{"text_format":"3","workbook":"xlsx","n_sheets":8,"sheets":["Figure 1 c RT-PCR","Figure 1 e qPCR","Figure 1 f RNF170 WB","Figure 2 a+b","Figure 2 c+d","Figure 3 a+b","Figure 3 c+d","Figure 3e"],"not_rendered":{"images":38},"read":"whole","date_system":"1900"}

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["Family A RT-PCR:"]

{"sheet":"Figure 1 e qPCR","index":1,"n_rows":63,"n_cols":15,"rows_kept":63,"merged":[[5,5,5,6],[5,7,5,8],[5,9,5,12],[14,5,14,6],[14,7,14,8],[14,9,14,12],[26,5,26,6],[26,7,26,8],[26,9,26,12],[35,5,35,6],[35,7,35,8],[35,9,35,12],[47,5,47,6],[47,7,47,8],[47,9,47,12],[56,5,56,6],[56,7,56,8],[56,9,56,12]]}
["Family A qPCR:"]
[]
["Relative Quantification: all to mean RNF170_2 PaxGene_Fibroblasten_Lauf 1_11_10_17"]
[]
["RNF170_2 Pax Gene all to mean"]
[{"$nulls":5},"Target",null,"Reference",null,"Ratio"]
["Chart","Pairing","Sample Name","Targets","References","Mean Cp","CP Error","Mean Cp","Cp Error","Target/Ref","Target/Ref Error","Normalized","Normalized Error","Target/Ref SP/CO","Status"]
["True",null,"Cali","RNF170_2","RNF10;RNF111;RPLP0",21.9260530004921,0.135902073708273,15.9449616841572,0.439599511921826,0.2561,{"v":0.043,"d":"4.30E-02"},1,null,null,"E - Extrapolated Standard Curve"]
["True","A11/A2","PG-SP-171","RNF170_2","RNF10;RNF111;RPLP0",23.1497636800851,1.212793521707,16.4310182262773,1.5686128070521,0.135,0.1205,0.5272,0.4899,0.4821428571428572]
["True","D11/D2","PG-CO-4","RNF170_2","RNF10;RNF111;RPLP0",23.1759643327371,1.11964825823292,16.7592470244361,1.48349691436701,0.1641,0.1784,0.6409,0.7181]
["True","G11/G2","PG-CO-5","RNF170_2","RNF10;RNF111;RPLP0",21.6429148429082,0.435163740713863,16.3553156992512,1.25314315560105,0.3653,0.116,1.427,0.5054]
["True","J11/J2","PG-CO-6","RNF170_2","RNF10;RNF111;RPLP0",22.4284125736301,0.376408333312807,16.8007288034339,1.54592883446122,0.3106,0.0964,1.213,0.4347]
[]
["RNF170_2 Fibros  all to mean"]
[{"$nulls":5},"Target",null,"Reference",null,"Ratio"]
["Chart","Pairing","Sample Name","Targets","References","Mean Cp","CP Error","Mean Cp","Cp Error","Target/Ref","Target/Ref Error","Normalized","Normalized Error","Target/Ref SP/CO","Status"]
["True",null,"Cali","RNF170_2","RNF10;RNF111;RPLP0",21.9260530004921,0.135902073708273,15.9449616841572,0.439599511921826,0.2561,{"v":0.043,"d":"4.30E-02"},1,null,null,"E - Extrapolated Standard Curve"]
["True","M11/M2","F-SP_171","RNF170_2","RNF10;RNF111;RPLP0",20.8354430201235,0.612489846745519,15.9114253073387,2.82213516287238,0.516,0.1797,2.015,0.7923,0.35805981541877735]
["True","A12/A3","F-CO-9","RNF170_2","RNF10;RNF111;RPLP0",19.0810235289923,0.315668711846058,16.9461971714987,2.19578270238084,2.637,0.5495,10.3,2.79]
["True","D12/D3","F-CO-23","RNF170_2","RNF10;RNF111;RPLP0",20.197363251997,0.108563737947413,16.412248253605,2.5869641542708,1.016,0.1277,3.969,0.8301]
["True","G12/G3","F-CO-61","RNF170_2","RNF10;RNF111;RPLP0",19.4721735662105,0.524465392199699,15.1552830933736,3.05288720061763,0.6703,0.1873,2.617,0.8664]
[]
[]
["Relative Quantification: all to mean RNF170_2 PaxGene_Fibroblasten_Lauf 2_24_10_17"]
[]
["RNF170_2 Pax Gene all to mean"]
[{"$nulls":5},"Target",null,"Reference",null,"Ratio"]
["Chart","Pairing","Sample Name","Targets","References","Mean Cp","CP Error","Mean Cp","Cp Error","Target/Ref","Target/Ref Error","Normalized","Normalized Error","Target/Ref SP/CO","Status"]
["True",null,"Cali","RNF170_2","RNF10;RNF111;RPLP0",21.7574241425184,0.318291284000915,16.2993966448402,0.679304507569499,0.3583,{"v":0.0671,"d":"6.71E-02"},1]
["True","A11/A2","PG-SP-171","RNF170_2","RNF10;RNF111;RPLP0",23.0868030701346,1.03483301960513,16.6274468022133,1.46984652078745,0.1943,0.1049,0.5423,0.3211,0.715126978284873]
["True","D11/D2","PG-CO-4","RNF170_2","RNF10;RNF111;RPLP0",22.8553199536141,1.00087023424297,16.860840319314,1.56692332782302,0.2531,0.1515,0.7065,0.4579]
["True","G11/G2","PG-CO-5","RNF170_2","RNF10;RNF111;RPLP0",21.5200947308258,0.439363491863645,16.0858147430804,1.08965039951936,0.3622,0.1038,1.011,0.356]
["True","J11/J2","PG-CO-6","RNF170_2","RNF10;RNF111;RPLP0",23.2698903190496,0.914342712731985,16.8351316959374,1.59685139294297,0.1998,0.0884,0.5577,0.2781]
[]
["RNF170_2 Fibros  all to mean"]
[{"$nulls":5},"Target",null,"Reference",null,"Ratio"]
["Chart","Pairing","Sample Name","Targets","References","Mean Cp","CP Error","Mean Cp","Cp Error","Target/Ref","Target/Ref Error","Normalized","Normalized Error","Target/Ref SP/CO","Status"]
["True",null,"Cali","RNF170_2","RNF10;RNF111;RPLP0",21.7574241425184,0.318291284000915,16.2993966448402,0.679304507569499,0.3583,{"v":0.0671,"d":"6.71E-02"},1]
["True","M11/M2","F-SP_171","RNF170_2","RNF10;RNF111;RPLP0",20.663364515296,0.374238505629789,16.0182119536932,2.82839752551489,0.5669,0.1203,1.582,0.4596,0.3841479942175641]
["True","A12/A3","F-CO-9","RNF170_2","RNF10;RNF111;RPLP0",18.996226158785,0.402985785067373,16.8743943277981,2.16023067944106,2.436,0.4881,6.801,1.915]
["True","D12/D3","F-CO-23","RNF170_2","RNF10;RNF111;RPLP0",19.8973540691716,0.110250171226854,16.3538856699035,2.59608317400912,1.07,0.1193,2.985,0.6619]
["True","G12/G3","F-CO-61","RNF170_2","RNF10;RNF111;RPLP0",19.243202587934,0.278336353805241,15.4120356910209,2.82817778504906,0.9212,0.1438,2.571,0.6408]
[]
[]
["Relative Quantification: all to mean RNF170_2 PaxGene_Fibroblasten_Lauf 3_26_10_17"]
[]
["RNF170_2 Pax Gene all to mean"]
[{"$nulls":5},"Target",null,"Reference",null,"Ratio"]
["Chart","Pairing","Sample Name","Targets","References","Mean Cp","CP Error","Mean Cp","Cp Error","Target/Ref","Target/Ref Error","Normalized","Normalized Error","Target/Ref SP/CO","Status"]
["True",null,"Cali","RNF170_2","RNF10;RNF111;RPLP0",21.9991398450503,0.198833633118618,16.240814156706,0.73403588439495,0.2499,{"v":0.0483,"d":"4.83E-02"},1]
["True","B11/A2","PG-SP-171","RNF170_2","RNF10;RNF111;RPLP0",23.6532889172975,0.254009776387829,16.4699982524883,1.47648239843069,0.107,0.0246,0.4281,0.1269,0.448073701842546]
["True","D11/D2","PG-CO-4","RNF170_2","RNF10;RNF111;RPLP0",22.8831852738723,1.13967107703776,16.8409864680594,1.54905813406858,0.2137,0.1279,0.8555,0.5515]
["True","G11/G2","PG-CO-5","RNF170_2","RNF10;RNF111;RPLP0",21.7234347624194,0.220664337934901,16.3303421634051,1.1023729892978,0.3161,0.0748,1.265,0.3824]
["True","J11/J2","PG-CO-6","RNF170_2","RNF10;RNF111;RPLP0",23.1106583469173,0.490844363313967,16.7831448936943,1.48298910842457,0.1866,0.0593,0.7468,0.2791]
[]
["RNF170_2 Fibros  all to mean"]
[{"$nulls":5},"Target",null,"Reference",null,"Ratio"]
["Chart","Pairing","Sample Name","Targets","References","Mean Cp","CP Error","Mean Cp","Cp Error","Target/Ref","Target/Ref Error","Normalized","Normalized Error","Target/Ref SP/CO","Status"]
["True",null,"Cali","RNF170_2","RNF10;RNF111;RPLP0",21.9991398450503,0.198833633118618,16.240814156706,0.73403588439495,0.2499,{"v":0.0483,"d":"4.83E-02"},1]
["True","M11/M2","F-SP_171","RNF170_2","RNF10;RNF111;RPLP0",20.699306794566,0.244548769687287,15.9341693728107,2.80611867166355,0.4731,0.1116,1.893,0.5729,0.341892901018958]
["True","A12/A3","F-CO-9","RNF170_2","RNF10;RNF111;RPLP0",18.9015426144734,0.206669421214154,16.837950921459,2.18837270053673,2.54,0.4257,10.17,2.538]
["True","D12/D3","F-CO-23","RNF170_2","RNF10;RNF111;RPLP0",19.8878948544064,0.323942571644479,16.2710358933958,2.58147949182051,0.9647,0.2428,3.861,1.224]
["True","G12/G3","F-CO-61","RNF170_2","RNF10;RNF111;RPLP0",19.3000263127778,0.288207959489056,14.9330034755223,3.24793207083847,0.6466,0.1152,2.588,0.6704,null,"C, N, E - Target/Reference ratio uncertain, Normalized ratio uncertain, Extrapolated Standard Curve"]

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["Family A RNF170 WB:"]

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[null,null,"WB 1"]
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["WB 2:",null,null,7,"Co5",{"v":2549966.5,"d":"2,549,966.50"},{"v":3319724,"d":"3,319,724.00"},0.768126055,0.536082363]
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["Quantification Data: "]
["WB 2: ",{"$nulls":13},"WB 3: "]
[null,"Cell lines","IP3R-3","Vinculin","Normalized to Vinculin",{"$nulls":10},"Cell lines","IP3R-3","Vinculin","Normalized to Vinculin"]
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[6,"A.4",{"v":9202.146,"d":"9202.15"},{"v":16381.167,"d":"16381.17"},{"v":0.561751552865556,"d":"0.56 "}]
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[8,"Co2",4991.64,{"v":15009.459,"d":"15009.46"},{"v":0.3325662837014978,"d":"0.33 "}]
[9,"Co3",{"v":3656.569,"d":"3656.57"},13741.56,{"v":0.2660956252419667,"d":"0.27 "}]
[]
[]
["WB 4:"]
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["WB 4: "]
[null,"Cell lines","IP3R-3","Vinculin","Normalized to Vinculin"]
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[null,"C.4",{"v":2078052.052632,"d":"2,078,052.05"},{"v":3353410.71,"d":"3,353,410.71"},{"$f":"C111/D111","v":0.6196831322913023}]
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[]
[null,"A.4",{"v":3082424.052632,"d":"3,082,424.05"},{"v":4686942.71,"d":"4,686,942.71"},0.6576619863638146]
[null,"C.4",{"v":2287692.052632,"d":"2,287,692.05"},{"v":3883922.71,"d":"3,883,922.71"},0.5890158541883033]
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[null,"Co2",{"v":1311452.052632,"d":"1,311,452.05"},{"v":4059982.71,"d":"4,059,982.71"},0.3230191225696131]
[]
["WB5",{"$nulls":7},"WB6",{"$nulls":6},"WB7"]
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[null,"C.4 basal",{"v":43070617.479592,"d":"43,070,617.48"},{"v":107251216.716023,"d":"107,251,216.72"},{"$f":"C147/D147","v":0.40158628310607675},{"$nulls":4},"C.4 basal",{"v":1567263.157895,"d":"1,567,263.16"},{"v":4910244.756098,"d":"4,910,244.76"},{"$f":"K147/L147","v":0.31918228840805263},{"$nulls":3},"C.4 basal",{"v":46079822.666667,"d":"46,079,822.67"},{"v":91765887.177719,"d":"91,765,887.18"},{"$f":"R147/S147","v":0.5021454495113877}]
[null,"C.4 starved",{"v":45250809.479592,"d":"45,250,809.48"},{"v":87943089.716023,"d":"87,943,089.72"},{"$f":"C148/D148","v":0.5145465053105522},{"$nulls":4},"C.4 starved",{"v":1331332.631579,"d":"1,331,332.63"},{"v":3534996,"d":"3,534,996.00"},{"$f":"K148/L148","v":0.3766150319771225},{"$nulls":3},"C.4 starved",{"v":43170294.666667,"d":"43,170,294.67"},{"v":51910132.177719,"d":"51,910,132.18"},{"$f":"R148/S148","v":0.831635229108445}]
[null,"A.4 basal",{"v":54325521.479592,"d":"54,325,521.48"},{"v":85794802.716023,"d":"85,794,802.72"},0.6332029419008873,{"$nulls":4},"A.4 basal",{"v":1973938.736842,"d":"1,973,938.74"},{"v":2545724.869565,"d":"2,545,724.87"},0.775393586495188,{"$nulls":3},"A.4 basal",{"v":43134758.666667,"d":"43,134,758.67"},{"v":47224767.177719,"d":"47,224,767.18"},0.913392722601252]
[null,"A.4 starved",{"v":58311755.479592,"d":"58,311,755.48"},{"v":96160478.716023,"d":"96,160,478.72"},0.6064004283068908,{"$nulls":4},"A.4 starved",{"v":1876738.947368,"d":"1,876,738.95"},{"v":2573550.909091,"d":"2,573,550.91"},0.7292410423040281,{"$nulls":3},"A.4 starved",{"v":47324267.666667,"d":"47,324,267.67"},{"v":39430657.205128,"d":"39,430,657.21"},1.2001896752690298]
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[null,"Co1 starved",{"v":13995058.479592,"d":"13,995,058.48"},{"v":70250013.716023,"d":"70,250,013.72"},0.19921787540377278,{"$nulls":4},"Co1 starved",{"v":591902.736842,"d":"591,902.74"},{"v":2925172.363636,"d":"2,925,172.36"},0.20234798612217939,{"$nulls":3},"Co1 starved",{"v":13273263.666667,"d":"13,273,263.67"},{"v":36423512.205128,"d":"36,423,512.21"},0.36441471080315757]
[null,"Co2 basal",{"v":9777873.479592,"d":"9,777,873.48"},{"v":88233601.716023,"d":"88,233,601.72"},0.1108180249862379,{"$nulls":4},"Co2 basal",{"v":541289.894737,"d":"541,289.89"},{"v":3018492.363636,"d":"3,018,492.36"},0.1793245864253159,{"$nulls":3},"Co2 basal",{"v":10389546.666667,"d":"10,389,546.67"},{"v":36776891.205128,"d":"36,776,891.21"},0.2825020366381139]
[null,"Co2 starved",{"v":11288267.479592,"d":"11,288,267.48"},{"v":93148362.716023,"d":"93,148,362.72"},0.12118589259594402,{"$nulls":4},"Co2 starved",{"v":686440.210526,"d":"686,440.21"},{"v":3696430.782609,"d":"3,696,430.78"},0.18570352074643734,{"$nulls":3},"Co2 starved",{"v":10894527.666667,"d":"10,894,527.67"},{"v":35271269.205128,"d":"35,271,269.21"},0.3088782431759805]

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[1,"A.4 0 min",14334.924,15995.309,{"v":0.8961955033191294,"d":"0.90"},{"$f":"E22/E22","v":1},null,1,"A.4 0 min",10941.024,22434.572,{"v":0.48768588052404116,"d":"0.49"},{"$f":"L22/L22","v":1},null,1,"A.4 0 min",14062.974,22720.037,{"$f":"Q22/R22","v":{"v":0.6189679180540066,"d":"0.62"}},{"$f":"S22/S22","v":1}]
[2,"A.4 30 min",{"v":15916.53,"d":"15916.530"},15117.602,{"v":1.0528475349463493,"d":"1.05"},{"$f":"E23/E22","v":1.1747967168402953},null,2,"A.4 30 min",10627.246,20840.915,{"v":0.5099222370994747,"d":"0.51"},{"$f":"L23/L22","v":1.04559565380802},null,2,"A.4 30 min",10561.731,20837.329,{"$f":"Q23/R23","v":{"v":0.5068658751800674,"d":"0.51"}},{"$f":"S23/S22","v":0.8188887669228795}]
[3,"A.4 60 min",7220.146,16130.037,{"v":0.44762116788696765,"d":"0.45"},{"$f":"E24/E22","v":0.4994682145013761},null,3,"A.4 60 min",9470.075,20805.158,{"v":0.4551791916216162,"d":"0.46"},{"$f":"L24/L22","v":0.93334502760774},null,3,"A.4 60 min",{"v":19312.51,"d":"19312.510"},19723.451,{"$f":"Q24/R24","v":{"v":0.9791648530472683,"d":"0.98"}},{"$f":"S24/S22","v":1.5819315096745183}]
[4,"Co1 0 min",5112.246,18057.794,{"v":0.28310468044989323,"d":"0.28"},{"$f":"E25/E25","v":1},null,4,"Co1 0 min",{"v":7533.64,"d":"7533.640"},17304.279,{"v":0.4353628371340985,"d":"0.44"},{"$f":"L25/L25","v":1},null,4,"Co1 0 min",3137.347,23214.451,{"$f":"Q25/R25","v":{"v":0.13514629314300822,"d":"0.14"}},{"$f":"S25/S25","v":1}]
[5,"Co1 30 min",730.113,18000.551,{"v":0.040560591728553204,"d":"0.04"},{"$f":"E26/E25","v":0.1432706505031874},null,5,"Co1 30 min",2527.912,{"v":15809.38,"d":"15809.380"},{"v":0.15989950270029565,"d":"0.16"},{"$f":"L26/L25","v":0.36727871343562596},null,5,"Co1 30 min",1025.062,23454.108,{"$f":"Q26/R26","v":{"v":0.04370500894768626,"d":"0.04"}},{"$f":"S26/S25","v":0.323390364110385}]
[6,"Co1 60 min",663.113,17133.673,{"v":0.038702326115363596,"d":"0.04"},{"$f":"E27/E25","v":0.1367067688667674},null,6,"Co1 60 min",1843.669,16204.137,{"v":0.11377767294858097,"d":"0.11"},{"$f":"L27/L25","v":0.26133988306754735},null,6,"Co1 60 min",{"v":652.92,"d":"652.920"},17325.551,{"$f":"Q27/R27","v":{"v":0.037685381550058634,"d":"0.04"}},{"$f":"S27/S25","v":0.2788487991319227}]
[7,"Co3 0 min",3825.882,13639.066,{"v":0.2805090905784898,"d":"0.28"},{"$f":"E28/E28","v":1},null,7,"Co3 0 min",7803.296,19676.966,{"v":0.3965700809769148,"d":"0.40"},{"$f":"L28/L28","v":1},null,7,"Co3 0 min",8758.903,17558.087,{"$f":"Q28/R28","v":{"v":0.498852921733444,"d":"0.50"}},{"$f":"S28/S28","v":1}]
[8,"Co3 30 min",1459.255,{"v":15135.48,"d":"15135.480"},{"v":0.09641286566398952,"d":"0.10"},{"$f":"E29/E28","v":0.34370674214214836},null,8,"Co3 30 min",6511.004,{"v":20170.38,"d":"20170.380"},{"v":0.3228002645463298,"d":"0.32"},{"$f":"L29/L28","v":0.81398037832592},null,8,"Co3 30 min",7008.125,18012.158,{"v":0.38907747755710337,"d":"0.39"},{"$f":"S29/S28","v":0.7799442693552113}]
[9,"Co3 60 min",1580.841,18473.551,{"v":0.08557320679711226,"d":"0.09"},{"$f":"E30/E28","v":0.3050639343653209},null,9,"Co3 60 min",5579.418,13844.238,{"v":0.40301373033315374,"d":"0.40"},{"$f":"L30/L28","v":1.016248450564817},null,9,"Co3 60 min",4243.518,14710.794,{"v":0.2884628797058813,"d":"0.29"},{"$f":"S30/S28","v":0.5782523608431784}]
[]
[]
["WB4",{"$nulls":6},"WB5",{"$nulls":6},"WB6",{"$nulls":6},"WB7"]
{"$rows_empty":24}
["WB4","Cell lines","IP3R-3","Vinculin","Normalized to Vinculin","each sample normalized to t=0",null,"WB5","Cell lines","IP3R-3","Vinculin","Normalized to Vinculin","each sample normalized to t=0",null,"WB6","Cell lines","IP3R-3","Vinculin","Normalized to Vinculin","each sample normalized to t=0",null,"WB7","Cell lines","IP3R-3","Vinculin","Normalized to Vinculin","each sample normalized to t=0"]
[1,"C.4 0 min",{"v":10636952,"d":"10,636,952.00"},{"v":5954692,"d":"5,954,692.00"},{"$f":"C59/D59","v":1.786314388720693},{"$f":"E59/$E$59","v":1},null,1,"C.4 0 min",{"v":3892608,"d":"3,892,608.00"},{"v":11744419,"d":"11,744,419.00"},{"$f":"J59/K59","v":0.3314432157095213},{"$f":"L59/$L$59","v":1},null,1,"C.4 0 min",{"v":2259362.842105,"d":"2,259,362.84"},{"v":1700407.578947,"d":"1,700,407.58"},{"$f":"Q59/R59","v":1.3287184026221175},{"$f":"S59/$S$59","v":1},null,1,"C.4 0 min",{"v":1076360.848485,"d":"1,076,360.85"},{"v":7075811,"d":"7,075,811.00"},{"$f":"X59/Y59","v":0.15211837180006646},{"$f":"Z59/$Z$59","v":1}]
[2,"C.4 30 min",{"v":7333312,"d":"7,333,312.00"},{"v":4865216,"d":"4,865,216.00"},{"$f":"C60/D60","v":1.5072942290743103},{"$f":"E60/$E$59","v":0.843801202404125},null,2,"C.4 30 min",{"v":5110322.5,"d":"5,110,322.50"},{"v":10195332,"d":"10,195,332.00"},{"$f":"J60/K60","v":0.501241401457059},{"$f":"L60/$L$59","v":1.5122994760476551},null,2,"C.4 30 min",{"v":2232804.473684,"d":"2,232,804.47"},{"v":1546603.578947,"d":"1,546,603.58"},{"$f":"Q60/R60","v":1.4436824691717043},{"$f":"S60/$S$59","v":1.086522521493429},null,2,"C.4 30 min",{"v":1541057.939394,"d":"1,541,057.94"},{"v":6864704,"d":"6,864,704.00"},{"$f":"X60/Y60","v":0.22449007843513719},{"$f":"Z60/$Z$59","v":1.4757591458459136}]
[3,"C.4 60 min",{"v":6441107,"d":"6,441,107.00"},{"v":4083932,"d":"4,083,932.00"},1.577182724883764,0.8829256119989589,null,3,"C.4 60 min",{"v":4719167.5,"d":"4,719,167.50"},{"v":10085814.5,"d":"10,085,814.50"},0.46790147687130274,1.4117093206136833,null,3,"C.4 60 min",{"v":2727648.842105,"d":"2,727,648.84"},{"v":1256923.578947,"d":"1,256,923.58"},2.170099191225384,1.6332273165953524,null,3,"C.4 60 min",{"v":2103931.272727,"d":"2,103,931.27"},{"v":6333576,"d":"6,333,576.00"},0.3321869466359921,2.1837398251448215]
[4,"Co1 0 min",{"v":3805084,"d":"3,805,084.00"},{"v":4361864,"d":"4,361,864.00"},0.8723527372701212,{"$f":"E62/$E$62","v":1},null,4,"Co1 0 min",{"v":1843509.5,"d":"1,843,509.50"},{"v":10999150,"d":"10,999,150.00"},0.1676047240014001,{"$f":"L62/$L$62","v":1},null,4,"Co1 0 min",{"v":958740.842105,"d":"958,740.84"},{"v":1339787.578947,"d":"1,339,787.58"},0.715591678240903,{"$f":"S62/$S$62","v":1},null,4,"Co1 0 min",{"v":887214.787879,"d":"887,214.79"},{"v":6515308,"d":"6,515,308.00"},0.1361738827817503,{"$f":"Z62/$Z$62","v":1}]
[5,"Co1 30 min",{"v":2281696,"d":"2,281,696.00"},{"v":5176876,"d":"5,176,876.00"},0.4407476632625545,{"$f":"E63/$E$62","v":0.5052401906157812},null,5,"Co1 30 min",{"v":2242928.5,"d":"2,242,928.50"},{"v":10277675,"d":"10,277,675.00"},0.2182330634117152,{"$f":"L63/$L$62","v":1.3020698832444135},null,5,"Co1 30 min",{"v":675334.368421,"d":"675,334.37"},{"v":1566167.578947,"d":"1,566,167.58"},0.4312018570037413,{"$f":"S63/$S$62","v":0.6025808713479446},null,5,"Co1 30 min",{"v":1078206.787879,"d":"1,078,206.79"},{"v":6658332,"d":"6,658,332.00"},0.16193346740279696,{"$f":"Z63/$Z$62","v":1.189166851196659}]
[6,"Co1 60 min",{"v":1825676,"d":"1,825,676.00"},{"v":4425904,"d":"4,425,904.00"},0.4124978761401061,0.47285674534701144,null,6,"Co1 60 min",{"v":1643265,"d":"1,643,265.00"},{"v":10482948,"d":"10,482,948.00"},0.15675600031594167,0.9352719695098343,null,6,"Co1 60 min",{"v":635876.736842,"d":"635,876.74"},{"v":1660347.578947,"d":"1,660,347.58"},0.3829780853749165,0.5351908036666512,null,6,"Co1 60 min",{"v":528851.757576,"d":"528,851.76"},{"v":6423935,"d":"6,423,935.00"},0.08232520372264039,0.6045594209470057]
[7,"Co2 0 min",{"v":1650528,"d":"1,650,528.00"},{"v":3018554.6,"d":"3,018,554.60"},0.546794151081448,{"$f":"E65/$E$65","v":1},null,7,"Co2 0 min",{"v":1358575,"d":"1,358,575.00"},{"v":7037995,"d":"7,037,995.00"},0.19303437981982086,{"$f":"L65/$L$65","v":1},null,7,"Co2 0 min",{"v":401617.368421,"d":"401,617.37"},{"v":1372851.578947,"d":"1,372,851.58"},0.29254245293511427,{"$f":"S65/$S$65","v":1},null,7,"Co2 0 min",{"v":207655.151515,"d":"207,655.15"},{"v":6293096,"d":"6,293,096.00"},0.0329972960074024,{"$f":"Z65/$Z$65","v":1}]
[8,"Co2 30 min",{"v":1806520,"d":"1,806,520.00"},{"v":4211357.2,"d":"4,211,357.20"},0.42896385041857765,{"$f":"E66/$E$65","v":0.7845070207319776},null,8,"Co2 30 min",{"v":840738,"d":"840,738.00"},{"v":9104902,"d":"9,104,902.00"},0.09233904988763196,{"$f":"L66/$L$65","v":0.47835546172563476},null,8,"Co2 30 min",{"v":326806.473684,"d":"326,806.47"},{"v":1239555.578947,"d":"1,239,555.58"},0.2636481003632136,{"$f":"S66/$S$65","v":0.901230223914512},null,8,"Co2 30 min",{"v":117110.545455,"d":"117,110.55"},{"v":6329616,"d":"6,329,616.00"},0.018501998455356532,{"$f":"Z66/$Z$65","v":0.5607125641811957}]
[9,"Co2 60 min",{"v":1453528,"d":"1,453,528.00"},{"v":3349416,"d":"3,349,416.00"},0.43396460756143757,0.7936526144311228,null,9,"Co2 60 min",{"v":453313.5,"d":"453,313.50"},{"v":10240625,"d":"10,240,625.00"},0.044266194690265485,0.2293176724870655,null,9,"Co2 60 min",{"v":319878.789474,"d":"319,878.79"},{"v":1534111.578947,"d":"1,534,111.58"},0.20851077187851083,0.7127538919103764,null,9,"Co2 60 min",{"v":70198.424242,"d":"70,198.42"},{"v":6900574,"d":"6,900,574.00"},0.010172838410543818,0.3082930919024913]

{"sheet":"Figure 3 a+b","index":5,"n_rows":67,"n_cols":11,"rows_kept":67}
["WB 1:",{"$nulls":5},"WB 2:"]
{"$rows_empty":18}
["Quantification Data: "]
["WB 1: ",{"$nulls":5},"WB 2: "]
[null,"Cell lines","IP3R-1 ","Vinculin ","normalized to Vinculin",null,null,"Cell lines","IP3R-1 ","Vinculin ","normalized to Vinculin"]
[1,"KO basal 1",{"v":2470852.444444,"d":"2,470,852.44"},{"v":387534.769231,"d":"387,534.77"},{"$f":"C23/D23","v":6.375821321392675},null,1,"KO basal 1",{"v":3219332.263158,"d":"3,219,332.26"},{"v":342475.133903,"d":"342,475.13"},{"$f":"I23/J23","v":9.400192727772811}]
[2,"KO basal 2",{"v":2855107.111111,"d":"2,855,107.11"},{"v":428006.769231,"d":"428,006.77"},6.670705503655404,null,2,"KO basal 2",{"v":2685634.631579,"d":"2,685,634.63"},{"v":369187.133903,"d":"369,187.13"},7.274453481590239]
[3,"KO basal 3",{"v":2299189.777778,"d":"2,299,189.78"},{"v":412342.769231,"d":"412,342.77"},5.575918748535064,null,3,"KO basal 3",{"v":2691447.263158,"d":"2,691,447.26"},{"v":368359.133903,"d":"368,359.13"},7.306584839204066]
[4,"WT basal 1",{"v":1809277.777778,"d":"1,809,277.78"},{"v":495798.769231,"d":"495,798.77"},3.649217969185863,null,4,"WT basal 1",{"v":3541660.947368,"d":"3,541,660.95"},{"v":659639.133903,"d":"659,639.13"},5.369088590018071]
[5,"WT basal 2",{"v":1784468.444444,"d":"1,784,468.44"},{"v":463022.769231,"d":"463,022.77"},3.853953980292785,null,5,"WT basal 2",{"v":2572318.052632,"d":"2,572,318.05"},{"v":694743.133903,"d":"694,743.13"},3.702545483509804]
[6,"WT basal 3",{"v":1875339.555556,"d":"1,875,339.56"},{"v":430474.769231,"d":"430,474.77"},4.3564447665680985,null,6,"WT basal 3",{"v":2297763.894737,"d":"2,297,763.89"},{"v":693163.133903,"d":"693,163.13"},3.314896281051417]
[7,"WT rescue basal 1",{"v":1522664.444444,"d":"1,522,664.44"},{"v":271206.769231,"d":"271,206.77"},5.614404274500512,null,7,"WT rescue basal 1",{"v":2669051.210526,"d":"2,669,051.21"},{"v":399939.133903,"d":"399,939.13"},6.67364352290002]
[8,"WT rescue basal 2",{"v":1245700.888889,"d":"1,245,700.89"},{"v":216798.769231,"d":"216,798.77"},5.745885427798257,null,8,"WT rescue basal 2",{"v":1348072.894737,"d":"1,348,072.89"},{"v":289763.133903,"d":"289,763.13"},4.652327149347701]
[9,"WT rescue basal 3",{"v":769854.222222,"d":"769,854.22"},{"v":217514.769231,"d":"217,514.77"},3.5393193066555275,null,9,"WT rescue basal 3",{"v":1083512.263158,"d":"1,083,512.26"},{"v":217587.133903,"d":"217,587.13"},4.979670643766226]
[]
[]
["WB 3:"]
{"$rows_empty":22}
["Quantification Data: "]
["WB 3: "]
[null,"Cell lines","IP3R-1 ","Vinculin ","normalized to Vinculin"]
[1,"SH-SY5Y RNF170 KO basal 1",{"v":2186250.162162,"d":"2,186,250.16"},{"v":2424830,"d":"2,424,830.00"},{"$f":"C60/D60","v":0.9016096642494524}]
[2,"SH-SY5Y RNF170 KO basal 2",{"v":2712022.27027,"d":"2,712,022.27"},{"v":1745022,"d":"1,745,022.00"},1.5541478962844022]
[3,"SH-SY5Y RNF170 KO basal 3",{"v":2066553.621622,"d":"2,066,553.62"},{"v":1753146,"d":"1,753,146.00"},1.178768694462412]
[4,"SH-SY5Y RNF170 KO basal 4",{"v":1825061.513514,"d":"1,825,061.51"},{"v":2191482,"d":"2,191,482.00"},0.8327978571186074]
[5,"SH-SY5Y alt basal 1",{"v":1374376.756757,"d":"1,374,376.76"},{"v":2236830,"d":"2,236,830.00"},0.614430581115686]
[6,"SH-SY5Y alt basal 2",{"v":1194522.27027,"d":"1,194,522.27"},{"v":2046810,"d":"2,046,810.00"},0.5836019319184487]
[7,"SH-SY5Y alt basal 3",{"v":1097642.162162,"d":"1,097,642.16"},{"v":2406130,"d":"2,406,130.00"},0.4561857265243358]
[8,"SH-SY5Y alt basal 4",{"v":764386.378378,"d":"764,386.38"},{"v":2109006,"d":"2,109,006.00"},0.36243916725604386]

{"sheet":"Figure 3 c+d","index":6,"n_rows":364,"n_cols":16,"rows_kept":364}
[]
["WB 1:",{"$nulls":4},"WB 2:",null,null,"WB 3:",null,null,"WB 4:"]
{"$rows_empty":18}
[null,"SH-SY5Y","IP3R1","Vinculin","Ratio IP3/Vinculin","normalized to 1","normalized to 100%"]
[null,"WB1"]
[1,"KO 0h",37551960.33,97620818.92,0.384671638134625,1,100]
[2,"KO 2h",51271143.27,87685995.92,0.5847130175356284,1.520031527073473,152.0031527073473]
[3,"KO 4h",56523189,80716041.92,0.7002720606149365,1.0849436987495615,108.49436987495615]
[4,"wt 0h",58470171.73,94304728.92,0.6200131467383894,1,100]
[5,"wt 2h",43423780.33,96344569.92,0.45071331333003056,0.7269415426124927,72.69415426124927]
[6,"wt 4h",39788157.67,87255334.92,0.4559968477168731,0.7354631915720944,73.54631915720944]
[7,"SHSY5Y KO",52856553.73,66550589.92,0.7942311825265335]
[8,"SHSY5Y wt",55762640.13,98656977.92,0.5652173957245822]
[9,"SHSY5Y wt",27534263.6,57533384.92,0.47857889186054864]
[null,"WB2"]
[1,"KO 0h",29727232.88,93773006.16,0.31701268944367605,1,100]
[2,"KO 2h",32916936.24,75275115.16,0.43728842088164,1.3794035237170954,137.94035237170954]
[3,"KO 4h",39336165.22,76148441.16,0.5165721664262103,1.629499965230856,162.9499965230856]
[4,"wt 0h",54761658.33,94037616.16,0.5823377980661053,1,100]
[5,"wt 2h",36203880.65,86013491.16,0.4209093266852116,0.7227923862799495,72.27923862799494]
[6,"wt 4h",39331816.06,81523082.16,0.48246232867896277,0.828492208957034,82.8492208957034]
[7,"SHSY5Y KO",39044701.92,66544457.16,0.586746118104482]
[8,"SHSY5Y wt",45529051.99,101885816.16,0.4468634958815253]
[9,"SHSY5Y wt",35588008.07,57388437.16,0.6201250605723936]
[null,"WB3"]
[1,"KO 0h",32079871.75,59447371.25,0.5396348244751025,1,100]
[2,"KO 2h",41263266.04,54391902.25,0.7586288460797489,1.4058189198920952,140.5818919892095]
[3,"KO 4h",43018144.73,54457566.25,0.7899388035909518,1.4638395592043518,146.38395592043517]
[4,"wt 0h",55223854.85,89268487.25,0.6186265338555964,1,100]
[5,"wt 2h",45900878.12,73870870.25,0.6213664190588034,1.004428981062501,100.44289810625008]
[6,"wt 4h",46291874.08,79034393.25,0.5857180928000608,0.9468040259275118,94.68040259275118]
[7,"SHSY5Y wt",47505959.27,50600870.25,0.9388368033057694]
[8,"SHSY5Y wt",51230562.81,82557631.25,0.6205430319925755]
[null,"WB4"]
[null,"KO 0h",29000549.19,71009032.38,0.40840648320351053,1,100]
[null,"KO 2h",31920204.57,48561469.38,0.6573154597160173,1.6094638228073244,160.94638228073245]
[null,"KO 4h",39265225.39,46067425.38,0.8523425189515116,2.086995564482227,208.69955644822272]
[null,"wt 0h",46560522.22,48978607.38,0.9506297690083486,1,100]
[null,"wt 2h",37164193.58,53772698.38,0.691134994144588,0.7270285621978227,72.70285621978228]
[null,"wt 4h",29821602.82,56852259.38,0.5245456054907628,0.5517874808801155,55.17874808801155]
[null,"SHSY5Y wt",26423376.31,52468123.38,0.5036081835561163]
[null,"SHSY5Y wt",38435971.1,79444984.38,0.48380613829758806]
[]
[]
["WB 3",{"$nulls":6},"WB 4"]
{"$rows_empty":22}
["Quantification Data: "]
["WB 3: ",{"$nulls":6},"WB 4: "]
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[5,"SH-SY5Y alt 2 h",{"v":2436228,"d":"2,436,228.00"},{"v":2842306,"d":"2,842,306.00"},0.8571307945027734,1.490622293008541]
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{"$rows_empty":7}
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{"$rows_empty":26}
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[2,"SH-SY5Y RNF170 KO 2 h",{"v":1820829,"d":"1,820,829.00"},{"v":4748765.647059,"d":"4,748,765.65"},0.3834320611562867,0.6450042839902161,null,2,"SH-SY5Y Cl. 71 + RNF170 WT 2 h",{"v":1792581.384615,"d":"1,792,581.38"},{"v":2737238.08,"d":"2,737,238.08"},0.6548869087101843,0.6689520628763215]
[3,"SH-SY5Y RNF170 KO 4 h",{"v":1721706.45,"d":"1,721,706.45"},{"v":4478733.647059,"d":"4,478,733.65"},0.3844181381785393,0.6466630495659983,null,3,"SH-SY5Y Cl. 71 + RNF170 WT 4 h",{"v":1717555.153846,"d":"1,717,555.15"},{"v":2763486.08,"d":"2,763,486.08"},0.6215175702444645,0.6348660435857143]
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[5,"SH-SY5Y alt 2 h",{"v":1113664.9,"d":"1,113,664.90"},{"v":4492525.647059,"d":"4,492,525.65"},0.24789283077973137,0.6739655012790677]
[6,"SH-SY5Y alt 4 h",{"v":1212213.6,"d":"1,212,213.60"},{"v":4630025.176471,"d":"4,630,025.18"},0.2618157685535412,0.7118188740712036]
{"$rows_empty":7}
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{"$rows_empty":21}
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["WB 9: ",{"$nulls":6},"WB 10: "]
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[2,"SH-SY5Y RNF170 KO 2 h",{"v":2552156,"d":"2,552,156.00"},{"v":2617161.56,"d":"2,617,161.56"},0.9751618085052418,0.5763744617029384,null,2,"SH-SY5Y Cl. 71 + RNF170 WT 2 h",{"v":1615138.56,"d":"1,615,138.56"},{"v":2261601.6,"d":"2,261,601.60"},0.7141569761889096,0.9189861198501227]
[3,"SH-SY5Y RNF170 KO 4 h",{"v":1872260,"d":"1,872,260.00"},{"v":2038448.88,"d":"2,038,448.88"},0.9184728733545676,0.5428681715703639,null,3,"SH-SY5Y Cl. 71 + RNF170 WT 4 h",{"v":1783217.28,"d":"1,783,217.28"},{"v":1951997.6,"d":"1,951,997.60"},0.9135345658211874,1.1755476932720004]
[4,"SH-SY5Y alt 0 h",{"v":3370839.652174,"d":"3,370,839.65"},{"v":3619335.71,"d":"3,619,335.71"},0.9313420810511109,1]
[5,"SH-SY5Y alt 2 h",{"v":2028642.956522,"d":"2,028,642.96"},{"v":3403898.83,"d":"3,403,898.83"},0.5959762783319855,0.63991125329521]
[6,"SH-SY5Y alt 4 h",{"v":1986613.043478,"d":"1,986,613.04"},{"v":2326529.17,"d":"2,326,529.17"},0.8538956094317958,0.916844225988469]
{"$rows_empty":7}
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{"$rows_empty":25}
["Quantification Data: "]
["WB 11: ",{"$nulls":6},"WB 12: "]
[null,"Cell lines","IP3R-1 ","Vinculin ","normalized to Vinculin","each sample normalized to t=0",null,null,"Cell lines","IP3R-1 ","Vinculin ","normalized to Vinculin","each sample normalized to t=0"]
[1,"SH-SY5Y RNF170 KO 0 h",{"v":3978620.4,"d":"3,978,620.40"},{"v":5182147.243243,"d":"5,182,147.24"},0.7677551820218389,1,null,1,"SH-SY5Y Cl. 71 + RNF170 WT 0 h",{"v":1283558.857143,"d":"1,283,558.86"},{"v":3434357.641026,"d":"3,434,357.64"},0.3737405917805177,1]
[2,"SH-SY5Y RNF170 KO 2 h",{"v":2784867.45,"d":"2,784,867.45"},{"v":2852507.243243,"d":"2,852,507.24"},0.9762875998288086,1.271613168741905,null,2,"SH-SY5Y Cl. 71 + RNF170 WT 2 h",{"v":1283194.857143,"d":"1,283,194.86"},{"v":3689557.641026,"d":"3,689,557.64"},0.3477909771281325,0.930567845122843]
[3,"SH-SY5Y RNF170 KO 4 h",{"v":2260394.45,"d":"2,260,394.45"},{"v":2198583.243243,"d":"2,198,583.24"},1.0281141080043101,1.33911711972667,null,3,"SH-SY5Y Cl. 71 + RNF170 WT 4 h",{"v":1091772,"d":"1,091,772.00"},{"v":3764261.641026,"d":"3,764,261.64"},0.29003616223191725,0.7760360223388403]
[4,"SH-SY5Y alt 0 h",{"v":1903560.05,"d":"1,903,560.05"},{"v":2484331.243243,"d":"2,484,331.24"},0.7662263456925849,1]
[5,"SH-SY5Y alt 2 h",{"v":1582592.9,"d":"1,582,592.90"},{"v":3651707.243243,"d":"3,651,707.24"},0.4333843855989218,0.5656088282988883]
[6,"SH-SY5Y alt 4 h",{"v":2094602.85,"d":"2,094,602.85"},{"v":2828891.243243,"d":"2,828,891.24"},0.7404324415097618,0.9663364431048006]
{"$rows_empty":9}
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{"$rows_empty":19}
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["WB 13"]
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["KO 2h",null,51271143.27,87685995.92,null,0.5847130175356284,null,1.520031527073473,null,152.0031527073473]
["KO 4h",null,56523189,80716041.92,null,0.7002720606149365,null,1.0849436987495615,null,108.49436987495615]
["wt 0h",null,58470171.73,94304728.92,null,0.6200131467383894,null,1,null,100]
["wt 2h",null,43423780.33,96344569.92,null,0.45071331333003056,null,0.7269415426124927,null,72.69415426124927]
["wt 4h",null,39788157.67,87255334.92,null,0.4559968477168731,null,0.7354631915720944,null,73.54631915720944]
["SHSY5Y KO",null,52856553.73,66550589.92,null,0.7942311825265335]
["SHSY5Y wt",null,55762640.13,98656977.92,null,0.5652173957245822]
["SHSY5Y wt",null,27534263.6,57533384.92,null,0.47857889186054864]
["WB 14"]
["KO 0h",null,29727232.88,93773006.16,null,0.31701268944367605,null,1,null,100]
["KO 2h",null,32916936.24,75275115.16,null,0.43728842088164,null,1.3794035237170954,null,137.94035237170954]
["KO 4h",null,39336165.22,76148441.16,null,0.5165721664262103,null,1.629499965230856,null,162.9499965230856]
["wt 0h",null,54761658.33,94037616.16,null,0.5823377980661053,null,1,null,100]
["wt 2h",null,36203880.65,86013491.16,null,0.4209093266852116,null,0.7227923862799495,null,72.27923862799494]
["wt 4h",null,39331816.06,81523082.16,null,0.48246232867896277,null,0.828492208957034,null,82.8492208957034]
["SHSY5Y KO",null,39044701.92,66544457.16,null,0.586746118104482]
["SHSY5Y wt",null,45529051.99,101885816.16,null,0.4468634958815253]
["SHSY5Y wt",null,35588008.07,57388437.16,null,0.6201250605723936]
["WB 15"]
["KO 0h",null,32079871.75,59447371.25,null,0.5396348244751025,null,1,null,100]
["KO 2h",null,41263266.04,54391902.25,null,0.7586288460797489,null,1.4058189198920952,null,140.5818919892095]
["KO 4h",null,43018144.73,54457566.25,null,0.7899388035909518,null,1.4638395592043518,null,146.38395592043517]
["wt 0h",null,55223854.85,89268487.25,null,0.6186265338555964,null,1,null,100]
["wt 2h",null,45900878.12,73870870.25,null,0.6213664190588034,null,1.004428981062501,null,100.44289810625008]
["wt 4h",null,46291874.08,79034393.25,null,0.5857180928000608,null,0.9468040259275118,null,94.68040259275118]
["SHSY5Y wt",null,47505959.27,50600870.25,null,0.9388368033057694]
["SHSY5Y wt",null,51230562.81,82557631.25,null,0.6205430319925755]
["WB 16"]
["KO 0h",null,29000549.19,71009032.38,null,0.40840648320351053,null,1,null,100]
["KO 2h",null,31920204.57,48561469.38,null,0.6573154597160173,null,1.6094638228073244,null,160.94638228073245]
["KO 4h",null,39265225.39,46067425.38,null,0.8523425189515116,null,2.086995564482227,null,208.69955644822272]
["wt 0h",null,46560522.22,48978607.38,null,0.9506297690083486,null,1,null,100]
["wt 2h",null,37164193.58,53772698.38,null,0.691134994144588,null,0.7270285621978227,null,72.70285621978228]
["wt 4h",null,29821602.82,56852259.38,null,0.5245456054907628,null,0.5517874808801155,null,55.17874808801155]
["SHSY5Y wt",null,26423376.31,52468123.38,null,0.5036081835561163]
["SHSY5Y wt",null,38435971.1,79444984.38,null,0.48380613829758806]
[]
[]
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{"$rows_empty":22}
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[null,"IPR31","Vinculin","IP3R1 / Vinculin",null,"normalized to 1",null,"normalized to 100%"]
["WB 17"]
["wt 0h",31506983,50880328.08,0.6192370251713204,null,{"v":1,"d":"1.000"},null,{"v":100,"d":"100.000"}]
["wt 2h",28735247.67,49558897.08,0.5798201607193637,null,{"v":0.9363460793691213,"d":"0.936"},null,{"v":93.63460793691213,"d":"93.635"}]
["wt 4h",21412967,42102997.08,0.5085853379823098,null,{"v":0.8213096396191792,"d":"0.821"},null,{"v":82.13096396191793,"d":"82.131"}]
["WB 18"]
["wt 0h",26368893,37866406.05,0.6963664036450061,null,{"v":1,"d":"1.000"},null,{"v":100,"d":"100.000"}]
["wt 2h",16059132,50793148.05,0.3161672905997407,null,{"v":0.45402433107746043,"d":"0.454"},null,{"v":45.40243310774604,"d":"45.402"}]
["wt 4h",15780072,40574766.05,0.38891344390142213,null,{"v":0.5584896713364169,"d":"0.558"},null,{"v":55.84896713364169,"d":"55.849"}]
["WB 19"]
["wt 0h",20046014.18,33815351.88,0.5928080905719085,null,{"v":1,"d":"1.000"},null,{"v":100,"d":"100.000"}]
["wt 2h",17811871.15,33242686.88,0.5358132215454661,null,{"v":0.9038561215123482,"d":"0.904"},null,{"v":90.38561215123482,"d":"90.386"}]
["wt 4h",17426643.14,27587724.88,0.631681054374789,null,{"v":1.0655742801441492,"d":"1.066"},null,{"v":106.55742801441492,"d":"106.557"}]

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