9606.ENSP00000361043,9606.ENSP00000369545,9606.ENSP00000372023,9606.ENSP00000372088,9606.ENSP00000382628,9606.ENSP00000406046","ERCC1,RPA1,LIG1,TP53,FEN1,MUS81,PRKDC,RAD51C,RAD54L,NABP2,CHEK2,RAD51,RBBP8,POLD1"]
["GO:0044260","Cellular macromolecule metabolic process",21,4976,59,2.06e-08,"9606.ENSP00000013807,9606.ENSP00000251810,9606.ENSP00000254719,9606.ENSP00000258662,9606.ENSP00000262887,9606.ENSP00000263274,9606.ENSP00000269305,9606.ENSP00000301280,9606.ENSP00000305480,9606.ENSP00000307853,9606.ENSP00000313420,9606.ENSP00000323511,9606.ENSP00000336701,9606.ENSP00000361043,9606.ENSP00000369545,9606.ENSP00000370376,9606.ENSP00000372023,9606.ENSP00000372088,9606.ENSP00000382628,9606.ENSP00000406046,9606.ENSP00000482313","ERCC1,RRM2B,RPA1,NUDT15,XRCC1,LIG1,TP53,CHAF1A,FEN1,MUS81,PRKDC,PNKP,RAD51C,RAD54L,NABP2,DUT,CHEK2,RAD51,RBBP8,POLD1,RECQL4"]
["GO:0006261","DNA-dependent DNA replication",8,119,18,2.77e-08,"9606.ENSP00000251810,9606.ENSP00000254719,9606.ENSP00000263274,9606.ENSP00000305480,9606.ENSP00000323511,9606.ENSP00000372088,9606.ENSP00000406046,9606.ENSP00000482313","RRM2B,RPA1,LIG1,FEN1,PNKP,RAD51,POLD1,RECQL4"]
["GO:0009314","Response to radiation",10,431,133,4.78e-07,"9606.ENSP00000013807,9606.ENSP00000269305,9606.ENSP00000305480,9606.ENSP00000313420,9606.ENSP00000323511,9606.ENSP00000361043,9606.ENSP00000369545,9606.ENSP00000372023,9606.ENSP00000372088,9606.ENSP00000406046","ERCC1,TP53,FEN1,PRKDC,PNKP,RAD54L,NABP2,CHEK2,RAD51,POLD1"]
["GO:0090305","Nucleic acid phosphodiester bond hydrolysis",9,302,144,7.61e-07,"9606.ENSP00000013807,9606.ENSP00000254719,9606.ENSP00000262887,9606.ENSP00000305480,9606.ENSP00000307853,9606.ENSP00000323511,9606.ENSP00000336701,9606.ENSP00000382628,9606.ENSP00000406046","ERCC1,RPA1,XRCC1,FEN1,MUS81,PNKP,RAD51C,RBBP8,POLD1"]
["GO:0006289","Nucleotide-excision repair",7,111,177,1.34e-06,"9606.ENSP00000013807,9606.ENSP00000254719,9606.ENSP00000262887,9606.ENSP00000263274,9606.ENSP00000269305,9606.ENSP00000323511,9606.ENSP00000406046","ERCC1,RPA1,XRCC1,LIG1,TP53,PNKP,POLD1"]
["GO:0051276","Chromosome organization",12,1066,102,6.18e-06,"9606.ENSP00000013807,9606.ENSP00000254719,9606.ENSP00000262887,9606.ENSP00000269305,9606.ENSP00000301280,9606.ENSP00000305480,9606.ENSP00000313420,9606.ENSP00000336701,9606.ENSP00000361043,9606.ENSP00000372088,9606.ENSP00000406046,9606.ENSP00000482313","ERCC1,RPA1,XRCC1,TP53,CHAF1A,FEN1,PRKDC,RAD51C,RAD54L,RAD51,POLD1,RECQL4"]
["GO:0010212","Response to ionizing radiation",7,145,165,6.94e-06,"9606.ENSP00000013807,9606.ENSP00000269305,9606.ENSP00000313420,9606.ENSP00000361043,9606.ENSP00000369545,9606.ENSP00000372023,9606.ENSP00000372088","ERCC1,TP53,PRKDC,RAD54L,NABP2,CHEK2,RAD51"]
["GO:0034645","Cellular macromolecule biosynthetic process",13,1592,88,3.23e-05,"9606.ENSP00000251810,9606.ENSP00000254719,9606.ENSP00000263274,9606.ENSP00000269305,9606.ENSP00000301280,9606.ENSP00000305480,9606.ENSP00000323511,9606.ENSP00000369545,9606.ENSP00000370376,9606.ENSP00000372088,9606.ENSP00000382628,9606.ENSP00000406046,9606.ENSP00000482313","RRM2B,RPA1,LIG1,TP53,CHAF1A,FEN1,PNKP,NABP2,DUT,RAD51,RBBP8,POLD1,RECQL4"]
["GO:0000278","Mitotic cell cycle",10,695,113,3.39e-05,"9606.ENSP00000254719,9606.ENSP00000258662,9606.ENSP00000263274,9606.ENSP00000269305,9606.ENSP00000307853,9606.ENSP00000313420,9606.ENSP00000369545,9606.ENSP00000372023,9606.ENSP00000372088,9606.ENSP00000382628","RPA1,NUDT15,LIG1,TP53,MUS81,PRKDC,NABP2,CHEK2,RAD51,RBBP8"]
["GO:0006284","Base-excision repair",5,41,206,4.4e-05,"9606.ENSP00000254719,9606.ENSP00000262887,9606.ENSP00000263274,9606.ENSP00000305480,9606.ENSP00000406046","RPA1,XRCC1,LIG1,FEN1,POLD1"]
["GO:0033260","Nuclear dna replication",5,43,203,5.03e-05,"9606.ENSP00000254719,9606.ENSP00000263274,9606.ENSP00000305480,9606.ENSP00000372088,9606.ENSP00000406046","RPA1,LIG1,FEN1,RAD51,POLD1"]
["GO:0000722","Telomere maintenance via recombination",4,12,249,5.96e-05,"9606.ENSP00000013807,9606.ENSP00000262887,9606.ENSP00000336701,9606.ENSP00000372088","ERCC1,XRCC1,RAD51C,RAD51"]
["GO:0051321","Meiotic cell cycle",7,220,147,8.33e-05,"9606.ENSP00000013807,9606.ENSP00000254719,9606.ENSP00000307853,9606.ENSP00000336701,9606.ENSP00000361043,9606.ENSP00000372088,9606.ENSP00000382628","ERCC1,RPA1,MUS81,RAD51C,RAD54L,RAD51,RBBP8"]
["GO:2001020","Regulation of response to dna damage stimulus",7,225,146,9.45e-05,"9606.ENSP00000013807,9606.ENSP00000262887,9606.ENSP00000269305,9606.ENSP00000313420,9606.ENSP00000323511,9606.ENSP00000372023,9606.ENSP00000372088","ERCC1,XRCC1,TP53,PRKDC,PNKP,CHEK2,RAD51"]
["GO:0009628","Response to abiotic stimulus",11,1147,95,0.000171,"9606.ENSP00000013807,9606.ENSP00000262887,9606.ENSP00000269305,9606.ENSP00000305480,9606.ENSP00000313420,9606.ENSP00000323511,9606.ENSP00000361043,9606.ENSP00000369545,9606.ENSP00000372023,9606.ENSP00000372088,9606.ENSP00000406046","ERCC1,XRCC1,TP53,FEN1,PRKDC,PNKP,RAD54L,NABP2,CHEK2,RAD51,POLD1"]
["GO:1903047","Mitotic cell cycle process",9,616,113,0.000189,"9606.ENSP00000254719,9606.ENSP00000263274,9606.ENSP00000269305,9606.ENSP00000307853,9606.ENSP00000313420,9606.ENSP00000369545,9606.ENSP00000372023,9606.ENSP00000372088,9606.ENSP00000382628","RPA1,LIG1,TP53,MUS81,PRKDC,NABP2,CHEK2,RAD51,RBBP8"]
["GO:0006297","Nucleotide-excision repair, dna gap filling",4,23,221,0.000451,"9606.ENSP00000254719,9606.ENSP00000262887,9606.ENSP00000263274,9606.ENSP00000406046","RPA1,XRCC1,LIG1,POLD1"]
["GO:0006283","Transcription-coupled nucleotide-excision repair",5,75,179,0.000508,"9606.ENSP00000013807,9606.ENSP00000254719,9606.ENSP00000262887,9606.ENSP00000263274,9606.ENSP00000406046","ERCC1,RPA1,XRCC1,LIG1,POLD1"]
["GO:1904353","Regulation of telomere capping",4,26,216,0.000675,"9606.ENSP00000013807,9606.ENSP00000262887,9606.ENSP00000323511,9606.ENSP00000369545","ERCC1,XRCC1,PNKP,NABP2"]
["GO:0044249","Cellular biosynthetic process",14,2611,7,0.000677,"9606.ENSP00000251810,9606.ENSP00000254719,9606.ENSP00000258662,9606.ENSP00000263274,9606.ENSP00000269305,9606.ENSP00000301280,9606.ENSP00000305480,9606.ENSP00000323511,9606.ENSP00000369545,9606.ENSP00000370376,9606.ENSP00000372088,9606.ENSP00000382628,9606.ENSP00000406046,9606.ENSP00000482313","RRM2B,RPA1,NUDT15,LIG1,TP53,CHAF1A,FEN1,PNKP,NABP2,DUT,RAD51,RBBP8,POLD1,RECQL4"]
["GO:0006298","Mismatch repair",4,30,209,0.0011,"9606.ENSP00000013807,9606.ENSP00000254719,9606.ENSP00000263274,9606.ENSP00000406046","ERCC1,RPA1,LIG1,POLD1"]
["GO:1901576","Organic substance biosynthetic process",14,2734,68,0.00118,"9606.ENSP00000251810,9606.ENSP00000254719,9606.ENSP00000258662,9606.ENSP00000263274,9606.ENSP00000269305,9606.ENSP00000301280,9606.ENSP00000305480,9606.ENSP00000323511,9606.ENSP00000369545,9606.ENSP00000370376,9606.ENSP00000372088,9606.ENSP00000382628,9606.ENSP00000406046,9606.ENSP00000482313","RRM2B,RPA1,NUDT15,LIG1,TP53,CHAF1A,FEN1,PNKP,NABP2,DUT,RAD51,RBBP8,POLD1,RECQL4"]
["GO:0051054","Positive regulation of dna metabolic process",6,200,145,0.00142,"9606.ENSP00000013807,9606.ENSP00000262887,9606.ENSP00000313420,9606.ENSP00000323511,9606.ENSP00000369545,9606.ENSP00000372088","ERCC1,XRCC1,PRKDC,PNKP,NABP2,RAD51"]
["GO:0051052","Regulation of dna metabolic process",7,360,126,0.00163,"9606.ENSP00000013807,9606.ENSP00000262887,9606.ENSP00000269305,9606.ENSP00000313420,9606.ENSP00000323511,9606.ENSP00000369545,9606.ENSP00000372088","ERCC1,XRCC1,TP53,PRKDC,PNKP,NABP2,RAD51"]
["GO:0032392","DNA geometric change",5,114,161,0.00323,"9606.ENSP00000254719,9606.ENSP00000269305,9606.ENSP00000361043,9606.ENSP00000372088,9606.ENSP00000482313","RPA1,TP53,RAD54L,RAD51,RECQL4"]
["GO:0061982","Meiosis i cell cycle process",5,114,161,0.00323,"9606.ENSP00000013807,9606.ENSP00000307853,9606.ENSP00000336701,9606.ENSP00000361043,9606.ENSP00000372088","ERCC1,MUS81,RAD51C,RAD54L,RAD51"]
["GO:0000733","DNA strand renaturation",3,8,254,0.0038,"9606.ENSP00000269305,9606.ENSP00000361043,9606.ENSP00000482313","TP53,RAD54L,RECQL4"]
["GO:0007131","Reciprocal meiotic recombination",4,53,185,0.00783,"9606.ENSP00000307853,9606.ENSP00000336701,9606.ENSP00000361043,9606.ENSP00000372088","MUS81,RAD51C,RAD54L,RAD51"]
["GO:0034654","Nucleobase-containing compound biosynthetic process",9,995,93,0.00821,"9606.ENSP00000251810,9606.ENSP00000254719,9606.ENSP00000258662,9606.ENSP00000263274,9606.ENSP00000269305,9606.ENSP00000323511,9606.ENSP00000369545,9606.ENSP00000370376,9606.ENSP00000406046","RRM2B,RPA1,NUDT15,LIG1,TP53,PNKP,NABP2,DUT,POLD1"]
["GO:0036297","Interstrand cross-link repair",4,56,182,0.00919,"9606.ENSP00000013807,9606.ENSP00000254719,9606.ENSP00000307853,9606.ENSP00000372088","ERCC1,RPA1,MUS81,RAD51"]