Source data for Extended Data Fig. 1b,c Extended Data Fig. 1b "Time (day)" "Inducible CAR (+FUS)" "Inducible CAR (+FUS)" "Inducible CAR (+FUS)" "Inducible CAR (+FUS)" "Inducible CAR (+FUS)" "Naive (+FUS)" "Naive (+FUS)" "Naive (+FUS)" "Naive (+FUS)" "Naive (+FUS)" 9 9 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 14 14 1.13 1.44 3.25 2.09 2.49 0.12 8.92 6.58 10.98 19.95 17 17 5.72 3.43 12.85 5.14 8.93 27.42 29.32 23.90 33.03 54.40 21 21 22.51 7.10 22.99 17.87 33.95 71.63 62.59 60.88 58.63 133.27 "Table Analyzed" "EDfig.1b-Cage0806-3,4 single tumor model - effectiveness -IVIS" "Two-way RM ANOVA" "Matching: Both factors" " Assume sphericity?" No " Alpha" 0.05 "Source of Variation" "% of total variation" "P value" "P value summary" Significant? "Geisser-Greenhouse's epsilon" " Row Factor" 48.34 0.0048 ** Yes 0.3477 " Column Factor" 17.39 0.0090 ** Yes 1.000 " Interaction: Row Factor x Column Factor" 16.37 0.0042 ** Yes 0.3903 " Interaction: Row Factor x Subject" 6.546 " Interaction: Column Factor x Subject" 3.086 " Subject" 5.706 "ANOVA table" SS DF MS "F (DFn, DFd)" "P value" " Row Factor" 14115 3 4705 "F (1.043, 4.173) = 29.54" P=0.0048 " Column Factor" 5079 1 5079 "F (1, 4) = 22.55" P=0.0090 " Interaction: Row Factor x Column Factor" 4779 3 1593 "F (1.171, 4.683) = 25.56" P=0.0042 " Interaction: Row Factor x Subject" 1911 12 159.3 " Interaction: Column Factor x Subject" 901.0 4 225.2 " Subject" 1666 4 416.5 " Residual" 747.8 12 62.32 "Difference between column means" " Mean of Inducible CAR (+FUS)" 7.795 " Mean of Naive (+FUS)" 30.33 " Difference between means" -22.54 " SE of difference" 4.746 " 95% CI of difference" "-35.71 to -9.360" "Data summary" " Number of columns (Column Factor)" 2 " Number of rows (Row Factor)" 4 " Number of subjects (Subject)" 5 "Compare each cell mean with the other cell mean in that row" "Number of families" 1 "Number of comparisons per family" 3 Alpha 0.05 "Sidak's multiple comparisons test" "Mean Diff." "95.00% CI of diff." Significant? Summary "Adjusted P Value" " Inducible CAR (+FUS) - Naive (+FUS)" " 14" -7.230 "-19.39 to 4.934" No ns 0.2193 " 17" -26.40 "-48.41 to -4.393" Yes * 0.0271 " 21" -56.52 "-100.4 to -12.61" Yes * 0.0212 "Test details" "Mean 1" "Mean 2" "Mean Diff." "SE of diff." N1 N2 t DF " Inducible CAR (+FUS) - Naive (+FUS)" " 9" " 14" 2.080 9.310 -7.230 3.087 5 5 2.342 4.000 " 17" 7.214 33.61 -26.40 5.585 5 5 4.727 4.000 " 21" 20.88 77.40 -56.52 11.14 5 5 5.072 4.000 Extended Fig. 1c "Time (day)" "Cre CAR + FUS" "Cre CAR + FUS" "Cre CAR + FUS" "Cre CAR + FUS" "Cre CAR + FUS" "PL + FUS" "PL + FUS" "PL + FUS" "PL + FUS" "PL + FUS" 9 9 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 14 14 28.16 42.40 14.11 13.04 7.67 0.00 17.92 10.00 8.75 20.69 17 17 57.43 75.84 71.53 16.34 39.69 99.24 183.30 98.78 176.16 169.00 21 21 160.74 185.22 147.03 161.41 125.47 520.44 553.25 451.22 432.54 468.40 24 24 441.80 415.85 331.33 374.67 475.15 1664.64 1033.75 1130.30 1475.91 1666.00 "Table Analyzed" "EDfig.1c-Cage0806-3,4 single tumor model Caliper" "Two-way RM ANOVA" "Matching: Stacked" " Assume sphericity?" Yes " Alpha" 0.05 "Source of Variation" "% of total variation" "P value" "P value summary" Significant? " Interaction" 19.8770817478683 0.000000000001518 **** Yes " Time" 64.5596572154766 <0.000000000000001 **** Yes " Column Factor" 11.1395243122134 0.000005507752238 **** Yes " Subject" 0.794005162271620 0.547462539087925 ns No "ANOVA table" SS DF MS "F (DFn, DFd)" "P value" " Interaction" 1746389.94500061 4 436597.486250153 "F (4, 32) = 43.8094804696458" P=0.000000000001518 " Time" 5672177.51800443 4 1418044.37950111 "F (4, 32) = 142.290758662890" P<0.000000000000001 " Column Factor" 978712.745548059 1 978712.745548059 "F (1, 8) = 112.236291062327" P=0.000005507752238 " Subject" 69760.8758296950 8 8720.10947871188 "F (8, 32) = 0.875001524131354" P=0.547462539087925 " Residual" 318906.305444207 32 9965.82204513146 "Difference between column means" " Mean of Cre CAR + FUS" 127.395298400000 " Mean of PL + FUS" 407.211344480000 " Difference between means" -279.816046080000 " SE of difference" 26.4122842309587 " 95% CI of difference" "-340.722882736779 to -218.909209423221" "Data summary" " Number of columns (Column Factor)" 2 " Number of rows (Time)" 5 " Number of subjects (Subject)" 10 "Compare each cell mean with the other cell mean in that row" "Number of families" 1 "Number of comparisons per family" 5 Alpha 0.05 "Sidak's multiple comparisons test" "Mean Diff." "95.00% CI of diff." Significant? Summary "Adjusted P Value" " Cre CAR + FUS - PL + FUS" " 9" 0.00000000000000 "-168.102399051167 to 168.102399051167" No ns >0.999999999999999 " 14" 9.60300000000007 "-158.499399051167 to 177.705399051167" No ns 0.999973366136068 " 17" -93.1291999999999 "-261.231599051167 to 74.9731990511675" No ns 0.537912598001482 " 21" -329.193230400000 "-497.295629451168 to -161.090831348833" Yes **** 0.000024137709607 " 24" -986.360800000000 "-1154.46319905117 to -818.258400948833" Yes **** <0.000000000000001 "Test details" "Mean 1" "Mean 2" "Mean Diff." "SE of diff." N1 N2 t DF " Cre CAR + FUS - PL + FUS" " 9" 0.00000000000000 0.00000000000000 0.00000000000000 62.3431777561829 5 5 0.00000000000000 40.0000000000000 " 14" 21.0752000000001 11.4722000000000 9.60300000000007 62.3431777561829 5 5 0.154034496566029 40.0000000000000 " 17" 52.1663000000001 145.295500000000 -93.1291999999999 62.3431777561829 5 5 1.49381541576558 40.0000000000000 " 21" 155.974392000000 485.167622400000 -329.193230400000 62.3431777561829 5 5 5.28034088489101 40.0000000000000 " 24" 407.760600000000 1394.12140000000 -986.360800000000 62.3431777561829 5 5 15.8214713381718 40.0000000000000