Analysis Type: PANTHER Overrepresentation Test (Released 20240226) Annotation Version and Release Date: GO Ontology database DOI: 10.5281/zenodo.10536401 Released 2024-01-17 Analyzed List: upload_1 (Homo sapiens) Reference List: Homo sapiens (all genes in database) Test Type: FISHER Correction: FDR GO biological process complete Homo sapiens - REFLIST (20592) upload_1 (158) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (raw P-value) upload_1 (FDR) positive regulation of chondrocyte development (GO:1902761) 2 2 0.02 + > 100 5.85E-05 7.62E-03 forebrain astrocyte development (GO:0021897) 3 2 0.02 + 86.89 1.75E-04 1.99E-02 forebrain astrocyte differentiation (GO:0021896) 3 2 0.02 + 86.89 1.75E-04 1.97E-02 globus pallidus development (GO:0021759) 4 2 0.03 + 65.16 3.47E-04 3.48E-02 club cell differentiation (GO:0060486) 4 2 0.03 + 65.16 3.47E-04 3.46E-02 type I pneumocyte differentiation (GO:0060509) 8 3 0.06 + 48.87 2.41E-05 3.54E-03 lung secretory cell differentiation (GO:0061140) 10 3 0.08 + 39.1 5.11E-05 6.90E-03 spinal cord motor neuron cell fate specification (GO:0021520) 11 3 0.08 + 35.54 6.99E-05 9.03E-03 embryonic skeletal joint morphogenesis (GO:0060272) 11 3 0.08 + 35.54 6.99E-05 8.95E-03 CRD-mediated mRNA stabilization (GO:0070934) 11 3 0.08 + 35.54 6.99E-05 8.88E-03 negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900152) 12 3 0.09 + 32.58 9.27E-05 1.12E-02 embryonic skeletal joint development (GO:0072498) 15 3 0.12 + 26.07 1.88E-04 2.10E-02 positive regulation of cytoplasmic translation (GO:2000767) 15 3 0.12 + 26.07 1.88E-04 2.08E-02 proximal/distal pattern formation (GO:0009954) 35 7 0.27 + 26.07 7.69E-09 1.58E-06 lung epithelial cell differentiation (GO:0060487) 26 5 0.2 + 25.06 1.44E-06 2.58E-04 lung cell differentiation (GO:0060479) 26 5 0.2 + 25.06 1.44E-06 2.55E-04 definitive hemopoiesis (GO:0060216) 19 3 0.15 + 20.58 3.92E-04 3.86E-02 regulation of Rac protein signal transduction (GO:0035020) 26 4 0.2 + 20.05 4.37E-05 6.17E-03 dorsal spinal cord development (GO:0021516) 20 3 0.15 + 19.55 4.59E-04 4.40E-02 response to salt (GO:1902074) 20 3 0.15 + 19.55 4.59E-04 4.37E-02 positive regulation of chondrocyte differentiation (GO:0032332) 20 3 0.15 + 19.55 4.59E-04 4.35E-02 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151) 27 4 0.21 + 19.31 5.10E-05 7.01E-03 cell proliferation in forebrain (GO:0021846) 27 4 0.21 + 19.31 5.10E-05 6.94E-03 neuron fate specification (GO:0048665) 34 5 0.26 + 19.17 5.80E-06 9.94E-04 embryonic skeletal system morphogenesis (GO:0048704) 94 13 0.72 + 18.02 3.42E-13 1.68E-10 embryonic skeletal system development (GO:0048706) 129 17 0.99 + 17.18 1.56E-16 1.70E-13 lung epithelium development (GO:0060428) 39 5 0.3 + 16.71 1.16E-05 1.85E-03 pituitary gland development (GO:0021983) 43 5 0.33 + 15.15 1.90E-05 2.84E-03 negative regulation of epithelial to mesenchymal transition (GO:0010719) 35 4 0.27 + 14.89 1.45E-04 1.68E-02 neuron fate commitment (GO:0048663) 72 8 0.55 + 14.48 7.94E-08 1.55E-05 anterior/posterior pattern specification (GO:0009952) 220 22 1.69 + 13.03 1.87E-18 5.70E-15 forelimb morphogenesis (GO:0035136) 41 4 0.31 + 12.72 2.71E-04 2.79E-02 cell fate specification (GO:0001708) 88 8 0.68 + 11.85 3.84E-07 7.14E-05 neural nucleus development (GO:0048857) 70 6 0.54 + 11.17 1.62E-05 2.45E-03 forebrain cell migration (GO:0021885) 64 5 0.49 + 10.18 1.32E-04 1.54E-02 diencephalon development (GO:0021536) 81 6 0.62 + 9.65 3.75E-05 5.39E-03 skeletal system morphogenesis (GO:0048705) 232 17 1.78 + 9.55 2.84E-12 9.83E-10 spinal cord development (GO:0021510) 98 7 0.75 + 9.31 1.06E-05 1.73E-03 dorsal/ventral pattern formation (GO:0009953) 85 6 0.65 + 9.2 4.92E-05 6.82E-03 regulation of cartilage development (GO:0061035) 72 5 0.55 + 9.05 2.31E-04 2.48E-02 stem cell proliferation (GO:0072089) 73 5 0.56 + 8.93 2.46E-04 2.62E-02 negative regulation of neuron differentiation (GO:0045665) 74 5 0.57 + 8.81 2.62E-04 2.74E-02 regionalization (GO:0003002) 415 28 3.18 + 8.79 1.15E-18 5.85E-15 limbic system development (GO:0021761) 126 8 0.97 + 8.27 5.87E-06 9.95E-04 hippocampus development (GO:0021766) 95 6 0.73 + 8.23 9.18E-05 1.12E-02 pattern specification process (GO:0007389) 463 29 3.55 + 8.16 1.96E-18 4.98E-15 cerebral cortex development (GO:0021987) 130 8 1 + 8.02 7.40E-06 1.24E-03 neural precursor cell proliferation (GO:0061351) 106 6 0.81 + 7.38 1.68E-04 1.93E-02 neuron migration (GO:0001764) 142 8 1.09 + 7.34 1.41E-05 2.18E-03 embryonic limb morphogenesis (GO:0030326) 125 7 0.96 + 7.3 5.12E-05 6.85E-03 embryonic appendage morphogenesis (GO:0035113) 125 7 0.96 + 7.3 5.12E-05 6.79E-03 endocrine system development (GO:0035270) 132 7 1.01 + 6.91 7.24E-05 9.05E-03 embryonic organ morphogenesis (GO:0048562) 304 16 2.33 + 6.86 1.71E-09 3.84E-07 cell fate commitment (GO:0045165) 256 13 1.96 + 6.62 9.35E-08 1.80E-05 skeletal system development (GO:0001501) 507 24 3.89 + 6.17 1.01E-12 4.41E-10 negative regulation of translation (GO:0017148) 129 6 0.99 + 6.06 4.86E-04 4.57E-02 pallium development (GO:0021543) 194 9 1.49 + 6.05 1.95E-05 2.88E-03 embryonic organ development (GO:0048568) 460 21 3.53 + 5.95 5.87E-11 1.54E-08 limb morphogenesis (GO:0035108) 154 7 1.18 + 5.92 1.90E-04 2.08E-02 appendage morphogenesis (GO:0035107) 154 7 1.18 + 5.92 1.90E-04 2.06E-02 central nervous system neuron differentiation (GO:0021953) 179 8 1.37 + 5.82 7.41E-05 9.18E-03 hindbrain development (GO:0030902) 161 7 1.24 + 5.67 2.49E-04 2.64E-02 locomotory behavior (GO:0007626) 207 9 1.59 + 5.67 3.25E-05 4.71E-03 telencephalon development (GO:0021537) 278 12 2.13 + 5.63 1.66E-06 2.90E-04 lung development (GO:0030324) 189 8 1.45 + 5.52 1.08E-04 1.30E-02 chordate embryonic development (GO:0043009) 664 28 5.09 + 5.5 1.80E-13 9.46E-11 respiratory tube development (GO:0030323) 193 8 1.48 + 5.4 1.25E-04 1.48E-02 regulation of neuron differentiation (GO:0045664) 194 8 1.49 + 5.37 1.30E-04 1.52E-02 embryo development ending in birth or egg hatching (GO:0009792) 685 28 5.26 + 5.33 3.84E-13 1.83E-10 gland development (GO:0048732) 430 17 3.3 + 5.15 3.70E-08 7.42E-06 regulation of synaptic plasticity (GO:0048167) 203 8 1.56 + 5.14 1.77E-04 1.98E-02 cartilage development (GO:0051216) 178 7 1.37 + 5.13 4.57E-04 4.41E-02 forebrain development (GO:0030900) 413 16 3.17 + 5.05 1.26E-07 2.39E-05 respiratory system development (GO:0060541) 216 8 1.66 + 4.83 2.70E-04 2.80E-02 glial cell differentiation (GO:0010001) 218 8 1.67 + 4.78 2.87E-04 2.92E-02 gliogenesis (GO:0042063) 277 10 2.13 + 4.71 5.74E-05 7.55E-03 embryonic morphogenesis (GO:0048598) 596 21 4.57 + 4.59 6.23E-09 1.30E-06 negative regulation of transcription by RNA polymerase II (GO:0000122) 940 33 7.21 + 4.58 1.60E-13 8.70E-11 regulation of translation (GO:0006417) 379 13 2.91 + 4.47 7.56E-06 1.25E-03 embryo development (GO:0009790) 1059 35 8.13 + 4.31 1.50E-13 8.44E-11 brain development (GO:0007420) 742 24 5.69 + 4.22 2.50E-09 5.44E-07 learning or memory (GO:0007611) 280 9 2.15 + 4.19 3.21E-04 3.24E-02 animal organ morphogenesis (GO:0009887) 996 32 7.64 + 4.19 4.21E-12 1.37E-09 central nervous system development (GO:0007417) 1008 32 7.73 + 4.14 5.77E-12 1.80E-09 head development (GO:0060322) 792 25 6.08 + 4.11 1.84E-09 4.05E-07 positive regulation of transcription by RNA polymerase II (GO:0045944) 1265 39 9.71 + 4.02 4.18E-14 2.65E-11 negative regulation of cell differentiation (GO:0045596) 670 20 5.14 + 3.89 2.20E-07 4.14E-05 in utero embryonic development (GO:0001701) 405 12 3.11 + 3.86 7.10E-05 8.94E-03 regulation of amide metabolic process (GO:0034248) 443 13 3.4 + 3.82 3.89E-05 5.54E-03 negative regulation of DNA-templated transcription (GO:0045892) 1279 37 9.81 + 3.77 1.47E-12 5.91E-10 negative regulation of RNA biosynthetic process (GO:1902679) 1294 37 9.93 + 3.73 2.08E-12 7.94E-10 negative regulation of RNA metabolic process (GO:0051253) 1410 39 10.82 + 3.6 1.28E-12 5.28E-10 positive regulation of RNA metabolic process (GO:0051254) 1852 50 14.21 + 3.52 7.53E-16 5.46E-13 post-transcriptional regulation of gene expression (GO:0010608) 519 14 3.98 + 3.52 4.87E-05 6.81E-03 generation of neurons (GO:0048699) 1171 31 8.98 + 3.45 1.17E-09 2.75E-07 positive regulation of DNA-templated transcription (GO:0045893) 1711 45 13.13 + 3.43 8.57E-14 5.23E-11 positive regulation of RNA biosynthetic process (GO:1902680) 1714 45 13.15 + 3.42 9.12E-14 5.35E-11 regulation of neuron projection development (GO:0010975) 459 12 3.52 + 3.41 2.28E-04 2.47E-02 negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 1534 40 11.77 + 3.4 3.94E-12 1.31E-09 axon development (GO:0061564) 423 11 3.25 + 3.39 4.36E-04 4.26E-02 positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2059 53 15.8 + 3.35 5.50E-16 4.19E-13 neurogenesis (GO:0022008) 1346 34 10.33 + 3.29 5.35E-10 1.29E-07 negative regulation of developmental process (GO:0051093) 919 23 7.05 + 3.26 5.74E-07 1.05E-04 neuron differentiation (GO:0030182) 1095 27 8.4 + 3.21 7.04E-08 1.39E-05 cell population proliferation (GO:0008283) 732 18 5.62 + 3.2 1.37E-05 2.13E-03 regulation of transcription by RNA polymerase II (GO:0006357) 2603 64 19.97 + 3.2 1.10E-18 8.38E-15 behavior (GO:0007610) 632 15 4.85 + 3.09 1.10E-04 1.31E-02 negative regulation of macromolecule biosynthetic process (GO:0010558) 2061 48 15.81 + 3.04 9.04E-13 4.18E-10 negative regulation of cellular biosynthetic process (GO:0031327) 2113 48 16.21 + 2.96 2.24E-12 8.14E-10 tissue morphogenesis (GO:0048729) 574 13 4.4 + 2.95 4.97E-04 4.65E-02 negative regulation of biosynthetic process (GO:0009890) 2127 48 16.32 + 2.94 2.85E-12 9.66E-10 epithelial cell differentiation (GO:0030855) 643 14 4.93 + 2.84 4.48E-04 4.35E-02 nervous system development (GO:0007399) 2207 48 16.93 + 2.83 1.07E-11 3.15E-09 negative regulation of nitrogen compound metabolic process (GO:0051172) 2188 47 16.79 + 2.8 2.95E-11 8.17E-09 positive regulation of nitrogen compound metabolic process (GO:0051173) 2998 63 23 + 2.74 5.40E-15 3.58E-12 negative regulation of cellular metabolic process (GO:0031324) 2572 54 19.73 + 2.74 1.27E-12 5.37E-10 anatomical structure morphogenesis (GO:0009653) 2239 47 17.18 + 2.74 6.53E-11 1.69E-08 system development (GO:0048731) 3546 74 27.21 + 2.72 5.66E-18 9.59E-15 epithelium development (GO:0060429) 1111 23 8.52 + 2.7 1.35E-05 2.13E-03 regulation of RNA metabolic process (GO:0051252) 3758 77 28.83 + 2.67 2.09E-18 4.56E-15 positive regulation of macromolecule biosynthetic process (GO:0010557) 2604 53 19.98 + 2.65 7.57E-12 2.31E-09 regulation of DNA-templated transcription (GO:0006355) 3440 70 26.39 + 2.65 3.27E-16 2.93E-13 regulation of RNA biosynthetic process (GO:2001141) 3459 70 26.54 + 2.64 4.39E-16 3.52E-13 negative regulation of macromolecule metabolic process (GO:0010605) 2609 52 20.02 + 2.6 2.88E-11 8.13E-09 animal organ development (GO:0048513) 2869 57 22.01 + 2.59 2.23E-12 8.31E-10 negative regulation of metabolic process (GO:0009892) 2828 56 21.7 + 2.58 4.41E-12 1.40E-09 positive regulation of cellular biosynthetic process (GO:0031328) 2686 53 20.61 + 2.57 2.49E-11 7.17E-09 multicellular organism development (GO:0007275) 3964 78 30.42 + 2.56 1.21E-17 1.84E-14 positive regulation of biosynthetic process (GO:0009891) 2707 53 20.77 + 2.55 3.36E-11 9.13E-09 neuron development (GO:0048666) 869 17 6.67 + 2.55 3.80E-04 3.76E-02 regulation of nucleobase-containing compound metabolic process (GO:0019219) 4061 78 31.16 + 2.5 5.12E-17 6.00E-14 positive regulation of macromolecule metabolic process (GO:0010604) 3413 64 26.19 + 2.44 9.73E-13 4.36E-10 tissue development (GO:0009888) 1769 33 13.57 + 2.43 2.00E-06 3.47E-04 regulation of cell differentiation (GO:0045595) 1566 29 12.02 + 2.41 1.13E-05 1.81E-03 regulation of gene expression (GO:0010468) 4898 87 37.58 + 2.31 3.27E-17 4.52E-14 positive regulation of cellular metabolic process (GO:0031325) 3341 59 25.64 + 2.3 1.26E-10 3.14E-08 regulation of nitrogen compound metabolic process (GO:0051171) 5474 96 42 + 2.29 1.78E-19 2.71E-15 regulation of macromolecule biosynthetic process (GO:0010556) 5026 88 38.56 + 2.28 3.46E-17 4.39E-14 positive regulation of metabolic process (GO:0009893) 3719 64 28.54 + 2.24 4.40E-11 1.18E-08 positive regulation of developmental process (GO:0051094) 1337 23 10.26 + 2.24 2.51E-04 2.63E-02 regulation of primary metabolic process (GO:0080090) 5622 96 43.14 + 2.23 1.27E-18 4.84E-15 regulation of cellular biosynthetic process (GO:0031326) 5159 88 39.58 + 2.22 1.99E-16 2.02E-13 regulation of biosynthetic process (GO:0009889) 5190 88 39.82 + 2.21 2.80E-16 2.67E-13 regulation of developmental process (GO:0050793) 2448 41 18.78 + 2.18 1.36E-06 2.47E-04 regulation of macromolecule metabolic process (GO:0060255) 6033 99 46.29 + 2.14 3.97E-18 7.57E-15 cellular developmental process (GO:0048869) 3657 60 28.06 + 2.14 1.58E-09 3.60E-07 cell differentiation (GO:0030154) 3654 59 28.04 + 2.1 5.91E-09 1.25E-06 negative regulation of cellular process (GO:0048523) 4848 78 37.2 + 2.1 2.04E-12 7.99E-10 cell development (GO:0048468) 2240 36 17.19 + 2.09 1.49E-05 2.27E-03 anatomical structure development (GO:0048856) 5231 83 40.14 + 2.07 2.71E-13 1.38E-10 regulation of cellular metabolic process (GO:0031323) 6054 96 46.45 + 2.07 3.54E-16 3.00E-13 negative regulation of biological process (GO:0048519) 5208 80 39.96 + 2 8.44E-12 2.52E-09 regulation of metabolic process (GO:0019222) 6559 99 50.33 + 1.97 2.11E-15 1.46E-12 developmental process (GO:0032502) 5739 86 44.03 + 1.95 2.72E-12 9.64E-10 regulation of multicellular organismal process (GO:0051239) 2966 44 22.76 + 1.93 1.06E-05 1.72E-03 positive regulation of cellular process (GO:0048522) 5707 82 43.79 + 1.87 1.44E-10 3.55E-08 positive regulation of biological process (GO:0048518) 6210 87 47.65 + 1.83 7.47E-11 1.90E-08 regulation of biological quality (GO:0065008) 2849 39 21.86 + 1.78 2.75E-04 2.82E-02 multicellular organismal process (GO:0032501) 6745 89 51.75 + 1.72 1.19E-09 2.74E-07 regulation of cellular process (GO:0050794) 11167 123 85.68 + 1.44 8.85E-10 2.11E-07 regulation of biological process (GO:0050789) 11722 125 89.94 + 1.39 5.69E-09 1.22E-06 biological regulation (GO:0065007) 12141 127 93.16 + 1.36 1.24E-08 2.53E-06 G protein-coupled receptor signaling pathway (GO:0007186) 1248 0 9.58 - < 0.01 7.81E-05 9.60E-03