comparison	direction	pathwayId	pathwayName	pValue	pValueAdjusted	genes	numCandidateGenes	numBgGenes	geneRatio	totalGenes	topLevelPathway
locationGAM_DOLDOL1	Up	R-HSA-166786	Creation of C4 and C2 activators	5.927e-10	5.933e-7	C1QA;C1QB	2	13	0.15384615384615385	59	Immune System
locationGAM_DOLDOL1	Down	R-HSA-6798695	Neutrophil degranulation	3.131999999999999e-240	3.134999999999999e-237	ABCA13;AZU1;BPI;CAMP;CD177;CEACAM1;CEACAM6;CEACAM8;CHIT1;CLEC4D;CRISP3;CTSG;DEFA3;DEFA4;ELANE;GPR84;HP;LCN2;LTF;MMP8;MMP9;MPO;MS4A3;OLFM4;OLR1;ORM1;PGLYRP1;PTX3;RNASE3;S100P;SERPINB10;TCN1	32	44	0.7272727272727273	59	Immune System
locationGAM_DOLDOL1	Down	R-HSA-1462054	Alpha-defensins	5.518e-25	5.524e-22	DEFA3;DEFA4	2	44	0.045454545454545456	59	Immune System
locationGAM_DOLDOL1	Down	R-HSA-1592389	Activation of Matrix Metalloproteinases	2.44e-7	2.442e-4	CTSG;ELANE;MMP8;MMP9	4	44	0.09090909090909091	59	ECM organization
locationGAM_DOLDOL3	Up	R-HSA-909733	Interferon alpha/beta signaling	4.061999999999999e-102	4.0659999999999996e-99	BST2;IFI35;IFI6;IFIT1;IFIT2;IFIT3;ISG15;MX1;OAS1;OAS2;OAS3;OASL;STAT1;USP18;XAF1	15	179	0.08379888268156424	1060	Immune System
locationGAM_DOLDOL3	Up	R-HSA-877300	Interferon gamma signaling	8.268999999999999e-36	8.276999999999999e-33	GBP1;GBP3;GBP4;GBP5;HLA-DPA1;HLA-DPB1;OAS1;OAS2;OAS3;OASL;STAT1	11	179	0.061452513966480445	1060	Immune System
locationGAM_DOLDOL3	Up	R-HSA-913531	Interferon Signaling	2.5709999999999997e-33	2.574e-30	BST2;GBP1;GBP3;GBP4;GBP5;HERC5;HLA-DPA1;HLA-DPB1;IFI35;IFI6;IFIT1;IFIT2;IFIT3;ISG15;MX1;UBE2L6;USP18;XAF1	18	179	0.1005586592178771	1060	Immune System
locationGAM_DOLDOL3	Up	R-HSA-1169408	ISG15 antiviral mechanism	7.243e-21	7.25e-18	HERC5;IFIT1;ISG15;MX1;STAT1;UBE2L6;USP18	7	179	0.03910614525139665	1060	Immune System
locationGAM_DOLDOL3	Down	R-HSA-6798695	Neutrophil degranulation	0	0	ABCA13;ACTR10;ADGRE3;ADGRG3;ALAD;ANPEP;ARG1;ATP6V1D;AZU1;BPI;CAT;CD177;CD55;CD59;CEACAM1;CEACAM6;CEACAM8;CHI3L1;CHIT1;CKAP4;CLEC4D;CLEC5A;CR1;CREG1;CRISP3;CRISPLD2;CTSB;CTSG;CXCL1;CXCR1;CXCR2;CYSTM1;DEFA3;DEFA4;ELANE;FCAR;FCGR2A;FOLR3;FPR2;GCA;GPR84;GYG1;HP;HSPA1A;IGF2R;LCN2;LRG1;LTF;MAPK14;MCEMP1;MGAM;MME;MMP25;MMP8;MMP9;MPO;MS4A3;OLFM4;OLR1;ORM1;PADI2;PGLYRP1;PNP;PTX3;PYGL;QPCT;RETN;RNASE3;S100A12;S100A8;S100A9;S100P;SDCBP;SERPINB10;SLC11A1;SLC2A3;SLCO4C1;SLPI;STOM;TCN1;VNN1;YPEL5	82	777	0.10553410553410554	1060	Immune System
locationGAM_DOLDOL3	Down	R-HSA-189451	Heme biosynthesis	1.116e-46	1.117e-43	ALAD;ALAS2;CPOX;FECH;HMBS;PPOX;UROD	7	777	0.009009009009009009	1060	Metabolism
locationGAM_DOLDOL3	Down	R-HSA-1632852	Macroautophagy	4.7689999999999996e-23	4.7740000000000003e-20	ATG14;ATG4D;ATG9A;GABARAPL1;GABARAPL2;LAMTOR5;MAP1LC3B;MFN2;MTMR3;PINK1;ULK1;WIPI1;WIPI2	13	777	0.01673101673101673	1060	Autophagy
locationGAM_DOLDOL3	Down	R-HSA-1462054	Alpha-defensins	4.625e-14	4.63e-11	DEFA3;DEFA4	2	777	0.002574002574002574	1060	Immune System
locationGAM_DOLDOL3	Down	R-HSA-4085001	Sialic acid metabolism	2.157e-10	2.159e-7	CMAS;NPL;ST3GAL1;ST3GAL2;ST3GAL4;ST6GALNAC3;ST6GALNAC4	7	777	0.009009009009009009	1060	Metabolism of proteins
locationGAM_DOLDOL3	Down	R-HSA-8951664	Neddylation	2.391e-10	2.393e-7	ANKRD9;ASB7;COPS2;CUL4A;DCAF10;DCAF11;DCAF6;DCUN1D1;DDB1;FBXL13;FBXO30;FBXO7;FBXO9;KBTBD7;KLHL2;RBX1;SKP1;SOCS3;WDTC1	19	777	0.02445302445302445	1060	Metabolism of proteins
locationGAM_DOLDOL3	Down	R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	1.531e-9	1.533e-6	AGFG1;AP2A1;AP2B1;COPS2;IGF2R;ITSN1;REPS2;SGIP1;SH3GL1;STAM;TFRC;TGFA;UBQLN1	13	777	0.01673101673101673	1060	Vesicle-mediated transport
locationGAM_DOLDOL3	Down	R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	3.641e-9	3.645e-6	BCL2L1;BCL6;CEBPD;FOS;FOXO3;IL4R;LCN2;MAOA;MMP9;OSM;PIM1;PTGS2;SOCS3	13	777	0.01673101673101673	1060	Immune System
locationGAM_DOLDOL3	Down	R-HSA-8856828	Clathrin-mediated endocytosis	8.17e-9	8.178e-6	AGFG1;AP2A1;AP2B1;COPS2;DNAJC6;FNBP1L;GAPVD1;HIP1;IGF2R;ITSN1;REPS2;SGIP1;SH3GL1;STAM;TFRC;TGFA;UBQLN1	17	777	0.021879021879021878	1060	Vesicle-mediated transport
locationGAM_DOLDOL3	Down	R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	1.84e-8	1.842e-5	ASB7;CDC27;CDC34;FBXL13;FBXO30;FBXO7;FBXO9;FZR1;HECW2;KBTBD7;KLHL2;MKRN1;NEDD4L;RBX1;RNF123;RNF14;RNF19A;SIAH2;SKP1;SOCS3;TRIP12;UBAC1;UBE2B;UBE2H;UBE2O;UBR2	26	777	0.03346203346203346	1060	Immune System
locationGAM_DOLDOL3	Down	R-HSA-189445	Metabolism of porphyrins	3.509e-8	3.513e-5	ALAD;ALAS2;BLVRB;CPOX;FECH;HMBS;PPOX;UROD	8	777	0.010296010296010296	1060	Metabolism
locationGAM_DOLDOL3	Down	R-HSA-9020702	Interleukin-1 signaling	3.625e-8	3.629e-5	IL1R1;IL1R2;IL1RAP;IRAK3;RBX1;S100A12;SKP1;TAB3	8	777	0.010296010296010296	1060	Immune System
locationGAM_DOLDOL3	Down	R-HSA-1362409	Mitochondrial iron-sulfur cluster biogenesis	5.033e-8	5.038e-5	GLRX5;ISCA1;ISCU	3	777	0.003861003861003861	1060	Metabolism
locationGAM_DOLDOL3	Down	R-HSA-1592389	Activation of Matrix Metalloproteinases	8.177e-7	8.185e-4	CTSG;ELANE;FURIN;MMP25;MMP8;MMP9	6	777	0.007722007722007722	1060	ECM organization
locationGAM_DOLDOL7	Up	R-HSA-380108	Chemokine receptors bind chemokines	8.868999999999999e-65	8.877999999999998e-62	ACKR3;CCL5;CCR4;CCR9;CX3CR1;CXCL10;CXCR3;CXCR6;XCL2	9	281	0.03202846975088968	1839	Signal Transduction
locationGAM_DOLDOL7	Up	R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	2.443e-43	2.445e-40	ACKR3;CCL5;CCR4;CCR9;CX3CR1;CXCL10;CXCR3;CXCR6;CYSLTR2;GPBAR1;GPR55;GPR68;HRH4;NMUR1;OXTR;PTGDR;PTGDR2;S1PR2;S1PR5;XCL2	20	281	0.0711743772241993	1839	Signal Transduction
locationGAM_DOLDOL7	Up	R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	2.8290000000000003e-32	2.832e-29	CD160;ITGB7;KLRK1;LAIR2;SH2D1A;SH2D1B;SIGLEC1;SIGLEC8;SLAMF7	9	281	0.03202846975088968	1839	Immune System
locationGAM_DOLDOL7	Up	R-HSA-391903	Eicosanoid ligand-binding receptors	1.265e-10	1.266e-7	CYSLTR2;PTGDR;PTGDR2	3	281	0.010676156583629894	1839	Signal Transduction
locationGAM_DOLDOL7	Up	R-HSA-8877330	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	1.407e-7	1.408e-4	CTLA4;FOXP3;IL2RA;NFATC2	4	281	0.014234875444839857	1839	Gene expression
locationGAM_DOLDOL7	Down	R-HSA-6798695	Neutrophil degranulation	0	0	ABCA13;ACTR10;ADGRG3;ALAD;ALOX5;AMPD3;ANPEP;ARG1;ATP6V1D;AZU1;BPI;BST1;C5AR1;CAB39;CAMP;CAT;CD177;CD55;CD58;CD59;CDA;CEACAM1;CEACAM3;CEACAM6;CEACAM8;CHIT1;CKAP4;CLEC4D;CLEC5A;CR1;CREG1;CRISP3;CRISPLD2;CTSB;CTSG;CXCL1;CXCR1;CXCR2;CYB5R3;CYSTM1;DDX3X;DEFA3;DEFA4;DOK3;DYNLL1;ELANE;FCAR;FCER1G;FCGR2A;FCGR3B;FOLR3;FPR1;FPR2;FTH1;FTL;GCA;GOLGA7;GPR84;GYG1;HK3;HP;HSPA1A;HSPA1B;HSPA6;IGF2R;ITGAM;ITGAX;KRT1;LCN2;LGALS3;LILRB3;LRG1;LTF;MAPK14;MCEMP1;MGAM;MME;MMP25;MMP8;MMP9;MPO;MS4A3;OLFM4;OLR1;ORM1;ORMDL3;PA2G4;PADI2;PGLYRP1;PNP;PRDX6;PTX3;PYGL;QPCT;QSOX1;RAB27A;RAB6A;RETN;S100A11;S100A12;S100A8;S100A9;S100P;SDCBP;SERPINA1;SERPINB1;SERPINB10;SIGLEC5;SIGLEC9;SIRPA;SIRPB1;SLC11A1;SLC2A3;SLCO4C1;SLPI;STOM;TCN1;TLR2;TMBIM1;TNFAIP6;TUBB4B;VNN1;YPEL5	123	1308	0.09403669724770643	1839	Immune System
locationGAM_DOLDOL7	Down	R-HSA-1632852	Macroautophagy	1.2439999999999999e-74	1.2449999999999997e-71	ATG14;ATG4A;ATG4D;ATG9A;BECN1;CHMP4B;DYNLL1;GABARAP;GABARAPL1;GABARAPL2;LAMTOR5;MAP1LC3A;MAP1LC3B;MFN2;MTMR3;PINK1;RB1CC1;RRAGA;RRAGB;SQSTM1;WDR45;WIPI1;WIPI2	23	1308	0.017584097859327217	1839	Autophagy
locationGAM_DOLDOL7	Down	R-HSA-189451	Heme biosynthesis	1.0619999999999999e-51	1.063e-48	ALAD;ALAS2;CPOX;FECH;HMBS;PPOX;UROD;UROS	8	1308	0.0061162079510703364	1839	Metabolism
locationGAM_DOLDOL7	Down	R-HSA-2262752	Cellular responses to stress	3.024e-40	3.0269999999999997e-37	ACTR10;AKT1S1;BAG1;CAT;CCS;CDC16;CDC27;CDKN2C;CDKN2D;CEBPB;CITED2;CXCL8;DCTN4;DNAJA1;DNAJA2;DNAJA4;DYNLL1;E2F2;ELOB;ETS2;FKBP5;FOS;FZR1;GPX1;H1F0;H2AFJ;HIGD1A;HIST1H1C;HIST1H2BD;HIST1H3E;HSPA13;HSPA1A;HSPA1B;HSPA6;LMNB1;MAP2K3;MAP2K6;MAP2K7;MAP4K4;MAPK14;NCF4;NUP153;NUP98;PHC2;PRDX1;PRDX2;PRDX5;PRDX6;RBX1;SOD1;SOD2;ST13;TCEB2;TERF2IP;TFDP1;TFDP2;TUBB2A;TUBB4B;TXN;TXNRD2;UBE2D1;UBE2D3	62	1308	0.047400611620795105	1839	Cell responses to stimuli
locationGAM_DOLDOL7	Down	R-HSA-4085001	Sialic acid metabolism	2.729e-23	2.732e-20	CMAS;NANS;NPL;ST3GAL1;ST3GAL2;ST3GAL4;ST6GALNAC2;ST6GALNAC3;ST6GALNAC4;ST8SIA1	10	1308	0.00764525993883792	1839	Metabolism of proteins
locationGAM_DOLDOL7	Down	R-HSA-8951664	Neddylation	7.722e-23	7.73e-20	ANKRD9;ASB7;BTRC;COPS2;COPS3;CUL4A;DCAF10;DCAF11;DCAF6;DCUN1D1;DDB1;ELOB;FBXL13;FBXL4;FBXL5;FBXO30;FBXO7;FBXO9;FEM1A;FEM1C;KBTBD7;KLHL2;RBX1;SKP1;SOCS3;SPSB3;TCEB2;UBE2D1;UBE2D3;UBE2F;UBE2M;WDTC1	32	1308	0.024464831804281346	1839	Metabolism of proteins
locationGAM_DOLDOL7	Down	R-HSA-9020702	Interleukin-1 signaling	1.332e-21	1.333e-18	BTRC;IL1B;IL1R1;IL1R2;IL1RAP;IL1RN;IRAK3;MAP2K6;RBX1;S100A12;SKP1;SQSTM1;TAB2;TAB3	14	1308	0.010703363914373088	1839	Immune System
locationGAM_DOLDOL7	Down	R-HSA-3299685	Detoxification of Reactive Oxygen Species	6.955e-19	6.962e-16	CAT;CCS;GPX1;NCF4;PRDX1;PRDX2;PRDX5;PRDX6;SOD1;SOD2;TXN;TXNRD2	12	1308	0.009174311926605505	1839	Cell responses to stimuli
locationGAM_DOLDOL7	Down	R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	4.137e-16	4.141e-13	AGFG1;AP2A1;AP2B1;AP2M1;AP2S1;COPS2;COPS3;FCHO2;IGF2R;ITSN1;LDLR;PICALM;REPS2;SGIP1;SH3GL1;STAM;TFRC;TGFA;UBQLN1;VAMP7	20	1308	0.01529051987767584	1839	Vesicle-mediated transport
locationGAM_DOLDOL7	Down	R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	4.672e-15	4.677e-12	ALOX5;BCL2L1;BCL6;CEBPD;CXCL8;FOS;FOXO3;HGF;IL13RA1;IL1B;IL4R;ITGAM;ITGAX;LCN2;MAOA;MMP9;OSM;PIM1;PTGS2;SOCS3	20	1308	0.01529051987767584	1839	Immune System
locationGAM_DOLDOL7	Down	R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR)	1.595e-14	1.597e-11	ACTR10;DCTN4;DNAJA1;DNAJA2;DNAJA4;DYNLL1;FKBP5;HSPA1A;HSPA1B;TUBB2A;TUBB4B	11	1308	0.008409785932721712	1839	Cell responses to stimuli
locationGAM_DOLDOL7	Down	R-HSA-917937	Iron uptake and transport	2.221e-12	2.223e-9	ABCG2;ATP6V1C1;ATP6V1D;CYBRD1;FBXL5;FTH1;FTL;LCN2;MCOLN1;SKP1;SLC40A1;STEAP3;TFR2;TFRC	14	1308	0.010703363914373088	1839	Transport small molecules
locationGAM_DOLDOL7	Down	R-HSA-432722	Golgi Associated Vesicle Biogenesis	2.578e-12	2.581e-9	ARF1;BLOC1S6;CPD;DNAJC6;FTH1;FTL;IGF2R;NAPA;PICALM;TFRC;VAMP7;YIPF6	12	1308	0.009174311926605505	1839	Vesicle-mediated transport
locationGAM_DOLDOL7	Down	R-HSA-1462054	Alpha-defensins	1.952e-10	1.954e-7	DEFA3;DEFA4	2	1308	0.0015290519877675841	1839	Immune System
locationGAM_DOLDOL7	Down	R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	5.731e-9	5.737e-6	CARM1;ELOVL6;FDFT1;IDI1;LSS;NCOA1;NCOA2;RXRA;TBL1XR1;TM7SF2	10	1308	0.00764525993883792	1839	Metabolism
locationGAM_DOLDOL7	Down	R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	2.31e-8	2.312e-5	FCGR1A;FCGR1B;MRC2	3	1308	0.0022935779816513763	1839	Immune System
locationGAM_DOLDOL7	Down	R-HSA-9612973	Autophagy	3.916e-8	3.92e-5	ATG14;ATG4A;ATG4D;ATG9A;BECN1;DYNLL1;GABARAP;GABARAPL1;GABARAPL2;LAMTOR5;MAP1LC3A;MAP1LC3B;MFN2;MTMR3;PINK1;PLIN3;RB1CC1;RRAGA;RRAGB;SQSTM1;TSG101;UBAP1;VPS28;WDR45;WIPI1;WIPI2	26	1308	0.019877675840978593	1839	Autophagy
locationGAM_DOLDOL7	Down	R-HSA-380972	Energy dependent regulation of mTOR by LKB1-AMPK	4.423e-8	4.427e-5	CAB39;LAMTOR5;PPM1A;RRAGA;RRAGB;STK11;STRADB	7	1308	0.005351681957186544	1839	Signal Transduction
locationGAM_DOLDOL7	Down	R-HSA-202733	Cell surface interactions at the vascular wall	4.99e-8	4.995e-5	ATP1B2;BSG;CD177;CD58;CEACAM1;CEACAM3;CEACAM6;CEACAM8;FCER1G;GYPA;GYPB;GYPC;ITGAM;ITGAX;MERTK;OLR1;SIRPA;SLC16A1;SLC7A5;THBD;TREM1	21	1308	0.016055045871559634	1839	Hemostasis
locationGAM_DOLDOL7	Down	R-HSA-174403	Glutathione synthesis and recycling	8.439e-8	8.447e-5	CHAC2;GCLC;GCLM;OPLAH	4	1308	0.0030581039755351682	1839	Metabolism
locationGAM_DOLDOL7	Down	R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	2.17e-7	2.172e-4	BIRC2;BPI;BTRC;ECSIT;FOS;IRAK3;ITGAM;LY96;MAP2K3;MAP2K6;MAP2K7;MAPK14;S100A12;SKP1;TAB2;TAB3;TANK;TLR1;TLR2;TLR4;TLR6;UBE2D1;UBE2D3	23	1308	0.017584097859327217	1839	Immune System
locationGAM_DOLDOL7	Down	R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	2.34e-7	2.342e-4	OAZ1;OAZ2;ODC1	3	1308	0.0022935779816513763	1839	Metabolism
locationGAM_DOLDOL7	Down	R-HSA-8856828	Clathrin-mediated endocytosis	2.617e-7	2.62e-4	AGFG1;AP2A1;AP2B1;AP2M1;AP2S1;COPS2;COPS3;DNAJC6;FCHO2;FNBP1L;GAPVD1;HIP1;IGF2R;ITSN1;LDLR;PICALM;RAB5A;REPS2;SGIP1;SH3GL1;STAM;TFRC;TGFA;UBQLN1;VAMP7	25	1308	0.0191131498470948	1839	Vesicle-mediated transport
locationGAM_DOLDOL7	Down	R-HSA-5689896	Ovarian tumor domain proteases	3.55e-7	3.554e-4	OTUD7B;PTEN;TNIP1;TRIM25;UBE2D1;YOD1;ZRANB1	7	1308	0.005351681957186544	1839	Metabolism of proteins