Analysis Type: PANTHER Overrepresentation Test (Released 20240226) Annotation Version and Release Date: GO Ontology database DOI: 10.5281/zenodo.10536401 Released 2024-01-17 Analyzed List: upload_1 (Homo sapiens) Reference List: Homo sapiens (all genes in database) Test Type: FISHER Correction: FDR GO biological process complete Homo sapiens - REFLIST (20580) upload_1 (112) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (raw P-value) upload_1 (FDR) CRD-mediated mRNA stabilization (GO:0070934) 11 4 0.06 + 66.82 2.66E-07 7.96E-05 negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900152) 12 4 0.07 + 61.25 3.98E-07 1.12E-04 positive regulation of cytoplasmic translation (GO:2000767) 15 4 0.08 + 49 1.08E-06 2.62E-04 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151) 27 4 0.15 + 27.22 1.32E-05 2.40E-03 proximal/distal pattern formation (GO:0009954) 35 5 0.19 + 26.25 1.24E-06 2.92E-04 regulation of cytoplasmic translation (GO:2000765) 33 4 0.18 + 22.27 3.01E-05 5.04E-03 mRNA stabilization (GO:0048255) 62 7 0.34 + 20.75 4.50E-08 1.85E-05 RNA stabilization (GO:0043489) 71 7 0.39 + 18.12 1.17E-07 4.04E-05 negative regulation of mRNA catabolic process (GO:1902373) 74 7 0.4 + 17.38 1.56E-07 5.06E-05 embryonic skeletal system development (GO:0048706) 129 11 0.7 + 15.67 1.17E-10 8.49E-08 embryonic skeletal system morphogenesis (GO:0048704) 94 8 0.51 + 15.64 4.51E-08 1.81E-05 negative regulation of RNA catabolic process (GO:1902369) 86 7 0.47 + 14.96 4.41E-07 1.22E-04 negative regulation of mRNA metabolic process (GO:1903312) 99 8 0.54 + 14.85 6.78E-08 2.58E-05 anterior/posterior pattern specification (GO:0009952) 220 16 1.2 + 13.36 6.47E-14 1.41E-10 skeletal system morphogenesis (GO:0048705) 232 12 1.26 + 9.5 5.19E-09 2.73E-06 regulation of RNA splicing (GO:0043484) 187 9 1.02 + 8.84 8.56E-07 2.17E-04 regulation of mRNA stability (GO:0043488) 172 8 0.94 + 8.55 4.59E-06 9.46E-04 regionalization (GO:0003002) 414 19 2.25 + 8.43 9.82E-13 1.07E-09 regulation of RNA stability (GO:0043487) 184 8 1 + 7.99 7.55E-06 1.48E-03 regulation of mRNA catabolic process (GO:0061013) 193 8 1.05 + 7.62 1.07E-05 2.01E-03 pattern specification process (GO:0007389) 462 19 2.51 + 7.56 6.69E-12 6.80E-09 embryonic organ morphogenesis (GO:0048562) 304 12 1.65 + 7.25 1.03E-07 3.82E-05 embryonic organ development (GO:0048568) 460 17 2.5 + 6.79 4.95E-10 2.79E-07 regulation of mRNA metabolic process (GO:1903311) 306 11 1.67 + 6.61 9.08E-07 2.23E-04 RNA splicing (GO:0008380) 380 13 2.07 + 6.29 1.54E-07 5.11E-05 embryonic morphogenesis (GO:0048598) 596 19 3.24 + 5.86 5.12E-10 2.79E-07 negative regulation of cellular catabolic process (GO:0031330) 220 7 1.2 + 5.85 2.03E-04 3.10E-02 chordate embryonic development (GO:0043009) 664 21 3.61 + 5.81 6.43E-11 5.16E-08 skeletal system development (GO:0001501) 507 16 2.76 + 5.8 1.57E-08 7.05E-06 embryo development ending in birth or egg hatching (GO:0009792) 685 21 3.73 + 5.63 1.14E-10 8.69E-08 embryo development (GO:0009790) 1059 31 5.76 + 5.38 5.53E-15 4.21E-11 mRNA metabolic process (GO:0016071) 621 18 3.38 + 5.33 6.82E-09 3.35E-06 mRNA processing (GO:0006397) 459 12 2.5 + 4.8 7.72E-06 1.49E-03 regulation of amide metabolic process (GO:0034248) 442 11 2.41 + 4.57 2.97E-05 5.02E-03 regulation of translation (GO:0006417) 378 9 2.06 + 4.37 2.25E-04 3.40E-02 post-transcriptional regulation of gene expression (GO:0010608) 517 11 2.81 + 3.91 1.21E-04 1.88E-02 RNA biosynthetic process (GO:0032774) 543 11 2.96 + 3.72 1.85E-04 2.85E-02 RNA metabolic process (GO:0016070) 1520 30 8.27 + 3.63 3.50E-10 2.23E-07 RNA processing (GO:0006396) 875 17 4.76 + 3.57 5.01E-06 1.02E-03 negative regulation of transcription by RNA polymerase II (GO:0000122) 938 18 5.1 + 3.53 3.03E-06 6.80E-04 positive regulation of DNA-templated transcription (GO:0045893) 1701 32 9.26 + 3.46 2.57E-10 1.78E-07 positive regulation of RNA biosynthetic process (GO:1902680) 1704 32 9.27 + 3.45 2.69E-10 1.78E-07 positive regulation of transcription by RNA polymerase II (GO:0045944) 1264 23 6.88 + 3.34 2.62E-07 7.99E-05 positive regulation of RNA metabolic process (GO:0051254) 1842 33 10.02 + 3.29 4.40E-10 2.58E-07 negative regulation of RNA metabolic process (GO:0051253) 1403 25 7.64 + 3.27 1.06E-07 3.84E-05 negative regulation of gene expression (GO:0010629) 966 17 5.26 + 3.23 1.82E-05 3.22E-03 positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2048 35 11.15 + 3.14 3.89E-10 2.37E-07 animal organ morphogenesis (GO:0009887) 996 17 5.42 + 3.14 2.68E-05 4.65E-03 negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 1526 25 8.3 + 3.01 5.18E-07 1.38E-04 regulation of transcription by RNA polymerase II (GO:0006357) 2590 42 14.1 + 2.98 1.64E-11 1.56E-08 nucleic acid metabolic process (GO:0090304) 2167 34 11.79 + 2.88 6.92E-09 3.30E-06 negative regulation of DNA-templated transcription (GO:0045892) 1274 19 6.93 + 2.74 5.47E-05 8.78E-03 regulation of RNA metabolic process (GO:0051252) 3731 55 20.3 + 2.71 7.38E-14 1.41E-10 negative regulation of RNA biosynthetic process (GO:1902679) 1289 19 7.01 + 2.71 6.40E-05 1.02E-02 negative regulation of nitrogen compound metabolic process (GO:0051172) 2180 31 11.86 + 2.61 3.68E-07 1.06E-04 negative regulation of macromolecule biosynthetic process (GO:0010558) 2055 29 11.18 + 2.59 1.15E-06 2.74E-04 regulation of DNA-templated transcription (GO:0006355) 3415 48 18.59 + 2.58 4.74E-11 4.25E-08 negative regulation of cellular metabolic process (GO:0031324) 2564 36 13.95 + 2.58 3.94E-08 1.67E-05 regulation of RNA biosynthetic process (GO:2001141) 3434 48 18.69 + 2.57 5.79E-11 4.90E-08 positive regulation of macromolecule biosynthetic process (GO:0010557) 2591 36 14.1 + 2.55 5.17E-08 2.02E-05 regulation of nucleobase-containing compound metabolic process (GO:0019219) 4033 56 21.95 + 2.55 4.89E-13 6.22E-10 negative regulation of cellular biosynthetic process (GO:0031327) 2107 29 11.47 + 2.53 1.91E-06 4.42E-04 positive regulation of nitrogen compound metabolic process (GO:0051173) 2987 41 16.26 + 2.52 5.40E-09 2.74E-06 negative regulation of biosynthetic process (GO:0009890) 2121 29 11.54 + 2.51 2.19E-06 4.98E-04 positive regulation of cellular biosynthetic process (GO:0031328) 2673 36 14.55 + 2.47 1.15E-07 4.06E-05 negative regulation of macromolecule metabolic process (GO:0010605) 2601 35 14.16 + 2.47 1.89E-07 5.89E-05 positive regulation of biosynthetic process (GO:0009891) 2694 36 14.66 + 2.46 1.40E-07 4.73E-05 regulation of gene expression (GO:0010468) 4866 64 26.48 + 2.42 2.65E-14 8.07E-11 anatomical structure morphogenesis (GO:0009653) 2234 29 12.16 + 2.39 8.62E-06 1.64E-03 nucleobase-containing compound metabolic process (GO:0006139) 2728 35 14.85 + 2.36 7.17E-07 1.88E-04 regulation of macromolecule biosynthetic process (GO:0010556) 4994 64 27.18 + 2.35 1.24E-13 2.09E-10 negative regulation of metabolic process (GO:0009892) 2820 36 15.35 + 2.35 5.02E-07 1.37E-04 regulation of nitrogen compound metabolic process (GO:0051171) 5445 69 29.63 + 2.33 6.28E-15 3.19E-11 positive regulation of macromolecule metabolic process (GO:0010604) 3400 43 18.5 + 2.32 2.44E-08 1.06E-05 regulation of cellular biosynthetic process (GO:0031326) 5127 64 27.9 + 2.29 3.60E-13 5.49E-10 regulation of biosynthetic process (GO:0009889) 5158 64 28.07 + 2.28 7.93E-13 9.29E-10 regulation of primary metabolic process (GO:0080090) 5593 69 30.44 + 2.27 3.69E-14 9.37E-11 positive regulation of cellular metabolic process (GO:0031325) 3328 41 18.11 + 2.26 1.79E-07 5.68E-05 regulation of macromolecule metabolic process (GO:0060255) 6001 73 32.66 + 2.24 3.52E-15 5.36E-11 multicellular organism development (GO:0007275) 3957 48 21.53 + 2.23 9.06E-09 4.18E-06 gene expression (GO:0010467) 2477 30 13.48 + 2.23 2.51E-05 4.41E-03 heterocycle metabolic process (GO:0046483) 2916 35 15.87 + 2.21 3.57E-06 7.67E-04 regulation of cellular metabolic process (GO:0031323) 6021 72 32.77 + 2.2 1.59E-14 6.06E-11 macromolecule biosynthetic process (GO:0009059) 2938 35 15.99 + 2.19 4.03E-06 8.54E-04 cellular aromatic compound metabolic process (GO:0006725) 2955 35 16.08 + 2.18 4.46E-06 9.31E-04 positive regulation of metabolic process (GO:0009893) 3706 43 20.17 + 2.13 3.55E-07 1.04E-04 cellular nitrogen compound metabolic process (GO:0034641) 3271 37 17.8 + 2.08 6.36E-06 1.26E-03 regulation of metabolic process (GO:0019222) 6526 73 35.52 + 2.06 4.06E-13 5.62E-10 organic cyclic compound metabolic process (GO:1901360) 3210 35 17.47 + 2 3.38E-05 5.60E-03 system development (GO:0048731) 3541 37 19.27 + 1.92 4.27E-05 7.00E-03 negative regulation of cellular process (GO:0048523) 4833 50 26.3 + 1.9 8.66E-07 2.16E-04 negative regulation of biological process (GO:0048519) 5193 51 28.26 + 1.8 3.10E-06 6.84E-04 anatomical structure development (GO:0048856) 5216 51 28.39 + 1.8 3.37E-06 7.34E-04 developmental process (GO:0032502) 5723 54 31.15 + 1.73 6.08E-06 1.22E-03 macromolecule metabolic process (GO:0043170) 5622 52 30.6 + 1.7 1.59E-05 2.84E-03 positive regulation of cellular process (GO:0048522) 5686 51 30.94 + 1.65 4.80E-05 7.78E-03 multicellular organismal process (GO:0032501) 6721 58 36.58 + 1.59 2.85E-05 4.88E-03 positive regulation of biological process (GO:0048518) 6186 53 33.67 + 1.57 1.17E-04 1.83E-02 regulation of cellular process (GO:0050794) 11106 86 60.44 + 1.42 8.11E-07 2.09E-04 regulation of biological process (GO:0050789) 11661 86 63.46 + 1.36 1.29E-05 2.37E-03 biological regulation (GO:0065007) 12079 88 65.74 + 1.34 1.15E-05 2.15E-03