Source data for Extended Data Fig. 5c
	"Time (day)"	Proxmial	Proxmial	Proxmial	Proxmial	Distal	Distal	Distal	Distal
3	3	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
7	7	2.72	2.90	3.63	7.38	5.73	8.63	3.53	6.61
11	11	0.08	15.57	15.91	43.25	0.17	36.98	31.63	40.26
14	14	36.07	43.76	38.79	172.89	73.60	102.03	153.68	157.09
18	18	57.80	35.02	100.29	376.32	201.04	164.83	484.90	379.71
21	21	567.28	233.28	988.11	1605.25	1455.68	1654.17	1771.00	2758.29
24	24	1008.37	562.79	1630.46	2070.47	1997.12	3184.89	2893.99	5000.00

"Table Analyzed"	"EDFig.5c-Cage0922-3 bilateral HspCAR no FUS IVIS"				
					
"Two-way RM ANOVA"	"Matching: Stacked"				
"    Assume sphericity?"	Yes				
"    Alpha"	0.05				
					
"Source of Variation"	"% of total variation"	"P value"	"P value summary"	Significant?	
"    Interaction"	12.0510232175830	0.000042848860691	****	Yes	
"    Time"	68.2862653821021	0.000000000000013	****	Yes	
"    Column Factor"	5.20424540831058	0.037360756514082	*	Yes	
"    Subject"	4.40230129078045	0.032399768166221	*	Yes	
					
"ANOVA table"	SS	DF	MS	"F (DFn, DFd)"	"P value"
"    Interaction"	6931509.60459643	6	1155251.60076607	"F (6, 36) = 7.19023021736093"	P=0.000042848860691
"    Time"	39276905.8537250	6	6546150.97562084	"F (6, 36) = 40.7429277926156"	P=0.000000000000013
"    Column Factor"	2993378.76801607	1	2993378.76801607	"F (1, 6) = 7.09298850472994"	P=0.037360756514082
"    Subject"	2532116.41272500	6	422019.402120833	"F (6, 36) = 2.62662839456758"	P=0.032399768166221
"    Residual"	5784106.54045000	36	160669.626123611		
					
"Difference between column means"					
"    Mean of Proxmial"	343.656785714286				
"    Mean of Distal"	806.055714285714				
"    Difference between means"	-462.398928571429				
"    SE of difference"	173.620975140191				
"    95% CI of difference"	"-887.234150249309 to -37.5637068935483"				
					
"Data summary"					
"    Number of columns (Column Factor)"	2				
"    Number of rows (Time)"	7				
"    Number of subjects (Subject)"	8				

"Compare each cell mean with the other cell mean in that row"								
								
"Number of families"	1							
"Number of comparisons per family"	7							
Alpha	0.05							
								
"Sidak's multiple comparisons test"	"Mean Diff."	"95.00% CI of diff."	Significant?	Summary	"Adjusted P Value"			
								
"  Proxmial - Distal"								
"    3"	0.00000000000000	"-887.271348335141 to 887.271348335141"	No	ns	>0.999999999999999			
"    7"	-1.96749999999997	"-889.238848335141 to 885.303848335141"	No	ns	>0.999999999999999			
"    11"	-8.55750000000012	"-895.828848335141 to 878.713848335141"	No	ns	0.999999999997829			
"    14"	-48.7224999999999	"-935.993848335141 to 838.548848335141"	No	ns	0.999999590349330			
"    18"	-165.262500000000	"-1052.53384833514 to 722.008848335141"	No	ns	0.998423205605531			
"    21"	-1061.30500000000	"-1948.57634833514 to -174.033651664859"	Yes	*	0.011197940556199			
"    24"	-1950.97750000000	"-2838.24884833514 to -1063.70615166486"	Yes	****	0.000001430605213			
								
								
"Test details"	"Mean 1"	"Mean 2"	"Mean Diff."	"SE of diff."	N1	N2	t	DF
								
"  Proxmial - Distal"								
"    3"	0.999999999999659	0.999999999999659	0.00000000000000	314.646872230544	4	4	0.00000000000000	42.0000000000000
"    7"	4.15750000000003	6.12500000000000	-1.96749999999997	314.646872230544	4	4	0.00625304165921717	42.0000000000000
"    11"	18.7025000000001	27.2600000000002	-8.55750000000012	314.646872230544	4	4	0.0271971557808144	42.0000000000000
"    14"	72.8774999999999	121.600000000000	-48.7224999999999	314.646872230544	4	4	0.154848194277617	42.0000000000000
"    18"	142.357500000000	307.620000000000	-165.262500000000	314.646872230544	4	4	0.525231663129042	42.0000000000000
"    21"	848.480000000000	1909.78500000000	-1061.30500000000	314.646872230544	4	4	3.37300349587577	42.0000000000000
"    24"	1318.02250000000	3269.00000000000	-1950.97750000000	314.646872230544	4	4	6.20053041102696	42.0000000000000