Pathway ID Pathway description Pathway module g:Profiler P-value GO:0048732 gland development organ development 1.68E-16 GO:1902806 regulation of cell cycle G1/S phase transition cell cycle regulation; DNA damage checkpoint 7.79E-14 GO:0071214 cellular response to abiotic stimulus radiation response 1.13E-13 GO:0071900 regulation of protein serine/threonine kinase activity kinase signaling 2.52E-13 GO:0070997 neuron death neuron death 3.62E-13 GO:0044843 cell cycle G1/S phase transition cell cycle regulation; DNA damage checkpoint 4.16E-13 GO:1901214 regulation of neuron death neuron death 7.95E-13 GO:0050673 epithelial cell proliferation epithelial cell proliferation 3.51E-12 GO:0051402 neuron apoptotic process neuron death 9.36E-12 GO:0043523 regulation of neuron apoptotic process neuron death 3.29E-11 GO:0050678 regulation of epithelial cell proliferation epithelial cell proliferation 4.20E-11 GO:0045860 positive regulation of protein kinase activity kinase signaling 5.87E-11 GO:1901987 regulation of cell cycle phase transition cell cycle regulation; DNA damage checkpoint 5.99E-11 GO:0016049 cell growth cell growth 1.23E-10 GO:0016570 histone modification histone modification 1.67E-10 GO:0051052 regulation of DNA metabolic process DNA biosynthesis 2.41E-10 GO:2000045 regulation of G1/S transition of mitotic cell cycle cell cycle regulation; DNA damage checkpoint 4.21E-10 GO:0006338 chromatin remodeling chromatin remodeling 6.96E-10 GO:0000082 G1/S transition of mitotic cell cycle cell cycle regulation; DNA damage checkpoint 1.12E-09 REAC:8848021 Signaling by PTK6 Ras signaling 1.25E-09 GO:0048608 reproductive structure development organ development 1.34E-09 GO:0009411 response to UV radiation response 1.39E-09 GO:0061458 reproductive system development organ development 1.57E-09 GO:0009314 response to radiation radiation response 1.84E-09 GO:1902807 negative regulation of cell cycle G1/S phase transition cell cycle regulation; DNA damage checkpoint 5.00E-09 GO:0010948 negative regulation of cell cycle process cell cycle regulation; DNA damage checkpoint 5.65E-09 REAC:8849471 "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases" Ras signaling 6.51E-09 GO:0016055 Wnt signaling pathway Wnt signaling 7.00E-09 GO:0198738 cell-cell signaling by wnt Wnt signaling 7.26E-09 GO:0048025 "negative regulation of mRNA splicing, via spliceosome" RNA processing and splicing 7.64E-09 GO:0002521 leukocyte differentiation hemopoiesis 7.79E-09 GO:0009416 response to light stimulus radiation response 1.08E-08 REAC:72163 mRNA Splicing - Major Pathway RNA processing and splicing 1.20E-08 GO:0050680 negative regulation of epithelial cell proliferation epithelial cell proliferation 1.33E-08 GO:0070482 response to oxygen levels hypoxia response 1.82E-08 GO:1903312 negative regulation of mRNA metabolic process RNA processing and splicing 2.02E-08 GO:0018205 peptidyl-lysine modification histone modification 2.32E-08 REAC:72172 mRNA Splicing RNA processing and splicing 3.06E-08 GO:0033119 negative regulation of RNA splicing RNA processing and splicing 4.65E-08 GO:1901990 regulation of mitotic cell cycle phase transition cell cycle regulation; DNA damage checkpoint 5.06E-08 GO:1903706 regulation of hemopoiesis hemopoiesis 6.53E-08 GO:0000377 "RNA splicing, via transesterification reactions with bulged adenosine as nucleophile" RNA processing and splicing 7.43E-08 GO:0000398 "mRNA splicing, via spliceosome" RNA processing and splicing 7.43E-08 GO:0097193 intrinsic apoptotic signaling pathway apoptotic signaling 7.44E-08 GO:0045930 negative regulation of mitotic cell cycle cell cycle regulation; DNA damage checkpoint 7.80E-08 GO:1901216 positive regulation of neuron death neuron death 8.48E-08 GO:0000375 "RNA splicing, via transesterification reactions" RNA processing and splicing 8.48E-08 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle cell cycle regulation; DNA damage checkpoint 8.57E-08 GO:1903311 regulation of mRNA metabolic process RNA processing and splicing 9.11E-08 GO:0035239 tube morphogenesis organ development 1.31E-07 GO:0050686 negative regulation of mRNA processing RNA processing and splicing 1.48E-07 REAC:166520 Signalling by NGF signal transduction 1.81E-07 GO:0043525 positive regulation of neuron apoptotic process neuron death 1.95E-07 GO:0007050 cell cycle arrest cell cycle regulation; DNA damage checkpoint 2.24E-07 GO:0060537 muscle tissue development heart development 2.83E-07 REAC:5637810 Constitutive Signaling by EGFRvIII signal transduction 2.94E-07 REAC:5637812 Signaling by EGFRvIII in Cancer signal transduction 2.94E-07 GO:0010332 response to gamma radiation radiation response 3.12E-07 REAC:3769402 Deactivation of the beta-catenin transactivating complex Wnt signaling 3.15E-07 GO:0060562 epithelial tube morphogenesis organ development 3.52E-07 GO:0045165 cell fate commitment cell fate 3.80E-07 GO:0042110 T cell activation hemopoiesis 4.32E-07 GO:0030098 lymphocyte differentiation hemopoiesis 4.51E-07 GO:0042063 gliogenesis organ development 4.64E-07 GO:0071902 positive regulation of protein serine/threonine kinase activity kinase signaling 6.23E-07 REAC:2424491 DAP12 signaling signal transduction 6.30E-07 GO:0007265 Ras protein signal transduction Ras signaling 7.29E-07 GO:1901988 negative regulation of cell cycle phase transition cell cycle regulation; DNA damage checkpoint 7.55E-07 REAC:72203 Processing of Capped Intron-Containing Pre-mRNA RNA processing and splicing 7.92E-07 GO:0001666 response to hypoxia hypoxia response 9.20E-07 GO:0001654 eye development eye development 9.56E-07 REAC:3247509 chromatin modifying enzymes chromatin organization 9.72E-07 REAC:4839726 chromatin organization chromatin organization 9.72E-07 REAC:3700989 Transcriptional Regulation by TP53 cell cycle regulation; DNA damage checkpoint 1.04E-06 REAC:2172127 DAP12 interactions signal transduction 1.04E-06 GO:0036293 response to decreased oxygen levels hypoxia response 1.25E-06 REAC:1227986 Signaling by ERBB2 signal transduction 1.36E-06 GO:0045926 negative regulation of growth cell growth 1.39E-06 REAC:1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants signal transduction 1.56E-06 REAC:1643713 Signaling by EGFR in Cancer signal transduction 1.56E-06 REAC:5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer signal transduction 1.56E-06 GO:0043010 camera-type eye development eye development 1.66E-06 GO:0014706 striated muscle tissue development heart development 1.67E-06 GO:0060767 epithelial cell proliferation involved in prostate gland development prostate gland development 1.83E-06 REAC:8853334 Signaling by FGFR3 fusions in cancer signal transduction 2.05E-06 GO:1901215 negative regulation of neuron death neuron death 2.07E-06 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity kinase signaling 2.18E-06 REAC:187037 NGF signaling via TRKA from the plasma membrane signal transduction 2.21E-06 GO:1904837 beta-catenin-TCF complex assembly Wnt signaling 2.45E-06 GO:0010001 glial cell differentiation organ development 2.66E-06 GO:1904030 negative regulation of cyclin-dependent protein kinase activity kinase signaling 2.86E-06 REAC:2454202 Fc epsilon receptor (FCERI) signaling signal transduction 2.98E-06 GO:0008380 RNA splicing RNA processing and splicing 3.27E-06 GO:0030900 forebrain development brain development 3.28E-06 GO:0030850 prostate gland development prostate gland development 3.39E-06 GO:0060249 anatomical structure homeostasis tissue homeostasis 3.64E-06 REAC:5655291 Signaling by FGFR4 in disease signal transduction 3.73E-06 GO:0048024 "regulation of mRNA splicing, via spliceosome" RNA processing and splicing 3.86E-06 GO:0002768 immune response-regulating cell surface receptor signaling pathway signal transduction 3.89E-06 GO:0001558 regulation of cell growth cell growth 4.45E-06 GO:0048545 response to steroid hormone androgen receptor signaling 4.60E-06 GO:0001894 tissue homeostasis tissue homeostasis 4.67E-06 GO:1903829 positive regulation of cellular protein localization protein localization to nucleus 4.92E-06 GO:0018394 peptidyl-lysine acetylation histone modification 5.24E-06 GO:0043484 regulation of RNA splicing RNA processing and splicing 5.45E-06 GO:0010717 regulation of epithelial to mesenchymal transition organ development 5.53E-06 GO:0072331 signal transduction by p53 class mediator cell cycle regulation; DNA damage checkpoint 5.54E-06 GO:0001667 ameboidal-type cell migration cell migration 6.08E-06 REAC:201722 Formation of the beta-catenin:TCF transactivating complex Wnt signaling 6.42E-06 GO:1901991 negative regulation of mitotic cell cycle phase transition cell cycle regulation; DNA damage checkpoint 6.66E-06 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity kinase signaling 7.50E-06 GO:0019827 stem cell population maintenance stem cell population maintenance 8.88E-06 GO:0071478 cellular response to radiation radiation response 9.03E-06 GO:0048871 multicellular organismal homeostasis tissue homeostasis 9.06E-06 GO:0010812 negative regulation of cell-substrate adhesion cell-substrate adhesion 9.53E-06 GO:0030099 myeloid cell differentiation hemopoiesis 9.73E-06 GO:0098727 maintenance of cell number stem cell population maintenance 1.00E-05 GO:1904029 regulation of cyclin-dependent protein kinase activity kinase signaling 1.01E-05 GO:0030335 positive regulation of cell migration cell migration 1.06E-05 GO:0001942 hair follicle development epidermis development 1.33E-05 GO:0007173 epidermal growth factor receptor signaling pathway signal transduction 1.35E-05 GO:0045787 positive regulation of cell cycle cell cycle regulation; DNA damage checkpoint 1.48E-05 GO:0051348 negative regulation of transferase activity kinase signaling 1.58E-05 GO:0048568 embryonic organ development organ development 1.58E-05 GO:0022404 molting cycle process epidermis development 1.60E-05 GO:0022405 hair cycle process epidermis development 1.60E-05 REAC:1433557 Signaling by SCF-KIT signal transduction 1.62E-05 GO:2000147 positive regulation of cell motility cell migration 1.68E-05 GO:0001837 epithelial to mesenchymal transition organ development 1.77E-05 GO:0060070 canonical Wnt signaling pathway Wnt signaling 1.80E-05 REAC:5654696 Downstream signaling of activated FGFR2 signal transduction 1.82E-05 REAC:5654708 Downstream signaling of activated FGFR3 signal transduction 1.82E-05 REAC:5654716 Downstream signaling of activated FGFR4 signal transduction 1.82E-05 GO:0042326 negative regulation of phosphorylation kinase signaling 1.94E-05 GO:0007409 axonogenesis signal transduction 2.00E-05 REAC:5654687 Downstream signaling of activated FGFR1 signal transduction 2.04E-05 REAC:5654743 Signaling by FGFR4 signal transduction 2.04E-05 REAC:5654741 Signaling by FGFR3 signal transduction 2.12E-05 GO:0006473 protein acetylation histone modification 2.20E-05 GO:0006397 mRNA processing RNA processing and splicing 2.23E-05 GO:0030518 intracellular steroid hormone receptor signaling pathway androgen receptor signaling 2.31E-05 GO:0051272 positive regulation of cellular component movement cell migration 2.38E-05 GO:0010632 regulation of epithelial cell migration cell migration 2.45E-05 REAC:5654736 Signaling by FGFR1 signal transduction 2.47E-05 GO:0003179 heart valve morphogenesis organ development 2.53E-05 GO:0010631 epithelial cell migration cell migration 2.57E-05 GO:0045862 positive regulation of proteolysis proteasomal protein catabolism 2.86E-05 REAC:186763 Downstream signal transduction signal transduction 2.87E-05 GO:0090132 epithelium migration cell migration 2.92E-05 GO:0007569 cell aging cell cycle regulation; DNA damage checkpoint 2.93E-05 GO:0098773 skin epidermis development epidermis development 3.18E-05 GO:0043524 negative regulation of neuron apoptotic process neuron death 3.19E-05 REAC:195721 Signaling by Wnt Wnt signaling 3.76E-05 GO:0090130 tissue migration cell migration 3.77E-05 GO:0031589 cell-substrate adhesion cell-substrate adhesion 3.78E-05 GO:0090150 establishment of protein localization to membrane apoptotic signaling 3.79E-05 GO:0040017 positive regulation of locomotion cell migration 3.96E-05 GO:2001233 regulation of apoptotic signaling pathway apoptotic signaling 4.04E-05 REAC:201681 TCF dependent signaling in response to WNT Wnt signaling 4.05E-05 REAC:177929 Signaling by EGFR signal transduction 4.43E-05 GO:0001655 urogenital system development organ development 4.51E-05 GO:0042176 regulation of protein catabolic process proteasomal protein catabolism 4.71E-05 GO:0038128 ERBB2 signaling pathway signal transduction 5.01E-05 GO:0003170 heart valve development organ development 5.01E-05 GO:0030521 androgen receptor signaling pathway androgen receptor signaling 5.11E-05 GO:0016573 histone acetylation histone modification 5.21E-05 GO:0033673 negative regulation of kinase activity kinase signaling 5.44E-05 GO:0061564 axon development signal transduction 5.48E-05 GO:0038127 ERBB signaling pathway signal transduction 5.52E-05 GO:0048754 branching morphogenesis of an epithelial tube organ development 5.52E-05 GO:0010212 response to ionizing radiation radiation response 5.86E-05 REAC:5654738 Signaling by FGFR2 signal transduction 5.87E-05 GO:0044089 positive regulation of cellular component biogenesis protein compex assembly 5.94E-05 GO:0043405 regulation of MAP kinase activity kinase signaling 6.15E-05 GO:0022407 regulation of cell-cell adhesion hemopoiesis 6.36E-05 GO:0018393 internal peptidyl-lysine acetylation histone modification 6.58E-05 REAC:210993 Tie2 Signaling signal transduction 6.62E-05 REAC:186797 Signaling by PDGF signal transduction 6.73E-05 GO:0050684 regulation of mRNA processing RNA processing and splicing 7.04E-05 REAC:190236 Signaling by FGFR signal transduction 7.21E-05 GO:0034644 cellular response to UV radiation response 7.70E-05 GO:0007093 mitotic cell cycle checkpoint cell cycle regulation; DNA damage checkpoint 7.80E-05 GO:2001252 positive regulation of chromosome organization histone modification 7.80E-05 GO:0048015 phosphatidylinositol-mediated signaling signal transduction 7.92E-05 GO:0010718 positive regulation of epithelial to mesenchymal transition organ development 7.98E-05 GO:0034968 histone lysine methylation histone modification 8.00E-05 GO:0042303 molting cycle epidermis development 8.59E-05 GO:0042633 hair cycle epidermis development 8.59E-05 GO:0006475 internal protein amino acid acetylation histone modification 8.73E-05 GO:0001709 cell fate determination cell fate 8.98E-05 GO:0048017 inositol lipid-mediated signaling signal transduction 9.07E-05 GO:0043543 protein acylation histone modification 9.92E-05 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway TGFB signaling 1.01E-04 GO:0051961 negative regulation of nervous system development nervous system development 1.04E-04 GO:0009896 positive regulation of catabolic process proteasomal protein catabolism 1.10E-04 GO:0030308 negative regulation of cell growth cell growth 1.21E-04 GO:0030522 intracellular receptor signaling pathway androgen receptor signaling 1.21E-04 REAC:1236394 Signaling by ERBB4 signal transduction 1.28E-04 GO:1900180 regulation of protein localization to nucleus protein localization to nucleus 1.29E-04 GO:0043542 endothelial cell migration cell migration 1.34E-04 GO:0009743 response to carbohydrate response to carbohydrate 1.35E-04 REAC:2179392 EGFR Transactivation by Gastrin signal transduction 1.36E-04 GO:0003002 regionalization pattern specification process 1.41E-04 REAC:1168372 Downstream signaling events of B Cell Receptor (BCR) signal transduction 1.50E-04 GO:0035050 embryonic heart tube development organ development 1.58E-04 GO:0000075 cell cycle checkpoint cell cycle regulation; DNA damage checkpoint 1.60E-04 GO:0018022 peptidyl-lysine methylation histone modification 1.81E-04 REAC:5655332 Signaling by FGFR3 in disease signal transduction 1.98E-04 REAC:8853338 Signaling by FGFR3 point mutants in cancer signal transduction 1.98E-04 GO:0034504 protein localization to nucleus protein localization to nucleus 2.06E-04 GO:0031058 positive regulation of histone modification histone modification 2.11E-04 GO:0007568 aging cell cycle regulation; DNA damage checkpoint 2.14E-04 GO:0071901 negative regulation of protein serine/threonine kinase activity kinase signaling 2.19E-04 GO:0038095 Fc-epsilon receptor signaling pathway signal transduction 2.35E-04 GO:0007389 pattern specification process pattern specification process 2.49E-04 GO:0003007 heart morphogenesis organ development 2.51E-04 GO:0051249 regulation of lymphocyte activation hemopoiesis 2.53E-04 GO:0032147 activation of protein kinase activity kinase signaling 2.54E-04 GO:0006479 protein methylation histone modification 2.72E-04 GO:0008213 protein alkylation histone modification 2.72E-04 REAC:198203 PI3K/AKT activation signal transduction 2.92E-04 GO:0051568 histone H3-K4 methylation histone modification 2.99E-04 GO:0061138 morphogenesis of a branching epithelium organ development 2.99E-04 GO:0050863 regulation of T cell activation hemopoiesis 3.11E-04 GO:0006469 negative regulation of protein kinase activity kinase signaling 3.30E-04 GO:0033157 regulation of intracellular protein transport protein localization to nucleus 3.38E-04 GO:0010810 regulation of cell-substrate adhesion cell-substrate adhesion 3.44E-04 GO:0035904 aorta development organ development 3.46E-04 GO:1905269 positive regulation of chromatin organization histone modification 3.73E-04 GO:0009749 response to glucose response to carbohydrate 3.96E-04 GO:0016571 histone methylation histone modification 4.00E-04 GO:0043401 steroid hormone mediated signaling pathway androgen receptor signaling 4.14E-04 GO:1902105 regulation of leukocyte differentiation hemopoiesis 4.31E-04 GO:0071383 cellular response to steroid hormone stimulus androgen receptor signaling 4.31E-04 GO:2000027 regulation of organ morphogenesis organ development 4.31E-04 GO:0048762 mesenchymal cell differentiation organ development 4.53E-04 REAC:4420097 VEGFA-VEGFR2 Pathway signal transduction 4.82E-04 GO:0009746 response to hexose response to carbohydrate 4.96E-04 GO:0043535 regulation of blood vessel endothelial cell migration cell migration 5.23E-04 GO:0050768 negative regulation of neurogenesis nervous system development 5.26E-04 GO:0001933 negative regulation of protein phosphorylation kinase signaling 5.28E-04 GO:0043406 positive regulation of MAP kinase activity kinase signaling 5.37E-04 GO:0001763 morphogenesis of a branching structure organ development 5.41E-04 GO:0043410 positive regulation of MAPK cascade kinase signaling 5.48E-04 GO:1903037 regulation of leukocyte cell-cell adhesion hemopoiesis 5.69E-04 GO:0001953 negative regulation of cell-matrix adhesion cell-substrate adhesion 6.28E-04 REAC:194138 Signaling by VEGF signal transduction 6.30E-04 GO:0034284 response to monosaccharide response to carbohydrate 6.44E-04 GO:0090399 replicative senescence cell cycle regulation; DNA damage checkpoint 6.50E-04 GO:0021537 telencephalon development brain development 6.60E-04 GO:0060485 mesenchyme development organ development 6.60E-04 GO:0045732 positive regulation of protein catabolic process proteasomal protein catabolism 6.67E-04 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage apoptotic signaling 6.76E-04 CORUM:570 p300-CBP-p270-SWI/SNF complex chromatin organization 6.79E-04 GO:0032388 positive regulation of intracellular transport protein localization to nucleus 7.26E-04 GO:0007160 cell-matrix adhesion cell-substrate adhesion 7.32E-04 GO:0003279 cardiac septum development organ development 7.54E-04 GO:0035107 appendage morphogenesis limb development 7.74E-04 GO:0035108 limb morphogenesis limb development 7.74E-04 GO:0042733 embryonic digit morphogenesis limb development 7.88E-04 GO:0035148 tube formation organ development 8.16E-04 GO:0006977 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest" cell cycle regulation; DNA damage checkpoint 8.69E-04 GO:2000826 regulation of heart morphogenesis organ development 8.71E-04 GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint cell cycle regulation; DNA damage checkpoint 9.57E-04 GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint cell cycle regulation; DNA damage checkpoint 9.57E-04 GO:0010165 response to X-ray cell cycle regulation; DNA damage checkpoint 1.02E-03 GO:0006606 protein import into nucleus protein localization to nucleus 1.04E-03 GO:0044744 protein targeting to nucleus protein localization to nucleus 1.04E-03 REAC:5626467 RHO GTPases activate IQGAPs Ras signaling 1.05E-03 GO:0018105 peptidyl-serine phosphorylation serine phosphorylation 1.08E-03 GO:0002429 immune response-activating cell surface receptor signaling pathway signal transduction 1.09E-03 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint cell cycle regulation; DNA damage checkpoint 1.16E-03 GO:1902402 signal transduction involved in mitotic DNA damage checkpoint cell cycle regulation; DNA damage checkpoint 1.16E-03 GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint cell cycle regulation; DNA damage checkpoint 1.16E-03 GO:0051054 positive regulation of DNA metabolic process DNA biosynthesis 1.20E-03 REAC:72187 mRNA 3'-end processing RNA processing and splicing 1.21E-03 GO:1905477 positive regulation of protein localization to membrane protein localization to membrane 1.32E-03 GO:0035265 organ growth heart development 1.35E-03 GO:0007159 leukocyte cell-cell adhesion hemopoiesis 1.37E-03 GO:0072401 signal transduction involved in DNA integrity checkpoint cell cycle regulation; DNA damage checkpoint 1.39E-03 GO:0072422 signal transduction involved in DNA damage checkpoint cell cycle regulation; DNA damage checkpoint 1.39E-03 GO:0071482 cellular response to light stimulus radiation response 1.41E-03 GO:0060795 cell fate commitment involved in formation of primary germ layer cell fate 1.44E-03 GO:0043414 macromolecule methylation histone modification 1.45E-03 GO:0030330 "DNA damage response, signal transduction by p53 class mediator" cell cycle regulation; DNA damage checkpoint 1.50E-03 GO:0072395 signal transduction involved in cell cycle checkpoint cell cycle regulation; DNA damage checkpoint 1.51E-03 GO:0021915 neural tube development organ development 1.63E-03 GO:0030217 T cell differentiation hemopoiesis 1.69E-03 GO:0003205 cardiac chamber development organ development 1.70E-03 GO:0046328 regulation of JNK cascade kinase signaling 1.79E-03 GO:0018209 peptidyl-serine modification serine phosphorylation 1.87E-03 REAC:1963640 GRB2 events in ERBB2 signaling signal transduction 1.88E-03 GO:0007219 Notch signaling pathway Notch signaling 1.88E-03 GO:0006913 nucleocytoplasmic transport RNA processing and splicing 1.93E-03 REAC:4791275 Signaling by WNT in cancer Wnt signaling 1.95E-03 GO:0031571 mitotic G1 DNA damage checkpoint cell cycle regulation; DNA damage checkpoint 1.96E-03 GO:0044819 mitotic G1/S transition checkpoint cell cycle regulation; DNA damage checkpoint 1.96E-03 GO:0010721 negative regulation of cell development nervous system development 2.02E-03 GO:0009755 hormone-mediated signaling pathway androgen receptor signaling 2.04E-03 GO:0014065 phosphatidylinositol 3-kinase signaling signal transduction 2.06E-03 GO:0044783 G1 DNA damage checkpoint cell cycle regulation; DNA damage checkpoint 2.13E-03 GO:2000136 regulation of cell proliferation involved in heart morphogenesis organ development 2.13E-03 GO:0006369 termination of RNA polymerase II transcription RNA processing and splicing 2.15E-03 GO:0021543 pallium development brain development 2.25E-03 GO:0071560 cellular response to transforming growth factor beta stimulus TGFB signaling 2.25E-03 GO:0033044 regulation of chromosome organization histone modification 2.32E-03 GO:0003151 outflow tract morphogenesis organ development 2.34E-03 CORUM:1238 PBAF complex (Polybromo- and BAF containing complex) chromatin organization 2.37E-03 CORUM:556 PBAF complex (Polybromo- and BAF containing complex) PBAF complex 2.37E-03 REAC:1250342 PI3K events in ERBB4 signaling signal transduction 2.47E-03 REAC:1257604 PIP3 activates AKT signaling signal transduction 2.47E-03 REAC:5654689 PI-3K cascade:FGFR1 signal transduction 2.47E-03 REAC:5654695 PI-3K cascade:FGFR2 signal transduction 2.47E-03 REAC:5654710 PI-3K cascade:FGFR3 signal transduction 2.47E-03 REAC:5654720 PI-3K cascade:FGFR4 signal transduction 2.47E-03 GO:0021987 cerebral cortex development brain development 2.49E-03 GO:0071559 response to transforming growth factor beta TGFB signaling 2.52E-03 GO:0048736 appendage development limb development 2.58E-03 GO:0060173 limb development limb development 2.58E-03 GO:0042306 regulation of protein import into nucleus protein localization to nucleus 2.58E-03 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process proteasomal protein catabolism 2.68E-03 GO:0061323 cell proliferation involved in heart morphogenesis organ development 2.73E-03 GO:0048562 embryonic organ morphogenesis organ development 2.78E-03 REAC:109688 Cleavage of Growing Transcript in the Termination Region RNA processing and splicing 2.82E-03 REAC:73856 RNA Polymerase II Transcription Termination RNA processing and splicing 2.82E-03 REAC:180292 GAB1 signalosome signal transduction 2.92E-03 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process proteasomal protein catabolism 2.93E-03 GO:0055017 cardiac muscle tissue growth heart development 2.94E-03 GO:1904589 regulation of protein import protein localization to nucleus 2.94E-03 GO:0035019 somatic stem cell population maintenance stem cell population maintenance 3.00E-03 CORUM:1181 C complex spliceosome RNA processing and splicing 3.02E-03 GO:0003231 cardiac ventricle development organ development 3.34E-03 GO:0038093 Fc receptor signaling pathway signal transduction 3.36E-03 GO:0042770 signal transduction in response to DNA damage cell cycle regulation; DNA damage checkpoint 3.40E-03 REAC:5655302 Signaling by FGFR1 in disease signal transduction 3.42E-03 GO:2001235 positive regulation of apoptotic signaling pathway apoptotic signaling 3.48E-03 GO:0010594 regulation of endothelial cell migration cell migration 3.59E-03 GO:0043534 blood vessel endothelial cell migration cell migration 3.70E-03 GO:0001838 embryonic epithelial tube formation organ development 3.79E-03 CORUM:149 PBAF complex (Polybromo- and BAF containing complex) PBAF complex 3.89E-03 CORUM:554 PBAF complex (Polybromo- and BAF containing complex) PBAF complex 3.89E-03 GO:0030326 embryonic limb morphogenesis limb development 4.00E-03 GO:0035113 embryonic appendage morphogenesis limb development 4.00E-03 REAC:1980143 Signaling by NOTCH1 Notch signaling 4.29E-03 GO:0031498 chromatin disassembly chromatin organization 4.30E-03 GO:1900182 positive regulation of protein localization to nucleus protein localization to nucleus 4.44E-03 GO:0048709 oligodendrocyte differentiation nervous system development 4.61E-03 GO:0030856 regulation of epithelial cell differentiation organ development 4.68E-03 GO:0017038 protein import protein localization to nucleus 4.80E-03 GO:0060419 heart growth heart development 4.95E-03 GO:0002573 myeloid leukocyte differentiation hemopoiesis 5.04E-03 GO:0006611 protein export from nucleus RNA processing and splicing 5.07E-03 GO:0001708 cell fate specification cell fate 5.16E-03 GO:2000241 regulation of reproductive process prostate gland development 5.19E-03 GO:0090596 sensory organ morphogenesis eye development 5.20E-03 GO:0097194 execution phase of apoptosis apoptotic signaling 5.31E-03 REAC:112399 IRS-mediated signaling signal transduction 5.32E-03 GO:0071456 cellular response to hypoxia hypoxia response 5.46E-03 GO:0010498 proteasomal protein catabolic process proteasomal protein catabolism 5.48E-03 GO:0060840 artery development organ development 5.55E-03 REAC:983705 Signaling by the B Cell Receptor (BCR) signal transduction 5.67E-03 GO:0045637 regulation of myeloid cell differentiation hemopoiesis 5.67E-03 GO:0072175 epithelial tube formation organ development 5.74E-03 GO:0051972 regulation of telomerase activity DNA biosynthesis 5.85E-03 GO:0010035 response to inorganic substance response to metal ion 5.89E-03 GO:0031098 stress-activated protein kinase signaling cascade kinase signaling 5.91E-03 GO:0060038 cardiac muscle cell proliferation heart development 5.95E-03 CORUM:803 BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I chromatin remodeling 6.01E-03 REAC:5621575 CD209 (DC-SIGN) signaling signal transduction 6.01E-03 REAC:2428924 IGF1R signaling cascade signal transduction 6.04E-03 REAC:2428928 IRS-related events triggered by IGF1R signal transduction 6.04E-03 REAC:74751 Insulin receptor signaling cascade signal transduction 6.04E-03 GO:0031056 regulation of histone modification histone modification 6.04E-03 GO:0090068 positive regulation of cell cycle process cell cycle regulation; DNA damage checkpoint 6.10E-03 REAC:2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) signal transduction 6.23E-03 GO:0001889 liver development organ development 6.34E-03 REAC:109606 Intrinsic Pathway for Apoptosis apoptotic signaling 6.37E-03 REAC:5655253 Signaling by FGFR2 in disease signal transduction 6.37E-03 GO:1903362 regulation of cellular protein catabolic process proteasomal protein catabolism 6.50E-03 GO:0071158 positive regulation of cell cycle arrest cell cycle regulation; DNA damage checkpoint 6.52E-03 GO:0090316 positive regulation of intracellular protein transport protein localization to nucleus 6.71E-03 GO:0007254 JNK cascade kinase signaling 6.88E-03 GO:0001656 metanephros development organ development 6.98E-03 GO:0048738 cardiac muscle tissue development heart development 7.15E-03 GO:0036294 cellular response to decreased oxygen levels hypoxia response 7.15E-03 REAC:1250196 SHC1 events in ERBB2 signaling signal transduction 7.30E-03 GO:0051205 protein insertion into membrane protein localization to membrane 7.32E-03 GO:0061008 hepaticobiliary system development organ development 7.34E-03 GO:2000617 positive regulation of histone H3-K9 acetylation histone modification 7.40E-03 GO:0007548 sex differentiation organ development 8.08E-03 GO:0032872 regulation of stress-activated MAPK cascade kinase signaling 8.62E-03 GO:0000380 "alternative mRNA splicing, via spliceosome" RNA processing and splicing 8.90E-03 GO:0070302 regulation of stress-activated protein kinase signaling cascade kinase signaling 8.94E-03 GO:0060541 respiratory system development organ development 8.94E-03 GO:0072080 nephron tubule development organ development 9.05E-03 REAC:157118 Signaling by NOTCH Notch signaling 9.33E-03 GO:0072006 nephron development organ development 9.58E-03 GO:0009952 anterior/posterior pattern specification pattern specification process 9.62E-03 GO:0048592 eye morphogenesis eye development 9.74E-03 GO:0060425 lung morphogenesis organ development 9.80E-03 REAC:2122947 NOTCH1 Intracellular Domain Regulates Transcription Notch signaling 9.90E-03 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process proteasomal protein catabolism 9.97E-03 GO:0051168 nuclear export RNA processing and splicing 9.97E-03 GO:0071453 cellular response to oxygen levels hypoxia response 1.03E-02 GO:0031124 mRNA 3'-end processing RNA processing and splicing 1.03E-02 GO:0032259 methylation histone modification 1.06E-02 GO:0061326 renal tubule development organ development 1.09E-02 GO:1905475 regulation of protein localization to membrane protein localization to membrane 1.12E-02 GO:0031657 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle signal transduction 1.18E-02 REAC:2428933 SHC-related events triggered by IGF1R signal transduction 1.18E-02 GO:2000756 regulation of peptidyl-lysine acetylation histone modification 1.18E-02 REAC:6791312 TP53 Regulates Transcription of Cell Cycle Genes cell cycle regulation; DNA damage checkpoint 1.22E-02 GO:0071248 cellular response to metal ion response to metal ion 1.22E-02 GO:0001952 regulation of cell-matrix adhesion cell-substrate adhesion 1.23E-02 GO:0031331 positive regulation of cellular catabolic process proteasomal protein catabolism 1.23E-02 REAC:5673000 RAF activation signal transduction 1.24E-02 REAC:74752 Signaling by Insulin receptor signal transduction 1.24E-02 CORUM:189 BAF complex chromatin remodeling 1.26E-02 GO:0090398 cellular senescence cell cycle regulation; DNA damage checkpoint 1.29E-02 GO:0008544 epidermis development epidermis development 1.31E-02 GO:0061005 cell differentiation involved in kidney development organ development 1.31E-02 GO:0016331 morphogenesis of embryonic epithelium organ development 1.33E-02 GO:0046686 response to cadmium ion response to metal ion 1.41E-02 GO:0051028 mRNA transport RNA processing and splicing 1.46E-02 GO:0044773 mitotic DNA damage checkpoint cell cycle regulation; DNA damage checkpoint 1.47E-02 GO:0071897 DNA biosynthetic process DNA biosynthesis 1.49E-02 GO:2001242 regulation of intrinsic apoptotic signaling pathway apoptotic signaling 1.52E-02 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway TGFB signaling 1.56E-02 GO:0014855 striated muscle cell proliferation heart development 1.67E-02 GO:0007517 muscle organ development heart development 1.68E-02 REAC:109581 Apoptosis apoptotic signaling 1.72E-02 GO:0045137 development of primary sexual characteristics organ development 1.73E-02 GO:2000278 regulation of DNA biosynthetic process DNA biosynthesis 1.74E-02 GO:0035066 positive regulation of histone acetylation histone modification 1.77E-02 REAC:2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer Notch signaling 1.82E-02 REAC:2644603 Signaling by NOTCH1 in Cancer Notch signaling 1.82E-02 REAC:2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants Notch signaling 1.82E-02 REAC:2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Notch signaling 1.82E-02 REAC:2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch signaling 1.82E-02 GO:0001714 endodermal cell fate specification cell fate 1.89E-02 REAC:5357801 Programmed Cell Death apoptotic signaling 1.95E-02 GO:1902275 regulation of chromatin organization histone modification 1.95E-02 GO:0007411 axon guidance signal transduction 2.04E-02 REAC:2871796 FCERI mediated MAPK activation signal transduction 2.04E-02 GO:2000758 positive regulation of peptidyl-lysine acetylation histone modification 2.04E-02 GO:0048713 regulation of oligodendrocyte differentiation nervous system development 2.04E-02 GO:0003203 endocardial cushion morphogenesis organ development 2.04E-02 GO:0048593 camera-type eye morphogenesis eye development 2.06E-02 GO:1903533 regulation of protein targeting protein localization to nucleus 2.13E-02 GO:1901983 regulation of protein acetylation histone modification 2.14E-02 GO:0048708 astrocyte differentiation organ development 2.14E-02 GO:0044774 mitotic DNA integrity checkpoint cell cycle regulation; DNA damage checkpoint 2.17E-02 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process proteasomal protein catabolism 2.17E-02 GO:0097485 neuron projection guidance signal transduction 2.18E-02 GO:0007519 skeletal muscle tissue development heart development 2.20E-02 GO:0048645 animal organ formation organ development 2.21E-02 GO:0031334 positive regulation of protein complex assembly protein compex assembly 2.25E-02 GO:0043254 regulation of protein complex assembly protein compex assembly 2.26E-02 GO:0072009 nephron epithelium development organ development 2.29E-02 GO:0060411 cardiac septum morphogenesis organ development 2.40E-02 GO:0060675 ureteric bud morphogenesis organ development 2.50E-02 GO:2000615 regulation of histone H3-K9 acetylation histone modification 2.51E-02 GO:0048715 negative regulation of oligodendrocyte differentiation nervous system development 2.51E-02 REAC:114604 GPVI-mediated activation cascade hemopoiesis 2.54E-02 GO:0018107 peptidyl-threonine phosphorylation serine phosphorylation 2.55E-02 GO:0050679 positive regulation of epithelial cell proliferation epithelial cell proliferation 2.58E-02 REAC:2219528 PI3K/AKT Signaling in Cancer signal transduction 2.58E-02 GO:0003281 ventricular septum development organ development 2.60E-02 REAC:6804758 Regulation of TP53 Activity through Acetylation cell cycle regulation; DNA damage checkpoint 2.61E-02 GO:0071156 regulation of cell cycle arrest cell cycle regulation; DNA damage checkpoint 2.68E-02 GO:1901796 regulation of signal transduction by p53 class mediator cell cycle regulation; DNA damage checkpoint 2.68E-02 GO:0072171 mesonephric tubule morphogenesis organ development 2.70E-02 GO:0071479 cellular response to ionizing radiation radiation response 2.70E-02 GO:0006353 "DNA-templated transcription, termination" RNA processing and splicing 2.79E-02 GO:0060538 skeletal muscle organ development heart development 2.90E-02 GO:1903708 positive regulation of hemopoiesis hemopoiesis 2.90E-02 GO:0050852 T cell receptor signaling pathway signal transduction 3.01E-02 GO:0006406 mRNA export from nucleus RNA processing and splicing 3.27E-02 GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus RNA processing and splicing 3.27E-02 GO:0003143 embryonic heart tube morphogenesis organ development 3.28E-02 GO:0071241 cellular response to inorganic substance response to metal ion 3.37E-02 CORUM:3063 Brg1-associated complex II chromatin remodeling 3.38E-02 GO:0045792 negative regulation of cell size cell migration 3.44E-02 GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway apoptotic signaling 3.47E-02 GO:1901985 positive regulation of protein acetylation histone modification 3.47E-02 GO:0035909 aorta morphogenesis organ development 3.49E-02 GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process proteasomal protein catabolism 3.50E-02 GO:0010038 response to metal ion response to metal ion 3.56E-02 GO:0030324 lung development organ development 3.63E-02 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway androgen receptor signaling 3.89E-02 GO:0007179 transforming growth factor beta receptor signaling pathway TGFB signaling 3.93E-02 REAC:171007 p38MAPK events signal transduction 3.94E-02 REAC:198323 AKT phosphorylates targets in the cytosol signal transduction 3.94E-02 GO:0022409 positive regulation of cell-cell adhesion hemopoiesis 4.00E-02 REAC:448424 Interleukin-17 signaling signal transduction 4.10E-02 REAC:4641265 Repression of WNT target genes Wnt signaling 4.10E-02 REAC:1226099 Signaling by FGFR in disease signal transduction 4.11E-02 GO:0008637 apoptotic mitochondrial changes protein localization to membrane 4.19E-02 GO:0030323 respiratory tube development organ development 4.20E-02 GO:0051403 stress-activated MAPK cascade kinase signaling 4.24E-02 GO:0051204 protein insertion into mitochondrial membrane apoptotic signaling 4.41E-02 GO:1905898 positive regulation of response to endoplasmic reticulum stress apoptotic signaling 4.41E-02 GO:1904031 positive regulation of cyclin-dependent protein kinase activity cell cycle regulation; DNA damage checkpoint 4.41E-02 GO:0007257 activation of JUN kinase activity kinase signaling 4.41E-02 GO:0043970 histone H3-K9 acetylation histone modification 4.57E-02 GO:0060742 epithelial cell differentiation involved in prostate gland development organ development 4.57E-02 GO:0003206 cardiac chamber morphogenesis organ development 4.65E-02 GO:0031123 RNA 3'-end processing RNA processing and splicing 4.65E-02 GO:0045765 regulation of angiogenesis cell migration 4.66E-02 GO:0072078 nephron tubule morphogenesis organ development 4.78E-02 GO:0061102 stomach neuroendocrine cell differentiation organ development 4.84E-02 GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition Wnt signaling 4.84E-02 REAC:6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest cell cycle regulation; DNA damage checkpoint 4.99E-02 CORUM:6073 SRp30c-SRp55 complex RNA processing and splicing 5.00E-02 REAC:350054 "Notch-HLH transcription pathway " Notch signaling #N/A GO:0042493 "response to drug " response to carbohydrate #N/A