{"text_format":"3","workbook":"xlsx","n_sheets":7,"sheets":["Legend","Table-1 Naive","Table-2 Naïve PathwayEnrichment","Table-1 LPS","Table-2 LPS PathwayEnrichment","Table-1 IFN","Table-2 IFN PathwayEnrichment"],"read":"whole","date_system":"1900"}

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["Supplementary table 9: "]
["Description"]
["The allele-specific co-expression relationships were found in naïve, LPS and IFNγ between transcripts. "]
[]
["Explanations for column names:"]
["The results of the coExQTL analysis (Table 1)"]
["Gene: Name of the gene related to the gene in the co-expression pair"]
["Transcript: Name of the transcript in the co-expression pair"]
["GM_cor: refers to the Global Mean Correlation between transcript pairs within a specific condition or group."]
["pvalue: The p-value associated with the observed difference in edge weight between conditions"]
["fdr: The false discovery rate (FDR) corrected p-value"]
["zscore: Z-score of the difference in edge weight between conditions"]
["GM_pVal (Global Module p-value): This value represents the statistical significance of the overall difference in co-expression patterns between two groups or conditions. It indicates the likelihood that the observed differences in transcript co-expression are due to chance rather than true biological effects."]
["GR_cor (transcript Regulation Correlation): This metric quantifies the correlation between the transcript expression levels of two transcripts within a specific condition or group. A higher GR_cor value indicates a stronger positive or negative correlation between the expression of the two transcripts."]
["GR_pVal (Global Rank p-value): This p-value is associated with the overall significance of the differential co-expression analysis between two groups or conditions. It indicates the probability of observing the observed differences in transcript co-expression patterns by chance."]
["zScoreDiff: refers to the z-score of the difference in edge weights between the two conditions being compared."]
["pValDiff: refers to the p-value associated with the difference in edge weights between two conditions or groups. Edge weights represent the strength of the relationship between pairs of transcripts in a co-expression network."]
["pValDiff_adj: refers to the adjusted p-value for the difference in edge weights between two conditions."]
["Classes (correlation classes): refer to groups of transcripts that exhibit similar co-expression patterns across different genotype. These classes are identified based on the correlation coefficients between transcripts within each class."]
["Index:","G2_G0: Allele differential co-expression between donors who carry minor allele homozygotes and donors who carry reference allele homozygotes."]
[null,"G2_G0: Allele specific differential co-expression between donors carrying reference allele homozygot and hetrozygot."]
[]
["ClusterProfiler output for pathway enrichment analysis (Table 2)"]

{"sheet":"Table-1 Naive","index":1,"n_rows":3463,"n_cols":15,"rows_kept":3463}
["Gene","Transcript","GM_cor","GM_pVal","GR_cor","GR_pVal","zScoreDiff","pValDiff","Classes","Transcript gene Name","SNP","REF","ALT","index","pValDiff-FDR"]
["ENSG00000108342","ENST00000504445",-0.999999999999992,{"v":0,"d":"0.00E+00"},0.0605040994940355,0.545787655977623,32.6356464898807,{"v":1.28079703656774e-233,"d":"1.28E-233"},"-/0","ATP10D","rs6823365","G","A","G2_G0",{"v":1.39632492926615e-228,"d":"1.40E-228"}]
["ENSG00000153310","ENST00000513345",-0.99983664632548,{"v":4.00244548615092e-08,"d":"4.00E-08"},0.0535173178657754,0.55989470110618,8.14154009241184,{"v":3.90281258389301e-16,"d":"3.90E-16"},"-/0","HINT1","rs7735755","T","C","G2_G0",{"v":1.41828209298672e-11,"d":"1.42E-11"}]
["ENSG00000185664","ENST00000292147",-0.999987017412766,{"v":5.61532484955052e-08,"d":"5.62E-08"},-0.230794717017071,0.0126824744104537,8.04317320766504,{"v":8.75414532712079e-16,"d":"8.75E-16"},"-/-","ETHE1","rs12460021","G","A","G2_G0",{"v":2.22994053032178E-11,"d":"2.23E-11"}]
["ENSG00000167526","ENST00000411828",-0.999970729607475,{"v":1.90096784313809E-7,"d":"1.90E-07"},0.231129312351044,{"v":0.118023475540922,"d":"1.18E-01"},8.02410105836487,{"v":1.0227208449467E-15,"d":"1.02E-15"},"-/0","PSMG1","rs2836939","G","A","G2_G1",{"v":2.22994053032178E-11,"d":"2.23E-11"}]
["ENSG00000156172","ENST00000347364",-0.368228727248921,{"v":6.48186165439491e-05,"d":"6.48E-05"},-0.999989199219915,{"v":4.26104223016921e-08,"d":"4.26E-08"},-7.95743687572693,{"v":1.75639677592249e-15,"d":"1.76E-15"},"-/-","MKKS","rs221669","G","A","G2_G0",{"v":3.19137294185116e-11,"d":"3.19E-11"}]
["ENSG00000005020","ENST00000513345",-0.999761274293968,{"v":8.54781414538763e-08,"d":"8.55E-08"},-0.028572557015906,0.755725180540746,7.67652762206905,{"v":1.63458821179551E-14,"d":"1.63E-14"},"-/0","HINT1","rs7735755","T","C","G2_G0",{"v":1.78202806849947e-10,"d":"1.78E-10"}]
["ENSG00000184575","ENST00000504445",-0.998401485000416,{"v":1.96053058232337E-7,"d":"1.96E-07"},0.11696296915098,0.241706204037939,7.22158334869292,{"v":5.13857104901723e-13,"d":"5.14E-13"},"-/0","ATP10D","rs6823365","G","A","G2_G0",{"v":4.00147868402756e-09,"d":"4.00E-09"}]
["ENSG00000229344","ENST00000489343",0.960501088976202,{"v":1.9254819960679e-11,"d":"1.93E-11"},-0.0127141838514779,0.916801660153564,-7.23597656726332,{"v":4.6219112837728e-13,"d":"4.62E-13"},"+/0","NPHP3-AS1","rs7622700","G","T","G2_G0",{"v":4.00147868402756e-09,"d":"4.00E-09"}]
["ENSG00000213222","ENST00000554161",-0.998464682111862,{"v":1.77252478916756e-07,"d":"1.77E-07"},0.158352666773167,0.257424858749216,7.20801616383703,{"v":5.67728924889584e-13,"d":"5.68E-13"},"-/0","RP11-1070N10.3","rs179134","T","C","G2_G1",{"v":4.1262538260975e-09,"d":"4.13E-09"}]
["ENSG00000124215","ENST00000394434",0.987642919749848,{"v":1.4905072731608e-08,"d":"1.49E-08"},-0.141369823083181,0.226347093705749,-7.19806606003646,{"v":6.1072556656157e-13,"d":"6.11E-13"},"+/0","LARS","rs72806111","A","G","G2_G1",{"v":4.1613313291589e-09,"d":"4.16E-09"}]
["ENSG00000079691","ENST00000556751",-0.964635008224984,{"v":8.21565038222616E-15,"d":"8.22E-15"},-0.168818815905966,0.236317388949784,7.13970411726128,{"v":9.35320316327503e-13,"d":"9.35E-13"},"-/0","BEGAIN","rs4077299","A","G","G2_G0",{"v":5.99815416976614e-09,"d":"6.00E-09"}]
["ENSG00000139687","ENST00000504202",-0.999045760444116,{"v":5.39977085267651e-08,"d":"5.40E-08"},-0.160835433401489,0.171019703497148,7.12482781303483,{"v":1.04210882122418E-12,"d":"1.04E-12"},"-/0","HINT1","rs6595992","T","C","G2_G1",{"v":6.31170576054778e-09,"d":"6.31E-09"}]
["ENSG00000168917","ENST00000355860",0.866547069702136,{"v":4.18420853520729E-12,"d":"4.18E-12"},-0.149717556407093,0.196750344828221,-7.07940476470097,{"v":1.44774951595067E-12,"d":"1.45E-12"},"+/0","WWOX","rs8050128","C","A","G2_G1",{"v":7.95683326211257e-09,"d":"7.96E-09"}]
["ENSG00000177432","ENST00000421946",-0.342470314770114,{"v":0.000348835239641243,"d":"3.49E-04"},-0.999960074321063,{"v":3.02837548371571e-07,"d":"3.03E-07"},-7.07826522633407,{"v":1.45970157074162e-12,"d":"1.46E-12"},"-/-","ANKRD36","rs13032546","G","C","G2_G0",{"v":7.95683326211257e-09,"d":"7.96E-09"}]
["ENSG00000122783","ENST00000457853",0.80580240543496,{"v":4.1640468850801e-11,"d":"4.16E-11"},-0.250251881468087,{"v":0.0271210593113584,"d":"2.71E-02"},-7.05686426052165,{"v":1.70301831266496e-12,"d":"1.70E-12"},"+/-","LINC01270","rs6012900","A","G","G2_G1",{"v":8.84109792603495e-09,"d":"8.84E-09"}]
["ENSG00000156983","ENST00000484389",-0.999844305782677,{"v":2.33202090105245e-06,"d":"2.33E-06"},0.285666170209255,0.00396368140060366,7.03313245435395,{"v":2.01947486327962e-12,"d":"2.02E-12"},"-/+","TDRD3","rs7993914","T","C","G2_G0",{"v":1.00074158906702E-8,"d":"1.00E-08"}]
["ENSG00000148484","ENST00000511362",-0.996926753182609,{"v":7.23987003681259e-08,"d":"7.24E-08"},-0.00923294913484459,0.930782002440522,7.02366700062448,{"v":2.16119550233765e-12,"d":"2.16E-12"},"-/0","ATXN3","rs7493524","G","A","G2_G0",{"v":1.02440666810805E-8,"d":"1.02E-08"}]
["ENSG00000276171","ENST00000570276",0.758338298902551,{"v":8.88178419700125e-16,"d":"8.88E-16"},-0.154663695953167,0.182196139232484,-6.98363746040953,{"v":2.87633740975512e-12,"d":"2.88E-12"},"+/0","ULK3","rs12908814","C","G","G2_G1",{"v":1.2060704015827E-8,"d":"1.21E-08"}]
["ENSG00000100591","ENST00000528869",-0.436530099056936,{"v":6.27222604876465E-6,"d":"6.27E-06"},-0.999999373397414,{"v":6.26602586262237e-07,"d":"6.27E-07"},-6.98383423976651,{"v":2.87230939178899E-12,"d":"2.87E-12"},"-/-","RP1-68D18.4","rs1467558","T","C","G2_G0",{"v":1.2060704015827E-8,"d":"1.21E-08"}]
["ENSG00000116237","ENST00000513345",-0.999402347007584,{"v":5.35676911495031e-07,"d":"5.36E-07"},0.0264019588157143,0.773762358073918,6.98559557930291,{"v":2.83650074565648e-12,"d":"2.84E-12"},"-/0","HINT1","rs7735755","T","C","G2_G0",{"v":1.2060704015827E-8,"d":"1.21E-08"}]
["ENSG00000130487","ENST00000370481",-0.864003734435807,{"v":7.79158289043735e-06,"d":"7.79E-06"},0.609796112322289,{"v":9.42461664266148e-10,"d":"9.42E-10"},6.96408067340375,{"v":3.30555156596348e-12,"d":"3.31E-12"},"-/+","GBP3","rs12146148","C","T","G2_G0",{"v":1.33470826563459e-08,"d":"1.33E-08"}]
["ENSG00000113387","ENST00000475146",-0.487810709128844,{"v":8.5019458140323e-10,"d":"8.50E-10"},0.811315080580273,{"v":2.63818205237243e-06,"d":"2.64E-06"},6.95491663086012,{"v":3.52770591375593e-12,"d":"3.53E-12"},"-/+","CPNE1","rs6060478","T","C","G2_G1",{"v":1.37353749542026E-8,"d":"1.37E-08"}]
["ENSG00000103490","ENST00000505458",-0.802429991305739,{"v":0,"d":"0.00E+00"},0.0418682991533898,0.708793473800331,6.93558703925574,{"v":4.04537730489418E-12,"d":"4.05E-12"},"-/0","NFKB1","rs230519","T","C","G2_G1",{"v":1.52078287510194e-08,"d":"1.52E-08"}]
["ENSG00000143222","ENST00000513345",-0.99923915170246,{"v":8.68114974128531E-7,"d":"8.68E-07"},0.111510225362284,0.22334486115922,6.9254138433874,{"v":4.34702832561015e-12,"d":"4.35E-12"},"-/0","HINT1","rs7735755","T","C","G2_G0",{"v":1.57971009352673e-08,"d":"1.58E-08"}]
["ENSG00000163154","ENST00000505458",-0.816704376543758,{"v":0,"d":"0.00E+00"},-5.53652273826868E-3,0.960627592451597,6.89938338017701,{"v":5.22287439966499e-12,"d":"5.22E-12"},"-/0","NFKB1","rs230519","T","C","G2_G1",{"v":1.77936802203587e-08,"d":"1.78E-08"}]
["ENSG00000169193","ENST00000451507",-0.999937426942605,{"v":5.94170169954111E-7,"d":"5.94E-07"},-0.272814898860834,0.00304751399873293,6.87787656425203,{"v":6.07512730116588e-12,"d":"6.08E-12"},"-/-","RP11-119B16.2","rs67356712","A","G","G2_G0",{"v":1.94797170109737e-08,"d":"1.95E-08"}]
["ENSG00000112511","ENST00000504445",-0.997637226802848,{"v":5.20545851756538e-07,"d":"5.21E-07"},0.137801634632789,0.167225234990331,6.87964574377989,{"v":6.00015833883036e-12,"d":"6.00E-12"},"-/0","ATP10D","rs6823365","G","A","G2_G0",{"v":1.94797170109737e-08,"d":"1.95E-08"}]
["ENSG00000225972","ENST00000489343",0.961133804547349,{"v":1.66888725061654e-11,"d":"1.67E-11"},0.09855037717975,0.416984525063656,-6.85540559538382,{"v":7.11104696592071E-12,"d":"7.11E-12"},"+/0","NPHP3-AS1","rs7622700","G","T","G2_G0",{"v":2.21498954349907e-08,"d":"2.21E-08"}]
["ENSG00000101596","ENST00000587567",0.993302486488688,{"v":8.04272730636768e-08,"d":"8.04E-08"},-0.233843362324532,0.0240718786033898,-6.84214995045973,{"v":7.80133629801265e-12,"d":"7.80E-12"},"+/-","ZNF566","rs11672024","A","G","G2_G0",{"v":2.3625046755815e-08,"d":"2.36E-08"}]
["ENSG00000153132","ENST00000587567",0.98995742576359,{"v":3.30938115133961e-07,"d":"3.31E-07"},-0.231932675380598,0.0252847051937704,-6.83229514553774,{"v":8.3566692990218e-12,"d":"8.36E-12"},"+/-","ZNF566","rs11672024","A","G","G2_G0",{"v":2.46228131616042E-8,"d":"2.46E-08"}]
["ENSG00000107719","ENST00000493091",-0.999999174947769,{"v":8.25052230757351e-07,"d":"8.25E-07"},-0.457458767955488,{"v":2.43599014737583e-07,"d":"2.44E-07"},6.82625205960848,{"v":8.71617320240055e-12,"d":"8.72E-12"},"-/-","PILRB","rs112622797","G","A","G2_G0",{"v":2.4677465262685E-8,"d":"2.47E-08"}]
["ENSG00000177854","ENST00000502576",-0.975738992750689,{"v":6.35553933925337e-08,"d":"6.36E-08"},0.23506671334642,0.0636675557220683,6.82442314366054,{"v":8.82793198720158e-12,"d":"8.83E-12"},"-/0","HSD17B11","rs6840102","C","T","G2_G1",{"v":2.4677465262685E-8,"d":"2.47E-08"}]
["ENSG00000107099","ENST00000511081",-0.999997693563063,{"v":2.30643693654997e-06,"d":"2.31E-06"},0.012282500379339,{"v":0.894527934405968,"d":"8.95E-01"},6.81942845924529,{"v":9.14034169981545e-12,"d":"9.14E-12"},"-/0","CLDND1","rs16839820","T","C","G2_G0",{"v":2.4912001302847e-08,"d":"2.49E-08"}]
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["ENSG00000223599","ENST00000450034",-0.997915291825078,{"v":3.80699071378388e-07,"d":"3.81E-07"},0.0285373067787679,0.785977996679879,6.77343627789383,{"v":1.25758979940257E-11,"d":"1.26E-11"},"-/0","ASGR2","rs2304978","C","T","G2_G0",{"v":2.91707319001847e-08,"d":"2.92E-08"}]
["ENSG00000177294","ENST00000587567",0.992064528268427,{"v":1.45440812282516E-7,"d":"1.45E-07"},-0.202701782576176,0.051339965977462,-6.7645884285761,{"v":1.33688686748685e-11,"d":"1.34E-11"},"+/0","ZNF566","rs11672024","A","G","G2_G0",{"v":2.97443686313095e-08,"d":"2.97E-08"}]
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["ENSG00000197858","ENST00000587567",-0.991061448501873,{"v":2.20389991367753e-07,"d":"2.20E-07"},0.140736257711042,0.178443479591955,6.74680185963523,{"v":1.51139445041856e-11,"d":"1.51E-11"},"-/0","ZNF566","rs11672024","A","G","G2_G0",{"v":3.10890986763455e-08,"d":"3.11E-08"}]
["ENSG00000254287","ENST00000587567",1,{"v":0,"d":"0.00E+00"},-0.190820405324665,0.0669228848657264,-6.73527396023773,{"v":1.63621346667189e-11,"d":"1.64E-11"},"+/0","ZNF566","rs11672024","A","G","G2_G0",{"v":3.30333318771425e-08,"d":"3.30E-08"}]
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["ENSG00000163840","ENST00000587567",0.990834741951741,{"v":2.40528897244019e-07,"d":"2.41E-07"},-0.18384526044801,0.0777269599360497,-6.7181292008366,{"v":1.8407245186937e-11,"d":"1.84E-11"},"+/0","ZNF566","rs11672024","A","G","G2_G0",{"v":3.58349619692834E-8,"d":"3.58E-08"}]
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["ENSG00000178028","ENST00000503513",-0.706921850282008,{"v":5.40578992738183e-05,"d":"5.41E-05"},0.333916248047139,{"v":0.00472787020515342,"d":"4.73E-03"},5.08230757828746,{"v":3.72876970958064e-07,"d":"3.73E-07"},"-/+","DAB2","rs10512696","C","T","G2_G0",{"v":9.983780203797e-06,"d":"9.98E-06"}]
["ENSG00000105698","ENST00000552002",0.535707399469715,{"v":5.77382586186559e-10,"d":"5.77E-10"},-0.270588450589188,{"v":0.0547976550354976,"d":"5.48E-02"},-5.08229400585361,{"v":3.72903623095408e-07,"d":"3.73E-07"},"+/0","CHURC1","rs11158568","G","A","G2_G1",{"v":9.983780203797e-06,"d":"9.98E-06"}]
["ENSG00000242553","ENST00000262294",0.750539346994226,{"v":4.90213893922231e-07,"d":"4.90E-07"},-0.241941794019702,0.113588459139078,-5.08215378820481,{"v":3.73179075596957e-07,"d":"3.73E-07"},"+/0","TRIM37","rs4598970","T","A","G2_G0",{"v":9.98870189579677e-06,"d":"9.99E-06"}]
["ENSG00000121879","ENST00000513345",-0.994466683576297,{"v":4.58416775586112e-05,"d":"4.58E-05"},0.027494376726321,{"v":0.764668862400366,"d":"7.65E-01"},5.0820270899686,{"v":3.73428138571096e-07,"d":"3.73E-07"},"-/0","HINT1","rs7735755","T","C","G2_G0",{"v":9.98958073163652e-06,"d":"9.99E-06"}]
["ENSG00000086730","ENST00000504445",0.988696335796007,{"v":2.59338496504391E-5,"d":"2.59E-05"},-0.0500368769146196,{"v":0.714196482807163,"d":"7.14E-01"},-5.08198015017072,{"v":3.73520453391355e-07,"d":"3.74E-07"},"+/0","ATP10D","rs6823365","G","A","G2_G1",{"v":9.98958073163652e-06,"d":"9.99E-06"}]
["ENSG00000172009","ENST00000525053",-0.729694979343447,{"v":2.33551938113585e-05,"d":"2.34E-05"},0.293551125300369,{"v":0.0143624684972323,"d":"1.44E-02"},5.08195067527315,{"v":3.73578431873804e-07,"d":"3.74E-07"},"-/+","FGD4","rs7308163","A","G","G2_G0",{"v":9.98958073163652e-06,"d":"9.99E-06"}]

{"sheet":"Table-2 Naïve PathwayEnrichment","index":2,"n_rows":74,"n_cols":7,"rows_kept":74}
["Table 2. Results of pathway enrichment analysis of the coExQTL for DAB2 and rs10512696 variant in naïve monocytes (reference gene set: hc2.all.v2024)."]
["Description","zScore","pvalue","p.adjust","qvalue","Enriched genes","Number of enriched genes"]
["WONG_MITOCHONDRIA_GENE_MODULE",15.1156262465019,{"v":4.53756342168592e-16,"d":"4.54E-16"},{"v":7.77284614134797E-13,"d":"7.77E-13"},{"v":7.22666679685347e-13,"d":"7.23E-13"},"COX6B1/SDHB/COX5A/COX5B/COX7C/NDUFA8/MIPEP/PCCB/PRDX5/MRPL40/COX7B/COX8A/MRPS16/NDUFB10/NDUFA6/TIMM13/MRPL12/NDUFB2",18]
["MOOTHA_VOXPHOS",17.8036790924211,{"v":2.69537147276618e-15,"d":"2.70E-15"},{"v":2.30858566642423e-12,"d":"2.31E-12"},{"v":2.14636686226064e-12,"d":"2.15E-12"},"COX6B1/SDHB/COX5A/COX5B/COX7C/NDUFA8/COX7B/COX8A/UQCRH/NDUFA6/UQCRC1/NDUFB2/GATB",13]
["MOOTHA_HUMAN_MITODB_6_2002",12.5780151646792,{"v":5.16039090468851e-15,"d":"5.16E-15"},{"v":2.94658320657714E-12,"d":"2.95E-12"},{"v":2.73953383817323E-12,"d":"2.74E-12"},"COX6B1/SDHB/COX5A/COX5B/COX7C/NDUFA8/MIPEP/PCCB/COX7B/COX8A/MRPS12/MRPS16/ACAA2/UQCRH/NDUFA6/TIMM13/MRPL12/UQCRC1/NDUFB2/MRPL17/GATB/HADHA",22]
["MOOTHA_MITOCHONDRIA",12.2470204531754,{"v":1.24747712091224E-14,"d":"1.25E-14"},{"v":5.34232077030668e-12,"d":"5.34E-12"},{"v":4.96692864194796e-12,"d":"4.97E-12"},"COX6B1/SDHB/COX5A/COX5B/COX7C/NDUFA8/MIPEP/PCCB/COX7B/COX8A/MRPS12/MRPS16/ACAA2/UQCRH/NDUFA6/TIMM13/MRPL12/UQCRC1/NDUFB2/MRPL17/GATB/HADHA",22]
["REACTOME_RESPIRATORY_ELECTRON_TRANSPORT",14.9192013760465,{"v":1.8317206045515e-14,"d":"1.83E-14"},{"v":6.27547479119343e-12,"d":"6.28E-12"},{"v":5.83451215723456E-12,"d":"5.83E-12"},"COX6B1/SDHB/UQCC2/COX5A/COX5B/COX7C/NDUFA8/COX7B/COX8A/NDUFB10/COA3/UQCRH/NDUFA6/UQCRC1/NDUFB2",15]
["WP_ELECTRON_TRANSPORT_CHAIN_OXPHOS_SYSTEM_IN_MITOCHONDRIA",16.0789792343324,{"v":3.37377718711609e-14,"d":"3.37E-14"},{"v":8.60244500463997e-12,"d":"8.60E-12"},{"v":7.99797172828234e-12,"d":"8.00E-12"},"COX6B1/SDHB/COX5A/COX5B/COX7C/NDUFA8/COX7B/COX8A/NDUFB10/UQCRH/NDUFA6/UQCRC1/NDUFB2",13]
["HALLMARK_OXIDATIVE_PHOSPHORYLATION",13.9884408865033,{"v":3.5153015197011E-14,"d":"3.52E-14"},{"v":8.60244500463997e-12,"d":"8.60E-12"},{"v":7.99797172828234e-12,"d":"8.00E-12"},"COX6B1/SDHB/COX5A/COX5B/COX7C/NDUFA8/COX7B/COX8A/MRPS12/ACAA2/UQCRH/NDUFA6/TIMM13/UQCRC1/NDUFB2/HADHA",16]
["WP_NONALCOHOLIC_FATTY_LIVER_DISEASE",14.011672945605,{"v":2.84872358097736e-13,"d":"2.85E-13"},{"v":6.09982936776777e-11,"d":"6.10E-11"},{"v":5.67120891844571e-11,"d":"5.67E-11"},"COX6B1/SDHB/COX5A/COX5B/COX7C/NDUFA8/COX7B/COX8A/NDUFB10/UQCRH/NDUFA6/IKBKB/UQCRC1/NDUFB2",14]
["KEGG_PARKINSONS_DISEASE",14.2918037544437,{"v":5.60752453965688e-13,"d":"5.61E-13"},{"v":1.06729883738136E-10,"d":"1.07E-10"},{"v":9.92302295731094e-11,"d":"9.92E-11"},"COX6B1/SDHB/COX5A/COX5B/COX7C/NDUFA8/COX7B/COX8A/NDUFB10/UQCRH/NDUFA6/UQCRC1/NDUFB2",13]
["KEGG_OXIDATIVE_PHOSPHORYLATION",14.170516365434,{"v":6.83949105608566e-13,"d":"6.84E-13"},{"v":1.17160481790747E-10,"d":"1.17E-10"},{"v":1.08927894398501E-10,"d":"1.09E-10"},"COX6B1/SDHB/COX5A/COX5B/COX7C/NDUFA8/COX7B/COX8A/NDUFB10/UQCRH/NDUFA6/UQCRC1/NDUFB2",13]
["REACTOME_AEROBIC_RESPIRATION_AND_RESPIRATORY_ELECTRON_TRANSPORT",12.0014803472303,{"v":2.03412181422998E-12,"d":"2.03E-12"},{"v":3.16768242525086e-10,"d":"3.17E-10"},{"v":2.9450969425167E-10,"d":"2.95E-10"},"COX6B1/SDHB/UQCC2/COX5A/COX5B/COX7C/NDUFA8/COX7B/COX8A/NDUFB10/COA3/UQCRH/ADHFE1/NDUFA6/UQCRC1/NDUFB2",16]
["KEGG_HUNTINGTONS_DISEASE",12.7861122655124,{"v":2.59973784683847E-12,"d":"2.60E-12"},{"v":3.71112577636192e-10,"d":"3.71E-10"},{"v":3.45035382654966e-10,"d":"3.45E-10"},"COX6B1/SDHB/COX5A/COX5B/COX7C/NDUFA8/COX7B/COX8A/NDUFB10/UQCRH/AP2S1/NDUFA6/UQCRC1/NDUFB2",14]
["KEGG_ALZHEIMERS_DISEASE",12.4450569731785,{"v":1.29990502098055e-11,"d":"1.30E-11"},{"v":1.71287484687668e-09,"d":"1.71E-09"},{"v":1.59251522003528e-09,"d":"1.59E-09"},"COX6B1/SDHB/COX5A/COX5B/COX7C/NDUFA8/COX7B/COX8A/NDUFB10/UQCRH/NDUFA6/UQCRC1/NDUFB2",13]
["KEGG_MEDICUS_REFERENCE_ELECTRON_TRANSFER_IN_COMPLEX_IV",17.9246523053426,{"v":7.96016722597128E-10,"d":"7.96E-10"},{"v":9.1919123789833e-08,"d":"9.19E-08"},{"v":8.54601863729482e-08,"d":"8.55E-08"},"COX6B1/COX5A/COX5B/COX7C/COX7B/COX8A",6]
["WP_MITOCHONDRIAL_COMPLEX_IV_ASSEMBLY",15.483944031455,{"v":8.04896005164912e-10,"d":"8.05E-10"},{"v":9.1919123789833e-08,"d":"9.19E-08"},{"v":8.54601863729482e-08,"d":"8.55E-08"},"COX6B1/COX5A/COX5B/COX7C/COX7B/COX8A/COA3",7]
["KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_ELECTRON_TRANSFER_IN_COMPLEX_IV",17.4542124247881,{"v":1.13185484304967E-9,"d":"1.13E-09"},{"v":1.21179209134006e-07,"d":"1.21E-07"},{"v":1.12664235364089E-7,"d":"1.13E-07"},"COX6B1/COX5A/COX5B/COX7C/COX7B/COX8A",6]
["KEGG_MEDICUS_ENV_FACTOR_ARSENIC_TO_ELECTRON_TRANSFER_IN_COMPLEX_IV",17.01738842783,{"v":1.57719529611955E-9,"d":"1.58E-09"},{"v":1.58925620132517e-07,"d":"1.59E-07"},{"v":1.47758296162779e-07,"d":"1.48E-07"},"COX6B1/COX5A/COX5B/COX7C/COX7B/COX8A",6]
["KEGG_MEDICUS_REFERENCE_MITOCHONDRIAL_COMPLEX_UCP1_IN_THERMOGENESIS",12.8893982008997,{"v":2.40293197870184e-09,"d":"2.40E-09"},{"v":2.28679026639792e-07,"d":"2.29E-07"},{"v":2.12610297296835e-07,"d":"2.13E-07"},"COX6B1/SDHB/COX5A/NDUFA8/COX8A/NDUFB10/COA3/NDUFA6",8]
["REACTOME_COMPLEX_IV_ASSEMBLY",12.8823316396309,{"v":1.03092782334604E-8,"d":"1.03E-08"},{"v":9.29462821785137e-07,"d":"9.29E-07"},{"v":8.64151687934933e-07,"d":"8.64E-07"},"COX6B1/COX5A/COX5B/COX7C/COX7B/COX8A/COA3",7]
["KEGG_CARDIAC_MUSCLE_CONTRACTION",11.277681401387,{"v":1.70960531672909E-8,"d":"1.71E-08"},{"v":1.46427695377847e-06,"d":"1.46E-06"},{"v":1.36138570747954E-6,"d":"1.36E-06"},"COX6B1/COX5A/COX5B/COX7C/COX7B/COX8A/UQCRH/UQCRC1",8]
["MOOTHA_PGC",8.21298409531066,{"v":1.95056400391299e-08,"d":"1.95E-08"},{"v":1.59110292319188e-06,"d":"1.59E-06"},{"v":1.47929991875707e-06,"d":"1.48E-06"},"PGAM1/SDHB/COX5B/COX7C/FABP3/NDUFA8/MRPL40/COX7B/COX8A/MRPS12/LSM8/NDUFA6/TIMM13/PSMB5/UQCRC1",15]
["REACTOME_TP53_REGULATES_METABOLIC_GENES",10.8966574891918,{"v":2.78944390034191e-08,"d":"2.79E-08"},{"v":2.17196245512986e-06,"d":"2.17E-06"},{"v":2.01934383790302e-06,"d":"2.02E-06"},"COX6B1/COX5A/RRAGA/COX5B/COX7C/PRDX5/COX7B/COX8A",8]
["REACTOME_CYTOPROTECTION_BY_HMOX1",11.4077425940575,{"v":5.10878304145409e-08,"d":"5.11E-08"},{"v":3.80493276087428e-06,"d":"3.80E-06"},{"v":3.53756921817851e-06,"d":"3.54E-06"},"COX6B1/COX5A/HMOX2/COX5B/COX7C/COX7B/COX8A",7]
["REACTOME_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS",8.08690616273229,{"v":3.71164225391577E-7,"d":"3.71E-07"},{"v":2.64918465873238e-05,"d":"2.65E-05"},{"v":2.46303277639235e-05,"d":"2.46E-05"},"COX6B1/MUL1/COX5A/HMOX2/COX5B/COX7C/PRDX5/COX7B/COX8A/PSMB5",10]
["JIANG_MELANOMA_TRM3_CD8",6.87320463915391,{"v":9.96904188884249e-07,"d":"9.97E-07"},{"v":6.83078750223488e-05,"d":"6.83E-05"},{"v":6.35080436960787E-5,"d":"6.35E-05"},"PPP1CA/PGAM1/COX6B1/COX5A/ANAPC11/COX5B/PRDX5/COX7B/COX8A/BIRC3/NDUFA6/PTMS/CHCHD2",13]
["WP_5Q35_COPY_NUMBER_VARIATION",8.02865848108656,{"v":3.5297952723195e-06,"d":"3.53E-06"},0.000232559203903204,2.16217823765968E-4,"COX6B1/COX5A/COX5B/COX7C/COX7B/COX8A/FBXW7",7]
["LI_DCP2_BOUND_MRNA",7.73100518441624,{"v":1.2293159106016E-5,"d":"1.23E-05"},0.000779932649948346,0.000725128644343164,"HMOX2/MRPS12/AP2S1/MRPL12/UQCRC1/TRAPPC2L",6]
["STEIN_ESRRA_TARGETS_UP",5.99547944339743,{"v":1.36897011700424e-05,"d":"1.37E-05"},0.000837516360867234,0.00077866608534865,"SDHB/COX5A/HMOX2/COX5B/NDUFA8/MIPEP/DCTPP1/COX7B/MRPS12/ACAA2/UQCRC1",11]
["ALONSO_METASTASIS_UP",6.58633704315231,{"v":1.62866569061285e-05,"d":"1.63E-05"},0.000962035975179245,0.000894436003592465,"COX6B1/VKORC1/RRAGA/PRDX5/COX8A/DAD1/METTL13/CHCHD2",8]
["YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_2",8.1362683352984,{"v":2.03816051824061e-05,"d":"2.04E-05"},0.00116378965591539,1.08201293477124E-3,"CLK4/TTC14/PAXBP1/CLK1/CCNL2",5]
["CHICAS_RB1_TARGETS_LOW_SERUM",7.08379685120673,{"v":2.83378246383616e-05,"d":"2.83E-05"},0.00156589334211333,0.0014558617547654,"COX6B1/UQCC2/COX5B/COX7C/NDUFB2/OST4",6]
["REACTOME_TRANSCRIPTIONAL_REGULATION_BY_TP53",5.59297016574499,{"v":4.33852745574978e-05,"d":"4.34E-05"},0.00232246797865605,0.00215927369754915,"SUPT4H1/COX6B1/COX5A/RRAGA/COX5B/COX7C/PRDX5/COX7B/COX8A/L3MBTL1",10]
["YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13",5.96719730275689,{"v":7.55271525197837e-05,"d":"7.55E-05"},0.00392054582625422,0.00364505842942369,"COX5B/PCCB/COX7B/COA3/LSM8/COMMD1/NEDD8",7]
["WP_MITOCHONDRIAL_COMPLEX_III_ASSEMBLY",9.64248316021632,{"v":9.70652606827903e-05,"d":"9.71E-05"},0.00489037622204764,0.00454674115829913,"UQCC2/UQCRH/UQCRC1",3]
["KEGG_MEDICUS_REFERENCE_ELECTRON_TRANSFER_IN_COMPLEX_I",7.49825025067204,1.16304344587056E-4,0.00553457736454916,5.14567582423134E-3,"NDUFA8/NDUFB10/NDUFA6/NDUFB2",4]
["BURTON_ADIPOGENESIS_6",5.69057747808755,1.17323542322136E-4,0.00553457736454916,5.14567582423134E-3,"SDHB/COX5B/COX7B/APOC1/ACAA2/UQCRC1/NDUFB2",7]
["KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SNCA_TO_ELECTRON_TRANSFER_IN_COMPLEX_I",7.40331494399565,0.00012708844602551,0.00553457736454916,5.14567582423134E-3,"NDUFA8/NDUFB10/NDUFA6/NDUFB2",4]
["KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_TDP43_TO_ELECTRON_TRANSFER_IN_COMPLEX_I",7.40331494399565,0.00012708844602551,0.00553457736454916,5.14567582423134E-3,"NDUFA8/NDUFB10/NDUFA6/NDUFB2",4]
["KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PINK1_TO_ELECTRON_TRANSFER_IN_COMPLEX_I",7.40331494399565,0.00012708844602551,0.00553457736454916,5.14567582423134E-3,"NDUFA8/NDUFB10/NDUFA6/NDUFB2",4]
["KARLSSON_TGFB1_TARGETS_DN",5.63037953120555,1.29237066305876E-4,0.00553457736454916,5.14567582423134E-3,"RASL11A/RSRP1/ACAA2/DCAF8/TXNDC12/CCNL2/DAB2",7]
["KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_ELECTRON_TRANSFER_IN_COMPLEX_I",6.89133315896067,0.000207584944766786,0.008673000253305,0.00806356922803974,"NDUFA8/NDUFB10/NDUFA6/NDUFB2",4]
["REACTOME_MITOCHONDRIAL_TRANSLATION",6.03473804186113,0.000228624391227346,0.0093246090993439,0.00866939107586403,"MRPL40/MRPS12/MRPS16/MRPL12/MRPL17",5]
["REACTOME_MITOCHONDRIAL_PROTEIN_DEGRADATION",5.95775103673331,0.00025170787763854,0.0100273394045307,0.00932274219992929,"COX5A/COX5B/PCCB/MRPL12/CHCHD2",5]
["WP_MITOCHONDRIAL_COMPLEX_I_ASSEMBLY_MODEL_OXPHOS_SYSTEM",6.52648171396397,0.000298441891011032,0.0115470479484302,0.0107356644520078,"NDUFA8/NDUFB10/NDUFA6/NDUFB2",4]
["CHEN_HOXA5_TARGETS_9HR_UP",5.10692406045818,3.03337511780127E-4,0.0115470479484302,0.0107356644520078,"CLK4/BIRC3/RSRC2/SREK1/CLK1/FNBP4/PPWD1",7]
["REACTOME_COMPLEX_III_ASSEMBLY",7.57891878558466,0.000383933606663563,0.0141888583673719,0.0131918411588372,"UQCC2/UQCRH/UQCRC1",3]
["WP_OXIDATIVE_PHOSPHORYLATION",6.2665206467641,0.000389303177621996,0.0141888583673719,0.0131918411588372,"NDUFA8/NDUFB10/NDUFA6/NDUFB2",4]
["HSIAO_HOUSEKEEPING_GENES",4.51696688923661,0.000474676043480716,0.016940001301718,0.0157496678461913,"PGAM1/COX6B1/COX7C/COX8A/UQCRH/PSMB5/GUSB/MLF2/NEDD8",9]
["BURTON_ADIPOGENESIS_5",5.29183973859685,0.000592139965326001,0.0203278940802332,0.0188995014860926,"NDUFA8/PRADC1/NDUFB10/UQCRH/MRPL12",5]
["ZHANG_RESPONSE_TO_CANTHARIDIN_DN",5.86609799290427,0.000593341917111302,0.0203278940802332,0.0188995014860926,"PGAM1/UQCRH/NDUFB2/HADHA",4]
["REACTOME_COMPLEX_I_BIOGENESIS",5.81372267687465,0.000627657204715672,0.0210818978760382,0.0196005232349806,"NDUFA8/NDUFB10/NDUFA6/NDUFB2",4]
["MARTINEZ_RESPONSE_TO_TRABECTEDIN_UP",5.66290394989268,0.000739032313818104,0.0243454298763541,0.0226347346317164,"COX6B1/VKORC1/RSRP1/COX8A",4]
["KAAB_HEART_ATRIUM_VS_VENTRICLE_DN",4.53182982640668,0.000791767200260835,0.0255084769565864,0.0237160571698253,"SDHB/COX5A/FABP3/COX8A/ACAA2/UQCRC1/HADHA",7]
["BURTON_ADIPOGENESIS_12",6.60599342401202,8.04120114218136E-4,0.0255084769565864,0.0237160571698253,"RSRP1/FAM76B/ARGLU1",3]
["PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP",4.65707007747332,9.13658670178843E-4,0.0284563145821156,0.0264567572819252,"ABCA5/CREBZF/CCDC14/PAXBP1/TUG1/PRPF39",6]
["REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION",6.08172979024607,0.00123370278182541,0.0370760151801216,0.034470772094217,"PCCB/ACAA2/HADHA",3]
["REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE",6.08172979024607,0.00123370278182541,0.0370760151801216,0.034470772094217,"APOC1/AP2S1/NCEH1",3]
["BIOCARTA_ETC_PATHWAY",8.14615327311315,1.41893087741642E-3,0.0411970947968529,0.038302273283337,"SDHB/UQCRC1",2]
["KEGG_MEDICUS_REFERENCE_ISOLEUCINE_DEGRADATION",8.14615327311315,1.41893087741642E-3,0.0411970947968529,0.038302273283337,"ACAA2/HADHA",2]
["BASSO_B_LYMPHOCYTE_NETWORK",4.58405528507471,0.00153772704294853,0.0429098079067628,0.0398946381312761,"N4BP2L2/MRPS12/PSMB5/MRPL12/GSAP",5]
["BOYAULT_LIVER_CANCER_SUBCLASS_G1_DN",5.81359818193165,0.00154925255502813,0.0429098079067628,0.0398946381312761,"SDHB/VKORC1/HMOX2",3]
["KAYO_CALORIE_RESTRICTION_MUSCLE_DN",4.98720164710333,1.57811902984592E-3,0.0429098079067628,0.0398946381312761,"COX8A/ACAA2/TUG1/COMMD1",4]
["TAKAO_RESPONSE_TO_UVB_RADIATION_UP",4.98720164710333,1.57811902984592E-3,0.0429098079067628,0.0398946381312761,"COX5A/COX5B/COX7B/COX8A",4]
["RODWELL_AGING_KIDNEY_NO_BLOOD_DN",4.5406692334057,1.63268820556034E-3,0.0432044777736776,0.0401686022500226,"ABCA5/COX7C/COX7B/COX8A/GATB",5]
["BILBAN_B_CLL_LPL_DN",5.73053355672271,0.00166462085993154,0.0432044777736776,0.0401686022500226,"PNISR/ARGLU1/FNBP4",3]
["GAZDA_DIAMOND_BLACKFAN_ANEMIA_MYELOID_DN",5.73053355672271,0.00166462085993154,0.0432044777736776,0.0401686022500226,"COX5B/CHMP4A/HADHA",3]
["KEGG_MEDICUS_REFERENCE_BETA_OXIDATION",7.74434771559563,1.72775884431761E-3,0.0435242779458244,0.0404659308274387,"ACAA2/HADHA",2]
["KEGG_MEDICUS_REFERENCE_ELECTRON_TRANSFER_IN_COMPLEX_III",7.74434771559563,1.72775884431761E-3,0.0435242779458244,0.0404659308274387,"UQCRH/UQCRC1",2]
["MARIADASON_REGULATED_BY_HISTONE_ACETYLATION_DN",5.65031246291565,0.0017852265439215,0.0443201894164859,0.0412059154989051,"LUC7L2/PAN3/SCCPDH",3]
["KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION",5.49775530521744,0.00204248401119099,0.0491430004099743,0.045689839075977,"PCCB/ACAA2/HADHA",3]
["KEGG_MEDICUS_PATHOGEN_HSV_GD_TO_HVEM_NFKB_SIGNALING_PATHWAY",7.39290938568764,0.00206555518360662,0.0491430004099743,0.045689839075977,"BIRC3/IKBKB",2]
["KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_ELECTRON_TRANSFER_IN_COMPLEX_III",7.39290938568764,0.00206555518360662,0.0491430004099743,0.045689839075977,"UQCRH/UQCRC1",2]

{"sheet":"Table-1 LPS","index":3,"n_rows":11238,"n_cols":16,"rows_kept":4500,"cut":true,"bounds":{"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0}}
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["ENSG00000116698","ENST00000565230",0.619729906117511,{"v":8.61311022504196e-13,"d":"8.61E-13"},-0.112987485432435,{"v":0.411460620315605,"d":"4.11E-01"},-4.94208770575815,{"v":7.72904296078705e-07,"d":"7.73E-07"},{"v":1.4778723832478E-5,"d":"1.48E-05"},"+/0","SIRPB1","rs2254448","C","G","G2_G1",{"v":9.97568315370736e-06,"d":"9.98E-06"}]
["ENSG00000205269","ENST00000427287",-0.886033793886427,{"v":1.8732385198561e-08,"d":"1.87E-08"},-0.109092030168971,{"v":0.419208781717166,"d":"4.19E-01"},4.9420641203361,{"v":7.72997826884169e-07,"d":"7.73E-07"},0.000208456189832677,"-/0","WSB1","rs1047616","G","A","G2_G0",{"v":9.9761829021495e-06,"d":"9.98E-06"}]
["ENSG00000008516","ENST00000249014",-0.000708767726456512,0.995786943011864,0.82123656494144,{"v":2.69340709735388e-08,"d":"2.69E-08"},4.94203064735858,{"v":7.73130586687639e-07,"d":"7.73E-07"},2.19864281934207E-4,"0/+","CDC42EP1","rs2281097","T","C","G2_G0",{"v":9.97657715227348e-06,"d":"9.98E-06"}]
["ENSG00000100632","ENST00000409582",-0.442301806518875,{"v":2.41329585204397e-07,"d":"2.41E-07"},-0.999962136869081,{"v":3.78631309192468e-05,"d":"3.79E-05"},-4.94202877809194,{"v":7.73138001180244e-07,"d":"7.73E-07"},4.03088382548673E-3,"-/-","DYSF","rs6741436","C","T","G2_G0",{"v":9.97657715227348e-06,"d":"9.98E-06"}]
["ENSG00000167522","ENST00000419852",0.329035406440626,{"v":0.00164172699739717,"d":"1.64E-03"},-0.430267955854952,{"v":0.000180306004739839,"d":"1.80E-04"},-4.94199530443409,{"v":7.73270786872891e-07,"d":"7.73E-07"},{"v":1.39019866407803e-05,"d":"1.39E-05"},"+/-","HLA-DQB1-AS1","rs4947344","T","C","G2_G1",{"v":9.97746731016907e-06,"d":"9.98E-06"}]
["ENSG00000215158","ENST00000434333",0.241337018923178,0.102211008783412,-0.795619358385841,{"v":5.66818082159415e-06,"d":"5.67E-06"},-4.94198375171559,{"v":7.73316620119416e-07,"d":"7.73E-07"},0.000557800603363405,"0/-","HLA-B","rs1894743","A","T","G2_G0",{"v":9.97746731016907e-06,"d":"9.98E-06"}]
["ENSG00000122557","ENST00000273853",0.984510340240542,{"v":5.68781142349373e-05,"d":"5.69E-05"},-0.0868906376997772,{"v":0.349480604570048,"d":"3.49E-01"},-4.94196287411942,{"v":7.73399454709059e-07,"d":"7.73E-07"},0.00130119835684775,"+/0","CENPC","rs768244","C","T","G2_G0",{"v":9.97782876035232e-06,"d":"9.98E-06"}]
["ENSG00000006712","ENST00000517985",0.796871867721143,{"v":9.51461132103759e-13,"d":"9.51E-13"},-0.00853558704441163,{"v":0.960011805515975,"d":"9.60E-01"},-4.94188041061789,{"v":7.73726722982322e-07,"d":"7.74E-07"},1.00848830618054E-3,"+/0","DENND3","rs307740","G","A","G2_G0",{"v":9.9813434387083e-06,"d":"9.98E-06"}]
["ENSG00000110200","ENST00000565230",-0.544215002765248,{"v":1.146031269883e-09,"d":"1.15E-09"},0.224001371794064,{"v":0.100166397474849,"d":"1.00E-01"},4.9418007167357,{"v":7.74043126374005e-07,"d":"7.74E-07"},{"v":1.47824280092989E-5,"d":"1.48E-05"},"-/0","SIRPB1","rs2254448","C","G","G2_G1",{"v":9.98303884674038e-06,"d":"9.98E-06"}]
["ENSG00000169914","ENST00000225696",0.761281638387158,{"v":2.54904182561688e-06,"d":"2.55E-06"},-0.178126351068562,{"v":0.166012672690023,"d":"1.66E-01"},-4.94176246039019,{"v":7.74195057304739e-07,"d":"7.74E-07"},{"v":6.79529281590674e-06,"d":"6.80E-06"},"+/0","NUP88","rs3944127","C","G","G2_G1",{"v":9.98303884674038e-06,"d":"9.98E-06"}]
["ENSG00000137996","ENST00000225696",-0.767971338769769,{"v":1.83621523608402E-6,"d":"1.84E-06"},0.162486520662588,{"v":0.207025340036863,"d":"2.07E-01"},4.94176202726768,{"v":7.74196777568302e-07,"d":"7.74E-07"},{"v":6.79529281590674e-06,"d":"6.80E-06"},"-/0","NUP88","rs3944127","C","G","G2_G1",{"v":9.98303884674038e-06,"d":"9.98E-06"}]
["ENSG00000171150","ENST00000262127",0.759851484584732,{"v":9.14916364891383e-10,"d":"9.15E-10"},0.0482207166850784,{"v":0.677075971487301,"d":"6.77E-01"},-4.94179469729119,{"v":7.74067030041514e-07,"d":"7.74E-07"},0.00605359120843966,"+/0","CEP76","rs9710023","C","T","G2_G1",{"v":9.98303884674038e-06,"d":"9.98E-06"}]
["ENSG00000176542","ENST00000481408",0.183308998652177,0.251297017341538,-0.746029835194653,{"v":5.01307786393568e-08,"d":"5.01E-08"},-4.94171873558021,{"v":7.74368740828353e-07,"d":"7.74E-07"},0.00209705584722418,"0/-","SGSM3","rs2018393","G","T","G2_G0",{"v":9.98396464453562e-06,"d":"9.98E-06"}]
["ENSG00000085871","ENST00000563194",-0.573599786001266,{"v":8.83879205284543e-05,"d":"8.84E-05"},0.313784967825672,{"v":0.00433639683551146,"d":"4.34E-03"},4.94169088418819,{"v":7.74479391588936e-07,"d":"7.74E-07"},0.000645225811337451,"-/+","RPS2","rs4786902","T","A","G2_G1",{"v":9.98468398799361e-06,"d":"9.98E-06"}]
["ENSG00000107593","ENST00000225696",-0.794399897580141,{"v":4.48565582011895E-7,"d":"4.49E-07"},0.0899887413411815,{"v":0.479468442164492,"d":"4.79E-01"},4.94152644172601,{"v":7.75133015337436e-07,"d":"7.75E-07"},{"v":6.13866100905966e-06,"d":"6.14E-06"},"-/0","NUP88","rs3944127","C","G","G2_G0",{"v":9.99240280859707e-06,"d":"9.99E-06"}]
["ENSG00000143368","ENST00000362011",-0.768306058265097,0.000314999028428353,0.391893856176718,{"v":2.273007813689E-4,"d":"2.27E-04"},4.94135703214987,{"v":7.75806937975455e-07,"d":"7.76E-07"},0.00404479877229137,"-/+","SHISA4","rs10800796","G","A","G2_G1",{"v":9.99967400239718e-06,"d":"1.00E-05"}]

{"sheet":"Table-2 LPS PathwayEnrichment","index":4,"n_rows":10,"n_cols":7,"rows_kept":10}
["Table 2. Results of pathway enrichment analysis of the coExQTL for USMG5 and rs61869825 variant in naïve monocytes (reference gene set: hc2.all.v2024)."]
["Description","zScore","pvalue","p.adjust","qvalue","Enriched genes","Number of enriched genes"]
["RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN",6.22649259735196,{"v":8.59084413293055E-6,"d":"8.59E-06"},0.0190716739751058,0.017308290179399,"ALOX5/PDXK/HK2/FKBP4/PCK2/ARHGEF6/SLC16A5/FCGR1A/CD163/SLC43A3/SETD1B",11]
["WINTER_HYPOXIA_METAGENE",5.93426040257844,{"v":3.24969738255179e-05,"d":"3.25E-05"},0.0332981244610509,0.0302193505066152,"TGFBI/F3/HK2/FKBP4/GBE1/ENG/CXCL8/ENO1/P4HA2",9]
["HALLMARK_HYPOXIA",5.90084283565516,{"v":5.25031048522527e-05,"d":"5.25E-05"},0.0332981244610509,0.0302193505066152,"TGFBI/F3/ENO2/HK2/GBE1/IRS2/ENO1/P4HA2",8]
["MANALO_HYPOXIA_UP",5.80064811966014,{"v":6.24636378323329e-05,"d":"6.25E-05"},0.0332981244610509,0.0302193505066152,"TGFBI/SMAD6/ENO2/HTRA1/N4BP3/GBE1/P4HA2/PGM3",8]
["SMIRNOV_CIRCULATING_ENDOTHELIOCYTES_IN_CANCER_UP",5.86394894638656,{"v":8.91575601348969e-05,"d":"8.92E-05"},0.0332981244610509,0.0302193505066152,"TGFBI/CHKA/ALOX5/ENG/CXCL8/ADGRE2/RNASE2",7]
["VERHAAK_GLIOBLASTOMA_MESENCHYMAL",5.59143633855021,{"v":8.99949309758132e-05,"d":"9.00E-05"},0.0332981244610509,0.0302193505066152,"TGFBI/ALOX5/LTBP2/ENG/PDPN/SYNGR2/FHOD1/P4HA2",8]
["MAINA_VHL_TARGETS_DN",8.98755939650484,0.000143749863714122,0.0455892424921928,0.0413740209246359,"F3/ENO2/GBE1",3]
["ALTEMEIER_RESPONSE_TO_LPS_WITH_MECHANICAL_VENTILATION",5.77035887113675,0.000173801909260291,0.0482300298197308,0.0437706387268681,"TNFSF9/F3/CCR2/CSF3R/GPR65/FCGR1A",6]

{"sheet":"Table-1 IFN","index":5,"n_rows":3484,"n_cols":16,"rows_kept":3484}
["Gene ","Transcript ","GM_cor","GM_pVal","GR_cor","GR_pVal","zScoreDiff","pValDiff","pValDiff_adj","Classes","Transcript gene Name","SNP","REF","ALT","index","FDR-pValDiff"]
["ENSG00000164323","ENST00000260324",-0.999780183074927,{"v":1.37580080661337E-9,"d":"1.38E-09"},-0.164339302659272,{"v":0.117489471062898,"d":"1.17E-01"},8.5930855871106,{"v":8.46644256095644e-18,"d":"8.47E-18"},{"v":1.3242362809592e-13,"d":"1.32E-13"},"-/0","SQRDL","rs684330","C","T","G2_G0",{"v":2.65232479328363E-14,"d":"2.65E-14"}]
["ENSG00000137502","ENST00000527780",0.979057159012584,{"v":3.06343630462891e-08,"d":"3.06E-08"},-0.398351418441271,{"v":0.000636959177258367,"d":"6.37E-04"},-7.59395639487179,{"v":3.1028284961755e-14,"d":"3.10E-14"},{"v":4.8531340508681e-10,"d":"4.85E-10"},"+/-","NAPSB","rs41432149","C","T","G2_G0",{"v":9.20878670974149e-11,"d":"9.21E-11"}]
["ENSG00000104824","ENST00000380466",-0.998003295490374,{"v":1.98715071064726E-8,"d":"1.99E-08"},-0.0244093514046938,{"v":0.841030161141518,"d":"8.41E-01"},7.39815631740334,{"v":1.38088243878585E-13,"d":"1.38E-13"},{"v":2.15983822250494e-09,"d":"2.16E-09"},"-/0","SAT2","rs1050533","C","T","G2_G0",{"v":3.9931933477905e-10,"d":"3.99E-10"}]
["ENSG00000128534","ENST00000598234",-0.999721733060549,{"v":5.57196200379195e-06,"d":"5.57E-06"},0.693452772540034,{"v":5.58193491428938e-11,"d":"5.58E-11"},7.37501565753484,{"v":1.64325738507723e-13,"d":"1.64E-13"},{"v":2.5702188759993e-09,"d":"2.57E-09"},"-/+","CTD-3088G3.8","rs72781032","A","C","G2_G0",{"v":4.63312311579062e-10,"d":"4.63E-10"}]
["ENSG00000198839","ENST00000488757",-0.99999921035467,{"v":7.89645330456779e-07,"d":"7.90E-07"},0.017295207169527,{"v":0.895648972235402,"d":"8.96E-01"},7.32572990678957,{"v":2.37601905244329e-13,"d":"2.38E-13"},{"v":3.71585619611606e-09,"d":"3.72E-09"},"-/0","ZFP57","rs2747457","T","G","G2_G1",{"v":6.38012030275004e-10,"d":"6.38E-10"}]
["ENSG00000167548","ENST00000560821",-0.630937042994075,{"v":0.000185462876087339,"d":"1.85E-04"},0.794540886193676,{"v":5.59439605751777e-10,"d":"5.59E-10"},7.25705607353702,{"v":3.95605738337756e-13,"d":"3.96E-13"},{"v":6.18766935334085e-09,"d":"6.19E-09"},"-/+","BLM","rs389480","G","A","G2_G0",{"v":1.03758185032544E-9,"d":"1.04E-09"}]
["ENSG00000166441","ENST00000515861",-0.999940990750975,{"v":5.44139364233587e-07,"d":"5.44E-07"},-0.00816220578499783,{"v":0.961210036493478,"d":"9.61E-01"},7.16244241022953,{"v":7.92521662381115e-13,"d":"7.93E-13"},{"v":1.23926612346535e-08,"d":"1.24E-08"},"-/0","TLR1","rs66979032","A","G","G2_G1",{"v":2.03135910367454e-09,"d":"2.03E-09"}]
["ENSG00000132155","ENST00000483080",-0.999751428128243,{"v":4.70430680343803e-06,"d":"4.70E-06"},0.537465531401068,{"v":1.61398504561205e-07,"d":"1.61E-07"},7.11977812383743,{"v":1.08100941465153E-12,"d":"1.08E-12"},{"v":1.69080682545646e-08,"d":"1.69E-08"},"-/+","NUTM2B-AS1","rs35788295","A","G","G2_G0",{"v":2.70922579499966e-09,"d":"2.71E-09"}]
["ENSG00000086062","ENST00000517983",-0.999996732217781,{"v":3.26778221948487e-06,"d":"3.27E-06"},0.442401443169245,{"v":3.97698976124516e-05,"d":"3.98E-05"},7.09158428458389,{"v":1.32585288713579E-12,"d":"1.33E-12"},{"v":2.07350133019166E-8,"d":"2.07E-08"},"-/+","KB-1507C5.4","rs2132863","C","G","G2_G0",{"v":3.18145452677207e-09,"d":"3.18E-09"}]
["ENSG00000173064","ENST00000560821",-0.66564235720087,{"v":5.96562564136871e-05,"d":"5.97E-05"},0.748409764627785,{"v":1.84750192921967e-08,"d":"1.85E-08"},7.0409553658338,{"v":1.90926165106104e-12,"d":"1.91E-12"},{"v":1.49313807421229e-08,"d":"1.49E-08"},"-/+","BLM","rs389480","G","A","G2_G0",{"v":4.48592957802111E-9,"d":"4.49E-09"}]
["ENSG00000138796","ENST00000359742",0.275927990275774,0.18184376829577,-0.915978326934652,{"v":0,"d":"0.00E+00"},-6.98771004249102,{"v":2.79409088537933e-12,"d":"2.79E-12"},{"v":4.37023755382181e-08,"d":"4.37E-08"},"0/-","GRIP1","rs1480008","A","G","G2_G0",{"v":6.30229551924391e-09,"d":"6.30E-09"}]
["ENSG00000125877","ENST00000529441",0.142839275602367,0.192195121146452,-0.999997655744597,{"v":2.34425540313055e-06,"d":"2.34E-06"},-6.9300388829019,{"v":4.20724965030768e-12,"d":"4.21E-12"},{"v":6.57466902853582E-8,"d":"6.57E-08"},"0/-","SIDT2","rs4938348","G","C","G2_G0",{"v":9.22583919559435e-09,"d":"9.23E-09"}]
["ENSG00000262222","ENST00000491223",-0.999657963253591,{"v":1.75463696461264e-07,"d":"1.75E-07"},-0.210326984935443,{"v":0.13849322540787,"d":"1.38E-01"},6.9284808172529,{"v":4.25383837568081e-12,"d":"4.25E-12"},{"v":6.65257783572722e-08,"d":"6.65E-08"},"-/0","EBNA1BP2","rs1010621","T","C","G2_G1",{"v":9.22583919559435e-09,"d":"9.23E-09"}]
["ENSG00000110925","ENST00000359742",-0.306008153513654,{"v":0.13683960694747,"d":"1.37E-01"},0.905419360151401,{"v":0,"d":"0.00E+00"},6.87765300592112,{"v":6.08466567229466e-12,"d":"6.08E-12"},{"v":4.75851278901804e-08,"d":"4.76E-08"},"0/+","GRIP1","rs1480008","A","G","G2_G0",{"v":1.29475945255796E-8,"d":"1.29E-08"}]
["ENSG00000050820","ENST00000403410",-0.999887537252119,{"v":1.43165893184971E-6,"d":"1.43E-06"},-0.0286672403128798,{"v":0.772676569818693,"d":"7.73E-01"},6.8120641780056,{"v":9.62081659883868e-12,"d":"9.62E-12"},{"v":1.50459950789238E-7,"d":"1.50E-07"},"-/0","TMEM45A","rs62276521","A","G","G2_G0",{"v":1.90355451789549E-8,"d":"1.90E-08"}]
["ENSG00000228878","ENST00000313056",-0.934129784700254,{"v":1.44752885233856E-8,"d":"1.45E-08"},0.280658661459929,{"v":0.0313080526782095,"d":"3.13E-02"},6.80446310170905,{"v":1.01426779282221E-11,"d":"1.01E-11"},{"v":1.58641625475322E-7,"d":"1.59E-07"},"-/+","OGFOD3","rs56238200","G","A","G2_G0",{"v":1.97220874839131E-8,"d":"1.97E-08"}]
["ENSG00000272375","ENST00000221132",-0.999996095496425,{"v":3.90450357512506e-06,"d":"3.90E-06"},0.264888827393487,{"v":0.0658617239882995,"d":"6.59E-02"},6.77141484132372,{"v":1.27529019095255E-11,"d":"1.28E-11"},{"v":1.99404374257341e-07,"d":"1.99E-07"},"-/0","TNFRSF10A","rs20576","T","G","G2_G1",{"v":2.43772800754979E-8,"d":"2.44E-08"}]
["ENSG00000115760","ENST00000560821",-0.665474404050392,{"v":6.00056164037355E-5,"d":"6.00E-05"},0.716189984643251,{"v":1.40314487806492e-07,"d":"1.40E-07"},6.76342974140672,{"v":1.34762740715714E-11,"d":"1.35E-11"},{"v":7.02608009178163E-8,"d":"7.03E-08"},"-/+","BLM","rs389480","G","A","G2_G0",{"v":2.53306785586292e-08,"d":"2.53E-08"}]
["ENSG00000168734","ENST00000527780",0.957315216617967,{"v":1.03864255396324e-06,"d":"1.04E-06"},-0.445726414722735,{"v":1.10240875839995E-4,"d":"1.10E-04"},-6.73799625814877,{"v":1.60585703470056e-11,"d":"1.61E-11"},{"v":1.25586049398757E-7,"d":"1.26E-07"},"+/-","NAPSB","rs41432149","C","T","G2_G0",{"v":2.96896640190975e-08,"d":"2.97E-08"}]
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["ENSG00000011638","ENST00000528983",0.59177204813162,{"v":5.48421668078447e-08,"d":"5.48E-08"},-0.339334896661094,0.0299715975829866,-5.10387691383301,{"v":3.32764754447484e-07,"d":"3.33E-07"},{"v":2.46671731010099e-05,"d":"2.47E-05"},"+/-","CTD-2531D15.4","rs1985927","T","C","G2_G1",{"v":9.90207816407198e-06,"d":"9.90E-06"}]
["ENSG00000110077","ENST00000551241",0.150419232626434,0.287151507977288,-0.703578096493939,{"v":4.20875934104004E-9,"d":"4.21E-09"},-5.10362962166515,{"v":3.33200100424116E-7,"d":"3.33E-07"},{"v":5.60385244164904e-05,"d":"5.60E-05"},"0/-","OAS1","rs4767023","T","C","G2_G1",{"v":9.90719064743775e-06,"d":"9.91E-06"}]
["ENSG00000112514","ENST00000560821",0.580510702633009,0.000770684329267857,-0.552068577631997,1.82572903276501E-4,-5.10363591312766,{"v":3.33189017793759e-07,"d":"3.33E-07"},{"v":1.09025301826615E-5,"d":"1.09E-05"},"+/-","BLM","rs389480","G","A","G2_G0",{"v":9.90719064743775e-06,"d":"9.91E-06"}]
["ENSG00000214113","ENST00000262432",0.990752084774613,0.000127890444968859,-0.364521551505103,{"v":0.00574419720188457,"d":"5.74E-03"},-5.10348633703779,{"v":3.3345259764836E-7,"d":"3.33E-07"},0.00216829163083063,"+/-","METTL2B","rs11977296","G","A","G2_G0",{"v":9.91208500532008e-06,"d":"9.91E-06"}]
["ENSG00000152484","ENST00000394836",0.818474184434854,{"v":1.07451469943953E-9,"d":"1.07E-09"},0.0285010911448467,{"v":0.83181381855922,"d":"8.32E-01"},-5.10311428265602,{"v":3.34109097425757e-07,"d":"3.34E-07"},0.000203993288413073,"+/0","RAB3IL1","rs741887","G","A","G2_G1",{"v":9.92688513534253e-06,"d":"9.93E-06"}]
["ENSG00000180376","ENST00000525220",-0.902347806798629,{"v":1.01140103252462E-5,"d":"1.01E-05"},0.203207488251971,0.133074114738493,5.10310441257867,{"v":3.34126530415771e-07,"d":"3.34E-07"},0.000522607306223308,"-/0","TYK2","rs34725611","A","G","G2_G1",{"v":9.92688513534253e-06,"d":"9.93E-06"}]
["ENSG00000128585","ENST00000526813",0.0778576448779543,0.468313358449432,-0.99991857861577,{"v":8.14213842295075e-05,"d":"8.14E-05"},-5.10292267228705,{"v":3.34447685563148E-7,"d":"3.34E-07"},0.00261320699114766,"0/-","SIDT2","rs4938348","G","C","G2_G0",{"v":9.93380972613281e-06,"d":"9.93E-06"}]
["ENSG00000133639","ENST00000567124",0.927395266748418,{"v":6.506338492418e-07,"d":"6.51E-07"},-0.0223075666485762,{"v":0.881685190490646,"d":"8.82E-01"},-5.10259243916016,{"v":3.3503200676395E-7,"d":"3.35E-07"},{"v":3.00578582233481e-05,"d":"3.01E-05"},"+/0","KIAA0040","rs12084108","A","G","G2_G0",{"v":9.94854520559018e-06,"d":"9.95E-06"}]
["ENSG00000273352","ENST00000471109",-0.918979923268023,{"v":6.38150963720996e-05,"d":"6.38E-05"},0.331041176332896,{"v":9.77792918966491E-3,"d":"9.78E-03"},5.10243441232224,{"v":3.35311971171811E-7,"d":"3.35E-07"},0.0052446145410983,"-/+","RALGDS","rs35528861","C","T","G2_G0",{"v":9.95263363585215e-06,"d":"9.95E-06"}]
["ENSG00000057252","ENST00000476147",-0.998220021011278,{"v":9.0123942532383e-05,"d":"9.01E-05"},0.141840350946009,{"v":0.20946123360497,"d":"2.09E-01"},5.10241510685642,{"v":3.35346188707456e-07,"d":"3.35E-07"},0.000874079840865983,"-/0","RP11-587D21.1","rs10835211","G","A","G2_G0",{"v":9.95263363585215e-06,"d":"9.95E-06"}]
["ENSG00000115421","ENST00000491776",-0.754622304625461,{"v":0.00181342944529272,"d":"1.81E-03"},0.616135748650198,{"v":1.15944038858729e-06,"d":"1.16E-06"},5.10234082590215,{"v":3.35477877741235E-7,"d":"3.35E-07"},0.00524720948575066,"-/+","CBS","rs2849728","C","T","G2_G1",{"v":9.95267138824009e-06,"d":"9.95E-06"}]
["ENSG00000058056","ENST00000436587",0.974169471041453,{"v":8.89296044292998e-06,"d":"8.89E-06"},-0.107097068569668,0.546603352037654,-5.1023148395719,{"v":3.35523959408124e-07,"d":"3.36E-07"},5.24793024910247E-3,"+/0","C1GALT1","rs13222351","A","G","G2_G1",{"v":9.95267138824009e-06,"d":"9.95E-06"}]
["ENSG00000253701","ENST00000527780",0.909536552880459,{"v":4.09246929657936e-05,"d":"4.09E-05"},-0.278925439418799,0.0193742326273241,-5.10216603831839,{"v":3.35787946980181E-7,"d":"3.36E-07"},0.000102981554484647,"+/-","NAPSB","rs41432149","C","T","G2_G0",{"v":9.95788295358344E-6,"d":"9.96E-06"}]
["ENSG00000197959","ENST00000421999",-0.880617940305112,{"v":1.46837457961624e-05,"d":"1.47E-05"},0.275724986466125,0.0606663355266359,5.1019910771709,{"v":3.36098601171185e-07,"d":"3.36E-07"},2.50136613316772E-3,"-/0","CMSS1","rs11711935","A","T","G2_G0",{"v":9.9618565417832e-06,"d":"9.96E-06"}]
["ENSG00000135537","ENST00000326652",0.552343243840196,0.0034352231724617,-0.648651748536457,{"v":2.50582477803185E-5,"d":"2.51E-05"},-5.1020289887593,{"v":3.36031263296892e-07,"d":"3.36E-07"},5.25586498922669E-3,"+/-","TMEM150B","rs11878956","T","C","G2_G0",{"v":9.9618565417832e-06,"d":"9.96E-06"}]
["ENSG00000151702","ENST00000359742",0.143991778525769,0.492277086982549,-0.834659338760435,{"v":1.91713311892272e-12,"d":"1.92E-12"},-5.10176390412265,{"v":3.36502374780734E-7,"d":"3.37E-07"},{"v":1.34581365157219e-05,"d":"1.35E-05"},"0/-","GRIP1","rs1480008","A","G","G2_G0",{"v":9.96370733611468e-06,"d":"9.96E-06"}]
["ENSG00000169599","ENST00000560821",0.601882324445002,0.000433788822878256,-0.528468710376452,{"v":3.82785074439784E-4,"d":"3.83E-04"},-5.10175712389691,{"v":3.36514433035058e-07,"d":"3.37E-07"},{"v":1.09883554219235e-05,"d":"1.10E-05"},"+/-","BLM","rs389480","G","A","G2_G0",{"v":9.96370733611468e-06,"d":"9.96E-06"}]
["ENSG00000168405","ENST00000313056",-0.80429617418998,{"v":5.73531676018035E-5,"d":"5.74E-05"},0.356251175567782,0.00561659263533976,5.10180693978738,{"v":3.36425847970067E-7,"d":"3.36E-07"},0.000378774680278401,"-/+","OGFOD3","rs56238200","G","A","G2_G0",{"v":9.96370733611468e-06,"d":"9.96E-06"}]
["ENSG00000166579","ENST00000528983",0.672178122218098,{"v":1.37745370665243e-10,"d":"1.38E-10"},-0.215195882981128,0.176629484740249,-5.10185140293437,{"v":3.36346800429653e-07,"d":"3.36E-07"},{"v":2.48150957807557e-05,"d":"2.48E-05"},"+/0","CTD-2531D15.4","rs1985927","T","C","G2_G1",{"v":9.96370733611468e-06,"d":"9.96E-06"}]
["ENSG00000164181","ENST00000400758",0.798677841373041,{"v":3.66573438270734e-12,"d":"3.67E-12"},-0.260893661379624,0.229213157447971,-5.1016328769625,{"v":3.36735473166354e-07,"d":"3.37E-07"},0.000131671988394874,"+/0","PRKAR1B","rs62432162","C","A","G2_G0",{"v":9.96763515176594e-06,"d":"9.97E-06"}]
["ENSG00000114268","ENST00000352957",-0.266958515779918,{"v":0.021489823273467,"d":"2.15E-02"},-0.993904919968915,{"v":5.55242660871258e-06,"d":"5.55E-06"},-5.10146198203799,{"v":3.37039730866182e-07,"d":"3.37E-07"},0.00478616713215895,"-/-","MRPL39","rs4817027","G","A","G2_G0",{"v":9.9740235652997e-06,"d":"9.97E-06"}]
["ENSG00000134247","ENST00000359742",0.32943264847436,{"v":0.107814951032168,"d":"1.08E-01"},-0.764099850383084,{"v":1.59248880748919e-09,"d":"1.59E-09"},-5.10132020923062,{"v":3.37292341548685e-07,"d":"3.37E-07"},{"v":1.34581365157219e-05,"d":"1.35E-05"},"0/-","GRIP1","rs1480008","A","G","G2_G0",{"v":9.97888063680985e-06,"d":"9.98E-06"}]
["ENSG00000143545","ENST00000532826",0.414391851607013,{"v":0.000442797544422779,"d":"4.43E-04"},-0.46083142230672,0.000309298263084346,-5.10116988450478,{"v":3.37560389666352e-07,"d":"3.38E-07"},0.00016150956508349,"+/-","LGALS8","rs2853613","T","C","G2_G1",{"v":9.98164739015824e-06,"d":"9.98E-06"}]
["ENSG00000134802","ENST00000567124",0.929162790007217,{"v":5.56733097623052e-07,"d":"5.57E-07"},-0.00906612326185871,{"v":0.951771959492292,"d":"9.52E-01"},-5.10116849289596,{"v":3.37562872042344e-07,"d":"3.38E-07"},{"v":3.00578582233481e-05,"d":"3.01E-05"},"+/0","KIAA0040","rs12084108","A","G","G2_G0",{"v":9.98164739015824e-06,"d":"9.98E-06"}]
["ENSG00000197971","ENST00000560706",0.913349132261057,{"v":5.05929012284412e-06,"d":"5.06E-06"},-0.156531866770097,{"v":0.272673380433606,"d":"2.73E-01"},-5.10110227062558,{"v":3.37681020852773e-07,"d":"3.38E-07"},0.000264083442357911,"+/0","OIP5-AS1","rs28526381","A","C","G2_G1",{"v":9.9825236830288e-06,"d":"9.98E-06"}]
["ENSG00000052795","ENST00000579905",0.581462214672604,{"v":7.98398458456973e-10,"d":"7.98E-10"},-0.99487034348146,4.40688621110574E-4,-5.10092125080338,{"v":3.38004186582967e-07,"d":"3.38E-07"},1.92139313818316E-3,"+/-","GOSR1","rs216474","C","T","G2_G0",{"v":9.98945863696028e-06,"d":"9.99E-06"}]
["ENSG00000116668","ENST00000359742",0.081428689453446,{"v":0.698798511296745,"d":"6.99E-01"},0.891593453850172,{"v":4.44089209850063e-16,"d":"4.44E-16"},5.10074693013123,{"v":3.38315674819701E-7,"d":"3.38E-07"},{"v":1.34646195161703e-05,"d":"1.35E-05"},"0/+","GRIP1","rs1480008","A","G","G2_G0",{"v":9.99081002631345e-06,"d":"9.99E-06"}]
["ENSG00000111641","ENST00000528983",-0.667966180926154,{"v":1.97307059579543e-10,"d":"1.97E-10"},0.22226496383792,0.162498032526666,5.10076568959225,{"v":3.38282140816253E-7,"d":"3.38E-07"},{"v":2.48407087535541e-05,"d":"2.48E-05"},"-/0","CTD-2531D15.4","rs1985927","T","C","G2_G1",{"v":9.99081002631345e-06,"d":"9.99E-06"}]
["ENSG00000101444","ENST00000326652",0.36827082114319,0.0641499173605284,-0.70006199530671,{"v":2.41986874982558e-10,"d":"2.42E-10"},-5.10065836450504,{"v":3.38474036143462e-07,"d":"3.38E-07"},{"v":2.97648166971762e-05,"d":"2.98E-05"},"0/-","TMEM150B","rs11878956","T","C","G2_G1",{"v":9.99239205878862e-06,"d":"9.99E-06"}]
["ENSG00000100601","ENST00000532826",0.44959985318394,1.19922388762017E-4,-0.425974227224243,9.54180206528488E-4,-5.10061787958054,{"v":3.38546449752448e-07,"d":"3.39E-07"},0.00016150956508349,"+/-","LGALS8","rs2853613","T","C","G2_G1",{"v":9.99239205878862e-06,"d":"9.99E-06"}]
["ENSG00000011638","ENST00000445522",0.559443577054129,{"v":3.78802256228994e-09,"d":"3.79E-09"},-0.490759744181001,{"v":0.0093457900480558,"d":"9.35E-03"},-5.10053914117316,{"v":3.38687328517829e-07,"d":"3.39E-07"},0.000588600945038596,"+/-","MUC20","rs2641733","A","G","G2_G1",{"v":9.99393464754376e-06,"d":"9.99E-06"}]

{"sheet":"Table-2 IFN PathwayEnrichment","index":6,"n_rows":145,"n_cols":7,"rows_kept":145}
["Table 2. Results of pathway enrichment analysis of the coExQTL for OSA1 and rs57484342 variant in naïve monocytes (reference gene set: hc2.all.v2024)."]
["Description","zScore","pvalue","p.adjust","qvalue","Enriched genes","Number of enriched genes"]
["GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP",11.5360097577314,0.00028631009816343,0.0280477148976729,0.00295239104186031,"IGFBP7/OAS1",2]
["ROZANOV_MMP14_TARGETS_UP",10.4004141579754,0.000429209517051765,0.0280477148976729,0.00295239104186031,"IGFBP7/OAS1",2]
["HAN_SATB1_TARGETS_DN",8.57945611961035,0.000904117268340622,0.0280477148976729,0.00295239104186031,"IGFBP7/OAS1",2]
["BAELDE_DIABETIC_NEPHROPATHY_DN",8.06573228671066,0.00114552000089192,0.0280477148976729,0.00295239104186031,"IGFBP7/OAS1",2]
["SEMBA_FHIT_TARGETS_UP",25.9013379410108,1.48635233944139E-3,0.0280477148976729,0.00295239104186031,"OAS1",1]
["HEBERT_MATRISOME_TNBC_LIVER_METASTASIS",22.9513093902355,1.89146538688889E-3,0.0280477148976729,0.00295239104186031,"IGFBP7",1]
["RAY_TARGETS_OF_P210_BCR_ABL_FUSION_DN",22.1705681261048,2.0264787155857E-3,0.0280477148976729,0.00295239104186031,"IGFBP7",1]
["WP_PATHWAYS_OF_NUCLEIC_ACID_METABOLISM_AND_INNATE_IMMUNE_SENSING",21.4641363867695,0.00216147986830506,0.0280477148976729,0.00295239104186031,"OAS1",1]
["BOWIE_RESPONSE_TO_EXTRACELLULAR_MATRIX",20.8209193183989,0.00229646884559542,0.0280477148976729,0.00295239104186031,"OAS1",1]
["BOWIE_RESPONSE_TO_TAMOXIFEN",20.2320110360411,0.00243144564800635,0.0280477148976729,0.00295239104186031,"OAS1",1]
["KARAKAS_TGFB1_SIGNALING",20.2320110360411,0.00243144564800635,0.0280477148976729,0.00295239104186031,"IGFBP7",1]
["THUM_MIR21_TARGETS_HEART_DISEASE_UP",20.2320110360411,0.00243144564800635,0.0280477148976729,0.00295239104186031,"IGFBP7",1]
["WP_INTERACTIONS_BETWEEN_LOXL4_AND_OXIDATIVE_STRESS_PATHWAY",20.2320110360411,0.00243144564800635,0.0280477148976729,0.00295239104186031,"IGFBP7",1]
["XU_HGF_SIGNALING_NOT_VIA_AKT1_48HR_DN",19.6901689058017,0.00256641027608684,0.0280477148976729,0.00295239104186031,"IGFBP7",1]
["WP_IMMUNE_RESPONSE_TO_TUBERCULOSIS",17.8881733102744,0.00310614705608459,0.0280477148976729,0.00295239104186031,"OAS1",1]
["HANSON_HRAS_SIGNALING_VIA_NFKB",17.5095582616087,0.00324105082074866,0.0280477148976729,0.00295239104186031,"OAS1",1]
["ZHANG_INTERFERON_RESPONSE",17.5095582616087,0.00324105082074866,0.0280477148976729,0.00295239104186031,"OAS1",1]
["WEINMANN_ADAPTATION_TO_HYPOXIA_UP",16.8188350432397,0.00351082183751672,0.0280477148976729,0.00295239104186031,"IGFBP7",1]
["DI_MARTINO_MATRISOME_HIGHLY_PROLIFERATIVE_HNSCC",16.5025698233862,0.00364568909071927,0.0280477148976729,0.00295239104186031,"IGFBP7",1]
["EINAV_INTERFERON_SIGNATURE_IN_CANCER",16.5025698233862,0.00364568909071927,0.0280477148976729,0.00295239104186031,"OAS1",1]
["HOLLEMAN_ASPARAGINASE_RESISTANCE_B_ALL_UP",16.2033686808367,0.003780544174533,0.0280477148976729,0.00295239104186031,"IGFBP7",1]
["BENNETT_SYSTEMIC_LUPUS_ERYTHEMATOSUS",15.9197480915826,0.00391538708950645,0.0280477148976729,0.00295239104186031,"OAS1",1]
["MOSERLE_IFNA_RESPONSE",15.3941616404796,0.00418503641513057,0.0280477148976729,0.00295239104186031,"OAS1",1]
["WP_TYPE_I_INTERFERON_INDUCTION_AND_SIGNALING_DURING_SARSCOV2_INFECTION",15.3941616404796,0.00418503641513057,0.0280477148976729,0.00295239104186031,"OAS1",1]
["PEPPER_CHRONIC_LYMPHOCYTIC_LEUKEMIA_UP",15.1500036795408,4.3198428268787E-3,0.0280477148976729,0.00295239104186031,"IGFBP7",1]
["FRIDMAN_IMMORTALIZATION_DN",14.9170033803733,0.00445463707198335,0.0280477148976729,0.00295239104186031,"IGFBP7",1]
["WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_INTERFERON_INDUCTION",14.9170033803733,0.00445463707198335,0.0280477148976729,0.00295239104186031,"OAS1",1]
["WP_TYPE_II_INTERFERON_SIGNALING",14.0812413667031,0.00499369239694647,0.0282825586628316,0.0029771114381928,"OAS1",1]
["WEINMANN_ADAPTATION_TO_HYPOXIA_DN",13.8931523864933,0.00512842581706896,0.0282825586628316,0.0029771114381928,"IGFBP7",1]
["KRASNOSELSKAYA_ILF3_TARGETS_UP",13.5383009712137,5.39785616781485E-3,0.0282825586628316,0.0029771114381928,"OAS1",1]
["ZHU_CMV_8_HR_UP",13.3706648237661,0.00553255309953626,0.0282825586628316,0.0029771114381928,"OAS1",1]
["GOBERT_CORE_OLIGODENDROCYTE_DIFFERENTIATION",13.0530565614086,0.00580191047842216,0.0282825586628316,0.0029771114381928,"OAS1",1]
["MARTIN_NFKB_TARGETS_UP",13.0530565614086,0.00580191047842216,0.0282825586628316,0.0029771114381928,"IGFBP7",1]
["MARCHINI_TRABECTEDIN_RESISTANCE_DN",12.6159439509587,0.00620585534359386,0.0282825586628316,0.0029771114381928,"IGFBP7",1]
["DAUER_STAT3_TARGETS_DN",12.3475129244909,0.00647509112467581,0.0282825586628316,0.0029771114381928,"OAS1",1]
["FARMER_BREAST_CANCER_CLUSTER_1",12.3475129244909,0.00647509112467581,0.0282825586628316,0.0029771114381928,"OAS1",1]
["ASTON_MAJOR_DEPRESSIVE_DISORDER_UP",12.2194814771131,0.00660969077815388,0.0282825586628316,0.0029771114381928,"IGFBP7",1]
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["BROWNE_HCMV_INFECTION_6HR_UP",10.759440145011,0.00849280965916432,0.0282825586628316,0.0029771114381928,"OAS1",1]
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["LINDVALL_IMMORTALIZED_BY_TERT_UP",10.3504299700236,0.00916477493134538,0.0282825586628316,0.0029771114381928,"IGFBP7",1]
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["GAVIN_FOXP3_TARGETS_CLUSTER_P2",9.46949853169478,0.0109104636256601,0.0282825586628316,0.0029771114381928,"IGFBP7",1]
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["SWEET_KRAS_TARGETS_UP",9.35257826855237,0.0111788489907997,0.0282825586628316,0.0029771114381928,"IGFBP7",1]
["ONDER_CDH1_SIGNALING_VIA_CTNNB1",9.29568067702833,0.0113130234651326,0.0282825586628316,0.0029771114381928,"IGFBP7",1]
["MARTIN_VIRAL_GPCR_SIGNALING_UP",9.18485860353893,0.0115813360000703,0.0285337263769847,0.00300355014494576,"IGFBP7",1]
["HECKER_IFNB1_TARGETS",8.7299828800668,0.0127881416894848,0.0298977682067202,0.00314713349544423,"OAS1",1]
["DURCHDEWALD_SKIN_CARCINOGENESIS_UP",8.68340241342564,0.012922170542946,0.0298977682067202,0.00314713349544423,"OAS1",1]
["FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_DN",8.68340241342564,0.012922170542946,0.0298977682067202,0.00314713349544423,"OAS1",1]
["CROONQUIST_NRAS_VS_STROMAL_STIMULATION_DN",8.6375389616512,0.0130561872649032,0.0298977682067202,0.00314713349544423,"IGFBP7",1]
["HALLMARK_INTERFERON_ALPHA_RESPONSE",8.6375389616512,0.0130561872649032,0.0298977682067202,0.00314713349544423,"OAS1",1]
["REACTOME_INTERFERON_GAMMA_SIGNALING",8.59237421231314,0.013190191855906,0.0298977682067202,0.00314713349544423,"OAS1",1]
["LI_ESTROGENE_BIDIRECTIONAL_E2_RESPONSE",8.50407078529709,0.0134581646472437,0.0301037893425188,0.00316881993079145,"OAS1",1]
["DER_IFN_BETA_RESPONSE_UP",8.37643387935642,0.0138600328658164,0.030213171028839,0.00318033379250937,"OAS1",1]
["BROWNE_HCMV_INFECTION_8HR_UP",8.294375562141,0.0141278843723152,0.030213171028839,0.00318033379250937,"OAS1",1]
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["REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP",8.06154673549369,0.0149311478718875,0.030488655438332,0.00320933215140337,"IGFBP7",1]
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["SMIRNOV_RESPONSE_TO_IR_6HR_DN",7.95203156706769,0.0153326159501453,0.0305731447420607,0.00321822576232218,"OAS1",1]
["CERVERA_SDHB_TARGETS_2",7.91647425873847,0.0154664143989248,0.0305731447420607,0.00321822576232218,"IGFBP7",1]
["KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP",7.81250454783703,0.0158677370210293,0.0306314635015545,3.224364579111E-3,"IGFBP7",1]
["FOROUTAN_INTEGRATED_TGFB_EMT_UP",7.7453491539452,0.0161352248377284,0.0306314635015545,3.224364579111E-3,"IGFBP7",1]
["WANG_ESOPHAGUS_CANCER_VS_NORMAL_UP",7.71239198453327,0.0162689505683141,0.0306314635015545,3.224364579111E-3,"IGFBP7",1]
["REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS",7.61590223335042,0.016670055055604,0.0306314635015545,3.224364579111E-3,"IGFBP7",1]
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["INGRAM_SHH_TARGETS_UP",7.58450639571172,0.0168037323183753,0.0306314635015545,3.224364579111E-3,"IGFBP7",1]
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["AZARE_NEOPLASTIC_TRANSFORMATION_BY_STAT3_UP",7.55348156466266,0.0169373974655654,0.0306314635015545,3.224364579111E-3,"OAS1",1]
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["YAGI_AML_WITH_T_9_11_TRANSLOCATION",7.40367370932961,0.0176055414870185,0.0311764797165953,0.00328173470701003,"OAS1",1]
["SENESE_HDAC2_TARGETS_DN",7.34610670411373,0.01787271430575,0.0313233137317268,0.00329719091912914,"IGFBP7",1]
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["BLANCO_MELO_COVID19_BRONCHIAL_EPITHELIAL_CELLS_SARS_COV_2_INFECTION_UP",7.05102069153542,0.0193412989765696,0.0332123315759275,0.00349603490272921,"OAS1",1]
["BROCKE_APOPTOSIS_REVERSED_BY_IL6",7.00094618039506,0.019608156982916,0.0332283814955994,0.00349772436795783,"OAS1",1]
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["RUIZ_TNC_TARGETS_UP",6.76503514847169,0.0209417208594556,0.034231659097187,0.003603332536546,"IGFBP7",1]
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["CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_UP",6.39225803525706,0.0233390873690532,0.0367374523401764,0.00386710024633435,"IGFBP7",1]
["LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP",6.22659621964582,0.0245363016494649,0.0375130658705749,0.00394874377584999,"IGFBP7",1]
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["FOROUTAN_PRODRANK_TGFB_EMT_UP",6.19141198356931,0.0248022163321517,0.0375130658705749,0.00394874377584999,"IGFBP7",1]
["ALCALAY_AML_BY_NPM1_LOCALIZATION_DN",6.17403011097681,0.0249351555492645,0.0375130658705749,0.00394874377584999,"IGFBP7",1]
["XIE_ST_HSC_S1PR3_OE_UP",6.12270322198488,0.0253339007102699,0.0376459186553561,0.00396272827951117,"OAS1",1]
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["GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP",6.0235758456602,0.0261310648751962,0.0376459186553561,0.00396272827951117,"IGFBP7",1]
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["KRIEG_KDM3A_TARGETS_NOT_HYPOXIA",5.94435112302422,0.0267950362194005,0.0376459186553561,0.00396272827951117,"OAS1",1]
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["PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP",5.77993036258864,0.0282547107259616,0.0387362969630119,0.00407750494347494,"IGFBP7",1]
["KIM_WT1_TARGETS_12HR_DN",5.70931606350108,0.0289177163596405,0.039328094249111,0.00413979939464327,"IGFBP7",1]
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["RAO_BOUND_BY_SALL4",5.57507095819417,0.0302428227743989,0.0404825186743923,0.00426131775519919,"MAP10",1]
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["CHYLA_CBFA2T3_TARGETS_DN",5.33116322484932,0.0328894181152318,0.0426809242716749,0.00449272887070262,"OAS1",1]
["VERHAAK_AML_WITH_NPM1_MUTATED_DN",5.2858657194652,0.0334181586838979,0.042883859625899,0.00451409048693674,"IGFBP7",1]
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["ONDER_CDH1_TARGETS_2_UP",5.20910731303081,0.0343429908926911,0.0435694660578917,0.00458625958504123,"IGFBP7",1]
["FOSTER_KDM1A_TARGETS_UP",5.14572186001262,0.035135234526284,0.0442443694034687,0.00465730204247039,"OAS1",1]
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["BLANCO_MELO_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_A594_CELLS_UP",4.92115083814901,0.0381681542158696,0.0466804763791211,0.00491373435569696,"OAS1",1]
["JINESH_BLEBBISHIELD_VS_LIVE_CONTROL_DN",4.89381177025816,0.0385632832333903,0.0468268439262597,0.00492914146592207,"OAS1",1]
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