{"text_format":"3","workbook":"xls","n_sheets":3,"sheets":["Supplemental Data 2 Legend","formatted","rfClass_dmlDmgData_df"],"not_rendered":{"external_links":1},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Supplemental Data 2 Legend","index":0,"n_rows":1,"n_cols":1,"rows_kept":1,"flags":["formulas_cached_only"]}
["Supplemental Data 2. Union of top 10% most important differentially methylated loci (DML) selected by random forest models that separate anti-CCP3(-), At-Risk, and Early RA samples. After feature selection, the models achieved accuracies of 89.7%, 78.1% and 96.8% on the test data when discriminating between Early RA vs At-Risk, Early RA vs anti-CCP3(-) Controls and At-Risk vs anti-CCP3(-) Controls, respectively. A differentially methylated gene (DMG) is listed if a DML is identified in the gene’s promoter region or gene body. Source data are provided as a Source Data file."]

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[null,"Δβ (q value) "]
["DML","ACPA+ vs. ACPA-","ACPA- vs. ERA","ACPA+ vs. ERA","DMG(s)"]
["cg02063695","0.00 (9.30E-01)","0.06 (1.82E-05)","0.06 (6.71E-05)",""]
["cg05084668","0.01 (7.96E-01)","-0.09 (1.01E-04)","-0.09 (6.62E-04)","ALG1L"]
["cg23159337","0.00 (8.92E-01)","-0.04 (2.23E-03)","-0.04 (1.45E-03)",""]
["cg14137381","-0.02 (1.43E-01)","0.08 (3.22E-05)","0.06 (1.83E-03)",""]
["cg22025206","-0.02 (8.32E-02)","0.08 (7.17E-07)","0.06 (7.79E-05)",""]
["cg11629812","-0.02 (5.17E-02)","-0.02 (1.02E-01)","-0.04 (1.02E-03)",""]
["cg05283184","0.04 (1.09E-03)","0.02 (2.21E-01)","0.06 (1.51E-04)","IRAK1BP1"]
["cg05076221","0.00 (7.79E-01)","0.05 (1.71E-05)","0.05 (7.32E-05)","HOXA5"]
["cg09207400","0.00 (7.00E-01)","0.05 (7.28E-06)","0.04 (3.87E-05)","HOXA5"]
["cg14014955","-0.01 (4.85E-01)","0.05 (7.28E-06)","0.04 (1.48E-04)","HOXA5"]
["cg17432857","0.00 (9.51E-01)","0.05 (7.21E-06)","0.05 (1.24E-05)","HOXA3"]
["cg27151303","0.00 (9.93E-01)","0.05 (1.10E-05)","0.05 (2.28E-05)","HOXA3"]
["cg20478239","0.00 (9.03E-01)","0.07 (1.15E-05)","0.07 (7.99E-06)",""]
["cg15123087","0.00 (9.80E-01)","-0.08 (8.87E-06)","-0.08 (5.78E-07)","ARHGEF5"]
["cg06106484","0.03 (4.49E-02)","0.02 (2.85E-01)","0.05 (5.11E-03)",""]
["cg25009553","-0.03 (3.24E-01)","-0.06 (3.55E-02)","-0.09 (2.13E-03)",""]
["cg13789015","-0.02 (6.99E-02)","-0.03 (5.60E-02)","-0.05 (1.12E-03)",""]
["cg16653991","0.00 (9.52E-01)","-0.03 (1.57E-01)","-0.03 (1.78E-01)",""]
["cg21224286","0.00 (9.53E-01)","-0.05 (2.87E-03)","-0.05 (2.99E-03)","CACNA2D4"]
["cg04453367","0.00 (8.56E-01)","0.04 (8.38E-04)","0.04 (1.50E-03)","CHGA"]
["cg09971646","0.02 (6.75E-02)","0.02 (3.94E-02)","0.05 (8.20E-05)",""]
["cg10838389","0.01 (1.17E-01)","0.02 (1.91E-02)","0.03 (1.51E-04)",""]
["cg26963367","0.00 (9.05E-01)","0.05 (5.34E-04)","0.05 (2.64E-04)",""]
["cg10332116","0.01 (5.22E-01)","0.05 (1.38E-04)","0.05 (9.27E-05)",""]
["cg20008800","0.00 (9.05E-01)","-0.05 (4.44E-03)","-0.04 (1.04E-02)",""]
["cg03049249","-0.01 (3.89E-01)","0.07 (1.60E-05)","0.06 (2.63E-04)","RP11-219A15.1"]
["cg04657146","0.07 (8.87E-02)","0.13 (2.54E-04)","0.20 (5.73E-07)",""]
["cg23899408","0.05 (8.32E-02)","0.11 (1.35E-04)","0.16 (3.30E-07)","HOOK2"]
["cg20381372","-0.06 (2.01E-01)","-0.13 (1.69E-03)","-0.19 (3.87E-05)",""]
["cg25925710","-0.01 (8.79E-01)","0.09 (1.35E-03)","0.09 (2.62E-03)",""]
["cg17782550","0.00 (9.05E-01)","-0.04 (1.01E-03)","-0.04 (1.79E-03)",""]
["cg08477332","-0.02 (6.89E-01)","-0.13 (4.05E-04)","-0.14 (1.20E-04)",""]
["cg06494592","0.02 (3.62E-01)","0.07 (7.28E-06)","0.09 (1.85E-08)",""]
["cg04553112","0.02 (1.71E-01)","0.07 (8.87E-06)","0.10 (8.87E-09)",""]
["cg17250082","0.05 (1.63E-02)","0.04 (1.27E-02)","0.09 (2.28E-05)",""]
["cg08762424","0.05 (6.50E-02)","0.05 (1.92E-02)","0.10 (1.94E-04)",""]
["cg19432846","0.04 (7.43E-02)","0.06 (3.93E-04)","0.10 (2.26E-07)",""]
["cg17975832","-0.02 (3.99E-01)","-0.05 (2.35E-02)","-0.07 (2.51E-03)",""]
["cg26913058","0.01 (5.25E-01)","0.10 (9.62E-04)","0.11 (2.64E-04)","MRPL28"]
["cg12437481","0.01 (5.22E-01)","0.08 (1.27E-03)","0.09 (2.64E-04)","MRPL28"]
["cg02219949","0.01 (5.78E-01)","0.06 (1.88E-03)","0.07 (4.31E-04)",""]
["cg08835041","0.02 (3.15E-01)","0.10 (1.30E-03)","0.12 (1.90E-04)",""]
["cg10044179","0.01 (7.00E-01)","0.08 (5.98E-04)","0.10 (1.94E-04)",""]
["cg17519938","0.02 (3.31E-02)","0.01 (3.39E-01)","0.03 (7.89E-03)",""]
["cg03306615","0.01 (2.01E-01)","0.03 (1.21E-02)","0.05 (1.02E-03)",""]
["cg26051413","0.02 (7.11E-02)","0.03 (8.90E-02)","0.05 (4.36E-03)",""]
["cg15971518","0.01 (5.77E-01)","0.07 (3.68E-03)","0.08 (6.62E-04)",""]
["cg27630820","-0.02 (3.92E-01)","0.05 (2.45E-03)","0.03 (3.52E-02)","PIWIL1"]
["cg19424457","-0.02 (3.24E-01)","0.06 (9.01E-04)","0.04 (1.89E-02)","PIWIL1"]
["cg11931211","-0.03 (2.75E-01)","0.05 (1.85E-02)","0.02 (2.43E-01)","PIWIL1"]
["cg26168643","0.04 (1.15E-02)","0.00 (9.50E-01)","0.04 (3.59E-02)",""]
["cg15111296","0.02 (5.63E-01)","0.07 (1.73E-03)","0.08 (1.90E-04)",""]
["cg12892701","0.00 (9.46E-01)","0.07 (2.29E-04)","0.07 (1.94E-04)","HOPX"]
["cg04364695","0.02 (1.41E-01)","0.06 (1.80E-03)","0.08 (3.87E-05)","ZMAT4"]
["cg00817464","-0.01 (8.57E-01)","0.15 (3.45E-05)","0.14 (1.24E-04)","XPNPEP1"]
["cg22190077","-0.01 (6.89E-01)","-0.06 (1.91E-02)","-0.07 (5.58E-03)",""]
["cg04244433","0.00 (9.06E-01)","-0.07 (9.41E-04)","-0.07 (1.83E-03)","GTF3A"]
["cg11655627","0.00 (9.05E-01)","-0.07 (4.36E-04)","-0.07 (1.02E-03)","GTF3A"]
["cg04413036","0.04 (1.20E-01)","0.04 (4.08E-02)","0.08 (2.62E-04)",""]
["cg05690441","0.00 (7.85E-01)","0.03 (1.34E-03)","0.04 (5.53E-04)","CYR61"]
["cg18822299","-0.01 (7.86E-01)","0.08 (7.62E-04)","0.07 (1.99E-03)","DDX10"]
["cg13861644","-0.02 (2.84E-01)","0.06 (2.08E-03)","0.03 (4.63E-02)","PIWIL1"]
["cg15011409","0.01 (1.17E-01)","0.02 (1.20E-01)","0.03 (8.18E-03)",""]
["cg13546858","-0.02 (3.46E-01)","-0.01 (4.11E-01)","-0.03 (5.47E-02)",""]
["cg02769477","0.00 (9.92E-01)","0.06 (3.79E-03)","0.06 (3.95E-03)",""]
["cg10417901","0.02 (5.05E-02)","-0.05 (7.21E-06)","-0.03 (2.99E-03)",""]
["cg07929412","-0.08 (1.15E-02)","0.08 (7.29E-03)","0.00 (9.39E-01)",""]
["cg24229304","0.01 (7.85E-01)","-0.06 (1.56E-03)","-0.05 (5.58E-03)",""]
["cg11045331","-0.02 (3.09E-02)","0.02 (2.68E-02)","0.00 (8.86E-01)",""]
["cg02691506","0.01 (6.63E-01)","0.09 (7.21E-06)","0.10 (6.09E-07)","SSUH2"]
["cg18697348","-0.02 (1.20E-01)","0.04 (1.10E-03)","0.02 (8.95E-02)","SELK"]
["cg15204487","0.00 (9.16E-01)","-0.06 (1.27E-03)","-0.05 (1.43E-03)",""]
["cg03209412","0.02 (2.44E-01)","-0.04 (3.02E-03)","-0.03 (4.24E-02)",""]
["cg26968378","-0.02 (1.17E-01)","0.04 (4.42E-03)","0.02 (1.85E-01)",""]
["cg12633154","0.02 (4.94E-01)","0.11 (8.87E-06)","0.13 (3.30E-07)","RNF39"]
["cg14600855","0.00 (8.32E-01)","0.04 (4.22E-03)","0.04 (2.99E-03)","CLIC5"]
["cg27352433","-0.01 (5.19E-01)","0.06 (3.58E-05)","0.05 (4.31E-04)",""]
["cg22852245","-0.02 (4.88E-01)","0.09 (3.68E-03)","0.07 (3.00E-02)","MCM9"]
["cg13808314","-0.03 (7.84E-02)","0.06 (6.87E-05)","0.03 (3.19E-02)","THSD7A"]
["cg17569124","-0.01 (4.94E-01)","0.06 (4.69E-06)","0.05 (6.00E-05)","HOXA3"]
["cg02005600","-0.01 (3.15E-01)","0.06 (4.69E-06)","0.05 (1.20E-04)","HOXA3"]
["cg14882265","-0.01 (5.63E-01)","0.05 (3.82E-05)","0.04 (3.68E-04)",""]
["cg20234172","0.02 (1.05E-01)","-0.05 (2.64E-05)","-0.03 (5.92E-03)",""]
["cg25601471","-0.03 (4.49E-02)","0.07 (7.57E-05)","0.04 (2.65E-02)",""]
["cg27134251","-0.03 (4.49E-02)","0.07 (7.63E-05)","0.04 (2.12E-02)",""]
["cg09050832","-0.04 (4.65E-02)","0.08 (1.16E-04)","0.04 (3.38E-02)",""]
["cg02490460","-0.03 (6.47E-02)","0.08 (6.87E-05)","0.05 (1.37E-02)",""]
["cg01003893","0.02 (3.11E-01)","-0.02 (1.79E-01)","0.00 (8.60E-01)",""]
["cg04579291","-0.02 (2.75E-02)","0.07 (7.28E-06)","0.05 (1.06E-03)","SLC25A37"]
["cg25569470","-0.01 (3.45E-01)","0.05 (2.64E-05)","0.04 (6.78E-04)",""]
["cg09365932","-0.02 (3.26E-01)","0.08 (1.43E-04)","0.06 (3.72E-03)",""]
["cg06894600","-0.01 (3.99E-01)","0.05 (1.95E-05)","0.04 (4.49E-04)",""]
["cg16352527","-0.02 (1.48E-02)","0.04 (1.71E-05)","0.03 (7.59E-03)",""]
["cg02786339","-0.01 (3.24E-01)","0.02 (2.30E-03)","0.02 (4.13E-02)",""]
["cg15480998","-0.01 (1.71E-01)","0.04 (7.21E-06)","0.03 (7.55E-04)","KCNMA1"]
["cg17686260","0.06 (4.49E-02)","-0.12 (7.21E-06)","-0.06 (7.62E-03)",""]
["cg12859507","0.00 (9.92E-01)","-0.07 (3.70E-03)","-0.07 (3.69E-03)",""]
["cg16481612","-0.02 (1.98E-01)","0.07 (2.94E-05)","0.05 (1.50E-03)",""]
["cg09296044","0.00 (9.33E-01)","0.04 (2.35E-02)","0.04 (3.24E-02)","EPB42"]
["cg03744383","-0.03 (1.43E-02)","0.07 (8.87E-06)","0.04 (1.37E-02)","CES1"]
["cg05457730","-0.01 (8.56E-01)","0.09 (9.50E-04)","0.08 (2.51E-03)",""]
["cg22798362","0.00 (9.63E-01)","-0.06 (1.09E-03)","-0.06 (1.45E-03)",""]
["cg21329660","0.01 (5.11E-01)","-0.06 (9.85E-05)","-0.05 (9.61E-04)",""]
["cg10783469","0.01 (4.41E-01)","0.03 (3.22E-04)","0.04 (1.58E-05)",""]
["cg03847896","-0.01 (6.70E-01)","0.10 (7.41E-05)","0.09 (5.09E-04)","RAP1A"]
["cg17218026","0.00 (8.40E-01)","-0.07 (5.56E-04)","-0.06 (1.27E-03)","ADAR"]
["cg19699106","0.09 (5.72E-04)","-0.11 (8.87E-06)","-0.02 (2.81E-01)",""]
["cg02077920","0.03 (1.20E-01)","-0.06 (1.27E-03)","-0.03 (6.84E-02)",""]
["cg18082583","-0.02 (3.24E-01)","0.07 (1.89E-03)","0.05 (3.29E-02)","TTC27"]
["cg09220401","0.04 (4.49E-02)","-0.11 (7.17E-07)","-0.07 (6.78E-04)",""]
["cg20053110","-0.06 (6.76E-02)","0.10 (6.33E-04)","0.04 (1.73E-01)",""]
["cg18434912","0.02 (4.85E-01)","-0.07 (1.82E-02)","-0.05 (9.93E-02)","AMD1"]
["cg11539674","-0.03 (4.49E-02)","0.07 (2.46E-05)","0.04 (1.96E-02)","SND1"]
["cg12183347","0.01 (7.35E-01)","-0.07 (5.86E-03)","-0.06 (1.45E-02)",""]
["cg14024893","0.00 (9.46E-01)","0.06 (3.12E-03)","0.06 (4.68E-03)","ENTPD2"]
["cg02275226","0.03 (3.89E-01)","-0.07 (2.08E-03)","-0.05 (3.84E-02)",""]
["cg18705301","0.06 (3.63E-02)","-0.10 (2.40E-05)","-0.04 (4.73E-02)",""]
["cg02301920","-0.01 (4.94E-01)","0.10 (2.64E-05)","0.09 (3.35E-04)","CES1"]
["cg04850148","0.08 (1.15E-02)","-0.17 (8.87E-06)","-0.09 (1.24E-02)","CCL4L1"]
["cg20246743","-0.02 (4.94E-01)","0.06 (1.27E-02)","0.04 (7.28E-02)",""]
["cg10148932","-0.03 (1.78E-01)","0.11 (2.26E-04)","0.08 (7.94E-03)",""]
["cg01243097","-0.03 (8.99E-02)","0.08 (1.14E-04)","0.05 (1.37E-02)",""]
["cg15242686","0.01 (7.73E-01)","-0.10 (3.58E-05)","-0.09 (2.64E-04)",""]
["cg11247378","-0.06 (5.17E-02)","0.14 (7.21E-06)","0.08 (3.56E-03)",""]
["cg01934408","-0.01 (4.85E-01)","-0.03 (5.97E-03)","-0.04 (6.62E-04)",""]
["cg25608392","0.00 (9.53E-01)","0.02 (1.81E-01)","0.02 (2.05E-01)",""]
["cg18467790","-0.13 (1.09E-03)","0.10 (1.54E-02)","-0.03 (5.08E-01)",""]
["cg12443985","-0.01 (5.97E-01)","0.04 (9.19E-03)","0.03 (3.37E-02)","TRAPPC9"]
["cg26626342","-0.01 (1.71E-01)","0.02 (1.48E-02)","0.01 (2.67E-01)","COL13A1"]
["cg18319102","-0.03 (7.65E-02)","0.04 (1.05E-02)","0.01 (3.83E-01)","PIWIL1"]
["cg18980028","0.01 (5.97E-01)","0.04 (1.92E-02)","0.05 (4.56E-03)",""]
["cg11142730","0.05 (3.89E-03)","-0.07 (2.54E-04)","-0.02 (2.67E-01)",""]
["cg01366882","0.03 (6.50E-02)","-0.07 (3.37E-06)","-0.05 (1.45E-03)","CDH4"]
["cg14087524","0.02 (5.96E-01)","0.09 (3.99E-03)","0.10 (1.02E-03)","INPP5B"]
["cg17797028","0.02 (2.99E-01)","-0.07 (9.01E-04)","-0.05 (1.62E-02)",""]
["cg17865545","0.04 (4.49E-02)","-0.10 (9.38E-07)","-0.06 (8.91E-04)",""]
["cg17013363","-0.02 (4.80E-02)","0.08 (8.87E-06)","0.06 (1.07E-03)",""]
["cg01829241","-0.04 (1.15E-02)","0.09 (8.87E-06)","0.05 (8.18E-03)",""]
["cg16426182","0.03 (3.58E-02)","-0.07 (2.40E-05)","-0.03 (1.97E-02)",""]
["cg04468621","-0.02 (6.47E-02)","0.07 (3.58E-05)","0.05 (2.18E-03)","RP11-701P16.2"]
["cg13005202","-0.03 (2.78E-02)","0.08 (2.33E-05)","0.05 (8.14E-03)",""]
["cg24796644","-0.05 (4.61E-02)","0.08 (3.95E-04)","0.03 (1.89E-01)",""]
["cg26872907","-0.02 (4.65E-02)","0.07 (4.56E-05)","0.05 (6.10E-03)",""]
["cg12590535","0.01 (5.96E-01)","-0.07 (4.36E-04)","-0.06 (2.33E-03)",""]
["cg15871419","0.02 (7.24E-02)","-0.08 (1.11E-04)","-0.06 (2.71E-03)",""]
["cg09507567","0.02 (2.69E-01)","-0.07 (2.96E-06)","-0.05 (6.14E-05)",""]
["cg06064525","-0.01 (7.00E-01)","0.05 (7.83E-03)","0.04 (3.24E-02)",""]
["cg12070987","-0.02 (6.76E-02)","0.07 (1.03E-05)","0.05 (1.55E-03)","TCIRG1"]
["cg08863777","-0.03 (1.14E-02)","0.07 (7.28E-06)","0.04 (4.56E-03)",""]
["cg10838410","-0.03 (3.31E-02)","0.09 (1.71E-05)","0.06 (3.69E-03)",""]
["cg16847214","0.02 (3.15E-01)","-0.09 (3.37E-06)","-0.07 (7.79E-05)",""]
["cg09711238","0.01 (5.63E-01)","-0.05 (1.94E-03)","-0.04 (1.19E-02)","IFNG"]
["cg00291442","0.02 (3.81E-01)","-0.05 (1.76E-03)","-0.04 (1.99E-02)","ANKS1B"]
["cg18105134","0.02 (5.63E-01)","0.10 (1.21E-03)","0.11 (1.90E-04)","PROZ"]
["cg16688050","0.03 (4.49E-02)","-0.07 (2.40E-05)","-0.04 (9.46E-03)",""]
["cg19649900","-0.02 (3.79E-02)","0.08 (7.28E-06)","0.05 (1.06E-03)",""]
["cg24399712","-0.04 (7.18E-02)","0.11 (4.69E-06)","0.07 (1.16E-03)",""]
["cg24920358","-0.02 (1.91E-01)","0.04 (1.19E-03)","0.02 (4.62E-02)","PPIE"]
["cg11518408","-0.02 (3.31E-02)","0.04 (7.96E-05)","0.02 (1.96E-02)",""]
["cg19759481","-0.01 (5.85E-01)","0.06 (9.44E-06)","0.06 (1.24E-04)","HOXA3"]
["cg25307665","-0.01 (4.94E-01)","0.07 (6.29E-05)","0.06 (7.36E-04)","HOXA3"]
["cg06758847","-0.02 (1.05E-01)","0.04 (1.68E-02)","0.01 (3.56E-01)",""]
["cg07040013","-0.02 (2.84E-01)","0.07 (3.48E-03)","0.05 (3.99E-02)",""]
["cg23596287","0.02 (1.74E-01)","-0.06 (2.36E-05)","-0.04 (2.01E-03)",""]
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