{"text_format":"3","workbook":"xlsx","n_sheets":1,"sheets":["Supplementary Data 7"],"read":"whole","date_system":"1900"}

{"sheet":"Supplementary Data 7","index":0,"n_rows":72,"n_cols":43,"rows_kept":72,"merged":[[0,0,0,10]]}
["Supplementary Data 7. Previous reported traits associated with SNPs at the novel loci.\nThe GWAS-Catalog was interrogated for all variants in 1 MB at either side of the Genome wide variants. The LD(r2)  and distance column indicates the correlation and distance between the sentinel variant and the  genetic variant as reported in the GWAS catalog. R2 lookups were filtered with r2>0.5 and P value of <5x10-8 (and highlighed in green). By removing the filter, all other associations can be displayed. Lower r2/D' and larger distance are more likely to be not linked as a potential mechanism to CAD."]
["LocusID","SNP","R2","D'","Distance (Kb)","hg38","DATE ADDED TO CATALOG","PUBMEDID","FIRST AUTHOR","DATE","JOURNAL","LINK","STUDY","DISEASE/TRAIT","INITIAL SAMPLE SIZE","REPLICATION SAMPLE SIZE","REGION","CHR_ID","CHR_POS","REPORTED GENE(S)","MAPPED_GENE","UPSTREAM_GENE_ID","DOWNSTREAM_GENE_ID","SNP_GENE_IDS","UPSTREAM_GENE_DISTANCE","DOWNSTREAM_GENE_DISTANCE","STRONGEST SNP-RISK ALLELE","SNPS","MERGED","SNP_ID_CURRENT","CONTEXT","INTERGENIC","RISK ALLELE FREQUENCY","P-VALUE","PVALUE_MLOG","P-VALUE (TEXT)","OR or BETA","95% CI (TEXT)","PLATFORM [SNPS PASSING QC]","CNV","MAPPED_TRAIT","MAPPED_TRAIT_URI","STUDY ACCESSION"]
[2,"rs272564",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},{"v":0,"d":"0.000"},44546601,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","1p34.1",1,44546601,"RNF220","RNF220",null,null,55182,null,null,"rs272564-C","rs272564",0,272564,"intron_variant",0,0.28,{"v":5e-21,"d":"5.00E-21"},20.3010299956639,null,0.351,"[0.28-0.42] unit increase","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[2,"rs272570",{"v":0.514917,"d":"0.515"},{"v":0.988764,"d":"0.989"},-6.277,44540324,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","1p34.1",1,44546601,"RNF220","RNF220",null,null,55182,null,null,"rs272564-C","rs272564",0,272564,"intron_variant",0,0.28,{"v":5e-21,"d":"5.00E-21"},20.3010299956639,null,0.351,"[0.28-0.42] unit increase","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[3,"rs12740789",{"v":0.960192,"d":"0.960"},{"v":1,"d":"1.000"},-86.456,72286390,"2013-10-24",23563609,"Wheeler E","2013-04-07","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/23563609","Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.","Obesity (early onset extreme)","1,509 European ancestry cases, 5,380 European ancestry controls","971 European ancestry cases, 1,990 European ancestry controls","1p31.1",1,72372846,"NEGR1","LOC105378797",null,null,105378797,null,null,"rs1993709-G","rs1993709",0,1993709,"intergenic_variant",0,0.81,{"v":5e-13,"d":"5.00E-13"},12.3010299956639,null,1.38,"[1.26-1.50]","Affymetrix [~ 2000000] (imputed)","N","obesity","http://www.ebi.ac.uk/efo/EFO_0001073","GCST001957"]
[3,"rs12740789",{"v":0.83922,"d":"0.839"},{"v":0.957326,"d":"0.957"},-133.208,72286390,"2016-09-28",26604143,"Felix JF","2015-11-24","Hum Mol Genet","www.ncbi.nlm.nih.gov/pubmed/26604143","Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.","Childhood body mass index","34,744 European ancestry children","11,313 European ancestry children","1p31.1",1,72419598,"NEGR1","LOC105378796, LOC105378797",null,null,"105378796, 105378797",null,null,"rs2590942-T","rs2590942",0,2590942,"intergenic_variant",0,0.82,{"v":2e-07,"d":"2.00E-07"},6.69897000433601,null,0.047,"[0.029-0.065] unit increase","Affymetrix, Illumina [2499691] (imputed)","N","body mass index","http://www.ebi.ac.uk/efo/EFO_0004340","GCST003177"]
[3,"rs61765646",{"v":0.889933,"d":"0.890"},{"v":0.943363,"d":"0.943"},-115.318,72257528,"2013-10-24",23563609,"Wheeler E","2013-04-07","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/23563609","Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.","Obesity (early onset extreme)","1,509 European ancestry cases, 5,380 European ancestry controls","971 European ancestry cases, 1,990 European ancestry controls","1p31.1",1,72372846,"NEGR1","LOC105378797",null,null,105378797,null,null,"rs1993709-G","rs1993709",0,1993709,"intergenic_variant",0,0.81,{"v":5e-13,"d":"5.00E-13"},12.3010299956639,null,1.38,"[1.26-1.50]","Affymetrix [~ 2000000] (imputed)","N","obesity","http://www.ebi.ac.uk/efo/EFO_0001073","GCST001957"]
[3,"rs61765646",{"v":0.773584,"d":"0.774"},{"v":0.900647,"d":"0.901"},{"v":-162.07,"d":"-162.070"},72257528,"2016-09-28",26604143,"Felix JF","2015-11-24","Hum Mol Genet","www.ncbi.nlm.nih.gov/pubmed/26604143","Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.","Childhood body mass index","34,744 European ancestry children","11,313 European ancestry children","1p31.1",1,72419598,"NEGR1","LOC105378796, LOC105378797",null,null,"105378796, 105378797",null,null,"rs2590942-T","rs2590942",0,2590942,"intergenic_variant",0,0.82,{"v":2e-07,"d":"2.00E-07"},6.69897000433601,null,0.047,"[0.029-0.065] unit increase","Affymetrix, Illumina [2499691] (imputed)","N","body mass index","http://www.ebi.ac.uk/efo/EFO_0004340","GCST003177"]
[4,"rs12713403",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},-0.039,59779531,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","2p16.1",2,59779570,"BCL11A","RNA5SP94 - MIR4432HG",100873327,106660609,null,84701,579646,"rs12713404-T","rs12713404",0,12713404,"intron_variant",1,0.38,{"v":9e-09,"d":"9.00E-09"},8.04575749056067,null,0.1992,"[0.13-0.27] unit decrease","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[4,"rs13022107",{"v":0.508192,"d":"0.508"},{"v":1,"d":"1.000"},1.561,59781131,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","2p16.1",2,59779570,"BCL11A","RNA5SP94 - MIR4432HG",100873327,106660609,null,84701,579646,"rs12713404-T","rs12713404",0,12713404,"intron_variant",1,0.38,{"v":9e-09,"d":"9.00E-09"},8.04575749056067,null,0.1992,"[0.13-0.27] unit decrease","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[4,"rs1442875",{"v":0.741937,"d":"0.742"},{"v":0.911079,"d":"0.911"},20.201,59799771,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","2p16.1",2,59779570,"BCL11A","RNA5SP94 - MIR4432HG",100873327,106660609,null,84701,579646,"rs12713404-T","rs12713404",0,12713404,"intron_variant",1,0.38,{"v":9e-09,"d":"9.00E-09"},8.04575749056067,null,0.1992,"[0.13-0.27] unit decrease","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[4,"rs1899492",{"v":0.50568,"d":"0.506"},{"v":1,"d":"1.000"},-6.401,59773169,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","2p16.1",2,59779570,"BCL11A","RNA5SP94 - MIR4432HG",100873327,106660609,null,84701,579646,"rs12713404-T","rs12713404",0,12713404,"intron_variant",1,0.38,{"v":9e-09,"d":"9.00E-09"},8.04575749056067,null,0.1992,"[0.13-0.27] unit decrease","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[4,"rs4672317",{"v":0.651319,"d":"0.651"},{"v":0.81143,"d":"0.811"},23.806,59803376,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","2p16.1",2,59779570,"BCL11A","RNA5SP94 - MIR4432HG",100873327,106660609,null,84701,579646,"rs12713404-T","rs12713404",0,12713404,"intron_variant",1,0.38,{"v":9e-09,"d":"9.00E-09"},8.04575749056067,null,0.1992,"[0.13-0.27] unit decrease","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[5,"rs17362588",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},{"v":0,"d":"0.000"},178856319,"2013-08-20",23583979,"den Hoed M","2013-04-14","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/23583979","Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.","Heart rate","85,787 European ancestry individuals, 6,568 Indian Asian ancestry indiviudals","88,823 European ancestry individuals","2q31.2",2,178856319,"CCDC141","CCDC141",null,null,285025,null,null,"rs17362588-A","rs17362588",0,17362588,"missense_variant",0,0.114,{"v":4e-26,"d":"4.00E-26"},25.397940008672,null,0.736,"[0.59-0.89] unit increase","Affymetrix, Illumina [2516789] (imputed)","N","heart rate","http://www.ebi.ac.uk/efo/EFO_0004326","GCST001969"]
[5,"rs17362588",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},-4.191,178856319,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","2q31.2",2,178860510,"CCDC141, TTN","CCDC141",null,null,285025,null,null,"rs151041685-T","rs151041685",0,151041685,"intron_variant",0,0.09,{"v":8e-75,"d":"8.00E-75"},74.096910013008,null,1.0613,"[0.95-1.17] unit increase","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[5,"rs17362588",{"v":0.854551,"d":"0.855"},{"v":0.924419,"d":"0.924"},-65.022,178856319,"2017-07-01",28135244,"Warren HR","2017-01-30","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/28135244","Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.","Diastolic blood pressure","140,886 European ancestry individuals","190,318 European ancestry individuals","2q31.2",2,178921341,"CCDC141","LOC105373766, CCDC141",null,null,"105373766, 285025",null,null,"rs79146658-T","rs79146658",0,79146658,"intron_variant",0,0.91,{"v":2e-10,"d":"2.00E-10"},9.69897000433601,null,0.311,"[0.21-0.41] unit decrease","Affymetrix [~ 9800000] (imputed)","N","diastolic blood pressure","http://www.ebi.ac.uk/efo/EFO_0006336","GCST004280"]
[8,"rs151283",{"v":0.526396,"d":"0.526"},{"v":0.891176,"d":"0.891"},-7.686,123110924,"2015-06-12",25342443,"Lindstrom S","2014-10-24","Nat Commun","www.ncbi.nlm.nih.gov/pubmed/25342443","Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.","Mammographic density (dense area)","7,600 European ancestry individuals","343 European ancestry individuals, 1,472 Old Order Amish individuals, 8,564 individuals","5q23.2",5,123118610,"PRDM6","PRDM6",null,null,93166,null,null,"rs186749-A","rs186749",0,186749,"intron_variant",0,0.28,{"v":3e-07,"d":"3.00E-07"},6.52287874528033,{"$nulls":3},"Affymetrix, Illumina [~ 2500000] (imputed)","N","dense area measurement, mammographic density measurement","http://www.ebi.ac.uk/efo/EFO_0006503, http://www.ebi.ac.uk/efo/EFO_0005941","GCST002667"]
[8,"rs151283",{"v":0.526396,"d":"0.526"},{"v":0.891176,"d":"0.891"},-7.686,123110924,"2015-06-13",25342443,"Lindstrom S","2014-10-24","Nat Commun","www.ncbi.nlm.nih.gov/pubmed/25342443","Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.","Percent mammographic density","7,916 European ancestry individuals","343 European ancestry individuals, 1,472 Old Order Amish individuals, 8,564 individuals","5q23.2",5,123118610,"PRDM6","PRDM6",null,null,93166,null,null,"rs186749-A","rs186749",0,186749,"intron_variant",0,0.28,{"v":3E-9,"d":"3.00E-09"},8.52287874528033,null,0.1,"[0.061-0.139] unit increase","Affymetrix, Illumina [~ 2500000] (imputed)","N","mammographic density percentage, mammographic density measurement","http://www.ebi.ac.uk/efo/EFO_0006502, http://www.ebi.ac.uk/efo/EFO_0005941","GCST002669"]
[11,"rs180238",{"v":0.988676,"d":"0.989"},{"v":1,"d":"1.000"},0.851,93921135,"2013-08-20",23583979,"den Hoed M","2013-04-14","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/23583979","Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.","Heart rate","85,787 European ancestry individuals, 6,568 Indian Asian ancestry indiviudals","88,823 European ancestry individuals","7q21.3",7,93920284,"GNG11","LOC105375402",null,null,105375402,null,null,"rs180242-T","rs180242",0,180242,"upstream_gene_variant",0,0.333,{"v":7e-12,"d":"7.00E-12"},11.1549019599857,null,0.316,"[0.21-0.42] unit increase","Affymetrix, Illumina [2516789] (imputed)","N","heart rate","http://www.ebi.ac.uk/efo/EFO_0004326","GCST001969"]
[11,"rs180238",{"v":0.988676,"d":"0.989"},{"v":1,"d":"1.000"},0.032,93921135,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","7q21.3",7,93921103,"GNGT1, GNG11","LOC105375402",null,null,105375402,null,null,"rs180239-C","rs180239",0,180239,"upstream_gene_variant",0,0.35,{"v":5e-21,"d":"5.00E-21"},20.3010299956639,null,0.326,"[0.26-0.39] unit decrease","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[11,"rs180253",{"v":0.912863999999999,"d":"0.913"},{"v":0.988182,"d":"0.988"},-3.819,93916465,"2013-08-20",23583979,"den Hoed M","2013-04-14","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/23583979","Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.","Heart rate","85,787 European ancestry individuals, 6,568 Indian Asian ancestry indiviudals","88,823 European ancestry individuals","7q21.3",7,93920284,"GNG11","LOC105375402",null,null,105375402,null,null,"rs180242-T","rs180242",0,180242,"upstream_gene_variant",0,0.333,{"v":7e-12,"d":"7.00E-12"},11.1549019599857,null,0.316,"[0.21-0.42] unit increase","Affymetrix, Illumina [2516789] (imputed)","N","heart rate","http://www.ebi.ac.uk/efo/EFO_0004326","GCST001969"]
[11,"rs180253",{"v":0.912863999999999,"d":"0.913"},{"v":0.988182,"d":"0.988"},-4.638,93916465,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","7q21.3",7,93921103,"GNGT1, GNG11","LOC105375402",null,null,105375402,null,null,"rs180239-C","rs180239",0,180239,"upstream_gene_variant",0,0.35,{"v":5e-21,"d":"5.00E-21"},20.3010299956639,null,0.326,"[0.26-0.39] unit decrease","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[12,"rs17883557",{"v":0.925451,"d":"0.925"},{"v":0.991128,"d":"0.991"},41.743,100897329,"2010-09-02",20639392,"Eijgelsheim M","2010-07-16","Hum Mol Genet","www.ncbi.nlm.nih.gov/pubmed/20639392","Genome-wide association analysis identifies multiple loci related to resting heart rate.","Resting heart rate","38,991 European ancestry individuals","NA","7q22.1",7,100855586,"SLC12A9","SLC12A9",null,null,56996,null,null,"rs314370-C","rs314370",0,314370,"non_coding_transcript_exon_variant",0,0.19,{"v":6E-10,"d":"6.00E-10"},9.22184874961635,null,7.6,"[5.23-9.97] ms decrease","Affymetrix, Illumina [~ 2500000] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST000731"]
[12,"rs17883557",{"v":0.991373,"d":"0.991"},{"v":1,"d":"1.000"},8.196,100897329,"2010-09-02",20639392,"Eijgelsheim M","2010-07-16","Hum Mol Genet","www.ncbi.nlm.nih.gov/pubmed/20639392","Genome-wide association analysis identifies multiple loci related to resting heart rate.","Resting heart rate","38,991 European ancestry individuals","NA","7q22.1",7,100889133,"UFSP1","UFSP1",null,null,402682,null,null,"rs12666989-C","rs12666989",0,12666989,"missense_variant",0,0.18,{"v":2E-8,"d":"2.00E-08"},7.69897000433601,null,7,"[4.63-9.37] ms decrease","Affymetrix, Illumina [~ 2500000] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST000731"]
[12,"rs17883557",{"v":0.950023,"d":"0.950"},{"v":1,"d":"1.000"},-2.182,100897329,"2013-08-20",23583979,"den Hoed M","2013-04-14","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/23583979","Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.","Heart rate","85,787 European ancestry individuals, 6,568 Indian Asian ancestry indiviudals","88,823 European ancestry individuals","7q22.1",7,100899511,"ACHE","ACHE - RN7SL549P",43,106481071,null,3378,6780,"rs13245899-G","rs13245899",0,13245899,"upstream_gene_variant",1,0.195,{"v":8e-27,"d":"8.00E-27"},26.096910013008,null,0.447,"[0.34-0.55] unit increase","Affymetrix, Illumina [2516789] (imputed)","N","heart rate","http://www.ebi.ac.uk/efo/EFO_0004326","GCST001969"]
[12,"rs17883557",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},1.591,100897329,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","7q22.1",7,100895738,"UFSP1, SRRT, ACHE, EPHB4, GIGYF1, PCOLCE","ACHE",null,null,43,null,null,"rs17881696-A","rs17881696",0,17881696,"intron_variant",0,0.18,{"v":1E-41,"d":"1.00E-41"},41,null,0.5784,"[0.49-0.66] unit increase","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[12,"rs3757868",{"v":0.933645,"d":"0.934"},{"v":0.991203,"d":"0.991"},29.513,100885099,"2010-09-02",20639392,"Eijgelsheim M","2010-07-16","Hum Mol Genet","www.ncbi.nlm.nih.gov/pubmed/20639392","Genome-wide association analysis identifies multiple loci related to resting heart rate.","Resting heart rate","38,991 European ancestry individuals","NA","7q22.1",7,100855586,"SLC12A9","SLC12A9",null,null,56996,null,null,"rs314370-C","rs314370",0,314370,"non_coding_transcript_exon_variant",0,0.19,{"v":6E-10,"d":"6.00E-10"},9.22184874961635,null,7.6,"[5.23-9.97] ms decrease","Affymetrix, Illumina [~ 2500000] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST000731"]
[12,"rs3757868",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},-4.034,100885099,"2010-09-02",20639392,"Eijgelsheim M","2010-07-16","Hum Mol Genet","www.ncbi.nlm.nih.gov/pubmed/20639392","Genome-wide association analysis identifies multiple loci related to resting heart rate.","Resting heart rate","38,991 European ancestry individuals","NA","7q22.1",7,100889133,"UFSP1","UFSP1",null,null,402682,null,null,"rs12666989-C","rs12666989",0,12666989,"missense_variant",0,0.18,{"v":2E-8,"d":"2.00E-08"},7.69897000433601,null,7,"[4.63-9.37] ms decrease","Affymetrix, Illumina [~ 2500000] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST000731"]
[12,"rs3757868",{"v":0.941552,"d":"0.942"},{"v":0.991228,"d":"0.991"},-14.412,100885099,"2013-08-20",23583979,"den Hoed M","2013-04-14","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/23583979","Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.","Heart rate","85,787 European ancestry individuals, 6,568 Indian Asian ancestry indiviudals","88,823 European ancestry individuals","7q22.1",7,100899511,"ACHE","ACHE - RN7SL549P",43,106481071,null,3378,6780,"rs13245899-G","rs13245899",0,13245899,"upstream_gene_variant",1,0.195,{"v":8e-27,"d":"8.00E-27"},26.096910013008,null,0.447,"[0.34-0.55] unit increase","Affymetrix, Illumina [2516789] (imputed)","N","heart rate","http://www.ebi.ac.uk/efo/EFO_0004326","GCST001969"]
[12,"rs3757868",{"v":0.991373,"d":"0.991"},{"v":1,"d":"1.000"},-10.639,100885099,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","7q22.1",7,100895738,"UFSP1, SRRT, ACHE, EPHB4, GIGYF1, PCOLCE","ACHE",null,null,43,null,null,"rs17881696-A","rs17881696",0,17881696,"intron_variant",0,0.18,{"v":1E-41,"d":"1.00E-41"},41,null,0.5784,"[0.49-0.66] unit increase","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[12,"rs76181418",{"v":0.925451,"d":"0.925"},{"v":0.991128,"d":"0.991"},41.754,100897340,"2010-09-02",20639392,"Eijgelsheim M","2010-07-16","Hum Mol Genet","www.ncbi.nlm.nih.gov/pubmed/20639392","Genome-wide association analysis identifies multiple loci related to resting heart rate.","Resting heart rate","38,991 European ancestry individuals","NA","7q22.1",7,100855586,"SLC12A9","SLC12A9",null,null,56996,null,null,"rs314370-C","rs314370",0,314370,"non_coding_transcript_exon_variant",0,0.19,{"v":6E-10,"d":"6.00E-10"},9.22184874961635,null,7.6,"[5.23-9.97] ms decrease","Affymetrix, Illumina [~ 2500000] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST000731"]
[12,"rs76181418",{"v":0.991373,"d":"0.991"},{"v":1,"d":"1.000"},8.207,100897340,"2010-09-02",20639392,"Eijgelsheim M","2010-07-16","Hum Mol Genet","www.ncbi.nlm.nih.gov/pubmed/20639392","Genome-wide association analysis identifies multiple loci related to resting heart rate.","Resting heart rate","38,991 European ancestry individuals","NA","7q22.1",7,100889133,"UFSP1","UFSP1",null,null,402682,null,null,"rs12666989-C","rs12666989",0,12666989,"missense_variant",0,0.18,{"v":2E-8,"d":"2.00E-08"},7.69897000433601,null,7,"[4.63-9.37] ms decrease","Affymetrix, Illumina [~ 2500000] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST000731"]
[12,"rs76181418",{"v":0.950023,"d":"0.950"},{"v":1,"d":"1.000"},-2.171,100897340,"2013-08-20",23583979,"den Hoed M","2013-04-14","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/23583979","Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.","Heart rate","85,787 European ancestry individuals, 6,568 Indian Asian ancestry indiviudals","88,823 European ancestry individuals","7q22.1",7,100899511,"ACHE","ACHE - RN7SL549P",43,106481071,null,3378,6780,"rs13245899-G","rs13245899",0,13245899,"upstream_gene_variant",1,0.195,{"v":8e-27,"d":"8.00E-27"},26.096910013008,null,0.447,"[0.34-0.55] unit increase","Affymetrix, Illumina [2516789] (imputed)","N","heart rate","http://www.ebi.ac.uk/efo/EFO_0004326","GCST001969"]
[12,"rs76181418",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},1.602,100897340,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","7q22.1",7,100895738,"UFSP1, SRRT, ACHE, EPHB4, GIGYF1, PCOLCE","ACHE",null,null,43,null,null,"rs17881696-A","rs17881696",0,17881696,"intron_variant",0,0.18,{"v":1E-41,"d":"1.00E-41"},41,null,0.5784,"[0.49-0.66] unit increase","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[13,"rs1997571",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},{"v":12.38,"d":"12.380"},116558567,"2012-07-19",22544366,"Ellinor PT","2012-04-29","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/22544366","Meta-analysis identifies six new susceptibility loci for atrial fibrillation.","Atrial fibrillation","6,707 European ancestry cases, 52,426 European ancestry controls","5,381 European ancestry casses, 10,030 European ancestry  controls","7q31.2",7,116546187,"CAV1","CAV1",null,null,857,null,null,"rs3807989-G","rs3807989",0,3807989,"intron_variant",0,0.6,{"v":4e-12,"d":"4.00E-12"},11.397940008672,null,1.11,"[1.09-1.15]","Affymetrix, Illumina [~ 2500000] (imputed)","N","atrial fibrillation","http://www.ebi.ac.uk/efo/EFO_0000275","GCST001499"]
[13,"rs1997571",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},{"v":12.38,"d":"12.380"},116558567,"2010-02-02",20062063,"Holm H","2010-01-10","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/20062063","Several common variants modulate heart rate, PR interval and QRS duration.","Electrocardiographic traits","Up to 12,670 European ancestry individuals","Up to 10,352 European ancestry individuals","7q31.2",7,116546187,"CAV1","CAV1",null,null,857,null,null,"rs3807989-A","rs3807989",0,3807989,"intron_variant",0,0.4,{"v":7e-13,"d":"7.00E-13"},12.1549019599857,"(PR interval)",6.4,"[4.65-8.15] % s.d. increase","Illumina [306060]","N","PR interval","http://www.ebi.ac.uk/efo/EFO_0004462","GCST000561"]
[13,"rs1997571",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},{"v":12.38,"d":"12.380"},116558567,"2010-02-04",20062060,"Pfeufer A","2010-01-10","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/20062060","Genome-wide association study of PR interval.","PR interval","28,517 European ancestry individuals","NA","7q31.2",7,116546187,"CAV1, CAV2","CAV1",null,null,857,null,null,"rs3807989-A","rs3807989",0,3807989,"intron_variant",0,0.4,{"v":4e-28,"d":"4.00E-28"},27.397940008672,null,2.3,"[1.89-2.71] ms increase","Affymetrix, Illumina [~ 2500000] (imputed)","N","PR interval","http://www.ebi.ac.uk/efo/EFO_0004462","GCST000562"]
[13,"rs1997571",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},{"v":12.38,"d":"12.380"},116558567,"2014-11-21",24850809,"Verweij N","2014-05-21","Circ Cardiovasc Genet","www.ncbi.nlm.nih.gov/pubmed/24850809","Genetic determinants of P wave duration and PR segment.","PR segment","16,468 European ancestry individuals","NA","7q31.2",7,116546187,"CAV1, MET","CAV1",null,null,857,null,null,"rs3807989-A","rs3807989",0,3807989,"intron_variant",0,0.435,{"v":5e-12,"d":"5.00E-12"},11.3010299956639,null,1.396,"[1.00-1.79] unit increase","Illumina [2300000] (imputed)","N","PR segment","http://www.ebi.ac.uk/efo/EFO_0005095","GCST002456"]
[13,"rs1997571",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},{"v":7.32,"d":"7.320"},116558567,"2013-01-18",23139255,"Butler AM","2012-11-08","Circ Cardiovasc Genet","www.ncbi.nlm.nih.gov/pubmed/23139255","Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.","PR interval","13,415 African American individuals","NA","7q31.2",7,116551247,"CAV1","CAV1",null,null,857,null,null,"rs11773845-A","rs11773845",0,11773845,"intron_variant",0,0.36,{"v":4e-12,"d":"4.00E-12"},11.397940008672,null,2.29,"[1.64-2.94] unit decrease","Affymetrix, Illumina [2845108] (imputed)","N","PR interval","http://www.ebi.ac.uk/efo/EFO_0004462","GCST001735"]
[13,"rs1997571",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},{"v":12.38,"d":"12.380"},116558567,"2015-05-11",25055868,"Sano M","2014-07-23","Hum Mol Genet","www.ncbi.nlm.nih.gov/pubmed/25055868","Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations.","Electrocardiographic traits","2,994 Japnese ancestry individuals","6,805 Korean ancestry individuals","7q31.2",7,116546187,"CAV1","CAV1",null,null,857,null,null,"rs3807989-A","rs3807989",0,3807989,"intron_variant",0,0.337,{"v":2e-06,"d":"2.00E-06"},5.69897000433601,"(PR)",2.423,"[NR] unit increase","Illumina [~ 2500000]","N","PR interval","http://www.ebi.ac.uk/efo/EFO_0004462","GCST002542"]
[13,"rs1997571",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},{"v":7.32,"d":"7.320"},116558567,"2015-04-01",25035420,"Hong KW","2014-07-17","Hum Mol Genet","www.ncbi.nlm.nih.gov/pubmed/25035420","Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.","PR interval","6,085 Korean ancestry individuals","7,295 Japanese ancestry individuals","7q31.2",7,116551247,"CAV1, CAV2","CAV1",null,null,857,null,null,"rs11773845-C","rs11773845",0,11773845,"intron_variant",0,0.34,{"v":3e-14,"d":"3.00E-14"},13.5228787452803,null,3.21,"[2.39-4.03] unit increase","Affymetrix [2100000] (imputed)","N","PR interval","http://www.ebi.ac.uk/efo/EFO_0004462","GCST002535"]
[13,"rs1997571",{"v":0.51159,"d":"0.512"},{"v":0.872926,"d":"0.873"},{"v":38.66,"d":"38.660"},116558567,"2017-07-10",28416818,"Christophersen IE","2017-04-17","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/28416818","Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.","Prevalent atrial fibrillation","8,656 European ancestry cases, 102,776 European ancestry controls.",null,"7q31.2",7,116519907,"CAV1/2","CAV2 - CAV1",858,857,null,11366,4878,"rs2109514-A","rs2109514",0,2109514,"upstream_gene_variant",1,0.51,{"v":7e-13,"d":"7.00E-13"},12.1549019599857,null,1.15,"1.11-1.19","Affymetrix, Illumina [at least 3187278] (imputed)","N","atrial fibrillation","http://www.ebi.ac.uk/efo/EFO_0000275","GCST004301"]
[13,"rs1997571",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},{"v":7.32,"d":"7.320"},116558567,"2017-07-10",28416818,"Christophersen IE","2017-04-17","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/28416818","Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.","Atrial fibrillation","15,979 European ancestry cases, 102,776 European ancestry controls.","NA","7q31.2",7,116551247,"CAV1/2","CAV1",null,null,857,null,null,"rs11773845-A","rs11773845",0,11773845,"intron_variant",0,0.6,{"v":3e-13,"d":"3.00E-13"},12.5228787452803,null,1.1,"[1.07-1.13]","Affymetrix, Illumina [11795432] (imputed)","N","atrial fibrillation","http://www.ebi.ac.uk/efo/EFO_0000275","GCST004297"]
[13,"rs1997571",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},-0.207,116558567,"2017-07-10",28416818,"Christophersen IE","2017-04-17","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/28416818","Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.","Atrial fibrillation","15,979 European ancestry cases, 102,776 European ancestry controls, 641 African American cases, 5,234 African American controls, 837 Japanese ancestry cases, 3,293 Japanese controls, 277 Hispanic cases, 3,081 Hispanic controls,197 Brazilian ancestry cases, 758 Brazilian ancestry controls.","8,180 Japanese ancestry cases, 28,612 Japanese ancestry controls.","7q31.2",7,116558774,"CAV1/2","CAV1",null,null,857,null,null,"rs1997572-G","rs1997572",0,1997572,"intron_variant",0,0.59,{"v":7e-15,"d":"7.00E-15"},14.1549019599857,null,1.1,"[1.08-1.17]","Affymetrix, Illumina [11795432] (imputed)","N","atrial fibrillation","http://www.ebi.ac.uk/efo/EFO_0000275","GCST004295"]
[13,"rs1997571",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},-0.207,116558567,"2017-07-10",28416818,"Christophersen IE","2017-04-17","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/28416818","Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.","Atrial fibrillation","15,979 European ancestry cases, 102,776 European ancestry controls, 641 African American cases, 5,234 African American controls, 837 Japanese ancestry cases, 3,293 Japanese controls, 277 Hispanic cases, 3,081 Hispanic controls,197 Brazilian ancestry cases, 758 Brazilian ancestry controls.","3,666 cases, 139,852 controls","7q31.2",7,116558774,"CAV1/2","CAV1",null,null,857,null,null,"rs1997572-G","rs1997572",0,1997572,"intron_variant",0,0.59,{"v":5e-09,"d":"5.00E-09"},8.30102999566398,null,1.16,"[1.11-1.22]","Affymetrix, Illumina [11795432] (imputed)","N","atrial fibrillation","http://www.ebi.ac.uk/efo/EFO_0000275","GCST004296"]
[13,"rs2109514",{"v":0.51159,"d":"0.512"},{"v":0.872926,"d":"0.873"},{"v":-26.28,"d":"-26.280"},116519907,"2012-07-19",22544366,"Ellinor PT","2012-04-29","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/22544366","Meta-analysis identifies six new susceptibility loci for atrial fibrillation.","Atrial fibrillation","6,707 European ancestry cases, 52,426 European ancestry controls","5,381 European ancestry casses, 10,030 European ancestry  controls","7q31.2",7,116546187,"CAV1","CAV1",null,null,857,null,null,"rs3807989-G","rs3807989",0,3807989,"intron_variant",0,0.6,{"v":4e-12,"d":"4.00E-12"},11.397940008672,null,1.11,"[1.09-1.15]","Affymetrix, Illumina [~ 2500000] (imputed)","N","atrial fibrillation","http://www.ebi.ac.uk/efo/EFO_0000275","GCST001499"]
[13,"rs2109514",{"v":0.51159,"d":"0.512"},{"v":0.872926,"d":"0.873"},{"v":-26.28,"d":"-26.280"},116519907,"2010-02-02",20062063,"Holm H","2010-01-10","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/20062063","Several common variants modulate heart rate, PR interval and QRS duration.","Electrocardiographic traits","Up to 12,670 European ancestry individuals","Up to 10,352 European ancestry individuals","7q31.2",7,116546187,"CAV1","CAV1",null,null,857,null,null,"rs3807989-A","rs3807989",0,3807989,"intron_variant",0,0.4,{"v":7e-13,"d":"7.00E-13"},12.1549019599857,"(PR interval)",6.4,"[4.65-8.15] % s.d. increase","Illumina [306060]","N","PR interval","http://www.ebi.ac.uk/efo/EFO_0004462","GCST000561"]
[13,"rs2109514",{"v":0.51159,"d":"0.512"},{"v":0.872926,"d":"0.873"},{"v":-26.28,"d":"-26.280"},116519907,"2010-02-04",20062060,"Pfeufer A","2010-01-10","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/20062060","Genome-wide association study of PR interval.","PR interval","28,517 European ancestry individuals","NA","7q31.2",7,116546187,"CAV1, CAV2","CAV1",null,null,857,null,null,"rs3807989-A","rs3807989",0,3807989,"intron_variant",0,0.4,{"v":4e-28,"d":"4.00E-28"},27.397940008672,null,2.3,"[1.89-2.71] ms increase","Affymetrix, Illumina [~ 2500000] (imputed)","N","PR interval","http://www.ebi.ac.uk/efo/EFO_0004462","GCST000562"]
[13,"rs2109514",{"v":0.51159,"d":"0.512"},{"v":0.872926,"d":"0.873"},{"v":-26.28,"d":"-26.280"},116519907,"2014-11-21",24850809,"Verweij N","2014-05-21","Circ Cardiovasc Genet","www.ncbi.nlm.nih.gov/pubmed/24850809","Genetic determinants of P wave duration and PR segment.","PR segment","16,468 European ancestry individuals","NA","7q31.2",7,116546187,"CAV1, MET","CAV1",null,null,857,null,null,"rs3807989-A","rs3807989",0,3807989,"intron_variant",0,0.435,{"v":5e-12,"d":"5.00E-12"},11.3010299956639,null,1.396,"[1.00-1.79] unit increase","Illumina [2300000] (imputed)","N","PR segment","http://www.ebi.ac.uk/efo/EFO_0005095","GCST002456"]
[13,"rs2109514",{"v":0.51159,"d":"0.512"},{"v":0.872926,"d":"0.873"},{"v":-31.34,"d":"-31.340"},116519907,"2013-01-18",23139255,"Butler AM","2012-11-08","Circ Cardiovasc Genet","www.ncbi.nlm.nih.gov/pubmed/23139255","Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.","PR interval","13,415 African American individuals","NA","7q31.2",7,116551247,"CAV1","CAV1",null,null,857,null,null,"rs11773845-A","rs11773845",0,11773845,"intron_variant",0,0.36,{"v":4e-12,"d":"4.00E-12"},11.397940008672,null,2.29,"[1.64-2.94] unit decrease","Affymetrix, Illumina [2845108] (imputed)","N","PR interval","http://www.ebi.ac.uk/efo/EFO_0004462","GCST001735"]
[13,"rs2109514",{"v":0.51159,"d":"0.512"},{"v":0.872926,"d":"0.873"},{"v":-26.28,"d":"-26.280"},116519907,"2015-05-11",25055868,"Sano M","2014-07-23","Hum Mol Genet","www.ncbi.nlm.nih.gov/pubmed/25055868","Genome-wide association study of electrocardiographic parameters identifies a new association for PR interval and confirms previously reported associations.","Electrocardiographic traits","2,994 Japnese ancestry individuals","6,805 Korean ancestry individuals","7q31.2",7,116546187,"CAV1","CAV1",null,null,857,null,null,"rs3807989-A","rs3807989",0,3807989,"intron_variant",0,0.337,{"v":2e-06,"d":"2.00E-06"},5.69897000433601,"(PR)",2.423,"[NR] unit increase","Illumina [~ 2500000]","N","PR interval","http://www.ebi.ac.uk/efo/EFO_0004462","GCST002542"]
[13,"rs2109514",{"v":0.51159,"d":"0.512"},{"v":0.872926,"d":"0.873"},{"v":-31.34,"d":"-31.340"},116519907,"2015-04-01",25035420,"Hong KW","2014-07-17","Hum Mol Genet","www.ncbi.nlm.nih.gov/pubmed/25035420","Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.","PR interval","6,085 Korean ancestry individuals","7,295 Japanese ancestry individuals","7q31.2",7,116551247,"CAV1, CAV2","CAV1",null,null,857,null,null,"rs11773845-C","rs11773845",0,11773845,"intron_variant",0,0.34,{"v":3e-14,"d":"3.00E-14"},13.5228787452803,null,3.21,"[2.39-4.03] unit increase","Affymetrix [2100000] (imputed)","N","PR interval","http://www.ebi.ac.uk/efo/EFO_0004462","GCST002535"]
[13,"rs2109514",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},{"v":0,"d":"0.000"},116519907,"2017-07-10",28416818,"Christophersen IE","2017-04-17","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/28416818","Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.","Prevalent atrial fibrillation","8,656 European ancestry cases, 102,776 European ancestry controls.",null,"7q31.2",7,116519907,"CAV1/2","CAV2 - CAV1",858,857,null,11366,4878,"rs2109514-A","rs2109514",0,2109514,"upstream_gene_variant",1,0.51,{"v":7e-13,"d":"7.00E-13"},12.1549019599857,null,1.15,"1.11-1.19","Affymetrix, Illumina [at least 3187278] (imputed)","N","atrial fibrillation","http://www.ebi.ac.uk/efo/EFO_0000275","GCST004301"]
[13,"rs2109514",{"v":0.51159,"d":"0.512"},{"v":0.872926,"d":"0.873"},{"v":-31.34,"d":"-31.340"},116519907,"2017-07-10",28416818,"Christophersen IE","2017-04-17","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/28416818","Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.","Atrial fibrillation","15,979 European ancestry cases, 102,776 European ancestry controls.","NA","7q31.2",7,116551247,"CAV1/2","CAV1",null,null,857,null,null,"rs11773845-A","rs11773845",0,11773845,"intron_variant",0,0.6,{"v":3e-13,"d":"3.00E-13"},12.5228787452803,null,1.1,"[1.07-1.13]","Affymetrix, Illumina [11795432] (imputed)","N","atrial fibrillation","http://www.ebi.ac.uk/efo/EFO_0000275","GCST004297"]
[13,"rs2109514",{"v":0.51159,"d":"0.512"},{"v":0.872926,"d":"0.873"},-38.867,116519907,"2017-07-10",28416818,"Christophersen IE","2017-04-17","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/28416818","Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.","Atrial fibrillation","15,979 European ancestry cases, 102,776 European ancestry controls, 641 African American cases, 5,234 African American controls, 837 Japanese ancestry cases, 3,293 Japanese controls, 277 Hispanic cases, 3,081 Hispanic controls,197 Brazilian ancestry cases, 758 Brazilian ancestry controls.","8,180 Japanese ancestry cases, 28,612 Japanese ancestry controls.","7q31.2",7,116558774,"CAV1/2","CAV1",null,null,857,null,null,"rs1997572-G","rs1997572",0,1997572,"intron_variant",0,0.59,{"v":7e-15,"d":"7.00E-15"},14.1549019599857,null,1.1,"[1.08-1.17]","Affymetrix, Illumina [11795432] (imputed)","N","atrial fibrillation","http://www.ebi.ac.uk/efo/EFO_0000275","GCST004295"]
[13,"rs2109514",{"v":0.51159,"d":"0.512"},{"v":0.872926,"d":"0.873"},-38.867,116519907,"2017-07-10",28416818,"Christophersen IE","2017-04-17","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/28416818","Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.","Atrial fibrillation","15,979 European ancestry cases, 102,776 European ancestry controls, 641 African American cases, 5,234 African American controls, 837 Japanese ancestry cases, 3,293 Japanese controls, 277 Hispanic cases, 3,081 Hispanic controls,197 Brazilian ancestry cases, 758 Brazilian ancestry controls.","3,666 cases, 139,852 controls","7q31.2",7,116558774,"CAV1/2","CAV1",null,null,857,null,null,"rs1997572-G","rs1997572",0,1997572,"intron_variant",0,0.59,{"v":5e-09,"d":"5.00E-09"},8.30102999566398,null,1.16,"[1.11-1.22]","Affymetrix, Illumina [11795432] (imputed)","N","atrial fibrillation","http://www.ebi.ac.uk/efo/EFO_0000275","GCST004296"]
[14,"rs17168815",{"v":0.691106,"d":"0.691"},{"v":0.985045,"d":"0.985"},-18.013,136939874,"2013-08-20",23583979,"den Hoed M","2013-04-14","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/23583979","Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.","Heart rate","85,787 European ancestry individuals, 6,568 Indian Asian ancestry indiviudals","88,823 European ancestry individuals","7q33",7,136957887,"CHRM2","LOC349160, CHRM2",null,null,"349160, 1129",null,null,"rs2350782-C","rs2350782",0,2350782,"intron_variant",0,0.116,{"v":1e-12,"d":"1.00E-12"},12,null,0.505,"[0.35-0.66] unit increase","Affymetrix, Illumina [2516789] (imputed)","N","heart rate","http://www.ebi.ac.uk/efo/EFO_0004326","GCST001969"]
[14,"rs17168815",0.691,{"v":0.888159,"d":"0.888"},48.521,136939874,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","7q33",7,136891353,"CHRM2","CHRM2",null,null,1129,null,null,"rs73158705-G","rs73158705",0,73158705,"intron_variant",0,0.16,{"v":3e-18,"d":"3.00E-18"},17.5228787452803,null,0.3929,"[0.3-0.48] unit increase","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[14,"rs6943656",{"v":0.649009,"d":"0.649"},{"v":1,"d":"1.000"},-3.198,136954689,"2013-08-20",23583979,"den Hoed M","2013-04-14","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/23583979","Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.","Heart rate","85,787 European ancestry individuals, 6,568 Indian Asian ancestry indiviudals","88,823 European ancestry individuals","7q33",7,136957887,"CHRM2","LOC349160, CHRM2",null,null,"349160, 1129",null,null,"rs2350782-C","rs2350782",0,2350782,"intron_variant",0,0.116,{"v":1e-12,"d":"1.00E-12"},12,null,0.505,"[0.35-0.66] unit increase","Affymetrix, Illumina [2516789] (imputed)","N","heart rate","http://www.ebi.ac.uk/efo/EFO_0004326","GCST001969"]
[14,"rs6943656",{"v":0.774918,"d":"0.775"},{"v":0.897818,"d":"0.898"},63.336,136954689,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","7q33",7,136891353,"CHRM2","CHRM2",null,null,1129,null,null,"rs73158705-G","rs73158705",0,73158705,"intron_variant",0,0.16,{"v":3e-18,"d":"3.00E-18"},17.5228787452803,null,0.3929,"[0.3-0.48] unit increase","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[14,"rs6952499",{"v":0.503738,"d":"0.504"},{"v":0.768363,"d":"0.768"},42.591,136961160,"2017-07-01",28135244,"Warren HR","2017-01-30","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/28135244","Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.","Pulse pressure","140,886 European ancestry individuals","190,318 European ancestry individuals","7q33",7,136918569,"chr7mb136","LOC349160, CHRM2",null,null,"349160, 1129",null,null,"rs71784944-?","rs71784944",0,71784944,"intron_variant",0,0.212859059,{"v":3e-07,"d":"3.00E-07"},6.52287874528033,null,0.2016,"[0.12-0.28] unit decrease","Affymetrix [~ 9800000] (imputed)","N","pulse pressure measurement","http://www.ebi.ac.uk/efo/EFO_0005763","GCST004278"]
[15,"rs7072737",{"v":0.74311,"d":"0.743"},{"v":0.942688999999999,"d":"0.943"},-48.339,100796418,"2017-07-01",28135244,"Warren HR","2017-01-30","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/28135244","Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.","Systolic blood pressure","140,882 European ancestry individuals","190,318 European ancestry individuals","10q24.31",10,100844757,"PAX2","PAX2 - FAM178A",5076,55719,null,14816,65473,"rs112184198-A","rs112184198",0,112184198,"intergenic_variant",1,0.1,{"v":4e-18,"d":"4.00E-18"},17.397940008672,null,0.659,"[0.5-0.82] unit decrease","Affymetrix [~ 9800000] (imputed)","N","systolic blood pressure","http://www.ebi.ac.uk/efo/EFO_0006335","GCST004279"]
[17,"rs4963772",{"v":0.981728,"d":"0.982"},{"v":0.990822,"d":"0.991"},-12.398,24605546,"2010-09-02",20639392,"Eijgelsheim M","2010-07-16","Hum Mol Genet","www.ncbi.nlm.nih.gov/pubmed/20639392","Genome-wide association analysis identifies multiple loci related to resting heart rate.","Resting heart rate","38,991 European ancestry individuals","NA","12p12.1",12,24617944,"intergenic","LOC105369698",null,null,105369698,null,null,"rs17287293-G","rs17287293",0,17287293,"intergenic_variant",0,0.15,{"v":2e-10,"d":"2.00E-10"},9.69897000433601,null,8.6,"[6.03-11.17] ms increase","Affymetrix, Illumina [~ 2500000] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST000731"]
[17,"rs4963772",{"v":0.981728,"d":"0.982"},{"v":0.990822,"d":"0.991"},-29.859,24605546,"2010-02-04",20062060,"Pfeufer A","2010-01-10","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/20062060","Genome-wide association study of PR interval.","PR interval","28,517 European ancestry individuals","NA","12p12.1",12,24635405,"C12orf67, SOX5","LOC105369698",null,null,105369698,null,null,"rs11047543-A","rs11047543",0,11047543,"intergenic_variant",0,0.15,{"v":3e-13,"d":"3.00E-13"},12.5228787452803,null,2.09,"[1.53-2.65] ms decrease","Affymetrix, Illumina [~ 2500000] (imputed)","N","PR interval","http://www.ebi.ac.uk/efo/EFO_0004462","GCST000562"]
[17,"rs4963772",{"v":0.981728,"d":"0.982"},{"v":0.990822,"d":"0.991"},-12.398,24605546,"2013-08-20",23583979,"den Hoed M","2013-04-14","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/23583979","Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.","Heart rate","85,787 European ancestry individuals, 6,568 Indian Asian ancestry indiviudals","88,823 European ancestry individuals","12p12.1",12,24617944,"LINC00477, C12orf67","LOC105369698",null,null,105369698,null,null,"rs17287293-A","rs17287293",0,17287293,"intergenic_variant",0,0.85,{"v":3e-20,"d":"3.00E-20"},19.5228787452803,null,0.444,"[0.32-0.57] unit increase","Affymetrix, Illumina [2516789] (imputed)","N","heart rate","http://www.ebi.ac.uk/efo/EFO_0004326","GCST001969"]
[17,"rs4963772",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},{"v":0,"d":"0.000"},24605546,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","12p12.1",12,24605546,"SOX5","KNOP1P1 - LOC105369698",100129937,105369698,null,20433,9811,"rs4963772-A","rs4963772",0,4963772,"intergenic_variant",1,0.15,{"v":3e-53,"d":"3.00E-53"},52.5228787452803,null,0.7139,"[0.62-0.81] unit decrease","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[17,"rs4963772",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},{"v":0,"d":"0.000"},24605546,"2017-07-01",28135244,"Warren HR","2017-01-30","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/28135244","Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.","Pulse pressure","140,886 European ancestry individuals","190,318 European ancestry individuals","12p12.1",12,24605546,"chr12mb24","KNOP1P1 - LOC105369698",100129937,105369698,null,20433,9811,"rs4963772-A","rs4963772",0,4963772,"intergenic_variant",1,0.15156592,{"v":2e-06,"d":"2.00E-06"},5.69897000433601,null,0.2103,"[0.12-0.3] unit increase","Affymetrix [~ 9800000] (imputed)","N","pulse pressure measurement","http://www.ebi.ac.uk/efo/EFO_0005763","GCST004278"]
[18,"rs6488162",{"v":0.877232,"d":"0.877"},{"v":0.98339,"d":"0.983"},16.137,33440192,"2013-08-20",23583979,"den Hoed M","2013-04-14","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/23583979","Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.","Heart rate","85,787 European ancestry individuals, 6,568 Indian Asian ancestry indiviudals","88,823 European ancestry individuals","12p11.1",12,33424055,"SYT10","SYT10",null,null,341359,null,null,"rs7980799-A","rs7980799",0,7980799,"intron_variant",0,0.401,{"v":6e-24,"d":"6.00E-24"},23.2218487496163,null,0.377,"[0.29-0.47] unit increase","Affymetrix, Illumina [2516789] (imputed)","N","heart rate","http://www.ebi.ac.uk/efo/EFO_0004326","GCST001969"]
[18,"rs6488162",{"v":0.700885,"d":"0.701"},{"v":0.887184,"d":"0.887"},-89.278,33440192,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","12p11.1",12,33529470,"SYT10","ST13P9 - RNU6-400P",390301,106481304,null,74015,46625,"rs1994135-C","rs1994135",0,1994135,"intergenic_variant",1,0.47,{"v":7e-34,"d":"7.00E-34"},33.1549019599857,null,0.4,"[0.34-0.46] unit increase","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[18,"rs6488162",{"v":0.569456,"d":"0.569"},{"v":0.865951,"d":"0.866"},{"v":36.77,"d":"36.770"},33440192,"2017-03-17",27089181,"Okbay A","2016-04-18","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27089181","Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.","Life satisfaction","166,205 European ancestry individuals","NA","12p11.1",12,33403422,"NR","SYT10",null,null,341359,null,null,"rs12424970-T","rs12424970",0,12424970,"intron_variant",0,0.506,{"v":7e-06,"d":"7.00E-06"},5.15490195998574,null,0.0159,"[0.009-0.0228] unit decrease","Affymetrix, Illumina, Perlegen [at least 5170349] (imputed)","N","wellbeing measurement","http://www.ebi.ac.uk/efo/EFO_0007869","GCST003767"]
[20,"rs17180489",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},{"v":0,"d":"0.000"},72418763,"2017-03-27",27798624,"Eppinga RN","2016-10-31","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/27798624","Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.","Resting heart rate","127,919 European ancestry individuals, 2,478 Asian ancestry individuals, 1,734 Black individuals, 684 Mixed ancestry individuals, 1,436 individuals","130,795 European ancestry individuals","14q24.2",14,72418763,"RGS6","LOC105370559, RGS6",null,null,"105370559, 9628",null,null,"rs17180489-C","rs17180489",0,17180489,"intron_variant",0,0.14,{"v":9e-19,"d":"9.00E-19"},18.0457574905606,null,0.4896,"[0.38-0.6] unit decrease","Affymetrix [19941912] (imputed)","N","resting heart rate","http://www.ebi.ac.uk/efo/EFO_0004351","GCST003818"]
[21,"rs12906962",{"v":1,"d":"1.000"},{"v":1,"d":"1.000"},{"v":0,"d":"0.000"},94768842,"2017-07-01",28135244,"Warren HR","2017-01-30","Nat Genet","www.ncbi.nlm.nih.gov/pubmed/28135244","Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.","Diastolic blood pressure","140,886 European ancestry individuals","190,318 European ancestry individuals","15q26.2",15,94768842,"chr15mb95","LOC105370988",null,null,105370988,null,null,"rs12906962-T","rs12906962",0,12906962,"intergenic_variant",0,0.68,{"v":6e-14,"d":"6.00E-14"},13.2218487496163,null,0.221,"[0.16-0.28] unit decrease","Affymetrix [~ 9800000] (imputed)","N","diastolic blood pressure","http://www.ebi.ac.uk/efo/EFO_0006336","GCST004280"]