comparison	direction	pathwayId	pathwayName	pValue	pValueAdjusted	genes	numCandidateGenes	numBgGenes	geneRatio	totalGenes	topLevelPathway
locationPNG_DOLDOL1	Down	R-HSA-6798695	Neutrophil degranulation	2.3769999999999996e-80	2.3789999999999995e-77	ABCA13;CD177;CEACAM1;CHIT1;CLEC4D;CLEC5A;CR1;CRISP3;FCAR;GYG1;HP;LCN2;MCEMP1;MGAM;MMP8;MMP9;OLFM4;RETN;SERPINB10	19	57	0.3333333333333333	101	Immune System
locationPNG_DOLDOL1	Down	R-HSA-2168880	Scavenging of heme from plasma	1.95e-7	1.952e-4	CD163;HP	2	57	0.03508771929824561	101	Vesicle-mediated transport
locationPNG_DOLDOL1	Down	R-HSA-189085	Digestion of dietary carbohydrate	2.455e-7	2.457e-4	CHIT1;MGAM	2	57	0.03508771929824561	101	Digestion and absorption
locationPNG_DOLDOL3	Up	R-HSA-909733	Interferon alpha/beta signaling	3.6329999999999995e-42	3.637e-39	IFI6;IFIT1;IFIT2;IFIT3;ISG15;MX1;OAS1;OAS2;OAS3;OASL;STAT1;USP18;XAF1	13	261	0.04980842911877394	1219	Immune System
locationPNG_DOLDOL3	Up	R-HSA-877300	Interferon gamma signaling	3.338e-41	3.341e-38	GBP1;GBP3;GBP4;GBP5;HLA-DPA1;HLA-DRB5;OAS1;OAS2;OAS3;OASL;STAT1;TRIM22	12	261	0.04597701149425287	1219	Immune System
locationPNG_DOLDOL3	Up	R-HSA-2467813	Separation of Sister Chromatids	5.51e-25	5.515999999999999e-22	AURKB;BIRC5;BUB1;BUB1B;CDC20;CDCA5;CDCA8;CENPM;CENPU;ESPL1;KIF18A;KIF2C;KNTC1;NDC80;SKA1;SPC24;SPC25;UBE2C;ZWINT	19	261	0.07279693486590039	1219	Cell Cycle
locationPNG_DOLDOL3	Up	R-HSA-913531	Interferon Signaling	1.118e-22	1.119e-19	GBP1;GBP3;GBP4;GBP5;HERC5;HLA-DPA1;HLA-DRB5;IFI6;IFIT1;IFIT2;IFIT3;ISG15;MX1;TRIM22;UBE2L6;USP18;XAF1	17	261	0.06513409961685823	1219	Immune System
locationPNG_DOLDOL3	Up	R-HSA-69620	Cell Cycle Checkpoints	1.6089999999999998e-22	1.611e-19	AURKB;BIRC5;BRIP1;BUB1;BUB1B;CCNB2;CCNE1;CCNE2;CDC20;CDC25A;CDC45;CDC6;CDCA8;CENPM;CENPU;CHEK1;EXO1;GTSE1;KIF18A;KIF2C;KNTC1;MCM10;MCM4;MCM6;NDC80;ORC1;ORC6;PKMYT1;SKA1;SPC24;SPC25;UBE2C;ZWINT	33	261	0.12643678160919541	1219	Cell Cycle
locationPNG_DOLDOL3	Up	R-HSA-983189	Kinesins	2.592e-21	2.595e-18	KIF11;KIF15;KIF18A;KIF18B;KIF20A;KIF2C;KIFC1	7	261	0.02681992337164751	1219	Hemostasis
locationPNG_DOLDOL3	Up	R-HSA-69205	G1/S-Specific Transcription	9.389e-21	9.398e-18	CCNE1;CDC45;CDC6;CDT1;ORC1;PCNA;RRM2;TYMS	8	261	0.03065134099616858	1219	Cell Cycle
locationPNG_DOLDOL3	Up	R-HSA-69190	DNA strand elongation	5.704e-19	5.71e-16	FEN1;GINS1;GINS2;GINS3;PCNA	5	261	0.019157088122605363	1219	DNA Replication
locationPNG_DOLDOL3	Up	R-HSA-1169408	ISG15 antiviral mechanism	8.327e-17	8.335e-14	HERC5;IFIT1;ISG15;MX1;STAT1;UBE2L6;USP18	7	261	0.02681992337164751	1219	Immune System
locationPNG_DOLDOL3	Up	R-HSA-69239	Synthesis of DNA	3.178e-15	3.181e-12	CCNE1;CCNE2;CDC6;CDT1;FEN1;GINS1;GINS2;GINS3;MCM4;MCM6;ORC1;ORC6;PCNA;UBE2C	14	261	0.05363984674329502	1219	DNA Replication
locationPNG_DOLDOL3	Up	R-HSA-68949	Orc1 removal from chromatin	1.894e-14	1.896e-11	CDC6;CDT1;MCM4;MCM6;ORC1;ORC6	6	261	0.022988505747126436	1219	DNA Replication
locationPNG_DOLDOL3	Up	R-HSA-68877	Mitotic Prometaphase	2.116e-12	2.118e-9	AURKB;BIRC5;BUB1;BUB1B;CCNB2;CDC20;CDCA5;CDCA8;CDK1;CENPM;CENPU;KIF18A;KIF2C;KNTC1;NCAPH;NDC80;PLK4;SKA1;SPC24;SPC25;ZWINT	21	261	0.08045977011494253	1219	Cell Cycle
locationPNG_DOLDOL3	Up	R-HSA-69242	S Phase	8.536e-11	8.545e-8	CCNE1;CCNE2;CDC25A;CDC6;CDCA5;CDT1;CKS1B;ESCO2;FEN1;GINS1;GINS2;GINS3;MCM4;MCM6;ORC1;ORC6;PCNA;UBE2C	18	261	0.06896551724137931	1219	Cell Cycle
locationPNG_DOLDOL3	Up	R-HSA-196757	Metabolism of folate and pterines	3.58e-9	3.584e-6	FOLR2;SHMT1;SLC46A1	3	261	0.011494252873563218	1219	Metabolism
locationPNG_DOLDOL3	Up	R-HSA-73894	DNA Repair	5.44e-9	5.445e-6	BRCA2;BRIP1;CHEK1;DTL;EXO1;FANCA;FANCI;FANCL;FEN1;ISG15;KIAA0101;PCLAF;PCNA;POLQ;RAD51;RAD51AP1;TIMELESS;UBE2L6;UBE2T;UNG	20	261	0.07662835249042145	1219	DNA Repair
locationPNG_DOLDOL3	Up	R-HSA-69481	G2/M Checkpoints	6.384e-9	6.39e-6	BRIP1;CCNB2;CDC25A;CDC45;CDC6;CDK1;CHEK1;EXO1;GTSE1;MCM10;MCM4;MCM6;ORC1;ORC6;PKMYT1	15	261	0.05747126436781609	1219	Cell Cycle
locationPNG_DOLDOL3	Up	R-HSA-5656169	Termination of translesion DNA synthesis	3.488e-8	3.491e-5	ISG15;KIAA0101;PCLAF;PCNA;UBE2L6	5	261	0.019157088122605363	1219	DNA Repair
locationPNG_DOLDOL3	Up	R-HSA-6783310	Fanconi Anemia Pathway	3.623e-7	3.627e-4	FANCA;FANCI;FANCL;UBE2T	4	261	0.01532567049808429	1219	DNA Repair
locationPNG_DOLDOL3	Down	R-HSA-6798695	Neutrophil degranulation	0	0	ABCA13;ADAM8;ADGRG3;ALOX5;ANPEP;ARG1;ATP6V1D;BPI;BST1;C5AR1;CAT;CD177;CD55;CD59;CDA;CEACAM1;CHI3L1;CHIT1;CKAP4;CLEC4D;CLEC5A;CR1;CREG1;CRISP3;CRISPLD2;CTSB;CTSG;CXCL1;CXCR1;CXCR2;CYSTM1;DNAJC3;DOK3;FCAR;FCGR2A;FOLR3;FPR1;FPR2;GCA;GPR84;GYG1;HP;HSPA1A;HSPA1B;IGF2R;ITGAM;ITGAX;LCN2;LILRB3;LRG1;LTF;MAPK14;MCEMP1;MGAM;MMP25;MMP8;MMP9;MPO;OLFM4;ORM1;PADI2;PGLYRP1;PNP;PYGL;QPCT;RAB27A;RAB3D;RETN;S100A12;S100A8;S100A9;S100P;SDCBP;SERPINB1;SERPINB10;SIGLEC5;SIRPA;SLC11A1;SLC2A3;SLCO4C1;SLPI;STOM;TCN1;VNN1	84	824	0.10194174757281553	1219	Immune System
locationPNG_DOLDOL3	Down	R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	3.698e-17	3.702e-14	ALOX5;BCL2L1;BCL6;CEBPD;CXCL8;FOXO3;IL1B;IL4R;ITGAM;ITGAX;LCN2;MAOA;MMP9;OSM;PIM1;PTGS2;SOCS3	17	824	0.02063106796116505	1219	Immune System
locationPNG_DOLDOL3	Down	R-HSA-4085001	Sialic acid metabolism	5.983e-14	5.989e-11	CMAS;NPL;ST3GAL2;ST3GAL4;ST6GALNAC2;ST6GALNAC3;ST6GALNAC4	7	824	0.00849514563106796	1219	Metabolism of proteins
locationPNG_DOLDOL3	Down	R-HSA-189451	Heme biosynthesis	2.355e-12	2.357e-9	CPOX;FECH;HMBS;UROD	4	824	0.0048543689320388345	1219	Metabolism
locationPNG_DOLDOL3	Down	R-HSA-9020702	Interleukin-1 signaling	1.573e-11	1.575e-8	IL1B;IL1R1;IL1R2;IL1RAP;IRAK3;MAP2K6;PELI1;S100A12;SKP1	9	824	0.010922330097087379	1219	Immune System
locationPNG_DOLDOL3	Down	R-HSA-917937	Iron uptake and transport	3.253e-11	3.256e-8	ABCG2;ATP6V1C1;ATP6V1D;CYBRD1;LCN2;MCOLN1;SKP1;SLC40A1;STEAP3;TFR2;TFRC	11	824	0.013349514563106795	1219	Transport small molecules
locationPNG_DOLDOL3	Down	R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	1.671e-9	1.673e-6	OAZ1;OAZ2;ODC1	3	824	0.0036407766990291263	1219	Metabolism
locationPNG_DOLDOL3	Down	R-HSA-1483191	Synthesis of PC	4.1e-9	4.104e-6	ACHE;CHPT1;LPIN2;PCTP;PCYT1B;PHOSPHO1	6	824	0.007281553398058253	1219	Metabolism
locationPNG_DOLDOL3	Down	R-HSA-913709	O-linked glycosylation of mucins	1.838e-8	1.84e-5	B3GNT5;B3GNTL1;B4GALT5;GALNT14;GALNT5;ST3GAL2;ST3GAL4;ST6GALNAC2;ST6GALNAC3;ST6GALNAC4	10	824	0.012135922330097087	1219	Metabolism of proteins
locationPNG_DOLDOL3	Down	R-HSA-5689896	Ovarian tumor domain proteases	4.78e-8	4.785e-5	PTEN;TNIP1;TRIM25;UBE2D1;YOD1;ZRANB1	6	824	0.007281553398058253	1219	Metabolism of proteins
locationPNG_DOLDOL3	Down	R-HSA-1362409	Mitochondrial iron-sulfur cluster biogenesis	5.576e-8	5.582e-5	GLRX5;ISCA1;ISCU	3	824	0.0036407766990291263	1219	Metabolism
locationPNG_DOLDOL3	Down	R-HSA-8849932	Synaptic adhesion-like molecules	1.15e-7	1.151e-4	FLOT1;FLOT2;PTPRF;RTN3	4	824	0.0048543689320388345	1219	Neuronal System
locationPNG_DOLDOL3	Down	R-HSA-1632852	Macroautophagy	2.625e-7	2.628e-4	ATG9A;GABARAPL1;GABARAPL2;LAMTOR5;MAP1LC3B;MFN2;MTMR3;PINK1;WIPI1;WIPI2	10	824	0.012135922330097087	1219	Autophagy
locationPNG_DOLDOL7	Up	R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	3.806e-58	3.8099999999999996e-55	CD160;KIR2DL1;KLRB1;KLRC1;KLRD1;KLRF1;KLRK1;LAIR2;SH2D1B;SIGLEC1;SIGLEC8	11	242	0.045454545454545456	1632	Immune System
locationPNG_DOLDOL7	Up	R-HSA-380108	Chemokine receptors bind chemokines	4.141e-48	4.1449999999999996e-45	CCL5;CCR3;CCR4;CXCL10;CXCR3;CXCR6;XCL1;XCL2	8	242	0.03305785123966942	1632	Signal Transduction
locationPNG_DOLDOL7	Up	R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	2.456e-33	2.4579999999999997e-30	ADORA3;CCL5;CCR3;CCR4;CXCL10;CXCR3;CXCR6;CYSLTR2;GPBAR1;GPR68;HRH4;NMUR1;OXTR;PTGDR;PTGDR2;S1PR2;S1PR5;XCL1;XCL2	19	242	0.07851239669421488	1632	Signal Transduction
locationPNG_DOLDOL7	Up	R-HSA-909733	Interferon alpha/beta signaling	1.8e-26	1.802e-23	IFI6;IFIT1;IFIT3;ISG15;MX1;OAS1;OAS2;OAS3;OASL;USP18;XAF1	11	242	0.045454545454545456	1632	Immune System
locationPNG_DOLDOL7	Up	R-HSA-69205	G1/S-Specific Transcription	1.718e-14	1.72e-11	CCNE1;CDC45;CDC6;CDT1;RRM2;TYMS	6	242	0.024793388429752067	1632	Cell Cycle
locationPNG_DOLDOL7	Up	R-HSA-2424491	DAP12 signaling	3.486e-12	3.489e-9	KLRD1;KLRK1	2	242	0.008264462809917356	1632	Immune System
locationPNG_DOLDOL7	Up	R-HSA-1169408	ISG15 antiviral mechanism	5.645e-12	5.651e-9	HERC5;IFIT1;ISG15;MX1;USP18	5	242	0.02066115702479339	1632	Immune System
locationPNG_DOLDOL7	Up	R-HSA-391903	Eicosanoid ligand-binding receptors	1.451e-10	1.452e-7	CYSLTR2;PTGDR;PTGDR2	3	242	0.012396694214876033	1632	Signal Transduction
locationPNG_DOLDOL7	Up	R-HSA-5673001	RAF/MAP kinase cascade	6.309e-8	6.315e-5	DLG3;DUSP4;DUSP5;ERBB2;IL2RA;IL2RB;IL5RA;NCAM1	8	242	0.03305785123966942	1632	Signal Transduction
locationPNG_DOLDOL7	Up	R-HSA-877300	Interferon gamma signaling	5.591e-7	5.597e-4	GBP1;GBP4;NCAM1;OAS1;OAS2;OAS3;OASL	7	242	0.028925619834710745	1632	Immune System
locationPNG_DOLDOL7	Down	R-HSA-6798695	Neutrophil degranulation	0	0	ABCA13;ACTR10;ADAM8;ADGRE5;ADGRG3;ALAD;ALOX5;AMPD3;ANPEP;ARG1;ATP6V1D;C5AR1;CAB39;CAT;CD177;CD55;CD58;CD59;CDA;CEACAM1;CEACAM3;CEACAM6;CHIT1;CKAP4;CLEC4D;CLEC5A;CR1;CREG1;CRISP3;CRISPLD2;CTSB;CTSG;CXCL1;CXCR1;CXCR2;CYB5R3;CYSTM1;DNAJC3;DOK3;DYNLL1;ELANE;FCAR;FCER1G;FCGR2A;FCGR3B;FOLR3;FPR1;FPR2;FTH1;FTL;GCA;GPR84;GYG1;HK3;HP;HSPA1A;HSPA1B;HSPA6;IGF2R;ITGAM;ITGAX;KRT1;LGALS3;LILRB3;LRG1;LTF;MAPK14;MCEMP1;MGAM;MMP25;MMP8;MMP9;MPO;OLFM4;ORM1;ORMDL3;PA2G4;PADI2;PGLYRP1;PNP;PRDX6;PTAFR;PTX3;PYGL;QPCT;QSOX1;RAB6A;RETN;S100A11;S100A12;S100A8;S100A9;S100P;SDCBP;SERPINA1;SERPINB1;SIGLEC5;SIGLEC9;SIRPA;SIRPB1;SLC11A1;SLC15A4;SLC2A3;SLCO4C1;SLPI;STOM;TCN1;TLR2;TMBIM1;TNFAIP6;TUBB4B;VNN1;YPEL5	113	1209	0.0934656741108354	1632	Immune System
locationPNG_DOLDOL7	Down	R-HSA-189451	Heme biosynthesis	2.296e-38	2.298e-35	ALAD;ALAS2;CPOX;FECH;HMBS;PPOX;UROD	7	1209	0.005789909015715467	1632	Metabolism
locationPNG_DOLDOL7	Down	R-HSA-1632852	Macroautophagy	3.309e-32	3.312e-29	ATG14;ATG4D;ATG9A;BECN1;DYNLL1;GABARAP;GABARAPL1;GABARAPL2;LAMTOR5;MAP1LC3B;MFN2;MTMR3;PINK1;RRAGA;WDR45;WIPI1;WIPI2	17	1209	0.014061207609594707	1632	Autophagy
locationPNG_DOLDOL7	Down	R-HSA-4085001	Sialic acid metabolism	4.322e-26	4.326e-23	CMAS;NPL;ST3GAL1;ST3GAL2;ST3GAL4;ST6GALNAC2;ST6GALNAC3;ST6GALNAC4;ST8SIA1;ST8SIA4	10	1209	0.008271298593879239	1632	Metabolism of proteins
locationPNG_DOLDOL7	Down	R-HSA-9020702	Interleukin-1 signaling	1.8139999999999998e-23	1.8160000000000003e-20	IL1B;IL1R1;IL1R2;IL1RAP;IL1RN;IRAK3;MAP2K6;NFKBIA;PELI1;RBX1;S100A12;SKP1;TAB2;TAB3	14	1209	0.011579818031430935	1632	Immune System
locationPNG_DOLDOL7	Down	R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	8.76e-21	8.769e-18	ALOX5;BCL2L1;BCL6;CEBPD;CXCL8;FOS;FOXO3;HGF;ICAM1;IL13RA1;IL1B;IL4R;ITGAM;ITGAX;JUNB;MAOA;MMP9;OSM;PIM1;PTGS2;SOCS3	21	1209	0.017369727047146403	1632	Immune System
locationPNG_DOLDOL7	Down	R-HSA-2262752	Cellular responses to stress	1.31e-17	1.311e-14	ACTR10;AGO4;AKT1S1;BAG1;CAT;CDC16;CDC27;CDKN2D;CEBPB;CXCL8;DCTN4;DNAJA4;DYNLL1;E2F2;ELOB;ETS2;FKBP5;FOS;FZR1;GPX1;H1F0;H2AFJ;H3F3A;H3F3B;HIGD1A;HIST1H1C;HIST1H2BC;HIST1H2BD;HSPA1A;HSPA1B;HSPA6;KDM6B;LMNB1;MAP2K3;MAP2K6;MAP2K7;MAP4K4;MAPK14;NCF2;NCF4;NUP98;PHC2;PRDX2;PRDX6;RBX1;SOD1;SOD2;ST13;TCEB2;TERF2IP;TFDP1;TFDP2;TUBA1A;TUBB2A;TUBB4B;TXN;TXNRD2;UBE2D1;UBE2D3	59	1209	0.04880066170388751	1632	Cell responses to stimuli
locationPNG_DOLDOL7	Down	R-HSA-352230	Amino acid transport across the plasma membrane	4.435e-14	4.439e-11	SLC1A5;SLC36A1;SLC38A5;SLC43A1;SLC43A2;SLC6A19;SLC6A6;SLC7A5	8	1209	0.006617038875103391	1632	Transport small molecules
locationPNG_DOLDOL7	Down	R-HSA-917937	Iron uptake and transport	1.732e-11	1.734e-8	ABCG2;ATP6V1C1;ATP6V1D;CYBRD1;FBXL5;FTH1;FTL;MCOLN1;SKP1;SLC40A1;STEAP3;TFR2;TFRC	13	1209	0.010752688172043012	1632	Transport small molecules
locationPNG_DOLDOL7	Down	R-HSA-8951664	Neddylation	6.757e-11	6.764e-8	ANKRD9;COPS2;COPS3;CUL4A;DCAF10;DCAF11;DCAF6;DCUN1D1;DDB1;ELOB;FBXL13;FBXL4;FBXL5;FBXO30;FBXO7;FBXO9;KBTBD7;KLHL2;RBX1;SKP1;SOCS3;SPSB3;TCEB2;UBE2D1;UBE2D3;UBE2F;UBE2M;WDTC1	28	1209	0.02315963606286187	1632	Metabolism of proteins
locationPNG_DOLDOL7	Down	R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	9.375e-11	9.384e-8	AGFG1;AP2A1;AP2B1;AP2M1;AP2S1;ARRB2;COPS2;COPS3;FCHO2;IGF2R;ITSN1;REPS2;SGIP1;SH3GL1;TFRC;TGFA;UBQLN1	17	1209	0.014061207609594707	1632	Vesicle-mediated transport
locationPNG_DOLDOL7	Down	R-HSA-432722	Golgi Associated Vesicle Biogenesis	1.462e-9	1.463e-6	ARF1;BLOC1S6;CPD;DNAJC6;FTH1;FTL;IGF2R;NAPA;TFRC;YIPF6	10	1209	0.008271298593879239	1632	Vesicle-mediated transport
locationPNG_DOLDOL7	Down	R-HSA-3299685	Detoxification of Reactive Oxygen Species	3.478e-9	3.481e-6	CAT;GPX1;NCF2;NCF4;PRDX2;PRDX6;SOD1;SOD2;TXN;TXNRD2	10	1209	0.008271298593879239	1632	Cell responses to stimuli
locationPNG_DOLDOL7	Down	R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	8.517e-9	8.526e-6	FCGR1A;FCGR1B;MRC2	3	1209	0.0024813895781637717	1632	Immune System
locationPNG_DOLDOL7	Down	R-HSA-174403	Glutathione synthesis and recycling	1.768e-8	1.77e-5	CHAC2;GCLC;GCLM;OPLAH	4	1209	0.0033085194375516956	1632	Metabolism
locationPNG_DOLDOL7	Down	R-HSA-913709	O-linked glycosylation of mucins	1.99e-8	1.992e-5	B3GNT5;B3GNTL1;B4GALT5;GALNT10;GALNT14;GALNT5;ST3GAL1;ST3GAL2;ST3GAL4;ST6GALNAC2;ST6GALNAC3;ST6GALNAC4	12	1209	0.009925558312655087	1632	Metabolism of proteins
locationPNG_DOLDOL7	Down	R-HSA-2559580	Oxidative Stress Induced Senescence	2.808e-8	2.811e-5	AGO4;CDKN2D;E2F2;FOS;H2AFJ;H3F3A;H3F3B;HIST1H2BC;HIST1H2BD;KDM6B;MAP2K3;MAP2K6;MAP2K7;MAP4K4;MAPK14;PHC2;TFDP1;TFDP2;TXN	19	1209	0.015715467328370553	1632	Cell responses to stimuli
locationPNG_DOLDOL7	Down	R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	8.722e-8	8.731e-5	OAZ1;OAZ2;ODC1	3	1209	0.0024813895781637717	1632	Metabolism
locationPNG_DOLDOL7	Down	R-HSA-2559583	Cellular Senescence	6.072e-7	6.078e-4	AGO4;CDC16;CDC27;CDKN2D;CEBPB;CXCL8;E2F2;ETS2;FOS;FZR1;H1F0;H2AFJ;H3F3A;H3F3B;HIST1H1C;HIST1H2BC;HIST1H2BD;KDM6B;LMNB1;MAP2K3;MAP2K6;MAP2K7;MAP4K4;MAPK14;PHC2;TERF2IP;TFDP1;TFDP2;TXN;UBE2D1	30	1209	0.02481389578163772	1632	Cell responses to stimuli