{"text_format":"3","workbook":"xls","n_sheets":7,"sheets":["Fig. 3e","Fig. 4b","Fig. 4h","Supplementary figure. 1b","Supplementary figure. 6a","Supplementary figure. 7a","statistical analysis"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Fig. 3e","index":0,"n_rows":18,"n_cols":5,"rows_kept":18,"merged":[[0,0,0,4]],"flags":["formulas_cached_only"]}
["Fig.3e Body size for wild-type embryos, Mash2mat-ko/pat-wt embryos, Peg10mat-wt/pat-ko embryos, Mash2mat-wt/pat-ko embryos and Peg10mat-ko/pat-wt embryos"]
["Mash2 M-ko/P-wt","Peg10 P-ko/M-wt","Mash2 P-ko/M-wt","Peg10 M-ko/P-wt","Wild-type"]
[0.56,{"v":0.5,"d":"0.50"},1.23,1.11,{"v":1,"d":"1.00"}]
[0.31,0.31,1.13,1.05,1.02]
[0.83,0.25,1.06,1.04,0.85]
[0.81,0.96,0.98,0.92,1.04]
[{"v":0.9,"d":"0.90"},0.49,0.97,0.97,1.07]
[{"v":0.6,"d":"0.60"},0.61,0.99,0.95,1.18]
[null,0.61,0.95,null,0.84]
[null,0.85,null,null,0.55]
[null,0.78,null,null,0.98]
[null,0.77,null,null,1.13]
[null,0.83,null,null,1.11]
[null,{"v":0.9,"d":"0.90"},null,null,{"v":1.1,"d":"1.10"}]
[null,0.72,null,null,1.06]
[{"$nulls":4},1.07]
[{"$nulls":4},1.29]
[{"$nulls":4},0.88]

{"sheet":"Fig. 4b","index":1,"n_rows":4,"n_cols":4,"rows_kept":4,"flags":["formulas_cached_only"]}
["Fig.4b Percentage of induced mutation types in exon 4 of Fgfr3 by Past-CRISPR for each of two sgRNAs."]
[null,"Mono-allelic mutations","Wild-type","Mosaic mutations"]
["Fgfr3-sgRNA1","15(79%)","2(10.5%)","1(10.5%)"]
["Fgfr3-sgRNA2","1(4.8%)","20(95.2%)","0(0%)"]

{"sheet":"Fig. 4h","index":2,"n_rows":32,"n_cols":4,"rows_kept":32,"flags":["formulas_cached_only"]}
["Fig.4h"]
["BMD","Wild-type","G369C del/+","G369C/+"]
[null,817.4756,819.39,893.154]
[null,836.757,848.752,819.943]
[null,809.753,810.125,864.995]
[null,828.898,838.498,864.368]
[null,815.179,828.804,818.325]
[null,819.68,814.176,848.88]
[]
["BV/TV","Wild-type","G369C del/+","G369C/+"]
[null,0.2257,0.1467,0.0921]
[null,0.2188,0.199,0.053]
[null,0.1625,0.1978,0.0782]
[null,0.2382,0.1634,0.0594]
[null,0.1607,0.2376,0.0677]
[null,0.1925,0.2471,0.1122]
[]
["Tb.N","Wild-type","G369C del/+","G369C/+"]
[null,5.3392,5.393,3.1771]
[null,5.3616,5.2994,3.2846]
[null,5.409,5.2313,3.283]
[null,5.2717,5.3932,3.4804]
[null,5.3676,5.2096,3.0157]
[null,5.0456,5.0367,3.1437]
[]
["Tb.Sp","Wild-type","G369C del/+","G369C/+"]
[null,0.1854,0.1812,0.3192]
[null,0.1778,0.1751,0.3134]
[null,0.1817,0.1798,0.3145]
[null,0.1763,0.1849,0.3147]
[null,0.1789,0.1859,0.3172]
[null,0.1869,0.1877,0.323]

{"sheet":"Supplementary figure. 1b","index":3,"n_rows":6,"n_cols":13,"rows_kept":6,"merged":[[0,0,0,12],[1,1,1,3],[1,4,1,6],[1,7,1,9],[1,10,1,12],[8,0,8,6]],"flags":["formulas_cached_only"]}
["Supplementary figure 1b. The number of embryos counted in stages of each group "]
[null,"Anapc2 ko embryos",null,null,"Anapc2 Mat-ko embryos",null,null,"Anapc2 Pat-ko embryos",null,null,"Wild-type emrbyos"]
["2-cell",39,33,41,33,35,28,32,34,24,56,47,63]
["4-cell",38,32,39,32,34,27,31,33,23,55,47,61]
["morula",37,29,36,31,32,26,30,31,22,54,45,57]
["blastocyst",2,1,3,26,30,22,25,28,20,50,43,53]

{"sheet":"Supplementary figure. 6a","index":4,"n_rows":3,"n_cols":8,"rows_kept":3,"merged":[[0,0,0,6],[1,2,1,3],[1,4,1,5],[1,6,1,7],[2,0,2,1]],"flags":["formulas_cached_only"]}
["Supplementary figure. 6a"]
[null,null,"wild-type",null,"Mash2 KO",null,"Peg10 KO"]
["percentage of blastocysts n/(%)",null,"14(93.3%)","23(88.5%)","11(84.6%)","12(92%)","12(85.7%)","23(92%)"]

{"sheet":"Supplementary figure. 7a","index":5,"n_rows":3,"n_cols":11,"rows_kept":3,"merged":[[0,0,0,6],[1,2,1,3],[1,4,1,5],[1,6,1,7],[1,8,1,9],[1,10,1,11],[2,2,2,3],[2,4,2,5],[2,6,2,7],[2,8,2,9],[2,10,2,11]],"flags":["formulas_cached_only"]}
["Supplementary figure. 7a"]
[null,null,"Mash2 mat-ko/pat-wt",null,"Mash2 pat-ko/mat-wt",null,"Peg10 mat-ko/pat-wt",null,"Peg10 pat-ko/mat-wt",null,"wild-type"]
["percentage of blastocysts n/(%)",null,"25(83.3%)",null,"32(82.1%)",null,"32(82.1%)",null,"23(82.2%)",null,"40(90.9%)"]

{"sheet":"statistical analysis","index":6,"n_rows":21,"n_cols":14,"rows_kept":21,"merged":[[0,0,0,13],[1,0,2,0],[1,1,1,6],[1,7,1,13],[3,0,5,0],[6,0,8,0],[9,0,11,0],[12,0,14,0],[15,0,17,0],[18,0,20,0]],"flags":["formulas_cached_only"]}
["Supplementary Table 5. Summary of statistical analysis performed by one-way ANOVA"]
["Groups","Integral ANOVA results",{"$nulls":5},"Multiple comparison"]
[null,"ANOVA table","SS","DF","MS","F (DFn, DFd)","P value","Tukey's multiple comparisons test","Mean Diff.","95.00% CI of diff.","Significant?","Summary","Adjusted P Value"]
[" BMD analysis on femurs between Wildtype, G369C del/+ and G369C /+ groups (Fig.4h)","Treatment (between columns)",3144,2,1572,"F (2, 15) = 4.076","P=0.0386","Wildtype vs. G369C del/+",-5.334,"-34.79 to 24.12","No","ns",0.8861,"A-B"]
[null,"Residual (within columns)",5786,15,385.7,null,null,"Wildtype vs. G369C /+",-30.32,"-59.77 to -0.8682","Yes","*",0.0432,"A-C"]
[null,"Total",8930,17,{"$nulls":3},"G369C del/+ vs. G369C /+",-24.99,"-54.44 to 4.465","No","ns",0.103,"B-C"]
[" BV/TV analysis on femurs between Wildtype, G369C del/+ and G369C /+ groups (Fig.4h)","Treatment (between columns)",0.0596,2,0.0298,"F (2, 15) = 28.42","P<0.0001","Wildtype vs. G369C del/+",0.001133,"-0.04743 to 0.04969","No","ns",0.998,"A-B"]
[null,"Residual (within columns)",0.01573,15,0.001048,null,null,"Wildtype vs. G369C /+",0.1226,"0.07407 to 0.1712","Yes","****","<0.0001","A-C"]
[null,"Total",0.07533,17,{"$nulls":3},"G369C del/+ vs. G369C /+",0.1215,"0.07294 to 0.1701","Yes","****","<0.0001","B-C"]
[" TB.N analysis on femurs between Wildtype, G369C del/+ and G369C /+ groups (Fig.4h)","Treatment (between columns)",16.8,2,8.4,"F (2, 15) = 417.0","P<0.0001","Wildtype vs. G369C del/+",0.03858,"-0.1743 to 0.2514","No","ns",0.8859,"A-B"]
[null,"Residual (within columns)",0.3022,15,0.02014,null,null,"Wildtype vs. G369C /+",2.068,"1.856 to 2.281","Yes","****","<0.0001","A-C"]
[null,"Total",17.1,17,{"$nulls":3},"G369C del/+ vs. G369C /+",2.03,"1.817 to 2.243","Yes","****","<0.0001","B-C"]
[" TB.Sp analysis on femurs between Wildtype, G369C del/+ and G369C /+ groups (Fig.4h)","Treatment (between columns)",0.07312,2,0.03656,"F (2, 15) = 2072","P<0.0001","Wildtype vs. G369C del/+",-0.001267,"-0.007566 to 0.005033","No","ns",0.8617,"A-B"]
[null,"Residual (within columns)",0.0002647,15,1.765e-05,null,null,"Wildtype vs. G369C /+",-0.1358,"-0.1421 to -0.1295","Yes","****","<0.0001","A-C"]
[null,"Total",0.07339,17,{"$nulls":3},"G369C del/+ vs. G369C /+",-0.1346,"-0.1409 to -0.1283","Yes","****","<0.0001","B-C"]
["analysis on bodysize between Mash2m-/p+, Mash2m+/p- and wild-type (Fig.3e)","Treatment (between columns)",0.5964,2,0.2982,"F (2, 26) = 10.44","P=0.0005","Mash2 M-ko/P-wt vs. Mash2 M-wt/P-ko",-0.376,"-0.6096 to -0.1423","Yes","**",0.0013,"A-B"]
[null,"Residual (within columns)",0.7428,26,0.02857,null,null,"Mash2 M-ko/P-wt vs. wt",-0.342,"-0.5431 to -0.1410","Yes","***",0.0007,"A-C"]
[null,"Total",1.339,28,{"$nulls":3},"Mash2 M-wt/P-ko vs. wt",0.03391,"-0.1564 to 0.2242","No","ns",0.898,"B-C"]
["analysis on bodysize between Peg10m-/p+, Peg10m+/p- and wild-type (Fig.3e)","Treatment (between columns)",0.9974,2,0.4987,"F (2, 32) = 15.15","P<0.0001","Peg10 M-wt/P-ko vs. Peg10 M-ko/P-wt",-0.3467,"-0.5667 to -0.1266","Yes","**",0.0014,"A-B"]
[null,"Residual (within columns)",1.053,32,0.03291,null,null,"Peg10 M-wt/P-ko vs. wt",-0.3504,"-0.5168 to -0.1839","Yes","****","<0.0001","A-C"]
[null,"Total",2.051,34,{"$nulls":3},"Peg10 M-ko/P-wt vs. wt",-0.003708,"-0.2171 to 0.2097","No","ns",0.999,"B-C"]